tbuckley/cabot-search huggingface dataset:
Terminal megakaryocytic differentiation of TF-1 cells is induced by phorbol esters and thrombopoietin and is blocked by expression of PML/RARα fusion protein
Authors: U Testa, F Grignani, HJ Hassan, D Rogaia, R Masciulli, V Gelmetti, R Guerriero, G Macioce, C Liberatore, T Barberi, G Mariani, PG Pelicci, C Peschle
Journal: Leukemia (1998)
Comparison between Local Injections of Silicone Oil and Hydrocortisone Acetate in Chronic Arthritis
Authors: M. Corbett, M. H. Seifert, C. Hacking, S. Webb
Journal: BMJ (1970)

One of three preparations—silicone oil, hydrocortisone acetate, and hydrocortisone acetate plus saline—was injected into 22 osteoarthritic and 49 rheumatoid knees. Silicone injected into stiff, dry, grating knees which were the site of chronic arthritis did not promote better movement than did hydrocortisone alone. Hydrocortisone plus saline, however, appeared to be more effective than silicone or hydrocortisone alone in increasing movement in rheumatoid knees. The maximum increase in movement was found to occur three weeks after each of the three different injection preparations.
HLA-B27 associated reactive spondyloarthropathies in a Dutch military hospital.
Authors: R J Lionarons, M van Zoeren, J N Verhagen, H A Lammers
Journal: Annals of the Rheumatic Diseases (1986)

Forty-two male patients with reactive spondyloarthropathies in a Dutch military hospital are described with mean age of onset 21.9 years. Peripheral arthritis or sacroiliitis was present in all, eye symptoms in 21 (50%), and genitourinary disease in 15 (35.7%). Evidence of antecedent sexually acquired or enterocolitic infection was found only in three (7.2%). HLA-B27 antigen was detected in 34 (81%) of 42 patients. Additional data suggest that reactive spondyloarthropathies are the most common form of inflammatory arthritis in young men.
Malignant Pleural Mesothelioma–Targeted CREBBP/EP300 Inhibitory Protein 1 Promoter System for Gene Therapy and Virotherapy
Authors: Takuya Fukazawa, Junji Matsuoka, Yoshio Naomoto, Yutaka Maeda, Mary L. Durbin, Noriaki Tanaka
Journal: Cancer Research (2008)

Abstract Gene therapy and virotherapy are one of the approaches used to treat malignant pleural mesothelioma. To improve the efficiency of targeting malignant mesothelioma cells, we designed a novel system using the promoter of the CREBBP/EP300 inhibitory protein 1 (CRI1), a gene specifically expressed in malignant pleural mesothelioma. Four tandem repeats of the CRI1 promoter (CRI1−138 4x) caused significantly high promoter activity in malignant pleural mesothelioma cells but little promoter activity in normal mesothelial cells and normal fibroblasts. The recombinant adenoviral vector expressing proapoptotic BH3-interacting death agonist or early region 1A driven by the CRI1−138 4x promoter induced cell death in malignant mesothelioma cells but not in normal cells. Moreover, these viruses showed antitumor effects in a mesothelioma xenograft mouse model. Here, we describe a novel strategy to target malignant mesothelioma using the CRI1−138 4x promoter system. [Cancer Res 2008;68(17):7120–9]
Dual chemotherapy and photodynamic therapy in an HT-29 human colon cancer xenograft model using SN-38-loaded chlorin-core star block copolymer micelles
Authors: Cheng-Liang Peng, Ping-Shan Lai, Feng-Huei Lin, Steven Yueh-Hsiu Wu, Ming-Jium Shieh
Journal: Biomaterials (2009)
LRP: a bright beacon at the blood-brain barrier
Authors: Joachim Herz
Journal: Journal of Clinical Investigation (2003)

