tbuckley/cabot-search huggingface dataset:
Mapping the gene causing X-linked recessive nephrolithiasis to Xp11.22 by linkage studies.
Authors: S J Scheinman, M A Pook, C Wooding, J T Pang, P A Frymoyer, R V Thakker
Journal: Journal of Clinical Investigation (1993)

X-linked recessive nephrolithiasis is associated with kidney stones and renal tubular dysfunction in childhood progressing to renal failure in adulthood.The primary defect causing this renal tubular disorder is unknown and determining the chromo- somal location of the mutant gene would represent an important step toward defining the biochemical basis.We have performed linkage studies in 102 members (10 affected males, 47 unaffected males, 15 obligate heterozygote females, and 30 unaffected females) from five generations of one family.As genetic markers we used 10 cloned human X chromosome fragments identifying restriction fragment length polymorphisms and seven pairs of oligonucleotide primers identifying microsatel- lite polymorphisms.Linkage with the locus DXS255 was es- tablished with a peak LOD score = 5.91 at 3.6% recombination, thereby localizing the X-linked recessive nephrolithiasis gene to the pericentromeric region of the short arm of the X chromosome (Xpl 1.22).Multilocus analysis indicated that the mutant gene was distal to DXS255 but proximal to the Duchenne muscular dystrophy locus on Xp.Thus, the gene that causes X-linked recessive nephrolithiasis maps to the pericen- tromeric region of the short arm of the X chromosome (Xpll.22),and further characterization of this gene will help to elucidate the factors controlling renal tubular function and mineral homeostasis. (
Hormone Resistance and Hormone Sensitivity
Authors: Jesse Roth, David M. Neville, C. Ronald Kahn, Phillip Gorden
Journal: New England Journal of Medicine (1977)

ON casual inspection the study by Oseid et al., "Decreased Binding of Insulin to Its Receptor in Patients with Congenital Generalized Lipodystrophy," appears to concern a single unusual metabolic disorder. In fact, this work adds directly to emerging concepts about disorders of insulin sensitivity, including rare ones associated with lipodystrophy or acanthosis nigricans and common ones such as obesity and diabetes1 2 3 4 5 6 (also references cited by Oseid and his colleagues). Moreover, these concepts apply beyond insulin to other hormones and to other regulatory systems that use intercellular humoral signals as diverse in character as neurotransmitters, immunoglobulins and cholesterol-containing serum lipoproteins.6 7 8 9 Recent . . .
Would the NHS benefit from a single, identifiable leader? An email conversation
Authors: D. Berwick
Journal: BMJ (2003)

<h3>Abstract</h3> Nucleoporins (Nups) form the selective permeability barrier that separates the nucleoplasm from the cytoplasm. In addition to their localization at the nuclear envelope, Nups have been observed in cytoplasmic foci in many cell types. We have investigated the origin of Nup foci using <i>C. elegans</i> oocytes, which naturally accumulate high concentrations of Nups. We find that the foci derive from condensation of highly cohesive FG-Nups, which are maintained at concentrations right above the solubility limit in oocytes. Nup solubility is enhanced by chaperone activity and posttranslational modifications that also promote nuclear pore channel fluidity and pore disassembly during mitosis. Oocyte Nup foci dissolve during M phase and are not essential for embryonic viability. Overexpression of the highly cohesive FG-Nup, Nup98, in post-mitotic neurons leads to uncontrolled Nup aggregation and organismal paralysis, underscoring the importance of mechanisms that maintain Nup solubility in the cytoplasm.
1019 GLUCOCORTICOID-INDUCED LEUCINE ZIPPER: A KEY PROTEIN IN THE SENSITIZATION OF MONOCYTES TO LIPOPOLYSACCHARIDE IN ALCOHOLIC HEPATITIS
Authors: H. Hamdi, A.-M. Cassard-Doulcier, A. Bigorgne, A. Balian, L. Bouchet-Delbos, M.-C. Maillot, I. Durand-Gasselin, S. Prévot, J. Delaveaucoupet, D. Emilie, S. Naveau, G. Perlemuter
Journal: Journal of Hepatology (2009)
Berberine Modifies Cysteine 179 of IκBα Kinase, Suppresses Nuclear Factor-κB–Regulated Antiapoptotic Gene Products, and Potentiates Apoptosis
Authors: Manoj K. Pandey, Bokyung Sung, Ajaikumar B. Kunnumakkara, Gautam Sethi, Madan M. Chaturvedi, Bharat B. Aggarwal
Journal: Cancer Research (2008)

