tbuckley/cabot-search huggingface dataset:
Dream of a Suicide
Authors: Jo Persoon-Gundy
Journal: Annals of Internal Medicine (2014)

Ad Libitum1 April 2014Dream of a SuicideJo Persoon-Gundy, MDJo Persoon-Gundy, MDFrom Burbank, California.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M14-0039 Audio Reading - “Dream of a Suicide” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Dream of a Suicide," by J. Persoon-Grundy. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail What does it mean?That I dreamed youtall and whole.Strong, straight and well,with a practiced patter:sharp as a cutting remark.You would think it was funny, too,that you were gay in my dream.Completely, limp-wristedly,a flamingo in style,violently fashionable.You wore a silver jumpsuit,like a mirrored disco ball,and had a bowl haircut,(What were you thinking?)and grinned like a shark.What does it mean?That I dreamed you a future,and it was FABulous.Did I dream you an afterlife?A beauty school dropout, frankie avalon heaven?And oh, ... Author, Article, and Disclosure InformationAffiliations: From Burbank, California.Current Author Address: Jo Persoon-Gundy, MD; e-mail, [email protected]com. PreviousarticleNextarticle Advertisement Audio Reading - “Dream of a Suicide” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Dream of a Suicide," by J. Persoon-Grundy. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 1 April 2014Volume 160, Issue 7Page: 498KeywordsForecastingSuicide ePublished: 1 April 2014 Issue Published: 1 April 2014 Copyright & PermissionsCopyright © 2014 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Epidemiology of pollution‐induced airway disease: urban/rural differences in East and West Germany
Authors: T. NICOLAI
Journal: Allergy (1997)

Nicolai T. Epidemiology of pollution‐induced airway disease: urbadrural differences in East and West Germany. The prevalence of asthma and allergic disorders was assessed in 9–11 year‐old children in Leipzig and Halle in East Germany, as well as in Munich, West Germany. Both East German cities are heavily polluted due to private burning of coal and industrial emissions, while Munich has low smoke emissions but heavy road traffic. All fourth grade pupils in Munich were compared with those in Leipzig and Halle. Non‐specific airway disease (bronchitis), cough, and autudwinter nasal symptoms were most prevalent in Leipzig and Halle. Hay fever and skin test reactivity to aeroallergens were higher in West Germany compared with East Germany. Furthermore, the prevalence of asthma was also higher in the West German study area. Increased skin prick test reactivity in the West explained the increased prevalence of asthma. Longitudinal analysis showed increased respiratory symptoms on days with high mean levels of sulphur dioxide and oxides of nitrogen, as well as on days with a high peak level of 10 μ respirable particles (PM10) in East Germany. The effects of these pollutants were additive. Exposure to heavy road traffic in Munich was related to decreased pulmonary function and non‐specific airway symptoms, but not to allergic sensitization and asthma.
Home Blood Glucose Monitoring As an Aid in Diabetes Management
Authors: Jay S Skyler, Ilene A Lasky, Denise L Skyler, Euan G Robertson, Daniel H Mintz
Journal: Diabetes Care (1978)

Home blood glucose monitoring, using Dextrostix and an Eyetone meter, has been utilized in several subcategories of patients with insulin-dependent diabetes mellitus. These include pregnant patients, anephric patients, patients undergoing weight reduction, patients with altered renal threshold for glucose reabsorption, and patients in whom diabetic regulation is difficult. Patients monitored home blood glucose continually (on a daily basis), intermittently, or only for particular problems or symptoms. Such monitoring can be practically accomplished in a manner acceptable to patients. Motivation, compliance with protocol, and an understanding of the objectives of the program are essential on the part of the patient. Home blood glucose monitoring, however, can provide an insight diabetes regulation that cannot be attained in any other way and can greatly facilitate regulation of diabetes. Such home blood glucose monitoring may increase the likelihood of achievement of a degree of control approximating euglycemia.
Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite
Authors: Alfonso Abizaid, Zhong-Wu Liu, Zane B. Andrews, Marya Shanabrough, Erzsebet Borok, John D. Elsworth, Robert H. Roth, Mark W. Sleeman, Marina R. Picciotto, Matthias H. Tschöp, Xiao-Bing Gao, Tamas L. Horvath
Journal: Journal of Clinical Investigation (2006)

