tbuckley/cabot-search huggingface dataset:
Hyperhomocysteinemia and Macroangiopathy in Type 2 Diabetes
Authors: N. Norman Chan, Tricia M.M. Tan, Steven J. Hurel
Journal: Diabetes Care (2001)

Elevated homocysteine is widely regarded as an independent risk factor for macrovascular disease, particularly in patients with type 2 diabetes (1). The increased prevalence of macroangiopathy in type 2 diabetes is further demonstrated by Buysschaert et al. (2). The authors found a significant increase in the prevalence of macroangiopathy in type 2 diabetic patients with hyperhomocysteinemia. Their data, however, should not be overinterpreted because the etiological role of homocysteine in atherosclerosis in the presence of macroangiopathy is far from clear (3).

First, the metabolism of homocysteine is altered for a period of several days following acute …
A Correction of Dr. Charles Denison's Article: " The Antitoxic Treatment of Tuberculosis."
Authors: Edwin Klebs
Journal: JAMA (1898)

Chicago, Feb. 14, 1898. <h3>To the Editor:</h3> —Dr. Charles Denison enumerates in the above mentioned article the different therapeutic products obtained from cultures of tubercle bacilli: the tuberculin Koch, the tuberculocidin and antiphthisin (Klebs). As No. 4 he gives " tuberculinum purificatum, which name Dr. Karl v. Ruck of Asheville has given to his manufacture of practically the same preparation." In a footnote the manner of preparation of the last is given, absolutely identical with the method published by me in 1894 for the preparation of tuberculocidin. As Dr. von Ruck, so far as I know, has never published the formula of his "tuberculinum purificatum," I can not say if Dr. Denison is in error or if Dr. von Ruck has brought on the market a preparation the same as tuberculocidin, simply using another name. Probably the first suggestion is the correct one, but the profession should be enlightened on this
'Pacemaker' studied for impotence
Authors: Tom Hager
Journal: JAMA (1983)

By some estimates, as many as 10 million men in the United States may be experiencing some form of impotence. At the recent American Urological Association meeting in Las Vegas, Tom F. Lue, MD, and co-workers Richard A. Schmidt, MD, and Emil A. Tanagho, MD, at the University of California, San Francisco, School of Medicine, reported that they have developed a system for studying the physiology of erections under controlled conditions in lower primates. The key was the discovery, after a six-month search, of several bundles of "basically parasympathetic" nerves posterolateral to the prostate of monkeys. These bundles, the researchers say, can trigger erections when electrically stimulated. By surgically implanting small electrodes that are activated via radio signals, Lue's group is able to induce and maintain erections in the animals for periods up to several hours. "People have said that the erect penis is a closed system, but that's not true,"
Identification of a functional NF-kappa B binding site in the murine T cell receptor beta 2 locus.
Authors: C Jamieson, F Mauxion, R Sen
Journal: The Journal of Experimental Medicine (1989)

We have identified a sequence in the TCR beta 2 locus that is homologous to the kappa B site in the Ig kappa light chain enhancer. This element, TCR beta-B, is located in the vicinity of previously identified T cell-specific DNase1 hypersensitive sites. Transfection analysis shows that a 60-bp fragment encompassing this site is preferentially active in T cells stimulated with phorbol esters or the HTLV-1 tax gene product compared with a B cell line that constitutively expresses NF-kappa B. Our results provide the first evidence for transcriptional regulatory sequences residing within the J beta 2-C beta 2 intron and suggest the possible involvement of these sequences in modulation of TCR beta gene expression upon cellular activation.
Tetralogy of Fallot
Authors: MASAO IKEDA, KOSHICHIRO HIROSAWA
Journal: Circulation (1968)

