tbuckley/cabot-search huggingface dataset:
Induction of contact dermatitis in guinea pigs by quaternary ammonium compounds: the mechanism of antigen formation.
Authors: K U Schallreuter, K H Schulz, J M Wood
Journal: Environmental Health Perspectives (1986)

Eight quaternary ammonium compounds were tested for their ability to induce contact dermatitis in guinea pigs by using a modified Freund's complete adjuvant test together with the guinea pig maximization test. Only two quaternary ammonium salts of the eight tested could be designated as strong allergens. These two active substances were shown to be capable of stable association with membrane lipids in forming immunogenic complexes. This surface complexation phenomenon was confirmed by using a spin-labeled quaternary ammonium salt which competed for binding sites at the surface of epidermal cells in vivo. Electron spin resonance was used to demonstrate that stable "ion-pairs" are formed between binding sites and the two allergenic preservatives. Furthermore, information was obtained on the kinetics of immunogenic complex formation as well as on the position and orientation of the quaternary ammonium ion at the cell surface.
LONG-TERM RESULTS OF SUBSTRATE-BASED VENTRICULAR TACHYCARDIA ABLATION IN PATIENTS WITH PREVIOUS MYOCARDIAL INFARCTION. IDENTIFICATION OF ANATOMICAL AND ELECTROPHYSIOLOGICAL SUCCESS PREDICTORS
Authors: Angel Arenal, Gabriel Eidelman, David Calvo, Felipe Atienza, Leonardo Atea, Tomas Datino, Esteban Gonzalez Torrecilla, Angel Miracle, Jesus Hernandez, Cecilia Ceballos, Francisco Fernandez Aviles
Journal: Journal of the American College of Cardiology (2011)
Elevated High-Density Lipoprotein Cholesterol Levels Are Protective Against Plaque Progression
Authors: Stein Harald Johnsen, Ellisiv B. Mathiesen, Einar Fosse, Oddmund Joakimsen, Eva Stensland-Bugge, Inger Njølstad, Egil Arnesen
Journal: Circulation (2005)

There is an inverse relationship between HDL cholesterol and coronary heart disease. Experimental studies have indicated that HDL cholesterol may exert an antiatherogenic effect by inducing regression of atherosclerotic plaques and by turning lipid-rich plaques into more fibrotic lesions. In this prospective, population-based ultrasound study, we investigated how HDL cholesterol relates to carotid plaque progression.The study included 1952 men and women aged 25 to 82 years who had at least 1 plaque present in the right carotid artery at baseline examination (1994). All plaque images were computer processed to yield a measure of plaque area in square millimeters and echogenicity, expressed as the gray-scale median. After 7 years of follow-up, a new ultrasound screening was performed, and the changes in plaque area and echogenicity were assessed. In a multivariable adjusted model, HDL cholesterol, age, systolic blood pressure, and current smoking were independent predictors of plaque growth. For a 1-SD (0.41 mmol/L) lower HDL cholesterol level, mean (SE) plaque area increased by 0.93 mm2 (0.44 mm2; P=0.03). When users of lipid-lowering drugs were excluded from analysis, the HDL estimate was strengthened (beta=1.46 mm2, P=0.002). Although plaque area increased in 70% of cases, and most plaques became more echogenic over the follow-up interval, the plaques that became more echolucent grew more in size than those that became more echogenic (P=0.002).This study shows that a high level of HDL cholesterol reduces plaque growth in subjects with preexisting carotid atherosclerosis. Transformation of the plaque mass into higher echogenicity is associated with reduced growth. Our findings may indicate that HDL cholesterol stabilizes plaques and counteracts their growth by reducing their lipid content and inflammation.
Argon Plasma Coagulation after Piecemeal Polypectomy of Sessile Colorectal Adenomas: Long-Term Follow-Up Study
Authors: J. Regula, E. Wronska, M. Polkowski, A. Nasierowska-Guttmejer, J. Pachlewski, M. Rupinski, E. Butruk
Journal: Endoscopy (2003)

