tbuckley/cabot-search huggingface dataset:
Apparent Cure of Letterer-Siwe Disease
Authors: Howard R. Bierman
Journal: JAMA (1966)

AS MEDICINE advances, our concepts of disease entities also must change as experience dictates. Letterer-Siwe disease is a malignant histiocytosis of infants which is generally considered neither hereditary nor infectious.<sup>1,2</sup> The disease today is characterized by an acute onset with hepatosplenomegaly, generalized lymphadenopathy, progressive anemia, neutropenia, lymphocytosis, and often hemorrhagic phenomena. Multiple focal, osteolytic lesions of the skull, vertebrae, pelvis, and ribs are present. Histopathology is characterized by nonlipoid hyperplasia of the reticuloendothelial system. The disease in the infant is usually rapidly fatal within a few months. <h3>Report of Cases</h3><h3>History.—</h3> In January 1949, 8-month-old male twins were seen with a presumptive diagnosis of acute lymphatic leukemia, which subsequently was proved by biopsy to be nonlipoid reticuloendotheliosis (Letterer-Siwe disease)<sup>3</sup>(Figure). Multiple antibiotic therapy to the point of stool sterilization led to dramatic improvement of twin A. Antibiotics were then prescribed for twin B, who promptly showed the same
The Limits of Medical Malpractice
Authors: Richard A. Epstein
Journal: New England Journal of Medicine (1978)

In their provocative article in this issue of the Journal on the economic approach to medical malpractice, Schwartz and Komesar stress the ways in which medical-malpractice law can provide a patient-initiated control mechanism to improve the quality of medical care. They argue that physician negligence is best determined by an economic cost-benefit analysis by which negligent behavior is defined as "the failure to invest resources up to the level that equals the anticipated saving in damages." In their opinion professional custom, once the dominant standard, thus "serves only as a provisional substitute for the negligence rule."Contrary to their position, . . .
18F-FDOPA Accumulation in Traumatic Rib Fractures
Authors: Gilles N. Stormezand, Andor W.J.M. Glaudemans, Riemer H.J.A. Slart
Journal: Clinical Nuclear Medicine (2015)

F-FDOPA (6-[F]fluoro-L-DOPA) is used for the detection and staging of neuroendocrine tumors by visualizing the uptake of amine precursors in these tumors with high sensitivity and specificity. However, as this tracer is only available in a limited number of centers worldwide and the minority of the nuclear medicine specialists and referring clinicians is familiar with the distribution pattern of F-FDOPA, some physiological uptake patterns and pitfalls remain to be fully elucidated. Here, we present 2 cases of markedly increased uptake in the ribs after traumatic injury.
Loss of imprinting in choriocarcinoma
Authors: Kazumasa Hashimoto, Chihiro Azuma, Masayasu Koyama, Kazutomo Ohashi, Shoji Kamiura, Toshikatsu Nobunaga, Tadashi Kimura, Yoshihiro Tokugawa, Toshihito Kanai, Fumitaka Saji
Journal: Nature Genetics (1995)
A Hepatoid Adenocarcinoma of the Stomach With Liver Metastasis Mimicking Hepatocellular Carcinoma Detected by F-18 FDG PET/CT Imaging
Authors: Jian-hu Pan, Meng-jie Dong, Xiao-bo Ouyang
Journal: Clinical Nuclear Medicine (2011)

Hepatoid adenocarcinoma is a rare variant of adenocarcinoma that can occur in the stomach. Because of the low incidence of the disease, F-18 fluorodeoxyglucose positron emission tomography with computed tomography (FDG PET/CT) imaging studies for hepatoid adenocarcinoma of the stomach are scarce. We report the case of a 79-year-old man presenting with hepatoid adenocarcinoma of the stomach associated with hepatic metastases mimicking hepatocellular carcinoma on FDG PET/CT images. The possible presence of metastatic hepatoid adenocarcinoma should be considered in older patients with elevated serum α-fetoprotein and hepatic tumors with underlying chronic liver disease.
[308] PROTECTION AGAINST PHALLOIDIN HEPATOTOXICITY USING A SEMISYNTHETIC CHOLIC ACID DERIVATIVE, BALU-1
Authors: E. Herraez, R.I. Macias, J. Vazquez-Tato, C. Hierro, A.G. Blazquez, P. Martinez-Becerra, F. Jimenez, F. Gonzalez-San Martin, J.J. Marin
Journal: Journal of Hepatology (2007)
Acute leg ischaemia as a presentation of hyperleukocytosis syndrome in acute myeloid leukaemia
Authors: Rodolfo Mataix, M. Teresa Gómez-Casares, Conrado Campo, Santiago Jiménez, Juan J. Malcorra
Journal: American Journal of Hematology (1996)

