tbuckley/cabot-search huggingface dataset:
Physicians Need Better Line on How, When to Respond to Patients via Telephone
Authors: Jody W. Zylke
Journal: JAMA (1990)

FOR MANY patients, reaching out and touching their physicians by telephone is a convenience. For many physicians, telephone calls are at best a bother and at worst a liability.  But they are also a fact of life for many clinicians. It has been estimated that pediatricians, for example, spend 27% of practice time on the phone.  Some expertise in handling phone calls would therefore be useful, and it may become necessary as concern has been raised about potential medicolegal liability arising from advice given over the telephone.  Dealing with patients by telephone clearly is not the same as seeing them. Obviously, a physician cannot perform a physical examination or do laboratory tests.  Peter Curtis, MD, professor of family medicine at the University of North Carolina, Chapel Hill, points out a number of other differences. For example, there's a smaller number of problems that present than the general scattering of primary
Emergence of Oseltamivir-Resistant Pandemic H1N1 Virus during Prophylaxis
Authors: Mariana Baz, Yacine Abed, Jesse Papenburg, Xavier Bouhy, Marie-Ève Hamelin, Guy Boivin
Journal: New England Journal of Medicine (2009)

To the Editor: Neuraminidase inhibitors (oseltamivir and zanamivir) are recommended for treatment of severe illness caused by the 2009 pandemic influenza A (H1N1) virus, and their use has also been advocated for postexposure prophylaxis in high-risk persons.1 We report the emergence of an oseltamivir-resistant virus in a familial cluster of infections with the 2009 H1N1 virus. In a 13-year-old boy with asthma, infection with the 2009 H1N1 virus developed and was confirmed by reverse-transcriptase polymerase-chain-reaction (RT-PCR) testing of a nasopharyngeal aspirate. Administration of oseltamivir (60 mg twice a day for 5 days for this boy who weighed 32 kg) was . . .
Research in Medical Education
Authors: Charlene Breedlove
Journal: JAMA (1996)

In an increasingly complex health care environment, medical schools and teaching hospitals are merging and reconfiguring their organizational structures and facilities. Concomitant with these new organizational arrangements is a shift toward more community-based ambulatory care sites for providing clinical training. As the teaching and research-oriented culture of the academic medical center encounters the market-driven values of managed care organizations, how is the goal of providing an appropriate  of patient care being defined and taught across sites? How are various training sites and institutions monitoring their success in teaching quality patient care? And how are educators preparing physicians clinically, administratively, and ethically for a more challenging practice environment that emphasizes patient outcomes?  ForTHE Journal's1997 Medical Education issue, we would like to see articles reporting research on and analysis of how, in the face of service and contract demands oriented toward cost containment, medical training is strengthening physicians' professional
A Case of Metabolic Mimicry
Authors: Manfred L. Karnovsky
Journal: New England Journal of Medicine (1979)

Sometimes a drug or other exogenous substance affects cellular enzymatic processes in such a way as to mimic, more or less precisely, the results of a gene mutation. Only a few examples come to mind, of which the most striking, if rather complex, situation involves an apparently new genetic disease described in this issue of the Journal. Rather general mimicry is evident when one compares the biochemical patterns in that disease — a recurrent hypoglycemia associated with glutaric aciduria Type II — with the metabolic picture that results from ingestion of hypoglycin (L-2-amino-3-[methylenecyclopropyl]-propionic acid).1 More restricted mimicry may also . . .
Salicylate Ototoxicity
Authors: Eugene N. Myers, Joel M. Bernstein, George Fostiropolous
Journal: New England Journal of Medicine (1965)

IT is known that large doses of salicylates produce deafness, tinnitus and vertigo. These symptoms are often used to titrate the dosage of this medication necessary to relieve the pain of severe arthritis. Their reversibility makes such a program possible.The concept that these symptoms are dose related and reversible is not well documented in the literature of otology or rheumatology. There is, in fact, no report indicating the severity or nature of the hearing loss attributable to this drug. Moreover, blood salicylate levels have never been correlated with audiometric studies in acute salicylate intoxication.The present report represents a . . .
That "Remarkable Case."
Authors: W. L. Worcester
Journal: JAMA (1891)

