tbuckley/cabot-search huggingface dataset:
Environmental pollutants in relation to complications of pregnancy.
Authors: S Tabacova, L Balabaeva
Journal: Environmental Health Perspectives (1993)

Certain complications of pregnancy, e.g., threatened spontaneous abortion, toxemia, emesis, and anemia, were studied in pregnant women living in industrial areas contaminated by smelters and the petrochemical industry. Exposure to lead or aromatic hydrocarbons was assessed in parallel by the determination of these agents or their metabolites in blood and urine. Comparison of respective exposure levels was made between women with normal pregnancies and those with complications. Significantly higher levels of lead in blood and increased excretion of the metabolic products of organic solvents were found in women with complicated pregnancies compared to those with normal pregnancies. Threatened spontaneous abortion, toxemia, and anemia were associated with higher lead exposure in the vicinity of smelters. In these patients, evidence of disturbances of blood glutathione equilibrium and increased lipid peroxidation were found indicating a decreased ability to compensate for the effects of exposure. Styrene exposure in a petrochemical industrial area was associated mainly with late toxemia and nephropathy. Patients with these complications also had a tendency to elevated exposure to other aromatic hydrocarbons. It is suggested that complications of pregnancy may be induced by environmental agents at levels lower than those that result in pregnancy loss or preterm birth.
Breast cancer molecular subtypes and the risk of second malignancies.
Authors: B Radecka, J Hudala-Klecha, A Badzio, M Szwiec, K Drosik, J Jassem
Journal: Cancer Research (2009)

Abstract Abstract #1078 Background: Particular molecular subtypes of breast cancer (BC) have been shown to manifest various clinical behaviors. In a large consecutive series of pts we compared treatment outcomes of four major BC subtypes, with particular focus on the risk of second malignancies.&amp;#x2028; Materials and methods: Triple negative breast cancer (TNBC) was characterized by negativity of hormone receptors (HR) and HER2 (0-2+ by immunohistochemistry). Other subtypes included HR+/HER2-, HR+ /HER2+ and HR-/HER2+. All pts underwent curative surgery from January 2003 to December 2007, followed by radiation and/or systemic therapy according to current standards. Univariate risks of relapse and death were estimated using Kaplan-Meier survival curves and compared with log-rank test, and the multivariate analysis used stratified Cox model.&amp;#x2028; Results: Of the 783 tumors, 520, 50, 48 and 165 were classified as HR+/HER2-, HR+ /HER2+, HR-/HER2+ and TNBC, respectively. The TNBC and HR-/HER2+ subtypes were associated with a higher tumor grade (p&amp;lt;0.001), higher T stage (p&amp;lt;0.001) and higher proportion of medullary type (p&amp;lt;0.001) compared to other two subgroups. Other characteristics, such as age and menopausal status showed no difference. The probability of relapse-free survival (RFS) and overall survival (OS) in TNBC and HR-/HER2+ groups were similar, and lower than in other two types (TNBC vs. HR+/HER2- and HR+ /HER2+; p=0.002 and 0.03 for RFS and OS). Impaired prognosis of TNBC and HR-/HER2+ pts remained significant after correction by T and N stage. TNBC was associated with almost doubled risk of second malignancy (12.7 vs. 6.5%) compared to all other types (p=0.008). This risk was significantly increased for contralateral BC and endometrial cancer (p=0.002 and 0.024, respectively).&amp;#x2028; Conclusion: TNBC and HR-/HER2+ subtypes are associated with worse prognosis. Additionally, TNBC carries an increased risk of second malignancies, most likely due to higher proportion of hereditary BC. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 1078.
Is sclerotherapy the first choice treatment for active oesophageal variceal bleeding in cirrhotic patients? Final report of a randomized controlled trial
Authors: P. Alexandrino, M.M. Alves, P. Fidalgo, L. Matos, A.V. Esteves, J. Veloso, A.G. Oliveira, M.C. Moura
Journal: Journal of Hepatology (1990)
THE NEED OF MEDICAL COOPERATION IN LABORATORY WORK.ADDRESS OF CHAIRMAN OF THE SECTION ON PATHOLOGY AND PHYSIOLOGY, AT THE FIFTY-EIGHTH ANNUAL SESSION OF THE AMERICAN MEDICAL ASSOCIATION AT ATLANTIC CITY, JUNE, 1907.
Authors: WALTER L. BIERRING
Journal: JAMA (1907)