The gut hormone ghrelin targets the brain to promote food intake and adiposity. The ghrelin receptor growth hormone secretagogue 1 receptor (GHSR) is present in hypothalamic centers controlling energy metabolism as well as in the ventral tegmental area (VTA), a region important for motivational aspects of multiple behaviors, including feeding. Here we show that in mice and rats, ghrelin bound to neurons of the VTA, where it triggered increased dopamine neuronal activity, synapse formation, and dopamine turnover in the nucleus accumbens in a GHSR-dependent manner. Direct VTA administration of ghrelin also triggered feeding, while intra-VTA delivery of a selective GHSR antagonist blocked the orexigenic effect of circulating ghrelin and blunted rebound feeding following fasting. In addition, ghrelin- and GHSR-deficient mice showed attenuated feeding responses to restricted feeding schedules. Taken together, these data suggest that the mesolimbic reward circuitry is targeted by peripheral ghrelin to influence physiological mechanisms related to feeding.
THE ESSENTIAL OF INSANITY.
Authors: J. SANDERSON CHRISTISON
Journal: JAMA (1895)

If by insanity we simply mean more or less deviation from the free normal action of the mind, without regard to cause, then, indeed, no mortal is constantly free from it. For as mental activity, in degree and range, is a measure of physical tone and proportion, especially of the brain, it is quite evident the accidents of existence preclude a constant normal. But the term insanity, to the popular mind implies the state of personal irresponsibility and the question in regard to a particular act, is the proof of the existence of this state. The law, with reference to a specific act, simply demands, Was he sane or was he not? implying by the question either a fracture of mental integrity or a degree of derangement beyond which responsibility justly ceases. It is quite clear that from a practical standpoint, we can not hold to the position that all
Serum amyloid A (SAA3) produced by rabbit synovial fibroblasts treated with phorbol esters or interleukin 1 induces synthesis of collagenase and is neutralized with specific antiserum.
Authors: T I Mitchell, C I Coon, C E Brinckerhoff
Journal: Journal of Clinical Investigation (1991)

We report that nucleic acid sequence analysis of a full-length cDNA clone for a rabbit serum amyloid A (SAA)-like protein has identified this protein as more closely related to SAA3 than to SAA1. SAA3 induced collagenase synthesis in rabbit synovial fibroblasts, and immune IgG raised against this SAA protein abrogated the induction. Using antisera to immunoprecipitate biosynthetically labeled 3H-SAA and 3H-collagenase from culture medium, we compared the levels of SAA and collagenase synthesized by cultures of rabbit fibroblasts at early passage (passages 3-6) with those synthesized by late passage cells (passage 16). Comparatively high levels of both proteins were produced constitutively by fibroblasts at low passage. With increasing passage, levels of both proteins drop so that by passage 16, constitutive production of SAA and collagenase was only approximately 15-20% that of passage 3 cells. Cells at low passage could be readily stimulated with phorbol myristate acetate (PMA) or interleukin 1 (IL-1) to synthesize increased amounts of both SAA and collagenase. In passage 5 cells treated with PMA, we detected increased SAA mRNA by 1.5 h and collagenase mRNA by 5 h. However, older passage cells were more refractory to stimulation and required longer induction times. We suggest that SAA3 may be expressed by fibroblasts at sites of acute inflammation or injury, and that elevated levels of SAA3 may signify "activated" fibroblasts which are already producing increased amounts of collagenase constitutively and which are predisposed to further stimulation.
Abstract A38: Overexpression of FAT1 in human GBM (glioblastoma multiforme) and high-grade glioma cell lines
Authors: Bhawana Dikshit, Kunzang Chosdol, Subrata Sinha
Journal: Cancer Research (2011)

