tbuckley/cabot-search huggingface dataset:
Use of hexobendine to examine whether the coronary vasodilator metabolite released from guinea-pig isolated hearts is adenosine
Authors: A. L ROTHAUL, K. J BROADLEY
Journal: Cardiovascular Research (1981)

Journal Article Use of hexobendine to examine whether the coronary vasodilator metabolite released from guinea-pig isolated hearts is adenosine Get access ALAN L ROTHAUL, ALAN L ROTHAUL From the Department of Applied Pharmacology, Welsh School of Pharmacy, University of Wales Institute of Science and Technology, Cardiff Search for other works by this author on: Oxford Academic PubMed Google Scholar KENNETH J BROADLEY KENNETH J BROADLEY * From the Department of Applied Pharmacology, Welsh School of Pharmacy, University of Wales Institute of Science and Technology, Cardiff *Address for correspondence: Dr K J Broadley, Department of Applied Pharmacology, Welsh School of Pharmacy, University of Wales Institute of Science and Technology, King Edward VII Avenue, Cardiff CFI 3NU, UK. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 15, Issue 10, October 1981, Pages 599–610, https://doi.org/10.1093/cvr/15.10.599 Published: 01 October 1981
HIV viral sequences in seronegative people at risk detected by in situ hybridisation and polymerase chain reaction.
Authors: M. Pezzella, P. Rossi, V. Lombardi, V. Gemelli, R. Mariani Costantini, M. Mirolo, C. Fundaro, V. Moschese, H. Wigzell
Journal: BMJ (1989)

A study was conducted to assess the occurrence of latent infection with the human immunodeficiency virus (HIV) among seronegative people at high risk of infection. The presence of HIV genomes was analysed by molecular techniques in two seronegative children born to mothers infected with HIV and in three regular sexual partners of seropositive drug addicts. The adults were selected from a seronegative cohort at high risk of infection because of their sexual contacts and the children selected because of impaired growth. HIV retroviral sequences were detected in four of the five subjects directly at the cellular level by in situ hybridisation in peripheral blood mononuclear cells. HIV genomic sequences were confirmed by in vitro amplification of viral DNA with the polymerase chain reaction technique. The existence of a latent viral infection state in these seronegative subjects indicates the unreliability of standard serological analysis in people who have been in regular contact with infected patients.
Expression of the T-helper 2-specific chemokine receptor CCR4 on CCR10-positive lymphocytes in atopic dermatitis skin but not in psoriasis skin
Authors: C. Vestergaard, M. Deleuran, B. Gesser, C. Gronhoj Larsen
Journal: British Journal of Dermatology (2003)

Journal Article Expression of the T‐helper 2‐specific chemokine receptor CCR4 on CCR10‐positive lymphocytes in atopic dermatitis skin but not in psoriasis skin Get access C. Vestergaard, C. Vestergaard Department of Dermatology, Marselisborg Hospital, University of Aarhus, PP. Oerumsgade 11, DK‐8000 Aarhus C, Denmark Christian Vestergaard. E‐mail: chr‐vest@post9.tele.dk Search for other works by this author on: Oxford Academic Google Scholar M. Deleuran, M. Deleuran Department of Dermatology, Marselisborg Hospital, University of Aarhus, PP. Oerumsgade 11, DK‐8000 Aarhus C, Denmark Search for other works by this author on: Oxford Academic Google Scholar B. Gesser, B. Gesser Department of Dermatology, Marselisborg Hospital, University of Aarhus, PP. Oerumsgade 11, DK‐8000 Aarhus C, Denmark Search for other works by this author on: Oxford Academic Google Scholar C. Grønhøj Larsen C. Grønhøj Larsen Department of Dermatology, Marselisborg Hospital, University of Aarhus, PP. Oerumsgade 11, DK‐8000 Aarhus C, Denmark Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 149, Issue 3, 1 September 2003, Pages 457–463, https://doi.org/10.1046/j.1365-2133.2003.05505.x Published: 01 September 2003 Article history Accepted: 09 March 2003 Published: 01 September 2003
New Activity on Lung Surfactant
Authors: Ralph A. Redding, Charles T. Hauck, Joseph M. Steim, Myron Stein
Journal: New England Journal of Medicine (1969)

