tbuckley/cabot-search huggingface dataset:
Toxic Shock-like Syndrome with Flu-like Prodrome: aPossible Role of 'Enhancing Tissue Focus' forStreptococcal Toxic Shock
Authors: Y. Hirose, H. Shibuya, E. Okazaki, K. Aono, A. Tokunaga, S. Taguchi, M. Haraguchi, H. Honda
Journal: Journal of Infection (2001)
Occupation, Education, and Coronary Heart Disease.
Authors: Lawrence E. Hinkle
Journal: Annals of Internal Medicine (1968)

s1 May 1968Occupation, Education, and Coronary Heart Disease.Lawrence E. Hinkle Jr., M.D., F.A.C.P., Edward W. Lehman, Ph.D., L. Holland Whitney, M.D., F.A.C.P., James Dunn, M.D., F.A.C.P., Bry Benjamin, M.D., F.A.C.P., Robert King, Arlene Plakun, Betty Flehinger, Ph.D.Lawrence E. Hinkle Jr., M.D., F.A.C.P.Search for more papers by this author, Edward W. Lehman, Ph.D.Search for more papers by this author, L. Holland Whitney, M.D., F.A.C.P.Search for more papers by this author, James Dunn, M.D., F.A.C.P.Search for more papers by this author, Bry Benjamin, M.D., F.A.C.P.Search for more papers by this author, Robert KingSearch for more papers by this author, Arlene PlakunSearch for more papers by this author, Betty Flehinger, Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-5-1156_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo study the relation between social mobility and coronary heart disease (CHD) from January 1, 1962, through December 21, 1966, sickness absences and deaths potentially representing episodes of CHD among the 270,000 men in the Bell System were investigated. Clinical characteristics, electrocardiogram, and laboratory and pathological findings were reported to New York and classified according to the American Heart Association U. S. Public Health Service criteria. Completeness of reporting was checked by independent review of 1,735 death certificates, representing 98% of all deaths in the System in 1964. Classification of illnesses was checked by independent investigation of a random sample... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Lawrence E. HinkleJr., M.D., F.A.C.P.; Edward W. Lehman, Ph.D.; L. Holland Whitney, M.D., F.A.C.P.; James Dunn, M.D., F.A.C.P.; Bry Benjamin, M.D., F.A.C.P.; Robert King; Arlene Plakun; Betty Flehinger, Ph.D.Affiliations: New York, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1968Volume 68, Issue 5Page: 1156-1156KeywordsCongenital heart diseaseCoronary heart diseaseElectrocardiographyHeartLongitudinal studiesMedical servicesResearch laboratories ePublished: 1 December 2008 Issue Published: 1 May 1968 PDF downloadLoading ...
Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease
Authors: Zhiping Li, Shiqi Yang, Huizhi Lin, Jiawen Huang, Paul A. Watkins, Ann B. Moser, Claudio DeSimone, Xiao-yu Song, Anna Mae Diehl
Journal: Hepatology (2003)

Ob/ob mice, a model for nonalcoholic fatty liver disease (NAFLD), develop intestinal bacterial overgrowth and overexpress tumor necrosis factor α (TNF-α). In animal models for alcoholic fatty liver disease (AFLD), decontaminating the intestine or inhibiting TNF-α improves AFLD. Because AFLD and NAFLD may have a similar pathogenesis, treatment with a probiotic (to modify the intestinal flora) or anti-TNF antibodies (to inhibit TNF-α activity) may improve NAFLD in ob/ob mice. To evaluate this hypothesis, 48 ob/ob mice were given either a high-fat diet alone (ob/ob controls) or the same diet + VSL#3 probiotic or anti-TNF antibodies for 4 weeks. Twelve lean littermates fed a high-fat diet served as controls. Treatment with VSL#3 or anti-TNF antibodies improved liver histology, reduced hepatic total fatty acid content, and decreased serum alanine aminotransferase (ALT) levels. These benefits were associated with decreased hepatic expression of TNF-α messenger RNA (mRNA) in mice treated with anti-TNF antibodies but not in mice treated with VSL#3. Nevertheless, both treatments reduced activity of Jun N-terminal kinase (JNK), a TNF-regulated kinase that promotes insulin resistance, and decreased the DNA binding activity of nuclear factor κB (NF-κB), the target of IKKβ, another TNF-regulated enzyme that causes insulin resistance. Consistent with treatment-related improvements in hepatic insulin resistance, fatty acid β-oxidation and uncoupling protein (UCP)-2 expression decreased after treatment with VSL#3 or anti-TNF antibodies. In conclusion, these results support the concept that intestinal bacteria induce endogenous signals that play a pathogenic role in hepatic insulin resistance and NAFLD and suggest novel therapies for these common conditions.
Treat patients with kindness during magnetic resonance imaging
Authors: K. Duncan, P. N Baker, I. R Johnson, P. Gowland
Journal: BMJ (1996)

