Ectopic Hormones from Tumors
Authors: STEWART A. METZ
Journal: Annals of Internal Medicine (1975)

Comments and Correction1 July 1975Ectopic Hormones from TumorsSTEWART A. METZ, M.D.STEWART A. METZ, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-83-1-117 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The recent paper by Samaan and colleagues (Ann Intern Med 82:205-207, 1975) and the concomitant editorial by Rosen and Weintraub (pp. 274-276) were interesting, but they foster a recent tendency to muddle the distinction between the phenomenon of multiple endocrine neoplasia with that of ectopic hormone production and so to infer a common pathophysiology.In recent years, the concept that there is no discernible pattern to ectopic production of hormones by tumors has been largely, and I believe correctly, supplanted by the bias that there is a discernible and often predictable pattern to this phenomenon (1, 2,...References1. WILLIAMS E: Tumours, hormones, and cellular differentiation. Lancet 2:1108-1110, 1969 CrossrefMedlineGoogle Scholar2. LEVINEMETZ RS: A classification of ectopic hormone-producing tumors. Ann NY Acad Sci 230:533-546, 1974 CrossrefMedlineGoogle Scholar3. WEICHERT R: The neural ectodermal origin of the peptide-secreting endocrine glands. A unifying concept for the etiology of multiple endocrine adenomatosis, and the inappropriate secretion of hormones by nonendocrine tumors. Am J Med 49:232-241, 1970 CrossrefMedlineGoogle Scholar4. WERMER P: Multiple endocrine adenomatosis; multiple hormone-producing tumors, a familial syndrome. Clinics in Gastroenterology. 3:671-684, 1974 CrossrefGoogle Scholar5. PEARSEPOLAK AJ: Neural crest origin of the endocrine polypeptide (APUD) cells of the gastrointestinal tract and pancreas. Gut 12:783-788, 1971 CrossrefMedlineGoogle Scholar6. PEARSE A: The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept. J Histochem Cytochem 17:303-313, 1969 CrossrefMedlineGoogle Scholar7. ANDREW A: A study of the developmental relationship between enterochromaffin cells and the neural crest. J Embryo Exp Morphol 2:307-327, 1963 Google Scholar8. KREISERBEAVENDOPPMAN HMJ: Sipple's syndrome: medullary thyroid carcinoma, pheochromocytoma, and parathyroid disease. Studies in a large family. Ann Intern Med 78:561-579, 1973 LinkGoogle Scholar1. LEVINEMETZ RS: A classification of ectopic hormone-producing tumors. Ann NY Acad Sci 230:533-546, 1974 CrossrefMedlineGoogle Scholar2. PEARSE A: The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept. J Histochem Cytochem 17:303-313, 1969 CrossrefMedlineGoogle Scholar3. OMENN G: Ectopic polypeptide hormone production by tumors. Ann Intern Med 72:136-138, 1970 LinkGoogle Scholar4. GEWIRTZYALOW GR: Ectopic ACTH production in carcinoma of the lung. J Clin Invest 53:1022-1032, 1974 CrossrefMedlineGoogle Scholar5. BRAUNSTEINVAITUKAITISCARBONE GJP: Ectopic production of human chorionic gonadotrophin by neoplasms. Ann Intern Med 78:39-45, 1973 LinkGoogle Scholar6. ROSENWEINTRAUB SB: Ectopic production of the isolated alpha subunit of the glycoprotein hormones: a quantitative marker in certain cases of cancer. N Engl J Med 290:1441-1447, 1974 CrossrefMedlineGoogle Scholar7. WEINTRAUBROSEN BS: Ectopic production of human chorionic somatomammotropin by nontrophoblastic cancers. J Clin Endocrinol Metab 32:94-101, 1971 CrossrefMedlineGoogle Scholar8. MUGGIAROSENWEINTRAUB FSB: Ectopic placental proteins in nontrophoblastic tumors: serial measurements following chemotherapy. Cancer, in press Google Scholar9. FEINSTEINGELFMANYESNER ANR: Observer variability in the histopathologic diagnosis of lung cancer. Am Rev Resp Dis 101:671-684, 1970 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine University of Washington Seattle, Washington 98195 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByHormone production by cultures of small-cell carcinoma of the lung 1 July 1975Volume 83, Issue 1Page: 117-118KeywordsHormonesMultiple endocrine neoplasia Issue Published: 1 July 1975 PDF DownloadLoading ...