tbuckley/cabot-search huggingface dataset:
Abstract A45: Inflammatory biomarker c-reactive protein in radiotherapy-induced skin toxicities of breast cancer patients.
Authors: Jorge L. Rodriguez-Gil, Anne Cooley, Venetta Thomas, Cristiane Takita, Jean Wright, Martine Poitevien, Glenn O. Allen, Isildinha M. Reis, Wei Zhao, Jennifer J. Hu
Journal: Cancer Research (2013)

Abstract Purpose: Post-surgery adjuvant radiotherapy (RT) significantly reduces recurrence and metastasis of breast cancer. However, many patients experience early adverse skin reactions (EASRs) that impact quality of life. This study evaluated an inflammatory biomarker C-reactive protein (CRP) in RT-induced EASRs in breast cancer patients undergoing RT. Methods: We recruited 159 breast cancer patients undergoing RT after breast conserving surgery. The pre- and post-RT plasma CRP levels were measured using a highly-sensitive ELISA CRP assay. RT-induced EASRs were assessed at weeks 3 and 6 using the National Cancer Institute Common Toxicity Criteria (v3.0). Results: RT-induced grade 2+ skin toxicities were observed in 8 (5%) and 79 (50%) patients at weeks 3 and 6, respectively. Significantly higher proportions of African Americans developed grade 3 skin toxicities (13.8% vs. 2.3% in Whites) at week 6. In multivariate analysis, there was a suggestive association between grade 2+ skin toxicities at week 3 and &amp;gt;2 mg/L pre-RT CRP (OR=4.68, 95%CI=0.49, 44.94). However, grade 2+ skin toxicities at week 6 were significantly associated with elevated: CRP &amp;gt; 1 mg/L (OR=3.26; 95%CI=1.35, 7.85, p=0.01), obesity (OR=2.39; 95%CI=1.19, 4.83, p=0.02), or combined both factors (OR=7.80; 95%CI=2.59, 23.49, p&amp;lt;0.001). Conclusion: This is the first study to suggest that CRP has value as an inflammatory biomarker in RT-induced EASRs, particularly combined with obesity. Future larger studies are warranted to validate our findings and facilitate the discovery and development of anti-inflammatory agents to protect normal tissue from RT-induced adverse effects and improve quality of life in breast cancer patients undergoing RT. Citation Format: Jorge L. Rodriguez-Gil, Anne Cooley, Venetta Thomas, Cristiane Takita, Jean Wright, Martine Poitevien, Glenn O. Allen, Isildinha M. Reis, Wei Zhao, Jennifer J. Hu. Inflammatory biomarker c-reactive protein in radiotherapy-induced skin toxicities of breast cancer patients. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Immunology: Multidisciplinary Science Driving Basic and Clinical Advances; Dec 2-5, 2012; Miami, FL. Philadelphia (PA): AACR; Cancer Res 2013;73(1 Suppl):Abstract nr A45.
Three out of 12 hospitals fail to meet essential standards of care of older people, finds watchdog
Authors: H. Mooney
Journal: BMJ (2011)

Older patients in some NHS hospitals are being left to go hungry and thirsty, and are not being shown the respect they deserve, according to a series of damning reports by the Care Quality Commission (CQC).

The first 12 reports into care of older people by the CQC examine whether older people receive essential standards of care in NHS hospitals throughout England. They found that three hospitals were failing to meet the essential legal standards. CQC inspectors also had less serious concerns about three other trusts, but found the other six were performing as they should.

At Worcestershire Acute Hospitals NHS Trust, the Ipswich Hospital NHS Trust, and Royal Free Hampstead NHS Trust the commission found “a bleak story of people not being helped to eat and drink, …
Overtube-assisted placement of a metal stent into the bile duct of a patient with surgically altered upper-gastrointestinal anatomy during double-balloon enteroscopy-assisted ERCP
Authors: Matthew Skinner, Juan Gutierrez, C. Wilcox, Klaus Mönkemüller
Journal: Endoscopy (2013)

We here report on a novel approach to deliver a fully covered self-expanding metal stent (SEMS) into the bile duct during double-balloon enteroscopy (DBE)-assisted endoscopic retrograde cholangiopancreatography (ERCP) using the overtube as an "accessory" or working channel.
Sodium channel states control binding and unbinding behaviour of antiarrhythmic drugs in cardiac myocytes from the guinea pig
Authors: S.-i. Koumi, R. Sato, R. Katori, I. Hisatome, K. Nagasawa, H. Hayakawa
Journal: Cardiovascular Research (1992)

