tbuckley/cabot-search huggingface dataset:
CHRONIC ECZEMA AS A VARIANT OF DERMATITIS HERPETIFORMIS
Authors: S. GORDON, L. J. A. LOEWENTHAL
Journal: British Journal of Dermatology (1949)

British Journal of DermatologyVolume 61, Issue 11 p. 359-378 CHRONIC ECZEMA AS A VARIANT OF DERMATITIS HERPETIFORMIS S. GORDON M.B., Ch.B., M.R.C.P.Ed., S. GORDON M.B., Ch.B., M.R.C.P.Ed. Johannesburg, South Africa.Search for more papers by this authorL. J. A. LOEWENTHAL M.D., M.R.C.P., D.T.M. & H., L. J. A. LOEWENTHAL M.D., M.R.C.P., D.T.M. & H. Johannesburg, South Africa.Search for more papers by this author S. GORDON M.B., Ch.B., M.R.C.P.Ed., S. GORDON M.B., Ch.B., M.R.C.P.Ed. Johannesburg, South Africa.Search for more papers by this authorL. J. A. LOEWENTHAL M.D., M.R.C.P., D.T.M. & H., L. J. A. LOEWENTHAL M.D., M.R.C.P., D.T.M. & H. Johannesburg, South Africa.Search for more papers by this author First published: November 1949 https://doi.org/10.1111/j.1365-2133.1949.tb11045.xCitations: 7Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume61, Issue11November 1949Pages 359-378 RelatedInformation
Syndrome of Benign Nodular Adrenal Hyperplasia Associated with Feminization and Hyperprolactinemia
Authors: R. M. BOYAR
Journal: Annals of Internal Medicine (1974)

A 38-year-old man with severe gynecomastia, hypogonadism, and impotence had a pituitary tumor associated with markedly elevated plasma prolactin concentrations. Testicular biopsy showed a spermatogenic maturation arrest, with decreased Leydig cells. Endocrine evaluation showed normal plasma and urinary gonadotrophins. Plasma estradiol and urinary estrogen excretion and production rates were normal but the plasma testosterone was 0.06 µg/100 ml, in the prepubertal range. The associated finding of bilateral nodular adrenal hyperplasia in this patient suggests that the adrenal cortex may be a target organ for the trophic action of human prolactin and, as well, may play an etiologic role in the development of adrenal tumors or hyperplasia or both. The clinical findings of "idiopathic" gynecomastia and infertility caused by spermatogenic maturation arrest could represent less severe forms of this syndrome.
Urotensin II: better than somatostatin for portal hypertension?
Authors: David E. Newby, Rajiv Jalan
Journal: Hepatology (2000)

Urotensin-II (U-II) is a vasoactive 'somatostatin-like' cyclic peptide which was originally isolated from fish spinal cords, and which has recently been cloned from man.Here we describe the identification of an orphan human Gprotein-coupled receptor homologous to rat GPR14 and expressed predominantly in cardiovascular tissue, which functions as a U-II receptor.Goby and human U-II bind to recombinant human GPR14 with high affinity, and the binding is functionally coupled to calcium mobilization.Human U-II is found within both vascular and cardiac tissue (including coronary atheroma) and effectively constricts isolated arteries from non-human primates.The potency of vasoconstriction of U-II is an order of magnitude greater than that of endothelin-1, making human U-II the most potent mammalian vasoconstrictor identified so far.In vivo, human U-II markedly increases total peripheral resistance in anaesthetized non-human primates, a response associated with profound cardiac contractile dysfunction.Furthermore, as U-II immunoreactivity is also found within central nervous system and endocrine tissues, it may have additional activities.
Acute Pancreatitis Complicating the Insertion of a Self-Expandable Biliary Metal Stent
Authors: W. Van Steenbergen, L. Van Aken, E. Ponette
Journal: Endoscopy (1992)

A patient is reported who developed acute pancreatitis complicated by pseudocyst formation immediately after the insertion of a self-expanding metallic biliary stent via the percutaneous route. The distal end of the stent was positioned into the duodenum. Endoscopists should be aware of this potential complication of metallic biliary stents.
FOSL2 promotes leptin gene expression in human and mouse adipocytes
Authors: Christiane D. Wrann, Jun Eguchi, Aline Bozec, Zhao Xu, Tarjei Mikkelsen, Jeffrey Gimble, Heike Nave, Erwin F. Wagner, Shao-En Ong, Evan D. Rosen
Journal: Journal of Clinical Investigation (2012)

