tbuckley/cabot-search huggingface dataset:
American College of Physicians Distinguished Teacher Award Lecture: Medical Education and Practice.
Authors: Eugene A. Stead
Journal: Annals of Internal Medicine (1969)

s1 May 1969American College of Physicians Distinguished Teacher Award Lecture: Medical Education and Practice.Eugene A. Stead Jr., M.D., F.A.C.P.Eugene A. Stead Jr., M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-70-5-1059_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptEducational units convert green manpower into professionally competent manpower. They are involved in service and research to the degree that these functions are useful in the educational process. Conversion of the raw manpower into skilled manpower is an inefficient process in terms of production of services or new information. The educational units are efficient producers of manpower but inefficient producers of services.Community hospitals are designed to give services with trained manpower. Whenever they try to become prime converters of manpower, they become inefficient producers of service. New categories of trained manpower should be produced by the educational system to... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Eugene A. SteadJr., M.D., F.A.C.P.Affiliations: North Carolina PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1969Volume 70, Issue 5Page: 1059-1059KeywordsMedical education ePublished: 1 December 2008 Issue Published: 1 May 1969 PDF downloadLoading ...
AEROTHERAPY AND SOLAR THERAPY IN THE HOME TREATMENT OF TUBERCULOSIS.WITH DESCRIPTION OF A WINDOW TENT.
Authors: S. A. KNOPF
Journal: JAMA (1907)

As the most important threapeutic factor in the modern management of tuberculosis, we must consider fresh and pure air, and we can make the home treatment most successful when we imitate, so far as practicable, all the salient features of the sanatorium treatment. In these institutions the patients live outdoors virtually for twenty-four hours of the day. Let us now see how we can imitate this aerotherapy of the sanatorium treatment in the home of the patient. In summer, of course, all the windows are open, and during the day we place our patients in the yard, on the veranda or on the roof, whenever and wherever conditions permit us to have the patient take what is known as the rest cure in the open air. Here he rests on a reclining chair with a proper knee bend and comfortable back. If the patient can afford it we get him
The Nephrotic Syndrome: A Complication of Massive Obesity
Authors: JOSÉ R. WEISINGER
Journal: Annals of Internal Medicine (1974)

Four patients with massive obesity and the nephrotic syndrome were studied. Congestive heart failure was not clinically apparent, and measured cardiac output was elevated; however, right atrial pressure and blood volume were increased. In each case the proteinuria decreased during dietary weight loss. Reductions in right atrial pressure and blood volume also coincided with remission in proteinuria. A mesangial glomerulopathy was present in two patients. We propose that the cause of the reversible proteinuria seen in these obese patients was renal venous hypertension.
The Study of Human Aggression
Authors: J.J. Groen
Journal: Psychotherapy and Psychosomatics (1972)

Motion pictures taken during aggressive interactions allow the researcher to repeat his observations and make them available to others. The present movie was taken during a «brawl» between students and police. It illustrates several components of human aggressive behaviour which are similar to those observed in animals, but also some typically human aspects, e. g. the functions of verbalisation as part of aggressive behaviour, some typical forms of submissive behaviour, the role of the uniform as a signal inducing either submission or aggression or an alternation of the two. One aggressive interaction occurred before one of the participants 'realized' what happened. This suggests that at least some components of human aggression are controlled by nervous systems which can function more or less independently from those which control speech and conscious thinking and reflexion.
Growth hormone-releasing hormone receptor (GHRH-R) mRNA expression in human pituitary adenomas: A study by catalyzed reporter deposition-In situ hybridization (CARD-ISH)
Authors: Hidehiro Oka, Long Jing, Bernd W. Scheithauer, Naoko Sanno, Kiyotaka Fujii, Toru Kameya, Timothy B. Plummer, Ricardo V. Lloyd
Journal: Endocrine Pathology (1999)
Book Review Treatment of the Obese Patient (Contemporary Endocrinology.) Edited by Robert F. Kushner and Daniel H. Bessesen. 440 pp., illustrated. Totowa, NJ, Humana Press, 2007. $129. 978-1-58829-735-8 Obesity: Epidemiology, Pathophysiology, and Prevention (CRC Series in Modern Nutrition Science.) Edited by Debasis Bagchi and Harry G. Preuss. 569 pp., illustrated. Boca Raton, FL, CRC Press, 2007. $149.95. 978-0-8493-3802-1
Authors: Margo A. Denke
Journal: New England Journal of Medicine (2007)

