tbuckley/cabot-search huggingface dataset:
The C-C chemokine receptor CCR3 participates in stimulation of eosinophil arrest on inflammatory endothelium in shear flow.
Authors: J Kitayama, C R Mackay, P D Ponath, T A Springer
Journal: Journal of Clinical Investigation (1998)

Chemokines are widely hypothesized to stimulate firm adhesion of leukocytes on endothelium in shear flow. Thus far, this has been demonstrated experimentally for exogenously added chemoattractants, but not for those released by endothelium. We found that human umbilical cord endothelial cells (HUVEC) stimulated with TNF-alpha and IFN-gamma secreted eosinophil chemoattractants into the culture supernatant. This material induced transendothelial chemotaxis, stimulated eosinophil binding to purified intercellular adhesion molecule 1, and augmented binding to purified vascular cell adhesion molecule 1 in a 3-min static assay. Chemotaxis and stimulation of adhesion were abrogated completely by the pretreatment of eosinophils with an mAb to the C-C chemokine receptor 3 (CCR3). Eosinophils accumulated efficiently on HUVEC stimulated with TNF-alpha and IFN-gamma in shear flow at 1.5 dyn/cm2. CCR3 mAb slightly but significantly reduced eosinophil arrest and accumulation, by preventing development of firm adhesion by some of the tethered eosinophils, so that they detached within 30 s after the initial tethering. In the presence of mAb to the alpha4 integrin subunit, the effect of CCR3 mAb was more prominent, and approximately half of eosinophil arrest and accumulation was abolished. Inhibition by CCR3 mAb in the presence of beta2 integrin mAb was similar to that in control eosinophils. This is the first evidence that endothelial cell-derived chemokines can activate firm adhesion through alpha4 and beta2 integrins even in the presence of shear flow.
Use of glasses by adolescents with good vision.
Authors: P A Gardiner, C S Peckham
Journal: BMJ (1980)

complications.Three patients had haemoptysis and two slight epistaxis.Three patients vomited, including the one in whom the procedure was abandoned.There were 39 visible tumours.In 29 out of the 38 of these that were examined the histological opinion was definitive.Failure to make a positive diagnosis was associated with necrotic tumour tissue, previous radiotherapy, or a difficult biopsy.Where the appearance was of extrinsic compression a positive diagnosis was possible in only two out of 11 cases.In 11 cases examination showed non-malignant disease.
A CASE OF SYPHILITIC REINFECTION
Authors: Joseph Spangenthal
Journal: JAMA (1918)

Syphilitic reinfections are of such interest and of so infrequent occurrence that I consider this case worthy of being recorded. Fortunately for the authenticity of the diagnosis, it was my privilege to observe and treat the patient throughout both infections. M. H., a man, aged 28, consulted me in September, 1913, on account of a genital initial lesion the size of a dime. October 1, he presented a general secondary eruption, accompanied by angina, mucous patches, and involvement of the lymphatic glands. The physical signs were so typical and the diagnosis so unmistakable that it was not considered necessary to make a Wassermann test. In corroboration of the diagonsis, it will be of interest to give the history of his wife, whom he had infected. Several weeks after the patient's infection, the wife presented a secondary papular syphilid, angina, and mucous patches. The chancre involved the whole cervix uteri. About
Toward the Sliding Door
Authors: Jed Myers
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Forkheads, winged helices, and gastrointestinal epithelium
Authors: I R SANDERSON
Journal: Gut (1997)

Developmental abnormalities of the gastrointestinal tract are an important cause of morbidity in infants. Oesophageal atresia (incidence 1 in 2000 live births), Hirschsprung’s disease (1 in 5000), and duodenal atresia form much of the case work of a paediatric surgeon, yet virtually nothing is known about the molecular mechanisms that control gastrointestinal morphology. The article by Kaestner et al is the first to show how a regulatory gene in the embryo can alter gastrointestinal structure. They report morphological changes in the development of villi in the upper small intestine and the stomach epithelia.

