tbuckley/cabot-search huggingface dataset:
Microvascular Complications of Diabetes Mellitus and Glycemic Control
Authors: MARK V. SHEFFIELD
Journal: Annals of Internal Medicine (1987)

Letters and Corrections1 April 1987Microvascular Complications of Diabetes Mellitus and Glycemic ControlMARK V. SHEFFIELD JR., M.D.MARK V. SHEFFIELD JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-106-4-638 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Gwinup (1) is rightly skeptical about drawing premature conclusions from the many prospective trials of the relation of microvascular complications of diabetes mellitus and glycemic control. Data from most large metabolic studies have accumulated over only the past 5 years, and conclusions, especially regarding pathogenesis of specific complications, are preliminary. Further confounding interpretation is a possible genetic predisposition for microvascular disease, especially retinopathy, in patients with the HLA-DR4 antigen.It is of paramount importance, however, to define and recognize the scope of the underlying disease. If treatment merely depended on controlling blood sugar, diabetes would be a...References1. GWINUP G. New modes of insulin administration (Letter). Ann Intern Med. 1986;105:633. LinkGoogle Scholar2. FRIBERGROSENSTOCKSANBORNVAGHFIRASKIN TJGAP. The effect of long-term near normal glycemic control on mild diabetic retinopathy. Ophthalmology. 1985;92:1051-8. CrossrefMedlineGoogle Scholar3. . The Kroc study patients at two years: a report on further retinal changes (Abstract). Diabetes. 1985;34(Suppl 1):39A. Google Scholar4. RASKINPREFRIUNGERSHANNON PARW. The effect of diabetic control on skeletal muscle capillary basement membrane width in patients with type I diabetes mellitus. N Engl J Med. 1983;309:1546-50. CrossrefMedlineGoogle Scholar5. RASKINUNGER PR. Hyperglucognemia and its suppression. N Engl J Med. 1978;299:433-6. CrossrefMedlineGoogle Scholar6. PIETRIDUNNRASKIN AFP. The effect of improved levels: a comparison of conventional therapy and subcutaneous insulin infusion. Diabetes. 1980;29:1001-5. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MARK V. SHEFFIELDJR., M.D.Affiliations: University of California Sacramento, CA 95817 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1987Volume 106, Issue 4Page: 638-639KeywordsAntigensBlood sugarDiabetes mellitusGenetic predispositionPathogenesisRetinopathy ePublished: 1 December 2008 Issue Published: 1 April 1987 PDF downloadLoading ...
Managing diabetes in residential and nursing homes
Authors: R. Tattersall, S. Page
Journal: BMJ (1998)

The prevalence of diabetes in the elderly is around 10% and it imposes an enormous burden on healthcare systems. In America in 1992 nursing home care for people with diabetes cost $1.83 billion.1 Elderly diabetics have much microvascular and macrovascular disease and are two to three times more likely to need hospital admission than their non-diabetic counterparts.2 One might expect a higher prevalence of diabetes and its complications in residential or nursing homes. Several American studies have found diabetes in 20% of nursing home residents,3 and in one almost 90% of diabetic residents had coronary artery disease, strokes, or peripheral vascular disease—with 6.4 major diagnoses compared with only 2.4 in non-diabetic residents.4 In Alabama (and probably England) nursing home patients generate a disproportionately large number of out of hours calls.5

In a recent issue of the BMJ Benbow and coworkers surveyed 44 residential and nursing homes in Liverpool comparing 109 diabetic residents with 107 age and …
RESULTS OF FACIO-HYPOGLOSSAL ANASTOMOSIS FOR FACIAL PALSY.
Authors: ALFRED S. TAYLOR
Journal: JAMA (1906)

A description of the surgical technic as well as the histories in three cases of facio-hypoglossal anastomosis appeared in the<i>Medical Record</i>of Feb. 27, 1904. These cases were presented before the Surgical Section of the New York Academy of Medicine in January, 1904. Because of the short postoperative period—four, three and two months, respectively—no results had appeared at that time. As each of the three has developed motor power on the paralyzed side, the interest of the cases perhaps justifies a second report, even though the return of power is not complete. Moreover, four additional cases have been operated on. There has not yet been time for the return of motor power, but there are in each case points of considerable interest when compared with the preceding series. In general terms, the operation consists in dividing the facial nerve at its exit from the stylo-mastoid foramen, exposing the hypoglossal
Demonstration of Cerebrospinal Fluid Leakage on Radionuclide Cisternography by SPECT/CT
Authors: Gül Nihal Nursal, Ali Fuat Yapar
Journal: Clinical Nuclear Medicine (2014)