Background and Study Aims: The aim of this study was to evaluate prospectively the long-term outcomes of using argon plasma coagulation (APC) as an adjunct to piecemeal polypectomy of large sessile colorectal adenomas. Patients and Methods: A total of 77 patients with 82 sessile colorectal adenomas (median size 2.9 cm, range 1.5 - 8.0 cm) underwent snare piecemeal polypectomy. Patients in whom polypectomy was complete received no further treatment (polypectomy group; n = 14). When polypectomy was incomplete, additional treatment with APC was started either immediately or 1 - 3 months after the last polypectomy session (polypectomy + APC group; n = 63). Patients were followed (by endoscopy and biopsy) at regular intervals. Results: Histologically proven adenoma eradication was achieved in 100 % of patients (14/14) in the polypectomy group and in 90 % of patients (57/63) in the polypectomy + APC group (two patients died of unrelated causes before adenoma was eradicated, two underwent operation because cancer was detected in the polyp treated, and two underwent operation because of endoscopic treatment failure). The adenoma recurrence rate was 14 % in both the polypectomy and polypectomy + APC groups. All recurrences except one occurred during the first year of follow-up and all were successfully re-treated endoscopically. A total of 69 patients in whom long-term follow-up data are available are free from adenoma at a median follow-up of 37 months (range 12 - 80). No major complications of endoscopic treatment occurred. In seven cases (9 %) the polyp was eventually shown to be malignant; in two of these patients the diagnosis of cancer was delayed as a result of unsuccessful endoscopic treatment. Conclusions: APC used in combination with piecemeal polypectomy of large colorectal adenomas is an effective and safe method of therapy, provided patient selection is careful and follow-up close.
New report evaluates environmental impact of NHS
Authors: Chibuzo Odigwe
Journal: BMJ (2004)

The NHS's “ecological footprint”—an indication in land area of an organisation's consumption ofnatural resources—is about five million hectares, about a fifth of the acreage of the United Kingdom, says a new report.

The report gives details of a study that was begun in 2001 to assess the environmental impact of NHS activities and was launched in London last …
TCT-29 Radial versus femoral access for coronary angiography and intervention in patients with acute coronary syndromes: results of the Zwolle Myocardial Infarction Study Group
Authors: Rik Hermanides, Jan Paul Ottervanger, Jan-Henk Dambrink, Marcel Gosselink, Evelien Kolkman, Vincent Roolvink, Jan Hoorntje, Arnoud van 't Hof
Journal: Journal of the American College of Cardiology (2012)
Principles of Internal Medicine
Authors: John H. Talbott
Journal: JAMA (1962)

The fourth edition of Harrison is deserving of outstanding praise in this section, although it is one of the standard and best known texts in internal medicine. There are more than 100 contributors—an indispensable practice for a system of medicine, comprehensive and contemporary, and yet sufficiently concise to be presented in one volume. The planning and delegation of responsibility for composition has been the assignment of the Editorial Board, who assemble at regular intervals for conference and contemplation. On three occasions in the 17-year history of the Editorial Board, they have met at Jackson Hole, Wyo.; St. Croix, Virgin Islands; and Taormina, Sicily. Seclusion in such delightful areas and removal from the routine harassments of academic life, I am confident, contributed to the excellence of the documented results. There are two principal groups of individuals who have need for medical texts: the medical student and the practicing physician. In internal
The fight for primary care
Authors: Fiona Godlee
Journal: BMJ (2007)

Thirty years ago next year, the Alma Ata Declaration set a new framework for international health. At a meeting convened by WHO in the capital of what is now Kazakhstan, the world's nations agreed that health was far more than the absence of disease, that it was an inalienable right, that urgent action was needed to tackle health inequities between and within countries, and that primary care was the key to achieving health for all. The year 2000 came and went with fireworks but with health still in the hands of the world's wealthy few. As the new deadline of 2015 nears, …
An Outbreak of a Newly Recognized Chronic Diarrhea Syndrome Associated With Raw Milk Consumption
Authors: Michael T. Osterholm, Kristine L. MacDonald, Karen E. White, Joy G. Wells, John S. Spika, Morris E. Potter, Jan C. Forfang, Ronald M. Sorenson, Paul T. Milloy, Paul A. Blake
Journal: JAMA (1986)

A previously undescribed chronic diarrhea syndrome affected 122 residents of Brainerd, Minn, between December 1983 and July 1984. The illness lasted at least one year for 75% of case-patients and was characterized by acute onset, marked urgency, a lack of systemic symptoms, and a failure of response to antimicrobial agents. Clinical and laboratory data indicate that the diarrhea was caused by a secretory mechanism. Consumption of raw milk from a single dairy was associated with illness (odds ratio, 28.3; 95% confidence interval, 9.0 to 89.0). A median incubation period of 15 days was determined for seven case-patients. Possible secondary transmission was noted in one family. Extensive laboratory examination did not identify an etiologic agent. Outbreaks or sporadic cases of a similar illness have occurred in at least seven states; the outbreaks were less extensively investigated and findings were not published, but raw milk consumption was common in the affected persons. This illness appears to represent a previously unrecognized but important clinical entity and public health problem. The etiology and effective therapy for this illness must be determined by further studies of sporadic cases and outbreaks. (<i>JAMA</i>1986;256:484-490)
Pathogenic organisms in the sputum of patients with chronic bronchitis
Authors: O. L. Wade, P. C. Elmes, E. Bartley
Journal: Thorax (1967)

