tbuckley/cabot-search huggingface dataset:
Angiogenic and prothrombotic markers in extensive slow-flow vascular malformations: implications for antiangiogenic/antithrombotic strategies
Authors: P. Redondo, L. Aguado, M. Marquina, J.A. Paramo, A. Sierra, A. Sánchez-Ibarrola, A. Martínez-Cuesta, J. Cabrera
Journal: British Journal of Dermatology (2009)

Venous and combined malformations are slow-flow haemodynamically inactive lesions that are present at birth and worsen slowly with advancing age, showing no tendency towards involution. The pathogenesis of vascular anomalies has not been fully elucidated, but their formation and progression are closely related to angiogenesis. Localized intravascular coagulation associated with venous or combined malformations is characterized by low fibrinogen, high D-dimers, and normal platelet count.To assess the relationship of angiogenic factors with prothrombotic and endothelial damage/dysfunction markers in patients with extensive slow-flow vascular malformations.A 2-year study (2005-2007) included 31 consecutive patients with extensive slow-flow vascular malformations from one centre.Serum levels of the endothelial receptor tyrosine kinase TIE-2, matrix metalloproteinase (MMP)-9 and angiopoietin (Ang)-2 and plasma levels of D-dimer, plasminogen activator inhibitor type 1 (PAI-1), tissue-type plasminogen activator and von Willebrand factor (vWf) were significantly increased in patients compared with healthy controls, whereas serum levels of vascular endothelial growth factor (VEGF)-C, VEGF-D, MMP-2, Ang-1, platelet-derived growth factor (PDGF)-AB and PDGF-BB were significantly decreased in patients compared with controls. A strong positive correlation was present between Ang-1 and PDGF-AB levels (r = 0.63, P < 0.001), between PDGF-AB and PDGF-BB levels (r = 0.67, P < 0.001), and between fibrinogen and PAI-1 levels (r = 0.41, P = 0.031). A strong negative correlation was present between Ang-1 and vWf levels (r = -0.48, P = 0.006), between D-dimer and fibrinogen levels (r = -0.71, P < 0.001), and between PDGF-AB and vWf levels (r = -0.42, P = 0.017).These findings suggest that angiogenic, coagulation and endothelial damage/dysfunction markers are possibly linked in pathogenesis of extensive slow-flow vascular malformations, and might have therapeutic implications.
THE INFLUENCE WHICH THE ACQUISITION OF TROPICALTERRITORY BY THE UNITED STATES HAS HAD, AND IS LIKELY TO HAVE, ON AMERICAN MEDICINE.ORATION ON STATE MEDICINE AT THE FIFTY-SIXTH ANNUAL SESSION OF THE AMERICAN MEDICAL ASSOCIATION, PORTLAND, OREGON, JULY 11-14, 1905.
Authors: GEORGE BLUMER
Journal: JAMA (1905)

It is a custom in many universities, both in this country and in Europe, to allow each professor leave of absence during every seventh year of service. This custom is doubtless based on the Sabbatical year of the Pentateuchal codes, an institution which demanded that the fields be allowed to lie fallow every seventh year. It is a question whether the Sabbatical year, as an institution, could not with benefit be introduced into matters medical, and whether we might not profit by resting every seventh year, and devoting our time, not to the strenuous throes of medical existence, but to a calm, dispassionate review of the progress of medicine in the preceding septennate, and the factors which have influenced that progress. With this idea in view I have chosen to speak to-day on an aspect of our medical progress which is now in its Sabbatical year. It is at present
Hydration and preferential molecular adsorption on titanium in vitro
Authors: Kevin E. Healy, Paul Ducheyne
Journal: Biomaterials (1992)

