tbuckley/cabot-search huggingface dataset:
The influence of substance P on the proliferation of peripheral blood lymphocytes from normal individuals and birch pollen-allergic patients
Authors: G. Nilsson, S. Rak, S. Ahlstedt
Journal: Allergy (1987)

We have studied the influence of substance P (SP) on the proliferative response of concanavalin A (ConA)‐activated peripheral blood lymphocytes from 16 birch pollen‐allergic patients, sampled before and during the pollen season, and from 15 normal individuals. The median response to ConA 3μg/ml in the presence of SP 10 ‐11 ‐10 ‐6 M, was in most instances within ±10% of the control value for cells from both healthy and atopic individuals. However, the individual differences were considerable. Analysis of the proliferative responses to ConA of the cells from the allergic patients sampled before and during season, revealed higher responses in the presence of 10 ‐6 than of 10 ‐2 M SP. This was in contrast to the findings in the normal individuals: only half of their cells showed such increased responses. This difference in response frequency was statistically significant between allergic patients before season and normal individuals ( P &lt; 0.05) and between allergic patients during season and normal individuals ( P &lt; 0.01). The difference in proliferation rate in the SP concentration interval, 10 ‐6 to 10 ‐7 M, for the cells from allergic patients, sampled both before and during season, was significantly different from the cells from healthy individuals ( P &lt; 0.03 and P &lt; 0.001 respectively). The cells sampled from four allergic subjects during the birch pollen season showed a more profoundly decreased response to ConA in the presence of SP 10 ‐8 M, compared with their cells sampled before season. Such responses were never seen with cells sampled before season and with cells from normal individuals. The results suggest an involvement of SP in the immunoregulation, particularly in patients exhibiting allergic reactions to birch pollen.
Bcl-2 Rescues T Lymphopoiesis, but Not B or NK Cell Development, in Common γ Chain–Deficient Mice
Authors: Motonari Kondo, Koichi Akashi, Jos Domen, Kazuo Sugamura, Irving L Weissman
Journal: Immunity (1997)

The common cytokine receptor γ chain (γc) is an indispensable subunit for the formation of lymphoid-related cytokine receptors, including IL-7 and IL-15 receptors, that mediate nonredundant or critical signals for the differentiation of T and B cells and natural killer (NK) cells, respectively. We introduced the bcl-2 transgene driven by Eμ or H-2K promoters into γc-deficient mice that lack all three lymphoid subclasses. The forced expression of Bcl-2 restored all stages of T lymphopoiesis, but not B or NK cell development, indicating that a primary function of γc-mediated signals in the T lineage might be to maintain cell survival. Therefore, the development of T, B, and NK cells may be influenced by distinct intracytoplasmic signaling cascades that are activated by coupling of γc-related receptors.
A Bedtime Story for Nephrologists: The Emperor's New Molly-Kules
Authors: Leonard B. Berman
Journal: JAMA (1976)

To the Editor.—  In a far-away country and in a far-away time there lived an emperor much beloved by his people, with good reason, for he had discovered many important things. But his spirit was not tranquil, for next to his kingdom was a strange and deadly place that the people called Yoo-Uree-Mia , an Indian word made popular by an early English explorer, Sir Richard the Bright. The vexing question had to do with the ruler of this strange place for nobody knew his name.  The emperor summoned his chief advisor to counsel him, and they sat broodingly before the fire. At last the advisor spoke, We have looked high and low with no results. Why not look in the middle? The emperor was delighted, and with just a little research, he proclaimed the enemy to be a female warrior called Middle Molly-Kule. Testimony was gathered and Molly (as her
Fibroblast Growth Factor Receptor 4 Regulates Tumor Invasion by Coupling Fibroblast Growth Factor Signaling to Extracellular Matrix Degradation
Authors: Nami Sugiyama, Markku Varjosalo, Pipsa Meller, Jouko Lohi, Marko Hyytiäinen, Sami Kilpinen, Olli Kallioniemi, Signe Ingvarsen, Lars H. Engelholm, Jussi Taipale, Kari Alitalo, Jorma Keski-Oja, Kaisa Lehti
Journal: Cancer Research (2010)

