tbuckley/cabot-search huggingface dataset:
Localized heat urticaria in a patient is associated with a wealing response to heated autologous serum
Authors: A. Fukunaga, S. Shimoura, M. Fukunaga, M. Ueda, H. Nagai, T. Bito, K. Tsuru, M. Ichihashi, T. Horikawa
Journal: British Journal of Dermatology (2002)

Journal Article Localized heat urticaria in a patient is associated with a wealing response to heated autologous serum Get access A. Fukunaga, A. Fukunaga Division of Dermatology, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7‐5‐1 Kusunoki‐cho, Chuo‐ku, Kobe, 650‐0017, Japan Search for other works by this author on: Oxford Academic Google Scholar S. Shimoura, S. Shimoura Division of Dermatology, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7‐5‐1 Kusunoki‐cho, Chuo‐ku, Kobe, 650‐0017, Japan Search for other works by this author on: Oxford Academic Google Scholar M. Fukunaga, M. Fukunaga Division of Dermatology, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7‐5‐1 Kusunoki‐cho, Chuo‐ku, Kobe, 650‐0017, Japan Search for other works by this author on: Oxford Academic Google Scholar M. Ueda, M. Ueda Division of Dermatology, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7‐5‐1 Kusunoki‐cho, Chuo‐ku, Kobe, 650‐0017, Japan Search for other works by this author on: Oxford Academic Google Scholar H. Nagai, H. Nagai Division of Dermatology, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7‐5‐1 Kusunoki‐cho, Chuo‐ku, Kobe, 650‐0017, Japan Search for other works by this author on: Oxford Academic Google Scholar T. Bito, T. Bito Division of Dermatology, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7‐5‐1 Kusunoki‐cho, Chuo‐ku, Kobe, 650‐0017, Japan Search for other works by this author on: Oxford Academic Google Scholar K. Tsuru, K. Tsuru Division of Dermatology, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7‐5‐1 Kusunoki‐cho, Chuo‐ku, Kobe, 650‐0017, Japan Search for other works by this author on: Oxford Academic Google Scholar M. Ichihashi, M. Ichihashi Division of Dermatology, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7‐5‐1 Kusunoki‐cho, Chuo‐ku, Kobe, 650‐0017, Japan Search for other works by this author on: Oxford Academic Google Scholar T. Horikawa T. Horikawa Division of Dermatology, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7‐5‐1 Kusunoki‐cho, Chuo‐ku, Kobe, 650‐0017, Japan Tatsuya Horikawa, M.D. E‐mail: thorikaw@med.kobe‐u.ac.jp Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 147, Issue 5, 1 November 2002, Pages 994–997, https://doi.org/10.1046/j.1365-2133.2002.04952.x Published: 01 November 2002 Article history Accepted: 04 March 2002 Published: 01 November 2002
Hypertrophic scar formation following carbon dioxide laser ablation of plantar warts in cyclosporin-treated patients.
Authors: S.M. Ozluer, B.Y. Chuen, R.J. Barlow, A.C. Markey
Journal: British Journal of Dermatology (2001)

We present four renal transplant patients who developed hypertrophic scars following carbon dioxide laser ablation of recalcitrant plantar warts. All of the patients were on long-term treatment with cyclosporin, which we believe to be responsible. We discuss several possible mechanisms by which cyclosporin may influence wound healing and scarring.
Analysis of the mouse embryonic stem cell regulatory networks obtained by ChIP-chip and ChIP-PET
Authors: Divya Mathur, Timothy W Danford, Laurie A Boyer, Richard A Young, David K Gifford, Rudolf Jaenisch
Journal: Genome biology (2008)

Genome-wide approaches have begun to reveal the transcriptional networks responsible for pluripotency in embryonic stem (ES) cells. Chromatin Immunoprecipitation (ChIP) followed either by hybridization to a microarray platform (ChIP-chip) or by DNA sequencing (ChIP-PET), has identified binding targets of the ES cell transcription factors OCT4 and NANOG in humans and mice, respectively. These studies have provided an outline of the transcriptional framework involved in maintaining pluripotency. Recent evidence with comparing multiple technologies suggests that expanding these datasets using different platforms would be a useful resource for examining the mechanisms underlying pluripotency regulation. We have now identified OCT4 and NANOG genomic targets in mouse ES cells by ChIP-chip and provided the means to compare these data with previously reported ChIP-PET results in mouse ES cells. We have mapped the sequences of OCT4 and NANOG binding events from each dataset to genomic coordinates, providing a valuable resource to facilitate a better understanding of the ES cell regulatory circuitry. Interestingly, although considerable differences are observed in OCT4 and NANOG occupancy as identified by each method, a substantial number of targets in both datasets are enriched for genes that have known roles in cell-fate specification and that are differentially expressed upon Oct4 or Nanog knockdown. This study suggests that each dataset is a partial representation of the overall ES cell regulatory circuitry, and through integrating binding data obtained by ChIP-chip and ChIP-PET, the methods presented here provide a useful means for integrating datasets obtained by different techniques in the future.
Therapeutic Targeting of <i>BRCA1</i>-Mutated Breast Cancers with Agents That Activate DNA Repair
Authors: Elizabeth Alli, David Solow-Cordero, Stephanie C. Casey, James M. Ford
Journal: Cancer Research (2014)

