tbuckley/cabot-search huggingface dataset:
PMO-081 Enteral nutrition in the critically ill: the impact of nursing adherence to feeding protocols on the effectiveness of treatment in jordanian intensive care units
Authors: M T Al Kalaldeh
Journal: Gut (2012)

<h3>Introduction</h3> The aim of the study is to assess nurses9 adherence to enteral nutrition evidence-based guidelines in intensive care. <h3>Methods</h3> Mixed-methods design was employed. This abstract will show the results of the survey which was concerned with the practical issues, the nursing process, and enteral nutrition complications. A cluster sample recruited intensive care nurses (n=253) from different health care sectors in Jordan. <h3>Results</h3> Clinical nutrition is perceived by 79.7% of nurses as a secondary role. Nurses showed greater levels of knowledge and responsibility for “preventing complications” and “evaluation” than “assessment” and “identifying goals”. Tube position is still confirmed via unreliable measures such as air bubbling technique (mean 4.00, SD 1.14). The mean for measuring Gastric Residual Volume was above the mid-point (3.70, SD 1.33). However, there was inconsistency in recognising the limit, threshold and frequency of measuring this volume. Diarrhoea is the most frequent complication of enteral nutrition (mean 3.36, SD 1.34) followed by abdominal pain, tube dislodgment, weight loss and uncontrolled blood sugar. Nurses perceived that the incidences of complications are less likely to occur in the presence of evidence-based guidelines than absence (rho=0.73, df=251, p&lt;0.001). <h3>Conclusion</h3> Nurses show more concerns about the outcomes of enteral feeding instead of the preliminary assessment. Measuring gastric residual volume and confirming tube placement are still deficient and require further attention. Evidence-based practice is acknowledged by nurses where undertaking such protocols is emphasised. <h3>Competing interests</h3> None declared. <h3>References</h3> 1. <b>Adam S</b>, Batson S. A study of problems associated with the delivery of enteral feed in critically ill patients in five ICUs in the UK. <i>Intensive Care Med</i> 1997;<b>23:</b>261–6. 2. <b>Bourgault A</b>, Ipe L, Weaver J, <i>et al.</i> Development of evidence-based guidelines and critical care nurses9 knowledge of enteral feeding. <i>Critical Care Nurse</i> 2007;<b>27:</b>17–29. 3. <b>Fulbrook P</b>, Bongers A, Albarran JW. A European survey of enteral nutrition practices and procedures in adult intensive care units. <i>J Clin Nurs</i> 2007;<b>16:</b>2132–41. 4. <b>Mcclave S</b>, Martindale A, Vanek RG, <i>et al.</i> Guidelines for the provision and assessment of nutrition support therapy in the adult critically ill patient. <i>J Parenter Enteral Nutr</i> 2009;<b>33</b>:277–316. 5. <b>Persenius MW</b>, Larsson BW, Hall-lord M. Enteral nutrition in intensive care nurses9 perceptions and bedside observations. <i>Intensive Crit Care Nurs</i> 2006;<b>22:</b>82–94.
Tissue Engineering: Graphene-Based Patterning and Differentiation of C2C12 Myoblasts (Adv. Healthcare Mater. 7/2014)
Authors: Piyush Bajaj, Jose A. Rivera, Daniel Marchwiany, Vita Solovyeva, Rashid Bashir
Journal: Advanced Healthcare Materials (2014)

P. Bajaj, R. Bashir, and co-workers use graphene as a biomaterial for muscle tissue engineering. On page 995 enhanced differentiation and spontaneous alignment of myotubes is observed in accordance with the underlying lithographically patterned graphene substrate. In addition, graphene also leads to the functional maturity of C2C12 myotubes. Cover image created by Janet Sinn-Hanlon, DesignGroup@VetMed, University of Illinois-Urbana Champaign.
The Involvement of the Endocrine System in Regulating Cardiovascular Function: Emphasis on Vitamin D<sub>3</sub>*
Authors: RONALD E. WEISHAAR, ROBERT U. SIMPSON
Journal: Endocrine Reviews (1989)

