The Hungry Bone Syndrome after Medical Treatment of Thyrotoxicosis
Authors: Marvin Grieff
Journal: Annals of Internal Medicine (2003)

Letters21 October 2003The Hungry Bone Syndrome after Medical Treatment of ThyrotoxicosisMarvin Grieff, MDMarvin Grieff, MDFrom Rochester General Hospital, Rochester, NY 14621.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-139-8-200310210-00027 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Background: Hypocalcemia is a common complication of surgical therapy for thyrotoxicosis. The pathogenesis of the hypocalcemia is controversial; it is often attributed to hypoparathyroidism, but inadequate parathyroid hormone levels are not always found (1, 2). Hypocalcemia due to the hungry bone syndrome often complicates surgical parathyroidectomy for hyperparathyroidism (3). Unapposed bone formation, with decreased bone resorptive activity due to removal of the excess parathyroid hormone, results in hypocalcemia. To our knowledge, following is the first description of the hungry bone syndrome causing hypocalcemia after medical treatment of thyrotoxicosis.Case Report: A 61-year-old woman with a history of ...References1. See AC, Soo KC. Hypocalcaemia following thyroidectomy for thyrotoxicosis. Br J Surg. 1997;84:95-7. [PMID: 9043468] MedlineGoogle Scholar2. Michie W, Duncan T, Hamer-Hodges DW, Bewsher PD, Stowers JM, Pegg CA, . Mechanism of hypocalcaemia after thyroidectomy for thyrotoxicosis. Lancet. 1971;1:508-14. [PMID: 4100433] CrossrefMedlineGoogle Scholar3. Holick MF, Stewart AF. 1999 Miscellaneous causes of hypocalcemia.. In: Favus MJ, eds. Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. 4th ed. Lippincott Williams & Wilkins Philadelphia 238-41. Google Scholar4. Baran T. 2000 The skeletal system in thyrotoxicosis.. In: Braverman LE, Utiger RD, eds. Werner and Ingbar's The Thyroid: A Fundamental and Clinical Text. 8th ed. Lippincott Williams & Wilkins Philadelphia 659-66. Google Scholar5. Diamond T, Vine J, Smart R, Butler P. Thyrotoxic bone disease in women: a potentially reversible disorder. Ann Intern Med. 1994;120:8-11. [PMID: 8250460] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Rochester General Hospital, Rochester, NY 14621. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThyrotoxic Bone Disease in Women: A Potentially Reversible Disorder Terrence Diamond , Julie Vine , Richard Smart , and Patrick Butler Metrics Cited ByBiochemical bone turnover markers in hormonal disorders in adults: a narrative reviewTHERAPY OF ENDOCRINE DISEASE: Hungry bone syndrome: still a challenge in the post-operative management of primary hyperparathyroidism: a systematic review of the literatureEndocrine Complications of Head and Neck SurgeryThyroidectomy for Graves' Disease: A Case-Control StudyHypocalcaemia following therapy of thyrotoxicosis in an infant 21 October 2003Volume 139, Issue 8Page: 706-707KeywordsBoneBone densityCalciumHyperparathyroidismHypocalcemiaParathyroid hormoneParathyroidectomyPhosphatasesResearch laboratoriesThyroid-stimulating hormone ePublished: 21 October 2003 Issue Published: 21 October 2003 CopyrightCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...