tbuckley/cabot-search huggingface dataset:
An 8-factor prognostic model predicted early death in patients with traumatic bleeding
Authors: John Kepros
Journal: Annals of Internal Medicine (2012)

ACP Journal Club20 November 2012An 8-factor prognostic model predicted early death in patients with traumatic bleedingJohn Kepros, MDJohn Kepros, MDMichigan State University/Sparrow Hospital, Lansing, Michigan, USA (J.K.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-157-10-201211200-02013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationPerel P, Prieto-Merino D, Shakur H, et al. Predicting early death in patients with traumatic bleeding: development and validation of prognostic model. BMJ. 2012;345:e5166. https://pubmed.ncbi.nlm.nih.gov/22896030Clinical Impact RatingsEmergency Med: Critical Care: References1 Rehn M, Perel P, Blackhall K, Lossius HM. Prognostic models for the early care of trauma patients: a systematic review. Scand J Trauma Resusc Emerg Med. 2011;19:17. [PMID: 21418599] Google Scholar2 Rogers FB, Osler T, Krasne M, et al. Has TRISS become an anachronism? A comparison of mortality between the National Trauma Data Bank and Major Trauma Outcome Study databases. J Trauma Acute Care Surg. 2012;73:326-31. [PMID: 22846935] Google Scholar3 Fueglistaler P, Amsler F, Schüepp M, et al. Prognostic value of Sequential Organ Failure Assessment and Simplified Acute Physiology II Score compared with trauma scores in the outcome of multiple-trauma patients. Am J Surg. 2010;200:204-14. [PMID: 20227058] Google Scholar4 Sasser SM, Hunt RC, Sullivent EE, et al; National Expert Panel on Field Triage, Centers for Disease Control and Prevention (CDC). Guidelines for field triage of injured patients. Recommendations of the National Expert Panel on Field Triage. MMWR Recomm Rep. 2009;58:1-35. [PMID: 19165138] Google Scholar Author, Article, and Disclosure InformationAffiliations: Michigan State University/Sparrow Hospital, Lansing, Michigan, USA (J.K.)This article was published at Annals.org on 6 November 2012. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 20 November 2012Volume 157, Issue 10Page: JC5-13KeywordsHemorrhageHospitalizationsHygienePatientsRespiratory rateResuscitationSystolic pressureTriage ePublished: 20 November 2012 Issue Published: 20 November 2012 CopyrightCopyright © 2012 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
THE FAILURE OF A BACTERIAL VACCINE AS A PROPHYLACTIC AGAINST INFLUENZA
Authors: G. W. McCOY
Journal: JAMA (1918)

The necessity for accurate, controlled observations on preparations that are used as prophylactic agents for influenza is our reason for presenting the subjoined data.  The bacterial vaccine used in the present investigation was kindly furnished by Dr. F. O. Tonney, chief of the laboratory of the Chicago Health Department. While we are not intimately acquainted with the process of the preparation of the vaccine, we believe that it is an agent that should exhibit the immunizing properties, if any exist, of the micro-organisms used in its preparation.  Each cubic centimeter contains, approximately:    Two or more strains of each organism were used.  The dose used was 0.5 c.c. at the first injection, 1 c.c. at the second and 1.5 c.c. at the third. The interval between the injections was forty-eight hours.  The persons vaccinated were patients at a state institution for the insane. Only patients of 41 years of age or
Trans-Fatty Acid Levels in White Adults
Authors: Eric Brandt
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE CARRIAGE OF IMMUNOLOGICAL MEMORY BY SMALL LYMPHOCYTES IN THE RAT
Authors: James L. Gowans, Jonathan W. Uhr
Journal: The Journal of Experimental Medicine (1966)

