tbuckley/cabot-search huggingface dataset:
Measuring Blood Pressure for Decision Making and Quality Reporting
Authors: Omega C. Logan Silva
Journal: Annals of Internal Medicine (2011)

Letters18 October 2011Measuring Blood Pressure for Decision Making and Quality ReportingOmega C. Logan Silva, MDOmega C. Logan Silva, MDFrom George Washington University, Washington, DC 20052.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-155-8-201110180-00025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I read with great interest the article by Powers and colleagues (1). I agreed with most of the article, but I wondered why the authors did not discuss the proper technique of taking blood pressure. Maybe what I was taught is out of date, but is not the position of the arm, the level of the arm in relation to the heart, and the size of the cuff important to obtaining an accurate reading?Omega C. Logan Silva, MDGeorge Washington UniversityWashington, DC 20052Reference1. Powers BJ, Olsen MK, Smith VA, Woolson RF, Bosworth HB, Oddone EZ. Measuring blood pressure for decision making and quality reporting: where and how many measures? Ann Intern Med. 2011;154:781-8, W-289-90. [PMID: 21690592] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From George Washington University, Washington, DC 20052.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoMeasuring Blood Pressure for Decision Making and Quality Reporting: Where and How Many Measures? Benjamin J. Powers , Maren K. Olsen , Valerie A. Smith , Robert F. Woolson , Hayden B. Bosworth , and Eugene Z. Oddone Measuring Blood Pressure for Decision Making and Quality Reporting Randy Wexler Measuring Blood Pressure for Decision Making and Quality Reporting Benjamin J. Powers , Eugene Z. Oddone , and Hayden B. Bosworth Metrics 18 October 2011Volume 155, Issue 8Page: 565KeywordsBlood pressureConflicts of interestDecision makingHeart ePublished: 18 October 2011 Issue Published: 18 October 2011 Copyright & PermissionsCopyright © 2011 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Raised Serum IgG Levels in Hypertension
Authors: A. Ebringer, A. E. Doyle
Journal: BMJ (1970)

Serum IgG levels were significantly higher in 118 severely hypertensive patients compared with a group of 163 normotensive blood donors, matched for age and sex. Serum IgA and IgM were the same in both groups. Raised levels of serum IgG were found in patients who had never been treated for hypertension, as well as in those who were treated with methyldopa or other hypotensive drugs.It is suggested that the raised levels of serum IgG may be an index of vascular damage induced by hypertension.
My Son's Ears
Authors: David L. Schiedermayer
Journal: JAMA (1986)

My son's ears are infected again, the ENT doctor explains. He has had a dozen infections, and his ears are showing the strain—a mild hearing loss. Needs surgery, little tubes, the physician says once more. I look up, bewildered at the word. Surgery is for patients. Surgery is for an objective body beneath sterile drapes, an acquaintance who needs repair. Surgery is not for my son, my boy with the wheat blond hair who claims to be big at all times, who wears diapers beneath bravado He-man underwear, who eats popsicles in the bathtub with the gusto of a cowboy drinking gin. Surgery is not for him. Thursday the ninth at Children's Hospital, the otolaryngologist is saying—only 20 minutes, a few puffs of anesthesia, goes home same day. So now we are patients, already feeling the odd powerlessness. We had a party scheduled that day, but how can you refuse
Central Auditory Imperception
Authors: Mary D. Ames
Journal: JAMA (1970)

Central auditory imperception was found as the only cause for the failure of 30 of 118 children with congenital rubella to respond to sound. An additional 20 children were found to have central auditory imperception in association with peripheral hearing loss and blindness.<sup>1</sup>Since the presenting problem was failure to develop speech, central auditory imperception, peripheral hearing impairment, and mental retardation had to be considered in the differential diagnosis. Audiometry and psychological testing were used to separate these deficits. The type of education required varies with the diagnosis.
Minister backs social enterprise model in healthcare market
Authors: Andrew Cole
Journal: BMJ (2007)

Social enterprises—businesses for which the bulk of profits are reinvested in the community—will be one of the keys to transforming health and social care in the next decade, claims the health secretary, Patricia Hewitt.

