tbuckley/cabot-search huggingface dataset:
The Effect of Angiocardiographic Contrast Medium on Circulatory Dynamics in Man
Authors: RICHARD BROWN, SHAHBUDIN H. RAHIMTOOLA, GEORGE D. DAVIS, H. J. C. SWAN
Journal: Circulation (1965)

The cardiovascular response to angiographic contrast medium was studied in 28 patients undergoing diagnostic angiocardiography under anesthesia. A transient phase of hypotension and tachycardia similar to that described by other authors was noted. Cardiac output was increased initially by 50 per cent and returned to the base line in 20 minutes. Peripheral blood flow increased by 100 per cent, apparently due to the direct effect of the hyperosmotic solution on the vascular smooth muscle. Hemodilution, maximal 2 to 4 minutes after injection of contrast medium, suggested a transient increase in circulating blood volume. Increased ventricular filling pressures, which were thought to be due to hypervolemia, were associated with increased left ventricular stroke work.
Reviews, Notes, and Listings: When Others Must Choose: Deciding for Patients without Capacity
Authors: Steven Miles
Journal: Annals of Internal Medicine (1993)

Literature of Medicine15 April 1993Reviews, Notes, and Listings: When Others Must Choose: Deciding for Patients without CapacitySteven Miles, MDSteven Miles, MDHennepin County Medical Center, Minneapolis, MN 55415.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-8-199304150-00036 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail When Others Must Choose: Deciding for Patients without CapacityNew York State Task Force on Life and the Law. 288 pages. Albany, New York: Health Research Inc., Health Education Services; 1992. $9.00.A State Commission's goal is to identify and conserve a new mainstream consensus by proposing to amend laws. When Others Must Choose is the seventh report by an influential Task Force convened by Governor Cuomo in 1985 and is a notable event in this genre.The report addresses the troubling public policy issues that guide and constrain health care decisions for incompetent persons. Its circumspect and well-referenced analysis outlines major features ... Author, Article, and Disclosure InformationAffiliations: Hennepin County Medical Center, Minneapolis, MN 55415. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 April 1993Volume 118, Issue 8Page: 654KeywordsAIDSDecision makingHealth careHealth care policyHealth care policy reportsHealth services researchLegislationMedical ethicsNursesPublic policy ePublished: 15 August 2000 Issue Published: 15 April 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
929 ANTI-OXIDANT CURATIVE EFFECT OF A MANUFACTURED HIP/PAP PROTEIN AGAINST FULMINANT HEPATITIS
Authors: N. Moniaux, H. Song, M. Darnaud, K. Garbin, M. Gigou, C. Mitchell, D. Samuel, P. Amouyal, G. Amouyal, C. Brechot, J. Faivre
Journal: Journal of Hepatology (2010)
The 'Growth Disease' in American Institutional Medicine-Reply
Authors: Albert J. Miller
Journal: JAMA (1982)

<h3>In Reply.—</h3> I have had considerable correspondence from physicians concerning my commentary on "The 'Growth Disease' in American Institutional Medicine," but none from administrators or hospital board members. Mr Bader's thoughtful and incisive letter is, therefore, interesting and particularly welcome. It seems to me that the views expressed in my article, which reflect the thinking of most physicians I know, are strikingly consistent with Mr Bader's views. He states that there are reasons other than institutional growth that explain rising medical costs. I certainly agree. He stresses the need for controlling the ambitions of physicians for their particular vested interests. I certainly agree with that. Mr Bader approves of the "corporate governance model" that was outlined in the article and appropriately defines how to strengthen it and what its proper role should be. I have no disagreement. He stresses the need for effective management, and in this he is certainly
Benign postpartum pleural effusion
Authors: KI Gourgoulianis, AH Karantanas, G Diminikou, PA Molyvdas
Journal: European Respiratory Journal (1995)

