tbuckley/cabot-search huggingface dataset:
Magnesium sulphate added to standard treatment in acute severe asthma causes significantly higher FEV1 % predicted at 4 hours
Authors: T A R Seemungal
Journal: Thorax (2003)

▴ Silverman RA, Osborn H, Runge J, et al for the Acute Asthma/Magnesium Study Group. IV magnesium sulphate in the treatment of acute severe asthma: a multicenter randomized controlled trial. Chest2002;122:489–97 [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] A randomised, double blind, placebo controlled trial of intravenous (IV) magnesium sulphate (2 g/50 ml normal saline) was performed during standard treatment of 248 patients seen in the … [1]: {openurl}?query=rft.jtitle%253DChest%26rft.stitle%253DChest%26rft.issn%253D0012-3692%26rft.aulast%253DSilverman%26rft.auinit1%253DR.%2BA.%26rft.volume%253D122%26rft.issue%253D2%26rft.spage%253D489%26rft.epage%253D497%26rft.atitle%253DIV%2BMagnesium%2BSulfate%2Bin%2Bthe%2BTreatment%2Bof%2BAcute%2BSevere%2BAsthma%2A%2B%253A%2BA%2BMulticenter%2BRandomized%2BControlled%2BTrial%26rft_id%253Dinfo%253Adoi%252F10.1378%252Fchest.122.2.489%26rft_id%253Dinfo%253Apmid%252F12171821%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1378/chest.122.2.489&link_type=DOI [3]: /lookup/external-ref?access_num=12171821&link_type=MED&atom=%2Fthoraxjnl%2F58%2F1%2F13.atom [4]: /lookup/external-ref?access_num=000177449400020&link_type=ISI
MARROW HYPERPLASIA AND HEMOGLOBIN RESERVE IN EXPERIMENTAL ANEMIA DUE TO BLEEDING
Authors: L. W. F. Oehlbeck, F. S. Robscheit-Robbins, G. H. Whipple
Journal: The Journal of Experimental Medicine (1932)

In long continued severe anemia due to bleeding in dogs we may observe all degrees of red marrow spread. The maximal red marrow spread takes in the total marrow area in ribs, vertebrae and long bones. The minimal red marrow spread may involve but 10 to 20 per cent of this maximal area. All gradations between these extremes are observed in this series. The extent of the red marrow spread is not dependent upon the length of the anemia period nor is it related to the capacity of the dog to produce new hemoglobin and red cells on standard diets. Evidence points to the liver as concerned with this hemoglobin production and liver function may set the limits for hemoglobin production on these standard diets. This in turn may determine the needful red marrow spread. During favorable diet periods there is a storage of hemoglobin or hemoglobin precursors which come out later in the control periods as finished red cells. This reserve of hemoglobin producing material is not stored as mature red cells in the marrow or elsewhere but as intermediates stored probably in the liver and red marrow but also perhaps in the kidney and spleen. Red marrow very rarely gives evidence of exhaustion even after many years of continuous severe anemia (Dog 18-114). This would seem to consist of a shrinkage of the red marrow area rather than a degenerative change of the red marrow cells. The spleen shows some evidence of erythrogenesis in these dogs. Megakaryocytes in some instances are conspicuous (Fig. 6) and nests of nucleated red cells are found in the spleen pulp but it is unlikely that the spleen contributes any large amount of red cells to the anemic circulation in these experiments. There is no evidence that erythrogenesis occurs in the liver or lymphatic tissue in these dogs.
METHYL-HYDRAZINE IN TREATMENT OF HODGKIN'S DISEASE AND VARIOUS FORMS OF HÆMATOSARCOMA AND LEUKÆMIA
Authors: G. Mathé, O. Schweisguth, M. Schneider, J.L. Amiel, L. Berumen, G. Brule, A. Cattan, L. Schwarzenberg
Journal: The Lancet (1963)
New Soviet Surgical Apparatus and Instruments and Their Application
Authors: F. T. Jung
Journal: JAMA (1961)

The editorial preface states that this book is a compilation of reports given at the First Scientific Session of the Scientific Research Institute for Experimental Surgical Apparatus and Instruments, held in December, 1956, to sum up the first 5 years of the work of the Institute. There are 34 chapters by different authors. Some chapters are remarkably brief; the statements are often quite general; and a dearth of illustrations makes for a disappointing vagueness of presentation. The chapters on artificial blood circulation and on electric narcosis indicate that these subjects are in the same unsatisfactory state in Russia as they are in the United States. The work of translating has been expertly done, but the work as a whole gives an impression of perfunctoriness. The absence of an alphabetical index makes it hard to locate particular items of interest. This book can be recommended only to a few patient readers
Pharmacokinetics in the infant.
Authors: R L Milsap, W J Jusko
Journal: Environmental Health Perspectives (1994)

