Gentamicin and Kanamycin Nomograms
Authors: ROGER W. JELLIFFE
Journal: Annals of Internal Medicine (1972)

Letters, Comments, and Corrections1 September 1972Gentamicin and Kanamycin NomogramsROGER W. JELLIFFE, M.D., DANIEL IVLER, PH.D.ROGER W. JELLIFFE, M.D.Search for more papers by this author, DANIEL IVLER, PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-77-3-480 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The article by Chan, Benner, and Hoeprich, describing their nomogram for gentamicin dosage in patients with renal insufficiency ( 1 ), was read with interest. Their nomogram is useful, and the data seem to be solid. Their discussion, however, might have been enhanced by a more complete reference to similar work done by others. For example, probably the first description of the relationship between the kinetic properties of drugs and proper dosage regimens was done by Augsberger for cardiac glycosides (2). This approach was refined and extended by the late Ekkehard Kruger-Thiemer into a formal theory of...References1. CHAN R, BENNER E, and HOEPRICH P: Gentamicin therapy in renal failure: a nomogram for dosage. Ann Intern Med 76:773-778, 1972 LinkGoogle Scholar2. AUGSBERGER A: Quantitatives zur Therapie mit Herzglycosiden. Klin Wochenschr 32:945, 1954 CrossrefMedlineGoogle Scholar3. KRUGER-THIEMER E: Formal theory of drug dosage regimens. J Theor Biol 13:212, 1966 CrossrefGoogle Scholar4. VAN ROSSUM J: Pharmacokinetics of accumulation. J Pharm Sci 57:2162-2164, 1968 CrossrefMedlineGoogle Scholar5. DEFARES J and SNEDDON I: The Mathematics of Medicine and Biology. Chicago, Year Book Medical Publisher, Inc., 1961, pp. 255-259 Google Scholar6. JELLIFFE R: An improved method of digoxin therapy. Ann Intern Med 69:703-717, 1968 LinkGoogle Scholar7. JELLIFFE R, BUELL J, and KALABA R: An improved method of digitoxin therapy. Ann Intern Med 72:453-464, 1970 LinkGoogle Scholar8. JELLIFFE R, BUELL J, and KALABA R: A computer program for digitalis dosage regimens. Mathematical Biosci 9:179-193, 1970 CrossrefGoogle Scholar9. MAWER G, KNOWLES B, and LUCAS S: Computer-assisted prescribing of kanamycin for patients with renal insufficiency. Lancet 1:12-15, 1972 CrossrefMedlineGoogle Scholar10. JELLIFFE R, BUELL J, and KALABA R: Computer-assisted kanamycin dose programs (abstract). Clin Res 18:137, 1970 Google Scholar11. JELLIFFE R, KNIGHT R, and BUELL J: Computer assistance for gentamicin therapy (abstract). Ibid., p. 441 Google Scholar12. JELLIFFE R: Nomograms for kanamycin and gentamicin therapy. Abstracts of the Eleventh Interscience Conference on Antimicrobial Agents and Chemotherapy, Atlantic City, N. J., 19-22 October 1971, p. 63 Google Scholar13. CHAN R, BENNER E, and HOEPRICH P: A nomogram to guide safe, effective gentamicin therapy in patients with renal failure. Ibid. Google Scholar14. IVLER D, STAMBOULIAN D, and JELLIFFE R: Studies with computer programs for kanamycin and gentamicin therapy. Ibid., p. 64 Google Scholar15. CUTLER R and ORME B: Correlation of serum creatinine concentration and kanamycin half-life. JAMA 209:539, 1969 CrossrefMedlineGoogle Scholar16. GINGELL J and WATERWORTH P: Dose of gentamicin in patients with normal renal function and renal impairment. Br Med J 2:19, 1968 CrossrefMedlineGoogle Scholar17. MCHENRY M, GAVAN T, and GIFFORD R: Gentamicin dosages for renal insufficiency. Adjustments based on endogenous creatinine clearance and serum creatinine concentration. Ann Intern Med 74:192-197, 1971 LinkGoogle Scholar18. GYSELYNCK A, FLEET W, and CUTLER R: Gentamicin pharmacokinetics: distribution volume, renal and plasma clearance in normal subjects of renal insufficiency (abstract). Clin Res 19:183, 1971 Google Scholar19. JADRNÝ L: Odhad glomerulárni filtrace z kreatininémie. Cas Lek Cesk 104:947-949, 1965 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROGER W. JELLIFFE, M.D.; DANIEL IVLER, PH.D.Affiliations: Department of Medicine University of Southern California School of Medicine Los Angeles, Calif. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1972Volume 77, Issue 3Page: 480-481KeywordsDrugsGlycosidesPharmacokinetics ePublished: 1 December 2008 Issue Published: 1 September 1972 PDF downloadLoading ...