tbuckley/cabot-search huggingface dataset:
"THERE IS NOTHING PHYSICALLY THE MATTER" (CONTINUED)
Authors: Andrew D. Hart
Journal: JAMA (1941)

<h3>To the Editor:—</h3> Dr. Roy Grinker's communication inThe Journal, October 18, deserves wide attention and comment. The physician's attitude toward patients with nervous symptoms generally reflects discredit on the medical profession. The reasons for that attitude should give us pause. Most physicians have little difficulty in recognizing anxiety states and the various organ neuroses. Even when the diagnosis is made by the exclusion method alone, our correct percentages are satisfactorily high. However, when a diagnosis of psychoneurosis has been established there seems often to be little advice that can be given which is of real or lasting benefit. The patient is usually left more confused than ever, for he is frequently told, against his own better judgment, that "there is nothing physically the matter" or "nothing seriously wrong." Both of these considered opinions are erroneous. Nervous disorders are invariably accompanied by measurable disturbances of physiology. At first functional and
Hemoccult Test-Reply
Authors: Morton J. Goodman
Journal: JAMA (1977)

Dr Hastings may be correct in his observation that we found no colon cancers in our study group using the HO test because none was present. We have analyzed the death rates in Oregon from colo-rectal cancer, the available cancer incidence data, and reports from our tumor registries in the state. On the basis of these data we have predicted that at least two cases of colon cancer were present in our group at the time of our study. We detected none. One woman, aged 66 years, had a large obstructing carcinoma of the ascending colon and cecum 16 months after she participated in our study. (Her three HO tests were negative.) As Dr Hastings suggests, follow-up of at least two years is essential. This follow-up period has been completed in most but not all of our population. Dr Hastings calls attention to the new modification of the
Abstract A53: Genetic analysis of semaphorin 5A and plexin-B3 in human glioma
Authors: Fathima Rifkhana Shah Jahan, Alan Yiu Wah Lee
Journal: Cancer Research (2013)

Abstract Semaphorins are a family of axon guidance molecules, which signal through their co-receptors neuropilins and plexins to subserve various functions in the nervous system, the immune system and during organogenesis. Contrary to their role in development, accumulating evidence suggests the pro- and anti-tumorigenic functions of semaphorins and plexins in different cancer types. Similar to other semaphorins, semaphorin 5A (Sema5A) has recently been implicated in various cancers, though its functions remain ambiguous. Our former study revealed the suppressive effect of Sema5A in glioma cell migration and invasion. Analysis of human glioma specimens revealed a marked down-regulation of Sema5A protein expression in high grade glioblastomas, which are highly infiltrative. Here, we provide evidence that forced expression of Sema5A inhbits glioma cell proliferation by disrupting the cell cycle. Taken together, these findings suggest a tumor suppressor function of Sema5A in glioma. Interestingly, real-time quantitative PCR analysis revealed no significant difference in Sema5A mRNA levels across different grades of glioma. Analysis of Sema5A gene in human glioma specimens detected no mutations but the presence of various alternatively spliced variants that could potentially lead to premature truncation of Sema5A protein. Notably, the predominant Sema5A splice variant is expressed at almost equal level as the wild-type counterpart in the glioma specimens analysed. Ectopic expression of this truncated isoform in fact results in an unstable protein that is targeted for proteasomal degradation. These findings reinforce our hypothesis that reduced Sema5A protein levels in glioblastomas could compromise its suppressive effects in glioma progression. Citation Format: Fathima Rifkhana Shah Jahan, Alan Yiu Wah Lee. Genetic analysis of semaphorin 5A and plexin-B3 in human glioma. [abstract]. In: Proceedings of the Third AACR International Conference on Frontiers in Basic Cancer Research; Sep 18-22, 2013; National Harbor, MD. Philadelphia (PA): AACR; Cancer Res 2013;73(19 Suppl):Abstract nr A53.
Juxtaminorpapillary Diverticulum Associated with Chronic Pancreatitis
Authors: M. Osnes, T. Lötveit
Journal: Endoscopy (1976)

A 69-years-old male with a juxtaminorpapillary diverticulum of Santorini in the duodenum and chronic pancreatitis is described. The patient had suffered from attacks of epigastric pain during the last 35 years. At recent admission to hospital he had also an elevated urinary amylase activity and a juxtaminorpapillary diverticulum, demonstrated by duodenoscopy and X-ray examination after administration of a contrast medium. Endoscopic retrograde cholangio-pancreatography (ERCP) showed changes of the pancreatic duct system compatible with chronic pancreatitis, a diagnosis which was confirmed by explorative laparotomy.
Rhyme and Reason
Authors: Samuel Vaisrub
Journal: JAMA (1978)

