tbuckley/cabot-search huggingface dataset:
Leukemia and Non-Hodgkin'letters Lymphoma Among Embalmers and Funeral Directors
Authors: ATHENA LINOS, AARON BLAIR, KENNETH P. CANTOR, LEON BURMEISTER, STEPHANIE VANLIER, ROBERT W. GIBSON, LEONARD SCHUMAN, GEORGE EVERETT
Journal: JNCI Journal of the National Cancer Institute (1990)

Journal Article Leukemia and Non-Hodgkin'letters Lymphoma Among Embalmers and Funeral Directors Get access ATHENA LINOS, ATHENA LINOS Search for other works by this author on: Oxford Academic PubMed Google Scholar AARON BLAIR, AARON BLAIR Search for other works by this author on: Oxford Academic PubMed Google Scholar KENNETH P. CANTOR, KENNETH P. CANTOR Search for other works by this author on: Oxford Academic PubMed Google Scholar LEON BURMEISTER, LEON BURMEISTER Search for other works by this author on: Oxford Academic PubMed Google Scholar STEPHANIE VANLIER, STEPHANIE VANLIER Search for other works by this author on: Oxford Academic PubMed Google Scholar ROBERT W. GIBSON, ROBERT W. GIBSON Search for other works by this author on: Oxford Academic PubMed Google Scholar LEONARD SCHUMAN, LEONARD SCHUMAN Search for other works by this author on: Oxford Academic PubMed Google Scholar GEORGE EVERETT GEORGE EVERETT Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 82, Issue 1, 3 January 1990, Page 66, https://doi.org/10.1093/jnci/82.1.66 Published: 03 January 1990
Extrapancreatic Autoimmunity in Patients With Latent Autoimmune Diabetes of Adults
Authors: Pedro Weslley Souza Rosario, Janice Sepulveda Reis, Michelle Aparecida Borges, Ricardo Amim, Maria Regina Calsolari, Saulo Cavalcanti Silva, Saulo Purisch
Journal: Diabetes Care (2005)

Type 1 diabetes often occurs in association with other autoimmune diseases (thyroid disease [1–3], Addison’s disease [2], celiac disease [1,3], autoimmune gastropathy [4], and others), with autoimmune thyroiditis beingthe most common (1–3). To determine whether these autoimmune diseases are also more frequent in patients with latent autoimmune diabetes of adults (LADA), we compared the prevalence of anti–21 α-hydroxylase (21OHAb), anti–thyroid peroxidase (TPOAb), anti–parietal gastric cell antibodies, and rheumatoid factor in a group of patients with LADA versus patients with type 2 diabetes.

Fifty-four patients with LADA (>35 years of age at diagnosis who did not require insulin for …
Moderate elevation of intracellular creatine by targeting the creatine transporter protects mice from acute myocardial infarction
Authors: Craig A. Lygate, Steffen Bohl, Michiel ten Hove, Kiterie M.E. Faller, Philip J. Ostrowski, Sevasti Zervou, Debra J. Medway, Dunja Aksentijevic, Liam Sebag-Montefiore, Julie Wallis, Kieran Clarke, Hugh Watkins, Jürgen E. Schneider, Stefan Neubauer
Journal: Cardiovascular Research (2012)

Increasing energy storage capacity by elevating creatine and phosphocreatine (PCr) levels to increase ATP availability is an attractive concept for protecting against ischaemia and heart failure. However, testing this hypothesis has not been possible since oral creatine supplementation is ineffectual at elevating myocardial creatine levels. We therefore used mice overexpressing creatine transporter in the heart (CrT-OE) to test for the first time whether elevated creatine is beneficial in clinically relevant disease models of heart failure and ischaemia/reperfusion (I/R) injury.CrT-OE mice were selected for left ventricular (LV) creatine 20-100% above wild-type values and subjected to acute and chronic coronary artery ligation. Increasing myocardial creatine up to 100% was not detrimental even in ageing CrT-OE. In chronic heart failure, creatine elevation was neither beneficial nor detrimental, with no effect on survival, LV remodelling or dysfunction. However, CrT-OE hearts were protected against I/R injury in vivo in a dose-dependent manner (average 27% less myocardial necrosis) and exhibited greatly improved functional recovery following ex vivo I/R (59% of baseline vs. 29%). Mechanisms contributing to ischaemic protection in CrT-OE hearts include elevated PCr and glycogen levels and improved energy reserve. Furthermore, creatine loading in HL-1 cells did not alter antioxidant defences, but delayed mitochondrial permeability transition pore opening in response to oxidative stress, suggesting an additional mechanism to prevent reperfusion injury.Elevation of myocardial creatine by 20-100% reduced myocardial stunning and I/R injury via pleiotropic mechanisms, suggesting CrT activation as a novel, potentially translatable target for cardiac protection from ischaemia.
Volvulus of the Cecum and Right Colon
Authors: Pamela H. Haskin
Journal: JAMA (1981)

