tbuckley/cabot-search huggingface dataset:
Plexiform neurofibromatosis of the liver and mesentery in a child
Authors: Jacqueline S. Partin, Bernard P. Lane, John C. Partin, Lawrence R. Edelstein, Cedric J. Priebe
Journal: Hepatology (1990)

Plexiform neurofibromatosis of the liver was recognized by needle biopsy of the liver in an 11-yr-old boy who had a 2-yr history of diarrhea, intermittent abdominal pain, failure to gain weight and progressive abdominal distention. Imaging studies demonstrated a large retroperitoneal mass; a laparotomy was performed. At surgery, the mesentery was greatly thickened by neurofibromas, and plexiform neurofibroma extended through the hilum of the liver. Light and electron microscopy demonstrated that in addition to the direct involvement by tumor, neural hyperplasia existed throughout the liver. The most distal ramifications of the portal spaces were filled with Schwann cells, bundles of unmyelinated nerves and perineurium-surrounded nerves containing myelinated and unmyelinated fibers. The ultrastructural findings were consistent with stimulation of proliferation of all the portal neural elements and tumoral tissue. The nontumoral response was more than simple hyperplasia because it appeared to result in fibrotic changes in the most involved areas and active breaching of the limiting plate with destruction of hepatocytes and collagen deposition throughout the liver. (Hepatology 1990;12:559-564).
New Prognostic Score Based on Treatment Outcome of Patients With Relapsed Hodgkin's Lymphoma Registered in the Database of the German Hodgkin's Lymphoma Study Group
Authors: A. Josting
Journal: Journal of Clinical Oncology (2002)

PURPOSE: To evaluate salvage treatment outcome of patients with relapsed Hodgkin’s disease (HD) and to distinguish different risk groups using identified prognostic factors. PATIENTS AND METHODS: From 4,754 patients registered in the German Hodgkin’s Lymphoma Study Group (GHSG) database between 1988 and 1999, 422 patients with early (n = 170) or late (n = 252) relapsed HD were identified. One hundred seven patients (25%) relapsed after radiotherapy (RT) for early stages, 133 patients (32%) after combined-modality therapy for intermediate stages, and 182 patients (43%) after chemotherapy (CT) and RT to initial bulky disease or residual lymphoma for advanced stages. At relapse, characteristics of these 422 patients (median age, 38 years; range, 17 to 77) were stage III/IV, 45%; B symptoms, 24%; elevated erythrocyte sedimentation rate, 29%; anemia, 13%; and Karnofsky performance score, less than 90 in 13%. At first relapse, salvage treatment was RT in 13%, CT in 54%, and high-dose chemotherapy (HDCT) with au...
Reversible Paraplegia and Acute Renal Failure Due to Occlusive Disease of the Abdominal Aorta
Authors: DANIEL J. POTTER
Journal: Annals of Internal Medicine (1968)

Reversible paraplegia and acute renal failure occurred in two patients. One case was due to atheromatous occlusion of the left common iliac with thrombosis and propagation of the thrombus up the aorta, and the other a result of extensive traumatic dissecting aneurysm in a healthy young man. After operative intervention and hemodialysis, there was complete reversal of renal failure in both cases. Complete reversal of paraplegia occurred in one case, and there was residual paraplegia in the other. The combination of paraplegia and unexplained oliguria should lead to aortography, even if spinal cord trauma is suspected. If occlusive disease is revealed, prompt operative correction is mandatory to prevent irreversible paraplegia and renal failure.
Estimating plasma antidiuretic hormone levels.
Authors: K. K. Gupta
Journal: BMJ (1968)

predisposed subject in response to trauma of the skin.It grows outwards to a very large size in time and may become pedunculated.Hypertrophic scars in contrast are seldom of uniform consistency unless very small, may have hypovascular areas, may contract in parts, and do not form large lumps.It is these that may be provoked by -wrongly placed incisions or infection or skin loss as described by your leader writer.In general they are more amenable to surgery and radiotherapy.-Iam, etc.,
E-cadherin is involved in the intrahepatic metastasis of hepatocellular carcinoma
Authors: T Osada
Journal: Hepatology (1996)

