tbuckley/cabot-search huggingface dataset:
P562 ASSESSMENT OF MALIGNANT POTENTIAL OF HEPATIC HYPOVASCULAR NODULES USING COMBINATION IMAGING STUDIES IN PATIENTS WITH CHRONIC LIVER DISEASE
Authors: Y. Tanaka, T. Nakazawa, T. Minamino, J. Takada, Y. Okuwaki, M. Watanabe, H. Hidaka, S. Akitaka, M. Keiji, K. Wasaburo
Journal: Journal of Hepatology (2014)
Epsilon-aminocaproic acid therapy for dental extractions in haemophiliacs.
Authors: M. W. Cooksey, C. B. Perry, A. B. Raper
Journal: BMJ (1966)

MEDITALJSHoUR 1633 3.In pregnant patients with severe anaemia (whether irondeficiency or megaloblastic in type) who are near term.The potential hazards of post-partum haemor- rhage or an operative procedure exists, as in every parturient.In the haemolytic type of anaemia due to sickle-cell disease and malaria seen in Western Nigeria Fullerton and Turner (1962) have also shown the value of exchange transfusion. SummaryA study is presented of the indications and effects of exchange transfusion in gynaecology and obstetrics.The investigation includes a detailed study of 50 consecutive patients who on admission had a haemoglobin level below 4.4 g./ 100 ml. (30%).These patients were assigned by the method of random sampling to receive either an exchange transfusion or a slow packed-cell transfusion.In no case was the cardiac function, clotting mechanism, or electrolyte balance in any way impaired, nor was there any evidence of citrate toxicity.Subsequent exchange transfusion of a further 31 patients lends support to our finding that exchange transfusion is a safe procedure, the indications for which have been discussed.Thus exchange transfusion is of great value to the woman in anaemic cardiac failure, and to the severely anaemic patient who is pregnant, is approaching delivery, or requires an urgent gynae- cological or obstetrical operation.We are grateful to Professor J. Lawson, of University College Hospital, Ibadan, for valuable suggestions in the initial stages of this study, and to Dr. J. Powell, of the University of Natal, for
Effect of Ingestion of Meat on Plasma Cholesterol of Vegetarians
Authors: Frank M. Sacks, Allan Donner, William P. Castelli, James Gronemeyer, Peter Pletka, Harry S. Margolius, Lewis Landsberg, Edward H. Kass
Journal: JAMA (1981)

In a controlled trial, 21 strict vegetarians were studied prospectively for eight weeks: a two-week control period of the usual vegetarian diet was followed by four weeks, during which 250 g of beef was added isocalorically to the daily vegetarian diet and then by two weeks of the control diet. Plasma high-density lipoprotein-cholesterol did not change during the study, whereas plasma total cholesterol rose significantly by 19% at the end of the meat-eating period. Systolic blood pressure (BP) increased significantly during the meat eating by 3% over control values, whereas diastolic BP showed no major changes. Plasma renin activity, prostaglandin A and E levels, and urinary kallikrein, norepinephrine, and epinephrine excretions were within normal limits and did not change notably throughout the trial. The study suggests an adverse effect of consumption of beef on plasma lipid and BP levels.
Smallness Is a State of Mind
Authors: Samuel M. Chen
Journal: JAMA (1982)

The curriculum for the second year of medical school included a mandatory course in the history of medicine. This was taught by a small distinguished-looking professor with white hair, thick glasses, a PhD, and a soft monotone that, coupled with the tedium of the subject matter, virtually guaranteed somnolence. I often wonder if he was really more excited about the subject than he let on, or whether this was one of those exercises to be endured by teacher and student alike. Thinking I had better use for my time, I frequently absented myself, believing that in a class of more than 80 students I wouldn't be missed. (I failed to notice the record taker, so unobtrusive was she.)  As fate would have it, I succumbed to a temptation that presented itself in the form of the New Physician , the journal of the Student American Medical Association. It featured a column
DEVICE TO HOLD SUSPENSION TACKLE ON THE JAMB OF A DOOR
Authors: Wilton H. Robinson
Journal: JAMA (1924)

