tbuckley/cabot-search huggingface dataset:
A lipoprotein characterizing obstructive jaundice. I. Method for quantitative separation and identification of lipoproteins in jaundiced subjects
Authors: D. Seidel, P. Alaupovic, R. H. Furman
Journal: Journal of Clinical Investigation (1969)

Three immunochemically and electrophoretically distinct lipoproteins, LP-A, LP-B, and LP-X,(1) were isolated from the low density lipoprotein fraction (1.006-1.063 g/ml) in plasma from patients with biliary obstruction by a separation procedure which combines ultracentrifugation, heparin precipitation, and ethanol fractionation. This method, here described, permits the quantitative determination of individual plasma lipoprotein families on the basis of their protein moieties, rather than on the basis of their lipid moieties or density. The chemical composition of the unique lipoprotein, LP-X, was similar to that of an abnormal lipoprotein, OLP, isolated by Russ et al. (29) and by Switzer (30). In obstructive jaundice plasma, the combined LP-X and LP-B accounted for 98% and the LP-A for only 2% of the total protein content of the LDL fraction. This study indicates that the plasma lipoprotein pattern in obstructive jaundice is characterized by (a) a decreased concentration of HDL, (b) an increased concentration of LDL, and (c) the presence in the LDL fraction of varying amounts of a specific lipoprotein, LP-X, immunochemically and chemically distinct from LP-A and LP-B. LP-X, with its characteristically high content of unesterified cholesterol and phospholipids, is primarily responsible for the unusual protein and lipid content of the LDL fraction. Screening tests in 61 patients with various forms of jaundice indicated that a characteristic immunoelectrophoretic precipitin are between plasma samples and purified antibodies to LP-X was observed only in patients with obstructive jaundice. This simple immunochemical test may represent a valuable new tool in the differential diagnosis of obstructive and nonobstructive jaundice.
Acquired ichthyosis and toxic epidermal necrolysis and mesenteric reticulum cell sarcoma and malabsorption.
Authors: A P Brooks, C I Harrington
Journal: BMJ (1977)

~~~~~~~~~~~~~; 12houlrs Ẽlectrocardiogram at diagnosis and 12 hours later showing disappearance of large U waves and appearance of normal T waves.24 mmol of magnesium sulphate intramuscularly over the next 24 hours.Then 115 mmol daily of effervescent potassium chloride was given orally for the next two days.Muscle power returned to normal within 12 hours, and it was then found that the patient had been eating about 1-8 kg of liquorice sweets per week.Three months after stopping liquorice she remained well, and all laboratory values were normal.
Film: A Beautiful Mind
Authors: A. David
Journal: BMJ (2002)

Aspergillus fumigatus secretes an 18-kDa nonglycosylated IgE-binding protein. This protein was previously shown to be a ribotoxin, like alpha-sarcin and mitogillin. A 686-bp long A. fumigatus cDNA encoding an 18-kDa ribotoxin was cloned and expressed in Escherichia coli as a fusion protein with six adjacent histidines (rAsp f I/a). rAsp f I/a was purified to homogeneity by Ni(2+)-chelate affinity chromatography and refolded. The recombinant protein was enzymatically active resulting in the cleavage of 28S rRNA within a universally conserved region. rAsp f I/a was cytotoxic for EBV immortalized or PHA stimulated human PBMC. Furthermore, rAsp f I/a was recognized by murine mAb made against an 18-kDa ribotoxin. IgE of individuals allergic to A. fumigatus bound to rAsp f I/a as shown by ELISA, dot blots, and Western blots. rAsp f I/a elicited positive immediate type I skin reactions in individuals allergic to A. fumigatus but not in healthy control individuals. The results show that rAsp f I/a has similar functional characteristics when compared to the native 18-kDa ribotoxin. rAsp f I/a expressed in E. coli can therefore be used as a standardized Ag/allergen for serologic and clinical diagnosis of A. fumigatus-associated diseases.
Platelet aggregation in Hyperapobetalipoproteinemia
Authors: M. Miller, W. Bell, S. Plano, J. Connors, S. Kennedy, P. Kwiterovich
Journal: American Journal of Hematology (1991)

Abstract Hyperapobetalipoproteinemia (HyperapoB) is a lipid disorder characterized by premature coronary disease, although the mechanisms have not been elucidated. Because abnormalities in platelet function may represent an enhanced susceptibility to coronary thrombosis, the aggregability of platelets was examined in hyperapoB subjects. Compared to controls, there were no significant differences in either platelet lipid composition or in aggregation to epinephrine, ADP, or collagen. In contrast to other dyslipidemias, platelet function does not appear to be abnormal in this well defined lipid disorder.
