tbuckley/cabot-search huggingface dataset:
Rheumatoid Arthritis in Hyperthyroidism
Authors: HERBERT E. COHEN
Journal: Annals of Internal Medicine (1978)

Letters and Corrections1 August 1978Rheumatoid Arthritis in HyperthyroidismHERBERT E. COHEN, M.D., F.A.C.P.HERBERT E. COHEN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-89-2-290 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The observation that rheumatoid factors may reflect the immune nature of Graves' disease (1) is of interest, but unfortunately the authors did not consider the even more provocative inverse implications of their results on the causality of rheumatoid arthritis. The negative disease interaction between hyperthyroidism and rheumatoid arthritis is not generally appreciated, but clinical rheumatoid arthritis is uncommon in the presence of hyperthyroidism, and treatment of hyperthyroidism occasionally precipitates an acute attack of rheumatoid arthritis. The fact that hyperthyroid suppression of rheumatoid arthritis occurs in the presence of serum titers of rheumatoid factors is unexpected and worthy...Reference1. SILVERBERGVOLPÉ JR: Rheumatoid factors in Graves' disease. Ann Intern Med 88:216-217, 1978 LinkGoogle Scholar1. BASTENIEERMANS PA: Thyroiditis and Thyroid Function. New York, Pergamon Press, 1972 Google Scholar2. KRANEGOLDRING SS: Skeletal system, in The Thyroid, 4th ed., edited by WERNER SC INGBAR SH, New York, Harper and Row, 1978, p. 739 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Presbyterian-University of Pennsylvania Medical Center Philadelphia, PA 19104 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1978Volume 89, Issue 2Page: 290-290KeywordsHyperthyroidismRheumatoid arthritis Issue Published: 1 August 1978 PDF DownloadLoading ...
A Phase I Study of PF-04929113 (SNX-5422), an Orally Bioavailable Heat Shock Protein 90 Inhibitor, in Patients with Refractory Solid Tumor Malignancies and Lymphomas
Authors: Arun Rajan, Ronan J. Kelly, Jane B. Trepel, Yeong Sang Kim, Sylvia V. Alarcon, Shivaani Kummar, Martin Gutierrez, Sonja Crandon, Wadih M. Zein, Lokesh Jain, Baskar Mannargudi, William D. Figg, Brett E. Houk, Michael Shnaidman, Nicoletta Brega, Giuseppe Giaccone
Journal: Clinical Cancer Research (2011)

To determine the maximum tolerated dose (MTD), toxicities, and pharmacokinetic/pharmacodynamic profile of the Hsp90 inhibitor PF-04929113 (SNX-5422) in patients with advanced solid tumors and lymphomas.This was a single-institution, phase I, dose-escalation study of PF-04929113 administered twice weekly. Endpoints included determination of dose-limiting toxicities (DLT), MTD, the safety profile of PF-04929113, pharmacodynamic assessment of PF-04929113 on Hsp70 induction, pharmacokinetic analysis of PF-04928473 (SNX-2112) and its prodrug PF-04929113, and assessment of response.Thirty-three patients with advanced malignancies were treated. Dose escalation was continued up to 177 mg/m(2) administered orally twice a week. One DLT (nonseptic arthritis) was noted. No grade 4 drug-related adverse events were seen; grade 3 adverse events included diarrhea (9%), nonseptic arthritis (3%), aspartate aminotransferase elevation (3%), and thrombocytopenia (3%). No objective responses were seen in 32 evaluable patients. Fifteen patients (47%) had stable disease; 17 patients (53%) had progressive disease. Pharmacokinetic data revealed rapid absorption, hepatic, and extrahepatic clearance, extensive tissue binding, and almost linear pharmacokinetics of the active drug PF-04928473. Pharmacodynamic studies confirmed inhibition of Hsp90 and a linear correlation between pharmacokinetic parameters and Hsp70 induction.PF-04929113 administered orally twice a week is well tolerated and inhibits its intended target Hsp90. No objective responses were seen, but long-lasting stabilizations were obtained. Although no clinically significant drug-related ocular toxicity was seen in this study, the development of PF-04929113 has been discontinued because of ocular toxicity seen in animal models and in a separate phase I study.
Transillumination of the Ventricular Septum
Authors: William F. Bernhard, Robert Innis, Robert E. Gross
Journal: New England Journal of Medicine (1962)