Surface sensitive spectroscopies, Auger electron and X-ray photoelectron (XPS), were used to determine changes in titanium oxide composition, oxide stoichiometry and adsorbed surface species as a function of exposure to human serum in a balanced electrolyte (serum/SIE) and 8.0 mM ethylenediaminetetraacetic acid in a balanced electrolyte (EDTA/SIE) at 37°C. Before immersion, the oxide was near ideal TiO2, covered by two types of hydroxyl groups: acidic OH(s) with oxygens doubly coordinated to titanium and basic Ti-OH groups singly coordinated. After extended exposure to both solutions, up to 5000 h (ca. 208 d), the surface concentration of OH groups increased and non-elemental P appeared. The P LVV Auger transition and P 2p spectra indicated the peak positions were similar to reference phosphate compounds. The adsorbed phosphate species were presumed to be either Ti-H2PO4 or Ti-HPO4−. The XPS data suggested that a lipoprotein and/or glycolipid film was adsorbed to the specimens exposed to serum/SIE. Analysis of the preferential lipoprotein/glycolipid adsorption using electrostatic bonding concepts contributed to the refinement of the hierarchical model for the Ti-tissue interface. The salient features are that Ti metal is not in direct contact with the biological milieu, rather there is a gradual transition from the bulk metal, near-stoichiometric oxide, Ca and P substituted hydrated oxide, adsorbed lipoproteins and glycolipids, proteoglycans, collagen filaments and bundles to cells.
Association Between Statin Medications and Mortality, Major Adverse Cardiovascular Event, and Amputation-Free Survival in Patients With Critical Limb Ischemia
Authors: Gregory G. Westin, Ehrin J. Armstrong, Heejung Bang, Khung-Keong Yeo, David Anderson, David L. Dawson, William C. Pevec, Ezra A. Amsterdam, John R. Laird
Journal: Journal of the American College of Cardiology (2013)
Comparison of treatment strategies for patients with intestinal diffuse large B-cell lymphoma: surgical resection followed by chemotherapy versus chemotherapy alone
Authors: Seok Jin Kim, Hye Jin Kang, Jin Seok Kim, Sung Yong Oh, Chul Won Choi, Soon Il Lee, Jong Ho Won, Min Kyoung Kim, Jung Hye Kwon, Yeung-Chul Mun, Jae-Yong Kwak, Jung Mi Kwon, In Gyu Hwang, Hyo Jung Kim, Jinny Park, Sukjoong Oh, Jooryung Huh, Young Hyeh Ko, Cheolwon Suh, Won Seog Kim
Journal: Blood (2010)
Fetal Exposure of Rhesus Macaques to Bisphenol A Alters Cellular Development of the Conducting Airway by Changing Epithelial Secretory Product Expression
Authors: Laura S. Van Winkle, Shannon R. Murphy, Miriam V. Boetticher, Catherine A. VandeVoort
Journal: Environmental Health Perspectives (2013)

Bisphenol A (BPA) exposure early in life results in organizational changes in reproductive organs, but the effect of BPA on conducting airway cellular maturation has not been studied. Late gestation is characterized by active differentiation of secretory cells in the lung epithelium.We evaluated the hypothesis that BPA exposure disrupts epithelial secretory cell development in the fetal conducting airway of the rhesus macaque.We exposed animals to BPA during either the second (early term) or the third (late term) trimester. There were four treatment groups: a) sham control early term, b) sham control late term, c) BPA early term (BPA-early), and d) BPA late term (BPA-late). Because cellular maturation occurs nonuniformly in the lung, we defined mRNA and protein expression by airway level using microdissection.BPA exposure of the dam during late term significantly accelerated secretory cell maturation in the proximal airways of the fetus; both Clara cell secretory protein (CCSP) and MUC5AC/5B mRNA and protein expression increased.BPA exposure during late gestation accelerates secretory cell maturation in the proximal conducting airways. We identified a critical window of fetal susceptibility for BPA effects on lung epithelial cell maturation in the third trimester. This is of environmental health importance because increases in airway mucins are hallmarks of a number of childhood lung diseases that may be affected by BPA exposure.
Iron deficiency in the rat. Physiological and biochemical studies of muscle dysfunction.
Authors: C A Finch, L R Miller, A R Inamdar, R Person, K Seiler, B Mackler
Journal: Journal of Clinical Investigation (1976)

Work performance on a treadmill has been evaluated in normal and iron-deficient rats. Anemia was removed as a variable by adjusting the hemoglobin of all animals to the same concentration. At a hemoglobin compatible with normal work performance, iron-deficient animals showed a marked impairment of running ability as compared to control animals. Iron therapy corrected the disability within 4 days. Concentrations of the cytochrome pigments and myoglobin, and rates of oxidative phosphorylation with pyruvate-malate, succinate, and alpha-glycerophosphate as substrates were all reduced in mitochondrial preparations from skeletal muscle of iron-deficient rats, but only the rate of phosphorylation with alpha-glycerophosphate as substrate increased significantly and in parallel with the recovery in work performance of the iron-deficient rats treated with iron dextran.
Experimental Induction of Iso-Immune Hemolytic Anemia in Man by Transfusion of Unusually Potent Anti-Rh Antibodies.
Authors: H. S. Bowman
Journal: Annals of Internal Medicine (1961)