The adipocyte-derived hormone leptin is a critical regulator of many physiological functions, ranging from satiety to immunity. Surprisingly, very little is known about the transcriptional pathways that regulate adipocyte-specific expression of leptin. Here, we report studies in which we pursued a strategy integrating BAC transgenic reporter mice, reporter assays, and chromatin state mapping to locate an adipocyte-specific cis-element upstream of the leptin (LEP) gene in human fat cells. Quantitative proteomics with affinity enrichment of protein-DNA complexes identified the transcription factor FOS-like antigen 2 (FOSL2) as binding specifically to the identified region, a result that was confirmed by ChIP. Knockdown of FOSL2 in human adipocytes decreased LEP expression, and overexpression of Fosl2 increased Lep expression in mouse adipocytes. Moreover, the elevated LEP expression observed in obesity correlated well with increased FOSL2 levels in mice and humans, and adipocyte-specific genetic deletion of Fosl2 in mice reduced Lep expression. Taken together, these data identify FOSL2 as a critical regulator of leptin expression in adipocytes.
Recent Developments in Legal Aspects of Accreditation
Authors: Michael H. Cardozo
Journal: JAMA (1970)

In order to appreciate the recent developments in the legal aspects of accreditation in the United States, it is important to bear in mind the legal basis of the accreditation of higher education in this country. In many areas of elementary and secondary education and professional practice, most of the same considerations apply. The subject was thoroughly treated in a student comment in the<i>Cornell Law Quarterly</i>in 1966. The most significant aspect of accreditation in the United States is its "voluntary" character. This means that it arises out of the spontaneous action of private individuals and organizations, rather than from some governmental action. If you want to operate a bus system in a city, a railroad across state lines, or an international airline, you can find elaborate prescriptions in governmental statutes and regulations describing what you have to do before you can start and how you must operate when
Association of Serum Anti-Neuraminidase Antibody with Resistance to Influenza in Man
Authors: Brian R. Murphy, Julius A. Kasel, Robert M. Chanock
Journal: New England Journal of Medicine (1972)

The role of serum anti-neuraminidase antibody in resistance to influenzal illness was investigated by administration of wild-type influenza A/Hong Kong/1968 (H3N2) virus to volunteers who possessed varying levels of this antibody but who lacked antibody for the hemagglutinin surface antigen of the virus. Clinical response to the wild-type virus was related to the level of serum anti-neuraminidase antibody. Volunteers in whom influenzal disease with fever developed possessed low levels of serum antibody prior to challenge, whereas men who underwent inapparent infection had a significantly higher mean level of antibody for neuraminidase. Those with afebrile illness had an intermediate level of anti-neuraminidase antibody. Duration of virus excretion and maximal level of virus shed were also inversely related to the titer of serum anti-neuraminidase antibody. These findings provide evidence that antibody directed against influenzal neuraminidase is associated with resistance to clinical expression of influenza A virus in man.
Out-of-hours palliative care in the UK: perspectives from general practice and specialist services
Authors: D. Munday, J. Dale, M. Barnett
Journal: Journal of the Royal Society of Medicine (2002)

Palliative care within the community requires well coordinated multidisciplinary teamworking, involving both primary and secondary care practitioners. 'Out-of-hours'periods are a potentially problematic time for delivery of high quality care. We report on two national surveys—one of medical directors of out-of-hours general practitioner cooperatives, the other of medical directors of specialist palliative care units. The aim was to describe general practitioners'and specialists'perspectives on the availability and scope of community nursing and specialist palliative care services. The results point to wide variation in service provision within the community. The two groups differed strikingly in their perceptions, the general practitioners being much less positive than the specialists about the availability of specialist advice and admission to specialist units out of hours. Equitable out-of-hours palliative care services of high quality are unlikely to be achieved without dialogue between primary and secondary care based providers, local needs assessment and adequate resourcing.
In vivo antimalarial action of a lipophilic iron (III) chelator: Suppression of <i>plasmodium vinckei</i> infection by reversed siderophore
Authors: Simon D. Lytton, Mark Loyevsky, Brenda Mester, Jacqueline Libman, Irene Landau, Abraham Shanzer, Z. Ioav Cabantchik
Journal: American Journal of Hematology (1993)