The conditions of labour appear to favour the development of pleural effusion. The frequency of postpartum pleural effusion was investigated in this study using thoracic ultrasonography. Thirty one postpartum and 22 healthy nonpregnant women of the same age-group were examined, both supine and seated, via an intercostal approach. Seven of the 31 (23%) postpartum women had pleural effusion within 1-24 h of normal delivery. None of the nonpregnant women had pleural effusion. No correlation was found between postpartum pleural effusion and age, weight-gain during pregnancy, duration of labour, use of intravenous fluid, or oxytocin administration. Pleural effusion seems to be a common finding postpartum, but of no clinical significance.
Biomarkers define the clinical response to dexamethasone in community-acquired pneumonia
Authors: Hilde H.F. Remmelts, Sabine C.A. Meijvis, Rik Heijligenberg, Ger T. Rijkers, Jan Jelrik Oosterheert, Willem Jan W. Bos, Henrik Endeman, Jan C. Grutters, Andy I.M. Hoepelman, Douwe H. Biesma
Journal: Journal of Infection (2012)
COMBINED ENDOCARDIAL AND EPICARDIAL ELECTROANATOMIC MAPPING OF A NOVEL PORCINE INFARCT MODEL: A COMPARISON OF NAVX AND CARTO
Authors: Roderick Tung, Shiro Nakahara, Rafael Ramirez, Chi Lai, Daniel Ennis, Michael Fishbein, Paul Finn, Kalyanam Shivkumar
Journal: Journal of the American College of Cardiology (2010)
Is Alcohol Good for Your Health?
Authors: Gary D. Friedman, Arthur L. Klatsky
Journal: New England Journal of Medicine (1993)

In speaking about the role of alcohol in society, Abraham Lincoln observed, “None seemed to think the injury arose from the use of a bad thing but from the abuse of a very good thing.” The article by Gaziano et al.1 in this issue of the Journal again raises the question whether, from the standpoint of one's health, moderate consumption of alcoholic beverages, usually defined as up to two standard drinks per day, is a good thing.Alcohol has been widely consumed through the ages because of its perceived benefits as a social lubricant and for relaxation, mood alteration, and . . .
Functional interaction between nucleus tractus solitarius NK and 5-HT receptors in the inhibition of baroreflex in rats
Authors: M COMET, R LAGUZZI, M HAMON, C SEVOZCOUCHE
Journal: Cardiovascular Research (2004)

Objective: Previous data showed that in the nucleus tractus solitarius (NTS), 5-HT3 receptors are critically involved in the inhibition of cardiac baroreceptor reflex response occurring during the defense reaction. Since stimulation of NTS NK1 receptors has been found to inhibit the baroreflex bradycardia, we examined in this study whether this reflex response is inhibited during the defense reaction via an interaction between NK1 and 5-HT3 receptors.
Delays during Reproduction and Their Effects on the Embryo and Fetus
Authors: Jonathan T. Lanman
Journal: New England Journal of Medicine (1968)

DURING the reproductive process, various kinds of naturally occurring or experimental delays can take place. Some are harmless to the offspring, some can prevent fertilization or destroy the conceptus, and some can damage it to a degree consistent with survival but with a congenital defect.Because the reproductive process is itself complex, the different manners and situations in which faulty timing can enter and influence the normal sequence of events are numerous and, on first encounter, surprising in their ramifications. Usually, delays during reproduction have been observed by workers intent on some purpose besides determining the ability of such delays . . .
Abstract 327: Targeting autophagy overcomes enzalutamide resistance in castrate-resistant prostate cancer cells and improves therapeutic response in a xenograft model
Authors: Joy C. Yang, Hao G. Nguyen, Hsing-Jien Kung, Xu-Bao Shi, Derya Tilki, Ralph W. deVere White, Allen C. Gao, Christopher P. Evans
Journal: Cancer Research (2014)

Abstract Androgen deprivation or treatment with the androgen receptor signaling inhibitor (ARSI), Enzalutamide (MDV-3100, ENZA) or biclutamide induces autophagy in androgen-dependent and castration resistant CaP (CRPC) cell lines. This autophagic process is mediated by AMPK activation and the suppression of mTOR through Raptor phosphorylation (Serine 792). Using autophagy modulators such as clomipramine (CMI) or metformin in combination with ENZA drastically reduces the cell survival in the colony formation assay. Metformin in combination with ENZA causes AR degradation, which is inhibited by proteasome inhibitor MG132. Transcriptome deep sequencing of parental and ENZA resistant C4-2B cells was carried out to examine differential gene expression pattern that may be related to their ability to survive under constant high exposure to ARSI. In-vivo studies with mice orthotopically implanted with ENZA resistant cells demonstrates that the combination of ENZA and autophagy modulators, CMI or metformin significantly reduces tumor growth when compared to control groups (p&amp;lt;0.005). Blocking autophagy pharmacologically or genetically significantly impairs prostate cancer cell survival in- vitro and in-vivo, implying the therapeutics potential of autophagy inhibitors in the antiandrogen resistance setting.This work is supported in part by Stand Up To Cancer - Prostate Cancer Foundation–Prostate Dream Team Translational Cancer Research Grant. This research grant is made possible by the generous support of the Movember Foundation. Stand Up To Cancer is a program of the Entertainment Industry Foundation administered by the American Association for Cancer Research. Citation Format: Joy C. Yang, Hao G. Nguyen, Hsing-Jien Kung, Xu-Bao Shi, Derya Tilki, Ralph W. deVere White, Allen C. Gao, Christopher P. Evans. Targeting autophagy overcomes enzalutamide resistance in castrate-resistant prostate cancer cells and improves therapeutic response in a xenograft model. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 327. doi:10.1158/1538-7445.AM2014-327
MRI-Negative, Bone Scintigram-Positive in Early Osteonecrosis of the Knees
Authors: Bruce J. M. Warwick, Vincent Caristo, Nathan Hartin, Wisam Ihsleish, Chandima Perera, Hans Van der Wall
Journal: Clinical Nuclear Medicine (2006)

