tbuckley/cabot-search huggingface dataset:
Targeting PDGF Signaling in Carcinoma-Associated Fibroblasts Controls Cervical Cancer in Mouse Model
Authors: Rakesh K Jain, Johanna Lahdenranta, Dai Fukumura
Journal: PLoS Medicine (2008)

Cervical cancer is one of the most prevalent malignancies in women worldwide and is the leading cause of cancer death for women in developing countries [1]. While early detection via the Pap test as well as treatment by surgery and chemoradiotherapy has reduced mortality from this disease, the prognosis is poor if the disease is detected at an advanced stage [2]. Thus new treatment strategies for cervical cancer are needed.

In this issue of PLoS Medicine, Kristian Pietras and colleagues, using a mouse model of cervical carcinogenesis, provide compelling evidence that targeting platelet-derived growth factor (PDGF) signaling, primarily in carcinoma-associated fibroblasts (CAFs), can slow the progression of this disease and even impair the growth of invasive carcinomas [3]. By offering preliminary evidence for the presence of PDGF receptors in a limited number of human cervical cancer biopsies, these authors also suggest that the drugs approved by the United States Food and Drug Administration (FDA) that target PDGF signaling, such as imatinib mesylate (Gleevec in the US; Glivec in Europe and Australia, Novartis), be tested in the clinic for this malignancy.
Diagnostic Use of Glucagon-Induced Insulin Response
Authors: DINESH KUMAR
Journal: Annals of Internal Medicine (1974)

The intravenous glucagon stimulation test was assessed as a diagnostic tool in the differential diagnosis of hypoglycemia. Six of seven patients with insulinoma had peak insulin values over 130 µU/ml. None of the controls with normal weight or patients with hypoglycemia as a result of other causes had a peak insulin value over 98 µU/ml. In this study and in glucagon tests done by other investigators, the peak insulin responses occurred from 3 to 30 minutes after injection of glucagon. Since this peak is highly transient it may be missed unless sampling is done every 5 minutes for at least 30 minutes. When done properly, this test was positive in over 80% of insulinoma patients. False-negative results occur in patients treated with diazoxide, hydrochlorothiazide, or diphenylhydantoin. False-positive tests may be seen in individuals who are obese or treated with tolbutamide.
Family study of the major histocompatibility complex in patients with systemic lupus erythematosus: importance of null alleles of C4A and C4B in determining disease susceptibility.
Authors: A H Fielder, M J Walport, J R Batchelor, R I Rynes, C M Black, I A Dodi, G R Hughes
Journal: BMJ (1983)

The families of 29 patients with systemic lupus erythematosus and 42 normal subjects were studied to determine the inheritance of the HLA-A, B, C, and DR antigens and also the complement polymorphisms for C2, C4A, C4B, and Bf, which are encoded in the same region of the sixth chromosome. Null (silent) alleles for C4A, C4B, or C2 were found in 24 of the 29 (83%) patients compared with 18 of the 42 (43%) normal controls. HLA-DR3 was present in 20 (69%) of the patients and seven out of 39 (18%) of the normal controls. There was strong linkage disequilibrium between DR3 and the null alleles for C4A and C4B. The data did not permit the relative contributions of DR3 and null factors of C4A and C4B as genetic risk factors to be distinguished. The known association of systemic lupus erythematosus with uncommon inherited and acquired deficiencies of complement components suggests, however, that the presence of null alleles for C4A and C4B, as well as C2, found in most of the patients, is relevant to their genetic susceptibility to this disease.
It's my life: Death notices, obituaries and the departure lounge
Authors: Kamran Abbasi
Journal: Journal of the Royal Society of Medicine (2011)

Would you like your death notice to appear in the JRSM? I'm guessing you would. Beginning in 2012, we will publish death notices each month for members of the Royal Society of Medicine. Family members and friends do not need to send in death notices because we will receive the information about deaths from the RSM's membership department. Our purpose is to share this important news with colleagues and acquaintances that might be otherwise unaware.

But there's more to a life than a line in the JRSM. Death notices are the first step in our publication of obituaries, which we expect will be mostly of RSM members but will also touch on ‘the lives and deaths, careers, foibles and crimes of the good, the bad and the simply famous’, as the Telegraph likes to describe obituaries. Clearly, many RSM members have also been good, bad, and even famous at various times.

