tbuckley/cabot-search huggingface dataset:
Nifedipine and Oncologic Raynaud Phenomenon
Authors: Alexander Hantel, Eric K. Rowinsky, Ross C. Donehower
Journal: Annals of Internal Medicine (1988)

Letters and Corrections1 May 1988Nifedipine and Oncologic Raynaud PhenomenonALEXANDER HANTEL, M.D., ERIC K. ROWINSKY, M.D., ROSS C. DONEHOWER, M.D.ALEXANDER HANTEL, M.D.Search for more papers by this author, ERIC K. ROWINSKY, M.D.Search for more papers by this author, ROSS C. DONEHOWER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-108-5-767_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTO THE EDITOR: Oncologic Raynaud phenomenon develops in approximately 40% of men with testicular cancer who receive combination chemotherapy (1). The cause of the phenomenon in these patients is unclear but appears related in part to the effects of bleomycin on peripheral arteries (2). This complication can be disabling, particularly in young men, who are generally vigorous, and until recently, no consistently effective therapy was available. Nifedipine therapy is successful in preventing idiopathic Raynaud phenomenon, but is less effective in patients with underlying conditions such as systemic sclerosis, presumably due to the fixed nature of the vascular obstruction in the...References1. VOGELZANGBOSLJOHNSONKENNEDY HGKB. Raynaud's phenomenon: a common toxicity after combination chemotherapy for testicular cancer. Ann Intern Med. 1981;95:288-92. LinkGoogle Scholar2. BURKHARDTHOLTJEGEBBERS AWJ. Vascular lesions following perfusion with bleomycin. Virchows Arch [Path Anat]. 1976;372:227-36. CrossrefMedlineGoogle Scholar3. RODEHEFFERROMMERWIGLEYSMITH RJFC. Controlled double-blind trial of nifedipine in the treatment of Raynaud's phenomenon. N Engl J Med. 1983;308:880-3. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: The Johns Hopkins Oncology Center Baltimore MD 21205 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByTestis CancerVascular Toxicity of Antineoplastic AgentsComplications of surgery and chemotherapy for testicular cancerParaneoplastic Raynaud Phenomenon and Idiopathic Thrombocytopenic Purpura in Non–Small-Cell Lung CancerTesticular cancerThe clinical pharmacology and use of antimicrotubule agents in cancer chemotherapeuticsVascular toxicity and the mechanism underlying Raynaud's phenomenon in patients treated with cisplatin, vinblastine and bleomycin 1 May 1988Volume 108, Issue 5Page: 767-767KeywordsArteriesCombination chemotherapySclerodermaTesticular cancer Issue Published: 1 May 1988 PDF DownloadLoading ...
Clinical Characteristics and Overall Survival in Genitourinary Sarcomas Treated with Curative Intent: A Multicenter Study
Authors: N. Mondaini, D. Palli, C. Saieva, G. Nesi, A. Franchi, R. Ponchietti, S. Tripodi, C. Miracco, E. Meliani, M. Carini, L. Livi, I. Zanna, S. Trovarelli, V. Marino, G. Vignolini, G. Pomara, V. Orlando, G. Giubilei, C. Selli, M. Rizzo
Journal: European Urology (2004)
Differential effect of methotrexate on the increased CCR2 density on circulating CD4 T lymphocytes and monocytes in active chronic rheumatoid arthritis, with a down regulation only on monocytes in responders
Authors: T Ellingsen, N Hornung, B K Moller, J H Poulsen, K Stengaard-Pedersen
Journal: Annals of the Rheumatic Diseases (2006)

To evaluate the effect of orally administered methotrexate (MTX) on the density of CC chemokine receptor 2 (CCR2) and CXC chemokine receptor 3 (CXCR3) on circulating monocytes, and the coexpression of CXCR3 and CCR2 on CD4 T lymphocytes in patients with active chronic rheumatoid arthritis.
Clinical, Laboratory and Histological Associations in Adults with Nonalcoholic Fatty Liver Disease†
Authors: Brent A. Neuschwander-Tetri, Jeanne M. Clark, Nathan M. Bass, Mark L. Van Natta, Aynur Unalp-Arida, James Tonascia, Claudia O. Zein, Elizabeth M. Brunt, David E. Kleiner, Arthur J. McCullough, Arun J. Sanyal, Anna Mae Diehl, Joel E. Lavine, Naga Chalasani, Kris V. Kowdley
Journal: Hepatology (2010)