This report presents trends in national estimates of mean weight, height, and body mass index (BMI) from the National Health Examination and the National Health and Nutrition Examination Surveys between 1960 and 2002.The tables included in this report present data for adults by sex, race/ethnicity, and age group and for children by sex and year of age.Mean weight and BMI have increased for both sexes, all race/ethnic groups, and all ages.Among adults, mean weight increased more than 24 pounds.Although not as dramatically, mean height has also increased for most ages and for both males and females.
Cognitive incrementalism: The big issue
Authors: Andy Clark
Journal: Behavioral and Brain Sciences (2000)

Neural organization raises, in an especially clear way, a major problem confronting contemporary cognitive science. The problem (the “big issue” of my title) is: What is the relation between the strategies used to solve basic problems of perception and action and those used to solve more abstract or “cognitive” problems? Is there a smooth, incremental route from what Arbib et al. call “instinctual schemas” to higher-level kinds of cognitive prowess? I argue that, despite some suggestive comments, Arbib et al. do not resolve this issue.
Serum ferritin levels in acute hepatocellular damage from paracetamol overdosage.
Authors: E J Eastham, J I Bell, A P Douglas
Journal: BMJ (1976)

y-globulin.When more fully characterised there is hope that these factors mnay be useful as adjuvants to conventional inimunosuppressive regimens and may find regular application in the protocol for the treatment of severe rejection rather than being used as a "last-ditch" measure.
VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain
Authors: Zheng Gang Zhang, Li Zhang, Quan Jiang, Ruilan Zhang, Kenneth Davies, Cecylia Powers, Nicholas van Bruggen, Michael Chopp
Journal: Journal of Clinical Investigation (2000)

VEGF is a secreted mitogen associated with angiogenesis and is also a potent vascular permeability factor. The biological role of VEGF in the ischemic brain remains unknown. This study was undertaken to investigate whether VEGF enhances cerebral microvascular perfusion and increases blood-brain barrier (BBB) leakage in the ischemic brain. Using magnetic resonance imaging (MRI), three-dimensional laser-scanning confocal microscope, and functional neurological tests, we measured the effects of administrating recombinant human VEGF165 (rhVEGF165) on angiogenesis, functional neurological outcome, and BBB leakage in a rat model of focal cerebral embolic ischemia. Late (48 hours) administration of rhVEGF165 to the ischemic rats enhanced angiogenesis in the ischemic penumbra and significantly improved neurological recovery. However, early postischemic (1 hour) administration of rhVEGF165 to ischemic rats significantly increased BBB leakage, hemorrhagic transformation, and ischemic lesions. Administration of rhVEGF165 to ischemic rats did not change BBB leakage and cerebral plasma perfusion in the contralateral hemisphere. Our results indicate that VEGF can markedly enhance angiogenesis in the ischemic brain and reduce neurological deficits during stroke recovery and that inhibition of VEGF at the acute stage of stroke may reduce the BBB permeability and the risk of hemorrhagic transformation after focal cerebral ischemia.
IMAGE CHARACTERISTICS OF CORONARY ARTERIES BY 320-SLICE CT IN SUBJECTS WITH SPASTIC ANGINA PECTORIS CONFIRMED BY ACETYLCHOLINE LOADED TEST ON CONVENTIONAL CORONARY ANGIOGRAPHY
Authors: Masae Uehara, Nobusada Funabashi, fujimoto yoshihide, Hiroyuki Takaoka, Koya Ozawa, Yoshio Kobayashi
Journal: Journal of the American College of Cardiology (2012)
Today, I made an old man cry.
Authors: Kalyan Banda
Journal: Annals of Internal Medicine (2012)

