tbuckley/cabot-search huggingface dataset:
Abstract 399: Elevation of angiopoietin-like protein 4 by PGE2 and hypoxia promotes colorectal cancer progression
Authors: Sun-Hee Kim, Yun-Yong Park, Sang-Wook Kim, Ju-Seog Lee, Dingzhi Wang, Raymond N. DuBois
Journal: Cancer Research (2011)

Abstract Prostaglandin E2 (PGE2), the most abundant COX-2-derived prostaglandin found in colorectal cancers, promotes tumor cell proliferation and survival via multiple signaling pathways. However, the role of PGE2 in tumor hypoxia is not well understood. Here, we show that a synergistic effect of PGE2 and hypoxia on enhancing ANGPTL4 expression and that elevation of ANGPTL4 promotes colorectal cancer progression. PGE2 induces ANGPTL4 expression at both the mRNA and protein levels under hypoxic conditions. Moreover, hypoxia induces one of the prostaglandin receptors, known as EP1. Activation of EP1 enhances ANGPTL4 expression, whereas blockage of EP1 by its antagonist inhibits PGE2 induction of ANGPTL4 under hypoxic conditions. Over-expression of ANGPTL4 promotes cell proliferation and tumor growth in vivo. In addition, treatment with ANGPTL4 recombinant protein increases cancer cell proliferation through stimulating STAT1 activation. These findings are relevant to human disease since we found that the expression of ANGPTL4 and STAT1 are elevated in 50% of human colorectal cancers and there is a positive correlation between COX-2 and ANGPTL4 as well STAT1 expression in the specimens tested. These results indicate that PGE2 plays an important role in promoting cancer cellular adaptive response to hypoxia and cancer progression via ANGPTL4. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 399. doi:10.1158/1538-7445.AM2011-399
Aspergillus fumigatus in sputum during acute EBV infection
Authors: M. L SCHMID, S. T GREEN;, T MURAYAMA
Journal: Thorax (1999)

Venous aneurysm of the azygos arch is a very rare cause of mediastinal mass and is usually an incidental finding on chest radiography.Nowadays the diagnosis is made by non-invasive tests such as thoracic CT scanning and/or magnetic resonance imaging.The case is described of an asymptomatic woman in whom a mediastinal mass due to an azygos vein aneurysm was diagnosed by non-invasive procedures, the aetiology of which, in all probability, was idiopathic.
Altered Autonomic Support of Arterial Blood Pressure With Age in Healthy Men
Authors: Pamela Parker Jones, Linda F. Shapiro, Gretchen A. Keisling, Jens Jordan, John R. Shannon, Robert A. Quaife, Douglas R. Seals
Journal: Circulation (2001)

Background Primary aging is associated with changes in the autonomic nervous system (ANS), but the functional significance of these changes for systemic circulatory control of arterial blood pressure (BP) is unknown. We tested the hypothesis that ANS support of BP is altered in healthy older humans. Methods and Results A total of 23 young (aged 24±1 years; systolic/diastolic BP, 126±2/66±1 mm Hg) and 16 older (aged 65±1 years; systolic/diastolic BP, 125±3/62±2 mm Hg) healthy men were studied before and during ganglionic blockade (intravenous trimethaphan). The reduction in mean BP (radial artery catheter) with trimethaphan was almost twice as great in the older men (−33±2 versus −19±2 mm Hg; −40% versus −22% of baseline; P &lt;0.01) due to a lack of increase in heart rate (3±2 versus 25±2 bpm; P &lt;0.001) and cardiac output (−0.42±0.19 versus 1.01±0.26 L/min; P &lt;0.001); the decreases in systemic vascular resistance were not different. The absence of tachycardia in the older men was associated with reduced baseline heart rate variability (HRV, P &lt;0.05); the change in heart rate with trimethaphan correlated with the standard deviation of the R-R intervals (HRV SD R-R interval ; r =0.57, P &lt;0.001). Among individual subjects (pooled groups), the reductions in mean BP with trimethaphan were most strongly related to measures of sympathetic activity ( r =0.58 to 0.67, P &lt;0.005), change in mean BP with intravenous phenylephrine ( r =0.57, P &lt;0.001), and HRV SD R-R interval ( r =−0.40, P &lt;0.01). Conclusions ANS support of BP is altered with age in healthy men due to less cardiac vagal inhibition of heart rate and cardiac output. Basal sympathetic activity and α-adrenergic vascular sensitivity are also key physiological correlates of ANS support of BP in healthy men.
Measuring Free Radicals
Authors: Rebecca Voelker
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Promoter hypermethylation and global hypomethylation are independent epigenetic events in lymphoid leukemogenesis with opposing effects on clinical outcome
Authors: J Roman-Gomez, A Jimenez-Velasco, X Agirre, J A Castillejo, G Navarro, L Garate, E San Jose-Eneriz, L Cordeu, M Barrios, F Prosper, A Heiniger, A Torres
Journal: Leukemia (2006)
Effect of Adding Systematic Family History Enquiry to Cardiovascular Disease Risk Assessment in Primary Care
Authors: Nadeem Qureshi
Journal: Annals of Internal Medicine (2012)

