tbuckley/cabot-search huggingface dataset:
NF-Y–Dependent Cyclin B2 Expression in Colorectal Adenocarcinoma
Authors: Seon-Hwa Park, Gyung-Ran Yu, Woo-Ho Kim, Woo-Sung Moon, Jong-Hun Kim, Dae-Ghon Kim
Journal: Clinical Cancer Research (2007)

Cyclin B2, a G(2)-M cyclin, is overexpressed in colorectal adenocarcinomas compared with the normal mucosa. This study examined the level of cyclin B2 overexpression according to the histologic findings and investigated the mechanism(s) and clinical implications of cyclin B2 overexpression in colorectal adenocarcinomas.The immunoreactivity of the polyclonal antibodies to cyclin B2 was determined in colorectal cancer cells. The transcriptional regulation of cyclin B2 by NF-Y was analyzed using an in vitro transfection assay and an in vivo chromatin immunoprecipitation assay. The proliferative activity of the colorectal cancer cells in relation to cyclin B2 overexpression was further examined.The cytoplasmic distribution of cyclin B2 immunoreactivity was positive in 42 of 65 (64.6%) cases of colorectal adenocarcinoma, and the level was similar regardless of the histologic type. A dominant-negative form of NF-YA effectively inhibited the cyclin B2 promoter activity, and NF-Y was found to bind three conserved CCAAT boxes in the cyclin B2 promoter in colorectal adenocarcinoma cells. Tumor cells with a higher functional cyclin B2 activity grew faster than those with a lower activity. Furthermore, there was a correlation between the cells showing immunoreactivity to cyclin B2 and those containing the proliferating cell nuclear antigen, a G1-S cyclin, which is also downstream of NF-Y in colorectal adenocarcinoma cells.Cyclin B2 seems to be a molecular marker of a colorectal adenocarcinoma and that its up-regulation and coordinate expression of the other cell cycle-related genes by NF-Y might contribute to tumor cell proliferation by accelerating cell cycle progression.
Ga-67 Citrate and Tc-99m HMPAO Leukocyte Scanning in Extrapulmonary Tuberculosis
Authors: L PRAT, M T BAJ??N, Y RICART, M ROCA, J MORA, J MARTIN-COMIN
Journal: Clinical Nuclear Medicine (1991)

A 32-year-old man had disseminated tuberculosis. A Ga-67 citrate scan showed lymph node uptake in the mediastinum, left lung hilus, and retroperitoneum. Tc-99m HMPAO WBC scans showed ileocecal activity, and a culture demonstrated the growth of mycobacterium tuberculosis.
Systemic and splanchnic hemodynamic changes after liver transplantation for cirrhosis: A long-term prospective study
Authors: Fabio Piscaglia, Gianni Zironi, Stefano Gaiani, Alighieri Mazziotti, Antonino Cavallari, Laura Gramantieri, Marco Valgimigli, Luigi Bolondi
Journal: Hepatology (1999)

The effect of orthotopic liver transplantation (OLT) on the systemic and splanchnic hemodynamic alterations of cirrhosis is still largely unknown. The aim of this study was to prospectively investigate the long-term changes induced by OLT on several hemodynamic parameters. In 28 patients undergoing OLT for cirrhosis, the following parameters were measured before surgery and subsequently at 6-month intervals (mean follow-up period, 17 months): cardiac index, mean arterial pressure (MAP), heart rate, total peripheral resistance (TPR), portal vein flow velocity and flow volume, spleen size, and Doppler ultrasound resistance or pulsatility indexes (RI or PI) in the: 1) interlobular renal, 2) superior mesenteric, 3) splenic, and 4) hepatic arteries. The same parameters were measured in 10 healthy controls. After OLT, cardiac index and heart rate significantly decreased ( P &lt; .01), while MAP and TPR increased ( P &lt; .001), so that any significant difference from controls disappeared. Renal RI progressively decreased, achieving a significant reduction ( P &lt; .05) to normal values at the 12th month of follow-up. Portal flow velocity and hepatic and splenic RI returned to values not significantly different from controls. Portal flow volume increased over normal values after OLT ( P &lt; .001), and SMA PI, lower than normal before OLT, did not show any statistically significant increase thereafter. Spleen size decreased significantly, but persisted to be larger than in controls. In conclusion, systemic, renal, and most, but interestingly not all, splanchnic circulatory alterations of cirrhosis are restored to normal after OLT.
ABCB1 Genetic Effects on Antidepressant Outcomes: A Report From the iSPOT-D Trial
Authors: Alan F. Schatzberg, Charles DeBattista, Laura C. Lazzeroni, Amit Etkin, Greer M. Murphy, Leanne M. Williams
Journal: American Journal of Psychiatry (2015)