Ad Libitum17 January 2012Today, I made an old man cry.Kalyan Banda, MBBSKalyan Banda, MBBSFrom University of California, San Diego, San Diego, CA 92103-8425.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-156-2-201201170-00005 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Every morning I asked you, the cheerfully greeted,the date, the time, the place and in essence the person you are.Every morning I placed these,as the crystal sum of your being to my circle in white.Every morning I failed to notice, the flinch,the narrow bewildered cloud over your eyes,your wife as she found your searching withered hand,and the crinkle of panic on your forehead.Every morning, I dragged the rigmarole of your mind in viewof its mortality, dancing the dance it does,and left you with a cruel dawning recall of loss.Today … well today,I made an old man cry. Author, Article, and Disclosure InformationAffiliations: From University of California, San Diego, San Diego, CA 92103-8425.Current Author Address: Kalyan Banda, MBBS, Department of Internal Medicine, University of California, San Diego, 402 Dickinson Street, MC 8425, San Diego, CA 92103-8425. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 17 January 2012Volume 156, Issue 2Page: 114KeywordsMortality ePublished: 17 January 2012 Issue Published: 17 January 2012 Copyright & PermissionsCopyright © 2012 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Politics comes before health care in Quebec
Authors: D. Spurgeon
Journal: BMJ (1997)

The Canadian province of Quebec will have to import surgeons from Toronto and France because of its decision last year to move the province's only lung transplant programme to the capital, Quebec City.

There are no suitably qualified surgeons in Quebec, and last year's decision angered doctors and lay people in Montreal. This anger has now turned to ridicule. The Montreal English language newspaper, the Gazette , called …
Principles of Sports Medicine
Authors: Bruno Balke
Journal: JAMA (1985)

The title suggests that this book might be a basic text useful for a practitioner in the general area of sports medicine. The editors intend to enhance the understanding of medical issues in sports by physicians, coaches, trainers, and athletes and their parents. The book contains three parts: "Physiology in Sports" (39 pages), "Recognition and Treatment of Injuries" (322 pages), and "Preventative Sports Medicine" (63 pages). Emphasis is on risks and incidents in athletic training and competition, and, therefore, it is understandable that the orthopedic side of sports medicine takes up most of the text. In the first chapter of Part 1, the physiology of the cardiovascular system is covered adequately, but there is no follow-up chapter on pulmonary function. The neuromuscular system is treated quite thoroughly. The chapters on nutrition and on the nonmedical use of drugs in sports provide useful information for the dialogue between the physician and
Transient restoration of gene rearrangement at multiple T cell receptor loci in gamma-irradiated scid mice.
Authors: F Livák, S C Welsh, C J Guidos, I N Crispe, J S Danska, D G Schatz
Journal: The Journal of Experimental Medicine (1996)

The developmental arrest of thymocytes from scid mice, deficient in variable, (diversity), and joining, or V(D)J recombination, can be overcome by sublethal gamma-irradiation. Since previous studies focused on restoration of rearrangement of the T cell receptor (TCR) beta locus, productive rearrangement of which is selected for, we sought to examine to what extent locus specificity and cellular selection contributed to the observed effects. We report here that irradiation of newborn scid mice induces normal V-D-J rearrangements of the TCR delta locus, which like TCR beta, is also actively rearranged in CD(4-)CD(8-) (double negative) thymocytes. In contrast, no complete V-J alpha rearrangements were detected. Instead, we detected substantial levels of hairpin-terminated coding ends at the 5' end of the J alpha locus, demonstrating that TCR alpha rearrangements manifest the effects of the scid mutation. Irradiation, therefore, transiently compensates for the effects of the scid mutation in a locus-nonspecific manner in thymocytes, resulting in a burst of normal TCR beta and delta rearrangements. Irradiation also allows the development of cells that can initiate but fail to complete V(D)J recombination events at the TCR alpha locus, which is normally inaccessible in scid thymocytes.
Maximum urine concentrating ability in children with Hb SC disease: Effects of hydroxyurea
Authors: Rathi Iyer, Radhakrishna Baliga, Ronald L. Nagel, Carlo Brugnara, Kent Kirchner, Shirley Hogan, Martin H. Steinberg
Journal: American Journal of Hematology (2000)

