tbuckley/cabot-search huggingface dataset:
Environmental and Social Influences on Skin Test Results in Children
Authors: Olavi Linna
Journal: Allergy (1983)

Skin test with 13 inhalant allergens were performed in 788 children with respiratory allergy. Positive reactions were common to animal danders (65%), to grass pollens (55%) and to tree pollens (44%) but rare to moulds (13%) and to house dust mite (12%). Children exposed to cows, dogs or horses at home more often had skin test reactions to the these allergens than the children not expose, but reactions to cat dander occured as frequently in children exposed to cat home as to those not exposed. Reactions to tree pollens occured most often in children from upper social classes and from urban and reactions to house dust mite occured most often in children from rural area. Children with positive reactions to house dust mite came from larger families than children with negative test results. Some of these results were unexpected and possible explanations are discussed.
Australia makes concessions on drug approvals after US pressure
Authors: Bob Burton
Journal: BMJ (2004)

Australia has bowed to pressure from the US government and agreed to major changes to its system of regulating drugs in a free trade agreement.

Public health advocates believe that the changes—advocated by the US drug industry—threaten thefoundations of Australia's pharmaceutical benefits scheme. Under the scheme, drugs can be approvedonly if recommended by the independent Pharmaceutical Benefits Advisory Committee, with their price benchmarked against generic drugs that deliver comparable health benefits (31 January p 247).

Although the text of the agreement is not yet available, a US government briefing document states …
Antiepileptic Drugs, the Developing Nervous System, and the Pregnant Woman With Epilepsy
Authors: Kenneth F. Swaiman
Journal: JAMA (1980)

There have been a number of reports of the teratogenic effects of phenytoin sodium and other antiepileptic drugs on the fetus (p 1464), but scant attention has been given to the possible effects on the developing nervous system. Numerous reports of developmental delay associated with teratogenic effects in both humans and animals exposed to antiepileptic drugs, particularly trimethadione, suggest that the CNS is also adversely affected. The information available is inconclusive; nevertheless, it is a mistake to ignore the continuing clinical and experimental reports of deleterious effects. There are insufficient data available to guide the physician to permit a choice among anticonvulsant drugs for the treatment of pregnant epileptic women, based not only on efficacy but also on safety. The evaluation of the effects of antiepileptic drugs on normal growth and development of nervous tissue is a difficult but necessary task. More research is needed to evaluate the relative safety
Alternative-Pathway Therapy for Hyperammonemia
Authors: Vivian E. Shih
Journal: New England Journal of Medicine (2007)

Ammonia is a toxic compound produced in the body from the catabolism of amino acids and protein. Hyperammonemia can damage muscle and brain.1 The body converts ammonia to urea in the liver by means of the urea-cycle enzymes, and the urea so generated is subsequently eliminated in the urine as nitrogenous waste. This essential process is necessary for the maintenance of health.Metabolic disorders are associated with a defect or deficiency of each of the six enzymes in the urea cycle (Figure 1). These inborn errors of metabolism disrupt the normal processing of ammonia and result in hyperammonemia. In the . . .
INJURY IN ELITE MEN'S LACROSSE: AN OBSERVATIONAL STUDY DURING THE 2010 WORLD CHAMPIONSHIPS
Authors: M Webb, C Davis, D Westacott, R Webb, J Price
Journal: British Journal of Sports Medicine (2013)