DURING the last decade studies in a number of laboratories have provided evidence to suggest that the endocrine system plays an important role in regulating cardiovascular function. These studies have shown that the hormones insulin and thyroid hormone exert significant effects on key elements involved in regulating the activity of the cardiovascular system, including the distribution of myosin isozymes, the calcium pumping activity of the sarcoplasmic reticulum, and coronary flow. Recently, investigations have shown that the hormone, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], which is the active metabolite of vitamin D3, can also regulate cardiovascular function. The regulatory effects of 1,25(OH)2D3 include enhancement of cardiac and vascular muscle contractile function, modulation of blood pressure, and changes in myocardial collagen. The purpose of this review is to summarize current knowledge regarding the involvement of the endocrine system in regulating cardiovascular function, with emphasis on the recently described role of the vitamin D3 endocrine system in this regulation.
Bacterial Infection of Renal Calculus
Authors: Michael J. Droller
Journal: JAMA (1977)

SEVERAL conditions have been invoked to explain the persistence of urinary tract infection with a single organism: (1) infection stones, (2) chronic bacterial prostatitis, (3) abnormality of the urinary tract with patient susceptibility to infections.<sup>1</sup>The following case report illustrates the unexpected development of persistent urinary infection by the incorporation of bacteria into a preexisting renal calculus, and the use of bacterial localization studies to confirm this phenomenon. <h3>Report of a Case</h3> A 50-year-old man was first seen at the urology clinic in 1969 with gross, painless hematuria and intermittent, mild, leftsided flank pain of several months' duration. Thirty years earlier, he had undergone a left-sided pyelolithotomy. The following year he underwent a right-sided pyelolithotomy. He had been well urologically since that time. In 1968 he began to note occasional midepigastric pain. Results of a gastrointestinal work-up were normal, but kidneys, ureters, and urinary bladder (KUB) x-ray film showed
New Tool to Gauge Depression Remission Focuses on Good Feelings, Not Bad Ones
Authors: Rebecca Voelker
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Physician: The Life of Paul Beeson
Authors: Richard V. Lee
Journal: Annals of Internal Medicine (2002)

Medical Writings: Book Notes21 May 2002Physician: The Life of Paul BeesonRichard V. Lee, MDRichard V. Lee, MDThe State University of New York at Buffalo, Buffalo, New York.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-136-10-200205210-00025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Rapport R. 288 pages. Fort Lee, NJ: Barricade Books; 2001. $24.95. ISBN 1569802033. Order phone 201-944-7600.Field of medicine: Medical biography and history.Format: Hardcover book.Audience: Practicing physicians of all specialties; medical educators, medical students, and housestaff; and interested laypeople.Purpose: To describe the life of one of the most influential 20th-century physicians.Content: The author presents a highly readable story about Dr. Paul Beeson, who inspired generations of students and physicians as professor and chairman of medicine at Emory and Yale, Nuffield Professor of Medicine at Oxford, and a voice for the Physicians for Social Responsibility. Dr. Beeson's ... Author, Article, and Disclosure InformationAffiliations: The State University of New York at Buffalo, Buffalo, New York. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 21 May 2002Volume 136, Issue 10Page: 784KeywordsForecastingHistory of medicinePatientsPerceptionSoftware tools ePublished: 21 May 2002 Issue Published: 21 May 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Alternatives to Estrogen for Treatment of Hot Flashes
Authors: Jeffrey A. Tice, Deborah Grady
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
248 PROTECTIVE ROLE OF DIMETHYL-DIPHENYL- BICARBOXYLATE (DDB) ON APOPTOTIC REGULATORS IN HEPATIC ISCHEMIA REPERFUSION INJURY (IRI) ANIMAL MODEL
Authors: M. Naguib, A. Zaki, O. Heikal, L. Kassem, L. Mahran
Journal: Journal of Hepatology (2009)
Responding to Organ Failure in HIV-Infected Patients
Authors: Michelle E. Roland, Diane V. Havlir
Journal: New England Journal of Medicine (2003)

