tbuckley/cabot-search huggingface dataset:
Videometric analysis of regional left ventricular function before and after aortocoronary artery bypass surgery: correlation of peak rate of myocardial wall thickening with late postoperative graft flows.
Authors: J H Chesebro, E L Ritman, R L Frye, H C Smith, D C Connolly, B D Rutherford, G D Davis, G K Danielson, J R Pluth, D A Barnhorst, R B Wallace
Journal: Journal of Clinical Investigation (1976)

The peak rate of systolic wall thickening (pdTw/dt) in regions of the left ventricle was determined by biplane roentgen videometry in 60 patients before and a median of 14 mo after aorto-coronary bypass graft surgery. The left ventricular ejection fraction, stroke volume, and end-diastolic volume and pressure did not change significantly after surgery in the presence of patent or occluded grafts (P greater than 0.05). Statistically significant increases occurred in the peak rate of systolic wall thickening regions supplied by patent bypass grafts, and significant decreases occurred in regions with occluded grafts (P less than 0.01). Of 42 preoperatively hypokinetic regions (pdTw/dt greater than 0 less than 5.0 cm/s) supplied by a patent graft, 30 improved by an average of 2.6 cm/s after operation; 18 returned to normal. Failure of 24 hypokinetic regions to improve to normal was associated with myocardial infarction in 11 or with late postoperative graft blood flows of less than 60 ml/min measured by videodensitometry, in 10. All seven preoperatively akinetic (pdTw/dt=0) or dyskinetic (pdTw/dt less than 0) regions did not improve after the operation despite the fact that, in five of the seven, coronary bypass flows were over 60 ml/min. All eight preoperatively hypokinetic regions supplied by coronary artery graft flows of less than or equal 40 ml/min failed to improve to normal after operation. All nine preoperatively hypokinetic regions supplied by coronary artery graft flows of over 60 ml/min improved to normal after surgery. Late postoperative coronary artery bypass graft flows, the functional status of the myocardium, the status and distribution of the native coronary circulation, and decreased regional function elsewhere in the ventricle must all be considered when regional left ventricular function is interpreted.
New Hampshire Medical Society
Authors: Robert O. Blood, Benjamin P. Burpee, James Sanders
Journal: New England Journal of Medicine (1948)

The report of the Committee on National Emergency Medical Service was then presented:At the spring meeting of the American Medical Association Council on National Emergency Medical Service, held at Chicago April 5 and 6, the New Hampshire Medical Society was represented by the chairman of the Committee. At that session various speakers from different branches of the government and various civilian organization officials were heard, and outlined the kind of national emergency that might exist in case of another war. The meaning of atomic warfare was expounded, and certain proposals were made, with the purpose of arriving at a . . .
Anesthesia Technique, Mortality, and Length of Stay After Hip Fracture Surgery
Authors: Mark D. Neuman, Paul R. Rosenbaum, Justin M. Ludwig, Jose R. Zubizarreta, Jeffrey H. Silber
Journal: JAMA (2014)