There is limited data on injuries sustained while playing men's lacrosse. As the sport gains popularity, practitioners will be more likely to treat lacrosse players. The aim was to gather and analyse injury surveillance data from the 2010 Men's Lacrosse World Championships to recognise potential injury patterns, establish risk of injury, and identify possible means for prevention. This is a prospective observational study of injuries reported during the 2010 Men's Lacrosse World Championships. Data was categorised into Body Part Injured, Diagnosis, Mechanism, and Time of Injury. Over nine days, 29 countries competed in 79 games, with 667 players taking part. A total of 150 injuries were sustained by 129 individuals aged 16 to 46 years old. Five times more injuries were reported to have occurred during games than during training or warm-up sessions (n=104(69%) versus n=20(13%), rate ratio =5.20). An injury rate of 39.5 injuries per 1000 hours played was calculated (95% CI=32.5, 48.0). The most frequent mechanism was contact (n=80, 53%), including direct impact with another player (n=45, 30%), with a stick (n=25, 17%) or ball (n=8, 5%). Change of direction, twisting and sprinting were the most common non-contact mechanisms of injury (n=41, 27%). The most frequently reported injuries were contusions (n=48, 32%), closely followed by sprains (n=34, 23%) and strains (n=34, 23%). The lower limb was the most injured body part, reported twice as often as upper limb injuries (n=76(51%) versus 35(23%), rate ratio =2.17). The ankle was the most commonly injured joint (n=21, 14%) followed by the shoulder (n=15, 10%). As participation in men's lacrosse expands, health professionals could be responsible for treating lacrosse players. The combination of physical play, athleticism and equipment used means players are susceptible to a range of injuries. Familiarity with the sport's common injury-patterns could help in treatment and prevention.
Abstract 4756: YM155 suppresses survivin expression by disrupting the ILF3/p54nrb transcription factor complex
Authors: Naoto Nakamura, Tomohiro Yamauchi, Masashi Hiramoto, Masatoshi Yuri, Masanori Naito, Masahiro Takeuchi, Kentaro Yamanaka, Takahito Nakahara, Aya Kita, Isao Kinoyama, Akira Matsuhisa, Masao Sasamata, Hiroyuki Yokota, Shigeki Kawabata, Kiyoshi Furuichi
Journal: Cancer Research (2012)

Abstract Survivin, a member of the anti-apoptosis proteins family, is highly expressed in all primary tumor types, and is responsible for cancer progression and drug resistance in many types of cancer. YM155, a small chemical compound, selectively suppressed the expression of survivin and induced apoptosis in cancer cells both in vitro and in vivo. However, the mechanisms underlying the suppression of survivin expression by YM155 are unknown. In order to identify the molecular targets and analyze the drug mechanism of action, affinity purification was performed using an active analogue of YM155. We identified interleukin enhancer-binding factor 3 (ILF3) as the binding target of YM155. From the complex analysis of ILF3 and survivin promoter sequence, we also found that ILF3 forms a complex with p54nrb transcription factor, and then binds to the survivin promoter. Overexpression of ILF3 enhanced survivin promoter activity, which was attenuated by YM155 in a concentration-dependent manner. Furthermore, the ILF3/p54nrb complex was disrupted by YM155, thus dispersing the components in the nucleus.In conclusion, our study suggests that binding to ILF3 by YM155 causes the dissociation of the ILF3/p54nrb complex, thus inhibits ILF3 dependent survivin expression. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4756. doi:1538-7445.AM2012-4756
The role of epigenetics in the biology of multiple myeloma
Authors: K Dimopoulos, P Gimsing, K Grønbæk
Journal: Blood Cancer Journal (2014)

Several recent studies have highlighted the biological complexity of multiple myeloma (MM) that arises as a result of several disrupted cancer pathways. Apart from the central role of genetic abnormalities, epigenetic aberrations have also been shown to be important players in the development of MM, and a lot of research during the past decades has focused on the ways DNA methylation, histone modifications and noncoding RNAs contribute to the pathobiology of MM. This has led to, apart from better understanding of the disease biology, the development of epigenetic drugs, such as histone deacetylase inhibitors that are already used in clinical trials in MM with promising results. This review will present the role of epigenetic abnormalities in MM and how these can affect specific pathways, and focus on the potential of novel 'epidrugs' as future treatment modalities for MM.
Acrocyanosis as a heralding sign of ovarian benign teratoma
Authors: P. Neri, A. Messerotti, A. Lonardo, C. Capatti, L. Melini
Journal: American Journal of Hematology (1996)

left ovarion.Following surgical ablation of this tumor (the pathological diagnosis being of ovarian benign teratoma), cryoagglutinins and acrocyanosis disappeared.The patient is well 18 months after surgery.period of 6 weeks.After 2 months she developed malaise and persistent
47Angiogenic potential of human pluripotent stem cell-derived arterial and venous endothelial cells
Authors: E Gara, J Skopal, A Kosztin, B Merkely, SE Harding, G Foldes
Journal: Cardiovascular Research (2014)

