New Modes of Insulin Administration: Do They Have a Role in Clinical Diabetes?
Authors: ROBERT A. RIZZA
Journal: Annals of Internal Medicine (1986)

Editorials1 July 1986New Modes of Insulin Administration: Do They Have a Role in Clinical Diabetes?ROBERT A. RIZZA, M.D.ROBERT A. RIZZA, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-105-1-126 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe availability of insulin in the 1920s dramatically changed the treatment of diabetes mellitus. Life was prolonged for patients and their well-being was at least temporarily restored. Unfortunately, subsequent progress has been slow. Our ability to alter the appearance and progression of the chronic microvascular and macrovascular complications of diabetes has changed little, if any, over the last 50 years. Physicians and patients have long hoped that the chronic complications of diabetes could be averted if blood glucose concentrations could be maintained in the nondiabetic range. Until recently, testing this "glucose hypothesis" was virtually impossible, because maintenance of euglycemia in...References1. SLAMAHAUTECOUVERTUREASSANTCHOBROUTSKY GMRG. One to five days of continuous intravenous insulin infusion on seven diabetic patients. Diabetes. 1974;23:732-8. CrossrefMedlineGoogle Scholar2. GENUTHMARTIN SP. Control of hyperglycemia in adult diabetics by pulsed insulin delivery. Diabetes. 1977;26:571-81. CrossrefMedlineGoogle Scholar3. DECKERTLORUP TB. Regulation of brittle diabetics by a pre-planned insulin infusion programme. Diabetologia. 1976;12:573-9. CrossrefMedlineGoogle Scholar4. SERVICE F. Normalization of plasma glucose of unstable diabetes: studies under ambulatory, fed conditions with pumped intravenous insulin. J Lab Clin Med. 1978;91:480-9. MedlineGoogle Scholar5. ALBISSERLIEBELEWART ABT. Clinical control of diabetes by the artificial pancreas. Diabetes. 1974;23:397-404. CrossrefMedlineGoogle Scholar6. KERNERTHUMTAMASBEISCHERCLEMENSPFEIFFER WCGWAE. Attempts at perfect normalization of glucose tolerance test of severe diabetics by the artificial beta cell. Horm Metab Res. 1976;8:256-61. CrossrefMedlineGoogle Scholar7. SANTIAGOCLEMENSCLARKEKIPNIS JAWD. Close-loop and open-loop devices for blood glucose control in normal and diabetic subjects. Diabetes. 1979;28:71-84. CrossrefMedlineGoogle Scholar8. PICKUPKEENPARSONSALBERTI JHJK. Continuous subcutaneous insulin infusion: an approach to achieving normoglycaemia. Brit Med J. 1978;1:204-7. CrossrefMedlineGoogle Scholar9. TAMBORLANESHERWINGENELFELIG WRMP. Reduction to normal of plasma glucose in juvenile diabetes by subcutaneous administration of insulin with a portable infusion pump. N Engl J Med. 1979;300:573-8. CrossrefMedlineGoogle Scholar10. SCHADESANTIAGOSKYLERRIZZA DJJR. Intensive Insulin Therapy. Amsterdam: Excerpta Medica; 1983. Google Scholar11. MECKLENBURGBENSONBENSON REJ. Long-term metabolic control with insulin pump therapy: report of experience with 27 patients. N Engl J Med. 1985;313:465-8. CrossrefMedlineGoogle Scholar12. DEEBWILLIAMS LP. Surveillance in Florida of continuous subcutaneous insulin infusion use in a cohort. Diabetes Care. (In press). Google Scholar13. PIETRIRASKIN AP. Cutaneous complications of chronic continuous subcutaneous insulin infusion therapy. Diabetes Care. 1981;4:624-6. CrossrefMedlineGoogle Scholar14. RIZZAGERICHHAYMOND RJM. Control of blood sugar in insulin-dependent diabetes: comparison of an artificial endocrine pancreas, continuous subcutaneous insulin infusion, and intensified conventional insulin therapy. N Engl J Med. 1980;303:1313-8. CrossrefMedlineGoogle Scholar15. SCHIFFRINBELMONTE AM. Comparison between continuous subcutaneous insulin infusion and multiple injections of insulin: a one-year prospective study. Diabetes. 1982;31:255-64. CrossrefMedlineGoogle Scholar16. REEVESSEIGLERRYANSKYLER MDEJ. Glycemic control in insulin-dependent diabetes mellitus: comparison of outpatient intensified conventional therapy with continuous subcutaneous insulin infusion. Am J Med. 1982;72:673-80. CrossrefMedlineGoogle Scholar17. IRSIGLERKRITZ KH. Long-term continuous intravenous insulin therapy with a portable insulin dosage-regulating apparatus. Diabetes. 