tbuckley/cabot-search huggingface dataset:
Editor in the eye of a storm
Authors: Joanna Lyall
Journal: BMJ (2004)

Is the editor of a medical journal responsible for the way its contents are reported, and the quality of the ensuing debate, as well as the accuracy of the material itself? It is a question that Dr Richard Horton, editor of the Lancet , and one of the figures in the eye of this week's media storm over the MMR (measles, mumps, and rubella) vaccine, has answered unequivocally in the past.

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The Sunday Times article that sparked the latest MMR controversy

In an essay entitled “Vaccine Myths”—included in his book Doctors, Diseases and Decisions in Modern Medicine , which was published last year (reviewed BMJ 2003;327: 399)—Dr Horton recounted the events that followed the Lancet 's publication of Dr Andrew Wakefield's 1998 study that sparked the suggestion of a link between MMR and autism. He says: “Although I knew this paper would be controversial, I did not expect the level of vituperative attack and personal rebuke that followed. I was terribly and, looking back now, embarrassingly naive. I should have met with the Royal Free team before they held their press conference. I should have at …

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Beta-adrenergic modulation of fast inward sodium current in canine myocardium. Syncytial preparations versus isolated myocytes.
Authors: G A Gintant, D W Liu
Journal: Circulation Research (1992)

Reports have suggested that the fast inward sodium current (INa) in cardiac tissues may be modulated by beta-adrenergic stimulation and that such modulation may affect conduction in the setting of myocardial ischemia and infarction. However, many of these studies have used dissociated myocytes or broken cell preparations, whose responses need not necessarily reflect those of syncytial preparations. To investigate further the possibility that beta-adrenergic stimulation of INa may differ in various preparations, we compared the effects of the beta-agonist isoproterenol (ISO) on syncytial canine Purkinje fibers and ventricular muscle preparations, as well as isolated ventricular myocytes. Alterations of the maximum rate of rise of the action potential upstroke (Vmax) were used as an index of changes of INa. ISO (1 microM) had no effect on Vmax of upstrokes of normally polarized (fast responses) or partially depolarized (elevated [K+]o, depressed fast responses) syncytial ventricular muscle preparations or Purkinje fibers. In contrast, lower concentrations of ISO (0.5-1.0 microM) modulated Vmax of isolated ventricular myocytes, depending on the technique used to monitor transmembrane potential. When 2.7 M KCl-filled microelectrodes were used, ISO reduced Vmax of partially depolarized myocytes without affecting Vmax of normally polarized myocytes. However, when myocytes were dialyzed using patch pipettes, ISO reduced Vmax of partially depolarized myocytes and increased Vmax of normally polarized myocytes, effecting a hyperpolarized shift of the normalized inactivation curve relating Vmax to resting membrane potential. The different beta-adrenergic responses of syncytial preparations and nondialyzed and dialyzed myocytes suggest that differences in the ionic or metabolic condition of the preparations likely alter cAMP-dependent responses and channel phosphorylation.(ABSTRACT TRUNCATED AT 250 WORDS)
Minerva might help you get something published
Authors: Eoin P O'Sullivan, Una O'Colmain
Journal: BMJ (2006)

Editor-The report from the chief medical officer for England has implications for all UK doctors and needs to be considered very carefully. 1Its aim is a system of medical regulation that puts patients' safety first through the early detection, and where possible, remediation, of poor performance.If the report contributes to that aim, and commands public and professional support, it should be welcomed by everyone involved in health care.The Merrison report was the collective effort of Sir William Merrison and the other 14 members of his committee of inquiry, who took both oral and written evidence. 2A different process has been followed in this case.The government, sensibly, has therefore decided on a period of consultation during which the recommendations can be properly debated, tested, and costed.We have already said that we believe that the recommendations to divorce oversight of medical education from the other regulatory functions of standards, registration, and fitness to practise are not in patients' best interests.We will now be consulting widely with our partners before we submit our considered response.It may be another 30 years before there is another opportunity such as this.We must seize it so that future generations of patients can say that we did not fail them.
The Association Of Spirometry With Asthma Control and Asthma Morbidity In Inner City Schoolchildren With Asthma
Authors: Watcharoot Kanchongkittiphon, Jonathan M. Gaffin, Lianne S. Kopel, William J. Sheehan, Sachin N. Baxi, Perdita Permaul, Diane R. Gold, Wanda Phipatanakul
Journal: Journal of Allergy and Clinical Immunology (2014)
Nonsmokers' Rights Go International
Authors: Phil Gunby
Journal: JAMA (1989)