In accordance with past precedent and the dictates of our program, it is my privilege to say a few words of greeting, and I take this opportunity to express my appreciation of the honor accorded me in the selection as chairman of this Section. It is particularly gratifying to the Section to have as its guest for this meeting Prof. J. George Adami of Montreal, and I extend to him herewith on behalf of the Section a most cordial welcome.  As we meet here in the city by the sea it seems fitting to recall that this is the birthplace of the Section. In the seven years since its organization we have met in St. Paul, Saratoga, New Orleans, Atlantic City, in far away Portland, in Boston, and again in the city of its birth.  To those who have labored for the Section's welfare it should be a source of
Diagnosis-Related Groups and Severity
Authors: Robert L. Mullin
Journal: JAMA (1985)

A GREAT deal has been written in the medical literature, the hospital industry literature, and the press about the insensitivity of the diagnosis-related groups (DRGs) to severity of illness.<sup>1</sup>This statement has even come from the Congress of the United States. <h3>Medisgrps Severity Classification</h3> An article titled "Review System Based on Illness Severity" recently appeared in<i>American Medical News</i>.<sup>2</sup>It describes the Medisgrps severity classification definitions. The article states: "At admission, Medisgrps assigns a patient to one of five severity groups, and then compares that severity with severity at a later date, typically 10 days after admission or six days after surgery." Since the average length of stay of Medicare patients is now under 8.8 days and non-Medicare patients under 5.6 days, a majority of the patients will be discharged before this second severity assignment. The table concerning DRG 122 appearing in the article is reproduced herein, with
Abstract LB-342: Matrix metalloproteinase-9 is a novel pathogenic factor in B-cell chronic lymphocytic leukemia
Authors: Javier Redondo-Muñoz, Estefanía Ugarte-Berzal, María-José Terol, Philippe E. Van den Steen, Mercedes Hernández del Cerro, Martin Roderfeld, Elke Roeb, Ghislain Opdenakker, José A. García-Marco, Angeles García-Pardo
Journal: Cancer Research (2010)

Abstract B-cell chronic lymphocytic leukemia (B-CLL) is characterized by the accumulation in peripheral blood of CD5+ B lymphocytes, which ‘ progressively infiltrate lymphoid tissues. Several molecules, including matrix metalloproteinase-9 (MMP-9), are involved in these processes and could represent therapeutic targets. We previously showed that MMP-9 plays an essential role in B-CLL cell migration through basement membranes or endothelial cells (Redondo-Muñoz et al., Blood 108: 3143, 2006). We also recently demonstrated that alpha4beta1 integrin and a 190 kDa CD44v isoform are receptors for MMP-9 in B-CLL but not in normal B cells and that the MMP-9 hemopexin domain is essential for these interactions. Binding of MMP-9 to B-CLL cells inhibited cell migration and this required MMP-9 proteolytic activity (Redondo-Muñoz et al., Blood 112: 169, 2008). To further define the role of surface-bound MMP-9 in B-CLL we have employed several techniques including western blot, zymography, immunofluorescence, immunoprecipitation, siRNA transfection, cell adhesion/soluble binding assays, apoptosis, and cell migration assays. B-CLL cells cultured on pro- or mature MMP-9, proMMP-9 hemopexin domain or proMMP-9 catalytically-inactive mutant, showed decreased spontaneous apoptosis. This was due to induction of a survival pathway involving Lyn activation, STAT3 phosphorylation and Mcl-1 upregulation and did not require catalytic activity. This pathway was induced in all B-CLL cases and was active in B-CLL lymphoid tissues. Our results highlight the role of MMP-9 in B-CLL pathogenesis and indicate that MMP-9 hemopexin domain could constitute a therapeutic target in this malignancy. Supported by grants PI060400 and SAF2009-07035 from the Ministerio de Ciencia e Innovación and by the Fundación de Investigación Médica Mutua Madrileña. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr LB-342.
Incidence and prognostic impact of c-Kit, FLT3, and Ras gene mutations in core binding factor acute myeloid leukemia (CBF-AML)
Authors: N Boissel, H Leroy, B Brethon, N Philippe, S de Botton, A Auvrignon, E Raffoux, T Leblanc, X Thomas, O Hermine, B Quesnel, A Baruchel, G Leverger, H Dombret, C Preudhomme
Journal: Leukemia (2006)
Self-Monitoring of Blood Glucose During Pregnancy in Women with Juvenile Diabetes
Authors: Moshe Karp, Zipora Flexer, Gila Faiman, Eithan Topper, Hana Neeman, Zvi Laron
Journal: Diabetes Care (1980)