a manifestation of lymphoma, and all died before receiving chemotherapy.If a patient with WM develops ascites, clinicians should consider the possibility that the disease has transformed into IL, especially if the patient has received alkylating agents.
Propranolol in the Treatment of Migraine
Authors: T.-E. Wideroe, T. Vigander
Journal: BMJ (1974)

Beta-blocking drugs that prevent cranial vasodilatation are potentially valuable in the prophylaxis of migraine. Forty-nine patients with either classic or common migraine were treated with propranolol 160 mg/day for an average of six months. The first 30 of the patients to respond well to this treatment then participated in a double-blind cross-over trial with a placebo and propranolol. The mean frequency of headache attacks was significantly reduced by propranolol. None of the patients expressed a preference for placebo. Propranolol seems to be an effective prophylactic for common and classic migraine but the antimigraine properties of the various beta-blocking agents probably differ.
The History of Dermatopathology
Authors: Mark S. Bernhardt
Journal: JAMA Dermatology (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Detection of aortic porcine valve dysfunction by maximum entropy spectral analysis.
Authors: R A Foale, T H Joo, J H McClellan, R W Metzinger, G L Grant, G S Myers, R S Lees
Journal: Circulation (1983)

A high-resolution method of spectral analysis, of the class generally called "maximum entropy method," was used in a study of aortic porcine valve closing sounds in 37 patients (ages 19 to 76). Spectra from 27 normal xenografts, implanted from 2 weeks to 61 months previously, were characterized by a dominant frequency peak, F1, at 89 +/- 15 Hz (mean +/- SD), with a lower amplitude peak, F2, at 154 +/- 25 Hz. Eight of nine patients with aortic porcine valve dysfunction were proved surgically to have leaflet degeneration or infection and had either F1 (139 +/- 54 Hz) and/or F2 (195 +/- 74 Hz) significantly higher than normal (p less than .001). In two patients with paravalvar leak but no leaflet abnormality, F1 and F2 were in the normal range. Estimation of F1 and F2 was highly reproducible and was unaffected by duration of implant up to 5 years. Spectral analysis of aortic porcine valve closing sounds by the maximum entropy method may be useful for detection of intrinsic xenograft dysfunction.
A clinical scoring system highly predictive of long-term kidney graft survival
Authors: Yohann Foucher, Pascal Daguin, Ahmed Akl, Michèle Kessler, Marc Ladrière, Christophe Legendre, Henri Kreis, Lionel Rostaing, Nassim Kamar, Georges Mourad, Valérie Garrigue, François Bayle, Bruno H. de Ligny, Mathias Büchler, Carole Meier, Jean P. Daurès, Jean-Paul Soulillou, Magali Giral
Journal: Kidney International (2010)
Care of Homebound Aged
Authors: JOHN D. CHASE
Journal: Annals of Internal Medicine (1975)

Comments and Corrections1 June 1975Care of Homebound AgedJOHN D. CHASE, M.D.JOHN D. CHASE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-82-6-858_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Doctor Paul A. L. Haber, Deputy Assistant Chief Medical Director for Professional Services, and I were gratified to read the report of Brickner and colleagues in the January issue on the care of homebound aged. Doctor Philip Brickner and his colleagues have correctly pointed out the importance of this kind of program in reaching the needs of the many patients who ordinarily might not come in to any health-care delivery system until it was determined that they need long-term institutional care. The editorial in that same issue gives further evidence of need for such a program.We... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOHN D. CHASE, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1975Volume 82, Issue 6 Page: 858-858 Keywords Long-term care ePublished: 1 December 2008 Issue Published: 1 June 1975 PDF downloadLoading ...
Evidence For the Presence of the Asialoglycoprotein Receptor in Coated Vesicles Isolated from Rat Liver
Authors: Clifford J. Steer, Doris A. Wall, Gilbert Ashwell
Journal: Hepatology (1983)

