tbuckley/cabot-search huggingface dataset:
Clinical Characteristics of Dialysis Patients With Acute Myocardial Infarction in the United States
Authors: Charles A. Herzog, Kathee Littrell, Cheryl Arko, Paul D. Frederick, Martha Blaney
Journal: Circulation (2007)

Acute myocardial infarction (AMI) is catastrophic for dialysis patients. This study set out to determine the clinical characteristics of dialysis patients hospitalized for AMI in the United States.This retrospective cohort study used data from the US Renal Data System (USRDS) database (n=1,285,177) and the third National Registry of Myocardial Infarction (NRMI 3) (n=537,444). AMI hospitalizations from April 1, 1998, through June 30, 2000, were identified using International Classification of Diseases, 9th edition, clinical modification, codes 410, 410.x, 410.x0, and 410.x1. The 9418 unique dialysis patients identified with AMI hospitalizations in the USRDS database were cross-matched with the NRMI registry, creating a cohort for analysis that consisted of 3049 matching patients. Clinical characteristics of dialysis and nondialysis (n=534,395) AMI patients were compared by use of the chi2 test. Of clinical significance, 44.8% of dialysis patients were diagnosed as not having acute coronary syndrome on admission, versus 21.2% of nondialysis patients; 44.4% presented with chest pain, versus 68.3% of nondialysis patients; and 19.1% had ST elevation, versus 35.9% of nondialysis patients. Cardiac arrest was twice as frequent for dialysis patients (11.0% versus 5.0%), and in-hospital death was nearly so (21.3% versus 11.7%). In a logistic regression model, the odds ratio for in-hospital death for dialysis versus nondialysis patients was 1.498 (95% CI, 1.340 to 1.674).Dialysis patients hospitalized for AMI differ strikingly from nondialysis patients, which possibly explains their poor outcomes. Intensive efforts for early, accurate recognition of AMI in dialysis patients are warranted.
Atypical prediagnosis Epstein-Barr virus serology restricted to EBV-positive Hodgkin lymphoma
Authors: Lynn I. Levin, Ellen T. Chang, Richard F. Ambinder, Evelyne T. Lennette, Mark V. Rubertone, Risa B. Mann, Michael Borowitz, Edward G. Weir, Susan L. Abbondanzo, Nancy E. Mueller
Journal: Blood (2012)
STENT THROMBOSIS AND BLEEDING COMPLICATIONS IN DIABETIC PATIENTS ON LONG-TERM (5 YEARS) DUAL ANTIPLATELET TREATMENT FOLLOWING 1ST GENERATION DRUG-ELUTING STENT IMPLANTATION: COMPARISON WITH PATIENTS ON SINGLE ANTIPLATELET TREATMENT
Authors: Vassilis A. Voudris, Panagiotis Karyofillis, Constantinos Doulaptsis, Ioannis Moukas, Sofia Thomopoulou, Dennis V. Cokkinos
Journal: Journal of the American College of Cardiology (2012)
Extrapulmonary tuberculous abscess in chronic lymphocytic leukaemia (CLL) treated with fludarabine: Case report and review of literature
Authors: W.H. Leung, S.F.D. Tsang, C.S. Chim
Journal: American Journal of Hematology (2005)

To the Editor: A 58-year-old man presented 7 years ago with Binet stage II of CLL.Because of rapidly rising lymphocyte count of 46.9 Â 10 9 /L [normal range: (1.5-4.0)Â 10 9 /L], he was treated with FND (fludarabine, mitoxantrone, dexamethasone), which resulted in recurrent neutropenia [1].Six weeks after the fourth cycle of chemotherapy, he developed fever of unknown origin.Complete blood count showed hemoglobin 9.1 g/dL, platelets 58 Â 10 9 /L, leucocyte count 7.7 Â 10 9 /L [normal range: (4-11) Â 10 9 /L].Differential count showed neutrophils 2.3 Â 10 9 /L [normal range: (2-7.5)Â 10 9 /L], lymphocytes 5.4Â 10 9 /L [normal range: (1.5-4)Â 10 9 /L], and absence of monocytes, eosinophils, and basophils.CD4 count was 0.2 Â 10 9 /L with a reversed CD4/CD8 ratio of 0.45:1.Serum IgG measured 346 mg/dL (normal >819 mg/dL), IgA 14 mg/dL (normal >70 mg/dL), and IgM 13 mg/dL (normal >55 mg/dL).Eight days after admission, he developed painful left thigh swelling.Computed tomography revealed hypodensities at the left rectis femoris, vastus intermedius, and vastus lateralis, which yielded pus on drainage (Fig. 1).Histological examination of tissue adjacent to the abscess revealed abundant Ziehl-Neelsen-positive mycobacteria, and subsequent culture confirmed Mycobacterium tuberculosis.
Natural Regulatory T Cell Dysfunction in Subjects with Common Variable Immunodeficiency Complicated by Autoimmune Disease is associated with activation of the AkT-mTOR pathway
Authors: G.P. Yu, S.W. Berquist, J.J. Huang, J. Martinez, E.G. Hoyte, C.T. Vanichsarn, K.C. Nadeau
Journal: Journal of Allergy and Clinical Immunology (2009)
P247 SIMVASTATIN ATTENUATES FIBROSIS IN A NEW RODENT NASH MODEL WITHIN THE METABOLIC SYNDROME
Authors: R. Schierwagen, L. Maybüchen, S. Klein, K. Hiththejeti, D. Lütjohann, J. Plat, C.P. Strassburg, G. Nickenig, T. Sauerbruch, S. Zimmer, J. Trebicka
Journal: Journal of Hepatology (2014)
Comparative assessment of regional left atrial perfusion by laser Doppler and radionuclide microsphere techniques
Authors: B. D Hoit, R. A Walsh, Y. Shao, M. Gabel, R. Millard
Journal: Cardiovascular Research (1993)