In human hepatocellular carcinoma (HCC), the liver is the major target organ of metastasis, which is known as intrahepatic metastasis. To analyze the mechanism of this metastasis, we established two sublines from the human HCC cell line Li7. Subline Li7HM produced multiple liver metastasis, whereas subline Li7NM never did so after intrasplenic injection into nude mice. Two-dimensional gel electrophoresis and immunoblot analysis showed that only Li7NM expressed vimentin and lacked E-cadherin expression, indicating that this clone had undergone epithelial-mesenchymal transition. We then transfected mouse E-cadherin complementary DNA into Li7NM cells and found that the transfectant cells (EM16.21B.3) formed liver metastasis (8/16 mice) after intrasplenic injection and liver tumors (11/13 mice) after intrahepatic injection, whereas the control cell line formed no tumors. These results suggest that E-cadherin plays an important role in the process of intrahepatic metastasis of HCC.
An Uncommon Case of Septic Cortical Osteitis
Authors: Christian Picard, Bruno Krug, Yves Boutsen, Bénédicte Delaere, Jean-François Nisolle, Pierre Abouhamad, Anne-Sophie Pirson, Thierry Vander Borght
Journal: Clinical Nuclear Medicine (2007)

A 39-year-old healthy female patient with an unremarkable medical history complained about a rapidly progressive pain for a period of 1 month at the level of the anterior part of the right leg that was not relieved by NSAIDs. She mentioned only that she resumed her high level sport training 6 months before the onset of the symptoms. There was no specific history of trauma, fever, or other distinctive symptoms. On clinical examination, the right pretibial skin was inflamed and extremely painful. Walking became difficult the last 2 weeks. No skin injury was observed on the right leg and foot. The early blood tests, consistent with moderate aspecific inflammation, showed a slightly elevated C-reactive protein and sedimentation rate, without any leukocytosis. Upon first consultation the plain radiographs of the right leg were normal, but control radiographs obtained 2 weeks later showed cortical and lamellar lucencies of the right tibial crest.
252 COMPARATIVE GENOMICS ON GENE EXPRESSION OF P53 FAMILY TARGET GENES REVEALS 28 GENES SIGNIFICANTLY ASSOCIATED WITH SURVIVAL IN PATIENTS WITH HCC
Authors: F. Staib, A.F. Koch, A. Pelc, H.M. Mundt, M. Krupp, P.R. Galle, W. Stremmel, A. Teufel, M. Müller
Journal: Journal of Hepatology (2011)
Auditing absence due to sickness
Authors: S Khan, T C Aw
Journal: BMJ (1995)

EDITOR,—Martin McKee and colleagues highlight some difficulties with the use of routine data for audit and refer to experience in obstetrics.1 In occupational health practice we have encountered similar problems in setting up a system to audit absence attributed to sickness. Certificates for absences due to sickness of more than seven days are obtained by employees from general practitioners and usually forwarded to the employer's personnel or finance department. For self certified spells of illness of shorter …
Abstract 2730: Role of Stat1 in skin tumor promotion
Authors: Ronald Bozeman, John DiGiovanni, Erika Abel
Journal: Cancer Research (2011)

Abstract Inflammation is a key component of cancer development in many tissues. Emerging clinical observations support the idea of a strong association of chronic inflammation and cancer. The JAK-STAT pathway is one of the major signaling pathways involved in modulating both pro- and anti-inflammatory responses. Aberrant expression of STATs has been reported in multiple human cancers and in animal models of tumorigenesis. Previous work performed in our lab demonstrated a role for Stat1 in mediating the promotion stage of epithelial multi-stage carcinogenesis in mouse skin when chrysarobin was used as the promoting agent. To further investigate the role of Stat1 in chrysarobin-mediated skin tumor promotion, Stat1 knockout (KO) mice and wild-type controls were treated with chrysarobin and the inflammatory response was assessed. Stat1 deficiency caused a reduction in the dermal inflammatory response following a single topical application of chrysarobin. In this regard, Stat1 KO mice had reduced dermal immune cell influx following chrysarobin treatment. In particular, Stat1 KO mice exhibited reduced influx of macrophages following a single application. Other results also suggest that Stat1 may regulate various cytokine/chemokines involved in the inflammatory response following chrysarobin treatment. Mice deficient in Stat1 displayed an attenuated induction of Cox-2 mRNA and protein compared to wild-type controls following a single application of chrysarobin (200 nmol per mouse). This latter data suggest that Stat1 may be involved in the regulation of Cox-2 in keratinocytes. Collectively, these findings suggest that Stat1 may contribute to chrysarobin-mediated skin tumor promotion by regulating, in part, levels of Cox-2, PGE2 and ultimately skin inflammation. These and other ongoing studies aimed at identifying the mechanistic basis for the role of Stat1 in chrysarobin-mediated tumor promotion will be presented. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2730. doi:10.1158/1538-7445.AM2011-2730
Programmed electrical stimulation in patients with high-grade ventricular ectopy: electrophysiologic findings and prognosis for survival.
Authors: J A Gomes, R I Hariman, P S Kang, N El-Sherif, I Chowdhry, J Lyons
Journal: Circulation (1984)

