Chronic Lymphocytic Leukemia: Recommendations
Authors: B. D. Cheson, J. M. Bennett, K. R. Rai, M. R. Grever, N. E. Kay, M. M. Oken, C. A. Schiffer, M. J. Keating, D. H. Boldt, S. J. Kempin
Journal: Annals of Internal Medicine (1989)

Letters and Corrections15 April 1989Chronic Lymphocytic Leukemia: RecommendationsBruce D. Cheson, MD, FACP, John M. Bennett, MD, Kanti R. Rai, MD, Michael R. Grever, MD, Neil E. Kay, MD, Martin M. Oken, MD, Charles A. Schiffer, MD, Michael J. Keating, MD, David H. Boldt, MD, San ford J. Kempin, MD, Kenneth A. Foon, MDBruce D. Cheson, MD, FACPSearch for more papers by this author, John M. Bennett, MDSearch for more papers by this author, Kanti R. Rai, MDSearch for more papers by this author, Michael R. Grever, MDSearch for more papers by this author, Neil E. Kay, MDSearch for more papers by this author, Martin M. Oken, MDSearch for more papers by this author, Charles A. Schiffer, MDSearch for more papers by this author, Michael J. Keating, MDSearch for more papers by this author, David H. Boldt, MDSearch for more papers by this author, San ford J. Kempin, MDSearch for more papers by this author, Kenneth A. Foon, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-110-8-664 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:The International Working Group on Chronic Lymphocytic Leukemia (1) recently presented its recommendations for the design of clinical trials. There has clearly been a need for standardized criteria for eligibility, response, and toxicity to make published data more interpretable, to allow for the accurate identification of pilot regimens of sufficient interest for testing in large-scale comparative trials, and to minimize the arbitrary nature of dose modifications. Interpretation of results of clinical trials has been complicated by the use of two different staging systems, the Rai (2) and the Binet (3). In 1981, the International Working Group proposed...References1. Chronic lymphocytic leukemia: recommendations for diagnosis, staging, and response criteria. International Workshop on Chronic Lymphocytic Leukemia. Ann Intern Med. 1989;110:236-8. LinkGoogle Scholar2. Rai K. A critical analysis of staging in CLL. In: Gale RP, Rai KR, eds. Chronic Lymphocytic Leukemia: Recent Progress and Future Directions: Proceedings of a Hyland Laboratory-UCLA Symposium Held in Napa, California, December 2-5, 1986. New York: Alan R. Liss, Inc.; 1987:253-64. (UCLA Symposia on Molecular and Cellular Biology; new series no 59). Google Scholar3. BinetAuquierDighiero JAG. A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis. Cancer. 1981;48:198-206. CrossrefMedlineGoogle Scholar4. BinetCatovskyChandra JDP. Chronic lymphocytic leukemia: proposals for a revised prognostic scoring system. Br J Haematol. 1981;48:365-7. CrossrefMedlineGoogle Scholar5. ChesonBennettRai BJK. Guidelines for clinical protocols for chronic lymphocytic leukemia: report of the NCI-sponsored Working Group. Am J Hematol. 1988;29:152-63. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byChronic lymphocytic leukemia with low lymphocyte count 15 April 1989Volume 110, Issue 8Page: 664-665KeywordsChronic lymphocytic leukemiaClinical trialsToxicity Issue Published: 15 April 1989 PDF downloadLoading ...