tbuckley/cabot-search huggingface dataset:
Predictors of Severe Right Ventricular Failure After Implantable Left Ventricular Assist Device Insertion: Analysis of 245 Patients
Authors: Yoshie Ochiai, Patrick M. McCarthy, Nicholas G. Smedira, Michael K. Banbury, Jose L. Navia, Jingyuan Feng, Amy P. Hsu, Michael L. Yeager, Tiffany Buda, Katherine J. Hoercher, Michael W. Howard, Masami Takagaki, Kazuyoshi Doi, Kiyotaka Fukamachi
Journal: Circulation (2002)

Insertion of an implantable left ventricular assist device (LVAD) complicated by early right ventricular (RV) failure has a poor prognosis and is largely unpredictable. Prediction of RV failure after LVAD placement would lead to more precise patient selection and optimal device selection.We reviewed data from 245 patients (mean age, 54+/-11 years; 85% male) with 189 HeartMate (77%) and 56 Novacor (23%) LVADs. Ischemic cardiomyopathy predominated (65%), and 29% had dilated cardiomyopathy. Overall, RV assist device (RVAD) support was required after LVAD insertion for 23 patients (9%). We compared clinical and hemodynamic parameters before LVAD insertion between RVAD (n=23) and No-RVAD patients (n=222) to determine preoperative risk factors for severe RV failure. By univariate analysis, female gender, small body surface area, nonischemic etiology, preoperative mechanical ventilation, circulatory support before LVAD insertion, low mean and diastolic pulmonary artery pressures (PAPs), low RV stroke work (RVSW), and low RVSW index (RVSWI) were significantly associated with RVAD use. Elevated PAP and pulmonary vascular resistance were not risk factors. Risk factors by multivariable logistic regression were preoperative circulatory support (odds ratio [OR], 5.3), female gender (OR, 4.5), and nonischemic etiology (OR, 3.3).The need for circulatory support, female gender, and nonischemic etiology were the most significant predictors for RVAD use after LVAD insertion. Regarding hemodynamics, low PAP and low RVSWI, reflecting low RV contractility, were important parameters. This information may lead to better patient selection for isolated LVAD implantation.
Induction of Monocyte Chemoattractant Protein-1 in the Small Veins of the Ischemic and Reperfused Canine Myocardium
Authors: Ajith G. Kumar, Christie M. Ballantyne, Lloyd H. Michael, Gilbert L. Kukielka, Keith A. Youker, Merry L. Lindsey, Hal K. Hawkins, Holly H. Birdsall, Charles R. MacKay, Gregory J. LaRosa, Roger D. Rossen, C. Wayne Smith, Mark L. Entman
Journal: Circulation (1997)

Background Healing after myocardial infarction is characterized by the presence of macrophages in the infarcted area. Since augmented monocyte influx has been implicated as a potential mechanism for improved healing after reperfusion, we wished to study the induction of monocyte chemoattractant protein-1 (MCP-1) during reperfusion. Methods and Results The cDNA for MCP-1 was cloned from a canine jugular vein endothelial cell (CJVEC) library and exhibited 78% identity with the deduced amino acid sequence of human MCP-1. Samples of myocardium were taken from control and ischemic segments after 1 hour of ischemia and various times of reperfusion; total RNA was isolated from myocardial samples and probed with a cDNA probe for canine MCP-1. Induction of MCP-1 mRNA occurred only in previously ischemic segments within the first hour of reperfusion, peaked at 3 hours, and persisted throughout the first 2 days of reperfusion. In the absence of reperfusion, no significant MCP-1 induction was seen. Both ischemic (but not preischemic) cardiac lymph and human recombinant TNF-α induced MCP-1 in CJVECs. MCP-1 was identified by immunostaining on infiltrating cells and venular (but not arterial) endothelium by 3 hours. In contrast, in situ hybridization showed MCP-1 mRNA to be confined to the endothelium of small veins (venules) 10 to 70 μm in diameter. Conclusions MCP-1 mRNA is induced in the endothelium of a specific class of small veins immediately after reperfusion. MCP-1 induction is confined to the previously ischemic area that has been reperfused. We suggest a significant role for MCP-1 in monocyte trafficking in the reperfused myocardium.
Immediate contact reactions to chemicals in the fragrance mix and a study of the quenching action of eugenol
Authors: R.J. SAFFORD, D.A. BASKETTER, C.F. ALLENBY, B.F.J. GOODWIN
Journal: British Journal of Dermatology (1990)

