Postischemic Myocardial "Stunning": A Clinically Relevant Phenomenon
Authors: BHARAT PATEL
Journal: Annals of Internal Medicine (1988)

Editorials1 April 1988Postischemic Myocardial "Stunning": A Clinically Relevant PhenomenonBHARAT PATEL, M.D., ROBERT A. KLONER, M.D., Ph.D., KARIN PRZYKLENK, Ph.D., EUGENE BRAUNWALD, M.D.BHARAT PATEL, M.D., ROBERT A. KLONER, M.D., Ph.D., KARIN PRZYKLENK, Ph.D., EUGENE BRAUNWALD, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-108-4-626 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCoronary artery reperfusion by means of thrombolytic therapy is rapidly emerging as a fundamental strategy in the management of patients with acute myocardial infarction. Although successful recanalization can be achieved in most patients receiving timely interventional therapy for evolving myocardial infarction, previous experimental studies have shown that reperfusion, despite limiting infarct size, does not lead to immediate full recovery in regional myocardial function. Instead, the return of contractility in tissue salvaged by reflow is delayed for hours, days, or weeks (1-5)—a phenomenon termed "stunned myocardium" (6).Myocardial stunning has been extensively studied in several experimental models of both brief and...References1. HEYNDRICKXMILLARDMCRITCHIEMAROKOVATNER GRRPS. Regional myocardial functional and electrophysiological alterations after brief coronary artery occlusion in conscious dogs. J Clin Invest. 1975;56:978-85. CrossrefMedlineGoogle Scholar2. HEYNDRICKXBAIGNELLENSLEUSENFISHBEINVATNER GHPIMS. Depression of regional blood flow and wall thickening after brief coronary occlusions. Am J Physiol. 1978;234:H653-9. MedlineGoogle Scholar3. ELLISHENSCHKESANDORWYNNEBRAUNWALDKLONER SCTJER. Time course of functional and biochemical recovery of myocardium salvaged by reperfusion. J Am Coll Cardiol. 1983;1:1047-55. CrossrefMedlineGoogle Scholar4. BUSHBUJASAMOWITZ LLW. 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Author, Article, and Disclosure InformationAffiliations: Wayne State University and Harper Hospital Detroit, Michigan Brigham and Women's Hospital and Harvard Medical School Boston, Massachusetts PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByMyocardial stunning and hibernation revisitedStunned and Hibernating Myocardium: Where Are We Nearly 4 Decades Later?The Oxygen Paradox, the French Paradox, and age-related diseasesPathobiology of Ischemic Heart Disease: Past, Present and FuturePathophysiology of myocardial infarctionFailure is an option: learning from unsuccessful proof-of-concept trialsPathophysiology and Clinical Recognition of Heart FailureSevere stunned myocardium after lightning strikeMechanisms leading to reversible mechanical dysfunction in severe CAD: alternatives to myocardial stunningComputed tomography assessment of myocardial perfusion, viability, and functionECG changes after CABG: the role of the surgical 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