Coated vesicles were isolated from rat liver by a modification of the procedure described by Nandi et al. for bovine brain (Proc. Natl. Acad. Sci. U.S.A. 1982; 79:5881-5885). The hepatic receptor for asialoglycoproteins was shown to be an integral constitutent of these vesicles as evidenced by their ability to bind 125 I-asialo-orosomucoid in a specific and saturable manner. The specific binding activity of the purified vesicles was 17-fold greater than that of the original liver homogenate based on a protein determination. Binding was 97% latent and was made fully manifest only after removal of the clathrin coat and disruption of the exposed smooth membrane vesicles by detergent. Based on this finding, it was concluded that the binding protein for asialoglycoproteins was oriented toward the inner surface of the vesicle. In addition, evidence is presented that purification procedures employing detergent may result in coated vesicles deficient in one or more integral membrane proteins.
Fibroblast function and the maintenance of the aortic-valve matrix
Authors: A. W. M. VAN DER KAMP, J. NAUTA
Journal: Cardiovascular Research (1979)

The long-term behaviour of the aortic-valve allograft seems to be dependent on the maintenance of its matrix. Protein and collagen synthesis was studied in rat aortic-valves. Quantitative and qualitative methods proved the production of at least two protein pools. One protein pool is localised intracellularily with a 'turn-over' time of about 2 weeks, and a second pool is localised extracellularily with a 'turn-over' time of at least 8 weeks. The latter protein pool mainly consists of collagen.
Biological Activities of RUNX1 Mutants Predict Secondary Acute Leukemia Transformation from Chronic Myelomonocytic Leukemia and Myelodysplastic Syndromes
Authors: Shu-Chun Tsai, Lee-Yung Shih, Sung-Tzu Liang, Ying-Jung Huang, Ming-Chung Kuo, Chein-Fuang Huang, Yu-Shu Shih, Tung-Huei Lin, Ming-Chun Chiu, Der-Cherng Liang
Journal: Clinical Cancer Research (2015)

Transcription factor RUNX1 is essential for normal hematopoiesis. High mutation frequencies of RUNX1 gene in chronic myelomonocytic leukemia (CMML) and myelodysplastic syndromes (MDS) have been described, whereas the biologic significances of the mutations were not investigated. Here, we aimed to correlate the biologic activities of the RUNX1 mutants with the clinical outcomes of patients.We examined the mutational status of RUNX1 in 143 MDS and 84 CMML patients. Then, we studied the DNA and CBFβ binding abilities of all the RUNX1 mutants identified by using electrophoretic mobility shift assay and co-immunoprecipitation assay, and also determined their activities on target C-FMS gene induction by Western blotting and luciferase reporter assay. Using luciferase reporter assay, the relative biologic activities of each RUNX1 mutant could be quantified and correlated with the patient outcomes by statistical analyses.We observed that most RUNX1 mutants had reduced abilities in DNA binding, CBFβ heterodimerization, and C-FMS gene induction. The relative biologic activities of RUNX1 mutants were grouped into high- and low-activity mutations. Correlation of the activities of RUNX1 mutants with the clinical outcomes revealed that patients harboring lower activities of RUNX1 mutants had a higher risk and shorter time to secondary acute myeloid leukemia transformation in MDS and CMML. In multivariate analysis, low RUNX1 activity remained an independent predictor for secondary acute myeloid leukemia-free survival in MDS patients.The biologic activity rather than the mutational status of RUNX1 might be an indicator in predicting outcome of patients with MDS and CMML.
Review: Variable adaptation of molecular mechanisms in relation to the use of autologous striated muscle to augment myocardial function
Authors: C W PATTISON, D V E CUMMING, D G C. JONES, G GOLDSPINK, M J DUNN, M H YACOUB
Journal: Cardiovascular Research (1989)