More than 300,000 hip fractures occur each year in the United States. Recent practice guidelines have advocated greater use of regional anesthesia for hip fracture surgery.To test the association of regional (ie, spinal or epidural) anesthesia vs general anesthesia with 30-day mortality and hospital length of stay after hip fracture.We conducted a matched retrospective cohort study involving patients 50 years or older who were undergoing surgery for hip fracture at general acute care hospitals in New York State between July 1, 2004, and December 31, 2011. Our main analysis was a near-far instrumental variable match that paired patients who lived at different distances from hospitals that specialized in regional or general anesthesia. Supplementary analyses included a within-hospital match that paired patients within the same hospital and an across-hospital match that paired patients at different hospitals.Spinal or epidural anesthesia; general anesthesia.Thirty-day mortality and hospital length of stay. Because the distribution of length of stay had long tails, we characterized this outcome using the Huber M estimate with Huber weights, a robust estimator similar to a trimmed mean.Of 56,729 patients, 15,904 (28%) received regional anesthesia and 40,825 (72%) received general anesthesia. Overall, 3032 patients (5.3%) died. The M estimate of the length of stay was 6.2 days (95% CI, 6.2 to 6.2). The near-far matched analysis showed no significant difference in 30-day mortality by anesthesia type among the 21,514 patients included in this match: 583 of 10,757 matched patients (5.4%) who lived near a regional anesthesia-specialized hospital died vs 629 of 10,757 matched patients (5.8%) who lived near a general anesthesia-specialized hospital (instrumental variable estimate of risk difference, -1.1%; 95% CI, -2.8 to 0.5; P = .20). Supplementary analyses of within and across hospital patient matches yielded mortality findings to be similar to the main analysis. In the near-far match, regional anesthesia was associated with a 0.6-day shorter length of stay than general anesthesia (95% CI, -0.8 to -0.4, P < .001). Supplementary analyses also showed regional anesthesia to be associated with shorter length of stay, although the observed association was smaller in magnitude than in the main analysis.Among adults in acute care hospitals in New York State undergoing hip repair, the use of regional anesthesia compared with general anesthesia was not associated with lower 30-day mortality but was associated with a modestly shorter length of stay. These findings do not support a mortality benefit for regional anesthesia in this setting.
P08.17 * REPEAT STEREOTACTIC RADIOSURGERY (SRS) FOR RECURRENT BRAIN METASTASES
Authors: G. Minniti, E. Clarke, C. Scaringi, T. Falco, M. Osti, R. M. Enrici
Journal: Neuro-Oncology (2014)

OBJECTIVES: SRS for brain metastases is an effective treatment for brain metastases with a reported survival of 7-14 months. Local control is in the range of 70-90% at 12 months, with a proportion of patients who recurs locally we have evaluate the efficacy of repeat stereotactic radiosurgery (SRS) as salvage treatment in patients with recurrent brain metastases. PATIENTS AND METHODS: Between May 2008 and December 2012, twenty-seven patients received repeat SRS for a recurrent brain metastasis at University of Rome Sapienza, Sant'Andrea Hospital. All patients had Karnofsky Performance Score ≥ 60 and were previously treated with single-fraction SRS. The median time interval between primary SRS and reirradiation was 13.5 months. At the time of recurrence all patients received multi-fraction SRS (7-8 Gy x 3) RESULTS: Median overall and 12-month survival rates after repeat multifraction SRS were 10.3 months and 37%, respectively. Six patients were alive at the of analysis. The 6-month and 12-month local control rates were 90% and 72%. KPS > 70 (p = 0.04) and presence of extracranial disease (p = 0.01) were significant prognostic factor associated with longer survival. In general the treatment was well tolerated with relatively low treatment-related toxicity. Radionecrosis occurred in 7 reirradiated lesions, and was associated with neurological deterioration in 3 of them. CONCLUSION: Multi-fraction SRS is a feasible treatment option associated with good local control and acceptable radiation-induced toxicity in selected patients with recurrent brain metastases.
High-dose glucocorticosteroids increase the procoagulant effects of OKT3
Authors: Daniel Abramowicz, Olivier Pradier, Luc. De Pauw, Paul Kinnaert, Olivier Mat, Muriel Surquin, Jean-Marc Doutrelepont, Jean-Louis Vanherweghem, Paul Capel, Pierre Vereerstraeten, Michel Goldman
Journal: Kidney International (1994)
What Is the Histone Code, and Why Is It Important?
Authors: S. Oesterreich
Journal: Cancer Research (2009)

Abstract The field of epigenetics is rapidly expanding, and has changed and revised traditional paradigms of inheritance. Epigenetics, literally “beyond genetics” or “in addition to genetics”, is defined as the study of heritable changes in gene expression that occur without a change in DNA sequence. Within this presentation, I will focus on modifications of histones, an important mechanism to convey epigenetic information. Histones, small proteins which serve as spools for DNA wrapped in nucleosomes, are critical regulators of the dynamic state of chromatin. They are subject to numerous posttranslational modifications, including acetylation, methylation, ubiquitylation, and phosphorylation. The best characterized modifications are acetylations and methylations. Increased acetylation of histones by histone acetyltransferases is associated with gene activation due to weakened charge attraction between DNA and histone; histone deacetylases in contrast remove acetyl groups leading to gene inactivation. Histone methylation mediated by histone methyltransferases has either positive effects or negative effects on gene expression depending on location and association of other protein complexes. In general, it is difficult to predict gene regulation based on the study of a single histone modification, since it is the combination of these modifications, also called the histone code, which ultimately controls gene expression. I will discuss details of the histone modification, how they regulate gene expression, and also their relevance in disease, especially breast cancer. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr ES4-2.
Serological profiles in the connective tissue diseases in Zimbabwean patients.
Authors: P Davis, M Stein, H Ley, C Johnston
Journal: Annals of the Rheumatic Diseases (1989)

