tbuckley/cabot-search huggingface dataset:
Platelet Aggregation and Thrombotic Vascular Disease
Authors: ROBERT W. COLMAN
Journal: Annals of Internal Medicine (1975)

EditorialsJune 1, 1975Platelet Aggregation and Thrombotic Vascular DiseaseROBERT W. COLMAN, M.D., F.A.C.P.ROBERT W. COLMAN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-82-6-839 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThrombosis, frequently the final event in coronary or cerebral arterial occlusion, is a result of the interplay of abnormalities of the vessel wall, hemodynamic forces, plasma coagulant proteins, and platelets. Platelets are thought to initiate a series of intricate reactions by adhering to the injured arterial lining, aggregating irreversibly to form a platelet plug, and releasing vasoactive metabolites and hydrolytic enzymes that might in turn alter both the function and structure of the vessel. Heightened platelet function thus might not only participate in the formation of thrombi but also may play a role in the development or progression of some...References1. SANOBOXERBOXER TML: Platelet sensitivity to aggregation in normal and diseased groups. A method for assessment of platelet aggregability. Thromb Diath Haemorrh 25:524-531, 1971 MedlineGoogle Scholar2. GOLDENFARBCATHEYZUCKER PMS: Changes in the hemostatis mechanism after myocardial infarction. Circulation 43:538-546, 1971 CrossrefMedlineGoogle Scholar3. FRISHMANWEKSLERCHRISTODOULOU WBJ: Reversal of abnormal platelet aggregability and change in exercise tolerance in patients with angina pectoris following oral propranolol. Circulation 50:887-896, 1974 CrossrefMedlineGoogle Scholar4. CARVALHOCOLMANLEES ARR: Platelet function in hyperlipoproteinemia. N Engl J Med 290:434-438, 1974 CrossrefMedlineGoogle Scholar5. CARVALHOCOLMANLEES ARR: Clofibrate reversal of platelet hypersensitivity in hyperbetalipoproteinemia. Circulation 50:570-574, 1974 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Coagulation Unit Hematology-Oncology Section Department of Medicine Hospital of the University of Pennsylvania Philadelphia, Pennsylvania PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics June 1, 1975Volume 82, Issue 6Page: 839-839KeywordsHypersensitivityPlatelets Issue Published: June 1, 1975 PDF downloadLoading ...
Nickel allergy: relationship between patch test and repeated open application test thresholds
Authors: L.A. Fischer, J.D. Johansen, T. Menné
Journal: British Journal of Dermatology (2007)

Background The frequency of nickel allergy varies between different population groups. Exposure regulation has proven effective in decreasing the frequency. Experimental studies with other allergens have shown a significant relation between patch test reactivity and repeated open application test (ROAT) reactivity. Objectives This study was aimed at determining the elicitation threshold in nickel‐allergic individuals in a patch test and a ROAT, and comparing the threshold from these two test methods. Methods Twenty nickel‐allergic persons were tested with a dilution series of 19 concentrations in a patch test and a dilution series of three concentrations in a ROAT, with duration of up to 21 days. Eighteen persons with no nickel allergy were included as control group for the ROAT. Results The predicted dose which will elicit a reaction in 10% of allergic individuals was calculated to be 0·78 μg nickel cm−2 in the patch test. The threshold for the ROAT (in μg nickel cm−2 per application) was significantly lower than the threshold for the patch test, while the dose–response for the accumulated ROAT dose at 1 week, 2 weeks and 3 weeks was very similar to the patch test dose–response; indeed, there was no statistically significant difference. Conclusions For elicitation of nickel allergy the elicitation threshold for the patch test is higher than the elicitation threshold (per application) for the ROAT, but is approximately the same as the accumulated elicitation threshold for the ROAT. This may be important for risk assessment based on dose–response results from allergic patients.
THE HISTOLOGICAL DIAGNOSIS OF PEMPHIGUS.*
Authors: A. J. ROOK, I. W. WHIMSTER
Journal: British Journal of Dermatology (1950)

