tbuckley/cabot-search huggingface dataset:
Pulmonary fibrosis associated with TINF2 gene mutation: is somatic reversion required?
Authors: Yoshinori Tanino, Hiroki Yamaguchi, Atsuro Fukuhara, Mitsuru Munakata
Journal: European Respiratory Journal (2014)

To verify this hypothesis, one could sequence the TINF2 gene of the patient with DNA from other tissue, a buccal swab and/or a lung sample, where the mutation would probably appear as ''really'' heterozygous.In addition, high throughput sequencing (with next-generation sequencing) of TINF2 in DNA from the patient's blood should provide precise data on the mutation frequency.However, one cannot definitely exclude the fact that TINF2 mutations could lead to far more heterogeneous clinical phenotypes than previously described.
The effects of premedication drugs on the lower oesophageal high pressure zone and reflux status of rhesus monkeys and man.
Authors: A W Hall, A R Moossa, J Clark, G R Cooley, D B Skinner
Journal: Gut (1975)

Thirty-five human volunteers and eight Rhesus monkeys were studied with standard gastrooesophageal manometric techniqes and their reflux status was evaluated witha pH probe placed in the lower oesophagus. morphine sulphate, pethidine hydrochloride, or idazepam was given intravenously until drowsiness was induced. The manometric and pH studies were repeated. All three drugs decreased the lower oesophageal high pressure zone and increased the probability of relux in both monkeys and man. Thes findings are relevant in the preparation of patients for surgery since gastrooesophageal reflux and pulmonary aspiration may be a problen in the pre-and postoperative phases.
Treating rheumatoid arthritis to target: the patient version of the international recommendations
Authors: M P T de Wit, J S Smolen, L Gossec, D M F M van der Heijde
Journal: Annals of the Rheumatic Diseases (2011)

To transcribe the treat-to-target (T2T) recommendations into a version that can be easily understood by patients. A core group of physicians and patients involved in the elaboration of the T2T recommendations produced a draft version of the T2T recommendations in lay language. This version was discussed, changed and reworded during a 1-day meeting with nine patients with rheumatoid arthritis (RA) from nine different European countries. Finally, the level of agreement with the translation and with the content of the recommendations was assessed by the patient participants. The project resulted in a patient version of the T2T recommendations. The level of agreement with the translation and the content was high. The group discussion revealed a number of potential barriers for the implementation of the recommendations in clinical practice, such as inequalities in arthritis healthcare provision across Europe. An accurate version of the T2T recommendations that can be easily understood by patients is available and can improve the shared decision process in the management of RA.
The Therapeutic Effect of Anti-HER2/neu Antibody Depends on Both Innate and Adaptive Immunity
Authors: SaeGwang Park, Zhujun Jiang, Eric D. Mortenson, Liufu Deng, Olga Radkevich-Brown, Xuanming Yang, Husain Sattar, Yang Wang, Nicholas K. Brown, Mark Greene, Yang Liu, Jie Tang, Shengdian Wang, Yang-Xin Fu
Journal: Cancer Cell (2010)
The influence of residual coronary stenosis on size of infarction after reperfusion in a canine preparation.
Authors: S B Schmidt, P J Varghese, S Bloom, J M Yackee, A M Ross
Journal: Circulation (1986)

The effect of a residual coronary artery stenosis on size of myocardial infarction was studied in an open-chest canine preparation of coronary occlusion and reperfusion. Eighteen male mongrel dogs (16 to 26 kg) underwent left thoracotomy under general anesthesia; the circumflex artery was instrumented with a hydraulic cuff occluder, a screw clamp, and an electromagnetic flow probe. Animals were randomized to one of three groups: group I (n = 6) had a 6 hr circumflex occlusion, group II (n = 6) had a 2 hr occlusion followed by 4 hr of partial reperfusion through a residual stenosis adjusted to approximately 30% of baseline flow, and group III (n = 6) had full reperfusion for 4 hr after a 2 hr occlusion. Zones of risk, infarction, and no reflow were defined by staining with Evans blue, triphenyl tetrazolium chloride, and fluorescein, respectively. At 6 hr the hearts were excised and areas of risk, infarction, no reflow, and hemorrhage were determined by planimetry of serial transverse heart slices (5 mm thick). Infarction as a percent of the risk area was 96 +/- 1% in group I, 90 +/- 2% in group II, and 79 +/- 4% in group III (p less than .001), and the differences between each of the groups were significant. Gross hemorrhage was seen in none of the six dogs in group I, two of the six in group II, and five of the six in group III, but did not affect infarct size. We conclude that residual stenoses may exert a deleterious effect on the outcome of coronary reperfusion.(ABSTRACT TRUNCATED AT 250 WORDS)
In vivo magnetic resonance spectroscopy measurement of deoxymyoglobin during exercise in patients with heart failure. Demonstration of abnormal muscle metabolism despite adequate oxygenation.
Authors: D M Mancini, J R Wilson, L Bolinger, H Li, K Kendrick, B Chance, J S Leigh
Journal: Circulation (1994)

