tbuckley/cabot-search huggingface dataset:
PtdIns3P and Rac direct the assembly of the NADPH oxidase on a novel, pre-phagosomal compartment during FcR-mediated phagocytosis in primary mouse neutrophils
Authors: Karen E. Anderson, Tamara A. M. Chessa, Keith Davidson, Robert B. Henderson, Simon Walker, Tanya Tolmachova, Katarzyna Grys, Oliver Rausch, Miguel C. Seabra, Victor L. J. Tybulewicz, Len R. Stephens, Phillip T. Hawkins
Journal: Blood (2010)
Matrix metalloproteinase-7–dependent release of tumor necrosis factor-α in a model of herniated disc resorption
Authors: Hirotaka Haro, Howard C. Crawford, Barbara Fingleton, Kenichi Shinomiya, Dan M. Spengler, Lynn M. Matrisian
Journal: Journal of Clinical Investigation (2000)

Herniated disc (HD), one of the major causes of low back pain, is often resolved spontaneously without surgical intervention. Resorption is associated with a marked increase in infiltrating macrophages, and the matrix metalloproteinases (MMP) MMP-3 and MMP-7 have been implicated in this phenomenon. We developed a murine organ culture model in which intact intervertebral discs were cocultured with peritoneal macrophages to investigate the role of MMPs in HD resorption. Using macrophages isolated from MMP-null mice, we report that macrophage-produced MMP-7 was required for proteoglycan degradation, loss of wet weight, and macrophage infiltration of cocultured discs. The inability of MMP-7–deficient macrophages to infiltrate discs could not be attributed to a defect in macrophage migration. MMP-7 was required for the release of the cytokine TNF-α from peritoneal macrophages. The generation of soluble TNF-α was essential for the induction of MMP-3 in disc cocultures, which in turn is required for the generation of a macrophage chemoattractant and subsequent macrophage infiltration. TNF-α release from macrophages was necessary but insufficient for disc resorption, which required macrophage infiltration. We conclude that there is extensive communication between macrophages and chondrocytes in HD resorption and that an essential component of this communication is the requirement for MMPs to release soluble bioactive factors.
Renal function and urate metabolism in late survivors with cyanotic congenital heart disease.
Authors: E A Ross, J K Perloff, G M Danovitch, J S Child, M M Canobbio
Journal: Circulation (1986)

Diminished glomerular filtration rate, proteinuria, and large hypercellular congested glomeruli with segmental sclerosis are found in late survivors with cyanotic congenital heart disease (CCHD). Hyperuricemia is common, acute gouty arthritis is less common than uric acid levels would predict, and overt tophaceous deposits of uric acid are exceptional. The role of the kidney in causing the basic biochemical disturbances, and the relative importance of impaired urate excretion vs urate overproduction have not been established. Accordingly, we reviewed the courses of two index patients and prospectively studied eight additional CCHD patients from 28 years to 46 years old with mean hematocrits of (62 +/- 10%). Plasma creatinine concentration was normal (0.9 +/- 0.1 mg/dl) yet glomerular filtration rate was mildly reduced to 93 +/- 14 ml/min as measured by creatinine clearance and to 81 +/- 6 ml/min as measured by 111In DTPA. Three patients had significant proteinuria and one was nephrotic. Plasma uric acid concentration was high in all but one (8.2 +/- 2.1 mg/dl), mean 24 hr uric acid excretion was normal (564 +/- 221 mg), and fractional uric acid excretion was relatively low (6.3 +/- 2.6%). The two patients with highest plasma uric acid levels (12.0 and 10.2 mg/dl) had the lowest fractional excretions (2.8% and 4.0%). Both of these patients had diminished capacity to excrete a water load (38% and 27%/4 hr) and to maximally concentrate urine (520 and 635 mOsm/kg after water deprivation and vasopressin). In conclusion, high plasma uric acid levels in late survivors with CCHD are secondary to inappropriately low fractional uric acid excretion, not to urate overproduction.(ABSTRACT TRUNCATED AT 250 WORDS)
Dentin Matrix Protein 1 Enhances Invasion Potential of Colon Cancer Cells by Bridging Matrix Metalloproteinase-9 to Integrins and CD44
Authors: Abdullah Karadag, Neal S. Fedarko, Larry W. Fisher
Journal: Cancer Research (2005)

