Is There Something Special about Low-Carbohydrate Diets?
Authors: George A. Bray
Journal: Annals of Internal Medicine (2005)

Editorials15 March 2005Is There Something Special about Low-Carbohydrate Diets?George A. Bray, MDGeorge A. Bray, MDFrom Pennington Biomedical Research Center, Baton Rouge, LA 70808.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-142-6-200503150-00013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Obesity is increasing rapidly and has been called an epidemic by the World Health Organization and the National Heart, Lung, and Blood Institute (1, 2). Controlling this epidemic will require an integrated strategy, including education, regulation by appropriate state and federal agencies, and modifications in food supply (3, 4). Regardless of the effectiveness of preventive strategies, some individuals will develop an unhealthy weight, reflected in a high body mass index (BMI), and will need treatment. Dietary strategies, exercise, and behavioral therapy are the cornerstones of current treatment. In this issue, Boden and colleagues (5) extend the list of studies dealing ...References1. Obesity: preventing and managing the global epidemic. Report of a WHO consultation. World Health Organ Tech Rep Ser. 2000;894:i-xii, 1-253. [PMID: 11234459] MedlineGoogle Scholar2. Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults—The Evidence Report. National Institutes of Health. Obes Res. 1998;6 Suppl 2 51S-209S. [PMID: 9813653] MedlineGoogle Scholar3. Bray GA, Champagne CM. Beyond energy balance: there's more to obesity than calories. J Am Diet Assoc. 2005. [In press]. Google Scholar4. Diet, Nutrition and the Prevention of Chronic Diseases: Report of a Joint WHO/FAO Expert Consultation. WHO Technical Report Series 916. Geneva: World Health Organization; 2003. Google Scholar5. Boden G, Sargrad K, Homko C, Mozzoli M, Stein TP. Effect of a low-carbohydrate diet on appetite, blood glucose levels, and insulin resistance in obese patients with type 2 diabetes. Ann Intern Med. 2005;142:403-11. LinkGoogle Scholar6. Banting W. Letter on Corpulence, Addressed to the Public. 3rd ed. Philadelphia: Lippincott; 1864. Google Scholar7. Atkins RC. Dr. Atkins' Diet Revolution. New York: Bantam; 1972. Google Scholar8. Freedman MR, King J, Kennedy E. Popular diets: a scientific review. Obes Res. 2001;9 Suppl 1 1S-40S. [PMID: 11374180] CrossrefMedlineGoogle Scholar9. Dansinger ML, Gleason JA, Griffith JL, Selker HP, Schaefer EJ. Comparison of the Atkins, Ornish, Weight Watchers, and Zone diets for weight loss and heart disease risk reduction: a randomized trial. JAMA. 2005;293:43-53. [PMID: 15632335] CrossrefMedlineGoogle Scholar10. Rolls BJ, Pirraglia PA, Jones MB, Peters JC. Effects of olestra, a noncaloric fat substitute, on daily energy and fat intakes in lean men. Am J Clin Nutr. 1992;56:84-92. [PMID: 1609767] CrossrefMedlineGoogle Scholar11. Bray GA, Lovejoy JC, Most-Windhauser M, Smith SR, Volaufova J, Denkins Y, et al. A 9-mo randomized clinical trial comparing fat-substituted and fat-reduced diets in healthy obese men: the Ole Study. Am J Clin Nutr. 2002;76:928-34. [PMID: 12399262] CrossrefMedlineGoogle Scholar12. Bell EA, Roe LS, Rolls BJ. Sensory-specific satiety is affected more by volume than by energy content of a liquid food. Physiol Behav. 2003;78:593-600. [PMID: 12782213] CrossrefMedlineGoogle Scholar13. Kinsell LW, Gunning B, Michaels GD, Richardson J, Cox SE, Lemon C. Calories do count. Metabolism. 1964;13:195-204. [PMID: 14127686] CrossrefMedlineGoogle Scholar14. Lyon XH, Di Vetta V, Milon H, Jéquier E, Schutz Y. Compliance to dietary advice directed towards increasing the carbohydrate to fat ratio of the everyday diet. Int J Obes Relat Metab Disord. 1995;19:260-9. [PMID: 7627250] MedlineGoogle Scholar15. Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA, et al. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med. 2002;346:393-403. [PMID: 11832527] CrossrefMedlineGoogle Scholar16. Foster GD, Wyatt HR, Hill JO, McGuckin BG, Brill C, Mohammed BS, et al. A randomized trial of a low-carbohydrate diet for obesity. N Engl J Med. 2003;348:2082-90. [PMID: 12761365] CrossrefMedlineGoogle Scholar17. Stern L, Iqbal N, Seshadri P, Chicano KL, Daily DA, McGrory J, et al. The effects of low-carbohydrate versus conventional weight loss diets in severely obese adults: one-year follow-up of a randomized trial. Ann Intern Med. 2004;140:778-85. [PMID: 15148064] LinkGoogle Scholar18. Brehm BJ, Seeley RJ, Daniels SR, D'Alessio DA. A randomized trial comparing a very low carbohydrate diet and a calorie-restricted low fat diet on body weight and cardiovascular risk factors in healthy women. J Clin Endocrinol Metab. 2003;88:1617-23. [PMID: 12679447] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: George A. Bray, MDAffiliations: From Pennington Biomedical Research Center, Baton Rouge, LA 70808.Disclosures: None disclosed.Corresponding Author: George A. Bray, MD, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808; e-mail, [email protected]edu. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoEffect of a Low-Carbohydrate Diet on Appetite, Blood Glucose Levels, and Insulin Resistance in Obese Patients with Type 2 Diabetes Guenther Boden , Karin Sargrad , Carol Homko , Maria Mozzoli , and T. Peter Stein Metrics Cited byLow-carbohydrate diets affect energy balance and fuel homeostasis differentially in lean and obese ratsDiets, Health, and Weight Control: What Do We Know?Lipoproteins in Diabetes: Risk and Opportunity 15 March 2005Volume 142, Issue 6Page: 469-470KeywordsBody weightCarbohydratesDietEatingExercise therapyFatsFoodObesityProteinsWeight loss ePublished: 15 March 2005 Issue Published: 15 March 2005 Copyright & PermissionsCopyright © 2005 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...