tbuckley/cabot-search huggingface dataset:
Autologous stem cell transplantation with<i>in vivo</i>purged progenitor cells shows long-term efficacy in relapsed/refractory follicular lymphoma
Authors: Luca Arcaini, Lucia Morello, Alessandra Tucci, Chiara Rusconi, Marco Ladetto, Sara Rattotti, Maurizio Bonfichi, Chiara Bottelli, Cristina Gabutti, Paolo Bernasconi, Marzia Varettoni, Manuel Gotti, Daniela Troletti, Maria Luisa Guerrera, Valeria Fiaccadori, Roberta Sciarra, Virginia Valeria Ferretti, Emilio Paolo Alessandrino, Giuseppe Rossi, Enrica Morra
Journal: American Journal of Hematology (2014)

High-dose chemotherapy with autologous stem cell transplantation (ASCT) has been shown effective in the control of relapsed/refractory follicular lymphoma. We evaluate the long-term outcome of patients with relapsed or refractory follicular lymphoma treated with ASCT with in vivo purged progenitors cells. We report the long-term results of a prospective multicenter phase 2 trial on 124 relapsed/refractory follicular lymphoma patients treated with a program of anthracycline-based debulking chemotherapy, immunochemotherapy, mobilization of in vivo purged PBSC followed by ASCT. Median age was 52 years; 14% of patients had grade 3A histology. Debulking chemotherapy produced CR in 16% and PR in 71%, while 13% of patients progressed. After rituximab, cyclophosphamide, vincristine, prednisone (R-COP), CR was obtained in 60% and PR in 35%; 118 patients successfully mobilized PBSC and 117 proceeded to ASCT. The harvest in all the 32 molecularly informative patients was bcl-2 negative. TRM was 0%. The 5-year PFS was 54% and the 5-year OS was 83%. After a median f-up of 6.7 years (range 1.5-13.6), 54% are still in CR. These data show that prolonged PFS is achievable in relapsed/refractory patients with high dose autologous transplantation of in vivo purged progenitor cells.
Sexual contact in the doctor-patient relationship in The Netherlands.
Authors: D. Wilbers, G. Veenstra, H. B. van de Wiel, W. C. Weijmar Schultz
Journal: BMJ (1992)

To obtain data on sexual contact between doctors and their patients.Anonymous questionnaire with 17 items sent to all working gynaecologists (n = 595) and all ear, nose, and throat specialists (n = 380) in the Netherlands.Response rate was 74%; a total 64 doctors gave a reason for not completing the questionnaire. 201 (59%) male gynaecologists and 128 (56%) male ear nose, and throat specialists indicated that sexual feelings are acceptable in the doctor-patient relationship; 286 (85%) and 186 (81%), respectively, had felt sexually attracted to a patient at some time, as had 14 (27%) female gynaecologists. More than half (59%) of the doctors who indicated that sexual feelings are unacceptable in the doctor-patient relationship had experienced these feelings, and 91% of this group had a negative attitude towards these feelings. 4% of respondents in each group had had actual sexual contact with patients. Most gynaecologists were in favour of having more attention paid to sexual problems during training; having their professional society take an official viewpoint; subsequent public support of this viewpoint; and taking on an impartial counsellor for the patients as well as the doctors.Sexuality exists in the doctor-patient relationship. Gynaecologists have a higher risk of having sexual contact with their patients than do ear, nose, and throat specialists but compensate for this greater risk by a higher state of recognition and acknowledgement.
Operation for repair of obstructed substernocostal (Morgagni) hernia
Authors: K Moghissi
Journal: Thorax (1981)

A complicated case of large substernocostal hernia in a 67-year-old man is described. A new surgical approach via upper laparotomy which can be extended by a lower median sternotomy, allowing complete access to the hernia was tried successfully and the patient9s recovery was uneventful.
Utility of ultrasound joint counts in the prediction of rheumatoid arthritis in patients with very early synovitis
Authors: Andrew Filer, Paola de Pablo, Gina Allen, Peter Nightingale, Alison Jordan, Paresh Jobanputra, Simon Bowman, Christopher D Buckley, Karim Raza
Journal: Annals of the Rheumatic Diseases (2010)

