tbuckley/cabot-search huggingface dataset:
Severe von Willebrand's Disease: Incidence and Prevalence
Authors: Ramon Velez, Kathryn Magruder-Habib
Journal: Annals of Internal Medicine (1984)

Letters and Corrections1 March 1984Severe von Willebrand's Disease: Incidence and PrevalenceRAMON VELEZ, M.D., M.SC., KATHRYN MAGRUDER-HABIB, PH.D.RAMON VELEZ, M.D., M.SC.Search for more papers by this author, KATHRYN MAGRUDER-HABIB, PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-100-3-465_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Little is known about the incidence and prevalence of severe von Willebrand's disease. A recent publication, however, has provided some of the first population-based data on the disease for the United States, Canada, and Europe (as well as Israel and Iran) (1). Although the report mislabeled the data as incidence, what is actually calculated is prevalance, that is, the number of existing cases of disease divided by the total population at a designated point in time (2).Capitalizing on the relation between incidence and prevalence (3), where the incidence rate = prevalence ratio/(average duration of disease [1...References1. WEISS H, BALL A, and MANNUCCI P. Incidence of severe von Willebrand's disease. N Engl J Med. 1982;307:127. CrossrefMedlineGoogle Scholar2. FRIEDMAN G. Medical usage and abusage: "prevalence and incidence." Ann Intern Med. 1976;84:502. LinkGoogle Scholar3. KLEINBAUM D, KUPPER L, and MORGENSTERN H. Epidemiologic Research. Belmont: Lifetime Learning Publications; 1982. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: RAMON VELEZ, M.D., M.SC.; KATHRYN MAGRUDER-HABIB, PH.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1984Volume 100, Issue 3Page: 465-465KeywordsResearch designvon Willebrand disease ePublished: 1 December 2008 Issue Published: 1 March 1984 PDF downloadLoading ...
A Three-Year Study of Myocardial Infarction in a Large Employed Population
Authors: Sidney Pell
Journal: JAMA (1961)

During a three-year period, 653 employees had an initial acute myocardial infarction. The incidence rate was much greater in men than in women, but the difference between the sexes decreased with increasing age. Executive personnel had the lowest incidence rate, while the highest rate was found in lower level salaried employees. The chances of developing an attack were about the same at work, at home, away on vacation, or at other places. Only 5.4 per cent of the patients were indulging in unusual physical exertion at the time of the attack. The case fatality rate was 31.4 per cent. The probability of survival was adversely affected by increasing age and, among older persons, by hypertension. The electrocardiograms of about 77 per cent of the patients were normal prior to the attack, but several kinds of abnormalities that were present were more common in the patients than in matched controls.
Glucose-induced alterations of cytosolic free calcium in cultured rat tail artery vascular smooth muscle cells.
Authors: M Barbagallo, J Shan, P K Pang, L M Resnick
Journal: Journal of Clinical Investigation (1995)

We have previously suggested that hyperglycemia per se may contribute to diabetic hypertensive and vascular disease by altering cellular ion content. To more directly investigate the potential role of glucose in this process, we measured cytosolic free calcium in primary cultures of vascular smooth muscle cells isolated from Sprague-Dawley rat tail artery before and after incubation with 5 (basal), 10, 15, and 20 mM glucose. Glucose significantly elevated cytosolic free calcium in a dose- and time-dependent manner, from 110.0 +/- 5.4 to 124.5 +/- 9.0, 192.7 +/- 20.4, and 228.4 +/- 21.9 nM at 5, 10, 15, and 20 mM glucose concentrations, respectively. This glucose-induced cytosolic free calcium elevation was also specific, no change being observed after incubation with equivalent concentrations of L-glucose or mannitol. This glucose effect was also dependent on extracellular calcium and pH, since these calcium changes were inhibited in an acidotic or a calcium-free medium, or by the competitive calcium antagonist lanthanum. We conclude that ambient glucose concentrations within clinically observed limits may alter cellular calcium ion homeostasis in vascular smooth muscle cells. We suggest that these cellular ionic effects of hyperglycemia may underlie the predisposition to hypertension and vascular diseases among diabetic subjects and/or those with impaired glucose tolerance.
Persistent Anaemia in a Breast-fed Infant with Erythroblastosis Foetalis
Authors: R. Davies
Journal: BMJ (1947)