Cancers due to germline mutations in the BRCA1 gene tend to lack targets for approved chemoprevention agents. This study aimed at a targeted chemoprevention strategy for BRCA1-associated malignancies. Mutant BRCA1 limits the base-excision DNA repair activity that addresses oxidative DNA damage, the accumulation of which heightens one's risk for cancer. Therefore, we conducted a high-throughput chemical screen to identify drug candidates that could attenuate the inhibitory effects of mutant BRCA1 on this repair activity, thereby describing a new class of DNA repair-activating chemopreventive agents. In the screen design, such drugs functioned by enhancing base-excision DNA repair of oxidative DNA damage in the presence of mutant BRCA1, with minimal cytotoxicity. We identified at least one new agent that decreased malignant properties associated with tumorigenesis, including anchorage-independent growth and tumor progression. This work offers a preclinical proof-of-concept for a wholly new approach to chemoprevention in carriers of BRCA1 mutations as a strategy to reduce the prevalence of BRCA1-associated malignancy.
Cyclin E amplification/overexpression is associated with poor prognosis in gastric cancer
Authors: M. Alsina, S. Landolfi, C. Aura, K. Caci, J. Jimenez, L. Prudkin, S. Castro, D. Moreno, B. Navalpotro, J. Tabernero, M. Scaltriti
Journal: Annals of Oncology (2014)
Adverse effects of spinal manipulation: a systematic review
Authors: E Ernst
Journal: Journal of the Royal Society of Medicine (2007)

Objective To identify adverse effects of spinal manipulation. Design Systematic review of papers published since 2001. Setting Six electronic databases. Main outcome measures Reports of adverse effects published between January 2001 and June 2006. There were no restrictions according to language of publication or research design of the reports. Results The searches identified 32 case reports, four case series, two prospective series, three case-control studies and three surveys. In case reports or case series, more than 200 patients were suspected to have been seriously harmed. The most common serious adverse effects were due to vertebral artery dissections. The two prospective reports suggested that relatively mild adverse effects occur in 30% to 61 % of all patients. The case-control studies suggested a causal relationship between spinal manipulation and the adverse effect. The survey data indicated that even serious adverse effects are rarely reported in the medical literature. Conclusions Spinal manipulation, particularly when performed on the upper spine, is frequently associated with mild to moderate adverse effects. It can also result in serious complications such as vertebral artery dissection followed by stroke. Currently, the incidence of such events is not known. In the interest of patient safety we should reconsider our policy towards the routine use of spinal manipulation.
A ligand for peroxisome proliferator activated receptor gamma inhibits cell growth and induces apoptosis in human liver cancer cells
Authors: M Toyoda
Journal: Gut (2002)

Background and aims: Induction of apoptosis of cancer cells through ligands of nuclear hormone receptors (NHRs) is a new approach in cancer therapy. Recently, one of the NHRs, peroxisome proliferator activated receptor γ (PPARγ), has been shown to influence cell growth in certain cancer cells although its effect on hepatocellular carcinoma (HCC) has not been analysed. Methods: Experiments were conducted using three human liver cancer cell lines, PLC/PRF/5, Hep G2 and HuH-7, in vitro. These cells were exposed to troglitazone, a synthetic ligand for PPARγ, and the effects on cell growth were analysed. Results: Expression of PPARγ mRNA was detected in all three liver cancer cell lines. Activation of PPARγ by troglitazone caused a marked growth inhibition in a dose dependent manner in three hepatoma cell lines. The DNA fragmentation ELISA assay and Hoechst 33258 staining revealed that the growth inhibitory effect by adding troglitazone was due to apoptosis of PLC/PRF/5, which strongly expressed PPARγ. Troglitazone also induced activation of the cell death protease, caspase 3, but not caspase 8, in PLC/PRF/5 cells. However, expression levels of antiapoptotic factor bcl-2 and apoptosis inducing factor bax were not affected. Conclusion: Our study showed that PPARγ was expressed in human liver cancer cells and that the ligand for PPARγ, troglitazone, inhibited the growth of these cells by inducing apoptosis through caspase 3 activation, indicating that troglitazone could be potentially useful as an apoptosis inducer for the treatment of HCC.
Assessment of the skin penetration properties of different carrier vehicles for topically applied cortisol
Authors: P. J. W. AYRES, G. HOOPER
Journal: British Journal of Dermatology (1978)