Lymphocytes were obtained from the thoracic duct of rats 1(1/2) to 15 months after primary immunization with a single dose of bacteriophage phiX 174. An intravenous injection of these lymphocytes conferred on heavily X-irradiated rats the ability to form antibody in a secondary-type manner after a first injection of phiX. Negligible responses were obtained after cell transfer if the recipients were not challenged with antigen. Thoracic duct cells from some immunized donors were incubated in vitro for 24 hr before transfer in order to destroy selectively the large, dividing lymphocytes. The responsiveness conferred on X-irradiated recipients by such "incubated" inocula was then compared with that given by equal numbers of "fresh" thoracic duct cells. In all such comparisons the recipients of the "incubated" cells gave higher and more rapid antibody responses. It was concluded that the cells in thoracic duct lymph which carried immunological memory were small lymphocytes.
Distribution of ventilation and frequency-dependence of dynamic lung compliance
Authors: S. T. Chiang
Journal: Thorax (1971)

Lung components were analysed and dynamic pulmonary compliance was determined in 10 young healthy female subjects and seven adult male patients with bronchial obstruction. In normal subjects with a single ventilatory component (by multiple breath nitrogen washout method) a change of respiratory frequency did not affect dynamic lung compliance. Other normal subjects had two ventilatory components; in them and in the patients with bronchial obstruction, an increase of respiratory frequency decreased dynamic pulmonary compliance. A change of respiratory rate caused a greater change of dynamic lung compliance in the patients with bronchial obstruction than in normal subjects with two-component lungs. The results indicate that frequency-dependence of compliance and non-uniform distribution of inspired gas are caused by a similar mechanism. Inequality of regional time constants may be an important factor in this mechanism. The data also show that a decrease of dynamic lung compliance by more than 20% at a respiratory rate of 80 to 100 breaths/minute may be indicative of lung disease with obstruction.
High-Dose Chemotherapy for Breast Cancer
Authors: Daniel A. Rushing
Journal: Annals of Internal Medicine (1997)

Letters1 June 1997High-Dose Chemotherapy for Breast CancerDaniel A. Rushing, MDDaniel A. Rushing, MDMarshfield Clinic, Marshfield, WI 54449Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-126-11-199706010-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In their article on high-dose chemotherapy for breast cancer, Gradishar and colleagues [1] state in their conclusions that they believe the barrier to the completion of the “pivotal phase III trials” is “preconceived preference to therapy.” First, I believe that for those physicians who are reluctant to place patients in such phase III trials, the issue is ethics and not personal preference. For some of us, the issue is whether we randomly assign a patient to a treatment that we believe has no hope of cure or to a treatment that does have a chance of cure ...References1. Gradishar WJ, Tallman MS, Abrams JS. High-dose chemotherapy for breast cancer. Ann Intern Med. 1996; 125:599-604. Google Scholar2. Philip T, Guglielmi C, Hagenbeek A, Somers R, Van der Lelie H, Bron D, et al. Autologous bone marrow transplantation as compared with salvage chemotherapy in relapses of chemotherapy-sensitive non-Hodgkin's lymphoma. N Engl J Med. 1995; 333:1540-5. Google Scholar3. Eilber F, Giuliano A, Eckardt J, Patterson K, Moseley S, Goodnight J. Adjuvant chemotherapy for osteosarcoma: a randomized prospective trial. J Clin Oncol. 1987; 5:21-6. Google Scholar4. Holland JF. Adjuvant chemotherapy of osteosarcoma: no runs, no hits, two men left on base [Editorial]. J Clin Oncol. 1987; 5:4-6. Google Scholar5. Einhorn LH, Donohue J. Cis-diamminedichloroplatinum, vinblastine and bleomycin combination chemotherapy in disseminated testicular cancer. Ann Intern Med. 1977; 87:293-8. Google Scholar Author, Article, and Disclosure InformationAuthors: Daniel A. Rushing, MDAffiliations: Marshfield Clinic, Marshfield, WI 54449 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEthical issues in autologous stem cell transplantation (ASCT) in advanced breast cancer: A systematic literature reviewNew Developments in High-Dose Chemotherapy for Breast Cancer 1 June 1997Volume 126, Issue 11Page: 917KeywordsBreast cancerChemotherapyClinical trialsDisease free survivalHigh-dose chemotherapyLymphomaPatientsPhase 2 trialsRandomized trialsTesticular cancer ePublished: 15 August 2000 Issue Published: 1 June 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Differentiation of Malignant and Degenerative Benign Bone Disease Using Tc-99m MDP and Tc-99m Citrate Scintigraphy
Authors: RAJNISH SHARMA, ANUPAM MONDAL, ASEEM BHATNAGAR, K. L. CHAKRAVARTY, PUSHPA MISHRA, M. K. CHOPRA, H. S. RAWAT, RAVI KASHYAP
Journal: Clinical Nuclear Medicine (1998)