The significance and treatment of ventricular premature beats (VPBs) in patients without sustained ventricular tachycardia (VT), sudden death, or syncope remains unclear. We undertook a prospective study of programmed electrical stimulation (up to two extrastimuli and burst pacing) in 73 patients (age 60 +/- 10 years) with high-grade VPBs who had no evidence of sustained VT, sudden death, or syncope as determined by 48 hr of monitoring in the cardiac care unit and 48 hr Holter monitoring. Fifty-six patients (76.7%) had atherosclerotic heart disease, 10 (13.7%) had cardiomyopathy or valvular heart disease, and seven (9.6%) had no evident heart disease. Thirty-seven patients (50.7%) had Lown grade IVB VPBs, 30 (41.1%) had Lown grade IVA VPBs, and six (8.2%) had Lown grade III VPBs. Programmed electrical stimulation identified two groups of subjects: group 1 comprised 20 patients (27%) in whom VT or ventricular fibrillation was induced, group 2 comprised 53 patients (73%) in whom no ventricular arrhythmia or only two to four repetitive ventricular responses were induced. There was a significant difference between the presence of atherosclerotic heart disease, old myocardial infarction, and ejection fraction of less than 40% in group 1 compared with group 2. However, there was no significant difference in the grade of VPBs between the two groups. Seventeen of 20 patients from group 1 were placed on antiarrhythmic therapy (defined by programmed electrical stimulation), whereas group 2 patients were randomly assigned to prophylactic antiarrhythmic therapy. A total of 70 patients were followed up for 30 +/- 15 months. The incidence of sustained VT and/or sudden death (31.5% vs 2%; p less than .001) was significantly higher in group 1 compared with group 2.(ABSTRACT TRUNCATED AT 250 WORDS)
P245 Evaluation Of Outcomes Of Oral Ribavirin In The Treatment Of Viral Lower Respiratory Tract Infection In Lung Transplant Patients
Authors: R. Hackett, S. Isse, J. Parmar, D. Thomas
Journal: Thorax (2014)

<h3>Introduction</h3> Viral lower respiratory tract infections are common in lung transplant patients and contribute to the development of chronic rejection. Studies have highlighted the improvement in lung function and reduction in relative risk of chronic rejection in patients who are treated with appropriate anti-virals. Our study aimed to investigate the efficacy of three different routes of administration in patients with symptomatic declines in lung function and positive viral cultures. <h3>Method</h3> Retrospective cohort study of viral respiratory tract infections treated with Ribavirin over a 5 year period was performed. Patients were divided in to 3 groups dependent on route of administration – Oral, Nebulised or Intravenous. Data was collected on patient demographics along with the indication for transplant, time since transplantation, pre and post treatment (6–8 weeks) lung function, viral cultures and details of any confounding factors such as prior rejection or concomitant bacterial infection were recorded. <h3>Results</h3> 47 patients were identified. 12 patients were excluded due to insufficient clinical data. Of the remaining 34 patients, 11 were treated with Oral medication, 13 with Nebulised and 10 with Intravenous. <h3>Conclusion</h3> Treatment with Ribavirin results in an improvement in lung function. In this small study it appears that there is no difference in lung function between the different routes of administration. Whilst the efficacy appears comparable oral treatment offers significant advantage to the patients and has benefits for treatment cost and bed occupancy.
Indices of inflammatory activity. Relationship between isotope studies and clinical methods.
Authors: W C Dick, M F Grayson, A Woodburn, G Nuki, W W Buchanan
Journal: Annals of the Rheumatic Diseases (1970)

Rheumatoid arthritis is still an incurable disease and its management must include the use of non- specific suppressive agents.The great majority of pharmacological agents in this class are drugs of relatively small effect.The difficulty of assessing any such drug is compounded by the spontaneous alterations in activity which are a feature of this disease.There is no difficulty in detecting major changes in disease activity clinically.However, although many methods of assessment have been studied, no single method has proved entirely satisfactory for the detection of small changes in inflammatory activity, and it is still common practice to employ several methods concurrently (Hollander, Stoner, Brown, and deMoor,
Abstract 257: PARP inhibitor induces cytotoxicity in primary lung cancer through caspase induction
Authors: Nupur N. Gangopadhyay, James D. Luketich, Amy Opest, Rodney Landreneau, Matthew J. Schuchert
Journal: Cancer Research (2012)

