tbuckley/cabot-search huggingface dataset:
Psychiatrists Strive to Help Children Heal Mental Wounds From War and Disasters
Authors: Lynne Lamberg
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Ultrastructure of the Normal Human Glomerulus
Authors: H. Friederici
Journal: JAMA (1967)

This monograph is another highly detailed description of the electron microscopic structure of the human renal glomerulus. The ultra-structure of the normal malpighian corpuscle is described and shown in 100 pages of text and 42 high-quality electron micrographs. The material studied consisted of 24 preoperative biopsies from patients free of renal disease. Previous light and electron microscopic studies of glomerular structure and development in man and in various animals are discussed, including a historical review. The main merit of this monograph, however, resides in the very careful investigation of the width of the glomerular basement membrane. On the basis of multiple planimetric determinations and detailed statistical analysis it is concluded that the basement membrane measures 3,300 to 3,400 Angstrom units. The variations from the mean were found to be approximately 20%, pointing to the difficulty inherent in any attempt to determine a standard measure for a biological spectrum. This careful
THE VALUE OF SULFÁTHIAZOLE OINTMENT IN THE TREATMENT OF PYOGENIC INFECTIONS OF THE SKIN
Authors: L. H. Winer
Journal: JAMA (1942)

Among the pyogenic infections of the skin, impetigo contagiosa is the most superficial and also the most common. A great deal of controversy has existed concerning the etiology of impetigo contagiosa as to whether it was caused by streptococci or by staphylococci. Recently White<sup>1</sup>revived the discussion of Sabouraud's claim that every case of impetigo contagiosa is of streptococcic origin. The history of this controversy is based on the work of Sabouraud,<sup>2</sup>Dohi,<sup>3</sup>Lewandowsky,<sup>4</sup>Tachau<sup>5</sup>and Epstein.<sup>6</sup>It is now established by the work of Engman,<sup>7</sup>Dohi, Lewandowsky, Jadassohn and his school and the more recent work of Epstein that impetigo may be of either streptococcic or staphylococcic origin. The remedies recommended for the treatment of impetigo contagiosa are legion. This fact proves that none of them is entirely satisfactory. Ammoniated mercury ointment in 1 to 5 per cent strength has probably been
Book Review Textbook of Pharmacoepidemiology Edited by Brian L. Strom and Stephen E. Kimmel. 498 pp. Chichester, England, John Wiley &amp; Sons, 2006. $160 (cloth); $80 (paper). 978-0-470-02924-4 (cloth); 978-0-470-02925-1 (paper).
Authors: Nicholas D. Moore
Journal: New England Journal of Medicine (2007)
A Student Becomes a Surgeon: 1932
Authors: Claude E. Welch
Journal: JAMA (1988)

The Massachusetts General Hospital opened its doors in 1821. I joined the staff as an intern in 1932 and, for nearly one third of the life of the hospital, have been an observer of the profound changes that have occurred in those 57 years. Many of the lessons learned in those early days still exert a strong influence on present decisions. This brief account may explain the forces exerted on a budding surgeon and may demonstrate some of the changes in the practice of surgery that have transpired since that time. Students in their final year of study at Harvard Medical School commonly spent a clinical clerkship in the Massachusetts General Hospital. On one occasion, three of us were walking down a corridor in the hospital, laughing about some trivial matter. Suddenly a hand was clapped on a shoulder and the tall, soldierly director of the hospital thundered, "Young man,
250 HEPATITIS C TREATMENT IN PATIENTS WITH GENOTYPE 2/3: 16 VS. 24 WEEKS; ANALYSIS OF OUTCOME, HRQOL, DIRECT AND INDIRECT COSTS
Authors: T. Dal Bianco, A. Grasso, A. Carlotto, F. Malfatti, A.M. Miotti, M.T. Giordani, A. Tramarin, P. Fabris
Journal: Journal of Hepatology (2010)
TREATMENT OF HUMAN HOOK WORM INFECTION WITH CARBON TETRACHLORIDE
Authors: L. Nicholls, G. G. Hampton
Journal: BMJ (1922)

