tbuckley/cabot-search huggingface dataset:
Book Review Comment
Authors: HARRY T. ZANKEL
Journal: Annals of Internal Medicine (1973)

Letters, Comments, and Corrections1 February 1973Book Review CommentHARRY T. ZANKEL, M.D.HARRY T. ZANKEL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-2-315_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: My attention has been called to Lester S. Dewis's review of my book Stroke Rehabilitation in the June issue (Ann Intern Med 76:1056, 1972).I write about his last paragraph in which he indicates that the usefulness of my text may be limited because I describe the comprehensive Veterans Administration stroke rehabilitation program that I was in charge of for many years, a program that would have limited value to physicians in private practice. May I make two points in reply?The physician should know what can be done with stroke patients where there is an adequate stroke... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited by4-N-substituted piperidines (review) 1 February 1973Volume 78, Issue 2Page: 315-315KeywordsStrokeStroke rehabilitation ePublished: 1 December 2008 Issue Published: 1 February 1973 PDF downloadLoading ...
FOREIGN BODY IN THE NOSE
Authors: Emanuel Krimsky
Journal: JAMA (1952)

To the Editor:—  The report on Angioneurotic Edema Due to Foreign Body Long Present in the Nose ( J. A. M. A.  147 :1234 [Nov. 24] 1951) interested me because it raises controversial questions, which may be summarized as follows:   As to the etiology of the angioneurotic edema, if it is true that a peanut imbedded in the nose could lead to angioneurotic edema of the eyelids, then how is one to explain the strongly fetid local area in the nose as an allergic focus? More likely, one would think of a localized infection rather than an allergy. No mention is made of skin tests made with peanut extract to induce an urticarial skin reaction to prove an allergic involvement of the eyelids, legs, lips, forehead, and wrist.   As to the nature of the angioneurotic edema, no mention is made as to whether the eyelid edema was greater on
Revenge: Behavioral and emotional consequences
Authors: Vladimir J. Konečni
Journal: Behavioral and Brain Sciences (2012)

This commentary discusses dozens of ecologically powerful social-psychological experiments from the1960s and 1970s, which are highly relevant especially for predicting the consequences of revenge. McCullough et al. omitted this work – perhaps because of its misclassification as “catharsis” research. The findings are readily accommodated by Konecˇ ni’s anger-aggression bidirectional-causation (AABC) model and can be usefully incorporated in an adaptationist view of revenge.
Methoxyflurane as an obstetric analgesic: a comparison with trichloroethylene.
Authors: V. Major, M. Rosen, W. W. Mushin
Journal: BMJ (1966)

Log^n, R. F. L., and Eimerl, T. S. (1965). Millbank mem. Fd Quart., 43, No. 2, Pt. 2, pp. 302-310. Logan, W. P. D., and Cushion, A. A. (1958). G.R.O. Stud, on Med. and Pop. Subj. No. 14, vol. 1, Morbidity Statistics from General Practice. H.M.S.O., London. Ministry of Health (1965). Annual Report for 1964. H.M.S.O., London. Peterson, O. L., Andrews, L. T., Spain, R. F., and Greenberg, B. G (1956). J. med. Educ, 31, No. 12, Pi. 1, pp. 1-165. Querido, A. (1963). The Efficiency of Medical Cjve. Stenfert-Kroese, Leiden. van der Wielen, V. (1960). M.D. Thesis :  The General Practitioner and the Effectiveness of his Share in the Care of Health. Leiden.
THE CULTIVATION OF THE SURRA TRYPANOSOME OF THE PHILIPPINES.
Authors: FREDERICK G. NOVY
Journal: JAMA (1904)

Although the<i>Trypanosoma evansi</i>, the cause of surra, was discovered by Evans in India as early as 1880, and the disease itself has been studied exhaustively by Lingard (1893-1896), relatively but little attention has been given to the parasite itself. Koch, while in German East Africa in 1898, described the disease prevailing in that region as surra, because he was of the belief that surra and nagana or the tsetsefly disease were identical. Bruce himself, in his work on the latter disease in 1894, inclined to the view of a possible identity of the trypanosome studied by him with that of Evans. Various other workers have held similar opinions, and even as late as last year Musgrave and Clegg<sup>1</sup>conclude that surra, nagana, mal de caderas, and probably dourine, are the same disease and that all are caused by<i>Tr. evansi</i>. The immunity experiments of Laveran and Mesnil<sup>2</sup>and those
Thyroid Function in the Acquired Immunodeficiency Syndrome (AIDS)
Authors: Kanji Sato, Minoru Ozawa, Hiroshi Demura, Toru Fujii
Journal: Annals of Internal Medicine (1989)