The ABCB1 gene encodes P-glycoprotein, which limits brain concentrations of certain antidepressants. ABCB1 variation has been associated with antidepressant efficacy and side effects in small-sample studies. Cognitive impairment in major depressive disorder predicts poor treatment outcome, but ABCB1 genetic effects in patients with cognitive impairment are untested. The authors examined ABCB1 genetic variants as predictors of remission and side effects in a large clinical trial that also incorporated cognitive assessment.The authors genotyped 10 ABCB1 single-nucleotide polymorphisms (SNPs) in 683 patients with major depressive disorder treated for at least 2 weeks, of whom 576 completed 8 weeks of treatment with escitalopram, sertraline, or extended-release venlafaxine (all substrates for P-glycoprotein) in a large randomized, prospective, pragmatic trial. Antidepressant efficacy was assessed with the 16-item Quick Inventory of Depressive Symptomatology-Self-Rated (QIDS-SR), and side effects with a rating scale for frequency, intensity, and burden of side effects. General and emotional cognition was assessed with a battery of 13 tests.The functional SNP rs10245483 upstream from ABCB1 had a significant effect on remission and side effect ratings that was differentially related to medication and cognitive status. Common homozygotes responded better and had fewer side effects with escitalopram and sertraline. Minor allele homozygotes responded better and had fewer side effects with venlafaxine, with the better response most apparent for patients with cognitive impairment.The functional polymorphism rs10245483 differentially affects remission and side effect outcomes depending on the antidepressant. The predictive power of the SNP for response or side effects was not lessened by the presence of cognitive impairment.
Solar Protection by Hair
Authors: Shunjie Chua, Jing Li
Journal: JAMA Pediatrics (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
VARIATION OF APOLIPOPROTEIN-B GENE IS ASSOCIATED WITH OBESITY, HIGH BLOOD CHOLESTEROL LEVELS, AND INCREASED RISK OF CORONARY HEART DISEASE
Authors: J Rajput-Williams, S.C Wallis, J Yarnell, G.I Bell, T.J Knott, P Sweetnam, N Cox, N.E Miller, J Scott
Journal: The Lancet (1988)
Clinical significance of different antiphospholipid antibodies in the WAPS (warfarin in the antiphospholipid syndrome) study
Authors: Monica Galli, Giovanna Borrelli, Eva Marie Jacobsen, Rosa Maria Marfisi, Guido Finazzi, Roberto Marchioli, Finn Wisloff, Stefana Marziali, Olivier Morboeuf, Tiziano Barbui
Journal: Blood (2007)
Vitamin C depletion and pressure sores in elderly patients with femoral neck fracture.
Authors: H. F. Goode, E. Burns, B. E. Walker
Journal: BMJ (1992)

To evaluate the contribution of specific nutritional deficiencies (as indicated by zinc; vitamin A, C, and E; albumin; and haemoglobin concentrations) to the risk of pressure sores.Observational cohort study.St James's University Hospital, Leeds.21 elderly patients presenting consecutively to the orthopaedic unit with femoral neck fracture.Full thickness epidermal break over a pressure bearing surface.10 patients (48%) developed a pressure sore during their hospital stay. Indices of zinc status and concentrations of albumin, haemoglobin, and vitamins A and E were similar in patients who developed a pressure sore and those who did not. Mean leucocyte vitamin C concentration, however, was 6.3 (SD 2.2) micrograms/10(8) cells in patients who developed a pressure sore as compared with 12.8 (4.6) micrograms/10(8) cells in patients who did not.Low concentrations of leucocyte vitamin C appear to be associated with subsequent development of pressure sores in elderly patients with femoral neck fractures.
G-6-PD Deficiency, Sickle Cell Trait, and Acute Hemolysis After Bronchography
Authors: Robert L. Richardson
Journal: JAMA (1969)

