Localization of Adrenocorticotropic Hormone-Secreting Bronchial Carcinoid Tumor by Somatostatin-Receptor Scintigraphy
Authors: Mordechai Weiss
Journal: Annals of Internal Medicine (1994)

Brief Communications1 August 1994Localization of Adrenocorticotropic Hormone-Secreting Bronchial Carcinoid Tumor by Somatostatin-Receptor ScintigraphyMordechai Weiss, MD, Alon Yellin, MD, Monica Husza'r, MD, Zemach Eisenstein, MD, Jacob Bar-Ziv, MD, and Yodphat Krausz, MDMordechai Weiss, MDFrom the E. Wolfson Medical Center, Holon, Israel; Sheba Medical Center, Tel Hashomer, Israel; The Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; Hadassah University Hospital, Jerusalem, Israel.Search for more papers by this author, Alon Yellin, MDFrom the E. Wolfson Medical Center, Holon, Israel; Sheba Medical Center, Tel Hashomer, Israel; The Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; Hadassah University Hospital, Jerusalem, Israel.Search for more papers by this author, Monica Husza'r, MDFrom the E. Wolfson Medical Center, Holon, Israel; Sheba Medical Center, Tel Hashomer, Israel; The Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; Hadassah University Hospital, Jerusalem, Israel.Search for more papers by this author, Zemach Eisenstein, MDFrom the E. Wolfson Medical Center, Holon, Israel; Sheba Medical Center, Tel Hashomer, Israel; The Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; Hadassah University Hospital, Jerusalem, Israel.Search for more papers by this author, Jacob Bar-Ziv, MDFrom the E. Wolfson Medical Center, Holon, Israel; Sheba Medical Center, Tel Hashomer, Israel; The Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; Hadassah University Hospital, Jerusalem, Israel.Search for more papers by this author, and Yodphat Krausz, MDFrom the E. Wolfson Medical Center, Holon, Israel; Sheba Medical Center, Tel Hashomer, Israel; The Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; Hadassah University Hospital, Jerusalem, Israel.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-121-3-199408010-00007 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Most ectopic adrenocorticotropic hormone (ACTH)-secreting tumors are bronchial carcinoids [1], and many are malignant [2]. Intensive localization studies are therefore warranted. However, frequently, and especially in small centrally located tumors, various imaging modalities are inconclusive. Recently, somatostatin receptor scintigraphic studies using the radiolabeled long-acting somatostatin analog Indium-111-pentetreotide (Mallinckrodt Medical, Pettem, the Netherlands) have enabled the detection of medullary thyroid carcinoma and islet cell tumor, both secreting ACTH. However, a small ACTH-secreting bronchial carcinoid was not similarly identified [3]. We describe a patient with ACTH-producing malignant bronchial carcinoid in whom octreotide scintigraphy led to localization of the tumor and its successful ...References1. Doppman JL, Nieman L, Miller DL, Pass HI, Chang R, Cutler GB Jr, et al. Ectopic adrenocorticotropic hormone syndrome: localization studies in 28 patients. Radiology. 1989; 172:115-24. Google Scholar2. Leinung MC, Young WF Jr, Whitaker MD, Scheithauer BW, Trastek VF, Kvols LK. Diagnosis of corticotropin-producing bronchial carcinoid tumors causing Cushing's syndrome. Mayo Clin Proc. 1990; 65:1314-21. Google Scholar3. Lamberts SW, Hofland LJ, de Herder WW, Kwekkeboom DJ, Reubi JC, Krenning EP. Octreotide and related somatostatin analogs in the diagnosis and treatment of pituitary disease and somatostatin receptor scintigraphy. Front Neuroendocrinol. 1993; 14:27-55. Google Scholar4. van Noorden S, Varndell IA. Regulatory peptide immunocytochemistry at light- and electron microscopical levels. Experientia. 