Ms Hewitt was speaking at the launch of Healthy Business , a publication from the Social Enterprise Coalition, which describes nine social enterprises already operating successfully in health care. They include an out of hours GP service, a nurse run general practice, and a community led primary care centre.

The government has put increasing weight behind encouraging new providers into the health market. Last year's Our Health, …
Prednisolone and Mustine in Prevention of Tumour Swelling during Pulmonary Irradiation
Authors: S. J. Cameron, I. W. B. Grant, J. G. Pearson, C. Marques
Journal: BMJ (1972)

Ventilatory function declines during the early stages of irradiation for bronchial carcinoma. This decline is potentially dangerous if the tumour narrows the trachea or both main bronchi. The protective effect of preliminary treatment with prednisolone or mustine before irradiation was studied in 88 patients by serial estimations of forced expiratory volume and forced vital capacity. Twenty-three patients received prednisolone by mouth, 24 had mustine intravenously, and 41 had no preliminary treatment. Both prednisolone and mustine prevented a significant decline in ventilatory function due to tumour swelling, prednisolone being marginally superior. It is concluded that all patients at risk should be treated with oral prednisolone, 20 mg daily, for one day before and two days after the first fraction of irradiation.
A Case of Tetanus treated by Injections of Carbolic Acid
Authors: P. Stewart, J. T. C. Laing
Journal: BMJ (1914)

TETANUS TREATED BY INJECTIONS OF CARBOLIC ACID.[DEc. 26, zgz4 were collected only from the larder or passages adjacent to the kitcllenis; in no case were they taken from lavatories or from state-roolus.The general condition of the ship, rvlhich was almost new, was one of exceptional cleanliness, and thus afforded good conditions for the experiments.Dr. Morrell was of opiillon that tllere was little danger except by cointamination fromi-the faeces of the infected insect.Olne of hiis first experiments was to prove that should cock- roaches fall inito tlle dough which was being baked for bread the hleat of the baking entirely destroyed the bacilli that were in the alimentary canal of the insect.With regard to infectioni with the colon bacillus he kept an infected insect under the best antiseptic conditions lhe could compass until it had passed somne undigested food.Of this un- diaested food an emnlsion was prepared, and cultures were imiade fromn it on bile-salt mediuLm and in litmus-milk.Afterwards special cultures were made in gelatine and peptonc solutiolns.Inicubation was conducted in all cases
Cuboidal calcium enterolith causing obstruction and perforation of small intestine.
Authors: J Walker, I O Ellis
Journal: BMJ (1984)

fresh lesions were seen, and his general condition and the lesions improved rapidly.Case 2-A 12 year old European boy was admitted with fever, considerable herpetiform eruption on his face and neck, and severe angio-oedema of periorbital tissues (figure).The eruption had begun four to five days previously and had spread explosively.He had a history of atopic eczema from infancy, but there had been good spontaneous improvement over the past year or two.No pyogenic organisms were isolated from repeated blood cultures and multiple skin swabs.Virus culture confirmed a diagnosis of herpes simplex infection.The vesicles continued to spread and disseminate, and he was given oral acyclovir 200 mg every four hours five times daily for five days.This dosage was equivalent to 25 mg/kg body weight/day.No further eruption of herpetic lesions occurred (figure), and no evidence of herpetic infection was detected in his eyes.He was also treated with flucloxacillin and sodium fusidate ointment to prevent secondary bacterial infection.'-Zeit RM.Enterolithiasis associated with ileal perforation in Crohn's disease.
The acute promyelocytic leukemia–associated protein, promyelocytic leukemia zinc finger, regulates 1,25-dihydroxyvitamin D3–induced monocytic differentiation of U937 cells through a physical interaction with vitamin D3receptor
Authors: Jeremy O. Ward, Melanie J. McConnell, Graeme W. Carlile, Pier Paolo Pandolfi, Jonathan D. Licht, Leonard P. Freedman
Journal: Blood (2001)
INTESTINAL AND MESENTERIC INJURY DUE TO NONPENETRATING ABDOMINAL TRAUMA
Authors: D. HENRY POER
Journal: JAMA (1942)