THE UNITED NATIONS' World Health Organization (WHO), as part of a campaign against tobacco, is expected early in this new year to circulate a statement of nonsmokers' rights to health officials from a number of nations, especially in Europe. Among other things, the statement emphasizes the right to be free from breathing tobacco smoke in enclosed public places and the need for continued public education on the health consequences of tobacco use. The statement was worked out at the first European Conference on Tobacco Policy, cosponsored by the Switzerland-based WHO and Spain's Ministry of Health and Consumer Affairs. That multinational conference, held in Madrid in November, resulted in health officials from six European countries indicating that their governments probably will adopt the statement. The Madrid conference was held on the eve of the 12th annual Great American Smokeout, sponsored in the United States by the American Cancer Society and intended
Short-term granulocyte colony-stimulating factor and erythropoietin treatment enhances hematopoiesis and survival in the mitomycin C–conditioned Fancc−/− mouse model, while long-term treatment is ineffective
Authors: Madeleine Carreau, Lili Liu, Olga I. Gan, Johann K. Hitzler, John E. Dick, Manuel Buchwald
Journal: Blood (2002)
Peripheral blood and intestinal lymphocyte sub-populations in Crohn's disease.
Authors: R G Strickland, G Husby, W C Black, R C Williams
Journal: Gut (1975)

Immunofluorescent technques were utilized to study the nature and distribution of cells forming the inflammatory infiltrate in Crohn9s disease. Tissue from resected ileum (one patient) or colon (one patient) when compared with corresponding control tissues contained increased numbers of B and T lymphocytes. B-cells of IgG class predominated in the mucosal lamina propria, whereas T-cells were prominent in the deeper layers of inflamed bowel. Inflammatory cells bearing Fc receptors were also present in these tissues. Decreased peripheral blood T-cell numbers returned to normal after resection of the involved bowel in the two patients studied. Impaired cellular immunity in Crohn9s disease may thus result from T-cell sequestration in or loss from involved segments of intestine.
ABC of emergency radiology. Chest radiographs--II.
Authors: D W Hodgkinson, B R O'Driscoll, P A Driscoll, D A Nicholson
Journal: BMJ (1993)

The common conditions seen in the accident and emergency department that require chest radiography can be divided into two types-those resulting from trauma and those from other causes. TraumaInjuries associated with blunt thoracic trauma Possible associated Mechanism Chest wall injury intrathoracic injury Low energy transfer Unilateral rib fracture Pulmonary (direct blow) Anterior sternal fracture contusion Cardiac contusion High energy transfer Chest wall may be intact Ruptured aorta (deceleration) Cardiac contusion Bilateral rib fracture Ruptured diaphragm Sternal fracture Ruptured bronchus Crush injury Bilateral rib fractures with or Ruptured bronchus without flail chest Cardiac contusion Ipsilateral rib fractures with or Pulmonary without flail chest contusion Possible contralateral internal rib fracture
Defective Lentiviral Vectors Are Efficiently Trafficked by HIV-1 and Inhibit Its Replication
Authors: Ekaterina Klimatcheva, Vicente Planelles, Shannon L. Day, Frank Fulreader, Matthew J. Renda, Joseph Rosenblatt
Journal: Molecular Therapy (2001)

