Serum Iso-amylases
Authors: DAVID A. DREILING
Journal: Annals of Internal Medicine (1963)

Article1 February 1963Serum Iso-amylasesAn Electrophoretic Study of the Blood Amylase and the Patterns Observed in Pancreatic DiseaseDAVID A. DREILING, M.D., HENRY D. JANOWITZ, M.D., LAZAR J. JOSEPHBERG, M.D.DAVID A. DREILING, M.D.Search for more papers by this author, HENRY D. JANOWITZ, M.D.Search for more papers by this author, LAZAR J. JOSEPHBERG, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-2-235 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWe have recently summarized the evidence that the amylase of the serum is of heterogenous origin (1). Studies in this laboratory on the regulation of blood amylase levels (2, 3) have shown that [1] normal blood amylase is controlled in part at extrapancreatic sites, [2] blood amylase is lowered in states of increased carbohydrate utilization, and [3] the amylase responses to alterations of carbohydrate metabolism are markedly altered by liver disease but unaffected by total pancreatectomy. These findings led to the conclusion that the liver contributes to the blood amylase level and is an important site of regulation. Similar conclusions...References1. JANOWITZDREILING HDDA: The plasma amylase. Source, regulation and diagnostic significance. Amer. J. Med. 27: 924, 1959. CrossrefMedlineGoogle Scholar2. DREILINGJANOWITZMARSHALLHAEMMERLI DAHDDP: Relationship between blood amylase and factors affecting carbohydrate metabolism. I. Regulation of blood amylase levels in subjects without pancreatic disease. Amer. J. Dig. Dis. 3: 214, 1958. CrossrefMedlineGoogle Scholar3. DREILINGROSENTHALKASS DAWSM: Relationship between blood amylase and factors affecting carbohydrate metabolism. II. The influence of ACTH, hydrocortisone, liver disease and pancreatectomy. Amer. J. Dig. Dis. 4: 731, 1959. CrossrefMedlineGoogle Scholar4. MCGEACHINLEWIS RLJP: Electrophoretic behavior of serum amylase. J. Biol. Chem. 234: 795, 1959. CrossrefMedlineGoogle Scholar5. VAN LOONLIKINSSEGER EJMRAJ: Photometric method for blood amylase by use of starch iodine color. Amer. J. Clin. Path. 22: 1134, 1952. CrossrefMedlineGoogle Scholar6. MCGEACHINPOTTER RLBA: Electrophoretic behavior of rat serum. Nature (Lond.) 189: 751, 1961. CrossrefGoogle Scholar7. MCGEACHINGLEASONADAMS RLJRMR: Amylase distribution in extrapancreatic, extrasalivary tissue. Arch. Biochem. Biophys. 75: 402, 1958. CrossrefGoogle Scholar8. GRAYPROBSTEINHEIFITZ SHJGCJ: Clinical studies on blood diastase. 1. Low blood diastase as an index of impaired liver function. Arch. Intern. Med. 67: 805, 1941. CrossrefGoogle Scholar9. MCGEACHIN RL: Personal communication. Google Scholar10. HAVERBACKDYCEBUNDYWIRTSCHAFTEREDMONDSON BJBHFSKHA: Protein binding of pancreatic proteolytic enzymes. J. Clin. Invest. 41: 972, 1962. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DAVID A. DREILING, M.D.; HENRY D. JANOWITZ, M.D.; LAZAR J. JOSEPHBERG, M.D.Affiliations: New York, New YorkFrom the Pancreatic Research Laboratory, the Department of Surgery, and the Division of Gastroenterology, the Department of Medicine, The Mount Sinai Hospital, New York, New York.This study was supported in part by grant A-3889 (C) of the National Institutes of Health, United States Public Health Service, Bethesda, Maryland.Requests for reprints should be addressed to Henry D. Janowitz, M.D., The Mount Sinai Hospital, Fifth Avenue and One Hundredth Street, New York 29, New York. 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FitzGerald, P. FitzGerald and J. P. McMullin, to be published shortly by William Heinemann Medical Books, London, and by Charles C. Thomas, Fort Lauderdale, Florida.Differentiation of parotid and pancreatic amylase in human serumImmunoelectrophoretic study of isoamylaseElectrophoretic Study of Human IsoamylasesSerum enzymes in diagnosisSearch for a Naturally Occurring Amylase Inhibitor in Human SerumSeparation of Urinary Isoamylases on Cellulose AcetateThe interaction of human serum protein fractions with the starch-iodine complexThe electrophoretic nature of human amylase and the effect of protein on the starch-iodine reactionElectrophoretic non-identity of human salivary and pancreatic amylasesGlobulin-bound Amylase A Cause of Persistently Elevated Levels in SerumP. WILDING, B.SC., A.R.I.C., W. T. COOKE, M.D., F.R.C.P., G. I. NICHOLSON, M.R.A.C.P., M.R.C.P.An intrinsic disparity between amyloclastic and saccharogenic estimations of human serum isoamylase activitiesStudies of canine-liver amylaseElectrophoresisHyperamylasemia of Renal Origin in the Absence of AzotemiaElectrophoretic Behaviour of Rabbit Serum AmylaseChromatographic Heterogeneity of Rabbit Serum Amylase 1 February 1963Volume 58, Issue 2 Page: 235-244 Keywords Acute pancreatitis Blood Hospital medicine Medical services Pancreas Pancreatectomy Prevention, policy, and public health Proteins Research laboratories Surgery ePublished: 1 December 2008 Issue Published: 1 February 1963 PDF downloadLoading ...