EDITOR,—We were concerned to read Helen Rosenthal's personal view, in which she described her harrowing experience of magnetic resonance imaging and likened the technique to the Auschwitz gas chambers.1 Her view is contrary to the impression we have gained of our patients' satisfaction with this imaging modality. We are currently investigating the use of echoplanar magnetic resonance imaging to assess fetal development.2 One aspect of the research is a longitudinal study …
A METHOD OF SUTURING THE GALL-BLADDER TO THE PARIETES IN GALL-BLADDER OPERATIONS.
Authors: WILLIAM WOTKYNS SEYMOUR
Journal: JAMA (1902)

In my last twenty cases I have attached the gall-bladder to the parietes in the following manner: A full curved Hagedorn needle is threaded with silkworm gut and passed mattress-stitch fashion from within the gall-bladder through the peritoneum, overlying muscle and fascia; then it is brought out and reintroduced and carried out through the skin a short distance from the wound. The opposite end of the silkworm gut is introduced in the same manner and the ends fastened by two or three shot, the uppermost of which is crushed. At first I used five sutures of this character to suspend the gall-bladder, but now I rarely use more than three. The suspension sutures are removed on the tenth day, or earlier, if indicated. The advantage in this form of suture is that there is no danger of the sutures falling into the gall-bladder to become the nidus of new concretions
In vivovalidation of lesion length measurements using motorized pullback of intravascular ultrasound transducers
Authors: Rolf T. Fuessl, Gary S. Mintz, Jeffrey J. Popma, Lowell F. Satler, Kenneth M. Kent, Augusto D. Pichard, Rainer Hoffman, Roxana Mehran, Jennifer Griffin, Anne Goldstein, Kathi Donovan, Martin B. Leon
Journal: Journal of the American College of Cardiology (1996)
Clinical study and stability assessment of a novel transcutaneous influenza vaccination using a dissolving microneedle patch
Authors: Sachiko Hirobe, Hiroaki Azukizawa, Takaaki Hanafusa, Kazuhiko Matsuo, Ying-Shu Quan, Fumio Kamiyama, Ichiro Katayama, Naoki Okada, Shinsaku Nakagawa
Journal: Biomaterials (2015)
"FAULTY BLOOD GROUPING DUE TO AUTO-AGGLUTININS"
Authors: Emil Rothstein
Journal: JAMA (1933)

<h3>To the Editor:</h3> —InThe Journal, July 15, is an article by Manheims and Brunner on faulty blood grouping due to autoagglutinins. One precaution to avoid such false interpretations is suggested in the form of cross-matching before the transfusion. However, faulty blood grouping, even when detected in time to avert a serious transfusion reaction, is a cause of delay, expense and embarrassment; occasionally the patient may suffer by the delay. At the Brooklyn Jewish Hospital, where all transfusions are performed by the Department of Pathology under the continual personal supervision of Dr. Silik Polayes, it is the rule that when an AB blood is found it is immediately tested for auto-agglutination by the mixing of one drop each of the patient's cell suspension and patient's serum at room temperature. If agglutination is present, regrouping is performed with washed cells. Careful attention to such and similar details will bring to a
The Blood in Disease
Authors: Steven O. Schwartz
Journal: JAMA (1968)

This very good, highly readable, practical little book covers the every-day field of hematology. Intended "for the student of clinical hematology and for the physician who occasionally meets disorders of the blood in his practice," it is obviously written by a clinician with considerable experience and common sense approach. Simple things are simply put, complex problems lucidly presented, and obscure or ill-understood phenomena pointed out as such. There is no attempt to theorize or speculate about the unknown or unexplained facets one confronts only too often. The distribution of the material is approached from a physiologic or pathophysiologic point of view, so that one can profitably read each chapter through, though perhaps interesting oneself in only a particular point. The index is good. The bibliography is limited, but there is usually a good reference to a recent definitive article on almost every subject. There is not enough emphasis on the
Phenformin Acidosis-Reply
Authors: Robert E. Tranquada
Journal: JAMA (1964)