VOLVULUS of the cecum and right side of the colon causes up to 10% of all cases of intestinal obstruction in adults. As reported in recent series, it is only slightly less common than sigmoid volvulus.<sup>2,3</sup>It is more prevalent after age 50 years, although it can occur at any age. No clear-cut gender predisposition exists.<sup>4</sup>Gangrenous change in the bowel wall occurs in two thirds of late-diagnosed cases, with an associated mortality of more than 40%.<sup>1,5</sup> <h3>Pathophysiology</h3> Volvulus of the cecum and right colon occurs when a segment of bowel and mesentery twists on itself, causing obstruction of the bowel lumen and, at times, occlusion of the mesenteric vessels. The term "cecal volvulus" to describe this condition is a misnomer, since the volvulus will usually involve also the right colon as well as the cecum.<sup>5</sup>Two conditions must be met for this entity to occur:
Cirrhosis in a Boy Aged Eleven Years: Jaundice of Nearly Three Years' Duration
Authors: A. W. Fox
Journal: BMJ (1878)

thie system atrg*i?How can you kaww ho' the hanges are toWe treated, how)mosbdproducts are to .beremovd, how zinured organs are to be repaired, how damage-tthe-fissues oloss of life is to be prevented, unless you know, and, kow thoroughly, *bat the noxmal processes
Localization of the ring-infected erythrocyte surface antigen (RESA) of Plasmodium falciparum in merozoites and ring-infected erythrocytes.
Authors: G V Brown, J G Culvenor, P E Crewther, A E Bianco, R L Coppel, R B Saint, H D Stahl, D J Kemp, R F Anders
Journal: The Journal of Experimental Medicine (1985)

Immunoelectron microscopy with protein A gold has been used to determine the subcellular location of the ring-infected erythrocyte surface antigen (RESA) of Plasmodium falciparum. RESA was associated with dense vesicles presumed to be micronemes within merozoites. RESA was not detected on the surface of merozoites but was located at the membrane of erythrocytes infected with ring-stage parasites. RESA within merozoites was largely soluble in the nonionic detergent Triton X-100, but was insoluble in this detergent when associated with the erythrocyte membrane.
Ventricular Preexcitation in Children and Young Adults
Authors: Cristina Basso, Domenico Corrado, Lino Rossi, Gaetano Thiene
Journal: Circulation (2001)

Background —Sudden death (SD) in ventricular preexcitation (VP) syndrome is believed to be the result of atrial fibrillation with rapid ventricular response over the accessory pathway. Previous reports are anecdotal and often lack autopsy validation. Methods and Results —Prevalence and clinicopathological features of VP were investigated in a series of 273 SDs in children and young adults (aged ≤35 years). Site of accessory atrioventricular (AV) connection was predicted by 12-lead ECG. Right and left AV ring together with the sinoatrial and AV septal junction were studied in serial histological sections. Ten patients (3.6%; male, mean age 24±7 years) had VP: 8 had Wolff-Parkinson-White (WPW) and 2 had Lown-Ganong-Levine (LGL) syndrome. Six patients had previous symptoms, and SD occurred at rest in all but 1. Pathological substrates of LGL consisted of AV-node hypoplasia and right-sided atrio-Hisian tract, respectively. In the 8 WPW patients, 10 total accessory AV pathways consisting of ordinary myocardium were found (7 left lateral, 2 right posterolateral, and 1 septal). These pathways were close to the endocardium (mean distance, 750±530 μm) and 310±190 μm thick. In 4 WPW patients (50%), isolated acute atrial myocarditis was found, which was polymorphous in 1 and lymphocytic in 3. Conclusions —VP accounted for 3.6% of SD in young people and was not preceded by warning symptoms in 40%. A left accessory pathway was the most frequent substrate, and its subendocardial location supports the feasibility of catheter ablation. Isolated atrial myocarditis may act as a trigger of paroxysmal atrial fibrillation that leads to SD.
Laboratory Tests for Pituitary Gonadotropins
Authors: Robert C. Northcutt
Journal: JAMA (1969)