While suspension is relatively little used now in the application of plaster casts, there occasionally turns up a case in which it is desired to suspend the patient by the Sayre headpiece. In such a contingency we are sometimes faced with the problem of where to attach the apparatus overhead.  The device illustrated is simple and inexpensive, and answers the purpose well.  It is made from a pair of heavy ice tongs that have a chain handle. The handle is removed and two short pieces of steel substituted, a hole being provided in the lower end of each to receive a hook or piece of rope to attach the head apparatus. The ends of the tongs are blunted, and to each is brazed a heavy piece of iron or steel, 3 or 4 inches long and about an inch wide. It is best to attach a spring between the arms
The Language of Case Histories
Authors: Barry J. Wu
Journal: Annals of Internal Medicine (1998)

Letters15 May 1998The Language of Case HistoriesBarry J. Wu, MDBarry J. Wu, MDHospital of St. Raphael; New Haven, CT 06511Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-10-199805150-00030 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:It has been nearly 30 years since Weed introduced the problem-oriented medical record [1]. His system revolutionized the manner in which patient care was described in the medical record. It later resulted in the development of the progress note formatted by the acronym SOAP (S = subjective, O = objective, A = assessment, and P = plan). These terms have evolved and have often led to the misunderstanding of clinical information as either subjective or objective [2]. Subjective information has come to be viewed as “existing only in the mind,” whereas objective information is seen to reflect “actual ...References1. Weed LL. Medical records that guide and teach. N Engl J Med. 1968; 278:652-7. Google Scholar2. Donnelly WJ. Brauner DJ. Why SOAP is bad for the medical record. Arch Intern Med. 1992; 152:481-4. Google Scholar3. American heritage Dictionary. 2d College Edition. Boston: Houghton Mifflin; 1985. 1997; 127:1045-8. Google Scholar4. Donnelly WJ. The language of medical case histories. Ann Intern Med. 1997; 127:1045-8. Google Scholar Author, Article, and Disclosure InformationAuthors: Barry J. Wu, MDAffiliations: Hospital of St. Raphael; New Haven, CT 06511 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 May 1998Volume 128, Issue 10Page: 877KeywordsElectronic medical recordsHealth careHealth care providersInternetPatientsSoaps ePublished: 15 August 2000 Issue Published: 15 May 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Ventricular Septal Defects in Adults
Authors: Naser M. Ammash, Carole A. Warnes
Journal: Annals of Internal Medicine (2001)

Because congenital ventricular septal defects are of different sizes and locations, their clinical presentation, natural history, and treatment vary greatly. This review discusses the different types of ventricular septal defects commonly seen in adults in the authors' experience and in published literature. Ventricular septal defects are either isolated small defects or larger defects associated with pulmonary stenosis, pulmonary hypertension, or aortic regurgitation. These associations play an important role in the pathophysiologic consequences of the defect, its long-term complications, and treatment options. Knowledge of the different clinical presentations in adulthood and the specific features pertinent to these defects will help in the assessment and the care of adult patients with one of the most common congenital cardiac malformations.
The Effect of Priscoline on the Clearance of Radiosodium from Muscle and Skin of Man in Normal and Diseased Limbs
Authors: JACK FREUND, LAWRENCE H. WISHAM, ROSALYN S. YALOW
Journal: Circulation (1953)

The radiosodium clearance technic was used to measure the effect of Priscoline given intraarterially on the effective blood flow in muscle and skin of normal subjects and patients with peripheral vascular disease. The only clinically significant increase in the clearance rate of radiosodium (Na 24 ) occurred in the skin; the clearance rate in muscle showed small increases which were constantly present but not considered to be clinically significant.
Acute GVHD is a strong predictor of full donor CD3+ T cell chimerism after reduced intensity conditioning allogeneic stem cell transplantation
Authors: Jean El‐Cheikh, Alberto Vazquez, Roberto Crocchiolo, Sabine Furst, Boris Calmels, Luca Castagna, Claude Lemarie, Angela Granata, Patrick Ladaique, Claire Oudin, Catherine Faucher, Christian Chabannon, Didier Blaise
Journal: American Journal of Hematology (2012)