Four commercially available topical preparations of cortisol, Alphaderm, Calmurid HC, Efcortelan and Topisone, had trace quantities of tritiated cortisol added to them. The resultant radiolabelled creams were applied to the dorsum of the pig and the penetration of the steroid was assessed. Alphaderm was shown to deliver approximately 16.0 times more cortisol to the skin than Topisone, approximately 8.0 times more than Efcortelan and approximately 3.0 times more than Calmurid HC.
Asymptomatic Peripheral Arterial Disease Is Associated With More Adverse Lower Extremity Characteristics Than Intermittent Claudication
Authors: Mary M. McDermott, Jack M. Guralnik, Luigi Ferrucci, Lu Tian, Kiang Liu, Yihua Liao, David Green, Robert Sufit, Frederick Hoff, Takashi Nishida, Leena Sharma, William H. Pearce, Joseph R. Schneider, Michael H. Criqui
Journal: Circulation (2008)

Background— This study assessed functional performance, calf muscle characteristics, peripheral nerve function, and quality of life in asymptomatic persons with peripheral arterial disease (PAD). Methods and Results— PAD participants (n=465) had an ankle brachial index &lt;0.90. Non-PAD participants (n=292) had an ankle brachial index of 0.90 to 1.30. PAD participants were categorized into leg symptom groups including intermittent claudication (n=215) and always asymptomatic (participants who never experienced exertional leg pain, even during the 6-minute walk; n=72). Calf muscle was measured with computed tomography. Analyses were adjusted for age, sex, race, ankle brachial index, comorbidities, and other confounders. Compared with participants with intermittent claudication, always asymptomatic PAD participants had smaller calf muscle area (4935 versus 5592 mm 2 ; P &lt;0.001), higher calf muscle percent fat (16.10% versus 9.45%; P &lt;0.001), poorer 6-minute walk performance (966 versus 1129 ft; P =0.0002), slower usual-paced walking speed ( P =0.0019), slower fast-paced walking speed ( P &lt;0.001), and a poorer Short-Form 36 Physical Functioning score ( P =0.016). Compared with an age-matched, sedentary, non-PAD cohort, always asymptomatic PAD participants had smaller calf muscle area (5061 versus 5895 mm 2 ; P =0.009), poorer 6-minute walk performance (1126 versus 1452 ft; P &lt;0.001), and poorer Walking Impairment Questionnaire speed scores (40.87 versus 57.78; P =0.001). Conclusions— Persons with PAD who never experience exertional leg symptoms have poorer functional performance, poorer quality of life, and more adverse calf muscle characteristics compared with persons with intermittent claudication and a sedentary, asymptomatic, age-matched group of non-PAD persons.
The Modulation of CD40 Ligand Signaling by Transmembrane CD28 Splice Variant in Human T Cells
Authors: Sebastian A. Mikolajczak, Bruce Y. Ma, Tetsuya Yoshida, Ryoko Yoshida, David J. Kelvin, Atsuo Ochi
Journal: The Journal of Experimental Medicine (2004)

The role of CD40 ligand (CD40L)/CD40 signaling in T cell–dependent B cell differentiation and maturation has been amply documented. The mechanism of CD40 signaling in B cells has been well established, whereas the signaling mechanism of CD40L in T cell costimulation remains unknown. In this study we show that CD28i, a transmembrane splice variant of CD28 costimulatory receptor, complexes with CD40L in human T cells. The cross-linking of CD40L resulted in the coendocytosis of CD28i with CD40L. The tyrosine phosphorylation of CD28i followed the cross-linking of CD40L, and the overexpression of CD28i augmented the c-Jun NH2-terminal kinase, p21-activated kinase 2, and nuclear factor κB activation. These data indicate that CD28i, by functioning as a signaling adaptor, transduces CD40L signaling as well as CD28 signaling in human T cells.
Acute myelomonocytic leukemia (AML‐M4) and translocation t(6;9) (p23;q34): Two additional patients with prominent myelodysplasia
Authors: Douglas E. Horsman, Dagmar K. Kalousek
Journal: American Journal of Hematology (1987)

