tbuckley/cabot-search huggingface dataset:
Deafness in Paget's Disease?
Authors: K. M. GOEBEL
Journal: Annals of Internal Medicine (1972)

Letters, Comments, and Corrections1 February 1972Deafness in Paget's Disease?K. M. GOEBEL, M.D., F. D. GOEBEL, M.D.K. M. GOEBEL, M.D.Search for more papers by this author, F. D. GOEBEL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-2-336_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The new aspect of Beethoven's deafness, recently introduced by Dr. Naiken (1), again raises the question of whether the morphological changes of the skull in Paget's disease can impair function of the cranial nerves.This theory provokes some comments. Neurological investigations of cranial nerves I to XII have been performed on 15 patients with Paget's disease of the bone confined to the skull (2). Nine men and six women, between 65 and 98 years of age, were examined at the neurosurgical outpatient clinic, Free University of Berlin, in 1968. The diagnosis was based on the skull X-ray...References1. NAIKEN V: Did Beethoven have Paget's disease of bone? Ann Intern Med 74:995-999, 1971 LinkGoogle Scholar2. GOEBEL K: Neurologische Untersuchungen der Hirnnerven bei Morbus Paget. Berlin, Free University Press, 1968 Google Scholar3. CLEMISBOYLESHARFORD JJE: The clinical diagnosis of Paget's disease of the temporal bones. Ann Otol Rhinol Laryngol 76:611-623, 1967 CrossrefMedlineGoogle Scholar4. SPARROWDUVAL NA: Hearing loss and Pagets disease. J Laryngol 81:601-611, 1967 CrossrefMedlineGoogle Scholar5. TAMARI M: Histopathologic changes of the temporal bone in Paget's disease. Ann Otol Rhinol Laryngol 51:70-208, 1942 CrossrefGoogle Scholar6. MARIELERI PA: Die Pagetsche Knochenkrankheit, in Handbuch der Neurologie, VOL. 4. Edited by LEWANDOWSKY M, Berlin, Julius Springer, 1913, p. 471 Google Scholar1. AEGERTERKIRKPATRICK EJ: Orthopedic Diseases, 3rd ed. Philadelphia, W. B. Saunders Co., 1968, p. 467 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Departments of Medicine Philipps University D-355 Marburg Federal Republic of Germany PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1972Volume 76, Issue 2Page: 336-336KeywordsBoneCranial nervesDeafnessOutpatient clinicsSkull Issue Published: 1 February 1972 PDF DownloadLoading ...
Points: Sexual dysfunction in Asian couples
Authors: D. Khoosal
Journal: BMJ (1986)

Dr. Butler claims that I have "further-tarnished the reputation of Chile," nd he recommends that "further interchange ofdoctors takes placeso.thatmore people -may appreciate the freedom enjoyed by medical staff there, thus destrying the.ppular nusconceptions represented by thisarticle."My artcle did inl actcontai a strong plea that the medical professiot should not ostracise Chile, and that more British doctors should consier -ex- changes there.Aisl said in the article, this *will-e helpful to the profession in Chile.Whether it wl achieve Dr Eutler's intention of helping "more people-to appreciate the f0eedonm enjoyed 0-by medical staff there, thus destroying popglar mis- conceptions as perpetuated by this article" is more than doubtful.
Neuronal Damage in Autoimmune Neuroinflammation Mediated by the Death Ligand TRAIL
Authors: Orhan Aktas, Alina Smorodchenko, Stefan Brocke, Carmen Infante-Duarte, Ulf Schulze Topphoff, Johannes Vogt, Timour Prozorovski, Susanne Meier, Venera Osmanova, Elena Pohl, Ingo Bechmann, Robert Nitsch, Frauke Zipp
Journal: Neuron (2005)
A pH modifier site regulates activity of the Na+:HCO3- cotransporter in basolateral membranes of kidney proximal tubules.
Authors: M Soleimani, G A Lesoine, J A Bergman, T D McKinney
Journal: Journal of Clinical Investigation (1991)