The importance of surface tension at the alveolar interface was demonstrated in 1929,1 and lung extracts capable of markedly lowering surface tension were described by Pattle2 in 1955. Although in the intervening years there has been widespread interest in lung surfactant and over 300 publications have appeared, several basic problems remain. The alveolar lining layer has been difficult to demonstrate anatomically, the chemical identity and quantity of surfactant in man is still unknown, and the physical properties are not well understood. Deficiency or inactivation of lung surfactant has been implicated as part of the pathophysiology of many diseases, but the . . .
ADHERENCE TO MEDITERRANEAN IS THE MOST IMPORTANT PROTECTOR AGAINST THE DEVELOPMENT OF FATAL AND NON-FATAL CARDIOVASCULAR EVENT: 10-YEAR FOLLOW-UP (2002-12) OF THE ATTICA STUDY
Authors: Ekavi N. Georgousopoulou, Christos Pitsavos, Demosthenes Panagiotakos, Christine Chrysohoou, Ioannis Skoumas, Michail Chatzigeorgiou, Christodoulos I Stefanadis
Journal: Journal of the American College of Cardiology (2015)
Can Clinically Significant Prostate Cancer Be Detected with Multiparametric Magnetic Resonance Imaging? A Systematic Review of the Literature
Authors: Jurgen J. Fütterer, Alberto Briganti, Pieter De Visschere, Mark Emberton, Gianluca Giannarini, Alex Kirkham, Samir S. Taneja, Harriet Thoeny, Geert Villeirs, Arnauld Villers
Journal: European Urology (2015)
Variability of house-dust-mite allergen levels within carpets
Authors: A. Simpson, R. Hassall, A. Custovic, A. Woodcock
Journal: Allergy (1998)

Sensitization and exposure to house‐dust‐mite allergens is an important cause of asthma. Standardized, reliable, and reproducible methods for measuring exposure are essential for the assessment of the relationship between exposure, sensitization, and asthma. This study investigated the variability of the house‐dust‐mite allergen Der p 1 concentration in reservoir dust collected within whole carpets in living rooms and bedrooms. The carpets of nine bedrooms and 11 living rooms were sampled. Each room was divided into 1 m 2 areas measured from wall to wall where the carpet was accessible. Reservoir dust samples were collected by vacuuming each 1 m 2 area for 2 min. Der p 1 was assayed by a two‐site monoclonal‐antibody‐based immunometric ELISA. Der p 1 was detectable in the carpets of nine bedrooms and six of the 11 living rooms. Within these 15 rooms, there was a wide range of Der p 1 levels. The smallest range of allergen within single room was 0.9 μg Der p 1/g dust (0.2 and 1.1 ng/g; 5.5‐fold difference), and the largest was 149.2 μg Der p 1/g dust (0.8 and 150 μg/g; 192‐fold difference). The mean range of allergen levels in the living rooms was 11.5 jig Der p 1/g of dust, and the mean coefficient of variation of these rooms was 80.2%. illustrating the huge variation of mite allergen levels within each room. The variation within bedrooms was also large, with a mean coefficient of variation value of 88.7%. The coefficient of variation was significantly lower around soft furnishings or beds (57%) than in the rest the room (89.3%), with the mean difference being 32% (95% CI 27ndash;63%; P=0.04). In conclusion, this study has shown that there is a great variation of Der p 1 levels between areas within a room. No consistent pattern of distribution of mite allergen within a room was found. Der p 1 levels in areas around soft furnishings and beds varied less than the levels in the rest of room.
Haemostatic Changes during Dialysis Associated with Thrombus Formation on Dialysis Membranes
Authors: R. M. Lindsay, C. R. M. Prentice, J. F. Davidson, J. A. Burton, G. P. McNicol
Journal: BMJ (1972)