The monitoring of chimerism is a standard procedure to assess engraftment and achievement of full donor lymphoid cells after reduced intensity conditioning (RIC) stem cell transplantation (Allo-SCT). However, there is no consensus on when and how often to monitor post-transplant chimerism. We retrospectively analyzed our experience regarding the impact of acute graft versus host disease (GVHD) for the prediction of allograft chimerism. One-hundred-and-fifteen patients transplanted between 2001 and 2010 were identified. This group included 57 females and 58 males with a median age of 50 years (range: 26-68). Patients evaluated in this study were adult patients with hematologic malignancies, who received transplants from an HLA-matched sibling donor or matched unrelated donor (MUD) at allele level so-called 10/10, and received the RIC regimen including fludarabine/busulfan and anti-thymoglobulin (ATG). Mixed T-cell chimerism was defined as between 5 and 94% recipient cells, and full chimerism was defined as the presence of more than 95% donor T-cell chimerism (TCC). Full donor TCC was achieved in 93 patients (81%) at a median of 77 days (range: 30-120) post-transplant. The cumulative incidence of Grade 2-4 GVHD in our population was 25% (95% CI 17-34). The analysis of the population of patients with acute GVHD grade ≥2 showed that at day 120 after Allo-SCT they all had a total full donor TCC. On the other hand, 78 (68%) patients without acute GVHD grade ≥2 presented with mixed chimerism (p = 0.002) on day 120 post-transplant. Interestingly, patients who received ATG 5 mg/kg obtained a higher probability of complete chimerism compared with those receiving 2.5 mg/kg (p = 0.03). In conclusion, our study demonstrates that acute GVHD was predictive of full donor TCC after RIC Allo-SCT. Therefore, our data may challenge the concept of the frequent or close monitoring of donor chimerism in some patients with ongoing acute GVHD. However, chimerism testing could represent an attractive modality for minimal residual disease detection or for impeding relapse warranting further prospective studies.
Intrathoracic Splenosis
Authors: ISIS W. GAYED, SHEHAB M. ELSHAZLY
Journal: Clinical Nuclear Medicine (2000)

The authors examined a 33-year-old man who was involved in a motor vehicle accident approximately 10 years previously and had sustained significant injuries, including splenic rupture, left diaphragmatic rupture, hemopneumothorax, and left lung collapse. Immediately, the patient was operated on: His spleen was removed and the left diaphragm was repaired. Ten years later, the patient was examined because of a new nonhealing ulcer overlying a right tibial fracture. A Tc-99m–labeled WBC scan was performed to rule out osteomyelitis. Although he had no chest- or abdominal-related complaints, the labeled WBC scan showed multiple foci of intense tracer uptake in the left hemithorax. These foci represent left intrathoracic splenosis after left diaphragmatic rupture. Splenosis is usually seen in the abdomen and pelvis and is unusual in the chest.
ABC of sexual health: Sexual variations
Authors: W P de Silva
Journal: BMJ (1999)

Cytokines can be produced within the nervous system by various cell types, including astrocytes, which secrete them in response to pathological processes such as viral infections. Astrocytes are known to play an important role in the homeostasis of the nervous system, in particular, by contributing to the regulation of local energy metabolism. We report that tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 alpha (IL-1 alpha) markedly stimulate glucose uptake and phosphorylation in primary cultures of neonatal murine astrocytes, as determined with [3H]-2-deoxyglucose ([3H]2DG). This effect is both concentration dependent, with observed EC50 values of 8 ng/ml for TNF-alpha and 30 pg/ml for IL-1 alpha, and time dependent, with a maximal response observed 24 hr after cytokine application. The effects of TNF-alpha and IL-1 alpha on glucose uptake and phosphorylation appear to be mediated by the phospholipase A2 signal transduction pathway. Evidence in support of this includes (i) inhibition by mepacrine, a phospholipase A2 inhibitor, of [3H]2DG uptake evoked by TNF-alpha and IL-1 alpha, and (ii) stimulation of [3H]arachidonic acid release by TNF-alpha and IL-1 alpha. Protein kinase C activation does not appear to be involved as the specific protein kinase C inhibitor Ro 31-7549 does not abolish TNF-alpha- or IL-1 alpha-induced increase in [3H]2DG uptake and phosphorylation. The additional glucose imported by astrocytes on exposure to TNF-alpha and IL-1 alpha is neither stored as glycogen nor released as glycolytically derived lactate, suggesting that it is processed through the tricarboxylic acid cycle or pentose phosphate pathway. These results demonstrate that TNF-alpha and IL-1 alpha can fundamentally perturb the energy metabolism of astrocytes, possibly impairing their ability to provide adequate energy substrates for neurons.
Age and death in breast carcinoma.
Authors: R Burkitt
Journal: BMJ (1979)