Abstract The up-regulation of various matrix metalloproteinases (MMP), certain cell receptors such as integrins and CD44, and the SIBLING family of integrin-binding glycophosphoproteins have been reported separately and in various combinations for many types of tumors. The mechanisms by which these different proteins may be interacting and enhancing the ability of a cancer cell to survive and metastasize have become an interesting issue in cancer biology. Dentin matrix protein 1 (DMP1) has been known for a number of years to bind to CD44 and ArgGlyAsp sequence–dependent integrins. This SIBLING was recently shown to be able to specifically bind and activate proMMP-9 and to make MMP-9 much less sensitive to inhibition by tissue inhibitors of metalloproteinases and synthetic inhibitors. In this study, we used a modified Boyden chamber assay to show that DMP1 enhanced the invasiveness of the MMP-9 expressing colon cancer cell line, SW480, through Matrigel in a dose-dependant manner. DMP1 (100 nmol/L) increased invasion 4-fold over controls (86.1 ± 13.9 versus 22.3 ± 9.8, P &amp;lt; 0.001). The enhanced invasive potential required the presence of MMP-9 and at least one of the cell surface receptors, CD44, αvβ3, or αvβ5 integrin. The bridging of MMP-9 to the cell surface receptors was shown by both pull-down and fluorescence activated cell sorting experiments. Because all of these proteins were also shown by immunohistochemistry to be expressed in serial sections of a colon adenocarcinoma, we have hypothesized that the MMP-9/DMP1/cell surface complexes observed to enhance cell invasion in vitro may be aiding metastatic events in vivo. (Cancer Res 2005; 65(24): 11545-52)
Search for the Complication
Authors: Francis Salamon, Rafael Hirsch, Ran Tur-Kaspa, Mordechai R. Kramer
Journal: New England Journal of Medicine (2006)

A 58-year-old woman was hospitalized for evaluation of prolonged fever and hemoptysis. She reported having had intermittent fevers, a productive cough, shortness of breath, and hemoptysis during the previous eight months, which had been evaluated at another hospital. Computed tomography of the chest revealed peripheral infiltrates in the upper lobe of the left lung and lingula and a calcified left hilar opacity, with additional, small mediastinal lymph nodes.
Over-the-Counter Naproxen Sodium and Esophageal Injury
Authors: Laura H. Kahn
Journal: Annals of Internal Medicine (1997)

Letters15 June 1997Over-the-Counter Naproxen Sodium and Esophageal InjuryLaura H. Kahn, MD, MPH, Min Chen, MS, RPh, and Robert Eaton, RPhLaura H. Kahn, MD, MPHU.S. Food and Drug Administration, Rockville, MD 20857Search for more papers by this author, Min Chen, MS, RPhU.S. Food and Drug Administration, Rockville, MD 20857Search for more papers by this author, and Robert Eaton, RPhU.S. Food and Drug Administration, Rockville, MD 20857Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-126-12-199706150-00032 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We report a case series involving predominantly young, healthy persons who developed esophageal problems after consuming over-the-counter naproxen sodium. This drug (at a dose of 220 mg) was approved for marketing in January 1994. The U.S. Food and Drug Administration's Spontaneous Reporting System received 81 reports of esophageal symptoms occurring with the drug; these cases made up approximately 1% of all reports for over-the-counter naproxen sodium received through December 1995.The mean patient age in our series was 35.9 years, and 65 patients (80%) were women. Intake of the tablet (as opposed to the caplet) form was ...References1. Marvola M, Rajaniemi M, Marttila E, Yahervuo K, Sothmann A. Effect of dosage form and formulation factors on the adherence of drugs to the esophagus. J Pharm Sci. 1983; 72:1034-6. Google Scholar2. Kikendall JW. Pill-induced esophageal injury. Gastroenterol Clin North Am. 1991; 20:835-6. Google Scholar Author, Article, and Disclosure InformationAuthors: Laura H. Kahn, MD, MPH; Min Chen, MS, RPh; Robert Eaton, RPhAffiliations: U.S. Food and Drug Administration, Rockville, MD 20857Disclaimer: Opinions and assertions contained herein are those of the authors and are not to be construed as representing those of the U.S. Food and Drug Administration. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMedication‐Induced Esophageal InjuryNaproxen and piproxenPill‐Induced Esophageal InjuryEsophageal Disorders Caused by Medications, Trauma, and InfectionDrug-Induced Esophageal Injuries and DysphagiaSubsequent Loss of The Proliferated Bile Ductules in Fulminant Hepatitis in Childhood—Isnʼt It Caused by Apoptosis?Saure antipyretische AnalgetikaNSAIDs, Aspirin, and Esophageal StricturesPill EsophagitisAnti-inflammatory and antipyretic analgesics and drugs used in gout 15 June 1997Volume 126, Issue 12Page: 1006KeywordsAntiviralsCase seriesDrugsEndoscopyFood and Drug AdministrationHemorrhageIbuprofenPharynxSodiumUlcers ePublished: 15 August 2000 Issue Published: 15 June 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Doctors Afield and Afloat
Authors: Hugh P. Greeley
Journal: New England Journal of Medicine (1958)

