tbuckley/cabot-search huggingface dataset:
Landmark article Oct 28, 1933. Successful removal of an entire lung for carcinoma of the bronchus. By Evarts A. Graham and J. J. Singer
Authors: E. A. Graham
Journal: JAMA (1984)

The left lung and many of the tracheobronchial mediastinal glands were removed in a one stage operation because of a carcinoma that originated in the bronchus of the upper lobe but which was so close to the bronchus of the lower lobe that, in order to remove it completely, it was necessary to remove the entire lung. This is apparently the first case in which an entire lung has been removed successfully at one stage. 600 South Kingshighway.
Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome
Authors: Xin Wang, Yingjun Zhao, Xiaofei Zhang, Hedieh Badie, Ying Zhou, Yangling Mu, Li Shen Loo, Lei Cai, Robert C Thompson, Bo Yang, Yaomin Chen, Peter F Johnson, Chengbiao Wu, Guojun Bu, William C Mobley, Dongxian Zhang, Fred H Gage, Barbara Ranscht, Yun-wu Zhang, Stuart A Lipton, Wanjin Hong, Huaxi Xu
Journal: Nature Medicine (2013)
T-cell changes after a short-term exposure to maraviroc in HIV-infected patients are related to antiviral activity
Authors: Ildefonso Pulido, Kawthar Machmach, María C. Romero-Sánchez, Miguel Genebat, Gema Mendez-Lagares, Ezequiel Ruiz-Mateos, Manuel Leal
Journal: Journal of Infection (2011)
Reply: Predictions of Hospital Mortality Rates
Authors: Michael Pine
Journal: Annals of Internal Medicine (1997)

Letters1 November 1997Reply: Predictions of Hospital Mortality RatesMichael Pine, MD, MBA, Marija Norusis, PhD, MPH, and Barbara Jones, MAMichael Pine, MD, MBAUniversity of Chicago Chicago, IL 60637Search for more papers by this author, Marija Norusis, PhD, MPHUniversity of Chicago Chicago, IL 60637Search for more papers by this author, and Barbara Jones, MAUniversity of Chicago Chicago, IL 60637Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-9-199711010-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We agree with Drs. Kutner and Rao that validation of a model done by using bootstrapping or split-sample methods is essential for obtaining an unbiased estimate of its goodness of fit. Because our database was large, and because the primary focus of our paper was the comparison of models of several different types, we did not include validation results in our paper. While evaluating hospital performance for large coalitions, we have found that c-statistics remain remarkably stable when models developed on 1 year of data are applied to a subsequent year. The data on acute myocardial infarction presented ... Author, Article, and Disclosure InformationAffiliations: University of Chicago Chicago, IL 60637 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1997Volume 127, Issue 9Page: 847KeywordsAcute myocardial infarctionAcute renal failureDatabasesDeath ratesMyocardial infarctionResearch laboratoriesShock Issue Published: 1 November 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Doctors as Delilahs: new ethics code causes row
Authors: S. Chapman
Journal: BMJ (1996)

While much of Australia lounges on the beach or watches cricket during the January holiday season, the Australian Medical Association has been furiously faxing press releases on a variety of public health issues from ocean sewage outfalls to hospital cuts and hydatid control. Last week it released its revised code of ethics, which includes for the first time an exception to the usual injunction to keep patients' confidences; apart from statutory exemptions this is now allowable “where the health of others is at risk” (see p 00).

AMA vice president Keith Woollard has handled most of the intense media interest. He has instanced cases such as pilots and crane operators with heart disease or …
Measles outbreak linked to Disney theme parks reaches five states and Mexico
Authors: M. McCarthy
Journal: BMJ (2015)

California’s Department of Public Health is warning anyone who has not been vaccinated against measles or who is unsure of their vaccination status to stay away from two Disney theme parks in Anaheim—Disneyland and Disney California Adventure Park—after scores of cases have been linked to the popular tourist destinations.