To begin with we will rely on you to submit obituaries of friends or relatives. Our aim will be to publish all obituaries of RSM members, either in print or on the JRSM website, to reflect the RSM's multidisciplinary and international membership. We will be more selective in publishing obituaries of non-RSM members, and only publish those about health professionals who have had a significant impact on medicine and healthcare.

An obituary that you submit should be no longer than 200 words, and we might edit it down further depending on space limitations. If it is particularly interesting, we might ask you for more words. Full name, including maiden name, dates of birth and death are essential information that should accompany an obituary. Ideally, too, obituary writers will include a cause of death and a picture. We appreciate that any contributions received will be written at a sensitive time, and will help as much as possible, but we do ask that contributors follow our guidance to ensure publication. We are open to publishing obituaries about deaths from this month onwards.

Death notices and obituaries are well-established in newspapers and some medical journals. True to the spirit of JRSM and the willingness of the medical professions to address death, we won't stop there. Many publications prepare obituaries of important personalities in advance. JRSM will go one step further by inviting health professionals who are prepared to enter the departure lounge, a chance to write their own obituary in advance and read it in JRSM. We'll only publish the best and we will begin in experimental mode to see how authors and readers, friends and foes respond to this new section. Perhaps nobody will dare tempt fate? It's your life, you choose.
Well-Being Therapy: Conceptual and Technical Issues
Authors: Giovanni A. Fava
Journal: Psychotherapy and Psychosomatics (1999)

Well-being therapy is a short-term, well-being-enhancing psychotherapeutic strategy. It is based on Carol D. Ryff’s multidimensional model of psychological well-being, encompassing environmental mastery, personal growth, purpose in life, autonomy, self-acceptance and positive relations with others. Its conceptual and technical issues are described. It may be applied as a relapse-preventive strategy in the residual phase of affective (mood and anxiety) disorders, as an additional ingredient of cognitive behavioral packages, in patients with affective disorders who failed to respond to standard pharmacological and psychotherapeutic treatments, in body image disorders and in psychosomatic medicine. The first validation studies appeared to be promising. The technique is in its preliminary stage of development and may undergo major changes in the next years. It is hoped it may herald a new trend of psychotherapy research and practice in the current symptom-oriented settings.
PITYRIASIS ROSEA WITH LESIONS ON PALMS.
Authors: H. HALDIN-DAVIS
Journal: British Journal of Dermatology (1933)

Journal Article PITYRIASIS ROSEA WITH LESIONS ON PALMS. Get access H. HALDIN‐DAVIS, F R.C.P. H. HALDIN‐DAVIS, F R.C.P. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 45, Issue 2, 1 February 1933, Page 71, https://doi.org/10.1111/j.1365-2133.1933.tb10145.x Published: 01 February 1933
THE ADDRESS OF THE PRESIDENT.
Authors: R. BEVERLY COLE
Journal: JAMA (1896)

Perhaps never before in the history of this Associa- tion has its presiding officer, elevated to his exalted position through the kind suffrage of his confr\l=e`\res, felt at a greater disadvantage than at present.Fully imbued with an appreciation of the dignity and im- portance of the station, and the difficulties attendant upon the proper discharge of the duties that devolve upon him, I must crave your kind indulgence for any errors of judgment as expressed through my rulings, and trust they may be ascribed rather to an excess of ambition to do right than to a willful carelessness or indifference.Fifteen years ago in the beautiful city of Atlanta I was made your First Vice President, my superior officer being the distinguished surgeon of New York, Prof. L. A. Sayre, and I recognize it as an interesting coincidence that it should be my privilege to return to this Athens of the South to round out my official connection with this, our loved institution.Indeed, my present visit is fraught with the greatest interest to observe the great changes that have been wrought in the period, as expressed through the won- derful growth in population and business, whether in manufacture or trade; the evidences of refinement and culture as exhibited in your lovely homes and grand public and private structures, and last, but not least, it is apparent on every side that that generous hospitality for which your people have ever been dis- tinguished has not only not abated, but, if possible, increased in the same ratio with the advances made in every other direction.At the time alluded to these people had but recently passed through the trials, privations and sufferings incidental to a most cruel civil war, than which noth- ing is to be more deplored, the indications of which were more or less noticeable in every surrounding.But, lo! what a change!In lieu of the remains of portentious breastworks and other requirements of physical strife, there has arisen as though through the operations of Aladdin's lamp or some magic wand, this most picturesque and prosperous city, and to-day we, from the North, East and West, again grasp your hands that are so cordially extended with that warmth and unity of purpose that express in silence more than it is possible to utter with the lips.These occasions that bring us annually together serve many purposes.They are in a sense a family reunion, each individual of which is interested in the welfare of the other, and the whole in the one great, noble and God-like object of studying the best methods for alleviating suffering and prolonging life.These
Comparison of Rapid Intravenously and Orally Administered Contrast Mediums for Routine Gall-Bladder Study
Authors: V. Kremens, S. M. Berger, E. M. Cohn
Journal: New England Journal of Medicine (1956)