s1 May 1961Experimental Induction of Iso-Immune Hemolytic Anemia in Man by Transfusion of Unusually Potent Anti-Rh Antibodies.H. S. Bowman, M.D., F.A.C.P., J. F. Mohn, M.D., R. M. Lambert, F. W. Brason, M.D.H. S. Bowman, M.D., F.A.C.P.Search for more papers by this author, J. F. Mohn, M.D.Search for more papers by this author, R. M. LambertSearch for more papers by this author, F. W. Brason, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-54-5-1061_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn an earlier study of experimental transfusion of donor plasma containing blood group antibodies into incompatible normal human recipients, a single ACD plasma containing exceptional anti-CD antibodies induced iso-immune hemolytic anemia in a CwDe/Ce (R1wR1) volunteer. The hematologic and immunologic observations made closely paralleled those found in naturally-occurring warm-antibody type acquired hemolytic anemia, and indicated that further detailed studies on additional recipients transfused with this unique anti-CD plasma might provide some insight into the pathogenesis of the spontaneously-occurring disorder.The equivalent of a single unit of plasma of a sterile pool of three bleedings from the same donor was transfused... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1961Volume 54, Issue 5Page: 1061-1061KeywordsAntibodiesBlood donorsBlood groupsBlood plasmaHemolytic anemiaHemorrhagePathogenesis Issue Published: 1 May 1961 PDF downloadLoading ...
Practicing medicine on the edge of purgatory
Authors: Elizabeth Rasche González
Journal: JAMA (1980)

Again this year, in our world, the enormity of one population's plight staggers the "civilized" imagination. The devastation of Kampuchea (the country Westerners call Cambodia) evokes the Nazi holocaust (<i>JAMA</i>243:2161, 1980) or the wholesale slaughter of the Armenians by the Turks, for the death toll is now reputedly in the millions. Within the minority who survive, a few bear witness to the nightmare they have fled. Escaping their native land through a web of military patrols, they often arrive at the border camps in skeletal condition, their severe malnutrition complicated by diverse infections and infestations, their families decimated, their emotions necessarily anesthetized. At the most makeshift camps—those in clearly disputed territory—the only medical facilities are day hospitals. There the sick can be treated and fed, but they must be evicted at night, even when this means removing an intravenous (IV) line. These way stations may be primitive by design, to discourage further
Reconstruction of dislocated hips in children with cerebral palsy
Authors: J D Spencer
Journal: BMJ (1999)

Children who suffer from cerebral palsy and do not walk before the age of 5 have a 58% incidence of hip dislocation (44% bilateral, 14% unilateral).1Other factors involved in the causation of hip dislocation include four limb cerebral palsy2 and tightness of the adductor and iliopsoas muscles with concomitant weakness in the abductor muscles at the hip.3 Whatever the cause, reconstructing the hip in these children involves complex surgery, and parents and their doctors need to be aware that management is not straightforward.

Investigations used to detect dislocation include x rays of the pelvis and whole spine; from the former the physician or surgeon can document any progressive tendency of the hip to dislocate by measuring the migration percentage.4Such monitoring is important. Associated radiological features of hip dislocation are femoral neck anteversion, valgus femoral neck …
Vitamin E — A Radical Defense
Authors: Frank A. Oski
Journal: New England Journal of Medicine (1980)

Some view life as "just a bowl of cherries," and others perceive it as a series of attacks by free radicals that ultimately lead to our rancidity. It is for those who share this latter view that the article by Corash and his associates in this week's Journal will be of considerable interest.Free radicals differ from other chemical species in possessing an unpaired electron. Superoxide radicals (O2−) are produced within cells both by autooxidation of reduced electron-transferring components and by enzymatic processes.1 Their intrinsic reactivity and their ability to generate even more potent oxidants when they interact . . .
It's a Boy?
Authors: John D. Crawford
Journal: New England Journal of Medicine (1974)