Persistent Anaemia in a Breast-fed Infant with Erythroblastosis FoetalisThe fact that anti-Rh agglutinins may be excreted in the breast milk is becoming increasingly well recognized, but the danger of continued breast-feeding to infants suffering from erythroblastosis foetalis is not comnronly realized.The following case may be of interest in view of the fact that the haemolytic pro- cess was probably maintained by the baby receiving anti-Rh agglutinins via the mother's milk. CASE REPORTFemale child, born May 24, 1946.Normal pregnancy and labour.Birth weight 8 lb. (3.6 kg.).Slightly jaundiced on day of birth, and this increased in intensity until she was admitted to hospital four days later.Her parents are healthy.They have one other -child, aged 6+ years, who was quite normal as a baby.There was a still- birth 21 years ago; the cause of this is unknown.No miscarriages.
Molecular Convergence of Infrared Vision in Snakes
Authors: Shozo Yokoyama, Ahmet Altun, Dale F. DeNardo
Journal: Molecular Biology and Evolution (2010)

It has been discovered that the transient receptor potential ankyrin 1 (TRPA1) proteins of Boidae (boas), Pythonidae (pythons), and Crotalinae (pit vipers) are used to detect infrared radiation, but the molecular mechanism for detecting the infrared radiation is unknown. Here, relating the amino acid substitutions in their TRPA1 proteins and the functional differentiations, we propose that three parallel amino acid changes (L330M, Q391H, and S434T) are responsible for the development of infrared vision in the three groups of snakes. Protein modeling shows that the three amino acid changes alter the structures of the central region of their ankyrin repeats.
Brain's Diseases of the Nervous System
Authors: Michael J. Aminoff
Journal: JAMA (1994)

This handsome volume has evolved in its tenth edition from a single-authored work to include contributions from 11 other distinguished British neurologists as well as from John Walton, who serves as editor of the new edition. The intended audience is stated in neither Lord Brain's preface to the first edition nor Lord Walton's preface to the current one, but the book's size will be daunting to medical students and general physicians, and it is likely to appeal as a reference work primarily to neurologists. The 24 chapters that constitute the book cover most of the important aspects of clinical neurology in a thorough and comprehensive manner, but the balance is sometimes uneven. For example, although pain is discussed as it occurs in various neurological disorders, it is considered as a topic of its own in only two pages, with no real discussion of the management of pain syndromes, despite the
A Simplified Method for the Resolution of the Orthogonal Electrocardiogram
Authors: HUBERT V. PIPBERGER, C. ROBERT WOOD
Journal: Circulation Research (1958)

The question as to whether unipolar precordial electrocardiographic leads provide clinical information not contained in a 3-lead orthogonal electrocardiogram remains unanswered. A simple, inexpensive switching-type resolver was designed for the investigation of this problem.
Neutrophil function response to aerobic and anaerobic exercise in female judoka and untrained subjects
Authors: Baruch Wolach, Bareket Falk, Ronit Gavrieli, Einat Kodesh, Alon Eliakim
Journal: British Journal of Sports Medicine (2000)

Objectives —Recent studies have indicated reduced immunity in trained athletes. Aim —To assess the effects of aerobic and anaerobic exercise on the phagocytic process in 18–26 year old trained female judoka (n = 8) and untrained controls (n = 7). Methods —Each subject participated randomly in two different testing sessions (aerobic, 20 minutes of treadmill running at 70–80% of maximal heart rate; anaerobic, Wingate anaerobic test). Venous blood samples were drawn before, immediately after, and 24 hours after each session. Results —There were no significant differences in basal values of net chemotaxis (chemotaxis − random migration), bactericidal activity, and superoxide anion release between the judoka and the untrained women. There was a significant decrease in net chemotaxis 24 hours after the aerobic exercise in both the judoka (from 64 (19) to 39 (13) cells/field, p&lt;0.02) and the untrained controls (from 60 (7) to 47 (12) cells/field, p&lt;0.05). Bactericidal activity and superoxide anion release did not change significantly after aerobic exercise in either group. There were no significant changes in net chemotaxis, bactericidal activity, and superoxide anion release after anaerobic exercise in either the judoka or untrained women. Conclusions —The decrease in net chemotaxis after aerobic, but not after anaerobic, exercise, suggests that net chemotaxis is affected by the combination of exercise intensity and duration, and not by the exercise intensity itself. Similar effects of both exercise sessions in the judoka and the untrained women suggest that training had no effect on neutrophil function response to aerobic and anaerobic exercises.
Selective Transduction of Murine Myelomonocytic Leukemia Cells (WEHI-3B) with Regular and RGD-Adenoviral Vectors
Authors: Javier Garcıa-Castro, José Carlos Segovia, Félix Garcıa-Sánchez, Rosa Lillo, Jesús Gómez-Navarro, David T. Curiel, Juan A. Bueren
Journal: Molecular Therapy (2001)