Abstract FAT1, a human homologue of Drosophila tumor suppressor gene fat, is located on chromosome 4q35 in humans. In Drosophila, fat gene is known to be acting as an apical regulator of the tumor suppressor signaling, Salvador-Warts-Hippo (SWH) pathway. In mammalian cells, FAT1 is known to have a role in cell migration. The role of FAT1 in cancer is not clear and not much literature is available. In this study, we analyzed the expression of FAT1 in GBM (glioblastoma multiforme, grade IV glioma) samples at both mRNA and protein levels by means of q-PCR and immunohistochemistry. Herein, we demonstrate that 51.4% (18/35) of GBM samples had high expression of FAT1 mRNA, and 53.33% (8/15) of GBM samples had high FAT1 protein expression. We also checked the expression of FAT1 in glioma cell lines by q-PCR. Of the six glioma cell lines analyzed, four were GBM cell lines (U87MG, A172, U373MG and T98G) and two were astrocytoma grade 3 cell lines (GOS3 and SW1088). All GBM cell lines had high FAT1 expression while grade 3 cell lines had no or very low FAT1 expression. Since U87MG had maximum FAT1 expression we chose this cell line to study the effects of FAT1 knockdown by siRNA. FAT1 knockdown resulted in altered morphology and reduced migration of U87MG cells as compared to control siRNA treated cells. Since FAT1 is known to be an apical regulator of hippo pathway in Drosophila, we checked the expression of hippo pathway molecules by q-PCR and found that Mst2 (mammalian homolog of Drosophila hippo) expression was reduced up to 65% while other molecules like LATS and YAP were not altered at mRNA level. Considering the fact that regulation of SWH pathway primarily occurs at posttranslational level and depends upon phosphorylation status of the molecules, we are in process of analyzing the expression of these molecules at protein level and their phosphorylation status using phosphospecific antibodies, which would provide better understanding of the role of FAT1 in influencing SWH pathway. Since FAT1 is overexpressed in 50% of GBM samples studied and also found to have high expression in high-grade glioma cell lines as compared to low-grade glioma cell lines, it might act as an oncogene and may be involved in progression from low-grade to high-grade glioma. Thus, we propose FAT1 as a novel molecular target for therapeutic intervention in glioma. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the Second AACR International Conference on Frontiers in Basic Cancer Research; 2011 Sep 14-18; San Francisco, CA. Philadelphia (PA): AACR; Cancer Res 2011;71(18 Suppl):Abstract nr A38.
Changing patterns of communicable disease in England and Wales: part II-Disappearing and declining diseases.
Authors: N S Galbraith, P Forbes, R T Mayon-White
Journal: BMJ (1980)

Many of the traditional infectious diseases have declined or even disappeared and others have shown a change in their epidemiology in England and Wales over the past 20 years.Diphtheria, poliomyelitis, and smallpox have almost disappeared, while brucellosis, dysentery, hepatitis, measles, staphylococcal in- fections, tetanus, and tuberculosis have declined.There have been other changes in the epidemiology of some of these diseases.Staphylococcal infections in hospitals have decreased dramatically although there is no continuous quantitative measure of this condition. DiphtheriaAfter the introduction of mass immunisation against diphtheria in 1940 notifications declined rapidly from nearly 50 000 in 1940 to under 1000 in 1950.By 1960 this figure had dropped to 49 and by 1978 to nil (table I).Since the early 1960s national TABLE I-Disappearing itnfectious diseases, England and Wales 1960-79 Poliomyelitis Diphtheria notifications Smallpox Notifi
Clinical Study with Bleomycin.
Authors: S. Shastri
Journal: Annals of Internal Medicine (1971)

Meeting Abstracts1 May 1971Clinical Study with Bleomycin.S. Shastri, M.D., Robert E. Slayton, M.D., Janet Wolter, M.D., Charles P. Perlia, M.D., F.A.C.P.S. Shastri, M.D.Search for more papers by this author, Robert E. Slayton, M.D.Search for more papers by this author, Janet Wolter, M.D.Search for more papers by this author, Charles P. Perlia, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-74-5-837_4 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptBleomycin, an antibiotic derived fromStreptomyces verticillus, has recently become available for clinical trial in this country. Over 50 patients admitted to Rush-Presbyterian-St. Luke's Medical Center Hospital, Chicago, Ill., with various types of disseminated cancer were studied. An initial testing dose of 15 mg of the drug, followed by 30 mg twice a week, intravenously or intramuscularly, was administered. Objective regression of the tumors was noted in patients with epidermoid carcinoma of the head and neck region, uterine cervix, Hodgkin's disease and other lymphomas, embryonal carcinoma of the testes, and in a patient with lymphangiosarcoma of the arm. Serial biopsies... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: S. Shastri, M.D.; Robert E. Slayton, M.D.; Janet Wolter, M.D.; Charles P. Perlia, M.D., F.A.C.P.Affiliations: Chicago, Ill. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1971Volume 74, Issue 5 Page: 837-838 Keywords Antibiotics Biopsy Cervix Clinical trials Drugs Head and neck tumors Hodgkin lymphoma Lymphoma Testes ePublished: 1 December 2008 Issue Published: 1 May 1971 PDF downloadLoading ...
Does low entry of cystic duct predispose to stones in the common bile duct?
Authors: P. C. Bornman, R. E. Kottler, J. Terblanche, A. N. Kingsnorth, J. E. Krige, I. N. Marks
Journal: BMJ (1988)

