tbuckley/cabot-search huggingface dataset:
The fine art of patient-doctor relationships
Authors: M P Park, R H R Park
Journal: BMJ (2004)

Paintings depicting patient-doctor relationships have been created for different reasons-among them gestures of gratitude and as a form of therapy At Christmas many doctors experience brief but well intentioned and tangible gestures of successful patientdoctor relationships.Various patients' gifts, such as boxes of chocolates or bottles of wine, are always appreciated by the recipient.Although doctors may receive more permanent gifts, very few will have had the delight of having their portrait painted by their patient.Artists from different ages and cultures-Goya, Kahlo, Bellany, Van Gogh, Munch, and Dadd-have all had the desire to record their special relationship with their doctors.
Abstract 2493: Inhibition of phosphoinositide 3-kinase suppressed growth of cancer cells with PIK3CA mutations or loss of PTEN expression via G0/G1 arrest of cell cycle but not apoptosis
Authors: Shingo Dan, Mutsumi Okamura, Hisashi Yoshimi, Yumiko Mukai, Kanami Yamazaki, Yasumichi Inoue, Aki Hanyu, Takeshi Imamura, Asako Sakaue-Sawano, Atsushi Miyawaki, Takao Yamori
Journal: Cancer Research (2010)

Abstract Background: The phosphoinositide 3-kinase (PI3K) pathway is frequently activated in cancer by gain-of-function mutation of PIK3CA and loss of PTEN expression, and mediates growth- and anti-apoptotic signals. Therefore, PI3K is considered as a promising therapeutic target to inhibit growth and to induce apoptosis in such cancers. We previously developed a novel PI3K-specific inhibitor ZSTK474 with antitumor efficacy (Yaguchi et al, J. Natl. Cancer Inst. 98: 545-56, 2006; Kong and Yamori, Curr. Med. Chem. 16: 2839-54, 2009). In this study, we have examined the cellular mechanism by which ZSTK474 exerts its antitumor efficacy in human cancer cells with or without PIK3CA/PTEN aberrations. Methods: We examined the antitumor effect of ZSTK474 on various human cancer cell lines with or without PIK3CA/PTEN aberration in vitro and in vivo. Protein expression and apoptosis in ZSTK474-treated and untreated tumor sections were analyzed by immunohistochemistry and TUNEL assay, respectively. Analysis of cell cycle in vitro was determined by flow cytometry and by Fucci (Fluorescent Ubiquitination-based Cell Cycle Indicator) system introduced to cancer cells. Induction of apoptosis in vitro was estimated by caspase activation using a substrate cleavage assay and by detection of subdiploid cells using flow cytometry. Results: In vivo, ZSTK474 effectively inhibited the growth of human tumor xenograft derived from a PTEN-null prostate cancer cell line PC3. In parallel, ZSTK474 treatment suppressed the expression of phospho-Akt, suggesting effective PI3K inhibition, and also suppressed the expression of nuclear cyclin D1 and Ki67, both of which are hallmarks of proliferation. However, ZSTK474 treatment did not increase TUNEL-positive apoptotic cells. Similar result was obtained in another PTEN-negative cell line KM-12 and three PIK3CA-mutated cell lines HCT-15 (E545K), MKN1 (E545K) and SK-OV3 (H1047R). In vitro, ZSTK474 induced marked G0/G1 arrest accompanied by a decrease of nuclear cyclin D1, induction of p27kip1 and p15ink4b, and hypophosphorylation of pRB in PC-3 cells. However, ZSTK474 did not increase the subdiploid cells or activate caspase, both of which are hallmarks of apoptosis. Similar result was obtained other cell lines with or without PIK3CA /PTEN aberrations. Conclusion: These results clearly indicated that ZSTK474 did not induce apoptosis but rather induced strong G0/G1 arrest in cancer cells with or without PIK3CA/PTEN aberrations, which might cause its therapeutic efficacy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2493.
Interleukin-2 and Regulatory T Cells in Graft-versus-Host Disease
Authors: John Koreth, Ken Ichi Matsuoka, Haesook T. Kim, Sean M. McDonough, Bhavjot Bindra, Edwin P. Alyea, Philippe Armand, Corey Cutler, Vincent T. Ho, Nathaniel S. Treister, Don C. Bienfang, Sashank Prasad, Dmitrios Tzachanis, Robin M. Joyce, David E. Avigan, Joseph H. Antin, Jerome Ritz, Robert J. Soiffer
Journal: New England Journal of Medicine (2011)