On the basis of the susceptibility of normal myelomonocytic cells to adenoviral vectors, we have studied the possibility of selectively transducing myelomonocytic murine leukemic cells (WEHI-3B) with regular (Reg-Ad) and genetically modified (RGD-Ad) adenoviral vectors. An 8-h incubation of WEHI-3B cells with 100 pfu of Reg-Ad vectors/cell resulted in the whole population becoming positive for transgene expression. Under identical conditions of infection, 20–30% of mouse bone marrow (BM) cells were positive for the transgene. When RGD-Ad vectors were used, a brief exposure (10 min) of WEHI-3B cells to 150 pfu of the virus/cell was enough for 100% of the leukemia cells to become positive for the marker transgene (EGFP). Under these conditions, only 15–20% of BM cells and of primitive hematopoietic progenitors (Lin−Sca-1+ cells) became EGFP+, indicating an improved selectivity of the vectors for the leukemic cells. The incubation of WEHI-3B but not normal BM cells with soluble fiber protein (FP) inhibited the infection with Reg-Ad. The use of the RGD-Ad bypassed the FP-CAR interaction required for the transduction of WEHI-3B cells with Reg-Ad, suggesting that the abrogation of this requirement accounts for the improved infectivity of these leukemic cells and for the selectivity of RGD-Ad in targeting WEHI-3B leukemia cells.
High CD8+ lymphocyte dose in the autograft predicts early absolute lymphocyte count recovery after peripheral hematopoietic stem cell transplantation
Authors: Elias Hallack Atta, Alexandre Mello de Azevedo, Angelo Maiolino, Cláudia Júlia Bruzzi Porto Coelho, Silvia Maria Patiño Sarcinelli, Cláudia de Alvarenga Máximo, Vera Lúcia Neves Marra
Journal: American Journal of Hematology (2008)

Early lymphocyte recovery (ELR) after autologous peripheral hematopoietic stem cell transplantation (ASCT) is an independent predictor for survival in patients with hematological and non-hematological cancers. Sixty-five ASCT for hematological cancers were retrospectively analyzed to identify the factors associated with ELR and to assess the impact of different mobilization regimens on the pre-collection absolute lymphocyte count (ALC). The CD8+ lymphocyte dose in the autograft and the pre-mobilization ALC were independently associated with ELR (P < 0.001 and P = 0.008, respectively). CD8+ lymphocyte doses higher than 0.1 x 10(9)/kg were strongly associated with ELR [P < 0.001, odds ratio 25.22, 95% confidence interval (CI) 4.98-127.69] and this cutoff may be used to predict ELR (P = 0.001, area under the curve 0.75, 95% CI 0.62-0.88). Mobilization with granulocyte colony-stimulating factor (G-CSF) alone, the pre-collection ALC and the number of apheresis sessions were independently associated with the CD8+ lymphocyte dose (P = 0.04, P = 0.001, and P < 0.001, respectively). The number of aphereses was the variable with the strongest correlation to the CD8+ lymphocyte dose (r(s) = 0.68, P < 0.001). Median pre-mobilization ALC was higher than pre-collection ALC in the subgroup of patients without ELR mobilized with chemotherapy followed by G-CSF (1090 vs. 758 lymphocytes/microL; P < 0.001). This reduction was not significant in the subgroup with ELR mobilized with chemotherapy plus G-CSF (1920 vs. 1539/microL, respectively; P = 0.23). These results suggest that the CD8+ lymphocyte dose in the autograft is critical for ELR after ASCT and also demonstrates that mobilization with chemotherapy followed by G-CSF significantly decreases the pre-collection ALC, especially in patients with low pre-mobilization ALC.
Clinical Crossroads: An 88-Year-Old Woman Facing the End of Life
Authors: Valery A. Portnoi
Journal: JAMA (1997)