There was no apparent failure of the humoral response to malaria associated with infection with HIV, but as we observed only patients aged 12 and above a study of the acquisition of immunity in infants positive and negative for HIV antibody might be of interest, as would a study in patients with terminal AIDS.Twenty patients had symptoms suggestive of malaria but gave negative results for parasites and positive results for HIV antibody.This suggests that many patients with HIV infection may be presenting with an illness similar clinically to malaria before AIDS related complex or AIDS is recognisable.We thank the hospital doctors for referring their patients to us and the Ministry of Health for permission to publish the findings of this study.The research centre is funded by the government of the Republic of Zambia and by the joint United Nations Development Programme, World Bank, and World Health Organisation special programme for research and training in tropical diseases.
THE QUESTION OF HOMOPLASTIC SKIN GRAFTING
Authors: H. M. TRUSLER
Journal: JAMA (1935)

The homoplastic transplantation of skin, in other words, the transference of skin from one individual to another, is a procedure about which there is much controversy. The subject receives such apparently favorable publicity that most laymen and likewise many physicians assume that the homoplastic transplanting of skin is a successful procedure, another accomplishment of modern science. The fact is that practically all recent scientific observation has proved that the homoplastic skin graft is unsuccessful. These rather disconcerting statements deserve an explanation which we hope to give after reviewing a few salient facts. Practically speaking, skin grafting of any type was first accepted as a surgical procedure in 1869 after Reverdin<sup>1</sup>had reported his success with "pinch grafts." Following this, the various types of split skin and whole thickness skin grafts were described by Ollier, Thiersch, Wolfe and Krause. Along with the numerous reports of success with autoplastic transplants of
427 TREATMENT OF HEPATITIS C RECURRENCE AFTER LIVER TRANSPLANTATION: GENDER ISSUE ON THERAPY OUTCOME
Authors: V. Giannelli, C. Lucidi, M. Giusto, F.R. Ponziani, M. Pompili, R. Viganò, R.M. Iemmolo, F.M. Donato, M. Rendina, P. Toniutto, L. Pasulo, S. Fagiuoli, M.C. Morelli, E. de Martin, L. Miglioresi, D. di Paolo, M. Merli
Journal: Journal of Hepatology (2011)
Predicting Death in Patients Hospitalized for Community-acquired Pneumonia
Authors: Barry M. Farr, Andrew J. Sloman, Michael J. Fisch
Journal: Annals of Internal Medicine (1991)

To validate a previously reported discriminant rule for predicting mortality in adult patients with primary community-acquired pneumonia and to determine which factors available at hospital admission predict a fatal outcome among such patients.Historical cohort study.University hospital.Adults admitted to the hospital for community-acquired pneumonia.Using stepwise logistic regression, we analyzed prognostic factors (data available at admission and recorded in the medical record) that showed a univariate association with mortality. The predictive values of three discriminant rules were measured to validate the results of a previous study.Of 245 patients, 20 (8.2%) died. Of 42 prognostic factors identified in previous studies, 8 were associated with mortality, but only a respiratory rate of 30/min or more, a diastolic blood pressure of 60 mm Hg or less, and a blood urea nitrogen of more than 7 mmol/L remained predictive in the multivariate analysis. A discriminant rule composed of these three variables was 70% sensitive and 84% specific in predicting mortality, yielding an overall accuracy of 82%.Tachypnea, diastolic hypotension, and an elevated blood urea nitrogen were independently associated with death from pneumonia in our study, confirming the value of a previously reported discriminant rule from the British Thoracic Society. This rule may be useful in triage decisions because it identifies high-risk patients who may benefit from special medical attention.
Usefulness of lower gastrointestinal endoscopy on suspicion of an iatrogenic sigmoid perforation caused by an aorto-bifemoral prosthetic bypass
Authors: B. Mangiavillano, G. Mezzi, P. Testoni
Journal: Endoscopy (2008)