Acute hemolysis in a patient with sickle cell trait and glucose-6-phosphate-dehydrogenase deficiency was observed following a bronchogram with a sulfa-containing medium. We believe the acute episode was precipitated by the combination of hypoxia during the procedure and the ingestion of sulfa compound.
Effect of Cholecystectomy on the Relationship between Hydrostatic Common Bile Duct Pressure and Sphincter of Oddi Motility
Authors: P. Rolny, P. Funch-Jensen, A. Kruse, P. Thommesen
Journal: Endoscopy (1991)

The sphincter of Oddi (SO) motility before and after an artificial elevation of the common bile duct pressure was studied by means of endoscopic manometry in nine female subjects, seven of whom had undergone previous cholecystectomy. An increase in the hydrostatic common bile duct pressure resulted in total inhibition of the phasic SO contractions in the two patients with gallbladders in situ, as well as in four of the cholecystectomized patients. The results thus indicate that the inhibitory effect of hydrostatic common bile duct pressure on the SO motility previously demonstrated in the cat is also present in man. On the other hand, as the inhibition of the phasic contractions failed to occur in three of the postcholecystectomy patients, the findings also suggest that cholecystectomy may result in altered regulation of SO motility in some patients. This mechanism could then contribute to development of pain in susceptible subjects postcholecystectomy. Finally, the results also showed that pain experienced by some patients upon contrast injection during ERCP bears no relationship to SO motility, but is due to an interindividually variable sensitivity of the bile duct wall to the intraluminal pressure variation.
Value of Programmed Ventricular Stimulation After Tetralogy of Fallot Repair
Authors: Paul Khairy, Michael J. Landzberg, Michael A. Gatzoulis, Hugues Lucron, Jean Lambert, François Marçon, Mark E. Alexander, Edward P. Walsh
Journal: Circulation (2004)

Studies have consistently shown that ventricular tachycardia (VT) and sudden cardiac death (SCD) complicate the long-term outcome after tetralogy of Fallot repair, yet the diagnostic and predictive value of electrophysiological testing in this population is uncertain.A multicenter cohort of 252 patients with repaired tetralogy of Fallot undergoing programmed ventricular stimulation was followed up for 18.5+/-9.6 and 6.5+/-4.5 years after corrective surgery and electrophysiological testing, respectively. Clinical VT and/or SCD occurred in 24.6%. Sustained monomorphic VT and polymorphic VT were induced in 30.2% and 4.4%. Including polymorphic VT in the definition of inducibility improved sensitivity (66.1+/-6.0% versus 77.4+/-5.3%, P=0.0082) with a marginal reduction in specificity (81.6+/-2.8% versus 79.5+/-2.9%, P=0.0455). Positive and negative predictive values were 55.2+/-5.3% and 91.5+/-2.2%. Independent risk factors for inducibility were age at study > or =18 years (OR, 3.3), palpitations (OR, 2.8), prior palliative surgery (OR, 3.1), modified Lown criteria > or =2 (OR, 5.6), and cardiothoracic ratio > or =0.6 (OR, 3.3). Event-free survival rates in noninducible and inducible patients at 1, 5, 10, and 15 years were 97.9%, 92.8%, 89.3%, and 89.3% versus 79.4%, 62.6%, 58.7%, and 50.3%, respectively (P<0.0001). Both inducible monomorphic VT [relative risk (RR), 5.0; P=0.0002] and polymorphic VT (RR, 12.9; P<0.0001) predicted future clinical VT and SCD. In a multivariate analysis, inducible sustained VT was an independent risk factor for subsequent events (RR, 4.7; 95% CI, 1.2 to 18.5; P=0.0268).Programmed ventricular stimulation is of diagnostic and prognostic value in risk stratifying patients with repaired tetralogy of Fallot. In this patient population, inducible sustained polymorphic VT should not be disregarded as nonspecific.
In praise of a paper journal
Authors: Kamran Abbasi
Journal: Journal of the Royal Society of Medicine (2011)

A JRSM reader recently told me that she was switching back to the print publication because visiting the website (jrsm.rsmjournals.com) to read JRSM wasn't part of her routine and was never likely to be. The only way to read JRSM, then, was to pick up the print edition.

We know visitors to journal websites are usually seeking specific information, a particular article that they have discovered via a web search. They may not necessarily be regular readers of your journal, and have no particular loyalty to it. Reading one article is unlikely to convert them into regular readers. The first challenge for journals, therefore, is to develop online services that will be valuable to readers and are not possible in print.