Abstract We assessed in vivo antimalarial action of a lipophilic iron (III) chelator belonging to a new synthetic family of biomimetic siderophores previously termed reversed siderophores (RSFs). The family member, RSF ileu m2 , was chosen for its high membrane permeability and fast irreversible inhibition of human malaria parasite growth in vitro. [Shanzer A, et al., Proc Natl Acad Sci USA 88:6585, 1991 and Lytton SD, et al., Blood 81:214, 1993]. The lipophilic drug was administered to Swiss mice by subcutaneous route in fractionated coconut oil at a dosage of 0.37 g/kg every 8 hr with no adverse reactions observed. After 3–4 injections demonstrable suppression of Plasmodium vinckei petteri infection was observed and an additional 3–4 injections resulted in 2–3‐fold lower parasitemia with prolonged survival time over sham‐injected control mice.
SOX10 mutations in patients with Waardenburg-Hirschsprung disease
Authors: Véronique Pingault, Nadège Bondurand, Kirsten Kuhlbrodt, Derk E. Goerich, Marie-Odette Préhu, Aldamaria Puliti, Beate Herbarth, Irm Hermans-Borgmeyer, Eric Legius, Gert Matthijs, Jeanne Amiel, Stanislas Lyonnet, Isabella Ceccherini, Giovanni Romeo, Jill Clayton Smith, Andrew P. Read, Michael Wegner, Michel Goossens
Journal: Nature Genetics (1998)
Clinical Implications of Midventricular Obstruction in Patients With Hypertrophic Cardiomyopathy
Authors: Yuichiro Minami, Katsuya Kajimoto, Yutaka Terajima, Bun Yashiro, Dai Okayama, Shintaro Haruki, Takatomo Nakajima, Naomi Kawashiro, Masatoshi Kawana, Nobuhisa Hagiwara
Journal: Journal of the American College of Cardiology (2011)
Platelet Preservation
Authors: Phin Cohen, Frank H. Gardner
Journal: New England Journal of Medicine (1966)

THE use of platelet transfusions has been limited by the failure to preserve platelets by conventional storage technics. Preparation of fresh platelet concentrates on a "demand" basis is burdensome for any blood bank that is not involved in supporting a large leukemia service, where there would be constant need for platelet transfusions, permitting integration of the platelet program into the daily routine.A system is available for blood-component separation using whole blood collected in ACD NIH Formula A (ACDA).1 The basic principle of this system involves the addition of ACD B solution to platelet-rich plasma that has been derived from . . .
THE TIMING OF INSULIN DOSES
Authors: Frederick M. Allen
Journal: JAMA (1924)

The original plan of giving insulin just before meals is followed as a routine by most physicians, and works well in most cases. Difficulties are encountered, however, in certain severe cases requiring high dosage. In these there is a tendency to glycosuria or undue hyperglycemia before or after breakfast, and to hypoglycemia in the latter part of the day. Devices of increasing or decreasing the total dosage or diet, or altering the quantities of individual meals or doses, are still baffled by one or the other of these dangers. A fourth dose during the night is successful, but inconvenient. Accordingly, many practitioners resign themselves to the inherently bad and dangerous system of permitting glycosuria during at least a part of the day, feeling that this is at any rate the lesser of two evils. <h3>TIME OF DOSES</h3> In rare cases, the diabetes may be so severe that four doses during
Constricting arteries expand views of ischemic heart disease
Authors: Elizabeth Rasche González
Journal: JAMA (1980)

Without surgery, it was decided, the patient was as good as dead. "She was dreadfully afflicted with recurrent nocturnal anginal pains," recalled Albert A. Kattus, MD, of Inglewood, Calif, during the recent meeting of the American Heart Association (AHA) in Anaheim, Calif. "An angiogram showed a narrow place in one artery." Although the artery was only 60% occluded, the woman was scheduled for a coronary artery bypass graft. It was all the physicians could think of to do. Unknowingly, they were about to make medical history. The coronary artery had just been exposed, Kattus said, "when we suddenly saw the pattern of the electrocardiogram change. She was reenacting one of her episodes of angina. The artery itself was right there, before our eyes, and had gone into an intense constriction. As we saw it clamp down, we could feel it as though it were a tough piece of rope or
True and false left ventricular aneurysms. Propensity for the altter to rupture.
Authors: Z Vlodaver, J I Coe, J E Edwards
Journal: Circulation (1975)

Two cases are described of sudden death resulting from rupture of small chronic false aneurysm of the left ventricle with secondary hemopericardium. The cases support the point that rupture of chronic false left ventricular aneurysm tends to occur. This appears to be contrary to the potential for chronic true aneurysms of the left ventricle which tend not to rupture. Rupture of true left ventriuclar aneurysm in its deveoping stahe may, however, occur.
Internet anatomy 101. Accessing information on the World Wide Web
Authors: R. Sikorski
Journal: JAMA (1997)

