Humoral Hypercalcemia of Malignancy
Authors: WILLIAM J. BURTIS
Journal: Annals of Internal Medicine (1988)

Editorials1 March 1988Humoral Hypercalcemia of MalignancyWILLIAM J. BURTIS, M.D., Ph.D., TERENCE L. WU, B.S., KARL L. INSOGNA, M.D., ANDREW F. STEWART, M.D.WILLIAM J. BURTIS, M.D., Ph.D.Search for more papers by this author, TERENCE L. WU, B.S.Search for more papers by this author, KARL L. INSOGNA, M.D.Search for more papers by this author, ANDREW F. STEWART, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-108-3-454 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAt the Annual Meeting of the American Society for Bone and Mineral Research last June, three groups announced the isolation and amino-acid sequencing of a protein that appears to be responsible for humoral hypercalcemia of malignancy (HHM) (1-4). Isolation of the protein, the cloning of the cDNA that encodes it and the resultant elucidation of the full-length amino-acid sequence of the HHM-factor (5, 6) cap years of steady progress in this field and have implications that extend beyond the syndrome of humoral hypercalcemia of malignancy. It is timely to review the clinical syndrome as well as its history and pathophysiology,...References1. STREWLERSTERNJACOBS GPJ. Parathyroid hormone-like protein from human renal carcinoma cells: structural and functional homology with parathyroid hormone. J Clin Invest. 1987;In press. CrossrefMedlineGoogle Scholar2. MOSELEYKUBOTADIEFENBACH-JAGGER JMH. Parathyroid hormone-related protein purified from a human lung cancer line. Proc Natl Acad Sci USA. 1987;84:5048-52. CrossrefMedlineGoogle Scholar3. BURTISWUBUNCH WTC. Identification of a novel 17,000-dalton parathyroid hormone-like adenylate cyclase-stimulating protein from a tumor associated with humoral hypercalcemia of malignancy. 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In vitro adenylate cyclase-stimulating activity predicts the occurrence of humoral hypercalcemia of malignancy in nude mice. J Clin Invest. 1987;In press. MedlineGoogle Scholar22. STEWARTHOECKERSEGREMALLETTEAMATRUDAVIGNERY AJGLTA. Hypercalcemia in pheochromocytoma: evidence for a novel mechanism. Ann Intern Med. 1985;102:776-9. LinkGoogle Scholar23. MERENDINOINSOGNAMILSTONEBROADUSSTEWART JKLAA. A parathyroid hormone-like protein from cultured human keratinocytes. Science. 1986;231:388-90. CrossrefMedlineGoogle Scholar24. WUINSOGNAHOUGHMILSTONESTEWART TKLLA. Skin-derived fibroblasts respond to human PTH-like adenylate cyclase-stimulating proteins. J Clin Endocrinol Metab. 1987;65:105-9. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: The West Haven VA Medical Center West Haven Yale University School of Medicine New Haven, Connecticut PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByDisorders of Calcium and Phosphorus Metabolism and the Proteomics/Metabolomics-Based ResearchOxidation of 1,8-oxybis(ethyleneethoxyethylenethio)anthracene-9,10-dione into sulfoxide changes the selectivity: Synthesis, spectroscopy and X-ray crystallographyCalcium Homeostasis in Kidney DiseaseSynthetic biology-based cellular biomedical tattoo for detection of hypercalcemia associated with cancerOncologic Metabolic EmergenciesHypercalcemia in Inpatient Setting: Diagnostic Approach and ManagementOptical probes for the detection of protons, and alkali and alkaline earth metal cationsOncologic Metabolic EmergenciesNon-parathyroid HypercalcemiaPaciente con virus de la inmunodeficiencia humana, hipercalcemia y hormona paratiroidea normalInhibition of epidermal growth factor receptor signalling reduces hypercalcaemia induced by human lung squamous-cell carcinoma in athymic miceDiagnostic approach to hypercalcemia: relevance of parathyroid hormone and parathyroid hormone-related protein measurementsEstablishment of two human small cell lung cancer cell lines: the evidence of accelerated production of parathyroid hormone-related protein with tumor progressionEndokrine OrganeThe management of hypercalcemia of malignancyClodronate and Other Bisphosphonates as Supportive Therapy in Osteolysis Due to MalignancyHistomorphometric evidence for osteoclast-mediated bone resorption in metastatic breast cancerParaneoplastic Syndromes Associated With Lung CancerParaendocrine SyndromesParathyroid hormone-related protein, chromogranin A, and calcitonin gene products in the neuroendocrine skin carcinoma cell lines MKL1 and MKL2Co-purification of calcium transport-stimulating and DNA synthesis-stimulating agents with parathormone-like activity isolated from the hypercalcaemic strain of the Walker 256 tumourRationale for the use of bisphosphonates in bone metastases1,25-Dihydroxyvitamin D-related hypercalcemia in lymphoma: Two case reportsProduction and characterisation of monoclonal antibodies to parathyroid hormone-related proteinEffect of parathyroid hormone-like peptides on 25-hydroxyvitamin D-1 alpha-hydroxylase activity in rodentsParathyroid Hormone-Related ProteinMetastases in the Bone MarrowDisorders of Calcium and Magnesium MetabolismEtiologies and Therapy of HypercalcemiaUse of Clodronate and Calcitonin in Hypercalcemia Due to MalignancyHypercalcemiaHypercalcemia 1 March 1988Volume 108, Issue 3Page: 454-457KeywordsCloningComplementary DNAHypercalcemiaOsteocalcinProteinsVeteran care Issue Published: 1 March 1988 PDF DownloadLoading ...