The serological profiles of 104 Zimbabwean patients with clinically diagnosed connective tissue diseases were determined. The prevalence of rheumatoid factor was less than would have been expected in other geographical groups, but the prevalence of antinuclear antibodies was similar. Despite considerable racial, socioeconomic, and genetic differences in our patient group compared with other previously published studies the specificity and sensitivity of antinuclear antibodies, notably to DNA and Sm, correlated well with clinical diagnoses. This study validates the use of these serological tests in the investigation of this group of patients.
Ovarian Avatar Models Predictive of Platinum Response in Ovarian Cancer Patients
Authors: S.J. Weroha, P. Haluska, M.A. Becker, S.C. Harrington, K.M. Goodman, S.E. Gonzalez, M. al Hilli, K.A. Butler, K.R. Kalli, A.L. Oberg
Journal: Annals of Oncology (2013)
Green Paper and the Teaching Hospitals
Authors: P. Newman
Journal: BMJ (1970)

refers I did not comment directly on the case for or against a large increase in number, but was concerned with the evi- dence indicating that the Royal Commission had failed to understand the mathematical basis on which they proposed an exponential expansion, and had thus reached a wholly unjustifiable conclusion about the number of doctors necessary.I also drew attention to the implications of an error of this magnitude, which could require perhaps the provision of 10,000 unnecessary doctors in 10 years, a number equivalent to the output of five new medical schools.As this appears a serious matter, one would expect the mathematical errors in this section of the report to have been ac- knowledged and corrected before now, since it must surely be necessary to prepare a new estimate based on less indefensible grounds.If, however, my conclusions are unjustified, it should be an easy matter to refute them.-Iam, etc.,
Abstract 5532: Anti-cancer activities of tea epigallocatechin-3-gallate in breast cancer patients under radiotherapy
Authors: Erxi Wu
Journal: Cancer Research (2012)

Abstract Abstract: The purpose of this study was to test the hypothesis that administration of epigallocatechin-3-gallate (EGCG), a polyphenol present in abundance in widely consumed tea, inhibits cell proliferation, invasion, and angiogenesis in breast cancer patients. EGCG in 400 mg capsules was orally administered three times daily to breast cancer patients undergoing treatment by radiotherapy. Parameters related to cell proliferation, invasion, and angiogenesis were analyzed while blood samples were collected at different time points to determine efficacy of the EGCG treatment. Compared to patients who received radiotherapy alone, those given radiotherapy plus EGCG for an extended time period (two to eight weeks) showed significantly lower serum levels of vascular endothelial growth factor (VEGF), hepatocyte growth factor (HGF), and reduced activation of metalloproteinase-9 and metalloproteinase-2 (MMP9/MMP2). Addition of sera obtained from patients treated by combination of radiotherapy and EGCG feeding for 2-8 weeks to in vitro cultures of highly-metastatic human MDA-MB-231 breast cancer cells resulted in the following significant changes: (1) suppression of cell proliferation and invasion; (2) arrest of cell cycles at the G0/G1 phase; (3) reduction of activation of MMP9/MMP2, expressions of Bcl-2/Bax, c-Met receptor, NF-κB, and the phosphorylation of Akt. MDA-MB-231 cells exposed to 5-10 µM EGCG also showed significant augmentation of the apoptosis inducing effects of γ-radiation, concomitant with reduced NF-κB protein level and AKT phosphorylation. These results provide hitherto unreported evidence that EGCG potentiated efficacy of radiotherapy in breast cancer patients, and raise the possibility that this tea polyphenol has potential to be a therapeutic adjuvant against human metastatic breast cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5532. doi:1538-7445.AM2012-5532
Potential Overdiagnosis of Basal Cell Carcinoma in Older Patients With Limited Life Expectancy
Authors: Eleni Linos, Steven A. Schroeder, Mary-Margaret Chren
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HIF1α and HIF2α independently activate SRC to promote melanoma metastases
Authors: Sara C. Hanna, Bhavani Krishnan, Sean T. Bailey, Stergios J. Moschos, Pei-Fen Kuan, Takeshi Shimamura, Lukas D. Osborne, Marni B. Siegel, Lyn M. Duncan, E. Tim O’Brien, Richard Superfine, C. Ryan Miller, M. Celeste Simon, Kwok-Kin Wong, William Y. Kim
Journal: Journal of Clinical Investigation (2013)

