tbuckley/cabot-search huggingface dataset:
Reviews and Notes: The Empathic Practitioner: Empathy, Gender, and Medicine
Authors: Mary Kay Schleiter
Journal: Annals of Internal Medicine (1995)

Literature of Medicine1 October 1995Reviews and Notes: The Empathic Practitioner: Empathy, Gender, and MedicineMary Kay Schleiter, PhDMary Kay Schleiter, PhDUniversity of Wisconsin-Parkside; Kenosha, WI 53141-2000Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-123-7-199510010-00028 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ES More and MA Milligan; eds. 255 pages. New Brunswick, NJ: Rutgers Univ Pr; 1994. $45.00 hardcover, $18.00 paper. ISBN 0-8135-2119-X. Order phone 800-446-9323.As the technology of medicine becomes ever more impersonal, concern about the human side of medical practice is not surprising. Caution about the dangers of uncoordinated specialized care is still practiced in the context of “body as machine” rather than “patient as person.” Concern about the physician–patient relationship—the so-called “bedside manner”—is often belittled as irrelevant to contemporary practice. In fact, medical training socializes future practitioners to let go of their human tendency to identify with the ... Author, Article, and Disclosure InformationAffiliations: University of Wisconsin-Parkside; Kenosha, WI 53141-2000 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1995Volume 123, Issue 7Page: 557KeywordsEmotionsForecastingMotivationScientistsSexual identity ePublished: 15 August 2000 Issue Published: 1 October 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Integrated Child Health Service
Authors: J. Davis, F. N. Bamford
Journal: BMJ (1973)

Integration means the unification of existing services and the development of new ones. The latter should include a system of monitoring parents' wishes, a 24-hour dispensary for children in urban areas, and a paediatric consultative service for social work departments. Work by family doctors in the infant health and school medical services should be facilitated and appropriate local authority clinicians should be equal partners with paediatricians in the assessment and care of the handicapped. The school medical service is not a single entity and local education authorities need co-ordinated advice from several doctors including family practitioners, paediatricians, and specialists in occupational and environmental medicine. More paediatricians are required to avoid single-handed practice and so that their work can be orientated towards die community.
Worcester General Infirmary. FIBRO-CELLULAR TUMOUR REMOVED FROM THE KNEE-JOINT
Authors: H. D. Carden
Journal: BMJ (1855)

hut mpo!lThe pain in the Usk and left hypochondrium have also disappeared.The sorenes in the epigastrium is diminished; but it and the throbbing still occur from time to ime.Ordered to take a little light pudding, made with eg; and to substitute biscuit-poWder for the ground-rice eacasionally.For medicine, to take five grains of the citato of iron thrice daily, dissolved in an ounce of water, with her food; and eight grains of the compound rhubarb pill, as an occasional aperient.June 26th.No pain or vomiting since the last report.S3till a good deal of soreness and tenderness to the slightest pressure.July 6th.Fasted for five hours, and took a fatiguing walk.This imprudence was immediately followed by an attack of pain, having the same character as previously, and relieved by the recumbent posture.It was not increased by cautiously taking a small quantity of the customary food, but returned about three hours after this meal.July 14th.Since the last report, was alarmed by a
Association between response to pegylated interferon/ribavirin therapy and ribavirin levels
Authors: Chia‐Yen Dai, Ming‐Lung Yu, Wan‐Long Chuang
Journal: Hepatology (2014)

Potential conflict of interest: Nothing to report. To the Editor: We read with great interest the article by Holmes et al.1 published in Hepatology. The researchers conclude that inosine triphosphatase (ITPase) deficiency protects against ribavirin (RBV)‐induced anemia, but that it is not associated with sustained virological response (SVR) to pegylated interferon (Peg‐IFN)‐α‐2a/RBV therapy in HCV genotype 1 (HCV‐1)‐infected patients from the CHARIOT study. Rapid virological response (RVR) has been considered the most important predictor for SVR, and an abbreviated treatment regimen was encouraged in patients with RVR and a low viral load.2 We wonder whether RVR (32.8%) had any effect on the result of the association between SVR and hemoglobin decline or upon RBV pharmacokinetics in the study by Holmes et al.1 It is known that plasma RBV levels at week 8, rather than the actual hemoglobin levels or ITPase deficiency in patients with HCV‐11 and genotype 2/3 infection,1 have been associated with SVR. Since the very important role of the genetic variation in interleukin (IL)28B on predicting response to Peg‐IFN‐based therapies either without3 or with new direct antiviral agents7 has been recognized, it seems also necessary to take the IL28B genotype into consideration in elucidating the influence of RBV levels on SVR in HCV‐1 patients, without otherwise detracting from the results by Holmes et al.1
Effect of Polymorphisms in the Beta2-Adrenergic Receptor Gene (ADRB2) on Response to Long-Acting Beta2-Agonist (LABA) Therapy
Authors: E.R. Bleecker, D.S. Postma, R. Lawrance, D.A. Meyers, H. Ambrose, M. Goldman
Journal: Journal of Allergy and Clinical Immunology (2007)
Comparison of oestradiol and prostaglandin E2 vaginal gel for ripening the unfavourable cervix
Authors: M Thiery
Journal: BMJ (1981)

number of patients going into labour following cervical ripening.Twelve of the 25 patients treated with PGE2 went into labour but only one of the oestradiol group did so (p = 0-0005).This lack of uterine stimulation may make oestradiol pretreatment preferable where placental function is suspect.Although the vaginal application may be more convenient than the extra-amniotic route, the high caesarean section rate reported (23% and 27%) by Mr Tromans and his col- leagues may make further studies on the best route of application worth while as the caesa- rean section rates in my series were 8% and 12%.Insertion of a Foley catheter may change the shape of the cervix.2In a study comparing routes of administration of PGE2 to ripen the cervix, Toplis and Sims3 found that the inci- dence of caesarean section following 3 mg vaginal paste was 15% compared with only 5% for 500 Cug given extra-amniotically.
How to write an effective referee report
Authors: Ushma S. Neill
Journal: Journal of Clinical Investigation (2009)