IN January, 1813, "more for a frolic than for anything serious," a young man of Massachusetts quitted his father's house of "ease and plenty, to make a short trip in a Privateer," being very little concerned whether captured or not, since being taken prisoner would carry him "among the people whom I had long adored for their superior bravery, magnanimity, religion, knowledge, and justice." These opinions "I had imbibed from their own writers, in verse and prose. Beside the federal newspapers, I had dipped into the posthumous works of Fisher Ames, enough to inspire me with adoration of England, abhorrence . . .
Inaccuracies in measuring tourniquet pressures.
Authors: J Hallett
Journal: BMJ (1983)

Since Roman times the surgical tourniquet has been used to arrest blood flow in a limb.' Initially they were applied to stop severe haemorrhage either due to injury or as a result of emergency amputation.Since the middle of the nineteenth century they have been used during elective surgery.Any fault in the gauge measuring the pressure of the inflatable cuff may cause problems.Firstly, too low a reading may result in excessive pressure on the limb and cause local tissue damage or nerve palsies.Secondly, too high a reading may allow blood to flow into the wound-so increasing the difficulties of the surgical procedure-and, in the case of intravenous regional analgesia, allow a large bolus of local anaesthetic to enter the circulation.2The commonest gauge in use in operating theatres is of the Bourdon type (figure).They are accurate and robust, but unlike a mercury manometer it is not immediately obvious if they are damaged or have become inaccurate.For this reason they must be tested regularly,4 8 as recommended by the manufacturers.Realising that I had never seen a tourniquet gauge checked or Flattened tube in 250 degree arc Pressure to be measu red I'ype ot gauge commonly used with surgical measure the pressure of the inflatable cuff.tourniquet equipment to
Priapism in a patient with unstable hemoglobin: Hemoglobin Köln
Authors: Valérie Andrieu, Olivier Dumonceau, Marie‐José Grange
Journal: American Journal of Hematology (2003)

Abstract We report a case of severe priapism occurring in a patient with unstable hemoglobin, hemoglobin Köln, and underline several factors that may have contributed to this complication: abnormal plasticity of red cells, splenectomy, and cytomegalovirus infection. Since emergency treatment may prevent impotence, patients and parents should be educated about this complication. Am. J. Hematol. 74:73–74, 2003. © 2003 Wiley‐Liss, Inc.
Treatment IND' Is an Oxymoron
Authors: Eugene J. Segre
Journal: JAMA (1988)

To The Editor.  —An article 1 in the Dec 11 issue of JAMA emphasized patients' safety and payment for drugs as major issues in the implementation of the   (use of investigational new drugs [INDs] to treat patients with serious or immediately life-threatening illnesses). Making promising new therapies available to the desperately ill is a worthy goal.  Ms Monaco and Ms Gottlieb indicate that only time will tell whether the treatment IND will achieve this goal or only subvert the clinical trial process so that drug efficacy can never be adequately demonstrated. I believe that is a critical issue. If patients have the option of either buying experimental drugs under a treatment IND or entering a clinical trial where they don't pay but perhaps have a 50% chance of receiving an investigational drug and a 50% chance of receiving a placebo, will their consent for the trial be forthcoming?
Attempted suicides from intact and broken parental homes.
Authors: S. Greer, J. C. Gunn
Journal: BMJ (1966)

