Managing People at High Risk for Diabetes
Authors: William H. Herman, Thomas J. Hoerger, Katherine Hicks, Michael Brandle, Stephen W. Sorensen, Ping Zhang, Michael M. Engelgau, Richard F. Hamman, David G. Marrero, Ronald T. Ackermann, Robert E. Ratner
Journal: Annals of Internal Medicine (2006)

Letters3 January 2006Managing People at High Risk for DiabetesWilliam H. Herman, MD, MPH, Thomas J. Hoerger, PhD, Katherine Hicks, MS, Michael Brandle, MD, MS, Stephen W. Sorensen, PhD, Ping Zhang, PhD, Michael M. Engelgau, MD, MS, Richard F. Hamman, MD, DrPH, David G. Marrero, PhD, Ronald T. Ackermann, MD, MPH, and Robert E. Ratner, MDWilliam H. Herman, MD, MPHFrom the University of Michigan Health System, Ann Arbor, MI 48109; RTI International, Research Triangle Park, NC 27599; Kantonsspital St. Gallen, 9007 St. Gallen, Switzerland; Centers for Disease Control and Prevention, Atlanta, GA 30341; University of Colorado Health Sciences Center, Denver, CO 80262; Indiana University School of Medicine, Indianapolis, IN 46202; and Medstar Research Institute, Hyattsville, MD 20783., Thomas J. Hoerger, PhDFrom the University of Michigan Health System, Ann Arbor, MI 48109; RTI International, Research Triangle Park, NC 27599; Kantonsspital St. Gallen, 9007 St. Gallen, Switzerland; Centers for Disease Control and Prevention, Atlanta, GA 30341; University of Colorado Health Sciences Center, Denver, CO 80262; Indiana University School of Medicine, Indianapolis, IN 46202; and Medstar Research Institute, Hyattsville, MD 20783., Katherine Hicks, MSFrom the University of Michigan Health System, Ann Arbor, MI 48109; RTI International, Research Triangle Park, NC 27599; Kantonsspital St. Gallen, 9007 St. Gallen, Switzerland; Centers for Disease Control and Prevention, Atlanta, GA 30341; University of Colorado Health Sciences Center, Denver, CO 80262; Indiana University School of Medicine, Indianapolis, IN 46202; and Medstar Research Institute, Hyattsville, MD 20783., Michael Brandle, MD, MSFrom the University of Michigan Health System, Ann Arbor, MI 48109; RTI International, Research Triangle Park, NC 27599; Kantonsspital St. Gallen, 9007 St. Gallen, Switzerland; Centers for Disease Control and Prevention, Atlanta, GA 30341; University of Colorado Health Sciences Center, Denver, CO 80262; Indiana University School of Medicine, Indianapolis, IN 46202; and Medstar Research Institute, Hyattsville, MD 20783., Stephen W. Sorensen, PhDFrom the University of Michigan Health System, Ann Arbor, MI 48109; RTI International, Research Triangle Park, NC 27599; Kantonsspital St. Gallen, 9007 St. Gallen, Switzerland; Centers for Disease Control and Prevention, Atlanta, GA 30341; University of Colorado Health Sciences Center, Denver, CO 80262; Indiana University School of Medicine, Indianapolis, IN 46202; and Medstar Research Institute, Hyattsville, MD 20783., Ping Zhang, PhDFrom the University of Michigan Health System, Ann Arbor, MI 48109; RTI International, Research Triangle Park, NC 27599; Kantonsspital St. Gallen, 9007 St. Gallen, Switzerland; Centers for Disease Control and Prevention, Atlanta, GA 30341; University of Colorado Health Sciences Center, Denver, CO 80262; Indiana University School of Medicine, Indianapolis, IN 46202; and Medstar Research Institute, Hyattsville, MD 20783., Michael M. Engelgau, MD, MSFrom the University of Michigan Health System, Ann Arbor, MI 48109; RTI International, Research Triangle Park, NC 27599; Kantonsspital St. Gallen, 9007 St. Gallen, Switzerland; Centers for Disease Control and Prevention, Atlanta, GA 30341; University of Colorado Health Sciences Center, Denver, CO 80262; Indiana University School of Medicine, Indianapolis, IN 46202; and Medstar Research Institute, Hyattsville, MD 20783., Richard F. Hamman, MD, DrPHFrom the University of Michigan Health System, Ann Arbor, MI 48109; RTI International, Research Triangle Park, NC 27599; Kantonsspital St. Gallen, 9007 St. Gallen, Switzerland; Centers for Disease Control and Prevention, Atlanta, GA 30341; University of Colorado Health Sciences Center, Denver, CO 80262; Indiana University School of Medicine, Indianapolis, IN 46202; and Medstar Research Institute, Hyattsville, MD 20783., David G. Marrero, PhDFrom the University of Michigan Health System, Ann Arbor, MI 48109; RTI International, Research Triangle Park, NC 27599; Kantonsspital St. Gallen, 9007 St. Gallen, Switzerland; Centers for Disease Control and Prevention, Atlanta, GA 30341; University of Colorado Health Sciences Center, Denver, CO 80262; Indiana University School of Medicine, Indianapolis, IN 46202; and Medstar Research Institute, Hyattsville, MD 20783., Ronald T. Ackermann, MD, MPHFrom the University of Michigan Health System, Ann Arbor, MI 48109; RTI International, Research Triangle Park, NC 27599; Kantonsspital St. Gallen, 9007 St. Gallen, Switzerland; Centers for Disease Control and Prevention, Atlanta, GA 30341; University of Colorado Health Sciences Center, Denver, CO 80262; Indiana University School of Medicine, Indianapolis, IN 46202; and Medstar Research Institute, Hyattsville, MD 20783., and Robert E. Ratner, MDFrom the University of Michigan Health System, Ann Arbor, MI 48109; RTI International, Research Triangle Park, NC 27599; Kantonsspital St. Gallen, 9007 St. Gallen, Switzerland; Centers for Disease Control and Prevention, Atlanta, GA 30341; University of Colorado Health Sciences Center, Denver, CO 80262; Indiana University School of Medicine, Indianapolis, IN 46202; and Medstar Research Institute, Hyattsville, MD 20783.