Processes controlling the absorption, distribution, metabolism, excretion, and pharmacologic effects of drugs are likely to be immature or altered in neonates and infants. Absorption may be affected by differences in gastric pH and stomach emptying rate. Low serum protein concentrations and higher body water composition can change drug distribution. Drug metabolism enzyme activity is typically reduced in the neonate, but rapidly develops over the first year of life. Renal excretion mechanisms are low at birth, but mature over a few months. Limited data are available on the pharmacodynamics of drugs; infants show greater sensitivity to d-tubocurarine. Developmental changes are rapid during the first weeks and months of life, thus requiring continual modification of drug dosage regimens designed for treating pediatric patients.
830-5 The impact of myocardial blush grade on clinical outcomes of patients treated with saphenous vein grafts and thrombotic native coronary arteries: Analysis from the X-TRACT trial
Authors: Yoshihiro Tsuchiya, Alexandra J Lansky, Ricardo A Costa, Roxana Mehran, Manuela Negoita, Ecaterina Cristea, Horia Marginean, Maria Corral, Moses Tarawali, Joseph Babb, David A Cox, Gregg W Stone
Journal: Journal of the American College of Cardiology (2004)
Patients' knowledge of their condition and treatment: how it might be improved.
Authors: H Dunkelman
Journal: BMJ (1979)

A study was carried out in which patients were asked questions to assess their knowledge of their condition and treatment, the questions relating particularly to care before siting an intravenous infusion and preoperative care. A high proportion of patients knew little about the procedure they were about to undergo. It is recommended that patients should be told more about matters relating to their condition and treatment. Written information could be given to supplement that given verbally by staff. A check list might be drawn up to ensure that patients receive all relevant information.
Treatment for Necrotizing Soft-Tissue Infections
Authors: Robert G. Sawyer
Journal: JAMA Surgery (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Myc regulates aggresome formation, the induction of Noxa, and apoptosis in response to the combination of bortezomib and SAHA
Authors: Steffan T. Nawrocki, Jennifer S. Carew, Kirsteen H. Maclean, James F. Courage, Peng Huang, Janet A. Houghton, John L. Cleveland, Francis J. Giles, David J. McConkey
Journal: Blood (2008)
Bone Scanning-Reply
Authors: Leonard M. Freeman
Journal: JAMA (1976)

The comments made by Dr Cox are not necessarily in conflict with our original letter. We mentioned diffuse skeletal disorders, such as breast or prostate metastases, as the probable cause of the diminished renal uptake in the particular case in question. We have observed it on several occasions, as has Sy et al.<sup>1</sup>It has proved quite useful. Unfortunately, Dr Cox has not observed it in diffuse skeletal disease as often as a number of other investigators have. My co-authors and I did not wish to imply that diffuse skeletal disease was the only cause of the faint or absent kidney sign. Certainly, primary kidney failure is a major consideration. Additionally, some of Dr Cox's comments regarding the form of the technetium complex may provide another reason for decreased kidney concentration. The important consideration is that the variation from the normal is appreciated. The cause of the
Fulminant metastatic calcinosis with cutaneous necrosis in a child with end-stage renal disease and tertiary hyperparathyroidism
Authors: Ch.C. ZOUBOULIS, U. BLUME-PEYTAVI, Th. LENNERT, P.G. STAVROPOULOS, A. SCHWARZ, N. RUNKEL, Ch. TRAUTMANN, C.E. ORFANOS
Journal: British Journal of Dermatology (1996)

