A New Acid-Base Nomogram Featuring Hydrogen Ion Concentration
Authors: JORDAN J. COHEN
Journal: Annals of Internal Medicine (1967)

Diagnosis and Treatment1 January 1967A New Acid-Base Nomogram Featuring Hydrogen Ion ConcentrationHenderson RevisitedJORDAN J. COHEN, M.D.JORDAN J. COHEN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-1-159 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFor years acid-base nomograms have assisted students in their struggle to understand the regulation of extracellular acidity. By providing a means for visualizing the physiologic permutations of the carbonic acid-bicarbonate buffer pair, nomograms have simplified the description of this crucial, biologic regulatory system. All of the popular nomograms, however, including those of Shock and Hastings (1), Singer and Hastings (2), Davenport (3), and Siggaard-Andersen (4), have depicted acidity in the conventional units of pH and, therefore, have been wedded to the rather complicated mathematics of the Henderson-Hasselbalch equation (see below). The purpose of the present communication is to describe a...References1. SHOCKHASTINGS NWAB: Studies of acid-base balance of blood. IV. Characterization and interpretation of displacement of acid-base balance. J. Biol. Chem. 112: 239, 1935. CrossrefGoogle Scholar2. SINGERHASTINGS RBAB: An improved clinical method for the estimation of disturbances of the acid-base balance of human blood. Medicine (Balt.) 27: 223, 1948. CrossrefMedlineGoogle Scholar3. DAVENPORT HW: The ABC of Acid-base Chemistry, 4th ed. University of Chicago Press, Chicago, 1958. Google Scholar4. SIGGAARD-ANDERSEN O: The pH-log pCO2 blood acid-base nomogram revised. Scand. J. Clin. Lab. Invest. 14: 598, 1962. CrossrefMedlineGoogle Scholar5. HENDERSON LJ: The theory of neutrality regulation in the animal organism. Amer. J. Physiol. 21: 427, 1908. CrossrefGoogle Scholar6. HUCKABEE WE: Henderson vs. Hasselbalch. Clin. Res. 9: 116, 1961. Google Scholar7. CAMPBELL EJ: RIpH. Lancet 1: 681, 1962. CrossrefMedlineGoogle Scholar8. HASSELBALCH KA: Die Berechnung der Wasserstoffzahl des Blutes aus der freien und gebundenen Kohlensäure desselben, und die Sauerstoffbindung des Blutes als Funktion der Wasserstoffzahl. Biochem. Z. 78: 112, 1917. Google Scholar9. BRACKETTCOHENSCHWARTZ NCJJWB: Carbon dioxide titration curve of normal man. Effect of increasing degrees of acute hypercapnia on acid-base equlibrium. New Eng. J. Med. 272: 6, 1965. CrossrefMedlineGoogle Scholar10. SCHWARTZBRACKETTCOHEN WBNCJJ: The response of extracellular hydrogen ion concentration to graded degrees of chronic hypercapnia: the physiologic limits of the defense of pH. J. Clin. Invest. 44: 291, 1965. CrossrefMedlineGoogle Scholar11. WINTERSLOWDERORDWAY RWJANK: Observation on carbon dioxide tension during recovery from metabolic acidosis. J. Clin. Invest. 37: 640, 1958. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Providence, Rhode IslandFrom the Division of Biological and Medical Sciences, Brown University, and the Department of Medicine, Rhode Island Hospital, Providence, R. I.Requests for reprints should be addressed to Jordan J. Cohen, M.D., 593 Eddy St., Providence, R. I. 02903. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited By“Won't Breathe” vs “Can't Breathe”A Diagram to Facilitate the Understanding and Therapy of Mixed Acid Base DisordersACID-BASE DIAGRAMS MATHS, MYTHS, AND MEASUREMENTSThe usefulness of non-respiratory hydrogen ion concentration and its relationship to the traditional acid-base parametersBicarbonate and Chloride Shifts in Rat Brain During Acute and Prolonged Respiratory Acid-Base Changes 1 January 1967Volume 66, Issue 1Page: 159-164KeywordsAttentionBicarbonatesBiologicsHospital medicineShockSystems biology Issue Published: 1 January 1967 PDF DownloadLoading ...