Prosthetic graft infection occurs in up to 6.0 % of patients who undergo aortic surgery and is associated with a high mortality rate (20 – 75 %) [1]. Vascular-enteric fistulas (VEF) most commonly involve the third or fourth portion of the duodenum (87 % of cases), rarely the colon (2 %) [2] [3].
Improved regional blood flow and wall motion six months following transmyocardial laser revascularization
Authors: R.M. Reul, S.J. Ferzoco, U. Sayeed-Shah, R.G. Laurence, T. Aretz, S.C. Reimold, S.F. Aranki, L.H. Cohn
Journal: Journal of the American College of Cardiology (1998)
Alcohol and Pancreatitis
Authors: ALAN DAVIS
Journal: Annals of Internal Medicine (1971)

Letters, Comments, and Corrections1 August 1971Alcohol and PancreatitisALAN DAVIS, M.D.ALAN DAVIS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-75-2-320_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The editorial note by Drs. H. D. Janowitz and Michael Bayer (Ann Intern Med 74:444-445, 1971) on alcohol and pancreatitis rightly stressed that although many etiological factors are well recognized, little is known about the pathogenesis of pancreatitis. They reason that it is likely that alcohol has a direct effect on the pancreas, and, indeed, this has been shown in the rat by two groups of workers (1, 2). It therefore is not surprising that in an isolated and somewhat unphysiological preparation alcohol has been shown to inhibit pancreatic secretion to some extent.One of the mechanisms...References1. ORREGO-MATTENAVIAFERES HEA: Ethanol ingestion and incorporation of P32 into phospholipids of pancreas in the rat. Gastroenterology 56:280-285, 1969 CrossrefMedlineGoogle Scholar2. PIROLATAYLORDAVIS RKA: Effects of ethanol, Dl-ethionine, and protein deficiency on rat pancreas. Amer J Dig Dis 15:21-30, 1970 CrossrefMedlineGoogle Scholar3. PIROLADAVIS RA: Effect of ethyl alcohol on sphincteric resistance at the choledocho-duodenal junction in man. Gut 9:557-560, 1968 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ALAN DAVIS, M.D.Affiliations: The Prince Henry Hospital Little Bay, New South Wales Australia PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAlcoholism and Malnutrition 1 August 1971Volume 75, Issue 2Page: 320-320KeywordsAlcoholsPancreasPancreatitisPathogenesis ePublished: 1 December 2008 Issue Published: 1 August 1971 PDF downloadLoading ...
Effect of intragastric pH on antral gastrin and somatostatin release in anaesthetised, atropinised duodenal ulcer patients and controls.
Authors: S L Jensen, J J Holst, L A Christiansen, M H Shokouh-Amiri, M Lorentsen, H Beck, H E Jensen
Journal: Gut (1987)

The synchronous change in the antral release of gastrin and somatostatin into a vein draining the stomach was studied during acidic and alkaline intragastric pH in six anaesthetised duodenal ulcer patients and six controls after atropinisation. No differences in the basal secretion of gastrin and somatostatin were observed among the two groups. Alkaline as well as acidic intragastric pH had no effect on the antral release of somatostatin in duodenal ulcer patients and controls. In contrast, alkaline intragastric pH was associated with a significantly higher antral gastrin release in duodenal ulcer patients than in controls. Acidic intragastric pH was associated with a significantly smaller inhibition of antral gastrin release in duodenal ulcer patients than in controls. These results suggest that atropinised anaesthetised duodenal patients release gastrin abnormally in the presence of acidic or alkaline intragastric pH and that any inverse relationship between antral gastrin and somatostatin release is uncoupled under these conditions.