tbuckley/cabot-search huggingface dataset:
Practical Guide to Epilepsy
Authors: Jerome Engel
Journal: Annals of Internal Medicine (2003)

Medical Writings: Book Notes2 September 2003Practical Guide to EpilepsyJerome Engel Jr., MD, PhDJerome Engel Jr., MD, PhDDavid Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-139-5_Part_1-200309020-00027 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Manford M. 335 pages. Burlington, MA: Butterworth-Heinemann; 2003. $44.95. ISBN 0750646217. Order phone 800-545-2522.Field of medicine: Neurology and epileptology.Format: Softcover book.Audience: Primary care physicians in managed care practices who will see an increasing number of patients who in the past would have been referred to a specialist.Purpose: To provide a practical approach to the diagnosis and treatment of epileptic seizures and epilepsy.Content: The five sectionsclinical science, diagnosis, treatment, special situations, and psychosocial issuesare problem oriented, with frequent case examples, tables, and diagrammatic algorithms.Highlights: This book is comprehensive, covering almost all aspects of epileptology that ... Author, Article, and Disclosure InformationAffiliations: David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 2 September 2003Volume 139, Issue 5_Part_1Page: 388KeywordsAlgorithmsConsciousnessDrugsEpilepsyEpileptic seizuresNeurologyPrimary care physiciansSexual identitySoftware toolsStatus epilepticus ePublished: 2 September 2003 Issue Published: 2 September 2003 Copyright & PermissionsCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
A NEW EYE SPECULUM.
Authors: O. B. MONOSMITH
Journal: JAMA (1907)

This improved eye speculum is made entirely of brass and is, therefore, non-magnetic. It is composed of only two parts, which are easily detached for cleansing. It has neither spring, setscrew, hinge or ratchet. It is very light, weighing less than three drams. It is introduced easily without changing hands, locking itself automatically. It can be removed very quickly without the resistance of a spring to overcome, a setscrew to loosen or the fear that it may slip from the hand. It takes but a moment to increase or to diminish the pressure on the lids. It has the advantage of the original Mellinger's speculum in that the blades open parallel. The blades are solid and conform to the curve of the lid margin. The pressure on the sensitive lid, therefore, is equally distributed, reducing the distress and reflex spasm to a minimum. The under surfaces of the blades are
Innovation in general practice
Authors: M Bedford
Journal: BMJ (1988)

is a familiar example.My limited personal ex- perience as a kinesiology subject suggests that after a few tests the arms tire and responding becomes confounded with the cumulative effects of being repeatedly tested.Professor Garrow's experi- mental design does not allow the effects of repeated testing to be differentiated from those of know- ledge of the identity of the test substances.Conclusions about the reliability of the kinesiology response are premature.
Arteriohepatic Dysplasia. Ii. Hepatobiliary Morphology
Authors: Ellen I. Kahn, Fredric Daum, James Markowitz, Harvey W. Aiges, Keith M. Schneider, Henry B. So, Peter Altman, Roma S. Chandra, Mervin Silverberg
Journal: Hepatology (1983)

Five children were noted to have arteriohepatic dysplasia (Alagille's syndrome) between 3 and 7 months of age. Prior to diagnosis, four underwent Kasai procedures after intraoperative cholangiograms failed to demonstrate patency of the extrahepatic bile ducts. In three patients, a focal proximal hypoplasia of the common hepatic duct was demonstrated with fibrosis and increased vascularity. Hypoplasia of the gallbladder occurred in two patients. Changes were observed in the porta hepatis. Eighty of 208 micrometers bile ducts were associated with peripherally located gland-like structures. These changes are indistinguishable from those in fibrous remnants of extrahepatic biliary atresia. Hepatic features of sequential liver biopsies obtained in the five patients were divided into early and late changes. From birth to 3 months of age, the pathology consisted of cholestasis and bile duct destruction. After 3 months of age, there was persistent cholestasis, paucity of interlobular bile ducts, and portal fibrosis. Ductular proliferation was not an intrinsic change. When present, it was related to a recent episode of cholangitis.
Liver disease and platelet function in alcoholics.
Authors: M Hillbom, A Muuronen, J Neiman
Journal: BMJ (1987)