<h3>To the Editor:</h3> —I cannot help thinking that there must be an element of deception in the very remarkable case reported by Dr. Galbraith in your last issue. Apart from the inherent improbability of the extremely high temperatures noted, it seems to me a physical impossibility, so long as the circulation of the blood is maintained, that the temperature in the axilla should be 20 degrees higher than in the mouth. A temperature of 171°, or even 151° F., can only be borne by the finger for a very brief time without severe pain, and I think it may be set down as certain, that with a temperature approaching even the lower of these points, the vapor of the breath would form a cloud, in a room at the ordinary temperature, as that of a healthy person does on a cold day. I would suggest, in case of opportunity for
Bowen's disease of the leg treated with weekly pulses of 5% fluorouracil cream
Authors: N Stone, S Burge
Journal: British Journal of Dermatology (1999)

Journal Article Bowen's disease of the leg treated with weekly pulses of 5% fluorouracil cream Get access N Stone, N Stone Department of Dermatology, Stoke Mandeville Hospital, Aylesbury, U.K., E mail: nataliestone@sbnhst.ftech.co.uk Search for other works by this author on: Oxford Academic Google Scholar S Burge S Burge Department of Dermatology, Stoke Mandeville Hospital, Aylesbury, U.K., E mail: nataliestone@sbnhst.ftech.co.uk Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 140, Issue 5, 1 May 1999, Pages 987–988, https://doi.org/10.1046/j.1365-2133.1999.02854.x Published: 01 May 1999
Orthopedic Surgery in Infancy and Childhood
Authors: Paul P. Griffin
Journal: JAMA (1964)

As the authors stated in the preface to the first edition, they have attempted to bring together into one volume the diseases and syndromes encountered in the practice of children's orthopedics. In the second edition, there are two new chapters, and material in some of the others has been given more thorough coverage. These additions have improved the effectiveness of the book. It is, of course, impossible to discuss in detail all aspects of the diseases and conditions of the neuromuscular skeletal system in children that the orthopedist encounters, but the authors have done an outstanding job in selecting important conditions to be discussed. The book is not a reference work because its scope is not that extensive, and the authors make no effort to discuss etiology, treatment, etc, from the several viewpoints that may exist. They present the orthopedic problems of children as they see and treat them in
Targeted Treatment of Active Trachoma—Reply
Authors: Deborah Dean, Berna Atik, Ton Thi Kim Thanh, Vu Quoc Luong, Stephan Lagree
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The abscopal effect of local radiotherapy is induced by TGFβ blockade
Authors: Julie Diamond, Claire Vanpouille-Box, Mary Helen Barcellos-Hoff, Silvia C Formenti, Sandra Demaria
Journal: Journal for ImmunoTherapy of Cancer (2013)

Meeting abstracts Radiotherapy (RT) is employed to achieve local cancer control. However, in rare patients, regression of metastases outside of the radiation field has been reported after irradiation of one tumor site, a phenomenon known as abscopal effect. We have previously shown in experimental
Matrix elasticity, replicative senescence and DNA methylation patterns of mesenchymal stem cells
Authors: Anne Schellenberg, Sylvia Joussen, Kristin Moser, Nico Hampe, Nils Hersch, Hatim Hemeda, Jan Schnitker, Bernd Denecke, Qiong Lin, Norbert Pallua, Martin Zenke, Rudolf Merkel, Bernd Hoffmann, Wolfgang Wagner
Journal: Biomaterials (2014)
1,25-Dihydroxyvitamin D stimulation test for osteoblast function in normal and osteoporotic postmenopausal women.
Authors: R J Duda, R Kumar, K I Nelson, A R Zinsmeister, K G Mann, B L Riggs
Journal: Journal of Clinical Investigation (1987)