Objective: The aim was to investigate whether cardiac sodium channel states (rested, activated, inactivated) regulate the binding and unbinding behaviour of antiarrhythmic drugs on the receptor sites. Methods: Single ventricular myocytes of adult guinea pig heart were obtained by an enzymatic dissociation method in the Langendorff manner. The channel state dependent blocking effects on cardiac sodium current (INa) of quinidine and disopyramide were studied under the whole cell variation of the patch clamp technique. Results: 10 μM quinidine and 20 μM disopyramide produced similar levels of tonic block and use dependent block. The steady state inactivation curve (h∞ curve) was shifted parallel in the negative potential direction by quinidine (10 μM) and disopyramide (20 μM) to the same extent (-10 mV). Removal of the fast inactivation process of INa by chloramine-T did not reduce tonic and use dependent block by these drugs. Onset block study using a double pulse protocol revealed that block developments by both drugs were fitted to the sum of double exponential functions. However, time constant of fast phase of block by disopyramide was faster than that by quinidine, while slow phase was not significantly different. Definition of time courses of unbinding (recovery) at -140 mV indicated that quinidine dissociated relatively slowly as compared to disopyramide. Conclusions: Quinidine produces more potent tonic and use dependent block of INa by binding to sodium channels at both rested and inactivated states, while disopyramide has a higher affinity for activated state. Therefore, sodium channel states regulate the binding and unbinding behaviour of antiarrhythmic drugs. Furthermore, the fast inactivation process is not essential in producing tonic and use dependent block by antiarrhythmic drugs. Cardiovascular Research 1992:26:1199-1205
Substance misuse in psychiatric inpatients: comparison of a screening questionnaire survey with case notes
Authors: B. Barnaby
Journal: BMJ (2003)

scale in 1976 was not accompanied by an explanation and did not result in a clarifying change of name.No evidence has been published that the continued use of the 14 point scale may have caused harm to any patient.The practice does, however, lead to difficulties.Staff from one hospital told us about their recurrent problems communicating with the local neurosurgical unit because the two were using different scales.In another trust, the neurological observation charts were changed after a recent coroner's inquest: relatives of a patient who had died of severe traumatic brain injury had raised questions about the logic of two different versions of the Glasgow coma scale being used within the same trust.Users of the Glasgow coma scale need training to ensure consistency and reliability of scoring. 5 The continued employment of two different scales can only add to the confusion.Although the 15 point Glasgow coma scale is not perfect, it should be used by everybody who manages patients with traumatic brain injuries until even better measures of consciousness are devised.I thank D Wallis for help with the study design and E Glucksman and P Leman for their comments on the drafts.
Medical Research Activities, Funding, and Creativity in Europe
Authors: Lennart Philipson
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Air embolism and intravenous catheters.
Authors: E Metcalfe, D Griffiths, J L Peters, N M Greenwood
Journal: BMJ (1979)

1979diagnosis, or both.The biochemist then decides what tests, if any, will help.Moreover, no report would leave the department without an expert interpretation of the result.To implement such a proposal would require a drastic change in the philosophy of both clinicians and biochemists; but it is, of course, the only logical solution.
PER2 Controls Lipid Metabolism by Direct Regulation of PPARγ
Authors: Benedetto Grimaldi, Marina Maria Bellet, Sayako Katada, Giuseppe Astarita, Jun Hirayama, Rajesh H. Amin, James G. Granneman, Daniele Piomelli, Todd Leff, Paolo Sassone-Corsi
Journal: Cell Metabolism (2010)
Cytomegalovirus as a possible cause of a disease resembling infectious mononucleosis.
Authors: E. Klemola, L. Kaariainen
Journal: BMJ (1965)

No simple correlation between bowel habit and age was observed.There was no correlation between bowel habit and nationality.Four per cent. of the industrial population and 16% of those seen in general practice regarded themselves as " constipated."The use of this term sometimes correlated with infrequent bowel actions, and sometimes with hardness of the stool, but often it bore no relation to bowel frequency or stool consistency.A correlation was observed between increasing bowel frequency and the subjects' opinion of the stool as " loose."Of the total population 19.7% (16% in the industrial com- munity, 29 % in general practice) took laxatives.The difference between the two series with regard to laxative-taking can be ascribed to different age distributions within the samples.The proportion of subjects who took laxatives increased with age in both series.No subject under 20 took laxatives more than once weekly, and only three of the 266 subjects in this age group took any laxatives.Only 20 % of those who took laxatives in the combined series considered themselves " constipated."We thank Lord Trenchard, chairman of T. Wall and Sons (Meat and Handy Foods) Ltd., for agreeing to the undertaking of this survey in the three factories, and the staff of the Company Medical Service who made it possible.We thank Dr. H. N.
Response to Comment on: Hegde et al. Effect of 3-Month Yoga on Oxidative Stress in Type 2 Diabetes With or Without Complications: A Controlled Clinical Trial. Diabetes Care 2011;34: 2208–2210
Authors: Shreelaxmi V. Hegde, Prabha Adhikari, Shashidhar Kotian, Veena J. Pinto, Sydney D’Souza, Vivian D’Souza
Journal: Diabetes Care (2012)