Dysfunction of regulatory T (Treg) cells has been detected in diverse inflammatory disorders, including chronic graft-versus-host disease (GVHD). Interleukin-2 is critical for Treg cell growth, survival, and activity. We hypothesized that low-dose interleukin-2 could preferentially enhance Treg cells in vivo and suppress clinical manifestations of chronic GVHD.
Parents' vigil ends in tragedy after mix-up in identities
Authors: Bojan Pancevski
Journal: BMJ (2006)

An Austrian couple who kept a five month vigil beside the bed of a teenager in a coma who they thought was their son discovered he was a different person when he woke up and started speaking in a foreign language.

In a bizarre mix-up, the couple's real son had actually been killed in a car crash and buried in the place of his Bosnian best friend, who had been travelling in the car with him. Each set of parents had apparently wrongly identified their sons, both of whom had severe injuries.

The incident is similar to a case in the US state of Michigan last month, when the family of the victim of a car crash, Laura Van Ryn, 22, waited five weeks at the bedside of their comatose daughter only to realise when she awoke that she was their daughter's friend Whitney Cerak, 19. In the meantime their daughter had been buried …
Comparison of histopathologic–clinical characteristics of Jessner's lymphocytic infiltration of the skin and lupus erythematosus tumidus: Multicenter study of 46 cases
Authors: Valérie Rémy-Leroux, Fabienne Léonard, Daniel Lambert, Janine Wechsler, Bernard Cribier, Pierre Thomas, Henri Adamski, Marie-Claude Marguery, François Aubin, Dominique Leroy, Philippe Bernard
Journal: Journal of the American Academy of Dermatology (2007)
New AMA Alliance Leader Turns Education Into Action
Authors: Anne Stein
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Incidental Detection of Carcinoid With Tc-99m–Labeled Carcinoembryonic Antigen Monoclonal Antibody Scintigraphy During Evaluation of Metastatic Colon Cancer
Authors: INKU HWANG, PATRICIA M. KULAS, BENJAMIN W. STARNES, ANTONIO G. BALINGIT, CRAIG D. SHRIVER
Journal: Clinical Nuclear Medicine (1999)

A 63-year-old man was referred for increasing carcinoembryonic antigen (CEA) levels 2 years after sigmoid resection for colon cancer. He reported fatigue, diarrhea, and tenesmus. A physical examination and laboratory evaluations were notable only for the abnormal CEA level of 24 pg/ml (normal, 0–5 pg/ml). Colonoscopy, chest radiograph, bone scan, and CT with contrast were unremarkable. Tc-99m CEA scintigraphy revealed an abnormality near the right kidney, which was later localized with a gamma probe and found to be carcinoid. Although both colorectal carcinoma and carcinoid may have a histogenetic relation to typically mucinous adenocarcinomas, produce CEA, and can occur concurrently (called “collision tumors”), this is not well described with CEA scintigraphy. This is the first report of such a case found with a CEA scan.
CUTANEOUS ANGIITIS.
Authors: P. W. M. COPEMAN, T. J. RYAN
Journal: British Journal of Dermatology (1971)

SUMMARY.— In health the skin blood vessels, being very close to the body surface, are exposed to the influence of cold. Cooling slows blood flow, and a slower flow, in itself, increases the viscosity of whole blood. This alteration in the flow properties of blood encourages the development of patterns of pinkness and blueness that are determined by the anatomical arrangement of the blood vessels in the skin. In angiitic processes, because of these natural properties of blood, the clinical signs are displayed as a rash made up either of small punctate capillary‐venular lesions (toxic erythema), or a large reticulate pattern. The pathological processes in livedo reticularis are found at the periphery of the pink zones on the bluish network. Both of these components of the rash may be seen in the same eruption. In patients, these signs can be regarded in some respects not so much as a skin disease but as a cutaneous manifestation of a blood disorder (as, say, after the development of a cold‐precipitable protein‐aemia), the pattern of which will have been determined by the distribution of the blood vessels.
Contemporary Management of Male Infertility
Authors: Peter J. Stahl, Doron S. Stember, Marc Goldstein
Journal: Annual Review of Medicine (2011)