Studies in adults with Hb SC disease suggested that hydroxyurea reduced hemolysis and increased red cell hydration. Because increased hydration should diminish the polymerization tendency of Hb S we hypothesized that hydroxyurea might repair the urine concentration defect of HbSC disease. Eight Hb SC disease patients, aged 10 to 17 years, were given hydroxyurea daily. Maximal urine concentrating ability following overnight fasting and after subcutaneous arginine vasopressin (dDAVP), blood counts, and cell volumes were observed for 12-15 months. All patients had impaired urine concentrating ability prior to hydroxyurea treatment and failed to increase their ability to concentrate urine following treatment (maximum urine concentration after an overnight fast and dDAVP, 520-530 mOsm). Mean corpuscular volume (MCV) and reticulocyte MCV increased after administration of hydroxyurea, and the reticulocyte count and ratio of red cell hemoglobin to reticulocyte hemoglobin fell but there was little change in PCV. Hb F increased substantially in 2 patients but showed little change in the remaining patients. There was no evidence that hydroxyurea was associated with increased urine concentrating ability in children with Hb SC disease. These results may reflect irreversible renal medullary damage prior to beginning treatment or insufficient intensity or duration of treatment.
Neutrophil superoxide anion–generating capacity, endothelial function and oxidative stress in chronic heart failure: effects of short- and long-term vitamin C therapy
Authors: Gethin R Ellis, Richard A Anderson, Derek Lang, Daniel J Blackman, R.H.Keith Morris, Jayne Morris-Thurgood, Ian F.W McDowell, Simon K Jackson, Malcolm J Lewis, Michael P Frenneaux
Journal: Journal of the American College of Cardiology (2000)
Nontuberculous mycobacterial cutaneous infection confirmed by biochemical tests, polymerase chain reaction-restriction fragment length polymorphism analysis and sequencing of hsp65 gene
Authors: X.J. Li, Q.X. Wu, X.S. Zeng
Journal: British Journal of Dermatology (2003)

Journal Article Nontuberculous mycobacterial cutaneous infection confirmed by biochemical tests, polymerase chain reaction‐restriction fragment length polymorphism analysis and sequencing of hsp65 gene Get access X.J. Li, X.J. Li Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, 14 Jiangwangmao Road, Taipingmen, Nanjing 210042, China Search for other works by this author on: Oxford Academic Google Scholar Q.X. Wu, Q.X. Wu Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, 14 Jiangwangmao Road, Taipingmen, Nanjing 210042, China Dr Qinxue Wu. E‐mail: wuqx2003@hotmail.com Search for other works by this author on: Oxford Academic Google Scholar X.S. Zeng X.S. Zeng Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, 14 Jiangwangmao Road, Taipingmen, Nanjing 210042, China Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 149, Issue 3, 1 September 2003, Pages 642–646, https://doi.org/10.1046/j.1365-2133.2003.05564.x Published: 01 September 2003 Article history Accepted: 14 May 2003 Published: 01 September 2003
BamH I polymorphism in the Chinese: its potential usefulness in prenatal diagnosis of beta thalassaemia.
Authors: V Chan, N K Leung, T K Chan, A Ghosh, Y W Kan, D Todd
Journal: BMJ (1984)

The prevalence of the BamH I site 3' to the beta globin gene in Chinese people was determined in 123 normal subjects, 40 patients with heterozygous beta thalassaemia, and 25 patients with homozygous beta thalassaemia. The site was present in 71.1% and absent in 28.9% of the chromosomes carrying normal beta genes. All 25 patients with beta thalassaemia major had the site. This BamH I polymorphism may be used for prenatal diagnosis in about 29% of the pregnancies at risk.
HEMANGIOMAS OF THE KNEE JOINT
Authors: JOHN T. O'FERRALL
Journal: JAMA (1925)