In this study, the nature of non-immune immediate contact reactions (NIICR) produced by cinnamic aldehyde, benzoic acid and sorbic acid were investigated, with particular interest in the 'quenching' ability of eugenol. Three groups of human subjects were studied, and the guinea-pig ear was also used as a model of NIICR. Cinnamic aldehyde, benzoic acid and sorbic acid were all able to produce NIICR in the majority of subjects studied. There was a strong correlation between the susceptibility of each subject to each urticant, but no correlation between the susceptibility to NIICR and age, atopic status or tanning ability. Eugenol caused a reduction in NIICR induced by all three urticants. This 'quenching' effect was apparent even when the eugenol was applied up to 60 min prior to application of cinnamic aldehyde, and its effect was not eliminated by washing. In the guinea-pig-ear model, ear thickening was induceed by all three urticants, and this response was inhibited by eugenol.
Clozapine, Olanzapine, Risperidone, and Haloperidol in the Treatment of Patients With Chronic Schizophrenia and Schizoaffective Disorder
Authors: Jan Volavka, Pal Czobor, Brian Sheitman, Jean-Pierre Lindenmayer, Leslie Citrome, Joseph P. McEvoy, Thomas B. Cooper, Miranda Chakos, Jeffrey A. Lieberman
Journal: American Journal of Psychiatry (2002)

The authors compared the efficacy and safety of three atypical antipsychotics (clozapine, olanzapine, and risperidone) with one another and with haloperidol in the treatment of patients with chronic schizophrenia or schizoaffective disorder.In a double-blind trial, 157 inpatients with a history of suboptimal treatment response were randomly assigned to treatment with clozapine, olanzapine, risperidone, or haloperidol for 14 weeks (an 8-week escalation and fixed-dose period followed by a 6-week variable-dose period).Clozapine, risperidone, and olanzapine (but not haloperidol) resulted in statistically significant improvements in total score on the Positive and Negative Syndrome Scale. Improvements seen in total and negative symptom scores with clozapine and olanzapine were superior to haloperidol. The atypical drugs, particularly olanzapine and clozapine, were associated with weight gain.The effects of atypical antipsychotics in this population were statistically significant but clinically modest. The overall pattern of results suggests that clozapine and olanzapine have similar general antipsychotic efficacy and that risperidone may be somewhat less effective. Clozapine was the most effective treatment for negative symptoms. However, the differences among treatments were small.
The Calcimimetic AMG 073 as a Potential Treatment for Secondary Hyperparathyroidism of End-Stage Renal Disease
Authors: L. Darryl Quarles, Donald J. Sherrard, Stephen Adler, Steven J. Rosansky, Laura C. McCary, Wei Liu, Stewart A. Turner, David A. Bushinsky
Journal: Journal of the American Society of Nephrology (2003)

Current treatment of secondary hyperparathyroidism in chronic kidney failure with calcium and active vitamin D is potentially limited by hypercalcemia and hyperphosphatemia. AMG 073 represents a new class of compounds for the treatment of hyperparathyroidism known as calcimimetics, which reduce parathyroid hormone (PTH) synthesis and secretion by increasing the sensitivity of the parathyroid calcium-sensing receptor (CaR) to extracellular calcium. The current study evaluates the efficacy and safety of AMG 073 when added to conventional treatment of secondary hyperparathyroidism in end-stage renal disease (ESRD). Seventy-one hemodialysis patients with uncontrolled secondary hyperparathyroidism, despite standard therapy with calcium, phosphate binders, and active vitamin D sterols, were treated in this 18-wk, dose-titration study with single daily oral doses of AMG 073/placebo up to 100 mg. Changes in plasma PTH, serum calcium, serum phosphorus, and calcium x phosphorus levels were compared between AMG 073 and placebo groups. Mean PTH decreased by 33% in the AMG 073 patients compared with an increase of 3% in placebo patients (P = 0.001). A significantly greater proportion of AMG 073 patients (44%) had a mean PTH < or = 250 pg/ml compared with placebo patients (20%; P = 0.029). Also, a significantly greater proportion of AMG 073 patients (53%) had a decrease in PTH > or =30% compared with placebo patients (23%; P = 0.009). Calcium x phosphorus levels decreased by 7.9% in AMG 073 patients compared with an increase of 11.3% in placebo patients (P = 0.013). Adverse event rates were low and mostly mild to moderate in severity; however, the incidence of vomiting was higher in AMG 073 patients. In this study, the calcimimetic AMG 073 at doses up to 100 mg for 18 wk provided a safe and effective means to attain significant reductions in PTH and calcium x phosphorus levels in ESRD patients. AMG 073 represents a novel and promising therapy to improve the management of secondary hyperparathyroidism.
Home Urine C-Peptide Creatinine Ratio Can Be Used to Monitor Islet Transplant Function
Authors: Richard A. Oram, Augustin M. Brooks, Shareen Forbes, Stephanie Eckoldt, Richard M. Smith, Pratik Choudhary, Miranda J. Rosenthal, Paul Johnson, Martin K. Rutter, Keith A. Burling, Timothy J. McDonald, James A.M. Shaw, Andrew T. Hattersley
Journal: Diabetes Care (2014)

