tbuckley/cabot-search huggingface dataset:
Costs in Veterans Administration Hospitals
Authors: Judith H. Jameson, C. Rodney Baker, Roberta A. Monson
Journal: Annals of Internal Medicine (1980)

Letters and Corrections1 November 1980Costs in Veterans Administration HospitalsJUDITH H. JAMESON, M.P.H., C. RODNEY BAKER, M.D., ROBERTA A. MONSON, M.D.JUDITH H. JAMESON, M.P.H.Search for more papers by this author, C. RODNEY BAKER, M.D.Search for more papers by this author, ROBERTA A. MONSON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-93-5-782 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Undoubtedly "The Cost of Outpatient Physicians' Services at a Veterans Administration Hospital" (1) will fuel the arguments against federally sponsored health care. Although we should applaud this effort to identify outpatient costs in the Veterans Administration (VA), we should regard the cost figures themselves with a great deal of caution. There are serious problems in the methods used by Reilly and Reilly. Their errors probably lead to a sizable overestimate of the cost, especially in the areas of salaries and supplies. These areas together account for 76.5% of their estimate.The authors...Reference1. REILLYREILLY PM. The cost of outpatient physicians' services at a Veterans Administration hospital. Ann Intern Med. 1980;93(Part 1):128-32. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMore or Less?Is Long-Term Antithyroid Drug Therapy for Graves’ Disease Cost-Effective? 1 November 1980Volume 93, Issue 5Page: 782-784KeywordsHealth careOutpatient clinicsOutpatientsVeteran care Issue Published: 1 November 1980 PDF downloadLoading ...
Essential Roles for GSK-3s and GSK-3-Primed Substrates in Neurotrophin-Induced and Hippocampal Axon Growth
Authors: Woo-Yang Kim, Feng-Quan Zhou, Jiang Zhou, Yukako Yokota, Yan-Min Wang, Takeshi Yoshimura, Kozo Kaibuchi, James R. Woodgett, E.S. Anton, William D. Snider
Journal: Neuron (2006)
Pouchitis: result of microbial imbalance?
Authors: J G Ruseler-van Embden, W R Schouten, L M van Lieshout
Journal: Gut (1994)

To elucidate the role of microbiological factors in pouchitis, this study investigated the composition of ileal reservoir microflora, the mucus degrading capacity of bacterial enzymes as well as the pH and the proteolytic activity of pouch effluent. Stool samples were collected from five patients with pouchitis and nine patients without pouchitis. The flora of patients with pouchitis had an increased number of aerobes, a decreased ratio anaerobes to aerobes, less bifidobacteria and anaerobic lactobacilli, more Clostridium perfringens, and several species that were not found in control patients (for example, fungi). Furthermore the pH was significantly higher in patients with pouchitis (median value 6.5) than in control patients (5.4). To find out if the pH might influence the breakdown of intestinal mucus glycoproteins, the activity of glycosidases and proteases, and the degradation of hog gastric mucin by the pouch flora was tested at pH 5.2-7.6. Some glycosidases were inhibited, others were stimulated by a low pH, however, in each sample the proteolytic activity was inhibited for 75% at pH 5.2 compared with pH 6.8 and 7.6. Degradation of hog gastric mucin by the pouch flora was an active process at pH 7.2: within two to four hours of incubation more than half of the mucin was degraded. At pH 5.2 it took twice as long. It is concluded that pouchitis possibly results from instability of the flora in the pouch, which causes homeostasis to disappear (dysbiosis), and the protection of the pouch epithelium by the mucus layer becomes affected by increased activity of bacterial and host derived enzymes.
The Effects of Early-Life Environmental Tobacco Smoke (ETS) Exposure on Pet Allergy at Age 18 in the Childhood Allergy Study
Authors: C.C. Linden, G. Wegienka, S. Havstad, D.R. Ownby, C.C. Johnson, R.T. Misiak, E.M. Zoratti
Journal: Journal of Allergy and Clinical Immunology (2009)
917-100 8-Epi-Prostaglandin F 2α (8-Isoprostane), a Novel Marker of Lipid Peroxidation, is Elevated and Inversely Correlated to Serum Antioxidant Vitamins in Smokers
Authors: Emile R. Mohler, Pam McClelland, David R. Hathaway, Peter Reaven
Journal: Journal of the American College of Cardiology (1995)
HbA1c Measurements Do Not Improve the Detection of Type 2 Diabetes in a Randomly Selected Population
Authors: Mayer B. Davidson, David L. Schriger, Brett Lorber
Journal: Diabetes Care (2001)