The human pituitary gland elaborates two gonadotropins, follicle-stimulating hormone (FSH) and luteinizing hormone (LH). We shall present the currently employed laboratory methods of measuring these hormones and discuss those biological and physicochemical characteristics necessary to the understanding of the assay systems used. Certain aspects of the clinical application of these assay procedures which will prove useful to the practicing physician are included as well as normal values which have been established in various laboratories (Table). <h3>The Hormones</h3> Human pituitary FSH and LH are two distant glycoproteins synthesized in the anterior pituitary gland and released into the blood stream upon the direction of specific releasing hormones from the hypothalamus. These releasing hormones are produced by certain nuclei in the hypothalamus and reach the anterior pituitary by way of a system of portal vessels arising in these nuclei. These hypothalamic centers are the final terminals through which the central nervous system and
Identification and characterization of 2 types of erythroid progenitors that express GATA-1 at distinct levels
Authors: Norio Suzuki, Naruyoshi Suwabe, Osamu Ohneda, Naoshi Obara, Shigehiko Imagawa, Xiaoqing Pan, Hozumi Motohashi, Masayuki Yamamoto
Journal: Blood (2003)
The Influence of Renal Threshold on the Interpretation of Urine Tests for Glucose in Diabetic Patients
Authors: S Walford, M McB Page, S P Allison
Journal: Diabetes Care (1980)

A knowledge of the renal threshold for glucose is important in the interpretation of urine tests in diabetes. We describe a simple method for determining renal threshold from blood and urine tests performed by the patients themselves. In a group of 65 insulin-dependent diabetic patients there was a wide variation in renal threshold, with a mean of 130 mg/dl (range 54–180 mg/dl). Threshold tended to rise with age, and it is suggested that the higher the renal threshold, the higher is the mean blood glucose achieved by the patient (r = 0.50, P = &amp;lt; 0.001). The change in blood glucose required to convert urine tests from 0% to 2% is very variable and ranged from 36 to 288 mg/dl (mean 110 mg/dl). The simple method that we describe may improve understanding of the significance of urine test results without the necessity for hospital admission.
THE CONTROL OF SCARLET FEVER BY ROUTINE CULTURE
Authors: Charles E. Smith
Journal: JAMA (1918)

<h3>To the Editor:</h3> —During my service in the contagious wards at the City and County Hospital, St. Paul, in the winter of 1916-1917, I attempted routine control of the scarlet fever cases by cultures from the nose and throat. A method similar to that in common use for the control of diphtheria was employed, except that the streptococcus was considered instead of the Klebs-Loeffler bacillus. So far as I knew at the time, this had never been attempted as a routine. The attempt at control was made with the consent of the local bureau of health. Routine cultures on admission to the scarlet fever wards had long been an established procedure on account of the frequency with which Klebs-Loeffler bacilli are found in the throats of scarlatinal patients. This varies from 5 to 30 per cent., according to the observer, and was about 10 per cent. in our cases. The
Domestic Violence: Every Community's Problem
Authors: Erin Tracy
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Alltrans-retinoic acid decreases early mortality in patients with promyelocytic leukemia and can be given entirely on an outpatient basis
Authors: Guillermo J. Ruiz-Arg�elles, Eduardo Lobato-Mendiz�bal, Jos� Luis Delgado-Lamas, David G�mez-Almaguer
Journal: American Journal of Hematology (1999)

The results of the treatment of 43 patients with acute promyelocytic leukemia (PML) are reported: 27 were treated initially with all-trans-retinoic acid (ATRA), whereas 16 were treated with conventional chemotherapy. All patients received myelosuppressive chemotherapy after the initial treatment. Respectively, the complete remission rate was 92% and 37% (P < 0.01), the 5-day mortality rate was 0% and 44% (P < 0.001), and the 28-day mortality rate was 4% and 44% (P < 0.001). The median disease-free survival was 12 and 1 months (P < 0.01), whereas the 12-month disease-free survival was 50% and 13% (P < 0.01) and the 36-month disease-free survival was 41% and 9% (P < 0.01). Thirteen of the patients treated with ATRA were given the treatment fully as outpatients. ATRA given as initial therapy decreased significantly early mortality in promyelocytic leukemia patients; because some promyelocytic leukemia patients given ATRA as initial therapy can be treated as outpatients, the costs of this treatment modality may be diminished. Am. J. Hematol. 62:139–143, 1999. © 1999 Wiley-Liss, Inc.
Antibiotic treatment of pelvic inflammatory disease. Trends among private physicians in the United States, 1966 through 1983
Authors: D. A. Grimes
Journal: JAMA (1986)