18 Rccurrentgastric Gastro-enterostomy Typ3 6 Perigaslric adhe- ulcer working sions only. 20Gastric ulcer Twoindentationson Tyre 2 Ulcer on lesser greater curvature curvature.22 ?Nil abnormal Type 5 Nil found at operation.27 ?Nil abnormal Typa 4 Pyloric cicatrix. 28Gastric ulcer ?Pyloric sten3sis Type 4 Pylcric stenosi. 70Duodenal ulcer Small hypertonic Type 3 Duodenal ulcer.stoma ch 32 Gastric ulcer Hour-glass stomach Type 2 Twoulcersonlesser curvature.35 .. ..
651. Oligonucleotide-Mediated Gene Repair Restores Full Length SMN mRNA Expression in Mutant-SMN Murine Fibroblasts
Authors: Emanuela Bruscia, Rafal Ochalski, Michael Rice, Giuseppe Novelli, Federica Sangiuolo, Diane Krause
Journal: Molecular Therapy (2005)

of the growth factor GAP-43 and active Cdc42.The GIT1/β-PIX/ Cdc42/PAK pathway may play an important role in the biological activities of neurons.GIT1 also stimulates GAP-43 expression which may help promote regeneration of damaged axons and formation of new synapses.Therefore, GIT1 may have potential in the treatment of nerve injury.
Three years of specific immunotherapy with house‐dust‐mite extracts in patients with rhinitis and asthma: significant improvement of allergen‐specific parameters and of nonspecific bronchial hyperreactivity
Authors: C. E. Pichler, A. Helbling, W. J. Pichler
Journal: Allergy (2001)

Twenty‐seven patients with allergy to house‐dust mite and the clinical symptoms of perennial rhinitis and/or mild asthma were treated with specific immunotherapy (SIT) with standardized extracts of house‐dust mite for 3 years. The success of therapy was evaluated in yearly intervals by 1) subjective rhinitis and asthma scores 2) allergen‐specific skin and conjunctival tests 3) nonspecific bronchial hyperreactivity to methacholine 4) medication scores of rhinitis and asthma. SIT induced a significant improvement of all parameters already after 1 year, with further improvement in the follow‐up measurements at 2 and 3 years. We found a constant improvement of the rhinitis and asthma symptom scores, a reduced reactivity in the skin prick and conjunctival provocation tests, and a constantly increasing reduction of bronchial hyperreactivity to methacholine. Concomitantly, the use of medication (topical corticosteroids, β 2 ‐mimetics, and antihistamines) was reduced. Our data support the concept that SIT with standardized extracts of house‐dust mite results in an improvement of allergen‐specific parameters in patients with perennial rhinitis and intermittent asthma. This beneficial effect of SIT on allergen‐specific immune parameters seems to induce also a diminution of nonspecific bronchial hyperreactivity and enables reduction of symptomatic treatment.
When Should Data and Safety Monitoring Committees Share Interim Results in Cardiovascular Trials?
Authors: Jeffrey S. Borer
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Randomized Trial of Robot-Assisted Laparoscopic Radical Cystectomy
Authors: Bernard H Bochner, Daniel D Sjoberg, Vincent P Laudone
Journal: New England Journal of Medicine (2014)

In a single-center, randomized trial comparing robot-assisted laparoscopic radical cystectomy with open surgery, there was no significant between-group difference in the rates of perioperative complications of grade 2 to 5.
THE COMMITTEE ON THE COST OF MEDICAL CARE
Authors: Ray Lyman Wilbur
Journal: JAMA (1928)