Liver disease and platelet function in alcoholicsMikhailidis et al reported that chronic alcohol ingestion exerts an inhibitory effect on platelet function even in the absence ofalcohol in the blood and that this phenomenon is reversible with abstinence.Platelet aggregation and associated thromboxane formation were inhibited on admission but returned to normal or became hyperresponsive during two to three weeks of abstinence.Their data also suggested a relation between the bleeding time and estimated alcohol intake during the week preceding detoxification.'As alcoholic cirrhosis of the liver may cause bleeding and coagulation abnormalities we decided to see whether the inhibited platelet function of alcoholics on admission for detoxification might be related to liver disease in these patients.
Review: Several instruments are accurate for evaluating patient capacity for medical treatment decision-making
Authors: Joel Howell
Journal: Annals of Internal Medicine (2011)

ACP Journal Club15 November 2011Review: Several instruments are accurate for evaluating patient capacity for medical treatment decision-makingJoel Howell, MD, PhDJoel Howell, MD, PhDUniversity of Michigan, Ann Arbor, Michigan, USA (J.H.)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-155-10-201111150-02012 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationSessums LL, Zembrzuska H, Jackson JL. Does this patient have medical decision-making capacity? JAMA. 2011;306:420-7. https://pubmed.ncbi.nlm.nih.gov/21791691Clinical Impact RatingsGIM/FP/GP: Hospitalists: Geriatrics: Reference1 Jourdan JB, Glickman L. Reasons for requests for evaluation of competency in a municipal general hospital. Psychosomatics. 1991;32:413-6. [PMID: 1961854] Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Michigan, Ann Arbor, Michigan, USA (J.H.)This article was published at Annals.org on 1 November 2011. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 November 2011Volume 155, Issue 10Page: JC5-12KeywordsDisclosureElderlyForensicsInpatientsNursing homesPatientsProspective studiesQuestionnairesSpecificity ePublished: 15 November 2011 Issue Published: 15 November 2011 CopyrightCopyright © 2011 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Acquired tufted angioma showing spontaneous regression
Authors: T. MIYAMOTO, M. MIHARA, E. MISHIMA, Y. HAGARI, S. SHIMAO
Journal: British Journal of Dermatology (1992)

Journal Article Acquired tufted angioma showing spontaneous regression Get access T. MIYAMOTO, T. MIYAMOTO Division of Dermatology, Tsuyama Central Hospital, Tsuyama, Japan Dr T. Miyamoto, Division of Dermatology, Tsuyama Central Hospital, Nikaimachi 67, Tsuyama 708, Japan. Search for other works by this author on: Oxford Academic Google Scholar M. MIHARA, M. MIHARA Department of Dermatology, Tottori University School of Medicine, Yonago, Japan Search for other works by this author on: Oxford Academic Google Scholar E. MISHIMA, E. MISHIMA Department of Dermatology, Tottori University School of Medicine, Yonago, Japan Search for other works by this author on: Oxford Academic Google Scholar Y. HAGARI, Y. HAGARI Department of Dermatology, Tottori University School of Medicine, Yonago, Japan Search for other works by this author on: Oxford Academic Google Scholar S. SHIMAO S. SHIMAO Department of Dermatology, Tottori University School of Medicine, Yonago, Japan Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 127, Issue 6, 1 December 1992, Pages 645–648, https://doi.org/10.1111/j.1365-2133.1992.tb14881.x Published: 01 December 1992
THE TOTAL BLOOD VOLUME IN PERNICIOUS ANEMIA
Authors: EDWARD LINDEMAN
Journal: JAMA (1918)

In a preliminary report,<sup>1</sup>I described a new method for the estimation of the total volume of blood in anemia. In no disease is it of greater importance to know the volume of blood in the body than in pernicious anemia. We find patients in this disease bearing their illness variably, though the degree of anemia in all may be the same. In many the same group of symptoms are present, varying only in intensity. I believe that individual peculiarities may account for differences in the intensity of symptoms, and that also some differences may possibly be accounted for by varying degrees of toxicity; nevertheless, the main factor, in my opinion, is the hitherto unrecognized importance of blood volume. Rancke has demonstrated that the blood is thus distributed in the various organs: In the rabbit, onefourth to the heart, lungs and great vessels; one-fourth to the resting muscles, and
688 RISK FACTORS FOR HEPATOCELLULAR CARCINOMA OR LIVER FAILURE IN CAUCASIANS PATIENTS WITH NON-VIRAL CIRRHOSIS: THE IMPORTANCE OF PAST OVERWEIGHT
Authors: I. Archambeaud, H. Auble, G. Fallot, C. Scoul, S. Bardot, B. Roche, R. Faroux, D. Samuel, P. Nahon, C. Feray
Journal: Journal of Hepatology (2012)
MENTAL SYMPTOMS IN CASES OF TUMOR OF TEMPORAL LOBE
Authors: PAUL GAL
Journal: American Journal of Psychiatry (1958)

