tbuckley/cabot-search huggingface dataset:
Uptake of Ga-67 in the Cardiac Region in Hypersensitivity Angiitis
Authors: PANNA J. SHAH, WALTON W. SHREEVE
Journal: Clinical Nuclear Medicine (1981)

Although Ga-67 can be used to recognize various inflammations of the heart and pericardium, it is seldom used to evaluate the inflammatory process of a myocardial infarction because of lack of specificity, lack of early uptake, and other factors. However, inadvertent recognition on routine Ga-67 scans is always a possibility and has been reported once before. Here described is another case of silent, multiple myocardial infarction seen by Ga-67 scan as a consequence of multiple organ involvement with hypersensitivity angiitis. This incidental finding was the only indication of direct cardiac involvement at the time of the patient's death by cardiac arrest on the same day as the Ga-67 scan.
Nottingham Clinico-Pathological Response Index (NPRI) after Neoadjuvant Chemotherapy (Neo-ACT) Accurately Predicts Clinical Outcome in Locally Advanced Breast Cancer
Authors: Tarek M. Abdel-Fatah, Graham Ball, Andrew H.S. Lee, Sarah Pinder, R. Douglas MacMilan, Eleanor Cornford, Paul M. Moseley, Rafael Silverman, James Price, Bruce Latham, David Palmer, Arlene Chan, Ian O. Ellis, Stephen Y.T. Chan
Journal: Clinical Cancer Research (2014)

Abstract Purpose: There is a need to identify more sensitive clinicopathologic criteria to assess the response to neoadjuvant chemotherapy (Neo-ACT) and guide subsequent adjuvant therapy. Experimental Design: We performed a clinicopathologic assessment of 426 patients who had completed Neo-ACT for locally advanced breast cancer (LABC) with a median follow-up of 70 months. Patients were divided into a training set treated with anthracycline combination chemotherapy (n = 172); an internal validation set treated with anthracycline and taxane (n = 129); and an external validation set treated with anthracycline with or without taxane (n = 125). Results: A multivariate Cox regression model demonstrated the absence of fibrosis, presence of lymphovascular invasion, increasing number of lymph node metastases, and administration of hormone therapy were significantly associated with short breast cancer–specific survival (BCSS) and disease-free survival (DFS); Ps &amp;lt; 0.01, while reduction of tumor size was associated with DFS (P = 0.022). Nottingham Clinico-Pathological Response Indexes (NPRI) were calculated, and four prognostic groups (NPRI-PG) were identified. Patients in prognostic group 2 (NPRI-PG2) for BCSS (66 of 172; 38.4%) have the same prognosis as those who achieved pathologic complete response (pCR; NPRI-PG1; 15%). Receiver-operating characteristic (ROC) curves indicated that the NPRI outperformed the currently used prognostic factors and adding the NPRI improved their performance as a predictor for both BCSS (area under the curve [AUC], 0.88) and DFS (AUC, 0.87). Conclusions: The NPRI predicts BCSS and DFS, with a higher sensitivity than pCR. The NPRI can also improve the sensitivity and specificity of clinicopathologic response as a study endpoint, for assessing response to Neo-ACT, and can serve as a valuable tool for the discovery of future predictive molecular markers. Clin Cancer Res; 21(5); 1052–62. ©2014 AACR.
The CD37-targeted antibody–drug conjugate IMGN529 is highly active against human CLL and in a novel CD37 transgenic murine leukemia model
Authors: K A Beckwith, F W Frissora, M R Stefanovski, W H Towns, C Cheney, X Mo, J Deckert, C M Croce, J M Flynn, L A Andritsos, J A Jones, K J Maddocks, G Lozanski, J C Byrd, N Muthusamy
Journal: Leukemia (2014)
The self-association coiled-coil domain of PML is sufficient for the oncogenic conversion of the retinoic acid receptor (RAR) alpha
Authors: M Occhionorelli, F Santoro, I Pallavicini, A Gruszka, S Moretti, D Bossi, A Viale, D Shing, S Ronzoni, I Muradore, M Soncini, G Pruneri, P Rafaniello, G Viale, P G Pelicci, S Minucci
Journal: Leukemia (2011)
How to deal with competing interests
Authors: Dieneke Hubbeling
Journal: Journal of the Royal Society of Medicine (2009)

Richard Smith and colleagues asserted that authors of journal articles should not only declare financial interests but also other ones.1 Fairness would require that one extends this to medical journals and their editors, given that they can have (financial) interests as well.2 For example it will be in the journal's interests to get advertisements from drug companies. Drug companies are unlikely to advertise in a particular journal, if this journal just published a negative study about their product.

