tbuckley/cabot-search huggingface dataset:
Bone Scintigraphy in Blastomycotic Osteomyelitis
Authors: BRUCE L. DANIEL, JEFFREY P. CRABBE, LYNDON GRITTERS, BRAHM SHAPIRO
Journal: Clinical Nuclear Medicine (1993)

DANIEL, BRUCE L. M. D.; CRABBE, JEFFREY P. M. D.; GRITTERS, LYNDON M. D.; SHAPIRO, BRAHM M. B., CH. B., PH. D. Author Information
Treatment of the Housebound Housewife Syndrome
Authors: T. Kraft
Journal: Psychotherapy and Psychosomatics (1967)

Research Articles| February 12 2010 Treatment of the Housebound Housewife Syndrome Subject Area: Psychiatry and Psychology T. Kraft T. Kraft St. Clement's Hospital, London Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1967) 15 (6): 446–453. https://doi.org/10.1159/000285908 Article history Published Online: February 12 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation T. Kraft; Treatment of the Housebound Housewife Syndrome. Psychother Psychosom 1 June 1967; 15 (6): 446–453. https://doi.org/10.1159/000285908 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1967Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Traveling Medical Societies
Authors: Ure Ost
Journal: JAMA (1961)

<h3>To the Editor:—</h3> It is to be wondered if the traveling medical societies have not outlived their usefulness. Perhaps in the past they may have had some educational purpose when there were not as many instruments of communication, such as the present-day multiplicity of teaching clinics and community and state medical meetings, as well as the existing plethora of journals, scientific movies, television series, and the like. The unfortunate secretary of the group must find a suitable hospital, medical school, or research institute with recognized eminence, one whose staff members are known for their participation in some popular kind of research or a "new" clinical approach, and who are willing to have visitors. Once the secretary has made suitable arrangements, he must convince the membership of the desirability of "his" program. After much persuasion, 30 physicians indicate that they will make the trip. Actually, various emergencies will arise, and no
The Use and Abuse of Endoscopic Retrograde Cholangiopancreatography
Authors: Robert M. Craig
Journal: JAMA (1983)

With the proliferation of indications for endoscopic retrograde cholangiopancreatography (ERCP), it is appropriate to analyze some of its costs and benefits. The cost of the procedure ranges between $800 and $1,000, including the fees of the endoscopist and radiologist and the institutional charges for the endoscopy suite and radiological facilities. The ERCP procedure may be used to provide preoperative evaluation of chronic, unremitting pain attributable to chronic pancreatitis and the study of pancreatic pseudocysts. We believe that this procedure should be done to assist the surgeon in tailoring his surgery to the ductal pathological findings.  When carcinoma of the pancreas is suspected, ERCP may also be used. However, the treatment of curable lesions has remained disappointingly low, since the disease is so far advanced at the time of diagnosis. Nonetheless, the ampullary malignant neoplasm encountered at surgery for obstructive jaundice is curable and is diagnosable with ERCP or percutaneous cholangiography
Prophylaxis against hepatitis B recurrence following liver transplantation using combination lamivudine and hepatitis B immune globulin
Authors: Jay S. Markowitz, Paul Martin, Andrew J. Conrad, James F. Markmann, Philip Seu, Hasan Yersiz, John A. Goss, Peter Schmidt, Anita Pakrasi, Lucy Artinian, Natalie G. Murray, David K. Imagawa, Curtis Holt, Leonard I. Goldstein, Risë Stribling, Ronald W. Busuttil
Journal: Hepatology (1998)

Patients undergoing liver transplantation for hepatitis B-related liver disease are prone to recurrence. The mainstay of prophylaxis has been passive immunotherapy with hepatitis B immune globulin (HBIG). Antiviral therapy with lamivudine has proven effective in lowering hepatitis B virus (HBV) DNA and improving histology in patients with hepatitis B infection; its role in prophylaxis against hepatitis B recurrence following liver transplantation is under investigation. Viral breakthrough and resistance, however, are a significant problem with monotherapy with either HBIG or lamivudine. The efficacy of combination lamivudine/HBIG prophylaxis has not been reported. Fourteen patients underwent transplantation for decompensated liver disease owing to hepatitis B. Lamivudine (150 mg p.o./d) was begun before transplantation in 10 patients, including 4 who were HBV DNA-positive. In addition, 1 patient was HBV DNA-positive when transplanted. HBIG was given perioperatively and continued thereafter; treatment with lamivudine was maintained or initiated at the time of transplantation and continued indefinitely. The median follow-up was 387 days. Actuarial 1-year patient and graft survival was 93% (1 patient died of unrelated causes). At a median interval of 28 days following lamivudine treatment, all 5 HBV DNA-positive patients cleared HBV DNA from the serum; 1 went on to clear hepatitis B surface antigen (HBsAg), before transplantation, at day 148 of lamivudine treatment. By the highly sensitive polymerase chain reaction (PCR), at a median of 346 days (range, 130-525 days) following transplantation, all 13 surviving patients had no detectable serum HBV DNA. Lamivudine suppresses HBV replication in patients awaiting liver transplantation. At a median follow-up of 1.1 years, combination prophylaxis with lamivudine and HBIG prevented hepatitis B recurrence following liver transplantation.
Gastrointestinal Motility and Diabetes Mellitus
Authors: W.S. REVENO
Journal: Annals of Internal Medicine (1983)