Nontraumatic avascular necrosis (AVN) of bone is a well-reported complication of glucocorticoid therapy for immunologic and malignant disease. We present the case of a 13-year-old girl with no history of trauma who presented with a 5-day history of increasing pain in both knees after cord blood transplantation for acute lymphoblastic leukemia. Plain film and magnetic resonance imaging (MRI) were reported as normal. Bone scintigraphy revealed evidence of bilateral avascular necrosis in the distal femora. MRI subsequently became abnormal several weeks later. The case illustrates the natural history of AVN, in which changes that are detected by MRI can take several weeks to develop. The scintigraphic findings influenced early management of the condition.
Sinus CT scans and mediator release in nasal secretions after nasal challenge with cypress pollens
Authors: V. Piette, C. Bousquet, V. Kvedariene, H. Dhivert‐Donnadieu, L. Crampette, J.‐P. Senac, J. Bousquet, P. Demoly
Journal: Allergy (2004)

Background: Involvement of paranasal sinuses has been suggested in allergic rhinitis but not clearly demonstrated. Aims: To investigate the relationship between intermittent allergic rhinitis and computerized tomography (CT). Methods: Twenty patients with intermittent rhinitis and sensitized to cypress pollens underwent unilateral nasal provocation tests (NPTs) using increasing concentrations of cypress pollens out of the pollen season. Sinus CT‐scans were carried out just before a NPT and 24 h later. Nasal lavage was carried out just before a NPT, 30 min after a positive challenge and again 24 h later. Leucotriene C4/D4, intracellular adhesion molecule‐1 and eosinophil cationic protein were measured in nasal secretions. Results: Thirteen patients (65%) showed an alteration in their CT‐scans after allergen challenge. Ten of them showed sinus changes controlateral to their allergenic provocation. Radiological changes mainly affected the osteomeatal complex and the ethmoid sinuses. Pre‐existing abnormalities (13 of 20 cases) mainly concerned the maxillary sinuses. There was no correlation between CT‐scan abnormalities and levels of mediators released in nasal secretions. Conclusions: We have shown that nasal allergen challenge can produce radiological changes in the paranasal sinuses. This mainly concerned the ethmoid sinuses.
Evaluation of Pharmacologic Prevention of Pancreatitis After Endoscopic Retrograde Cholangiopancreatography: A Systematic Review
Authors: Nisa M. Kubiliun, Megan A. Adams, Venkata S. Akshintala, Marisa L. Conte, Gregory A. Cote, Peter B. Cotton, Jean-Marc Dumonceau, Grace H. Elta, Evan L. Fogel, Martin L. Freeman, Glen A. Lehman, Mariam Naveed, Joseph Romagnuolo, James M. Scheiman, Stuart Sherman, Vikesh K. Singh, B. Joseph Elmunzer
Journal: Clinical Gastroenterology and Hepatology (2015)
The Choledochoscopic and Histopathological Grading of Choledochitis
Authors: A. Nishimura, H. Otsu, T. Hiura
Journal: Endoscopy (1979)

The choledochoscopic photographs of 91 and 119 patients with cholecystolithiasis and choledocholithiasis respectively were reviewed on the basis of endoscopic grading. By analogy with the system of the grading, the diseases were also divided into four histopathological gradings. Choledochoscopy provides an alternative approach to the diagnosis of choledochitis, which is also corroborated by the histopathological data in calculous diseases.
Acute Myocardial Infarction Complicated by Atrial Fibrillation in the Elderly
Authors: Saif S. Rathore, Alan K. Berger, Kevin P. Weinfurt, Kevin A. Schulman, William J. Oetgen, Bernard J. Gersh, Allen J. Solomon
Journal: Circulation (2000)