THE majority of ventricular septal defects are solitary in occurrence, involve the infracristal area of the septum and can be diagnosed with consistent accuracy by means of catheterization of the right side of the heart, dye dilution technics and cineangiography.1 , 2 In the absence of severe pulmonary hypertension closure of such defects, by direct suture or insertion of a prosthesis, can be accomplished with little technical difficulty and a low operative mortality.Unfortunately, the management of patients with multiple defects, which occur in approximately 10 per cent of cases, is much less satisfactory. Since the hemodynamic effects of single and multiple . . .
Gene and protein expression profile and prognosis in high-risk primary breast cancer
Authors: G. Somlo, S. Schneider, P. Chu, W. Ye, P. Frankel, C. Ruel, J. H. Doroshow, K. Danenberg, P. Danenberg
Journal: Journal of Clinical Oncology (2004)

9569 Background: We set out to establish prognostic and predictive indicators of outcome in patients (pts) with high-risk primary breast cancer (HRBC), by evaluating pathologic and molecular features of the primary tumors (PT). Methods: RNA was extracted from paraffin-embedded PT for RT-PCR testing for a panel of genes, including EGFR, HER-2, GST-Pi, ERCC1, p21, and Beta tubulin-3. H&E and immunohistochemical stain (IHC) were examined to assess expression of 12 proteins, including p16, p21, p27, HER-2, p53, ER/PR, CD1a, and Ki-67. The analysis was carried out in 240 (52 % of all eligible) pts who were treated on IRB-approved platinum, doxorubicin (Dox) and/or paclitaxel-containing dose-intense chemotherapy (DICT) protocols between 1989 and 2003, at the COHNMC. Results: Pts were treated for stage II ( ≥ 10 lymph nodes with metastasis [LNM]; 41%), IIIA (39%), and IIIB inflammatory BC (20%). The median age was 46 years (26–62), the median no. of LNM was 12 (0–42). Twenty percent of pts received neoadjuvant Dox CT with or withour a taxane. All pts received adjuvant CT with Dox with or without a taxane, followed by DICT. At a median follow-up of 86 months RFS and overall survival (OS) are 50% (95% CI; 43–57%) and 62% (56–69%). In univariate analysis RFS was shorter in pts whose PT were characterized by high-grade, ER/PR receptor negativity, greater expression of p16 by IHC, and low expression of p21 by IHC and by RT-PCR, and increased EGFR expression; OS was similarly effected by the same parameters and by lack of p27 and overexpression of Ki-67 by IHC (p< 0.05). In multivariate Cox stepwise analysis, after adjusting for age and stage, p21 overexpression and ER/PR receptor positivity were associated with improved RFS and OS. The predictive value of expression of other drug-resistance genes for specific DICT-associated survival is under evaluation. Conclusion: A prognostic model combining RT-PCR and IHC detection of markers of cell regulation, proliferation, and resistance may help to define target-specifc therapies in patients with HRBC. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Response Genetics Response Genetics Response Genetics; Bristol-Myers Squibb; Amgen
Move to weaken picture warnings on tobacco packets in India causes outcry
Authors: Ganapati Mudur
Journal: BMJ (2007)

Survival of UK patients after cancer is improving but still lags behind the European average, despite the United Kingdom spending more than other countries on cancer, different sources of data published this week show.Figures from the Office for National Statistics (ONS) show that between 1999 and 2004 survival rates for most cancers in England improved.However, two studies published in Lancet Oncology (
Critical Issues in HMO Strategy
Authors: James A. Vohs, Richard V. Anderson, Ruth Straus
Journal: New England Journal of Medicine (1972)