To the Editor.  —As a practicing geriatrician, I enjoyed reading Dr Lynn's discussion of Mrs J, an 88-year-old woman at the end of life. 1 I have under my care a 92-year-old woman with strikingly similar conditions, ie, severe aortic stenosis, coronary artery disease, and congestive heart failure (CHF). But, in contrast to Mrs J, 2 years ago my patient reversed her initial decision to have hospice care and underwent 2 balloon valvuloplasties.  It appears that Mrs J 1 year before discussion was ready for more aggressive treatment. Otherwise why would she consent to cardiac catheterization? Open heart surgery was not a good treatment option, as Lynn commented. But what about valvuloplasty? A wide range of invasive treatment options can be successful, even in very elderly patients. 2   Regardless of decisions regarding invasive procedures or surgery, medical management of CHF should be optimized for the patient discussed by Lynn. Angiotensin-converting enzyme inhibitors are a
Points from letters: Hearing aids for the elderly
Authors: M Anwar
Journal: BMJ (1975)

NHS family planning services SIR,-In the BM7 (19 July, p 185) it is re- ported that "the profession's negotiators [our italics] and the DHSS have agreed a scheme for the provision of family planning services through the hospital service, for all FP work, whether of medical or social origin."We are astonished that there has been, as yet, minimal medical or public reaction to this retrograde proposal.It is the feeling of the undersigned staff of the obstetrical and gynaecological department in Aberdeen that this scheme is indisputably bad.The reasons for its introduction are far from obvious and the advantages in terms of patient care are difficult to define.Furthermore, it may turm out to have a dangerously disruptive effect among different grades of staff in many gynaecological and anaesthetic departments, including theatre staff and porters.It seems ludicrous for a health service short of money in a time of rapid inflation to put out extra money to its highest paid workers.This is all apart from the questionable morality of the scheme and the inevitable difficulties it will present in the counselling of patients who seek unbiased family planning advice.
Serum Alkaline Phosphatase Isoenzymes In Sickle Cell Anemia
Authors: Jerome I. Brody
Journal: JAMA (1975)

Alkaline phosphatase isoenzymes in sera from patients with sickle cell anemia were separated by electrophoresis on starch gel. Physical and biochemical criteria identified bone alkaline phosphatase as the principal, although not necessarily the sole, enzyme fraction that increases during symptomatic sickle cell crises. Moreover, there appeared to be concordance between crisis severity, serum levels of alkaline phosphatase, and isoenzyme patterns; electrophoretic and biochemical abnormalities could be detected even when the patients were asymptomatic. The present data suggest that the serum alkaline phosphatase level may be an additional indicator of the degree, frequency, and persistence of tissue injuries that occur in sickle cell anemia. (<i>JAMA</i>232:738-741, 1975)
Gold colitis induced by auranofin treatment of rheumatoid arthritis: case report and review of the literature.
Authors: H E Langer, G Hartmann, G Heinemann, K Richter
Journal: Annals of the Rheumatic Diseases (1987)

A case of ulcerative colitis occurred during treatment of rheumatoid arthritis with the new oral gold preparation auranofin after a cumulative dose of 2160 mg. A barium enema showed loss of mucosal pattern and a rectal biopsy disclosed deep erosions, mucosal inflammation, and crypt abscesses. Precipitates of gold were seen in the periglandular stroma. On electron microscopy the gold deposits seemed to be identical to granules described in gold nephropathy. As the extrapolated serum gold level was within the normal range at the onset of the complication, the morphological findings suggested a local toxicity of the drug. The patient recovered within 14 days of withdrawal of auranofin and the start of therapy with sulphasalazine and steroids. A review of the published work shows that the previously reported mortality in gold colitis of 40% has decreased in recent years. The causes of this decrease may be both the earlier diagnosis of gold colitis and the improved intensive care of its severe complications.
"Mini-Stroke" From Phone Call
Authors: Rebecca Voelker
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Meta-Analysis for Explanation: A Casebook
Authors: Bert Spilker
Journal: JAMA (1993)