Long–term restoration of immunity against Epstein–Barr virus infection by adoptive transfer of gene–modified virus–specific T lymphocytes
Authors: Helen E. Heslop, Catherine Y.C. Ng, Congfen Li, Colton A. Smith, Susan K. Loftin, Robert A. Krance, Malcolm K. Brenner, Cliona M. Rooney
Journal: Nature Medicine (1996)
Genome sequencing of 161 Mycobacterium tuberculosis isolates from China identifies genes and intergenic regions associated with drug resistance
Authors: Hongtai Zhang, Dongfang Li, Lili Zhao, Joy Fleming, Nan Lin, Ting Wang, Zhangyi Liu, Chuanyou Li, Nicholas Galwey, Jiaoyu Deng, Ying Zhou, Yuanfang Zhu, Yunrong Gao, Tong Wang, Shihua Wang, Yufen Huang, Ming Wang, Qiu Zhong, Lin Zhou, Tao Chen, Jie Zhou, Ruifu Yang, Guofeng Zhu, Haiying Hang, Jia Zhang, Fabin Li, Kanglin Wan, Jun Wang, Xian-En Zhang, Lijun Bi
Journal: Nature Genetics (2013)
Evidence based prevention of acute injuries during physical exercise in a WHO safe community
Authors: T Timpka, K Lindqvist
Journal: British Journal of Sports Medicine (2001)

Objective —To evaluate a community based programme for evidence based prevention of injuries during physical exercise. Design —Quasi-experimental evaluation using an intervention population and a non-random control population. Participants —Study municipality (population 41 000) and control municipality (population 26 000) in Sweden. Main outcome measures —Morbidity rate for sports related injuries treated in the health care system; severity classification according to the abbreviated injury scale (AIS). Results —The total morbidity rate for sports related injuries in the study area decreased by 14% from 21 to 18 injuries per 1000 population years (odds ratio 0.87; 95% confidence interval (CI) 0.79 to 0.96). No tendency towards a decrease was observed in people over 40. The rate of moderately severe injury (AIS 2) decreased to almost half (odds ratio 0.58; 95% CI 0.50 to 0.68), whereas the rate of minor injuries (AIS 1) increased (odds ratio 1.22; 95% CI 1.06 to 1.40). The risk of severe injuries (AIS 3–6) remained constant. The rate of total sports injury in the control area did not change (odds ratio 0.93; 95% CI 0.81 to 1.07), and the trends in the study and control areas were not statistically significantly different. Conclusion —An evidence based prevention programme based on local safety rules and educational programmes can reduce the burden of injuries related to physical exercise in a community. Future studies need to look at adjusting the programme to benefit all age groups.
Asthma treatment: ‘magic bullets which seek their own targets’
Authors: F. Tarantini, I. Baiardini, G. Passalacqua, F. Braido, G. W. Canonica
Journal: Allergy (2007)

The most fascinating options of the new asthma treatments are probably represented by monoclonal antibodies. In fact, these molecules are virtually able to interact with whatever specific antigen. Anyway, it is mandatory to understand the limits of this group of molecules, in terms of both efficacy and safety. In this review, we have analyzed different ways of interfering along the course of the cascade of the allergic reaction, targeting different molecules (CD4, TNF‐α, IL‐4, IL‐5, IL‐10, IL‐12, endothelial adhesion molecules, IgE), showing the efficacy and the risks of each kind of treatment. In the end, we focused our attention on omalizumab, the monoclonal antibody targeting IgE. Although with some restrictions, represented by the high costs and the limitation of its use only to a specific subset of patients affected by allergic asthma, at present anti‐IgE appear to be the only ‘magic bullet’ for the treatment of allergic asthma. In fact, it proved to reduce exacerbations and symptom scores, and to improve quality of life, with a very good safety profile.