We report a case of a 37-year-old woman with severe headache provoked by postural changes who was referred to the nuclear medicine department for radionuclide cisternography to demonstrate suspected cerebrospinal fluid leakage. There was an increased uptake laterally on the left paraspinal region of upper thoracal spine and posteriorly on the upper cervical region. Fused SPECT/CT images located the exact leakage site as at the first costovertebral junction level on the left side laterally and on the posterior region of the first and second cervical spine. The treatment with epidural blood patch was successful.
Economic Conditions and Obesity—Reply
Authors: David S. Ludwig
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Twenty to 40 year follow up of infantile hiatal hernia.
Authors: B T Johnston, I J Carre, P S Thomas, B J Collins
Journal: Gut (1995)

The aim of this study was to assess clinical and radiological findings of gastro-oesophageal reflux in adults who were diagnosed as having a hiatal hernia in infancy or early childhood. One hundred and eighteen patients with a minimum age of 20 who were diagnosed as having a hiatal hernia in childhood were interviewed; barium meal examination was performed in 96 of these cases. Ninety four patients had not required surgery for their hernia. The hiatal hernia persisted in 53% of these patients and 46% experienced heartburn at least monthly but in only three was this severe. Heartburn was significantly more common in patients in whom reflux was seen on barium meal. The consumption of antacids was significantly lower (20% v 46%) in patients who responded well to treatment as children. Eighteen of 24 patients who underwent surgery as children experienced heart-burn monthly but in only one patient was this severe. Two patients underwent endoscopy at their request because of symptoms during this follow up. Both had Barrett9s oesophagus. In conclusion, despite the persistence of the hiatal hernia in half of the non-surgically treated patients, few complained of significant symptoms. Effective treatment in childhood was associated with a significant reduction in antacid consumption for heartburn as adults. The finding of Barrett9s oesophagus in two patients high-lights a possible role for endoscopic screening in this patient group.
Accuracy of gas analysis in lung function laboratories.
Authors: D J Chinn, Y Naruse, J E Cotes
Journal: Thorax (1986)

Fifty lung function laboratories in England and Wales analysed test gas mixtures of carbon monoxide and helium. Most of them also analysed mixtures of oxygen and carbon dioxide in nitrogen. The percentage accuracy of the results was within 1% of the expected value in only 14% of determinations of carbon monoxide concentration, 28% for carbon dioxide, 37% for helium, and 48% for oxygen. The accuracy of ratios of two concentrations of helium and carbon monoxide was better than that of the individual gas samples. Overall the variation in results between laboratories was wide, the coefficient of variation ranging from about 3% for analysis of helium to 9% for carbon dioxide. This variation affected the values calculated for carbon monoxide transfer factor, where 20% were in error by more than 5%, and for the calculated value of the respiratory exchange ratio, where the interlaboratory coefficient of variation was about 10%. Errors in analysis were due to unsatisfactory calibration of analysers; five oxygen analysers had large zero errors; five carbon monoxide analysers and one helium analyser had notably curvilinear calibration curves. Insufficient information was obtained to ascertain the nature of the errors in analysis of carbon dioxide. Given the improvements in instrumentation, these results are evidence for deterioration in analytical standards in lung function laboratories from the standards of 20 years ago.
Evaluation of Capillary Collection System for HbA1c Specimens
Authors: Ellen M Voss, George S Cembrowski, Becky L Clasen, Martha L Spencer, Michael B Ainslie, Broatch Haig
Journal: Diabetes Care (1992)

Objective We evaluated the accuracy and stability of a capillary HbA1c collection system for use with a high-performance liquid chromatography analyzer. Research Design and Methods The collection system requires that 5 ul blood is drawn into a calibrated capillary tube, which is then placed into a vial of stabilizing solution and sent for analysis. The study was conducted on simultaneously drawn capillary and venous blood specimens from 47 pediatric diabetes patients. Accuracy was determined by comparing the capillary to the venous HbA1c values. Stability was measured by analyzing 17 capillary specimens over 3 wk. Results There was excellent agreement between the capillary and venous HbA1c values (capillary 0.959, venous +0.494, R2 = 98.7%). The capillary HbA1c values were 0.2% higher than the venous HbA1c values and decreased gradually over time (0.1% HbA1c/week) when stored at room temperature. Conclusions The Bio-Rad (Richmond, CA) collection system is accurate, stable, and simple to use.
Oral Contraceptives and Myocardial Infarction
Authors: Charles H. Hennekens, Brain MacMahon
Journal: New England Journal of Medicine (1977)

