tbuckley/cabot-search huggingface dataset:
Screening for Abdominal Aortic Aneurysm
Authors: Ahmad K. Rahal, Ayesha Z. Zuberi, Robert G. Badgett
Journal: Annals of Internal Medicine (2015)

Letters3 February 2015Screening for Abdominal Aortic AneurysmAhmad K. Rahal, MD, Ayesha Z. Zuberi, MD, and Robert G. Badgett, MDAhmad K. Rahal, MDFrom Kansas University School of Medicine, Wichita, Kansas.Search for more papers by this author, Ayesha Z. Zuberi, MDFrom Kansas University School of Medicine, Wichita, Kansas.Search for more papers by this author, and Robert G. Badgett, MDFrom Kansas University School of Medicine, Wichita, Kansas.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L15-5048 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The updated U.S. Preventive Services Task Force guideline (1) recommends screening for abdominal aortic aneurysm (AAA) in men aged 65 to 75 years who have ever smoked (1). In designing the screening process in our internal medicine clinic, we speculated whether Gawande's observation of the frequent use of computed tomography in a representative community warranted querying regional health care providers for existing abdominal imaging before screening for AAA (2). This query could reduce the cost of mass screening.To assess the prevalence of existing imaging that would qualify as screening, we reviewed our clinic's electronic health records ...References1. LeFevre ML; U.S. Preventive Services Task Force. Screening for abdominal aortic aneurysm: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med. 2014;161:281-90. [PMID: 24957320] doi:10.7326/M14-1204 LinkGoogle Scholar2. Gawande A. How do we heal medicine? Presented at TED2012, Long Beach, California, 27 February–2 March 2012. Session no. 3. Accessed at www.ted.com/talks/atul_gawande_how_do_we_heal_medicine on 11 July 2014. Google Scholar Author, Article, and Disclosure InformationAffiliations: From Kansas University School of Medicine, Wichita, Kansas.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L14-0473. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoScreening for Abdominal Aortic Aneurysm: U.S. Preventive Services Task Force Recommendation Statement Michael L. LeFevre and Screening for Abdominal Aortic Aneurysm: U.S. Preventive Services Task Force Recommendation Statement Michael L. LeFevre and Metrics 3 February 2015Volume 162, Issue 3Page: 238KeywordsAortaComputed axial tomographyDisclosureElectronic medical recordsMagnetic resonance imagingRadiologistsRisk managementScreening guidelinesUltrasound imaging ePublished: 3 February 2015 Issue Published: 3 February 2015 CopyrightCopyright © 2015 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Functional β-adrenergic receptor signalling on nuclear membranes in adult rat and mouse ventricular cardiomyocytes
Authors: B BOIVIN, C LAVOIE, G VANIOTIS, A BARAGLI, L VILLENEUVE, N ETHIER, P TRIEU, B ALLEN, T HEBERT
Journal: Cardiovascular Research (2006)

We sought to determine if different beta-adrenergic receptor (betaAR) subtypes, and their associated signalling machinery, are functionally localized to nuclear membranes.Employing enriched nuclear preparations, we assayed the specific presence of betaAR by measuring 125I-cyanopindolol (CYP) binding, Western blotting, confocal microscopy and functional assays.Western blots of rat heart nuclear fractions and confocal immunofluorescent analysis of adult rat and mouse ventricular cardiomyocytes displayed the presence of beta 1AR and beta 3AR but, surprisingly, not the beta 2AR on nuclear membranes. Nuclear localization of downstream signalling partners Gs, Gi and adenylyl cyclases II and V/VI was also demonstrated. The functional relevance of nuclear betaAR was shown by receptor-mediated stimulation of adenylyl cyclase activity by isoproterenol but not the beta 3AR-selective agonist CL 316243 in enriched nuclear preparations. We also examined the effect of subtype-selective ligands on the initiation of RNA synthesis in isolated nuclei. Both isoproterenol and another beta 3AR-selective agonist, BRL 37344, increased RNA synthesis which was inhibited by pertussis toxin (PTX). Neither a beta 1AR-selective agonist, xamoterol, nor a beta 2AR-selective agonist, procaterol, was able to stimulate transcription. However, both CGP 20712A and ICI 118,551 blocked isoproterenol-mediated effects to varying extents. PTX treatment also revealed that nuclear betaAR may be coupled to other signalling pathways in addition to Gi, as stimulation under these conditions reduced initiation of transcription below basal levels.These results highlight differential subcellular localization for betaAR subtypes and indicate that betaAR may have specific roles in regulating nuclear function in cardiomyocytes.
Current Topics in Immunohematology and Immunogenetics: Alexander S. Wiener Festschrift
Authors: John B. Miale
Journal: JAMA (1972)