The authors present a prospective analysis of Tc-99m MDP and Tc-99m citrate scintigraphy in 108 patients with known malignant or degenerative benign bone disease. Of 108 patients, 59 (group A) had malignant bone disease. The other 49 patients (group B) had degenerative benign bone disease for which the results of Tc-99m MDP scans were positive. In both groups the Tc-99m citrate scan was performed 1 week after the Tc-99m MDP scan. The Tc-99m citrate/Tc-99m MDP lesion-to-background radioisotope uptake ratio (RUR) was calculated for each lesion 3 hours after radionuclide administration. The mean RUR for the malignant lesions was 1.0 +/- 0.484; for the benign lesions, the RUR was 0.29 +/- 0.250. Static imaging was also done for 10 lesions each from the malignant and benign groups at 1, 3, and 24 hours to study the kinetics of Tc-99m citrate. Time-activity curves for malignant lesions showed that the RUR remained high for 24 hours, whereas benign lesions showed a drastic decrease at 3 and 24 hours compared with the 1-hour images. The ratio of Tc-99m citrate to Tc-99m MDP is a promising parameter to differentiate malignant from benign degenerative lesions seen as areas of increased activity on Tc-99m MDP bone scans. The sensitivity and specificity of this technique were 97.8% and 95%, respectively.
"Unlawfully treated" woman to move to new unit
Authors: C. Dyer
Journal: BMJ (2002)

A quadriplegic woman on a ventilator who won a court ruling last week giving her the right to die is expected to move after Easter to an intensive care unit willing to carry out her wishes. England's senior family judge ruled that the woman was mentally competent to take treatment decisions and may therefore opt to come off the ventilator.

Dame Elizabeth Butler-Sloss held that the unnamed NHS trust caring for the 43 year old former senior social worker, named only as Ms B, had been treating her unlawfully since last August, when a psychiatrist assessed her as competent.

Ms …
Partial characterization and clinical correlation of circulating human immunoglobulins directed against thyrotrophin binding sites in guinea pig fat cell membranes. Development of a direct enzyme immunoassay.
Authors: J R Baker, Y G Lukes, R C Smallridge, M Berger, K D Burman
Journal: Journal of Clinical Investigation (1983)