Perry et al. (1) compared the sensitivity of fasting plasma glucose (FPG) concentrations and HbA1c levels to diagnose diabetes in high-risk subjects whose 2-h glucose concentrations on an oral glucose tolerance test (OGTT) exceeded 11.1 mmol/l (200 mg/dl) and therefore met the OGTT criterion for diabetes (2). A total of 950 subjects with the following high-risk parameters were recruited: 1 ) obesity (BMI ≥24 kg/m2), 2 ) a family history of diabetes, and 3 ) individuals who had been told that they had “a touch of sugar,” “borderline diabetes,” or “glucose intolerance.” Of these subjects, 244 had FPG concentrations between 5.5 and 8.0 mmol/l (99 and 144 mg/dl) and underwent an OGTT. Of the 121 subjects with OGTT-diagnosed diabetes, 101 had complete data that also included FPG and HbA1c values; 45% had …
Angina Pectoris Without Chest Pain
Authors: Shlomo Stern
Journal: Circulation (2002)

e may never know whether the accuracy of William Heberden's description in the 1770s of a new syndrome, centering around pain in the left chest and named by him "angina pectoris," occurred because the author himself experienced the symptoms described. 1Heberden's description of the symptoms has prevailed for centuries, as if it were written in stone.Decades later, this "pain in the chest" was clarified as being induced by myocardial ischemia at the time the patient experiences the pain.Only rarely over the centuries and usually only through anecdotal cases did the medical literature report that ischemia can be present without accompanying pain in the chronic situation of angina pectoris or even during an acute myocardial infarction.4][5] These studies prompted new investigations on the syndrome that is now called silent myocardial ischemia.
Neonatal neutrophil inflammatory responses: Parallel studies of light scattering, cell polarization, chemotaxis, superoxide release, and bactericidal activity
Authors: B. Wolach, D. Sonnenschein, R. Gavrieli, O. Chomsky, A. Pomeranz, I. Yuli
Journal: American Journal of Hematology (1998)

Neutrophil dysfunction among newborn infants, especially those born prematurely, is well recognized, but the mechanism responsible for this phenomenon is yet to be clarified.In this study, we evaluated the stimulus response coupling in neutrophils from 90 healthy newborns and 96 healthy adults in an effort to establish whether defective neonatal neutrophil function is a result of impaired signal perception or immature responsiveness.Measurement of rapid-and slow-light scattering responses (LSR) to 1 µM FMLP stimulation revealed that neonatal neutrophils have about one-half the corresponding responsiveness of adult cells (rapid-LSR: 6.1 ± 3.1 arbitrary light intensity units vs. 12.0 ± 2.8, P < .001;and slow-LSR: 5.0 ± 2.5 vs. 9.1 ± 2.0; P < .001).The same markedly reduced activity was observed in newborn neutrophil chemotaxis and bactericidal activity in comparison with adult cells.Nevertheless, low FMLP concentrations (less than 1 nM) induced no difference in cell polarization between newborn and adult neutrophils, yet at higher FMLP concentrations, the newborn revealed significantly reduced cell polarization.Our data suggest that newborn infants bear a fully functional FMLP signal perception but lack the full capacity of inflammatory responsiveness.
HIV and Infant Feeding—An Ongoing Challenge
Authors: Laura A. Guay, Andrea J. Ruff
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Evolution of Stigmata of Hemorrhage in Bleeding Peptic Ulcers: A Sequential Endoscopic Study
Authors: J. Y. W. Lau, S. C. S. Chung, J. W. Leung, K. K. Lo, M. Y. Yung, A. K. C. Li
Journal: Endoscopy (1998)