Journal Article THE HISTOLOGICAL DIAGNOSIS OF PEMPHIGUS. Get access A. J. ROOK, M. A., M.B.Cantab., M. R. C.P.Lond., A. J. ROOK, M. A., M.B.Cantab., M. R. C.P.Lond. Department for Diseases of the Skin, St. Thomas's Hospital Search for other works by this author on: Oxford Academic Google Scholar I. W. WHIMSTER, M.B., B.Chir. Cantab. I. W. WHIMSTER, M.B., B.Chir. Cantab. Department for Diseases of the Skin, St. Thomas's Hospital Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 62, Issue 11, 1 November 1950, Pages 443–446, https://doi.org/10.1111/j.1365-2133.1950.tb14365.x Published: 01 November 1950
Medical School Response to Physician Excess
Authors: Ferris M. Hall
Journal: JAMA (1985)

<h3>To the Editor.—</h3> There is a general agreement about the qualitative accuracy of the 1980 to 1982 Graduate Medical Education National Advisory Committee (GMENAC) reports of a substantial, almost across-the-board surplus of US physicians. This is not surprising in the light of the almost doubling of the number of medical school graduates from 1970 to 1980, and a present ratio of 2.2 physicians per 1,000 citizens. What is surprising is the lack of public discussion about this problem. There is a divergence of opinion between the town and the gown medical communities regarding the implementation of the GMENAC recommendations. Medical school class size has diminished only minimally since 1982, and little further decrease is anticipated. Academic discussions of this issue have centered less on domestic medical school enrollment than on the related and also important questions of foreign medical graduates, distribution of physicians within medical specialties, and geographic maldistribution of
Goals of Education in Psychosomatic Medicine
Authors: Hoyle Leigh, Morton F. Reiser
Journal: Psychotherapy and Psychosomatics (1979)

The modern concept of psychosomatic medicine is based on a multifactorial, interactional systems model for all diseases in which the behavioral and social dimensions play important roles in the pathogenesis, manifestation, course, and outcome. This psychosomatic approach forms the philosophical underpinning of a modern educational program. A general goal of education for all physicians is understanding the behavioral and psychosocial factors in all illness. Specific goals for the primary physician and the psychiatrist are the instillation of a holistic attitude in patient care through systematic training, and the attainment of skills and knowledge to integrate behavioral and biomedical sciences, respectively. This includes specific diagnostic, treatment, and educational skills. Yale's multilevel educational program in psychosomatic medicine is described.
Ten Years at the Lymanhurst School for Tuberculous Children
Authors: J. ARTHUR MYERS
Journal: Annals of Internal Medicine (1932)

Article1 November 1932Ten Years at the Lymanhurst School for Tuberculous ChildrenJ. ARTHUR MYERS, M.S., PH.D., M.D., F.A.C.P.J. ARTHUR MYERS, M.S., PH.D., M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-6-5-672 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptNumerous cross section studies of tuberculosis have been made. In this paper is reported the first ten years of a longitudinal study undertaken at the Lymanhurst School for Tuberculous Children. The chief value of the work at Lymanhurst has been in the opportunity to follow the cases over periods of years, and in so doing to write the history of their tuberculous lesions. The medical staff engaged in this work is confident that the true story of tuberculosis in the human body has never been told and that it will not be told until this group or some other group... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Minneapolis, Minn.From the Departments of Preventive Medicine and Internal Medicine, University of Minnesota, and the Lymanhurst School for Tuberculous Children, Minneapolis, Minnesota.Prepared with the aid of a grant from the Medical Research Fund of the University of Minnesota.Presented before the Sixteenth Annual Meeting of the American College of Physicians, San Francisco, April 5, 1932. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByKind und Kinderarzt im Geordneten Kampfe Gegen die Tuberkulose als VolkskrankheitIl problema della tubercolosi nell'infanzia in rapporto alla profilassi e terapia. Relatori.: Kind und Kinderarzt im geordneten Kampfe gegen die TuberkuloseTuberculosis in childrenTuberculosis in children 1 November 1932Volume 6, Issue 5Page: 672-688KeywordsChildrenLesionsLongitudinal studiesMedical staffPreventive medicineResearch funding Issue Published: 1 November 1932 PDF DownloadLoading ...
Heart Rate Alternans
Authors: David H. Spodick
Journal: Annals of Internal Medicine (1995)