If medicine is an art as well as a science, then surely it is not an art for art's sake. Tracing the philosophical roots of medicine to humanism and scientific determinism, Robin (p 2273) concludes that the proper concern of man is man and that of the physician is to help his patient toward a contented and self-sufficient life. Although there does not seem to be anything startling in this conclusion, it carries practical implications that are not obvious at first sight. For instance, it may not be apparent, as Robin points out, that diagnosis is not an end in itself but a means to good treatment. The latter can sometimes be achieved without making a minutely precise diagnosis, particularly if the diagnostic technology is expensive, bothersome, and perhaps even hazardous. The diagnosis may not even be relevant to the patient's central problem. Treatment, too, may be irrelevant to contentment
Stimulation of Lactate Production by Administration of Bicarbonate in a Patient with a Solid Neoplasm and Lactic Acidosis
Authors: Donald S. Fraley, Sheldon Adler, Frank J. Bruns, Barbara Zett
Journal: New England Journal of Medicine (1980)

LACTIC acidosis associated with acute leukemia has been attributed to overproduction of lactic acid by the tumor cells, 1 2 3 whereas lactic acidosis in solid, nonhematologic neoplasia with hepatic involvement is considered to be due to reduced hepatic use of lactate.4 Severe lactic acidosis is usually treated by administration of bicarbonate. This report describes a patient who had lactic acidosis and an anaplastic large-cell tumor involving the bone marrow. Bicarbonate therapy failed to improve the blood bicarbonate concentration in this patient, but, instead, increased lactic acid production. Reduced bicarbonate administration lowered lactic acid production and simplified his care.Case ReportAn 81-year-old . . .
The Use of Vismodegib to Shrink Keratocystic Odontogenic Tumors in Patients With Basal Cell Nevus Syndrome
Authors: Mina S. Ally, Jean Y. Tang, Timmy Joseph, Bobbye Thompson, Joselyn Lindgren, Maria Acosta Raphael, Grace Ulerio, Anita M. Chanana, Julian M. Mackay-Wiggan, David R. Bickers, Ervin H. Epstein
Journal: JAMA Dermatology (2014)

Keratocystic odontogenic tumors (KCOTs) of the jaw affect more than 65% of patients with basal cell nevus syndrome (BCNS). Surgery frequently causes facial disfigurement and is not always curative. Most BCNS-related and some sporadic KCOTs have malignant activation of the Hedgehog signaling pathway.We examined the effect of vismodegib (an oral Hedgehog pathway inhibitor) on KCOT size in patients with BCNS enrolled in a clinical trial testing vismodegib for basal cell carcinoma prevention (NCT00957229), using pretreatment and posttreatment magnetic resonance imaging. Four men and 2 women had pretreatment KCOTs (mean longest diameter, 2.0 cm; range, 0.7-3.3 cm), occurring primarily in the mandible. Patients were treated with vismodegib, 150 mg/d, for a mean (SD) of 18.0 (4.8) months (range, 11-24 months). Four patients experienced a size reduction and 2 had no change. Vismodegib reduced the mean longest diameter of KCOTs in all patients by 1.0 cm (95% CI, 0.03-1.94; P = .02) or 50% from baseline. We observed no enlargement of existing KCOTs or new KCOT development.Vismodegib shrinks some KCOTs in patients with BCNS and may offer an alternative to surgical therapy. These effects were maintained for at least 9 months after drug cessation in 1 patient. Further studies assessing long-term efficacy and optimal maintenance regimens should be performed.
Chromium on the Hands of Children After Playing in Playgrounds Built from Chromated Copper Arsenate (CCA)–Treated Wood
Authors: Camille Hamula, Zhongwen Wang, Hongquan Zhang, Elena Kwon, Xing-Fang Li, Stephan Gabos, X. Chris Le
Journal: Environmental Health Perspectives (2005)