Platelet counts, coagulation factors, and the fibrinolytic system were studied in seven regular dialysis patients during the course of haemodialysis by parallel flow (Gambro-Alwall) and coil (Travenol Ultra-Flo 100) dialysers. Significant falls in the patients' platelet counts and rises in their factor V levels were found with both dialysis systems. The changes were more pronounced over the course of a Gambro-Alwall dialysis, when significant falls in the partial thromboplastin clotting time and in the plasminogen levels were also noted. These haemostatic changes were associated with the retention of platelets on the dialysis membranes and, in the case of the Gambro-Alwall dialyser, with the formation of platelet-fibrin thrombus. This thrombus formation may take place in spite of efficient heparin anticoagulation and may cause excessive blood loss to the regular dialysis patient.
High direct healthcare costs of patients hospitalised with pandemic (H1N1) 2009 influenza in Malaysia
Authors: Mei Poh Ong, I.-Ching Sam, Haris Azwa, Izam Ezri Mohd Zakaria, Adeeba Kamarulzaman, Mun Hoe Wong, Sharifah Faridah Syed Omar, Samsinah Haji Hussain
Journal: Journal of Infection (2010)
HUNGER PAIN AND DUODENAL ULCER
Authors: B. G. A. Moynihan
Journal: BMJ (1909)

<h3>Abstract</h3> The COVID-19 pandemic raises the need for diverse diagnostic approaches to rapidly detect different stages of viral infection. The flexible and quantitative nature of single-molecule imaging technology renders it optimal for development of new diagnostic tools. Here we present a proof-of-concept for a single-molecule based, enzyme-free assay for detection of SARS-CoV-2. The unified platform we developed allows direct detection of the viral genetic material from patients’ samples, as well as their immune response consisting of IgG and IgM antibodies. Thus, it establishes a platform for diagnostics of COVID-19, which could also be adjusted to diagnose additional pathogens.
Who determines the value of drug-taking behavior? Cultural considerations for a theory of behavioral choice
Authors: Riley E. Hinson
Journal: Behavioral and Brain Sciences (1996)

Abstract Heyman's analysis of addiction suggests that drug taking is irrational. The irrationality of drug taking, however, may depend on the acceptance of mainstream society's view of what is valuable. Consideration of the addict's viewpoint and cultural aspects of drug taking may be useful in trying to fathom the “rationality” of drug taking.
A Novel Mechanism of EML4-ALK Rearrangement Mediated by Chromothripsis in a Patient-Derived Cell Line
Authors: Tatsushi Kodama, Noriko Motoi, Hironori Ninomiya, Hiroshi Sakamoto, Kunio Kitada, Toshiyuki Tsukaguchi, Yasuko Satoh, Kimie Nomura, Hiroko Nagano, Nobuya Ishii, Yasuhito Terui, Kiyohiko Hatake, Yuichi Ishikawa
Journal: Journal of Thoracic Oncology (2014)
Protein synthesis during systolic and diastolic cardiac overloading in rats: a comparative study
Authors: J. M. MOAEIC, J. BERCOVICI, B. SWYNGHEDAUW
Journal: Cardiovascular Research (1981)

Journal Article Protein synthesis during systolic and diastolic cardiac overloading in rats: a comparative study Get access JEAN MARIE MOAEIC, JEAN MARIE MOAEIC From UI27 - INSERM Hôpital Lariboisièrc, F(l) 75010 Paris Search for other works by this author on: Oxford Academic PubMed Google Scholar JOSIANE BERCOVICI, JOSIANE BERCOVICI From UI27 - INSERM Hôpital Lariboisièrc, F(l) 75010 Paris Search for other works by this author on: Oxford Academic PubMed Google Scholar BERNARD SWYNGHEDAUW BERNARD SWYNGHEDAUW * From UI27 - INSERM Hôpital Lariboisièrc, F(l) 75010 Paris *Address for correspondence: Dr H Swynghedauw, U127-INSERM Hôpital Lariboisiére, 41, Boulevard de la Chapelle, 75010 Paris, France. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 15, Issue 9, September 1981, Pages 515–521, https://doi.org/10.1093/cvr/15.9.515 Published: 01 September 1981
Effects on the right ventricle, pulmonary vasculature, and carotid bodies of the rat of exposure to, and recovery from, simulated high altitude
Authors: D. Heath, C. Edwards, M. Winson, P. Smith
Journal: Thorax (1973)