It is not difficult to imagine that soon the list of competing interests will be longer than the original article. Furthermore, the question is whether declaring interests will encourage researchers to report their findings unbiased. Some research suggest that this is not the case.3

Another and perhaps better way to approach the competing interest problem will be to demand that researchers make their actual data publicly available. In that case, at least for empirical studies, one can check the strong and weak points of the analysis and authors will know beforehand that this will happen.
An evaluation of the preferences of patients with psoriasis between systemic psoralen plus ultraviolet A and bath psoralen plus ultraviolet A
Authors: D. Alshiyab, M.F. Chin, C. Edwards, A.V. Anstey
Journal: British Journal of Dermatology (2014)

Journal Article An evaluation of the preferences of patients with psoriasis between systemic psoralen plus ultraviolet A and bath psoralen plus ultraviolet A Get access D. Alshiyab, D. Alshiyab Department of Dermatology Faculty of Medicine Jordan University of Science and Technology Irbid Jordan Search for other works by this author on: Oxford Academic Google Scholar M.F. Chin, M.F. Chin Department of Dermatology University Hospital of Wales Cardiff U.K Search for other works by this author on: Oxford Academic Google Scholar C. Edwards, C. Edwards Academic Dermatology Unit St Woolos Hospital Newport U.K Search for other works by this author on: Oxford Academic Google Scholar A.V. Anstey A.V. Anstey Academic Dermatology Unit St Woolos Hospital Newport U.KCardiff University Cardiff U.K Correspondence: Alexander V. Anstey. E‐mail: alex.anstey@wales.nhs.uk Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 172, Issue 5, 1 May 2015, Pages 1457–1458, https://doi.org/10.1111/bjd.13561 Published: 01 May 2015
Dye Dilution Curves in Cyanotic Congenital Heart Disease
Authors: H. J. C. SWAN, J. ZAPATA-DIAZ, EARL H. WOOD
Journal: Circulation (1953)

Use of cuvette and earpiece oximeters facilitates the recording of the immediate dilution pattern of the dye T-1824 (Evans blue) in the arterial blood. In patients with venoarterial shunts the pattern of the dilution curves differs from normal. Quantitative analysis of such curves from patients with cyanotic congenital heart disease has been undertaken to establish the proportion of blood which bypassed the pulmonary circulation. The results obtained have been compared with estimates of the volume of the shunt from cardiac catheterization data and related to the arterial oxygen saturation.
Hypnosis in Medical Practice
Authors: Harold Rosen
Journal: JAMA (1961)

Training in hypnosis, like training in any other clinical discipline, must be conducted in a medical school or teaching hospital if it is to be adequate for medical purposes. It should be patient-centered rather than hypnosis-centered. It should be provided by the department of psychiatry in collaboration with those other departments of the medical school or teaching hospital in which the physicianin-training is primarily interested. It should provide him with a well-rounded clinical experience in relation to his type of practice.
The Protein Concentration in the Proximal Tubule of the Dog*
Authors: John H. Dirks, James R. Clapp, Robert W. Berliner
Journal: Journal of Clinical Investigation (1964)

The mammalian proximal tubular fluid is gen- erally considered to contain a low but definite pro- tein concentration (1-3).The degree of glomeru- lar capillary membrane permeability has been con- sidered to range from that of a perfect ultrafilter to one yielding a protein concentration of 30 mg per 100 ml or more in the immediate filtrate.The most obvious evidence that protein is present in the glomerular filtrate is the presence of plasma proteins in the urine of normal man, dog, and rat.Estimates of the albumin in normal human urine, based upon a number of different methods, range from 15 to 31 mg per 24 hours (4-8).This amount of albumin could easily be accounted for by a concentration less than 1 mg per 100 ml in the glomerular filtrate provided none was absorbed.The only direct estimate of protein in the mammalian nephron is to be found in the micropuncture studies of Walker, Bott, Oliver, and MacDowell (9).The protein concentration in 41 samples of glomerular and proximal tubular fluid from the guinea pig and the rat was found to range from less than 30 mg per 100 ml to less than 200 mg per 100 ml.Earlier, Wearn and Richards (10) had found no protein in 11 frog glomerular samples and concluded that the glomerular filtrate was protein free.The recent adaptation of micropuncture tech- nique to the dog nephron by Clapp, Watson, and Berliner (11) made possible a direct estimation of protein concentration in the dog proximal tubule with a more sensitive method for the de- tection and identification of protein.The results indicate that the concentration of protein is ap- proximately an order of magnitude lower than
Hepatitis C virus–infected women have a higher risk of advanced fibrosis and graft loss after liver transplantation than men
Authors: Jennifer C. Lai, Elizabeth C. Verna, Robert S. Brown, Jacqueline G. O'Leary, James F. Trotter, Lisa M. Forman, Jeffrey D. Duman, Richard G. Foster, Todd R. Stravitz, Norah A. Terrault
Journal: Hepatology (2011)

