tbuckley/cabot-search huggingface dataset:
Positron emission tomography with [18F]fluoro-2-deoxy-D-glucose for diagnosis and staging of bile duct cancer
Authors: Regine Kluge, Frank Schmidt, Karel Caca, Henryk Barthel, Swen Hesse, Peter Georgi, Anita Seese, Dominik Huster, Frieder Berr
Journal: Hepatology (2001)

Malignant tumors with high glucose metabolic rates accumulate [18F]–fluorodeoxyglucose (FDG), a positron emitting tracer. The aim of this study was to evaluate FDG positron emission tomography (PET) for detection and staging of human cholangiocarcinoma (CC). Patients with adenocarcinoma of the biliary tree (n = 26), with benign lesions of the bile ducts (n = 8), and 20 control patients underwent FDG–PET (370 MBq [18F]–FDG, Siemens ECAT EXACT HR + ). In a blinded fashion, 4 independent experts evaluated the PET scans visually and semiquantitatively using the standardized uptake value and a tumor/non–tumor ratio. All adenocarcinomas and benign lesions (sclerosing cholangitis, bile duct adenoma, Caroli's disease) were histologically proven and imaged by magnetic resonance imaging and endoscopic retrograde cholangioscopy. True–positive PET scans were obtained in 24 of 26 CC and false–negative scans in the other 2 (sensitivity 92.3%). The PET scan was true–negative in 18 of 20 controls and in all 8 benign biliary lesions (specificity 92.9%). Visual and semiquantitative evaluation using tumor/non–tumor ratios were equally accurate (accuracy 92.6%) whereas evaluation by standardized uptake value revealed lower accuracy ( P &lt; .05). Regional or hepatoduodenal lymph node metastases were detected with PET in only 2 of 15 cases whereas distant metastases (peritoneal carcinomatosis, pulmonary metastases) were diagnosed in 7 of 10 cases. In conclusion, PET is highly sensitive and specific for the detection and localization of CC. It can be helpful for diagnosis of distant metastases but is not suitable for detection of regional lymph node metastases. (Hepatology 2001;33:1029–1035.)
WHO calls for stronger action to reduce health risks from climate change
Authors: J. Zarocostas
Journal: BMJ (2014)

<h3>Objective</h3> The aims of the study were to determine the effect of preeclampsia on bronchopulmonary dysplasia (BPD) development in preterm infants and to investigate the possible association between BPD severity and preeclampsia. <h3>Methods</h3> The study group involved preterm infants (≤32 gestational week) born to a preeclamptic mother with no co-existing medical condition, whereas the comparison group involved preterm infants born to a normotensive mother. BPD was defined as requirement for supplemental oxygen for the first 28 day of life. It was classified as mild, moderate and severe BPD. The demographics and clinical data of the infants were recorded. <h3>Results</h3> There were 117 and 215 premature infants in the study and control groups, respectively. The incidence of BPD in preterm infants in the study group (38.5%) was significantly higher than the control group (19.5%). The frequency of moderate and severe BPD were significantly higher in the study group. In logistic regression model, preeclampsia was found to be predictive of BPD. <h3>Conclusions</h3> Preeclampsia was found to be an important risk factor for BPD development in preterm infants. The incidence of both moderate and severe BPD was significantly higher in preeclamptic mother infants. These findings might be associated with altered angiogenesis in the preeclamptic mother which might be shared with the fetus.
Inflammatory tumour microenvironment is associated with superior survival in hepatocellular carcinoma patients
Authors: Valerie Chew, Charlene Tow, Marissa Teo, Hing Lok Wong, Jasmine Chan, Adam Gehring, Marie Loh, Alexandre Bolze, Richard Quek, Victor K.M. Lee, Kang Hoe Lee, Jean-Pierre Abastado, Han Chong Toh, Alessandra Nardin
Journal: Journal of Hepatology (2009)
Asthma in adults: comparison of adult‐onset asthma with childhood‐onset asthma relapsing in adulthood
Authors: C. Ségala, G. Priol, D. Soussan, R. Liard, F. Neukirch, D. Touron, T. Lepage
Journal: Allergy (2000)