Letters1 September 1995Heart Rate AlternansDavid H. Spodick, MD, DScDavid H. Spodick, MD, DScSaint Vincent Hospital; Boston, MA 01604Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-123-5-199509010-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Although their report of the power-density spectrum of heart rate variability is new and valuable, Binkley and colleagues' [1] belief that they have discovered heart rate alternans in pulsus alternans is mistaken. Their patient's cycle length alternation is reported as uncharacteristic; however, the opposite is true. Heart rate cycle alternation has been known for many decades and was always seen in our investigations [2, 3] of pulsus alternans. Indeed, in 1956, Friedman [4] carefully reviewed this characteristic phenomenon, with a good discussion of its probable causes. Unfortunately, this information must have escaped the peer reviewers, whose work ...References1. Binkley PF, Eaton GM, Nunziata E, Khot U, Cody RJ. Heart rate alternans. Ann Intern Med. 1995; 122:115-7. Google Scholar2. Spodick DH, St. Pierre JR. Pulsus alternans. Physiologic study by nonivasive techniques. Ann Heart J. 1976; 80:766-77.Appendix Google Scholar3. Spodick DH, Khan AH, Pigott VM. Systolic and diastolic time intervals in pulsus alternans. Am Heart J. 1974; 87:5-10. Google Scholar4. Friedman B. Alternations of cycle length impulsus alternans. Am Heart J. 1956; 51:701-12. Google Scholar5. Spodick DH. Peer review system ACP Observer. 1985; 5:9-10. Google Scholar Author, Article, and Disclosure InformationAffiliations: Saint Vincent Hospital; Boston, MA 01604 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1995Volume 123, Issue 5Page: 393-394KeywordsHeart rate Issue Published: 1 September 1995 CopyrightCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
THE PHARMACOLOGY OF THE NITRO-SUGARS.
Authors: C. R. AMARSHALL
Journal: JAMA (1901)

The nitro-sugars are in reality nitrate-esters, and are closely allied to nitroglycerin and other members of this class. They were first prepared, along with other organic nitrates, by Schonbein<sup>1</sup>(1845), then by Sobrero<sup>2</sup>(1847) and Flores Demonte and Minard<sup>3</sup>(1847). The whole class of bodies obtained by these observers was made by simple nitration, and this led to the name "nitro" being given to them. Subsequently another class of substances possessing entirely different physical and chemical properties was obtained, and, on reduction, yielded amido compounds. To these the name of nitro-compounds has been restricted. It was shown later that nitroglycerin did not yield an amido compound and, therefore, it could not be a true nitro body. It is in fact a nitrate. The differences may be expressed, taking the derivatives of etham as examples, thus: C<sub>2</sub>H<sub>5</sub>—NO<sub>2</sub>C<sub>2</sub>H<sub>5</sub>—ONO C
Retroanastomotic Herniation Mimicking Biliary Leakage in a Cholescintigraphic Pattern
Authors: REN-SHYAN LIU, TZU-CHEN YEN, SHOU-JEN KUO, SHIN-HWA YEH
Journal: Clinical Nuclear Medicine (1987)

Retroanastomotic hernia (internal hernia) is a rare but serious complication subsequent to gastrojejunal anastomoses. The authors present a case of retroanastomotic hernia with the cholescintigraphic findings mimicking the pattern of biliary leakage.
Spontaneously Resolving Lower Polar ATN in a Transplant Kidney With Dual Vascular Supply Demonstrated on 99mTc EC Renography
Authors: Madhavi Tripathi, Chandan Jyoti Das, Krishna Kant Agarwal, Bangkim Chandra Khangembam, Varun Singh Dhull
Journal: Clinical Nuclear Medicine (2013)