Metastatic calcinosis is a common feature of chronic renal failure. Its first manifestations are bone demineralization and non-visceral and/or visceral calcification with mostly mural deposits in arteries and arterioles. It is initially characterized by hyperphosphataemia followed by secondary or tertiary hyperparathyroidism. Cutaneous involvement is a rare complication. Histologically, the lesions show vascular calcification with ischaemic skin necrosis. Extreme cases may produce calcinosis cutis (calciphylaxis), i.e. disseminated calcification of the subcutaneous tissue and dermis in the form of hard painful cutaneous nodules and plaques with subsequent ulceration. Metastatic calcinosis is a disease affecting adults, while the dystrophic or idiopathic type can develop in children. We present the case of a 6-year-old boy with end-stage renal disease, attributed to congenital renal hypoplasia, and accompanied by secondary hyperparathyroidism. He developed fulminant tertiary hyperparathyroidism and metastatic calcinosis of the lungs, as well as cutaneous necrosis of the buttocks and legs, subsequent to calcification of arteries and arterioles. A maternal renal transplant failed to function. The serum parathormone, calcium and phosphate levels could not be controlled by maintenance dialysis, phosphate binders and calcitriol. Total parathyroidectomy without autotransplantation of parathyroid tissue rapidly returned the serum parathormone, calcium and phosphate levels to normal. In addition, topical treatment using merbromine solution and hydrocolloid dressings, healed the ulcers with significant scar formation, within 2.5 months after parathyroidectomy. A renewed increase of the calcium x phosphate product, 2 months after parathyroidectomy, was attributed to mobilization of calcium compounds from the viscera, as confirmed by a chest X-ray.
Still Life Within the Painter’s Heart
Authors: Margaret A. Campbell
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
1259 CELL CYCLE ARREST AND ACCELERATED TELOMERE SHORTENING IN NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD)
Authors: A. Aravinthan, C. Scarpini, P. Tachtatzis, S. Penrhyn-Lowe, S. Verma, S. Davies, R. Brais, N. Coleman, M. Allison, G. Alexander
Journal: Journal of Hepatology (2011)
EG-03 * EXPRESSION OF PRMT5 CORRELATES WITH MALIGNANT GRADE IN GLIOMAS AND PLAYS A PIVOTAL ROLE IN TUMOR GROWTH
Authors: X. Han, R. Li, W. Zhang, X. Yang, H. Fathallah-Shaykh, Y. Gillespie, B. Nabors
Journal: Neuro-Oncology (2014)

Protein arginine methyltransferase 5 (PRMT5) catalyzes the formation of ω-NG,N′G-symmetric dimethylarginine residues on histones as well as other proteins. The modification play an important role in cell differentiation and tumor cell growth. However, the role of PRMT5 in human glioma cells has not been characterized. In this study, we assessed protein expression profiles of PRMT5 in control brain, WHO grade II astrocytomas, anaplastic astrocytomas, and glioblastoma multiforme (GBM) by immunohistochemistry. PRMT5 was low in glial cells in control brain tissues and low grade astrocytomas. Its expression increased in parallel with malignant progression, and was highly expressed in GBM. Knockdown of PRMT5 by small hairpin RNA caused alterations of p-ERK1/2 and significantly repressed the clonogenic potential and viability of glioma cells. These findings indicate that PRMT5 is a marker of malignant progression in glioma tumors and plays a pivotal role in tumor growth.
Not everything that counts can be easily counted
Authors: H. J. Marcus, A. Hughes-Hallett, T. P. Cundy, D. Nandi, G.-Z. Yang, A. Darzi
Journal: BMJ (2013)

Paul and colleagues highlight the need for national registries on robotic surgery to collect data on rare events, long term outcomes, and quality assurance more effectively.1 However, it would be hasty to draw conclusions on the comparative effectiveness of robotic versus traditional minimally invasive surgery on the basis of such information alone.

Robotic assistance is an adjunct to traditional minimally invasive …
Hypertrophic Osteoarthropathy Associated with Carcinoma of Stomach
Authors: A. Singh, S. S. Jolly, B. B. Bansal
Journal: BMJ (1960)

IC JO ~AHg.There was no secretion in the breasts.The abdomen was slightly distended below the umbilicus but no mass was palpable.Tenderness and resistance were present in the lower abdomen, and it was not dull to percussion.On vaginal examination the cervix was slightly softened, but the body of the uterus was not clearly defined because of the abdominal resistance.An extremely tender indefinite mass was felt in the right fornix and she was very tender in the pouch of Douglas and experienced pain on movement of the cervix.A provisional diagnosis of ruptured ectopic gestation or haemorrhage from a follicular or endometriotic cyst of the right ovary was made.Blood was taken for cross-matching, and an intravenous drip of 1 pint (568 ml.) of dextran was started, followed by 3 pints (1,704 ml.) of blood.At laparotomy about 11 pints (852 ml.) of fluid blood and clots were removed from the peritoneal cavity.Both tubes and ovaries were normal.The uterus was enlarged by a subserous uterine fibroid about 2 by 2j in.(5 by 6.2 cm.), situated on the right side of the anterior surface of the uterus just below the right cornu.On the surface of the fibroid were several thin-walled veins, one of which had ruptured and was bleeding freely.There were no adhesions around the uterus.Myomectomy was performed and the uterine wall closed.The fibroid was very superficial in the uterine wall, and the resulting scar was only about 1 in. (2.5 cm.) long.The patient had a post-operative respiratory infection, but otherwise made an uneventful recovery.The pathologist reported a fibromyoma measuring 6 by 5 cm., containing haemorrhages.Microscopical examination revealed areas of oedema and thrombosis.
The significance of haemochromatosis gene mutations in the general population: implications for screening
Authors: M J Burt, P M George, J D Upton, J A Collett, C M A Frampton, T M Chapman, T A Walmsley, B A Chapman
Journal: Gut (1998)

