Auto-immune Hemolytic Anemia Treated with d-Penicillamine
Authors: C. LOWELL EDWARDS
Journal: Annals of Internal Medicine (1965)

Case Studies1 March 1965Auto-immune Hemolytic Anemia Treated with d-PenicillamineReport of a CaseC. LOWELL EDWARDS, M.D., NAZARETH GENGOZIAN, PH.D.C. LOWELL EDWARDS, M.D.Search for more papers by this author, NAZARETH GENGOZIAN, PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-3-576 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMacroglobulins are a group of serum proteins, frequently referred to as paraproteins, having a molecular weight of at least one million and a sedimentation constant of more than 15 (usually 19 to 20) Svedberg units. Among the macroglobulins of clinical importance are the macroglobulin of Waldenström, the rheumatoid factor, some isohemagglutinins and Rh antibodies, some cryoglobulins, and cold agglutinins. In 1957, Deutsch and Morton (1) reported that macroglobulins could be depolymerized in vitro by incubation with certain mercaptans. It was later demonstrated that upon depolymerization the physiologic or immunologic properties of the proteins were lost even when there was some...References1. DEUTSCHMORTON HFJI: Dissociation of human serum macroglobulins. Science 125: 600, 1957. CrossrefMedlineGoogle Scholar2. WALSHE FM: Penicillamine, a new oral therapy for Wilson's disease. Amer. J. Med. 21: 487, 1956. CrossrefMedlineGoogle Scholar3. BLOCHPRASADANASTASIBRIGGS HSAADR: Serum protein changes in Waldenström's macroglobulinemia during administration of a low molecular weight thiol (penicillamine). J. Lab. Clin. Med. 56: 212, 1960. Google Scholar4. RITZMANNLEVIN SEWC: Effect of mercaptanes in cold agglutinin disease. J. Lab. Clin. Med. 57: 718, 1961. MedlineGoogle Scholar5. JAFFE IA: Comparison of the effect of plasmapheresis and penicillamine on the level of circulating rheumatoid factor. Ann. Rheum. Dis. 22: 71, 1963. CrossrefMedlineGoogle Scholar6. KUCHINSKASDU VIGNEAUD EJV: An increased vitamin B6 requirement in the rat on a diet containing L-penicillamine. Arch. Biochem. 66: 1, 1957. CrossrefMedlineGoogle Scholar7. FISHERSCHEWE BE: Further observations on skin homografts in pyridoxine deficient animals. Ann. Surg. 155: 457, 1962. CrossrefMedlineGoogle Scholar8. TOBINALTMAN MSK: Accelerated immune response induced by D-L penicillamine. Proc. Soc. Exp. Biol. Med. 115: 25, 1964. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: C. LOWELL EDWARDS, M.D.; NAZARETH GENGOZIAN, PH.D.Affiliations: Oak Ridge, TennesseeFrom the Medical Division, Oak Ridge Institute of Nuclear Studies, Oak Ridge, Tenn., under contract with the United States Atomic Energy Commission.Requests for reprints should be addressed to Dr. Nazareth Gengozian, Medical Division, Oak Ridge Institute of Nuclear Studies, P. O. Box 117, Oak Ridge, Tenn. 37831. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEvans' syndrome as a presenting manifestation of atypical paroxysmal cold hemoglobinuriaUntersuchungen zur immunsuppressiven Wirkung von D-PenicillaminThe treatment of rheumatoid arthritis and necrotizing vasculitis with penicillamineEffect of increased serum sulphydryl content on titre of rheumatoid factor.Excretion of Trace Elements in Two Penicillamine-treated Cases of CystinuriaAntipyridoxine Effect of d-Penicillamine in Schizophrenic MenPenicillamine Therapy for Rheumatoid Lung Disease: Effects on Protein Sulphydryl GroupsThe effect of penicillamine on the laboratory parameters in rheumatoid arthritis 1 March 1965Volume 62, Issue 3Page: 576-579KeywordsAgglutininsAntibodiesCorticosteroid therapyHemolytic anemiaProteinsSerum proteins ePublished: 1 December 2008 Issue Published: 1 March 1965 PDF downloadLoading ...