In the series of 61 temporal lobe tumors there were mental symptoms in 50 cases. As initial symptoms there were mental manifestations in 37 cases before any neurological signs appeared. The symptoms were are follows: 1. fits (hallucinations, visual illusions, dreamy state, automatism, psychomotor equivalent, temporal epilepsy), 2. changes in personality, 3. disorders of mood, 4. schizoform psychosis, 5. parietal mental symptoms, 6. psycho-organic syndrome. We do not assume a definite mental syndrome of tumor of temporal lobe. We would only emphasize, that the psychic syndromes are never manifestations only of damage of a circumscribed part of the brain, but always as a damage of the function of the brain as a whole. From the clinical symptoms and their connections with the local lesions, one can only conclude that certain neuron groups play greater part in some or in specific brain activities. On the basis of literary data, of our own material and observations with electric stimulations of the cortex by Penfield and co-workers, we assume, that some type of hallucinations, déjà vu experiences, dreamy states, automatism, psychomotor equivalence, temporal epilepsy can be—with great probability—significant of temporal lobe lesions. Paying more attention to these symptoms and making greater use of the results of other examinations we will be enabled to make an earlier and more accurate diagnosis to establish the temporal lobe tumor.
French protest at health budget cuts
Authors: A. Dorozynski
Journal: BMJ (1995)

<h3>Objectives</h3> Cerebral amyloid angiopathy (CAA) is associated with lobar intracerebral haemorrhage (ICH). While only the ε4 allele of the apolipoprotein E (APOE) gene is associated with the presence of CAA, both APOE-ε4 and ε2 are associated with lobar ICH. The generally accepted explanation is that APOE-ε4 promotes vascular amyloid deposition, while APOE-ε2 promotes progression to severe CAA with associated vasculopathic changes that cause vessel rupture and ICH. We assessed the evidence for these allele-specific effects. <h3>Methods</h3> We systematically identified published studies with data on APOE genotype and histopathological assessment of postmortem brains for CAA severity. We obtained unpublished data from these for meta-analyses of the effects of ε4-containing (ε4+) and ε2-containing (ε2+) genotypes on progression to severe CAA. <h3>Results</h3> Of six eligible studies (543 eligible participants), data were available from 5 (497 participants, 353 with CAA). Meta-analyses showed a possible association of ε4+ genotypes with severe CAA (ε4+ vs ε4−: severe vs mild/moderate CAA, OR 2.5, 95% CI 1.4 to 4.5, p=0.002; severe vs moderate CAA, OR 1.7, 95% CI 0.9 to 3.1, p=0.11). For ε2+ versus ε2− genotypes, there was no significant association, but the very small number of participants with ε2+ genotypes (22) precluded reliable estimates. <h3>Conclusions</h3> We found a possible association of severe CAA with APOE-ε4 but not APOE-ε2. However, our findings do not exclude a biologically meaningful association between APOE-ε2 and severe CAA. Further work is needed to elucidate fully the allele-specific associations of APOE with CAA and their mechanisms.
Book Review Multidisciplinary Management of Female Pelvic Floor Disorders Edited by Christopher R. Chapple, Philippe E. Zimmern, Linda Brubaker, Anthony R.B. Smith, and Kari Bø. 369 pp., illustrated. Philadelphia, Churchill Livingstone, 2006. $179. 978-0-4430-7272-7
Authors: Rebecca G. Rogers
Journal: New England Journal of Medicine (2007)
Dutch Supreme Court backs damages for child for having been born
Authors: Tony Sheldon
Journal: BMJ (2005)

The Dutch Supreme Court has agreed to the award of damages to a severely disabled child for the fact that she was born—a so called wrongful life. This is the first such case in the Netherlands, and the decision sets it apart from international opinion.

