Healthy Ranges for Alanine Aminotransferase Levels
Authors: Francesco G. De Rosa, Stefano Bonora, Giovanni Di Perri
Journal: Annals of Internal Medicine (2003)

Letters21 January 2003Healthy Ranges for Alanine Aminotransferase LevelsFrancesco G. De Rosa, MD, Stefano Bonora, MD, and Giovanni Di Perri, MD, PhDFrancesco G. De Rosa, MDUniversity of Turin; 10149 Turin, ItalySearch for more papers by this author, Stefano Bonora, MDUniversity of Turin; 10149 Turin, ItalySearch for more papers by this author, and Giovanni Di Perri, MD, PhDUniversity of Turin; 10149 Turin, ItalySearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-138-2-200301210-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Prati and colleagues' proposal to update definitions of healthy ranges for serum ALT levels is interesting, as is the flexibility with which they recommend the new definitions should be applied (1). These new levels will be very useful for rare cases in which a differential diagnosis between systemic lupus erythematosus (SLE) and HCV-associated type II mixed cryoglobulinemia is required. Studies of HCV infection in patients with SLE and cryoglobulinemia clearly show the similarities of clinical findings and type of cryoglobulins (2, 3). Type II mixed cryoglobulinemia associated with HCV is a vasculitic syndrome that was first described ...References1. Prati D, Taioli E, Zanella A, Della Torre E, Butelli S, Del Vecchio E, et al . Updated definitions of healthy ranges for serum alanine aminotransferase levels. Ann Intern Med. 2002;137:1-10. [PMID: 12093239] LinkGoogle Scholar2. Garca-Carrasco M, Ramos-Casals M, Cervera R, Trejo O, Yage J, Sis A, et al . Cryoglobulinemia in systemic lupus erythematosus: prevalence and clinical characteristics in a series of 122 patients. Semin Arthritis Rheum. 2001;30:366-73. [PMID: 11303309] CrossrefMedlineGoogle Scholar3. Ramos-Casals M, Font J, Garca-Carrasco M, Cervera R, Jimnez S, Trejo O, et al . Hepatitis C virus infection mimicking systemic lupus erythematosus: study of hepatitis C virus infection in a series of 134 Spanish patients with systemic lupus erythematosus. Arthritis Rheum. 2000;43:2801-6. [PMID: 11145039] CrossrefMedlineGoogle Scholar4. Meltzer M, Franklin EC. Cryoglobulinemiaa study of twenty-nine patients. I. IgG and IgM cryoglobulins and factors affecting cryoprecipitability. Am J Med. 1966;40:828-36. [PMID: 4956870] CrossrefMedlineGoogle Scholar5. Agnello V. The etiology and pathophysiology of mixed cryoglobulinemia secondary to hepatitis C virus infection. Springer Semin Immunopathol. 1997;19:111-29. [PMID: 9266635] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Francesco G. De Rosa, MD; Stefano Bonora, MD; Giovanni Di Perri, MD, PhDAffiliations: University of Turin; 10149 Turin, Italy PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoUpdated Definitions of Healthy Ranges for Serum Alanine Aminotransferase Levels Daniele Prati , Emanuela Taioli , Alberto Zanella , Emanuela Della Torre , Sonia Butelli , Emanuela Del Vecchio , Luciana Vianello , Francesco Zanuso , Fulvio Mozzi , Silvano Milani , Dario Conte , Massimo Colombo , and Girolamo Sirchia Healthy Ranges for Alanine Aminotransferase Levels Daniele Prati , Agostino Colli , and Dario Conte Healthy Ranges for Alanine Aminotransferase Levels John R. Senior Metrics Cited byEvaluation of dithiothreitol-oxidizing capacity (DOC) as a serum biomarker for chronic hepatitis B in patients exhibiting normal alanine aminotransferase levels: a pilot study towards better monitoring of diseaseUnintended Hepatic Adverse Events Associated with Cancer Chemotherapy 21 January 2003Volume 138, Issue 2 Page: 156-157 Keywords Alanine aminotransferase Antibodies Cirrhosis Infectious diseases Liver Liver diseases Lupus erythematosus RNA Vasculitis ePublished: 21 January 2003 Issue Published: 21 January 2003 Copyright & PermissionsCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...