tbuckley/cabot-search huggingface dataset:
RUPTURE OF SAC AND DEATH OF FETUS IN ABDOMINAL PREGNANCY AT FULL TERM. IMMEDIATE OPERATION WITH RECOVERY.
Authors: J. B. EAGLESON
Journal: JAMA (1896)

The following case of abdominal pregnancy is reported as it presents some points of interest which are different from the few cases of this kind previously recorded. Mrs. B. is 36 years of age, and American born from German parentage. She is of slender build and rather under medium height. She was married at 18 and has a daughter aged 17. At the birth of the daughter both cervix and perineum were severely lacerated, causing her considerable trouble until they were operated on some five years later. After the repair of the laceration she enjoyed excellent health, with regular menstruation, until the beginning of this pregnancy. She menstruated last on March 21, 1894, but as the flow at that time was of short duration and very scanty, it is very probable that the pregnancy really began one month earlier. With the exception of the morning sickness her health continued quite
Predictors of preterm birth in patients with mild systemic lupus erythematosus
Authors: Megan E B Clowse, Daniel J Wallace, Michael Weisman, Andra James, Lisa G Criscione-Schreiber, David S Pisetsky
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Objective</h3> While increased disease activity is the best predictor of preterm birth in women with systemic lupus erythematosus (SLE), even women with low disease activity are at increased risk of this complication. Biomarkers that would identify at-risk pregnancies could allow interventions to prevent preterm birth. <h3>Method</h3> Measures of SLE activity, inflammation, placental health and renal function between 20 and 28 weeks gestation (mid-gestation) were correlated to preterm birth and gestational age at delivery in a prospective cohort of pregnant women with SLE. <h3>Result</h3> Of the 40 pregnancies in 39 women, all with mild–moderate SLE disease, 9 (23.7%) of the 38 live births were delivered preterm. Low C4 was the only marker of SLE activity associated with younger gestational age at delivery. Elevated ferritin and lower oestradiol correlated with younger gestational age at delivery. Renal function remained normal during all pregnancies at mid-gestation and did not correlate with preterm birth. Higher serum uric acid, however, correlated with younger gestational age at delivery. <h3>Conclusions</h3> In women with SLE with mild–moderate disease activity, ferritin, oestradiol and uric acid levels at mid-gestation may predict preterm birth. These markers may prove to be clinically useful in identifying pregnancies at particularly high risk for adverse outcomes.
HER2 status in gastric cancers: a retrospective analysis from four Chinese representative clinical centers and assessment of its prognostic significance
Authors: W.Q. Sheng, D. Huang, J.M. Ying, N. Lu, H.M. Wu, Y.H. Liu, J.P. Liu, H. Bu, X.Y. Zhou, X. Du
Journal: Annals of Oncology (2013)
Increased glycosphingolipid excretion associated with proteinuria.
Authors: R R Townsend, R M Orth, C M Clawson, S C Li, Y T Li
Journal: Journal of Clinical Investigation (1978)

The urine of patients with proteinuria of various etiologies was examined to determine if proteinuria alone was associated with significant glycosphingolipiduria. In all cases of proteinuria examined, the level of glycosphingolipids in the urine was found to be markedly elevated. There was no evidence of a glycosphingolipid storage disorder in any case. It was concluded that significant glycosphingolipiduria may occur in proteinuria as well as in the glycosphingolipid storage disorders.
THE DIFFERENTIATION OF CHOREA AND THE DISORDERS SIMULATING IT.
Authors: AUGUSTUS A. ESHNER
Journal: JAMA (1900)

In some of its aspects true chorea, the chorea of Sydenham, presents the features of an acute infectious disease. Among the phenomena suggestive of such an etiologic relationship are the mode of invasion, the seasonal prevalence, the self-limitation, the endocardial and articular complications, theliability to recurrence, and the postmortem findings in some cases. Further, optic neuritis has occasionally been observed. The actual causation of chorea yet awaits final solution, but the belief is growing that the disease is dependent on irritative disturbance of the motor cells of the cerebral cortex, of either infectious or toxic origin. In the etiology, heredity, sometimes direct, at other times indirect, is a not unimportant factor. It is not uncommon to obtain a history of the disease in the parents or in other members of the family. Chorea occurs almost invariably in neurotic stock, so that, as with infectious diseases, the predisposition or the susceptibility,
A Clinical Trial of Benactyzine Hydrochloride ("Suavitil") as a Physical Relaxant
Authors: A. Coady, E. C. O. Jewesbury
Journal: BMJ (1956)