Bacteriological examination of the early morning sputum from 54 patients with chronic bronchitis, half of whom received chemoprophylaxis with oxytetracycline, was made regularly for periods up to four and a half years. Nasal and perineal swabs were taken for periods up to three and a half years. There was no evidence that frequent or dangerous proliferation of drug-resistant organisms occurred in the sputum of patients on prolonged chemoprophylaxis with oxytetracycline nor that a serious increase of the carriage of drug-resistant <i>Staphylococcus pyogenes</i> occurred in the nares or on perineal skin. In patients receiving oxytetracycline there was a significant reduction in the frequency of identification of <i>Streptococcus pneumoniae</i>, but the organism was not eradicated: no significant change in the frequency of identification of <i>Haemophilus influenzae</i> was found. From year to year there was sometimes variation in the frequency of identification of <i>Strep. pneumoniae</i> and <i>Strep. pyogenes</i> in the sputum of these patients.
LABORATORY ABNORMALITIES IN THE DIAGNOSIS AND MANAGEMENT OF LUPUS ERYTHEMATOSUS
Authors: N. R. ROWELL
Journal: British Journal of Dermatology (1971)

Journal Article LABORATORY ABNORMALITIES IN THE DIAGNOSIS AND MANAGEMENT OF LUPUS ERYTHEMATOSUS Get access N. R. ROWELL N. R. ROWELL Department of Dermatology, University of Leeds Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 84, Issue 3, 1 March 1971, Pages 210–216, https://doi.org/10.1111/j.1365-2133.1971.tb14209.x Published: 01 March 1971 Article history Accepted: 13 November 1970 Published: 01 March 1971
Managing Labor — Never Walk Alone
Authors: Robert C. Cefalo, Watson A. Bowes
Journal: New England Journal of Medicine (1998)

In 1833, William P. DeWees wrote that during labor “the patient should be directed to keep as quiet as possible and that the preposterous custom of obliging her to walk the floor with a view to increase the pains when tardy should be peremptorily forbidden.”1 This admonition can be juxtaposed with the one expressed in 1903 by J. Whitridge Williams: “[a woman] should not be compelled to take to her bed unless she feels so inclined.”2 To walk or not to walk has always been the question — and it is still unanswered. In this issue of the Journal, Bloom . . .
Ranitidine: A New H<sub>2</sub>-Receptor Antagonist
Authors: Jan Koch-Weser, Jerome B. Zeldis, Lawrence S. Friedman, Kurt J. Isselbacher
Journal: New England Journal of Medicine (1983)

OVER the past six years the treatment of peptic-ulcer disease has been dramatically altered by the introduction and use of cimetidine. This substituted imidazole compound is an effective H2-receptor antagonist, which acts on the gastric parietal cell to inhibit gastric acid production. Cimetidine is prescribed worldwide, and on the basis of numerous controlled clinical trials, it is considered effective in the healing of both duodenal1 and gastric ulcers.2 Recently, ranitidine, another H2-receptor antagonist, has undergone extensive clinical studies and has been approved by the U.S. Food and Drug Administration for the short-term treatment of duodenal ulcers . . .
A Small Price to Pay
Authors: C. L. Frost
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract B87: Antiangiogenic and antimetastatic activities of cat's whiskers tea (<i>Orthosiphon stamineus</i>) extract against colon cancer cell line
Authors: Fouad Saleih Alsuede, Aman Shah Abdul Majid, Khadeer Ahamed Mohamed B, Z Ismail, M.O Kadir, Amin Malik Shah Abdul Majid
Journal: Cancer Research (2013)