THIS study was initiated to determine the comparative effectiveness of intravenously administered and orally administered cholecystographic mediums for routine use in x-ray examination of the gall bladder. The recent introduction of iodipamide (disodium N,N-adipyl-bis [3 amino-2,4,6-triiodobenzoate]) solution, 20 per cent iodipamide sodium¶ for nonoperative choledochography and cholecystography stimulated our interest in the use of this substance for routine gall-bladder visualization. No attempt was made to evaluate the applicability of iodipamide for examination of the extrahepatic biliary ducts since this has been discussed in other communications.1 2 3 Methods and MaterialsThe 68 cases studied in this series were selected at random, the . . .
Interferon-α (IFN) induction dosing and ribavirin (R) in IFN non-responders (NR) with chronic hepatitis C (CHC): Interim analysis of an ongoing study (SASL 10)
Authors: E.C. Renner-Schneiter, J-F. Dufour, R. Fried, J.J. Gonvers, M. Knoblauch, P.J. Malè, F. Negro, J. Reichen, C. Rohner, M. Steuerwald, E.L. Renner
Journal: Journal of Hepatology (2000)
Importance of time to reperfusion for 30-day and late survival and recovery of left ventricular function after primary angioplasty for acute myocardial infarction
Authors: Bruce R Brodie, Thomas D Stuckey, Thomas C Wall, Grace Kissling, Charles J Hansen, Denise B Muncy, Richard A Weintraub, Thomas A Kelly
Journal: Journal of the American College of Cardiology (1998)
Eruptive pigmentation around naevi and seborrhoeic keratoses in a patient with stage III melanoma: hyperpigmented halo or ‘Nottus’ phenomenon
Authors: C. Lenormand, B. Cribier, D. Lipsker
Journal: British Journal of Dermatology (2013)

Funding sources: none. Conflicts of interest: none declared. Madam, The appearance of white, vitiligo‐like macules around pigmented moles (Sutton halo naevus or Sutton phenomenon) is a well‐known phenomenon, and has been described in the context of melanoma. We report the case of a man with stage III melanoma who developed a sudden and synchronous, eruptive pigmentation around most of his naevi and seborrhoeic keratoses. A 65‐year‐old man with a medical history of tobacco smoking and dyslipidaemia presented in March 2006 with an extensive subcutaneous mass of the right scapular region, which was resected. Histological examination demonstrated dermal metastasis of melanoma. Thorough skin examination revealed many melanocytic naevi without atypical features and a few seborrhoeic keratoses, but no lesion consistent with primitive cutaneous melanoma. A highly suspect, enlarged, right axillary lymph node was detected and lymph node dissection was performed in December 2006, showing melanoma metastases with extracapsular extension in two of 12 resected lymph nodes. Staging investigations, including a positron‐emission tomography scan and a full body computed tomography (CT) scan, did not detect any visceral metastasis. Adjuvant immunotherapy with interferon alfa‐2a (3 × 3 million IU weekly) was administered, but had to be discontinued 5 months later because of liver enzyme elevation. At a follow‐up visit 6 months after discontinuation of the treatment, a striking modification of his skin lesions was noted. Most of his naevi were surrounded by a light‐brown, ill‐defined, round or oval macular halo (Fig. 1), associated with brownish macules without a central lesion. He had experienced neither pruritus nor perilesional erythema, and his general condition was good. Histological examination of five lesions surrounded by brown macules demonstrated hypermelanosis of the epidermal basal layer without significant melanocytic hyperplasia in the periphery (corresponding to the pigmented halo) (Fig. 2), and a typical compound dermal naevus in the centre. In one sample, the central brown papule corresponded to a seborrhoeic keratosis (not shown). There was no pigmentary incontinence, melanophages, inflammatory cells or fibrosis in the underlying dermis. A full body CT scan at this time did not reveal any visceral metastasis, while urine analysis ruled out melanuria. Regular clinical and paraclinical follow‐up was pursued, allowing the detection in 2010 of a right axillar metastatic lymph node recurrence, treated with lymph node dissection. Since this date, he has remained recurrence free.
Steatosis affects the performance of liver stiffness measurement for fibrosis assessment in patients with genotype 1 chronic hepatitis C
Authors: Fabio Salvatore Macaluso, Marcello Maida, Calogero Cammà, Giuseppe Cabibbo, Daniela Cabibi, Rossella Alduino, Vito Di Marco, Antonio Craxì, Salvatore Petta
Journal: Journal of Hepatology (2014)
Failures at four NHS organisations led to boy's death from sepsis
Authors: C. Dyer
Journal: BMJ (2014)

