tbuckley/cabot-search huggingface dataset:
Cancer and Upper Gastrointestinal Tract Hemorrhage
Authors: Charles J. Lightdale
Journal: JAMA (1973)

The sources of upper gastrointestinal tract bleeding have been documented by endoscopy in 81 patients studied prospectively at Memorial Sloan-Kettering Cancer Center from 1969 to 1972. Hemorrhagic gastritis was most common cause of bleeding overall in 38 patients (47%), followed by chronic peptic ulcer disease in 18 patients (22%). Bleeding directly from tumor was present in only 10 patients (12%). Eighteen stomach tumors were seen endoscopically, but only ten were bleeding. Primary gastric carcinoma and secondary gastric lymphoma were likely to be the origin of hemorrhage, while other metastatic tumors were unlikely sources. Stress ulcers were important, accounting for more than half of the hemorrhagic gastritis in patients with malignant disease. The remaining cases of gastritis were associated with exogenous gastric irritants. These results indicate need for aggressive diagnostic approaches, with early endoscopy for patients with cancer who develop upper gastrointestinal tract bleeding.
Bet v 1–specific T-cell receptor/forkhead box protein 3 transgenic T cells suppress Bet v 1–specific T-cell effector function in an activation-dependent manner
Authors: Klaus G. Schmetterer, Daniela Haiderer, Victoria M. Leb-Reichl, Alina Neunkirchner, Beatrice Jahn-Schmid, Hans J. Küng, Karina Schuch, Peter Steinberger, Barbara Bohle, Winfried F. Pickl
Journal: Journal of Allergy and Clinical Immunology (2011)
Integrin α<sub>3</sub>Mutations with Kidney, Lung, and Skin Disease
Authors: Cristina Has, Giuseppina Spartà, Dimitra Kiritsi, Lisa Weibel, Alexander Moeller, Virginia Vega-Warner, Aoife Waters, Yinghong He, Yair Anikster, Philipp Esser, Beate K. Straub, Ingrid Hausser, Detlef Bockenhauer, Benjamin Dekel, Friedhelm Hildebrandt, Leena Bruckner-Tuderman, Guido F. Laube
Journal: New England Journal of Medicine (2012)

Integrin α(3) is a transmembrane integrin receptor subunit that mediates signals between the cells and their microenvironment. We identified three patients with homozygous mutations in the integrin α(3) gene that were associated with disrupted basement-membrane structures and compromised barrier functions in kidney, lung, and skin. The patients had a multiorgan disorder that included congenital nephrotic syndrome, interstitial lung disease, and epidermolysis bullosa. The renal and respiratory features predominated, and the lung involvement accounted for the lethal course of the disease. Although skin fragility was mild, it provided clues to the diagnosis.
B-lymphocytes activation by the Fc region of IgG.
Authors: M A Berman, W O Weigle
Journal: The Journal of Experimental Medicine (1977)

Strong stimulation of DNA synthesis (up to 150-fold) and blast transformation can be induced in mouse spleen cells by Fc fragments of human IgG. The mitogenic response is optimal on day 5 of culture and is dependent on the concentration of Fc fragments with a sedimentation rate of 3-5S. Intact IgG is also stimulatory, but only when modified by heat aggregation, and produces only a 10-fold increase in [3H]thymidine uptake. The stimulation by aggregated IgG is dependent on the Fc portion, since aggregated (or soluble) Fab or F(ab')2 fragments are inactive. The results show that the response is T-cell independent and that it is a function of nylon wool adherent, surface Ig-positive, Fc receptor-bearing B lymphocytes. Fc fragments do not induce plaque-forming cells to human IgG in normal mouse spleen cell cultures, but rather trigger polyclonal antibody synthesis (anti-goat erythrocytes, anti-2,4,6-trinitrophenyl). It is postulated that the Fc region of antibodies plays a role in the regulation of the humoral immune response by triggering clonal expansion of B lymphocytes.
Roderick John Kilner Brown
Authors: C. Strallen
Journal: BMJ (2008)