Purpose: Endothelial derivatives of human pluripotent stem cells hold out hope for therapeutic angiogenesis. Our aim was to investigate the effect of differentiation protocols on the development of arterial and venous endothelial cells and to study the arterial and venous gene expression pattern after in vivo engraftment of endothelial cells.
Systemic Fat Embolism Following Acute Primary Osteomyelitis
Authors: George Broder
Journal: JAMA (1967)

THE SYNDROME of systemic fat embolism has been recognized for many years and several reviews of the subject have recently been published.1-4The principle underlying etiology is trauma, especially fracture of long bones. There are, however, other much less common predisposing conditions in which the associated fat embolism is usually not recognized. A partial list of these would include severe burns, acute fatty liver of the alcoholic, extracorporeal circulation, corticosteroid therapy, sickle cell and sickle-C crises with bone marrow infarction, following oil lymphography, and pancreatitis.  We wish to report what we believe is the first fully documented case in the American literature of systemic fat embolism following acute primary osteomyelitis.  Report of a Case  A 15-year-old white boy was admitted to the Los Angeles County General Hospital on Aug 13, 1965. There had been a slight headache, some malaise, and left shoulder pain of two to three days duration.
SUN HEAT AND ARTIFICIAL HEAT IN RELATION TO SKIN ERUPTIONS DUE TO LOCAL IRRITANTS
Authors: H. G. ADAMSON
Journal: British Journal of Dermatology (1952)

Journal Article SUN HEAT AND ARTIFICIAL HEAT IN RELATION TO SKIN ERUPTIONS DUE TO LOCAL IRRITANTS Get access H. G. ADAMSON H. G. ADAMSON Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 64, Issue 3, 1 March 1952, Pages 104–105, https://doi.org/10.1111/j.1365-2133.1952.tb16170.x Published: 01 March 1952
Abstract 4048: Aggresome formation is regulated by RanBPM through an interaction with HDAC6.
Authors: Louisa Salemi, Ahmad Almawi, Karen Lefebvre, Caroline Schild Poulter
Journal: Cancer Research (2013)

Abstract RanBPM (Ran-binding protein M, also called RanBP9) is a nucleocytoplamsic protein that has been implicated in a number of cellular processes including cell adhesion, migration and gene transcription. It has been hypothesized to be a scaffolding protein, but its function remains poorly understood. In previous studies we documented the relocalization of RanBPM from the nucleus to the cytoplasm in response to ionizing radiation (IR) treatment. Subsequent analysis showed that IR triggered cytoplasmic RanBPM relocalization in perinuclear dots or foci often located close to an invagination of the nucleus. Upon further investigation, the RanBPM aggregates were identified as aggresomes, which have not been previously documented to occur in response to IR. Aggresomes are aggregates of misfolded/ubiquitinated proteins resulting from improper protein assembly, aberrant modifications and/or environmental stress. These misfolded/ubiquitinated proteins are normally cleared by chaperone-mediated refolding or by proteasomal degradation through the ubiquitin-proteasome system. In conditions where these systems are impaired or overwhelmed, misfolded proteins accumulate in specific perinuclear structures called aggresome. Further analysis confirmed that the RanBPM foci were indeed aggresomes by assessing co-localization of RanBPM with HDAC6, which is required for aggresome formation. Further, we showed RanBPM also formed aggresome in response to treatment with the proteasome inhibitor MG132. To determine the effect of RanBPM downregulation on aggresome formation, we assessed aggresome formation by HDAC6 in RanBPM shRNA and control shRNA Hela and HEK cells. RanBPM downregulation resulted in significantly lower number of aggresomes both after MG132 and IR treatment, suggesting that RanBPM is essential in aggresome formation. Confocal microscopy analysis showed that RanBPM and HDAC6 co-localize within the aggresome and co-immunoprecipitation studies detected an interaction between the two proteins. Downregulation of RanBPM also resulted in decreased acetylated α-tubulin, suggesting that RanBPM regulates HDAC6 activity. Altogether these results suggest that RanBPM may regulate aggresome formation through an interaction with HDAC6. The molecular details of this regulation are currently under investigation. Citation Format: Louisa Salemi, Ahmad Almawi, Karen Lefebvre, Caroline Schild Poulter. Aggresome formation is regulated by RanBPM through an interaction with HDAC6. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4048. doi:10.1158/1538-7445.AM2013-4048
Regional Ileitis in Mother and Son
Authors: G. E. Heard, E. L. John
Journal: BMJ (1956)