Although the natural course of tetralogy of Fallot is not yet clear, the life-span seems to be short except in rare cases of mild pulmonary stenosis or in cases associated with a sizeable systemic-pulmonary anastomosis. Two hundred and nine patients with tetralogy of Fallot underwent operation in the Department of Thoracic Surgery, University of Tokyo. The Blalock-Taussig operation was performed in 137 patients between 1951 and 1965. Total surgical mortality was 9% (3.5% in recent years). Analysis of 124 patients surviving an average of 5.5 years postoperatively showed that 45% of patients were still doing well, 4% had fair results, 12% exhibited no improvement, 15% required a second operation (either a second anastomosis or total correction), and 10% died of cerebral embolism, cardiac failure, or other causes (there are no details on the remaining 5% who survived). Total correction was carried out in 72 patients between 1955 and 1965. In nine of these cases, a shunt procedure had been performed previously. Total surgical mortality was 50% (19% in recent years). Surgical mortality of total correction from the world literature has fallen impressively due to improvement of surgical technique and selection of patients, but it is still higher than that of the Blalock-Taussig operation. Clinical improvement of 36 surviving patients, however, was much greater and more complete after total correction than after the Blalock-Taussig operation, although final evaluation of total correction must await long-term follow-up studies. Functional capacity and exercise tolerance have improved in the great majority of patients after total correction. Arterial oxygen saturation, hemoglobin concentration, and the hematocrit value have returned to normal values in almost all cases.
Human skin aryl hydrocarbon hydroxylase
Authors: M.J. FINNEN, C.M. LAWRENCE, SAM SHUSTER
Journal: British Journal of Dermatology (1984)

Journal Article Human skin aryl hydrocarbon hydroxylase Get access M.J. FINNEN, M.J. FINNEN Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne NEI 4LP Dr M.J. Finnen, Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne NEI4LP. Search for other works by this author on: Oxford Academic Google Scholar C.M. LAWRENCE, C.M. LAWRENCE Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne NEI 4LP Search for other works by this author on: Oxford Academic Google Scholar SAM SHUSTER SAM SHUSTER Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne NEI 4LP Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 110, Issue 3, 1 March 1984, Pages 339–342, https://doi.org/10.1111/j.1365-2133.1984.tb04640.x Published: 01 March 1984 Article history Accepted: 11 August 1983 Published: 01 March 1984
The first year of life: Jaundice in the newborn.
Authors: H. B. Valman
Journal: BMJ (1989)

From the revised edition of"The First Year ofLife, " to be published next week cells Jaundice is a yellow colour of the skin caused by high concentrations of bilirubin.Very severe jaundice may damage the cells of the basal ganglia and brain stem.This damage is produced by the fat soluble unconjugated bilirubin.If jaundice is severe high bilirubin concentrations may result in deafness, cerebral palsy, or death.Neonatal jaundice is due to an increased bilirubin load with a transient inefficiency of hepatic excretion resulting from decreased activity of glucuronyl transferase in the liver.There are additional factors.Some of the conjugated bilirubin excreted in the bile is normally deconjugated in the small intestine and reabsorption is enhanced by the slower gut transit in the starved newborn.Bilirubin is absorbed from meconium and there is no intestinal flora to degrade bilirubin to urobilinogen.Common causes of jaundice in the newborn Onset Common causes of jaundice include hepatic immaturity, red cell incompatibility, infection, and breast feeding.
Effects of verapamil on ischemia-induced changes in extracellular K+, pH, and local activation in the pig.
Authors: W F Fleet, T A Johnson, C A Graebner, C L Engle, L S Gettes
Journal: Circulation (1986)

In experimental animals, the calcium channel-blocking agents lessen the arrhythmogenic, ionic, metabolic, and electrical changes that occur during acute myocardial ischemia. To date, these effects have been studied separately, and the effects of these agents on local activation have not been correlated with ionic or metabolic effects. In open-chest, anesthetized swine, we used bipolar and ion-selective plunge electrodes to simultaneously measure ischemia-induced changes in left ventricular local activation, extracellular K+ ([K+]e), and extracellular pH (pHe). The effects of verapamil (0.2 mg/kg) on these variables were studied during a series of 10 min occlusions of the left anterior descending coronary artery. Compared with control occlusions, verapamil (1) slowed the rise in [K+]e at the center of the ischemic zone and at its lateral margin and decreased the peak [K+]e by 0.9 mM at the center (p less than .05) and by 0.1 mM at the margin (p = .10); (2) slowed the development of acidosis and decreased the peak level of acidosis beyond that expected solely as a result of serial occlusions by 0.19 pH units at the center (p less than .05) and by 0.07 pH units at the margin (p = .10); and (3) slowed the development of local activation delay and often prevented the local activation block that was observed during control occlusions. Effects on local activation became less marked at [K+]e levels greater than 9.0 mM, and the effects of verapamil on local activation were not explained solely by its effects on the local rise in [K+]e or fall in pHe. A possible mechanism for this additional effect on local activation is suggested by preliminary results showing a diminution by verapamil of ionic inhomogeneity.
Synthetic Tumor-Associated Glycopeptide Antigens
Authors: Horst Kunz, Peter Wernig, Marita Schilling, Joachim Marz, Carlo Unverzagt, Stefan Birnbach, Uwe Lang, Herbert Waldmann
Journal: Environmental Health Perspectives (1990)