Ever more unexpected roles for the LDL receptor gene family in a variety of cellular signaling pathways continue to emerge. Three recent studies now add another function to this collection. By interacting with active tissue-type plasminogen activator, LDL receptor–related protein appears to control permeability of the blood-brain barrier, vascular tone, and the expression of MMPs. All of these parameters impact upon postischemic infarct size following stroke. These novel findings are discussed in the context of known mechanisms of signaling by the LDL receptor family.
An Integrative Model for the Treatment of Psychosomatic Disorders
Authors: Hector Warnes
Journal: Psychotherapy and Psychosomatics (1976)

The functions and dysfunctions of slow wave sleep and of REM sleep and its associated dreams have a tremendous significance in understanding the psychosomatic model of illness and in establishing preventive strategies. Ten patients suffering from a variety of psychosomatic illnesses spent 3–4 nights sleeping at the Dream Laboratory. A psychiatric evaluation was carried out and those suffering from schizophrenia, severe depression, acute stage of physical illness and organic deficits were not accepted for the study. It was postulated that increased psychosomatic 'penetrance' as measured by poverty of fantasy life, feelings of helplessness, absence of dream reports, vacant and contrived emotional expression and poor psychological mindedness would be correlated with psychological test results (IPAT Anxiety Scale and Zung Depression Rating Scale), manifest dream content analysis and particular REM and stage 4 deficit. The higher psychosomatic 'penetrance' in our study was not found in all patients with a psychosomatic diagnosis but rather in those patients suffering from ulcerative colitis. The degree of 'penetrance' was related to specific physiological, psychological and interpersonal parameters. Based on these findings a spectrum of clinical and physiological criteria of selection for particular therapeutic intervention was presented.
Childhood Lead Poisoning in 1994
Authors: Lynn R. Goldman
Journal: JAMA (1994)

Lead poisoning is one of the worst environmental threats to children in the United States and is also entirely preventable.<sup>1</sup>An increased understanding of the adverse effects of lead poisoning—neurological, endocrinological, hematological, reproductive, and growth—resulted in the Centers for Disease Control and Prevention lowering the acceptable blood lead level three times in the last 20 years.<sup>2</sup> The article by Pirkle et al<sup>3</sup>documents the dramatic decrease in blood lead levels from 0.62 to 0.14 μmol/L (12.8 to 2.8 μg/dL) between 1976 to 1980 and 1988 to 1991. Most significantly, the percentage of US children aged 1 to 5 years with blood lead levels 0.48 μmol/L (10 μg/dL) or greater decreased from 88.2% to 8.9%. Decreases in blood lead levels occurred for all age and income groups. This is surely one of the most remarkable public health achievements of the decade and is undoubtedly the result of government
Alterations in preload and ejection phase indices of left ventricular performance,.
Authors: L S Rankin, S Moos, W Grossman
Journal: Circulation (1975)

Ejection phase indices such as mean velocity of circumferential fiber shortening (V-cf), ejection fraction (EF), and mean normalized systolic ejection rate (MSER) are thought to reflect the level of left ventricular (LV) inotropic state. Although known to be influenced by changes in afterload, their response to altered preload is less certain. This question was examined in ten normal subjects studied in the supine position and after 10 min of 75 degree head-up tilt. Echo VL diameter (D) and carotid pulse recordings were used to calculate LV ejection time, V-cf, MSER, LV end-diastolic and stroke volumes (EDV and SV, by D3 formula), and ejection fraction. Systemic blood pressure (BP)was measured by cuff, and heart rate (HR) counted from the ECG. Calculated LVEDV decreased with tilt (115 plus or minus 8 to 82 plus or minus 7 ml, P smaller than 0.001), as did SV (81 plus or minus 6 to 54 plus or minus 6 ml, P smaller than 0.001), and ejection time (0.31 plus or minus 0.01 to 0.27 plus or minus 0.00 sec, P smaller than 0.001), but there was no significant change in systolic or diastolic BP or HR. V-cf, EF, and MSER were not singificantly altered by tilt (1.09 plus or minsu 0.04 to 1.12 plus or minus 0.05 circ/sec; 0.70 plus or minus 0.02 to 0.65 plus or minus 0.02; and 2.29 plus or minus 0.07 to 2.43 plus or minus 0.08 end-diastolic volumes/sec, respectively). V-cf, MSER, and EF appearrelatively unaffected by acute alterations in preload. That compensatory sympathetic responses blunted potential changes cannot be excluded, although HR was not found to have increased.
Alterations in coronary artery vascular reactivity of hypertensive Ren-2 transgenic rats.
Authors: M R Tschudi, G Noll, U Arnet, D Novosel, D Ganten, T F Lüscher
Journal: Circulation (1994)