Three groups of 10 adult male Wistar albino rats were studied. The first was kept for five weeks in a hypobaric chamber exposed to a barometric pressure of 380 mmHg, equivalent to a simulated altitude of 5,500 m above sea level. The second was exposed to the same barometric pressure for five weeks and then allowed to recover in room air for a further period of five weeks. The third group acted as controls and was kept at normal barometric pressure throughout. At necropsy right ventricular weight was expressed as an inverse ratio of left ventricular weight (LV/RV ratio). The thickness of the media of the pulmonary trunk was expressed as a ratio of that of the aorta. The volumes of the carotid bodies were measured by applying Simpson9s rule to histological sections. In the first group, exposed to chronic hypoxia without relief, there was hypertrophy of the right ventricle and media of the pulmonary trunk and there was an increase of carotid body volume, as compared with the values obtained in the controls. In the recovery group these three measurements had returned almost to normal. The results appear to be applicable to hypoxic cor pulmonale in man. They suggest that hypoxia rapidly produces pulmonary hypertension and its morbid anatomical associations while recovery is equally rapid once the hypoxic stimulus is removed.
Urodilatin limits acute reperfusion injury in the isolated rat heart
Authors: J Inserte
Journal: Cardiovascular Research (2000)

Hypercontracture is an important mechanism of myocyte death during reperfusion. cGMP modulates the sensitivity of contractile myofilaments to Ca2+, and increasing cGMP concentration during the last minutes of anoxia prevents reoxygenation-induced hypercontracture in isolated cardiomyocytes. The purpose of this study was to determine whether stimulation of particulate guanylyl cyclase with the natriuretic peptide urodilatin, given at the time of reperfusion, reduces myocardial necrosis in the rat heart submitted to transient ischemia.Isolated rat hearts (n = 38) were submitted to either 40 or 60 min of no-flow ischemia and 2 h of reperfusion, and were allocated to receive or not receive 0.05 microM urodilatin during the first 15 min of reperfusion or non-reperfusion treatment.A marked reduction in myocardial cGMP concentration was observed in control hearts during reperfusion after 40 or 60 min of ischemia. Urodilatin significantly attenuated cGMP depletion during initial reperfusion, markedly improved contractile recovery after 40 min of ischemia (P < 0.0309), and reduced reperfusion-induced increase in left ventricular end-diastolic pressure (P = 0.0139), LDH release (P = 0.0263), and contraction band necrosis (P = 0.0179) after 60 min of ischemia. The beneficial effect of urodilatin was reproduced by the membrane permeable cGMP analog 8-Bromo-cGMP.These results indicate that reduced cGMP concentration may impair myocyte survival during reperfusion. Stimulation of particulate guanylyl cyclase may appear as a new strategy to prevent immediate lethal reperfusion injury.
Unhygienic circumcisions may increase risk of HIV transmission
Authors: Peter Moszynski
Journal: BMJ (2007)

Lester Crawford, former commissioner of the US Food and Drug Administration, was last week fined $89 377 (£45 800; €67 000), sentenced to three years of supervised probation, and required to do 50 hours of community service by Judge Deborah Robinson of the US District Court for the District of Columbia.Last October Dr Crawford (below) pleaded (below) pleaded pleaded guilty to two charges: failing to report that he and his wife owned shares in companies regulated by the agency and filing false
Radioisotope techniques. Intracavitary placement of radium, interstitial implantations, instillations
Authors: M. Friedman
Journal: JAMA (1968)

Radiation therapy of any tumor, and particularly bladder cancer, is best accomplished whenever possible by an interior radiation technique, ie, a single radium capsule placed in the center of a 30-cc Foley balloon (the Walter Reed technique), or by inserting radium needles or radioactive tantalum (<sup>182</sup>Ta) wire sources into the tumor. These produce higher cure rates than external irradiation, while minimizing irradiation of adjacent normal tissues. Despite the superior results of these interior techniques,<sup>13-16</sup>they are used in few clinics. Their unpopularity is probably due to the complexity of the techniques and the considerable time and effort required of the radiotherapist-urologist team to executive them. The most commonly employed program for treating papilloma and low-grade papillary carcinoma consists of repeated transurethral resections followed by external irradiation when the neoplasm becomes aggressive. Its popularity, despite the relatively poor results, is probably due to its relative simplicity. It is unfortunate
Making Miracles: In Vitro Fertilization
Authors: Nancy Jo Zaffaro
Journal: JAMA (1986)