Abstract Berberine, an isoquinoline alkaloid derived from a plant used traditionally in Chinese and Ayurvedic medicine, has been reported to exhibit chemopreventive and anti-inflammatory activities through unknown mechanism. Because of the critical role of the transcription factor nuclear factor-κB (NF-κB) in these processes, we investigated the effect of berberine on this pathway. We found that berberine suppressed NF-κB activation induced by various inflammatory agents and carcinogens. This alkaloid also suppressed constitutive NF-κB activation found in certain tumor cells. Suppression of NF-κB activation occurred through the inhibition of phosphorylation and degradation of IκBα by the inhibition of IκB kinase (IKK) activation, leading to suppression of phosphorylation and nuclear translocation of p65, and finally to inhibition of NF-κB reporter activity. Inhibition of IKK by berbeine was direct and could be reversed by reducing agents. Site-specific mutagenesis suggested the involvement of cysteine residue 179 in IKK. Berberine also suppressed the expression of NF-κB–regulated gene products involved in antiapoptosis (Bcl-xL, Survivin, IAP1, IAP2, and cFLIP), proliferation (cyclin D1), inflammation (cyclooxygenase-2), and invasion (matrix metalloproteinase-9). Suppression of antiapoptotic gene products correlated with enhancement of apoptosis induced by tumor necrosis factor (TNF)-α and chemotherapeutic agents and with inhibition of TNF-induced cellular invasion. Overall, our results indicate that chemopreventive, apoptotic, and anti-inflammatory activities displayed by berberine may be mediated in part through the suppression of the NF-κB activation pathway. This may provide the molecular basis for the ability of berberine to act as an anticancer and anti-inflammatory agent. [Cancer Res 2008;68(13):5370–9]
Breast Cancer and the Use of Oral Contraceptives
Authors: H. M. Lemon, H. T. Lynch
Journal: JAMA (1986)

<h3>To the Editor.—</h3> The report of Lipnick et al<sup>1</sup>on breast cancer incidence and contraceptive use in 70 151 premenopausal nurses showed that the majority of younger women (aged &lt;39 years) with cancer had used contraceptives. Age-specific annual breast cancer incidence calculated from their Table 4 was significantly increased in these age groups, compared with US white females reported by the National Cancer Institute<sup>2</sup>(Table). In such a large population sample, one might expect that some of the confounding variables that increase the risk of breast cancer, such as genetic predisposition orbenign breast disease, would not have undergone positive selection bias. In another recent report using the same data base, Pathak et al<sup>3</sup>found that low parity increased the risk of breast cancer compared with nulliparous nurses; with increasing parity of three or more pregnancies (nurses aged &gt;39 years), the risks became similar for the childless
Dangerous Delays in Tampon Absorbency Warnings
Authors: Sidney M. Wolfe
Journal: JAMA (1987)

