tbuckley/cabot-search huggingface dataset:
Unexpected Visitor on FDG PET/CT—Brown Adipose Tissue (BAT) in Mesentery in a Case of Retroperitoneal Extra-Adrenal Pheochromocytoma
Authors: Prathamesh Vijay Joshi, Vikram Ramchandra Lele
Journal: Clinical Nuclear Medicine (2012)

Fused positron emission tomography-computed tomography (PET/CT) technology has enabled the determination that nonmalignant fluorodeoxyglucose (FDG) uptake is observed in brown adipose tissue (BAT). FDG uptake in BAT is a known potential source of false-positive interpretations for PET. The typical locations of BAT include neck, supraclavicular area, mediastinum, and paravertebral intercostal spaces. Examples of atypical locations for BAT include posterior neck, left paratracheal area, axillae, perirenal area, and retrocrural area. We report PET/CT findings in a young male patient with malignant retroperitoneal extra-adrenal pheochromocytoma, who demonstrated FDG uptake in BAT at multiple locations including mesenteric BAT. We also propose catecholamine-secreting pheochromocytoma as a possible cause of BAT activation in our case.
Psychological Components and the Role of Adjunct Interventions in Chronic Idiopathic Urticaria
Authors: Jay Sperber, Janine Shaw, Suzanne Bruce
Journal: Psychotherapy and Psychosomatics (1989)

A psychological assessment (Symptom Checklist-90) was performed on 19 patients with chronic idiopathic urticaria. Compared to the control group, the urticaria patients had significantly higher scores on the scales of somatization, obsessive-compulsive, interpersonal sensitivity, depression, and anxiety. In general, the urticaria patients were quite anxious and experienced significant discomfort in interpersonal relationships. Based on the results of this study and other similar reports in the literature, it is suggested that adjunctive treatment of urticaria patients should focus primarily on stress management training aimed at relieving anxiety and group therapy which focuses on an exploration of interpersonal issues.
The Diagnosis of Vaginal Trichomoniasis
Authors: Joseph G. Lossick
Journal: JAMA (1988)

For many decades, clinicians worldwide have used direct microscopic examination of vaginal wet-mount preparations to identifyTrichomonas vaginalisinfections and have unquestioningly treated patients for this sexually transmitted infection solely on the basis of Papanicolaou-stained cervical smear reports. In this issue ofTHE JOURNAL, Krieger et al1have raised questions about the accuracy of these procedures. In a patient population with aTrichomonasprevalence of 15%, they found that the vaginal wet mount unerringly detected only 60% of theT vaginalisinfections. Papanicolaou smears were positive or suspicious for trichomonads in 63% of the infections, but 31% of the time they falsely identified infection when it was absent. These findings corroborate the findings of other investigators who have reported poor sensitivity with the wet mount (≤60%)2-5or who have documented false-positive Papanicolaou findings in the absence of other evidence ofT vaginalisinfection.3,6,7  See also p 1223.
Overseas trained doctors in Australia call for inquiry into registration system
Authors: R. Moynihan
Journal: BMJ (2010)

The Australian Doctors Trained Overseas Association is calling for a Senate inquiry into the system of registration and accreditation of doctors who trained outside Australia.

The call comes amid public concern that new assessment procedures may be causing unfair deregistrations of some doctors working in areas of high need, an issue raised last month in the Australian parliament.

The new procedures were introduced in the wake of the long running case of Jayant Patel, the foreign trained surgeon recently jailed in Australia after being found guilty of manslaughter ( BMJ 2010;341:c3646, doi:10.1136/bmj.c3646).

Under the changes, introduced in 2008, …
New tools for prevention of restenosis could decrease the 'oculo-stento' reflex
Authors: M Sturek
Journal: Cardiovascular Research (2002)

See article by Yasuda et al. [8] (pages 481–486) in this issue. 

Restenosis remains the major challenge to percutaneous coronary intervention procedures, despite substantial improvements. Standard balloon angioplasty results in restenosis in 30–50% of patients within several months after successful revascularization [1], requiring repeat target vessel revascularization. Placement of stents effectively reduces early restenosis due to elastic recoil of the artery, but there is increased late restenosis due to excessive intimal hyperplasia, yielding an overall restenosis rate of about 20–30% [2]. Although this restenosis rate is higher than desired, stenting has become the main interventional procedure for treatment of flow-limiting atherosclerotic lesions. In our clinic and numerous others almost 60–70% of critical lesions are stented. This dominant procedure has prompted the colloquial coining of the ‘oculo-stento reflex’—an interventionalist sees a lesion and reflexively stents it.