HCO3- exit across the basolateral membrane of the kidney proximal tubule cell is mediated via an electrogenic Na+:HCO3- cotransporter. In these experiments, we have studied the effect of internal pH on the activity of the Na+:HCO3- cotransport system in basolateral membrane vesicles isolated from rabbit renal cortex. Equilibrium thermodynamics predicts that in the presence of constant intravesicular concentration of Na+, an increasing concentration of HCO3- will be associated with an increasing driving force for Na+:HCO3- cotransport across the vesicles. Our experimental approach was to preequilibrate the membrane vesicles with 1 mM 22Na+ at pHi 6.8-8.0 and known concentrations of HCO3-. The vesicles were diluted 1:100 into Na(+)-free solution at pH 7.4 and the net flux of 22Na+ was assayed over 5 s. The results demonstrate that the net flux of Na+ was significantly higher at pHi 7.2 than pHi 8.0 despite much higher [HCO3-] at pHi 8.0. This suggests that an internal pH-sensitive site regulates the activity of the Na+:HCO3- cotransporter. This modifier site inhibits the cotransporter at alkaline pH despite significant base concentration and is maximally functional around physiologic pH. The combination of modifier sites on the luminal Na+/H+ exchanger and the basolateral Na+:HCO3- cotransporter should help maintain intracellular pH in a narrow range with changes in extracellular pH.
Nasal mucosal absorption of tetracosactrin as indicated by rise in plasma fluorogenic corticosteroids
Authors: J. Keenan, M. A. Chamberlain
Journal: BMJ (1969)

Tetracosactrin has been administered to six healthy dexamethasone-suppressed subjects by nasal insufflation. The pronounced increase of the plasma fluorogenic corticosteroids suggests that the peptide is well absorbed by this route.
Successful Treatment With Imatinib in a Patient With Chronic Eosinophilic Leukemia Not Otherwise Specified
Authors: Alessandra Iurlo, Nicola Stefano Fracchiolla, Valeria Ferla, Ramona Cassin, Enrico Gottardi, Alessandro Beghini, Umberto Gianelli, Orietta Spinelli, Agostino Cortelezzi
Journal: Journal of Clinical Oncology (2014)
The role of an accessory atrioventricular pathway in reciprocal tachycardia. Observations in patients with and without the Wolff-Parkinson-White syndrome.
Authors: H J Wellens, D Durrer
Journal: Circulation (1975)

To study the pathway of tachycardia in patients with the Wolff-Parkinson-White (WPW) syndrome and reciprocal tachycardias, results from intracavitary recordings and atrial and ventricular stimulation were reviewed in 71 patients with the WPW syndrome and 54 patients without pre-excitation. In all patients a reproducible tachycardia could be initated and terminated by appropriately timed electrical stimuli. The following findings were accepted as suggesting the participation of an accessory pathway in the tachycardia circuit: 1) no increase in ventriculo-atrial conduction (V-A C) time following ventricular stimuli given with increasing prematurity; 2) activation of right or left atrium (depending upon the location of the atrial end of the accessory pathway) prior to activation of atrium in the His bundle lead; 3) slowing of tachycardia following bundle branch block to the ventricle in which the accessory pathway inserts; 4) V-A C time of early stimuli on the ventricle during the tachycardia equal to or less than the V-A c time following QRS complexes during tachycardia; 5) inability to initiate tachycardia or slowing of tachycardia following the administration of drugs affecting the accessory pathway. Accepted as suggestive for atrioventricular (A-V) nodal re-entry were the following factors: 1) activation of atrium following initiation of tachycardia by a single atrial premature beat after activation of the bundle of His but before or simultaneous with ventricular activation in first and subsequent beats of tachycardia; 2) initiation of tachycardia following a gradual increase in V-A C time with the appearance of a His bundle electrogram in between the premature beat and retrograde atrial activation; 3) gradual increase in V-A C time with the appearance of a His bundle electrogram following ventricular premature beats given with increasing prematurity; 4) two-to-one block distal to the A-V node or His bundle with persistance of tachycardia. If only positive findings were accepted, 51 patients of the WPW group used their accessory pathway during tachycardia. In eight patients re-entry was confined to the A-V node. In the remaining 12 patients the mechanism was not clear. Of the patients not showing pre-excitation in A-V direction, 47 patients seemed to have their re-entry circuit in the A-V node, five patients used an accessory pathway in V-A direction, and in two patients the pathway of tachycardia could not be identified.
Combination Chemotherapy of Advanced Diffuse Histiocytic Lymphoma with the Six-Drug COP-BLAM Regimen
Authors: JEFFREY LAURENCE
Journal: Annals of Internal Medicine (1982)