Abstract The Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) was formed to conduct multicenter studies on the etiology, contributing factors, natural history, and treatment of nonalcoholic steatohepatitis (NASH). The aim of this study was to determine the associations of readily available demographic, clinical, and laboratory variables with the diagnosis of NASH and its key histological features, and determine the ability of these variables to predict the severity of nonalcoholic fatty liver disease (NAFLD). A total of 1266 adults were enrolled in NASH CRN studies between October 2004 and February 2008, of whom 1101 had available liver histology. The median age was 50 years; 82% were white and 12% Hispanic. The median body mass index was 33 kg/m2; 49% had hypertension and 31% had type 2 diabetes. On liver biopsy, 57% were judged to have definite NASH and 31% bridging fibrosis or cirrhosis. Using data from the 698 patients with liver biopsies within 6 months of clinical data, patients with definite NASH were more likely to be female and have diabetes, higher levels of aspartate and alanine aminotransferases, alkaline phosphatase, gamma glutamyl transpeptidase, and homeostasis model assessment of insulin resistance (HOMA-IR). Progressive models for predicting histological diagnoses performed modestly for predicting steatohepatitis or ballooning (area under receiver operating characteristic curves [AUROC] ranged from 0.70-0.79), and better for advanced fibrosis (AUROC 0.73-0.85). Conclusion: Readily available clinical and laboratory variables can predict advanced fibrosis in adults with NAFLD, but additional information is needed to reliably predict the presence and severity of NASH. Prospective studies of this well-characterized population and associated tissue bank samples offer a unique opportunity to better understand the cause and natural history of NAFLD and develop more precise means for noninvasive diagnosis.
Growth hormone alone or combined with metoprolol preserves cardiac function after myocardial infarction in rats
Authors: Entela Bollano, Claes‐Håkan Bergh, Christer Kjellström, Elmir Omerovic, Vuk Kujacic, Kenneth Caidahl, Bengt‐Åke Bengtsson, Finn Waagstein, Jörgen Isgaard
Journal: European Journal of Heart Failure (2001)
Detection of Proliferative Breast Disease Four-Quadrant, Fine-Needle Aspiration
Authors: J. H. Ward, C. J. Marshall, G. B. Schumann, H. Hogle, L. A. Cannon-Albright, W. P. McWhorter, H. J. Eyre, M. H. Skolnick
Journal: JNCI Journal of the National Cancer Institute (1990)

Journal Article Detection of Proliferative Breast Disease Four-Quadrant, Fine-Needle Aspiration Get access John H. Ward, John H. Ward * Department of Medicine, University of Utah Medical CenterSalt Lake City, UT. *Correspondence to: John H. Ward, M.D., Department of Medicine, University of Utah Medical Center, Salt Lake City, UT 84132. Search for other works by this author on: Oxford Academic PubMed Google Scholar C. Jay Marshall, C. Jay Marshall Department of Pathology, University of Utah Medical CenterSalt Lake City, UT. Search for other works by this author on: Oxford Academic PubMed Google Scholar G. Berry Schumann, G. Berry Schumann Department of Pathology, University of Utah Medical CenterSalt Lake City, UT. Search for other works by this author on: Oxford Academic PubMed Google Scholar Hugh Hogle, Hugh Hogle Department of Surgery, University of Utah Medical CenterSalt Lake City, UT. Search for other works by this author on: Oxford Academic PubMed Google Scholar Lisa A. Cannon-Albright, Lisa A. Cannon-Albright Department of Medicine, University of Utah Medical CenterSalt Lake City, UT. Search for other works by this author on: Oxford Academic PubMed Google Scholar William P. McWhorter, William P. McWhorter Department of Medicine, University of Utah Medical CenterSalt Lake City, UT. Search for other works by this author on: Oxford Academic PubMed Google Scholar Harmon J. Eyre, Harmon J. Eyre Department of Medicine, University of Utah Medical CenterSalt Lake City, UT. Search for other works by this author on: Oxford Academic PubMed Google Scholar Mark H. Skolnick Mark H. Skolnick Department of Medical Informatics, University of Utah Medical CenterSalt Lake City, UT. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 82, Issue 11, 6 June 1990, Pages 964–966, https://doi.org/10.1093/jnci/82.11.964 Published: 06 June 1990 Article history Received: 02 January 1990 Revision received: 02 March 1990 Accepted: 15 March 1990 Published: 06 June 1990
Voluntary Medical Male Circumcision: Strategies for Meeting the Human Resource Needs of Scale-Up in Southern and Eastern Africa
Authors: Kelly Curran, Emmanuel Njeuhmeli, Andrew Mirelman, Kim Dickson, Tigistu Adamu, Peter Cherutich, Hally Mahler, Bennett Fimbo, Thembisile Khumalo Mavuso, Jennifer Albertini, Laura Fitzgerald, Naomi Bock, Jason Reed, Delivette Castor, David Stanton
Journal: PLoS Medicine (2011)