Stigmata of hemorrhage in bleeding peptic ulcers have prognostic characteristics. In the present study, the evolution of these stigmata was studied prospectively using daily endoscopic examinations.From January 1989 to October 1989, 778 consecutive patients with bleeding peptic ulcers underwent endoscopy within 24 hours of admission. The bleeding peptic ulcers were assigned by three endoscopists to five categories, those with: a) active bleeding, b) a nonbleeding visible vessel, c) adherent clot, d) dot, or e) a clean base. Actively bleeding ulcers were treated by epinephrine injection. Ulcers with nonbleeding visible vessels, adherent clots, or dots were left untreated. Daily endoscopic examinations were carried out for three subsequent days, or until the ulcer base became clean.On day 0, there were 56 actively bleeding ulcers (7%), 62 ulcers with visible vessels (8%), 104 with adherent clots (13%), 182 with flat dots (23%), and 374 with a white base (48%). On the subsequent three days, 24 of 62 ulcers with visible vessels (39%), 30 of 104 with adherent clots (29%), 24 of 182 with dots (13%), and 19 of 374 with a clean base (5%) on day 0 re-bled endoscopically or clinically, or both. The overall rebleeding risk was 9.9%, 4.9%, and 2.7% on days 1, 2, and 3, respectively.Stigmata of hemorrhage in bleeding peptic ulcers are predictive of rebleeding. They represent intermediate phases in the evolution of bleeding vessels into clean-based ulcers. The associated rebleeding risk diminishes as the vessel disappears from the ulcer base.
The legless dual support system and the new dawn.
Authors: R Smith
Journal: BMJ (1987)

The  support  is one of those pieces of jargon (rather like the  for knock agreement) that rolls easily off the tongue but is nothing more than a phrase to many people. The system hinges on the way in which university research is supported by  the universities themselves and external sources of funding, with the research councils (until recently) being the main source. The Advisory Board for the Research Councils (ABRC) in its recent policy document, A Strategy for the Science Base,1 described the dual support system as both imperfectly understood and under considerable strain and included in the document a report on the system that it had joindy prepared with the University Grants Committee (UGC). Ironically this document may prove to have been one of the important milestones in the destruction of the system because one of the options it discusses is removing the university funding for research and giving the money to the research councils. It has been forced to consider what would be a funda? mental change in the system by the extreme ricketiness of the dual support system, which in many places has collapsed completely.
Simulation studies of the electrocardiogram. I. The normal heart.
Authors: W T Miller, D B Geselowitz
Journal: Circulation Research (1978)

A digital computer model is presented for the simulation of the body surface electrocardiogram (ECG) during ventricular activation and recovery. The ventricles of the heart are represented in detail by a three-dimensional array of approximately 4000 points which is subdivided into 23 regions. Excitation sequence and cellular action potential data taken from the literature are used to determine the spatial distribution of intracellular potentials at each instant of time during a simulated cardiac cycle. The moment of the single dipole representing each region is determined by summing the spatial gradient of the intracellular potential distribution throughout the region. The resulting set of 23 dipoles is then used to calculate the potentials on the surface of a bounded homogeneous volume conductor with the shape of an adult torso. Simulated isopotential surface maps during both activation and recovery are in good agreement with data for humans reported in the literature.
Ionizing Radiation and Chronic Lymphocytic Leukemia
Authors: David B. Richardson, Steve Wing, Jane Schroeder, Inge Schmitz-Feuerhake, Wolfgang Hoffmann
Journal: Environmental Health Perspectives (2004)