Despite radio, television, the Internet, and now Kindle, people still enjoy reading a book or a journal in print. Will print journals ever disappear entirely? Many will die – eventually – but plenty will survive to satisfy our desire for touching words on a page. The journals that endure will publish much else besides research. They will major on editorials, essays and reviews. They will synthesize knowledge for a community instead of publishing random bites of information. They will also need to entertain. The second challenge for journals, therefore, is to develop a print version that will be valuable to readers without publishing research.

None of this is new, these prophecies have been written for more than a decade, but the challenge is more immediate. Online-only journals, many with an author-pays model like JRSM Short Reports (shortreports.rsmjournals.com), are attracting a larger number of submissions. Their value is in publishing research quickly and being less selective about their publication policies. JRSM Short Reports is now on PubMed Central and we have applied for full indexing. The online world is moving rapidly in terms of publication of research.

Meanwhile, the print world is more sedate but it needs to quicken its speed of change. Bigger, richer, weekly journals have sufficient resources to adapt and have an in built inertia that can weather the winds of change. The predicament is more acute for smaller journals, and their battle for survival, because of the laws of economics, will become more acute. These are dangerous times.

JRSM floats somewhere between the big beasts of the publishing ocean and the minnows battling for survival, although our aspiration is to swim with big beasts rather than be consumed like minnows. As such, we are considering the next stage in the evolution of both print and online versions of JRSM. We have many ideas for development but we welcome suggestions from JRSM readers about how the journal might better serve their needs in print and online while positioning itself cleverly for the future of medical journals.
Effect of gastrin on gastric mucosal cell proliferation in man.
Authors: O H Hansen, T Pedersen, J K Larsen, J F Rehfeld
Journal: Gut (1976)

The effect of short-term infusion of a large dose of pentagastrin and a small dose of synthetic human gastrin I (SHG) on the rate of cell proliferation in gastric mucosa was studied in normal human subjects. Moreover, the kinetic parameters were compared with the serum gastrin concentrations in fasting patients. Endoscopic biopsies were labelled in vitro with 3H-thymidine and autoradiographs were prepared. The percentage of DNA-synthesising cells in the progenitor cell region was estimated. In healthy volunteers infusion of a large dose of pentagastrin (10 mug/kg per hour) was followed by a marked increase in the labelling index in fundic mucosa. The antral mucosa was not responsive to this effect. In the same subjects, infusion of a low dose of SHG (8 ng/kg per min) did not affect the rate of cell proliferation, either in fundic or in antral mucosa. In 46 patients with different gastric diseases no correlation between the serum gastrin concentrations and the labelling indices was found. The results suggest that human fundic mucosa is responsive to a trophic action of pentagastrin. If it exists, however, a physiological action of gastrin as a trophic hormone for human gastric mucosa must be considerably more complex than previously believed.
Outcome of ascites in bleeding cirrhotic patients treated with portacaval anastomosis (PCA) or sclerotherapy (ES)
Authors: M.C. Gomes-Vieira, R. Planas, R. Mcrillas, H. Broggi, J. Boix, A. Abad-Lacruz, M. Armengol, P. Humbert, J.A. Salva, M.A. Gassull
Journal: Journal of Hepatology (1990)
Hospital and Domiciliary Control of Tuberculosis
Authors: H. Stevens
Journal: BMJ (1950)

BDICA JOURNL_ 639_The uninterrupted reports of success with dimercaprol in cases of metallic poisoning may encourage the use of higher dosage of gold in the treatment of chronic rheumatism.I am indebted to many colleagues for help with the preparation of this paper; particularly to Miss M. Roberts, assistant city analyst, Liverpool, for the gold estimations in Case 2. I am grateful to Dr.
Expression of G <sub>qα</sub> and PLC-β in Scar and Border Tissue in Heart Failure Due to Myocardial Infarction
Authors: Haisong Ju, Shufang Zhao, Paramjit S. Tappia, Vincenzo Panagia, Ian M. C. Dixon
Journal: Circulation (1998)