It has been said that the most important decision of our lives is one made for us without our conscious participation, by a stranger, and taken in a trice. This, of course, is the assignment of gender role. Even an amateur can make the decision with a degree of correctness rivaling the purity of Ivory soap. "Correctness" is used advisedly for the right gender-role assignment may not be concordant with sex as judged by cytogenetic study, the morphology of the gonads, or the biochemical nature of their hormonal products. Who, for example, would question the correctness of female-gender-role assignment in . . .
Survival of memory T cells specific for Japanese cypress pollen allergen is maintained by cross‐stimulation of putative pectate lyases from other plants
Authors: Y. Nakamura, S. Takagi, M. Suzuki, H. Ito, S. Murakami, N. Ohta
Journal: Allergy (2001)

In view of recent studies on the mechanisms of the survival of peripheral memory T cells, we tested the biologic role of pectate lyase, a pectin-degrading enzyme, as the cross-reactive antigen required for the recurring survival signals for human T cells specific for Cha o 1, a pollen allergen molecule of the Japanese cypress. We determined a 16-mer epitope peptide for the T-cell clone, and prepared synthetic oligopeptides of homologous regions in putative pectate lyase of other plants. Of these homologous peptides, ZePel (Zinnia elegans), ban 17 (banana), and Amb a 1.1 (short ragweed) induced strong proliferative responses of the Cha o 1-specific T-cell clone in vitro. In addition, suboptimal doses of peptide homologs derived from banana and short ragweed enhanced the survival potency of this T-cell clone without detectable proliferative responses to the peptides. When there was no antigen stimulation, the T-cell clone decreased in viable cell number and lost antigen-specific proliferation activity on day 6 during in vitro incubation. On the other hand, T-cell clones incubated with these survival-inducing peptides maintained proliferative activity to Cha o 1 even on day 9. Serum derived from the donor patient did not contain detectable levels of IgE specific to banana or short ragweed by CAP-RAST. These results show that human T cells specific for pollen allergen seem to use cross-reactive pectate lyase peptides to deliver survival signals even in the absence of pollen allergen, and memory T cells maintained in such a manner might be functioning at the onset of allergic pollinosis, although pollen allergens are seasonal.
Naive T-cells in myelodysplastic syndrome display intrinsic human telomerase reverse transcriptase (hTERT) deficiency
Authors: L Yang, A Mailloux, D E Rollison, J S Painter, J Maciejewski, R L Paquette, T P Loughran, K McGraw, H Makishima, R Radhakrishnan, S Wei, X Ren, R Komrokji, A F List, P K Epling-Burnette
Journal: Leukemia (2012)
Role of the low density lipoprotein receptor in the flux of cholesterol through the plasma and across the tissues of the mouse.
Authors: Y Osono, L A Woollett, J Herz, J M Dietschy
Journal: Journal of Clinical Investigation (1995)

These studies were undertaken to quantify cholesterol balance across the plasma space and the individual organs of the mouse, and to determine the role of the low density lipoprotein receptor (LDLR) in these two processes. In the normal mouse (129 Sv), sterol was synthesized at the rate of 153 mg/d per kg body weight of which 78% occurred in the extrahepatic tissues while only 22% took place in the liver. These animals metabolized 7.1 pools of LDL-cholesterol (LDL-C) per day, and 79% of this degradation took place in the liver. Of this total turnover, the LDLR accounted for 88% while the remaining 12% was receptor independent. 91% of the receptor-dependent transport identified in these animals was located in the liver while only 38% of the receptor-independent uptake wsa found in this organ. When the LDLR was deleted, the LDL-C production rate increased 1.7-fold, LDL-C turnover decreased from 7.1 to 0.88 pools/d, and the plasma LDL-C level increased 14-fold, from 7 to 101 mg/dl. Despite these major changes in the circulating levels of LDL-C, however, there was no change in the rate of cholesterol synthesis in any extrahepatic organ or in the whole animal, and, further, there was no change in the steady-state cholesterol concentration in any organ. Thus, most extrahepatic tissues synthesize their daily sterol requirements while most LDL-C is returned directly to the liver. Changes in LDLR activity, therefore, profoundly alter the plasma LDL-C concentration but have virtually no affect on cholesterol balance across any extrahepatic organ, including the brain.
Hepatic Hemorrhage without Rupture in Preeclampsia
Authors: Kenneth J. Manas, Jack D. Welsh, Robert A. Rankin, David D. Miller
Journal: New England Journal of Medicine (1985)