<h3>To the Editor:—</h3> We acknowledge our error in the interpretation of the work of Wick et al and extend our apologies to those authors. It is unfortunate that the experience of Dr. Freedman and Mr. Blitz with our method for phenformin assay varied so much from our own. Our comparison (before and after dialysis) of the absorption of extracts of 16 sera, two of which represented pooled specimens from approximately 50 hospitalized patients each, reveals a maximum difference of 11% and a mean difference of 6%. Studies of the effect of added creatinine on the phenformin procedure reveal that creatinine is removed from the original serum so inefficiently that serum creatinine levels at or above 10 mg/100 ml are required before any significant contribution to final ultraviolet absorption is seen. Arginine is not present in sufficient concentration in serum to affect the determination. Furthermore, duplicate determinations on 48 serum specimens
The Chronicity of Symptoms and Disability in Reiter's Syndrome
Authors: ROBERT FOX
Journal: Annals of Internal Medicine (1979)

To assess the natural history of Reiter's disease, we evaluated 131 consecutive patients at a university clinic or at a community center. One hundred twenty-two patients (93%) were available for follow-up at a mean of 5.6 years. The results showed that there were no major differences between patients at the two centers; at follow-up, 101 (83%) had some disease activity, 27 (22%) had annoying symptoms, 42 (34%) had sustained disease activity, 19 (16%) had had to change jobs, and 13 (11%) were unemployable; there were no major differences between the 19 (15%) females and 112 (85%) males or between the HLA-B27-positive (83%) and -negative (17%) patients, except for increased prevalence of sacroiliitis and chronic uveitis in HLA-B27 -positive patients; and, at entry, only increased heel disease differentiated those destined to have a poor prognosis. Most patients with Reiter's syndrome have persisting symptoms that can lead to chronic disability.
THE WORSHIPFUL COMPANY OF SPECTACLE MAKERS
Authors: L. Laurance
Journal: BMJ (1902)

Clinical experience suggests that there is a cohort of patients with refractory colitis who do have faecal stasis that contributes to symptoms. The underlying physiology is poorly understood, partly because until recently the technology to examine segmental colonic motility has not existed. Patients are given little information on how proximal faecal stasis can complicate colitis. Treatment guidelines are scanty and many patients are offered little apart from laxatives and advice on increasing fibre intake, which often makes symptoms worse. This article aims to review the history, pathology and management, and create impetus for future research on this underappreciated condition.
Governments as facilitators or obstacles in the HIV epidemic
Authors: A. J Ammann
Journal: BMJ (2002)

The current trajectory of the HIV/AIDS epidemic is unlikely to change quickly. Five million people will become infected each year despite decades of research that has discovered every preventable means of HIV transmission—via sex, intravenous drug use, blood transfusion, breast feeding, and perinatal transmission.1 We could try to blame science for having failed to perform research that affects international public health. But the transition from successful clinical research to implementation of public health rests in the hands of governments.

Faced with a crisis of enormous proportions, how do we motivate governments to mount a vigorous public health response? Initially, in the early 1980s, the US government was slow to act, but with constant prodding by activists over $9.7bn is now spent annually for research, education, prevention, and treatment. New HIV infections in the United States have fallen from a peak of about 150 000/year in the 1980s to 40 000/year currently.2 Here …
Acute hepatitis C virus (HCV) infection in chronic carriers of hepatitis B virus (HBV): the impact of underlying active HBV replication on persistence of HCV infection and antibody responses to HCV
Authors: C-M Chu, C T Yeh, I S Sheen, Y F Liaw
Journal: Gut (2002)