Present knowledge of the risks and benefits of oral contraceptives has recently been extended in a report from a prospective study by Vessey et al.1 Women who used oral contraceptives at the start of the study later experienced an excess of hospital referrals for cerebrovascular disease, cervical erosion, skin disorders, self-poisoning, migraine, venous thrombosis and embolism, hay fever, gallbladder disease, amenorrhea and sterility; they showed fewer than expected hospital referrals for cancer, benign lesions of the breast, menstrual disorders other than amenorrhea, duodenal ulcer and retention cysts of the ovary. Clearly, more data are needed before conclusions can be drawn . . .
HLA-DR4 does not predispose to higher amounts of rheumatoid factors in healthy persons.
Authors: T L Vischer, V Von Fliedner
Journal: Annals of the Rheumatic Diseases (1983)

Correspondence HLA-DR4 does not predispose to higher amounts of rheumatoid factors in healthy persons SIR, Several authors have reported the possible association between rheumatoid arthritis (RA) and the HLA-DR4
Thy-1, a Novel Marker for Angiogenesis Upregulated by Inflammatory Cytokines
Authors: Wen -Sen Lee, Mukesh K. Jain, Burak M. Arkonac, Dorothy Zhang, Shyh-Yu Shaw, Saori Kashiki, Koji Maemura, Shwu-Luan Lee, Norman K. Hollenberg, Mu-En Lee, Edgar Haber
Journal: Circulation Research (1998)

Abstract —We identified the cell surface glycoprotein Thy-1 on the endothelium of newly formed blood vessels in four models of angiogenesis in adult rats. Anti–Thy-1 staining showed that Thy-1 was upregulated in adventitial blood vessels after balloon injury to the carotid artery. Preabsorption with a rat Thy-1–Ig fusion construct eliminated all immunoreactivity and thus confirmed the specificity of the Thy-1 staining. Thy-1 was also expressed in the endothelium of small blood vessels formed after tumor implantation in the cornea, in periureteral vessels formed after ligation of the renal artery, and in small blood vessels of the uterus formed during pregnancy. In contrast with its expression during adult angiogenesis, Thy-1 was not expressed in the endothelium of blood vessels during embryonic angiogenesis. In vitro, the inflammatory cytokines interleukin-1β and tumor necrosis factor-α upregulated Thy-1 mRNA by 8- and 14-fold, respectively. Vascular endothelial growth factor, basic fibroblast growth factor, transforming growth factor-β, and platelet-derived growth factor-BB had no effect on Thy-1 mRNA. Thus, Thy-1 appears to be a marker of adult but not embryonic angiogenesis. The upregulation of Thy-1 by cytokines but not growth factors indicates the importance of inflammation in the pathogenesis of adult angiogenesis.
Two-year biochemical, virological, and histological follow-up in patients with chronic hepatitis C responding in a sustained fashion to interferon alfa-2b treatment
Authors: Olle Reichard, Hans Glaumann, Aril Frydén, Gunnar Norkrans, Robert Schvarcz, Anders Sönnerborg, Zhi-Bing Yun, Ola Weiland
Journal: Hepatology (1995)

Fourteen patients with chronic hepatitis C who had a sustained response to a 60-week interferon alfa-2b treatment course were followed, biochemically and virologically, 2 years after treatment cessation. Biopsies were repeated in 12 of 14 for histological and virological evaluation at 2-year follow-up. All 14 patients had normal serum alanine transaminase (s-ALT) levels and were negative for hepatitis C virus (HCV) RNA in serum during treatment and at short-term follow-up 6 months post-treatment. At 2-year follow-up, 13 patients still had normal ALT levels (< 0.6 mukat/L for women; < 0.8 mukat/L for men), 1 a near normal level (0.76 mukat/L); all were HCV RNA negative in serum, and 11 of 12 also in the liver. Liver histology improved during treatment and remained stable during the 2-year follow-up. The authors conclude that most sustained responders, who have normal ALT levels and are nonviremic at short-term follow-up 6 months after interferon treatment, will continue to have a durable long-term response without relapse of the viremia.
Uterus, Fallopian Tube, Ovary and Vagina-Sparing Laparoscopic Cystectomy: Technical Description and Results
Authors: Xavier Gamé, Richard Mallet, Julien Guillotreau, Nathalie Berrogain, Marc Mouzin, Christophe Vaessen, Jean-Pierre Sarramon, Bernard Malavaud, Pascal Rischmann
Journal: European Urology (2006)
Healthy Children Ready to Learn
Authors: Antonia C. Novello
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pollutants as developmental toxicants in aquatic organisms.
Authors: J S Weis, P Weis
Journal: Environmental Health Perspectives (1987)