Feminine Behavior in Boys: Aspects of Its Outcome
Authors: PHIL S. LEBOVITZ
Journal: American Journal of Psychiatry (1972)

The author studied the outcome of 16 subjects who had exhibited feminine behavior as young boys. A structured interview, devised b culling from the literature those factors considered to be associated with gender identity disturbances, and a battery of psychological tests were administered. Six of the subjects showed markedly deviant gender identities; three were transsexuals, one a transvestite, and two homosexuals. There appeared to be two peaks for the age of onset of symptoms: before age six and after age ten. The data suggest that those with the earlier age of onset are more likely to develop severe gender identity disturbances.
IL-31 is associated with cutaneous lymphocyte antigen–positive skin homing T cells in patients with atopic dermatitis
Authors: Janine Bilsborough, Donald Y.M. Leung, Mark Maurer, Michael Howell, Mark Boguniewcz, Lena Yao, Harold Storey, Cosette LeCiel, Brandon Harder, Jane A. Gross
Journal: Journal of Allergy and Clinical Immunology (2006)
Unwanted Journals and the Environment
Authors: Daniel J. Highkin
Journal: Annals of Internal Medicine (1990)

Letters15 December 1990Unwanted Journals and the EnvironmentDaniel J. Highkin, MDDaniel J. Highkin, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-113-12-996_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: As McCally and Cassell (1) point out, we must all make lifestyle changes personally and professionally to avert global environmental catastrophe. I have recently attempted to prevent unwanted "throw-away" journals from coming into our office, and have encountered numerous structural roadblocks to this effort.These journals are a threat to our environment because they contribute to deforestation, global warming, hazardous waste, and the overfilling of landfills. They also increase the cost of medical care.I recently compiled a list of all nonrequested journals that are sent to the 20 internists in our multispecialty group, and asked each...Reference1. McCallyCassel MC. Medical responsibility and global environmental change. Ann Intern Med. 1990;113:467-73. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: 700 NE 87th Avenue Vancouver, WA 98664 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByThe tyranny of the throwawaysResponsibilities of medical journals to readers 15 December 1990Volume 113, Issue 12Page: 996-996 Issue Published: 15 December 1990 PDF DownloadLoading ...
Rapid and strong human CD8+ T cell responses to vaccination with peptide, IFA, and CpG oligodeoxynucleotide 7909
Authors: Daniel E. Speiser, Danielle Liénard, Nathalie Rufer, Verena Rubio-Godoy, Donata Rimoldi, Ferdy Lejeune, Arthur M. Krieg, Jean-Charles Cerottini, Pedro Romero
Journal: Journal of Clinical Investigation (2005)

The induction of potent CD8+ T cell responses by vaccines to fight microbes or tumors remains a major challenge, as many candidates for human vaccines have proved to be poorly immunogenic. Deoxycytidyl-deoxyguanosin oligodeoxynucleotides (CpG ODNs) trigger Toll-like receptor 9, resulting in dendritic cell maturation that can enhance immunogenicity of peptide-based vaccines in mice. We tested whether a synthetic ODN, CpG 7909, could improve human tumor antigen–specific CD8+ T cell responses. Eight HLA-A2+ melanoma patients received 4 monthly vaccinations of low-dose CpG 7909 mixed with melanoma antigen A (Melan-A; identical to MART-1) analog peptide and incomplete Freund's adjuvant. All patients exhibited rapid and strong antigen-specific T cell responses: the frequency of Melan-A–specific T cells reached over 3% of circulating CD8+ T cells. This was one order of magnitude higher than the frequency seen in 8 control patients treated similarly but without CpG and 1–3 orders of magnitude higher than that seen in previous studies with synthetic vaccines. The enhanced T cell populations consisted primarily of effector memory cells, which in part secreted IFN-γ and expressed granzyme B and perforin ex vivo. In vitro, T cell clones recognized and killed melanoma cells in an antigen-specific manner. Thus, CpG 7909 is an efficient vaccine adjuvant that promotes strong antigen-specific CD8+ T cell responses in humans.