BACKGROUND Skeletal muscle metabolic abnormalities have been described in patients with heart failure that are independent of total limb perfusion, histochemical changes, and muscle mass. However, these skeletal muscle metabolic abnormalities may result from tissue hypoxia caused by maldistribution of flow. Myoglobin is an O2 binding protein that can indirectly assess tissue hypoxia. METHODS AND RESULTS In vivo measurement of deoxymyoglobin was performed by use of proton (1H) magnetic resonance spectroscopy in 16 heart failure (HF) (left ventricular ejection fraction = 20 +/- 6%; VO2 = 14.5 +/- 5.1 mL/kg per minute) and 7 healthy (Nl) subjects. Simultaneous phosphorus (31P) magnetic resonance spectroscopy and near-infrared spectroscopy also were obtained to examine muscle metabolism and oxygenation. Supine calf plantarflexion was performed every 4 seconds. Incremental steady-state work was performed. A second exercise protocol studied rapid incremental (RAMP) exercise with plantarflexion every 2 seconds. Arterial occlusion at end exercise provided physiological calibration for myoglobin and hemoglobin signals. With steady-state exercise, the work slope, ie, inorganic phosphorus to phosphocreatine ratios versus work, was significantly greater in patients with heart failure (Nl: 0.18 +/- 0.08; HF: 0.40 +/- 0.32 W-1; P &lt; .05). Intracellular pH was reduced significantly at end exercise in patients but not healthy subjects. Despite these metabolic abnormalities, muscle oxygenation derived from 760- to 850-nm absorption was comparable in both groups throughout exercise. The relation of inorganic phosphorus/phosphocreatine (P1/PCr) ratio and muscle oxygenation was shifted upward in patients with heart failure such that at the same muscle oxygenation, Pi/PCr ratio in these patients was increased. No deoxymyoglobin signals were observed at rest. At maximal exercise, 4 of the healthy subjects and 3 of the patients exhibited deoxymyoglobin (P = NS). With RAMP exercise, the work slope was again significantly greater in patients with heart failure (Nl: 0.21 +/- 0.10; HF: 0.57 +/- 0.32 W-1; P &lt; .05). Intracellular pH again was significantly decreased at end exercise in patients but not healthy subjects. Five of the healthy subjects and 3 of the heart failure patients had deoxymyoglobin signal (P = NS). With arterial occlusion, deoxymyoglobin was seen in all subjects. CONCLUSION Abnormal skeletal muscle metabolism in patients with heart failure usually occurs in the absence of myoglobin deoxygenation, suggesting that the abnormalities are not a result of cellular hypoxia during exercise with minimal cardiovascular stress.
Inadvertent intravenous administration of trivalent influenza vaccine. Confusion of vaccine cartridge with heparin flush cartridge
Authors: L. P. Van Voris
Journal: JAMA (1981)

INFLUENZA vaccine is administered annually to millions of persons in order to prevent influenza virus infection.<sup>1</sup>The Public Health Service recommends administration of trivalent influenza vaccine (AH1N1, AH3N2, and B) to high-risk patients in the late summer and fall months.<sup>2</sup>The package inserts that accompany influenza vaccine and the manual<i>Facts and Comparisons</i>(St Louis, Facts and Comparisons Inc, 1980) advise that the vaccine should not be administered intravenously (IV). However, in the discussion of adverse reactions, the possible consequences of IV injection of the influenza vaccine are not mentioned. We report here the misidentification of a trivalent influenza vaccine cartridge for a heparin flush cartridge and subsequent IV administration of trivalent influenza vaccine to at least one patient. <h3>Report of a Case</h3> On Oct 22, 1979, influenza vaccine was ordered for three patients in one hospital ward. Three cartridge-needle units (TUBEX) (0.5 mL) of trivalent (split virus)
Organ Transplantation
Authors: Alden M. Doyle, Robert I. Lechler, Laurence A. Turka
Journal: Journal of the American Society of Nephrology (2004)