Eight pregnant patients with insulin-dependent juvenile diabetes were persuaded to start self-monitoring of blood glucose between the 10th to the 20th week of gestation. One patient with two children discontinued this effort after a short period. Four patients are still on a regimen of self-monitoring during their pregnancy, and three have delivered normal infants. The latter three patients were all able to achieve almost normal blood glucose levels during the pregnancies. These observations, in addition to those of others, lead to the conclusion that self-monitoring of blood glucose can be an useful tool in the management of diabetes, particularly in pregnant women, who have a high degree of motivation to achieve good Control.
Hepatobiliary Scan with Delayed Gallbladder Visualization in a Case of Acute Appendicitis
Authors: RALPH L. SMATHERS, P KENT HARMAN, HAROLD J. WANEBO, MARC E. READ
Journal: Clinical Nuclear Medicine (1982)

A 40-year-old woman presented with acute epigastric pain with vomiting. Within 24 hours, the pain spread to the right periumbilical region. Tc-99m disofenin hepatobiliary scan failed to demonstrate the gallbladder on a 60-minute view. The presumative diagnosis of acute cholecystitis was thought to be confirmed on this basis by the patient's physicians. However, a 75-minute view demonstrated filling of the gallbladder. In hepatobiliary scanning for acute abdominal pain, delayed views (2 to 24 hours) are recommended when the gallbladder is not visualized on the 60-minute view. If the gallbladder is visualized, cystic duct obstruction can be excluded and diagnoses such as pancreatitis, acalculous cholecystitis, and acute appendicitis should be investigated.
Proinsulin radioimmunoassay in the evaluation of insulinomas and familial hyperproinsulinemia
Authors: Robert M. Cohen, Bruce D. Given, Julio Licinio-Paixao, Sally A. Provow, Paul A. Rue, Bruce H. Frank, Mary A. Root, Kenneth S. Polonsky, Howard S. Tager, Arthur H. Rubenstein
Journal: Metabolism (1986)
Orthopaedic Surgery in Infancy and Childhood
Authors: Jonathan Cohen
Journal: JAMA (1975)

This book, originally published in 1957, is now in its fourth edition. It was then the first textbook of pediatric orthopedic surgery in English, and for some years it remained unchallenged, although now two other texts, those of Sharrard and Tachdjian, are worthy competitors. The present edition represents major changes over the last in that ten contributing authors have been enlisted, and substantial additions have been made in several portions, eg, developmental anatomy, prosthetics, treatment of scoliosis, and pictorialization of operative techniques. The original organization of the book is maintained: it is primarily regional, with chapters on the foot, the knee, the spine, etc. There are six such anatomical divisions. Six other chapters treat muscular affections, neurological disease, congenital diseases, tumors, infections, and metabolic diseases. The three remaining chapters—one on orthopedic treatment, including consideration of developmental anatomy, disturbances in limb formation, etc; one on the epiphyseal, metaphyseal and diaphyseal affections,
Nitric oxide donors stimulate bile flow and glutathione disulfide excretion independent of guanosine 3?,5?-cyclic monophosphate in the isolated perfused rat liver
Authors: M Trauner, M H Nathanson, A Mennone, S A Rydberg, J L Boyer
Journal: Hepatology (1997)