Our purpose in this communication is to set forth the results of studies of a surgical problem for which treatment up to now has been significantly unsuccessful, as evidenced by a distressingly high mortality rate. These studies regard the little-understood injuries to the intestine and the mesentery by force which does not penetrate the abdominal parietes, and they were occasioned by recent clinical experiences in which the unfortunate outcome, while expected and reasonably explained, yet seemed preventable. During the past year we have observed 3 patients with rupture of the intestine, in 1 of whom the diagnosis was obvious and prompt operative treatment was followed by recovery. Operation on the other 2 patients was delayed until after the full development of generalized peritonitis, with resulting death. With full realization that recovery might have been possible had the diagnosis been made in the first few hours after injury and with a
TEST FOR INCOMPETENT COMMUNICATING BRANCHES IN THE SURGICAL TREATMENT OF VARICOSE VEINS
Authors: Gerald H. Pratt
Journal: JAMA (1941)

Before one decides which type of treatment the patient who has varicose veins is to undergo, certain tests must be performed. These are:  1. Test for the adequacy of the arterial circulation: The history of arterial competence, freedom from rubor on dependence or pallor on elevation, the palpation of the dorsalis pedis and posterior tibial arteries and the oscillometric readings.  2. Tests for the adequate functioning of the deep venous circulation (modified Perthes test): The leg is elevated and the veins are emptied. A tourniquet is applied to the upper thigh to constrict the saphenous vein return flow. The patient then walks around the room for five minutes. Absence of pain in the calf or definite swelling of the foot and ankle indicates patent deep veins.  3. Test for competence of the saphenous femoral valve (modified Trendelenburg test): The leg is elevated and the veins are emptied. The tourniquet is
Allogeneic virus-specific T cells with HLA alloreactivity do not produce GVHD in human subjects
Authors: J. Joseph Melenhorst, Ann M. Leen, Catherine M. Bollard, Máire F. Quigley, David A. Price, Cliona M. Rooney, Malcolm K. Brenner, A. John Barrett, Helen E. Heslop
Journal: Blood (2010)
Absorption of Salicylic Acid
Authors: Peter A. Soyka
Journal: JAMA (1980)

<h3>To the Editor.—</h3> For the past several years a keratolytic gel developed by Baden<sup>1</sup>has been used as a treatment for hyperkeratotic disorders of the skin. The gel consists of 20% ethanol, 20% water, and 6% salicylic acid in propylene glycol and is marketed under the brand name Keralyt. Treatment involves application of the gel to the affected areas after hydration of the skin. The epidermal surface being treated is then occluded under a plastic dressing overnight. In many cases considerable clearing of hyperkeratotic lesions has been achieved through the use of this regimen. Baden's studies indicated that salicylism does not occur to any great extent because of the use of this preparation.<sup>1</sup>Another study using the keratolytic gel supported this assertion.<sup>2</sup> However, salicylic acid can and does penetrate the epidermis after topical administration; this fact has been recognized for nearly a century.<sup>3</sup>The literature contains
Bursectomy in Gastric Cancer Surgery I.B. Shchepotin O.O. Kolesnik, A.V. Lukashenko, A.A. Burlaka, M.O. Volk, Y.O. Zhukov Department of Abdominal Surgery, National Cancer Institute, Kyiv, Ukraine
Authors: Shchepotin Ighor, Kolesnik Olena, Lukashenko Andrii, Burlaka Anton, Volk Maryna, Zhukov Yuriy
Journal: Annals of Oncology (2014)
ERISA Ruling Creates Options for State Reforms
Authors: Rebecca Voelker
Journal: JAMA (1995)