Officials said that since the end of December 59 cases of measles have been confirmed among California residents, 42 of which have been linked to initial exposure at the two parks. Five of the confirmed cases were in Disney employees. Some cases, however, have not been linked epidemiologically to the Disney exposures. The ages of the people …
Arthritis and angioimmunoblastic lymphadenopathy.
Authors: J C Duro
Journal: Annals of the Rheumatic Diseases (1984)

Arthropathy of calcium pyrophosphate deposition disease and of haemochromatosis SIR, The recent report by Bourqui et al.1 documents again the rather specific structural joint damage seen in the hand and the wrist in patients with calcium pyrophosphate dihy- drate (CPPD) crystal deposition disease.I would like to make several additional observations.As noted in our previous article2 as well as in one by Martel et al.,3 it is the distribution and the morphology of the articular abnormalities, especially in the hand and wrist, that are distinctive in radiographs in patients with CPPD crystal deposition disease.Although Bourqui et al. are indeed correct in their emphasis of the second and third metacarpophalangeal joints in this disease, their description of wrist alterations is incomplete.CPPD crystal deposition disease demonstrates a remarkable predilection for the radiocarpal joint in the wrist.Interosseous space narrowing between the distal radius and the scaphoid is most charac- teristic.Furthermore, the scaphoid moves proximally, lead- ing to scalloped erosion of the distal radius, and the lunate migrates distally, with joint space narrowing mainly iden- tified between it and the capitate.Separation, or dissocia- tion, of the scaphoid and the lunate is subsequently observed, perhaps related to crystal deposition in the interosseous ligament.At these articular locations as well as the metacar- pophalangeal joints (and elsewhere) several morphological characteristics distinguish the arthropathy of CPPD crystal deposition disease from osteoarthrosis: (1) multiple (and often large) subchondral rarefactions or cysts; (2) irregularity or 'crumbling' of the articular surface; (3) severe pro- gressive alterations that resemble those occurring in neuroarthropathy; (4) variable osteophyte formation; (5) single or multiple intra-articular osteocartilaginous bodies.In their article Bourqui et al. acknowledge prior reports that indicate the similarity of the arthropathy of CPPD crystal deposition disease to that of haemochromatosis.We have recently compared the radiographic abnormalities in these two diseases4 and have recognised differences between the two.In haemochromatosis, as compared with CPPD crystal deposition disease, findings include more prevalent narrowing of the metacarpophalangeal joint spaces, including those in the fourth and fifth digits, peculiar hook-like osteophytes on the radial aspect of the metacarpal heads, and less prominent separation of the scaphoid and the lunate.These radiographic differences indicate that the arthropathy of haemochromatosis is related to factors addi- tional to the presence of CPPD crystals.
INTRAVENOUS ADMINISTRATION OF INDOKLON<sup>®</sup>10% SOLUTION
Authors: KURT NUSSBAUM, ALBERT A. KURLAND
Journal: American Journal of Psychiatry (1963)

A group of 14 psychotic patients displaying depressive and schizo-affective symptomatology who had not responded to psychotropic drug therapies were treated with a 10% solution of Indoklon administered intravenously. The patients received a total of 85 treatments. Observations indicated that administration of the 10% solution brought about symptomatic improvement similar to that which would have been obtained with ECT. Administration of the 10% solution appears to be essentially free of the complaints associated with the 5% solution previously used.
Great Feuds in Medicine: Ten of the Liveliest Disputes Ever
Authors: Bernard Knight
Journal: BMJ (2001)

Hal Hellman 

John Wiley and Sons, £17.95, pp 237

ISBN 0 471 34757 4

Rating: ![Graphic][1]  ![Graphic][2] 

Progress in science and medicine is often accompanied by controversy, especially over claims to priority in publication, but some researchers seem to have had an antipathy born of pure professional jealousy. Hal Hellman has picked 10 from a large field, covering a timespan from William Harvey in the 17th century, right up to Gallo and Montagnier's dispute over HIV at the end of the 20th.