Abstract Two patients with acute myelomonocytic leukemia (AML‐M 4 ) and a specific chromosomal translocation t(6;9)(p23;q34) are reported and compared to 21 AML patients with the same translocation collected from the literature. Our observations suggest that AML with t(6;9)(p23;q34) is characterized by myelodysplasia, basophilia, and a variety of blast cell morphologies (M 1 , M 2 , M 4 ) with a greater proportion of the cases than previously appreciated being examples of acute myelomonocytic leukemia (AML‐M 4 ). The consistent association of myelodysplasia provokes the proposal that this subtype of de novo AML is a result of an acute stem cell disorder. The poor outcome with standard AML chemotherapy experienced in this group of relatively young patients necessitates consideration of alternative therapeutic strategies such as early bone marrow transplantation.
Cell phone based physical activity monitoring: A validation study
Authors: Filippo Gravante, Emmanuel Stamatakis, David Prieto, Eleanor Main
Journal: European Respiratory Journal (2012)

Background  Accelerometers are accurate and useful for monitoring Physical Activity (PA) in people with chronic lung disease (eg. COPD) and can help motivate clients to comply with rehabilitation. However, they are expensive and largely limited to research. Similar motion sensors are embedded within the majority of newer mobile phones, which are widely accessible.  Aim  This study investigated whether the built-in accelerometers within mobile phones may be valid and reliable for monitoring PA.  Method  A mobile phone application to record real time tri-axial acceleration was developed. The accelerometer integrated within 2 mobile phones (HTC Wildfire and HTC Desire HD) was compared to a validated accelerometer (ActiGraph GT3X). Wearing all 3 devices, 7 healthy adults performed 7 different activities, paced with a metronome, each repeated 7 times. Absolute values of 3D acceleration signals were summed and averaged over each time period. Reliability was evaluated using Intra-class Correlation Coefficients (ICC). Concurrent validity was assessed using a general linear model for repeated measures (GLM) and Pearson correlation.  Results  The ICC for both phone devices ranged between 0.82 and 0.98. GLM and Pearson coefficient confirmed good correlation between phones and ActiGraph in all activities (Figure 1).  Conclusion  Mobile phone accelerometers appear to be reliable and valid for measuring PA. Further research is needed to confirm these data in a patient population.
Arsenic and Fluoride Exposure in Drinking Water: Children’s IQ and Growth in Shanyin County, Shanxi Province, China
Authors: San-Xiang Wang, Zheng-Hui Wang, Xiao-Tian Cheng, Jun Li, Zhi-Ping Sang, Xiang-Dong Zhang, Ling-Ling Han, Xiao-Yan Qiao, Zhao-Ming Wu, Zhi-Quan Wang
Journal: Environmental Health Perspectives (2007)

Recently, in a cross-sectional study of 201 children in Araihazar, Bangladesh, exposure to arsenic (As) in drinking water has been shown to lower the scores on tests that measure children's intellectual function before and after adjustment for sociodemographic features.We investigated the effects of As and fluoride exposure on children's intelligence and growth.We report the results of a study of 720 children between 8 and 12 years of age in rural villages in Shanyin county, Shanxi province, China. The children were exposed to As at concentrations of 142 +/- 106 microg/L (medium-As group) and 190 +/- 183 microg/L (high-As group) in drinking water compared with the control group that was exposed to low concentrations of As (2 +/- 3 microg/L) and low concentrations of fluoride (0.5 +/- 0.2 mg/L). A study group of children exposed to high concentrations of fluoride (8.3 +/- 1.9 mg/L) but low concentrations of As (3 +/- 3 microg/L) was also included because of the common occurrence of elevated concentrations of fluoride in groundwater in our study area. A standardized IQ (intelligence quotient) test was modified for children in rural China and was based on the classic Raven's test used to determine the effects of these exposures on children's intelligence. A standardized measurement procedure for weight, height, chest circumference, and lung capacity was used to determine the effects of these exposures on children's growth.The mean IQ scores decreased from 105 +/- 15 for the control group, to 101 +/- 16 for the medium-As group (p < 0.05), and to 95 +/- 17 for the high-As group (p < 0.01). The mean IQ score for the high-fluoride group was 101 +/- 16 and significantly different from that of the control group (p < 0.05). Children in the control group were taller than those in the high-fluoride group (p < 0.05); weighed more than the those in the high-As group (p < 0.05); and had higher lung capacity than those in the medium-As group (p < 0.05).Children's intelligence and growth can be affected by high concentrations of As or fluoride. The IQ scores of the children in the high-As group were the lowest among the four groups we investigated. It is more significant that high concentrations of As affect children's intelligence. It indicates that arsenic exposure can affect children's intelligence and growth.
Axillary Treatment in Conservative Management of Operable Breast Cancer: Dissection or Radiotherapy? Results of a Randomized Study With 15 Years of Follow-Up
Authors: Christine Louis-Sylvestre, Krishna Clough, Bernard Asselain, Jacques René Vilcoq, Remy Jacques Salmon, François Campana, Alain Fourquet
Journal: Journal of Clinical Oncology (2003)