Aberrant expression and polymorphism of fibroblast growth factor receptor 4 (FGFR4) has been linked to tumor progression and anticancer drug resistance. We describe here a novel mechanism of tumor progression by matrix degradation involving epithelial-to-mesenchymal transition in response to membrane-type 1 matrix metalloproteinase (MT1-MMP, MMP-14) induction at the edge of tumors expressing the FGFR4-R388 risk variant. Both FGFR4 and MT1-MMP were upregulated in tissue biopsies from several human cancer types including breast adenocarcinomas, where they were partially coexpressed at the tumor/stroma border and tumor invasion front. The strongest overall coexpression was found in prostate carcinoma. Studies with cultured prostate carcinoma cell lines showed that the FGFR4-R388 variant, which has previously been associated with poor cancer prognosis, increased MT1-MMP-dependent collagen invasion. In this experimental model, knockdown of FGFR4-R388 or MT1-MMP by RNA interference blocked tumor cell invasion and growth in collagen. This was coupled with impaired phosphorylation of FGFR substrate 2 and Src, upregulation of E-cadherin, and suppression of cadherin-11 and N-cadherin. These in vitro results were substantiated by reduced MT1-MMP content and in vivo growth of prostate carcinoma cells after the FGFR4-R388 gene silencing. In contrast, knockdown of the alternative FGFR4-G388 allele enhanced MT1-MMP and invasive tumor cell growth in vivo and within three-dimensional collagen. These results will help to explain the reported association of the FGFR4-R388 variant with the progression and poor prognosis of certain types of tumors.
Revisiting the dogma of acne pathogenesis
Authors: I. Kurokawa, M. Ohyama
Journal: British Journal of Dermatology (2015)

Journal Article Revisiting the dogma of acne pathogenesis Get access I. Kurokawa, I. Kurokawa Department of Dermatology Acne Clinical Research Center Meiwa Hospital 4‐31 Agenaruo‐cho Nishinomiya Hyogo 663‐8186 Japan Search for other works by this author on: Oxford Academic Google Scholar M. Ohyama M. Ohyama Department of Dermatology Keio University School of Medicine Tokyo Japan Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 172, Issue 4, 1 April 2015, Page 851, https://doi.org/10.1111/bjd.13654 Published: 01 April 2015
Impaired Reproductive Development in Sons of Women Occupationally Exposed to Pesticides during Pregnancy
Authors: Helle R. Andersen, Ida M. Schmidt, Philippe Grandjean, Tina K. Jensen, Esben Budtz-Jørgensen, Mia B. Kjærstad, Jesper Bælum, Jesper B. Nielsen, Niels E. Skakkebæk, Katharina M. Main
Journal: Environmental Health Perspectives (2008)

The aim of this prospective study was to investigate whether occupational pesticide exposure during pregnancy causes adverse effects on the reproductive development in the male infants.Pregnant women employed in greenhouses in Denmark were consecutively recruited, and 113 mother-son pairs were included. The mothers were categorized as occupationally exposed (91 sons) or unexposed (22 sons) to pesticides during pregnancy. Testicular position and volume, penile length, and position of urethral opening were determined at 3 months of age using standardized techniques. Concentrations of reproductive hormones in serum from the boys were analyzed.The prevalence of cryptorchidism at 3 months of age was 6.2% [95% confidence interval (CI), 3.0-12.4]. This prevalence was considerably higher than among Danish boys born in the Copenhagen area (1.9%; 95% CI, 1.2-3.0) examined by the same procedure. Boys of pesticide-exposed mothers showed decreased penile length, testicular volume, serum concentrations of testosterone, and inhibin B. Serum concentrations of sex hormone-binding globulin, follicle-stimulating hormone, and the luteinizing hormone:testosterone ratio were increased compared with boys of nonexposed mothers. For individual parameters, only the decreased penile length was statistically significant (p = 0.04). However, all observed effects were in the anticipated direction, and a joint multivariate test showed that this finding had a p-value of 0.012.Our findings suggest an adverse effect of maternal occupational pesticide exposure on reproductive development in the sons despite current greenhouse safeguards and special measures to protect pregnant women.
Drug-related disease and the kidney.
Authors: H A Lee
Journal: BMJ (1979)