The ancient dream of successful organ transplantation was finally realized 50 yr ago, on December 23, 1954, at the Peter Bent Brigham Hospital in Boston. Over the subsequent half century, the separate disciplines of clinical transplantation and transplant immunology have made remarkable progress.
Autologous Stem-Cell Transplantation in Patients With HIV-Related Lymphoma
Authors: Pascual Balsalobre, José L. Díez-Martín, Alessandro Re, Mariagrazia Michieli, José M. Ribera, Carmen Canals, Anne Rosselet, Eulogio Conde, Rosario Varela, Kate Cwynarski, Ian Gabriel, Philippe Genet, Gaelle Guillerm, Bernardino Allione, Augustin Ferrant, Pierre Biron, Ildefonso Espigado, David Serrano, Anna Sureda
Journal: Journal of Clinical Oncology (2009)

Peripheral-blood autologous stem-cell transplantation (ASCT) in patients with HIV-related lymphoma (HIV-Ly) has been reported as a safe and useful procedure. Herein we report the European Group for Blood and Marrow Transplantation experience on patients with HIV-Ly undergoing ASCT.This was a retrospective, multicentric, registry-based analysis.Since 1999, 68 patients from 20 institutions (median age, 41 years; range, 29 to 62 years) were included, diagnosed with non-Hodgkin's lymphoma (NHL; n = 50) or Hodgkin's lymphoma (n = 18). At the time of ASCT, 16 patients were in first complete remission (CR1); 44 patients were in CR more than 1, partial remission, or chemotherapy-sensitive relapse (chemo-S); and eight patients had chemotherapy-resistant disease. The median number of CD34(+) cells infused was 4.5 x 10(6)/kg (range, 1.6 to 21.2 x 10(6)/kg). Median time to neutrophil and platelet engraftment were 11 days (range, 8 to 36 days) and 14 days (range, 6 to 455 days), respectively, with a cumulative incidence (CI) at 1 year of 95.6% and 87%, respectively. CI of nonrelapse mortality (NRM) was 7.5% at 12 months after ASCT, mainly because of bacterial infections. CI of relapse was 30.4% at 24 months, statistically related with not being in CR at ASCT (relative risk [RR] = 3.6), NHL histology other than diffuse large B-cell lymphoma (RR = 3.4), and use of more than two previous treatment lines (RR = 3). At a median follow-up of 32 months (range, 2 to 81 months), progression-free survival (PFS) was 56%. Patients not in CR or with refractory disease at ASCT had poorer PFS (RR = 2.4 and 4.8, respectively).Similarly to HIV-negative patients with lymphoma, ASCT is a useful treatment for patients with HIV-Ly and is associated with low NRM, mainly when performed in early stages and chemo-S disease.
Does Government Regulation Enhance Quality of Cardiovascular Procedures?
Authors: Robert H. Jones
Journal: Circulation (2006)

ardiovascular specialists encumbered with excessive intrusion into the patient-doctor relationship will likely agree with the conclusion of DiSesa et al 1 that the coronary artery bypass grafting (CABG) mortality rate was not different between the 26 states with certificate-ofneed (CON) programs and the 24 states without CON regulation.Data from the Society of Thoracic Surgeons' (STS) National Cardiac Database (NCD) on 595 200 patients undergoing isolated CABG procedures for 4 consecutive years ending in 2003 used the STS NCD risk-stratification algorithm to predict an equivalent occurrence of death after CABG during hospitalization or within 30 days for both the 280 512 patients treated in non-CON states and the 314 710 patients treated CON states (Table 5 in DiSesa et al 1 ).The observed perioperative CABG mortality rate was 2.52% for CON states and 2.62% for states without CON regulations (odds ratio [OR]ϭ0.97,Pϭ0.32).
High-dose topotecan with granulocyte-colony stimulating factor in fluoropyrimidine-refractory colorectal cancer: A phase II and pharmacodynamic study
Authors: E.K. Rowinsky, S.D. Baker, K. Burks, S. O’Reilly, R.C. Donehower, L.B. Grochow
Journal: Annals of Oncology (1998)
Effect of Weight Loss With Lifestyle Intervention on Risk of Diabetes
Authors: Richard F. Hamman, Rena R. Wing, Sharon L. Edelstein, John M. Lachin, George A. Bray, Linda Delahanty, Mary Hoskin, Andrea M. Kriska, Elizabeth J. Mayer-Davis, Xavier Pi-Sunyer, Judith Regensteiner, Beth Venditti, Judith Wylie-Rosett
Journal: Diabetes Care (2006)