Voluntary medical male circumcision (VMMC) reduces female-to-male HIV transmission by approximately 60%; modeling suggests that scaling up VMMC to 80% of men 15- to 49-years-old within five years would avert over 3.3 million new HIV infections in 14 high priority countries/regions in southern and eastern Africa by 2025 and would require 20.33 million circumcisions. However, the shortage of health professionals in these countries must be addressed to reach these proposed coverage levels. To identify human resource approaches that are being used to improve VMMC volume and efficiency, we looked at previous literature and conducted a program review. We identified surgical efficiencies, non-surgical efficiencies, task shifting, task sharing, temporary redeployment of public sector staff during VMMC campaign periods, expansion of the health workforce through recruitment of unemployed, recently retired, newly graduating, or on-leave health care workers, and the use of volunteer medical staff from other countries as approaches that address human resource constraints. Case studies from Kenya, Tanzania, and Swaziland illustrate several innovative responses to human resource challenges. Although the shortage of skilled personnel remains a major challenge to the rapid scale-up of VMMC in the 14 African priority countries/regions, health programs throughout the region may be able to replicate or adapt these approaches to scale up VMMC for public health impact.
Europe is lagging behind in fight against tuberculosis
Authors: Peter Moszynski
Journal: BMJ (2007)

The number of healthcare workers in sub-Saharan Africa will have to triple each year for 10 years if every person with HIV or AIDS is to get antiretroviral treatment, said researchers this week.Their study, published in AIDS Patient Care and STDs (2007;21:799-812), was one of seven-including one in this week's BMJ (2007;335:862-5)-selected for presentation at the launch at the US National Institutes of Health of the multi-journal global theme issue on poverty and human development.The BMJ was among 235 journals from 37 countries that took part in the global theme issue, coordinated by the Council of Science Editors.They published more than 750 articles between them, representing 110 countries (see bmj.com for a webcast and a link to a full list of citations on the council's website).More than five million people who need antiretroviral treatment don't receive it, said one of the authors of the AIDS Patient Care and STDs study, Salal Humair, of Lahore University, Pakistan.Limited human resources to treat HIV and AIDS is one of the main constraints to achieving universal coverage, he said.He and his coauthors, Till Bärnighausen, of the University of KwaZulu-Natal, and David Bloom, of the Harvard School of Public Health, estimate that antiretroviral treatment programmes in low and middle income countries currently lack 5000 to 10 000 doctors, 10 000 to 36 000 nurses, and 7000 to 21 000 pharmacists.However, the need for healthcare workers to administer treatment will increase as more and more people with HIV or AIDS survive.Even if no doctors emigrate, the authors estimate that sub-Saharan Africa alone will need 3000 extra doctors each year to treat people with HIV or AIDS.
Persistent sinus nodal electrograms during abnormally prolonged postpacing atrial pauses in sick sinus syndrome in humans: sinoatrial block vs overdrive suppression.
Authors: P Asseman, B Berzin, D Desry, D Vilarem, P Durand, C Delmotte, E H Sarkis, J Lekieffre, C Thery
Journal: Circulation (1983)

A transvenous electrode catheter technique was used for direct recording of bipolar sinus node electrograms during postpacing atrial pauses. Multiple repetitive local sinus node electrograms during atrial quiescence validate sinus node electrograms. Such atrial pauses with sinus node electrograms are due to sinoatrial block; atrial pauses without sinus node electrograms are due to overdrive suppression or improper recording. Eight consecutive patients were prospectively selected on the basis of a corrected sinus node recovery time greater than 1500 msec during diagnostic electrophysiologic evaluation. Six patients had atrial pauses with sinus node electrograms; three patterns of sinus node electrograms during atrial pauses were observed. We conclude that (1) sinus node electrogram recording is of value in understanding the mechanism underlying postpacing atrial pauses; (2) atrial pauses are usually (6/8) caused by sinoatrial block; (3) three patterns of sinus node electrograms are observed, thus making indirect interpretation unreliable.
Serum apolipoprotein profile of hypertriglyceridemic patients with chronic renal failure on hemodialysis: A comparison with type IV hyperlipoproteinemic patients
Authors: Maurizio R. Averna, Carlo M. Barbagallo, Antonio Galione, Antonio Carroccio, Mirella Labisi, Giuseppina Marino, Giuseppe Montalto, Alberto Notarbartolo
Journal: Metabolism (1989)
Immunological Studies of the Human Placenta CHARACTERIZATION OF IMMUNOGLOBULINS ON TROPHOBLASTIC BASEMENT MEMBRANES
Authors: W. Page Faulk, M. Jeannet, W. D. Creighton, A. Carbonara
Journal: Journal of Clinical Investigation (1974)