Rapamycin-coated stents have virtually eliminated restenosis in early trials [3–5]. After 8 months of follow-up there have been no adverse events [3], thus if rapamycin-coated stents have long-term efficacy beyond these initial trials … 

* Corresponding author. Tel.: +1-573-882-2640 or 573-882-3787; fax: +1-573-884-4276 sturekm{at}missouri.edu
Effects of changes in blood amino acid availability on muscle and liver amino-N exchange
Authors: N.K. Aagaard, J. Greisen, P. Ivarsen, K. Roelsgaard, P.W. Watt, H. Oerskov, H.E. Hansen, M.J. Rennie, H. Vilstrup, T. Groefte
Journal: Journal of Hepatology (2002)
The Relation between MultiDrugResistance-1 C3435T Polymorphism and Pulmonary Hypertension in Patients with Chronic Obstructive Pulmonary Disease
Authors: Hasan Yucel, Savas Sarıkaya, Ali Zorlu, Mehmet Birhan Yilmaz, İzzet Tandogan
Journal: Journal of the American College of Cardiology (2013)
Persistent dysfunction of regenerated endothelium after balloon angioplasty of rabbit iliac artery.
Authors: F F Weidinger, J M McLenachan, M I Cybulsky, J B Gordon, H G Rennke, N K Hollenberg, J T Fallon, P Ganz, J P Cooke
Journal: Circulation (1990)

This study investigated the vasodilator function of endothelium that regenerated after balloon angioplasty and the relation of this function to the extent of vascular injury and to subsequent intimal proliferation. Balloon angioplasty was performed in the left iliac artery of 47 New Zealand White rabbits. Vascular responses were examined in vitro 2 and 4 weeks after a "severe" injury (3.0-mm balloon) or a "moderate" injury (2.5-mm balloon). Both degrees of balloon injury caused complete endothelial denudation. Endothelial regrowth 2 weeks after either injury was confirmed histologically. Although the regenerated cells had irregular sizes and polygonal shapes and lacked the typical alignment in the direction of blood flow, immunocytochemical staining for factor VIII-related antigen identified these cells as endothelium. To study the vasodilator function of regenerated endothelium, rings of balloon-injured and control (contralateral) iliac arteries were suspended in organ chambers for recording of isometric force. Endothelium-dependent relaxation of balloon-injured vessels to acetylcholine and to the calcium ionophore A23187 were reduced at 2 and at 4 weeks after severe injury. After moderate injury, endothelium-dependent relaxations to these agents were reduced at 2 weeks but had normalized by 4 weeks. Endothelium-independent relaxation to sodium nitroprusside, however, was preserved in all study groups. Morphometric analysis revealed an inverse correlation between the degree of intimal thickening and maximal relaxation to acetylcholine (r = 0.45, p less than 0.01). Thus, there is a persistent attenuation of receptor- and nonreceptor-mediated endothelium-dependent relaxations after arterial injury. The regenerated cells have an altered morphological appearance, but staining for factor VIII-related antigen confirms their endothelial origin. The degree and duration of endothelial dysfunction depends on the severity of the initial injury and is related to the extent of intimal thickness.
Troponin T after endoscopic retrograde cholangiopancreatography: no evidence of harm
Authors: D. Martin, H.-U. Laasch, A-M. Kelly, R. Hammonds, L. Wilbraham, S. Sastry, A. England
Journal: Endoscopy (2006)

Background and study aims: It is well recognized that myocardial ischemia can occur during endoscopic retrograde cholangiopancreatography (ERCP). Acute arrhythmias and ST segment changes have been reported by a number of authors, but the longer-term sequelae with regard to permanent myocardial damage are not known. The aim of this study was to determine the presence or absence of significant injury to the heart muscle. Patients and methods: Sixty-two patients undergoing therapeutic ERCP were assessed clinically and with electrocardiography (ECG) for the presence of ischemic heart disease before the procedure. Extensive intraprocedural monitoring was carried out, postprocedural ECGs were recorded, and serum troponin T levels were measured. The ECGs were evaluated blindly by a single cardiologist. Results: In 61 of the 62 patients, no changes were observed between the ECGs before and after the procedure. One patient had postprocedural T wave inversion but a normal troponin T level, excluding myocardial damage. One patient with mild renal insufficiency and treated heart failure had borderline troponin T elevation (0.05μg/l) but no ECG changes. No complications of ERCP occurred. Conclusions: Whilst ECG and rhythm changes indicating transient myocardial ischemia do occur during ERCP, there is no evidence that myocardial damage takes place as a consequence of this.
Delayed overt gastrointestinal bleeding after cold endoscopic biopsy
Authors: F. Sarkis, H. Abu Daya, A. Sharara, A. Soweid, K. Barada
Journal: Endoscopy (2012)