To obviate several problems inherent in indirect thyroid-stimulating hormone (TSH) receptor antibody assays, we developed an enzyme-linked immunosorbent assay (ELISA) that measures antibodies binding to guinea pig fat cell membrane, which contain high concentrations of TSH receptors. Solubilized guinea pig fat cell membranes were adsorbed to plastic microtiter plates and served as the solid-phase antigen. Test sera and affinity-purified alkaline phosphatase-conjugated anti-human IgG were co-incubated with membranes, after which p-nitrophenyl phosphate was added. Results were read when a positive control reached a standard color change (OD405nm). Specificity of this assay was demonstrated by the inability of albumin, insulin, TSH subunits, propranolol, or dexamethasone to block binding 30. normal subjects had a mean OD value of 0.080 +/- 0.050 (SD). 23 of 25 untreated Graves' patients had OD values at least 2 SD above the normal mean (Grave's mean +/- SD; 0.46 +/- 0.33, P less than 0.001) and in each case 10(-6) M TSH inhibited the binding by at least 60%, suggesting that the immunoglobulins were directed at the TSH receptor. Seven of 25 serum samples from patients with Hashimoto's disease, seven of 23 serum samples from patients with transient hyperthyroidism (subacute thyroiditis or painless thyrotoxic thyroiditis), and two of 10 samples from patients with thyroid carcinoma had significant elevations in the titers of membrane-directed immunoglobulins. Graves' patients who were treated with ablative therapy at least 6 mo earlier and who were euthyroid when restudied continued to have abnormally elevated membrane-directed immunoglobulins in six of eight samples studied. Further studies involved the substitution of affinity-purified alkaline phosphatase anti-IgM antisera for the anti-IgG antisera routinely used. Seven of 12 serum samples from patients with Graves' disease had significant elevations in binding which in every instance was inhibited by greater than 60% by 10(-6) M TSH. In sum, the present results indicate that (a) we have developed a sensitive, specific, reproducible, convenient ELISA for the measurement both of the total amount of circulating membrane-directed antibodies and of TSH-displaceable membrane-directed immunoglobulins. (b) This ELISA detected significant elevations in TSH-displaceable guinea pig membrane binding in 23 of 25 untreated Graves' patients as well as in approximately 30% of patients with Hashimoto's thyroiditis and subacute thyroiditis. (c) Elevated membrane directed antibodies may continue to be present many months or years after restoration of the euthyroid state. (d) Circulating membrane binding IgM immunoglobulins have been detected in patients with Graves' disease. Further studies using this ELISA should prove useful in a variety of investigative and clinical studies.
GMC decision in Southall case challenged in High Court
Authors: Clare Dyer
Journal: BMJ (2005)

The consultant paediatrician David Southall will have to wait until after Easter to learn whether he will be struck off the medical register for accusing a father of murdering his two sons after seeing him in a television documentary.

Professor Southall escaped erasure by the General Medical Council, which suspended him from child protection work for three years, but the penalty was challenged in the High Court last week as “unduly lenient.” The Council for Healthcare Regulatory Excellence, the body that oversees regulators in the health field, argued that erasure …
Endoscopic ultrasound-guided fine needle aspiration diagnosis of extramedullary hematopoiesis in mediastinum
Authors: M. Bosco, P. Carucci, D. Pacchioni, M. Bruno, M. Rizzetto, G. Bussolati, C. De Angelis
Journal: Endoscopy (2009)

An 84-year-old woman with thrombotic thrombocytopenic purpura and a past history of bladder carcinoma underwent radiography that disclosed a huge intrathoracic mass, confirmed by CT.
Assessing Risk in Hypertrophic Cardiomyopathy
Authors: Richard O. Cannon
Journal: New England Journal of Medicine (2003)

Hypertrophic cardiomyopathy has fascinated clinicians and clinical investigators since its initial description almost 50 years ago because of the unique physical findings, often bizarre electrocardiographic aspects, unusual shape of the left ventricle on contrast ventriculography, typically asymmetric distribution of hypertrophy on echocardiography, and abnormal filling of the left ventricle in diastole. Some aspects of the disease have generated considerable controversy, such as the mechanism (and even the existence) of dynamic intraventricular pressure gradients in some patients.No less contentious is the debate about how clinicians might predict the most feared complication of this disease: sudden death. Although clinical predictors of . . .
Genome and transcriptome of the porcine whipworm Trichuris suis
Authors: Aaron R Jex, Peter Nejsum, Erich M Schwarz, Li Hu, Neil D Young, Ross S Hall, Pasi K Korhonen, Shengguang Liao, Stig Thamsborg, Jinquan Xia, Pengwei Xu, Shaowei Wang, Jean-Pierre Y Scheerlinck, Andreas Hofmann, Paul W Sternberg, Jun Wang, Robin B Gasser
Journal: Nature Genetics (2014)

Trichuris (whipworm) infects 1 billion people worldwide and causes a disease (trichuriasis) that results in major socioeconomic losses in both humans and pigs. Trichuriasis relates to an inflammation of the large intestine manifested in bloody diarrhea, and chronic disease can cause malnourishment and stunting in children. Paradoxically, Trichuris of pigs has shown substantial promise as a treatment for human autoimmune disorders, including inflammatory bowel disease (IBD) and multiple sclerosis. Here we report whole-genome sequencing at ∼140-fold coverage of adult male and female T. suis and ∼80-Mb draft assemblies. We explore stage-, sex- and tissue-specific transcription of mRNAs and small noncoding RNAs.
Uptake of SLE autoantibodies by podocytes
Authors: Anja Hillmann, Hedda Wardemann, Thomas Pap, Annett Jacobi
Journal: Annals of the Rheumatic Diseases (2012)