Children's exposure to arsenic and chromium from playground equipment constructed with chromated copper arsenate (CCA)-treated wood is a potential concern because of children's hand-to-mouth activity. However, there exists no direct measure of Cr levels on the hands of children after playing in such playgrounds. In this study we measured both soluble and total Cr on the hands of 139 children playing in playgrounds, eight of which were constructed with CCA-treated wood and eight of which were not. Children's age and duration of play were recorded. The hands of each child were washed after play with 150 mL deionized water, which was collected in a bag and subsequently underwent analysis of Cr and 20 other elements, using inductively coupled plasma mass spectrometry. Total average Cr on the hands of 63 children who played in CCA playgrounds was 1,112 +/- 1,089 ng (median, 688; range 78-5,875). Total average Cr on the hands of 64 children who played in non-CCA playgrounds was 652 +/- 586 ng (median, 492; range 61-3,377). The difference between the two groups is statistically significant (p < 0.01). Cr levels were highly correlated to both Cu (r = 0.672) and As (r = 0.736) levels in CCA playgrounds (p < or = 0.01), but not non-CCA playgrounds (r = 0.252 and 0.486 for Cu and As, respectively). Principal-component analysis indicates that Cr, Cu, and As are more closely grouped together in CCA than in non-CCA playgrounds. These results suggest that the elevated levels of Cr and As on children's hands are due to direct contact with CCA wood.
Foreign body inhalation in children
Authors: K. Wang, A. Harnden, A. Thomson
Journal: BMJ (2010)

Children, especially toddlers, tend to place objects in their mouths while exploring their environment. They are therefore at increased risk of inhaling foreign bodies, which may become lodged in the tracheobronchial system. 

#### Case scenario

A 2 year old boy presented to his general practitioner with a two week history of a dry, persistent cough. His mother recalled an episode two weeks ago when he had a violent coughing fit while eating nuts and raisins. She took him to the nearest hospital emergency department, but he was discharged a few hours later after a normal physical examination and normal chest radiograph. Nevertheless, this history of persistent cough following a choking episode should raise concern about possible foreign body inhalation.

#### How common is it?

Diagnosis of an inhaled foreign body was delayed by more than a week in 29% of cases …
Detection of expiratory flow limitation during mechanical ventilation.
Authors: P Valta, C Corbeil, A Lavoie, R Campodonico, N Koulouris, M Chassé, J Braidy, J Milic-Emili
Journal: American Journal of Respiratory and Critical Care Medicine (1994)

Two new methods, application of negative pressure at the airway opening during expiration (NEP) and reduction of flow resistance by bypassing the expiratory line of the ventilator by exhaling into the atmosphere (ATM), were used to detect expiratory flow limitation in 12 semirecumbent (45 degree) mechanically ventilated patients, seven with chronic airway obstruction (CAO). An increase of expiratory flow with NEP or ATM, relative to the preceding control breath, was taken as indicating absence of expiratory flow limitation. By contrast, the portion of the tidal expiration over which there was no change in flow with NEP or ATM was considered as flow-limited. With NEP, nine patients exhibited flow limitation, six (all with CAO) were flow-limited over most of the tidal expiration (> 70% VT), and three at < 60% VT. Although the results with NEP and ATM were in general in good agreement, in the three non-flow-limited patients the ATM method gave erroneous results. Six patients were also studied supine, including two who were not flow-limited when semirecumbent: both became flow-limited when supine. We conclude that NEP provides a simple method to detect flow limitation in mechanically ventilated patients. The supine position enhances flow limitation.
STREPTOCOCCIC SEPTICEMIA OF HEMATOGENOUS ORIGIN IN A NEW-BORN INFANT
Authors: Joseph A. Ritter
Journal: JAMA (1933)

Recently Dunham<sup>1</sup>reported thirty-nine cases of septicemia in the new-born, fifteen of which were due to the streptococcus organism. Of the latter, fourteen were of the hemolytic group and one was of the nonhemolytic group. In three cases the mother's blood also harbored the streptococci. Dunham's fifteen cases and the eight she found in the literature terminated fatally. Hemorrhage did not occur in any of her cases of streptococcic septicemia, while in our case there was a terminal pulmonary hemorrhage sixteen hours after birth. The report of this single case is of interest because of the hemorrhage encountered and because of the positive antemortem blood cultures obtained from the mother after positive postmortem cultures were obtained from blood in the heart and lungs of the infant. To show the hematogenous origin of the septicemia, we are including pertinent facts concerning the mother. <h3>REPORT OF CASE</h3> Mrs. A. N., a
Reversion From Precore/Core Promoter Mutants to Wild-Type Hepatitis B Virus During the Course of Lamivudine Therapy
Authors: Sung Won Cho, Ki-Baik Hahm, Jin Hong Kim
Journal: Hepatology (2000)