BACKGROUND The renin-angiotensin system and endothelium-derived nitric oxide (EDNO) are important regulators of vascular tone. This study was designed to investigate endothelial and vascular smooth muscle function in coronary arteries of Ren-2 transgenic rats. METHODS AND RESULTS Left anterior descending coronary arteries and aortas were isolated from transgenic rats and Sprague-Dawley control rats at 6 (young) and 12 (adult) weeks of age and examined in myographs or organ chambers for isometric tension recording. Systolic blood pressure was significantly higher in transgenic rats (young, 229 +/- 6 mm Hg; adult, 239 +/- 8 mm Hg) than in control rats (young, 126 +/- 2 mm Hg; adult, 118 +/- 3 mm Hg; P &lt; .005). N omega-Nitro-L-arginine methyl ester (L-NAME, 10(-7) to 10(-4) mol/L) evoked marked endothelium-dependent contractions in coronary arteries (young, 52 +/- 8% of the contraction to 100 mmol/L KCl; adult, 40 +/- 8%) but not aortas (young, 3 +/- 1%; adult, 2 +/- 1%). In coronary arteries, this response was significantly smaller in adult (n = 9) than in young (n = 8, P &lt; .05) control rats. Young transgenic rats (56 +/- 9%, n = 8) showed slightly stronger contractions in response to L-NAME than young control rats (NS), which almost totally disappeared in adult transgenic rats (6 +/- 3%, n = 7; P &lt; .05 versus adult control rats; P &lt; .01 versus young transgenic rats). Endothelium-dependent relaxations in response to acetylcholine (10(-9) to 10(-4) mol/L) were totally blocked by L-NAME (10(-4) mol/L) but were unaffected by the thromboxane receptor antagonist SQ30741 (10(-7) mol/L). This stimulated release of EDNO, endothelium-independent relaxations in response to the nitrovasodilator linsidomine (10(-9) to 10(-5) mol/L), and contractions in response to KCl (100 mmol/L) were comparable in all groups of rats. CONCLUSIONS Ren-2 transgenic rats develop fulminant hypertension that is associated with a selective decrease in endothelium-dependent contractions in response to L-NAME, whereas endothelium-dependent relaxations in response to acetylcholine as well as smooth muscle function remain unaffected.
Oral Vaccine: Associated Paralytic Poliomyelitis, 1962
Authors: Henry M. Gelfand
Journal: JAMA (1963)

UNTIL RECENTLY, there was almost universal agreement that living, attenuated, oral poliovirus vaccine (OPV) composed of the Sabin strains is safe, both to the primary vaccinee and to his contacts. This reputation for safety was won on the basis of the use of OPV in millions of persons in the US and many other countries. Although the thoroughness of routine reporting of morbidity and of special surveillance for possible vaccine-induced cases of paralytic poliomyelitis differed greatly among the various programs, no evidence had been adduced to show that this vaccine, composed of these strains, had ever caused the disease it was designed to prevent. From July through November, 1962, a small number of cases which had followed the use of oral vaccine came to light and they have cast some doubt on the safety of OPV in<i>adult</i>vaccinees. This cluster of cases was intensively studied and discussed in
Open letter to the General Medical Council
Authors: R Wheatley
Journal: BMJ (2007)

Dear Professor Catto

I am writing to you as a designated doctor for child protection. As part of my responsibilities I am required to offer advice and guidance to doctors within my area about child protection matters. Unfortunately, in the light of the recent verdict against Professor David Southall, I feel I cannot fulfil that role responsibly; to do so would put both my and their registration at peril. We urgently need guidance.