<b>Background and aims:</b> The aim of this study was to assess whether underlying chronic hepatitis B virus (HBV) infection interferes with persistence of hepatitis C virus (HCV) infection and humoral immune responses to HCV in acute HCV infection. <b>Methods:</b> Serial sera from 12 patients with acute HCV infection (group A) and 12 hepatitis B surface antigen (HBsAg) carriers with acute HCV infection (seven anti-hepatitis B e antigen (anti-HBe) positive (group B1) and five hepatitis B e antigen (HBeAg) positive (group B2)) were tested for HCV RNA by polymerase chain reaction, and anti-HCV by third generation enzyme immunoassay and confirmatory assay. Serial serum samples from HBsAg carriers were also tested for HBeAg, anti-HBe, and HBV DNA by hybridisation assay. <b>Results:</b> Persistent HCV viraemia for more than six months was significantly more frequent in groups A (83%) and B1 (86%) than in group B2 (0%). Anti-HCV was detected in 100% and 86% of group A and group B1 one month after onset while only one group B2 patient was transiently anti-HCV positive 1–2 months after onset. Of the latter, three had anti-core 1 less than two months after onset while no patient responded to other HCV antigens. Overall, of six HBsAg carriers with acute self limiting HCV infection, only one had transient anti-HCV and three had transient anti-core 1. HBV DNA became undetectable transiently in four and persistently in one group B2 patient. <b>Conclusion:</b> The presence of active HBV replication can inhibit the persistence of HCV infection and antibody responses to HCV. Acute HCV infection in HBsAg carriers with active HBV replication usually presents transient HCV viraemia with poor antibody responses to HCV.
Six versus fewer planned cycles of first-line platinum-based chemotherapy for non-small-cell lung cancer: a systematic review and meta-analysis of individual patient data
Authors: Antonio Rossi, Paolo Chiodini, Jong-Mu Sun, Mary E R O'Brien, Christian von Plessen, Fernando Barata, Keunchil Park, Sanjay Popat, Bengt Bergman, Barbara Parente, Ciro Gallo, Cesare Gridelli, Francesco Perrone, Massimo Di Maio
Journal: The Lancet Oncology (2014)
Mallory bodies in alcoholic liver disease: identification of cytoplasmic filament/cell membrane and unique antigenic determinants by monoclonal antibodies.
Authors: J A Morton, J Bastin, K A Fleming, A McMichael, J Burns, J O McGee
Journal: Gut (1981)

Polyclonal and monoclonal antibodies have been produced to Mallory body protein (MBP) extracted from isolated Mallory bodies (MBs). The polyclonal antibodies reveal a unique determinant in MBs. The first monoclonal antibody (anti-JMB1) detects a second unique determinant (JMB1) in MBs which is not detectable in normal hepatocytes. The second monoclonal antibody (anti-JMB2) shows that MBs contain another determinant which is associated with the cell and nuclear membranes and a cytoplasmic filament system of normal hepatocytes and bile duct epithelium; this antigen is not detectable in the cell membranes or cytoplasmic filament systems of hepatocytes which contain MBs. The third monoclonal antibody (anti-JMB3) reacts only with an antigen (JMB3) in mesenchymal cells of alcoholic cirrhotic liver and its significance, at this time, is unclear. It is suggested that the metabolism of JMB1, JMB2, and JMB3 antigens is deranged in hepatocytes damaged by alcohol. It is concluded that the antigenic structure of MBs is more complex than hitherto realised and that all of these antigens are distinct from prekeratin (a component of epidermal cell intermediate filaments).
Prolactin and prolactin receptors are expressed and functioning in human prostate.
Authors: M T Nevalainen, E M Valve, P M Ingleton, M Nurmi, P M Martikainen, P L Harkonen
Journal: Journal of Clinical Investigation (1997)

Prolactin is widely expressed in different tissues, and it is presumed to have both local and systemic actions. In males it is known to influence reproductive functions but the significance and mechanisms of prolactin action in male accessory reproductive tissues are poorly understood. Here we show that prolactin acts as a direct growth and differentiation factor for human prostate, as measured by changes in DNA synthesis and epithelial morphology of organ cultures. Furthermore, we report the expression in human prostate of a short prolactin receptor form in addition to the long form, based upon ligand cross-linking studies and RT-PCR analysis of mRNA expression. The highest density of prolactin receptors was detected in the secretory epithelial cells by immunohistochemistry. Finally, we report that prolactin is locally produced in human prostate epithelium, as evidenced by marked prolactin immunoreactivity in a significant portion of prostate epithelial cells, with parallel expression of prolactin mRNA in human prostate. Collectively, these data provide significant support for the existence of an autocrine/paracrine loop of prolactin in the human prostate and may shed new light on the involvement of prolactin in the etiology and progression of neoplastic growth of the prostate.
AUREOMYCIN IN THE TREATMENT OF KAPOSI'S VARICELLIFORM ERUPTION.
Authors: J. A. McCONACHIE, T. E. ANDERSON
Journal: British Journal of Dermatology (1951)