It is indeed fitting that this volume, reprinted from<i>Haematologica 6</i>, No. 1-2, 1972, should be dedicated to Dr. A. S. Wiener on the occasion of his sixty-fifth birthday. From his early days as a pupil and associate of K. Landsteiner to the present, no one can match his significant contributions in the field of immunohematology and immunogenetics. The contents of this book pay due homage to his work. Ranganathon, Moor-Jankowski, and Unger put his contributions in historical perspective. The other contributors provide up-to-date reviews on blood procurement, immunogenetics, blood group biochemistry, biophysics and genetics, blood group serology, compatibility testing, prevention of Rh disease, and miscellaneous topics. The level of these contributions is appropriately high. This book is not only a fitting tribute to Dr. Wiener, but also an excellent source for all workers interested in immunohematology and immunogenetics. It is highly recommended.
DUST COVER FOR APPARATUS
Authors: Donald A. Laird
Journal: JAMA (1934)

To the Editor:—  A dust cover for apparatus, made from discarded x-ray films, was described by Dr. R. H. McClellan inThe Journal, Nov. 4, 1933. This useful and economical protection for instruments can be made more dust tight if Duco household cement is used to fasten the seams. I have also found that it is easier to construct the covers by cementing the seams than by using the stationers' piercing paper fasteners suggested by Dr. McClellan. Film cement, of course, could be used, but this is more expensive and has no advantage over the Duco cement except quicker drying. Care should be taken not to use the cement too generously; otherwise the film will be unduly softened and unworkmanlike joints produced.
"P" Wave Analysis in Valvular Heart Disease.
Authors: J. J. Morris
Journal: Annals of Internal Medicine (1963)

s1 April 1963"P" Wave Analysis in Valvular Heart Disease.J. J. Morris, M.D., E. H. Estes, M.D. (Associate), E. S. Orgain, M.D., F.A.C.P., H. K. Thompson, M.D., R. E. Whalen, M.D., H. D. McIntosh, M.D., F.A.C.P.J. J. Morris, M.D.Search for more papers by this author, E. H. Estes, M.D. (Associate)Search for more papers by this author, E. S. Orgain, M.D., F.A.C.P.Search for more papers by this author, H. K. Thompson, M.D.Search for more papers by this author, R. E. Whalen, M.D.Search for more papers by this author, H. D. McIntosh, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-4-715_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo improve the EKG recognition of left atrial involvement, a series of 200 patients was reviewed. One hundred patients had complete cardiac catheterization, including pressure measurement in all chambers and selective cineangiocardiography. Thirteen of this group had normal hemodynamics, and 87 had specifically defined single or multiple valve involvement. One hundred normal patients, ages 20 to 69, served as controls. Previously reported methods of "P" wave analysis failed to reveal a consistent method of separating normal patients from those with valvular disease.Theoretical consideration led to the conclusion that the terminal portion of the "P" wave in V1would best... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: J. J. Morris, M.D.; E. H. Estes, M.D. (Associate); E. S. Orgain, M.D., F.A.C.P.; H. K. Thompson, M.D.; R. E. Whalen, M.D.; H. D. McIntosh, M.D., F.A.C.P.Affiliations: Durham, N. C. (CS) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1963Volume 58, Issue 4Page: 715-715KeywordsCardiovascular therapyCatheterizationHemodynamicsValvular diseases ePublished: 1 December 2008 Issue Published: 1 April 1963 PDF downloadLoading ...
Poppering the Newell Test
Authors: Niels A. Taatgen
Journal: Behavioral and Brain Sciences (2003)

The Newell Test as it is proposed by Anderson &amp; Lebiere (A&amp;L) has the disadvantage of being too positivistic, stressing areas a theory should cover, instead of attempting to exclude false predictions. Nevertheless, Newell's list can be used as the basis for a more stringent test with a stress on the falsifiability of the theory.
Predictors of Achievement in Academic Medicine-Reply
Authors: Frederick L. Brancati
Journal: JAMA (1992)