FOR SEVERAL years, states interested in expanding access to health care and finding ways to finance it frequently invoked the equivalent of a five-letter swearword: ERISA. Because it broadly preempts state laws that "relate to" employee benefit plans, including health insurance, the Employee Retirement Income Security Act of 1974 is considered a leading obstacle to health system reform at the state level (<i>JAMA</i>. 1995;273:187-188). Only one state—Hawaii—is exempt because its universal coverage program was enacted shortly before Congress approved ERISA. The remainder haven't been able to extract from Congress ERISA waivers that, while aiding states in financing expanded access, might also prove costly to employers. Last April, however, the states got a burst of good news on the ERISA front. In<i>New York State Conference of Blue Cross &amp; Blue Shield Plans v Travelers Insurance Co</i>, the US Supreme Court sanctioned New York's hospital rate-setting program that, in effect, subsidizes
Aneurysm of the Splenic Artery
Authors: John A. Spittel
Journal: JAMA (1961)

This study comprises 15 cases of aneurysm of the splenic artery diagnosed preoperatively and 46 cases investigated at necropsy. Of the 61 subjects, 46 were women. From histologic studies in 38 cases, the most common causative factors proved to be atherosclerosis (22 cases) and congenital causes (11 cases). Typical calcification in roentgenograms of the abdomen was the most common clinical manifestation suggesting the diagnosis in the 15 patients. Only 2 of the 15 had symptoms from their aneurysms. The lesions were discovered during examination for some unrelated problem in the remaining 13 patients; diagnosis was confirmed by aortography.
Ariel's Flight
Authors: N. J. C. Andreasen
Journal: JAMA (1974)

EARLY in the morning, during a London winter so chill that the water pipes had frozen in her flat, a 30-year-old woman took two pitchers of milk and some bread up to her two young children so they would have food in the morning, returned to the stark blue-whiteness of her kitchen, lay down to rest with her head in a gas oven, and died. Sylvia Plath, so intelligent and efficient and sensitive, did everything exceptionally well, including both living and dying. Yet beneath the false bravado she felt "like Hell." Just prior to her death she wrote a small body of poems, published posthumously in the volume<i>Ariel</i>, of astonishing pain and power which has already become a modern classic. They portray aspects of the private world of mental illness that led to her unexpected death. Her suicide was a tragedy in the true—not the popular sentimental—sense, for she
Abstract 5175: Discovering a novel role of claudin-7 as a basolateral protein maintaining cell-matrix interactions in human lung cancer cells and in mouse intestines
Authors: Zhe Lu, Lei Ding, Qun Lu, Yan-Hua Chen
Journal: Cancer Research (2012)