Purpose Axillary dissection is the standard management of the axilla in invasive breast carcinoma. This surgery is responsible for functional sequelae and some options are considered, including axillary radiotherapy. In 1992, we published the initial results of a prospective randomized trial comparing lumpectomy plus axillary radiotherapy versus lumpectomy plus axillary dissection. We present an update of this study with a median follow-up of 180 months (range, 12 to 221 months). Patients and Methods Between 1982 and 1987, 658 patients with a breast carcinoma less than 3 cm in diameter and clinically uninvolved lymph nodes were randomly assigned to axillary dissection or axillary radiotherapy. All patients underwent wide excision of the tumor and breast irradiation. Results The two groups were similar for age, tumor-node-metastasis system stage, and presence of hormonal receptors; 21% of the patients in the axillary dissection group were node-positive. Our initial results showed an increased survival rate in the axillary dissection group at 5 years (P = .009). At 10 and 15 years, however, survival rates were identical in both groups (73.8% v 75.5% at 15 years). Recurrences in the axillary node were less frequent in the axillary dissection group at 15 years (1% v 3%; P = .04). There was no difference in recurrence rates in the breast or supraclavicular and distant metastases between the two groups. Conclusion In early breast cancers with clinically uninvolved lymph nodes, our findings show that long-term survival does not differ after axillary radiotherapy and axillary dissection. The only difference is a better axillary control in the group with axillary dissection.
Gene Therapy Strategy for Long-Term Myocardial Protection Using Adeno-Associated Virus-Mediated Delivery of Heme Oxygenase Gene
Authors: Luis G. Melo, Reitu Agrawal, Lunan Zhang, Mojgan Rezvani, Abeel A. Mangi, Afshin Ehsan, Daniel P. Griese, Giorgio Dell’Acqua, Michael J. Mann, Junichi Oyama, Shaw-Fang Yet, Matthew D. Layne, Mark A. Perrella, Victor J. Dzau
Journal: Circulation (2002)

Ischemia and oxidative stress are the leading mechanisms for tissue injury. An ideal strategy for preventive/protective therapy would be to develop an approach that could confer long-term transgene expression and, consequently, tissue protection from repeated ischemia/reperfusion injury with a single administration of a therapeutic gene. In the present study, we used recombinant adeno-associated virus (rAAV) as a vector for direct delivery of the cytoprotective gene heme oxygenase-1 (HO-1) into the rat myocardium, with the purpose of evaluating this strategy as a therapeutic approach for long-term protection from ischemia-induced myocardial injury.Human HO-1 gene (hHO-1) was delivered to normal rat hearts by intramyocardial injection. AAV-mediated transfer of the hHO-1 gene 8 weeks before acute coronary artery ligation and release led to a dramatic reduction (>75%) in left ventricular myocardial infarction. The reduction in infarct size was accompanied by decreases in myocardial lipid peroxidation and in proapoptotic Bax and proinflammatory interleukin-1beta protein abundance, concomitant with an increase in antiapoptotic Bcl-2 protein level. This suggested that the transgene exerts its cardioprotective effects in part by reducing oxidative stress and associated inflammation and apoptotic cell death.This study documents the beneficial therapeutic effect of rAAV-mediated transfer, before myocardial injury, of a cytoprotective gene that confers long-term myocardial protection from ischemia/reperfusion injury. Our data suggest that this novel "pre-event" gene transfer approach may provide sustained tissue protection from future repeated episodes of injury and may be beneficial as preventive therapy for patients with or at risk of developing coronary ischemic events.