A new multiple-drug protocol consisting of cyclophosphamide, vincristine, prednisone, bleomycin, doxorubicin, and procarbazine, known as COP-BLAM, was administered to 48 patients with stage III or IV diffuse histiocytic lymphoma. Twenty-four of the 33 previously untreated patients had a complete remission, and eight patients had a partial response. The median survival for all previously untreated patients has not yet been reached at 23 months. Median survival for complete responders has not yet been attained at 26 months, although survival of partial responders is 12.5 months. There were no patients with a complete response who had a central nervous system relapse. The COP-BLAM therapy is an easily administered outpatient program capable of inducing a high frequency of durable complete remissions in advanced diffuse histiocytic lymphoma, a malignancy formerly considered to have a poor prognosis.
C-reactive protein impairs hepatic insulin sensitivity and insulin signaling in rats: Role of mitogen-activated protein kinases
Authors: Liang Xi, Changting Xiao, Robert H.J. Bandsma, Mark Naples, Khosrow Adeli, Gary F. Lewis
Journal: Hepatology (2010)

Plasma C-reactive protein (CRP) concentration is increased in the metabolic syndrome, which consists of a cluster of cardiovascular disease risk factors, including insulin resistance. It is not known, however, whether CRP is merely a marker of accompanying inflammation or whether it contributes causally to insulin resistance. The objective of this study is to investigate the role that CRP may play in the development of insulin resistance. We examined the effect of single-dose intravenous administration of purified human (h)CRP on insulin sensitivity in Sprague-Dawley rats using the euglycemic, hyperinsulinemic clamp technique. hCRP was associated with impaired insulin suppression of endogenous glucose production with no reduction in peripheral tissue glucose uptake, suggesting that hCRP mediated insulin resistance in the liver but not extrahepatic tissues. We further assessed components of the insulin signaling pathway and mitogen-activated protein kinases (MAPKs) in the liver. Liver tissues derived from hCRP-treated rats showed reduced insulin-stimulated insulin receptor substrate (IRS) tyrosine phosphorylation, IRS/phosphatidylinositol 3-kinase (PI3K) association, and Akt phosphorylation, consistent with hCRP-induced impairment of hepatic insulin signaling. Furthermore, hCRP enhanced phosphorylation of extracellular signal-regulated kinase (ERK)1/2 and p38 MAPK as well as IRS-1 Ser(612) . Finally, we observed in primary cultured rat hepatocytes that U0126 (a selective inhibitor of MAPK/ERK kinase1/2) corrected hCRP-induced impairment of insulin signaling. hCRP plays an active role in inducing hepatic insulin resistance in the rat, at least in part by activating ERK1/2, with downstream impairment in the insulin signaling pathway.
Rupture of the Triceps Tendon
Authors: M. L. H. Lee
Journal: BMJ (1960)

INACTIVATION OF NICOTINAMIDECALJTOURNAL 197 useful mrthod for analysing the vitamin requirements of various organogenetic processes in the developing embryo, and it is interesting that the nicotinamide requirements of the embryo-mother system studied appeared to vary from one gestational day to another.This approach might profitably be extended to other compounds as well.3. Though the standard dose of 6-aminonicotinamide without protection produces marked weakness within 6 to 12 hours (Pinsky and Fraser, 1959), the two-hour treatment with 6-aminonicotinamide, followed by a protective dose of nicotinamide, does not produce any signs of distress in the mother.Nevertheless, this brief exposu-re is highly teratogenic in mice.4. Though it is unwise to extrapolate experimental findings in mice to human beings, our results emphasize the need for careful nutritional and metabolic studies of mother and cmbryo in normal pregnancies and in those that give risc to malformations.
A Phase II Study of Panitumumab Plus Irinotecan for Metastatic Colorectal Cancer Patients with Wild KRAS Exon 2, Resistant to Fluoropyrimidine, Oxaliplatin and Irinotecan in Japanese. (OGSG1001)
Authors: Hata Taishi, Yoshida Motoki, Taira Koichi, Sugimoto Naotoshi, Tokunaga Yukihiko, Kii Takayuki, Kuwakado Shin, Hasegawa Hiroko, Fukunaga Mutsumi, Kato Takeshi, Miyake Yasuhiro, Takeda Koji, Yoshinami Tetsuhiro, Daga Haruko, Sakai Daisuke, Shimokawa Toshio, Kurokawa Yukinori, Satoh Taroh, Tsujinaka Toshimasa, Furukawa Hiroshi
Journal: Annals of Oncology (2014)
In Memory of Daniel — Reviving Research to Prevent Gun Violence
Authors: Chana A. Sacks
Journal: New England Journal of Medicine (2015)

At the moment that Daniel was shot, I had just fallen asleep after a night on call in the cardiac intensive care unit. My attending during that rotation was Robert Gerszten, who offered us insights from the burgeoning field of metabolomics and cardiovascular disease: that alterations in levels of blood metabolites may precede chronic illnesses by decades — knowledge that might someday enable us to identify people at risk for diseases years before the first clinical manifestation. Contemplating the possibilities of this concept, caring for critically sick patents, and studying the vast cardiology literature, I found my mind filled with . . .
Links between non-profit foundations and companies pose potential conflicts of interest
Authors: M. Limb
Journal: BMJ (2011)

Big philanthropic foundations are transforming public health around the world, but their links to food and drug companies pose potential conflicts of interest, says a study.