Objectives Early therapy improves outcomes in rheumatoid arthritis (RA). It is therefore important to improve predictive algorithms for RA in early disease. This study evaluated musculoskeletal ultrasound, a sensitive tool for the detection of synovitis and erosions, as a predictor of outcome in very early synovitis. Methods 58 patients with clinically apparent synovitis of at least one joint and symptom duration of ≤3 months underwent clinical, laboratory, radiographic and 38 joint ultrasound assessments and were followed prospectively for 18 months, determining outcome by 1987 American College of Rheumatology (ACR) and 2010 ACR/European League Against Rheumatism criteria. Sensitivity and specificity for 1987 RA criteria were determined for ultrasound variables and logistic regression models were then fitted to evaluate predictive ability over and above the Leiden rule. Results 16 patients resolved, 13 developed non-RA persistent disease and 29 developed RA by 1987 criteria. Ultrasound demonstrated subclinical wrist, elbow, knee, ankle and metatarsophalangeal joint involvement in patients developing RA. Large joint and proximal interphalangeal joint ultrasound variables had poor predictive ability, whereas ultrasound erosions lacked specificity. Regression analysis demonstrated that greyscale wrist and metacarpophalangeal joint involvement, and power Doppler involvement of metatarsophalangeal joints provided independently predictive data. Global ultrasound counts were inferior to minimal power Doppler counts, which significantly improved area under the curve values from 0.905 to 0.962 combined with the Leiden rule. Conclusion In a longitudinal study, extended ultrasound joint evaluation significantly increased detection of joint involvement in all regions and outcome groups. Greyscale and power Doppler scanning of metacarpophalangeal joints, wrists and metatarsophalangeal joints provides the optimum minimal ultrasound data to improve on clinical predictive models for RA.
Is the lifetime of light-stimulated cGMP phosphodiesterase regulated by recoverin through its regulation of rhodopsin phosphorylation?
Authors: Akio Yamazaki
Journal: Behavioral and Brain Sciences (1995)

Abstract In the current model of visual transduction, the lifetime of active cGMP phosphodiesterase depends upon the period of its interaction with GTP-bound transducin. If recoverin regulates the lifetime of light-activated cGMP phosphodiesterase through inhibition of rhodopsin phosphorylation, rhodopsin should directly interact with cGMP phosphodiesterase and/or GTP-bound transducin complexed with cGMP phosphodiesterase. Is this true?
Association of certain Ia allotypes with the occurrence of chronic lymphocytic leukemia. Recognition by a monoclonal anti-Ia reagent of a susceptibility determinant not in the DR series
Authors: A Nunez-Roldan, I Szer, T Toguchi, J Cuttner, R Winchester
Journal: The Journal of Experimental Medicine (1982)

The Ia antigen allospecificities of individuals with B type chronic lymphocytic leukemia differed significantly from those of a control population. A monoclonal antibody, IVD12, directed to a MB3-1ike determinant, reacted with 92.5 percent of the individuals with leukemia and yielded the greatest positive relative risk, 13.5. A lower degree of positive association was found with the presence of the MT2 determinant. In contrast, the low observed frequency of the MT1/MB1 determinant among leukemic individuals was associated with the most significant negative relative risk, -8.1. Among HLA- DR specificities, the relative risk associated with the presence of DR5 was positive while that with DR2 was negative.
COPD patients' ability to follow exercise influences short-term outcomes of rehabilitation
Authors: M. A. Puhan, H. J. Schünemann, G. Buesching, E. vanOort, A. Spaar, M. Frey
Journal: European Respiratory Journal (2007)

Chronic obstructive pulmonary disease (COPD) patients with limited ability to follow exercise protocols may receive smaller benefits from rehabilitation. The association between the ability to follow exercise protocols and short-term outcomes of rehabilitation was assessed in COPD patients. As a measure of the ability to follow exercise protocols, the number of major breaks lasting ≥1 min was determined in 98 COPD patients during supervised exercise sessions. The benefits from rehabilitation were compared between patients with, on average, more than one and one or fewer major breaks per session. Patients with one or fewer major breaks per session showed significantly greater improvements in exercise capacity (between-groups difference of 38 m for 6-min walking distance, 22.1 W for short-time maximum exercise capacity (steep ramp test) and 5.5 W for maximum exercise capacity). Quality of life also tended to be better in patients with one or fewer major breaks per session, but the differences were nonsignificant (adjusted between-groups difference in Chronic Respiratory Disease Questionnaire total score of 0.14). Limited ability to follow exercise protocols is associated with smaller benefits of rehabilitation. This finding highlights the importance of choosing tolerable exercise protocols for chronic obstructive pulmonary disease patients.
The Water and Electrolyte Content of the Tissues in Hypertension
Authors: ARTHUR GROLLMAN, CHARLES CAMPBELL, JOB MlMS, FLOYD RECTOR
Journal: Circulation Research (1954)

