Vaccine-Associated Measles Pneumonitis in an Adult with AIDS
Authors: Jonathan B. Angel
Journal: Annals of Internal Medicine (1998)

Brief Communications15 July 1998Vaccine-Associated Measles Pneumonitis in an Adult with AIDSJonathan B. Angel, MD, Pramila Walpita, PhD, Robert A. Lerch, PhD, Mohinderjit S. Sidhu, PhD, Malthi Masurekar, PhD, Ronald A. DeLellis, MD, James T. Noble, MD, David R. Syndman, MD, and Stephen A. Udem, MD, PhDJonathan B. Angel, MDFrom Tufts University School of Medicine and New England Medical Center, Boston, Massachusetts; New Jersey Medical School, Newark, New Jersey; and Wyeth-Lederle Vaccines & Pediatrics, Pearl River, New York., Pramila Walpita, PhDFrom Tufts University School of Medicine and New England Medical Center, Boston, Massachusetts; New Jersey Medical School, Newark, New Jersey; and Wyeth-Lederle Vaccines & Pediatrics, Pearl River, New York., Robert A. Lerch, PhDFrom Tufts University School of Medicine and New England Medical Center, Boston, Massachusetts; New Jersey Medical School, Newark, New Jersey; and Wyeth-Lederle Vaccines & Pediatrics, Pearl River, New York., Mohinderjit S. Sidhu, PhDFrom Tufts University School of Medicine and New England Medical Center, Boston, Massachusetts; New Jersey Medical School, Newark, New Jersey; and Wyeth-Lederle Vaccines & Pediatrics, Pearl River, New York., Malthi Masurekar, PhDFrom Tufts University School of Medicine and New England Medical Center, Boston, Massachusetts; New Jersey Medical School, Newark, New Jersey; and Wyeth-Lederle Vaccines & Pediatrics, Pearl River, New York., Ronald A. DeLellis, MDFrom Tufts University School of Medicine and New England Medical Center, Boston, Massachusetts; New Jersey Medical School, Newark, New Jersey; and Wyeth-Lederle Vaccines & Pediatrics, Pearl River, New York., James T. Noble, MDFrom Tufts University School of Medicine and New England Medical Center, Boston, Massachusetts; New Jersey Medical School, Newark, New Jersey; and Wyeth-Lederle Vaccines & Pediatrics, Pearl River, New York., David R. Syndman, MDFrom Tufts University School of Medicine and New England Medical Center, Boston, Massachusetts; New Jersey Medical School, Newark, New Jersey; and Wyeth-Lederle Vaccines & Pediatrics, Pearl River, New York., and Stephen A. Udem, MD, PhDFrom Tufts University School of Medicine and New England Medical Center, Boston, Massachusetts; New Jersey Medical School, Newark, New Jersey; and Wyeth-Lederle Vaccines & Pediatrics, Pearl River, New York.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-129-2-199807150-00007 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The United States last encountered a measles epidemic in the late 1980s, a time when HIV infection was rapidly penetrating urban centers. The coincidence of these epidemics prompted reappraisal of the long-standing proscription against the use of live-virus vaccine in immunocompromised patients. Recognizing the severity of measles infection, particularly in patients with cell-mediated immune dysfunction [1-5], the Advisory Committee on Immunization Practices (ACIP) revised its measles vaccination guidelines in 1988. They began to recommend that 12- to 15-month-old children with asymptomatic HIV infection be vaccinated and that vaccination be considered for symptomatic HIV-infected children [1]. Many HIV-infected children have since ...References1. Immunization of children infected with human immunodeficiency virus-supplementary ACIP statement. Immunization Practices Advisory Committee. MMWR Morb Mortal Wkly Rep. 1988; 37:181-3. Google Scholar2. Measles in HIV-infected children, United