Glycopeptides with TN antigen (GalNAc)Ser/Thr and T-antigen structures (beta Gall-3GalNAc)Ser/Thr, described as tumor-associated antigens, were synthesized and coupled to bovine serum albumin. Alternatively, synthetic methods for the construction of beta-anomeric analogues of the TN and T-antigen glycopeptides were developed, aiming at antigenic structures having a varied stereochemistry of the linkage between the carbohydrate and the peptide moiety. As a further type of potential tumor-associated antigen, fucosyl-chitobiose asparagine glycopeptides were synthesized, deprotected, and coupled to bovine serum albumin. The chemical methods developed now make the complex sensitive glycoprotein partial structures accessible in analytically pure form and in preparative amounts.
APPENDICITIS: WHAT IT IS AND WHAT IT IS NOT—FROM A SURGICAL STANDPOINT.Read before the Section on Surgery and Anatomy at the Forty-fourth Annual Meeting of the American Medical Association.
Authors: JOSEPH HOFFMAN
Journal: JAMA (1893)

Among many with the fear of surgery before their eyes, there is a widespread and possibly a growing opinion that the advanced surgeon of to-day rushes upon every so-called case of appendicitis knife in hand, something after the manner in which our English friends fearfully dread the wild onslaught of the murderous Comanche in Chicago. To the surgeon holding in his mind the dangers and complexities of all serious abdominal work, most of all that in which the integrity of the vital organs is involved, the eagerness with which this operation is supposed to be sought is amusing. With those to whom the abdomen is as yet a fairyland of surgery, where reputation may be speedily got, and mistakes hastily veiled in the coroner's office by death from heart failure and exhaustion, the fair field is enticing. But woe to the untrained explorer who anchors his tray beside the siren,
Measurement of transstenotic pressure gradient during percutaneous transluminal coronary angioplasty.
Authors: H V Anderson, G S Roubin, P P Leimgruber, W R Cox, J S Douglas, S B King, A R Gruentzig
Journal: Circulation (1986)

Obstruction to blood flow is accompanied by a pressure gradient across the obstructed site. In certain clinical settings, magnitude of pressure gradient has been used to judge severity of obstruction, and gradient reduction to judge success of an interventional procedure. In percutaneous transluminal coronary angioplasty (PTCA) the relationships between transstenotic pressure gradient, diameter stenosis, and lesion length are imprecisely known. We therefore examined 4263 sets of measurements in patients who underwent PTCA on single, discrete coronary arterial lesions. Multivariate regression analysis demonstrated that pressure gradient was artifactually elevated by about 12 mm Hg at low values of diameter stenosis but increased by the 4th power of stenosis as expected from fluid dynamics models. Pressure gradient was dampened and relatively constant at values of diameter stenosis of 60% or higher, probably because of total or near-total occlusion of the artery. Lesion length was not found to influence pressure gradient. Reductions in diameter stenosis (delta D) and pressure gradient (delta G) were related nonlinearly, with delta D proportional to the square root of delta G, suggesting that a reduction in gradient is directly proportional to an increase in cross-sectional area of the stenosis. The predictive value of final post-PTCA pressure gradients was found: a final gradient of 15 mm Hg or less predicted a final post-PTCA diameter stenosis of 30% or less, with 75% sensitivity and 29% specificity (p less than .01). The results of this study suggest that (1) pressure gradient as currently measured during PTCA is related to diameter stenosis but not to lesion length (2) reductions in pressure gradient and diameter stenosis are nonlinearly related.(ABSTRACT TRUNCATED AT 250 WORDS)
The Teaching of Medical Jurisprudence.
Authors: Henry Leffmann
Journal: JAMA (1906)