In natural history studies of hepatitis C virus (HCV) infection, women have a lower risk of disease progression to cirrhosis. Whether female sex influences outcomes of HCV in the posttransplantation setting is unknown. All patients transplanted for HCV-related liver disease from 2002-2007 at five United States transplantation centers were included. The primary outcome was development of advanced disease, defined as biopsy-proven bridging fibrosis or cirrhosis. Secondary outcomes included death, graft loss, and graft loss with advanced recurrent disease. A total of 1,264 patients were followed for a median of 3 years (interquartile range, 1.8-4.7), 304 (24%) of whom were women. The cumulative rate of advanced disease at 3 years was 38% for women and 33% for men ( P = 0.31), but after adjustment for recipient age, donor age, donor anti-HCV positivity, posttransplantation HCV treatment, cytomegalovirus infection and center, female sex was an independent predictor of advanced recurrent disease (hazard ratio [HR], 1.31; 95% confidence interval [CI], 1.02-1.70; P = 0.04). Among women, older donor age and treated acute rejection were the primary predictors of advanced disease. The unadjusted cumulative 3-year rates of patient and graft survival were numerically lower in women (75% and 74%, respectively) than men (80% and 78%, respectively), and in multivariable analyses, female sex was an independent predictor for death (HR, 1.30; 95% CI, 1.01-1.67; P = 0.04) and graft loss (HR, 1.31; 95% CI, 1.02-1.67; P = 0.03). Conclusion: Female sex represents an underrecognized risk factor for advanced recurrent HCV disease and graft loss. Further studies are needed to determine whether modification of donor factors, immunosuppression, and posttransplantation therapeutics can equalize HCV-specific outcomes in women and men. (Hepatology 2011;)
Cytology of systemic mastocytosis
Authors: Barbara J. Bain, A. J. Marks
Journal: American Journal of Hematology (2009)

come from teaching and research institutions in France or abroad, or from public or private research centers.L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. Cytology of systemic mastocytosis
Abstract 2849: Optimization and pharmacokinetic characterization of potent CXCR4 antagonist CovX-Bodies
Authors: Julia A. Coronella, Yanwen Fu, Kim Johnson, Sukumar Sakamuri, John Rizzo, Dorian Willhite, Joselyn Del Rosario, Venkata Doppalapudi, Abhijit Bhat, Nancy Levin
Journal: Cancer Research (2012)

Abstract Here we describe a series of CXCR4 antagonist CovX-Bodies, produced by covalently attaching CXCR4 antagonist peptides to a humanized IgG1 molecule with the goal of producing molecules with the potency and specificity of peptides and the pharmacokinetic parameters of an antibody. Extensive SAR was performed on peptides derived from T140, a highly charged 14 amino acid cyclic peptide containing 4 Arginine residues. Both the free peptides and the associated CovX-bodies were potent antagonists of CXCR4 in vitro, and SAR studies were consistent with a model of both allosteric and orthosteric inhibition. However, in vivo pharmacokinetic (PK) studies revealed an unexpected and CXCR4-independent disappearance of the CovX-Bodies from circulation, such that approximately 10% of the injected CovX-Body remained in circulation 1 hour after i.v. injection into mice. Based on the known nonspecific cell-penetrating properties of Arginine-rich peptides, we hypothesized that Arginine replacement and charge neutralization would improve the pharmacokinetics of the CovX-Bodies. We identified substitutions that could replace up to 3 of the 4 Arg residues while retaining potent CXCR4 binding and antagonism, but Arg2 was obligate. However, these CovX-Bodies were only modestly improved in PK, indicating that that the anomalous in vivo behavior was not solely a function of charge or the net number of Arg residues. Only the replacement of Arg2 significantly improved the pharmacokinetics of the CovX-Bodies, but also resulted in a loss of CXCR4 antagonism. Extensive SAR failed to identify a suitable replacement residue for Arg2, nor did alternative structural forms such as 5 member, bicyclic, or reversed ring molecules have significantly improved pharmacokinetics. Based on these data, we conclude that the specific property of the peptide that allows potent inhibition of CXCR4, of which Arg2 is an integral component, also mediates binding to moieties other than CXCR4, leading to the depletion of these molecules from circulation. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2849. doi:1538-7445.AM2012-2849
The Splicing Factor Crooked Neck Associates with the RNA-Binding Protein HOW to Control Glial Cell Maturation in Drosophila
Authors: Gundula Edenfeld, Gloria Volohonsky, Karin Krukkert, Elke Naffin, Uwe Lammel, Alexandra Grimm, Daniel Engelen, Adriana Reuveny, Talila Volk, Christian Klämbt
Journal: Neuron (2006)
Doctors' age at domestic partnership and parenthood: cohort studies
Authors: Michael J Goldacre, Jean M Davidson, Trevor W Lambert
Journal: Journal of the Royal Society of Medicine (2012)