Abstract Considering the fact that lung cancer has a high incidental rate among all cancer types, our investigation was aimed to see if PJ34, a PARP inhibitor, could independently exert cytotoxicity in primary lung cancer cells. In the past this PARP inhibitor has been used in combination with other DNA targeted chemotherapeutics or in patients with DNA repair defects (e.g. BRCA mutation), however, based on our published findings we hypothesize that PJ34 can target lung cancer using alternative mechanisms where defects in DNA repair or synthetic lethality are not required. Additionally, we wanted to reveal the specific mechanisms of PARP inhibitor mediated cytotoxicity in lung cancer cells. Anti-cancerous effects of PJ34 were evaluated on six non-small cell lung cancer cell lines developed from surgically resected tissue. Using WST-1 dye and BrdU assay, 30uM (ED50) of PJ34 treatment showed a variable amount of cell survival and DNA synthesis among cultures used herein. Cellular morphological changes in response to the PJ34 treatment were investigated using annexin-V expression, nuclear fragmentation staining, and PARP specific protein in Western blot. Mitochondrial membrane potential changes were measured through JC-1 dye staining and indicated increased stress upon PJ34 treatment. The abundance of Caspase-9 further proves the role of mitochondrial stress in PJ34 treated cells. Immunofluorescent staining for Caspase-3 clearly showed changes towards apoptosis under PJ34 treated vs. untreated conditions. Additionally, a Caspase-3 specific protein band in PJ34 treated cells indicates the possibility of apoptosis through a caspase dependent pathway. Furthermore, lower expressions of PAR in PJ34 treated cells were indicative of PARP inhibition. This study has brought a new paradigm for using PJ34 as a potential therapeutic against lung cancer because of its ability to work regardless of a patient's genetic makeup as well as the possibility of using this group of compounds as independent chemotherapeutic agents. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 257. doi:1538-7445.AM2012-257
Predominant functional roles for thromboxane A2 and prostaglandin E2 during late nephrotoxic serum glomerulonephritis in the rat.
Authors: K Takahashi, G F Schreiner, K Yamashita, B W Christman, I Blair, K F Badr
Journal: Journal of Clinical Investigation (1990)

While much is known regarding acute nephrotoxic serum (NTS)-induced glomerular injury, the glomerular dynamics and pathophysiologic mediators of the more relevant chronic autologous phase remain poorly defined. Studies were performed in rats 14 d after injection of rabbit serum (n = 6), NTS in the absence (n = 6), or presence, of a cyclooxygenase inhibitor, ibuprofen (n = 6) or a thromboxane A2 (TxA2) receptor antagonist, L-670,596 (n = 5). A mesangial macrophage/monocyte infiltrate was noted with equal intensity in all NTS-treated rats. Glomerular generation rates of prostaglandin (PG) E2, PGF2a, and TxA2 in nephritic kidneys were dramatically increased as compared to controls. 2 wk after NTS, there was an increase in glomerular plasma flow rate (SNPF), attainment of filtration pressure disequilibrium, and augmentation of net transcapillary hydraulic pressure difference (delta P). Glomerular filtration rate (GFR), however, was reduced, due to a marked fall in the glomerular capillary ultrafiltration coefficient (Kf). Cyclooxygenase inhibition resulted in normalization of glomerular eicosanoid generation rates, amelioration of proteinuria, afferent vasoconstriction, and normalization of SNPF, delta P, Kf, and GFR. Selective antagonism of TxA2 also led to preservation of Kf, but was without effect on SNPF, thereby leading to elevated values for GFR. Thus, in contrast to the pathophysiologic role of arachidonate-lipoxygenase products in the early heterologous phase, PG-mediated vasodilatation and TxA2-induced reductions in Kf and GFR underlie glomerular functional changes during autologous mesangioproliferative glomerulonephritis.
<i>CCR</i> 20th Anniversary Commentary: BMS-247550—Microtubule Stabilization as Successful Targeted Therapy
Authors: Navjotsingh Pabla, Alex Sparreboom
Journal: Clinical Cancer Research (2015)