Kelly Molenaar, now 11, was born with several mental and physical disabilities as a result of a chromosomal abnormality inherited through her father. Her mother had been aware of the genetic risks and had asked a midwife at the Leiden University Medical Centre whether prenatal diagnostic tests were necessary. She was told they were not, and neither …
The Periodic Health Examination Revisited
Authors: THOMAS L. DELBANCO
Journal: Annals of Internal Medicine (1975)

The periodic health examination of the apparently well has become a cornerstone of medical practice. It has been advocated for more than 100 years as the best method for insuring the continued health of a given patient (1). The periodic health examination differs from screening and diagnostic evaluation. The differences include patient motivation, the purpose of tests, and the nature of the provider-patient relation. Screening is directed at an apparently well population; the objective is to identify unrecognized disease or risk of disease with tests that are not meant to be diagnostic. Screening carries no necessity for a patient-physician contract.
Numerous transposed sequences of mitochondrial cytochrome oxidase I-II in aphids of the genus Sitobion (Hemiptera: Aphididae)
Authors: P. Sunnucks, D. F. Hales
Journal: Molecular Biology and Evolution (1996)

Polymerase chain reaction (PCR) products corresponding to 803 bp of the cytochrome oxidase subunits I and II region of mitochondrial DNA (mtDNA COI-II) were deduced to consist of multiple haplotypes in three Sitobion species. We investigated the molecular basis of these observations. PCR products were cloned, and six clones from one individual per species were sequenced. In each individual, one sequence was found commonly, but also two or three divergent sequences were seen. The divergent sequences were shown to be nonmitochondrial by sequencing from purified mtDNA and Southern blotting experiments. All seven nonmitochondrial clones sequenced to completion were unique. Nonmitochondrial sequences have a high proportion of unique sites, and very few characters are shared between nonmitochondrial clones to the exclusion of mtDNA. From these data, we infer that fragments of mtDNA have been transposed separately (probably into aphid chromosomes), at a frequency only known to be equalled in humans. The transposition phenomenon appears to occur infrequently or not at all in closely related genera and other aphids investigated. Patterns of nucleotide substitution in mtDNA inferred over a parsimony tree are very different from those in transposed sequences. Compared with mtDNA, nonmitochondrial sequences have less codon position bias, more even exchanges between A, G, C and T, and a higher proportion of nonsynonymous replacements. Although these data are consistent with the transposed sequences being under less constraint than mtDNA, changes in the nonmitochondrial sequences are not random: there remains significant position bias, and probable excesses of synonymous replacements and of conservative inferred amino acid replacements. We conclude that a proportion of the inferred change in the nonmitochondrial sequences occurred before transposition. We believe that Sitobion aphids (and other species exhibiting mtDNA transposition) may be important for studying the molecular evolution of mtDNA and pseudogenes. However, our data highlight the need to establish the true evolutionary relationships between sequences in comparative investigations.
Hypoventilatory respiratory failure in generalised scleroderma
Authors: G. D Iliffe, N. M Pettigrew
Journal: BMJ (1983)

A patient with generalised cutaneous and gastrointestinal scleroderma subsequently died from respiratory failure secondary to hyperventilation. At necropsy changes consistent with scleroderma of the diaphragm were found; these were thought to have contributed appreciably to the terminal respiratory failure. This case indicates that diaphragmatic changes should be added to the list of respiratory complications of scleroderma.
TISSUE INTERRELATIONSHIPS IN CUTANEOUS GRANULOMA
Authors: F. Schellander, R. Marks
Journal: British Journal of Dermatology (1973)

Journal Article TISSUE INTERRELATIONSHIPS IN CUTANEOUS GRANULOMA Get access F. Schellander, F. Schellander Department of Experimantal Pathology, Institute of Dermatology, St John's Hospital, Leicester Square, London WC2H 7BJ Search for other works by this author on: Oxford Academic Google Scholar R. Marks R. Marks Department of Experimantal Pathology, Institute of Dermatology, St John's Hospital, Leicester Square, London WC2H 7BJ Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 89, Issue 5, 1 November 1973, Pages 537–542, https://doi.org/10.1111/j.1365-2133.1973.tb03019.x Published: 01 November 1973
Biospecific haemosorbents based on proteinase inhibitorII. Efficiency of biospecific antiproteinase haemosorbent ‘Ovosorb’ in complex treatment of experimental generalized purulent peritonitis and acute destructive pancreatitis in dogs
Authors: N PLATE, V KIRKOVSKY, O ANTIPEROVICH, V NICOLAICHIK, T VALUEVA, S SINILO, V MOIN, G LOBACHEVA
Journal: Biomaterials (1994)
Interstitial del(14)(q) involving IGH: a novel recurrent aberration in B-NHL
Authors: H Pospisilova, M Baens, L Michaux, M Stul, P Van Hummelen, P Van Loo, J Vermeesch, M Jarosova, Z Zemanova, K Michalova, I Van den Berghe, H D Alexander, A Hagemeijer, P Vandenberghe, J Cools, C De Wolf-Peeters, P Marynen, I Wlodarska
Journal: Leukemia (2007)
Anti-Monocyte Chemoattractant Protein-1 Gene Therapy Limits Progression and Destabilization of Established Atherosclerosis in Apolipoprotein E–Knockout Mice
Authors: Shujiro Inoue, Kensuke Egashira, Weihua Ni, Shiro Kitamoto, Makoto Usui, Kisho Otani, Minako Ishibashi, Ken-ichi Hiasa, Ken-ichi Nishida, Akira Takeshita
Journal: Circulation (2002)