Knowledge of normal male reproductive function and familiarity with the diagnostic evaluation and treatment of male subfertility is beneficial for most physicians. Male subfertility is often correctable, may be genetically transmissible, and may be associated with occult health-threatening conditions. Herein we present an overview of male reproductive medicine, which has been revolutionized in the past two decades by dramatic scientific and therapeutic advances. The development of intracytoplasmic sperm injection and its successful application to sperm retrieved from the epididymis or testis have made biological paternity possible in men previously considered sterile. Microsurgical techniques for vasal-epididymal reconstruction and sperm retrieval have been refined. Novel tests of semen quality have been developed. Medical therapies to improve sperm production, such as estrogen receptor modulation and aromatase inhibition, have been used increasingly in clinical practice. Finally, associations between male subfertility and a spectrum of health-threatening conditions have been recognized.
Quarantine! East European Jewish Immigrants and the New York City Epidemics of 1892
Authors: David R. Hinthorn
Journal: Annals of Internal Medicine (1997)

Medical Writings15 November 1997Quarantine! East European Jewish Immigrants and the New York City Epidemics of 1892David R. Hinthorn, MDDavid R. Hinthorn, MDUniversity of Kansas School of Medicine, Kansas City, KansasAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-10-199711150-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Markel H. 262 pages. Baltimore: Johns Hopkins Univ Pr; 1997. $29.95. ISBN 0801855128. Order phone 800-537-5487.Field of medicine: History of medicine, microbiology, infectious diseases, public health, and legal medicine.Audience: Students of the history of medicine and the development of ethics and persons who work in public health, legal medicine, microbiology, or infectious diseases.Purpose: To show alternative views of the handling of the 1892-1893 epidemics of typhus and cholera in New York City and the impact of quarantine on the lives of Eastern European Jewish immigrants.Content: Quarantine (physical, social, or mental isolation) is the book's focus. The ... Author, Article, and Disclosure InformationAffiliations: University of Kansas School of Medicine, Kansas City, Kansas PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byKnowledge, Attitude, Practice, and Fear of COVID-19: an Online-Based Cross-cultural StudyThe History of Malaria in the United States: How it Spread, How it was Treated, and Public Responses 15 November 1997Volume 127, Issue 10Page: 950KeywordsCholeraHistory of medicineInfectious diseasesJewish peopleLegislationMicrobiologyPrevention, policy, and public healthPublic policyQuarantinesTyphus ePublished: 15 August 2000 Issue Published: 15 November 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Acute profound thrombocytopenia following C7E3 Fab (abciximab) therapy: Case reports, review of the literature and implications for therapy
Authors: Steven J. Jubelirer, Beth A. Koenig, Mark C. Bates
Journal: American Journal of Hematology (1999)

Platelets play a crucial role in the ischemic complications of percutaneous coronary procedures. The recent availability of C7E3 Fab (Abxiximab or ReoPro™), a chimeric monoclonal antibody Fab fragment directed against the platelet glycoprotein IIb/IIIa receptor, has reduced abrupt closure and other adverse events and lessened the need for revascularization procedures. As the use for this drug has increased, rare cases of severe thrombocytopenia have been revealed. From August 1995 to June 1997, 452 patients at Charleston Area Medical Center who underwent percutaneous coronary revascularization procedures and were treated with abciximab were evaluated for the development of severe thrombocytopenia (i.e., platelet count less than 20,000 within 48 hr of treatment). A review of published reports of severe thrombocytopenia was also reviewed. A review of published reports of abciximab-induced severe thrombocytopenia, as well as our three cases, reveals that: 1) the incidence is less than 0.7%; 2) the nadir platelet count (range 1,000–16,000) was noted within 2–31 hr after abciximab infusion; 3) the platelet count increases to greater than 100,000 within 12 days in all patients; 4) bleeding episodes were treated with platelet transfusion with an improvement in platelet count within 24 hr in all patients in whom they were given; and 5) in the one patient treated with γ globulin alone, no significant rise in platelet count was noted. Acute severe thrombocytopenia can occur after ReoPro™ administration. Its development is not predictable and may occur within 2 hr of administration. Thrombocytopenia, therefore, requires consideration in every patient treated with this drug. It appears prudent to obtain a platelet count 2 hr after initiating ReoPro™. If thrombocytopenia develops, then the drug can be stopped in a timely manner and platelet transfusion can be given. Am. J. Hematol. 61:205–208, 1999. © 1999 Wiley-Liss, Inc.
Life Events and Social Support in Prediction of Stroke Outcome
Authors: Morten Birket-Smith, Helle Charlotte Knudsen, Jørn Nissen, Niels Blegvad, Ole Køhler, Dorte Rasmussen, Søren Worm-Petersen
Journal: Psychotherapy and Psychosomatics (1989)