An analysis of the water and electrolyte content of various tissues of rats rendered hypertensive by a period of choline deficiency at the time of weaning indicates that no alterations are induced by this procedure. It is concluded that the hypertensive process, per se, is not necessarily accompanied by changes in the water and electrolyte content of tissues; where such changes are observed, they are probably secondary to parenchymal renal changes.
Visual Phenomenology in Recently Blind Adults
Authors: ROY G. FITZGERALD
Journal: American Journal of Psychiatry (1971)

A psychosocial investigation of 66 recently blind adults revealed that depressive reactions were prominent in a generally abating course. Visual residua and behaviors irrelevant to blindness occurred in all subjects. They are described and related to maladaptive coping as follows: visual experiences waking and sleeping (85 percent of the sample); recurrent affective responses to dreaming and waking events, and visual residua in cognitive and motor behavior (100 percent); and maalaptive coping and diminished awareness of blindness (95 percent).
Evaluation of positive expiratory pressure as an adjunct to chest physiotherapy in the treatment of cystic fibrosis.
Authors: J L Hofmeyr, B A Webber, M E Hodson
Journal: Thorax (1986)

It has been suggested that positive expiratory pressure may assist the clearance of bronchial secretions in the treatment of cystic fibrosis. It has been compared with currently used postural drainage techniques. Three treatment regimens were compared in 18 patients with cystic fibrosis. Treatment A consisted of breathing exercises emphasising inspiration, interspersed with the forced expiration technique in gravity assisted positions; treatment B comprised breathing exercises with positive expiratory pressure alternating with the forced expiration technique in the same gravity assisted positions; and treatment C comprised breathing exercises with positive expiratory pressure and the forced expiration technique in the sitting position. During treatment A a significantly greater quantity of sputum was produced than during treatments B and C (p less than 0.025 and p less than 0.001 respectively). Treatment B produced more sputum than treatment C (p less than 0.005). There were no significant differences in arterial oxygen saturation, FEV1 or forced vital capacity. Most adolescent and adult patients are able to carry out their treatment independently using gravity assisted positions, breathing exercises emphasising inspiration, and the forced expiration technique. Sputum clearance was less effective when positive expiratory pressure was included in the treatment regimen.
Interventions to Promote Repeat Breast Cancer Screening With Mammography: A Systematic Review and Meta-Analysis
Authors: Sally W. Vernon, Amy McQueen, Jasmin A. Tiro, Deborah J. del Junco
Journal: JNCI Journal of the National Cancer Institute (2010)

Various interventions to promote repeat use of mammography have been evaluated, but the efficacy of such interventions is not well understood.We searched electronic databases through August 15, 2009, and extracted data to calculate unadjusted effect estimates (odds ratios [ORs] and 95% confidence intervals [CIs]). Eligible studies were those that reported estimates of repeat screening for intervention and control groups. We tested homogeneity and computed summary odds ratios. To explore possible causes of heterogeneity, we performed stratified analyses, examined meta-regression models for 15 a priori explanatory variables, and conducted influence analyses. We used funnel plots and asymmetry tests to assess publication bias. Statistical tests were two-sided.The 25 eligible studies (27 effect estimates) were statistically significantly heterogeneous (Q = 69.5, I(2) = 63%, P < .001). Although there were homogeneous subgroups in some categories of the 15 explanatory variables, heterogeneity persisted after stratification. For all but one explanatory variable, subgroup summary odds ratios were similar with overlapping confidence intervals. The summary odds ratio for the eight heterogeneous reminder-only studies was the largest observed (OR = 1.79, 95% CI = 1.41 to 2.29) and was statistically significantly greater than the summary odds ratio (P(diff) = .008) for the homogeneous group of 17 studies that used the more intensive strategies of education/motivation or counseling (OR = 1.27, 95% CI = 1.17 to 1.37). However, reminder-only studies remained statistically significantly heterogeneous, whereas the studies classified as education/motivation or counseling were homogeneous. Similarly, in meta-regression modeling, the only statistically significant predictor of the intervention effect size was intervention strategy (reminder-only vs the other two combined as the referent). Publication bias was not apparent.The observed heterogeneity precludes a summary effect estimate. We also cannot conclude that reminder-only intervention strategies are more effective than alternate strategies. Additional studies are needed to identify methods or strategies that could increase repeat mammography.
Clinical features of De Novo acute myeloid leukemia with concurrent DNMT3A, FLT3 and NPM1 mutations
Authors: Sanam Loghavi, Zhuang Zuo, Farhad Ravandi, Hagop M Kantarjian, Carlos Bueso-Ramos, Liping Zhang, Rajesh R Singh, Keyur P Patel, L Jeffrey Medeiros, Francesco Stingo, Mark Routbort, Jorge Cortes, Rajyalakshmi Luthra, Joseph D Khoury
Journal: Journal of Hematology & Oncology (2014)