We appreciate the thoughtful comments by Sperandei (1) on our article (2).Following are the requested clarifications.Sperandei's first question was on how we could use paired t test and the Wilcoxon signed rank test for analyzing unpaired variables between two groups even though these tests are designed for paired variables.We would like to respond that we had used paired t test to see the changes from before and after within a group, which is mentioned in the article.We apologize because Mann-Whitney U test was adopted to compare the variables between the groups, but this was wrongly stated as Wilcoxon signed rank test in the article.This error does not have any impact on the results stated.Sperandei's concern is that ANOVA with repeated measures was the right analysis for the current study.We could have used ANOVA as well, but because followup was not repeated several times we preferred to use the Student paired t test.Sperandei's next question was on how there was a significant decrease of health status only in the control group under standard care.We would like to state that standard care does not worsen the status of diabetes.Diabetes is a progressive disease with gradual b-cell failure and increasing oxidative stress.This progresses despite standard care.Diabetes needs intensification of treatment once a month or once in 3 months.In our study, standard care was kept a constant, and hence we saw deterioration with regard to HbA 1c levels only in the control group.Because the yoga group performed additional yoga, HbA 1c levels were reduced, which reflects an improvement in health status of the diabetic patients.
Role of the liver in splanchnic extraction of atrial natriuretic factor in the rat
Authors: Alexander L. Gerbes, Rochus Witthaut, Veit Gülberg, Gaétan Thibault, Manfred Bilzer, Dieter Jüngst
Journal: Hepatology (1992)

Mesenteric, hepatic and splanchnic extraction of C–terminal and N–terminal atrial natriuretic factor was investigated in male Sprague–Dawley rats. Plasma concentrations (mean ± S.E.M.) of C–terminal atrial natriuretic factor were 55.0 ± 6.1 fmol/ml, 31.2 ± 4.0 fmol/ml and 23.5 ± 3.3 fmol/ml (n = 12) in the abdominal aorta, the portal vein and the hepatic vein, respectively. N–terminal atrial natriuretic factor plasma levels in these vessels were 3031 ± 756 fmol/ml, 2264 ± 661 fmol/ml and 1618 ± 496 fmol/ml (n = 6), respectively. Although the mesenteric extraction ratio was higher (p &lt; 0.05) for C–terminal atrial natriuretic factor (42% ± 6%) than for N–terminal atrial natriuretic factor (28% ± 4%), there were no significant differences in the hepatic extraction ratio (41% ± 5% vs. 39% ± 6%) and the splanchnic extraction ratio (56% ± 5% vs. 50% ± 7%). These data suggest a major role of the liver in the splanchnic extraction of C–terminal and of N–terminal atrial natriuretic factor in the rat. (Hepatology 1992;16:790-793.)
Lineage-Specific Dependency of Lung Adenocarcinomas on the Lung Development Regulator TTF-1
Authors: Hisaaki Tanaka, Kiyoshi Yanagisawa, Keiko Shinjo, Ayumu Taguchi, Ken Maeno, Shuta Tomida, Yukako Shimada, Hirotaka Osada, Takayuki Kosaka, Hideo Matsubara, Tetsuya Mitsudomi, Yoshitaka Sekido, Mitsune Tanimoto, Yasushi Yatabe, Takashi Takahashi
Journal: Cancer Research (2007)

