More on Antimicrobials in Renal Failure
Authors: CALVIN M. KUNIN
Journal: Annals of Internal Medicine (1968)

Editorial Notes1 August 1968More on Antimicrobials in Renal FailureCALVIN M. KUNIN, M.D.CALVIN M. KUNIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-69-2-397 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA table summarizing recommended doses and factors governing serum levels of antimicrobial agents in patients with renal disease was published last year in the ANNALS (1). Since then, more information has been provided on the fate of gentamycin, nitrofurantoin, chloramphenicol, and colistin in the presence of renal disease.Gentamycin is closely related to the aminoglycoside antibiotics streptomycin, neomycin, and kanamycin and has shown promise for use in patients with serious gram negative infections including those due to Pseudomonas. It also has activity against many gram positive organisms.The most serious adverse effect is severe damage to vestibular function seen most...References1. KUNIN CM: A guide to use of antibiotics in patients with renal disease. A table of recommended doses and factors governing serum levels. Ann. Intern. Med. 67: 151, 1967. LinkGoogle Scholar2. BULGERSIDELLKIRBY RJSWM: Laboratory and clinical studies of gentamicin, a new broad-spectrum antibiotic. Ann. Intern. Med. 59: 593, 1963. LinkGoogle Scholar3. JAOJACKSON RLGG: Gentamicin sulfate, a new antibiotic against gram-negative bacilli. Laboratory, pharmacological, and clinical evaluation. JAMA 189: 817, 1964. CrossrefMedlineGoogle Scholar4. CURTISMCDONALDWESTON JRSJJH: Parenteral administration of gentamicin in renal failure: patients undergoing intermittent haemodialysis. Brit. Med. J. 1: 537, 1967. CrossrefMedlineGoogle Scholar5. GINGELLWATERWORTH JCPM: Dose of gentamicin in patients with normal renal function and renal impairment. Brit. Med. J. 2: 19, 1968. CrossrefMedlineGoogle Scholar6. LIPPMANWRABELREESHOYT RWCJRR: A theory concerning recurrence of urinary infection: prolonged administration of nitrofurantoin for prevention. J. Urol. 80: 77, 1958. CrossrefMedlineGoogle Scholar7. SCHLEGELGOFFO'DELL JUJBRM: Bacteriuria and chronic renal disease. Trans. Amer. Ass. Genitourin. Surg. 59: 32, 1967. MedlineGoogle Scholar8. SACHSGEERNOELLKUNIN JTPCM: Effect of renal function on urinary recovery or orally administered nitrofurantoin. New Eng. J .Med. 278: 1032, 1968. CrossrefMedlineGoogle Scholar9. LINDBERGNILSSONBUCHTKALLINGS AALHHLO: Concentration of chloramphenicol in the urine and blood in relation to renal function. Brit. Med. J. 2: 724, 1966. CrossrefMedlineGoogle Scholar10. GOODWINFRIEDMAN NJEA: The effects of renal impairment, peritoneal dialysis, and hemodialysis on serum sodium colistimethate levels. Ann. Intern. Med. 68: 984, 1968. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Virginia School of Medicine Charlottesville, Va. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByHistory, Chemistry and Antibacterial SpectrumMiscellaneous agentsTranslation of pharmacokinetics to clinical medicineTranslation of Pharmacokinetics to Clinical MedicineMultiple Dose Kinetics and Drug Dosage in Patients with Kidney DiseaseAktuelle Probleme der Pathogenese und Therapie verschiedener Schockformen in der inneren Medizin (Symposion)Infectious diseases. Annual review of significant publications.Emergency Treatment of Severe Bacterial InfectionCOLISTIN SULFATE VERSUS SODIUM COLISTIMETHATENORMA J. GOODWIN, M.D. 1 August 1968Volume 69, Issue 2Page: 397-398KeywordsAntibioticsAntimicrobialsChloramphenicolNeomycinsPseudomonasPseudomonas infectionsRenal diseasesRenal failureStreptococcal infectionsStreptomycin Issue Published: 1 August 1968 PDF DownloadLoading ...