A prospective study of 252 patients (average age 73, range 26-95) admitted to a regional general hospital over a 12-month period was carried out. 241 patients had stroke verified by the initial neurological examination and CT scan, and of these baseline data were not available on 27%. 34% died before or were not willing or able to provide data at follow-up. 39% survived and completed the study. Prestroke life events and social support could not predict the outcome of stroke rehabilitation measured as survival, length of stay, functional recovery (Barthel's Index) or placement at the follow-up 12 months after the onset of stroke. Age and arteriosclerotic heart disease predicted poor survival at follow-up. Premorbid hypertension, stroke, diabetes, obesity, tobacco smoking, and alcohol consumption did not significantly influence the outcome. Problems in stroke rehabilitation research are discussed.
Increased neutrophilia in nasal polyps reduces the response to oral corticosteroid therapy
Authors: Weiping Wen, Wenlong Liu, Luo Zhang, Jing Bai, Yunping Fan, Wentong Xia, Qing Luo, Jing Zheng, Hongtian Wang, Zuwang Li, Jiahong Xia, Hongyan Jiang, Zheng Liu, Jianbo Shi, Huabin Li, Geng Xu
Journal: Journal of Allergy and Clinical Immunology (2012)
Polycyclic aromatic hydrocarbon metabolites in urine as biomarkers of exposure and effect.
Authors: P Strickland, D Kang, P Sithisarankul
Journal: Environmental Health Perspectives (1996)

Humans are exposed to polycyclic aromatic hydrocarbons (PAHs) from various occupational, environmental, medicinal, and dietary sources. PAH metabolites in human urine can be used as biomarkers of internal dose to assess recent exposure to PAHs. PAH metabolites that have been detected in human urine include 1-hydroxypyrene (1-OHP), 1-hydroxypyrene-O-glucuronide (1-OHP-gluc), 3-hydroxybenzo[a]pyrene, 7,8,9,10-tetrahydroxy-7,8,9, 10-tetrahydrobenzo[a]pyrene, and a number of other hydroxylated PAHs. The most widely used of these is 1-OHP-gluc, the major form of 1-OHP in human urine, by virtue of its relatively high concentration and prevalence in urine and its ease of measurement. This metabolite of pyrene can be measured as 1-OHP after deconjugation of the glucuronide with beta-glucuronidase or directly as 1-OHP-gluc without deconjugation. Elevated levels of 1-OHP or 1-OHP-gluc have been demonstrated in smokers (versus nonsmokers), in patients receiving coal tar treatment (versus pretreatment), after workshifts in road pavers (versus before shifts or versus controls), after shifts in coke oven workers (versus before shift), and in subjects ingesting charbroiled meat (versus preingestion). More importantly, this metabolite is found (at low levels) in most human urine, even in persons without apparent occupational or smoking exposure. Although measurement of these metabolites is useful in assessing recent exposure to PAHs, their value as predictive markers of biological effect or health outcomes has not been rigorously tested and at present can only be inferred by association.
Ultrasound Strain Imaging of Altered Myocardial Stiffness
Authors: Cristina Pislaru, Charles J. Bruce, Peter C. Anagnostopoulos, Jill L. Allen, James B. Seward, Patricia A. Pellikka, Erik L. Ritman, James F. Greenleaf
Journal: Circulation (2004)