Journal Article AUREOMYCIN IN THE TREATMENT OF KAPOSI'S VARICELLIFORM ERUPTION. Get access J. A. McCONACHIE, J. A. McCONACHIE The Royal Aberdeen Hospital for Sick Children Search for other works by this author on: Oxford Academic Google Scholar T. E. ANDERSON T. E. ANDERSON The Royal Aberdeen Hospital for Sick Children Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 63, Issue 8-9, 1 August 1951, Pages 307–311, https://doi.org/10.1111/j.1365-2133.1951.tb13731.x Published: 01 August 1951
Evaluation of left ventricular contractile function using noninvasively derived end-systolic elastance in mitral regurgitation: experimental validation and clinical study
Authors: None Yong Jin Kim, Michael Jones, Takahiro Shiota, None Jian Xin Qin, Neil L. Greenberg, Zoran B. Popovic, Jun Kwan, Marta Sitges, Fabrice Bauer, Hua Yang, Lisa A. Cardon, Vandana Sachdev, Brian P. Griffin, Delos M. Cosgrove, James D. Thomas
Journal: Journal of the American College of Cardiology (2002)
The Siege of Cancer
Authors: Philip C. Anderson
Journal: JAMA (1976)

Advertised as an assessment of the prospects for a cancer cure, endorsed as a stimulating report by a leader of the American Cancer Society, and touted on the dust cover as magnificent, comprehensive, optimistic, beautifully written and unique, this journalistic endeavor cannot measure up to such rash claims. The publishers might be able to promote the book in the lay market, but the knowledgeable medical reader will find Goodfield's anecdotes far short of a comprehensive report on any cancer problem. Some of her interests in science and insights into scientists are charming, and a few are informative.  The first chapter, concerning epidemiologic studies of esophageal carcinoma in the deserts of Iran, is colorful journalism but not a penetrating analysis of this expensive and difficult research method. The more promising research concerning oncogenic viruses is more skillfully discussed but is uneven and long-winded. Somehow, the author often seems compelled to disrupt
THE IMPORTANCE OF AN EARLY DIAGNOSIS OF TUBERCULOSIS.
Authors: A. MANSFIELD HOLMES
Journal: JAMA (1901)

The failure to recognize tuberculosis in its incipiency is the result of several causes: Tuberculosis has an insidious beginning. Most patients do not recognize the nature of their trouble until a [ill] is well established, and frequently when they consult a physician the disease is well advanced. The symptoms which belong to the incipient stage are not easy of recognition and are frequently misinterpreted by the examining physician. Many patients will not accept the facts until it is too late Many physicians fail to give the facts at this stage for fear of frightening patients. These are the principal reasons why tuberculosis is frequently unrecognized until it is too late to hope for relief; and, also, furnish an explanation for the widespread belief that tuberculosis is incurable. Before beginning to discuss the subject of the early recognition of tuberculosis it seems essential that some definite method of classification should be
GlaxoSmithKline to limit payments it makes to US doctors to $150 000 a year
Authors: Z. Kmietowicz
Journal: BMJ (2008)

GlaxoSmithKline is to limit the advisory payments and honorariums it offers to doctors in the United States to $150 000 (£96 000; €120 000) a doctor a year. The company has also said that it will publish the amount of money it offers to doctors “without exception,” although doctors’ names will not be published.

Andrew Witty, chief executive of the company, told the Financial Times , “It’s appropriate that we have a limit on what we pay. In the past, whatever has happened has happened, but in the future there will be strict adherence to these caps, which will be clearer to everybody” (23 Oct, p 22).

A spokeswoman for the company said that it had no plans to introduce a cap on payments …
Human and Ecologic Effects in Massachusetts of an Assumed Thermonuclear Attack on the United States
Authors: Frank R. Ervin, John B. Glazier, Saul Aronow, David Nathan, Robert Coleman, Nicholas Avery, Stephen Shohet, Cavin Leeman
Journal: New England Journal of Medicine (1962)

IN recent months public anxiety and confusion over the possibility and consequences of thermonuclear war have been increased and deepened by extensive (and often conflicting) publicity in newspapers and popular magazines, federal and local government announcements and commercial advertising concerning shelter programs. Many people, uncertain about what course to follow, have turned to physicians to provide expert information. These requests for evaluation and plans have ranged from consideration of immediate fallout effects to the optimal design of fallout shelters, the long-term prospects of blood dyscrasias and the suggestion of modification of medical-school curriculums to meet the needs of a postholocaust . . .
New Cancer Strategies Needed For Changing Population
Authors: C. Nelson
Journal: JNCI Journal of the National Cancer Institute (1995)

Journal Article New Cancer Strategies Needed For Changing Population Get access Corinna Nelson Corinna Nelson Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 87, Issue 11, 7 June 1995, Page 793, https://doi.org/10.1093/jnci/87.11.793 Published: 07 June 1995