Right Ventricular Unloading: Lessons from the Left
Authors: Joseph A. Franciosa, Herbert A. Fischer
Journal: Annals of Internal Medicine (1981)

Editorials1 November 1981Right Ventricular Unloading: Lessons from the LeftJOSEPH A. FRANCIOSA, M.D., HERBERT A. FISCHER, M.D.JOSEPH A. FRANCIOSA, M.D.Search for more papers by this author, HERBERT A. FISCHER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-95-5-647 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe notion of using vasodilators for primary pulmonary hypertension is not new, but interest in such treatment has increased, perhaps because of the success achieved with impedance reducing therapy for left ventricular failure. Beneficial hemodynamic effects with vasodilators such as hydralazine or diazoxide have been reported (1-3), and one report has suggested that phentolamine may produce similar effects in patients with primary pulmonary hypertension (4). Others, however, have not shown these agents to be beneficial in similar patients (5), and Cohen and Kronzon (6) in this issue report not only that phentolamine was not beneficial in a patient with primary...References1. RUBINPETER LR. Oral hydralazine therapy for primary pulmonary hypertension. N Engl J Med. 1980;302:70-3. CrossrefGoogle Scholar2. WANGPOHROWLANDSWADE SJDE. Diazoxide in treatment of primary pulmonary hypertension. Br Heart J. 1978;40:572-4. CrossrefMedlineGoogle Scholar3. KLINKEGILBERT WJ. Diazoxide in primary pulmonary hypertension. N Engl J Med. 1980;302:91-2. CrossrefMedlineGoogle Scholar4. RUSKINHUTTER JA. Primary pulmonary hypertension treated with oral phentolamine. Ann Intern Med. 1979;90:772-4. LinkGoogle Scholar5. FRIPPGEWITZWERNERWHITMANRASHKIND RMJVW. Oral hydralazine in patients with pulmonary vascular disease secondary to congenital heart disease. Am J Cardiol. 1981;48:380-2. CrossrefMedlineGoogle Scholar6. COHENKRONZON MI. Adverse hemodynamic effects of phentolamine in primary pulmonary hypertension. Ann Intern Med. 1981;95:591-2. LinkGoogle Scholar7. WAGENVOORTWAGENVOORT CN. Primary pulmonary hypertension: a pathologic study of the lung vessels in 156 clinically diagnosed cases. Circulation. 1970;42:1163-84. CrossrefGoogle Scholar8. MOORE-JONESPERRY DH. Radioautographic localization of hydralazine-1-C14 in arterial walls. Proc Soc Exp Biol Med. 1966;122:576-9. CrossrefMedlineGoogle Scholar9. ATKINSMITCHELLPETTINGER JHW. Increased pulmonary vascular resistance with systemic hypertension: effect of minoxidil and other antihypertensive agents. Am J Cardiol. 1977;39:802-7. CrossrefMedlineGoogle Scholar10. FRANCIOSAWILEN JM. Mechanisms of exercise limitation in patients with left ventricular failure. Clin Res. 1980;28:756A. Abstract. Google Scholar11. KANEMOTOSASAMOTO NH. Pulmonary hemodynamics in primary pulmonary hypertension. Jap Heart J. 1979;20:395-405. CrossrefMedlineGoogle Scholar12. FRANCIOSAPARKLEVINE JMT. Lack of correlation between exercise capacity and indexes of resting left ventricular performance in heart failure. Am J Cardiol. 1981;47:33-9. CrossrefMedlineGoogle Scholar13. BOURDILLONOAKLEY PC. Regression of primary pulmonary hypertension. Br Heart J. 1976;38:264-70. CrossrefMedlineGoogle Scholar14. SUAREZSCIANDROLLERAPEROSIO LEJA. Long-term follow-up in primary pulmonary hypertension. Br Heart J. 1979;41:702-8. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByShort- and Long-term Hemodynamic Effects of Oral Nifedipine in Patients with Pulmonary Hypertension Secondary to COPD and Lung FibrosisVasodilating Drugs and Regional CirculationChronic Obstructive Pulmonary DiseaseVasodilator Therapy for Primary Pulmonary Hypertension Limitations and HazardsMILTON PACKER, M. D.Comparative actions of hydralazine, nifedipine and amrinone in primary pulmonary hypertensionOral Nifedipine in Chronic Cor Pulmonale Secondary to Severe Chronic Obstructive Pulmonary Disease (COPD)Acute Hemodynamic Effects of Nitroglycerin in Pulmonary HypertensionRONALD G. PEARL, M.D., MYER H. ROSENTHAL, M.D., JOHN S. SCHROEDER, M.D., J. P. A. ASHTON, C.P.T.Contrasting acute effects of vasodilators (nitroglycerin, nitroprusside, and hydralazine) on right ventricular performance in patients with chronic obstructive pulmonary disease and pulmonary hypertension: A combined radionuclide-hemodynamic studyPulmonary Aspects of Aging 1 November 1981Volume 95, Issue 5Page: 647-648KeywordsHemodynamicsPulmonary hypertensionVasodilators Issue Published: 1 November 1981 PDF DownloadLoading ...