I have struggled through the available transcripts of the 33 day hearing which culminated in this judgment. The judgment found that David Southall had inappropriately accused a mother of murdering her 10 year old child. Much of the case hinges on a complaint made by a Mrs “M.” As you are doubtless aware, there have been many such complaints made over the years against Dr Southall, almost all of which are linked to an energetic and committed, but deeply misguided campaign largely run by Penny Mellor. It is perhaps worth noting the commentary on her activities given by Mr Justice Whitburn, in sentencing her to two years imprisonment for her part in the abduction of …
"THE DOCTOR'S DEFENSE"
Authors: V. N. Leonard
Journal: JAMA (1921)

<h3>To the Editor:</h3> —The letter of Dr. F. S. Reilly (The Journal, February 26) with the above title deserves comment because it emphasizes an important objection to group medicine—namely, the danger of cliquism. As Barker has said: "There is nothing, perhaps, more conducive to bad feeling in the profession than the belief that coteries of physicians have set themselves up as superior and exclusive associations that try to monopolize practice. Even when groups are composed of competent, sincere, well bred and fair dealing members, they may excite the envy or the resentment of other groups or of individual practitioners." Dr. Reilly evidently believes that any argument which presents the advantages of group practice is necessarily an attack on the general practitioner. Nothing could be farther from the truth. The opinion I expressed was that the specialist is quite as much in need of the cooperation offered by group methods as
PMO-146 The soluble antagonistic form of IFN-inducible-protein-10 (IP-10) is a predictor of clinical outcome during acute hepatitis C infection
Authors: A Riva, M Laird, A Casrouge, A Ambrozaitis, M Albert, N V Naoumov, S Chokshi
Journal: Gut (2012)

<h3>Introduction</h3> Several immunological parameters have been associated with clinical outcome of HCV infection. We have previously found that acute HCV-infected subjects progressing to chronicity had higher serum IP-10 levels than those who spontaneously resolved the infection, which is counterintuitive given the known pro-inflammatory role of this chemokine. IP-10 is subjected to physiological cleavage of two aminoacids by DPPIV (CD26), which produces an NH<sub>2</sub>-truncated form of the protein. The cleaved form (referred to as short IP-10) antagonises the biologically active longer form by competitively binding to the common receptor without inducing signalling. Most IP-10 assays quantify the total IP-10 protein; however, recently developed assays also allow the distinction of the two forms. The aim of this study was to investigate the role of antagonistic short IP-10 in influencing the clinical outcome of acute HCV infection. <h3>Methods</h3> We analysed 16 patients with acute HCV infection who met the following criteria: ALT&gt;10× upper limit normal (ULN), exposure to HCV within previous 4 months and HCV-RNA(+). Plasma was collected from these patients longitudinally at 12 timepoints. We quantified the long and short forms of IP-10 in these samples. Results were then analysed and correlated with the clinical outcome (chronic vs resolver). The longitudinal nature of the dataset was taken into account through the use of a “mixed model” analytical strategy for repeated measures. <h3>Results</h3> Our investigation confirmed that subjects who progressed to chronicity (n=11) had higher serum concentrations of total IP-10 (p&lt;0.001) compared to patients who resolved spontaneously (n=5). However, these higher amounts of detectable IP-10 were ascribable to increased levels of the antagonistic form (p=0.036), while serum concentrations of biologically active long IP-10 form were comparable with subjects who spontaneously resolved the infection (p=0.460). <h3>Conclusion</h3> This study reports a novel mechanism of chemokine antagonism during acute HCV infection and may represent an additional factor in the failure of the host immune response in eradicating HCV infection. The results also reveal that the short IP-10 is a predictor of clinical outcome after acute HCV infection and may be used to aid treatment decisions during acute HCV infection. <h3>Competing interests</h3> None declared.
Risk stratification–directed donor lymphocyte infusion could reduce relapse of standard-risk acute leukemia patients after allogeneic hematopoietic stem cell transplantation
Authors: Chen-Hua Yan, Dai-Hong Liu, Kai-Yan Liu, Lan-Ping Xu, Yan-Rong Liu, Huan Chen, Wei Han, Yu Wang, Ya-Zhen Qin, Xiao-Jun Huang
Journal: Blood (2012)
Interpersonal Psychotherapy as Augmentation Treatment in Depressed Elderly Responding Poorly to Antidepressant Drugs: A Case Series
Authors: Paolo Scocco, Ellen Frank
Journal: Psychotherapy and Psychosomatics (2002)