Pollutants, by disrupting metabolic processes, can interfere with development, and, at critical periods of development, can act as teratogens. Such interference with normal development can be used as a bioassay. Some screening tests are based on this phenomenon. As teratogens, pollutants are fairly nonspecific. Many different classes may elicit the same developmental responses. Mechanisms of teratogenicity include disruption of mitosis, interference with transcription and translation, metabolic disturbances in energy utilization, and nutritional deficits. These in turn interfere with cell interactions, migration, and growth. In aquatic organisms, environmental conditions can be critical. Interactions of pollutant effects with salinity and with temperature have been reported. Interactions between toxicants have also been studied; both synergism and antagonism have been reported. Most reports of teratogenesis have been qualitative. Quantitation has usually been in the form of percentages of embryos affected, but when severity of effect is indexed, more critical analysis is allowed. When effects of other developmental processes such as growth are analyzed, quantitation is readily achieved. Regeneration is an especially useful model of both differentiation and growth. These two components of regeneration can be separately analyzed. Dose-response relationships are readily apparent. In comparison to mammalian embryos, the use of embryos of many aquatic species for testing toxicants has certain advantages, including lower cost and maintenance and shorter development times. They respond to many of the same teratogens. A special advantage is availability for continual examination during development so that abnormalities can be observed and recorded as they arise.
Pneumothorax as a Complication of Placement of a Nasoenteric Tube
Authors: Judith M. Aronchick
Journal: JAMA (1984)

<h3>History</h3> A 68-year-old mentally retarded woman was hospitalized for evaluation of severe anemia because of a deficiency of iron. On admission, her hemoglobin level was 4.7 g. During the examination, she was observed to be severely depressed, and her nutritional status obviously was poor. Because she refused to eat, placement of a nasoenteric tube was attempted for alimentation. Roentgenograms of the chest were obtained after passage of the tube. Figure 1, left, shows the malpositioned feeding tube passing down the right main bronchus and lying coiled in the pleural space. Figure 1, right, is a film obtained several hours later. <h3>Diagnosis</h3> Right-sided pneumothorax. The roentgenograms demonstrated that a right-sided pneumothorax had developed (Fig 1), produced by perforation of the right main bronchus by a malpositioned nasoenteric tube. <h3>Comment</h3> Nasoenteric tubes are used frequently as a means of alimentation in hospitalized patients. The feeding tube is frequently a thin plastic catheter
Former Peruvian government censured over sterilisations
Authors: X. Bosch
Journal: BMJ (2002)

Alberto Fujimori, former president of Peru, and three former ministers may be accused of genocide by Peru's parliament.

A commission concluded that thousands of Peruvians—mostly poor indigenous people—underwent compulsory surgical sterilisation that resulted in damage to their dignity and physical integrity including deaths due to improper health care.

The report on the “voluntary contraceptive surgery activities” …
The Scientific Basis Of Yoga
Authors: K. N. Udupa
Journal: JAMA (1972)

<h3>To the Editor.—</h3> In order to assess the validity of claims of merit, at Banaras Hindu University we have initiated an extensive study on Yogic practices. Some of our observations are being published in Indian medical journals. A carefully conducted physiological, endocrine, metabolic, and neuropsychological study in a group of 12 young, normal, male volunteers (aged 23.0±3.36 years; weighing 123.0± 12.96 lb) undergoing a six-month systematic training course of "Hath Yoga" has shown beneficial effects; reduction in body weight and a significantly improved pattern of respiratory functions, with lowered rate of respiration, increased rate of expansion of the chest, and increased vital capacity and breath-holding time. They also showed evidence of development of resistance against physical stress in terms of stability of respiratory functions. An endocrine and metabolic assessment of these subjects showed enhanced adrenocortical activity, as evidenced by increased 17-hydroxycorticosteroid excretion, reduction in serum cholesterol level, reduction in blood
The Creation of Adam: Divine Funster Decrees We Are What We Eat: Chicken?
Authors: Christina A. Miller
Journal: JAMA (1991)

To the Editor. —  We appreciate Dr Meshberger's 1 article and would like to extend his suggestion that Michelangelo's Creation of Adam portrays  giving intellect to Adam. Most art historians, as well as Dr Meshberger, identify Eve as the figure held in God's left arm, probably because the face is virtually identical to the face of Eve in a nearby section of the Sistine ceiling. We would like to propose an alternative identity for that figure.  The eighth chapter of Proverbs identifies Wisdom as a feminine presence with  at creation. Further, Wisdom's presence at creation is inherent in the eloquent opening passage of John's gospel: In the beginning was the Word, and the  was with God, and the  was God (Revised Standard Version). The Word in the Greek text is logos , understood either as the Greek philosophical ideal of rationality or as divine wisdom.  Michelangelo was
A Comparison of the Efficacy and Tolerability of Solifenacin Succinate and Extended Release Tolterodine at Treating Overactive Bladder Syndrome: Results of the STAR Trial
Authors: C.R. Chapple, R. Martinez-Garcia, L. Selvaggi, P. Toozs-Hobson, W. Warnack, T. Drogendijk, D.M. Wright, J. Bolodeoku
Journal: European Urology (2005)