We report the presence of a differential acute tubular necrosis pattern on renography in a renal transplant recipient who had received a donor kidney with dual renal arterial supply. The proximal accessory renal artery was supplying the lower pole which had been demonstrated on CT angiography. This possibility should be kept in mind while reporting renography with tubular agents like 99mTc EC in transplant patients. Follow-up renography effectively demonstrated spontaneous resolution of the differential retention pattern and acute tubular necrosis. This case reiterates the usefulness of retention of tubular tracers like 99mTc EC for detection of tubular necrosis.
Steroid‐responsive pulmonary disorders associated with myelodysplastic syndromes with der(1q;7p) chromosomal abnormality
Authors: Takafumi Matsushima, Hirokazu Murakami, Koho Kim, Hideki Uchiumi, Naoya Murata, Jun'Ichi Tamura, Morio Sawamura, Masamitsu Karasawa, Takuji Naruse, Jun Tsuchiya
Journal: American Journal of Hematology (1995)

Abstract We report three patients with pulmonary disorders associated with myelodysplastic syndromes (MDS). All three patients had symptoms of pyrexia and respiratory discomfort. One patient had pulmonary eosinophilia with bilateral pleural effusion, one had interstitial pneumonia, and one had bilateral pleural effusion caused by systemic vasculitis. Elevated C‐reactive protein (CRP) levels, polyclonal hypergammaglobulinemia, and morphological abnormalities in peripheral blood were observed in all three patients. The bone marrow of these patients revealed trilineage dysplasia and eosinophilia. Cytogenetic analysis showed [46,XY,‐7,+der(1q;7p)]. Antibiotic treatment was not effective. However, improvement was dramatic after corticosteroid treatment; CRP levels were reduced and the hypergammaglobulinemia was improved. These cases suggest that MDS with [‐7,+der(1q;7p)] may be correlated with bone marrow eosinophilia and that an immunologic abnormality may be involved in the pulmonary disorders.
Relation of Platelet and Leukocyte Inflammatory Transcripts to Body Mass Index in the Framingham Heart Study
Authors: Jane E. Freedman, Martin G. Larson, Kahraman Tanriverdi, Christopher J. O'Donnell, Kristine Morin, Amanda S. Hakanson, Ramachandran S. Vasan, Andrew D. Johnson, Mark D. Iafrati, Emelia J. Benjamin
Journal: Circulation (2010)

Background— Although many genetic epidemiology and biomarker studies have been conducted to examine associations of genetic variants and circulating proteins with cardiovascular disease and risk factors, there has been little study of gene expression or transcriptomics. Quantitative differences in the abundance of transcripts has been demonstrated in malignancies, but gene expression from a large community-based cohort examining risk of cardiovascular disease has never been reported. Methods and Results— On the basis of preliminary microarray data and previously suggested genes from the literature, we measured expression of 48 genes by high-throughput quantitative reverse-transcriptase polymerase chain reaction in 1846 participants of the Framingham Offspring cohort from RNA derived from isolated platelets and leukocytes. A multivariable stepwise regression model was used to assess clinical correlates of quantitative RNA expression. For specific inflammatory platelet-derived transcripts, including ICAM1 , IFNG , IL1R1 , IL6 , MPO , COX2 , TNF , TLR2 , and TLR4 , there were significant associations with higher body mass index (BMI). Compared with platelets, fewer leukocyte-derived transcripts were associated with BMI or other cardiovascular risk factors. Select transcripts were found to be highly heritable, including GPIBA and COX1 . Almost uniformly, heritable transcripts were not those associated with BMI. Conclusions— Inflammatory transcripts derived from platelets, particularly those part of the nuclear factor κ B pathway, are associated with BMI, whereas others are heritable. This is the first study, using a large community-based cohort, to demonstrate clinical correlates of gene expression and is consistent with the hypothesis that specific peripheral-blood transcripts play a role in the pathogenesis of coronary heart disease and its risk factors.
Detection of Bleeding from Angiodysplasia of the Jejunum by Blood Pool Scintigraphy
Authors: SABAH S. TU??MEH, J ANTHONY PARKER, HENRY D. ROYAL, ROGER F. UREN, GERALD M. KOLODNY
Journal: Clinical Nuclear Medicine (1983)