OBJECTIVE Islet graft function is defined by serum C-peptide in a standardized challenge test. We assessed whether urine C-peptide creatinine ratio (UCPCR) sent from home could provide a viable alternative. RESEARCH DESIGN AND METHODS Seventeen islet recipients provided 90-min serum C-peptide (sCP90) and 120-min UCPCR (UCPCR120) samples during 68 interval posttransplant mixed-meal tolerance tests, also posting from home a 120-min postbreakfast UCPCR sample every 2 weeks. UCPCR was compared with a clinical score of islet function, derived from HbA1c and insulin dose. RESULTS UCPCR120 and mean home postmeal UCPCR were strongly correlated with sCP90 (rs = 0.73, P &amp;lt; 0.001; and rs = 0.73, P &amp;lt; 0.01, respectively). Mean home UCPCR increased with clinical score (rs = 0.75; P &amp;lt; 0.001) and with graft function defined both by sCP90 &amp;gt;200 pmol/L and insulin independence. UCPCR cutoffs to detect insulin independence and poor graft function were sensitive and specific. CONCLUSIONS Home UCPCR provides a valid measure of C-peptide production in islet transplant recipients.
17β-Estradiol Up-regulates the Insulin-like Growth Factor Receptor through a Nongenotropic Pathway in Prostate Cancer Cells
Authors: Giuseppe Pandini, Marco Genua, Francesco Frasca, Sebastiano Squatrito, Riccardo Vigneri, Antonino Belfiore
Journal: Cancer Research (2007)

Abstract Prostate carcinomas frequently express estrogen receptors (ER), irrespective of androgen receptor (AR) expression; however, the role of ERs and estrogens in prostate cancer is controversial. We found that 17β-estradiol (E2) is able to markedly up-regulate insulin-like growth factor (IGF)-I receptor (IGF-IR) mRNA and protein expression in both AR-positive (LNCaP cells) and AR-negative (PC-3 cells) prostate cancer cells. This effect occurs not only via ERα but also via ERβ stimulation and is specific for IGF-IR because it does not involve the cognate insulin receptor. IGF-IR up-regulation is associated with increased IGF-IR phosphorylation and with increased mitogenic and motogenic activities in response to IGF-I. IGF-IR up-regulation by E2 does not require ER binding to DNA and is poorly sensitive to antiestrogen blockade, whereas it is associated with the activation of cytosolic kinase cascades involving Src, extracellular signal–regulated kinase (ERK)-1/2, and, to a lesser extent, phosphatidylinositol 3-kinase and is sensitive to the inhibition of these kinases. In conclusion, our data indicate that estrogens may contribute to IGF system deregulation in prostate cancer through the activation of a nongenotropic pathway. Estrogens may have a role, therefore, in tumor progression to androgen independence. Inhibition of the IGF-IR or the Src-ERK pathway should be considered, therefore, as an adjuvant therapy in prostate cancer. [Cancer Res 2007;67(18):8932–41]
Biochemical Recurrence Following Robot-Assisted Radical Prostatectomy: Analysis of 1384 Patients with a Median 5-year Follow-up
Authors: Mani Menon, Mahendra Bhandari, Nilesh Gupta, Zhaoli Lane, James O. Peabody, Craig G. Rogers, Jesse Sammon, Sameer A. Siddiqui, Mireya Diaz
Journal: European Urology (2010)
Colorado IDDM Registry: Incidence and Validation of IDDM in Children Aged 0–17 Yr
Authors: Richard F Hamman, Elizabeth C Gay, Karen J Cruickshanks, Magdalena Cook, Dennis C Lezotte, Georgeanna J Klingensmith, H Peter Chase
Journal: Diabetes Care (1990)