We read with interest the study by Repici et al. [1] on the safety of cold polypectomy and biopsy. We hereby report on five patients who experienced overt gastrointestinal bleeding 24 – 48 hours after cold mucosal biopsy, four of whom required repeat endoscopy.
Delayed immune reconstitution after cord blood transplantation is characterized by impaired thymopoiesis and late memory T-cell skewing
Authors: Krishna V. Komanduri, Lisa S. St. John, Marcos de Lima, John McMannis, Steven Rosinski, Ian McNiece, Susan G. Bryan, Indreshpal Kaur, Sean Martin, Eric D. Wieder, Laura Worth, Laurence J. N. Cooper, Demetrios Petropoulos, Jeffrey J. Molldrem, Richard E. Champlin, Elizabeth J. Shpall
Journal: Blood (2007)
Differentiation of Smooth Muscle Cells from Human Amniotic Mesenchymal Cells Implanted in the Freeze-Injured Mouse Urinary Bladder
Authors: Tomonori Minagawa, Tetsuya Imamura, Yasuhiko Igawa, Naoki Aizawa, Osamu Ishizuka, Osamu Nishizawa
Journal: European Urology (2010)
Post-infarction electrocardiogram.
Authors: A. M. Porter
Journal: BMJ (1968)

Tricyclic Antidepressants SIR,-I am worried by one sentence in the article on tricyclic antidepressants (13 April, p. 102): "Jaundice, which is very un- common, is of the cholestatic type similar to that found in chlorpromazine."This is mis- leading.Jaundice is one of the more frequent side- effects reported from imipramine and imitrip- tyline, the most widely used members of the group.Its incidence is probably related to the amount of drug prescribed, and is only likely to be "very uncommon" with the newer compounds.I doubt, too, if the jaundice is always of the chlorpromazine type; this implies a cholestatic reaction which is usually benign.Some patients almost cer- tainly have a far more serious hepatic reac- tion, and death can result from liver-cell failure.-I am, etc.,
New Methods of Endoscopic Diagnosis of Digestive Tract Diseases in the Soviet Union
Authors: V. P. Strekalovsky
Journal: Endoscopy (1982)

The development of new methods and apparatus for laparoscopy and investigations of the small and large intestine makes it possible considerably to extend the boundaries of examinations. The method of fistuloscopy makes it possible to obtain more precise information about the branching and presence of cavities which cannot be seen during routine fistulography. The described methods and instruments are a stage on the road towards further improvement of the potentialities of endoscopy.
Rapid Estimation of Carboxyhemoglobin Level in Fire Fighters
Authors: Richard D. Stewart
Journal: JAMA (1976)

The analysis of expired breath with a portable electrochemical cell after carbon monoxide exposure provides a practical field method for the rapid estimation of carboxyhemoglobin. A fire fighter can collect and analyze his own breath sample for CO, an operation that requires 1 1/2 minutes. This simple technique has the accuracy necessary to determine compliance with the regulations governing occupational exposure to CO. (<i>JAMA</i>235:390-392, 1976)
389 LOW RISK OF HEPATOCELLULAR CARCINOMA RECURRENCE AFTER LIVER TRANSPLANTATION: A 3-YEAR FOLLOW-UP STUDY IN 78 PATIENTS WITH CHRONIC HEPATITIS B
Authors: P. Lampertico, M. Vigano, S. Bhoori, F. Agnelli, M.F. Donato, M. Bongini, M. Iavarone, C. Cotsoglou, A. Russo, L. Caccamo, G. Rossi, M. Colombo, V. Mazzaferro
Journal: Journal of Hepatology (2008)
'Referral into a void': opinions of general practitioners and others on single point of access to mental health care
Authors: Rosalind Raine, Simon Carter, Tom Sensky, Nick Black
Journal: Journal of the Royal Society of Medicine (2005)