The cause of bone loss in postmenopausal osteoporosis--decreased bone formation or increased bone resorption--is controversial. Synthesis of bone--Gla protein (BGP), a specific osteoblast product, is stimulated by 1,25-dihydroxyvitamin D3 [1,25(OH)2D] in vitro. Thus, increases in serum BGP levels during 1,25(OH)2D administration might provide a useful dynamic index of osteoblast function. We compared 14 postmenopausal osteoporotic women with 12 age-matched postmenopausal normal women before and during 6 d of 1,25(OH)2D administration (2.0 micrograms/d). Serum BGP levels were similar at baseline and increased during treatment in both groups (P less than 0.001). However, trend analysis showed a greater (P less than 0.01) increase in the osteoporotic women. These data do not support the hypothesis that defective osteoblast function is the major cause of bone loss in postmenopausal osteoporosis.
Fractal Clustering of Ventricular Ectopy Correlates With Sympathetic Tone Preceding Ectopic Beats
Authors: Kenneth M. Stein, Labros A. Karagounis, Jeffrey L. Anderson, Paul Kligfield, Bruce B. Lerman
Journal: Circulation (1995)

Background Fractal geometric analysis of ventricular ectopy yields a fractal dimension, which can range from zero to one and is inversely related to clustering of ventricular premature contractions (VPCs). Low values of this fractal dimension, which reflect significantly nonuniform distributions of ventricular ectopy, are found in patients with life-threatening ventricular arrhythmias and predict adverse outcomes in selected patients with congestive heart failure and with mitral regurgitation. However, the physiological mechanism and correlates of the fractal dimension are unknown. Methods and Results To explore the physiological correlates of clustered ventricular ectopy, we studied 30 patients with a history of sustained ventricular tachycardia or ventricular fibrillation who had inducible sustained monomorphic ventricular tachycardia during electrophysiological study and also underwent drug-free 24-hour ambulatory ECG. In addition to fractal dimension (determined by use of our previously described algorithm), we measured the mean RR interval (±SD) for all sinus beats preceding a sinus beat and for all sinus beats preceding a single VPC and the mean root-mean-square difference (RMSSD) of all windows of 15 successive RR intervals (excluding ectopic beats) preceding a sinus beat and preceding a single VPC. Based on the directional changes of mean RR (a measure of both sympathetic and parasympathetic tone) and of RMSSD (a measure of parasympathetic tone), each patient’s inferred relative sympathetic tone preceding ventricular ectopy was classified as increased, unchanged, or decreased. If these values changed concordantly, relative sympathetic tone was indeterminate. Fractal dimension did not correlate with the mean RR interval, SD of the RR interval, or RMSSD preceding sinus beats or preceding VPCs (all P &gt;.10). In 20 patients, fractal dimension was significantly lower among those with increased relative sympathetic tone (n=14) than those with unchanged or decreased sympathetic tone (n=6, P =.008). Ten patients had indeterminate relative sympathetic tone. Conclusions Clustering of ventricular ectopy, as measured by the fractal dimension, is observed in patients at increased risk of sudden cardiac death. A low fractal dimension (clustered ventricular ectopy) is related to changes in heart rate and heart rate variability that are consistent with transient increases in cardiac sympathetic tone.
Suppression of Malaria (P. Berghei) by Milk
Authors: B. G. Maegraith, T. Deegan, E. S. Jones
Journal: BMJ (1952)

grossly reduced because of the deficiency in the blood of a factor called the Christmas factor.The Christmas factor can be obtained most readily from serum, and in some features resembles the serum factor VII of Koller et al. (1951).It differs greatly from the antihaemophilic globulin, and the blood from patients with true haemophilia (antihaemophilic globulin deficiency) is as effective as is normal blood in correcting the clotting abnormality in the blood or plasma of patients with Christmas disease.In the treatment of haemorrhage in cases of Christmas disease concentrated preparations of antihaemo- philic globulin are ineffective.
Systemic lupus erythematosus presenting as a recurrent sore throat and oral ulceration: a case report
Authors: SHEILA M. O'NEILL, JOHN THOMSON, ALEXANDRA M.M. STRONG, WILLIAM LANG
Journal: British Journal of Dermatology (1977)