A new drug has recently been introduced into this country for use in states characterized by emotional and physical tension. This drug, benactyzine hydrochloride ( suavitil ), is the hydrochloride of 2-diethylaminoethyl benzilate. It is a member of the group of anticholin ergic substances, and experimental work in Denmark suggests that it produces a state of emotional and physical relaxation without drowsiness. For convenience its name in this paper is shortened to benactyzine.
Studies on Ventriculo-Atrial Conduction and the Reentry Phenomenon
Authors: ANTHONY N. DAMATO, SUN H. LAU, GUSTAVUS A. BOBB
Journal: Circulation (1970)

Ventriculo-atrial conduction and the reentry phenomenon was studied during right ventricular and bundle of His pacing in the intact dog heart. Bipolar electrogram recordings were obtained from the sinus node, Bachman's bundle, the right and left atria, the bundle of His, and the ventricle. Retrograde conduction resulted in a specific change in the sequence of atrial activation. The recording of both antegrade and retrograde His deflections provided a more accurate means of comparing A-V and V-A conduction times. In all experiments retrograde conduction time exceeded antegrade conduction time. The A-V nodal region was found to be the zone of retrograde conduction delay and block. Increasing the driving rate of the heart, vagal stimulation, and isoproterenol, affected V-A conduction similar to the way in which these maneuvers affect A-V conduction. Reentry (ventricular echoes) commonly occurred when right ventricular or bundle of His pacing resulted in the reverse Wenckebach phenomenon.
New Trends in Gallbladder Imaging
Authors: Joseph F. Simeone
Journal: JAMA (1981)

GALLBLADDER disease accounts for more than 500,000 operations annually in the United States and is the most common indication for abdominal surgery and the fourth most common cause of surgical hospitalization in adults.<sup>1</sup> For almost 60 years, since the introduction by Graham and Cole<sub>2</sub>of the oral cholecystogram (OCG) in 1924, it has remained the unchallenged method for investigation of gallbladder disease. Nevertheless, despite its accuracy, safety, and ease of performance, the future of the oral cholecystogram is presently in doubt, principally as a result of the recent advent of gray-scale ultrasound. Ultrasonic techniques, including realtime scanning, have demonstrated remarkable sensitivity and specificity for nearly the entire spectrum of gallbladder disease. In some centers, ultrasonography is now employed as the primary screening technique for detection of gallbladder pathology. Because cholecystosonography may lead to revisions in clinical approaches to diagnosis of gallbladder disease, this review of principles, results, and
Clinical Predictors of Fidelis Lead Failure
Authors: David H. Birnie, Ratika Parkash, Derek V. Exner, Vidal Essebag, Jeffrey S. Healey, Atul Verma, Benoit Coutu, Teresa Kus, Iqwal Mangat, Felix Ayala-Paredes, Pablo Nery, George Wells, Andrew D. Krahn
Journal: Circulation (2012)

Background— Approximately 268 000 Fidelis leads were implanted worldwide until distribution was suspended because of a high rate of early failure. Careful analyses of predictors of increased lead failure hazard are required to help direct future lead design and also to inform decision making on lead replacement. We sought to perform a comprehensive analysis of all potential predictors in a multicenter study. Methods and Results— A total of 3169 Sprint Fidelis leads were implanted in 11 centers with a total of 251 failures. Lead failure rates at 3, 4, and 5 years were 5.3%, 10.6%, and 16.8%, respectively. The rate of lead failure continues to accelerate ( P &lt;0.001). There were 4 independent predictors of failure: center, sex, access vein, and previous lead failure. Women had a higher hazard of failure (hazard ratio 1.51; 95% confidence interval, 1.14–2.04; P =0.005). Both axillary and subclavian access increased the hazard of failure ( P =0.007); hazard ratio for axillary was 1.94, (95% confidence interval, 1.23–3.04) and for subclavian 1.63 (95% confidence interval, 1.08–2.46). Previous lead failure increased the hazard of a subsequent Fidelis failure with a hazard ratio of 3.12 (95% confidence interval, 1.80–5.41; P &lt;0.001). Conclusions— The rate of Fidelis failure continues to increase over time, with failures approaching 17% at 5 years. Women, patients with leads inserted via the subclavian or axillary vein, and those with a previous lead fracture were at greatest risk of Fidelis failure. Our data suggest that Fidelis replacement should be strongly considered at the time of generator replacement.
Hypertension, Hyperreninemia, and Secondary Hyperaldosteronism in Systemic Necrotizing Vasculitis
Authors: RICHARD H. WHITE
Journal: Annals of Internal Medicine (1980)