<b>Cross Design Synthesis: A New Strategy for Medical Effectiveness Research,</b>by US General Accounting Office (GAO/PEMD-92-19), 121 pp, paper, $2, Washington, DC, US General Accounting Office, 1992. Meta-analysis has generally been accepted as a valid method to address certain clinical questions that are evaluated in clinical trials. A number of researchers are expanding the scope and depth of this technique through such approaches as cumulative meta-analysis, in which the technique is repeated after each new clinical trial of a certain type is completed until the resulting effect reaches a predetermined level of significance. <i>Meta-Analysis for Explanation: A Casebook</i>is a recent book with eight authors, as well as four other chapter contributors. Nonetheless, the eight have created a book of great depth, which is essential reading for people interested in how this methodology may be used. This book will be of greatest interest to researchers in the social sciences, in which
Mast Cell Carboxypeptidase and Angiotensin-Converting Enzyme (ACE) as Serum Markers of Susceptibility to Severe Food Allergic Reactions
Authors: H.S. Whitworth, S. Leach, X. Zhou, K. Bodey, L. Lau, M. Erlewyn-Lajeunesse, J.S. Lucas, A.F. Walls
Journal: Journal of Allergy and Clinical Immunology (2010)
Thrombolysis in myocardial infarction (TIMI) trial—Phase I: Hemorrhagic manifestations and changes in plasma fibrinogen and the fibrinolytic system in patients treated with recombinant tissue plasminogen activator and streptokinase
Authors: A.Koneti Rao, Craig Pratt, Andrew Berke, Allan Jaffe, Ira Ockene, Theodore L Schreiber, William R Bell, Genell Knatterud, Thomas L Robertson, Michael L Terrin
Journal: Journal of the American College of Cardiology (1988)
XXI. Medical Practice: Specialization
Authors: Lester S. King
Journal: JAMA (1984)

Shortly after the middle of the 19th century, specialization in medicine increased greatly. It formed part of the vast expansion of knowledge and the improvement in patient care that characterized the era. However, there also developed many internal strains whose study provides an excellent approach to medical practice and the sociology of medicine. Central to the story of specialization is the<i>consultant</i>, who could help the general practitioner with a difficult case. In the 17th and 18th centuries, in Great Britain, the physician, who held an MD degree, would act as consultant for the apothecary, who did not have university training.<sup>1</sup>In the United States, even though the distinction of physician and apothecary did not obtain, the consultation always had a prominent part in medical practice. By virtue of training and experience the consultant was qualified to give advice. When called in consultation he could unearth new evidence, or
Industry steps up efforts to develop avian flu vaccine
Authors: John Zarocostas
Journal: BMJ (2005)

Four prototype vaccines against avian flu in humans are expected to be submitted to regulatory authorities for approval before the end of 2006, industry representatives have said.

Dr Lee Jong-wook, director general of the World Health Organization, told a conference on avian and human influenza in Geneva last week: “A universal non-specific pandemic vaccine may be the ultimate protective solution for human influenza.”

However, the amount of flu vaccine that could be produced in the event of a pandemic outbreak is still difficult to estimate, because of the lack of results from clinical trials and the time lag from development …
On the Psychostasis of Ulster
Authors: H.D. Rankin
Journal: Psychotherapy and Psychosomatics (1971)

Considering the richness in symbolism of Ulster Protestant folk culture, which is a functional antitype of the corresponding Catholic culture, it is argued that the attitudes of Ulster Protestants are characterised by homoeostatic resistance to the threat of alteration in the balance of internal and external forces which maintain an archaistic 17th century socio-religious structure; it is suggested that there is evidence of 'splitting' of parent image; ambivalence and incest fear in relation to Ireland as maternal entity; UCS factors very markedly influence attitudes to death, time, and society.