The U.S. government recently implemented rules for awarding compensation to individuals with cancer who were exposed to ionizing radiation while working in the nuclear weapons complex. Under these rules, chronic lymphocytic leukemia (CLL) is considered to be a nonradiogenic form of cancer. In other words, workers who develop CLL automatically have their compensation claim rejected because the compensation rules hold that the risk of radiation-induced CLL is zero. In this article we review molecular, clinical, and epidemiologic evidence regarding the radiogenicity of CLL. We note that current understanding of radiation-induced tumorigenesis and the etiology of lymphatic neoplasia provides a strong mechanistic basis for expecting that ionizing radiation exposure increases CLL risk. The clinical characteristics of CLL, including prolonged latency and morbidity periods and a low case fatality rate, make it relatively difficult to evaluate associations between ionizing radiation and CLL risk via epidemiologic methods. The epidemiologic evidence of association between external exposure to ionizing radiation and CLL is weak. However, epidemiologic findings are consistent with a hypothesis of elevated CLL mortality risk after a latency and morbidity period that spans several decades. Our findings in this review suggest that there is not a persuasive basis for the conclusion that CLL is a nonradiogenic form of cancer.
Squamous cell carcinoma arising in a patient with long-standing pansclerotic morphea
Authors: P.C. Parodi, C. Riberti, D. Draganic Stinco, P. Patrone, G. Stinco
Journal: British Journal of Dermatology (2001)

Sir, Disabling pansclerotic morphea of children is a rare and very serious type of morphoea.1 It usually appears before the age of 4 years. The sclerosis affects the dermis, adipose tissue, fascia, muscle and even bone. It affects the trunk, extremities, scalp and face, sparing fingertips and toes. The sclerotic skin of the limbs ulcerates easily. Patients suffer from intense pain due to the involvement of joints and nerves. In general there is no systemic involvement but in some cases oesophageal, pulmonary and periodontal alterations have been reported. Treatment is ineffective, although immunosuppressive drugs and UVA‐1 phototherapy and PUVA therapy can slow the course of the disease.2,3 We report the case of a young patient affected by this rare disease who died because of the rapid spread of squamous cell carcinoma (SCC) on sclerodermatous tissue. A 20‐year‐old man in good general condition presented with a 15 cm ulcer on the lower 2/3 of his left leg (Fig. 1a). The lesion was hard, with an irregular surface covered by slough and had irregular margins 2 cm higher than the surrounding sclerodermatous skin. Another ulcer of 5 cm diameter, not very deep, with irregular, sloping margins and sloughy base, surrounded by sclerodermatous skin, was present on the right leg. There were other sclerodermatous patches on his limbs, with subcutaneous calcification, marked muscular atrophy and a flexion contractures of the elbow, wrists and knee joints. There were also numerous sclerotic patches on his trunk and a sclero‐atrophic alopecia in the right temporal–parietal region. The patient had been affected by scleroderma from the age of 2 years; ulcers had formed for the first time on sclerotic patches on his limbs at age 5 years. When he was 19 years old, 8 months before he was examined by us, the patient had noticed the onset of a new ulcer that was progressively increasing in size in the left pretibial region. The patient was used to having similar lesions and applied local antiseptic medications for several months. When the lesion reached 7 cm diameter, 7 months after its onset, it was biopsied and the histological examination showed a moderately differentiated SCC (Fig. 1b). Biopsy performed a month later, when he presented to us, showed that the cancerous tissue had infiltrated the underlying muscle. Because of the size of the tumour, below‐knee amputation was performed. Five months later the patient died because the tumour had spread to the lungs, heart, kidneys, liver and spleen.
Evaluating the Antirheumatic Drugs
Authors: SANFORD H. ROTH
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 October 1986Evaluating the Antirheumatic DrugsSANFORD H. ROTH, M.D.SANFORD H. ROTH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-105-4-632_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The Food and Drug Administration (FDA) has just reported the completion of the first revision of guidelines for the clinical evaluation of nonsteroidal anti-inflammatory and antirheumatic drugs (for adults and children) since the guidelines were first proposed in 1967. This marks the culmination of a unique ad hoc group interaction of the FDA, industry, and academic departments of rheumatology and is the result of an ongoing series of extramural meetings previously reported in Annals (1, 2). This document, when published, will provide updated guidelines for more efficient and statistically appropriate assessment of anti-inflammatory drugs and, for the...References1. ROTHMACKENZIE SA. Drug development, guidelines, and the Food and Drug Administration [Editorial]. Ann Intern Med. 1984;101:125-7. LinkGoogle Scholar2. ROTH S. Guidelines on new anti-rheumatic drugs [Letter]. Ann Intern Med. 1986;104:288. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Anti-Rheumatic Drug Guidelines Group 525 North 18th Street; Phoenix, AZ 85006 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1986Volume 105, Issue 4Page: 632-632KeywordsChildrenDrug administrationDrugsFood and Drug AdministrationRheumatology Issue Published: 1 October 1986 PDF DownloadLoading ...
Synergistic Antitumor Effects of Doxorubicin‐Loaded Carboxymethyl Cellulose Nanoparticle in Combination with Endostar for Effective Treatment of Non‐Small‐Cell Lung Cancer
Authors: Mingqiang Li, Zhaohui Tang, Jian Lin, Yu Zhang, Shixian Lv, Wantong Song, Yubin Huang, Xuesi Chen
Journal: Advanced Healthcare Materials (2014)