Maturation of Dendritic Cells Is Accompanied by Rapid Transcriptional Silencing of Class II Transactivator (Ciita) Expression
Authors: Salomé Landmann, Annick Mühlethaler-Mottet, Luca Bernasconi, Tobias Suter, Jean-Marc Waldburger, Krzysztof Masternak, Jean-François Arrighi, Conrad Hauser, Adriano Fontana, Walter Reith
Journal: The Journal of Experimental Medicine (2001)

Cell surface expression of major histocompatibility complex class II (MHCII) molecules is increased during the maturation of dendritic cells (DCs). This enhances their ability to present antigen and activate naive CD4+ T cells. In contrast to increased cell surface MHCII expression, de novo biosynthesis of MHCII mRNA is turned off during DC maturation. We show here that this is due to a remarkably rapid reduction in the synthesis of class II transactivator (CIITA) mRNA and protein. This reduction in CIITA expression occurs in human monocyte-derived DCs and mouse bone marrow–derived DCs, and is triggered by a variety of different maturation stimuli, including lipopolysaccharide, tumor necrosis factor α, CD40 ligand, interferon α, and infection with Salmonella typhimurium or Sendai virus. It is also observed in vivo in splenic DCs in acute myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalitis. The arrest in CIITA expression is the result of a transcriptional inactivation of the MHC2TA gene. This is mediated by a global repression mechanism implicating histone deacetylation over a large domain spanning the entire MHC2TA regulatory region.
The Early Detection and Treatment of Spinal Caries
Authors: E. Owen
Journal: BMJ (1882)

position; the mechanical bearings being shown by the arrows in the figure (9).2, It favours thoracic respiration (a very important point in severe Ad ' t, cases).3. It can be accurately adjusted and readjusted bythe surgeon himself.No oJ4.t a ,a ei 'k other apparatus that has yet been made generally known possesses these qualities, (d; i. and all others have disadvantages which .A.i;1 J '. i'} in.do not belong to this one.v .1.;tl With regard to the adjustability of this _i e splint, it may be observed that, although the spine may be fixed in a good position upon one day, it does not neces-A;( sarily follow that it will be desirable to ;SJ 'J *-'; v- ; --attempt to maintain it in that position Ho until the disease has ceased, and the *Eso« b; .:boneshave become ankylosed.On the ..-OL'j ;ji contrary, resolution is almost sure to be roNU.C, en I~l ;accompanied by a slight and gradual
The African enigma: the parasite's perspective
Authors: J G FOX
Journal: Gut (2001)

Editor,—We would like to thank Professor MacDonald for his interest in our work, and for his recent comment on our paper ((2001) Gut 48:10–11.[OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4]). However, we must take issue with a number of his comments. With respect to the clinical implications of our study,1 we have not advocated treatment of Helicobacter pylori infected patients with intestinal parasites for the purpose of inducing a shift in the Th1/Th2 immune response, a possibility raised by Professor MacDonald. As Professor MacDonald is well aware, this approach has been suggested for a number of chronic diseases such as inflammatory bowel disease. However, in the case of chronic H pylori infection, antibiotic therapy has proved effective and in our opinion is a much safer and more palatable approach for most patients. We appreciate Professor MacDonald's careful analysis of our histopathological results. However, we are confused regarding his comments of "negative … [1]: {openurl}?query=rft.jtitle%253DNature%2Bmedicine%26rft.stitle%253DNat%2BMed%26rft.aulast%253DFox%26rft.auinit1%253DJ.%2BG.%26rft.volume%253D6%26rft.issue%253D5%26rft.spage%253D536%26rft.epage%253D542%26rft.atitle%253DConcurrent%2Benteric%2Bhelminth%2Binfection%2Bmodulates%2Binflammation%2Band%2Bgastric%2Bimmune%2Bresponses%2Band%2Breduces%2Bhelicobacter-induced%2Bgastric%2Batrophy.%26rft_id%253Dinfo%253Adoi%252F10.1038%252F75015%26rft_id%253Dinfo%253Apmid%252F10802709%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1038/75015&link_type=DOI [3]: /lookup/external-ref?access_num=10802709&link_type=MED&atom=%2Fgutjnl%2F49%2F1%2F156.2.atom [4]: /lookup/external-ref?access_num=000086796200037&link_type=ISI
Population Trends From 2000-2011 in Nuclear Myocardial Perfusion Imaging Use
Authors: Edward J. McNulty, Yun-Yi Hung, Lucy M. Almers, Alan S. Go, Robert W. Yeh
Journal: JAMA (2014)

Nuclear myocardial perfusion imaging (MPI) accounted for much of the rapid growth in cardiac imaging that occurred from the 1990s through the middle 2000s. 1,2Factors potentially discouraging use (including publication of appropriate use criteria) have since emerged, 3 and recent data reveal modest declines in MPI use in the Medicare fee-for-service population. 4 We investigated temporal trends in MPI use within a large, community-based population that included persons younger than 65 years and explored whether increasing use of other noninvasive imaging modalities potentially offset declining MPI use.