The prevalence of asthma in children and young adults is rising. Although the general features of asthma are similar in children and adults, there are several differences. Studies of the differences between childhood‐ and adult‐onset asthma may provide new insight into the phenotypic heterogeneity of asthma. The aim of this cross‐sectional study was to compare the characteristics of asthmatic adults who reported having ( n =84) or not having ( n =235) asthma in childhood. The participating patients were recruited by chest specialists throughout France and were examined from March to November 1995. The specialists completed a standardized questionnaire, and carried out a clinical examination and spirometric tests. Male sex; greater severity, particularly lower spirometry values related to small airways; greater severity and earlier onset of allergy; and maternal history of atopic dermatitis and perennial rhinitis were found to be associated with reported childhood asthma. This study exhibits highly internally consistent results and indicates that subjects who did have childhood asthma and relapse in adulthood appeared to have a potentially more severe form of asthma.
Subcutaneous Glucagon May Be Better Than Oral Glucose for Prehospital Treatment of Symptomatic Hypoglycemia
Authors: Marian J. Vermeulen, Michael Klompas, Joel G. Ray, Chris Mazza, Laurie J. Morrison
Journal: Diabetes Care (2003)

The optimal management of symptomatic hypoglycemia in the prehospital setting remains uncertain, particularly in the absence of intravenous access (1,2). We performed an audit in Toronto, ON, Canada, and compared prehospital patient care outcomes following administration of oral glucose gel versus subcutaneous glucagon. For the city’s population of >2.5 million people, there is a single Emergency Medical Service system made up of both ambulance and fire services, which are directed by one base hospital.

Our study included all consecutive patients attended by primary care paramedics for symptomatic hypoglycemia, defined as a capillary glucose concentration <4.0 mmol/l (72 mg/dl). Initially, the primary care paramedics followed a …
Biophysical aspects of blood flow in the microvasculature
Authors: A.R. Pries, T.W. Secomb, P. Gaehtgens
Journal: Cardiovascular Research (1996)

The main function of the microvasculature is transport of materials. Water and solutes are carried by blood through the microvessels and exchanged, through vessel walls, with the surrounding tissues. This transport function is highly dependent on the architecture of the microvasculature and on the biophysical behavior of blood flowing through it. For example, the hydrodynamic resistance of a microvascular network, which determines the overall blood flow for a given perfusion pressure, depends on the number, size and arrangement of microvessels, the passive and active mechanisms governing their diameters, and on the apparent viscosity of blood flowing in them. Suspended elements in blood, especially red blood cells, strongly influence the apparent viscosity, which varies with several factors, including vessel diameter, hematocrit and blood flow velocity. The distribution of blood flows and red cell fluxes within a network, which influences the spatial pattern of mass transport, is determined by the mechanics of red cell motion in individual diverging bifurcations. Here, our current understanding of the biophysical processes governing blood flow in the microvasculature is reviewed, and some directions for future research are indicated.
SUBACUTE HYPODERMIC NODULES OE VASCULAR ORIGIN.
Authors: J. HEWITT
Journal: British Journal of Dermatology (1957)

Journal Article SUBACUTE HYPODERMIC NODULES OE VASCULAR ORIGIN. Get access J. HEWITT J. HEWITT Paris Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 69, Issue 7-8, 1 July 1957, Pages 245–250, https://doi.org/10.1111/j.1365-2133.1957.tb13264.x Published: 01 July 1957
Liver Metastasis of Colon Adenocarcinoma Demonstrated on 99mTc-Pyrophosphate Bone Scan
Authors: JEFFREY S. STEVENS, EDGAR E. CLARK
Journal: Clinical Nuclear Medicine (1977)

A liver metastasis of a colon adenocarcinoma that contained collagen but no gross or microscopic calcification accumulated 99mTc-pyrophosphate during a bone scan. This represents in vivo support for in vitro data showing binding of pyrophosphate by collagen, and suggests a possible mechanism for labeling of noncalcified tumors by 99mTc-pyrophosphate.
A global health equity agenda for the G8 summit
Authors: Ronald Labonte, Ted Schrecker, Amit Sen Gupta
Journal: BMJ (2005)