Although pelvic inflammatory disease is the most common serious infection among young women of reproductive age in the United States, no nationwide data are available on the patterns of antibiotic treatment of this disease. To examine these patterns we analyzed over 25 million antibiotic prescriptions for treatment of pelvic inflammatory disease from 1966 through 1983, using the National Disease and Therapeutic Index. Most patients received a single antibiotic on an outpatient basis. Overall, use of natural penicillins declined markedly, and use of aminopenicillins more than doubled. Cephalosporins emerged as the most frequently prescribed antibiotic for hospitalized patients. Nationwide surveillance of treatment patterns may help to identify areas needing improvement through continuing education.
Cobalamin inactivation decreases purine and methionine synthesis in cultured lymphoblasts.
Authors: G R Boss
Journal: Journal of Clinical Investigation (1985)

The megaloblastic anemia of cobalamin deficiency appears secondary to decreased methionine synthetase activity. Decreased activity of this enzyme should cause 5-methyltetrahydrofolate to accumulate intracellularly, and consequently, decrease purine and DNA synthesis; this is the basis of the "methylfolate trap" hypothesis of cobalamin deficiency. However, only some of the clinical and biochemical manifestations of cobalamin deficiency can be explained by the methylfolate trap. We investigated cobalamin deficiency by treating cultured human lymphoblasts with N2O since N2O inhibits methionine synthetase activity by inactivating cobalamin. We found that 4 h of N2O exposure reduced rates of methionine synthesis by 89%. Rates of purine synthesis were not significantly reduced by N2O when folate and methionine were present at 100 microM in the medium; however, at the physiologic methionine concentration of 10 microM, N2O decreased rates of purine synthesis by 33 and 57% in the presence of 100 microM folate and in the absence of folate, respectively. The dependency of rates of purine synthesis on methionine availability would be expected in cells with restricted methionine synthetic capacity because methionine is the immediate precursor of S-adenosylmethionine, a potent inhibitor of 5-methyltetrahydrofolate synthesis; methionine serves as a source of formate for purine synthesis; and rates of purine synthesis are dependent on the intracellular availability of essential amino acids. We conclude that cobalamin inactivation decreases purine synthesis by both methylfolate trapping and reduction of intracellular methionine synthesis.
Alternative Approaches to Public Health Surveillance of IDDM
Authors: Jeffrey M Newman, William H Herman, Frank Vinicor
Journal: Diabetes Care (1993)

OBJECTIVE To assess the appropriateness of national surveillance of IDDM. RESEARCH DESIGN AND METHODS We reviewed the structure and function of national disease surveillance, the diverse goals of IDDM surveillance, and prior experience with IDDM as a reportable disease. RESULTS Surveillance is the systematic and ongoing collection, analysis, interpretation,and dissemination of data linked to public health action. The potential goals of surveillance of IDDM are to understand the etiology and trends in incidence of IDDM, to measure the burden of IDDM and its complications, and to assess mortality. Problems associated with surveillance of IDDM include underreporting, delayed reporting, and lack of funding. CONCLUSIONS To make IDDM a nationally reportable disease is neither warranted nor feasible at this time. Although surveillance is needed to understand diabetes better and for diabetes control, proposed initiatives, such as major expansions of IDDM reporting, should be developed to address specific questions, problems, and needs— stillrecognizing real-world issues of competing priorities and limited resources.
Health economic assessment of ferric carboxymaltose in patients with iron deficiency and chronic heart failure based on the FAIR‐HF trial: an analysis for the UK
Authors: Florian S. Gutzwiller, Matthias Schwenkglenks, Patricia R. Blank, Peter G. Braunhofer, Claudio Mori, Thomas D. Szucs, Piotr Ponikowski, Stefan D. Anker
Journal: European Journal of Heart Failure (2012)