(5) No patient should be woken before 7 30 am. The traditional grounds for starting their day earlier are no more or less valid than those used to exclude women from all-male colleges and medical schools. Longer term, the educational changes that will be needed include a review of nursing and medical curricula to correct the balance between their scientific and experiential components. A new subject should be introduced into the curriculum: the social and psychological determinants of interactions between health professionals and patients, including harmful forms of care-giving and their causation. Both the qualifying examination (SRN, MB, BS, etc) and the specialist examinations (FRCS, MFCM, MRCP, MRCPsych, etc) should include obligatory questions on these topics. Departments for the study of staffpatient relationships will be needed in medical and nursing schools, and they might be funded perhaps by the royal colleges, the Patients' Association, the TUC, and the Institute of Health Service Administrators. The significance of grief, illness, admission to hospital, and surgical procedures should be discussed in general textbooks, and, for example, accounts of conditions such as glaucoma, emphysema, or colostomy should include their effects on the patient and his family, and on his nurse and doctor. Conclusions
Migrating Pneumonia*†
Authors: WILLIAM B. FAULKNER
Journal: Annals of Internal Medicine (1933)

Article1 April 1933Migrating PneumoniaCertain Mechanical Factors in Its Production, Prevention, and TreatmentWILLIAM B. FAULKNER JR., M.D., AIME N. FREGEAU, M.D., EDWARD C. FAULKNER, M.D.WILLIAM B. FAULKNER JR., M.D.Search for more papers by this author, AIME N. FREGEAU, M.D.Search for more papers by this author, EDWARD C. FAULKNER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-6-10-1289 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA close study of postoperative massive collapse of the lung (pulmonary atelectasis) indicates its marked similarity to pneumonia. These two conditions have many characteristics in common and, from the study of atelectasis, we may draw certain deductions relative to pneumonia.As observed by Norris and Landis,1"practically every case of pneumonia spreads to some extent. In some cases it slowly extends spreading from lobe to lobe by contiguity; in others the process apparently develops afresh at different points in the same or the opposite lung", and, "in double pneumonia, both bases may be affected simultaneously or the apex of one...Bibliography1 NORRISLANDIS GWHR: Diseases of the chest and the principles of physical diagnosis, 3 Ed., 1924, W. B. Saunders Co., Philadelphia, p. 464. Google Scholar2 FAULKNER WB: Internal drainage; its application in pulmonary suppuration, Jr. Am. Med. Assoc., 1930, xcv, 1325-1328. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: WILLIAM B. FAULKNERJR., M.D.; AIME N. FREGEAU, M.D.; EDWARD C. FAULKNER, M.D.Affiliations: San Francisco, California*Read before the American College of Physicians, San Francisco, California, April 8, 1932.†From the Department of Surgery, University of California Medical School, San Francisco; Department of Medicine, French Hospital, San Francisco; and Department of Thoracic Surgery, St. Mary's Hospital, San Francisco. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1933Volume 6, Issue 10Page: 1289-1297KeywordsHospital medicineLungsPneumoniaThoracic surgery ePublished: 1 December 2008 Issue Published: 1 April 1933 PDF downloadLoading ...
Haploinsufficiency of NSD1 causes Sotos syndrome
Authors: Naohiro Kurotaki, Kiyoshi Imaizumi, Naoki Harada, Mitsuo Masuno, Tatsuro Kondoh, Toshiro Nagai, Hirofumi Ohashi, Kenji Naritomi, Masato Tsukahara, Yoshio Makita, Tateo Sugimoto, Tohru Sonoda, Tomoko Hasegawa, Yasuaki Chinen, Hiro-aki Tomita, Akira Kinoshita, Tsuyoshi Mizuguchi, Koh-ichiro Yoshiura, Tohru Ohta, Tatsuya Kishino, Yoshimitsu Fukushima, Norio Niikawa, Naomichi Matsumoto
Journal: Nature Genetics (2002)
Human Papilloma Virus DNA and p53 Mutation Analysis on Bladder Washes in Relation to Clinical Outcome of Bladder Cancer
Authors: Paula M.J. Moonen, Judith M.J.E. Bakkers, Lambertus A.L.M. Kiemeney, Jack A. Schalken, Willem J.G. Melchers, J. Alfred Witjes
Journal: European Urology (2006)
Up regulated expression of tumour necrosis factor converting enzyme in peripheral monocytes of patients with early systemic sclerosis
Authors: T Bohgaki, Y Amasaki, N Nishimura, M Bohgaki, Y Yamashita, M Nishio, K-i Sawada, S Jodo, T Atsumi, T Koike
Journal: Annals of the Rheumatic Diseases (2005)