The aim was to study the relation between left atrial microcirculatory flux, using laser Doppler flowmetry (LDF), and blood flow, using radiolabelled microspheres (MS).Studies were done in five anaesthetised dogs. LDF probes were sewn to the appendage and body of the left atrium. Radionuclide spheres (15 microns) were used to quantitate blood flow at baseline, and during atrial pacing at 3.5 Hz, atrial fibrillation, and intravenous adenosine infusion (1 mg.kg-1 x min-1).In the left atrial body, both MS and LDF perfusion increased significantly during pacing and adenosine infusion; only LDF registered significant increases during atrial fibrillation. In the left atrial appendage, MS flow failed to increase significantly with any intervention and LDF perfusion increased significantly only during atrial fibrillation. There was a significant but weak correlation (r = 0.36, p < 0.05) between LDF and MS when data from all sample sites (n = 40) were compared, but good correlation when only baseline and pacing data were compared (r = 0.72, p = 0.0004, n = 20). In four additional dogs with heart failure [mean left atrial pressure 25.3(SD 7.4) mm Hg] produced by three weeks of rapid right ventricular pacing, flux values at baseline were increased significantly compared to control dogs and the responses registered by LDF to pacing, atrial fibrillation, and adenosine infusion were attenuated markedly.(1) Microcirculatory flux detected by LDF can identify the direction, and to a lesser extent, the magnitude of changes in regional atrial perfusion; and (2) LDF may be useful in identifying abnormalities of vasodilator reserve that accompany chronic left atrial myocardial dysfunction.
Isolation of Rubella Virus from Abortion Material
Authors: K. M. Thompson, J. OH. Tobin
Journal: BMJ (1970)

Rubella virus was isolated from the fetus or products of conception in 29 out of 32 cases (91%) terminated because of clinical maternal rubella proved or supported by laboratory findings in the first trimester of pregnancy. Virus was isolated from similar material from only 3 out of 19 (16%) other clinical cases of rubella in which the laboratory findings were inconclusive or against the diagnosis or in which no laboratory tests were done. Virus was found in the amniotic fluid if the fetus was infected and there was no evidence that the placenta was any real barrier to fetal infection.
Concentrations of high density lipoprotein cholesterol, triglycerides, and total cholesterol in ischaemic heart disease.
Authors: S. J. Pocock, A. G. Shaper, A. N. Phillips
Journal: BMJ (1989)

