Arthritis after Bacillus Calmette-Guerin Therapy
Authors: David W. Puett, Howard A. Fuchs
Journal: Annals of Internal Medicine (1992)

Letters15 September 1992Arthritis after Bacillus Calmette-Guerin TherapyDavid W. Puett, MD, Howard A. Fuchs, MDDavid W. Puett, MDSearch for more papers by this author, Howard A. Fuchs, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-117-6-537_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors:A 49-year-old male had transurethral resection and intravesical and intramuscular bacillus Calmette-Guerin (BCG) therapy in 1988 for transitional cell carcinoma of the bladder. From October to December 1991, he again received intravesicular BCG for tumor recurrence. Within 2 weeks of the last instillation, he developed metatarsophalangeal joint and hip pain. Physical examination showed dactylitis of the left fourth toe, pain with motion of his right hip, and stress of both sacroiliac joints. Erythrocyte sedimentation rate was 61 mm/h, and rheumatoid factor was absent. Indomethacin, 50 mg three times a day, isoniazid, 300 mg/d, and rifampin, 600 mg/d,...References1. Orihuela E, Herr H, Pinsky C, and Whitmore W. Toxicity of intravesical BCG and its management in patients with superficial bladder tumors. Cancer. 1987;60:326-33. CrossrefMedlineGoogle Scholar2. Hughes R, Allard S, and Maini R. Arthritis associated with adjuvant mycobacterial treatment for carcinoma of the bladder. Ann Rheum Dis. 1989;48:432-4. CrossrefMedlineGoogle Scholar3. Ochsenkuhn T, Weber M, and Caselmann W. Arthritis after Mycobacterium bovis immunotherapy for bladder cancer. Ann Intern Med. 1990;112:882. LinkGoogle Scholar4. Hogervorst E, Boog C, Wagenaar J, Wauben M, van der Zee R, and van Eden W. T cell reactivity to an epitope of the mycobacterial 65 kDa heat-shock protein (hsp 65) corresponds with arthritis susceptibility in rats and is regulated by hsp 65-specific cellular responses. Eur J Immunol. 1991;21:1289-96. CrossrefMedlineGoogle Scholar5. Res P, Schaar C, Breed veld F, van Eden W, van Embden J, and Cohen I. Synovial fluid T cell reactivity against 65 kD heat shock protein of mycobacteria in early chronic arthritis. Lancet. 1988;2:478-80. CrossrefMedlineGoogle Scholar6. Jardetzky T, Lane W, Robinson R, Madden D, and Wiley D. Identification of self peptides bound to purified HLA-B27. Nature. 1991;353:321-5. CrossrefMedlineGoogle Scholar7. Bardwell J and Craig E. Eukaryotic Mr 83,000 heat shock protein has a homologue in Escherichia coli. Proc Natl Acad Sci USA. 1987;84:5177-81. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: David W. Puett, MD; Howard A. Fuchs, MDAffiliations: Vanderbilt University School of Medicine Nashville, TN 37232-2681 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAutoimmune disorders caused by intravesical bacillus Calmette-Guerine treatment: A systematic reviewUnusual evolution of reactive arthritis induced by BCG therapyBacillus Calmette-Guérin (BCG) Infection Following Intravesical BCG Administration as Adjunctive Therapy For Bladder CancerReactive arthritis induced by intravesical BCG therapy for bladder cancer: our clinical experience and systematic review of the literatureRheumatoid Arthritis, Vasculitis, and Mononeuritis Multiplex After BCG Used in a Patient With Bladder CarcinomaArthrites réactionnelles secondaires à la BCG-thérapie. Deux observations et revue de la littératurePan-uvéite dans les suites d’instillations intravésicales de BCG (Bacille de Calmette et Guérin)Osteoarticular side effects of BCG therapyComplications rhumatologiques de la BCG-thérapieEntzündungen bekannter ÄtiologieBronchectasies et polyarthrite rhumatoïde. Fréquence et aspects étiopathogéniques. Revue de la littératureSpondiloartrite Acuta: Rara Complicanza in Corso di Terapia Endovescicale con BCGImmunomodulating agentsBCG 15 September 1992Volume 117, Issue 6Page: 537-537KeywordsArthralgiaArthritisBacille calmette guerinBacillusBladderErythrocyte sedimentation rateHipIsoniazid ePublished: 1 December 2008 Issue Published: 15 September 1992 PDF downloadLoading ...