<b>Background:</b> Systemic sclerosis (SSc) is accompanied by abnormalities in humoral and cellular immune systems. <b>Objective:</b> To determine the genes specifically expressed in the immune system in SSc by analysis of the gene expression profile of peripheral blood mononuclear cells (PBMC) from patients with SSc, including those treated with haematopoietic stem cell transplantation (HSCT). Additionally, to investigate the clinical significance of the up regulation of tumour necrosis factor α (TNFα) converting enzyme (TACE). <b>Methods:</b> PBMC from patients with SSc (n = 23) and other autoimmune diseases (systemic lupus erythematosus (SLE, n = 16), rheumatoid arthritis (RA, n = 29)), and from disease-free controls (n = 36) were examined. Complementary DNA arrays were used to evaluate gene expression of PBMC, in combination with real time quantitative polymerase chain reactions. TACE protein expression in PBMC was examined by fluorescence activated cell sorter (FACS). <b>Results:</b> In patients with SSc 118 genes were down regulated after HSCT. Subsequent comparative analysis of SSc without HSCT and healthy controls indicated SSc-specific up regulation for three genes: monocyte chemoattractant protein-3 (p = 0.0015), macrophage inflammatory protein 3α (p = 0.0339), and TACE (p = 0.0251). In the FACS analysis, TACE protein was mainly expressed on CD14<sup>+</sup> monocytes both in patients with SSc and controls. TACE expression on CD14<sup>+</sup> cells was significantly increased in patients with early SSc (p = 0.0096), but not in those with chronic SSc, SLE, or RA. TACE protein levels in SSc monocytes correlated with the intracellular CD68 levels (p = 0.0016). <b>Conclusions:</b> Up regulation of TACE expression was a unique profile in early SSc, and may affect the function of TNFα and other immunoregulatory molecules.
Health System Factors and Antihypertensive Adherence in a Racially and Ethnically Diverse Cohort of New Users
Authors: Alyce S. Adams, Connie Uratsu, Wendy Dyer, David Magid, Patrick O’Connor, Arne Beck, Melissa Butler, P. Michael Ho, Julie A. Schmittdiel
Journal: JAMA Internal Medicine (2012)

Background:The purpose of this study was to identify potential health system solutions to suboptimal use of antihypertensive therapy in a diverse cohort of patients initiating treatment.Methods: Using a hypertension registry at Kaiser Permanente Northern California, we conducted a retrospective cohort study of 44 167 adults (age, Ն18 years) with hypertension who were new users of antihypertensive therapy in 2008.We used multivariate logistic regression analysis to model the relationships between race/ ethnicity, specific health system factors, and early nonpersistence (failing to refill the first prescription within 90 days) and nonadherence (Ͻ80% of days covered during the 12 months following the start of treatment), respectively, controlling for sociodemographic and clinical risk factors.Results: More than 30% of patients were early nonpersistent and 1 in 5 were nonadherent to therapy.Nonwhites were more likely to exhibit both types of suboptimal medication-taking behavior compared with whites.In logistic regression models adjusted for sociodemo-graphic, clinical, and health system factors, nonwhite race was associated with early nonpersistence (black: odds ratio, 1.56 [95% CI, 1.43-1.70];Asian: 1.40 [1.29-1.51];Hispanic: 1.46 [1.35-1.57])and nonadherence (black: 1.55 [1.37-1.77];Asian: 1.13 [1.00-1.28];Hispanic: 1. 46 [1.31-1.63]).The likelihood of early nonpersistence varied between Asians and Hispanics by choice of first-line therapy.In addition, racial and ethnic differences in nonadherence were appreciably attenuated when medication copayment and mail-order pharmacy use were accounted for in the models.Conclusions: Racial/ethnic differences in medicationtaking behavior occur early in the course of treatment.However, health system strategies designed to reduce patient co-payments, ease access to medications, and optimize the choice of initial therapy may be effective tools in narrowing persistent gaps in the use of these and other clinically effective therapies.
Autoradiographic mapping of calcitonin gene-related peptide receptors in human and guinea pig hearts.
Authors: M O Coupe, J C Mak, M Yacoub, P J Oldershaw, P J Barnes
Journal: Circulation (1990)