Background: Evidence of the value of systematically collecting family history in primary care is limited. Objective: To evaluate the feasibility of systematically collecting family history of coronary heart disease in primary care and the effect of incorporating these data into cardiovascular risk assessment. Design: Pragmatic, matched-pair, cluster randomized, controlled trial. (International Standardized Randomized Controlled Trial Number Register: ISRCTN 17943542). Setting: 24 family practices in the United Kingdom. Participants: 748 persons aged 30 to 65 years with no previously diagnosed cardiovascular risk, seen between July 2007 and March 2009. Intervention: Participants in control practices had the usual Framingham-based cardiovascular risk assessment with and without use of existing family history information in their medical records. Participants in intervention practices also completed a questionnaire to systematically collect their family history. All participants were informed of their risk status. Participants with high cardiovascular risk were invited for a consultation. Measurements: The primary outcome was the proportion of participants with high cardiovascular risk (10-year risk ≥20%). Other measures included questionnaire completion rate and anxiety score. Results: 98% of participants completed the family history questionnaire. The mean increase in proportion of participants classified as having high cardiovascular risk was 4.8 percentage points in the intervention practices, compared with 0.3 percentage point in control practices when family history from patient records was incorporated. The 4.5–percentage point difference between groups (95% CI, 1.7 to 7.2 percentage points) remained significant after adjustment for participant and practice characteristics (P = 0.007). Anxiety scores were similar between groups. Limitations: Relatively few participants were from ethnic minority or less-educated groups. The potential to explore behavioral change and clinical outcomes was limited. Many data were missing for anxiety scores. Conclusion: Systematically collecting family history increases the proportion of persons identified as having high cardiovascular risk for further targeted prevention and seems to have little or no effect on anxiety. Primary Funding Source: Genetics Health Services Research program of the United Kingdom Department of Health.
Neutropenia in three patients with rheumatic disorders. Suppression of granulopoiesis by control-sensitive thymus-dependent lymphocytes.
Authors: G C Bagby, J D Gabourel
Journal: Journal of Clinical Investigation (1979)

A man with polymyalgia rheumatica (patient 1) and two patients (2 and 3) with Felty's syndrome had neutropenia at the time of diagnosis. Bone marrow samples in each patient were cellular but showed an "arrest" of granulocyte maturation at the myelocyte stage. Agar colony growth of marrow cells from each patient was subnormal but increased after removal of sheep erythrocytes rosette-forming cells (thymus-dependent [T] cells) from marrow cell suspensions before culture. Preincubation of marrow cells with cortisol also enhanced colony growth. Maximum enhancement with cortisol occurred at 1 mM (patient 1), 1 microM (patient 2), and 10 nM (patient 3). Cortisol failed to enhance colony growth after removal of T cells from marrow cell suspensions. Peripheral blood lymphocytes (PBL) and PBL-conditioned medium from all three patients inhibited colony growth of normal human marrow cells. Cortisol treatment of PBL or T depletion from PBL abrogated the inhibition in coculture and with conditioned medium. Prednisone therapy resulted in the disappearance of suppressor T-cell function concomitant with hematologic improvement in patients 2 and 3, but suppressor T cells persisted in patient 1, who did not respond to prednisone. We conclude that cortisol-sensitive T lymphocytes inhibited granulopoiesis in vitro probably by elaboration of a soluble factor or factors. Our results suggest (a) that neutropenia in these patients resulted, at least in part, from T-cell suppression of granulopoiesis, (b) that the effectiveness of prednisone therapy was a result of its inhibition of suppressor T cells, and (c) that responses to glucocorticoid therapy may be predicted in such patients with the agar culture technique and cortisol dose response in vitro.
Role of transforming growth factor ? type II receptor in hepatic fibrosis: Studies of human chronic hepatitis C and experimental fibrosis in rats
Authors: Dominique Roulot, Ann-Marie Sevcsik, Thierry Coste, Donny A. Strosberg, Stefano Marullo
Journal: Hepatology (1999)