<h3>To the Editor:</h3> —A considerable number of inquiries regarding the origin, the plans and the aims of the Committee on the Cost of Medical Care, of which I am the chairman, prompts me to make public the following facts: "What is behind this new committee?" and "What is it driving at?" appear to be the questions in the minds of most correspondents. Through your columns I should like to answer these questions as clearly as possible. The committee was organized in May, 1927, at a conference called by ten physicians (three of whom are in private practice), three economists and three nonmedical persons engaged in public health work, and attended by approximately sixty persons representing these three fields and the general public. It was a result of a similar but considerably smaller conference held a year earlier, and of a great deal of correspondence with prominent medical practitioners, sanitarians, economists
The Inferior Vena Cava Filter
Authors: Eric K. Hoffer
Journal: JAMA Internal Medicine (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Waits over 18 months lengthen in Wales
Authors: R. Dobson
Journal: BMJ (1998)

More than 2000 people in Wales have been on hospital waiting lists longer than 18 months, according to new government figures.

That represents a 51% increase on the same time last year and comes more than a decade after waiting list initiatives were pioneered by the Welsh Office. The increase is in contrast to figures for England published recently in …
Alpha hydroxyacids modulate stratum corneum barrier function
Authors: E. BERARDESCA, F. DISTANTE, G.P. VIGNOLI, C. ORESAJO, B. GREEN
Journal: British Journal of Dermatology (1997)

Alpha hydroxyacids (AHAs) are used to enhance stratum corneum desquamation and improve skin appearance. The purpose of this study was to evaluate whether some AHAs improve skin barrier function and prevent skin irritation. Eleven healthy subjects (aged 28 +/- 6 years, mean +/- SD) entered the study. Six test sites of 8 x 5 cm (four different AHAs, vehicle only (VE) and untreated control (UNT) were selected and randomly rotated on the volar arm and forearm. The four different AHAs at 8% concentration in base cream were glycolic acid (GA), lactic acid, tartaric acid (TA) and gluconolactone (GLU). The products were applied twice a day for 4 weeks (2 mg/cm2). At week 4, a 5% sodium lauryl sulphate (SLS) challenge patch test was performed under occlusion for 6 h (HillTop chamber, 18 mm wide) on each site. Barrier function and skin irritation were evaluated by means of evaporimetry (Servomed EP-1) and chromametry (a* value, Minolta CR200) weekly, and at 0, 24 and 48 h after SLS patch removal. No significant differences in transepidermal water loss (TEWL) and erythema were observed between the four AHAs at week 4. After SLS challenge, GLU- and TA-treated sites resulted in significantly lower TEWL compared with VE, UNT (P < 0.01) and GA (P < 0.05) both at 24 and 48 h. Similarly, a* values were significantly reduced after irritation in GLU- and TA-treated sites. This study shows that AHAs can modulate stratum corneum barrier function and prevent skin irritation; the effect is not equal for all AHAs, being more marked for the molecules characterized by antioxidant properties.
Government targets are distorting patient-doctor relationships
Authors: Z. Kmietowicz
Journal: BMJ (2008)

The system that pays GPs for meeting clinical targets should be “downsized and downscaled” to preserve the relationship between doctors and patients, an independent think tank has concluded.

Civitas says in a new report that the quality and outcomes framework (QOF), the performance related scheme that pays general practices for meeting targets, is undermining patients’ trust in their GPs and the professional integrity that patients expect of them. This is because it offers financial incentives that can distract GPs from providing all round, high quality personalised care.

The framework, which was introduced as part of the new GP contract in 2004 as a means to improve clinical care by linking payments to targets, makes up to a third of …
Attenuated Progression of Coronary Artery Disease After 6 Years of Multifactorial Risk Intervention
Authors: Josef Niebauer, Rainer Hambrecht, Tamás Velich, Klaus Hauer, Christian Marburger, Barbara Kälberer, Claus Weiss, Eberhard von Hodenberg, Günter Schlierf, Gerhard Schuler, Rainer Zimmermann, Wolfgang Kübler
Journal: Circulation (1997)