Nan and Todd Tilton are a persistent couple. They fortunately have a strong relationship within a supportive family background. Their expectation of a family is never questioned as they attempt to conceive after two years of marriage. After four months of unsuccessful attempts, Nan starts wondering whether there is something wrong with her. Like an estimated 3.5 million American couples, the Tiltons had a fertility problem. The authors' account of their initial visit to an infertility specialist clearly reflects infertile couples' early misconceptions surrounding infertility. The Tiltons expect immediate diagnosis and a quick remedy for their problem. Instead, they are presented with a long list of diagnostic tests. We sympathize with their shock. It will take months to go through the tests. The couple later regret their quick retreat from investigation, but their apprehension at the time is understandable. This begins the couple's five-year struggle to treat their combined infertility
Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells
Authors: Marc Veldhoen, Keiji Hirota, Jillian Christensen, Anne O'Garra, Brigitta Stockinger
Journal: The Journal of Experimental Medicine (2008)

Th17 cell differentiation is dependent on interleukin (IL)-6 and transforming growth factor (TGF)-β, and it is modulated by activation of the aryl hydrocarbon receptor (AhR). In this study, we show that differentiation of Th17 cells, but not Th1 or induced regulatory T (iT reg) cells, is increased by endogenous AhR agonists present in culture medium. Th17 development from wild-type mice is suboptimal in the presence of the AhR antagonist CH-223191, similar to the situation in AhR-deficient mice, which show attenuated IL-17 production and no IL-22 production. The presence of natural AhR agonists in culture medium is also revealed by the induction of CYP1A1, a downstream target of AhR activation. However, the most commonly used medium, RPMI, supports very low levels of Th17 polarization, whereas Iscove's modified Dulbecco's medium, a medium richer in aromatic amino acids, which give rise to AhR agonists, consistently results in higher Th17 expansion in both mouse and human cells. The relative paucity of AhR agonists in RPMI medium, coupled with the presence of factors conducive to IL-2 activation and enhanced Stat5 phosphorylation, conspire against optimal Th17 differentiation. Our data emphasize that AhR activation plays an essential part in the development of Th17 cells and provide a rational explanation for the poor in vitro polarization of Th17 cells that is reported in the majority of publications for both mouse and human cells.
High Serum Iron Is Associated with Increased Cancer Risk
Authors: Chi Pang Wen, June Han Lee, Ya-Ping Tai, Christopher Wen, Shiuan Be Wu, Min Kuang Tsai, Dennis P.H. Hsieh, Hung-Che Chiang, Chao Agnes Hsiung, Chung Y. Hsu, Xifeng Wu
Journal: Cancer Research (2014)

Epidemiologic studies linking high serum iron with cancer risks are limited and inconclusive, despite evidence implicating body iron in human carcinogenesis. A cohort of 309,443 adults in Taiwan who had no history of cancer had serum iron levels tested at the time of recruitment (1997-2008). Initially measured iron levels were associated with subsequent cancer risk by linking individuals with the National Cancer Registry and National Death File. HRs were calculated by the Cox model. One third of males (35%) and one fifth of females (18%) had high serum iron (≥120 μg/dL), which was associated with a 25% increase in risk for incidence of all cancers [HR, 1.25; 95% confidence interval (CI), 1.16-1.35] and with a 39% increase in risk for mortality from all cancers (HR, 1.39; 95% CI, 1.23-1.57). The relationship between serum iron and cancer risk was a J-shaped one, with higher cancer risk at both ends, either at lower than 60 μg/dL or higher than 120 μg/dL. At the higher end, cancer risk increased by 4% for every 10 μg/dL increment above 80 μg/dL, showing a dose-response relationship, with 60 to 79 μg/dL as a reference level. In a sensitivity analysis, the increases in risk were still observed after the first 5 years of cancer cases were excluded. Liver cancer risk was increased in HBV (-) non-hepatitis B carrier (3-fold) and HBV (+) hepatitis B carrier (24-fold). Lifestyle risks such as smoking, drinking, or inactivity interacted synergistically with high serum iron and significantly increased the cancer risks. The liver (HR, 2.49; 95% CI, 1.97-3.16) and the breast (HR, 1.31; 95% CI, 1.01-1.70) were the two major cancer sites where significant cancer risks were observed for serum iron either ≥120 μg/dL or ≥140 μg/dL, respectively. This study reveals that high serum iron is both a common disorder and a marker of increased risk for several cancers.
Vitamin C and Chemotherapy
Authors: Carolyn J. Hildreth
Journal: JAMA (2008)

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