Immunohistological and elution studies of the human placenta revealed the presence of IgG on the trophoblastic basement membrane (TBM) which demonstrated specificity for placental but not lung, thyroid, or kidney basement membranes, suggesting the presence of a placenta-specific antigen in TBM. IgG comprised the bulk of immunoglobulin in eluates, and small amounts of IgA, trace amounts of IgM, but no IgE or IgD were identified in eluates. The distribution of IgG subclasses in eluate was not unusual as compared to maternal and neonatal sera, and Gm and Inv typing of eluates indicated that it was of maternal origin. Small amounts of eluate-IgG effectively inhibited the blastogenic response of unrelated lymphocytes to old tuberculin, phytohemagglutinin, and in one- or two-way mixed lymphocyte culture reactions. The inhibition was distinct from nonspecific inhibitors, and dose-response analysis indicated that eluate was very much more potent as an inhibitor than were the nonspecific inhibitors. Inhibition was shown to not be due to anti-HL-A activity, and was probably not due to aggregated IgG or immune complexes. Binding of eluate to lymphocytes was very loose as shown by washing experiments, and no binding could be shown by immunofluorescence. The capacity of eluate IgG to inhibit MLC was retained after pepsin digestion to F(ab')(2), suggesting that the inhibition reactions were immunological. It is suggested that eluate-IgG is maternal blocking antibody to a hitherto uncharacterized trophoblast antigen, and it is speculated that either abnormal antigen or aberrant responses to antigen could result in fetal wastage.
Long‐Term Changes in Inhalant Allergy in Asthmatic Children
Authors: B. Kjellman, G. Dalén
Journal: Allergy (1986)

In a representative cohort of 55 asthmatic schoolchildren the progress of the allergy per se was followed up prospectively for 8 years. Judged by clinical data, skin prick tests and RAST, a large majority of the children retained their allergies to pollen and animal danders. These allergens were predominant, whereas allergy to mites and moulds was less frequent. Serum IgE levels showed a strong tendency to remain high. Positive RAST and skin prick tests were also found in a substantial number of children with normal serum IgE concentrations.
Germany considers relaxing strict embryo research laws
Authors: J. Burgermeister
Journal: BMJ (2003)

Germany is in the middle of a national debate on embryo research after a speech by the minister of justice, Brigitte Zypries, in which she signalled that the government is preparing to relax the country's strict laws on embryo research.

German law currently forbids work on embryonic stem cells, with the exception of research on imported embryos left over from in vitro fertilisation that were created before 1 January 2002.

In a speech at Berlin's Humboldt University on 29 October, Brigitte Zypries said that there was an ethical obligation to push forward research on …
Allergen-induced late asthmatic reactions are associated with elevation of exhaled nitric oxide.
Authors: S A Kharitonov, B J O'Connor, D J Evans, P J Barnes
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

The concentration of nitric oxide (NO) is increased in the exhaled air of asthmatic patients and may reflect cytokine-mediated inflammation in the airways. We investigated whether allergen-induced inflammation causes an elevation in the level of exhaled NO. Of 25 patients who underwent allergen challenge, 16 developed dual early and late responses, whereas eight had a single early response. In the patients with a dual response, the maximal fall in FEV1 during the late response was 26.8 +/- 4.2% at 9 h and there was a significant increase in the level of exhaled NO (maximal increase of 59.4 +/- 9.8%) 10 h after challenge. There was a significant relationship between the size of the late response and the increase in exhaled NO (r = 0.75, p < 0.01). In patients who have a single early response, there was no significant increase in exhaled NO, with the exception of a single time point at 21 h. In five patients given a control challenge with methacholine there was no change in exhaled NO. There was no increase in exhaled NO after inhaled histamine in any of the patient groups. We conclude that the late asthmatic response to allergen is associated with elevated exhaled NO concentrations and that this provides further evidence that exhaled NO may reflect allergic inflammation in asthmatic airways, and may be a useful marker in monitoring asthma and its response to anti-inflammatory treatments. Whether endogenously produced NO plays a pathophysiologic role in the late response remains to be determined.
The incidence of invasive fungal infections in neutropenic patients with acute leukemia and myelodysplastic syndromes receiving primary antifungal prophylaxis with voriconazole
Authors: Jason N. Barreto, Cassidy L. Beach, Robert C. Wolf, Julianna A. Merten, Pritish K. Tosh, John W. Wilson, William J. Hogan, Mark R. Litzow
Journal: American Journal of Hematology (2013)