Attempted Suicide-Greer et al.MEDICALISHRNAl 1355 predispose to disruption of interpersonal relationships, and (2) this childhood experience may make individuals abnormally vulnerable to the loss of a loved person in later life, thus precipitating suicidal reactions.These tentative propositions, and the findings upon which they are based, obviously require verification.If confirmed, they raise a number of fundamental questions concerning the psychological mechanisms whereby parental loss contributes to the disruption of interpersonal relations and sensitizes certain individuals to this situation.Clearly, further research in this area is indicated. SummaryA consecutive series of 156 attempted suicides admitted to hospital were compared with (1) non-suicidal psychiatric patients and (2) medical, surgical, and obstetric patients with- out psychiatric disorder in respect of salient variables in their past and present environment.Controls were matched with attempted suicides for age, sex, social class, country of origin, and, in the case of psychiatric patients, diagnosis.Attempted suicides differed significantly from both control groups in having a greater incidence of childhood parental loss, and such loss more commonly involved both parents, occurred at a younger age, and was more likely to be permanent (i.e., due to parental death and divorce).The sex of the absent parent and the childhood environment after parental loss were not correlated with attempted suicide.With regard to the immediate environment, a significantly higher proportion of attempted suicides than controls had experienced recent disruption of a close relationship due to interpersonal conflict.No significant differences were observed between the suicidal and control groups in terms of (a) social isolation (i.e., living alone), (b) psychological isolation (i.e., the absence of any close interpersonal relationships), (c) material circumstances, or (d) physical illness.Recent disruption of close relationships was found to be correlated with parental loss.Possible ways in which these variables may contribute to suicidal behaviour are considered.The need for verification of present findings is stressed.The same study is being conducted on an American hospital population by other workers, and their findings are awaited with interest.We are grateful to Professor J. Anderson, medical unit, and Dr. D.
Conduction and Automaticity in Rat Myocardium
Authors: Grattan C. Woodson, Walter Lyon Bloom
Journal: Circulation Research (1966)

Intraventricular infusion of isotonic potassium chloride solution showed that blocking conduction in the subendocardial tissues of a single ventricle drastically alters normal conduction, with ensuing impulses being transmitted from the opposing ventricle. Blocking the endocardial tissues of both ventricles produces asystole even though the myocardium is capable of contracting as demonstrated by its contractile response to mechanical and electrical stimuli. These observations lend support to the concept that automaticity is a property confined to the specialized tissues of the conduction system.
Race and the Limits of Administrative Data
Authors: David H. Mark
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A-8103 in Polycythemia
Authors: Raymond W. Monto, Andrew TenPas, John D. Battle, Robert J. Rohn, John Louis, N. B. Louis
Journal: JAMA (1964)

COMPOUND 8103-Abbott (A-8103), a neutral amide of piperazine (NSC-25154), 1, 4-bis (3-bromopropronyl) piperazine, was shown to have a favorable effect upon neoplastic disease including polycythemia rubra vera by Bond et al in 1962.<sup>1</sup>The antitumor properties of the neutral amide were first demonstrated in transplanted adenocarcinoma, Ca 755 in mice, and spontaneous breast adenocarcinoma in rats.<sup>2-4</sup>Later this agent was shown to be active in chronic granulocytic leukemia and metastatic epithelial malignancies.<sup>5,6</sup>At present, the mechanism of action for A-8103 is not shown. Its chemical structure suggests that it is an alkylating agent. Hematopoietic suppression was noted during initial Phase I and Phase II studies. Subsequently, Bond and Rohn observed a 94% response in patients with polycythemia vera who were refractory to radioactive phosphorus and alkylating agents.<sup>7</sup>These favorable preliminary results stimulated the present study by the Midwest Cooperative Chemotherapy Group. <h3>Materials and Methods</h3><h3>Diagnosis.—</h3> The minimum
Lack of effect of hypercapnic acidosis on elasticity of cat papillary muscles
Authors: A. R. MATTIAZZI, H. E. CINGOLANI, T. P. GRAHAM
Journal: Cardiovascular Research (1977)