Journal Article Review: Variable adaptation of molecular mechanisms in relation to the use of autologous striated muscle to augment myocardial function Get access C W PATTISON, C W PATTISON **From the Department of Cardiac Surgery, National Heart and Lung Institute (formerly Cardiothoracic Institute), Dovehouse Street, London Address for correspondence and reprints: C W Pattison, FRCS, Department of Cardiac Surgery, National Heart and Lung Institute, Dovehouse Street, London SW3 6LY. Search for other works by this author on: Oxford Academic PubMed Google Scholar D V E CUMMING, D V E CUMMING **From the Department of Cardiac Surgery, National Heart and Lung Institute (formerly Cardiothoracic Institute), Dovehouse Street, London Search for other works by this author on: Oxford Academic PubMed Google Scholar D G CLAYTON JONES, D G CLAYTON JONES †From The Royal Veterinary College, University of London, Royal College Street, London Search for other works by this author on: Oxford Academic PubMed Google Scholar G GOLDSPINK, G GOLDSPINK †From The Royal Veterinary College, University of London, Royal College Street, London Search for other works by this author on: Oxford Academic PubMed Google Scholar M J DUNN, M J DUNN **From the Department of Cardiac Surgery, National Heart and Lung Institute (formerly Cardiothoracic Institute), Dovehouse Street, London Search for other works by this author on: Oxford Academic PubMed Google Scholar M H YACOUB M H YACOUB Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 23, Issue 7, July 1989, Pages 593–600, https://doi.org/10.1093/cvr/23.7.593 Published: 01 July 1989 Article history Accepted: 23 February 1989 Published: 01 July 1989
A revised definition for cure of childhood acute lymphoblastic leukemia
Authors: C H Pui, D Pei, D Campana, C Cheng, J T Sandlund, W P Bowman, M M Hudson, R C Ribeiro, S C Raimondi, S Jeha, S C Howard, D Bhojwani, H Inaba, J E Rubnitz, M L Metzger, T A Gruber, E Coustan-Smith, J R Downing, W H Leung, M V Relling, W E Evans
Journal: Leukemia (2014)
Nutritional Dystrophy Among Children in Madras
Authors: S. T. Achar
Journal: BMJ (1950)

HEREDITARY HAEMORRHAGIC TELANGlECTASIA DITsJO7RNAL01 I, 1.-Died aged 82, but had suffered all his life from occasional nose-bleeding and had " spots " on his face and lips.II, 3.-The second husband of II, 2; suffered from recurrent nose-bleeding and had " spots " on his face like his sons.His brother (II, 5) was similarly affected, but no information could be discovered about the brother's children (III, 5 and 6) nor about his other brothers (II, 6, 7, and 8) and his sister (II, 4).III, 2.-Aged 60 and married but childless; has suffered from nose-bleeding only rarely throughout his life.He is said to have " spots " on his face just like his brothers.III, 3.-Examined aged 57, a single man; has suffered from severe nose-bleeding since childhood.The spots on his face appeared during the second decade, but have been more prominent during the last ten years.On examination he was very pallid, with multiple telangiectases of about 2 mm.diameter on the lips, several similar lesions on the tongue and soft palate, a few pinhead-sized telangiectases on the cheeks and ears, and diffuse telangiectasia over the tip of his nose.III, 4.-Aged 55. also single; was said to have had occasional nose-bleeding all his life and spots on his face like his brother (III.3). SummaryThree more families with hereditary haemorrhagic telangi- ectasia from the West Riding are reported.They illustrate again that epistaxis is usual in this condition, that arteriovenous aneurysm of the lung may be present, and that the defect is inherited as a simple dominant.We are grateful to Mr. P.
Renal and systemic hemodynamic responses to intravenous infusion of leukotriene C4 in the rat.
Authors: K F Badr, C Baylis, J M Pfeffer, M A Pfeffer, R J Soberman, R A Lewis, K F Austen, E J Corey, B M Brenner
Journal: Circulation Research (1984)