Background— Monocyte infiltration into the arterial wall and its activation is the central event in atherogenesis. Thus, monocyte chemoattractant protein-1 (MCP-1) might be a novel therapeutic target against atherogenesis. We and others recently reported that blockade or abrogation of the MCP-1 pathway attenuates the initiation of atheroma formation in hypercholesterolemic mice. It remains unclear, however, whether blockade of MCP-1 can limit progression or destabilization of established lesions. Methods and Results— We report here that blockade of MCP-1 by transfecting an N -terminal deletion mutant of the MCP-1 gene limited progression of preexisting atherosclerotic lesions in the aortic root in hypercholesterolemic mice. In addition, blockade of MCP-1 changed the lesion composition into a more stable phenotype, ie, containing fewer macrophages and lymphocytes, less lipid, and more smooth muscle cells and collagen. This strategy decreased expression of CD40 and the CD40 ligand in the atherosclerotic plaque and normalized the increased chemokine (RANTES and MCP-1) and cytokine (tumor necrosis factor α, interleukin-6, interleukin-1β, and transforming growth factor β 1 ) gene expression. These data suggest that MCP-1 is a central mediator in the progression and destabilization of established atheroma. Conclusions— The results of the present study suggest that the inflammatory responses mediated by MCP-1 are important in atherosclerosis and its complications.
PTH-010 The Safety And Efficacy Of Transpancreatic Sphincterotomy For Difficult Cbd Cannulation During Ercp: A District General Hospital’s Experience: Abstract PTH-010 Table 1
Authors: J Mcgonigle, V Mitra, D Dwarakanath, D Majumar, B Chaudhury, J Hancock
Journal: Gut (2014)

<h3>Introduction</h3> Transpancreatic sphincterotomy (TPS) for difficult common bile duct cannulation during ERCP was first described by Goff in 1995. Since then its safety and efficacy has been debated with some concerns regarding high post ERCP pancreatitis rates (PEP). In published data from recent years PEP can range from 6–20% when TPS is carried out. The majority of TPS is carried out in tertiary referral centres but it is a technique that we have increasingly adopted in our district general hospital when common bile duct cannulation is proving difficult. We wished to review the safety and efficacy of this technique and compare our results to the literature <h3>Methods</h3> We reviewed all procedure notes from ERCPs that been had been carried out from October 2011 - October 2013. The reports were reviewed and any cases where transpancretic sphincterotomy was performed were identified. We subsequently reviewed our radiology reporting system, the patients discharge letter and blood results as well as any subsequent hospital admissions to determine any complications. We noted any post ERCP pancreatitis, upper GI bleeding, perforation or death. Complications were classified using the system proposed by Cotton <i>et al</i>. We compared our complication rates to our departments overall complication rates <h3>Results</h3> Out of 811 ERCPs carried out in the date range 31 patients were identified who had a transpancreatic sphincterotomy performed. 21 cases (68%) were performed by a consultant whilst 10 cases (32%) were performed by a senior registrar. Successful CBD cannulation was achieved in 25 patients (80%) and in the 6 that failed it was subsequently successful at a later date in 4 patients. Our complication rates are shown in the below table <h3>Conclusion</h3> Our results show that transpancreatict sphincterotomy can be carried out at a district general hospital with similar levels of success and complications as reported in the literature from tertiary centres worldwide. In such a small data set a single patient death can bias the results and on reviewing the notes the patient died from a perforation due to a common bile duct stent migrating into the duodenal wall. We concluded this was not related to the technique of PDS and should not deter us from continuing this practice. As expected our complication rates are higher that our units normal complication rates which reflects the challenging nature of the cases when PDS is attempted. <h3>Disclosure of Interest</h3> None Declared.