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-144-1-200601030-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We are writing in response to the report by Eddy and colleagues (1). We have several questions about their simulations, conclusions, and representation of our work. Unlike the authors, we found a favorable cost-effectiveness ratio for the Diabetes Prevention Program lifestyle intervention (2).The Archimedes model may or may not represent a quantum leap in diabetes modeling. For simulation models to aid decision making, they must be transparent and have face validity. By using complex differential equations fitted to empirical data, the Archimedes model can simulate an infinite number of physiologic processes. Unfortunately, the equations governing disease ...References1. Eddy DM, Schlessinger L, Kahn R. Clinical outcomes and cost-effectiveness of strategies for managing people at high risk for diabetes. Ann Intern Med. 2005;143:251-64. [PMID: 16103469] LinkGoogle Scholar2. Herman WH, Hoerger TJ, Brandle M, Hicks K, Sorensen S, Zhang P, et al. The cost-effectiveness of lifestyle modification or metformin in preventing type 2 diabetes in adults with impaired glucose tolerance. Ann Intern Med. 2005;142:323-32. [PMID: 15738451] LinkGoogle Scholar3. Knowler WC, Pettitt DJ, Savage PJ, Bennett PH. Diabetes incidence in Pima indians: contributions of obesity and parental diabetes. Am J Epidemiol. 1981;113:144-56. [PMID: 7468572] CrossrefMedlineGoogle Scholar4. Ferrannini E, Nannipieri M, Williams K, Gonzales C, Haffner SM, Stern MP. Mode of onset of type 2 diabetes from normal or impaired glucose tolerance. Diabetes. 2004;53:160-5. [PMID: 14693710] CrossrefMedlineGoogle Scholar5. Ward WK, Beard JC, Halter JB, Pfeifer MA, Porte D. Pathophysiology of insulin secretion in non–insulin-dependent diabetes mellitus. Diabetes Care. 1984;7:491-502. [PMID: 6094129] CrossrefMedlineGoogle Scholar6. Saaddine JB, Engelgau MM, Beckles GL, Gregg EW, Thompson TJ, Narayan KM. A diabetes report card for the United States: quality of care in the 1990s. Ann Intern Med. 2002;136:565-74. [PMID: 11955024] LinkGoogle Scholar7. Hamman RF. Retinopathy in recent-onset diabetes and persons at high risk of diabetes in the Diabetes Prevention Program: late-breaking clinical trials [Abstract]. San Diego: 65th Annual Meeting of the American Diabetes Association; 2005. Google Scholar Author, Article, and Disclosure InformationAuthors: William H. Herman, MD, MPH; Thomas J. Hoerger, PhD; Katherine Hicks, MS; Michael Brandle, MD, MS; Stephen W. Sorensen, PhD; Ping Zhang, PhD; Michael M. Engelgau, MD, MS; Richard F. Hamman, MD, DrPH; David G. Marrero, PhD; Ronald T. Ackermann, MD, MPH; Robert E. Ratner, MDAffiliations: From the University of Michigan Health System, Ann Arbor, MI 48109; RTI International, Research Triangle Park, NC 27599; Kantonsspital St. Gallen, 9007 St. Gallen, Switzerland; Centers for Disease Control and Prevention, Atlanta, GA 30341; University of Colorado Health Sciences Center, Denver, CO 80262; Indiana University School of Medicine, Indianapolis, IN 46202; and Medstar Research Institute, Hyattsville, MD 20783.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoA Diabetes Report Card for the United States: Quality of Care in the 1990s Jinan B. Saaddine , Michael M. Engelgau , Gloria L. Beckles , Edward W. Gregg , Theodore J. Thompson , and K.M. Venkat Narayan The Cost-Effectiveness of Lifestyle Modification or Metformin in Preventing Type 2 Diabetes in Adults with Impaired Glucose Tolerance William H. Herman , Thomas J. Hoerger , Michael Brandle , Katherine Hicks , Stephen Sorensen , Ping Zhang , Richard F. Hamman , Ronald T. Ackermann , Michael M. Engelgau , and Robert E. Ratner , for the Diabetes Prevention Program Research Group*Clinical Outcomes and Cost-Effectiveness of Strategies for Managing People at High Risk for Diabetes David M. Eddy , Leonard Schlessinger , and Richard Kahn Managing People at High Risk for Diabetes David M. Eddy , Leonard Schlessinger , and Richard Kahn Metrics Cited byUse of community-based participatory research in primary care to improve healthcare outcomes and disparities in careScreening for type 2 diabetes: an update of the evidenceEconomic Evaluation of Lifestyle Interventions for Preventing Diabetes and Cardiovascular DiseasesResearching how to realize the potential of diabetes preventionIs prevention of Type-2 diabetes feasible and efficient in primary care? 3 January 2006Volume 144, Issue 1Page: 66-67KeywordsBlood plasmaDiabetes preventionGlucoseHbA1cHealth economicsHyperglycemiaMarkov modelsReproducibilityRetinopathyType 2 diabetes ePublished: 3 January 2006 Issue Published: 3 January 2006 Copyright & PermissionsCopyright © 2006 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...