Thrombocytopenia, the Acquired Immunodeficiency Syndrome (AIDS), and Zidovudine
Authors: Patrice Viens
Journal: Annals of Internal Medicine (1988)

Letters and Corrections15 October 1988Thrombocytopenia, the Acquired Immunodeficiency Syndrome (AIDS), and ZidovudinePatrice Viens, MD, Antoine Thyss, MD, Georges Garnier, MD, Philippe Ayela, MDPatrice Viens, MDSearch for more papers by this author, Antoine Thyss, MDSearch for more papers by this author, Georges Garnier, MDSearch for more papers by this author, Philippe Ayela, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-8-681_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: Thrombocytopenia related to the acquired immunodeficiency syndrome (AIDS) is a frequent problem, the cause and treatment of which are not well established. We report such a case of thrombocytopenia in a patient who showed dramatic improvement with zidovudine therapy.In October 1983, a 22-year-old homosexual man had generalized lymphadenopathy; antibodies to the human immunodeficiency virus (HIV) were present and the CD4:CD8 ratio was 0.50. The patient's physical condition remained stable from October 1983 to March 1987, and his platelet count ranged from 100 × 109/L and 150 × 109/L.The patient was finally diagnosed as having AIDS...References1. AbramsKiprovGoedertSarngadharanGalloVolberding DDJMRP. Antibodies to human T-lymphocytic virus type III and development of the acquired immunodeficiency syndrome in homosexual men presenting with immune thrombocytopenia. Ann Intern Med. 1986;104:47-50. LinkGoogle Scholar2. WalshKrigelLennetteKarpatkin CRES. Thrombocytopenia in homosexual patients: prognosis, response to therapy, and prevalence of antibody to the retrovirus associated with the AIDS. Ann Intern Med. 1985;103:542-5. LinkGoogle Scholar3. CostelloTreacyLai CML. Treatment of immune thrombocytopenic purpura in homosexual men. Scand J Haematol. 1986;36:507-10. CrossrefMedlineGoogle Scholar4. SalamaMueller-EckhardtKiefel ACV. Effect of intravenous immunoglobulin in immune thrombocytopenia: competitive inhibition of reticuloendothelial system function by sequestration of autologous red blood cells. Lancet. 1983;1:193-5. CrossrefGoogle Scholar5. GottliebWolfeChafey MPS. Case report: response of AIDS-related thrombocytopenia to intravenous and oral azidothymidine (3′-azido-3′-deoxythymidine). AIDS Res Human Retroviruses. 1987;3:109-14. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Patrice Viens, MD; Antoine Thyss, MD; Georges Garnier, MD; Philippe Ayela, MDAffiliations: Centre Antoine-Lacassagne Nice, 06054, France PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTissue clearing and 3D reconstruction of digitized, serially sectioned slides provide novel insights into pancreatic cancerEfficacité de l'azidothymidine sur la thrombopénie associée à l'infection par le virus HIV 15 October 1988Volume 109, Issue 8Page: 681-681KeywordsAIDSAntibodiesHIVHomosexualsPlatelets ePublished: 1 December 2008 Issue Published: 15 October 1988 PDF downloadLoading ...