Background —Although atrial fibrillation (AF) is a common complication of acute myocardial infarction (MI), patient characteristics and association with outcomes remain poorly defined in the elderly. Methods and Results —We evaluated 106 780 Medicare beneficiaries ≥65 years of age from the Cooperative Cardiovascular Project treated for acute MI between January 1994 and February 1996 to determine the prevalence and prognostic significance of AF complicating acute MI in elderly patients. Patients were categorized on the basis of the presence of AF, and those with AF were further subdivided by time of AF (present on arrival versus developing during hospitalization). AF and non-AF patients were compared by univariate analysis, and logistic regression modeling was used to identify clinical predictors of AF. The influence of AF on outcomes was evaluated by unadjusted Kaplan-Meier survival curves and logistic regression models. AF was documented in 23 565 patients (22.1%): 11 510 presented with AF and 12 055 developed AF during hospitalization. AF patients were older, had more advanced heart failure, and were more likely to have had a prior MI and undergone coronary revascularization. AF patients had poorer outcomes, including higher in-hospital (25.3% versus 16.0%), 30-day (29.3% versus 19.1%), and 1-year (48.3% versus 32.7%) mortality. AF remained an independent predictor of in-hospital (odds ratio [OR], 1.21), 30-day (OR, 1.20), and 1-year (OR, 1.34) mortality after multivariate adjustment. Patients developing AF during hospitalization had a worse prognosis than patients who presented with AF. Conclusions —AF is a common complication of acute MI in elderly patients and independently influences mortality, particularly when it develops during hospitalization.
Urine Proteome Analysis May Allow Noninvasive Differential Diagnosis of Diabetic Nephropathy
Authors: Massimo Papale, Salvatore Di Paolo, Riccardo Magistroni, Olga Lamacchia, Anna Maria Di Palma, Angela De Mattia, Maria Teresa Rocchetti, Luciana Furci, Sonia Pasquali, Salvatore De Cosmo, Mauro Cignarelli, Loreto Gesualdo
Journal: Diabetes Care (2010)

OBJECTIVE Chronic renal insufficiency and/or proteinuria in type 2 diabetes may stem from chronic renal diseases (CKD) other than classic diabetic nephropathy in more than one-third of patients. We interrogated urine proteomic profiles generated by surface-enhanced laser desorption/ionization-time of flight/mass spectrometry with the aim of isolating a set of biomarkers able to reliably identify biopsy-proven diabetic nephropathy and to establish a stringent correlation with the different patterns of renal injury. RESEARCH DESIGN AND METHODS Ten micrograms of urine proteins from 190 subjects (20 healthy subjects, 20 normoalbuminuric, and 18 microalbuminuric diabetic patients and 132 patients with biopsy-proven nephropathy: 65 diabetic nephropathy, 10 diabetic with nondiabetic CKD [nd-CKD], and 57 nondiabetic with CKD) were run using a CM10 ProteinChip array and analyzed by supervised learning methods (Classification and Regression Tree analysis). RESULTS The classification model correctly identified 75% of patients with normoalbuminuria, 87.5% of those with microalbuminuria, and 87.5% of those with diabetic nephropathy when applied to a blinded testing set. Most importantly, it was able to reliably differentiate diabetic nephropathy from nd-CKD in both diabetic and nondiabetic patients. Among the best predictors of the classification model, we identified and validated two proteins, ubiquitin and β2-microglobulin. CONCLUSIONS Our data suggest the presence of a specific urine proteomic signature able to reliably identify type 2 diabetic patients with diabetic glomerulosclerosis.
Nondialytic Management of Chronic Uremia
Authors: Eugene L. Coodley
Journal: JAMA (1973)

We evaluated salt loading alone and in conjunction with diuretic therapy in the management of chronic renal disease with azotemia. Ten patients with chronic renal disease and azotemia were treated with progressively increasing doses of sodium and potent, distal tubular diuretic agents, ie, furosemide or ethacrynic acid or both. Hydrochlorothiazide was also employed in these patients. Six of the ten patients responded with an adequate diuresis of more than 2,200 ml/24 hr, a fall in blood urea nitrogen level, and an alleviation of uremic symptoms with an average dose of 6 gm of added sodium, on a basal 2-gm sodium diet. In four patients, salt loading was unsuccessful; two of these patients had creatinine clearance values of less than 7 ml/min.
Pharmacokinetics, biocompatibility and bioavailability of a controlled release monoclonal antibody formulation
Authors: Daniel Schweizer, Igor Vostiar, Annabelle Heier, Tim Serno, Karin Schoenhammer, Michael Jahn, Stewart Jones, Aline Piequet, Christian Beerli, Hermann Gram, Achim Goepferich
Journal: Journal of Controlled Release (2013)
346 INCREASED LIVER EXPRESSION OF INFLAMMATORY MEDIATORS IS ASSOCIATED WITH HEPATIC INSULIN RESISTANCE IN LEAN, NON-DIABETIC PATIENTS WITH CHRONIC HEPATITIS C
Authors: E. Vanni, M.L. Abate, E. Gentilcore, C. Elia, R. Gambino, M. Cassader, A. Smedile, M. Rizzetto, G. Marchesini, A. Gastaldelli, E. Bugianesi
Journal: Journal of Hepatology (2009)
Antibody that blocks stimulation of cortisol secretion by adrenocorticotrophic hormone in Addison's disease
Authors: P. Kendall-Taylor, A. Lambert, R. Mitchell, W. R Robertson
Journal: BMJ (1988)