Mesenchymal cells adjacent to the endoderm are central to the normal ontogeny of the gastrointestinal epithelium.1 2Kaestner et al examined a regulatory protein, Fkh6 (Forkhead homolog 6), which is expressed only in the mesenchyme adjacent to the developing endoderm that is destined to become epithelium. Fkh6 was therefore a candidate gene in the regulation of gastrointestinal development.3 Fkh6 is a member of the winged helix family of transcription factors, so called because of their appearance when bound to the DNA whose transcription they regulate.4 

Fkh6 was deleted from the genome of embryonic stem cells …
Physical and not mental health is impaired in very long-term survivors after HSCT compared with their respective donors: a paired analysis
Authors: Alicia Rovó, Thomas Daikeler, Martin Stern, Jörg Halter, Jan Dirk Studt, Andreas Buser, Dominik Heim, Johannes Rischewski, Michael Medinger, Alan Tyndall, Alois Gratwohl, André Tichelli
Journal: Blood (2008)
Endoscopic Ultrasound-Guided Pancreatic Duct Aspiration: Diagnostic Yield and Safety
Authors: R. Lai, M. W. Stanley, R. Bardales, B. Linzie, S. Mallery
Journal: Endoscopy (2002)

Endoscopic ultrasound (EUS)-guided fine-needle aspiration provides useful diagnostic material in solid and cystic pancreatic lesions. It is logical that EUS-guided pancreatic duct aspiration may be useful in cases of suspected intraductal or duct-obstructing tumors. We evaluated the safety and efficacy of EUS-guided pancreatic duct aspiration.Twelve patients with dilated pancreatic ducts underwent EUS-guided duct aspiration. Aspirates were submitted for cytology and mucin staining. Patients were followed for up to 13 months.There were no procedure-related complications. Cytology was diagnostic in nine of the 12 patients (six with intraductal papillary mucinous tumor, one with pancreatic clonorchiasis, and two with obstructing solid pancreatic adenocarcinomas). Cytology in the remaining three patients, all with solid obstructing masses, was nondiagnostic. Overall, the diagnostic yield was 75%; however, the yield was 100% in patients without extrinsic obstruction.This preliminary experience suggests that EUS-guided pancreatic duct aspiration is safe and can provide diagnostic material in a significant number of patients with unexplained pancreatic duct dilation.
925. pVGI.1 (VEGF2) Biodistribution in Swine Following Injection into Anterior Wall of the Left Ventricle Using the Stiletto™ Endocardial Direct Injection Catheter System
Authors: Qing Wang, Yawen L. Chiang
Journal: Molecular Therapy (2005)

Intramyocardial delivery of vascular endothelial growth factor-C (VEGF-2) has shown physiologic and anatomic evidence of angiogenesis both in animal models and clinical trials for myocardial ischemia. A large phase IIb clinical trial (the Genasis trial) is ongoing to evaluate the safety and efficacy of pVGI.1 (VEGF2) for treatment of severe cardiovascular disease. We report here a nonclinical study to examine biodistribution of the pVGI.1 (VEGF2) plasmid DNA following direct injection via the Stiletto|[trade]| Endocardial Direct Injection Catheter System into myocardium of the left ventricle of normal pigs.
Training for Primary Care
Authors: LAWRENCE KAHN
Journal: Annals of Internal Medicine (1978)

Letters and Corrections1 January 1978Training for Primary CareLAWRENCE KAHN, M.D., GERALD T. PERKOFF, M.D.LAWRENCE KAHN, M.D.Search for more papers by this author, GERALD T. PERKOFF, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-88-1-127 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The paper "Primary Care Residency Training: The First Five Years" (1) by J. I. Boufford is an excellent description of a pioneer program for training residents in social medicine. Our experiences at Washington University School of Medicine confirm those of the group at Montefiore Hospital in many but not in all respects.The primary care teaching program here is a residency option in pediatrics or internal medicine at the Medical Care Group of Washington University (MCG), a campus-based teaching and research prepaid group practice.Unlike the Residency Program in Social Medicine (RPSM) at Montefiore Hospital, a pair-system...References1. BOUFFORD J: Primary care residency training: the first five years. Ann Intern Med 87:359-368, 1977 LinkGoogle Scholar2. KAHNWIRTHPERKOFF LPG: The cost of a primary care teaching program in a prepaid group practice. Med Care, in press Google Scholar3. STERNJENNINGSDELBANCODORSEYSTOECKLELAWRENCE RMTJJR: Graduate education in primary care: an economic analysis. N Engl J Med 297:638-643, 1977 CrossrefMedlineGoogle Scholar1. GOROLLSTOECKLEGOLDFINGERO'MALLEYMAYWOOFOLLAYTTARSWEET AJSTLBSR: Residency training in primary care internal medicine. Report of an operational program. Ann Intern Med 83:872-877, 1975 LinkGoogle Scholar2. PERLMANGRAHAMCHRISTY LTW: Primary care internal medicine residencies. Arch Intern Med 136:111-113, 1976 CrossrefMedlineGoogle Scholar3. : Attributes of the general internist and recommendations for training. Ann Intern Med 86:472-473, 1977 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Division of Health Care Research Washington University School of Medicine St. Louis, MO 63110 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByRestructuring an internal medicine residency program to meet regional and national needs for general internists 1 January 1978Volume 88, Issue 1Page: 127-128KeywordsHospital medicinePediatricsPrimary careResidency Issue Published: 1 January 1978 PDF DownloadLoading ...
F-18 FDG Uptake in Focal Fatty Infiltration of Liver Mimicking Hepatic Malignancy on PET/CT Images
Authors: Young Hwan Kim, Ji Young Kim, Sung June Jang, Hyun Woo Chung, Ki-Seok Jang, Seung Sam Paik, Soon-Young Song, Yun Young Choi
Journal: Clinical Nuclear Medicine (2011)

