Salivary Gland Enlargement Caused by Sulfisoxazole
Authors: BERNARD D. NIDUS
Journal: Annals of Internal Medicine (1965)

Case Studies1 October 1965Salivary Gland Enlargement Caused by SulfisoxazoleBERNARD D. NIDUS, M.D., MICHAEL FIELD, M.D., CHARLES H. RAMMELKAMP JR., M.D.BERNARD D. NIDUS, M.D.Search for more papers by this author, MICHAEL FIELD, M.D.Search for more papers by this author, CHARLES H. RAMMELKAMP JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-4-663 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA wide variety of toxic and allergic reactions have been associated with the administration of sulphonamides (1). A recent patient was observed who developed salivary gland enlargement on four separate occasions after the administration of sulfisoxazole; to our knowledge this reaction to a sulphonamide has not been reported previously.CASE REPORTA 72-year-old Negro female was admitted to the hospital after collapsing at home. Neurological examination (on this admission) revealed rightsided weakness, a right extensor plantar sign, mild confusion, dysarthria, and a left homonymous hemianopsia. The blood pressure was 160/100 mm Hg; the remainder of the physical exam was within...References1. WEINSTEINMADOFFSAMET LMACM: Medical progress: the sulfonamides. New Eng. J. Med. 263: 952, 1960. CrossrefMedlineGoogle Scholar2. BOCKUSRAFFENSPERGER HLEC: Acute pancreatitis. New York J. Med. 48: 2252, 1948. MedlineGoogle Scholar3. BARRETTHIER PVSO: Meningitis and pancreatitis associated with sulfamethizole. New Eng. J. Med. 268: 36, 1963. CrossrefMedlineGoogle Scholar4. MERKELCRAWFORD WCRC: Pathological lesions produced by sulfathiazole. JAMA 119: 770, 1942. CrossrefGoogle Scholar5. WARRENMCDONALD KWWM: Acute and chronic pancreatitis. Ann. Rev. Med. 15: 335, 1964. CrossrefMedlineGoogle Scholar6. PEARSON RS: Recurrent swellings of the parotid gland. Gut 2: 210, 1961. CrossrefMedlineGoogle Scholar7. WALDBOTTSHEA GLJJ: Allergic parotitis. J. Allerg. 18: 51, 1947. CrossrefMedlineGoogle Scholar8. PETER TA: Bronchography in iodine sensitivity. JAMA 148: 1419, 1952. CrossrefMedlineGoogle Scholar9. CARTER JE: Iodide "mumps." New Eng. J. Med. 264: 987, 1961. CrossrefMedlineGoogle Scholar10. BORSANYI SJ: Chronic asymptomatic enlargement of the parotid gland. Ann. Otol. 71: 857, 1962. Google Scholar11. CHODIRKERTOMASI WBTB: Gammaglobulins: quantitative relationships in human serum and nonvascular fluids. Science 142: 1080, 1963. CrossrefMedlineGoogle Scholar12. FIREMANVANNIERGOODMAN PWEHC: The association of skin sensitivity with the B2A globulin in sera from ragweed sensitive patients. J. Exp. Med. 117: 603, 1963. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: BERNARD D. NIDUS, M.D.; MICHAEL FIELD, M.D.; CHARLES H. RAMMELKAMPJR., M.D.Affiliations: Cleveland, OhioFrom the Department of Medicine, Cleveland Metropolitan General Hospital, Western Reserve University School of Medicine, Cleveland, Ohio.This study was supported by service trainee grant TI-HE-5507 from the U. S. Public Health Service, Bethesda, Md.Requests for reprints should be addressed to Charles H. Rammelkamp, Jr., M.D., Cleveland Metropolitan General Hospital, 3395 Scranton Rd., Cleveland, Ohio 44109. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySulfonamidesANTIBACTERIAL DRUGSSulfonamidesAdverse drug reactions in the mouthBibliographyJuvenile recurrent parotitis: Clinicoradiologic follow-up study and the beneficial effect of sialographyDrug-induced pancreatitis: A critical reviewPancreatitis as an Adverse Reaction to Salicylazosulfapyridine 1 October 1965Volume 63, Issue 4Page: 663-665KeywordsAllergy and immunologyBlood pressureHospital medicineMedical servicesPancreatitisSalivary glands ePublished: 1 December 2008 Issue Published: 1 October 1965 PDF downloadLoading ...