Letters and Corrections1 July 1983Gastrointestinal Motility and Diabetes MellitusW.S. REVENO, M.D.W.S. REVENO, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-99-1-128_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The general tone of the discussion by Feldman and Schiller (1) on gastrointestinal motility and diabetes mellitus appears devoted to non-insulin-dependent diabetes with no mention made as to whether the group studied included both insulin-dependent and non-insulin-dependent diabetic patients. Also, diarrhea lactase deficiency as another cause deserves consideration....Reference1. FELDMANSCHILLER ML. Disorders of gastrointestinal motility associated with diabetes mellitus. Ann Intern Med. 1983;99:378-84. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: 16500 N. Park Drive, Southfield, MI 48075 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1983Volume 99, Issue 1Page: 128-128KeywordsDiabetes mellitusDiarrheaGastrointestinal motility disordersInsulinType 2 diabetes Issue Published: 1 July 1983 PDF DownloadLoading ...
Regulation of Matrix Metalloproteinase Expression in Human Vascular Smooth Muscle Cells by T Lymphocytes
Authors: Uwe Schönbeck, François Mach, Galina K. Sukhova, Curran Murphy, Jean-Yves Bonnefoy, Rosalind P. Fabunmi, Peter Libby
Journal: Circulation Research (1997)

Abstract Physical disruption of an atheromatous lesion often underlies acute coronary syndromes. Matrix-degrading enzymes, eg, matrix metalloproteinases (MMPs), may cause loss in mechanical integrity of plaque tissue that favors rupture. T lymphocytes accumulate at sites where atheromata rupture, but the mechanisms by which these immune cells may contribute to plaque destabilization are unknown. This study tested the hypothesis that the T-lymphocyte surface molecule CD40 ligand (CD40L), recently localized in atherosclerotic plaques, regulates the expression of MMPs in human vascular smooth muscle cells (SMCs), the most numerous cell type in arteries. We report here that stimulated human T lymphocytes induced the expression of the matrix-degrading enzymes, ie, interstitial collagenase (MMP-1), stromelysin (MMP-3), gelatinase B (MMP-9), and activated gelatinase A (MMP-2), in human vascular SMCs by cell contact via CD40 ligation, as demonstrated by Western blot analysis, zymography, and antibody neutralization. Recombinant human CD40L (rCD40L) induced de novo synthesis of MMP-1, MMP-3, and MMP-9 on vascular SMCs and stimulated the expression of these enzymes to a greater extent than did maximally effective concentrations of tumor necrosis factor-α or interleukin-1β, established agonists of MMP expression. Interferon gamma, another T-lymphocyte–derived cytokine, inhibited the induction of MMPs by rCD40L. Immunohistochemical analysis of human coronary atheromata colocalized MMP-1 and MMP-3 with CD40-positive SMCs. These results demonstrated that CD40 ligand, expressed on T lymphocytes, promoted the expression of matrix-degrading enzymes in vascular SMCs and thus established a new pathway of immune-modulated destabilization in human atheromata.
The CD4/CD8 Ratio in Vitreous Fluid Is of High Diagnostic Value in Sarcoidosis
Authors: Kentaro Kojima, Kazuichi Maruyama, Tohru Inaba, Kenji Nagata, Toru Yasuhara, Kazuhito Yoneda, Sunao Sugita, Manabu Mochizuki, Shigeru Kinoshita
Journal: Ophthalmology (2012)
The Ajuba LIM Domain Protein Is a Corepressor for SNAG Domain–Mediated Repression and Participates in Nucleocytoplasmic Shuttling
Authors: Kasirajan Ayyanathan, Hongzhuang Peng, Zhaoyuan Hou, William J. Fredericks, Rakesh K. Goyal, Ellen M. Langer, Gregory D. Longmore, Frank J. Rauscher
Journal: Cancer Research (2007)