<h3>In Reply.</h3> —Drs Fullilove, Fullilove, McCally, and Cassel are right to point out limitations in generalizability imposed by the composition of the cohort. Over 98% of the cohort is white; medical students of Asian ancestry account for most of the remainder. Thus, we were unable to examine predictors of achievement in racial subgroups. The cohort does include, however, 121 women who were the subject of two prior investigations regarding career choice and career achievement.<sup>1,2</sup>Of the 108 women (89%) who completed medical school and practiced medicine, 37 (34%) pursued academic careers. By 1985, seven (19%) of the academicians had achieved the rank of full professor. In comparison, male graduates were somewhat more likely to choose academic careers (45%) and much more likely to achieve the rank of professor, chairman, chief, or dean by 1990 (63%). Moreover, there were gender differences in the relationship of personal factors, such as marital
Exercise intolerance in patients with chronic heart failure and increased expression of inducible nitric oxide synthase in the skeletal muscle
Authors: Rainer Hambrecht, Volker Adams, Stephan Gielen, Axel Linke, Sven Möbius-Winkler, Jiangtao Yu, Josef Niebauer, Hong Jiang, Eduard Fiehn, Gerhard Schuler
Journal: Journal of the American College of Cardiology (1999)
Health authority admits mistakes over smear tests
Authors: R. Dobson
Journal: BMJ (1998)

A health authority has admitted that mistakes were made in assessing the results of cervical cancer smear tests on 14 women, two of whom have subsequently died.

Bro Taf health authority in South Wales said the women's smear test results had been classified as less severe than they should have been and that as a consequence treatment was delayed. The authority said that both of the deaths, and the hysterectomies and radiotherapy which the other women had subsequently undergone, might have been avoided had the …
ALCOHOLIC HEREDITY IN DISEASES OF CHILDREN.Read in the Section of Diseases of Children at the Forty-first Annual Meeting of the American Medical Association, at Nashville, Tenn,, May, 1890.
Authors: T. D. CROTHERS
Journal: JAMA (1890)

A. B. came under my care for home treatment for periodic inebriety. He has used wine on the table at meals for twenty years; for ten years past he had drank in paroxisms. His wife used wine on the table also, and during pregnancy and lactation had used both beer and wine freely. He had two children, one a girl of eight years, the other a boy five years old, both invalids, and had been under constant medical care from infancy, the general diagnosis being scrofula and general anæmia; and both were of pale and delicate appearance, extremely excitable and nervous. They had continuous irritation of the stomach, from an unrestricted diet of all kinds of foods and drinks, except wine and beer; were very passionate at the slightest opposition to their wishes, and after a period of rage would be greatly exhausted and have a distinct fever for a
Left Ventricular Hypertrophy and Abnormal Ventricular Geometry in Children and Adolescents with Obstructive Sleep Apnea
Authors: Raouf S. Amin, Thomas R. Kimball, Judy A. Bean, Jenny L. Jeffries, J. Paul Willging, Robin T. Cotton, Sandra A. Witt, Betty J. Glascock, Steven R. Daniels
Journal: American Journal of Respiratory and Critical Care Medicine (2002)

Obstructive sleep apnea (OSA) has been shown to be an independent risk factor for cardiovascular disease in adults. However, there are severe limitations in the extent to which the cardiovascular consequences of OSA are being studied in children. To investigate the echocardiographic changes in children with OSA, right and left ventricular (RV, LV) dimensions and LV mass index and geometry were measured in 28 children with OSA and 19 children with primary snoring (PS). The study showed that LV mass index and relative wall thickness were greater in the OSA group compared with those with PS (p = 0.012 and p &BLDlt; 0.0001, respectively). An apnea–hypopnea index of more than 10 per hour was significantly associated with RV dimension above the 95th percentile (odds ratios, 6.7; 95% confidence interval, 1.4–32) and LV mass index above the 95th percentile (odds ratios, 11.2; confidence interval, 1.9–64). Abnormality of LV geometry was present in 15% of children with PS compared with 39% of children with OSA. We conclude that OSA in children is associated with increased LV mass.
ILLUMINATING-GAS POISONING
Authors: MORRIS FISHBEIN
Journal: JAMA (1913)