After active service in India and Burma from 1943 until 1946, Roderick John Kilner Brown trained in paediatrics in Birmingham. He worked as a paediatrician at King’s College Hospital, London, and the Department of Child Health, Cardiff, before being appointed consultant paediatrician to the Hackney Group of Hospitals, including the Queen Elizabeth Hospital, in 1959, and the Middlesex …
Plasma Neurotransmitters and Functional Illness (Part 2 of 3)
Authors: Fuad Lechin, Bertha van der Dijs, Marcel E. Lechin
Journal: Psychotherapy and Psychosomatics (1996)

Although the concept of functional illness has blurred boundaries, some consensus exists on its understanding among clinicians. In short, it is easier to conceive than to define functional illness. Semantic and conceptual discussion concerning this issue have been endless. Many links exist that connect brain and body (mind and organs, psyche and soma). Amongst them, neurotransmitters, released by peripheral neurons and some glandular cells (adrenal, enterochromaffm cells, mast cells), are diverted into the bloodstream. Although neurotransmitters cannot cross the blood-brain barrier, basic and clinical research has progressively established the relationship between central and peripheral neurochemical activities. Hence, it is possible to obtain some approach to the central profile through the measurement of circulating neurotransmitters. However, this approach is more reliable if we can measure all circulating factors and, in addition, test the responses to different kinds of challenges (stressors, drugs, etc.). All diseases (somatic, psychiatric and psychosomatic) present some kind of plasma neurotransmitter disturbance; however, only in some has the whole abnormal profile been established. Technical difficulties as well as expensive procedures have interfered with the generalization of this research area. In the present review article, we summarize data quoted from current scientific literature reporting exhaustive research in this area.
Downsides of Robot-assisted Laparoscopic Radical Prostatectomy: Limitations and Complications
Authors: Declan G. Murphy, Anders Bjartell, Vincenzo Ficarra, Markus Graefen, Alexander Haese, Rodolfo Montironi, Francesco Montorsi, Judd W. Moul, Giacomo Novara, Guido Sauter, Tullio Sulser, Henk van der Poel
Journal: European Urology (2009)
Controlled trial of filgrastim for acceleration of neutrophil recovery after allogeneic blood stem cell transplantation from human leukocyte antigen–matched related donors
Authors: Donna Przepiorka, Terry L. Smith, Jody Folloder, Paolo Anderlini, Ka-Wah Chan, Martin Körbling, Benjamin Lichtiger, Frank Norfleet, Richard Champlin
Journal: Blood (2001)
ANOTHER TREATMENT FOR ATHLETE'S FOOT
Authors: J. R. Crawford
Journal: JAMA (1931)

<h3>To the Editor:</h3> —In the many years that I was in general practice at Salina, Kan., I saw the average number of dermatoses, and treated them in the usual methods with the usual good results. However, during the past summer I had my first personal experience with so-called athlete's foot, which became progressively worse under treatment. Finally, realizing that gasoline is a most active fungicide, in desperation I immersed my feet for six to eight seconds in ordinary commercial "gas," with practically instantaneous relief. While I repeated this foot bath the next day, the irritation had in no way recurred, nor has it to date. Because I have no way of carrying this observation further, since I am on the retired list, and because I believe this observation might be of interest to others, I am asking you to include this in your correspondence column. I should be pleased to
Dropouts in sublingual allergen immunotherapy trials – a systematic review
Authors: M. Makatsori, G. W. Scadding, C. Lombardo, G. Bisoffi, E. Ridolo, S. R. Durham, G. Senna
Journal: Allergy (2014)

Abstract Participant dropouts can reduce the power of allergen immunotherapy clinical trials. Evaluation of the dropout rate and reasons for dropout are important not only in the planning of clinical studies but are also relevant for adherence to immunotherapy in daily clinical practice. A systematic review was carried out in order to establish the overall dropout rate among published double‐blind, placebo‐controlled randomized clinical trials of sublingual immunotherapy for respiratory allergic diseases. Dropouts were analysed in regards to allergen, formulation, treatment schedule, participant age, study size, number of centres and type of allergic disease. Relative dropout rates in placebo and active groups as well as reasons for dropout were also assessed. A total of 81 studies, comprising 9998 patients, were included. Dropout rates in sublingual immunotherapy controlled studies do not appear to be a major problem with a composite dropout percentage of 14% (95% CI :11.9–16). Furthermore, they are not different for active compared to placebo‐treated participants. This lends support to the positive clinical outcomes seen in meta‐analyses of these trials.
Pfizer to sponsor European impotence awareness campaign
Authors: G. Yamey
Journal: BMJ (2000)