Background —Haemochromatosis is associated with mutations in the HFE gene but the significance of these mutations in the general population is unknown. Aims —To determine the frequency of HFE gene mutations in the general population, their effect on serum iron indexes, and their role in screening for haemochromatosis. Methods —Deoxyribonucleic acid (DNA) from 1064 randomly selected subjects was analysed for the C282Y and H63D mutations in the HFE gene. Serum iron, transferrin saturation, and ferritin were measured and individuals with increased iron indexes were investigated to confirm or exclude a clinical diagnosis of haemochromatosis. Results —Mutations were identified in 409 individuals (38.4%) with heterozygote (carrier) frequencies of 13.2% and 24.3% for the C282Y and H63D mutations respectively. Heterozygosity for either mutation significantly increased serum iron and transferrin saturation but despite a similar trend for ferritin, this was only significant for C282Y homozygotes. Five individuals (0.47%) were homozygous for the C282Y mutation, three of whom had haemochromatosis confirmed by liver biopsy (0.28%). The other two C282Y homozygotes would not have been detected by phenotypic screening alone. Conclusions — HFE mutations are present in 38.4% of the population, affect serum iron indexes, and are important determinants of iron status. The population frequency of genetically defined haemochromatosis (C282Y homozygosity) is approximately one in 200 and is higher than the prevalence of clinically apparent haemochromatosis.
FDA rejects sale of over the counter statins
Authors: Owen Dyer
Journal: BMJ (2005)

An expert advisory panel at the Food and Drug Administration last week rejected a proposal to permit over the counter sales of Merck's statin lovastatin (Mevacor), arguing that the risk of the drug could outweigh its benefits in many potential users.

If Merck's proposal had been accepted, lovastatin would have become the first long term preventive treatment to make the switch from prescription to over the counter status in the United States.

The decision is not binding, but the FDA hardly ever rejects the opinions of its own expert advisers. Although several leading cardiologists had publicly backed the proposal, the advisory panel voted against approval by a resounding margin of 20 to 3.

During the panel's public testimony session, several of the members who eventually voted against …
Altered transcription of genes coding for class I histocompatibility antigens in murine tumor cells.
Authors: P Baldacci, F Pozo, S Gisselbrecht, P Kourilsky
Journal: The Journal of Experimental Medicine (1983)

Three murine tumors induced by Moloney murine leukemia virus (M-MLV) which exhibited loss of some or all H-2 class I antigens at the cell surface were analyzed at the DNA and RNA level with molecular probes specific of H-2 heavy chains and beta 2-microglobulin sequences. No observable difference could be detected at the DNA level between the tumors and the parent animals. However, a decrease in H-2 mRNA was observed, especially in phenotypically H-2 negative tumor, BM5R, where H-2 transcripts were at least 30-fold less abundant. These results show that an H-2-negative character may result from a general alteration in the transcription of H-2 genes, which could reflect some kind of regulatory process.
Spontaneous expulsion of a large colonic tumour.
Authors: D A Robertson, W Saweirs, T S Low-Beer
Journal: BMJ (1982)

There was no history of taking other drugs known to cause gynaecomastia.Despite the lack of other penicillamine-related side effects, the drug was discontinued.Two months later the gynaecomastia receded, and over the next two years his breasts remained normal.
The Do-Not-Resuscitate Order
Authors: MICHAEL J. SHAPIRO
Journal: Annals of Internal Medicine (1983)

Letters and Corrections1 May 1983The Do-Not-Resuscitate OrderMICHAEL J. SHAPIRO, B.A.MICHAEL J. SHAPIRO, B.A.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-98-5-669_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The article by Miles and associates (1) shows that only the practical need to deal with the do-not-resuscitate order exceeds the difficulties of the issue. Therefore, I praise the efforts of the authors before I raise another question.In contrast to medical treatment where outcome is the accepted arbiter of correctness, there are no objective results in medical ethics accepted as correct by all adherents of the various ethical theories. Nonetheless the proponents of each ethical theory agree that ethical correctness arises from consistent adherence to ones' principles. To achieve consistence a clear understanding of ones' ethical...Reference1. MILESCRANFORDSCHULTZ SRA. The do-not-resuscitate order in a teaching hospital: considerations and a suggested policy. Ann Intern Med. 1982;96:660-64. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MICHAEL J. SHAPIRO, B.A. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1983Volume 98, Issue 5_Part_1Page: 669-669KeywordsDo not resuscitate ordersMedical ethics ePublished: 1 December 2008 Issue Published: 1 May 1983 PDF downloadLoading ...