Gene therapy against HIV infection should involve vector-mediated delivery of anti-HIV therapeutic genes into T-lymphocytes and macrophages or, alternatively, hematopoietic progenitors. Transduction of mature cells with defective vectors would have limited success because the vector would disappear with cell turnover. However, if a vector could be trafficked by wild-type HIV, initial transduction of a majority of the population would not be required, as the vector would be able to spread. We describe HIV-1-based lentiviral vectors that are efficiently packaged and trafficked by HIV-1, allowing a small number of cells initially transduced to spread the vector within a nontransduced cell population. We examined whether the presence or absence of the rev gene and the Rev-responsive element (RRE) would have a noticeable effect on the ability of lentiviral vectors to be trafficked and to inhibit HIV-1 replication. We found that replacement of rev/RRE with a constitutive transport element from Mason-Pfizer monkey virus had no apparent effect on trafficking and did not change the intrinsic inhibitory abilities of the vectors. We also constructed a rev/RRE-independent HIV-1-derived vector carrying a trans-dominant negative mutant of HIV-1 Rev, RevM10. This vector was less efficiently trafficked by HIV-1 and, despite the presence of an anti-HIV-1 gene, RevM10, was less efficient at inhibiting HIV-1 replication when introduced into a target T-cell population.
Reduction of Atrial Defibrillation Threshold With an Interatrial Septal Electrode
Authors: Xiangsheng Zheng, Michael E. Benser, Gregory P. Walcott, Steven D. Girouard, Dennis L. Rollins, William M. Smith, Raymond E. Ideker
Journal: Circulation (2000)

Background —The standard lead configuration for internal atrial defibrillation consists of a shock between electrodes in the right atrial appendage (RAA) and coronary sinus (CS). We tested the hypothesis that the atrial defibrillation threshold (ADFT) of this RAA→CS configuration would be lowered with use of an additional electrode at the atrial septum (SP). Methods and Results —Sustained atrial fibrillation was induced in 8 closed-chest sheep with burst pacing and continuous pericardial infusion of acetyl-β-methylcholine. Defibrillation electrodes were situated in the RAA, CS, pulmonary artery (PA), low right atrium (LRA), and across the SP. ADFTs of RAA→CS and 4 other lead configurations were determined in random order by use of a multiple-reversal protocol. Biphasic waveforms of 3/1-ms duration were used for all single and sequential shocks. The ADFT delivered energies for the single-shock configurations were 1.27±0.67 J for RAA→CS and 0.86±0.59 J for RAA+CS→SP; the ADFTs for the sequential-shock configurations were 0.39±0.18 J for RAA→SP/CS→SP, 1.16±0.72 J for CS→SP/RAA→SP, and 0.68±0.46 J for RAA→CS/LRA→PA. Except for CS→SP/RAA→SP versus RAA→CS and RAA→CS/LRA→PA versus RAA+CS→SP, the ADFT delivered energies of all of the configurations were significantly different from each other ( P &lt;0.05). Conclusions —The ADFT of the standard RAA→CS configuration is markedly reduced with an additional electrode at the atrial SP.
Mitomycin C Therapy in Advanced Gastrointestinal Cancer
Authors: Charles G. Moertel
Journal: JAMA (1968)

Mitomycin C (NSC-26980) is a chemotherapeutic agent capable of producing objective regressions in gastrointestinal cancer at a rate approximately comparable to that of the fluorinated pyrimidines. It can be administered intravenously, with clinically tolerable toxicity, either by prolonged, low-dosage schedule or by a short, intensive course. The latter method presents fewer practical problems. The brief duration of tumor regressions obtained, the hazard of infiltration ulcers, and the compounding of toxicity with repeated treatment are factors which seriously limit the usefulness of the agent, however, and it cannot be recommended for routine clinical use.
SENSITIVITY TO WAR GASES
Authors: Edward F. Lewison
Journal: JAMA (1942)