Abstract Proponents of health-maintenance organizations (HMOs) hope that organized health-care delivery systems will solve problems of cost, manpower scarcity, inaccessibility and uneven quality of medical care. Some current federal legislative activity is intended to support the development of HMOs, but certain of its aspects may have a detrimental effect on such factors as the capability of HMOs to enroll Medicare beneficiaries under the HMO option, the adequacy of levels of reimbursement to HMOs by the Social Security Administration, and the ability of HMOs to provide or arrange for all services covered by Medicare. The legislation proposes quality standards in the absence of satisfactory methods for evaluating the quality of care. Studies are in order to reach a fuller understanding of the provisions under which HMOs will be able to operate successfully.
US needs universal access to health care, American College of Physicians says
Authors: Janice Hopkins Tanne
Journal: BMJ (2007)

The American College of Physicians says that the United States needs a healthcare system that provides care for everyone, either through a universal health insurance system, such as the UK NHS, or through a pluralistic system that involves the government and private organisations.

The college’s three-part position paper was published on its website (www.annals.org). It will appear in the 1 January issue of the Annals of Internal Medicine . The college has 124 000 members and is second only to the American Medical Association in membership.

The college released the report “to provoke a national discussion, during this critical election year, on how to make the US the best performing healthcare system in the world . . . our country’s current pluralistic system without universal …
Acromegaly: Treatment by Cryoablation
Authors: JAMES A. MADDY
Journal: Annals of Internal Medicine (1969)

Results of cryoablation of pituitary adenomas in seven patients with acromegaly are described. Objective and subjective improvement, as well as reduction in human growth hormone (HGH) levels, occurred in each case with a minimum of complications and difficulties. Complete remission was not obtained in two patients, one of whom underwent the procedure on two occasions. Some clinical and biochemical improvement was observed in these patients as well as reduced HGH levels. The five patients who attained normal HGH levels reached this range within 1 month and usually within 5 days, postoperatively. They had satisfactory clinical remissions as well as of the chemical signs of acromegaly. In several instances some or most of normal pituitary function was maintained despite apparent satisfactory destruction of the HGH-secreting tumor. In our experience, cryohypophysectomy is a relatively simple and safe procedure that has proved effective in the treatment of acromegaly.
Stromal gene expression defines poor-prognosis subtypes in colorectal cancer
Authors: Alexandre Calon, Enza Lonardo, Antonio Berenguer-Llergo, Elisa Espinet, Xavier Hernando-Momblona, Mar Iglesias, Marta Sevillano, Sergio Palomo-Ponce, Daniele V F Tauriello, Daniel Byrom, Carme Cortina, Clara Morral, Carles Barceló, Sebastien Tosi, Antoni Riera, Camille Stephan-Otto Attolini, David Rossell, Elena Sancho, Eduard Batlle
Journal: Nature Genetics (2015)
Antiarrhythmic Activity of Quinine in Humans
Authors: Robert Sheldon, Henry Duff, Mary Lou Koshman
Journal: Circulation (1995)