<h3>Backgroundand objectives</h3> Systemic lupus erythematosus (SLE) is an autoimmune disease, resulting in inflammation and tissue damage in several organs. This autoimmune reaction is caused by antibodies against dsDNA (adsDNAabs). Most patients with SLE develop joint pain and about 70% develop renal symptoms, partly with lupus nephritis leading to proteinuria. It is still unclear why the kidney and especially the podocytes (filtrating cells of the renal glomerulus) are involved in such a dramatic manner during SLE. <h3>Methods</h3> Anti dsDNA antibodies were isolated from SLE-patients, cloned and produced recombinantly in HEK293 cells. Podocytes were treated with equal amounts of different adsDNAabs and control antibodies in time and concentration dependent experiments and examined by immunofluorescence. To investigate the degradation mechanism, cells were treated with Bafilomycine A or MG132 at different time points of co-cultivation with the antibodies. <h3>Results</h3> Cultivated podocytes take up adsDNA-antibodies selectively and aggregate them in cytosolic speckles. The uptake of adsDNAabs occurs in a concentration and time dependent manner. The authors found podocytes with up to 80 aggregates per cell. The aggregates are eliminated over time in media without adsDNAabs (recovery experiment). The authors could show that the adsDNAabs are degraded by autophagy, which leads to a better survival of the cells. The number of aggregates after the inhibition of autophagy rises significantly up to twofold. The number of aggregates of podocytes treated with a control antibody is almost zero. <h3>Conclusion</h3> Podocytes are postmitotic and highly complex cells. Loss of these cells leads to kidney injury and proteinuria. During lupus-nephritis, podocytes are destroyed. The authors could show that these cells take up SLE-antibodies selectively and are harmed by these antibody-aggregates. The authors could show that induction of autophagy can help to eliminate the aggregates. This should be considered for future therapeutic approaches in lupus nephritis.
Fibrinolytic activity and clotting factors in ischaemic heart disease in women
Authors: T W Meade, J A Cooper, R Chakrabarti, G J Miller, Y Stirling, D J Howarth
Journal: BMJ (1996)

Low fibrinolytic activity and raised levels of clotting factors have been linked with increased incidence of ischaemic heart disease in men.1 2 3 Information in women, however, is confined to a relation of high fibrinogen concentrations with ischaemic heart disease in the Framingham study.3 This report describes the possible association of low fibrinolytic activity with fatal ischaemic heart disease in women.

The Northwick Park heart study included 695 women aged 40-64 at entry in 1972-8. The methods and assessment of deaths attributed to ischaemic heart disease were as described for the men.1 By the end of 1994, 74 women had died: 19 from ischaemic heart disease, 16 from other cardiovascular diseases, 28 from cancer, and 11 from other causes. Fibrinolytic activity is …
Histopathological and ultrastructural studies of synovium in Milwaukee shoulder syndrome--a basic calcium phosphate crystal arthropathy.
Authors: P B Halverson, J C Garancis, D J McCarty
Journal: Annals of the Rheumatic Diseases (1984)

Light and electron microscopic study of synovial specimens from four patients with the Milwaukee shoulder syndrome disclosed vascular congestion, villous and focal synovial lining cell hyperplasia, occasional giant cells, and fibrin deposition both within and on the surface of the synovium. Although these changes are non-specific, the finding of basic calcium phosphate crystal aggregates in all four cases and the near total absence of an inflammatory reaction are helpful in distinguishing this condition from other types of arthritis. The focal areas of synovial cell hyperplasia may relate to the powerful mitogenic effect of both synthetic and naturally occurring calcium-containing crystals in concentrations found in the synovial fluid of these patients.