Regional Ileitis in Mother and SonA familial incidence of regional ileitis is recognized (Crohn, 1949).We have been able to find reports of 18 instances.Five of these were recorded by Crohn (1949) from his series of 298 cases of the disease.Armitage and Wilson (1950), in their series of 34 patients, noted a single familial case.In nine of the descriptions brothers and/or sisters were affected (Lewisohn, 1938; Brown and Scheifley, 1939: Edwards, 1948; Riech, quoted by Kirsner et al., 1948; Crohn, 1949; Armitage and Wilson, 1950).In a recent com- munication (Crohn and Janowitz, 1954) an additional six in- stances (making a total experience of 11) of familial inci- dence are recorded, but the relationships are not described.Of the remaining three, the patients were first cousins (Bockus, 1943); a child and her two aunts (Crohn, 1949); and a father and son (Kirsner et al., 1948).We present here an acute regional ileitis occurring in the son of a woman suffering from the chronic disease.
Basal Ganglia Infarction Demonstrated by Radionuclide Brain Imaging
Authors: E EDMUND KIM, RICHARD A. SCHACHT, PEGGY A. DOMSTAD, FRANK H. DeLAND
Journal: Clinical Nuclear Medicine (1982)

Four cases of basal ganglia infarction demonstrated by radionuclide brain imaging are presented. Bilateral basal ganglia infarctions in two patients were probably related to methanol intoxication and meningoencephalitis, and unilateral basal ganglia infarctions in two other patients were presumably due to cerebral atherosclerosis and/or hypertension. Various causes and mechanisms of basal ganglia infarction as well as positive findings of radionuclide brain imaging are briefly reviewed.
Letter: Meningococcal prophylaxis
Authors: T. C. Eickhoff
Journal: JAMA (1975)

<h3>To the Editor.—</h3> In his recent COMMENTARY (231:1035, 1975), Dr Artenstein has defined the dilemma confronting clinicians in protecting family contacts of a patient with meningococcal disease against their documented increased risk of secondary cases.<sup>1</sup>I am disturbed, however, by the resolution he has proposed, which states simply that family contacts of patients whose illness is known to be due to sulfonamide-susceptible meningococci be given sulfonamide chemoprophylaxis. Family contacts of patients whose illness is known to be caused by sulfonamide-resistant organisms or in which the sulfonamide resistance of the infecting strain is not known should not be given chemoprophylaxis, but, rather, observed closely, hospitalized, and treated at the first sign of an illness consistent with meningococcemia or meningococcal meningitis. Two new agents, minocycline and rifampin, have proved effective in eliminating meningococci from the nasopharynx of asymptomatic carriers, and it is appropriate to examine each of these more closely. Minocycline
Diagnosing Infertility: Who Is Qualified?
Authors: John T. Armstrong
Journal: JAMA (1993)

<h3>To the Editor.</h3> —I read with shock and dismay the recent summary article regarding obstetrics and gynecology in<i>JAMA</i>'s Contempo issue, 1992.<sup>1</sup> I agree with the statement that "[e]ducation of the consumer can go a long way toward assuring credibility, accountability, and quality" in the care of patients with fertility problems. However, the statement, "[e]ducation of consumers could potentially assure that those having infertility problems would consult only with a physician subspecialist certified in reproductive endocrinology; that those requiring surgery would consult with a member of the Society of Reproductive Surgeons; and that those requiring assisted reproductive technologies would seek care only at centers staffed by members of the Society of Assisted Reproductive Technology," seems truly to take the cart before the horse. I think most "experts" in the field would agree that one first starts an infertility workup and addresses problems in this area with someone trained
P574The association between inflammatory mediator gene markers and cardiovascular disease
Authors: Y Timasheva, T Nasibullin, R Sadikova, G Tulyakova, O Mustafina
Journal: Cardiovascular Research (2014)