The objective of this study is to characterize the outcomes of primary antifungal prophylaxis with voriconazole in patients receiving intensive chemotherapy for acute myelogenous leukemia (AML) or myelodysplastic syndromes (MDS). We conducted a single center, retrospective, cohort study of consecutive adult patients with AML or MDS at Mayo Clinic between January 1, 2006 and July 1, 2010. The study included patients undergoing induction or first relapse combination chemotherapy who received voriconazole 200 mg orally twice daily as prophylaxis during the neutropenic phase. Patient records were evaluated until 30 days after neutrophil recovery for development of invasive fungal infection (IFI) as defined per EORTC/MSG 2008 criteria with computed tomography scans independently reviewed by a radiologist. Therapeutic drug monitoring and reasons for voriconazole discontinuation were documented. Twenty four episodes of IFI were detected among 165 consecutive patients for an overall incidence of 145 per 1000 patients. The incidence of IFI was 24, 42, and 78 per 1000 patients for proven, probable, and possible infection, respectively. Four patients developed proven IFI (n = 2 Aspergillus spp., n = 2 Rhizopus spp.). Serum voriconazole trough concentrations were available in 39 patients, and no statistically significant difference in voriconazole trough level was observed between those with versus without an IFI. Voriconazole prophylaxis was discontinued in 81 patients due to suspected IFI (n = 24), fever of unknown origin (n = 19), adverse events (n = 23), and other causes (n = 17). Voriconazole as primary IFI prophylaxis is safe and may be beneficial in AML/MDS patients receiving intensive chemotherapy.
Book Review Eugenic Nation: Faults and Frontiers of Better Breeding in Modern America (American Crossroads. 17.) By Alexandra Minna Stern. 347 pp., illustrated. Berkeley, University of California Press, 2005. $60 (cloth); $24.95 (paper). 0-520-24443-5 (cloth); 0-520-24444-3 (paper).
Authors: George Cunningham
Journal: New England Journal of Medicine (2006)
Imaging Systemic Inflammatory Networks in Ischemic Heart Disease
Authors: Matthias Nahrendorf, Stefan Frantz, Filip K. Swirski, Willem J.M. Mulder, Gwendalyn Randolph, Georg Ertl, Vasilis Ntziachristos, Jan J. Piek, Erik S. Stroes, Markus Schwaiger, Douglas L. Mann, Zahi A. Fayad
Journal: Journal of the American College of Cardiology (2015)
Measurement of Arterioles in Coarctation of the Aorta
Authors: ROBERT C. PAINTER, EDGAR A. HINES, JESSE E. EDWARDS
Journal: Circulation (1952)

In cases of aortic coarctation determinations of the wall-to-lumen ratio were made for the arterioles of the thyroid, pancreas, kidney and periadrenal tissue and compared with those for arterioles from the same organs in control cases. As in primary hypertension, there was, on the average, an increase in the wall-to-lumen ratio in each of the regions studied in the cases of coarctation as compared with the same tissues of the control group. This means that for arterioles of the same wall size the lumen was narrower in the cases of coarctation than in the control cases.
One in three NHS trusts face cash shortfall this financial year
Authors: Andrew Cole
Journal: BMJ (2005)

The increasingly market oriented nature of the NHS reform programme is placing a growing number of trusts at financial risk, warns a joint examination of NHS financial management by the public spending watchdogs, the National Audit Office and the Audit Commission.

The report says that almost a third of NHS bodies—189 individual organisations—face cash problems this financial year (2004-5). This is almost double the previous year's figure of 18%. The Department of Health confirmed that the NHS is heading for its first deficit, of £140m ($260m; £210m), for several years. At least …