Disseminated Aspergillosis Mimicking Hepatic Veno-Occlusive Disease
Authors: George L. Daikos, Vassiliki Syriopoulou, George Aperis, Christos Toubanakis, George Petrikkos, Maria Demonakos
Journal: Annals of Internal Medicine (2005)

Letters16 August 2005Disseminated Aspergillosis Mimicking Hepatic Veno-Occlusive DiseaseGeorge L. Daikos, Vassiliki Syriopoulou, George Aperis, Christos Toubanakis, George Petrikkos, and Maria DemonakosGeorge L. DaikosFrom University of Athens, 115-27 Athens, Greece, and Sismonoglion General Hospital, 151-26 Athens, Greece.Search for more papers by this author, Vassiliki SyriopoulouFrom University of Athens, 115-27 Athens, Greece, and Sismonoglion General Hospital, 151-26 Athens, Greece.Search for more papers by this author, George AperisFrom University of Athens, 115-27 Athens, Greece, and Sismonoglion General Hospital, 151-26 Athens, Greece.Search for more papers by this author, Christos ToubanakisFrom University of Athens, 115-27 Athens, Greece, and Sismonoglion General Hospital, 151-26 Athens, Greece.Search for more papers by this author, George PetrikkosFrom University of Athens, 115-27 Athens, Greece, and Sismonoglion General Hospital, 151-26 Athens, Greece.Search for more papers by this author, and Maria DemonakosFrom University of Athens, 115-27 Athens, Greece, and Sismonoglion General Hospital, 151-26 Athens, Greece.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-143-4-200508160-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Background: The incidence of invasive aspergillosis is increasing in parallel with the number of immunosuppressed patients (1). Although Aspergillus is not known as a pathogen with liver tropism, 11% of patients who die of or with invasive aspergillosis have liver involvement (2). The clinical patterns of hepatic aspergillosis vary and depend on the extent of invasion and the anatomic site of the liver involved. To our knowledge, invasion of sinusoids by fungal hyphae resulting in a syndrome mimicking hepatic veno-occlusive disease has not been previously reported.Case Report: A 53-year-old woman was admitted to our hospital with ...References1. Denning DW. Invasive aspergillosis. Clin Infect Dis. 1998;26:781-803. [PMID: 9564455] CrossrefMedlineGoogle Scholar2. Young RC, Bennett JE, Vogel CL, Carbone PP, DeVita VT. Aspergillosis. The spectrum of the disease in 98 patients. Medicine (Baltimore). 1970;49:147-73. [PMID: 4913991] CrossrefMedlineGoogle Scholar3. Smith DK, Neal JJ, Holmberg SD. Unexplained opportunistic infections and CD4+ T-lymphocytopenia without HIV infection. An investigation of cases in the United States. The Centers for Disease Control Idiopathic CD4+ T-lymphocytopenia Task Force. N Engl J Med. 1993;328:373-9. [PMID: 8093633] CrossrefMedlineGoogle Scholar4. Young RC. The Budd-Chiari syndrome caused by Aspergillus; two patients with vascular invasion of the hepatic veins. Arch Intern Med. 1969;124:754-7. [PMID: 5353485] CrossrefMedlineGoogle Scholar5. Wadleigh M, Ho V, Momtaz P, Richardson P. Hepatic veno-occlusive disease: pathogenesis, diagnosis and treatment. Curr Opin Hematol. 2003;10:451-62. [PMID: 14564177] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: George L. Daikos; Vassiliki Syriopoulou; George Aperis; Christos Toubanakis; George Petrikkos; Maria DemonakosAffiliations: From University of Athens, 115-27 Athens, Greece, and Sismonoglion General Hospital, 151-26 Athens, Greece.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byConsensus Report by the Pediatric Acute Lung Injury and Sepsis Investigators and Pediatric Blood and Marrow Transplantation Consortium Joint Working Committees on Supportive Care Guidelines for Management of Veno-Occlusive Disease in Children and Adolescents, Part 3: Focus on Cardiorespiratory Dysfunction, Infections, Liver Dysfunction, and DeliriumHepatic Mucormycosis Mimicking Veno-Occlusive Disease: Report of a Case and Review of the LiteratureHost immune defense against Aspergillus fumigatus: insight from experimental systemic (disseminated) infectionExperimental disseminated aspergillosis in mice: Histopathological study 16 August 2005Volume 143, Issue 4Page: 315-316KeywordsAbscessesAmphotericinAscitesAspergillosisBiopsyComputed axial tomographyLiverResearch laboratoriesThoraxVeins ePublished: 16 August 2005 Issue Published: 16 August 2005 Copyright & PermissionsCopyright © 2005 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...