We studied the pathogenesis of hypertension in two patients with hepatitis-B surface antigen-positive systemic necrotizing vasculitis. Both presented with hypertension, hypokalemia, and renal potassium wasting. Plasma renin activity and urinary aldosterone levels were markedly elevated. Renal arteriograms showed widespread microaneurysms, and necrotizing vasculitis involving renal arteries was confirmed histologically. Hypertension was refractory to conventional treatment in both patients. In one patient, hypertension was easily controlled with the angiotension-converting enzyme inhibitor Captopril. Diffuse renal vasculitis with secondary hyperreninemia and hyperaldosteronism appears to be an important cause of hypertension in patients with systemic necrotizing vasculitis.
Conditional Probability of Long-term Survival After Liver Resection for Intrahepatic Cholangiocarcinoma
Authors: Gaya Spolverato, Yuhree Kim, Aslam Ejaz, Sorin Alexandrescu, Hugo Marques, Luca Aldrighetti, T. Clark Gamblin, Carlo Pulitano, Todd W. Bauer, Feng Shen, Charbel Sandroussi, George Poultsides, Shishir K. Maithel, Timothy M. Pawlik
Journal: JAMA Surgery (2015)

<h3>Importance</h3> Whereas conventional actuarial overall survival (OS) estimates rely exclusively on static factors determined around the time of surgery, conditional survival (CS) estimates take into account the years that a patient has already survived. <h3>Objective</h3> To define the CS of patients following liver resection for intrahepatic cholangiocarcinoma (ICC). <h3>Design, Setting, and Participants</h3> Between January 1, 1990, and December 31, 2013, a total of 535 patients who underwent resection of ICC were identified from an international multi-institutional database. In this retrospective international study conducted from January to June 2014, clinicopathological characteristics, operative details, and long-term survival data were analyzed. Conditional survival estimates were calculated as the probability of survival for an additional 3 years. <h3>Intervention</h3> Resection of ICC. <h3>Main Outcomes and Measures</h3> Overall survival and CS. <h3>Results</h3> While actuarial OS decreased over time from 39% at 3 years to 16% at 8 years (<i>P</i> = .002), the 3-year CS (CS<sub>3</sub>) increased over time among those patients who survived. The CS<sub>3</sub>at 5 years—the probability of surviving to postoperative year 8 after having already survived to postoperative year 5—was 65% compared with 8-year OS of 16% (<i>P</i> = .002). Factors that were associated with worse OS included larger tumor size (hazard ratio [HR], 1.02; 95% CI, 1.00-1.05;<i>P</i> = .05), multifocal disease (HR, 1.49; 95% CI, 1.19-1.86;<i>P</i> = .01), lymph node metastasis (HR, 2.21; 95% CI, 1.67-2.93;<i>P</i> &lt; .01), and vascular invasion (HR, 1.39; 95% CI, 1.10-1.75;<i>P</i> = .006). The calculated CS<sub>3</sub>exceeded the actuarial survival for all high-risk subgroups. For example, patients with lymph node metastasis had an actuarial OS of 11% at 6 years vs a CS<sub>3</sub>of 49% at 3 years (Δ38%). Similarly, patients with vascular invasion had an actuarial OS of 15% at 6 years compared with a CS<sub>3</sub>of 50% at 3 years (Δ35%). <h3>Conclusions and Relevance</h3> Conditional survival estimates may provide critical quantitative information about the changing probability of survival over time among patients undergoing liver resection for ICC. Therefore, such estimates can be of significant value to patients and health care professionals.
Guidelines of the French Society of Digestive Endoscopy: Biliary Stenting
Authors: J. F. Rey, R. Dumas, J. M. Canard, T. Ponchon, D. Sautereau, T. Helbert, J. Escourrou, G. Gay, M. Giovannini, M. Greff, J. C. Grimaud, J. Lapuelle, B. Marchetti, B. Napoleon, L. Palazzo
Journal: Endoscopy (2002)