ABSTRACT Nitric oxide (NO) modulates several metabolic functions in hepatocytes, but the role of NO in bile secretion has not been clearly defined. In the present study, we examined the effects of NO on bile flow and biliary HCO3 - and glutathione excretion in the isolated perfused rat liver and assessed the role of guanosine 3′,5′–cyclic monophosphate (cGMP) in mediating these effects. The NO donors sodium nitroprusside (SNP) and S–nitroso–acetyl–penicillamine stimulated bile flow and increased both HCO3 - and glutathione excretion. Increases in bile flow were linearly related to increases in biliary glutathione concentration and output ( P &lt; .0001), which were almost entirely caused by glutathione disulfide, whereas the excretion of reduced glutathione remained unchanged. NO donors increased cGMP concentrations in bile and perfusate, and the membrane–permeant cGMP analogue dibutyryl cGMP was also found to stimulate bile flow and HCO3 - excretion. However, in contrast to the NO donors, dibutyryl cGMP did not increase glutathione excretion. Furthermore, the NO donors failed to stimulate bile flow in mutant TR–rats in which the canalicular transport of glutathione and glutathione conjugates is deficient, although dibutyryl cGMP increased bile flow and HCO3 - excretion in the mutant rats as in normals. These findings indicate that exogenous sources of NO increase bile acid–independent bile flow by stimulating glutathione disulfide excretion, effects that are independent of cGMP.
Tigecycline in the treatment of infections from multi-drug resistant gram-negative pathogens
Authors: Garyphallia Poulakou, Flora V. Kontopidou, Elisabeth Paramythiotou, Maria Kompoti, Maria Katsiari, Efstratios Mainas, Chara Nicolaou, Dimitrios Yphantis, Anastasia Antoniadou, Eleftheria Trikka-Graphakos, Zoi Roussou, Phyllis Clouva, Nina Maguina, Kyriaki Kanellakopoulou, Apostolos Armaganidis, Helen Giamarellou
Journal: Journal of Infection (2009)
The <i>miR-17-92</i> microRNA Polycistron Regulates <i>MLL</i> Leukemia Stem Cell Potential by Modulating p21 Expression
Authors: Piu Wong, Masayuki Iwasaki, Tim C.P. Somervaille, Francesca Ficara, Christine Carico, Christopher Arnold, Chang-Zheng Chen, Michael L. Cleary
Journal: Cancer Research (2010)

Abstract Despite advances in defining the critical molecular determinants for leukemia stem cell (LSC) generation and maintenance, little is known about the roles of microRNAs in LSC biology. Here, we identify microRNAs that are differentially expressed in LSC-enriched cell fractions (c-kit+) in a mouse model of MLL leukemia. Members of the miR-17 family were notably more abundant in LSCs compared with their normal counterpart granulocyte-macrophage progenitors and myeloblast precursors. Expression of miR-17 family microRNAs was substantially reduced concomitant with leukemia cell differentiation and loss of self-renewal, whereas forced expression of a polycistron construct encoding miR-17-19b miRNAs significantly shortened the latency for MLL leukemia development. Leukemias expressing increased levels of the miR-17-19b construct displayed a higher frequency of LSCs, more stringent block of differentiation, and enhanced proliferation associated with reduced expression of p21, a cyclin-dependent kinase inhibitor previously implicated as a direct target of miR-17 microRNAs. Knockdown of p21 in MLL-transformed cells phenocopied the overexpression of the miR-17 polycistron, including a significant decrease in leukemia latency, validating p21 as a biologically relevant and direct in vivo target of the miR-17 polycistron in MLL leukemia. Expression of c-myc, a crucial upstream regulator of the miR-17 polycistron, correlated with miR-17-92 levels, enhanced self-renewal, and LSC potential. Thus, microRNAs quantitatively regulate LSC self-renewal in MLL-associated leukemia in part by modulating the expression of p21, a known regulator of normal stem cell function. Cancer Res; 70(9); 3833–42. ©2010 AACR.
Routine Depression Screening Advised for Patients With Coronary Heart Disease
Authors: Mike Mitka
Journal: JAMA (2008)

cology and therapeutics. Instead, they should try other effective therapies. For example, acetaminophen or ibuprofen may be helpful for children who are achy or feverish, and humidification can provide relief for children with stuffy noses or coughs. Hennessy noted that while parents may find it reassuring to offer some kind of intervention when their child has a cold, a feeling that may be influenced by marketing of children’s cold medicines, colds will eventually go away on their own, so no medication is necessary. “People tend to be too quick to give kids medications for self-limiting conditions,” he said.
Liposomal formulations of Etoposide and Docetaxel for p53 mediated enhanced cytotoxicity in lung cancer cell lines
Authors: Kaustubh A. Jinturkar, Chakkumkal Anish, Mukesh K. Kumar, Tamishraha Bagchi, Amulya K. Panda, Ambikanandan R. Misra
Journal: Biomaterials (2011)
Decreased proportion of type I myofibers in skeletal muscle of dogs with chronic heart failure.
Authors: H N Sabbah, F Hansen-Smith, V G Sharov, T Kono, M Lesch, P J Gengo, R P Steffen, T B Levine, S Goldstein
Journal: Circulation (1993)