The occurrence of hemangiomas is rare, judging from the scarcity of references in the current literature and textbooks. Recent clinical experience with this condition occurring in the knee joint, and the fact that it heretofore has not been mentioned in reference to other "internal derangements" of the knee joint, prompt me to call attention to it. It is important as a distinct entity of marked seriousness and also from the standpoint of differential diagnosis. A recent complete and painstaking review of the literature of hemangiomas occurring in all parts of the body with particular reference to those developing in the nervous system, by Stewart and Bettin,<sup>1</sup>will be referred to frequently, and the value of its conclusions acknowledged. Hemangiomas are in no way similar to varicose vessels or aneurysms, but are a neoplastic overgrowth of blood vascular tissue. They are composed of irregular spaces lined with epithelium, but the
Amnesty's Impact Upon Drug Use: A Pre/Post Study
Authors: JOHN F. GREDEN, DONALD W. MORGAN
Journal: American Journal of Psychiatry (1972)

A survey to determine patterns of drug use and attitudes toward treatment was conducted shortly before the establishment of a drug abuse control program in the Army. Eight months after the program was begun, the survey was repeated, using a similar population at the same military installation. Comparison of the surveys revealed no immediate beneficial effects of the program. Reports of previous drug use had increased. The number of those who intended to use nonopiate drugs in the future had increased; willingness to seek treatment remained unchanged and a great deal of skepticism still prevailed.
Developments in Digestive Diseases: Clinical Relevance
Authors: Daniel H. Winship
Journal: JAMA (1978)

A group of high-quality state-of-the-art reviews of rapidly developing topics in medicine is always welcome, and Dr Berk has certainly put together a volume of such articles here. Each of the areas he has selected is in the forefront of gastroenterological advance, and each review is authored by one or more of the respected names in the field. Just a short time ago, the only treatment available for duodenal ulcer disease was therapy that was based on (we thought) rational principles but that had never been shown to be effective. Now there are several agents and programs of therapy that not only hold promise but have actually been demonstrated to have benefit in the treatment of this common, perplexing disease. Not long ago we had no means of visualizing the pancreas, and we could get a look at the biliary tract with great difficulty and sometimes hazard. The update here
Cycle Length Dynamics and Spatial Stability at the Onset of Postinfarction Monomorphic Ventricular Tachycardias Induced in Patients and Canine Preparations
Authors: Alain Vinet, René Cardinal, Pierre LeFranc, François Hélie, Pierre Rocque, Teresa Kus, Pierre Pagé
Journal: Circulation (1996)

The aim of this study was to determine whether cycle length (CL) variations at the onset of monomorphic ventricular tachycardias follow distinctive patterns.We retrospectively analyzed 59 monomorphic ventricular tachycardias induced in 40 patients in whom intraoperative mapping was performed with 63 epicardial and 64 endocardial electrograms recorded simultaneously. Activation times and CL were determined at each electrode site over several beats (36+/-10 beats, mean+/-SD) starting with the first after programmed stimulation. In the majority of the tachycardias, CL variations were accounted for by fitting to an exponential function: CL=CLs+Ae-b/tau, where CLs is the stable CL, b is beat number, tau is the time constant (in beat number), and A is the magnitude of CL relaxation. A decelerating trend (with reference to rate) (negative A) accounted for 21 tachycardias, an accelerating trend in rate (positive A) accounted for 12 tachycardias, and 4 others displayed a double dynamic behavior, with an initial acceleration followed by a decelerating trend in rate. Among the ventricular tachycardias that were not fitted to exponential models, 12 showed a constant trend and 10 others showed irregular CL fluctuations. The monomorphic character of the tachycardias was established by principal-component analysis, which also indicated that CL dynamics associated with the accelerating and decelerating trends may be related to shortening and prolongation of activation times, respectively, occurring in equal proportion at all recording sites. In canine preparations in which reentry circuits could be mapped with high resolution, CL showed an accelerating trend in rate when circus movement of excitation occurred around a transmural scar in muscle generating unipolar electrograms with relatively high -dV/dtmax, and a decelerating trend in rate occurred when functional reentry occurred in muscle generating unipolar electrograms with depressed -dV/dtmax.Beat-to-beat CL variations may occur at the onset of sustained monomorphic ventricular tachycardia as a result of uniform acceleration or deceleration of activation times while the overall activation pattern remains constant. The associated initial trends in the rate of sustained monomorphic ventricular tachycardia follow typical patterns that might provide "signatures" corresponding to reentry substrates with distinctive functional properties.