Transforming growth factor β (TGF–β) is an antiproliferative and profibrogenic cytokine that signals through a receptor consisting of type I and type II (TβRII) components. We have examined changes in the expression of TβRII during liver injury, correlating this with the antiproliferative and profibrogenic effects of TGF–β 1 . The experimental material consisted of biopsy samples of liver from patients with chronic hepatitis C and rats in which liver injury was induced by ligation of the common bile duct. Stellate cells were isolated from normal or injured rat liver and studied as fresh isolates. In the biopsy samples from patients, mRNAs for TGF–β 1 and TβRII were measured using competitive reverse polymerase chain reaction (PCR). TGF–β 1 mRNA was significantly increased in chronic hepatitis C relative to healthy controls ( P = .03), while TβRII mRNA was significantly decreased ( P = .001). In the rat model, 5 days after bile duct ligation during increased TGF–β expression, mRNA for TβRII in stellate cells was 40% of that in stellate cells from control livers. This coincided with increased expression of collagen I mRNA and proliferation of stellate cells. The reciprocal relationship between expression of TGF–β and the type II receptor suggest ligand–mediated receptor down–regulation. The decreased level of TβRII appears to be permissive for proliferation while supporting ongoing fibrogenesis. We conclude that modulation of this receptor may be critical to the progression of wound repair in liver.
Reports on ECHO-28 Virus-Reply
Authors: Maurice A. Mufson, Robert M. Chanock
Journal: JAMA (1964)

In reply to Dr. Sartwell's comments concerning our report on the "affect of Neutralizing Antibody on Experimental Rhinovirus Infection" and the accompanying editorial, we would like to point out that Pelon, Mogabgab, and associates did in fact publish the first report on the isolation of ECHO-28 virus (designated GL-2060) and that publication of this report<sup>1</sup>preceded that of the initial report by Price by at least six months. On this basis, it would seem clear that Pelon, Mogabgab, and associates described the first virus belonging to the group now designated "rhinoviruses," and therefore the statement in the editorial is not inaccurate. After presenting their report in<i>Bacteriological Proceedings</i>, Pelon, Mogabgab, and co-workers published a more detailed account of their studies on ECHO-28 virus in the<i>Proceedings of the Society for Experimental Biology and Medicine</i>(<b>94</b>:262 [Feb] 1957).
Acute renal failure in patients over 80 years old: 25-years' experience
Authors: K. Akposso, A. Hertig, R. Couprie, A. Flahaut, C. Alberti, G. -A. Karras, J. -P. Haymann, M.-A. Costa De Beauregard, A. Lahlou, E. Rondeau, J. -D. Sraer
Journal: Intensive Care Medicine (2000)
TCT-624 Impact of Post Dilation on the Acute and One-Year Clinical Outcomes of a Large Cohort of Patients Treated Solely With the Absorb Bioresorbable Vascular Scaffold
Authors: Jose d Costa, Alexandre Abizaid, Antonio L. Bartorelli, Robert J. Van Geuns, Bernard Chevalier, Marco A. Perin, Rodolfo Staico, Roberto Botelho, Ashok Seth, Patrick W. Serruys
Journal: Journal of the American College of Cardiology (2014)
Poor-Law Medical Relief
Authors: R. Faircloth
Journal: BMJ (1844)