Abstract The SNAG repression domain is comprised of a highly conserved 21–amino acid sequence, is named for its presence in the Snail/growth factor independence-1 class of zinc finger transcription factors, and is present in a variety of proto-oncogenic transcription factors and developmental regulators. The prototype SNAG domain containing oncogene, growth factor independence-1, is responsible for the development of T cell thymomas. The SNAIL proteins also encode the SNAG domain and play key roles in epithelial mesenchymal differentiation events during development and metastasis. Significantly, these oncogenic functions require a functional SNAG domain. The molecular mechanisms of SNAG domain–mediated transcriptional repression are largely unknown. Using a yeast two-hybrid strategy, we identified Ajuba, a multiple LIM domain protein that can function as a corepressor for the SNAG domain. Ajuba interacts with the SNAG domain in vitro and in vivo, colocalizes with it, and enhances SNAG-mediated transcriptional repression. Ajuba shuttles between the cytoplasm and the nucleus and may form a novel intracellular signaling system. Using an integrated reporter gene combined with chromatin immunoprecipitation, we observed rapid, SNAG-dependent assembly of a multiprotein complex that included Ajuba, SNAG, and histone modifications consistent with the repressed state. Thus, SNAG domain proteins may bind Ajuba, trapping it in the nucleus where it functions as an adapter or molecular scaffold for the assembly of macromolecular repression complexes at target promoters. [Cancer Res 2007;67(19):9097–106]
CASE OF STAB WOUND OF THE HEART, OPERATION AND RECOVERY
Authors: SAMUEL BRADBURY
Journal: JAMA (1913)

An Italian woman, aged 44, was brought to the Pennsylvania hospital at noon on April 18, 1909. She had been stabbed in the chest about ten minutes previously. Examined immediately on admission. She was unconscious, very pale, the skin was moist and cold, there was slight dyspnea and no pulse could be felt at the wrist. A wound 1.5 cm. long was present over the second left intercostal space about 5 cm. from the sternal edge. The heat sounds could be heard faintly, were rapid and slightly irregular, but no adventitious sound was heard. The breasts were lactating and full. The outline of cardiac dulness was not determined. Ether, 25 minims, then 1/20 grain of strychnin were given hypodermatically at once, and slightly irregular. The diagnosis was wound of the heart. Operation was started at 12:50 p. m. A curved incision was made about the inner border of the breast from the second to the fifth rib, and skin, breast and muscles reflected outward.
Risk of gastrointestinal effects with COX-2 inhibitors and NSAIDs: What does evidence from randomised trials show about celecoxib?
Authors: Jonathan L Underhill
Journal: BMJ (2005)

Rationing in response to NHS deficits: rural patients are likely to be affected most See News, p 1426Editor-News that pressing financial problems have caused NHS trusts in Suffolk to set new "thresholds" to treatments such as joint replacements reinforces concerns raised by a recent BMA survey of medical directors of trusts in which over a third of respondents anticipated reductions of key services in response to funding shortfalls. 1 2 What has hitherto escaped comment is how cuts in services are far more likely to be felt in some parts of the country than others.Deficits in the NHS are invariably presented as a problem of financial mismanagement, but the pattern of deficits shows that the current resource allocation model discriminates against particular communities.According to the recently published accounts for 2004-5, 3 89 out of 303 (30%) English primary care trusts ended the year in deficit.The table shows how 301 of these trusts are distributed accorded to fifths of deprivation and rurality.Primary care trusts serving populations that are in both the most rural and the least deprived fifth were most likely to be in financial difficulties.Seventeen of the 25 (68%) in this category were in deficit.These trusts received the lowest funding allocation per head (£995).By contrast, only 3% (one of 34) of the primary care trusts serving populations that are in both the most urban and the most deprived fifths failed to break even in 2004-5.These trusts received the highest funding allocations per head (£1405).This shows that poor financial management can at best only partly explain why some trusts are in deficit.The pattern of deficits implies that NHS funding provides insufficient resources for rural areas, for comparatively affluent areas, and, most particularly, for areas that are both rural and affluent.The risk is that such measures will result in NHS services being subject to a new postcode lottery, in which rural residents are more likely to lose out.
STUDIES ON THE BACTERIOPHAGE OF D'HÉRELLE
Authors: Jacques J. Bronfenbrenner, Charles Korb
Journal: The Journal of Experimental Medicine (1925)

When bacteriophage is precipitated by alcohol at room temperature its activity rapidly and progressively decreases until it is totally destroyed, between 6 and 24 hours after exposure. If the percipitation is carried out at 7 degrees C. the destruction of lytic activity is considerably slower; measurable traces may be detected even after 4 weeks exposure to alcohol. Although the major portion of the lytic activity is found in the precipitate, the supernatant alcohol carries a measurable amount of lytic principle which remains active for several days. In all cases the residual lytic activity was found to be transmissible in series. In no instance were we able to observe the non-transmissible action ascribed by d'sHérelle to the enzyme. The persistence of traces of active principle after many weeks of exposure to alcohol at low temperature is not found to be due to the existence in the original filtrate of a fraction relatively resistant to the effect of alcohol. The inactivation of bacteriophage by alcohol seems, therefore, analogous to the alcoholic inactivation of certain enzymes and toxins.
Unexpected Death Due to Intracranial Tumors
Authors: Orville T. Bailey
Journal: New England Journal of Medicine (1949)