Journal Article Systemic lupus erythematosus presenting as a recurrent sore throat and oral ulceration: a case report Get access SHEILA M. O'NEILL, SHEILA M. O'NEILL Department of Dermatology, Glasgow Royal Infirmary, Glasgow Search for other works by this author on: Oxford Academic Google Scholar JOHN THOMSON, JOHN THOMSON Department of Dermatology, Glasgow Royal Infirmary, Glasgow Search for other works by this author on: Oxford Academic Google Scholar ALEXANDRA M.M. STRONG, ALEXANDRA M.M. STRONG Department of Dermatology, Glasgow Royal Infirmary, Glasgow Search for other works by this author on: Oxford Academic Google Scholar WILLIAM LANG WILLIAM LANG Department of Otolaryngology, Glasgow Royal Infirmary, Glasgow Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 96, Issue 2, 1 February 1977, Pages 211–213, https://doi.org/10.1111/j.1365-2133.1977.tb12546.x Published: 01 February 1977
Not going on a journey: histamine toxicity
Authors: P. Wilmshurst, M. Hallworth
Journal: BMJ (2014)

According to folklore, itchy feet prophesy travel and itchy palms predict that a person will get money. But are they actually symptoms of histamine toxicity?

At a recent departmental meal, one of us (PW) noticed a peppery taste while eating tuna. During dessert, the soles of his feet became intensely itchy. A few minutes later he developed a forceful heartbeat and a pounding headache so he left the restaurant early. Ten minutes later he became lightheaded, followed by marked vasodilatation of the head, chest, and feet. He took chlorpheniramine and the vasodilatation later …
Renal failure in otherwise uncomplicated acute viral hepatitis.
Authors: S P Wilkinson, M H Davies, B Portmann, R Williams
Journal: BMJ (1978)

Twelve patients with otherwise uncomplicated acute viral hepatitis (two were HBsAg-positive) developed renal failure. Apart from dehydration due to repeated vomiting in one patient, no factor responsible for precipitating renal failure could be identified. The clinical course was characterised by renal failure with plasma urea concentrations reaching maximum values of 26-69 mmol/l (175-416 mg/100 ml). Ten patients needed dialysis for up to two weeks. Seven patients recovered completely, while the other five died from sepsis. The types of renal failure were similar to those described in fulminant hepatic failure and cirrhosis--namely, functional renal failure in five patients and acute tubular necrosis in seven. Two of the patients with functional renal failure later developed tubular necrosis. The mechanism responsible for renal failure in acute viral hepatitis is uncertain, though endotoxaemia may contribute.
Crizotinib — Latest Champion in the Cancer Wars?
Authors: Bengt Hallberg, Ruth H. Palmer
Journal: New England Journal of Medicine (2010)

Three articles in this issue of the Journal report on the therapeutic potential of a new kid on the kinase inhibitor block: crizotinib, an ATP-competitive inhibitor of the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase.Kwak et al.1 summarize a study involving patients with non–small-cell lung cancer who were enrolled in a phase 1 trial, starting in 2008, hot on the heels of a study in which cell lines derived from non–small-cell lung tumors were shown to be sensitive to NVP-TAE6842 and crizotinib (PF-02341066).3,4 From a cohort of 1500 patients with non–small-cell lung cancer, 82 (5.5%) were found to . . .
UREMIA, ALKALOSIS, TETANY AND CARDIAC FAILURE
Authors: Wilfred S. Dennis
Journal: JAMA (1925)