Background Quinine is the diastereomer of quinidine. In dogs, it has similar effects on conduction time but does not prolong epicardial repolarization time or ventricular refractoriness. It has antiarrhythmic effects in both cats and dogs. We assessed the antiarrhythmic potential of quinine in suppressing ventricular arrhythmias in humans. Methods and Results Patients underwent open-label, dose-ranging trials of quinine with daily doses of 600, 1200, and 1800 mg in a twice-daily dosing regimen. In 17 patients with frequent spontaneous ventricular ectopy, oral quinine suppressed arrhythmia in 11 of 12 patients who finished the study and was not tolerated by 4 patients, and 1 patient withdrew from the study. The mean effective daily dosage was 927 mg, the mean effect trough serum level was 11 μmol/L (range, 4 to 17 μmol/L), and the half-life was 20±7 hours. In a second open-label, dose-ranging trial in 10 patients with inducible ventricular tachycardia and reduced left ventricular systolic function (left ventricular ejection fraction, 35±16%), quinine suppressed inducibility of ventricular tachycardia in 3 of 10 patients. At a basic pacing cycle length of 500 milliseconds, ventricular effective refractory period was prolonged (279±21 versus 247±10 milliseconds, quinine versus drug free, P =.003). In the remaining patients, ventricular tachycardia cycle length was prolonged (373±48 versus 253±30 milliseconds, quinine versus drug free, P &lt;.001). The corrected QT interval was not prolonged. Conclusions Quinine is an effective and convenient antiarrhythmic drug for the suppression of ventricular arrhythmias in humans.
Anaemia in pregnancy associated with "big spleen disease".
Authors: P. J. Hamilton, D. A. Gebbie, M. S. Hutt, F. Lothe, N. E. Wilks
Journal: BMJ (1966)

We have previously reported an association between idiopathic tropical splenomegaly, lymphocytic infiltration of the hepatic sinusoids, hyperglobulinaemia, and a raised fluorescent antibody titre to malaria, and have suggested that this is due to an abnormal immune response to malaria, possibly connected with Plasmodium malariae infection (Gebbie et al., 1964; Marsden et ai., 1965).This syndrome is known locally as big spleen disease, and is referred to by that title in this paper.These patients usually have a chronic anaemia due to a shortened red-cell survival (Marsden et al., 1965).In one series 13 of the 15 females were pregnant or lactating (Gebbie et al., 1964).We now present clinical, haematological, biochemical, and immunological studies on a series of patients with anaemia in pregnancy associated with big spleen disease.The relation of these cases to the overall picture of anaemia in pregnancy as seen in Kampala is reported. Materials and MethodsOf 8,579 patients attending the obstetric service of Mulago Hospital in 1964 95 (1.1%) were admitted to hospital because of anaemia, with a haemoglobin of less than 7 g./100 ml.Detailed studies of these patients, including haemoglobin, paper electrophoresis, glucose-6-phosphate-dehydrogenase assay (Doxiadis, 1961), liver-function tests, and liver biopsy, enabled us to classify the cause of anaemia as shown in Table I.TABLE I.-Anaemia in Pregnancy: 95 Antenatal Cases Admitted for Anaemia in 1964 Hfookworm infestation and iron deficiency ..Anaemia associated with big spleen disease Anaemia associated with megaloblastic change and big spleen disease Megaloblastic Acute haemolytic with no splenomegaly and normal liver biopsy .. MiscellaneousNo. of Cases ..
Unusual complications of acute pancreatitis
Authors: L.-C. Chang, H.-P. Wang, M.-Y. Wang, K.-L. Liu
Journal: Gut (2009)

A 62-year-old woman with hypertension, type 2 diabetes mellitus, and end-stage renal disease under regular haemodialysis presented in the emergency department with progressive nausea, vomiting and abdominal pain. The abdomen was soft, with hypoactive bowel sounds, tympanic and non-tender. The haemogram revealed white …
Vanishing Vacancies in Residencies
Authors: Rose Tracy
Journal: JAMA (1975)

Physicians seeking first-year residencies in graduate medical education are having difficulty finding such vacancies. Graduates of foreign medical schools already in this country who have received their certificates from the Educational Commission on Foreign Medical Graduates (ECFMG), after having passed its July examination, are dismayed to learn that few if any hospitals have vacancies for first-year residents, and that most program directors will not be making appointments until March for July 1976 openings. Some foreign graduates report that they have written, telephoned, and visited dozens of hospitals, to no avail. The first year of graduate training, still specified in most state medical practice acts as an internship year, is a prerequisite in most states to take the examination for licensure to practice medicine, regardless of the candidate's previous practice in countries other than the United States or Canada. To find a first-year position in the fall of the year has
Noninvasive Coronary Angiography
Authors: Mario J. Garcia
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Right to Know Your Genetic Parents: From Open-Identity Gamete Donation to Routine Paternity Testing
Authors: An Ravelingien, Guido Pennings
Journal: The American Journal of Bioethics (2013)