Learning from other healthcare systems is not straightforward, but all systems face the same fundamental problems of quality, safety, access, usability, availability, and affordability-and all perform suboptimally.We see increasing examples of interaction and learning among systems.Such learning will benefit patients.Contributors and sources: LQ was a Rhodes scholar in Oxford and is now the chief executive of Ovations, which provides serv-
Omeprazole, H2 blockers, and polyarthralgia: case-control study
Authors: C. R Meier, H. Jick
Journal: BMJ (1997)

Acute polyarthralgia has been reported in five patients in association with the proton pump inhibitor omeprazole. 1 These patients did not have rheumatoid arthritis, concurrent infections, or connective tissue disorders, and their symptoms resolved after stopping omeprazole. 1 We compared the relative risk of developing acute idiopathic polyarthralgia during and after exposure to omeprazole, ranitidine, or cimetidine, antiulcer drugs used for similar indications.
SIMPLE DEVICE FOR BLADDER DECOMPRESSION
Authors: William S. Ehrich
Journal: JAMA (1924)

There is no question regarding the propriety of gradual decompression in overdistended bladders, especially in those in which the distention is due to prostatic obstruction and is probably of long duration. There have been some very serviceable devices made for this purpose, but all are more or less complicated and expensive. I therefore present this little apparatus, which, I think, combines serviceability, ease of construction, and low cost. In fact, it can be constructed with the materials found on an ordinary rectal drip. An indwelling catheter is inserted and secured, and is connected with a tube about 4 or 5 feet long, so that the patient may have ample ease of movement. The end of this tube is raised and lowered until the height of the urine pressure is ascertained. This tube is then connected with a bent tube of either glass or hard rubber, which is hung over the
A relation between gastroduodenal muscle contractions and gastric empyting.
Authors: N W Weisbrodt, J N Wiley, B F Overholt, P Bass
Journal: Gut (1969)

lowing an 18-hour fast, the animal's stomach was washed with 100 ml distilled water instilled through a tube placed in the stomach via the oesophageal cannula.This procedure evoked a burst type pattern of contractile activity 543 on August 20,
Distribution, virulence-associated genes and antimicrobial resistance of Aeromonas isolates from diarrheal patients and water, China
Authors: Fengjuan Li, Wenqing Wang, Zhaoqin Zhu, Aiping Chen, Pengcheng Du, Ruibai Wang, Haili Chen, Yunwen Hu, Jie Li, Biao Kan, Duochun Wang
Journal: Journal of Infection (2014)
Carbon Monoxide Orchestrates a Protective Response through PPARγ
Authors: Martin Bilban, Fritz H. Bach, Sherrie L. Otterbein, Emeka Ifedigbo, Joana de Costa d'Avila, Harald Esterbauer, Beek Yoke Chin, Anny Usheva, Simon C. Robson, Oswald Wagner, Leo E. Otterbein
Journal: Immunity (2006)
Anabolic Steroids and Muscle Strength
Authors: Stephen R. Plymate, Karl E. Friedl
Journal: Annals of Internal Medicine (1992)

Letters1 February 1992Anabolic Steroids and Muscle StrengthStephen R. Plymate, MD, Karl E. Friedl, PhDStephen R. Plymate, MDSearch for more papers by this author, Karl E. Friedl, PhDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-116-3-270 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors:The article by Elashoff and colleagues (1) provided a comprehensive assessment of the status of our current knowledge of the possible effects of androgens on muscular strength. In addition to the numerous deficiencies of the reported studies noted by Elashoff, we point out that none of the studies provided any measurement of the steroid levels obtained in blood or tissue. This factor may result from the difficulty of measuring in serum the variety of anabolic agents taken by athletes. However, considering the multiple routes of androgen metabolism it is difficult to determine an androgen response without some...References1. ElashoffJacknowShainBraunstein JASG. Effects of anabolicandrogenic steroids on muscular strength. Ann Intern Med. 1991;115: 387-93. LinkGoogle Scholar2. FriedlJonesHannanPlymate KRCS. The administration of pharmacological doses of testosterone or 19-nortestosterone to normal men is not associated with increased insulin secretion or impaired glucose tolerance. J Clin Endocrinol Metab. 1989;68:971-5. CrossrefMedlineGoogle Scholar3. HortonHawksLobo RDR. 3-Alpha, 17-beta-androstanediol glucuronide in plasma: a marker of androgen action in normal healthy Caucasian versus Chinese subjects. J Clin Invest. 1982;69:1203-6. CrossrefMedlineGoogle Scholar4. LookingbillDemersWangLeungRittmasterSanten DLCARR. Clinical and biochemical parameters of androgen action in normal healthy Caucasian versus Chinese subjects. J Clin Endocrinol Metab. 1991;72:1242-8. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Stephen R. Plymate, MD; Karl E. Friedl, PhDAffiliations: U.S. Army Research Institute of Environmental Medicine Natick, MA 01760 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAnabolic SteroidsTesting for anabolic steroids in hair from two bodybuildersNutrition, Anabolic Steroids, and Growth Hormone 1 February 1992Volume 116, Issue 3Page: 270-270KeywordsAndrogensBloodMusclesSteroids ePublished: 1 December 2008 Issue Published: 1 February 1992 PDF downloadLoading ...
Recognizing Maltose-induced Hyponatremia
Authors: Paul M. Palevsky
Journal: Annals of Internal Medicine (1994)