<h3>To the Editor:—</h3> I read with keen interest a communication toThe Journal, Nov. 29, 1941, page 1879, by Frank B. Queen, M.D., Major, M. C., U. S. Army, and Tom Stander, M.D., Major, M. C., U. S. Army, in which they report a case of severe generalized hypersensitivity to tear gas (CN) considered to be idiopathic. "Of particular interest in the case is the fact that once before the patient had, on transient exposure by passing through a cloud of tear gas during a course of instruction while in the National Guard, experienced itching of the skin which, though remembered seventeen years after the event, was not incapacitating." Here at Edgewood Arsenal, the center of the Chemical Warfare Service, we have observed that all persons are sensitive to chemical agents when exposed to their effect for the first time. A certain degree of individual variation in sensitivity does occur
IPH2101, a novel anti-inhibitory KIR antibody, and lenalidomide combine to enhance the natural killer cell versus multiple myeloma effect
Authors: Don M. Benson, Courtney E. Bakan, Shuhong Zhang, Shauna M. Collins, Jing Liang, Shivani Srivastava, Craig C. Hofmeister, Yvonne Efebera, Pascale Andre, Francois Romagne, Mathieu Bléry, Cécile Bonnafous, Jianying Zhang, David Clever, Michael A. Caligiuri, Sherif S. Farag
Journal: Blood (2011)
And It Does No Good to Scratch
Authors: R. A. Moss
Journal: JAMA (1975)

<h3>To the Editor.—</h3> The following is excerpted from the minutes of a staff meeting at the Central Michigan Community Hospital: Several members of the staff expressed their views in a pointed fashion as regards the unremitting spread of bureaucratic interference with the practice of medicine. These remarks seemed to imply that one could draw certain analogies between bureaucrats and an organism known officially as<i>Sarcoptes scabei</i>. A. Both tend to be associated with mental, physical, and moral decadence. B. Both abound where long hair and poor personal hygiene are prevalent. C. Both tend to get under the skin. D. Both have amazing powers of proliferation. E. The modus operandi is similar, consisting of infiltration, occupation, and procreation. F. In contrast to symbiotic relationships, the host benefits from neither. On the other hand, it occurs to this reporter that there are certain differences worthy of note: A. Whereas<i>Sarcoptes</i>is extremely
Distribution of polyamines in human epidermis
Authors: P. BAZE, G. MILANO, P. VERRANDO, N. RENEE, J.P. ORTONNE
Journal: British Journal of Dermatology (1985)

Consecutive sections through the epidermis were cut parallel to its surface, and the polyamine (PA) concentration in each section was measured by liquid chromatography. There was a constant decrease in PA concentration (expressed as nmol/mg DNA) from the deepest layer to the more superficial layers. Putrescine showed the greatest increase (+83%) (P less than 0.02). The elevations of spermidine and spermine levels were less marked, respectively +30% (P less than 0.05) and +27% (NS). Proliferating cells in the basal layer possess high polyamine levels and as they mature in the superficial layers their polyamine content decreases.
Science Writers, Physicians, and the Public—Ménage à Trois
Authors: IRVINE H. PAGE
Journal: Annals of Internal Medicine (1970)

The news media have become important in the affairs of both medicine and science. Thoughtful formulation of policy in connection with them is overdue if serious ethical and moral problems are to be anticipated. The problem is delineated in several important aspects, such as celebrity building, the press' right to know, the importance of prestige, and priorities. The established mechanisms of communication and some weaknesses and strengths are considered, and some suggestions for improvement are made.
Association Between Age at Diagnosis and the Presence of EGFR Mutations in Female Patients with Resected Non-small Cell Lung Cancer
Authors: Yoon Hee Choi, Jin Kyung Lee, Hye Jin Kang, Tae Sup Lee, Hye-Ryoun Kim, Cheol Hyeon Kim, Jae Soo Koh, Hee Jong Baek, Jae Cheol Lee, Im Il Na
Journal: Journal of Thoracic Oncology (2010)
Platelet hyperaggregability in a patient with Klinefelter's syndrome and leg ulcers
Authors: P.G. NORRIS, J.K. RIVERS, S. MACHIN, P.M. DOWD, W.A.D. GRIFFITHS
Journal: British Journal of Dermatology (1987)

We describe a patient with Klinefelter's syndrome complicated by recalcitrant leg ulcers, in whom marked platelet hyperaggregability was demonstrated and venous disease excluded. Androgen replacement therapy appeared to bring about healing of the patient's ulcers and was associated with reversal of the platelet abnormality. The possible role of androgen deficiency in the pathogenesis of leg ulceration is discussed.
A Piece of my mind. Sunday rounds
Authors: J. L. Wright
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PREVENTION OF TUBERCULOSIS BY MEANS OF TUBERCULIN
Authors: R. Carswell
Journal: BMJ (1930)