Since 1988, the Council of the French Society of Digestive Endoscopy has been publishing standards for good practice in endoscopy. These recommendations appear to us to be the best way of achieving better and more rational practice in medicine at present. Produced by a group of experts, and corrected by an even larger expert group, the guidelines are regularly updated in written form to help physicians in decision-making. Michel Greff, M.D., International Secretary, French Society of Digestive Endoscopy
Mutations in UVSSA cause UV-sensitive syndrome and destabilize ERCC6 in transcription-coupled DNA repair
Authors: Xue Zhang, Katsuyoshi Horibata, Masafumi Saijo, Chie Ishigami, Akiko Ukai, Shin-ichiro Kanno, Hidetoshi Tahara, Edward G Neilan, Masamitsu Honma, Takehiko Nohmi, Akira Yasui, Kiyoji Tanaka
Journal: Nature Genetics (2012)
Abstract 121: Identification of tumor suppressive microRNAs in maxillary sinus squamous cell carcinoma based on microRNA expression signature
Authors: Toyoyuki Hanazawa, Nijiro Nohata, Naoko Kikkawa, Muradil Mutallip, Akihiro Katayama, Yasuaki Harabuchi, Yoshitaka Okamoto, Naohiko Seki
Journal: Cancer Research (2011)

Abstract Maxillary sinus squamous cell carcinoma (MSSCC) comprises 2-3% of all cancers of head and neck tumor and the annual incidence rate is 0.5-1.0 per 100,000 populations. After introduction of multimodality treatment comprising radiation therapy along with concomitant intra-arterial chemotherapy, rates of local control was improved. However the prognosis of advanced MSSCC is still worse. The 5-years survival rate of T4 tumors is 50% around. Local recurrence is the most common cause of treatment failure and death. Greater understanding of the molecular oncogenic pathways in MSSCC could help improve diagnosis, therapy, and prevention of the disease. MicroRNAs (miRNAs), non-coding RNA 21-25 nucleotides in length, regulate gene expression primarily at the posttranscriptional level. Growing evidence suggests that miRNAs are aberrantly expressed in many human cancers, and that they play significant roles in carcinogenesis and cancer progression. The expression signature of cancer related miRNAs could contribute as useful biomarkers for diagnosis and improvement of prognosis for MSSCC. No studies have been carried out for the purpose of identifying specific miRNA alterations in MSSCC. In this study, we performed the miRNA expression signature specific to MSSCC by evaluating 749 mature miRNAs expressions in 5 matched pairs of MSSCC tissues and normal maxillary sinus epithelium. A subset of 9 miRNAs was significantly down-regulated in our signature. Gain-of-function analysis revealed that miR-874 was significantly inhibited cell proliferation, suggesting miR-874 has a tumor suppressive function in MSSCC. We are continuing a search of target genes of miR-874 by using genome-wide gene expression analysis. The identification of tumor suppressive miRNAs and their target genes could provide new insights into potential mechanism of MSSCC carcinogenesis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 121. doi:10.1158/1538-7445.AM2011-121
CONTRIBUTION OF BONE MARROW CELLS AND LACK OF EXPRESSION OF THYMOCYTES IN GENETIC CONTROLS OF IMMUNE RESPONSES FOR TWO IMMUNOPOTENT REGIONS WITHIN POLY-(PHE,GLU)-POLY-PRO--POLY-LYS IN INBRED MOUSE STRAINS
Authors: Edna Mozes, G. M. Shearer
Journal: The Journal of Experimental Medicine (1971)

Previous cellular studies on the genetic regulation of immunological responsiveness for two immunopotent regions within the branched chain synthetic polypeptide (Phe, G)-Pro--L demonstrated a direct correlation between the number of detectable immunocompetent splenic precursor cells and the response patterns of SJL, DBA/1, and F(1) mice (21). In order to establish the cellular origin(s) of the genetic defect, the present study first demonstrated that thymus and bone marrow cell cooperation was required for (Phe, G)- and Pro--L-specific immune responses. Secondly, limiting dilution experiments, in which several graded and limiting inocula of marrow cells were mixed with a non-limiting number of 10(8) thymocytes and injected into irradiated, syngeneic recipients, indicated that the low responsiveness of the SJL and DBA/1 strains to the (Phe, G) and Pro--L specificities, respectively, could be attributed to a reduced number of precursor cells found in bone marrow. About five times more marrow precursors were detected in SJL mice for Pro--L than for (Phe, G), whereas about five times as many precursor cells were estimated for (Phe, G) as for Pro--L in the DBA/1 strain. These differences are similar to those obtained using spleen cells from unimmunized SJL and DBA/1 donors (21), and indicate that these genetically determined variations in responsiveness can be accounted for by differences in the frequencies of monospecific populations of immunocompetent cells present in bone marrow. In contrast, limiting dilution transfers of thymocytes or thymus-derived cells with an excess of syngeneic marrow cells resulted in equally frequent (Phe, G) and Pro--L responses for both SJL ad DBA/1 strains. This finding in conjunction with the observation that the generation of (Phe, G)- and Pro--L-specific responses were associated in individual recipients injected with limiting inocula of thymocytes indicated that a single population of thymocytes was stimulated by (Phe,G)-Pro--L. Therefore, it is improbable that the thymic population of immunocompetent cells contributes to expression of these genetically controlled defects.
Knowledge of the Ibero-American Physicians On Anaphylaxis: Results of the Ibero-American Online Survey for Physicians On the Management and Treatment of Anaphylaxis (IOSPTA) - Latin American Society of Allergy, Asthma &amp; Immunology (LASAAI)
Authors: Dirceu Sole, Juan C. Ivancevich, Victoria Cardona
Journal: Journal of Allergy and Clinical Immunology (2013)
Comparing the efficacy of surgical vs. non-surgical options for hand rejuvenation – A systematic review
Authors: Philip Lim, Alex Loh, Charles Loh
Journal: International Journal of Surgery (2013)