Malignant melanoma is characterized by a propensity for early lymphatic and hematogenous spread. The hypoxia-inducible factor (HIF) family of transcription factors is upregulated in melanoma by key oncogenic drivers. HIFs promote the activation of genes involved in cancer initiation, progression, and metastases. Hypoxia has been shown to enhance the invasiveness and metastatic potential of tumor cells by regulating the genes involved in the breakdown of the ECM as well as genes that control motility and adhesion of tumor cells. Using a Pten-deficient, Braf-mutant genetically engineered mouse model of melanoma, we demonstrated that inactivation of HIF1α or HIF2α abrogates metastasis without affecting primary tumor formation. HIF1α and HIF2α drive melanoma invasion and invadopodia formation through PDGFRα and focal adhesion kinase-mediated (FAK-mediated) activation of SRC and by coordinating ECM degradation via MT1-MMP and MMP2 expression. These results establish the importance of HIFs in melanoma progression and demonstrate that HIF1α and HIF2α activate independent transcriptional programs that promote metastasis by coordinately regulating cell invasion and ECM remodeling.
Control of Plasma Nitric Oxide Bioactivity by Perfluorocarbons
Authors: Olga Rafikova, Elena Sokolova, Ruslan Rafikov, Evgeny Nudler
Journal: Circulation (2004)

Perfluorocarbons (PFCs) are promising blood substitutes because of their chemical inertness and unparalleled ability to transport and upload O2 and CO2. Here, we report that PFC emulsions also efficiently absorb and transport nitric oxide (NO).Accumulation of NO and O2 in PFC micelles results in rapid NO oxidation and generation of reactive NO(x) species. Such micellar catalysis of NO oxidation leads to formation of vasoactive S-nitrosothiols (RSNO) in vitro and in vivo as detected electrochemically. The efficiency of PFC-mediated S-nitrosation depends on the amount of PFC in aqueous solution. The optimal PFC concentration that produced the maximum level of RSNO was approximately 1% (vol/vol). Larger PFC amounts were progressively less efficient in generating RSNO and functioned simply as NO sink. These results explain the characteristic hemodynamic effects of PFCs. Intravenous bolus application of PFC (0.14 g/kg, approximately 1% vol/vol) to Wistar-Kyoto rats decreased mean arterial pressure significantly (-10 mm Hg over 40 minutes). PFC-induced hypotension could be further stimulated (-17 mm Hg over 140 minutes) by exogenous thiols (cysteine and glutathione). In contrast, a larger amount of PFC (1 g/kg, approximately 7% vol/vol) exhibited a strong hypertensive effect (11 mm Hg over 40 minutes).The present study reveals a physiologically significant pool of endogenous plasma NO and underscores the crucial role of the circulating hydrophobic phase in modulating its bioactivity. The results also establish PFC as a conceptually new pharmacological tool for various cardiovascular complications associated with NO imbalance.
Nifedipine and a Diabetic Ulcer
Authors: ROBERT J. LAZARUS
Journal: Annals of Internal Medicine (1983)

