Serum Sickness
Authors: JOHN H. VAUGHAN
Journal: Annals of Internal Medicine (1967)

Case Studies1 September 1967Serum SicknessEvidence in Man of Antigen-Antibody Complexes and Free Light Chains in the Circulation During the Acute ReactionJOHN H. VAUGHAN, M.D., F.A.C.P., EUGENE V. BARNETT, M.D., PETER J. LEADLEY, M.D.JOHN H. VAUGHAN, M.D., F.A.C.P.Search for more papers by this author, EUGENE V. BARNETT, M.D.Search for more papers by this author, PETER J. LEADLEY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-3-596 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDecline in the use of animal serums for therapy of human infections has meant that serum sickness has become a much less common illness than it was in the early part of this century. Nonetheless, serum sickness continues to attract investigational interest because it represents a well-defined model of allergic disease to which an ever-expanding battery of immunological tools can be applied. The case of serum sickness to be reported followed therapy for rabies. Advantage was taken of its occurrence to make several interesting immunological observations.Experimental serum sickness has been related by Dixon (1) to the presence of antigen-antibody...References1. DIXON FJ: Role of antigen-antibody complexes in disease. Harvey Lect. 58: 21, 1963. MedlineGoogle Scholar2. BERGGARD I: On a γ-globulin of low molecular weight in normal human plasma and urine. Clin. Chim. Acta 6: 545, 1961. CrossrefGoogle Scholar3. STEVENSON GT: Further studies of the gamma-related proteins of normal urine. J. Clin. Invest. 41: 1190, 1962. CrossrefMedlineGoogle Scholar4. GORDONEISENVAUGHAN DAAZJH: Studies on urinary gamma-globulins in patients with rheumatoid arthritis. Arthritis Rheum. 9: 575, 1966. CrossrefGoogle Scholar5. : WHO Technical Report Series No. 201, 4th Report, Geneva, 1960. Google Scholar6. DIXON FJ: Experimental serum sickness, in Immunological Diseases, edited by SAMTER and associates. Little, Brown and Co., Boston, 1965, p. 164. Google Scholar7. WASSERMANLEVINE EL: Quantitative microcomplement fixation and its use in the study of antigenic structure by specific antigen-antibody inhibition. J. Immun. 87: 290, 1961. MedlineGoogle Scholar8. BARNETT EV: Quantitation of immunoglobulins and L-chains by complement fixation tests (abstract). Clin. Res. 15: 107, 1966. Google Scholar9. PORATHFLODIN JP: in Protides of the Biological Fluids, edited by PEETERS, H. Proceedings of the 10th Colloquium, Bruges, 1962. Elsevier Publishing Co., Amsterdam, 1963, p. 294. Google Scholar10. BIRO CE: La determinación de la euglobulina sérica y su utilidad en el diagnóstico de las enfermedades infecciosas. Arch. Inst. Cardiol. Mex. 34: 328, 1964. MedlineGoogle Scholar11. STRUTHERS EB: Kala-azar: criterion of cure. China Med. J. 38: 207, 1924. Google Scholar12. MÜLLER-EBERHARDNILSSONARONSSON HJUT: Isolation and characterization of two β1-glycoproteins of human serum. J. Exp. Med. 111: 201, 1960. CrossrefMedlineGoogle Scholar13. BARNETTSTONESWISHERVAUGHAN EVGSNJH: Serum sickness and plasmacytosis. A clinical, immunologic and hematologic analysis. Amer. J. Med. 35: 113, 1963. CrossrefMedlineGoogle Scholar14. EPSTEINTAN WVM: Increase of L-chain proteins in the sera of patients with systemic lupus erythematosus and the synovial fluids of patients with peripheral rheumatoid arthritis. Arthritis Rheum. 9: 713, 1966. CrossrefMedlineGoogle Scholar15. PIRQUETSCHICK CFB: Die Serum Krankheit. Franz Denticke, Liepzig and Wien, 1905. English edition, The Williams & Wilkins Co., Baltimore, 1951. Google Scholar16. KOJIS FG: Serum sickness and anaphylaxis. Amer. J. Dis. Child. 64: 93, 313, 1942. CrossrefGoogle Scholar17. RATNER B: Allergy, anaphylaxis and immunotherapy, in Serum Sickness. The Williams & Wilkins Co., Baltimore, 1943, p. 412. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester, New YorkFrom the Department of Medicine, University of Rochester School of Medicine and Dentistry, and the Strong Memorial and Rochester General Hospitals, Rochester, N. Y.This study was supported by grants AM 02443, AM 08153, and T1 AI-28, U. S. Public Health Service, Washington, D. C.At the time of this study Dr. Vaughan was the recipient of a Research Career Award, National Institutes of Health, Bethesda, Md.Requests for reprints should be addressed to John H. Vaughan, M.D., Department of Medicine, University of Rochester School of Medicine, 260 Crittenden Blvd., Rochester, N. Y. 14620. 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CASS, M.D., EDWARD S. MONGAN, M.D., RALPH F. JACOX, M.D., JOHN H. VAUGHAN, M.D., F.A.C.P.ERYTHROPOIETIC PROTOPORPHYRIA IN TWO SISTERS 1 September 1967Volume 67, Issue 3_Part_1Page: 596-602KeywordsAllergic diseasesAntigensCareers in researchDentistryHospital medicineMedical servicesRabies Issue Published: 1 September 1967 PDF DownloadLoading ...