Letters and Corrections15 November 1989Thyroid Function in the Acquired Immunodeficiency Syndrome (AIDS)Kanji Sato, MD, Minoru Ozawa, MD, Hiroshi Demura, MD, Toru Fujii, MDKanji Sato, MDSearch for more papers by this author, Minoru Ozawa, MDSearch for more papers by this author, Hiroshi Demura, MDSearch for more papers by this author, Toru Fujii, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-111-10-857 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:In a recent issue, LoPresti and colleagues (1) reported that serum triiodothyronine (T3) is normal and reverse T3 (rT3) is decreased in emaciated patients with AIDS. This finding is highly unexpected because the T4 levels of such patients are normal or supranormal due to elevated serum thyroxine-binding globulin. Such an inappropriately increased T3/T4 and decreased rT3/T4 ratio contrasts sharply with those usually seen in patients with non-thyroidal illnesses: In these patients, the serum T3 concentration is decreased and rT3 is reciprocally increased (2). This low-T3, high-rT3 state is caused by the adaptation of iodothyronine-5′-deiodinating enzymes for energy-saving...References1. LoPresti J, Fried J, Spencer C, and Nicoloff J. Unique alterations of thyroid hormone indices in the acquired immunodeficiency syndrome (AIDS). Ann Intern Med. 1989;110:970-5. LinkGoogle Scholar2. Chopra I, Hershman J, Pardridge W, and Nicoloff J. Thyroid function in non-thyroidal illnessess. Ann Intern Med. 1983;98:946-57. LinkGoogle Scholar3. Ozawa M, Sato K, Han D, Kawakami M, Tsushima T, and Shizume K. Effect of tumor necrosis factor-alpha/cachectin on thyroid hormone metabolism in mice. Endocrinology. 1988;123:1461-7. CrossrefMedlineGoogle Scholar4. Fujii T, Sato K, and Ozawa M. Effect of interleukin-1 (IL-I) on thyroid hormone metabolism in mice: stimulation by IL-I of iodothyronine 5′-deiodinating activity (type I) in the liver. Endocrinology. 1989;124:167-74. CrossrefMedlineGoogle Scholar5. Lahdevirta J, Maury G, Teppo A, and Repo H. Elevated levels of circulating cachectin/tumor necrosis factor in patients with acquired immunodeficiency syndrome. Am J Med. 1988;85:289-91. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Kanji Sato, MD; Minoru Ozawa, MD; Hiroshi Demura, MD; Toru Fujii, MD PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThyroid Function in Children with Perinatal Human Immunodeficiency Virus Type 1 InfectionEndocrine Dysfunction in Children with HIV-1 InfectionHIV Wasting Syndrome: Treatment Update 15 November 1989Volume 111, Issue 10Page: 857-858KeywordsAIDSAttentionEnzymesGlobulinsThyroidTriiodothyronine ePublished: 1 December 2008 Issue Published: 15 November 1989 PDF downloadLoading ...
Regulatory T Cells and Immune Tolerance to Coagulation Factor IX in the Context of Intramuscular AAV1 Gene Transfer
Authors: Meagan Kelly, Arpita S Bharadwaj, Frank Tacke, Hengjun Chao
Journal: Molecular Therapy (2009)