Chages in external pH from 7.40 to 6.95 obtained by changing the pCO2 of the medium at constant bicarbonate concentration produced in cat papillary muscles a significant decrease in isometric tension with no changes in time to peak tension. Active and resting stiffness, as determined by two different methods, did not change under conditions of hypercapnic acidosis.
Depth of Remission is a Prognostic Factor for Survival in Patients with Metastatic Renal Cell Carcinoma
Authors: Viktor Grünwald, Rana R. McKay, Katherine M. Krajewski, Daniel Kalanovic, Xun Lin, Julia J. Perkins, Ronit Simantov, Toni K. Choueiri
Journal: European Urology (2015)
TRUE (IDIOPATHIC) ANGINA PECTORIS. ITS ETIOLOGY, PATHOLOGY AND THERAPEUTICS.
Authors: THOS. L. MADDIN
Journal: JAMA (1897)

<h3>Case 1.</h3> —Mr. E., a merchant from early manhood, habits excellent, possessed of a fine constitution, never seriously sick, 60 years of age, consulted me in reference to a severe paroxysmal itching in his arms, vertigo, and torpid liver; these discomforts yielded to a simple line of treatment addressed to his liver, viz., frugality both in reference to the quantity and quality of his food, and much time in the open air. A few months afterward I was called to see him, in the early hours of the morning, on account of a severe and sudden paroxysm of bronchial and cardiac asthma. I found him almost cyanotic, with the most characteristic symptoms of asthma, and a scarcely perceptible and irregular pulse. The symptoms yielded readily after a hypodermic of morphia one-third gr. and atropia one hundred and twentieth gr. This was his first asthmatic paroxysm and there was no history
Subluxing arthropathy: an unusual manifestation of the antisynthetase syndrome
Authors: O Meyer, H Charlanne, P Cherin, Y Allanore, P Coquerelle, B Grardel, A-M Chamot, E Hachulla
Journal: Annals of the Rheumatic Diseases (2008)

Antisynthetase syndrome was first described by Marguerie et al as a combination of polymyositis (or at least creatine kinase elevation), diffuse interstitial lung disease and autoantibodies to t-RNA synthetase.1

Joint signs and symptoms occur in up to 90% of patients with polymyositis or dermatomyositis2 and/or antisynthetase syndrome, occasionally as the initial manifestations. They include arthralgia, polyarthritis and deforming arthropathy with subluxation.

To establish a multicentre registry of patients with joint manifestations of antisynthetase syndrome, a standardised form was posted on the CRI (Club Rhumatismes et Inflammation) website (http://www.cri-net.com), which is part of the French Society for Rheumatology, with the partnership of the French Society of Internal Medicine.

During a …
A Federal Health Service Corps
Authors: Blake W. H. Smith, Roy J. Gerard
Journal: New England Journal of Medicine (1982)

The National Health Service Corps (NHSC) scholarship program is a moribund child. The month of its death is predictable. In June of 1985 the small group of medical students who obtained NHSC scholarships as first-year students in 1981 will graduate — barring a few stragglers and dropouts — and the National Health Service Corps scholarship program will expire at the age of 11 years.Only a handful of medical students obtained new NHSC scholarships this year. Being in exceptional financial need, they qualified for a last burst of new scholarships issued with unspent funds carried over from the previous fiscal . . .
Women Doctors in the N.H.S
Authors: N. K. Shrubshall
Journal: BMJ (1975)

A 36-year-old woman presented with eye pain and blurring of vision in her right eye. On eye examination, it was noted that there were angle-closure glaucoma and anterior uveitis in both eyes. Ocular ultrasound showed short axial lengths as well as a choroidal thickening in both eyes, confirming the diagnosis of nanophthalmos. Nanophthalmos is a condition where the eye is abnormally short, resulting in axial hyperopia and predisposing it to angle-closure glaucoma. The patient was initially managed medically, but the glaucoma was intractable. The patient underwent repeated sessions of transscleral cyclophotocoagulation which eventually lowered the intraocular pressure. The management of nanophthalmic eyes can be quite challenging due to the risk of inciting uveal effusion syndrome with any form of intraocular surgery. Controlled and repeated sessions of transscleral cyclophotocoagulation may be considered as a viable management option in these cases.