Diabetes Prevention Program (DPP) participants randomized to the intensive lifestyle intervention (ILS) had significantly reduced risk of diabetes compared with placebo participants. We explored the contribution of changes in weight, diet, and physical activity on the risk of developing diabetes among ILS participants. For this study, we analyzed one arm of a randomized trial using Cox proportional hazards regression over 3.2 years of follow-up. A total of 1,079 participants were aged 25-84 years (mean 50.6 years, BMI 33.9 kg/m(2)). Weight loss was the dominant predictor of reduced diabetes incidence (hazard ratio per 5-kg weight loss 0.42 [95% CI 0.35-0.51]; P < 0.0001). For every kilogram of weight loss, there was a 16% reduction in risk, adjusted for changes in diet and activity. Lower percent of calories from fat and increased physical activity predicted weight loss. Increased physical activity was important to help sustain weight loss. Among 495 participants not meeting the weight loss goal at year 1, those who achieved the physical activity goal had 44% lower diabetes incidence. Interventions to reduce diabetes risk should primarily target weight reduction.
Cardiac troponin testing in idiopathic inflammatory myopathies and systemic sclerosis-spectrum disorders: biomarkers to distinguish between primary cardiac involvement and low-grade skeletal muscle disease activity
Authors: Michael Hughes, James B Lilleker, Ariane L Herrick, Hector Chinoy
Journal: Annals of the Rheumatic Diseases (2015)

Primary cardiac involvement, an under-recognised manifestation of the idiopathic inflammatory myopathies (IIM) and systemic sclerosis (SSc)-spectrum disorders, is associated with significant mortality. Within these two conditions, traditional skeletal muscle enzyme testing may not effectively distinguish between skeletal and cardiac muscle involvement, especially in patients with subclinical cardiac disease. Accurate biomarkers are thus required to screen for cardiac disease, to better inform both therapeutic decision-making and treatment response. The widespread uptake of cardiac troponin testing has revolutionised the management of acute coronary syndromes. While cardiac troponin I (cTnI) appears specific to the myocardium, cardiac troponin T (cTnT) is also expressed by skeletal muscle, including regenerating skeletal muscle tissue. There is increasing interest about the role of cardiac troponins as a putative biomarker of primary cardiac involvement in IIM and SSc-spectrum disorders. Herewith we discuss subclinical cardiac disease in IIM and SSc-spectrum disorders, the respective roles of cTnI and cTnT testing, and the re-expression of cTnT within regenerating skeletal muscle tissue. There remains wide variation in access to cardiac troponin testing nationally and internationally. We propose two pragmatic clinical pathways using cardiac troponins, preferably measuring concomitant cTnT followed by confirmatory (cardiac) cTnI to screen patients for subclinical cardiac disease and/or low-grade skeletal muscle disease activity, and also an agenda for future research.
Allelic association of gene markers on chromosomes 5q and 11q with atopy and bronchial hyperresponsiveness.
Authors: I J Doull, S Lawrence, M Watson, T Begishvili, R W Beasley, F Lampe, T Holgate, N E Morton
Journal: American Journal of Respiratory and Critical Care Medicine (1996)

To investigate genetic factors in asthma and atopy, we sought allelic associations for 12 markers near candidate loci for serum total, immunoglobulin E (IgE), and bronchial hyperresponsiveness (BHR) to inhaled histamine in 131 families comprising 685 individuals, selected randomly without regard to atopy or asthma. Nonparametric linkage and association analyses were performed with the Nonparametric Analysis of Lineage and Association (NOPAR) program, and parametric analyses were performed with the Complex Inheritance with Diathesis and Severity (COMDS) program on an ordered polychotomy of ranked scores. On chromosome 11q, allele 168 at the D11S527 locus was significantly associated with BHR (p<0.0003) but not with log IgE. At the D11S534 locus, allele 235 was significantly associated with log IgE (p = 0.007) but not with BHR. Both D11S527 and D11S534 were too distant from the gene encoding the high-affinity IgE receptor FcepsilonRIbeta to account for the association. At the interleukin-9 (IL-9) locus, the 118 allele showed significant association with serum total IgE (p<0.003) but not with histamine BHR. Parametric tests are more conservative, perhaps because they demand consistency with mendelian inheritance and tight linkage. These findings provide support for the view that both chromosomes 5 and 11 may contain genes relevant to asthma and atopy, a possible candidate being the interleukin-4 (IL-4) gene cluster. Because these associations are extremes in a large number of tests, they require confirmation in other samples.
Efficacy of BCG vaccine against leprosy and tuberculosis in northern Malawi
Authors: J.M. Ponnighaus, E. Msosa, P.J.K. Gruer, N.G. Liomba, P.E.M. Fine, J.A.C. Sterne, R.J. Wilson, L. Bliss, P.A. Jenkins, S.B. Lucas
Journal: The Lancet (1992)
Induction of Claudin-4 by Nonsteroidal Anti-inflammatory Drugs and Its Contribution to Their Chemopreventive Effect
Authors: Shinji Mima, Shinji Tsutsumi, Hironori Ushijima, Miho Takeda, Ikue Fukuda, Kazumi Yokomizo, Keitarou Suzuki, Kuniaki Sano, Tohru Nakanishi, Wataru Tomisato, Tomofusa Tsuchiya, Tohru Mizushima
Journal: Cancer Research (2005)