The purpose of this study was to evaluate the cost-effectiveness of iron repletion using intravenous (i.v.) ferric carboxymaltose (FCM) in chronic heart failure (CHF) patients with iron deficiency with or without anaemia. Cost-effectiveness was studied from the perspective of the National Health Service in the UK.
Orally Given Combinations of Drugs in Diabetes Mellitus Therapy
Authors: Samuel B. Beaser
Journal: JAMA (1960)

A total of 25 ambulatory diabetic patients were treated with a combination of phenformin (DBI) and a sulfonylurea drug (either tolbutamide or chlorpropamide). These patients had failed to respond fully to treatment with a sulfonylurea drug alone. The therapy was successful in reducing blood sugar to satisfactory levels in 19 patients, but 3 discontinued the treatment because of gastrointestinal intolerance. The therapy was unsuccessful in six patients, owing to the severity of the diabetes. The use of a combination of drugs increases the percentage of diabetic patients for whom oral therapy is applicable and decreases the incidence of side effects.
Functional Heterogeneity of Genetically Defined Subclones in Acute Myeloid Leukemia
Authors: Jeffery M. Klco, David H. Spencer, Christopher A. Miller, Malachi Griffith, Tamara L. Lamprecht, Michelle O’Laughlin, Catrina Fronick, Vincent Magrini, Ryan T. Demeter, Robert S. Fulton, William C. Eades, Daniel C. Link, Timothy A. Graubert, Matthew J. Walter, Elaine R. Mardis, John F. Dipersio, Richard K. Wilson, Timothy J. Ley
Journal: Cancer Cell (2014)
Effect of Verapamil on Long-Term Tachycardia-Induced Atrial Electrical Remodeling
Authors: Shih-Huang Lee, Wen-Chung Yu, Jun-Jack Cheng, Chi-Ren Hung, Yu-An Ding, Mau-Song Chang, Shih-Ann Chen
Journal: Circulation (2000)

Background —The effect of verapamil on long-term tachycardia-induced atrial electrical remodeling has not been reported. Methods and Results —Forty-eight dogs were randomly divided into verapamil and control groups. The dogs in the verapamil group received verapamil 120 mg every day, those in the control group did not receive verapamil. Atrial effective refractory period (AERP), inducibility of atrial fibrillation (AF), and duration of AF were assessed before and after complete atrioventricular junction ablation with 1-day, 1-week, or 6-week rapid atrial pacing (780 bpm). AERP shortening, AERP dispersion, AERP maladaptation, and inducibility of AF after 1-day pacing was significantly attenuated by verapamil. However, verapamil did not have any significant effect on these parameters in the dogs with 1-week or 6-week pacing. Verapamil did not have any significant effect on the conduction velocity in the dogs with 1-day, 1-week, or 6-week pacing. Before rapid atrial pacing, verapamil significantly prolonged the duration of AF. In the dogs with 1-day pacing, the duration of AF measured immediately after termination of pacing was similar between the control and verapamil groups. However, in the dogs with 1-week or 6-week pacing, the duration of AF after pacing was significantly longer in the verapamil group. Conclusions —Verapamil cannot prevent long-term (1 and 6 weeks, respectively) tachycardia-induced changes of atrial electrophysiological properties. Furthermore, verapamil increases the duration of AF in the dogs either before or after long-term rapid atrial pacing.
Serum amyloid P attenuates M2 macrophage activation and protects against fungal spore–induced allergic airway disease
Authors: Ana Paula Moreira, Karen A. Cavassani, Rikki Hullinger, Rogério S. Rosada, Daniel J. Fong, Lynne Murray, Dave P. Hesson, Cory M. Hogaboam
Journal: Journal of Allergy and Clinical Immunology (2010)
Serial liver biopsies in psoriatic patients receiving long-term etretinate
Authors: H.H. ROENIGK, C. GIBSTINE, S. GLAZER, M. SPARBERG, H. YOKOO
Journal: British Journal of Dermatology (1985)

Twenty psoriatic patients treated with etretinate have been followed in a prospective study of liver biopsies. Twelve patients were followed up for 3 years, with four liver biopsies each. No significant damage to the liver was found during etretinate therapy. Etretinate may be stored in the fatty tissues of the liver or other body areas for prolonged periods.