HEPATIC hemorrhage with rupture is a serious complication of preeclampsia with a high maternal and perinatal mortality, and the literature states that surgical intervention is indicated.1 , 2 Patients with preeclampsia who have hepatic hemorrhage without rupture can present with similar signs and symptoms; however, the incidence, natural history, and therapy of this condition have not been well described. On the basis of limited experience, surgery has also been recommended in patients with hemorrhage but no rupture.3 , 4 The purpose of this report is to describe seven cases of hepatic hemorrhage associated with preeclampsia in which surgical repair was not required.MethodsSeven . . .
Zinc and the Special Senses
Authors: ROBERT M. RUSSELL
Journal: Annals of Internal Medicine (1983)

There is evidence that zinc is important for maintenance of the special senses: vision, taste, and smell. Rod function is impaired in zinc deficiency due partly to its role in vitamin A metabolism. However, optic nerve function may also be affected by zinc status. Microophthalmia, anophthalmia, and optic nerve abnormalities have all been found in the offspring of female rats fed zinc-deficient diets. Zinc deficiency clearly decreases taste acuity in both animals and humans. However, other nutritional and non-nutritional conditions also produce hypogeusia. There is limited evidence that zinc deficiency impairs olfactory acuity in humans. New approaches to the assessment of taste and smell abnormalities may provide reliable and reproducible associations between zinc deficiency and taste and smell defects.
Treatment with IMM-101 induces protective CD8+ T cell responses in clinically relevant models of pancreatic cancer
Authors: Androulla Elia, Louise Lincoln, Laura Brunet, Thorsten Hagemann
Journal: Journal for ImmunoTherapy of Cancer (2013)

Meeting abstracts Pancreatic cancer is an aggressive cancer with poor prognosis. Despite its low incidence, it is the 4th cause of cancer-related death in the US. Treatment options have only marginally improved on survival rates, which have remained low, with about 25% survival at 12 months and 5%
Effect of bile acids on electrical properties of rat colon: evaluation of an in-vitro model for secretion.
Authors: E J Schwiter, G W Hepner, R C Rose
Journal: Gut (1975)

A preparation of rat colon mucosa has been evaluated as a useful model to study effects of bile acids on the changes in short-circuit current and transmural electrical potential difference (pd) which others have associated with alterations in electrolyte transport. Using this preparation, it was found that bile acids were effective in increasing short-circuit current and pd when applied to the serosal, but not the mucosal, surface of the tissue. Furthermore, taurine-conjugated cholic acid, which has no demonstrable effect on the colon in vivo, was found to increase short-circuit current and pd significantly in the in-vitro preparation. These data indicate the limitations of the in-vitro model in studying the mechanism of bile acid-stimulated intestinal secretion.
Repolarizing K <sup>+</sup> Currents <i>I</i> <sub>TO1</sub> and <i>I</i> <sub>Ks</sub> Are Larger in Right Than Left Canine Ventricular Midmyocardium
Authors: Paul G. A. Volders, Karin R. Sipido, Edward Carmeliet, Roel L. H. M. G. Spätjens, Hein J. J. Wellens, Marc A. Vos
Journal: Circulation (1999)

The ventricular action potential exhibits regional heterogeneity in configuration and duration (APD). Across the left ventricular (LV) free wall, this is explained by differences in repolarizing K+ currents. However, the ionic basis of electrical nonuniformity in the right ventricle (RV) versus the LV is poorly investigated. We examined transient outward (ITO1), delayed (IKs and IKr), and inward rectifier K+ currents (IK1) in relation to action potential characteristics of RV and LV midmyocardial (M) cells of the same adult canine hearts.Single RV and LV M cells were used for microelectrode recordings and whole-cell voltage clamping. Action potentials showed deeper notches, shorter APDs at 50% and 95% of repolarization, and less prolongation on slowing of the pacing rate in RV than LV. ITO1 density was significantly larger in RV than LV, whereas steady-state inactivation and rate of recovery were similar. IKs tail currents, measured at -25 mV and insensitive to almokalant (2 micromol/L), were considerably larger in RV than LV. IKr, measured as almokalant-sensitive tail currents at -50 mV, and IK1 were not different in the 2 ventricles.Differences in K+ currents may well explain the interventricular heterogeneity of action potentials in M layers of the canine heart. These results contribute to a further phenotyping of the ventricular action potential under physiological conditions.