Whether biochemical and histological abnormalities of skeletal muscle (SM) develop in patients with chronic heart failure (HF) remains controversial. In the present study, dogs with chronic HF were used to examine potential alterations of SM fiber type, fiber size, number of capillaries per fiber (C/F), beta-adrenergic receptor density (Bmax), and fiber ultrastructural integrity.HF was produced in 17 dogs by sequential intracoronary microembolizations. Biopsies of the lateral head of the triceps muscle were used in all studies. Type I and type II fibers were differentiated by myofibrillar ATPase (pH 9.4 or 4.2). Bmax was assessed by radioligand binding and SM ultrastructure by transmission electron microscopy. Comparisons were made with biopsies obtained from nine control dogs. The percentage of SM type I fibers was reduced in HF dogs compared with control dogs (19 +/- 2% versus 32 +/- 5%) (p < 0.001), whereas the percentage of SM type II fibers was increased (81 +/- 2% versus 68 +/- 5%) (p < 0.001). The change in fiber type composition was not associated with a preferential atrophy or hypertrophy of either fiber type. There was no difference in SM Bmax (198.9 +/- 14.3 versus 186.8 +/- 17.3 fmol/mg protein) or in C/F (5.37 +/- 0.26 versus 5.84 +/- 0.21) between HF dogs and control dogs. No ultrastructural abnormalities were present in SM fibers of HF dogs.In dogs with HF, there is a decrease in the relative composition of the slow-twitch type I SM fibers and an increase in fast-twitch type II fibers. The shift in fiber type composition is not associated with preferential atrophy of either fiber type or with a reduction in C/F, beta-adrenergic receptor density, or structural abnormalities of the myofibers.
Circadian rhythm in pain, stiffness, and manual dexterity in rheumatoid arthritis: relation between discomfort and disability.
Authors: N Bellamy, R B Sothern, J Campbell, W W Buchanan
Journal: Annals of the Rheumatic Diseases (1991)

Fourteen patients with rheumatoid arthritis (RA) self rated their pain and stiffness on separate 10 cm visual analogue scales and performed bead intubation coordinometry (BIC) on six occasions each day for seven consecutive days. In addition, 14 healthy controls matched for age and sex also performed BIC measurements according to the same schedule. Data were analysed using least squares and cosine vector techniques. Significant circadian rhythms in patients with RA were detected in pain, stiffness, and BIC, and in controls in BIC. Pain was least in patients with RA at 1700 and stiffness at 1724. Peak BIC performance occurred almost simultaneously in RA (1544) and control (1528) subjects and for subjects with RA occurred within the 95% confidence interval of least pain and stiffness. These data suggest that the inferior performance of subjects with RA may be an accentuation of the normal physiological variation seen in healthy controls, but may be modulated by the patient9s level of pain or stiffness, or both.
TCT-6 Positive T-wave Amplitude In Lead AVR As A Predictor For A Higher Rate Of In-hospital Coronary Artery Bypass Graft In Patients With Non-ST Elevation Myocardial Infarction
Authors: Akihiro Kobayashi, Naoki Misumida, Yumiko Kanei
Journal: Journal of the American College of Cardiology (2014)
Total Correction of Transposition of the Great Arteries Following Balloon Atrioseptostomy
Authors: J. A. WALDHAUSEN, W. S. PIERCE, W. J. RASHKIND, W. W. MILLER, S. FRIEDMAN
Journal: Circulation (1970)

Twelve patients with isolated d-TGA have undergone total correction by an interatrial baffle technique. Ten of these patients had been palliated in infancy by the BAS technique, while two patients had atrial septectomy by the Blalock-Hanlon technique. Operation was facilitated if the patient had not had a previous thoracotomy. All patients survived operation and were discharged from the hospital considerably improved. While the mean preoperative arterial oxygen tension in room air bad been 27 mm Hg, the mean postoperative tension in room air was 49 mm Hg ( P &lt; 0.001). The most common complications were fluid retention, treated with diuretics, and arrhythmias, which in most instances were not of clinical importance. All patients eventually had an atrial pacemaker with normal atrioventricular conduction. Six patients had life-threatening complications, which included technical complications resulting in a late death, one case of postoperative intrathoracic bleeding, six pulmonary complications, two infections, one low cardiac output syndrome, one stroke, and one bleeding ulcer. All patients except one have done well since discharge, as evidenced by weight gain and further increase in arterial oxygen tension (mean 67 mm Hg). The use of the BAS technique as the sole method of palliation for TGA, combined with several technical modifications of baffle placement, have minimized postoperative complications and provided excellent results.