The effect of lamivudine administration on the evolution of precore/core promoter mutation is unknown. The aim of this study was to determine the changes of precore/core promoter sequences in chronic type B hepatitis patients treated with lamivudine. Serial sera were obtained from 11 patients before, at the beginning of, and during therapy. Serum samples were polymerase chain reaction-amplified, and nucleotide sequences of hepatitis B virus (HBV) were analyzed. At baseline, precore and core promoter mutations were found in 6 and 4 of 11 patients, respectively. A precore stop codon mutant was replaced by a wild-type virus in all 6 patients infected with precore mutant at a median treatment of 12 months (vs. before therapy; P =.011). Mutations in the core promoter appeared in only 1 of 10 patients (vs. before therapy; P =.021). However, precore and core promoter mutations appeared in 5 and 7 of 10 patients at a median treatment of 21 months, respectively. Acute exacerbation occurred after lamivudine withdrawal in 2 patients who had hepatitis B e antigen (HBeAg) loss or seroconversion. The serum remained HBeAg-negative throughout the study period, and each of 2 patients had precore wild-type virus during acute exacerbation. HBV mutants with core gene deletions are not eliminated completely during prolonged therapy in 2 patients in whom the HBV genomes had core gene deletions at baseline. In conclusion, lamivudine therapy resulted in reversion from precore/core promoter mutants to wild-type. However, mutations in the precore and core promoter region reappeared during prolonged therapy. HBeAg-negative wild-type precore hepatitis B virus could be selected after lamivudine withdrawal in patients who had HBeAg loss or seroconversion.
Iron deficiency in children.
Authors: A. Mills
Journal: BMJ (1989)

In this series of patients the anteroposterior projection provided no useful information.Al- though cervical ribs are only occasionally symptomatic, they are not reliably seen in a lateral film.An anteroposterior film that includes the lung apices may very occasionally show a Pancoast tumour in patients with symptoms in the arms.For patients with neck symptoms alone routine cervical spine radiography could justifiably comprise a lateral projection alone in the first instance.For those with symptoms in the arms or with other reasons for referral further projections are desirable as a routine.
Nicotine Dependence and WHO Mental Health Surveys
Authors: John R. Hughes
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Two-in-One Antibody against HER3 and EGFR Has Superior Inhibitory Activity Compared with Monospecific Antibodies
Authors: Gabriele Schaefer, Lauric Haber, Lisa M. Crocker, Steven Shia, Lily Shao, Donald Dowbenko, Klara Totpal, Anne Wong, Chingwei V. Lee, Scott Stawicki, Robyn Clark, Carter Fields, Gail D. Lewis Phillips, Rodney A. Prell, Dimitry M. Danilenko, Yvonne Franke, Jean-Philippe Stephan, Jiyoung Hwang, Yan Wu, Jenny Bostrom, Mark X. Sliwkowski, Germaine Fuh, Charles Eigenbrot
Journal: Cancer Cell (2011)
C-REACTIVE PROTEIN AS A RISK FACTOR FOR FUTURE CARDIOVASCULAR EVENTS IN PATIENTS WITH STEMI AND NORMAL OR MILDLY IMPAIRED LEFT VENTRICLE SYSTOLIC FUNCTION
Authors: Georgios Lazaros, Dimitris Tousoulis, Gerasimos Siasos, Evangelos Oikonomou, Konstantinos Maniatis, Marina Zaromitidou, Stamatios Kioufis, Eleni Kokkou, Nikolaos Papageorgiou, Constantina Aggeli, Christine Chrysohoou, Manolis Vavuranakis, Georgios Zakynthinos, Athanasios Papavassiliou, Christodoulos I Stefanadis
Journal: Journal of the American College of Cardiology (2013)
The clinical spectrum of Sweet's syndrome (acute febrile neutrophilic dermatosis)—a report of eighteen cases
Authors: D.A. GUNAWARDENA, K.A. GUNAWARDENA, R.M.R.S. RATNAYAKA, N.S. VASANTHANATHAN
Journal: British Journal of Dermatology (1975)