Hepatic masses detected by ultrasonography and computed tomography in a young woman showed increased radioactivity on F-18 fluorodeoxyglucose positron tomography. Those multiple hepatic lesions were investigated under suspicion of malignancy. Liver enzymes, viral markers, and tumor markers were in normal range. Ultrasonography-guided needle biopsy revealed to be focal fatty infiltration in the liver.
Colocalization of basic fibroblast growth factor and CD44 isoforms containing the variably spliced exon v3 (CD44v3) in normal skin and in epidermal skin cancers
Authors: H.U. Grimme, C.C. Termeer, K.L. Bennett, J.M. Weiss, E. Schopf, A. Aruffo, J.C. Simon
Journal: British Journal of Dermatology (1999)

Journal Article Colocalization of basic fibroblast growth factor and CD44 isoforms containing the variably spliced exon v3 (CD44v3) in normal skin and in epidermal skin cancers Get access H.U. Grimme, H.U. Grimme Department of Dermatology, University of Freiburg, Hauptstr. 7, D‐79104 Freiburg, Germany Search for other works by this author on: Oxford Academic Google Scholar C.C. Termeer, C.C. Termeer Department of Dermatology, University of Freiburg, Hauptstr. 7, D‐79104 Freiburg, Germany Search for other works by this author on: Oxford Academic Google Scholar K.L. Bennett, K.L. Bennett Bristol‐Myers‐Squibb Pharmaceutical Research Institute, Princeton, WA, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar J.M. Weiss, J.M. Weiss Department of Dermatology, University of Freiburg, Hauptstr. 7, D‐79104 Freiburg, Germany Search for other works by this author on: Oxford Academic Google Scholar E. Schöpf, E. Schöpf Department of Dermatology, University of Freiburg, Hauptstr. 7, D‐79104 Freiburg, Germany Search for other works by this author on: Oxford Academic Google Scholar A. Aruffo, A. Aruffo Bristol‐Myers‐Squibb Pharmaceutical Research Institute, Princeton, WA, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar J.C. Simon J.C. Simon Department of Dermatology, University of Freiburg, Hauptstr. 7, D‐79104 Freiburg, Germany Jan C.Simon. E‐mail: simonJ@hau1.ukl.uni‐freiburg.de Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 141, Issue 5, 1 November 1999, Pages 824–832, https://doi.org/10.1046/j.1365-2133.1999.03154.x Published: 01 November 1999
Disseminated Candidiasis in a Patient With Acute Leukemia
Authors: Martin E. Katz
Journal: JAMA (1977)