A patient calls his physician to inquire about the risks of contracting malaria in the Caribbean. He tells the physician that he is planning a vacation in the Dominican Republic, but that a colleague has warned him that he could contract malaria there. He asks for advice.  While still on the telephone with the patient, the physician uses her personal computer to connect to the Internet and navigates to the Centers for Disease Control and Prevention (CDC) Travel Page on the World Wide Web (http://www.cdc.gov/travel/caribean.htm). The physician learns that malaria has been eradicated in all of the Caribbean islands except for Haiti and the Dominican Republic. Furthermore, the CDC reports, in the Dominican Republic, the risk is in rural areas but not in the island's tourist centers. The physician relates this information to the patient, who decides to stay in a resort hotel.
Ageing, telomeres, senescence, and liver injury
Authors: Matthew Hoare, Tapas Das, Graeme Alexander
Journal: Journal of Hepatology (2010)

Populations in developed countries continue to grow older and an understanding of the ageing process to allow healthy ageing carries important medical implications. Older individuals are more susceptible to most acquired liver disorders and more vulnerable to the consequences of liver disease. Accordingly, age is a critical determinant of outcome for hepatitis C virus infection and liver transplantation. In this review we describe changes in the ageing liver and discuss mechanisms of senescence at the cellular level. In particular, we focus on mechanisms by which inflammation, oxidative stress, and oncogenic stress accelerate cellular senescence. In the setting of chronic hepatic injury and inflammation, cellular senescence functions as an essential stress-response mechanism to limit the proliferation of damaged cells and reduce the risk of malignancy, but this benefit is achieved at the expense of senescence-related organ dysfunction. The dual role of cell senescence in chronic liver disease will make this an intriguing but challenging area for future clinical interventions.
Disseminated Lyme Disease Presenting With Nonsexual Acute Genital Ulcers
Authors: Justin J. Finch, Jenna Wald, Katalin Ferenczi, Saima Khalid, Michael Murphy
Journal: JAMA Dermatology (2014)

Nonsexual acute genital ulceration (NAGU) is a rare vulvar skin condition typically affecting girls and young women, characterized by acute onset of singular or multiple painful vaginal ulcers. The etiology of this ulcerative dermatosis has not been identified, although it has been associated with systemic infections. To our knowledge, this is the first report of an association with Lyme disease.A case of a woman with early disseminated Lyme disease presenting with NAGU is reported. A thorough workup ruled out other causes of genital ulceration, and the ulcers completely resolved after treatment with topical steroids and oral doxycycline.Although the etiology of NAGU is unknown, the vulvar ulcers may result from an exuberant immune response to infection. Most patients with NAGU exhibit nonspecific symptoms such as myalgias and fever, suggesting an infectious agent, but the majority have no identifiable pathogen. In addition to previously reported associations with systemic infection, which are reviewed herein, Lyme disease should be considered in women presenting with acute-onset genital ulcers.
Rheostat regulation of integrin-mediated leukocyte adhesion
Authors: Ivor S. Douglas, Themistocles Dassopoulos
Journal: Journal of Clinical Investigation (2007)

The homing of activated T lymphocytes to the gut in inflammatory bowel diseases is dependent on their coordinated, integrin-mediated adhesion and de-adhesion to substrates and blood vessel walls. In this issue of the JCI, Park and colleagues reveal a key modulatory role of a binding site within β integrins, known as the ADMIDAS domain, in controlling integrin de-adhesion in mice (see the related article beginning on page 2526). These observations add to our growing understanding of how integrin adhesiveness is regulated and raise the notion of the existence of a biological rheostat for lymphocyte homing. Disturbed migratory rheostat tone could account for variations in interindividual immune responses observed in patients with inflammatory bowel disease or other lymphocyte-mediated inflammatory disorders. These findings will inform future strategies to design small molecules for the treatment of a spectrum of chronic inflammatory conditions.
Reply to Yoshida et al.
Authors: T. Yano
Journal: Endoscopy (2009)