Abstract In a landmark article published in the May 1, 2001, issue of Clinical Cancer Research, Lee and colleagues reported the original preclinical studies demonstrating anticancer activity of BMS-247550 (ixabepilone) against taxane-sensitive and taxane-resistant cancers. Subsequent clinical trials established the clinical efficacy of ixabepilone, leading to its regulatory approval for the treatment of drug-resistant metastatic or locally advanced breast cancers. Clin Cancer Res; 21(6); 1237–9. ©2015 AACR. See related article by Lee et al., Clin Cancer Res 2001;7(5) May 2001;1429–37
Abstract IA21: Changing chasses and inventing elements: Developing a combined systems biology and engineering approach to designing complex function in cells
Authors: Adam P. Arkin
Journal: Cancer Research (2012)

Abstract To meet the goal of creating reliable, predictable, efficient, and transparent methods to harness cellular capabilities for human benefit, it is necessary both to have standard libraries of elements from which useful pathways can be constructed and an understanding of the how host physiology and the environment impacts the functioning of these heterologous circuits. We show how variations in cellular and environmental context affect the operation of the basic central dogma functions underlying gene expression. Then we describe progress on creating a complete, scalable, and relatively homogeneous and designable sets of part families that can control central dogma function predictably in the face of varying configurations, genetic contexts, and environments. We show the challenges that arise in attempting this in applications such as a tumor destroying bacteria. Citation Format: Adam P. Arkin. Changing chasses and inventing elements: Developing a combined systems biology and engineering approach to designing complex function in cells [abstract]. In: Proceedings of the AACR Special Conference on Chemical Systems Biology: Assembling and Interrogating Computational Models of the Cancer Cell by Chemical Perturbations; 2012 Jun 27-30; Boston, MA. Philadelphia (PA): AACR; Cancer Res 2012;72(13 Suppl):Abstract nr IA21.
1102. Genetically Engineered Bifidobacterium animalis Expressing Salmonella flagellin Gene for the Mucosal Immunization in Mouse Model
Authors: Toshiro Shirakawa, Tetsuo Takata, Akinobu Gotoh, Yasunobu Kano, Masato Kawabata
Journal: Molecular Therapy (2006)

Background; It is critical for the host's defense against enteric infections to elicit an immunological response in mucosal membrane where is a major starting point of infectious disease including typhoid fever. In the present study, we have developed the recombinant Bifidobacterium animalis genetically modified with Salmonella flagellin gene for mucosal immunization as an oral typhoid vaccine. Methods; We constructed the oral vaccine against Salmonella typhimurium, consisting of the recombinant Bifidobacterium animalis (B. animalis) containing flagellin gene of Salmonella. The recombinant B. animalis was administered orally to mouse for 6 weeks. Anti-flagellin antibodies in serum and stool were measured by enzyme-linked immunosorbent assay (ELISA). Result; The significantly higher level of the flagellin-specific IgA was detected in serum and stool of the mice administrated with the recombinant B. animalis containing flagellin gene than that of the mice administrated with the parental B. animalis.Conclusion;These results suggested the potency of the oral vaccination against Salmonella infections using the recombinant B. animalis genetically modified with flagellin gene of Salmonella.
EXPERIENCES WITH MARSILID WITH REPORT OF ONE DEATH
Authors: ERWIN R. SMARR, HERMAN WOLF, MAURIE D. PRESSMAN
Journal: American Journal of Psychiatry (1958)

Marsilid has proven to our satisfaction that it is the most effective chemical to appear so far for the treatment of ambulatory depressions. Its action is physiological. We do not know its effectiveness for patients severely depressed enough to require hospitalization. Several of our patients did not require ECT, which we would otherwise have prescribed. The drug is apparently toxic to a dangerous degree to certain individuals, and toxic to very mild degrees in others. Perhaps it is a safe drug to use for a limited period. It is unclear whether total dosage, duration of treatment, or purely idiosyncracity are related to these hepatitis reactions. This is an important therapeutic advance which should be pursued further, but a safe regimen needs to be worked out as more data are accumulated.
1028-64 Functional Significance of Hystopathological Evidence of Microvascular Abnormalities in Syndrome X and Other Myocardial Diseases
Authors: Alfredo Marchese, Adele Chiddo, Sergio Musei, Nino Camassa, Alessandro Bartone, Antonio Gaglione, Gilda Caruso, Paolo Rizzon
Journal: Journal of the American College of Cardiology (1995)
Sustained correction of B-cell development and function in a murine model of X-linked agammaglobulinemia (XLA) using retroviral-mediated gene transfer
Authors: Phyllis W. Yu, Ruby S. Tabuchi, Roberta M. Kato, Alexander Astrakhan, Stephanie Humblet-Baron, Kevin Kipp, Keun Chae, Wilfried Ellmeier, Owen N. Witte, David J. Rawlings
Journal: Blood (2004)