Chronic persistent low-grade inflammation is considered a key mechanism contributing to the development of age-related cardiovascular disease. It is hypothesized that the changes happening in cardiovascular system during the process of aging are caused by the imbalance between pro- and anti-inflammatory systems. The aim of the current study was to investigate an association between inflammatory mediator gene markers and cardiovascular phenotypes (essential ypertension, myocardial infarction, sudden cardiac death).
Varieties of self-deception
Authors: Robert F. Bornstein
Journal: Behavioral and Brain Sciences (1997)

Mele's analysis of self-deception is persuasive but it might also be useful to consider the varieties of self-deception that occur in real-world settings. Instances of self-deception can be classified along three dimensions: implicit versus explicit, motivated versus process-based, and public versus private. All three types of self-deception have implications for the scientific research enterprise.
Radioisotope Detection of Ocular Melanomas
Authors: Thomas J. Walsh, Samuel Packer
Journal: New England Journal of Medicine (1971)

RECENTLY, Beierwaltes and his associates1 described three patients in whom they used a new radioisotope analogue of ehloroquine, 125I NM-113,† for the detection of malignant skin melanomas. Their results for detecting the extent of the lesion as well as for scanning for nodal metastasis are extremely promising. It is thought that 125I NM-113 might be useful in detecting choroidal melanomas, in differentiating other pigmented lesions and in evaluating a blind, painful eye with opaque medium for the presence of tumor. The purpose of this communication is to present the results in three patients with primary ocular melanoma in whom this . . .
735-4 Characteristics of Patent Foramen Ovale in Stroke Patients: Two-dimensional and Biplane Contrast Transesophageal Study
Authors: Stefano De Castro, Domenico Cartoni, Sergio Beni, Monica Moschini Antinori, Francesco Pelliccia, Paride Giannantoni, Maurizia Rasura, Alexia Anzini
Journal: Journal of the American College of Cardiology (1995)
World Bank provides $2.4bn to pay mothers to take their babies to health clinics
Authors: B. Bland
Journal: BMJ (2009)

The World Bank will lend $2.4bn (£1.7bn; €1.9bn) to developing countries this year to support the expansion of schemes in which mothers receive money in exchange for committing to take their babies to health clinics regularly or ensuring that their children stay in school.

With the deepening economic problems expected to push many families worldwide below the poverty line, the bank believes that targeted cash payments can help to provide a short term safety net and improve health and education in the longer term.

In a report into the …
Depression should be managed like a chronic disease: What exactly is “depression”?
Authors: Derek A Summerfield
Journal: BMJ (2006)

EDITOR—Scott implies that depression is always a timeless, free-standing, internally coherent, universally valid, pathological entity with a life of its own out there.1 Classification systems (generally called international but in fact merely Western) provide definitions which seem to assume this. However, disclaimers in small print say in effect that diagnostic categories are not facts of nature …
Effect of the Neighborhood Health Center on the Use of Pediatric Emergency Departments in Rochester, New York
Authors: Louis I. Hochheiser, Kenneth Woodward, Evan Charney
Journal: New England Journal of Medicine (1971)

Abstract Neighborhood health centers can be an important new development in medical care for indigents in a metropolitan community. The effectiveness of one of these centers in reducing the number of pediatric visits to emergency departments was studied by comparison of the number of emergency-department visits by Health Center area children in 1967, before the Center opened, with the number of visits by Center-area children in 1969 and 1970, nine and 21 months after the Health Center was established. The changes were compared with other child populations in areas lacking health centers. There was a 38 per cent reduction in child visits in the Health Center area to emergency departments from 1967 to 1970. In contrast, there was no change in the number of pediatric emergency-department visits from the rest of the city and a 29 per cent increase in emergency-department visits by suburban children.