&lt;i&gt;Background:&lt;/i&gt; Medication is often the first choice in the treatment of depression, even though large numbers of depressed patients do not respond to antidepressant drugs or fail to achieve symptom remission or recovery. Generally, other drugs, rather than other therapeutic approaches such as psychotherapy, are used as augmentation treatment. This applies in particular to elderly patients. The aim of this work is to assess whether augmentation with interpersonal psychotherapy (IPT) can bring about symptom remission in depressed elderly responding poorly to medication. &lt;i&gt;Method:&lt;/i&gt; Five cognitively intact patients aged over 60 and suffering from major depression were first treated for 6 weeks with a selective serotonin reuptake inhibitor compound. Owing to poor outcome, IPT was added to the treatment. IPT is a brief psychotherapy addressing the interpersonal problems linked to depression, and has been modified for use with elderly patients. &lt;i&gt;Results:&lt;/i&gt; All patients achieved symptom remission after a cycle of psychotherapy lasting a minimum of 16 and a maximum of 20 weekly sessions. &lt;i&gt;Conclusions:&lt;/i&gt; The methodological limitations of this open study do not allow us to generalize from the positive outcomes. Further studies might confirm these initial observations and establish whether an equally satisfactory therapeutic response can be attained if medication is discontinued after the start of psychotherapy.
Laceration of the Stomach During Oxygen Administration by Nasal Catheter
Authors: Arturo Longobardi
Journal: JAMA (1961)

<h3>To the Editor:—</h3> The application of oxygen therapy by insufflation into the oropharynx through a nasal catheter, as originally described by Wineland and Waters (Oxygen Therapy: Insufflation into Oral Pharynx,<i>Arch Surg</i><b>22</b>:67 [Jan.] 1931), is an excellent method but is not without its dangers. This letter is to emphasize the most important danger, which is the possible laceration of the stomach due to sudden distension with oxygen. Such distension is not an uncommon occurrence as a result of the catheter penetrating too deeply and entering the esophagus. Ordinarily this situation is promptly discovered and the catheter is withdrawn without more harm to the patient than minor discomfort. Occasionally, however, such sudden distension can cause laceration of the stomach or lower esophagus with very serious results. Three such instances have recently been reported (Rupture of Normal Stomach After Therapeutic Oxygen Administration,<i>New Engl J Med</i><b>264</b>:1201 [June 8]
Prednisone‐responsive aplastic anemia associated with T‐lymphocyte proliferation
Authors: Sara Bodner, Harvey Jay Cohen
Journal: American Journal of Hematology (1981)