others, in respect of salary, I had not, as is now proved, a chance of their being accepted; and why ?A few weeks before the expiration of the year the ass:stant-commissioner visited the union, when he inquired of the guardians if there was any complaint against the medical officers; to which there was a reply in the negative." Oh !" says he, " then they must be re-elected."" But what will Mr.say, for we have not acted quite the thing towards him ?" was the immediate question." Oh! never mind him; he lost it in the lucky year," was Mr. Com.missioner's rejoinder.Such, then, is a part of the " tender system," as appertains to the conduct of guardians, assistant-com.missioners, and of one medical man towards another.Now, however, the office is made permanent alto.gether, and I have no further interest in the matter.
Hospital Care in New York City. The Roles of Voluntary and Municipal Hospitals.
Authors: Roger G. Olin
Journal: JAMA (1963)

This book, a valuable reference work for students of hospital planning, covers hospital programs, personnel, facilities, organization, and finances in New York City. It compares the operation of the voluntary and municipal hospital systems, and presents alternative proposals for bringing about a greater degree of cooperation between the two as well as cooperation among the various hospitals in each system.  One of the problems discussed is the duplication of expensive hospital facilities that are in limited demand, such as cobalt bombs for cancer therapy. While regional hospital planning would intend that certain programs of care be located in some hospitals and be excluded from others, the book recognizes that difficulties will be involved. The staff of a hospital giving up a program would stand to lose income from the care of private patients. The book suggests that selective granting of duplicate staff appointments to certain physicians, namely, those with special
Effects of calcipotriol on stratum corneum barrier function, hydration and cell renewal in humans
Authors: I. EFFENDY, C. KWANGSUKSTITH, M. CHIAPPE, H.I. MAIBACH
Journal: British Journal of Dermatology (1996)

Calcipotriol. a vitamin D analogue utilized for psoriasis, has irritation as its most frequent reported adverse event. However, studies on its irritant properties in humans have produced conflicting data. This study evaluates the effect of calcipotriol on stratum corneum barrier function, hydration and cell turnover in healthy volunteers, compared with sodium lauryl sulphate (SLS) as a model irritant. Calcipotriol 0·005% ointment and 1% aqueous SLS solution were applied for 2 weeks (5 consecutive days weekly) on untreated and on dansyl‐chloride‐labelled skin. Irritant responses were documented by visual scoring and by measurement of the transepidermal water loss (TEWL) and stratum corneum hydration (electrical capacitance), until day 18 Stratum corneum turnover time (SCTT) was the time in days between staining (day 0) and the disappearance of dansyl fluorescence. SLS caused more erythema, scaling, and a significant TEWL increase for 18 days. In contrast, calcipotriol induced erythema, and slightly but significantly increased TEWL on day 11 only, as compared with the vehicle control (P<0·05) SLS, but not calcipotriol, caused skin dryness from day 4 to day 18. The shortest SCTT was obtained at SLS‐exposed sites (11·2 ± 0·7 days: mean± SD). Calcipotriol significantly shortened SCTT (16.3 ± 1.1 days) when compared with its vehicle. Compared with the skin irritation induced by SLS, under these test conditions, calcipotriol is a far weaker irritant on normal human skin. In addition, calcipotriol accelerates stratum corneum turnover to a significantly greater extent than its vehicle.
PRIMARY CARCINOMA OF THE LUNG IN A TWENTY-THREE YEAR OLD MAN
Authors: L. A. Crowell
Journal: JAMA (1934)