Abstract Emerging evidence, although currently very sparse, suggests the presence of “lineage-specific dependency” in the survival mechanisms of certain cancers. TTF-1 has a decisive role as a master regulatory transcription factor in lung development and in the maintenance of the functions of terminal respiratory unit (TRU) cells. We show that a subset of lung adenocarcinoma cell lines expressing TTF-1, which presumably represent those derived from the TRU lineage, exhibit marked dependence on the persistent expression of TTF-1. The inhibition of TTF-1 by RNA interference (RNAi) significantly and specifically induced growth inhibition and apoptosis in these adenocarcinoma cell lines. Furthermore, a fraction of TTF-1–expressing tumors and cell lines displayed an increase in the gene dosage of TTF-1 in the analysis of 214 patients with non–small-cell lung cancer, including 174 adenocarcinomas, showing a tendency of higher frequency of increased gene copies at metastatic sites than at primary sites (P = 0.07, by two-sided Fisher's exact test). These findings strongly suggest that in addition to the development and maintenance of TRU lineages in normal lung, sustained TTF-1 expression may be crucial for the survival of a subset of adenocarcinomas that express TTF-1, providing credence for the lineage-specific dependency model. [Cancer Res 2007;67(13):6007–11]
Complication of tuberculous meningitis.
Authors: M. I. Drury, S. O'Lochlainn, E. Sweeney
Journal: BMJ (1968)

detected material with similar chromato- graphic solubility characteristics in the faeces of normal subjects and patients with a variety of porphyric syndromes.The authors seem to us unjustifiably reluctant to accept alternative diagnoses or explanations for the many clinical syndromes described.Cerebral symptoms of confusion, stupor, con- vulsions, and coma in many of the subjects could easily have been due to uraemia, dehydration, alkalosis after prolonged vomiting, or many other toxic or infective states.The ileus and generalized weakness described in some of the patients may well have been the result of hypokalaemia-a well-known complication of protracted vomiting, Jiarrhoea, or violent purgation.Repeated bloodietting may also have contributed to the profound >weakness experienced by many of the subjects.Drs.Macalpine and Hunter discard the diagnosis of gout made by the physicians of the time in several of the descendants of James VI, pre- ferring to regard acute porphyria as the explana- don of a limb pain that the patients experienced.Surely Sydenham's masterly 17th-century account of the clinical features of this disorder indicates that gout as a diagnostic entity was well known to physicians of the era and was diag- nosed by them on reasonably sound clinical grounds.There is certainly nothing in the
In irradiation chimeras, K or D regions of the chimeric host, not of the donor lymphocytes, determine immune responsiveness of antiviral cytotoxic T cells
Authors: RM Zinkernagel, A Althage, S Cooper, G Callahan, J Klein
Journal: The Journal of Experimental Medicine (1978)

The H-2 haplotype of the chimeric host determines the responder phenotype of maturing T cells. Spleen cells of chimeric mice formed when (K(k) nonresponder to D(b) × K(b) responder to D(b) plus vaccinia)F(1) bone marrow cells were used to reconstitute K(b)D(b) (C57BL/6 D(b) responder) irradiated recipients generated high levels of D(b) plus vaccinia virus-specific cytotoxic T cells. The same stem cells used to reconstitute K(k)D(b) (B10.A (2R) D(b) nonresponder) irradiated recipients resulted in spleen cells that responded well to K plus vaccinia, but responsiveness to D(b) was low. A generally low response to D(k) plus vaccinia, which seems to be regulated by D(k), was confirmed in chimeras. Thus, K(d)D(d) (D(d) plus vaccinia responder) stem cells differentiating in a K(d)D(k) chimeric host failed to generate a measurable response to D(k) plus vaccinia. In contrast, stem cells from K(d)D(k) (D(k) plus vaccinia low responders) differentiating in a K(d)D(d) (K(d) and D(d) high responders to vaccinia) host do generate responsiveness to D(d) plus vaccinia. These results indicate that in chimeras, the Ir phenotype is independent of the donor T cell's Ir genotype, and that thymic selection of a T cell's restriction specificity for a particular H-2 allele of the chimeric host also defines that T cell's Ir phenotype.
Prolactin and Contact Sensitivity
Authors: E. Nagy, I. Berczi
Journal: Allergy (1981)

Hypophysectomized (Hypo‐X) rats did not develop contact dermatitis in response to dinitrochlorobenzene (DNCB). Syngeneic pituitary grafts placed under the kidney capsule or daily treatment with prolactin restored the DNCB‐reactivity of Hypo‐X animals. Combined treatment with other pituitary hormones was ineffective. Treatment of normal rats with a potent prolactin antagonist drug, bromocriptine, was as effective in inhibiting contact sensitivity as was hypophysectomy. These results indicate that contact sensitivity is a prolactin dependent reaction.
EFFECTS OF EVOLOCUMAB ON LIPOPROTEIN PARTICLES AND SUBCLASSES IN HYPERCHOLESTEROLEMIC AND HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA SUBJECTS ON STATIN THERAPY
Authors: Ren Xu, Clapton Dias, Matt Peach, Bing Gao, Lisa Hamilton, Brian Smith, Blaire Cooke, Simon Jackson, Adam Shaywitz, Dan Fitzpatrick, Rob Scott, Scott Wasserman
Journal: Journal of the American College of Cardiology (2014)
Effect of a perfluorocarbon emulsion (Fluosol‐DA) on reticuloendothelial system clearance function
Authors: Oswaldo Castro, Aleta E. Nesbitt, Denise Lyles
Journal: American Journal of Hematology (1984)