OBJECTIVE--To assess the roles of serum concentrations of total cholesterol, high density lipoprotein cholesterol, and triglycerides in predicting major ischaemic heart disease. DESIGN--Men recruited for the British regional heart study followed up for a mean of 7.5 years. SETTING--General practices in 24 British towns. PATIENTS--7735 Middle aged men. END POINT--Predictive value of serum concentrations of lipids. MEASUREMENTS AND MAIN RESULTS--At initial screening serum concentrations of total cholesterol, high density lipoprotein cholesterol, and triglycerides were determined from non-fasting blood samples. Altogether 443 major ischaemic heart disease events (fatal and non-fatal) occurred during the study. Men in the highest fifth of the distribution of total cholesterol concentration (greater than or equal to 7.2 mmol/l) had 3.5 times the risk of ischaemic heart disease than did men in the lowest fifth (less than 5.5 mmol/l) after adjustment for high density lipoprotein cholesterol concentration and other risk factors. Men in the lowest fifth of high density lipoprotein cholesterol concentration (less than 0.93 mmol/l) had 2.0 times the risk of men in the highest fifth (greater than or equal to 1.33 mmol/l) after adjustment for total cholesterol concentration and other risk factors. Men in the highest fifth of triglyceride concentration (greater than or equal to 2.8 mmol/l) had only 1.3 times the risk of those in the lowest fifth (less than 1.08 mmol/l) after adjustment for total cholesterol concentration and other risk factors; additional adjustment for high density lipoprotein cholesterol concentration made the association with ischaemic heart disease disappear. CONCLUSIONS--Serum concentration of total cholesterol is the most important single blood lipid risk factor for ischaemic heart disease in men. High density lipoprotein cholesterol concentration is less important, and triglyceride concentrations do not have predictive importance once other risk factors have been taken into account.
Ibuprofen-Induced Meningitis in Systemic Lupus Erythematosus
Authors: Herbert L. Widener
Journal: JAMA (1978)

A patient with systemic lupus erythematosus had chills, fever, and headache on four separate occasions after ibuprofen ingestion. One such episode was accompanied by cerebrospinal fluid findings compatible with meningitis. Drug rechallenge under controlled conditions established the relationship between ibuprofen ingestion and meningitis. (<i>JAMA</i>239:1062-1064, 1978)
New mechanisms of action with fungicidal antifungals
Authors: A. RASHID
Journal: British Journal of Dermatology (1996)

Morphological modifications of growth forms of dermatophyte fungi, arthroconidia and germ tubes exposed to terbinafine incorporated in the stratum corneum were studied by scanning and transmission electron microscopy. Changes observed in arthroconidial morphology included pores and erosions present in the cell wall, with layers peeling off. The cell membrane was destroyed. Dilated vacuoles and small electron-dense areas were evident in the arthroconidial cytosol. Although germination was partially arrested, inhibition of hyphal extension was seen on all body sites examined. Germ tubes were susceptible to terbinafine, with pores appearing along their length and collapsed hyphae seen following exposure to the drug. This study suggests that the outer and inner layers of the arthroconidial cell wall are the initial targets of terbinafine action, followed by alterations to the cytosol and intracellular organelles.
Relations between desire for early death, depressive symptoms and antidepressant prescribing in terminally ill patients with cancer
Authors: E Tiernan, P Casey, C O'Boyle, G Birkbeck, M Mangan, L O'Siorain, M Kearney
Journal: Journal of the Royal Society of Medicine (2002)

Some patients with advanced cancer express the wish for an early death. This may be associated with depression. We examined the relations between depressive symptoms and desire for early death (natural or by euthanasia or physician-assisted suicide) in 142 terminally ill patients with cancer being cared for by a specialist palliative care team. They completed the Hospital Anxiety and Depression Scale questionnaire and answered four supplementary questions on desire for early death. Only 2 patients expressed a strong wish for death by some form of suicide or euthanasia. 120 denied that they ever wished for early release. The desire for early death correlated with depression scores. Depressive symptoms were common in the whole group but few were on antidepressant therapy. Better recognition and treatment of depression might improve the lives of people with terminal illness and so lessen desire for early death, whether natural or by suicide.
Risk of cancer in patients with scleroderma
Authors: J E Pearson
Journal: Annals of the Rheumatic Diseases (2003)

T he first report linking cancer with scleroderma (Scl) was 50 years ago when a case of alveolar cell carcinoma was described. 1Since then there have been several further case reports and series linking Scl with cancer at various sites. 2The sites of cancer most frequently reported are the lung 3 4 and breast 5 (perhaps reflecting their prevalence in the general population), but cancers at other sites have also been reported. 2 6 In this issue of the Annals there is a report of an Australian population study on Scl and cancer. 7The authors showed a doubling in the risk of all cancers over an average six year follow up period, with the lung being the site at greatest risk.It is thus timely to consider all the evidence suggesting this association is real and then explore some of the possible underlying explanations.
Chronic Thrombus Detection With In Vivo Magnetic Resonance Imaging and a Fibrin-Targeted Contrast Agent
Authors: Marc Sirol, Valentin Fuster, Juan J. Badimon, John T. Fallon, Jean-François Toussaint, Zahi A. Fayad
Journal: Circulation (2005)

