Aortic Stenosis: Physiological, Pathological, and Clinical Concepts
Authors: EUGENE BRAUNWALD
Journal: Annals of Internal Medicine (1963)

Clinical Staff Conference1 March 1963Aortic Stenosis: Physiological, Pathological, and Clinical ConceptsCombined Clinical Staff Conference at the National Institutes of HealthEUGENE BRAUNWALD, M.D., F.A.C.P., WILLIAM C. ROBERTS, M.D., ALLAN GOLDBLATT, M.D., MAURICE M. AYGEN, M.D., S. DAVID ROCKOFF, M.D., JOSEPH W. GILBERT, M.D.EUGENE BRAUNWALD, M.D., F.A.C.P., WILLIAM C. ROBERTS, M.D., ALLAN GOLDBLATT, M.D., MAURICE M. AYGEN, M.D., S. DAVID ROCKOFF, M.D., JOSEPH W. GILBERT, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-3-494 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDr. Eugene Braunwald: The region of the aortic valve is the last point passed by the blood in its course through the heart and lungs. As long as the functions of the left ventricle and left atrium are well maintained, obstruction to left ventricular outflow may be extremely severe without the clinical manifestations of heart failure, which tend to occur earlier in the course of the disease, when the obstruction exists at a point upstream to the aortic valve. As a consequence, the relationships between the physiological and clinical abnormalities that exist in patients with obstruction to left ventricular outflow...References1. MENCARELLI L: Stenosi sopravalvolare aortica ad anello. Arch. Ital. Anat. Path. 1: 829, 1930. Google Scholar2. DENIEVERHEUGT JJAP: Supravalvular aortic stenosis. Circulation 18: 902, 1958. CrossrefMedlineGoogle Scholar3. MORROWWALDHAUSENPETERSBLOODWELLBRAUNWALD AGJARLRDE: Supravalvular aortic stenosis. Clinical, hemodynamic and pathologic observations. Circulation 20: 1003, 1959. CrossrefMedlineGoogle Scholar4. PEROU ML: Congenital supravalvular aortic stenosis. Arch. Path. 71: 453, 1961. 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MORROWBROCKENBROUGH AGEC: Surgical treatment of idiopathic hypertrophic sub-aortic stenosis. Ann. Surg. 154: 181, 1961. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Bethesda, MarylandThis is an edited transcription of a combined clinical staff conference at the Clinical Center, Bethesda, Maryland, by the National Heart Institute, National Institutes of Health, Public Health Service, Department of Health, Education, and Welfare.Requests for reprints should be addressed to Eugene Braunwald, M.D., Cardiology Branch, National Heart Institute, Bethesda 14, Maryland. 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MASON, M.D., EUGENE BRAUNWALD, M.D.Aortic Baroreceptor Activity during Permanent Distension of the Receptor AreaClinical PhonocardiographyPercentage of Left Ventricular Stroke Work LossThe Mechanism of the Intraventricular Pressure Gradient in Idiopathic Hypertrophic Subaortic StenosisVentricular repolarization in congenital aortic stenosisManagement of congenital aortic stenosis in children and young adultsRecognition of Left Ventricular Outflow ObstructionGenetische Untersuchungen bei supravalvul�ren AortenstenosenDiagnostic Value of the First and Second Derivatives of the Arterial Pressure Pulse in Aortic Valve Disease and in Hypertrophic Subaortic StenosisThe Circulatory Response of Patients with Idiopathic Hypertrophic Subaortic Stenosis to Nitroglycerin and to the Valsalva ManeuverEffects of Beta Adrenergic Blockade on the Circulation, with Particular Reference to Observations in Patients with Hypertrophic Subaortic Stenosis 1 March 1963Volume 58, Issue 3Page: 494-522KeywordsAortic valveHeartIsoproterenolLeft atriumLeft ventricleLungsMedical servicesPrevention, policy, and public healthStenosisSyncope ePublished: 1 December 2008 Issue Published: 1 March 1963 PDF downloadLoading ...