Background It was the aim of this study to assess the long-term effects of physical exercise and low-fat diet on the progression of coronary artery disease. At the beginning of the study, 113 male patients with coronary artery disease were randomized to an intervention group (n=56) or a control group (n=57); 90 patients (80%) could be reevaluated after 6 years. Methods and Results Patients in the intervention group (n=40) showed a reduction in total serum cholesterol (6.03±1.03 versus 5.67±1.01 mmol/L; P &lt;.03) and triglyceride levels (1.94±0.8 versus 1.6±0.89 mmol/L; P &lt;.005) and maintained their initial body mass index (26±2 versus 27±2 kg/m 2 ; P =NS), but results were not statistically different from the control group (n=50) (total serum cholesterol, 6.05±1.02 versus 5.79±0.88 mmol/L; triglycerides, 2.25±1.28 versus 1.85±0.96 mmol/L [both P =NS]; body mass index, 26±2 versus 28±3 kg/m 2 [ P &lt;.0001]). In the intervention group, there was a significant 28% increase in physical work capacity (166±59 versus 212±89 W; P &lt;.001), whereas values remained essentially unchanged in the control group (165±51 versus 170±60 W; P =NS; between groups, P &lt;.05). In the intervention group, coronary stenoses progressed at a significantly slower rate than in the control group ( P &lt;.0001). Energy expenditure during exercise was assessed in a subgroup; patients with regression of coronary stenoses spent an average of 1784±384 kcal/wk (≈4 hours of moderate aerobic exercise per week). Multivariate regression analysis identified only physical work capacity as independently contributing to angiographic changes. Conclusions After 6 years of multifactorial risk intervention, there is significant and persistent improvement in lipoprotein levels and physical work capacity, which results in a significant retardation of disease progression. These beneficial effects appear to be largely due to chronic physical exercise.
A Correlative Biomarker Analysis of the Combination of Bevacizumab and Carboplatin-Based Chemotherapy for Advanced Nonsquamous Non–Small-Cell Lung Cancer: Results of the Phase II Randomized ABIGAIL Study (BO21015)
Authors: Tony Mok, Vera Gorbunova, Erzsebet Juhasz, Barna Szima, Olga Burdaeva, Sergey Orlov, Chong-Jen Yu, Venice Archer, Magalie Hilton, Paul Delmar, Celine Pallaud, Martin Reck
Journal: Journal of Thoracic Oncology (2014)
Segmental Contour Mapping Pattern in a Patient With Breast Carcinoma
Authors: David Tu Kim Nguyen, Sun Yong Kim, Julia Lim, Manish Varma
Journal: Clinical Nuclear Medicine (2004)

A 56-year-old woman status post bilateral mastectomies, chemotherapy, and radiation treatment of breast cancer presented with dyspnea and associated pleuritic chest pain, fatigue, and chest heaviness. Imaging studies including a chest radiograph, lower extremity color Doppler ultrasound, computed tomography pulmonary angiogram, and high-resolution chest CT (HRCT) were all negative. Lung scan revealed contour mapping of the bronchopulmonary segments, a pattern which can be seen in patients with tumor emboli syndrome or lymphangitic carcinomatosis. A pulmonary angiogram with microvascular cytologic sampling revealed no pulmonary embolus but confirmed the presence of malignant cells identical to the patient's breast cancer.
Infection control revisited: dilemma facing today's bronchoscopists.
Authors: P. J. Hanson, D. J. Jeffries, J. C. Batten, J. V. Collins
Journal: BMJ (1988)

The emergence of the acquired immune deficiency syndrome has provoked a widespread review of policies for infection control. Incomplete knowledge about the human immunodeficiency virus (HIV), hepatitis B virus, and mycobacteria has until now been compensated for by adopting "overkill" precautions for patients who were thought to harbour these organisms. This policy is no longer tenable, given the difficulty in identifying infected patients. The control of infection in hospitals must instead be based on the routine use of high standards of hygiene that are adequate to contain all pathogens. Attempts by bronchoscopists to formulate such a policy have been frustrated by the lack of a suitable disinfectant and by ignorance of the susceptibility of microorganisms to cleaning and disinfection in a clinical environment.
Two cases of falciparum malaria acquired in Britain.
Authors: D Whitfield, C F Curtis, G B White, G A Targett, D C Warhurst, D J Bradley
Journal: BMJ (1984)