To the Editor:  —The interesting case reported by Harrison and Perlzweig (The Journal, February 28, p. 671) has many points of resemblance to a case I have seen, in which, in addition to the uremia, there was alkalosis independent of the administration of alkali, and tetany. It was thought that the tetany had been induced because of the loss of chlorids, incident to persistent vomiting for a period of about thirty hours, and the development of an alkalosis; at any rate, replacing some of the chlorids by means of subpectoral injections of saline solution almost immediately relieved this distressing condition. Unfortunately, no check was made after this of the alkalosis, as the case terminated fatally during the next twenty-four hours. Necropsy was not obtained.  A man, aged 67, seen, February 7, in his room in a hotel, apparently had been in good health, and two nights preceding had gone out
Eligibility for Cholesterol Referral in Community-dwelling Older Adults
Authors: Teri A. Manolio, Curt D. Furberg, Patricia W. Wahl, Russell P. Tracy, Nemat O. Borhani, Julius M. Gardin, Linda P. Fried, Daniel H. O'Leary, Lewis H. Kuller
Journal: Annals of Internal Medicine (1992)

▪ Objectives: To assess the proportion of community-dwelling adults aged 65 years or older who are eligible for referral for lipoprotein analysis and intervention according to the National Cholesterol Education Program (NCEP) guidelines. ▪ Design: Cross-sectional study based on examinations and questionnaires collected in 1989 and 1990. ▪ Setting: Four communities in the U.S. in the Cardiovascular Health Study (CHS), a study of risk factors for heart disease and stroke in older adults. ▪ Participants: A sample of 4810 men and women ages 65 to 100 randomly selected and recruited from Health Care Financing Administration Medicare eligibility lists for the four communities; not institutionalized, not wheelchair-bound, not currently receiving therapy for cancer, not currently taking lipid-lowering medications, and not having eaten in the preceding 9 hours. ▪ Measurements: Total cholesterol and lipoprotein analysis measured in all participants. ▪ Results: Total cholesterol levels were less than 5.17 mmol/L (200 mg/dL) in 37% of participants, 5.17 to 6.19 mmol/L (200 to 239 mg/dL) in 39%, and 6.20 mmol/L (240 mg/dL) or greater in 24%. Compared with their counterparts, older participants, especially those over 80 years of age, were more likely to have levels below 5.17 mmol/L, as were men, nonwhites, and those with coronary heart disease or two or more coronary heart disease risk factors (P < 0.008 for all values). Based on this screening measurement, 2174 participants were eligible for lipoprotein analysis, 80% were eligible for dietary or drug therapy using NCEP guidelines. Overall, 46% of CHS participants were eligible for lipoprotein analysis and 36% for intervention by NCEP guidelines, based on a single cholesterol measurement. ▪ Conclusion: A substantial proportion of older adults in this community sample were eligible for lipoprotein analysis and intervention. Prospective studies of elderly persons are needed to determine the risk for incident coronary heart disease according to NCEP classifications and the benefits of lipid-lowering treatments in persons in this age group so that intervention strategies may best be targeted to an appropriately high-risk group.
Reply to Riccioni et al.
Authors: P. Akerman, D. Cantero
Journal: Endoscopy (2009)

We thank Dr. Riccioni et al. for their letter regarding their experience with spiral enteroscopy and comparing this with our results previously published in this journal [1]. Spiral enteroscopy is a new technique for deep small-bowel visualization [2]. The technique is unique in endoscopy because it converts rotational forces into linear advancement through the small bowel. When the spiral is rotated in the mobile small bowel, the small bowel is pleated on the overtube and enteroscope. For the experienced endoscopist familiar with enteroscopy and overtubes, learning to use the spiral technology is the major hurdle to mastering spiral enteroscopy.
Women and Health, United States 1980
Authors: Ruth Purtilo
Journal: JAMA (1981)

<i>Women and Health, United States</i>1980, is the most comprehensive and informative document on the health status of American women available today. In addition to being an invaluable and concise source for investigations in the health fields and social services, it is packed with information that affects the lives of millions of Americans. The document provides a profile of the progress that has been made but points to health care issues that pose ongoing problems as well. The stated purposes of the report are to (1) identify a broad range of health issues that are either unique to women or of special importance to them and (2) note the roles that women play both as providers and consumers of health care. The first of eight chapters provides an overview, highlighting the demographic context in which the data of the rest of the report are set and providing a general look