1987; 43:724-34. Google Scholar5. Jex RK, van Heerden JA, Carpenter PC, Grant CS. Ectopic ACTH syndrome. Diagnostic and therapeutic aspects. Am J Surg. 1985; 149:276-82. Google Scholar6. Findling JW. Eutopic or ectopic adrenocorticotropic hormone-dependent Cushing's syndrome? A diagnostic dilemma (Editorial). Mayo Clin Proc. 1990; 65:1377-80. Google Scholar7. Lamberts SW. The role of somatostatin in the regulation of anterior pituitary hormone secretion and the use of its analogs in the treatment of human pituitary tumors. Endocr Rev. 1988; 9:417-36. Google Scholar8. Hearn PR, Reynolds CL, Johansen K, Woodhouse NJ. Lung carcinoid with Cushing's syndrome: control of serum ACTH and cortisol levels using SMS 201-950 (sandostatin). Clin Endocrinol Oxf. 1988; 28:181-5. Google Scholar9. Cheung NW, Boyages SC. Failure of somatostatin analogue to control Cushing's syndrome in two cases of ACTH-producing carcinoid tumours. Clin Endocrinol Oxf. 1992; 36:361-7. Google Scholar10. Colombo P, Paganelli G, Magnani C, Fazio F, Faglia G. Scintigraphic studies with radiolabelled somatostatin analogue and anti-chromogranin A antibodies in patients with pituitary adenomas and ectopic Cushing's syndrome. J Endocrinol Invest 1993; 16(Suppl 1 to no. 8):S5. Google Scholar11. Phlipponneau M, Nocaudie M, Epelbaum J, DeKeyzer Y, Lalau JD, Marchandise X, et al. Somatostatin analogs for the localization and preoperative treatment of an adrenocorticotropin-secreting bronchial carcinoid tumor. J Clin Endocrinol Metab. 1994; 78:20-4. Google Scholar Author, Article, and Disclosure InformationAffiliations: From the E. Wolfson Medical Center, Holon, Israel; Sheba Medical Center, Tel Hashomer, Israel; The Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; Hadassah University Hospital, Jerusalem, Israel.Corresponding Author: Mordechai Weiss, MD, The E. Wolfson Medical Center, P.O. Box 5, Holon 58100, Israel. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAn ectopic Cushing’s syndrome as a cause of severe refractory hypokalemia in the ICUBeyond Adenocarcinoma: Current Treatments and Future Directions for Squamous, Small Cell, and Rare Lung Cancer HistologiesDivergent Role of 68Ga-Labeled Somatostatin Analogs in the Workup of Patients with NETs: AIIMS ExperienceSuccessful application of technetium-99m-labeled octreotide acetate scintigraphy in the detection of ectopic adrenocorticotropin-producing bronchial carcinoid lung tumor: a case reportImaging for the Differential Diagnosis of Cushing’s Syndrome: MRI, CT, and Isotopic ScanningSomatostatin receptor imaging for neuroendocrine tumorsEctopic Cushing’s SyndromeSomatostatin Receptor ImagingClinical-radiological presentation and outcome of surgically treated pulmonary carcinoid tumours: a long-term single institution experienceOctreoscan in patients with bronchial carcinoid tumoursCyclical Cushing’s Syndrome in a Patient with a Bronchial Neuroendocrine Tumor (Typical Carcinoid) Expressing Ghrelin and Growth Hormone Secretagogue ReceptorsSPECT/CT hybrid imaging with 111 In-pentetreotide in assessment of neuroendocrine tumoursSPECT/CT in tumor imaging: Technical aspects and clinical applicationsSomatostatin receptor imagingTumor carcinoide bronquial y gammagrafía de receptores de somatostatina: detección de metástasis óseasFrom the Archives of the AFIPReceptor imaging in the diagnosis and treatment of pituitary tumorsDetection of primary breast cancer presenting as metastatic carcinoma of unknown primary origin by 111In-pentetreotide scanSomatostatin-Receptor Scintigraphy in the Management of Gastroenteropancreatic TumorsLocalization and postoperative follow-up of a bronchial carcinoid tumor causing Cushing’s syndrome by 111In-DTPA labelled octreotide scintigraphyIs there a role for somatostatin and its analogs in Cushing's syndrome?Somatostatin Analogue Therapy 1 August 1994Volume 121, Issue 3Page: 198-199KeywordsAdrenocorticotropic hormoneBlood plasmaBlood pressureCarcinoid tumorComputed axial tomographyCortisolPulmonary arteriesRadionuclide imagingSomatostatinThorax Issue Published: 1 August 1994 CopyrightCopyright © 1994 by American College of Physicians. 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