Philadelphia, Sept. 8, 1906. <h3>To the Editor:</h3> —A valuable service to the cause of good medical education was done by your editorial August 25 concerning the extent of teaching of medical jurisprudence In American medical schools. During a considerable part of my active professional life, I was chemist to the coroner and district attorney of this city, and had, therefore, much opportunity to see the necessity of instruction in the determination of causes of death. It seemed sad to see the vast amount of valuable material that was allowed to go to waste in connection with numerous and varied forms of violent death. In this city the coroner appoints one or more physicians, who make the necessary postmortems and report to the office. As is known throughout the nation. Philadelphia has been for many years in the grip of a political ring, which has no superior in the world for
New sunscreens confer improved protection for photosensitive patients in the blue light region
Authors: H. Moseley, H. Cameron, T. MacLEOD, C. Clark, R. Dawe, J. Ferguson
Journal: British Journal of Dermatology (2001)

Background Some patients with photosensitivity disorders are sensitive to visible radiation. As current commercial sunscreens do not significantly absorb in this region, there is a lack of effective topical photoprotection. To meet this need a new range of sunscreens has been developed incorporating zinc oxide and pigmentary grade titanium dioxide as active ingredients. Objectives To determine the effectiveness of the new sunscreens in providing protection for patients with visible radiation photosensitivity. Methods In the first part of this study, an in vitro transmission spectrum was obtained. The properties of the new sunscreens, as well as a range of commercial agents, were compared, and a new parameter, photosensitivity protection factor (PPF), was developed. This was used to predict the likely degree of protection the various sunscreens would provide for patients with photosensitivity extending into the visible region. In the second in vivo part of the study, patients with known visible (blue) light photosensitivity were tested using light at 430 ± 30 nm and the protection factor (PF) at this wavelength was determined. Results Mean ± SD PPFs for the new sunscreens were between 5·4 ± 0·3 and 9·6 ± 0·3, compared with 4·1 ± 0·1 for Sun E45 (sun protection factor, SPF 25) and 4·2 ± 0·1 for RoC Total (SPF 25). The derived in vivo PF for Sun E45 ranged between 1 and 4 (median 2). For the new sunscreens the range was 3 to > 10 (median 8). Conclusions This study demonstrates that the new sunscreens do provide protection for patients with sensitivity to visible light (blue light region).
Association of heparin‐induced skin lesions, intracutaneous tests, and heparin‐induced IgG
Authors: J Harenberg, G Huhle, L Wang, U Hoffmann, Ch Bayerl, M Kerowgan
Journal: Allergy (1999)

Background: Cutaneous heparin‐induced allergic reactions to subcutaneous heparin may begin 2–5 days after administration. The relation of the delayed‐type hypersensitivity and a systemic immunologic response is controversial. The present investigation aimed to analyze the occurrence of thromboembolic complication, pathologic heparin‐induced platelet activation (HIPA), and the presence of circulating heparin‐induced IgG in patients with heparin‐induced skin reactions. Methods: Intracutaneous tests, HIPA assay, and heparin‐heparin IgG antibodies were performed in nine patients with heparin‐induced skin lesions. Results: Six of eight patients showed positive intracutaneous tests to heparin and to four low‐molecular‐weight heparins. Three of six heparin‐positive patients presented hypersensitivity to a heparinoid, too. Two of three patients had a positive HIPA test and elevated heparin‐induced IgG antibodies. Both patients developed complications presenting as heparin‐induced skin necrosis or arterial thrombosis. Two of nine patients were treated with danaparoid, 4/9 patients received r‐hirudin, and 1/9 received oral coumarin. In 2/9 patients, anticoagulant therapy was stopped, but these patients will receive r‐hirudin if indicated. Conclusions: On the basis of the coincidence of local and systemic hyperreactivity to heparin and danaparoid, patients with heparin‐induced skin lesions should receive r‐hirudin, a nonheparin compound, for anticoagulant treatment.
F-Box and Leucine-Rich Repeat Protein 22 Is a Cardiac-Enriched F-Box Protein That Regulates Sarcomeric Protein Turnover and Is Essential for Maintenance of Contractile Function In Vivo
Authors: Sebastian Spaich, Rainer D. Will, Steffen Just, Saskia Spaich, Christian Kuhn, Derk Frank, Ina M. Berger, Stefan Wiemann, Bernhard Korn, Manfred Koegl, Johannes Backs, Hugo A. Katus, Wolfgang Rottbauer, Norbert Frey
Journal: Circulation Research (2012)