The purpose of this study was to determine the incidence of insulin-dependent diabetes mellitus (IDDM) among children aged 0–17 yr for age, sex, season, and urban and rural residence of onset in Colorado. Retrospective registration of new-onset cases was conducted from 1978 to 1980, and then prospective registration continued through 1983 with the use of physician reporting with hospital validation. The annual incidence of IDDM was 15.2/100,000 per year (95% confidence interval [Cl] 14.1, 16.3), with little difference between the sexes. The highest incidence was in the 10- to 14-yr age-group for both sexes. There was a seasonal peak of winter onset in those aged 10–17 yr, with similar patterns between sex and ethnic groups. No temporal trend over the 6 yr was seen, although an excess of cases was seen for 15- to 17-yr-old boys in 1980–1982. Rates were similar for urban and rural areas of the state. Case ascertainment was estimated to be 93.2% complete (95% Cl 91.5, 95.5). Incidence was similar in Colorado to other populations in the United States at similar latitudes. These data serve as a baseline for evaluation of changes in incidence over time, by region, and for the identification of possible outbreaks.
Transient outward current prominent in canine ventricular epicardium but not endocardium.
Authors: S H Litovsky, C Antzelevitch
Journal: Circulation Research (1988)

Previous studies have denied the presence of a transient outward current (Ito) in ventricular myocardium of dog, sheep, and calf. Using conventional microelectrode techniques, we provide evidence for a significant contribution of Ito to epicardial, but not endocardial, activity of canine ventricular myocardium. The epicardial action potential when compared with that of endocardium shows a smaller phase 0 amplitude, a much more prominent phase 1, and a phase 2 amplitude that is greater than that of phase 0. Epicardial action potentials, unlike those of endocardium, display a "spike and dome" morphology that becomes progressively more accentuated at slower stimulation rates. Using the restitution of phase 1 amplitude as a marker for the process responsible for the spike and dome phenomenon, we were able to delineate two exponential components: 1) a slow component that recovers with a time constant of 350-570 msec and 2) a fast component with a time constant of 41-85 msec. The slow component was largely abolished by 1-5 mM 4-aminopyridine, an Ito blocker. The fast component was diminished by 4-aminopyridine, but it was also inhibited by ryanodine and by Sr2+ replacement of Ca2+, which are interventions known to inhibit the Ca2+-activated component of Ito. Following 4-aminopyridine and Sr2+ or ryanodine treatment, the epicardial responses more closely resembled those of endocardium. In summary, the data demonstrate a marked heterogeneity of active membrane properties in canine ventricular muscle. These observations may aid in understanding the basis for rate-dependent changes in the T wave of the ECG, supernormal conduction in ventricular muscle, the greater sensitivity of epicardium to ischemia, and the rate dependence of some cardiac arrhythmias.
Identification of a 40S Ribosomal Protein S4–Derived H-Y Epitope Able to Elicit a Lymphoblast-Specific Cytotoxic T Lymphocyte Response
Authors: Roman Ivanov, Tineke Aarts, Samantha Hol, Angeline Doornenbal, Anton Hagenbeek, Eefke Petersen, Saskia Ebeling
Journal: Clinical Cancer Research (2005)

Abstract Purpose: The superior graft-versus-leukemia (GVL) effect of the female-to-male stem cell transplantation is partially independent from the concomitant graft-versus-host reactivity. However, the antigenic basis of this selective GVL response remains enigmatic, because no H-Y antigens with hematopoietic-restricted expression were identified. In this study, we report a novel H-Y epitope that is preferentially recognized on activated proliferating lymphocytes. Experimental Design: We generated a CTL clone YKIII.8 that showed reactivity toward male B*5201+ CD40-activated B cells, EBV-lymphoblastoid cell lines, and phytohemagglutinin-activated T-cell blasts but little or no reactivity toward fibroblasts, CD14+ cells, or unstimulated B and T cells. The antigen recognized by YKIII.8 was identified by screening of a cDNA expression library, and its pattern of expression was investigated. Results: cDNA of the male isoform of 40S ribosomal protein S4 was found to encode the antigenic peptide TIRYPDPVI, which was recognized by YKIII.8. Western blot analysis showed that rapidly proliferating cells overexpress the RPS4 protein in comparison with nonrecognized cell subsets. Retroviral transfer of YKIII.8 T-cell receptor resulted in preservation of the lymphoblast-specific reactivity pattern. Conclusion: Our findings suggest that CTL specific to certain epitopes of ubiquitously expressed H-Y antigens may specifically target lymphoblasts, contributing to the selective GVL effect of female-to-male stem cell transplantation.
Influenza Infection Promotes Macrophage Traffic Into Arteries of Mice That Is Prevented by D-4F, an Apolipoprotein A-I Mimetic Peptide
Authors: Brian J. Van Lenten, Alan C. Wagner, G.M. Anantharamaiah, David W. Garber, Michael C. Fishbein, Lopa Adhikary, Debi P. Nayak, Susan Hama, Mohamad Navab, Alan M. Fogelman
Journal: Circulation (2002)