Letters1 February 1994Recognizing Maltose-induced HyponatremiaPaul M. Palevsky, MDPaul M. Palevsky, MDUniversity of Pitts burgh School of Medicine; Pittsburgh, PA 15213Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-3-199402010-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:I strongly agree that it is important for clinicians to distinguish maltose-induced hyponatremia from hypotonic hyponatremia [1]. The absence of central nervous system toxicity may be an important clinical finding pointing away from hypotonic hyponatremia. Unfortunately, our patient had an altered mental status before the onset of hyponatremia and was intermittently receiving doses of sedatives. Thus, her mental status was not a valid measure of the presence or absence of transcellular shifts in central nervous system fluid.The cause of our patient's hyponatremia was initially unclear. No serum sodium concentration was measured immediately after the first infusion of ...REFERENCE1. Palevsky PM, Rendulic D, Diven WF. Maltose-induced hyponatremia. Ann Intern Med. 1993; 118:526-8. Google Scholar Author, Article, and Disclosure InformationAuthors: Paul M. Palevsky, MDAffiliations: University of Pitts burgh School of Medicine; Pittsburgh, PA 15213 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1994Volume 120, Issue 3Page: 248-249KeywordsAttentionCentral nervous systemGlobulinsHyponatremiaHypotonicityImmune serumResearch laboratoriesSedativesSodiumToxicity ePublished: 15 August 2000 Issue Published: 1 February 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Medical treatment of bleeding peptic ulcer: old drugs, new regimens.
Authors: A Arora, R K Tandon
Journal: Gut (1991)

recruited as three volunteers from the first set of experiments were not happy to swallow an intraduodenal tube.Fluctuations in basal SMABF between different test days do, in our review, reflect acceptable physiological variations.As all determinations were performed by the same investigator (CS), the fluctuations cannot be attributed to an interobserver variabiality.(3) We have measured postprandial secretin, cholecystokinin, and gastrin concentrations for many years.8-'0We did not measure these in the present study, because we felt that the plasma concentrations did not add any new pertinent information.We acknowledge the references stated with regard to glucagon values found postprandially.Even if the glucagon dose employed induced an increase at the upper limit of physiological glucagon concentrations, we still believe that our conclusions are valid and this is underlined by the lack of change in SMABF observed in our study with this dose of glucagon.We cannot comment on the unpublished data discussed in the letter, as they are not available yet.In summary, we have presented data on specific mechanisms regulating postprandial mesenteric artery blood flow using the echo- Doppler flowmetry.Quantitative studies of postprandial hyperaemia are important for the understanding of normal physiological processes.We therefore hope that future research by various groups (as the group of Dr Wells) will be able to shed more light into the physiology and pathophysiology of intestinal blood flow regulation.
Complement-mediated phagocytosis in rheumatoid vasculitis
Authors: N P Hurst, G Nuki
Journal: BMJ (1981)

British National Formulary 1981 on p 150- not p 159 as misprinted in Dr Finch's letter) is that prophylaxis with sulphonamides is indicated only for known sulphonamidesensitive strains.This is emphasised in the article by Jones and Abbott2 (the actual drug to be used for chemoprophylaxis is not mentioned in the paper by De Wal et a13 quoted by Dr Finch and Mr Gilbey).Jones and Abbott note the high prevalence of sulphonamide resistance in group A strains and the 20-25 ( ' , resistance found in other sero-
Oral psoralen photochemotherapy (PUVA) of hyperkeratotic dermatitis of the palms
Authors: H. MOBACKEN, K. ROSEN, G. SWANBECK
Journal: British Journal of Dermatology (1983)