The research says that some of the corporations benefit directly from grants from foundations, and foundations in turn have investments in the corporations to which they award the grants.

Foundation board members and decision makers also sit on the boards of some for-profit corporations benefiting from their grants.

Three experts on public health examined the activities, financial investments, and institutional relations of five of …
TREATMENT OF VARIOLA BY BICHLORID BATHS.
Authors: H. A. INGALLS
Journal: JAMA (1900)

During March, April and May last, Dr. R. L. Yeager and myself treated thirty-six cases of variola, of which one was hemorrhagic and thirteen confluent, without mortality, by means of these baths. Our first case was seen in the papulo-vesicular stage, and we began the baths with the view of lessening the stage of pustulation, thereby securing a minimum of pitting, believing that pustulation was due to the ordinary pus cocci in the pores of the skin, and that in those vesicles that did suppurate the destructive process would be limited to the superficial layer. This case was a confluent one and we were pleased to note that not only was the disease lessened in pustulation and pitting, but that the patient was fairly comfortable, no opium being needed, and there was but little distortion of features at the beginning of the stage of pustulation and but a trace of
Physicians and Human Rights
Authors: Quentin D. Young
Journal: JAMA (1990)

Sudan, which is the largest country in Africa, is now ruled by a military government intent on establishing an Islamic state. Hundreds of Sudanese citizens have been jailed and, in some cases, tortured since June 1989, when a relatively unknown military officer, Lieutenant General Omer al-Bashir, seized power from the elected government of Sadiq el Mahdi. Blaming the multiparty system for a stagnant economy and corruption, General al-Bashir immediately abolished all unions and political parties; banned professional associations of lawyers, engineers, and physicians; and created a new security agency called the Security of the Revolution, which, according to former detainees, is staffed by Islamic fundamentalists and is responsible for many of the arrests and much of the torture. 1   Much of the repression, especially in the capital of Khartoum, has been directed against those groups—mainly politicians, physicians, and academics—that the government fears as potentially capable of organizing a political challenge
Low-Dose Etoposide Enhances Telomerase-Dependent Adenovirus-Mediated Cytosine Deaminase Gene Therapy through Augmentation of Adenoviral Infection and Transgene Expression in a Syngeneic Bladder Tumor Model
Authors: Gia-Shing Shieh, Ai-Li Shiau, Yi-Te Yo, Pey-Ru Lin, Chao-Ching Chang, Tzong-Shin Tzai, Chao-Liang Wu
Journal: Cancer Research (2006)

Abstract The human telomerase reverse transcriptase (hTERT) promoter can selectively drive transgene expression in many telomerase-positive human cancer cells. Here we evaluated combination therapy of adenoviral vector Ad-hTERT-CD encoding E. coli cytosine deaminase (CD) driven by the hTERT promoter and low-dose etoposide (0.1 μg/mL) for treating bladder cancer. Ad-hTERT-CD conferred sensitivity to 5-fluorocytosine (5-FC) in bladder cancer cells, which could be enhanced by etoposide treatment, but not in normal cells. Such effect was correlated with up-regulation of hypoxia-inducible factor (HIF)-1α expression. By contrast, etoposide activated p53 and down-regulated hTERT promoter activity in normal cells. Etoposide also increased adenoviral infection via enhancement of coxsackie-adenovirus receptor expression on bladder cancer and normal cells. Combination index analysis revealed that combined therapy of Ad-hTERT-CD (109 plaque-forming units)/5-FC (200 mg/kg) with etoposide (2 mg/kg) synergistically suppressed tumor growth and prolonged survival in mice bearing syngeneic MBT-2 bladder tumors. This combination therapy regimen induced complete tumor regression and generated antitumor immunity in 75% of tumor-bearing mice. Furthermore, increased infiltrating CD4+ and CD8+ T cells and necrosis within tumors were found in mice receiving combination therapy of Ad-hTERT-CD and etoposide compared with those treated with either treatment alone. Thus, the potential high therapeutic index of the combination therapy may be an appealing therapeutic intervention for bladder cancer. Furthermore, because a majority of human tumors exhibit high telomerase activity, adenovirus-mediated CD gene therapy driven by the hTERT promoter in combination with low-dose etoposide may be applicable to a broad spectrum of cancers. (Cancer Res 2006; 66(20): 9957-66)
Response to isoproterenol as a prognostic indicator of evolution from hypertrophic cardiomyopathy to a phase resembling dilated cardiomyopathy
Authors: Satoru Kawano, Keiji Iida, Katsuji Fujieda, Kimihiko Yukisada, El Sersi Magdi, Yuko Iwasaki, Fumiko Tabei, Iwao Yamaguchi, Yasuro Sugishita
Journal: Journal of the American College of Cardiology (1995)
USE OF RECONSTRUCTIVE SURGERY IN CERTAIN TYPES OF DEFORMITIES OF THE FACE
Authors: GORDON B. NEW
Journal: JAMA (1934)