Until recently, patients infected with the human immunodeficiency virus (HIV) who had organ failure were not routinely evaluated for transplantation. The poor prognosis for persons with the acquired immunodeficiency syndrome (AIDS) early in the HIV epidemic led to their exclusion from organ-transplant waiting lists that were overflowing with patients who were expected to live much longer. The few patients with unrecognized HIV infection who received a transplant had a variable course, often characterized by rapid progression of HIV disease. Furthermore, there was an understandable fear of transmission of HIV to health care workers during invasive procedures.Even as the prognosis . . .
Epidemiology of Proliferative Diabetic Retinopathy
Authors: Ronald Klein, Barbara E K Klein, Scot E Moss
Journal: Diabetes Care (1992)

This review examines recent epidemiological data about the prevalence and incidence of and risk factors for proliferative diabetic retinopathy. In addition, the relation of proliferative retinopathy to other systemic complications associated with diabetes is reviewed.The data come mostly from the baseline and 4-yr follow-up examinations of a large population-based study, the WESDR, which involved 996 younger-onset insulin-dependent people whose diabetes was diagnosed at < 30 yr of age and 1370 older-onset people whose diabetes was diagnosed at > or = 30 yr of age, and who were taking or not taking insulin.The major finding is that proliferative retinopathy is a prevalent complication (23% in the WESDR younger-onset group, 10% in the WESDR older-onset group that takes insulin, and 3% in the group that does not take insulin). Hyperglycemia, longer duration of diabetes, and more severe retinopathy at baseline were associated with an increased 4-yr risk of developing proliferative retinopathy. However, higher blood pressure at baseline was associated only with the development of proliferative retinopathy in the younger-onset group. The presence of proliferative diabetic retinopathy was associated with an increased 4-yr risk of loss of vision, cardiovascular disease, diabetic nephropathy, and mortality. In the WESDR, a significant number of diabetic people with proliferative retinopathy at risk for vision loss were not under the care of an ophthalmologist or had not undergone panretinal photocoagulation.These data suggest that hyperglycemia and, possibly, high blood pressure are related to proliferative retinopathy. They also suggest that once proliferative diabetic retinopathy is detected, people should have a medical evaluation, because it is a strong indicator for the presence and development of systemic disease. These data also indicate that diabetic patients and their physicians should be aware of the need for routine ophthalmological examinations to detect and treat proliferative retinopathy.
Enzyme Tests for the Detection of Glucose
Authors: J. A. Hunt, C. H. Gray, D. E. Thorogood
Journal: BMJ (1956)

INTRACRANLAL ANEURYSM _MmJIuJ able for proximal ligature, trapping, or exclusion of the sac directly, a preliminary note on the method seems justifiable.Later complications arising directly from this material itself are unlikely, but only time will show whether, for instance, the parent artery rebels at encasement for part of its course in a rigid tube, though that would seem to be an unlikely danger.
Abstract 423: Suppression of endometrial cancer cell migration, invasion, and colony formation by the putative tumor suppressor gene <i>MIIP</i>
Authors: Yingmei Wang, Ping Ji, Da Yang, Limei Hu, David Cogdell, Russell Broaddus, Fengxia Xue, Wei Zhang
Journal: Cancer Research (2010)