Rationale: The emerging role of the ubiquitin–proteasome system in cardiomyocyte function and homeostasis implies the necessity of tight regulation of protein degradation. However, little is known about cardiac components of this machinery. Objective: We sought to determine whether molecules exist that control turnover of cardiac-specific proteins. Methods and Results: Using a bioinformatic approach to identify novel cardiac-enriched sarcomere proteins, we identified F-box and leucine-rich repeat protein 22 (Fbxl22). Tissue-specific expression was confirmed by multiple tissue Northern and Western Blot analyses as well as quantitative reverse-transcriptase polymerase chain reaction on a human cDNA library. Immunocolocalization experiments in neonatal and adult rat ventricular cardiomyocytes as well as murine heart tissue located Fbxl22 to the sarcomeric z-disc. To detect cardiac protein interaction partners, we performed a yeast 2-hybrid screen using Fbxl22 as bait. Coimmunoprecipitation confirmed the identified interactions of Fbxl22 with S-phase kinase-associated protein 1 and Cullin1, 2 critical components of SCF (Skp1/Cul1/F-box) E3- ligases. Moreover, we identified several potential substrates, including the z-disc proteins α-actinin and filamin C. Consistently, in vitro overexpression of Fbxl22-mediated degradation of both substrates in a dose-dependent fashion, whereas proteasome inhibition with MG-132 markedly attenuated degradation of both α-actinin and filamin C. Finally, targeted knockdown of Fbxl22 in rat cardiomyocytes as well as zebrafish embryos results in the accumulation of α-actinin associated with severely impaired contractile function and cardiomyopathy in vivo. Conclusions: These findings reveal the previously uncharacterized cardiac-specific F-box protein Fbxl22 as a component of a novel cardiac E3 ligase. Fbxl22 promotes the proteasome-dependent degradation of key sarcomeric proteins, such as α-actinin and filamin C, and is essential for maintenance of normal contractile function in vivo.
Diagnosis of viable myocardium using velocity information of doppler myocardial imaging: Comparison with positive emission tomography
Authors: Jae-Kwan Song, Hyun Suk Yang, Soo-Jin Kang, Jong-Min Song, Duk-Hyun Kang, Cheol Whan Lee, Myeong-Ki Hong, Jae-Joong Kim, Dae Hyuk Moon, Seong-Wook Park, Seung-Jung Park
Journal: Journal of the American College of Cardiology (2003)
Dermographism: reduction in weal size by chlorpheniramine and hydroxyzine
Authors: CYNTHIA N.A.M ATTHEWS, JOHN D. KIRBY, JEAN JAMES, ROBERT P. WARIN
Journal: British Journal of Dermatology (1973)

Journal Article Dermographism: reduction in weal size by chlorpheniramine and hydroxyzine Get access CYNTHIA N.A.M ATTHEWS, CYNTHIA N.A.M ATTHEWS Bristol General Hospital, Bristol Search for other works by this author on: Oxford Academic Google Scholar JOHN D. KIRBY, JOHN D. KIRBY Bristol General Hospital, Bristol Search for other works by this author on: Oxford Academic Google Scholar JEAN JAMES, JEAN JAMES Bristol General Hospital, Bristol Search for other works by this author on: Oxford Academic Google Scholar ROBERT P. WARIN ROBERT P. WARIN Bristol General Hospital, Bristol Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 88, Issue 3, 1 March 1973, Pages 279–282, https://doi.org/10.1111/j.1365-2133.1973.tb07548.x Published: 01 March 1973 Article history Accepted: 21 August 1972 Published: 01 March 1973