Fatal Agranulocytosis Complicating Treatment with Ethacrynic Acid
Authors: J. GEOFFREY WALKER
Journal: Annals of Internal Medicine (1966)

Brief Communication1 June 1966Fatal Agranulocytosis Complicating Treatment with Ethacrynic AcidReport of a CaseJ. GEOFFREY WALKER, M.B.J. GEOFFREY WALKER, M.B.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-6-1303 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptClinical and animal trials with the new diuretic ethacrynic acid (2,3-dichloro-4(2 methylene butyryl) phenoxyacetic acid) suggest that it is exceptionally potent and in some cases far superior to either the organomercurials or the benzothiadiazines (1-13). A unique mode of action on the renal tubule has been suggested (10, 14-16). Because of the drug's potency, excessive loss of water and electrolytes with the development of hypochloremic alkalosis may occur (4, 5, 7, 8, 10, 12, 13). The only true side effects so far described, however, have been occasional gastrointestinal upsets (8, 10, 11) and hyperuricemia (7, 10), and no instance of...References1. BAERRUSSOMICHAELSONBEYER JEHFJKKH: A new class of diuretic-saluretic agents, the αβ-unsaturated ketone derivatives of aryloxyacetic acids. Pharmacologist 4: 158, 1962. Google Scholar2. SCHULTZCRAGOEBICKINGBULHOFERSPRAGUE EMEJJBWAJM: αβ-unsaturated ketone derivatives of aryloxyacetic acids, a new class of diuretics. J. Med. Pharm. Chem. 5: 660, 1962. CrossrefGoogle Scholar3. BAERMICHAELSONRUSSOBEYER JEJKHFKH: 2,3-dichloro-4- (2-methylenebutyryl)-phenoxyacetic acid (I), a novel and potent diuretic-saluretic agent. Fed. Proc. (abstract) 22: 598, 1963. Google Scholar4. CANNONAMESLARAGH PJRPJH: Methylenebutyryl phenoxyacetic acid: novel and potent natriuretic and diuretic agent. JAMA 185: 854, 1963. CrossrefMedlineGoogle Scholar5. DALEYEVANS DB: Diuretic action of ethacrynic acid in congestive heart failure. Brit. Med. 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PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByEtacrynic acidDIURETICSEtacrynic acidChemical Agents Which Suppress Myelopoiesis: Agranulocytosis and LeukemiaDiuretic DrugsLeukopenien und AgranulocytosenEffects of Ethacrynic Acid on Human Red Blood CellsDisorders of Leukocytes Leading to Recurrent InfectionEthacrynic acid and furosemideManagement of refractory heart failureUntersuchungen �ber die Wirksamkeit von Ethacryns�ure, Amiloride-HCl und Aldadiene-K bei NiereninsuffizienzEthacrynic acid: Its usefulness and untoward effectsClinical pharmacology furosemide and ethacrynic acidClinical selection of diuretic drugs in the management of cardiac edema∗THE COMPLICATIONS OF DIURETIC THERAPY IN PATIENTS WITH CIRRHOSIS 1 June 1966Volume 64, Issue 6Page: 1303-1305KeywordsBlood groupsCirrhosisClinical trialsDiureticsDrugsHematology and oncologyHospital medicinePlateletsResearch laboratoriesSalts Issue Published: 1 June 1966 PDF DownloadLoading ...