Introduction      The efficacy of surgical versus non-surgical options of hand rejuvenation has not been explored in the literature. We present an interesting analysis comparing surgical and non-surgical options for hand rejuvenation with results obtained from a systematic review of the literature available.    Methodology      A Medline search of MeSH term “Hand rejuvenation” was conducted. A total of 83 articles were found and articles containing clinical data on surgical and non-surgical techniques of hand rejuvenation were selected. The selection criteria were that each study contained 5 of more patients and a post intervention follow-up analysis was available. Each study had to refer specifically to a technique of hand rejuvenation alone and not done in combination with separate procedures.     Results      A total of 10 articles were identified and selected. A total of 405 hands were treated using various non-surgical and surgical methods. Non-surgical methods include fillers such as hyaluronic acid, polylactic acid, Juvederm, calcium hydroxylapatite and Dermicol P350G. Surgical methods include the current popular technique of structural fat grafting and skin excision/reduction techniques. Complications are also comparable to each technique.     Conclusion      Surgical techniques appear to have a higher patient satisfaction compared to non-surgical methods but invariably involve different types of complications.
Golytely Preparation for Colonoscopy: 1.5 Liters is Enough for Outpatients
Authors: Mogens Vilien, Margit Rytkønen
Journal: Endoscopy (1990)

In a prospective double-blind study of the effectiveness and patient acceptance of Golytely whole-gut preparation for colonoscopy, 50 consecutive patients were randomly allocated to drink either 1.5 1 (Group I) or 3 1 (Group II). The patients had some slight dietary restrictions, and received mild laxatives on the preceding day. The cleansing result did not differ significantly in the two groups. The result was assessed as “good” in 76 % of cases in Group I (95 % confidence limits 55-91 %) and in 83 % of cases in Group II (95 % confidence limits 63-95 %). In half of the remaining cases in both groups the result was “acceptable” and in the other half “poor”. Patient acceptance did not differ significantly in the two groups. After completion of the randomized study, oral cleansing with 1.5 1 Golytely has been our daily routine. In 42 patients so treated quality of cleansing was good in 81 % (95 % confidence limits 66-91 %), acceptable in 12 %, and poor in 7 %.
An Adrenal Medullary Function Test.
Authors: S. Brunjes
Journal: Annals of Internal Medicine (1961)

s1 May 1961An Adrenal Medullary Function Test.S. Brunjes, M.D., J. E. Hodgman, M.D., J. Nowack, M.D., V. J. Johns Jr., M.D., F.A.C.P.S. Brunjes, M.D.Search for more papers by this author, J. E. Hodgman, M.D.Search for more papers by this author, J. Nowack, M.D.Search for more papers by this author, V. J. Johns Jr., M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-54-5-1043_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough the adrenal medulla is not an essential organ, it is well known that it plays a role in the regulation of blood sugar through the effect of epinephrine on glycogenolysis. At the present time, adrenal medullary insufficiency is just emerging as a recognized syndrome.In 1959, Broberger, Jungner, and Zetterstrom reported several children with "idiopathic spontaneous hypoglycemia of infancy" (McQuarrie's syndrome) whose epinephrine secretion failed to increase after insulin-induced hypoglycemia. They postulated that the cause of the spontaneous fasting hypoglycemia was a failure of the adrenal medulla to increase secretion of epinephrine during hypoglycemia.We have studied six infants... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAdrenal medullary function in idiopathic spontaneous hypoglycemia of infancy and childhoodThe mechanism of arrhythmias during insulin-induced hypoglycemia 1 May 1961Volume 54, Issue 5Page: 1043-1043KeywordsBlood sugarChildrenEpinephrineHypoglycemiaInfantsInsulin secretion ePublished: 1 December 2008 Issue Published: 1 May 1961 PDF downloadLoading ...