The multi‐modal combination therapy is proved powerful and successful to enhance the antitumor efficacy in clinics as compared with single therapy modes. In this study, the potential of combining chemotherapy with antiangiogenic therapy for the treatment of non‐small‐cell lung cancer is explored. Towards this aim, OEGylated carboxymethyl cellulose–(2‐(2‐(2‐methoxyethoxy)ethoxy)methyl)oxirane (CMC–ME 2 MO) is prepared by treating CMC with ME 2 MO in the alkaline aqueous solution, and used to efficiently carry doxorubicin (DOX) with high drug‐loading content (16.64%) and encapsulation efficiency (99.78%). As compared to free DOX, the resulting nanoparticles show not only the favorable stability in vitro but also the prolonged blood circulation, improved safety and tolerability, optimized biodistribution, reduced systemic toxicity, and enhanced antitumor efficacy in vivo, indicates a potential utility in cancer chemotherapy. Furthermore, the combination of the DOX‐loaded polysaccharide nanoparticles and antiangiogenic drug endostar provides synergistic effects of chemotherapy and antiangiogenic therapy, which shows the highest efficiency in tumor suppression. The combination approach of the DOX‐containing nanomedicine and endostar for efficient treatment of non‐small‐cell lung cancer is first proposed to demonstrate the synergistic therapeutic effect. This synergistic combination proves to be a promising therapeutic regimen in cancer therapy and holds great potential for clinical application.
Protection of Endothelial Cells by Dextran Sulfate in Rats with Thrombotic Microangiopathy
Authors: Nobuaki Eto, Ichiro Kojima, Noriko Uesugi, Reiko Inagi, Toshio Miyata, Toshiro Fujita, Richard J. Johnson, Stuart J. Shankland, Masaomi Nangaku
Journal: Journal of the American Society of Nephrology (2005)

The characteristic features of thrombotic microangiopathy (TMA) include glomerular and peritubular capillary endothelial cell injury in association with loss of heparan sulfate proteoglycans on the cell surface and thrombus formation, followed by subsequent ischemic tubulointerstitial damage. It therefore was hypothesized that dextran sulfate (DXS) may protect the kidney against endothelial damage in a model of TMA. TMA was induced in rats by renal artery perfusion of an antiglomerular endothelial antibody, followed by the administration of DXS or vehicle. Renal damage was assessed by histologic analysis and measurements of blood urea nitrogen and creatinine. Whereas control rats developed severe renal failure with extensive glomerular and tubular injury, administration of DXS significantly protected renal function and preserved the glomerular endothelium and peritubular capillaries. The beneficial effect of DXS could be attributed to the ability of DXS to protect endothelial cells from coagulation and complement activation, as demonstrated by the histologic analysis. In addition, binding of the administered DXS to the surface of the glomerular endothelium was confirmed in TMA rats, suggesting that DXS acts as a "repair coat" of injured glomerular endothelium. In conclusion, DXS protects the kidney from experimental TMA. This protection may be mediated by DXS's binding directly to the surface of glomerular endothelium and amelioration of coagulation, complement activation, and cellular matrix loss.
Notes of a Case of Weil's Disease
Authors: W. B. Miller
Journal: BMJ (1889)

anatomy of the prostate, it is stated that its muscular power appears to have been exaggerated, and exception is taken to the conclusions drawn in reference to this point by Professor Viner Ellis.4It seems difficult to reconcile Mr. Griffiths' views with such illustrations as I have ventured to draw from the practice of surgery bearing upon the function of this part.