Letters: CD4+ Lymphocytopenia in Systemic Lupus Erythematosus
Authors: Michael Guma
Journal: Annals of Internal Medicine (1994)

Letters15 January 1994Letters: CD4+ Lymphocytopenia in Systemic Lupus ErythematosusMichael Guma, DO and Randal Krakauer, MDMichael Guma, DOSeton Hall University, School of Graduate Medical Education; South Orange, NJ 07079-2689Search for more papers by this author and Randal Krakauer, MDSeton Hall University, School of Graduate Medical Education; South Orange, NJ 07079-2689Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-2-199401150-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We read with great interest Laurence's review [1] on CD4+ T-lymphocytopenia. We report a case of CD4+ lymphocytopenia in a young woman with systemic lupus erythematosus.A 35-year-old white woman was seen in 1987 reporting recurrent arthralgias, rash, increased hair loss, and the Raynaud phenomena. Her physical examination showed a malar flush, the presence of herpes zoster along the lateral aspect of her abdomen, and synovitis of her wrists and ankles. Laboratory results included: a positive antinuclear antibody count (1:640 homogeneous), an erythrocyte sedimentation rate of 20 mm/h, a moderately positive double-stranded DNA, a normal C3, and ...References1. Laurence J. T-cell subsets in health, infectious disease, and idiopathic CD4+ T Lymphocytopenia. Ann Intern Med. 1993; 119:55-62. Google Scholar2. Duncan RA, Von Reyn CF, Alliegro GM, Toossi Z, Sugar AM, Levitz SM. Idiopathic CD4+ T-lympopenia—four patients with opportunistic infections and no evidence of HIV infection. N Engl J Med. 1993; 328:393-8. Google Scholar3. Spira TJ, Jones BM, Nicholson JK, Lal RB, Rowe T, Mawle AC, et al. Idiopathic CD4+ T-lymphocytopenia—an analysis of five patients with unexplained opportunistic infections. N Engl J Med. 1993; 386-92. Google Scholar4. Smith DK, Neal JJ, Holmberg SD. Unexplained opportunistic infections and CD4+ T-lymphopenia without HIV infection. N Engl J Med. 1993; 328:372-9. Google Scholar5. Winfield JB, Shaw M, Yamada A, Minota S. Subset specificity of antilymphocyte antibodies in systemic lupus erythematosus. II. Preferential reactivity with T4+ cells is associated with relative depletion of autologous T4+ cells. Arthritis Rheum. 1987; 30:162-8. Google Scholar Author, Article, and Disclosure InformationAffiliations: Seton Hall University, School of Graduate Medical Education; South Orange, NJ 07079-2689 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCryptococcal meningitis occurring eight years before a diagnosis of lupus was madeImmunomodulatory effects of a traditional Chinese medicine, Chi-Shie-Shuang-Bu-An-Shen-Tang, on BALB/c miceT cell receptor excision circles (TRECs), CD4 + , CD8 + and their CD45RO + and CD45RA + subpopulations in hepatitis C virus (HCV)-HIV-co-infected patients during treatment with interferon alpha plus ribavirin: analysis in a population on effective antiretroviral therapyIdiopathic CD4 lymphocytopeniaQuantification of absolute peripheral white blood cells and their subsets in patients with lupus erythematosus: comparison with other inflammatory diseases with and without autoimmune backgroundNuclear-Targeting Autoantibodies Induced Nuclear PARP Cleavage Accompanied by More Pronounced Decrease of Peripheral White Blood Cells Than Ro/SSA and La/SSB Antigen-Targeting AutoantibodiesApoptosis: the link between autoantibodies and leuko-/lymphocytopenia in patients with lupus erythematosusLymphocytopenia in a hospital population - what does it signify? 15 January 1994Volume 120, Issue 2Page: 168-169KeywordsAntibodiesDNAHIVLungsLupus erythematosusLymphocytesLymphopeniaMedical risk factorsRashesResearch laboratories Issue Published: 15 January 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...