The Centers for Disease Control (CDC) study in this issue ofThe Journalconfirms the strong association between increased tampon absorbency and enhanced risk of toxic shock syndrome (TSS)<sup>1</sup>and again highlights, as seen with aspirin and Reye's syndrome,<sup>2</sup>the dangerous delay between scientific knowledge and its conversion into public policy. The failure of the Food and Drug Administration (FDA) to warn women adequately based on evidence available more than six years ago, a failure prolonged by the tampon industry, has caused unnecessary risks to millions of American women who regularly use tampons. Since early 1981, when the FDA was first informed by Minnesota Health Department epidemiologist Michael Osterholm, PhD, MPH, of the results of the Tri-State Study, which concluded that "women who used high absorbency tampons had a greater relative risk of developing TSS than women who used low absorbency tampons,"<sup>3</sup>there have been 1584 reported
Trial by Fire: First Medical Board Certification in Iraq
Authors: Raymond B. Bedgood
Journal: Annals of Internal Medicine (2009)

On Being a Doctor3 March 2009Trial by Fire: First Medical Board Certification in IraqRaymond B. Bedgood, LTC, MCRaymond B. Bedgood, LTC, MCFrom Gastroenterology Associates of Central Georgia, Macon, GA 31210.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-150-5-200903030-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail 9 January 2008To: Chief Surgeon for the Army National Guard, Col. David SproatFrom: Senior Clinical Physician, LTC Raymond B. Bedgood, 213th ASMC, Tallil AB, IraqSubject: After Action Review for First Medical Board Certification in IraqI am a National Guard physician and I happened to finish my gastroenterology/hepatology fellowship on 30 June 2007. I planned to take my board certification test in October 2007, but I knew of my upcoming deployment in Iraq at that time.I had begun arranging to take my gastroenterology boards in January 2007. I called my liaison, who was arranging my scheduled ... Author, Article, and Disclosure InformationAffiliations: From Gastroenterology Associates of Central Georgia, Macon, GA 31210.Corresponding Author: Raymond B. Bedgood, LTC, MC, Gastroenterology Associates of Central Georgia, 420 Charter Boulevard, Suite 205, Macon, GA 31210; e-mail, raymond.[email protected]army.mil. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Professional Testing Center: Past and Present Christine K. Cassel Metrics Cited byThe Professional Testing Center: Past and PresentChristine K. Cassel, MD 3 March 2009Volume 150, Issue 5Page: 355-356KeywordsAtaxiaComputersCyclic adenosine monophosphateEatingFellowshipsForecastingGastroenterology and hepatologyRunningSleepSurgeons ePublished: 3 March 2009 Issue Published: 3 March 2009 Copyright & PermissionsCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Vaginal Birth After Cesarean Delivery
Authors: W. Benson Harer, Jr
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prevention of Endotracheal Suctioning-induced Alveolar Derecruitment in Acute Lung Injury
Authors: Salvatore M. Maggiore, François Lellouche, Jérôme Pigeot, Solenne Taille, Nicolas Deye, Xavier Durrmeyer, Jean-Christophe Richard, Jordi Mancebo, François Lemaire, Laurent Brochard
Journal: American Journal of Respiratory and Critical Care Medicine (2003)

We studied endotracheal suctioning-induced alveolar derecruitment and its prevention in nine patients with acute lung injury. Changes in end-expiratory lung volume measured by inductive plethysmography, positive end-expiratory pressure-induced alveolar recruitment assessed by pressure–volume curves, oxygen saturation, and respiratory mechanics were recorded. Suctioning was performed after disconnection from the ventilator, through the swivel adapter of the catheter mount, with a closed system, and with the two latter techniques while performing recruitment maneuvers during suctioning (40 cm H2O pressure-supported breaths). End-expiratory lung volume after disconnection fell more than with all other techniques (−1,466 ± 586, −733 ± 406, −531 ± 228, −168 ± 176, and −284 ± 317 ml after disconnection, through the swivel adapter, with the closed system, and with the two latter techniques with pressure-supported breaths, respectively, p < 0.001), and was not fully recovered 1 minute after suctioning. Recruitment decreased after disconnection and using the swivel adapter (−104 ± 31 and −63 ± 25 ml, respectively), was unchanged with the closed system (−1 ± 10 ml), and increased when performing recruitment maneuvers during suctioning (71 ± 37 and 60 ± 30 ml) (p < 0.001). Changes in alveolar recruitment correlated with changes in lung volume (ρ = 0.88, p < 0.001) and compliance (ρ = 0.9, p < 0.001). Oxygenation paralleled lung volume changes. Suctioning-induced lung derecruitment in acute lung injury can be prevented by performing recruitment maneuvers during suctioning and minimized by avoiding disconnection.
Enteritis and Polyarthritis following Partial Gastrectomy
Authors: J. H. Shoesmith, H. S. Shucksmith
Journal: BMJ (1956)