De novo acute myeloid leukemia (AML) with concurrent DNMT3A, FLT3 and NPM1 mutations (AML DNMT3A/FLT3/NPM1 ) has been suggested to represent a unique AML subset on the basis of integrative genomic analysis, but the clinical features of such patients have not been characterized systematically.We assessed the features of patients (n = 178) harboring mutations in DNMT3A, FLT3 and/or NPM1, including an index group of AML DNMT3A/FLT3/NPM1 patients.Patients with AML DNMT3A/FLT3/NPM1 (n = 35) were significantly younger (median, 56.0 vs. 62.0 years; p = 0.025), mostly women (65.7% vs. 46.9%; p = 0.045), and presented with a higher percentage of bone marrow blasts (p < 0.001) and normal cytogenetics (p = 0.024) in comparison to patients within other mutation groups in this study. Among patients <60 years old, those with AML DNMT3A/FLT3/NPM1 had a shorter event-free survival (EFS) (p = 0.047). DNMT3A mutations and not FLT3 or NPM1 mutations were independently associated with overall survival (OS) (p = 0.026). Within mutation subgroups, patients with AML DNMT3A/NPM1 had a significantly shorter OS compared to those with AML FLT3-ITD/NPM1 (p = 0.047) suggesting that the adverse impact of DNMT3A mutations is more pronounced than that of FLT3-ITD among patients with NPM1 mutation.DNMT3A has a significant dominant effect on the clinical features and outcomes of de novo AML patients with concurrent DNMT3A, FLT3 and NPM1 mutations.
Sympathetic Hyperactivity in Chronic Renal Failure
Authors: Hein A. Koomans, Peter J. Blankestijn, Jaap A. Joles
Journal: Journal of the American Society of Nephrology (2004)

ABSTRACT. Sympathetic hyperactivity plays an important and distinct role in hypertension associated with chronic renal failure (CRF). Renal ischemia, elevated angiotensin II, and suppressed brain nitric oxide (NO) all stimulate sympathetic activity. Evidence is accumulating for a role of sympathetic hyperactivity in renal and cardiac damage in patients with CRF. Decreased NO availability and increased oxidative stress, characteristic in CRF patients, seem to sensitize target organs for damaging actions of sympathetic hyperactivity. Fortunately, sympatholytic agents can slow down progression of renal and cardiac dysfunction. Angiotensin-converting enzyme inhibitors or angiotensin II receptor antagonists suppress sympathetic activity, but complete elimination of the effect of sympathetic hyperactivity can be obtained only with specific adrenergic blockers. However, this important therapeutic option is grossly neglected, painfully illustrated by the unwillingness to treat CRF patients with β-blockers, even if they have had a myocardial infarction. After discussion of mechanisms and effects of the sympathetic hyperactivity, a case is made for increased application of specific adrenergic blockers in patients with CRF.
Failure of sputum eosinophilia after eotaxin inhalation in asthma
Authors: D Bumbacea
Journal: Thorax (2004)

Eotaxin is a chemokine specific for eosinophils and may play an important role in eosinophil recruitment in asthma. The effects of eotaxin inhalation on sputum and blood eosinophils, exhaled nitric oxide (NO), and bronchial responsiveness were determined.Eotaxin was administered by nebulisation to asthma patients in three studies: (1) an open dose finding study with eotaxin (5, 10 and 20 microg) to two asthmatic subjects; (2) a randomised placebo controlled study with 20 microg eotaxin to five asthmatic subjects and five normal volunteers; and (3) a randomised placebo controlled study with 40 microg eotaxin to nine asthmatics. Forced expiratory volume in 1 second (FEV(1)), exhaled NO, and blood eosinophils were measured before and hourly for 5 hours after nebulisation and at 24 and 72 hours. Methacholine bronchial challenge and sputum induction were performed before and at 5, 24, and 72 hours after nebulisation.In the two placebo controlled studies there was no change in sputum eosinophil count and sputum eosinophilic cationic protein concentration after eotaxin inhalation compared with placebo. FEV(1), exhaled NO, and methacholine PC(20) did not change. However, high dose eotaxin (40 microg) induced an increase in sputum neutrophil count compared with placebo (p<0.05).Inhaled eotaxin up to 40 microg induced no changes in sputum eosinophil count but at 40 microg it increased the sputum neutrophil count. The significance of this finding is unknown.
Ocular Toxicity of Targeted Therapies
Authors: Daniel J. Renouf, Juan P. Velazquez-Martin, Rand Simpson, Lillian L. Siu, Philippe L. Bedard
Journal: Journal of Clinical Oncology (2012)