Perhaps few realise that Harvey's classic treatise on the circulation of the blood was banned by the censors in Britain and had …

 [1]: /embed/inline-graphic-1.gif
 [2]: /embed/inline-graphic-2.gif
Medical Marriages: Promises and Problems-Reply
Authors: Mary O. Sotile
Journal: JAMA (1997)

<h3>In Reply.</h3> —It is ironic that we received the Kellys' response to our article on the same day that we witnessed the demise of yet another young medical marriage. This couple's story was painfully familiar. Filled with positive intentions and expectations, they married during his third year of medical school. All went reasonably well for the first 2 years, but her resentment of his prolonged absences during his clinical years of training increased. Residency brought the hope of a more "normal" family life. But 3 years, 1 child, and too many missed family events later she proclaimed that the marriage had been a mistake. "I did not get married to spend my life alone. I don't care if you are a doctor. My question is what kind of husband and father will you be? The answer is 'not good enough.' I want a divorce." Our attempts to get this wife to reconsider
The Benefits of Exercise in Parkinson Disease
Authors: Liana S. Rosenthal, E. Ray Dorsey
Journal: JAMA Neurology (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Multiphasic Health Testing
Authors: David J. Lehman
Journal: JAMA (1977)

MULTIPHASIC health testing was called to the attention of American medicine in 1972 by the Department of Community Health of the American Medical Association. It consists of collecting specimens from humans and reporting test results—an incomplete health service. Periodic health appraisal in medical practices, schools, certain businesses, and industry has been recommended by physicians for many years. Particularly important were the cases of cancer, diabetes, glaucoma, and unsuspected cardiovascular disease which were discovered in persons who thought they were in excellent health. This form of testing involves fixed units, such as physicians' offices, testing centers, or mobile units capable of doing certain screening tests. The importance of physicians' evaluation and interpretation of test results has been emphasized and in no way replaces diagnosis and treatment by the physician. Recently multiphasic health testing centers have been opening, usually by business people, at a national rate of two a week in urban
Rationale for stopping cervical screening in women over 50.
Authors: W J Van Wijngaarden, I D Duncan
Journal: BMJ (1993)

To investigate whether the currently recommended age at which to stop cervical screening (64) can be lowered and what criteria should be used for safely doing so.Retrospective case analysis study.Dundee and Angus districts of Scotland.Women diagnosed as having cervical intraepithelial neoplasia and microinvasive or invasive cancer of the cervix in 1989 and 1990 (798 cases).History of cervical cytology results according to age (age groups of five years) and screening interval (three years and five years).Cervical intraepithelial neoplasia was most common in women under 45 (711 cases in women of 45 and under v 38 cases in those of 46 and over). Cervical intraepithelial neoplasia occurring de novo was not seen in women over 50 who had been screened every three years. Microinvasive or invasive cancer of the cervix was diagnosed in 26 women over 50. None of these women had participated adequately in the cervical screening programme.Cervical intraepithelial neoplasia typically occurs in younger women. All women over 50 with an adequate history of negative results on smear testing every three years may be safely discharged from further screening if these findings are confirmed in other populations.
Deregulation of the PP2A Inhibitor SET Shows Promising Therapeutic Implications and Determines Poor Clinical Outcome in Patients with Metastatic Colorectal Cancer
Authors: Ion Cristóbal, Raúl Rincón, Rebeca Manso, Cristina Caramés, Sandra Zazo, Juan Madoz-Gúrpide, Federico Rojo, Jesús García-Foncillas
Journal: Clinical Cancer Research (2014)