Abstract Objective: Endometrial carcinoma (EC) is the leading cancer of the female genital tract in the United States and the fourth most common cancer among women after breast, lung, and colorectal cancer. Augmented cell motility, invasion, and proliferation are hallmarks of aggressive EC. We aim to determine whether the recently discovered migration and invasion inhibitory protein (MIIP) gene functions as an inhibitor for these hallmarks in endometrial cancer cells. Methods: We measured MIIP expression by Western blot and quantitative RT-PCR. The effect of MIIP on cell motility and invasion was measured by wound healing and Boyden Chamber transwell assay. The potential anti-tumor function of MIIP was measured by colony formation assay. Whole-genome transcriptome was determined in MIIP overexpressing cells and KEGG pathway analysis was done to determine the key pathways regulated by MIIP. Results: The levels of MIIP mRNA and protein expression were decreased in high-grade EC compared with normal EC tissues. MIIP protein is detectable at low level in the HEC1A cell line but undetectable in the AN3CA and HEC1B cell lines. Knockdown of MIIP expression with siRNA in HEC1A cells significantly increased cell migration when compared with control siRNA treated cells (71.17±3.82 vs. 30.12±1.94, P&amp;lt;0.01). Elevated expression of the MIIP significantly decreased cell migration in AN3CA and HEC1B cells compared with control empty vector-transfected cells (AN3CA: 26.67±1.86 vs. 69.83±2.93, P&amp;lt;0.01; HEC1B: 21.83±2.04 vs. 89.83±5.56, P&amp;lt;0.01). The invasion of the MIIP-knocked-down HEC1A cells was significantly increased compared with control (50.67±1.86 vs.5.83±1.47, P&amp;lt;0.01). Consistently, cell invasion was significantly decreased in MIIP overexpressed cells compared with control HEC1B cells (18.33±2.33 vs.43.17±4.07, P&amp;lt;0.01). Overexpression of MIIP in EC cell lines led to reduced levels of matrix metalloprotease 2 and 9. Further, transfection with the MIIP expression vector significantly reduced colony formation by 73.6% in HEC1A compared with empty vector-transfected cells (52.25±3.30 vs.13.75±2.87, P&amp;lt;0.01). Gene expression profiling of MIIP overexpressed AN3CA and HEC1B cells and their control cells followed by KEGG pathway analysis showed that MIIP expression regulates TP53 signaling, Jak-STAT signaling, and PI3K/Akt pathways. Conclusions: MIIP may function as a tumor suppressor gene for endometrial cancer and loss of MIIP expression may contribute to increased cell growth and migration/invasion activities in endometrial cancer cells. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 423.
Dynamic fluctuations in blood of thrombin/antithrombin III complex (TAT)
Authors: Katsumi Deguchi, Mituo Noguchi, Eiichi Yuwasaki, Takurou Endou, Akira Deguchi, Hideo Wada, Seikou Murashima, Masakatu Nishikawa, Shigeru Shirakawa, Kuniyoshi Tanaka, Minoru Kusagawa
Journal: American Journal of Hematology (1991)

The dynamic fluctuation of thrombin-antithrombin III complex (TAT) was studied in blood obtained during the daytime (at 9 AM, noon, 3 PM), during extracorporeal circulation and during the course of disseminated intravascular coagulation (DIC), to certify whether the level of TAT in blood can reflect the generation of thrombin. In 10 healthy male volunteers, the mean values of TAT (micrograms/liter) were 1.74 (+/- 1.36) at 9 AM, 1.22 (+/- 0.47) at noon, and 1.25 (+/- 0.68) at 3 PM. TAT did not show a daytime fluctuation, unlike fibrinolytic factors. The mean values of TAT in 38 hemodialyzed patients were 4.83 (+/- 2.8) before the initiation, 6.59 (+/- 4.39) in the first hour, and 13.42 (+/- 10.96) at the end of a dialysis session. In 20 patients undergoing open heart surgery, the mean value of TAT was increased during cardiopulmonary bypass (CPB) and decreased with time after the end of surgery. The fibrinopeptide A (FPA) value was increased with TAT during CPB but achieved a maximum level immediately after heparin neutralization by protamine. In 20 patients with DIC, the values of TAT varied from 5.8 to 297 micrograms/liter in the blood at the onset of DIC. In seven of eight patients treated with low-molecular-weight heparin (LMW-H), the values of TAT and FPA were lower 24 hr after LMW-H than before the treatment. These results suggest that the level of TAT in blood reflected the formation of thrombin and could serve as a sensitive parameter of activated coagulation in circulating blood.
Statistical computing in the United States.
Authors: R C Milton
Journal: Environmental Health Perspectives (1979)