States. MMWR Morb Mortal Wkly Rep. 1988; 37:183-6. Google Scholar3. Measles in HIV-infected children, United States. MMWR Morb Mortal Wkly Rep. 1988; 37:2352-7. Google Scholar4. Kaplan LJ, Daum RS, Smaron M, McCarthy CA. Severe measles in immunocompromised patients. JAMA. 1992; 267:1237-41. Google Scholar5. Palumbo P, Hoyt L, Demasio K, Oleske J, Connor E. Population-based study of measles and measles immunization in human immunodeficiency virus-infected children. Pediatr Infect Dis J. 1992; 11:1008-14. Google Scholar6. Onorato IM, Markowitz LE, Oxtoby MJ. Childhood immunization, vaccine-preventable diseases and infection with human immunodeficiency virus. Pediatr Infect Dis J. 1988; 7:588-95. Google Scholar7. McLaughlin M, Thomas P, Onorato I, Rubinstein A, Oleske J, Nicholas S, et al. Live virus vaccines in human immunodeficiency virus-infected children: a retrospective survey. Pediatrics. 1988; 82:229-33. Google Scholar8. Mori T, Sasaki K, Hashimoto H, Makino S. Molecular cloning and complete nucleotide sequence of genomic RNA of the AIK-C strain of attenuated measles virus. Virus Genes. 1993; 7:67-81. Google Scholar9. Monafo WJ, Haslam DB, Roberts RL, Zaki SR, Bellini WJ, Coffin CM. Disseminated measles infection after vaccination in a child with a congenital immunodeficiency. J Pediatr. 1994; 124:273-6. Google Scholar10. McCrumb FR, Kress S, Saunders E, Snyder MJ, Schluederberg AE. Studies with live attenuated measles virus vaccine. Am J Dis Child. 1961; 101:45-56. Google Scholar11. Katz SL, Enders JF, Holloway A. Studies on an attenuated measles-virus vaccine. II. Clinical, virologic, and immunologic effects of vaccine in institutionalized children. N Engl J Med. 1960; 263:159-61. Google Scholar12. Frenkel LM, Nielsen K, Garakian A, Cherry JD. A search for persistent measles, mumps, and rubella vaccine virus in children with human immunodeficiency virus type 1 infection. Arch Pediatr Adolesc Med. 1994; 148:57-60. Google Scholar13. Kawashima H, Mori T, Takekuma K, Hoshika A, Hata M, Nakayama T. Polymerase chain reaction detection of hemagglutinin gene from an attenuated measles vaccine strain in the peripheral mononuclear cells of children with autoimmune hepatitis. Arch Virol. 1996; 141:877-94. Google Scholar14. Measles pneumonitis following measles-mumps-rubella vaccination of a patient with HIV infection, 1993. MMWR Morb Mortal Wkly Rep. 1996; 45:603-6. Google Scholar15. American Academy of Pediatrics. Measles. In: Peter G, ed. 1997 Red Book: Report of the Committee on Infectious Diseases. 24th ed. Elk Grove Village, IL: American Academy of Pediatrics; 1997:344-57. Google Scholar Author, Article, and Disclosure InformationAuthors: Jonathan B. Angel, MD; Pramila Walpita, PhD; Robert A. Lerch, PhD; Mohinderjit S. Sidhu, PhD; Malthi Masurekar, PhD; Ronald A. DeLellis, MD; James T. Noble, MD; David R. Syndman, MD; Stephen A. Udem, MD, PhDAffiliations: From Tufts University School of Medicine and New England Medical Center, Boston, Massachusetts; New Jersey Medical School, Newark, New Jersey; and Wyeth-Lederle Vaccines & Pediatrics, Pearl River, New York.Grant Support: In part by National Institutes of Health grants AI 20532, 2 SO7 RR05393, and AI 35286.Corresponding Author: Stephen A. Udem, MD, PhD, Wyeth-Lederle Vaccines & Pediatrics, 401 North Middletown Road, Pearl River, NY 10965.Current Author Addresses: Drs. Angel, Noble, DeLellis, and Syndman: Department of Medicine, Division of Geographic Medicine and Infectious Diseases, Tufts University School of Medicine, 750 Washington Street, Boston, MA 02111. 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