Molecularly targeted agents are commonly used in oncology practice, and many new targeted agents are currently being tested in clinical trials. Although these agents are thought to be more specific and less toxic then traditional cytotoxic chemotherapy, they are associated with a variety of toxicities, including ocular toxicity. Many of the molecules targeted by anticancer agents are also expressed in ocular tissues. We reviewed the literature for described ocular toxicities associated with both approved and investigational molecularly targeted agents. Ocular toxicity has been described with numerous approved targeted agents and also seems to be associated with several classes of agents currently being tested in early-phase clinical trials. We discuss the proposed pathogenesis, monitoring guidelines, and management recommendations. It is important for oncologists to be aware of the potential for ocular toxicity, with prompt recognition of symptoms that require referral to an ophthalmologist. Ongoing collaboration between oncologists and ocular disease specialists is critical as the use of molecularly targeted agents continues to expand and novel targeted drug combinations are developed.
Should we dump the metabolic syndrome? No
Authors: K G M M Alberti, P Z Zimmet
Journal: BMJ (2008)

The number of people with the metabolic syndrome is rising alongside obesity. Nevertheless, <b>Edwin Gale </b>believes the diagnosis has little practical value. <b>George Alberti </b>and<b> P Z Zimmet, </b>however, think it increases the detection of people at high risk of diabetes and heart disease
Intermediate-Range Sweat Chloride Concentration and Pseudomonas Bronchitis
Authors: Robert C. Stern, Thomas F. Boat, Carlos R. Abramowsky, LeRoy W. Matthews, Robert E. Wood, Carl F. Doershuk
Journal: JAMA (1978)

We studied the clinical and laboratory characteristics of seven patients with sweat chloride concentration consistently between 40 and 60 mEq/liter. Each has chronic Pseudomonas bronchitis, and all lack digestive symptoms. Laboratory findings indicate the preservation of exocrine pancreatic function. The patients include two of five children in one family and two of four in another. In a third family, one of five siblings has an intermediate sweat chloride concentration, but another has a typical fibrosis value (105 mEq/liter). One patient died of respiratory failure; results of an autopsy showed bronchiolectasis typical of cystic fibrosis, but minimal pancreatic changes. The data suggest a genetic basis for this variant of cystic fibrosis. These patients may be homozygous for a portion of a closely linked multigene cystic fibrosis locus or may have modifier genes that ameliorate the pancreatic and sweat lesions.
Greek doctors plan action over government's failure to pay them
Authors: A. O'Dowd
Journal: BMJ (2012)

Doctors in Greece are planning to refuse to treat patients without being paid upfront, after months of government delays in being paid for the work they have done.

A doctors’ trade union issued a statement on 9 August in which it said that its members would take steps if the situation was not resolved by 20 August and that it would seek to take legal action against the Greek government.

The dispute involves doctors working for the state employer, the National Organization for Healthcare Provision (EOPYY), Greece’s equivalent to the NHS.

The doctors claim that their employer has breached its contractual obligations to pay doctors within 45 days of them providing medical services.

The …
Monogenic mutations differentially affect the quantity and quality of T follicular helper cells in patients with human primary immunodeficiencies
Authors: Cindy S. Ma, Natalie Wong, Geetha Rao, Danielle T. Avery, James Torpy, Thomas Hambridge, Jacinta Bustamante, Satoshi Okada, Jennifer L. Stoddard, Elissa K. Deenick, Simon J. Pelham, Kathryn Payne, Stéphanie Boisson-Dupuis, Anne Puel, Masao Kobayashi, Peter D. Arkwright, Sara Sebnem Kilic, Jamila El Baghdadi, Shigeaki Nonoyama, Yoshiyuki Minegishi, Seyed Alireza Mahdaviani, Davood Mansouri, Aziz Bousfiha, Annaliesse K. Blincoe, Martyn A. French, Peter Hsu, Dianne E. Campbell, Michael O. Stormon, Melanie Wong, Stephen Adelstein, Joanne M. Smart, David A. Fulcher, Matthew C. Cook, Tri Giang Phan, Polina Stepensky, Kaan Boztug, Aydan Kansu, Aydan İkincioğullari, Ulrich Baumann, Rita Beier, Tony Roscioli, John B. Ziegler, Paul Gray, Capucine Picard, Bodo Grimbacher, Klaus Warnatz, Steven M. Holland, Jean-Laurent Casanova, Gulbu Uzel, Stuart G. Tangye
Journal: Journal of Allergy and Clinical Immunology (2015)