In the past, British general practitioners (GPs) have referred patients to individual consultants.There is now a trend towards generic referral, whereby the specialist team is consulted via a single point of access.We examined the impact of this innovation on the relationship between GPs and specialists in mental health care.Sixteen groups of randomly selected GPs and mental health professionals (MHPs) in England discussed clinical scenarios involving the use of mental health interventions for patients with functional somatic symptoms.The meetings were audiotaped, transcribed and analysed to the point at which no major new themes were emerging.The final analysis was confined to a purposive sample of six of the sixteen groups, comprising 54 GPs and 15 MHPs.Although the rationale for the single point of access was clear to both GPs and MHPs, the approach erected boundaries because it impeded the establishment of professional relationships and transfer of knowledge.GPs thought the system reduced their capacity to be accountable to their patients and limited the potential for their own professional development.MHPs did not seem to be aware of GPs' concerns.Effective interprofessional management of individual patients depends upon confidence in colleagues' skills and good communication.Factors that hamper these must be addressed in the development of this system of referral.
Bateman's principles and human sex roles
Authors: Gillian R. Brown, Kevin N. Laland, Monique Borgerhoff Mulder
Journal: Trends in Ecology & Evolution (2009)

In 1948, Angus J. Bateman reported a stronger relationship between mating and reproductive success in male fruit flies compared with females, and concluded that selection should universally favour 'an undiscriminating eagerness in the males and a discriminating passivity in the females' to obtain mates. The conventional view of promiscuous, undiscriminating males and coy, choosy females has also been applied to our own species. Here, we challenge the view that evolutionary theory prescribes stereotyped sex roles in human beings, firstly by reviewing Bateman's principles and recent sexual selection theory and, secondly, by examining data on mating behaviour and reproductive success in current and historic human populations. We argue that human mating strategies are unlikely to conform to a single universal pattern.
Reviews and Notes: Gastroenterology: Gastrointestinal Cancers: Biology, Diagnosis, and Therapy
Authors: I. David Shocket
Journal: Annals of Internal Medicine (1996)

Literature of Medicine15 November 1996Reviews and Notes: Gastroenterology: Gastrointestinal Cancers: Biology, Diagnosis, and TherapyI. David Shocket, MDI. David Shocket, MDWashington Hospital Center, Washington, DC 20010.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-10-199611150-00028 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail AK Rustgi; ed. 663 pages. Philadelphia: Lippincott-Raven; 1995. $169.00. ISBN 0-7817-0276-3. Order phone 800-777-2295.The treatment of gastrointestinal cancer no longer involves only a gastroenterologist and a surgeon. As diagnostic imaging and treatment options have multiplied, the care of patients with cancer has evolved to include physicians and information from many disciplines: surgery, gastroenterology, oncology, pathology, and radiation therapy. Attempting to fill the void left by standard textbooks of gastroenterology, surgery, and oncology, Gastrointestinal Cancers successfully integrates information from these subspecialties to form a clear, concise view of current standards of therapy.Rustgi and his colleagues have chosen a format ... Author, Article, and Disclosure InformationAffiliations: Washington Hospital Center, Washington, DC 20010. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 November 1996Volume 125, Issue 10Page: 863KeywordsCancer treatmentClinical pathologyGastrointestinal cancersLibrariesMolecular biologyPatientsRadiation therapySub-specialty careSurgeonsSurgery ePublished: 15 August 2000 Issue Published: 15 November 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
IMMUNITY STUDIES OF ROCKY MOUNTAIN SPOTTED FEVER
Authors: Hideyo Noguchi
Journal: The Journal of Experimental Medicine (1923)