Recent history and developments related to the increase in statistical computing activities in the United States and by U.S. participants in international efforts are reviewed, with emphasis on important events, organizations, references, and products which contribute to informed selection and use of statistical programs. Three features matrices for major statistical packages are included as potential aids to Japanese statisticians in assessing the utility of these packages in biostatistical applications.
Pregnancy after Breast Cancer in Young Patients Does Not Worsen the Outcome of Breast Cancer.
Authors: O. Cordoba, M. Sabadell, I. Rubio, T. Cortadellas, J. Xercavins
Journal: Cancer Research (2009)

Abstract Background: Pregnancy after breast cancer may worsen the outcome of breast cancer due to associated hormonal changes, especially among young patients. However, prior studies have failed to detect this effect, which may be explained by the selection of patients of older age and those that gave birth to term. The aim of this study is to assess the effects of pregnancy on the outcome of breast cancer in young patients.Patients: One hundred twenty three young patients (≤35 years) with invasive breast cancer or ductal carcinoma in situ treated consecutively at our hospital between 1995 and 2005. Pregnancy was discouraged during the first two years, but not specific recommendation was given thereafter.Methods: We compared the prognostic factors, treatment with adjuvant chemotherapy treatment and follow-up between patients with pregnancy after breast cancer (P) and those who have not had subsequent pregnancy (NP).Results: There were 20 patients that get pregnant (16%). Of them, eight (40%) decided to interrupt pregnancy, and twelve (60%) gave birth to the term. The average time between diagnosis of cancer and pregnancy was four years. Several prognostic factors, such as age at diagnostic (median age 31 years old in both groups), histological type (CDI in P81% NP83.2%), clinical stage(P: 0 9.5%, I 38.1%, IIA 42.9%, IIIA 9.58%; NP: 0 7.9%, I 23.8%, IIA 32.7%, IIB 16.8%, IIIA 8.9%, IIIB 5.9%, IV 1%), positive axillary lymph nodes (P: 44.4% NP: 51.7%), histological high grade (P: 52.9% NP: 50.6%) and use of chemotherapy (P:76.2 NP: 89.2%) were similar among pregnant and non-pregnant women with differences who was not stadistical significance. However, use of hormonal treatment were more frequent in patients without later gestation (P: 33.% NP 68% p=0.003). Ductal Carcinoma in situ is more frequent among patients wit pregnancy but the difference is not statistical significant (P: 14% NP 4% p=0.10). Patients with pregnancy had better disease-free interval at 5 years (P95% vs NP62% p = 0.003) and overall 5 years survival(100% vs. 82% p = 0.008).Conclusions: A significant proportion of patients diagnosed of breast cancer at young age get pregnant, many of them unwillingly. Our study shows that pregnancy does not seem to worsen outcome. Patients should be counselling do not discontinuing her pregnancy. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 2062.
Stornoway sausages—the surgical solution at sea
Authors: Elizabeth A McClure
Journal: BMJ (2007)

<h3>ABSTRACT</h3> <h3>Background</h3> Perforations of the pedicle wall during cannulation can occur with experienced surgeons. Direct endoscopic visualization has not been used to inspect pedicles previously due to bone bleeding obscuring the camera visualization. The hypothesis of this study was that endoscopic visualization of pedicle wall integrity was technically feasible and would enable identification of clinically significant pedicle breaches. <h3>Methods</h3> A live porcine model was used. Eight lumbar pedicles were cannulated. Clinically significant breaches were created. An endoscope was introduced and was used to inspect the pedicles. <h3>Results</h3> All lumbar pedicles were endoscopically visible at a systolic pressure of 100 mm Hg. Clinically relevant anatomic structures and iatrogenic pathology, such as medial, lateral, and anterior breaches, were identified. There were no untoward events resulting from endoscopic inspection of the pedicle endosteal canal. <h3>Conclusions</h3> Endoscopic inspection of lumbar pedicles was safe and effective. The findings on endoscopic inspection corresponded with the ball-tip probe palpation techniques. Additional techniques, such as selection between 2 tracts, was possible with the endoscopic technique.