Studies of Monoclonal Immunoglobulins (M-Components) in Various Kindreds
Authors: RALPH C. WILLIAMS
Journal: Annals of Internal Medicine (1967)

Article1 August 1967Studies of Monoclonal Immunoglobulins (M-Components) in Various KindredsRALPH C. WILLIAMS JR., M.D., JEFFREY L. ERICKSON, B.A., HERBERT F. POLESKY, M.D., WILLIAM R. SWAIM, M.D.RALPH C. WILLIAMS JR., M.D.Search for more papers by this author, JEFFREY L. ERICKSON, B.A.Search for more papers by this author, HERBERT F. POLESKY, M.D.Search for more papers by this author, WILLIAM R. SWAIM, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-2-309 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe occurrence of electrophoretically sharp, homogeneous serum proteins related to one of the immunoglobulin classes γG, γA, or γM (1) has generally been connected in the minds of clinicians with the distinct entities of multiple myeloma or Waldenström's macroglobulinemia. That such unique sharply defined proteins, termed M-components (2-4), are products of a presumably uniform or monoclonal cell population has been the concept generally held (5). It is also apparent that M-components may occur in association with diverse pathologic states, many neoplastic but others not directly associated with a malignant process (3, 5-11). In some instances M-components have been described in...References1. CEPPELLINIDRAYEDELMANFAHEYFRANEKFRANKLINGOODMANGRABARGURVICHHEREMANSISLIKERKARUSHPRESSTRNKA RSGJFEHCPAEJFHFEZ: Nomenclature for human immunoglobulins. Bull. WHO 30: 447, 1964. MedlineGoogle Scholar2. RIVA G: Das Serumeiweissbild. Hans Huber, Bern, 1957, p. 295. Google Scholar3. WALDENSTRÖM J: Studies on conditions associated with disturbed gamma globulin formation (gammopathies). Harvey Lect. 56: 211, 1961. Google Scholar4. 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Scand. 179 (suppl. 445): 74, 1966. Google Scholar65. WOLLHEIMWILLIAMS FARC: Immunoglobulin studies in six kindreds of patients with adult hypogammaglobulinemia. J. Lab. Clin. Med. 66: 433, 1965. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Minneapolis, MinnesotaFrom the Department of Medicine, University Hospitals, War Memorial Blood Bank, and Minneapolis Veterans Administration Hospital, Minneapolis, Minn.This study was supported by grant 5 T1 AM 5461-03, U. S. Public Health Service, Washington, D. C., and by a grant from the Minnesota Arthritis Foundation, Minneapolis, Minn.Requests for reprints should be addressed to Ralph C. Williams, Jr., M.D., Box 91, University Hospitals, Minneapolis, Minn. 55455. 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FRAUMENI JR., M.D., F.A.C.P., CHARLES L. VOGEL, M.D., VINCENT T. DEVITA, M.D.Rheumatoid Factors in Subacute Bacterial Endocarditis—Bacterium, Duration of Disease or Genetic Predisposition?RONALD P. MESSNER, M.D., THROSTUR LAXDAL, M.D., PAUL G. QUIE, M.D., RALPH C. WILLIAMS JR., M.D. 1 August 1967Volume 67, Issue 2Page: 309-327KeywordsArthritisBlood banksHospital medicineMedical servicesMultiple myelomaProteinsSerum proteins Issue Published: 1 August 1967 PDF DownloadLoading ...