I. THE EFFECT OF FORMALDEHYD ON TESTS FOR CARBON MONOXID IN THE BLOOD  In an examination of the blood from the body of a man in which post-mortem showed evidences of poisoning with illuminating gas (especially a brilliant red color of the muscles and blood), the question arose whether formaldehyd, used in embalming the body four days previously, would in any way modify or inhibit the various reactions ordinarily used to demonstrate the presence of carbon monoxid hemoglobin. A careful study of the literature failed to reveal any previous note on this subject, which may well be one of practical interest, especially in cases of a medicolegal nature.  The following preparations were studied by the spectroscope and by means of various chemical tests, which will be discussed individually: (1) the blood of the body examined post mortem after formaldehyd embalming; (2) normal blood; (3) normal blood containing formaldehyd solution; (4)
Number of patients from Gaza getting travel permits for medical treatment falls by 90%, says charity
Authors: Owen Dyer
Journal: BMJ (2008)

Patients are dying in the Gaza Strip because neighbouring governments are preventing them from seeking treatment outside the occupied territory, according to the Israeli medical charity Physicians for Human Rights Israel.

More than 40 patients with cancer and cardiac problems have died in recent months after being refused permission to leave through the Erez crossing by Israel’s military and intelligence services. Permits are often withheld for unspecified “security reasons,” even though patients have been accepted for referral by hospitals in Israel, the West Bank, Jordan, or Egypt.

The Palestinian Ministry of Health estimates that about 800 patients of all ages and …
Natural variation in passive sodium permeability in human erythrocytes
Authors: Jong Y. Lee, Ronald J. Prineas, Philip E. Hallaway, John W. Eaton
Journal: American Journal of Hematology (1987)

Abstract The rate of influx of 22 Na + into human erythrocytes (RBC) varies greatly depending upon the donor. A high rate of influx may be related to a congenital predisposition to essential hypertension. In Northern Europeans, we find a threefold difference in the rate of 22 Na + influx between those with the least (LP) and most highly permeable (HP) RBC (from &lt;0.15 to &gt;0.60 mmol Na + /liter RBC/hr). In order to further define determinants of these apparently hereditary differences in passive membrane Na + transport, we identified two groups of normal laboratory and hospital personnel differing markedly (&gt; twofold) in RBC 22 Na + influx rate. We find that the loop diuretics furosemide and bumetanide decrease by about 50% the influx of 22 Na + into HP RBC, but have a lesser influence on LP RBC. Impermeant polyanions such as citrate and pyrophosphate also specifically diminish 22 Na + influx into HP, but not LP, RBC. Therefore, the exaggerated 22 Na + influx into HP RBC probably occurs through a discrete pathway (perhaps via “Na/K/Cl cotransport”), which appears to be almost absent in LP RBC. The differences between HP and LP RBC most likely do not involve polymorphisms of RBC anion transport per se. The rate of RBC anion ( 35 SO 4 2– ) transport is the same in HP and LP RBC and is equally inhibited by furosemide and (to a lesser extent) bumetanide. Furthermore, the potent inhibitor of RBC anion transport, DIDS (diisothiocyanostilbene disulfonate) does not affect RBC Na + permeability in either group. Nonetheless, the preferential reduction of Na + permeation of HP RBC by loop diuretics may be of help in experimentally distinguishing HP from LP phenotypes. This information may be crucial in unraveling the structural basis of intrinsic differences in cell membrane Na + permeability and their possible relationship to essential hypertension.
Endotoxemia and Mediator Release During Colonoscopy
Authors: D. Berger, E. Boelke, A. Stanescu, K. Buttenschoen, C. Vasilescu, M. Seidelmann, H. G. Beger
Journal: Endoscopy (1995)

Previous clinical and experimental studies have shown evidence of a leakage of whole bacteria and bacterial products after major trauma through the gut barrier. By determining plasma endotoxin levels, products of the arachidonic pathway, interleukin-6, and the endotoxin-neutralizing capacity (ENC) of plasma during colonoscopy, we studied the gut barrier function and the pathogenetic sequelae of mediator release during a minimally invasive procedure.Thirty-two patients were enrolled in a controlled prospective study. Endotoxin and ENC were determined by a chromogenic modification of the limulus amebocyte lysate test. Prostanoids and interleukin-6 were measured using commercially available ELISA tests. C-reactive protein levels were checked by nephelometry.Twenty-one of the 32 patients had elevated endotoxin plasma levels during colonoscopy. In one patient, gut-derived bacteria were detected in plasma. ENC decreased after 5 min, and thromboxane B2 levels also started to increase at that time. No acute-phase response took place after 24 h.During colonoscopy, endotoxin can be detected in blood. ENC measurement was shown to be even more sensitive. The pathogenetic sequelae leading to gut barrier failure remain unclear, because mediator release and endotoxemia, as checked by ENC, took place simultaneously.
Selective inhibition of chymotrypsin-like activity of the immunoproteasome and constitutive proteasome in Waldenström macroglobulinemia
Authors: Aldo M. Roccaro, Antonio Sacco, Monette Aujay, Hai T. Ngo, Abdel Kareem Azab, Feda Azab, Phong Quang, Patricia Maiso, Judith Runnels, Kenneth C. Anderson, Susan Demo, Irene M. Ghobrial
Journal: Blood (2010)
Colonic fermentation of dietary fibre to short chain fatty acids in patients with adenomatous polyps and colonic cancer.
Authors: M R Clausen, H Bonnen, P B Mortensen
Journal: Gut (1991)