Abstract Orthosiphon stamineus is a popular medicinal herbal tea that is traditionally used for inflammatory joint condition, diabetes and hypertension. In this study we found that the 50% ethanolic extract of O. stamineus strongly suppressed angiogenesis in isolated rat aortic tissues and prevented the formation of chorionic plexus in chick embryo. The extract also inhibited the formation of blood vessels in matrigel plug implanted in mice. A significant inhibition of important stages of HCT-116 colon cancer cells metastasis, invasion, and migration was also observed with significant inhibitory effect of on the growth of the neoplastic cells. However, the extract displayed low cytotoxicity towards human tumor cell lines such as K562, HL-60, Skno-1, MCF-7, HCT-116 and Hep G2, and normal human colonic fibroblast CCD-18Co. HPLC analysis reveals that the extract is abundant with rosmarinic acid, eupatorin, sinensetin, etc. This work highlights usefulness of O. stamineus in treating colon cancer. Note: This abstract was not presented at the conference. Citation Format: Fouad Saleih Alsuede, Aman Shah Abdul Majid, Khadeer Ahamed Mohamed B, Z Ismail, M.O Kadir, Amin Malik Shah Abdul Majid. Antiangiogenic and antimetastatic activities of cat's whiskers tea (Orthosiphon stamineus) extract against colon cancer cell line. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Invasion and Metastasis; Jan 20-23, 2013; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2013;73(3 Suppl):Abstract nr B87.
LONG-TERM CHANGES IN EPICARDIAL ADIPOSE TISSUE AFTER BARIATRIC SURGERY: A CMR STUDY
Authors: María Luaces, Mariana Paiva, Sandra Secades Gonzalez, Catarina Vieira, Jorge Cabezudo Pedrazo, Alejandro García-Muñoz Najar, Manuel Medina Garcia, Alfonso Antequera-Pérez, Leopoldo Pérez de Isla, Victoria Cachofeiro
Journal: Journal of the American College of Cardiology (2013)
The Treatment of Essential Hypertension with Pentolinium Tartrate Combined with Rauwolfia Alkaloids
Authors: C. W. C. Bain, F. Ashton, B. P. Jones
Journal: BMJ (1955)

<h3>Objective</h3> To assess the association between daily moderate-to-vigorous physical activity (MVPA) and dentate gyrus volume (DGv) in pediatric patients with acquired demyelinating syndromes (ADSs) of the CNS. <h3>Methods</h3> Cross-sectional analysis of accelerometry (7 days) and research protocol MRI data from 12 pediatric MS and 18 children with monophasic ADS (monoADS). Total brain and DGv were quantified using standardized methods. The association of daily minutes of MVPA with normalized DGv (nDGv) was assessed using multivariable generalized linear models. <h3>Results</h3> Median (interquartile range) MVPA was lower in MS patients [9.5 (14)] and exhibited less variation than in monoADS patients [24.5 (47)]. nDGv did not differ significantly between groups [mean nDGv (SD) [cm<sup>3</sup>]: MS 0.34 (0.1); monoADS 0.4 (0.1); <i>p</i> = 0.100]. In the monoADS group, every 1-minute increase in MVPA was associated with a 2.4-mm<sup>3</sup> increase in nDGv (<i>p</i> = 0.0017), an association that was independent of age at incident demyelination, time from incident demyelination, sex, and brain white matter T2 lesion volume. No significant association was found between MVPA and nDGv (−2.6 mm<sup>3</sup>/min, <i>p</i> = 0.16) in the MS group. <h3>Conclusions</h3> Higher MVPA associates with greater nDGv in children who have recovered from monophasic demyelination. Larger studies are required to determine whether MVPA can promote regional brain development, or limit tissue damage, in youth with MS.
Allergic Reactions to Insulin
Authors: Phillip Lieberman
Journal: JAMA (1971)

Two of five patients with acute systemic allergic reactions to insulin injection required desensitization. Immunologic studies consisted of direct skin testing with a variety of insulins which included human and synthetic insulins. Passive cutaneous transfer, leukocyte histamine release, and radioimmunodiffusion studies were also performed. Fifty diabetic patients without symptoms of insulin allergy were also selected for skin testing with a variety of insulin preparations. Results indicated that insulin allergy may be directed against the insulin molecule itself or against protein contaminants in the commercially available preparation, and that it can be mediated by IgE. Desensitization resulted in precipitous drops in reaginic antibody titers and cutaneous sensitivity, with the simultaneous induction of tolerance to insulin.
Lenalidomide down-regulates the CD20 antigen and antagonizes direct and antibody-dependent cellular cytotoxicity of rituximab on primary chronic lymphocytic leukemia cells
Authors: Rosa Lapalombella, Bo Yu, Georgia Triantafillou, Qing Liu, Jonathan P. Butchar, Gerard Lozanski, Asha Ramanunni, Lisa L. Smith, William Blum, Leslie Andritsos, Da-Sheng Wang, Amy Lehman, Ching-Shih Chen, Amy J. Johnson, Guido Marcucci, Robert J. Lee, L. James Lee, Susheela Tridandapani, Natarajan Muthusamy, John C. Byrd
Journal: Blood (2008)