Pfizer, the manufacturer of sildenafil (Viagra), is to launch a Europe-wide “disease awareness” campaign, focusing on treatments for erectile dysfunction without naming its product. The advertising of prescription drugs directly to consumers is banned in the United Kingdom, but pharmaceutical companies are testing the limits of this ban. Last year a television commercial about …
Peripheral Arterial Disease and Metals in Urine and Blood
Authors: Michelle Plusquin, Tim S. Nawrot, Jan A. Staessen
Journal: Environmental Health Perspectives (2005)

scientific methods focus primarily on parts of a large system, not on the large system itself.Another dimension of this change in focus is the development of "joining edge" research, in which leading ideas and best practices from multiple disciplines are brought together in a collaborative effort to examine large, complex systems.This approach complements the more familiar pursuit of progressively narrowing "cuttingedge" research of components of a whole system (Cairns 2003;Kriebel et al. 2001).Perhaps, scientific data to advance human understanding about why globalscale human activities and systems are sustainable or unsustainable could be vital to protecting humanity from endangerment, biodiversity from extinction, and Earth from irreversible degradation, even in these early years of the 21st century.
Fluctuation of Arterial Blood Pressure in Asthma
Authors: K. A. J. Jarvinen
Journal: BMJ (1957)

There is no evidence that any danger may arise from the use of hypnosis in medical treatment.There is no special " gift " required to induce hypnosis.The general practitioner is particularly well suited to use hypnosis as a method of treatment, as he is usually familiar with the patient's background and has his con- fidence, which is important for successful hypnotherapy.
THE THERAPEUTICS OF TUBERCULOSIS OF THE SKIN.
Authors: GRANVILLE MAC GOWAN
Journal: JAMA (1907)

It may be deemed axiomatic that wherever tubercle bacilli find a resting place in an organism and there set up their characteristic histologic changes, if the focus be so localized that it may be removed entirely, by any agency whatever, this removal will constitute a cure of the disease. On the recognition of this depends the value of any treatment for tuberculous lesions of the skin. Careful study of microscopic sections of infiltrative types of lupus immediately shows why many of the measures proposed for treatment have no value, except as mere palliatives for some of the annoying symptoms. I have too often seen the claim of a cure made when all that had been accomplished was the temporary healing of an ulcerating surface, the claimant being entirely unaware that a non-ulcerating patch of lupus is often more difficult to get rid of than one that has already broken down.
C-Reactive Protein as a Predictor of Infarct Expansion and Cardiac Rupture After a First Q-Wave Acute Myocardial Infarction
Authors: Toshihisa Anzai, Tsutomu Yoshikawa, Hiroto Shiraki, Yasushi Asakura, Makoto Akaishi, Hideo Mitamura, Satoshi Ogawa
Journal: Circulation (1997)

Background Pump failure after acute myocardial infarction (AMI) can be predicted by several indices that estimate infarct size. However, there are few indices that predict infarct expansion and cardiac rupture. We focused on the prognostic significance of serum C-reactive protein (CRP) after AMI. Methods and Results Serum CRP levels were measured every 24 hours in 220 patients with a first Q-wave AMI. In-hospital complications, predischarge left ventriculographic findings, and long-term prognosis were assessed in relation to peak CRP levels. Peak levels of both CRP and creatine kinase (CK) were higher in patients with pump failure than in those without pump failure. In patients with cardiac rupture, peak CRP levels were higher than in those without rupture ( P =.001); peak CK levels were not predictive. Higher CRP levels were found in patients with left ventricular aneurysm ( P =.001 versus those without), aggravated heart failure ( P =.03 versus those without), and cardiac death ( P &lt;.0001 versus survivors) during the first year after AMI. Multivariate analysis confirmed that an elevation of the peak CRP level ≥20 mg/dL was an independent predictor of cardiac rupture (relative risk, 4.72; P =.004), left ventricular aneurysmal formation (relative risk, 2.11; P =.03), and 1-year cardiac death (relative risk, 3.44; P &lt;.0001). Conclusions Cardiac rupture, left ventricular aneurysmal formation, and 1-year cardiac death were associated with an elevation of serum CRP early after AMI, suggesting that elevation of CRP levels after AMI may predict infarct expansion.
Cost of Health Care and the Role of Physicians—Reply
Authors: James R. Webster
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
What Is Internal Medicine?
Authors: Herbert Kaplan
Journal: Annals of Internal Medicine (1993)