A three year old boy who died an avoidable death was failed by all four NHS organisations involved in his care in the last days of his life, the parliamentary and health service ombudsman has found.1

Sam Morrish, of Newton Abbott in Devon, died of sepsis on 23 December 2010 after becoming unwell during a flu epidemic. The ombudsman, Julie Mellor, found that he would probably have survived had he not been let down by GPs, the local out of hours GP service, NHS Direct, and South Devon Healthcare NHS Foundation Trust.

“The repeated failures by the NHS when treating Sam undoubtedly caused Mr and Mrs Morrish a …
IMMUNITY TO CANCER
Authors: B. M. Fried
Journal: JAMA (1926)

<h3>To the Editor:</h3> —In a letter from Geneva, Switzerland, about heredity and cancer (The Journal, September 4, p. 771), your correspondent quotes Professor Guyénot to the effect that "in Japanese women, cancer of the breast is rare." Apropos of this apparently widespread belief there was an interesting remark made by the French surgeon and scientist Pierre Delbet at a meeting of the Association française pour l'étude du cancer, April 19, 1926. In discussing a paper on the frequency of cancer, Delbet called attention to the erroneous statements made frequently by statisticians in regard to the incidence of cancer. "Thus," says Delbet, "Hoffman, from an American life insurance company, affirms that Japanese women are practically free from cancer of the breast.... The day following the communication of this important fact in the Academie de médecine, chance brought to my service a prominent Japanese surgeon. When I spoke to him about cancer
Superwarfarin ingestion and detection
Authors: Charles R. Routh, Douglas A. Triplett, Michael J. Murphy, Larry J. Felice, James A. Sadowski, E. G. Ted Bovill
Journal: American Journal of Hematology (1991)

Abstract Because of the emergence of warfarin resistance, new potent long‐acting anticoagulants are now readily available in several over‐the‐counter rodenticide products. The availability of these “superwarfarin” compounds has led to accidental and purposeful human ingestions, one of which has resulted in a death. We summarize the prior case reports and report a second death. In addition, we report the availability of an assay to detect the presence of brodifacoum (a superwarfarin compound) in human plasma and tissues.
Bronchoalveolar Lavage Alterations in Pulmonary Embolism
Authors: GEORGE NAKOS, EIRENE I. KITSIOULI, MARILENA E. LEKKA
Journal: American Journal of Respiratory and Critical Care Medicine (1998)

The objective of this study was to determine quantitative and qualitative surfactant alterations, proteins, and platelet activating factor (PAF) in bronchoalveolar lavage (BAL) fluid from patients with pulmonary thromboembolism (PTE) with respect to ventilated patients without PTE. Patients with PTE underwent BAL at the most affected lung area on the first and tenth days of PTE diagnosis. Total proteins and albumin, total lipids, individual phospholipid classes, PAF and PAF-acetylhydrolase (PAF-AcH) activity were determined in BAL fluid. Total proteins and albumin were found to be increased in both successive samples of patients with PTE when compared with the control group (p < 0.001 and p < 0.05, respectively). Total phospholipids, though, were elevated on the first day, but they decreased on the tenth day, in comparison with the control groups (p < 0.05). Alterations in the percentage of individual phospholipid classes were observed in both successive samples of BAL fluid when compared with those in the control subjects. PAF and PAF-AcH were detected in high levels on the first day (p < 0.001), which were reduced on the tenth day (p < 0.05). An inverse correlation between PAF levels and PaO2 /Fi O2 ratio was observed. Finally, the percentage of macrophages decreased and the percentage of neutrophils increased during the course of PTE. In conclusion, pulmonary embolism is associated with alterations in lung surfactant and inflammation in lung tissue, expressed by an increase in PAF and in neutrophils.
Endogenous Antimicrobial Peptides and Skin Infections in Atopic Dermatitis
Authors: Peck Y. Ong, Takaaki Ohtake, Corinne Brandt, Ian Strickland, Mark Boguniewicz, Tomas Ganz, Richard L. Gallo, Donald Y.M. Leung
Journal: New England Journal of Medicine (2002)