Two cases of severe falciparum malaria contracted in the United Kingdom occurred in residents of Sussex, living 10 and 15 km from Gatwick airport. One patient was the landlord of a public house much frequented by aircrew, and the other was the wife of a worker at the airport, who travelled close to the public house on the probable date she contracted her infection. Transmission was most probably due to the bite of an infected imported tropical anopheline mosquito transported in a vehicle from the aircraft to the site of transmission during the very hot and humid weather of July 1983. Prevention of further cases depends on increased diligence in "blocks-away" destruction of insects in aircraft flying from endemic areas, but there is a need for more study of acceptable alternative ways of delivering the insecticide. This "airport malaria" is well recognised on the continent, and physicians should be aware of its existence in those who have not travelled abroad but live or work near international airports.
GASTRIC TETANY IN THE ADULT
Authors: W. K. Irwin
Journal: BMJ (1913)

NOV. 8, 19X3 painless, alnd uisually easily retained for a sufficielnt lengtlh of tiine to lhave a good chance of exerting its disinfectant and astringent properties.The folloNving brief notes will serve to illustrate the effects of albargin in differenit types of cases.CASE I.-Acute Bacillary i)ysentery Resisting Puryotice Treat- vi.ent, buit (C!ured by §1lLice A1lbarhit llowvel JVoshes.An In.ian (Chiristian.miale, aged 38, admitte(d for suspected cholera, lut proved to be a case of acute bacillary dysentery.Fromii eleven to seveniteeni stools ('aily, containing imiuclh blood ainld miuctus.No improvement after eight (lays' treatment witl castor oil aiid opiumtll, followed by salines.One pinit of albargin of the strength of 1 grain in 1 oz.(approximately 1 in 500 solni- tion), giveln as ani eienea, and inicreased to 11 pints on eacl of the following two days.The evening temperature, wlhichl bad )eell rising to 99`anid a little over, fell to 970; the blood(ldis- appeared at onice, alid the muilcus finally after six days.by wlhiclh time the stools hoad become reduced to onie or t\wvo liealthy motions d(aily, anid lie was oni solid food.He wsas (OIS- charged fonr days later, an)d camiie to see miie several tim-les during the niext tlyree miionitlhs, anid lhas remainied well.h'lec rapi( improvement after the failure of other treatment in. a severe case, N hicli was tlir ateiling to becomiie clhrolic, wvas CISE IT.--Chironiic Bacillairy Dysentery of Eight Mron/hts' Duration Rapldly Cureid y Atby1brgin.European female, aged 17, admitted for cironic idysentery for eiglt monitlhs witlhotut intermission.No amoebae founll( onl repeated examiiniationi cf the stools, wvlich conitained blood anld mulElcus anid numbered tlhree to fotur daily.beinig passed with
Acquired amegakaryocytic thrombocytopenia purpura and eosinophilic fasciitis: A long relapsing and remitting course
Authors: Uzair B. Chaudhary, Stephen F. Eberwine, Kristen M. Hege
Journal: American Journal of Hematology (2004)

Abstract Acquired amegakaryocytic thrombocytopenia purpura (AATP) is a rare disorder of unclear etiology characterized by severe thrombocytopenia, preservation of erythroid and myeloid cell lines, and absence of megakaryocytes in the bone marrow. We report herein a patient who developed eosinophilic fasciitis preceding a diagnosis of AATP. Longitudinal follow‐up and treatment of this individual show a relapsing and remitting disease course which appears closely related to the dosing of cyclosporine. Later in the treatment course, dosing of anti‐thymocyte globulin (ATG) appeared to have important beneficial contributions in the management of this patient's disease. Am. J. Hematol. 75:146–150, 2004. © 2004 Wiley‐Liss, Inc.