Lenalidomide, an immunomodulatory agent that enhances antibody-dependent cellular cytotoxicity (ADCC), is currently being investigated as a therapy for chronic lymphocytic leukemia (CLL). The anti-CD20 antibody rituximab is active in CLL and represents a rational agent to combine with lenalidomide. We therefore examined whether lenalidomide combined with rituximab enhances direct apoptosis and ADCC in CLL cells. In contrast to previous reports using CD20-positive lymphoma cell lines, lenalidomide down-regulated CD20 surface antigen expression in CLL patient cells via enhanced internalization, without influencing transcription. The CD20 surface antigen internalization enhanced delivery of an oligonucleotide incorporated into anti-CD20 immunoliposomes. In addition, CD20 surface antigen down-modulation by lenalidomide in CLL was accompanied by diminished rituximab-mediated apoptosis and ADCC. These observations suggest a need for alternative sequencing strategies to avoid antagonism between lenalidomide and rituximab therapy in CLL. In addition, they suggest that lenalidomide therapy might be useful to enhance targeted delivery of RNAi-based therapies using CD20 immunoliposomes in B-cell malignancies.
Neoantigen of the polymerized ninth component of complement. Characterization of a monoclonal antibody and immunohistochemical localization in renal disease.
Authors: R J Falk, A P Dalmasso, Y Kim, C H Tsai, J I Scheinman, H Gewurz, A F Michael
Journal: Journal of Clinical Investigation (1983)

A monoclonal antibody to a neoantigen of the C9 portion of the membrane attack complex (MAC) of human complement has been developed and characterized. The distribution of this neoantigen was assessed by indirect immunofluorescence microscopy in nephritic and nonnephritic renal diseases. The antibody (Poly C9-MA) reacted on enzyme-linked immunosorbent assay (ELISA) with a determinant in complement-activated serum that was undetectable in normal human serum (NHS). Zymosan particles incubated in NHS had positive immunofluorescent staining with Poly C9-MA; however, binding of Poly C9-MA was not observed with zymosan particles incubated in sera deficient in individual complement components C3, C5, C6, C7, C8, or C9. Reconstitution of C9-deficient sera with purified C9 restored the fluorescence with Poly C9-MA. Poly C9-MA reacted positively by ELISA in a dose-dependent manner with purified MC5b-9 solubilized from membranes of antibody-coated sheep erythrocytes treated with NHS but not with intermediate complement complexes. Poly C9-MA also reacted in a dose-dependent manner on ELISA and in a radioimmunoassay with polymerized C9 (37 degrees C, 64 h) (poly C9) but not with monomeric C9. Increasing amounts of either unlabeled poly C9 or purified MC5b-9 inhibited the 125I-poly C9 RIA in an identical manner. These studies demonstrate that Poly C9-MA recognizes a neoantigen of C9 common to both the MAC and to poly C9. By immunofluorescence, Poly C9-MA reacted minimally with normal kidney tissue in juxtaglomerular loci, the mesangial stalk, and vessel walls. Poly C9-MA stained kidney tissue from patients with glomerulonephritis in a pattern similar to that seen with polyclonal anti-human C3. In tissue from patients with nonnephritic renal disease--diabetes, hypertension, and obstructive uropathy--Poly C9-MA was strongly reactive in the mesangial stalk and juxtaglomerular regions, tubular basement membranes, and vascular walls. Poly C9-MA binding was especially prominent in areas of advanced tissue injury. Poly C9-MA frequently stained loci where C3 was either minimally present or absent. These studies provide strong evidence for complement activation not only in nephritic but also in nonnephritic renal diseases.
The Epidemic Malarial Fever of Assam, or Kala-Azar, Successfully Eradicated from Tea Garden Lines
Authors: L. Rogers
Journal: BMJ (1898)

My experience leads me to differ from all these writers in regard to ipecacuanha being useless.In tlhe course of my long service in various parts of the East, Ceylon among tlhe rest, I have found it most valuable in cases of acute tropical dysenltery.