had no hyperacidic peptic ulceration.As regards the second patient, simply oversewing perforations leads to further surgery in 20% of cases in five years.This is extremely rarely required within two months.2The occurrence and timing of recurrence of ulceration in both cases strongly suggests that cimetidine treatment or its withdrawal was implicated.When H2-blockade of acid-secreting cells is withdrawn, it is more likely to lead to excessive sensitivity to normal stimuli than to hyperplasia.
Wanted: A New Type of Consumer Advocate for Drugs
Authors: Louis Lasagna
Journal: New England Journal of Medicine (1978)

The United States government, in its attempt to appear even-handed and open to various points of view, has increasingly dictated that the makeup of advisory committees reflect not only expertise in the area of concern to the committee, but also the "interests" of certain segments of the public.In the Food and Drug Administration, this development has resulted in the appointment of so-called "consumer representatives" to some advisory committees. How these persons are chosen, or whom they represent, is not clear. But it is evident that some highly influential consumerist advocates speak for themselves rather than as a result of . . .
The Influence of Atrial Pressure on Cardiac Performance Following Myocardial Infarction Complicated by Shock
Authors: R. D. BRADLEY, B. S. JENKINS, M. A. BRANTHWAITE
Journal: Circulation (1970)

Performance curves for both sides of the heart were derived in six patients with acute myocardial infarction complicated by cardiogenic shock. Stroke index and right and left ventricular stroke work index were related to mean atrial pressures which were lowered by venesection. Values for cardiac index, stroke index, and stroke work index were all low, and little change occurred with alterations in atrial pressures. The relationship of right and left atrial pressures to the genesis of pulmonary edema is discussed, and the effects of isoproterenol (isoprenaline) are described.
Integrated regulation of pressure and flow in the coronary microcirculation
Authors: J. M. Muller, M. J. Davis, W. M. Chilian
Journal: Cardiovascular Research (1996)

There are many mechanisms that contribute to the regulation of coronary blood flow including vasodilatory metabolites, myogenic regulation, flow- or shear stress-mediated vasodilation, and neurohumoral influences. It is interesting to note that coronary arterioles of varying sizes appear to possess different sensitivities to these regulatory factors, but each appears to dominate the control of a particular segment of the microvasculature. For example, during metabolic hyperemia the smallest arterioles seem to be most sensitive to the effects of metabolites, but metabolic and myogenic mechanisms that dictate the tone of upstream microvessels likely act in concert to facilitate the overall adjustments in coronary vasomotor tone. Neurohumoral mechanisms seem to modulate the robustness of these intrinisic adjustments, perhaps by restraining the extent of vasodilation. The purpose of this review is to discuss these many regulatory mechanisms and also present a framework by which the vasoactive reactions elicited by these different mechanisms are integrated into coordinated responses of the entire coronary vascular network.
Correlation between statin therapy before percutaneous coronary intervention, periprocedural creatine kinase-MB release, and mortality at follow-up
Authors: Annapoorna S. Kini, Paul Lee, Cristina A. Mitre, Ajay Agarwal, Shazia Mukaddam, Michael C. Kim, Samin K. Sharma
Journal: Journal of the American College of Cardiology (2003)
The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues
Authors: Claudia Waskow, Kang Liu, Guillaume Darrasse-Jèze, Pierre Guermonprez, Florent Ginhoux, Miriam Merad, Tamara Shengelia, Kaihui Yao, Michel Nussenzweig
Journal: Nature Immunology (2008)
Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer
Authors: Bin-Bing S. Zhou, Michael Peyton, Biao He, Changnian Liu, Luc Girard, Eian Caudler, Yvonne Lo, Frederic Baribaud, Iwao Mikami, Noemi Reguart, Gengjie Yang, Yanlong Li, Wenqing Yao, Kris Vaddi, Adi F. Gazdar, Steven M. Friedman, David M. Jablons, Robert C. Newton, Jordan S. Fridman, John D. Minna, Peggy A. Scherle
Journal: Cancer Cell (2006)
Incidence of Sexually Transmitted Infections After Human Papillomavirus Vaccination Among Adolescent Females
Authors: Anupam B. Jena, Dana P. Goldman, Seth A. Seabury
Journal: JAMA Internal Medicine (2015)