Abstract The ability to invade host tissues and metastasize is the major cause of cancer-related death. During tumor invasion, metastasizing cells disrupt normal cell-matrix adhesion and acquire an invasive phenotype. Claudins are adhesion proteins localized at tight junctions (TJs). Claudin-7 is a unique TJ membrane protein in that it has a stronger basolateral membrane distribution than that of apical TJs in epithelial cells. To study the basolateral function of claudin-7, claudin-7 gene silencing experiments were carried out in a lung cancer cell line using the lentivirus shRNA approach. We found that claudin-7 knockdown (KD) cells showed disrupted cell-matrix interactions. Consequently, when claudin-7 KD cells were plated on the uncoated glass surface, they were unable to attach to the glass and died the day after plating. In contrast, control cells adhered well and grew normally. Using immunofluorescent microscopy and biochemistry methods, we found that claudin-7 co-localized and co-immunoprecipitated with integrin β1 at the basolateral compartment. Knockdown of claudin-7 by lentivirus claudin-7 shRNA downregulated integrin β1 at both mRNA and protein levels. This cell-matrix defect can be rescued by transfecting claudin-7 or integrin β1 back to the claudin-7 KD cells. Suppression of claudin-7 also upregulated matrix metalloproteinase-3 (MMP-3) at both mRNA and protein levels and downregulated several collagens, such as type V α1, type XV α1, and type XVI α1, at the mRNA level. We also generated claudin-7-deficient (Cldn7−/−) mice using targeted-gene deletion method. Cldn7−/− mice displayed severe intestinal defects including attenuated villi, mucosal ulcerations and epithelial cell sloughing. Using immunofluorescent microscopy and biochemistry methods, we found that claudin-7 co-localized and co-immunoprecipitated with integrin α2 in Cldn7+/+ mouse intestines where claudin-7 was highly expressed. Deletion of claudin-7 reduced integrin α2 expression and altered its localization. Electron microscopy revealed significant intercellular gaps below TJs and the cell-matrix loosening in Cldn7−/− intestines. Thus, our current study highlights a novel non-TJ function of claudin-7 in maintaining epithelial cell-matrix interactions by interacting with integrins. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5175. doi:1538-7445.AM2012-5175
INTEGRATED AREA DESATURATION INDEX IS MAJOR PREDICTOR OF FATAL CARDIOVASCULAR EVENTS IN PATIENTS WITH HEART FAILURE AFTER ADAPTIVESERVO VENTILATION THERAPY
Authors: Noriaki Takama, Syuntaro Tamura, Kuniko Masuda, Makoto Murata, Kosaku Goto, Yoshiaki Ohyama, Ryuichi Funada, Norimichi Koitabashi, Masashi Arai, Masahiko Kurabayashi
Journal: Journal of the American College of Cardiology (2013)
Athletic Facial Injuries: Call in Everyone-Reply
Authors: Richard C. Schultz
Journal: JAMA (1985)

<h3>In Reply.—</h3> Several of the respondents criticized the scope of the manuscript. This particular review article could not possibly include all ophthalmologic, otolaryngologic, and neurological injuries. We presented instead a brief overview of common maxillofacial injuries in the athlete. A more comprehensive presentation will be available later this year in a textbook on sports injuries edited by Kenneth DeHaven, MD. In one publication we have combined our efforts with other specialists from otolaryngology, oral surgery, and ophthalmology to give a more comprehensive review of these injuries. The letter by Dr Wesley refers to the controversy surrounding the treatment of orbital floor fractures. Although some authors favor nonoperative management, we prefer early exploration and repair of orbital blowout fractures. This approach reduces the long-term sequelae such as diplopia and enophthalmos and restores the continuity of the orbital floor. Early intervention minimizes the fibrosis and shortening of extraocular muscles and globe-supporting septa
Number of Daytime Micturitions and Volume Voided per Micturition in the Evaluation of Efficacy of Drugs for Overactive Bladder: Findings from Randomized Clinical Trials
Authors: Enrico Colli, Fabio Parazzini, Lorenza Olivieri, Sonia Cipriani, Rosanna Bertozzi, Michele Meschia, Francesco Montorsi
Journal: European Urology (2007)
Nonspecific Vaginitis
Authors: Terrence A. Pheifer, Patricia S. Forsyth, Marcia A. Durfee, Helen M. Pollock, King K. Holmes
Journal: New England Journal of Medicine (1978)

To assess the cause of nonspecific vaginitis, we performed a prospective case-control study of vaginal flora and a randomized unblinded trial of different therapies. Haemophilus vaginalis was isolated from 17 to 18 women with signs of vaginitis but only one of 18 normal matched controls (P less than 0.002). The concentration of anaerobic bacteria in vaginal washings also was increased in patients. Clinical improvement and eradication of H. vaginalis occurred in one of seven patients given sulfonamide vaginal cream, two of 15 given oral doxycycline, nine of 27 given oral ampicillin, and 80 of 81 given oral metronidazole. On the seventh day of therapy signs of nonspecific vaginitis persisted in 31 of 31 with, and in two of 92 without, persistent H. vaginalis infection (P less than 0.001). These data suggest the causal role of H. vaginalis in nonspecific vaginitis, possibly in concert with vaginal anaerobes. The widespread use of sulfonamide creams is inappropriate. Metronidazole is effective, but its efficacy must be weighed against its possible toxicity.