Arterial thrombosis plays a critical role in acute coronary syndromes and stroke. Therefore, the ability to detect thrombus in vivo has a significant clinical implication. Magnetic resonance imaging (MRI) has shown promise in noninvasive thrombus detection. However, thrombus characterization and age definition remain difficult. We sought to evaluate the use of a fibrin-targeted peptide (EP-2104R) for MR thrombus detection and to compare this modality with non-contrast-enhanced (NCE) MRI and with Gd-DTPA injection at various ages and time points after thrombus generation.Carotid artery thrombosis was induced by external injury and stasis in 18 rabbits. T1-weighted MRI was performed before and after contrast agent injection, within 6 hours of thrombus induction, at 48 hours, at 1 week, and every week up to 8 weeks after injury. Correlation with histopathology was performed. The fibrin-targeted contrast agent accurately detected all thrombi, regardless of their size, location, and age. Although thrombus signal intensity after injection decreased with thrombus age (P<0.001), enhancement at 8 weeks was still present. Gd-DTPA injection was not associated with an improvement of thrombus detection. EP-2104R was superior to both NCE and Gd-DTPA injection (P<0.001). Histopathologic examination showed thrombus organization over time. Fibrin was gradually replaced by fibrous tissue. A strong correlation was found between thrombus enhancement and collagen content of the organizing thrombus with time (R=-0.89; P<0.001).In an experimental animal model of carotid thrombosis, we have demonstrated the superiority of a fibrin-targeted MR contrast agent for in vivo detection of chronic or organized thrombus, compared with NCE MRI and Gd-DTPA injection.
Activating Transcription Factor 2 Mediates Matrix Metalloproteinase-2 Transcriptional Activation Induced by p38 in Breast Epithelial Cells
Authors: Hyun Song, Sung Hwan Ki, Sang Geon Kim, Aree Moon
Journal: Cancer Research (2006)

Abstract Mounting evidence suggests a role for matrix metalloproteinase (MMP)-2 in the malignant progression of breast cancer cells. We showed previously that H-Ras, but not N-Ras, induced invasion of MCF10A human breast epithelial cells through Rac-MKK3/6-p38 pathway resulted in MMP-2 up-regulation. Activation of p38 pathway by MKK6 caused a selective up-regulation of MMP-2. In this study, we aimed to elucidate the transcriptional regulation of MMP-2 by p38 pathway leading to the invasive phenotype of MCF10A cells. By using 5′ deletion mutant constructs of MMP-2 promoter, we showed that deletion of the region containing activator protein-1 (AP-1) site caused the greatest reduction of MMP-2 promoter activity both in MKK6- and H-Ras-activated MCF10A cells, suggesting that the AP-1 binding site is critical for the MMP-2 promoter activation. DNA binding and transcriptional activities of AP-1 were increased by MKK6 or H-Ras as evidenced by electrophoretic mobility shift assay and luciferase assay using an AP-1-driven plasmid. By doing immunoinhibition assay and chromatin immunoprecipitation assay, we revealed the activating transcription factor (ATF) 2 as a transcription factor for MMP-2 gene expression through binding to the functional AP-1 site. Activation of ATF2, which depended on p38 activity, was crucial for MMP-2 promoter activity as well as induction of invasive and migrative phenotypes in MCF10A cells. This is the first report revealing ATF2 as an essential transcription factor linking MKK3/6-p38 signaling pathway to MMP-2 up-regulation, providing evidence for a direct role of ATF2 activation in malignant phenotypic changes of human breast epithelial cells. (Cancer Res 2006; 66(21): 10487-96)
Requirement for Interaction of PI3-Kinase p110α with RAS in Lung Tumor Maintenance
Authors: Esther Castellano, Clare Sheridan, May Zaw Thin, Emma Nye, Bradley Spencer-Dene, Markus E. Diefenbacher, Christopher Moore, Madhu S. Kumar, Miguel M. Murillo, Eva Grönroos, Francois Lassailly, Gordon Stamp, Julian Downward
Journal: Cancer Cell (2013)

Highlights•Inducible disruption of PI3-kinase p110α interaction with RAS was modeled in mice•Blocking RAS/p110α interaction in established lung tumors causes partial regression•Blocking RAS/p110α binding has effects similar to p110α deletion on tumor regression•Coordinate MEK inhibition is required for major regression of Kras mutant lung cancerSummaryRAS proteins directly activate PI3-kinases. Mice bearing a germline mutation in the RAS binding domain of the p110α subunit of PI3-kinse are resistant to the development of RAS-driven tumors. However, it is unknown whether interaction of RAS with PI3-kinase is required in established tumors. The need for RAS interaction with p110α in the maintenance of mutant Kras-driven lung tumors was explored using an inducible mouse model. In established tumors, removal of the ability of p110α to interact with RAS causes long-term tumor stasis and partial regression. This is a tumor cell-autonomous effect, which is improved significantly by combination with MEK inhibition. Total removal of p110α expression or activity has comparable effects, albeit with greater toxicities.
Protection of Skin from Germicidal Ultraviolet Radiation in the Operating Room by Topical Chemicals
Authors: John A. Parrish, Madhu A. Pathak, Thomas B. Fitzpatrick
Journal: New England Journal of Medicine (1971)