We studied the systemic and renal hemodynamic effects of leukotriene C4 (2 micrograms/kg per min for 5 minutes, iv) in the rat. During the period of its infusion, leukotriene C4 produced a significant elevation of mean arterial pressure and reductions in cardiac output and renal blood flow, as measured by electromagnetic flow probes. These effects were abolished by FPL55712 , a putative antagonist of sulfidopeptide leukotrienes, but not by saralasin or indomethacin. Leukotriene C4 also resulted in an average loss of 20% in plasma volume which, during the postinfusion period, perpetuated the low cardiac output state and thus provoked the release of angiotensin II. This vasoactive peptide sustained the elevation in systemic vascular resistance and the reduction in renal blood flow over a 70-minute postinfusion observation period. Consequently, glomerular filtration rate fell by approximately 50%. These angiotensin II-mediated effects were abolished by saralasin. Indomethacin prevented the leukotriene C4-induced loss of plasma volume and, thus, allowed for the significant recovery of cardiac output and renal blood flow during the post-infusion period, thereby preserving glomerular filtration rate. We conclude that leukotriene C4 exerts direct systemic and renal vasoconstrictor, as well as cardiodepressant effects, during the period of its infusion. By virtue of its vasopermeability enhancing effect, leukotriene C4 also results in an immediate loss of plasma volume, an effect which requires the presence of secondarily generated cyclooxygenase products and which perpetuates the hemodynamic abnormalities observed beyond the period of leukotriene C4 infusion.
Abstract 4908: The apoptotic response of the triple negative breast cancer cell line HCC1806 to chemotherapeutics
Authors: Checo J. Rorie, Jamie King, Relena Bryant, Kashenya Gurley
Journal: Cancer Research (2012)

Abstract Triple negative breast cancer is characterized by the loss or low expression of estrogen receptor, progesterone receptor, and HER2 proteins which have been targeted and established as somewhat effective therapy regiments in other breast cancer subtypes including luminal breast cancer. Since triple negative tumors are missing these established drug targets, there has been little advancement in the establishment of drug therapies to specifically target this breast cancer subtype. Triple negative breast cancer is described as aggressive due to its invasiveness and metastatic properties. One potential mediator of triple negative breast cancer aggressive behavior may be due to the fact that this breast cancer subtype may have as high as an 80% p53 tumor suppressor gene mutation rate. While the p53 gene may be mutated at high rates, it may be possible to design drugs to target some of the downstream genes that p53 transactivates, including the cyclin dependent kinase inhibitor p21 and the pro-apoptotic gene PUMA, in order to inhibit the further growth of the triple negative breast cancer cells. We previously reported that classic chemotherapeutics including actinomycin-D, staurosporine, and doxorubicin, were effective in eliciting apoptosis in breast cancer cell lines. We initially stressed breast cancer cell lines with all three chemotherapeutics listed above. We showed that all of the cell lines underwent significant apoptosis by 24hrs. Interestingly, the “normal” breast cancer cell line AG11132 had a delayed apoptosis response to doxorubicin treatment as compared to the breast cancer cell lines HCC1806, HCC70 and HCC1500. Therefore, we treated the breast cancer cell lines with a titration of various doxorubicin concentrations. Here we show that even at lower doxorubicin concentrations, a significant amount of apoptosis was measured at 24hrs in all of the cell lines including the triple negative breast cancer cell line HCC1806. We measured apoptosis by the physical characteristics as observed under light microscopy and by using the cell viability assay. We are currently monitoring the p53 tumor suppressor pathway network in all of these cells to determine the network's integrity and whether there is a direct or indirect involvement of p53 on the apoptosis responses. We are also further analyzing the chemotherapeutic agents to determine their effectiveness in killing breast cancer cells with limited cytotoxic effects to normal breast cells at various time-points. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4908. doi:1538-7445.AM2012-4908
Vascular Surgery: Principles and Practice
Authors: D. E. Strandness
Journal: JAMA (1987)

This is at least the third encyclopedic text of vascular surgery to appear in recent years. Its major sections include assessment of disease, medical treatment, peripheral occlusive disease, aneurysms, cerebrovascular disease, visceral arterial disease, vascular disorders of the upper limb, venous and lymphatic disorders, trauma, arteriovenous fistula, and miscellaneous topics related to infection, amputation, transplantation, and sexual function. The editors chose to enlist several "second-generation" vascular surgeons as contributors. This is certainly laudable, since it is common practice to see the same authors in similar volumes with little evident differences in the material that is covered. Most of the contributions are first-rate and valuable even for the experienced vascular surgeon. However, there are some disappointing aspects to the effort that must be mentioned. The chapter "The Clinical Examination of the Vascular Patient," has several problems. The vasospastic disorders are classified under "special varieties of occlusive peripheral vascular disease," which is