THE ADMINISTRATION of chemotherapy to patients with adult acute nonlymphocytic leukemia presently yields a 50% to 60% complete remission rate.<sup>1</sup>Death from infection remains a major factor in preventing a higher proportion of patients from obtaining a complete remission.<sup>2</sup>Candidiasis is the most frequent fungal infection in patients with leukemia<sup>3</sup>and is often difficult to treat despite the use of amphotericin B with or without flucytosine. Amphotericin B may cause true anaphylaxis, fever, chills, hypotension, skin rash, nausea, vomiting, anorexia, anemia, azotemia, and renal tubular acidosis.<sup>4,5</sup> Miconazole nitrate is a synthetic 1-phenethylimidazole derivative, 1-2,4-dichloro-β(2,4-dichlorobenzyloxy) phenethylimidazole nitrate with broad-spectrum antifungal and antibacterial activity.<sup>6</sup>Miconazole has been used in the treatment of coccidioidomycosis with moderate success.<sup>7</sup>Phlebitis at the site of infusion has been the only recognized side effect and can often be avoided by the use of a central venous catheter. We report here the
Revisiting the harem conspiracy and death of Ramesses III: anthropological, forensic, radiological, and genetic study
Authors: Z. Hawass, S. Ismail, A. Selim, S. N. Saleem, D. Fathalla, S. Wasef, A. Z. Gad, R. Saad, S. Fares, H. Amer, P. Gostner, Y. Z. Gad, C. M. Pusch, A. R. Zink
Journal: BMJ (2012)

<b>Objective</b> To investigate the true character of the harem conspiracy described in the Judicial Papyrus of Turin and determine whether Ramesses III was indeed killed. <b>Design</b> Anthropological, forensic, radiological, and genetic study of the mummies of Ramesses III and unknown man E, found together and taken from the 20th dynasty of ancient Egypt (circa 1190-1070 BC). <b>Results</b> Computed tomography scans revealed a deep cut in Ramesses III's throat, probably made by a sharp knife. During the mummification process, a Horus eye amulet was inserted in the wound for healing purposes, and the neck was covered by a collar of thick linen layers. Forensic examination of unknown man E showed compressed skin folds around his neck and a thoracic inflation. Unknown man E also had an unusual mummification procedure. According to genetic analyses, both mummies had identical haplotypes of the Y chromosome and a common male lineage. <b>Conclusions</b> This study suggests that Ramesses III was murdered during the harem conspiracy by the cutting of his throat. Unknown man E is a possible candidate as Ramesses III's son Pentawere.
Endoclips as Nidus for Choledocholithiasis Presenting 5 Years After Laproscopic Cholecystectomy
Authors: S. Khanna, J. C. Vij
Journal: Endoscopy (2005)

Figure 1 a, b A middle-aged lady presented to our unit with progressively worsening jaundice of 5 days' duration. There had been no preceding prodrome. Based on the clinical features and liver function tests she was diagnosed as having surgical obstructive jaundice. Ultrasound showed dilated intrahepatic biliary radicals and a common bile duct (CBD) dilated as far as the lower end. The patient had undergone laparoscopic cholecystectomy for gallstone disease 5 years previously. On endoscopic retrograde cholangiography it was found that she had a stone, for which surgical clips had served as a nidus, at the lower end of the CBD. The stone was removed endoscopically and the patient improved. The migration of surgical clips as a complication of laparoscopic cholecystectomy is a rare but increasingly diagnosed complication.
New rules of consent: the patient decides
Authors: F. Godlee
Journal: BMJ (2015)

How much information should patients be given about the risks of treatment? And who decides what a patient needs to know? Until now, in the United Kingdom, doctors have been allowed to decide this, and the 30 year old Bolam test specified that their conduct would be considered acceptable if it would be supported by a responsible body of medical opinion.

But this has all just changed. Last week the UK’s Supreme Court judged that it was for patients to decide whether the risks of treatment and alternative options have been adequately communicated. Nadine Montgomery, who has diabetes, was not told of the risks …
A METHOD OF SUPRAPUBIC HYSTERECTOMY FOR GOOD OPERATORS AND BAD FIBROIDS.
Authors: JOSEPH EASTMAN
Journal: JAMA (1895)

The lines of sound surgical principles converge toward perfection of technique in operating and the ideal operation. The proximity to the ideality of an operation is in direct ratio to the simplicity of its technique and the results obtained. Ideal results in suprapubic hysterectomy are best secured by ideal operators with ideal surroundings, upon ideal patients with symmetrically formed pear-shaped tumors. I serve notice, in this presence, on those engaged in discussing the technique of hysterectomy that they can not have the last word until their means and methods shall deal with fibroid tumors, regardless of their morphology or pathologic condition, nor until the average operator shall advise the removal of fibroids as unhesitatingly as he does an ovarian cyst. Despite the efforts of some to name a distinct method of operating because a flap is made here, or a ligature placed there, the problems of suprapubic hysterectomy are rapidly
THE VALUE OF LUMBAR PUNCTURE IN GENERAL PRACTICE
Authors: H. Rhodes
Journal: BMJ (1903)