In this study we evaluate the diastolic deformation of ischemic/reperfused myocardium and relate this deformation to tissue elastic properties.Farm pigs were subjected to left anterior descending coronary artery occlusion followed by reperfusion to create either stunning (n=12) or transmural myocardial infarction (n=12). Ultrasound-derived radial strain rates (SR) and strain were measured in the ischemic and remote walls. Myocardial stiffness was estimated from diastolic pressure-wall thickness relationship obtained from preload alterations. At reperfusion, end-systolic strain (epsilon(sys)) was significantly reduced in both stunned and infarcted walls compared with their remote walls (3+/-3% versus 26+/-2% and 1+/-0% versus 33+/-5%, respectively; P<0.0001) or baseline values. Diastolic passive deformation (epsilon(A)) and rates of deformation during early (E(SR)) and late (A(SR)) diastole were comparable between stunned and remote walls (epsilon(A): 7.3+/-1.6% versus 7.9+/-1.9%; E(SR): -2.7+/-0.4 s(-1) versus -2.6+/-0.5 s(-1); A(SR): -1.8+/-0.2 s(-1) versus -1.9+/-0.3 s(-1); P=NS for all) but were of significantly lower magnitude in infarcted walls versus remote walls (epsilon(A): 1.1+/-0.2% versus 11.4+/-1.9%; E(SR): -0.3+/-0.1 s(-1) versus -2.4+/-0.4 s(-1); A(SR): -0.3+/-0.1 s(-1) versus -2.5+/-0.4 s(-1); P<0.0001 for all). Stiffness coefficient of exponential diastolic pressure-wall thickness relation was higher for infarcted (P<0.05) but not for stunned walls (P=NS) compared with their remote walls.Early after postischemic reperfusion and in the presence of severely reduced systolic deformation, diastolic passive deformation (and rates of deformation) can distinguish stiff, noncompliant, transmurally infarcted myocardial walls from those more compliant walls containing viable but stunned myocardium.
<i>CCR</i> 20th Anniversary Commentary: A Chimeric Antibody, C225, Inhibits EGFR Activation and Tumor Growth
Authors: John Mendelsohn, Marie Prewett, Patricia Rockwell, Neil I. Goldstein
Journal: Clinical Cancer Research (2015)

Murine mAb 225 was effective against the EGFR tyrosine kinase and inhibited tumor growth in preclinical studies. A phase I trial showed safety, tumor localization, and satisfactory pharmacokinetics. Human:murine chimeric C225 retained biologic activity, which was essential for the conduct of subsequent combination therapy trials and eventual regulatory approval.
Preventive surgery can cut risk of breast cancer by 90%
Authors: Zosia Kmietowicz
Journal: BMJ (2002)

Radical surgery to remove all breast tissue and ovaries may be the best treatment option for women with a high risk of getting breast or ovarian cancer, say researchers. Although drastic, the procedure is far more effective than the two other treatment options open to this group of women: yearly mammography and ultrasound scans or treatment with drugs such as tamoxifen.

About one in 800 women carry a mutated version of the BRCA 1 gene and have a 50-85% chance of getting breast cancer and a 15-60% chance of getting ovarian cancer, say researchers from the Cancer Research Centre at …
Enhanced anti-tumor activity and safety profile of targeted nano-scaled HPMA copolymer-alendronate-TNP-470 conjugate in the treatment of bone malignances
Authors: Ehud Segal, Huaizhong Pan, Liat Benayoun, Pavla Kopečková, Yuval Shaked, Jindřich Kopeček, Ronit Satchi-Fainaro
Journal: Biomaterials (2011)
Hepatosplenic γδ T‐cell lymphoma in a 10‐year‐old boy successfully treated with hematopoietic stem cell transplantation
Authors: Adam Gassas, Melanie Kirby, Sheila Weitzman, Bo Ngan, Oussama Abla, John J. Doyle
Journal: American Journal of Hematology (2004)

Abstract The authors report a 10‐year‐old boy with hepatosplenic γδ T‐cell lymphoma, a rare form of lymphoma that is highly aggressive, exceedingly rare in children, and primarily seen in young men. Conventional multi‐agent chemotherapy appears to be inadequate for cure. This is the first report with this type of lymphoma in a boy less than 15 years old treated with hematopoietic stem cell transplantation (HSCT). Am. J. Hematol. 75:113–114, 2004. © 2004 Wiley‐Liss, Inc.