To investigate whether Addison9s disease may in some cases be due to the blocking of adrenocorticotrophic hormone9s action at the adrenal cortex by antibodies IgG isolated from a woman with Addison9s disease associated with the autoimmune polyglandular syndrome type I was studied. Its effects on guinea pig adrenal cells in vitro were investigated and compared with those of IgG from three normal subjects and IgG obtained commercially. IgG from the patient inhibited the stimulation of cortisol secretion by adrenocorticotrophic hormone by 77 (SD 2)% and 57 (12)% at concentrations of 0·5 and 0·05 g/l, respectively; IgG prepared five months after she had started treatment with replacement steroids inhibited cortisol secretion by 74 (1)% (0·5 g/l) and 51 (15)% (0·05 g/l). The other IgGs had no inhibitory effects. The IgG from the patient and that obtained commercially did not inhibit the stimulation of cortisol secretion by dibutyryl cyclic adenosine monophosphate or precursors of cortisol. None of the IgGs bound to adrenocorticotrophic hormone. These results suggest that the IgG from the patient acted against the receptor for adrenocorticotrophic hormone, and its presence may explain the patient9s raised concentrations of adrenocorticotrophic hormone, failure to respond to exogenous adrenocorticotrophic hormone, and normal basal cortisol concentrations. Addison9s disease may thus in some instances be a receptor antibody disease.
In acute calculous cholecystitis, antibiotics after cholecystectomy did not reduce infection
Authors: Daniel I. Steinberg
Journal: Annals of Internal Medicine (2014)

Source Citation Regimbeau JM, Fuks D, Pautrat K, et al; FRENCH Study Group. Effect of postoperative antibiotic administration on postoperative infection following cholecystectomy for acute calculous cholecystitis: a randomized clinical trial. JAMA. 2014;312:145-54. 25005651
Effects of Statins on Nonlipid Serum Markers Associated with Cardiovascular Disease
Authors: Ethan M. Balk, Joseph Lau, Leonidas C. Goudas, Harmon S. Jordan, Bruce Kupelnick, Linda U. Kim, Richard H. Karas
Journal: Annals of Internal Medicine (2003)

Background: Statins reduce cardiovascular events to a greater extent than can be explained by their effect on lipids. Several studies have attempted to elucidate mechanisms by which statins reduce cardiovascular risk. Purpose: To summarize the effects of statins on nonlipid serum markers and to correlate statins' effect on serum markers with lipid levels and cardiovascular outcomes. Data Sources: MEDLINE (1980 to 2003) search limited to English-language articles. Study Selection: Studies reporting original data in at least 10 participants on the effect of statins on outcomes of interest, excluding studies of cerivastatin, drug combinations, and patients with organ transplants. Data Extraction: Study design, sample size, treatment, and outcome data extracted on the basis of preestablished criteria. When appropriate, meta-analysis was performed by using a random-effects model. Data Synthesis: All statins are effective at lowering C-reactive protein levels, and the effect is not dose-dependent. Studies do not demonstrate a correlation between statins' effects on C-reactive protein levels and on lipids or cardiovascular outcomes. Statins do not affect fibrinogen levels, and limited data suggest little effect on lipid oxidation, tissue plasminogen activator, or plasminogen activator inhibitor. Platelet aggregation data are inconclusive. Conclusions: Among nonlipid serum markers examined, only C-reactive protein levels are statistically significantly affected by statins. These findings suggest that statin-mediated anti-inflammatory effects may contribute to the ability of statins to reduce risk for cardiovascular disease. Overall, however, available data are insufficient to support recommendations for using nonlipid serum markers in decisions regarding statin therapy for individual patients.