Objective To report on doctors’ family formation. Design Cohort studies using structured questionnaires. Setting UK. Participants Doctors who qualified in 1988, 1993, 1996, 1999, 2000 and 2002 were followed up. Main Outcome Measures Living with spouse or partner; and doctors’ age when first child was born. Results The response to surveys including questions about domestic circumstances was 89.8% (20,717/23,077 doctors). The main outcomes – living with spouse or partner, and parenthood – varied according to age at qualification. Using the modal ages of 23–24 years at qualification, by the age of 24–25 (i.e. in their first year of medical work) a much smaller percentage of doctors than the general population was living with spouse or partner. By the age of 33, 75% of both women and men doctors were living with spouse or partner, compared with 68% of women and 61% of men aged 33 in the general population. By the age of 24–25, 2% of women doctors and 41% of women in the general population had a child; but women doctors caught up with the general population, in this respect, in their 30s. The specialty with the highest percentage of women doctors who, aged 35, had children was general practice (74%); the lowest was surgery (41%). Conclusions Doctors are more likely than other people to live with a spouse or partner, and to have children, albeit typically at later ages. Differences between specialties in rates of motherhood may indicate sacrifice by some women of family in favour of career.
Improved affinity AFP-specific T cell receptor for hepatocellular carcinoma
Authors: Andrew B Gerry, Nicholas J Pumphrey, Roslin Y Docta, Joanna E Brewer, Alan D Bennett, Bent K Jakobsen
Journal: Journal for ImmunoTherapy of Cancer (2013)

Meeting abstracts We have previously demonstrated that an improved affinity TCR generated against NYESO-1 has shown remarkable efficacy in clinical studies in multiple myeloma ([NCT01352286][1]). The same TCR is also being tested in synovial sarcoma ([NCT01343043][2]), melanoma ([NCT01350401][3])
Alcohol and the Heart
Authors: JOHN P. SHEEHAN
Journal: Annals of Internal Medicine (1983)