Abstract In some cases, bone marrow aplasia has been thought to result from immunologic abnormalities. Our patient had severe transfusion‐dependent aplastic anemia, which responded to treatment with prednisone on two occasions. The exacerbations of aplastic anemia were associated with lymphocytic proliferation which on one occasion had the characteristics of T‐cell chronic lymphocytic leukemia. Though he had had mild lymphoproliferation for a number of years, he ultimately died with progressive diffuse lymphoid infiltration of the bone marrow and other organs. The simultaneous occurrence of the T‐cell lymphoproliferation and aplastic anemia and their simultaneous response to therapy suggests that this may be a clinical example of T‐lymphocyte mediated suppression of erythropoiesis.
Haptoglobin activates innate immunity to enhance acute transplant rejection in mice
Authors: Hua Shen, Yang Song, Christopher M. Colangelo, Terence Wu, Can Bruce, Gaia Scabia, Anjela Galan, Margherita Maffei, Daniel R. Goldstein
Journal: Journal of Clinical Investigation (2011)

Immune tolerance to transplanted organs is impaired when the innate immune system is activated in response to the tissue necrosis that occurs during harvesting and implantation procedures. A key molecule in this immune pathway is the intracellular TLR signal adaptor known as myeloid differentiation primary response gene 88 (MyD88). After transplantation, MyD88 induces DC maturation as well as the production of inflammatory mediators, such as IL-6 and TNF-α. However, upstream activators of MyD88 function in response to transplantation have not been identified. Here, we show that haptoglobin, an acute phase protein, is an initiator of this MyD88-dependent inflammatory process in a mouse model of skin transplantation. Necrotic lysates from transplanted skin elicited higher inflammatory responses in DCs than did nontransplanted lysates, suggesting DC-mediated responses are triggered by factors released during transplantation. Analysis of transplanted lysates identified haptoglobin as one of the proteins upregulated during transplantation. Expression of donor haptoglobin enhanced the onset of acute skin transplant rejection, whereas haptoglobin-deficient skin grafts showed delayed acute rejection and antidonor T cell priming in a MyD88-dependent graft rejection model. Thus, our results show that haptoglobin release following skin necrosis contributes to accelerated transplant rejection, with potential implications for the development of localized immunosuppressive therapies.
In Utero Diagnosis of Long QT Syndrome by Magnetocardiography
Authors: Bettina F. Cuneo, Janette F. Strasburger, Suhong Yu, Hitoshi Horigome, Takayoshi Hosono, Akihiko Kandori, Ronald T. Wakai
Journal: Circulation (2013)

The electrophysiology of long QT syndrome (LQTS) in utero is virtually unstudied. Our goal here was to evaluate the efficacy of fetal magnetocardiography (fMCG) for diagnosis and prognosis of fetuses at risk of LQTS. We reviewed the pre/postnatal medical records of 30 fetuses referred for fMCG because of a family history of LQTS (n=17); neonatal/childhood sudden cardiac death (n=3), or presentation of prenatal LQTS rhythms (n=12): 2° atrioventricular block, ventricular tachycardia, heart rate < 3(rd) percentile. We evaluated heart rate and reactivity, cardiac time intervals, T-wave characteristics, and initiation/termination of Torsade de Pointes, and compared these with neonatal ECG findings. After birth, subjects were tested for LQTS mutations. Based on accepted clinical criteria, 21 subjects (70%; 9 KCNQ1, 5 KCNH2, 2 SCN5A, 2 other, 3 untested) had LQTS. Using a threshold of corrected QT= 490 ms, fMCG accurately identified LQTS fetuses with 89% (24/27) sensitivity and 89% (8/9) specificity in 36 sessions. Four fetuses (2 KCNH2 and 2 SCN5A), all with corrected QT ≥ 620 ms, had frequent episodes of Torsade de Pointes, which were present 22-79% of the time. Although some episodes initiated with a long-short sequence, most initiations showed QRS aberrancy and a notable lack of pause dependency. T-wave alternans was strongly associated with severe LQTS phenotype. Corrected QT prolongation (≥490 ms) assessed by fMCG accurately identified LQTS in utero; extreme corrected QT prolongation (≥620 ms) predicted Torsade de Pointes. FMCG can play a critical role in the diagnosis and management of fetuses at risk of LQTS.