Regulatory T cells play a major role in induction and maintenance of immune tolerance and immunological homeostasis. A variety of strategies have been attempted to induce regulatory T cells for control of unwanted, adverse immunity in autoimmune diseases, transplantation as well as gene transfer. We recently reported efficient induction of immune tolerance to coagulation factor IX (FIX) following intramuscular AAV1 gene transfer. In the current study, we performed a systematic and comprehensive examination of the role and function of regulatory T cells in induction and maintenance of FIX tolerance in the context of intramuscular AAV1 gene transfer. We observed no significant upregulation of regulatory T cells in the FIX-tolerant mice. In addition, adoptive transfer of splenocytes from FIX-tolerant mice did not suppress anti-hFIX immunity in recipient mice. Both in vitro and in vivo depletion of regulatory T cells failed to reverse FIX tolerance. These observations revealed that regulatory T cells do not play a significant role in the maintenance/protection of the established FIX tolerance. Our results provide critical insight into the role and function of regulatory T cells in induction and maintenance/protection of immune tolerance in gene transfer, complementing the current paradigm of immune tolerance mechanism. Regulatory T cells play a major role in induction and maintenance of immune tolerance and immunological homeostasis. A variety of strategies have been attempted to induce regulatory T cells for control of unwanted, adverse immunity in autoimmune diseases, transplantation as well as gene transfer. We recently reported efficient induction of immune tolerance to coagulation factor IX (FIX) following intramuscular AAV1 gene transfer. In the current study, we performed a systematic and comprehensive examination of the role and function of regulatory T cells in induction and maintenance of FIX tolerance in the context of intramuscular AAV1 gene transfer. We observed no significant upregulation of regulatory T cells in the FIX-tolerant mice. In addition, adoptive transfer of splenocytes from FIX-tolerant mice did not suppress anti-hFIX immunity in recipient mice. Both in vitro and in vivo depletion of regulatory T cells failed to reverse FIX tolerance. These observations revealed that regulatory T cells do not play a significant role in the maintenance/protection of the established FIX tolerance. Our results provide critical insight into the role and function of regulatory T cells in induction and maintenance/protection of immune tolerance in gene transfer, complementing the current paradigm of immune tolerance mechanism.
Rapid generation of maturationally synchronized human dendritic cells: contribution to the clinical efficacy of extracorporeal photochemotherapy
Authors: Carole Berger, Kristin Hoffmann, Juan G. Vasquez, Shrikant Mane, Julia Lewis, Renata Filler, Aiping Lin, Hongyu Zhao, Tyler Durazzo, Abigail Baird, William Lin, Francine Foss, Inger Christensen, Michael Girardi, Robert Tigelaar, Richard Edelson
Journal: Blood (2010)
Direct quantification of apparent binding indices from quinidine-induced in vivo conduction delay in canine myocardium.
Authors: F N Haugland, S B Johnson, D L Packer
Journal: Journal of Clinical Investigation (1994)

To characterize quantitatively the quinidine (QUIN)-induced conduction delay (CD) in vivo, canine ventricular activation times were examined with an epicardial mapping technique. A high-resolution index of normalized (N) QUIN CD, derived from all 56 recording sites, was used to quantify QUIN effect. Repetitive stimulation elicited monoexponential increases in CD(N), the rates of which were a linear function of interpulse recovery interval, tr. Steady-state CD(N) was also linearly related to an exponential function of tr and drug uptake rates. The frequency-dependent properties of QUIN in 14 dogs were characterized by apparent binding and unbinding rates of ka = 7.1 +/- 3.5 x 10(6) M-1 s-1, la = 81 +/- 51 s-1 for activated, and kr = 12.6 +/- 11.3 x 10(3) M-1 s-1, lr = 0.51 +/- 0.26 s-1 for resting states. ka and la were similar to values previously derived in canine Purkinje fibers. Drug unbinding at resting potentials was faster in vivo than previously observed in vitro. The time constant of recovery from QUIN block extracted from the interpulse recovery rate was also identical to that determined from post-mature stimulus diastolic scanning. As predicted by the two-state model, similar binding rates were also derived from declining CD(N) elicited by step decreases in heart rate. These findings represent a complete quantitative description of use-dependent QUIN CD in vivo and provide a firm foundation for characterizing antiarrhythmic drug action under physiologic and pathologic conditions.
Sensitization to Specific Allergens in Early Childhood Alters Asthma Risk
Authors: D.J. Stoltz, D.J. Jackson, C.J. Tisler, D.F. DaSilva, K.A. Roberg, E.L. Anderson, M.D. Evans, R.E. Gangnon, J.E. Gern, R.F. Lemanske
Journal: Journal of Allergy and Clinical Immunology (2010)
Sustained virological response with telaprevir in 1078 patients with advanced hepatitis C: The international telaprevir access program
Authors: Massimo Colombo, Simone Strasser, Christophe Moreno, Paulo Abrao Ferreira, Petr Urbanek, Inmaculada Fernández, Djamal Abdurakmonov, Adrian Streinu-Cercel, Anke Verheyen, Wafae Iraqi, Ralph DeMasi, Andrew Hill, Isabelle Lonjon-Domanec, Heiner Wedemeyer
Journal: Journal of Hepatology (2014)
Dynamic Volume Perfusion Computed Tomography Parameters versus RECIST for the Prediction of Outcome in Lung Cancer Patients Treated with Conventional Chemotherapy
Authors: Sonja Sudarski, Jingyun Shi, Gerald Schmid-Bindert, Christian Manegold, Lothar R. Pilz, Caicun Zhou, Stefan O. Schoenberg, Thomas Henzler
Journal: Journal of Thoracic Oncology (2014)

