Hairy Cell Leukemia: A Five-Year Update on Seventy-One Patients
Authors: HARVEY M. GOLOMB
Journal: Annals of Internal Medicine (1983)

Brief Reports1 October 1983Hairy Cell Leukemia: A Five-Year Update on Seventy-One PatientsHARVEY M. GOLOMB, M.D., DANIEL CATOVSKY, M.D., DAVID W. GOLDE, M.D.HARVEY M. GOLOMB, M.D.Search for more papers by this author, DANIEL CATOVSKY, M.D.Search for more papers by this author, DAVID W. GOLDE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-99-4-485 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHairy cell leukemia, although rare, has become a well-described clinicopathologic entity since its identification in 1958 (1). Patients with the disease have circulating leukemic cells with prominent cytoplasmic projections. These cells are tartrate-resistant acid-phosphatase-positive in cytochemical tests. These cytochemical features, combined with a characteristic pattern of bone marrow involvement, are diagnostic for hairy cell leukemia (2, 3). Clinically, most patients have splenomegaly without adenopathy. Usually, a pancytopenia is present, but 10% to 20% of patients have an elevated leukocyte count, most of these leukocytes being hairy cells (4, 5).Splenectomy has been recommended as the initial treatment when therapy is...References1. BOURONCLEWISEMANDOAN BBC. Leukemic reticuloendotheliosis. Blood. 1958;13:609-30. CrossrefMedlineGoogle Scholar2. YAMLILAM LCK. Tartrate-resistant acid phosphatase isoenzyme in the reticulum cells of leukemic reticuloendotheliosis. N Engl J Med. 1971;284:357-60. CrossrefMedlineGoogle Scholar3. NAEIMSMITH FG. Leukemic reticuloendotheliosis. Cancer. 1974;34:1813-21. CrossrefMedlineGoogle Scholar4. CATOVSKY D. Hairy-cell leukaemia and prolymphocytic leukaemia. Clin Haematol. 1977;6:245-68. CrossrefMedlineGoogle Scholar5. BURKEBYRNERAPPAPORT JGH. Hairy cell leukemia (leukemic reticuloendotheliosis): I. A clinical pathologic study of 21 patients. Cancer. 1974;33:1339-410. CrossrefGoogle Scholar6. GOLOMB H. Progress report on chlorambucil therapy in postsplenectomy patients with progressive hairy cell leukemia. Blood. 1981;57:464-7. CrossrefMedlineGoogle Scholar7. GOLOMBCATOVSKYGOLDE HDD. Hairy cell leukemia: a clinical review based on 71 cases. Ann Intern Med. 1978;89:677-83. LinkGoogle Scholar8. BOURONCLE B. Leukemic reticuloendotheliosis (hairy cell leukemia). Blood. 1979;53:412-36. CrossrefMedlineGoogle Scholar9. GOLOMBHANAUER HS. Infectious complications associated with hairy cell leukemia. J Infect Dis. 1981;143:639-43. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Chicago Hospitals and Clinics Chicago, Illinois Royal Postgraduate Medical School London England UCLA School of Medicine Los Angeles, California PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIt’s a BRAF new world for hairy cell leukemiaHairy Cell LeukemiaHairy Cell LeukemiaHairy Cell LeukemiaTowards the pharmacotherapy of hairy cell leukaemiaSplenectomy and treatments of historical interestHairy Cell LeukemiaClonal chromosome rearrangements in hairy cell leukemiaCurrent Clinical Practice: Treatment of Hairy Cell Leukemia at the Close of the 20th CenturyInterferon therapy of hematologic malignanciesOcular Manifestation of Hairy Cell Leukemia With Dramatic Response to 2-Chloro-deoxy-adenosinePanuveitis responsive to 2-cda: an unusual ocular presentation of hairy cell leukemiaSplenectomy in Lymphoproliferative Disorders: A Report on 70 Cases and Review of the LiteratureSplenectomy vs. alpha interferon: A randomized study in patients with previously untreated hairy cell leukemiaNon-Hodgkin-LymphomeHairy Cell Leukemia: Residual Splenic Disease After Successful α 2 b -Interferon TherapyFludarabine phosphate in refractory hairy cell leukemiaHairy Cell Leukemia and Its T Cell InteractionsHairy cell leukemia:Characteristics of the neoplastic cellsHairy cell leukemia: clinical features and therapeutic advancesSpectrum and frequency of autoimmune derangements in lymphoproliferative disorders: analysis of 637 cases and comparison with myeloproliferative diseases*Spectrum and frequency of autoimmune derangements in lymphoproliferative disorders: analysis of 637 cases and comparison with myeloproliferative diseasesDie Diagnose und Prognose der Haarzell-LeukämieLa leucémie à tricholeucocytes. 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FOON, M.D.HAIRY-CELL LEUKAEMIAHairy cell leukaemia and legionnaires' diseaseCorrection: Error in Legend to Graph on Hairy Cell Leukemia 1 October 1983Volume 99, Issue 4Page: 485-486KeywordsBone marrowBone marrow cellsInterleukinsMedical servicesResearch fundingSplenectomySplenomegaly ePublished: 1 December 2008 Issue Published: 1 October 1983 PDF downloadLoading ...