Bleeding from angiodysplasia of the gastrointestinal tract has become widely recognized. In most patients there is a single focal lesion in the colon. Small bowel involvement is rare and usually associated with colonic lesions. There have been no reports of bleeding angiodysplasia affecting the small bowel only. We were able to detect bleeding from an isolated angiodysplasia of the jejunum and correctly localize it. Our diagnosis was greatly aided by the use of dynamic data collection and by the cinematic display of the data.
ACAT inhibitors as antiatherosclerotic agents: Compounds and mechanisms
Authors: Koyo Matsuda
Journal: Medicinal Research Reviews (1994)

Atherosclerosis is a major death cause in western industrialized countries. A diagnosing system, medical prevention, and treatment of atherosclerosis is not sufficient so far. A direct acting antiatherosclerotic agent is eagerly waited. ACAT inhibitor approach could provide such an agent. In the formation of atherosclerosis, cholesteryl esters, which are the lipids which accumulate in atheromatous plaques by an aid of macrophages and smooth muscle cells, forming foam cells, may play an important role. ACAT enzyme is responsible for the acylation of cholesterol to cholesteryl esters, a transformation which can be essential in not only cholesteryl esters accumulation at arterial walls but also the absorption of cholesterol in the intestine and the excretion of cholesterol in the liver. From these points, ACAT inhibitors might work against atherosclerosis in three different ways: first, cholesteryl ester accumulation inhibition at arterial walls could be a direct antiatherosclerotic effect; second, cholesterol absorption inhibition at the intestine; and third, cholesterol excretion acceleration at the liver, while the later two effects would result in a reduction of blood cholesterol level--a major risk factor of atherosclerosis. Taking account of this discussion, the ACAT inhibitors would be potent antiatherosclerotic agents. Medicinal research has been contributing full strength to produce an ultimate compound. These efforts should provide a drug which will be useful to patients.
INFLAMMATION IMAGING WITH A Tc-99m-LABELLED TUFTSIN ANTAGONIST
Authors: L. L.P. Tran, F. Lau, S. Eriksson, J. Ballinger, A. Pollak, A. E. Goodbody
Journal: Clinical Nuclear Medicine (1995)

Tran, L. L.P.; Lau, F.; Eriksson, S.; Ballinger, J.; Pollak, A.; Goodbody, A. E. Author Information
Abstract 2785: Discovery of a novel HDM2 inhibitor with potent in vivo anti-tumor activity
Authors: Yaolin Wang, Philip Lipari, Asra Mirza, Yinghui Lin, Rumin Zhang, Stephane Bogen, Stephane Bogen, Yao Ma, Daniel J. Hicklin, Cynthia Seidel-Dugan, Suxing Liu, Xiaoying Wang, Ronald Doll, Gerald Shipps, Walter Robert Bishop
Journal: Cancer Research (2012)

Abstract HDM2 is a major negative regulator of the p53 tumor suppressor pathway. Aberrant HDM2 overexpression and gene amplification contributed to accelerated cancer development and growth. Several small molecule inhibitors of HDM2-p53 protein-protein interaction have been reported in recent years with anti-tumor activities in tumor xenograft models. Here we describe a novel and potent small molecule inhibitor of HDM-p53 inhibitor that binds selectively to HDM2 with high affinity compared to HDM4. Treatment of cancer cells with this HDM2 inhibitor results in activation of p53 pathway as demonstrated by study of pharmacodynamic biomarkers both in cell culture and in tumor xenograft in vivo. More importantly, cancer cells response to this HDM2 inhibitor is mechanism based and dependent on the presence of functional p53 status as shown in a profiling of a broad-panel of cancer cell lines. This inhibitor is very potent against cancer cell growth with IC50 below 200 nM for most cell lines tested in vitro. It is orally bioavailable and has single agent activity that results tumor regression in SJSA-1 osteosarcoma model or growth inhibition in A549 NSCLC and A2780 ovarian cancer xenograft models. In addition, combination of this HDM2 inhibitor with various chemotherapy agents results in added or synergistic anti-tumor response both in vitro and in vivo in several human cancer xenograft models with limited bone marrow toxicity at the efficacious dose. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2785. doi:1538-7445.AM2012-2785