To compare dynamic volume perfusion computed tomography (dVPCT) parameters with Response Evaluation Criteria in Solid Tumors (RECIST 1.1) for prediction of therapy response and overall survival (OS) in non-small-cell lung cancer (NSCLC) and small-cell lung cancer (SCLC) patients treated with conventional chemotherapy.A total of 173 lung cancer patients (131 men; 61 ± 10 years) undergoing dVPCT before (T1) and after chemotherapy (T2) and follow-up were prospectively included. dVPCT-derived blood flow, blood volume, mean transit time, and permeability (PERM) were assessed, compared between NSCLC and SCLC and patients' response to therapy was determined according to RECIST 1.1.One hundred of one hundred and seventy-three patients underwent dVPCT at T1 and T2 within a median of 44 (range, 31-108) days. dVPCT values were differing in NSCLC and SCLC, but were not significantly differing between patients with partial response, stable, or progressive disease. Eighty-five patients (NSCLC = 72 and SCLC = 13) with a follow-up for greater than or equal to 6 months were analyzed for OS. Fifty-six of eighty-five patients died during follow-up. Receiver operating characteristic analysis determined T1/T2 with highest predictive values regarding OS for blood flow, blood volume, mean transit time, and permeability (area under the curve: 0.53, 0.61, 0.54, and 0.53, respectively, all p > 0.05). Kaplan-Meier statistics revealed OS of patient groups assigned according to dVPCT T1/T2 cutoff values was not differing for neither dVPCT parameter, whereas RECIST groups significantly differed in OS (p = 0.02). Cox proportional hazards regression determined progressive disease status to independently predict OS (p = 0.004), while none of the dVPCT parameters did so.dVPCT values, differ between NSCLC and SCLC, are not related to RECIST 1.1 classification and do not improve OS prediction in lung cancer patients treated with conventional chemotherapy.
Transport of residual endocytosed products into terminal lysosomes occurs slowly in rat liver endothelial cells
Authors: Turid Hellevik, Inigo Martinez, Randi Olsen, Ban-Hock Toh, Paul Webster, Bård Smedsrød
Journal: Hepatology (1998)

Receptor-mediated endocytosis of circulating collagen is a major physiological scavenger function of the liver endothelial cell and an important catabolic event in the complete turnover of this abundant connective tissue protein. In the present study, transport of collagen through the endocytic pathway was investigated in cultured liver endothelial cells. Collagen conjugated to fluorescein isothiocyanate, to allow detection of the ligand by fluorescence and immunoelectron microscopy, was found sequentially in three different organelles that compose the basic degradative endocytic pathway of eukaryotic cells: early endosomes, late endosomes, and terminal lysosomes. Early endosomes were identified as vesicles positive for early endosome antigen 1 (EEA1). Late endosomes were distinguished as structures positive for the late endosomal/lysosomal marker rat lysosomal membrane glycoprotein 120, but negative for EEA1 and lysosomally targeted BSA-gold. Lysosomes were defined by their content of BSA-gold, injected 24 hours before isolation of cells. Coated pits and coated vesicles mediated an extremely rapid internalization. Shortly after internalization and during the first 20 minutes, ligand was found in early endosomes. From 20 minutes on, ligand started to appear in late endosomes (23%), and by 2 hours the transfer was largely complete (82.5%). Only 2.5% of ligand was transferred to the lysosomes after 2 hours, and this number slowly increased to 21% and 53% after 6 and 16 hours, respectively. We conclude that 1) EEA1 is a useful marker for tracing early events of endocytosis in liver endothelial cells; 2) in contrast to the rapid internalization, transit of internalized ligand through early sorting endosomes generally takes from 20 minutes to 2 hours; and 3) exit from the late endosomes is very slow, requiring several hours.
P1126 IMPACT OF SAFETY-RELATED DOSE REDUCTIONS AND DISCONTINUATIONS (SR-RD) ON SUSTAINED VIROLOGICAL RESPONSE (SVR) IN TREATMENT-NAIVE CHRONIC HEPATITIS C PATIENTS RECEIVING PEGINTERFERON ALFA-2a/RIBAVIRIN: RESULTS FROM GUARD-C
Authors: G.R. Foster, C. Coppola, M. Curescu, M. Derbala, G. Esmat, P. Ferenci, R. Flisiak, G. Lengyel, A. Mangia, A. Orlandini, K.R. Reddy, M. Rodriguez-Torres, M.L. Shiffman, I. Sporea, L. Tallarico, S. Ahlers, G. Bakalos, C. Wat, T. Hassanein
Journal: Journal of Hepatology (2014)
Expression of the skin‐homing receptor in peripheral blood lymphocytes from subjects with nonimmediate cutaneousallergic drug reactions
Authors: M. Blanca, M. J. Torres, L. Leyva, C. Mayorga, S. Posadas, L. Gonzalez, J. Fernández, C. Juarez, L. F. Santamaria
Journal: Allergy (2000)