MEDICAL JOURNAlSmall portions were cut from the anterior tibial and peroneal muscles.The skin was sutured over the open fascia.A plaster back slab was applied for a week.After operation the pain in the leg was dramatically relieved.Movements of the foot improved during the fol- lowing week, extension of the great toe being the last to recover.The wound healed slowly, with some sloughing of its edges.The patient was discharged on August 25, and when ex- amined a month later had no symptoms referable to his leg.Recovery of muscle power was complete except for some persistent weakness of the extensor hallucis longus.The muscle fragments showed, in the case of tibialis anterior, interstitial oedema and leucocytic infiltration with extensive degeneration and early necrosis of muscle fibres.The control specimen from the peronei showed only some fatty infiltration.The delay in the healing of the operation wound, which might be more serious in a limb with a greater degree of ischaemia, suggests that a case can be made for performing decompressions of this sort through a small incision, using Gallie's fasciotome.
IMG (International Medical Graduate)
Authors: Bhuvana Chandra
Journal: Annals of Internal Medicine (1998)

Ad Libitum1 December 1998IMG (International Medical Graduate)Bhuvana Chandra, MDBhuvana Chandra, MDNorthridge, CA 91326Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-129-11_Part_1-199812010-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IIn Madras, threadworms crawl out at nighton hospital sheets glazed dun with washing.They wriggle in the middleof rumpled starch-stained cotton,barely visible punctuationsto unread chapters of overwritten lives.Morning light discovers old men furledfever-heated, anopheles-shivered,in bedless pockets of a gorged ward;dreaming a womb's caress of the cold stone floor,warmed by thoughts of noonand the trays with lentil soup.At three in the humid afternoon,the Injection O.P. is full. A curving brown ribbontwirls out its double doors;goose-stepped rows of nude upper arms,sacrificial lambs bereft of all fat,... Author, Article, and Disclosure InformationAuthors: Bhuvana Chandra, MDAffiliations: Northridge, CA 91326Corresponding Author: Bhuvana Chandra, MD, PO Box 7694, Northridge, CA 91327. Previousarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1998Volume 129, Issue 11_Part_1 Page: 911-912 Keywords Lungs Multiple sclerosis Myocardial infarction Nursing homes Parasitology Sleep Thorax Tongue Ulcers Veins ePublished: 15 August 2000 Issue Published: 1 December 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Metastatic Crohn's disease responding to metronidazole
Authors: P. DUHRA, C.J. PAUL
Journal: British Journal of Dermatology (1988)

Metastatic Crohn's disease is a rare cutaneous manifestation of intestinal Crohn's disease, for which existing treatment is unsatisfactory. We report a case of perianal and vulval Crohn's disease which cleared completely on a 4-month course of metronidazole without adverse effects. The patient remained in remission I year later. The merits of long-term treatment with metronidazole are discussed.
Limited Lentiviral Transgene Expression with Increasing Copy Number in an MGMT Selection Model: Lack of Copy Number Selection by Drug Treatment
Authors: Steven P Zielske, Karen T Lingas, Yan Li, Stanton L Gerson
Journal: Molecular Therapy (2004)