MEDTCAL JOUNAL 7 I found her in a remarkably good state of health generally; she was mnuch stouter and very cheerful.Wlhen she left the infirmary in February, I894, she could only use affirmatives aud negatives.It was several montuhs after this before she could utter the words " father " and "mother."When I saw her in Septemiiber, I9OI, she was then able to 'make use of a very large number of words.She could name any
Transdifferentiation of rat hepatocytes into biliary cells after bile duct ligation and toxic biliary injury
Authors: George K. Michalopoulos, Lindsay Barua, William C. Bowen
Journal: Hepatology (2005)

Rats with chimeric livers were generated by using the protocol of injecting hepatocytes from dipeptidyl peptidase IV (DPPIV)-positive donors into retrorsine-treated DPPIV-negative recipients subjected to partial hepatectomy. Rats with established chimeric livers were subjected to bile duct ligation, with or without pretreatment with the biliary toxin methylene diamiline (DAPM). Ductules bearing the donor hepatocyte marker DPPIV were seen at 30 days after bile duct ligation. The frequency of the ductules derived from the donor hepatocytes was dramatically enhanced (36-fold) by the pretreatment with DAPM. In conclusion, our results show that hepatocytes can function as facultative stem cells and rescue the biliary epithelium during repair from injury when its proliferative capacity is being compromised. (HEPATOLOGY 2005;41:535–544.)
Fifth anniversary changes for NHS reforms
Authors: J. Warden
Journal: BMJ (1996)

One of the architects of the NHS reforms said that the changes would need five years to take root. The five years are now almost up, and there is little dispute that the reforms are indeed rooted too deeply for there to be any inclination to dig them up and start again. A future Labour government plainly would not do so, though that does not imply any narrowing of the political divide that the reforms have provoked from the start. This was confirmed as recently as last week when the House of Lords debated the state of the NHS. Junior health minister Lady Cumberlege said that it was the best health service in the world. But according to Labour's new medical peer, Lord …
Comparison of two new methods for the measurement of lung volumes with two standard methods
Authors: I. J Cliff, A. H Evans, C. F A Pantin, D. R Baldwin
Journal: Thorax (1999)

<h3>BACKGROUND</h3> The two most commonly used methods for the measurement of lung volumes are helium dilution and body plethysmography. Two methods have been developed which are both easier and less time consuming to perform. Mathematical modelling uses complex calculations from the flow-volume loop to derive total lung capacity (TLC), and the nitrogen balance technique uses nitrogen from the atmosphere to calculate lung volume in a similar way to helium dilution. This study was designed to compare the two new methods with the two standard methods. <h3>METHODS</h3> Sixty one subjects were studied, 23 with normal lung function, 17 with restrictive airway disease, and 21 with obstructive ventilatory defects. Each subject underwent repeated measurements of TLC by each of the four methods in random order. Reproducible values were obtained for each method according to BTS/ARTP guidelines. Bland-Altman plots were constructed for comparisons between the methods and paired<i>t</i> tests were used to assess differences in means. <h3>RESULTS</h3> Bland-Altman plots showed that the differences between body plethysmography and helium dilution fell into clinically acceptable ranges (agreement limits ±0.9 l). The agreement between mathematical modelling or the nitrogen balance technique and helium dilution or body plethysmography was poor (±1.8–3.4 l), especially for subjects with airflow obstruction. <h3>CONCLUSIONS</h3> Neither of the new methods agrees sufficiently with standard methods to be useful in a clinical setting.
GM-CSF Controls Nonlymphoid Tissue Dendritic Cell Homeostasis but Is Dispensable for the Differentiation of Inflammatory Dendritic Cells
Authors: Melanie Greter, Julie Helft, Andrew Chow, Daigo Hashimoto, Arthur Mortha, Judith Agudo-Cantero, Milena Bogunovic, Emmanuel L. Gautier, Jennifer Miller, Marylene Leboeuf, Geming Lu, Costica Aloman, Brian D. Brown, Jeffrey W. Pollard, Huabao Xiong, Gwendalyn J. Randolph, Jerry E. Chipuk, Paul S. Frenette, Miriam Merad
Journal: Immunity (2012)