Background: In nonimmediate cutaneous reactions to drugs, the skin is the organ most frequently involved, and T cells may play a relevant role. T cells related to skin immune responses express the cutaneous lymphocyte‐associated antigen (CLA), the skin‐homing receptor. Methods: We studied the expression of the CLA in peripheral blood T cells from nine subjects with exanthematous reactions induced by β‐lactams ( 4 ), phenytoin ( 2 ), propyphenazone ( 1 ), spiramycin plus metronidazol ( 1 ), and captopril plus tiazide ( 1 ). The cutaneous symptoms appeared at least 6 h after drug intake. CLA expression was evaluated by flow cytometry at the time of the reaction (T1) and 1 month later (T2). HLA‐DR activation marker expression was also evaluated at T1. In four patients, it was necessary to readminister the culprit drug to establish a causal relationship, and sequential estimation of the markers was performed. Two control groups were included: healthy controls and subjects exposed to the culprit drugs with good tolerance. Values were compared by nonparametric statistics. Results: The expression of circulating CLA+ T cells at T1 was increased compared to healthy controls (median=20.4 vs 9.4) ( P &lt;0.001), and the patients also expressed increased levels of HLA‐DR (median=3.8) ( P &lt;0.005). Comparison between T1 and T2 (median=11.2) also showed differences in levels of CLA+ T cells ( P &lt;0.01). The patients re‐exposed to the culprit drug showed an increase followed by a decrease of circulating CLA+ T cells ( P &lt;0.05) and CLA+ HLA‐DR+( P &lt;0.05) paralleling the symptoms. Conclusions: These data support the immunologic nature of delayed skin reactions to drugs, and suggest that these CLA+ T cells parallel the disease evolution and may participate in the pathophysiologic mechanisms.
Assessing the risk of violence in patients
Authors: J. Shaw
Journal: BMJ (2000)

Papers p 1112 

Is it possible to predict violence by patients in clinical practice? Politicians are all too ready to assume that it is and that healthcare professionals are at fault when a mentally ill person commits a violent act. Epidemiological approaches examining the inter-relationship between violence and mental illness have suggested that an association exists but that it is small.1–3 Fifteen years ago research suggested that clinicians were more often wrong than right in their risk predictions4 but more recent studies have shown that clinicians are getting better at predicting risk of violence, albeit in the short term.5

An influential longitudinal cohort study of psychiatric inpatients from the United States showed that the one year prevalence rate of violence was 18% for those with major mental disorder and 31% for patients with comorbid substance misuse disorder.6 Actuarial and clinical research studies have identified risk factors associated with violence drawn from a variety of domains. Key risk factors include demographic factors (being male, young, and in the lowest socioeconomic class),1 a history of previous violence, …
Treatment of pulmonary disease caused by opportunist mycobacteria.
Authors: J Banks
Journal: Thorax (1989)

Opportunist mycobacterial infections localised to the chest may be treated with combinations of standard antimycobacterial drugs. The combination of rifampicin and ethambutol seems to be particularly effective, both in vivo and in vitro. In vitro sensitivity testing with single drugs may have a role in the future when the levels of in vitro resistance compatible with the clinical response to treatment are eventually established. Sensitivity testing against drugs in combination may prove useful for modifying treatment regimens in those patients who either fail to respond to initial chemotherapy or relapse. Further evidence on this will, it is hoped, emerge from the prospective studies currently in progress.
Pulmonary hypertension in systemic lupus erythematosus.
Authors: R A Asherson, C G Mackworth-Young, M L Boey, R G Hull, A Saunders, A E Gharavi, G R Hughes
Journal: BMJ (1983)

Controlled trial of medical treatment of active chronic otitis mediaActive chronic otitis media is a common condition affecting 0 6%,' of adults in the United Kingdom.Initial management is usually by general practitioners, who annually prescribe systemic and topical antibiotics on at least 178 000 and 73 000 occasions respectively (unpublished observations).Despite this there have been few studies of the efficacy of antibiotics,'-4 and no study has included a control group of untreated patients or of patients treated solely by aural toilet.We undertook a controlled study comparing appropriate systemic or topical antibiotic treatment with weekly aural toilet and insufflation of boric acid and iodine powder.