The innate immune system of human skin contains antimicrobial peptides known as cathelicidins (LL-37) and β-defensins. In normal skin these peptides are negligible, but they accumulate in skin affected by inflammatory diseases such as psoriasis. We compared the levels of expression of LL-37 and human β-defensin 2 (HBD-2) in inflamed skin from patients with atopic dermatitis and from those with psoriasis.
Abstract 212: gp78/AMFR is involved in ubiquitination of PGI/AMF
Authors: Ying Wang, Youming Xie, Pratima Nangia-Makker, Vitaly Balan, Avraham Raz
Journal: Cancer Research (2012)

Abstract Phosphoglucose isomerase/autocrine motility factor (PGI/AMF) is a multifunctional protein that intracellularly catalyzes the interconversion of glucose 6-phosphate and fructose 6-phosphate in both glycolytic and gluconeogenesis pathways and extracellularly acts as a cytokine associated with aggressive tumor phenotype. Secreted PGI/AMF promotes cancer cell invasion and metastasis by stimulating cell motility via an autocrine manner following binding to its seven-transmembrane glycoprotein receptor gp78/AMFR. Gp78/AMFR also demonstrates an additional function in the endoplasmic reticulum (ER) as ubiquitin ligase (E3). Thus, gp78/AMFR represents a potential link between ubiquitination, ER-associated degradation (ERAD) and metastasis. We questioned if gp78/AMFR is involved in the ubiquitination of PGI/AMF, and whether the ubiquitinated PGI/AMF can be related to cancer progression and metastasis. In this study, we found that indeed PGI/AMF can be ubiquitinated and gp78/AMFR is involved in this process. PGI/AMF was predominantly ubiquitinated via K29-linked ubiquitin chains. Monoubiquitinated PGI/AMF increases the secretion of PGI/AMF and this is the first report to show that monoubiquitinated PGI/AMF is secreted out of the cells. As secretion of PGI/AMF plays a significant role in tumor cell migration and invasion during metastasis, these studies assist in understanding the regulation of PGI/AMF and the mechanisms of its secretion, which may provide a new therapeutic target for tumor metastasis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 212. doi:1538-7445.AM2012-212
Rifampicin-induced non-responsiveness to corticosteroid treatment in nephrotic syndrome.
Authors: W Hendrickse, J McKiernan, M Pickup, J Lowe
Journal: BMJ (1979)

Rifampicin-induced non-responsiveness to corticosteroid treatment in nephrotic syndromeThe nephrotic syndrome in childhood is usually of the minimal-change variety.At least 95% of children with this lesion respond to adequate corticosteroid treatment.Failure to respond is an indication for renal biopsy to exclude a more sinister glomerular lesion.We report the case of a boy whose failure to respond was not due to progressive glomerular disease but to a drug interaction.Case report
Adapalene 0·1% gel has low skin irritation potential even when applied immediately after washing
Authors: None Dunlap, None Baker, None Plott, None Verschoore
Journal: British Journal of Dermatology (1998)

The purpose of this study was to evaluate the difference, if any, in facial skin tolerance of adapalene 0·1% gel applied immediately after washing, compared to delayed application as recommended for the other topical retinoids: tretinoin and isotretinoin. Twenty‐five acne patients with mild to moderate acne vulgaris were included in this intra individual randomized comparison study where adapalene 0·1% gel was applied immediately after washing on one half of the face and 20–30 min after washing on the contralateral half‐face, for 22 consecutive days. No difference between the two regimens was detected by the investigator or by 21 of the 22 patients who completed the study. It was concluded that application of adapalene gel 0·1% is well tolerated even when applied immediately after washing.