Calcitonin gene-related peptide (CGRP) is a 37-amino acid peptide that is a potent coronary vasodilator. Although CGRP is found in high concentrations around coronary arteries, its precise function in the control of coronary vasomotor tone remains unclear. We studied the distribution of specific receptors for CGRP in guinea pig and human hearts and found that the highest concentration of specific receptors for CGRP was in the major coronary arteries, which is consistent with the hypothesis that CGRP is implicated in control of coronary vasomotor tone. Areas of coronary artery with atheroma contained significantly decreased (158 +/- 35 grains/1,000 microns 2 tissue, n = 3) binding sites compared with binding sites in normal arteries (266 +/- 10 grains/1,000 microns 2 tissue, n = 11; p less than 0.001, t test). The decrease in receptors for CGRP around atheroma may predispose these vessels to coronary spasm.
Bipolar Children: Cutting-Edge Controversy, Insights, and Research
Authors: Mary Burke
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Relationship of Locus of Control to Physical Activity Among People With and Without Diabetes
Authors: Edward W Gregg, Andrea M Kriska, KM Venkat Narayan, William C Knowler
Journal: Diabetes Care (1996)

OBJECTIVE To examine the relationship between locus of control (LOC) (internal and external) and physical activity in Pima Indians and to determine whether this relationship is affected by the presence of diabetes. RESEARCH DESIGN AND METHODS A population-based sample of 580 Pima Indians was recruited from an ongoing research study. LOC was measured on a 1–40 modified Rotter scale, and past year total physical activity (leisure and work physical activity levels combined) was measured by interviewer-administered questionnaire. RESULTS Among both men and women without diabetes, individuals with an internal LOC (score 1–16) were significantly (P &amp;lt; 0.01) more active than those with an external (score 17–40) LOC (70 vs. 30 median metabolic equivalent [MET] hours per week for men: 12 vs. 5 median MET hours per week for women). Controlled for age and BMI, an internal LOC was significantly associated with a higher level of physical activity among men (P = 0.04) and women (P = 0.001) without diabetes, but not among those with diabetes. CONCLUSIONS Nondiabetic Pima Indians with an internal LOC are more physically active than those with an external LOC. Enhancing perceptions of internal control may influence physical activity and thus have implications for diabetes prevention.
Tobacco companies are evading FDA ban on "light" cigarette labeling, finds study
Authors: S. Mayor
Journal: BMJ (2013)

Smokers in the United States can easily identify “light” cigarettes by the color coding that tobacco companies have added to packs since the Food and Drug Administration banned the use of words such as “low” or “mild” on packaging and advertising, a study has found.1

Since June 2010, tobacco companies have been banned from using explicit or implicit descriptors that convey messages of reduced risk unless they can prove to the FDA that the product significantly reduces the risk of tobacco related disease. 

“Light” cigarettes have ventilation holes that allow air to mix with smoke, which companies said would limit the smoke inhaled. But …
Follow up for more than 10 years in patients transplanted for autoimmune hepatitis: histological changes precede clinical and biological criteria of recurrence
Authors: J. Duclos-Vallee, M. Sebagh, K. Riffai, M. Hurtova, V. Karam, C. Johanet, C. Feray, H. Bismuth, D. Samuel
Journal: Journal of Hepatology (2001)
441 The influence of interleukin- 10 promoter gene polymorphism on the occurrence of non hodgkin lymphoma (NHL) in subjects infected with hepatitis C virus (HCV)
Authors: M. Persico, M. Capasso, E. Persico, V. La Mura, M. Masarone, M. Svelto, A. Iolascon
Journal: Journal of Hepatology (2006)
The Hôpital Saint Antoine and Hôpital Paul Brousse experience of anti-M4 and anti-M9 antibodies as markers of severity of primary biliary cirrhosis
Authors: L. Dubel, N. Boulay-Stref, R. Poupon, O. Farges, J.C. Homberg, C. Johanet
Journal: Journal of Hepatology (1995)
Long term care will "implode" unless personal care comes free
Authors: K. Burke
Journal: BMJ (2003)

The long term care situation across the United Kingdom will “implode,” unless the rest of the United Kingdom follows Scotland's lead and funds personal care for sick and disabled people, official advisers have warned.

Nine of the original 12 royal commissioners on long term care for the elderly have called on the English, Welsh, and Northern Irish governments to scrap the “artificial” distinction between nursing and the intimate help some patients need with dressing, washing, eating, or managing their continence.

Since July 2002, elderly people in Scotland have been getting the personal and nursing care they need free of charge ( BMJ 2002;324: 1542), whereas in the rest of …