UNEXPECTED DEATH DUE TO INTRACRANIAL TUMORSThe symptoms caused by intracranial tumors extend over months or years in the great majority of cases. For this reason, brain tumors would not be expected to appear in the records of the medical examiner except as incidental findings in patients dying of other causes. A survey of records, however, shows that intracranial tumors are found in a considerable number of cases as the principal cause of death. This note is concerned with some of the mechanisms by which unexpected deaths may be brought about by these lesions.Gliomas that infiltrate and replace cerebral . . .
Eye-Care Delivery for People With Diabetes: An unmet need
Authors: Ronald Klein
Journal: Diabetes Care (1994)

Diabetic retinopathy is a leading cause of blindness in the U. S. (1). However, this need not be the case. A recently completed clinical trial sponsored by the National Eye Institute, the Early Treatment Diabetic Retinopathy Study, demonstrated that early detection and treatment of proliferative retinopathy and clinically significant macular edema with laser photocoagulation could prevent vision loss (2,3). Ferris (4) estimated that timely treatment of proliferative retinopathy with panretinal photocoagulation should reduce serious vision loss by 95%. However, data from a number of studies suggest that a significant number of Americans with diabetes may not be receiving recommended eye examinations for the detection of retinopathy (5–7). Delivery of such care has been shown to prev nt vision loss and be cost-effective (8,9).
Effect of vagotomy on the gastric secretory response to intraduodenal osmotic agents in man.
Authors: A S Ward
Journal: Gut (1976)

The effect of intraduodenal infusion of hypertonic saline and glucose on pentagastrin-stimulated gastric secretion was investigated in 35 normal subjects, 32 duodenal ulcer patients and 32 patients after truncal vagotomy and pyloroplasty. A significant gastric inhibitory response occurred after 0.51 M saline and 1-03 M glucose in the normal subjects and duodenal ulcer patients but after vagotomy there was no inhibition. This finding suggests that the inhibitory effect of these agents depends, at least in part, on a vagal reflex in man. The response to very high glucose concentrations persisted after vagotomy and it seems likely that a humoral mechanism may be involved in this situation.
Eotaxin and CCR3 are up‐regulated in exacerbations of chronic bronchitis
Authors: V. Bocchino, G. Bertorelli, C.P. Bertrand, P.D. Ponath, W. Newman, C. Franco, A. Marruchella, S. Merlini, M. Del Donno, X. Zhuo, D. Olivieri
Journal: Allergy (2002)

Eosinophils and T lymphocytes represent constant features in the airways of subjects with exacerbated chronic bronchitis. Eotaxin is the most potent and selective eosinophil chemoattractant which can also attracts lymphocytes. The aim of the study was to evaluate the expression of eotaxin and its receptor, CCR3, in bronchial airways during exacerbation of chronic bronchitis.By immunohistochemistry we studied eotaxin and CCR3 expression in the lamina propria of 14 subjects with acute exacerbation of chronic bronchitis. 20 asthmatics, and 8 healthy subjects. We determined the cell types expressing the CCR3 receptor by colocalization experiments. We finally studied the relationship between eotaxin and CCR3 and eosinophils and T lymphocytes.The number of eotaxin+ and CCR3+ cells was significantly higher in exacerbated chronic bronchitis (P<0.003 and P<0.002) and asthma (P<0.002 and P<0.0001) when compared to healthy subjects. CCR3 was mainly expressed by eosinophils and to a lesser extent by CD4+ and CD8+ lymphocytes. In exacerbated chronic bronchitis the number of CCR3+ cells was strongly correlated to the number of eosinophils (P<0.0002. r=0.85) and to the number of CD4+ lymphocytes (P<0.05, r=0.57).Our study suggests that eotaxin and CCR3 are up-regulated and could be involved in the eosinophil and CD4+ lymphocyte recruitment into the airways which occur during acute exacerbations of chronic bronchitis.
Factors associated with massive fibrosis in silicosis.
Authors: T P Ng, S L Chan
Journal: Thorax (1991)

Data on 1432 patients with silicosis on a register in Hong Kong were analysed to examine the association of massive fibrosis with possible predisposing factors. Detailed occupational and clinical histories, clinical records, radiographic readings according to the International Standard Classification of Radiographs of Pneumoconioses, and environmental dust measurements from hygiene surveys were used to obtain information for several variables--namely, age at first exposure, relative dust exposure level, duration of exposure, smoking, previous recorded history of tuberculosis, and background profusion of small opacities. The most significant risk factors associated with massive fibrosis were high relative dust exposure level, a history of tuberculosis, and increased background profusion of small opacities.