Letters and Corrections1 June 1983Alcohol and the HeartJOHN P. SHEEHAN, M.D.JOHN P. SHEEHAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-98-6-1022 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The report of Greenspon and Schaal (1), and the accompanying editorial (2), highlighted the arrhythmogenic effects of alcohol. Neither communication, however, mentioned alcohol-related hypomagnesemia as an important factor both in the precipitation of atrial fibrillation and its responsiveness to therapy. All patients in the study by Greenspon and Schall surprisingly were reported to have normal serum magnesium levels, and Ettinger and associates (3) did not document the magnesium levels of their patients with "holiday heart," although severe hypokalemia was recorded. One would expect at least 25% of all chronic alcoholics to have subnormal serum magnesium levels (4);...References1. GREENSPON A and SCHAAL S. The "holiday heart": electrophysiologic studies of alcohol effects in alcoholics. Ann Intern Med. 1983;98:135-9. LinkGoogle Scholar2. LUCK J and ENGEL T. Arrhythmias and social drinking [Editorial]. Ann Intern Med. 1983;98:253. LinkGoogle Scholar3. ETTINGER P, WU C, DE LA CRUZ C, WEISSE A, AHMED S, and REGAN T. Arrhythmias and the "holiday heart": alcohol-associated cardiac rhythm disorders. Am Heart J. 1978;95:555-62. CrossrefMedlineGoogle Scholar4. HEATON F, PYRAH L, BERESFORD C, BRYSON R, and MARTIN D. Hypomagnesemia in chronic alcoholism. Lancet. 1962;2:802-5. CrossrefGoogle Scholar5. SHEEHAN J and WHITE A. Diuretic-associated hypomagnesemia. Br Med J. 1982;285:1157-9. CrossrefMedlineGoogle Scholar1. GREENSPON A and SCHALL S. The "holiday heart": electrophysiologic studies of alcohol effects in alcoholics. Ann Intern Med. 1983;98:135-9. LinkGoogle Scholar2. LUCK J and ENGEL T. Arrhythmias and social drinking [Editorial]. Ann Intern Med. 1983;98:253. LinkGoogle Scholar3. ALTIERI P, GUZMAN P, and GUERRA E. Relative sinus and atrioventricular node dysfunction produced by alcohol. In: Proceedings of the VI World Symposium on Cardiac Pacing. Montreal: PACESYMP; 1979: Chap. 5-9. Google Scholar4. ALTIERI P, BANCH H, and MARTÍNEZ J. Alcohol induced sick sinus syndrome: effect via the autonomic system [Abstract]. IX World Congress of Cardiol. 1982;1:404. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOHN P. SHEEHAN, M.D.Affiliations: Joslin Diabetes Center Boston, MA 02215 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySpecial Aspects of Human Alcohol Withdrawal 1 June 1983Volume 98, Issue 6Page: 1022-1022KeywordsAddictionAlcoholicsAlcoholsAtrial fibrillationHeartHypomagnesemiaLongitudinal studiesMagnesium ePublished: 1 December 2008 Issue Published: 1 June 1983 PDF downloadLoading ...
<scp>d</scp>-Dimer Testing to Select Patients With a First Unprovoked Venous Thromboembolism Who Can Stop Anticoagulant Therapy
Authors: Clive Kearon, Frederick A. Spencer, Denis O'Keeffe, Sameer Parpia, Sam Schulman, Trevor Baglin, Scott M. Stevens, Scott Kaatz, Kenneth A. Bauer, James D. Douketis, Steven R. Lentz, Craig M. Kessler, Stephan Moll, Jean M. Connors, Jeffrey S. Ginsberg, Luciana Spadafora, Jim A. Julian
Journal: Annals of Internal Medicine (2015)

Normal D-dimer levels after withdrawal of anticoagulant therapy are associated with a reduced risk for recurrence in patients with unprovoked venous thromboembolism (VTE) and may justify stopping treatment.To determine whether patients with a first unprovoked VTE and negative D-dimer test result who stop anticoagulant therapy have a low risk for recurrence.Prospective management study with blinded outcome assessment. (ClinicalTrials.gov: NCT00720915).13 university-affiliated clinical centers.410 adults aged 75 years or younger with a first unprovoked proximal deep venous thrombosis or pulmonary embolism who had completed 3 to 7 months of anticoagulant therapy.Anticoagulant therapy was stopped if D-dimer test results were negative and was not restarted if results were still negative after 1 month.Recurrent VTE during an average follow-up of 2.2 years.In 319 patients (78%) who had 2 negative D-dimer results and did not restart anticoagulant therapy, rates of recurrent VTE were 6.7% (95% CI, 4.8% to 9.0%) per patient-year overall (42 of 319), 9.7% (CI, 6.7% to 13.7%) per patient-year in men (33 of 180), 5.4% (CI, 2.5% to 10.2%) per patient-year in women with VTE not associated with estrogen therapy (9 of 81), and 0.0% (CI, 0.0% to 3.0%) per patient-year in women with VTE associated with estrogen therapy (0 of 58) (P = 0.001 for the 3-group comparison).Imprecision in female subgroups. Results may not be generalizable to different D-dimer assays from the one used in the study.The risk for recurrence in patients with a first unprovoked VTE who have negative D-dimer results is not low enough to justify stopping anticoagulant therapy in men but may be low enough to justify stopping therapy in women.Canadian Institutes of Health Research.
AN ACCURATE AND RELIABLE THERMOREGULATOR.
Authors: A. Ronbin
Journal: JAMA (1906)

The multiplicity of thermoregulators on the market is a sufficient proof that none of them is thoroughly satisfactory. A vexatious experience of several years with several instruments resulted in the adoption of the following device which proved entirely satisfactory: <h3>DESCRIPTION.</h3> This apparatus consists of an automatic burner, the same as is used in lighting residences, and thermostat. <h3>Automatic Burner.</h3> —This consists of two electro-magnets which control a small valve. In ordinary usage the magnet opening the valve is brought in action by a push-button which, at the same time, operates a spark coil. As the gas issues it is lighted by the spark. Another push-button operates the magnet which closes the valve and extinguishes the light. To obviate the necessity of a spark coil, I bent one of the springs which operates the valve so that when the latter is closed the gas is not shut off completely, and a