Retroviral vector integration into the human genome carries increased risk of oncogenesis with increasing integrations. To boost transgene expression for gene therapy, multiple integrations are often sought. We studied the relationship between the number of vector integrations and transgene expression and the effect that drug selection in an MGMT-selection model would have on vector copy number. K562 cells were transduced using a lentiviral vector and a library of clones was generated. Median proviral copy number was 4 and a positive correlation with transgene expression was observed. Transgene expression increased at a linear rate between 1 and 4 vector copies/cell, but was unpredictable at >4 integrations/cell. When lentivirus MGMT(P140K)-transduced K562 cells were treated with O(6)-benzylguanine (BG)/BCNU, there was no selection for increased median copy number in colony-forming units, despite strong selection pressure and an increase in transgene expression and activity. These data show a direct and linear correlation between MGMT(P140K) transgene expression and vector copy number. Strong BG/BCNU selective pressure does not result in preferential survival of high-copy-number clones but does select for strong transgene expression. Thus drug selection would not be expected to increase the risk of oncogenesis due to exaggerated selection in favor of high-copy-number vector integration.
Capillary permeability of 131I-albumin in the resting human forearm
Authors: W. P Paaske, O. Henriksen, P. Sejrsen
Journal: Cardiovascular Research (1990)

The aim was to examine capillary permeability of 131I-albumin in the normal, resting human forearm.A bolus injection of 131I-albumin was injected into the brachial artery, and the residue function was measured by external registration over the forearm tissues. The results were analysed by indicator kinetic "black box" theory using the single injection, residue detection method which is based on indicator diffusion principles.Seven normal volunteers participated in the study.The mean capillary extraction fraction of 131I-albumin was 0.023 (SD 0.0056), n = 7, at a mean plasma flow rate of 2.1 (0.34) ml.100 g-1.min-1. At an estimated capillary surface area of 70 cm.g-1 the permeability coefficient was 11.10(-8) cm.s-1.According to the theories of restricted diffusion and equivalent pores the results are compatible with an equivalent pore radius estimate of 113 A using additional previously published results from experiments with 51Cr-EDTA.
Undergraduate Medical Education
Authors: H S Jonas, S I Etzel, B Barzansky
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Insulin Receptor: Structure and Function
Authors: STEVEN JACOBS, PEDRO CUATRECASAS
Journal: Endocrine Reviews (1981)

INSULIN receptor has been purified by affinity chromatography and studied by affinity labeling techniques. It is composed of two types of subunits, α (molecular weight ∼135,000) and β (molecular weight α90,000), which form a disulfide-linked heterotetramer (αβ)2. Both α- and β-subunits are glycoproteins. Both are exposed on the outer surface of the membrane, a is the subunit that is predominantly affinity labeled by insulin and is probably the insulin-binding subunit; however, β may also comprise a portion of the insulin-binding site. Receptors for insulin-like growth factors have also been affinity labeled. A photoaffinity labeling derivative of basic somatomedin affinity labels a protein with a subunit structure very similar to the insulin receptor. In contrast, multiplication-stimulating activity is affinity cross-linked to a protein with an entirely different subunit structure. After binding to cell surface receptors, insulin, along with its receptor, is internalized by an endocytic process, which in some cells involves coated pits.
Bleeding in a Patient Receiving Warfarin and Ketoprofen
Authors: Frederick S. Wilson
Journal: JAMA (1988)

To the Editor.  —In a recent letter, Drs Flessner and Knight reported a patient who developed prolongation of the prothrombin time and gastrointestinal tract bleeding associated with concomitant use of warfarin sodium and ketoprofen. 1 The authors noted that this was a new observation.  In the prescribing information on  (ketoprofen), Wyeth Laboratories, Philadelphia, discusses the possible occurrence of this side effect. Although a short-term, controlled study of 14 normal volunteers showed no interference by  use in the effect of warfarin therapy on prothrombin time, we warn, Bleeding from a number of sites may be a complication of warfarin treatment and GI [gastrointestinal] bleeding a complication of  treatment. Because prostaglandins play an important role in hemostasis and ketoprofen has an effect on platelet function as well, concurrent therapy with  and warfarin requires close monitoring of patients on both drugs.  We further state, Orudis decreases platelet adhesion and