Familial Lymphoproliferative Malignancy: Clinical and Laboratory Follow-Up
Authors: WILLIAM A. BLATTNER
Journal: Annals of Internal Medicine (1979)

Brief Reports1 June 1979Familial Lymphoproliferative Malignancy: Clinical and Laboratory Follow-UpWILLIAM A. BLATTNER, M.D., JACK H. DEAN, Ph.D., JOSEPH F. FRAUMENI Jr., M.D.WILLIAM A. BLATTNER, M.D.Search for more papers by this author, JACK H. DEAN, Ph.D.Search for more papers by this author, JOSEPH F. FRAUMENI Jr., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-6-943 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1969 we reported an aggregation of chronic lymphocytic leukemia in three siblings, together with immune defects that may have contributed to the familial predisposition (1). This follow-up study extends the range of B-cell neoplasms and immune defects occurring in this family (Figure 1).In 1974, the 42-year-old daughter (III-2) of the proband developed stage III-A, nodular, poorly differentiated lymphocytic lymphoma, which responded to cyclophosphamide, vincristine, and prednisone. She relapsed in June 1978 and responded to a second course of the same drugs. As a child, numerous vaccinations were unsuccessful; but subsequently, she showed no unusual susceptibility to infection.The...References1. FRAUMENIVOGELDEVITA JCV: Familial chronic lymphocytic leukemia. Ann Intern Med 71:279-284, 1969 LinkGoogle Scholar2. DEANCONNORHERBERMANSILVAMCCOYOLDHAM JRRJJR: The relative proliferation index as a more sensitive parameter for evaluating lymphoproliferative responses of cancer patients to mitogens and alloantigens. Int J Cancer 20:359-370, 1977 CrossrefMedlineGoogle Scholar3. GATTI R: Role of immunological factors in cancer susceptibility, in Genetics of Human Cancer, edited by MULVIHILL JJ, MILLER RW, FRAUMENI JF. New York, Raven Press, 1977, pp. 329-338 Google Scholar4. GUNZVEALE FA: Leukemia in close relatives—accident or predisposition? J Natl Cancer Inst 42:517-524, 1969 MedlineGoogle Scholar5. BLATTNERSTROBERMUCHMOREBLAESEBRODERFRAUMENI WWARSJ: Familial chronic lymphocytic leukemia. Immunologic and cellular characterization. Ann Intern Med 84:554-557, 1976 LinkGoogle Scholar6. BRAYLANJAFFEBERARD REC: Malignant lymphomas: current classification and new observations, in Pathology Annual 1975, edited by SOMMERS SC. New York, Appleton-Century-Crofts, 1975, pp. 213-270 Google Scholar7. RIGBYROSENLOFPRATTLEMON PRPH: Leukemia and lymphoma. JAMA 197:95-100, 1966 CrossrefGoogle Scholar8. FRAUMENIWERTELECKIBLATTNERJENSENLEVENTHAL JWWRB: Varied manifestations of a familial lymphoproliferative disorder. Am J Med 59:145-151, 1975 CrossrefMedlineGoogle Scholar9. POTOLSKYHEATHBUCKLEYROWLANDS ACCD: Lymphoreticular malignancies and immunologic abnormalities in a sibship. Am J Med 50:42-48, 1971 CrossrefMedlineGoogle Scholar10. TILLJONESPENTYCROSSHARDISTYLAWLERHARVEYSOOTHILL MLCRSBJ: Leukaemia in children and their grandparents: studies of immune function in six families. Br J Haematol 29:575-586, 1975 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: National Cancer Institute National Institutes of Health Bethesda Litton Bionetics, Inc. Kensington, Maryland PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByInherited Predisposition to Chronic Lymphocytic LeukemiaGenetic susceptibility to chronic lymphocytic leukemiaFamilial chronic lymphocytic leukaemia: a survey and review of published studiesChronic Lymphocytic LeukemiaChronic lymphocytic leukemia: Present statusUnstable triplet repeat sequences: A source of cancer mutations?Familial cancers associated with subtypes of leukemia and non-hodgkin's lymphomaFamilial cancer syndromes and clustersClinical and laboratory observations in a lymphoma-prone familyFamilial malignant blood disease in the county of Jämtland, SwedenFamilial aggregation of melanoma, basal cell carcinoma, and gastric adenocarcinomaGenetic Epidemiology of Familial Aggregation of CancerIs cancer communicable?Acute and Chronic Lymphocytic LeukemiaMendelian Predisposition to LymphomagenesisGenetic linkage analysis in a high-risk cancer family: HLA and 24 other markersRadiogenic Male Breast Cancer with in Vitro Sensitivity to Ionizing Radiation and BleomycinHairy cell leukemia in father and son 1 June 1979Volume 90, Issue 6Page: 943-944KeywordsB cellsChronic lymphocytic leukemiaClinical laboratoriesCyclophosphamideDrugsLymphomaPediatric infectionsResearch laboratories Issue Published: 1 June 1979 PDF DownloadLoading ...