Human papillomavirus (HPV) vaccination rates among US females remain low, in part because of concerns that HPV vaccination may promote unsafe sexual activity by lowering perceived risks of acquiring a sexually transmitted infection (STI).To study whether HPV vaccination of females is associated with increases in STI rates.Using a large, longitudinal insurance database of females aged 12 to 18 years insured from January 1, 2005, through December 31, 2010, in the United States, we examined whether HPV vaccination was associated with an increase in incident STIs among females who were vaccinated compared with those who were not. We defined STIs as one or more medical claims for any of the following infections in a given quarter: chlamydia, gonorrhea, herpes, human immunodeficiency virus or AIDS, or syphilis. We used difference-in-difference analysis to compare changes in STI rates among HPV-vaccinated females before and after vaccination (index quarter) to changes among age-matched nonvaccinated females before and after the index quarter. We analyzed whether effects varied according to age and prior contraceptive medication use.Rates of STIs.The rates of STIs in the year before vaccination were higher among HPV-vaccinated females (94 of 21 610, 4.3 per 1000) compared with age-matched nonvaccinated females (522 of 186 501, 2.8 per 1000) (adjusted odds ratio, 1.37; 95% CI, 1.09-1.71; P = .007). The rates of STIs increased for the vaccinated (147 of 21 610, 6.8 per 1000) and nonvaccinated (781 of 186 501, 4.2 per 1000) groups in the year after vaccination (adjusted odds ratio, 1.50; 95% CI, 1.25-1.79; P < .001). The difference-in-difference odds ratio was 1.05 (95% CI, 0.80-1.38; P = .74), implying that HPV vaccination was not associated with an increase in STIs relative to growth among nonvaccinated females. Similar associations held among subgroups aged 12 through 14 years and aged 15 through 18 years and among females with contraceptive use in the index quarter.Human papillomavirus vaccination was not associated with increases in STIs in a large cohort of females, suggesting that vaccination is unlikely to promote unsafe sexual activity.
Medical Practice in Modern England
Authors: P. Norton
Journal: BMJ (1967)

BEDICALJOURNALone cannot help feeling that a crisis could easily have been avoided if there had been greater awareness at high level of the possible effects on the public health service of the imbalance created by recent awards in other sections of the profession.One is forced to conclude that the Government will attempt to avoid its commitments in regard to the public health service, and it may well be that the present uncertainty will, to a limited extent, effect a " shake out " into general practice.For many of us, however, such a course would be an unacceptable and unpalatable admission that the not inconsiderable personal sacrifice involved in obtaining the statutory qualification (D.P.H.) had been a pointless
Paraplegia Due to Paget's Disease (Osteitis Deformans)
Authors: R. G. Robinson
Journal: BMJ (1953)

Osteitis deformans, or Paget's disease, may affect any part of the skeleton in those of older years.While involvement of the spinal column is frequent, it is unusual for compression of the spinal cord to be produced.It is probable that this complication is com- moner than the literature would indicate, as it occurs in an age group in which accurate assessments of the nervous system are rarely made.Two cases are described and their relationship to the usual pattern of the disease discussed.Case 1 A woman aged 64 was admitted to Dunedin Hospital on January 21, 1952.Three and a half years ago she had begun to notice a nagging pain in the small of her back.This was followed by increasing pain in the hips and knees.About a year ago she had had burning pains in both legs, and her feet had felt numb and lifeless.Walking had become difficult, and eventually she had had to use two sticks.For a year her balance had been bad and she had I am grateful to Dr. John Willis, of Palmerston North, for referring Case 1 and to Dr.