TUBERCULOSIS BY TUBERCULI'.[NaIu 9 '5snprarenal medulla.Since it is in this ti .suethat the pirod-in.tion of adrenlaliine takes place, it seemils Inot unlikely tha.t hyperaldrenalismii may be an associated factor in hyper- tension, and that its existeiice iimay be refected.in tlhe high amino-acid content.This rel-ationship is to be the suLibject of futrither investigation.
Perforation of the Colon in a Neonate Who Recovered
Authors: Richard Sabransky
Journal: JAMA (1961)

THELANDER<sup>1</sup>in 1939 published a classic review of perforation of the gastrointestinal tract in newborn infants. He reviewed the literature written between 1825 and 1939 and discovered 23 cases of perforated colon. The first patient to survive was reported by Lee and MacMillan in 1950.<sup>2</sup>Their infant had an atresia of the transverse colon proximal to the splenic flexure. Standard in 1952<sup>3</sup>reported the second case of a colon perforation in a patient who survived. The rectosigmoid was perforated, and no etiology could be established. Roseman in 1958<sup>4</sup>reported the third patient to have recovered from a neonatal colon perforation. The infant was 11 days old, and a walled-off abscess was found at the site of perforation. It is apparent that perforation of the colon in the newborn infant is a very infrequent occurrence and that recovery, as recorded in the medical literature, is rare. The
Surgical Management of Neonatal Jaundice
Authors: Alfred A. DeLorimier
Journal: New England Journal of Medicine (1973)

PERSISTENT obstructive jaundice in infants presents a diagnostic and therapeutic challenge. Several forms of biliary-duct obstruction, such as biliary atresia, choledochal cyst or inspissated bile syndrome, require surgical repair. Almost 1/2 of all infants with prolonged jaundice have cholestasis of nonsurgical origin. Cholestasis developing in the first few months of life may be caused by neonatal hepatitis, intrahepatic biliary atresia, toxoplasmosis, cytomegalic inclusion disease, rubella, herpes simplex, coxsackie virus, syphilis and metabolic diseases such as galactosemia. Neonatal hepatitis accounts for 85 to 90 per cent of the nonsurgical types of jaundice.The causes of neonatal hepatitis and biliary atresia are . . .
An expanding role for primary care providers in the treatment of hepatitis C virus infection in the community
Authors: Jason Grebely, Gregory J. Dore, Kris Kowdley, Geoffrey McCaughan, Christian Trautwein
Journal: Hepatology (2010)

The Extension for Community Healthcare Outcomes (ECHO) model was developed to improve access to care for underserved populations with complex health problems such as hepatitis C virus (HCV) infection. With the use of video-conferencing technology, the ECHO program trains primary care providers to treat complex diseases. We conducted a prospective cohort study comparing treatment for HCV infection at the University of New Mexico (UNM) HCV clinic with treatment by primary care clinicians at 21 ECHO sites in rural areas and prisons in New Mexico. A total of 407 patients with chronic HCV infection who had received no previous treatment for the infection were enrolled. The primary end point was a sustained virologic response. A total of 57.5% of the patients treated at the UNM HCV clinic (84 of 146 patients) and 58.2% of those treated at ECHO sites (152 of 261 patients) had a sustained viral response (difference in rates between sites, 0.7 percentage points; 95% confidence interval, −9.2 to 10.7; P = 0.89). Among patients with HCV genotype 1 infection, the rate of sustained viral response was 45.8% (38 of 83 patients) at the UNM HCV clinic and 49.7% (73 of 147 patients) at ECHO sites (P = 0.57). Serious adverse events occurred in 13.7% of the patients at the UNM HCV clinic and in 6.9% of the patients at ECHO sites. The results of this study show that the ECHO model is an effective way to treat HCV infection in underserved communities. Implementation of this model would allow other states and nations to treat a greater number of patients infected with HCV than they are currently able to treat.