Letters and Corrections1 March 1983Nifedipine and a Diabetic UlcerROBERT J. LAZARUS, M.D., ALTUG ONOR, M.D., KHAN HAMEED, M.D.ROBERT J. LAZARUS, M.D.Search for more papers by this author, ALTUG ONOR, M.D.Search for more papers by this author, KHAN HAMEED, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-98-3-414_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Nifedipine has been used with good results in the treatment of the refractory digital ulcers associated with Raynaud's phenomenon (1-3). We used nifedipine in the treatment of an ulcer on the foot of a patient with diabetes.A 83-year-old woman with a 30-year history of non-insulin-dependent diabetes mellitus was hospitalized because of an ulcer on the dorsum of her right foot. Despite hydrotherapy and application of povidone-iodine dressings daily, and occasional debridement, the ulcer progressed until the extensor tendons of her toes were exposed. We noted, on the 24th hospital day, that amputation would probably be needed....References1. KAHAN A, WEBER S, AMOR B, SAPORTA L, HODARA M, and DESGEORGES M. Nifedipine and Raynaud's phenomenon [Letter]. Ann Intern Med. 1981;94:546. LinkGoogle Scholar2. VAYSSAIRAT M, CAPRON L, FIESSINGER J, MATHIEU J, and HOUSSET E. Calcium channel blockers and Raynaud's disease [Letter]. Ann Intern Med. 1981;95:243. LinkGoogle Scholar3. JAFFE I. Nifedipine in digital ulceration in scleroderma [Letter]. Arthritis Rheum. 1982;25:1267-9. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROBERT J. LAZARUS, M.D.; ALTUG ONOR, M.D.; KHAN HAMEED, M.D.Affiliations: Downstate Medical Center and College of Medicine State University of New York Brooklyn, NY 11203 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIndications for Calcium AntagonistsIndikationen für Calcium-Antagonisten 1 March 1983Volume 98, Issue 3Page: 414-414KeywordsRaynaud syndromeTendonsType 2 diabetesUlcers ePublished: 1 December 2008 Issue Published: 1 March 1983 PDF downloadLoading ...
1124 2250MG/DAY OF TELAPREVIR DOSAGE IMPAIR THE RIBAVIRIN DOSAGE AND CLINICAL EFFECT OF TRIPLE THERAPY IN THE PATIENTS WITH A LOW TOTAL CLEARANCE OF RIBAVIRIN
Authors: Y. Karino, T. Nakajima, I. Ozeki, J. Toyota, M. Imamura, M. Tsuge, K. Chayama, N. Akuta, F. Suzuki, H. Kumada
Journal: Journal of Hepatology (2012)
Three further cases of t(8;14)(q11.2;q32) in acute lymphoblastic leukemia
Authors: S-A Byatt, K-L Cheung, DM Lillington, H Mazzullo, M Martineau, C Bennett, K Roberts, L Harewood, N Sumption, M Humphreys, J Burrett, CJ Harrison
Journal: Leukemia (2001)
Tolerance, Effectiveness, and Acceptability of Sulfate-Free Electrolyte Lavage Solution for Colon Cleansing Before Colonoscopy
Authors: J.-M. Raymond, R. Beyssac, E. Capdenat, C.-H. Pineau, A. Kerjean, M.-C. Saux, P. Couzigou, M. Amouretti
Journal: Endoscopy (1996)

Background and Study Aims: The unpleasant taste of the solution used for preparation before colonoscopy may limit patients' compliance with the procedure. However, the published results concerning the acceptability of sulfate-free electrolyte lavage solution (SF-ELS) for colon cleansing before colonoscopy are conflicting. The aim of this study was to compare SF-ELS with the standard polyethylene glycol (PEG) solution with regard to tolerance, effectiveness, and acceptability.
Distribution of Atrial Septal Defect Types in Young Turkish Popülation and Percutaneous Closure of Secundum Atrial Septal Defects; 163 Cases
Authors: Hasan Arı, Nadir Emlek, Serdar Keçeoğlu, İbrahim Aktaş, Ahmet Tütüncü, Gökhan Özmen, Kubra Doğanay, Selvi Coşar, Tufan Günay, Mehmet Demir, Mehmet Melek, Tahsin Bozat, Vedat Koca
Journal: Journal of the American College of Cardiology (2013)
Bethanidine in hypertension.
Authors: A. W. Leishman, J. L. Thirkettle, B. R. Allen
Journal: BMJ (1968)

BmJoum "depression" is as precise as the diagnosis and therapy of " anaemia " without further analysis.'I recently listened to a lecture for general practitioners on depression by a consultant psychiatrist, in which nearly every psychiatric complaint or condition other than schizo- phrenia, mania, and sociopathy was accused of being "depression."Does anyone else share my misgivings about the near-total victory of " depression " over psychiatry ?I am, etc.,