Hairy Cell Leukemia: Diagnosis and Management
Authors: H. M. Golomb, J. Vardiman
Journal: CA A Cancer Journal for Clinicians (1978)

available for confirming the diagnosis.Therapeutic options may be critically im portant during the course of the illness since splenectomy may be uniquely bene ficial.The failure to make the correct diagnosis can lead to inappropriately ag gressive chemotherapy and result in un necessary morbidity and mortality. Clinical FeaturesHairy cell leukemia is primarily a disease of middle-aged men.The age of the pa tients reported has ranged from the 20's to the 80's, but the average age is in the low 50's.The male:female ratio is approxi mately 4:1.348,10Abdominal fullness or discomfort, associated with splenomegaly, is the only specific complaint given by about one fourth of the patients.Nonspecific com plaints, such as fatigue, weight loss, and weakness are reported by another fourth, and an equal number have ease of bruising or infections associated with thrombo cytopenia or leukopenia.Patients who are asymptomatic and who have an abnormal blood count or splenomegaly, detected during a routine check-up or during eval uation for an unrelated disease, account for the remainder of the cases of HCL (Table 1).Splenomegaly is frequently massive and may be the most prominent physical
HIV Infection in Parturients
Authors: B. Anthony Armson
Journal: JAMA (1988)

To the Editor.  —Recent studies of childbearing women in New York City indicate seroprevalence rates of human immunodeficiency virus (HIV) antibody (Ab) between 1.64% and 2.35%.1,2These results provide the first comprehensive look at HIV infection in parturients from a population with a high incidence of acquired immunodeficiency syndrome and raise important questions regarding counseling and HIV-Ab testing programs for pregnant women.3  We recently completed a study, approved by the institutional review board, to determine the seroprevalence of HIV-Ab in obstetric patients delivered at an inner-city, tertiary-care hospital in Philadelphia. The Hospital of the University of Pennsylvania is a 700-bed facility that provides medical care for a large minority population. There are 3500 deliveries a year at the hospital, approximately 10% of which are to women who are at risk of HIV infection. Current policy provides for voluntary testing for obstetric patients who identify themselves as being at
Inhalation of diesel engine exhaust affects spermatogenesis in growing male rats.
Authors: N Watanabe, Y Oonuki
Journal: Environmental Health Perspectives (1999)

We conducted experiments to determine whether diesel engine exhaust affects reproductive endocrine function in growing rats. The rats were assigned to three groups: a group exposed to total diesel engine exhaust containing 5.63 mg/m3 particulate matter, 4.10 ppm nitrogen dioxide, and 8.10 ppm nitrogen oxide; a group exposed to filtered exhaust without particulate matter; and a group exposed to clean air. Dosing experiments were performed for 3 months beginning at birth (6 hr/day for 5 days/week). Serum levels of testosterone and estradiol were significantly higher in animals exposed to total diesel exhaust and filtered exhaust (p < 0.05 for each group) as compared to the controls. Follicle-stimulating hormone was significantly decreased in the two groups exposed to diesel exhaust as compared to the control group (p < 0.05). Luteinizing hormone was significantly decreased in the total exhaust-exposed group as compared to the control and filtered groups (p < 0.05). Although testis weight did not show any significant difference among the groups, sperm production and activity of testicular hyaluronidase were significantly reduced in both exhaust-exposed groups as compared to the control group. Histological examination showed decreased numbers of step 18 and 19 spermatids in stage VI, VII, and VIII tubules in the testes of both diesel exhaust-exposed groups. This study suggests that diesel exhaust stimulates hormonal secretion of the adrenal cortex, depresses gonadotropin-releasing-hormone, and inhibits spermatogenesis in rats. Because these effects were not inhibited by filtration, the gaseous phase of the exhaust appears to be more responsible than particulate matter for disrupting the endocrine system.
The c-KIT mutation causing human mastocytosis is resistant to STI571 and other KIT kinase inhibitors; kinases with enzymatic site mutations show different inhibitor sensitivity profiles than wild-type kinases and those with regulatory-type mutations
Authors: Yongsheng Ma, Shan Zeng, Dean D. Metcalfe, Cem Akin, Sasa Dimitrijevic, Joseph H. Butterfield, Gerald McMahon, B. Jack Longley
Journal: Blood (2002)