SET is an endogenous PP2A inhibitor that might represent a novel molecular target for antitumor therapy. The aim of this study was to evaluate the molecular effects of SET deregulation and its potential clinical significance in metastatic colorectal cancer (mCRC).We studied the biologic effects of SET on cell growth, colonosphere formation, caspase activity, PP2A activation status, and sensitivity to oxaliplatin and FTY720 treatments. Moreover, we analyzed SET expression by immunostaining in 242 patients with mCRC.SET deregulation promotes cell growth and colonosphere formation and inhibits PP2A, thereby impairing its antitumor effects. Moreover, SET reduces sensitivity to oxaliplatin in colorectal cancer cell lines, which is restored after FTY720 treatment. SET overexpression was detected in 24.8% (60 of 242) of patients with mCRC and determined significantly shorter overall (8.6 vs. 27 months; P < 0.001) and progression-free survival (7.1 vs. 13.7 months; P < 0.001), and poor response to oxaliplatin-based chemotherapy (P = 0.004). Interestingly, its prognostic value was particularly evident in patients younger than 70 years and in those harboring KRAS mutations.SET overexpression is a frequent event in mCRC that plays a potential oncogenic role associated with worse outcome and resistance to oxaliplatin. Moreover, this alteration defines a subgroup of patients who could benefit from therapies containing PP2A activators such as FTY720.
Medical Management of Aldosterone-Producing Adenomas
Authors: J.B. Ferriss
Journal: Annals of Internal Medicine (2000)

Letters4 April 2000Medical Management of Aldosterone-Producing AdenomasJ.B. Ferriss, MDJ.B. Ferriss, MDCork University Hospital; Cork, Ireland (Ferriss)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-7-200004040-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I read with interest Ghose and colleagues' report (1) on the medical management of aldosterone-producing adenomas. I was surprised, however, by the authors' statement that no data are available on the long-term medical management of this condition. The value of spironolactone in the long-term management of primary hyperaldosteronism was demonstrated more than 25 years ago (2, 3).In a study lasting up to 4 years, Brown and colleagues (2) showed that spironolactone controlled blood pressure in such patients. The average blood pressure reduction was similar to that found by Ghose and colleagues. In a follow-up study, spironolactone ...References1. Ghose RP, Hall PM, Bravo EL. Medical management of aldosterone-producing adenomas. Ann Intern Med. 1999;131:105-8. LinkGoogle Scholar2. Brown JJ, Davies DL, Ferriss JB, Fraser R, Haywood E, Lever AF, et al . Comparison of surgery and prolonged spironolactone therapy in patients with hypertension, aldosterone excess and low plasma renin. Br Med J. 1972;2:729-34. CrossrefMedlineGoogle Scholar3. Biglieri EG, Schambelan M. Management of primary aldosteronism.. In: Onesti G, Kim KE, Moyer JH, eds. Hypertension: Mechanisms and Management. New York: Grune and Stratton; 1973:493-8. Google Scholar4. Ferriss JB, Beevers DG, Boddy K, Brown JJ, Davies DL, Fraser R, et al . The treatment of low renin (primary) hyperaldosteronism. Am Heart J. 1978;96:97-109. CrossrefMedlineGoogle Scholar5. Pringe SD, Macfarlane PW, Isles CG, Cameron HL, Brown IA, Lorimer AR, et al . Regression of electrocardiographic left ventricular hypertrophy following treatment of primary hyperaldosteronism. J Hum Hypertens. 1988;2:157-9. MedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Cork University Hospital; Cork, Ireland (Ferriss) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoMedical Management of Aldosterone-Producing Adenomas Ranjan P. Ghose , Phillip M. Hall , and Emmanuel L. Bravo Medical Management of Aldosterone-Producing Adenomas Nor N. Chan Metrics 4 April 2000Volume 132, Issue 7Page: 593-594KeywordsAdenomasBlood plasmaBlood pressureImaging techniquesLeft ventricular hypertrophy Issue Published: 4 April 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
PCORI: odd name, important job, potential trouble
Authors: D. Kamerow
Journal: BMJ (2011)