Freshly prepared mixtures of spotted fever virus and immune rabbit serum in neutral or superneutral proportions confer complete immunity on guinea pigs. The mixtures undergo a considerable loss in immunizing power when heated to 60 degrees C. for 20 minutes, but are still capable, if used in sufficient quantity, of conferring a degree of immunity on the vaccinated animal such that a subsequent experimental infection is rendered less severe and non-fatal. Unheated mixtures which had been preserved in the refrigerator at 4 degrees C. for a period of 32 days still retained a certain degree of immunizing property. The virus alone, or mixed with normal rabbit serum, when allowed to die out by prolonged preservation at refrigerator temperature, or when killed either by heating at 60 degrees C. for 20 minutes or by chemicals (chloroform, ether, xylene) does not induce immunity in guinea pigs.
EXPLORATORY USE OF CARDIAC MAGNETIC RESONANCE IMAGING IN LIVER TRANSPLANTATION; A ONE-STOP SHOP FOR PREOPERATIVE CARDIO-HEPATIC EVALUATION
Authors: Robert W. Biederman, Ngoc Thai, Jose Oliva, Michael Dishart, Bryan Veynovich, June Yamrozik, Ronald Williams, Saundra Grant, Jacqueline Poydence, Kusum Tom, Anil Singh, Swami Nathan, Asghar Fakhri
Journal: Journal of the American College of Cardiology (2011)
Ireland's staff shortages worsen
Authors: Doug Payne
Journal: BMJ (2001)

Staffing shortages in the Irish health system are worsening. University College Dublin recently cancelled training courses in computed tomography and mammogram for radiographers because the college does not have enough lecturers to meet the demand.

A shortage of radiographers with the necessary postgraduate training has led to a reduced capacity of many Irish hospitals to do computed tomography and has limited the country's breast cancer screening programme to women aged under 65 years.

At the same time, there are warnings that maternity services across the country are nearing breakdown because of the number of vacancies of both …
Abstract P5-01-10: Clinical-pathological features and outcomes of Invasive lobular (ILC) vs Invasive ductal (IDC) breast cancer (BC): a mono-institutional series.
Authors: A Ferro, C Eccher, R Triolo, A Caldara, MC Di Pasquale, LM Russo, NL De Carli, LV Cuorvo, M Barbareschi, F Gasperetti, G Berlanda, M Pellegrini, S Moroso, E Galligioni
Journal: Cancer Research (2012)

Abstract Purpose: The aim of our study was to investigate different clinico-biological behavior associated to ILC compared to IDC evaluating implications on survival outcomes Methods: We analyzed data from 3749 cases of IBC treated from 1995 to 2008 and categorized as having ILC, IDC and mixed/other. Associations between clinical-pathological variables and the ILC/IDC histotype were assessed using a χ2 test. Log-rank test and Cox regression model were performed to evaluate the impact of hystologic types on overall survival (OS), Event Free Survival (EFS) and Post-Progression Survival (PPS). Results: We identified 445 (12%) ILC, 3021 (80.5%) IDC, 149 mixed (ductal-lobular) BC (3.9%) and 134 other hystotypes (3.6%). Median age was 61 (25–97) years. Compared with IDC, ILC occurred significantly (p &amp;lt; 0.001) more likely in older age, larger in size (T≥2: 46 vs 34%) with frequent axilla involvement (43 vs 37%). It was associated with better differentiated tumors usually presenting low ki67, high level of ER expression and HER2 negative status. Mastectomies were more frequent (45%) in ILC than in IDC (37%). As ILC showed higher ER expression rates, adjuvant hormonal (± previous chemo) therapy was more frequently given to them than IDC (77 vs 64%). At a median follow up of 77 (0–272) months, there were not significant differences in EFS (81.4 vs 82.1%, p = 0.7) and OS (82.8 vs 84.6%; p = 0.19) between ILC vs IDC. Relapses, contralateral and second tumors were 65 (15%), 9 (2%) and 22 (5%) in ILC vs 404 (13%), 84 (2.8%) and 174 (5.7%) in IDC. Local recurences were 16 (3.6%) vs 175 (5.7%) in ILC vs IDC; preferential sites of distant relapses were similar in both histotypes. Median time to first event was 38.3 in ILC vs 35.23 months in IDC. PPS was 16.5 m (0–100) in ILC and 22.2 m (0–187) in IDC. ILC showed worse prognosis than IDC within luminal A (86.9 vs 93.5%; p = 0.003), C (70.4 vs 88.5%; p = 0.028) and in triple negative subtypes (50 vs 73.1%; p = 0.021). No difference in OS was seen for age, size, hormonal and nodal status, except in N &amp;gt;3 ILC pts, in whom a trend of worse prognosis (55.6 vs 60.2%) was observed. Conclusions: Despite the quite favorable biological pattern, ILC did not show a better outcomes than IDC. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P5-01-10.