Journal Article The clinical spectrum of Sweet's syndrome (acute febrile neutrophilic dermatosis)—a report of eighteen cases Get access D.A. GUNAWARDENA, D.A. GUNAWARDENA The General Hospital, Kandy, Sri‐Lanka Reprint requests to Dr D.A.Gunawardena, General Hospital, Kandy, Sri‐Lanka Search for other works by this author on: Oxford Academic Google Scholar K.A. GUNAWARDENA, K.A. GUNAWARDENA the University of Sri‐Lanka, Peradeniya, Sri‐Lanka Search for other works by this author on: Oxford Academic Google Scholar R.M.R.S. RATNAYAKA, R.M.R.S. RATNAYAKA the University of Sri‐Lanka, Peradeniya, Sri‐Lanka Search for other works by this author on: Oxford Academic Google Scholar N.S. VASANTHANATHAN N.S. VASANTHANATHAN The General Hospital, Kandy, Sri‐Lanka Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 92, Issue 4, 1 April 1975, Pages 363–373, https://doi.org/10.1111/j.1365-2133.1975.tb03095.x Published: 01 April 1975 Article history Accepted: 05 July 1974 Published: 01 April 1975
Vaccine Treatment of Measles
Authors: A. A. Cunningham
Journal: BMJ (1937)

first pregnancy.Spontaneous labour occurred at thirty-six weeks, with a difficult breech delivery.The baby was some- what shocked, and weighed 4 lb. 15oz. at birth.On discharge at 2 weeks his weight was 5 lb. 4 oz.Case 11.-Baby boy.Normal healthy parents.Spon- taneous delivery at thirty-five weeks.His weight was 5 lb.3{ oz. at birth, 5 lb. 5 oz. at 2 weeks, and 8 lb. 12 oz.,,at 2 months.Table of Resiults (No Deaths) Weight Case Sex Weight Age Discharge No.At Birth On Discharge I Girl 4 lb.7i oz. 4 lb.7j oz. 2 weeks 2 ,, 3 lb.IO oz. 3 lb.101 oz. 2 , 3 ,, 3 lb. 12oz. 3lb.14 oz. 4 + operation 4 , 3 lb.12 oz.3 lb.10 oz. 2 5 4 lb.8 oz. 5 lb.O oz. 2 6 Boy 3 lb.13 oz.4 lb. 1 oz.21 7 Girl 3 lb.8 oz.41b.2l oz.21 ,, 8 4 lb.7j oz. 4 lb.12 oz. 2 9 ,, 4 lb.ij oz. 4 lb.7l oz. 2 10 Boy 41b.15oz.5ib.4oz. 2 11 ,, Slb.3l oz.S lb. 5 oz. 2 Summary Details are given of eleven premature and one sick baby treated with progynon.This preparation of oestrin, given orally, appears definitely helpful to premature in- fants.The babies cause less anxiety.The feeds are taken better; the initial loss of weight appears less and is usually made up sooner.No baby to whom it was given died.
Response to Open Peer Commentaries on “Returning to History: The Ethics of Researching Asylum Seeker Health in Australia”
Authors: Deborah Zion, Linda Briskman, Bebe Loff
Journal: The American Journal of Bioethics (2010)

"Response to Open Peer Commentaries on “Returning to History: The Ethics of Researching Asylum Seeker Health in Australia”." The American Journal of Bioethics, 10(2), pp. W6–W7
Picosecond Laser Pulses for Tattoo Removal: A Good, Old Idea
Authors: Omar A. Ibrahimi, Fernanda H. Sakamoto, R. Rox Anderson
Journal: JAMA Dermatology (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
OPERATIONS FOR THE RADICAL CURE OF HERNIA IN PERSONS OVER SIXTY YEARS OF AGE.
Authors: A. E. ROCKEY
Journal: JAMA (1897)

<h3>Illustrative case.</h3> —Man aged 72. Ruptured forty years. Retention with truss always difficult ahd painful. For two years the hernia had not been reduced and had grown to enormous size. During examination the intestinal portion, representing about three fourths of its bulk, was reduced by taxis with some difficulty but an omental portion remained irreducible. A truss was adjusted but the hernia could not be retained. The man had chronic bronchitis and the paroxsyms of coughing soon sent the intestine under the truss. Radical cure by operation was recommended and accepted. Previous to operation the patient was kept in bed for two days and the cough much allayed by an anodyne mixture. Chloroform was administered, the sac opened and a large mass of omentum, the lower end of which was firmly incarcerated in a small pouch, was removed after ligation with fine silk. The operation was finished after the manner