Over the years a number of countries have abolished anonymous gamete donation and shifted toward open-identity policies. Donor-conceived children are said to have a fundamental "right to know" the identity of their donor. In this article, we trace the arguments that underlie this claim and question its implications. We argue that, given the status attributed to the right to know one's gamete donor, it would be discriminatory not to extend this right to naturally conceived children with misattributed paternity. One way to facilitate this would be through routine paternity testing at birth. While this proposal is likely to raise concerns about the conflicting interests and rights of other people involved, we show that similar concerns apply to the context of open-identity gamete donation. Unless one can identify a rational basis for treating the two groups differently, one's stance toward both cases should be the same.
VITAMIN C AND EXFOLIATIVE DERMATITIS.
Authors: A. TICKNER, A. BASIT
Journal: British Journal of Dermatology (1960)

Journal Article VITAMIN C AND EXFOLIATIVE DERMATITIS. Get access A. TICKNER, A. TICKNER Institute of Dermatology, St. John's Hospital for Diseases ofthe Skin, Lisle St., London, W.C.2 Search for other works by this author on: Oxford Academic Google Scholar A. BASIT A. BASIT Institute of Dermatology, St. John's Hospital for Diseases ofthe Skin, Lisle St., London, W.C.2 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 72, Issue 11, 1 November 1960, Pages 403–408, https://doi.org/10.1111/j.1365-2133.1960.tb13826.x Published: 01 November 1960
Epidermal nuclear immunofluorescence: serological correlations supporting an in vivo reaction
Authors: ZE-YI CHEN, R.L. DOBSON, S.K. AINSWORTH, R.M. SILVER, H.R. MARICQ
Journal: British Journal of Dermatology (1985)

Journal Article Epidermal nuclear immunofluorescence: serological correlations supporting an in vivo reaction Get access ZE‐YI CHEN, ZE‐YI CHEN Department of Dermatology, Medical University of South Carolina, Charleston, South Carolina 29425, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar R.L. DOBSON, R.L. DOBSON Department of Dermatology, Medical University of South Carolina, Charleston, South Carolina 29425, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar S.K. AINSWORTH, S.K. AINSWORTH Department of Pathology, Medical University of South Carolina, Charleston, South Carolina 29425, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar R.M. SILVER, R.M. SILVER Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar H.R. MARICQ H.R. MARICQ Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, U.S.A. Dr H.R. Maricq, Division of Rhcumatology & Immunology, Medical University of South Carolina, 171 Ashley Avenue, Charleston, South Carolina 29425, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 112, Issue 1, 1 January 1985, Pages 15–22, https://doi.org/10.1111/j.1365-2133.1985.tb02286.x Published: 01 January 1985 Article history Accepted: 01 May 1984 Published: 01 January 1985
Handbook of Psychiatric Consultation
Authors: Martin Grotjahn
Journal: JAMA (1969)

With a wide theoretical scope and down-to-earth practical suggestions on the consultation process, this<i>Handbook</i>describes many different clinical situations, including consultations to agencies. It is a scholarly, general, and yet detailed guidance for the psychiatric consultation. It is often didactic, with explicit directions about procedures, techniques, possible dangers, and mistakes. As Henry Brosin states in his foreword, this volume becomes a "true handbook," as it is called in the title, as well as a "specialty text." There are sections on the fundamentals of the consultation process and useful chapters on diagnosis and management. There are also sections on the special aspects of consultations with surgeons, pediatricians, and community services. A teaching program is outlined in detail, as is a consultation liaison program. The guidance to the literature is thoroughgoing and carefully prepared. Dr. Schwab has attempted a comprehensive task, and he has succeeded in furnishing us with a text