Nitric oxide (NO) has been implicated in some of the central pathways engaged in the regulation of the sleep–wake cycle. The existence of nitric oxide synthase (NOS) in the cholinergic basal forebrain (BF) cells projecting to the cortex suggests a role for NO in the activation induced by the BF during arousal. We tested, in the anesthetized cat, the hypothesis that inhibition of NOS would decrease the ability of BF cholinergic fibers to induce cortical activation. In control conditions, BF stimulation evoked an awake-like EEG pattern (i.e., a decrease in the low-frequency–high-amplitude oscillatory activity and an increase in the high-frequency–low-amplitude activity). After blocking NOS activity, the capacity of BF stimulation to induce cortical activation was strongly impaired. Furthermore, voltammetric measurements of NO levels revealed an increase in cortical NO after BF stimulation, also blocked by systemic NOS inhibition. These results indicate that the blockade of NOS activity significantly reduces the ability of BF stimulation to induce changes in the EEG pattern and suggest a role for NO in the BF–cholinergic system implicated in arousal mechanisms.
THE COMMUNITY OF ORIGIN OF DIPHTHERIA, TYPHOID FEVER AND SCARLATINA.
Authors: E. O. BARDWELL
Journal: JAMA (1884)

It will not be expected that the writer of a paper with the above title will be a warm advocate of the theory of specific germs in the etiology of disease, it would hardly be consistent for him to evolve a little germ for each of the three diseases  the same ultimate elements, even for the sake of effect.  I do not wish to be understood as disparaging or discrediting the immense value which the microscope has been, and still is, to scientific medical research, but it is well enough to remember that any valuable acquisition is easily and frequently overvalued by enthusiasts.  The presence in the air of minute organisms has been known for years. A century since, when the microscope was a mere plaything, Goethe in his inimitable work Faust, made Mephistopheles say, from air, water, earth, in wet, dry, hot, cold, germs by thousands evolve themselves,
Impact of diffuse nitrate pollution sources on groundwater quality--some examples from Czechoslovakia.
Authors: V Benes, V Pĕkný, J Skorepa, J Vrba
Journal: Environmental Health Perspectives (1989)

In several regions of Czechoslovakia with intensive agricultural production, the correlation between the amount of nitrogen fertilizer applied and the nitrate content in groundwater has been recognized. Nitrate pollution of groundwater is considered to be the most serious source of nonpoint pollution in Czechoslovakia. A program of research into the effects of farming activities on groundwater quality in Czechoslovakia is under way on experimental fields (20 to 30 hectares) and, simultaneously, in regions in which shallow, vulnerable aquifers occur. The importance of the soil organic matter's stability for maintaining the groundwater quality is emphasized. Research based on nitrogen and organic carbon balance has shown that the restoration of a soil-groundwater system is a complicated process that usually requires changes in the extent and intensity of agricultural activities and consistent attention to the effects produced by natural conditions. Regional investigation of the impact of farming on shallow aquifers in the fluvial deposits of the Elbe River in Bohemia has proved the hydrochemical instability and vertical hydrochemical heterogeneity of these aquifers. The WASTEN deterministic model was used for modeling the transport and transformation of various types of inorganic fertilizers. The input data is based on laboratory and field measurements. Special topics are the verification of model calculations and the time and spatial variability of input data with respect to the unsaturated zone. The research results are being used for making regional and national agro-groundwater managerial schemes more precise, as well as for decision-making.
Lectin-like oxidized low-density lipoprotein (LDL) receptor (LOX-1)-mediated pathway and vascular oxidative injury in older-age rat renal transplants
Authors: Jan Hinrich Bräsen, Melina Nieminen-Kelhä, Denise Markmann, Ernst Malle, Wolfgang Schneider, Hans-Hellmut Neumayer, Klemens Budde, Friedrich C. Luft, Duska Dragun
Journal: Kidney International (2005)
Pharmacokinetics and Safety of Subcutaneous Immune Globulin (Human), 10% Caprylate/Chromatography Purified (IGIV-C) in Patients with Primary Immunodeficiency Disease (PID)
Authors: R. Levy, J. Chen, R. Roberts, S. Sorrells, D. Stark, J. Tracy, R.L. Wasserman, S. Gupta
Journal: Journal of Allergy and Clinical Immunology (2010)