A large number of deformities, for correction of which reconstructive surgery is required, are seen primarily by laryngologists. Consequently, we are considering some applications of the principles of this type of surgery for certain types of deformities of the face that are of especial interest to laryngologists. There are certain general principles in reconstructive surgery that are the same whether applied to this field or to others. Some of these principles are applied in the making of a tubed flap, a delayed flap, a fullthickness skin graft or a Thiersch graft, or in the grafting of bone or cartilage. However, in operations about the face certain problems require additional consideration, owing to local anatomic, functional and cosmetic requirements. No field of surgery requires more careful preoperative study, exacting surgical technic, care in handling tissues, and close postoperative observation. Of the many deformities that occur about the face, we have selected
Assessment of the propensity for covalent binding of electrophiles to biological substrates.
Authors: R M Carlson
Journal: Environmental Health Perspectives (1990)

Electrophilic character is associated with the ability of external agents to interact with centers of electron density in biological macromolecules and to cause the interruption or alternation of normal activity. With the observation of site specificity in mutagenic events. Pearson's hard/soft acid-based (HSAB) theory is presented as a useful concept in correlating chemical observations in the absence of detailed direct knowledge of the process. Methods for the evaluation of carbon electrophiles (e.g., carbocation character) as reactants are reviewed as potential physical parameters that could be applied in developing quantitative structure-activity relationships.
APPEARANCE OF THE TONGUE IN B. COLI INFECTION
Authors: A. Pérez Miró
Journal: JAMA (1927)

To the Editor:  —After observing for many years the characters of the tongue inB. coliinfection, I think these notes may have some practical interest. The tongue exhibits a strawberry punctate appearance. The more confluent and close the points or dots, the more serious the infection. On the contrary, they become more scattered and discrete as the infection subsides. They remain, however, while the infection continues. Case reports are not needed to prove this observation: it is enough to test it in a patient. If a bacteriologic examination of the centrifugalized urine is made,B. coliwill be usually found. This phenomenon suggests per se the diagnosis, and if present in other conditions, one may be sure that there is also an associated colibacillary infection. In a Spanish textbook they speak of this tongue as typical of influenza. It is not so. When this kind of tongue is seen
Abscess of the Heart
Authors: ALFRED ZETTNER, VICTOR J. IRMIERE
Journal: Circulation (1959)

At autopsy we encountered a large abscess of the interatrial septum as a complication of acute vegetative and ulcerative endocarditis, which was probably bacterial. The abscess was connected by a fistula to the aorta and furthermore had ruptured into the left atrium. A search of the literature failed to disclose a similar lesion.
Protecting the Millimeter of Mercury
Authors: A. HOLLMAN
Journal: JAMA (1978)

<h3>To the Editor.—</h3> Since our foundation in 1975, we have been campaigning against the proposal that the Système International (SI) unit of measurement for pressure, the pascal (Pa) or kilopascal (kPa), should replace the millimeter of mercury (mm Hg) for clinical pressure measurements, such as the blood pressure and intraocular pressure. We have had some success in this. At first there was little governmental opposition to the European Economic Community's directive (71/354) that the kilopascal should replace the millimeter of mercury by 1977, but by alerting European physicians to this proposal, a stay of execution until Dec 31, 1979, has been achieved. However, there is now an urgent need for further action. The World Health Organization seems to take the view that the millimeter of mercury (and other column measurements of pressure) will be retained only "for the time being" and that the kilopascal and pascal will be the future