We reported that HDL loses its antiinflammatory properties during acute influenza A infection in mice, and we hypothesized that these changes might be associated with increased trafficking of macrophages into the artery wall. The present study tested this hypothesis.D-4F, an apolipoprotein A-I mimetic peptide, or vehicle in which it was dissolved (PBS) was administered daily to LDL receptor-null mice after a Western diet and after influenza infection. D-4F treatment increased plasma HDL cholesterol and paraoxonase activity compared with PBS and inhibited increases in LDL cholesterol and peak levels of interleukin-6 after infection. Lung viral titers were reduced by 50% in mice receiving D-4F. Injection of female mice with male macrophages, which were detected with real-time polymerase chain reaction to measure the male Sry gene, revealed a marked increase in macrophage traffic into the aortic arch and innominate arteries after infection that was prevented by administration of D-4F.We conclude that loss of antiinflammatory properties of HDL after influenza infection in mice is associated with increased arterial macrophage traffic that can be prevented by administration of D-4F.
Accuracy of identification of patients with immune thrombocytopenic purpura through administrative records: A data validation study
Authors: Jodi B. Segal, Neil R. Powe
Journal: American Journal of Hematology (2003)

Abstract Administrative data are commonly used to estimate the prevalence of a disease, but the validity of the coding system needs to be evaluated before its use. We assessed the validity of the International Classification of Disease, 9 th version, Clinical Modification (ICD‐9‐CM) code of 287.3 for identifying patients with immune thrombocytopenic purpura (ITP). Administrative data from inpatients and outpatients seen were retrieved if the patient or insurer was billed with one of three ICD‐9‐CM codes for thrombocytopenic disorders, 287.3, 287.4, and 287.5, as a primary or secondary diagnosis; or was physician‐identified as having ITP. The electronic medical records for these patients were systematically reviewed to identify patients with ITP and with non‐ITP diagnoses. Sensitivity, specificity, positive and negative predictive values, and κ scores were calculated separately for inpatients and outpatients. Four‐hundred eighteen records were reviewed. Among inpatients, the sensitivity of code 287.3 for indicating a diagnosis of ITP was 100% [95% confidence interval 94–100%]. The specificity was 89% [95% confidence interval 84–94%]. The percent agreement was 92%, and the κ statistic was 0.80. For outpatients, the sensitivity of the billing code 287.3 was 84% [95% confidence interval 76–91%], a conservative estimate because of how the patients with other diagnoses were selected. The specificity for outpatients was 66% [95% confidence interval 56–76%]. ICD‐9‐CM code 287.3 in administrative billing data is likely to be sufficiently sensitive and specific, particularly when inpatient data are used, for the estimation of the prevalence of ITP. Am. J. Hematol. 75:12–17, 2004. © 2003 Wiley‐Liss, Inc.
Validating the Measurement of Real-World Functional Outcomes: Phase I Results of the VALERO Study
Authors: Philip D. Harvey, Tenko Raykov, Elizabeth W. Twamley, Lea Vella, Robert K. Heaton, Thomas L. Patterson
Journal: American Journal of Psychiatry (2011)

Real-world functional outcomes in people with schizophrenia, rated with an array of preselected rating scales and using information from the patient and an informant and condensed into a judgment rating by the examiner, were globally related to performance-based assessments of ability.
Histopathologic Analysis of Peritumoral Pseudocapsule and Surgical Margin Status after Tumor Enucleation for Renal Cell Carcinoma
Authors: Andrea Minervini, Claudio di Cristofano, Alberto Lapini, Marco Marchi, Federico Lanzi, Gianluca Giubilei, Nicola Tosi, Agostino Tuccio, Massimiliano Mancini, Carlo della Rocca, Sergio Serni, Generoso Bevilacqua, Marco Carini
Journal: European Urology (2008)