1979;28:196-203. CrossrefMedlineGoogle Scholar18. PERLMANEHRLICHFILLERALBISSER KRRA. Waveform requirements for metabolic normalization with continuous intravenous insulin delivery in man. Diabetes. 1981;30:710-7. CrossrefMedlineGoogle Scholar19. SCHADEEATONDAVIS DRT. The kinetics of peritoneal insulin absorption. Metabolism. 1981;30:149-55. CrossrefMedlineGoogle Scholar20. SELAMSLINGENEYERHEDONMARESBERAUDMIROUZE JABPJJ. Long-term ambulatory peritoneal insulin infusion of brittle diabetes with portable pumps: comparison with intravenous and subcutaneous routes. Diabetes Care. 1983;6:105-11. CrossrefMedlineGoogle Scholar21. BLACKSHEARRHODEGROTTING PTJ. Control of blood glucose in experimental diabetes by means of a totally implantable insulin infusion device. Diabetes. 1979;28:634-9. CrossrefMedlineGoogle Scholar22. IRSIGLERKRITZHAGMÜLLER KHG. Long-term continuous intraperitoneal insulin infusion with an implanted remote-controlled insulin infusion device. Diabetes. 1981;30:1072-5. CrossrefMedlineGoogle Scholar23. PATELRYMAN HB. Oral administration of insulin by encapsulation within liposomes. FEBS Lett. 1976;62:60-3. CrossrefMedlineGoogle Scholar24. MOSESGORDONCAREYFLIER AGMJ. Insulin administered intranasally as an insulin-bile salt aerosol: effectiveness and reproducibility in normal and diabetic subjects. Diabetes. 1983;32:1040-7. CrossrefMedlineGoogle Scholar25. MECKLENBURGBENSONBENSON REJ. Acute complications associated with insulin pump therapy: report of experience with 161 patients. JAMA. 1984;252:3265-9. CrossrefMedlineGoogle Scholar26. WHITESKORCRYERLEVANDOSKIBIERSANTIAGO NDPLDJ. Identification of type I diabetic patients at increased risks for hypoglycemia during intensive therapy. N Engl J Med. 1983;308:485-91. CrossrefMedlineGoogle Scholar27. SIMONSONTAMBORLANEDEFRONZOSHERWIN DWRR. Intensive insulin therapy reduces counterregulatory hormone responses to hypoglycemia in patients with type I diabetes. Ann Intern Med. 1985;103:184-90. LinkGoogle Scholar28. PICKUPVIBERTIBILOUS JGR. Safety of continuous subcutaneous insulin infusion: metabolic deterioration and glycaemic autoregulation after deliberate cessation of infusion. Diabetologia. 1982;22:175-9. CrossrefMedlineGoogle Scholar29. ALBISSERMCADAMPERLMANCARSONBAHORICWILLIAMSON AKKSAJ. Unanticipated amyloidosis in dogs infused with insulin. Diabetes. 1983;32:1092-101. CrossrefMedlineGoogle Scholar30. MAUERBUCHWALDGROPPOLI SHT. Failure to find amyloidosis in dogs treated with long-term intravenous insulin delivered by a totally implantable pump. Diabetologia. 1983;25:448-50. CrossrefMedlineGoogle Scholar31. BROWNLEEVLASSARACERAMIMARTINLIMCADAM MHJTJK. Association of insulin pump therapy with raised serum amyloid A in type I diabetes mellitus. Lancet. 1984;1:411-3. CrossrefMedlineGoogle Scholar32. BENDINGPICKUPROWE JJI. Continuous subcutaneous insulin infusion does not include a significant acute phase response of serum amyloid A protein. Diabetologia. 1985;28:113-5. MedlineGoogle Scholar33. KOIVISTOTEPPOMAURYTASKINEN VACM. No evidence of amyloidosis in type I diabetics treated with continuous subcutaneous insulin infusion. Diabetes. 1983;32:88-90. CrossrefMedlineGoogle Scholar34. RASKINPIETRIUNGER PAR. Changes in glucagon levels after four to five weeks of glucoregulation by portable insulin infusion pumps. Diabetes. 1979;28:1033-5. CrossrefMedlineGoogle Scholar35. TAMBORLANESHERWINKOIVISTOHENDLERGENELFELIG WRVRMP. Normalization of the growth hormone and catecholamine response to exercise in juvenile-onset diabetic subjects treated with a portable insulin infusion pump. Diabetes. 1979;28:785-8. CrossrefMedlineGoogle Scholar36. MATHIESENHILSTEDFELDT-RASMUSSENBONDE-PETERSENCHRISTENSENPARVING EJBFNH. The effect of metabolic control on hemodynamics in short-term insulin-dependent diabetic patients. Diabetes. 1985;34:1301-5. CrossrefMedlineGoogle Scholar37. WHITEWALTMANKRUPINSANTIAGO NSTJ. Reversal of abnormalities in ocular fluorophotometry in insulin-dependent diabetes after five to nine months of improved metabolic control. Diabetes. 1982;31:80-5. CrossrefMedlineGoogle Scholar38. . Effect of six months of strict metabolic control on eye and kidney function in insulin-dependent diabetics with background retinopathy. Lancet. 