Letters15 September 1993What Is Internal Medicine?Herbert Kaplan, MDHerbert Kaplan, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-6-199309150-00041 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I immensely enjoyed the article by Dr. LaCombe [1]. It embodied those ideals and goals that I believe are of central importance in the practice of medicine.The statement, our profession is a way of life itself, nothing else comes close, has already made it easier for me to handle some of the mundane choices of everyday red tape. Like Dr. LaCombe, I am an internist, but I am a subspecialist (pulmonologist); still, 50% of my practice is general internal medicine because I love it, especially when I see a patient in our emergency room whose being ...REFERENCE1. LaCombe M. What is internal medicine? Ann Intern Med. 1993; 118: 384-7. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 September 1993Volume 119, Issue 6Page: 541-542KeywordsEmergency departmentSub-specialty care ePublished: 15 August 2000 Issue Published: 15 September 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Successful endoscopic treatment of spontaneous perforation of the common hepatic duct
Authors: J. Karvonen, R. Gullichsen, P. Salminen, S. Laine, J. Grönroos
Journal: Endoscopy (2009)

Perforations of the biliary tract usually occur in the gallbladder as a complication of acute cholecystitis. Spontaneous perforation of the extrahepatic biliary tract is a rare entity, reported usually in infants and associated with congenital anomalies. Here we report the first case of spontaneous perforation of a common hepatic duct, treated successfully with percutaneous drainage and endoscopic stenting.
Ryanodine receptors decant internal Ca2+ store in human and bovine airway smooth muscle
Authors: T. Tazzeo, Y. Zhang, S. Keshavjee, L. J. Janssen
Journal: European Respiratory Journal (2008)

Several putative roles for ryanodine receptors (RyR) were investigated in human and bovine airway smooth muscle. Changes in intracellular Ca 2+ concentration ([Ca 2+ ] i ) and membrane current were investigated in single cells by confocal fluorimetry and patch-clamp electrophysiology, respectively, whereas mechanical activity was monitored in intact strips with force transducers. RyR released Ca 2+ from the sarcoplasmic reticulum in a ryanodine- and chloroethyl phenol (CEP)-sensitive fashion. Neither ryanodine nor CEP inhibited responses to KCl, cholinergic agonists or serotonin, indicating no direct role for RyR in contraction; in fact, there was some augmentation of these responses. In tissues pre-contracted with carbachol, the concentration–response relationships for isoproterenol and salmeterol were unaffected by ryanodine; relaxations due to a nitric oxide donor were also largely unaffected. Finally, it was examined whether RyR were involved in regulating [Ca 2+ ] i within the subplasmalemmal space using patch-clamp electrophysiology as well as Ca 2+ fluorimetry: isoproterenol increased [Ca 2+ ] i - and Ca 2+ -dependent K + current activity in a ryanodine-sensitive fashion. In conclusion, ryanodine receptors in airway smooth muscle are not important in directly mediating contraction or relaxation. The current authors speculate instead that these allow the sarcoplasmic reticulum to release Ca 2+ towards the plasmalemma (to unload an overly full Ca 2+ store and/or increase the Ca 2+ -buffering capacity of the sarcoplasmic reticulum) without affecting bronchomotor tone.
Reply to I. Floriani et al
Authors: Thomas J. Lynch, Shirin Khambata-Ford
Journal: Journal of Clinical Oncology (2010)