MERCURY-arc lamps emitting short-wavelength ultraviolet light (254 mμ) are widely used for their microbicidal effect in tissue-culture laboratories, food-preparation areas, hospital ventilation systems and operating rooms.1 , 2 Their use in operating rooms, however, has been somewhat limited because of the known erythema and desquamation; hyperpigmentation can occur when human skin is exposed to these wavelengths.3 , 4 To avoid these damaging effects on the skin, as well as a potential carcinogen effect of the radiation,5 operating-room personnel must wear cumbersome gear that leaves no cutaneous surface exposed. Commercially available lotions designed to minimize or block the sunburn reaction and permit tanning without discomfort . . .
How well does 3-dimensional echocardiographic quantification of dysfunctional left ventricular mass reflect actual anatomic infarct mass? Experimental studies
Authors: Jiefen Yao, Qi-Ling Cao, Alain Delabays, Giuseppina Magni, Philippe Acar, Cleo Laskari, Navroz Masani, Mark Aronovitz, Mani Vannan, Natesa Pandian
Journal: Journal of the American College of Cardiology (1996)
National Asthma Education and Prevention Program Working Group Report on the Cost Effectiveness of Asthma Care
Authors: Sean Sullivan, Anne Elixhauser, A. Sonia Buist, Bryan R. Luce, John Eisenberg, Kevin B. Weiss
Journal: American Journal of Respiratory and Critical Care Medicine (1996)

The cost effectiveness of asthma care is the first topic of the National Asthma Education and Prevention Program Task Force Report on the Cost Effectiveness, Quality of Care, and Financing of Asthma Care. This working group characterized the role of health economics in understanding optimal asthma management strategies. The report first reviews methods for economic evaluation of medical technologies, with a particular focus on cost-effectiveness analysis. Next, the report explores the nature and usefulness of several key asthma outcome measures, including clinical and symptom measures, measures of lung function, measures of functional status, and measures of health services utilization and cost. The working group also conducted a review of the literature on cost effectiveness of asthma patient education programs, pharmaceutical therapy, and a variety of alternative and adjunct interventions. The report concludes with recommendations for a standardized approach for economic evaluation study designs (e.g., common asthma outcomes, long-term follow-up, and studies with patients of different ages, socioeconomic statuses, and severity levels) and for an expansion in the number of such standardized asthma studies and cost-effectiveness analyses.
Identification of Genome-wide Copy Number Variations and a Family-based Association Study of Avellino Corneal Dystrophy
Authors: Joon Seol Bae, Hyun Sub Cheong, Ji-Yong Chun, Tae Joon Park, Ji-On Kim, Eun Mi Kim, Miey Park, Dong-Joon Kim, Eun-Ju Lee, Eung Kweon Kim, Jong-Young Lee, Hyoung Doo Shin
Journal: Ophthalmology (2010)
Use of Anticonvulsant Drugs
Authors: Fritz E. Dreifuss
Journal: JAMA (1979)

THE PAST decade has seen considerable changes in epilepsy management, to which the introduction of new anticonvulsant drugs has contributed. Unfortunately, the ideal drug, one that is long-acting, nonsedative, well-tolerated, useful against various types of seizures, and without a substantive effect on vital organs, while at the same time restoring the EEG to normal, does not exist. Drugs that have been introduced into the therapy of epilepsy in recent years have tended to have more specific actions against particular seizure types, and this has necessitated a more accurate identification and classification of the epilepsies (Table).<sup>1</sup>Thus, drugs useful against absence seizures are not useful in the treatment of complex partial seizures, which may closely mimic absence seizures, and this mandates the distinction between these different types of seizure phenomenons. The introduction of new drugs has been aided by the development of the science of biostatistics, resulting in improved study
Tolerability to nabumetone and meloxicam in patients with nonsteroidal anti-inflammatory drug intolerance
Authors: Alicia Prieto, Manuel De Barrio, Elena Martín, María Fernández-Bohórquez, Francisco Javier de Castro, Francisco Javier Ruiz, Teresa Herrero, Pilar Tornero, María Rubio
Journal: Journal of Allergy and Clinical Immunology (2007)