Background —Large transmural myocardial infarction (MI) leads to maladaptive cardiac remodeling and places patients at increased risk of congestive heart failure. Angiotensin II, endothelin, and α 1 -adrenergic receptor agonists are implicated in the development of cardiac hypertrophy, interstitial fibrosis, and heart failure after MI. Because these agonists are coupled to and activate G qα protein in the heart, the aim of the present study was to investigate G qα expression and function in cardiac remodeling and heart failure after MI. Methods and Results —MI was produced in rats by ligation of the left coronary artery, and G qα protein concentration, localization, and mRNA abundance were noted in surviving left ventricle remote from the infarct and in border and scar tissues from 8-week post-MI hearts with moderate heart failure. Immunohistochemical staining localized elevated G qα expression in the scar and border tissues. Western analysis confirmed significant upregulation of G qα proteins in these regions versus controls. Furthermore, Northern analysis revealed that the ratios of G qα /GAPDH mRNA abundance in both scar and viable tissues from experimental hearts were significantly increased versus controls. Increased expression of phospholipase C (PLC)-β 1 and PLC-β 3 proteins was apparent in the scar and viable tissues after MI versus controls and is associated with increased PLC-β 1 activity in experimental hearts. Furthermore, inositol 1,4,5-tris-phosphate is significantly increased in the border and scar tissues compared with control values. Conclusions —Upregulation of the G qα /PLC-β pathway was observed in the viable, border, and scar tissues in post-MI hearts. G qα and PLC-β may play important roles in scar remodeling as well as cardiac hypertrophy and fibrosis of the surviving tissue in post-MI rat heart. It is suggested that the G qα /PLC-β pathway may provide a possible novel target for altering postinfarct remodeling.
COMMUNITY CARE OF THE MENTALLY DEFECTIVE
Authors: EDWARD J. HUMPHREYS
Journal: American Journal of Psychiatry (1941)

This paper presents the thesis that the subnormal should receive much more adequate community care and suggests certain possibilities for increasing the effectiveness of the treatment of this group. This thesis is developed by: (a) A general review of the estimated numerical extent of the subnormal in the total population with stress laid upon the degree to which the community is involved in the problem of the subnormal. (b) A suggested classification of the subnormal in the community on the basis of need for care and treatment according to which defectives would be assigned for (1) state school for mental defectives, (2) special institutional care, (3) community care. It is suggested that improved treatment will result from: (a) An enlargement of the concept of psychiatric work which will deal with the problems of the subnormal in more inclusive aspects, particularly as they are related to education and to economic adjustment. (b) A comprehensive state and community program of research, mental hygiene, education and social planning for the subnormal.
STUDIES OF HEMOGLOBINEMIA AND HEMOGLOBINURIA PRODUCED IN MAN BY INTRAVENOUS INJECTION OF HEMOGLOBIN SOLUTIONS
Authors: D. Rourke Gilligan, Mark D. Altschule, Evelyn M. Katersky
Journal: Journal of Clinical Investigation (1941)

Hemoglobinuria is a striking feature of several hemolytic disorders, such as blackwater fever, the various paroxysmal hemoglobinurias, and certain types of acute hemolytic anemia.Available in- formation indicates that hemoglobinuria in these conditions results from intravascular hemolysis with liberation of hemoglobin into the plasma.Quantitative studies of the plasma and urine hemoglobin and of pigments derived from hemo- globin have been made recently in this laboratory on several patients with hemoglobinuria.It was thought that comparison of the findings in normal individuals in whom hemoglobinemia and hemoglobinuria were induced by intravenous injections of hemoglobin solutions, together with the findings in clinical cases showing hemoglobinuria, might clarify certain aspects of these clinical problems.Sellards and Minot (1), Duesberg (2), and Ottenberg and Fox (3) have demonstrated that small amounts of stroma-free solutions of human hemoglobin may be injected in man without serious toxic reactions.The findings of these authors will be discussed below.METHODS Plosm Sli mgm.perIC Urine Hm and Urine Albui mgom oi 10.Hinj-1649m.
BURNS FROM ANESTHESIA MASK STERILIZED IN COMPOUND SOLUTION OF CRESOL
Authors: R. P. Herwick
Journal: JAMA (1933)

While burns following the application of compound solution of cresol to the skin are not uncommon, the following case will be of particular interest to anesthetists: H. S., a white girl, aged 16 years, was admitted to the orthopedic service for treatment of Pott's disease of the spine. An Albee spine graft was to be performed. The patient was anesthetized in the prone position with head resting in the face mask, thus applying a good deal of pressure against the rubber cushion. The anesthesia was of two hours' duration. When the face mask was removed it was noted that there was rather marked erythema of the face where contact had been made with the face cushion. The condition was believed to be due to the length of time during which the contact had been made. However, the condition became worse, with blistering of the skin across the bridge of the