The authors point out that both the FLEX (First-Line Erbitux in Lung Cancer) and the BMS-099 (Bristol-Myers Squibb-099) trials are consistent in showing a small benefit of adding cetuximab to chemotherapy for patients with advanced non-small-cell lung cancer (NSCLC); however, only the FLEX study reached its primary end point of showing a significant improvement in overall survival when cetuximab is added to first-line chemotherapy.We also share their strong concern that a biomarker is needed to select which patients with advanced lung cancer benefit from this treatment approach.There are limitations to biomarker analyses that are based on a small subset of patients.The available samples from any one trial are indeed small and may only permit hypothesis generation.However, if any of the markers had strong enough predictive potential to be useful clinically, it is improbable that no (positive) relationship would be seen in any of the trials (FLEX, BMS-099, and so on).The size of the data set was large enough to show an interaction trend if the predictive effect of a marker were of the same magnitude as the mutation status of the KRAS gene in metastatic colorectal cancer (CRC).Unlike as seen in some of the CRC studies, few (Ͻ 30%) patients with lung cancer have samples available for study, as sample collection is generally optional.The small number of patients in the mutationpositive group is an additional limitation.We would like to point out that EGFR mutation analysis was carried out in 166 patients, not in only 15 patients as stated in the letter.Future NSCLC trials should mandate tissue collection as a condition of study entry.Only with adequate tissue will we be able to discover and validate predictive biomarkers that will optimize patient selection for targeted therapies.
Superficial X-ray therapy in the treatment of constitutional eczema of the hands
Authors: G.M. FAIRRIS, D. PATRICIA MACK, N.R. ROWELL
Journal: British Journal of Dermatology (1984)

Journal Article Superficial X‐ray therapy in the treatment of constitutional eczema of the hands Get access G.M. FAIRRIS, G.M. FAIRRIS Department of Dermatology, The General Infirmary at Leeds, Leeds, U.K. Search for other works by this author on: Oxford Academic Google Scholar D. PATRICIA MACK, D. PATRICIA MACK Department of Dermatology, The General Infirmary at Leeds, Leeds, U.K. Search for other works by this author on: Oxford Academic Google Scholar N.R. ROWELL N.R. ROWELL Department of Dermatology, The General Infirmary at Leeds, Leeds, U.K. Dr N.R. Rowell, Department of Dermatology, The General Infirmary at Leeds, Great George Street, Leeds, Yorkshire, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 111, Issue 4, 1 October 1984, Pages 445–449, https://doi.org/10.1111/j.1365-2133.1984.tb06607.x Published: 01 October 1984 Article history Accepted: 23 March 1984 Published: 01 October 1984
Galectin-1 mediated suppression of Epstein-Barr virus–specific T-cell immunity in classic Hodgkin lymphoma
Authors: Maher K. Gandhi, Guido Moll, Corey Smith, Ujjwal Dua, Eleanore Lambley, Olivier Ramuz, Devinder Gill, Paula Marlton, John F. Seymour, Rajiv Khanna
Journal: Blood (2007)
Shades of Methuselah
Authors: Samuel Vaisrub
Journal: JAMA (1978)

Heritable deviations from the norm generally evoke visions of Garrod's "inborn errors of metabolism," with their attendant deformities and diseases. We see them as calamities inflicted on the afflicted and as threats to future generations. Their only redeeming feature is heuristic value. Genetic aberrations are "experiments of nature" from which we may gain insights into normal metabolic processes. Thus, it comes as a happy surprise to chance on a departure from the genetic norm that can be beneficial to the affected person. It is particularly gratifying to find such a departure in an area that is usually linked with coronary heart disease—the area of lipoprotein-cholesterol metabolism. While attention has focused mainly on the positive correlation of coronary heart disease, with increased plasma levels of low-density (β) lipoprotein-cholesterol and decreased levels of high-density (a) lipoprotein-cholesterol, the reported<sup>1,2</sup>negative correlations between the incidence of the disease and the opposite distribution of
The Newell Test should commit to diagnosing dysfunctions
Authors: William J. Clancey
Journal: Behavioral and Brain Sciences (2003)

“Conceptual coordination” analysis bridges connectionism and symbolic approaches by positing a “process memory” by which categories are physically coordinated (as neural networks) in time. Focusing on dysfunctions and odd behaviors, like slips, reveals the function of consciousness, especially constructive processes that are often taken for granted, which are different from conventional programming constructs. Newell strongly endorsed identifying architectural limits; the heuristic of “diagnose unusual behaviors” will provide targets of opportunity that greatly strengthen the Newell Test.