Since primary carcinoma of the lung is rare in the twenties, I thought it would be of interest to present this case: H. D. R., a man, aged 23, a textile foreman, admitted to the Lincoln Hospital, July 14, 1933, suffered chiefly from cough, dyspnea, pain in the right side of the chest and weakness. The illness began May 26, seven weeks before admission, with the sudden development of a cough with expectoration of brown sputum. The family stated that he had seemed more irritable and out of sorts since February 1933 and had lost weight during that time, although he had had no definite localizing symptoms. The cough got steadily worse until two weeks before admission, when the patient, while at work, suddenly had a severe lancinating pain in the middle of the right chest, made worse by inspiration and by the beating of the heart. He immediately sought
Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress
Authors: Katrin F. Chua, Raul Mostoslavsky, David B. Lombard, Wendy W. Pang, Shin’ichi Saito, Sonia Franco, Dhruv Kaushal, Hwei-Ling Cheng, Miriam R. Fischer, Nicole Stokes, Michael M. Murphy, Ettore Appella, Frederick W. Alt
Journal: Cell Metabolism (2005)
Assessment of myocardial contractility from ventricular pressure recordings
Authors: N. S. Nejad, M. D. Klein, I. Mirsky, B. Lown
Journal: Cardiovascular Research (1971)

Peak values of the normalized first and second derivatives of left ventricular pressure, which are measured during the isovolumic contraction period, have been shown to be useful measures for assessing myocardial contractility. These indices were readily obtained from high speed pressure tracings by means of a fiberoptic pressure catheter which has an unusually high frequency response and low noise level.
Narrative Review: Reperfusion Strategies for ST-Segment Elevation Myocardial Infarction
Authors: Henry H. Ting, Eric H. Yang, Charanjit S. Rihal
Journal: Annals of Internal Medicine (2006)

Optimal treatment for ST-segment elevation myocardial infarction depends on early diagnosis and rapid selection of the appropriate reperfusion strategy. Primary percutaneous coronary intervention (PCI) is the preferred reperfusion strategy at PCI-capable hospitals. For hospitals without PCI capability, there are 2 reperfusion strategies, primary PCI and thrombolytic therapy, which are both supported by clinical evidence and national guidelines. Transferring patients for primary PCI may cause delays and requires established, proven protocols, systems, and networks to achieve minimal door-to-balloon times. The authors review the available data and present a systematic, evidence-based approach in a simple framework to enable noncardiovascular and cardiovascular physicians to select the optimal reperfusion strategy. The framework is based on available data from clinical trials and local circumstances from clinical practice by incorporating duration of symptoms (fixed ischemia time) and anticipated transport delays to a PCI-capable facility (incurred ischemia time).
Role of liver biopsy (LB) in patients with human immunodeficiehcy virus (HIV) infection
Authors: X Bertrán, R Plans, JL Mate, G Sirera, F Fdez-Bañares, E Cabré, I Ojanguren, R Morillas, E Doménech, JL Guer, MA Gusull
Journal: Journal of Hepatology (1991)
Breast cancer: asking patients what they want
Authors: C. Williamson
Journal: BMJ (1996)

Makes for better decisions about treatment and research, and better outcomes

Amid the uncertainties surrounding the treatment of breast cancer, there can be important mismatches between what clinicians and local health services provide and what some women would have wanted. There are also concerns about the way research is conducted and how women come to take part in it.1 Both in treatment and research, women sometimes conclude that they and their interests meet with scant respect.2 So research that picks up trends in patients' views and detects new issues as professional practices or patients' expectations change is a necessary complement to professional assumptions and aspirations.

Fortunately, there is an exemplary study, rich in findings and insight, of women's views about decision making in treatment and research and about their reasons for holding them. Alderson and her colleagues compared the views of healthy women who had undergone screening, women who had been treated for breast cancer, and health professionals over a range of contentious issues.3 For treatment, most women in both categories of patient thought that all options should be discussed with them, including the treatments' long term implications, benefits, and risks. Most …
THE DIURNAL MITOTIC RHYTHM IN THE HUMAN EPIDERMIS
Authors: L. B. FISHER
Journal: British Journal of Dermatology (1968)

Journal Article THE DIURNAL MITOTIC RHYTHM IN THE HUMAN EPIDERMIS Get access L. B. FISHER L. B. FISHER Institute of Dermatology, London, England Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 80, Issue 2, 1 February 1968, Pages 75–80, https://doi.org/10.1111/j.1365-2133.1968.tb12263.x Published: 01 February 1968 Article history Accepted: 22 August 1967 Published: 01 February 1968