Abstract To study the effect of a perfluorocarbon oxygen transport emulsion (Fluosol‐DA) on reticuloendothelial system (RES) function, we measured the blood clearance of human erythrocytes transfused to rats. Compared with saline treatment, Fluosol‐DA at 30 ml/kg doses significantly increased both the percent 20‐hour blood recovery (mean 8.9% ± 2.7 SEM vs 1.3% ± 0.25 SEM) and 51 Cr t1/2 survival (mean 14.0 hours ± 2.7 SEM vs 3.5 hours ± 0.33 SEM) of the human red cells. This suppression of RES clearance function was transient and no longer detectable seven days after single Fluosol‐DA doses. The Fluosol‐DA‐induced RES block was about three times greater than that obtainable with 4 g/kg of a soybean oil emulsion used for clinical hyperalimentation. On the other hand, the effect of ethyl palmitate (0.5 g/kg), a potent but toxic RES blocker, was 3.5 times greater than that of Fluosol‐DA in this test system. If Fluosol‐DA also induces RES block in humans, this emulsion could be explored as a therapeutic RES blocker in certain immune cytopenias.
Sustained pulmonary hypertension and right ventricular hypertrophy after chronic hypoxia in mice with congenital deficiency of nitric oxide synthase 3.
Authors: W Steudel, M Scherrer-Crosbie, K D Bloch, J Weimann, P L Huang, R C Jones, M H Picard, W M Zapol
Journal: Journal of Clinical Investigation (1998)

Chronic hypoxia induces pulmonary hypertension and right ventricular (RV) hypertrophy. Nitric oxide (NO) has been proposed to modulate the pulmonary vascular response to hypoxia. We investigated the effects of congenital deficiency of endothelial NO synthase (NOS3) on the pulmonary vascular responses to breathing 11% oxygen for 3-6 wk. After 3 wk of hypoxia, RV systolic pressure was greater in NOS3-deficient than in wild-type mice (35+/-2 vs 28+/-1 mmHg, x+/-SE, P < 0.001). Pulmonary artery pressure (PPA) and incremental total pulmonary vascular resistance (RPI) were greater in NOS3-deficient than in wild-type mice (PPA 22+/-1 vs 19+/-1 mmHg, P < 0.05 and RPI 92+/-11 vs 55+/-5 mmHg.min.gram.ml-1, P < 0.05). Morphometry revealed that the proportion of muscularized small pulmonary vessels was almost fourfold greater in NOS3-deficient mice than in wild-type mice. After 6 wk of hypoxia, the increase of RV free wall thickness, measured by transesophageal echocardiography, and of RV weight/body weight ratio were more marked in NOS3-deficient mice than in wild-type mice (RV wall thickness 0.67+/-0.05 vs 0.48+/-0.02 mm, P < 0.01 and RV weight/body weight ratio 2.1+/-0.2 vs 1.6+/-0.1 mg. gram-1, P < 0.05). RV hypertrophy produced by chronic hypoxia was prevented by breathing 20 parts per million NO in both genotypes of mice. These results suggest that congenital NOS3 deficiency enhances hypoxic pulmonary vascular remodeling and hypertension, and RV hypertrophy, and that NO production by NOS3 is vital to counterbalance pulmonary vasoconstriction caused by chronic hypoxic stress.
Low influenza-vaccination rate among adults receiving immunosuppressive therapy for systemic inflammatory disease
Authors: F Lanternier, C Henegar, L Mouthon, P Blanche, L Guillevin, O Launay
Journal: Annals of the Rheumatic Diseases (2008)

Although annual influenza vaccination is recommended for adults taking immunosuppressant drugs,1–3 the vaccination rate is suboptimal in these patients.4–6 We undertook a study to assess the flu-vaccination uptake of patients treated for systemic inflammatory diseases and to explore the factors that influence it. The study was approved by the Paris Ile de France III Ethics Committee (“Comite de Protection des Personnes Ile de France III”) Paris, France.

We collected information about flu shots with a standardised form completed by the doctors of patients with systemic inflammatory diseases taking corticosteroids and/or immunosuppressant drugs, followed up in our internal medicine department during January 2006.

One hundred and thirty-seven consecutive …