Abstract Nonsteroidal anti-inflammatory drugs (NSAID) have shown chemopreventive effects in both preclinical and clinical studies; however, the precise molecular mechanism governing this response remains unclear. We used DNA microarray techniques to search for genes whose expression is induced by the NSAID indomethacin in human gastric carcinoma (AGS) cells. Among identified genes, we focused on those related to tight junction function (claudin-4, claudin-1, and occludin), particularly claudin-4. Induction of claudin-4 by indomethacin was confirmed at both mRNA and protein levels. NSAIDs, other than indomethacin (diclofenac and celecoxib), also induced claudin-4. All of the tested NSAIDs increased the intracellular Ca2+ concentration. Other drugs that increased the intracellular Ca2+ concentration (thapsigargin and ionomycin) also induced claudin-4. Furthermore, an intracellular Ca2+ chelator [1,2-bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid] inhibited the indomethacin-dependent induction of claudin-4. These results strongly suggest that induction of claudin-4 by indomethacin is mediated through an increase in the intracellular Ca2+ concentration. Overexpression of claudin-4 in AGS cells did not affect cell growth or the induction of apoptosis by indomethacin. On the other hand, addition of indomethacin or overexpression of claudin-4 inhibited cell migration. Colony formation in soft agar was also inhibited. Suppression of claudin-4 expression by small interfering RNA restored the migration activity of AGS cells in the presence of indomethacin. Based on these results, we consider that the induction of claudin-4 and other tight junction–related genes by NSAIDs may be involved in the chemopreventive effect of NSAIDs through the suppression of anchorage-independent growth and cell migration.
Diets for Insulin Pump and Multiple Daily Injection Therapy
Authors: Maryanne Grinvalsky, David M Nathan
Journal: Diabetes Care (1983)

The role of diet in achieving and maintaining normalized blood glucose control in type I diabetic patients using insulin pumps or multiple daily injection (MDI) regimens is not well defined. We describe herein dietary guidelines that have proved effective in the management of such patients over 3 yr. The guidelines stress the importance of a careful dietary history, the regularity and consistency of diet during the preliminary adjustment period, the establishment of a variable insulin dosage schedule based on meal size and content as well as blood glucose, the appropriate treatment for hypoglycemia, and dietary adjustments for exercise. While insulin pump and MDI therapy may ultimately provide increased flexibility in certain aspects of dietary therapy, the diet must be carefully controlled if these innovative modes of insulin delivery are to succeed.
Proteoglycan expression patterns in human hair follicle
Authors: S. Malgouries, S. Thibaut, B.A. Bernard
Journal: British Journal of Dermatology (2007)

Proteoglycans (PGs) are known to play key roles in many cellular signalling pathways involved in hair follicle biology. Although some PG core proteins have previously been described in adult human hair follicles, their glycosaminoglycan (GAG) moieties have been less studied.To add knowledge about PG core protein and GAG distributions in human anagen hair follicle and, for selected follicles, during catagen.We used immunohistochemistry and immunohistofluorescence to revisit the expression pattern of GAG chains and core proteins in human hair follicle. The studied epitopes included CD44v3, syndecan-1, perlecan, versican, aggrecan, biglycan, heparan sulphate (HS), chondroitin sulphate (CS), dermatan sulphate (DS) and keratan sulphate (KS).The membrane PGs syndecan-1 and CD44v3 were respectively detected in the epithelial part of whole hair and in the outer root sheath basal layer. The dermal part of the hair follicle contained high amounts of extracellular PGs such as perlecan, versican, aggrecan, biglycan and their saccharidic moieties, namely HS, CS, DS and KS. We also observed a variable distribution of these components along the hair follicle. Especially, we noted a PG impoverishment at the very bottom of the anagen bulb. Moreover, while type D chondroitin expression remained unaffected, 4C3-CS and PG4-CS/DS epitopes respectively decreased in the dermal papilla and the connective tissue sheath, at the onset of catagen.GAG and PG expression along the human anagen hair follicle was characterized by (i) discontinuities mainly affecting the basement membrane and (ii) disappearance of some epitopes at catagen onset. These results are discussed in term of functionalities in nutrient diffusion, cell proliferation and differentiation, and hair protection.