1982;1:121-4. MedlineGoogle Scholar39. PUKLINTAMBORLANEFELIGGENELSHERWIN JWPMR. Influence of long-term insulin infusion pump treatment of type I diabetes on diabetic retinopathy. Ophthalmology. 1982;89:735-47. CrossrefMedlineGoogle Scholar40. LAURITZENFROST-LARSENLARSENDECKERT TKHT. Effect of 1 year of near-normal blood glucose levels on retinopathy in insulin-dependent diabetics. Lancet. 1983;1:200-4. CrossrefMedlineGoogle Scholar41. . Blood glucose control and the evolution of diabetic retinopathy and albuminuria: a preliminary multicenter trial. N Engl J Med. 1984;311:365-72. CrossrefMedlineGoogle Scholar42. BRINCHMANN-HANSENDAHL-JORGENSENHANSSENSANDVIK OKKL. Effects of intensified insulin treatment on various lesions of diabetic retinopathy. Am J Ophthalmol. 1985;100:644-53. CrossrefMedlineGoogle Scholar43. VIBERTIBILOUSMACKINTOSHBENDINGKEEN GRDJH. Long term correction of hyperglycaemia and progression of renal failure in insulin dependent diabetes. Br Med J [Clin Res]. 1983;286:598-602. CrossrefMedlineGoogle Scholar44. VIBERTIPICKUPJARRETTKEEN GJRH. Effect of control of blood glucose on urinary excretion of albumin and β2 microglobulin in insulin-dependent diabetes. N Engl J Med. 1979;300:638-41. CrossrefMedlineGoogle Scholar45. WISEMANSAUNDERSKEENVIBERTI MAHG. Effect of blood glucose control on increased glomerular filtration rate and kidney size in insulin-dependent diabetes. N Engl J Med. 1985;312:617-21. CrossrefMedlineGoogle Scholar46. FELDT-RASMUSSENMATHIESENHEGEDÜSDECKERT BELT. Kidney function during 12 months of strict metabolic control in insulin-dependent diabetic patients with incipient nephropathy. N Engl J Med. 1986;314:665-70. CrossrefMedlineGoogle Scholar47. PIETRIEHLERASKIN AAP. Changes in nerve conduction velocity after six weeks of glucoregulation with portable insulin infusion pumps. Diabetes. 1980;29:668-71. CrossrefMedlineGoogle Scholar48. GRAFHALTERPFEIFERHALARBROZOVICHPORTE RJMEFD. Glycemic control and nerve conduction abnormalities in non-insulin-dependent diabetic subjects. Ann Intern Med. 1981;94:307-11. LinkGoogle Scholar49. SERVICERIZZADAUBEO'BRIENDYCK FRJPP. Near normoglycaemia improved nerve conduction and vibration sensation in diabetic neuropathy. Diabetologia. 1985;28:722-7. MedlineGoogle Scholar50. PETERSONJONESESTERLYWARTZJACKSON CRJGR. Changes in basement membrane thickening and pulse volume concomitant with improved glucose control and exercise in patients with insulindiabetes mellitus. Diabetes Care. 1980;3:586-9. CrossrefMedlineGoogle Scholar51. RASKINPIETRIUNGERSHANNON PARW. The effect of diabetic control on the width of skeletal-muscle capillary basement membrane in patients with type I diabetes mellitus. N Engl J Med. 1983;309:1546-50. CrossrefMedlineGoogle Scholar52. DECKERTEGEBERGFRIMODT-MOLLERSANDERSVEJGAARD TJCEA. Basement membrane thickness, insulin antibodies and HLA-antigens in long standing insulin dependent diabetics with and without severe retinopathy. Diabetologia. 1979;17:91-6. CrossrefMedlineGoogle Scholar53. DUNNDONALDDAYSTEWARTSTEWART PRTJA. The association between diabetic retinopathy and skeletal muscle capillary basal lamina thickening corrected for the influence of age and duration of diabetes. Diabetes. 1979;28:858-64. CrossrefMedlineGoogle Scholar54. STEFFESSUTHERLANDGOETZRICHMAUER MDFSS. Studies of kidney and muscle biopsy specimens from identical twins discordant for type I diabetes mellitus. N Engl J Med. 1985;312:1282-7. CrossrefMedlineGoogle Scholar55. DUNNPIETRIRASKIN FAP. Plasma lipid and lipoprotein levels with continuous subcutaneous insulin infusion in type I diabetes mellitus. Ann Intern Med. 1981;95:426-31. LinkGoogle Scholar56. STOUT R. The role of insulin in atherosclerosis in diabetics and nondiabetics: a review. Diabetes. 1981;30(suppl 2):54-7. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROBERT A. RIZZA, M.D.Affiliations: Mayo Clinic, Rochester, Minnesota PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySelf-monitoring of blood glucose and insulin dose alteration in type 1 diabetes mellitusDiabetes mellitus and the surgeonNew Modes of Insulin AdministrationGRANT GWINUP, M.D. 1 July 1986Volume 105, Issue 1Page: 126-129KeywordsAttentionBloodDiabetes mellitusGlucoseInsulin ePublished: 1 December 2008 Issue Published: 1 July 1986 PDF downloadLoading ...