We thank Dr. Yoshida and colleagues for their remarks concerning our paper describing salvage endoscopic mucosal resection (EMR) in esophageal cancer patients with local failure after chemoradiotherapy [1]. In their letter, they reported a case of long-term survival after salvage EMR treatment for residual hypopharyngeal carcinoma after chemoradiotherapy. We consider that salvage EMR for hypopharyngeal cancer is the great challenge in terms of patients’ quality of life and organ preservation. Salvage total laryngopharyngectomy is profoundly invasive with a risk of severe complication, as with salvage esophagectomy. Therefore, we should be attempting to develop effective but less invasive salvage treatment options for local failure after chemoradiotherapy, with both esophageal cancer and head and neck cancers.
Terlipressin plus albumin infusion: an effective and safe therapy of hepatorenal syndrome
Authors: Juan Uriz, Pere Ginès, Andrés Cárdenas, Pau Sort, Wladimiro Jiménez, Juan Manuel Salmerón, Ramón Bataller, Antoni Mas, Miquel Navasa, Vicente Arroyo, Juan Rodés
Journal: Journal of Hepatology (2000)
Volume-Based Referral for Cancer Surgery: Informing the Debate
Authors: Brent K. Hollenbeck, Rodney L. Dunn, David C. Miller, Stephanie Daignault, David A. Taub, John T. Wei
Journal: Journal of Clinical Oncology (2006)

Purpose Mounting evidence suggests a relationship between hospital volume and outcomes after major cancer surgery; however, the absolute benefits of volume-based referral on a national basis are unclear. Patients and Methods Data from the Nationwide Inpatient Sample were used to measure the likelihood of operative mortality and a prolonged length of stay (LOS) after six cancer surgeries (prostatectomy, cystectomy, esophagectomy, pancreatectomy, pneumonectomy, and liver resection) between 1993 and 2003. Using sampling weights, the adjusted likelihood of the outcomes was used to calculate the number of lives saved (or prolonged LOS avoided) in the United States. Results The magnitude of the volume–operative mortality effect varied from an adjusted odds ratio (OR) of 1.3 (95% CI, 0.8 to 2.3) for cystectomy to 4.9 (95% CI, 2.4 to 10.1) for pancreatectomy. After accounting for varying rates of procedure utilization, the lives saved per 100 surgeries regionalized ranged from 0.2 (95% CI, 0.12 to 0.24 lives saved) for prostatectomy to 9.2 (95% CI, 6.7 to 10.4 lives saved) for pancreatectomy. The volume–prolonged LOS effect varied from an adjusted OR of 0.9 (95% CI, 0.5 to 1.6) for liver resection to 4.8 (95% CI, 3.5 to 6.7) for prostatectomy. After accounting for procedure use, the number of prolonged hospitalizations avoided ranged from −1.7 (95% CI, −11.3 to 3.6 hospitalizations) to 14.3 (95% CI, 12.9 to 15.4 hospitalizations) per 100 surgeries regionalized for liver resection and prostatectomy, respectively. Conclusion For patients undergoing major cancer surgery, the benefits of volume-based referral depend on the interplay between procedure utilization, the magnitude of effect, and the outcome chosen.
Is rationality really “bounded” by information processing constraints?
Authors: Paul A. Klaczynski
Journal: Behavioral and Brain Sciences (2000)

Extremist views on normative rationality fail to address differences in responding owing to intellectual ability or epistemic self-regulation. Individual difference research thus raises serious questions concerning the scientific utility of universal rationality and universal irrationality theories. However, recent data indicate that computational capacity theories do not account adequately for within-subject variability in normative responding, memory-reasoning independence, and instances of ability-normative reasoning independence.
Eosinophilia resulting from administration of recombinant granulocyte‐macrophage colony‐stimulating factor (rhGM‐CSF) in a patient with T‐γ lymphoproliferative disease
Authors: R. Gonzales‐Chambers, C. Rosenfeld, A. Winkelstein, L. Dameshek
Journal: American Journal of Hematology (1991)

Abstract A therapeutic trial of recombinant human granulocyte‐macrophage colony‐stimulating factor (rhGM‐CSF) was attempted in a patient with neutropenia and frequent infections secondary to T‐γ lymphoproliferative disease (T‐γ LPD). During the 14 days of subcutaneous rhGM‐CSF (500 μg/m 2 /day), the absolute eosinophil count increased from 0 to 9,455/μl. By contrast, the absolute neutrophil count decreased. Toxicity related to rhGM‐CSF included arthralgia and nonspecific chest pain. The possible mechanism for the rhGM‐CSF induced selective eosinophilia is discussed.
A case I will never forget: The wrong diagnosis
Authors: D. Haslam
Journal: BMJ (1997)

I will never forget Stan. It is now over 30 years since he died, but the circumstances of his death haunt me still.

He had been unwell for a couple of weeks, so we took him to the vet. Like most Welsh terriers he seemed to have the brains of a rocking horse, but for a couple of weeks his behaviour had been positively bizarre. …