Oral psoralen photochemotherapy (PUVA) was found to be effective in five patients with chronic hyperkeratotic dermatitis of the palms. Relapses may occur but they respond well to retreatment.
Efficient gene transfer into mouse embryonic stem cells with adenovirus vectors
Authors: Kenji Kawabata, Fuminori Sakurai, Teruhide Yamaguchi, Takao Hayakawa, Hiroyuki Mizuguchi
Journal: Molecular Therapy (2005)

Efficient and transient gene transfer into embryonic stem (ES) cells is expected to be of use for basic studies in developmental biology and for applications in regenerative medicine. Here, we report the development of an adenovirus (Ad) vector that efficiently expresses foreign genes in mouse ES (mES) cells. We prepared four LacZ-expressing Ad vectors, each of which contained one of the following: Rous sarcoma virus (RSV), cytomegalovirus (CMV), β-actin promoter/CMV enhancer (CA), or EF-1α promoter. While the RSV and CMV promoters were inactive in mES cells, the CA and EF-1α promoters strongly drove LacZ expression in more than 90% of the mES cells. The EF-1α promoter was found to be slightly more efficient than the CA promoter. mES cells were found to express the Ad primary receptor, coxsackievirus and adenovirus receptor, suggesting that while Ad vectors could introduce the exogenous gene into mES cells, the choice of a suitable promoter was critical for efficient gene expression. Fiber-mutant Ad vectors containing RGD or polylysine peptide on the fiber knob mediated efficient LacZ expression, not only in mES cells, but also in feeder cells. Exogenous expression of Oct-3/4 or the dominant-negative mutant of STAT3 (STAT3F) by conventional Ad vectors containing the EF-1α promoter promoted the differentiation of mES cells into the cells of three germ layers, and STAT3F-mediated differentiation was rescued by the coexpression of Nanog. These results suggest that Ad vectors can be used for basic research using ES cells and that they may be of great utility for therapeutic applications in gene-modified regenerative medicine based on ES cells.
Status of patients 5 or more years after correction of coarctation of the aorta over age 1 year.
Authors: M M Hubbell, R G O'Brien, L J Krovetz, H P Mauck, D G Tompkins
Journal: Circulation (1979)

In this retrospective study, we reviewed the records of patients who had coarctectomies at the University of Virginia Hospital after 1 year of age. Follow-up data for 5 years or more after surgery were available for 52 patients. Data from 23 similar patients from the Medical College of Virginia brought the total postoperative sample size to 75. The blood pressure of this group of patients did not differ significantly from that of the population at large. We conclude that successful repair of coarctation of the aorta in childhood or early adolescence does not lead to a higher-than-expected incidence of resting hypertension in childhood.
Maternal and fetal outcome in Swedish women with erythropoietic protoporphyria
Authors: S. Wahlin, H.-U. Marschall, B. Fischler
Journal: British Journal of Dermatology (2013)

Painful photosensitivity is characteristic of erythropoietic protoporphyria (EPP). In women, symptoms may be affected by menstrual cycle and pregnancy but very little is known about maternal and fetal outcome. To investigate the impact of menstruation, pregnancy and breast‐feeding on photosensitivity and possible effects of EPP on maternal, fetal and neonatal outcome. Retrospective study screening all 20 Swedish women alive and older than 18 years diagnosed with EPP with a total of 33 deliveries. Data were retrieved for 19 women and 32 deliveries in medical records and completed by a questionnaire sent to the patients. Photosensitivity worsened in five of 19 (26%) women around menstruation whereas amelioration was reported in 17 of 32 (53%) pregnancies and during 11 of 32 (34%) breast‐feeding periods. Fertility rate was normal and there were no maternal or fetal complications apart from minor arterial hypertension in one woman. The study confirms changes in photosensitivity during menstruation and pregnancy. Amelioration during breast‐feeding is a new finding. Pregnancy appears safe without increased risks of pregnancy complications or adverse effects on fetal or neonatal health.