Short chain (C2-C6) fatty acids are produced in the colon through bacterial fermentation of mainly dietary fibre. Butyrate (C4) possesses antineoplastic effects on human colon carcinoma cells, and epidemiological studies indicate that high fibre diets may reduce the incidence of colorectal cancer. The role of dietary fibre during colorectal carcinogenesis might therefore be related to its fermentation to butyrate. Faecal concentrations of total short chain fatty acids and concentrations and ratios of the individual C2-C6 fatty acids did not differ between 16 healthy controls, 17 patients with colonic adenomas, and 17 patients with colonic cancer. Comparison of the molar production velocities (mmol/l.hour) of total and individual short chain fatty acids from glucose, ispagula, wheat bran, and albumin in six and 24 hour faecal incubations showed no differences. The ratio of butyrate production to total short chain fatty acid production from fibre, however, was reduced in patients with colonic cancer and adenomas compared with healthy controls (ispagula, six hours: 6.4, 7.6, and 11.5% respectively, p = 0.005 and 24 hour: 9.1, 9.9, and 15.4%, p = 0.002; wheat bran, six hours: 9.9, 10.2, and 14.7% respectively, p = 0.06 and 24 hours: 15.1, 16.8, and 21.0%, p = 0.01). It may be that the low ratios of colonic butyrate formation combined with low fibre diets increase the risk of colonic neoplasia.
Kyoto protocol ready for ratification after Marrakesh
Authors: K. Sheridan
Journal: BMJ (2001)

At the United Nations climate talks in Marrakesh, environment and energy ministers from 164 countries finally agreed the operational rulebook for the Kyoto protocol, the international climate change treaty that aims to combat global warming through a cut in emissions of greenhouse gases, particularly carbon dioxide.

It is hoped that widespread ratification of the treaty will follow, but at least 55 countries representing 55% of 1990 greenhouse gas emissions must agree ratification for the treaty to be …
The Emergence of Modern Nursing
Authors: Lester S. King
Journal: JAMA (1969)

In a field as restricted as the history of nursing, the appearance of a new edition only five years after the initial publication indicates that the book has met a real need. This volume, by Vern and Bonnie Bullough, recounts briefly the development of nursing activity from primitive times to the very present. The senior author (who was junior in the original edition) is well known for his historical studies of medieval medicine. The junior author, since the original edition, has acquired her PhD degree in sociology.  The Bulloughs have an interest in the dynamic progress of nursing, relative to other aspects of the health professions and to social and sociological problems. The best chapters are those which cover the medieval and early modern period, and so-called age of reform. The story of Florence Nightingale is especially well told. These chapters are rewarding to all readers. On the other hand,
Cancer Journals and Serials: An Analytical Guide
Authors: Ann C. Weller
Journal: JAMA (1988)

Journals, new and old, are not regularly reviewed.<i>Cancer Journals and Serials: An Analytical Guide</i>arrived with the expectation that it would fill a void and offer a guide to cancer journals useful to both the practitioner and the librarian who decides which journals to purchase for a library. The main body of the book annotates 372 alphabetically arranged journal and serial titles. Each annotation has two sections: bibliographic information and a description of the journal's contents. The bibliographic information has up to 25 categories, including standard bibliographic information, such as title, beginning year of publication, frequency, price, publisher, editor, circulation, and, if supplied by the publisher, availability of sample copies, regularity of supplements, presence of advertisements, level of target audiences, and selection of manuscripts for publication, including the use of editorial peer review. Information for the annotation was obtained from a direct examination of the journal and includes such