Most scientists learn how to review papers by being thrown into the deep end of the pool: here's a paper, write a review. Perhaps this is not the best way to keep an enterprise afloat. But what should be included in a review? What should the tone of a review be? Here I want to outline the specifics of what we at the JCI are looking for in a referee report.
Sick Building Syndrome-Reply
Authors: Jeffrey Engel
Journal: JAMA (1996)

In Reply.  —I agree with Dr Atkins' statement that the sick building syndrome has not been demonstrated to be of an allergic origin. I also concur with her advice regarding correction of air-handling systems in a building, rather than removing people from the workplace, as the treatment of choice for this illness. These points are particularly important when dealing with an epidemic associated with a unique environmental exposure.  However, the case for discussion was a single person with symptoms occurring 4 times a year, certainly not a history suggestive of an epidemic or a problem at the workplace. My comments were intended to broaden the differential diagnosis beyond infectious causes and remind readers that acute illnesses mimicking infections may be due to exposures to noxious stimuli other than microorganisms. Certainly, if the woman in this case can identify an environment that she encounters 4 times a year that triggers the
Venous thromboembolism risk among hospitalized patients: Magnitude of the risk is staggering
Authors: Samuel Z. Goldhaber
Journal: American Journal of Hematology (2007)

Quality assessment focuses on areas where measurement is easy and unequivocal. To determine whether high quality hospital medicine is being practiced, a natural target is assessment of the frequency of orders to implement preventive strategies against venous thromboembolism. Patient risk can be readily ascertained, and rigorous clinical trials have vetted effective strategies to prevent deep vein thrombosis and pulmonary embolism. Concentrating on reducing the risk of venous thromboembolism is worthwhile because more than 4 million surgical patients and almost 8 million medical patients warrant specific prophylaxis orders each year in the United States alone. For those who do not receive preventive measures, the result may not be apparent during the index hospitalization. More likely, such patients will tend to develop deep vein thrombosis or pulmonary embolism within the ensuing 90 days, either in a skilled nursing facility or at home in the community. It is now time for us to broaden our approach. What happens in the hospital (such as lapses in good hospital practice) does not necessarily stay in the hospital. Failure to prophylax against venous thromboembolism may have potentially devastating implications for months after hospital discharge.
Platelet membrane glycoprotein IIIa contains target antigens that bind anti-platelet antibodies in immune thrombocytopenias.
Authors: D S Beardsley, J E Spiegel, M M Jacobs, R I Handin, S E Lux
Journal: Journal of Clinical Investigation (1984)

The precise pathogenic mechanism of platelet destruction in immune thrombocytopenias is not known, although many investigators have found that platelet-associated IgG is increased in these diseases. We report here the differentiation between specific binding of anti-platelet antibody, associated with platelet destruction, and the ubiquitous presence of nonspecific, platelet-associated IgG. Using an electrophoretic separation and antibody overlay technique, we have identified a specific membrane protein that bears target platelet antigens in immune thrombocytopenias. When posttransfusion purpura serum was studied, antibody binding to the PlA1 antigen on glycoprotein IIIa was readily distinguished from the nonspecific binding of immunoglobulin to a protein of 200,000 mol wt. After reduction of disulfide bonds, the PlA1 antigenicity was not observed, and IgG bound nonspecifically to a protein band with an apparent molecular weight of 45,000. We have also identified anti-platelet antibodies in patients with idiopathic thrombocytopenic purpura and determined their antigenic specificity. Antibodies which bind to a 100,000-mol wt protein were found in nine of thirteen patients with chronic disease. The antigens in three of these cases were studied in detail by using both reduced and nonreduced control and Glanzmann's thrombasthenic platelets. Target antigens were localized to glycoprotein IIIa, but are different from PlA1. The immune thrombocytopenic purpura antigenic system is clearly distinguished from nonspecific platelet-associated IgG. Sera from eight children with acute idiopathic thrombocytopenic purpura were also studied. In all cases, the nonspecific IgG binding to the 200,000-mol wt protein was observed. However, we were unable to demonstrate antibody binding to glycoprotein IIIa, which suggested that the acute childhood form of this disease may have a different pathogenic mechanism than that of the autoimmune chronic cases.
NON-UNION OF FRACTURE OF THE SHAFT OF THE FEMUR TREATED BY EXERCISE.
Authors: G. W. NESBITT
Journal: JAMA (1884)

(Read before the Surgical Section of the American Medical Association June, 1882.) Non-union of broken bones is so uncommon an event in surgery, that it has been estimated that it does not occur in a larger proportion that one in five hundred fractures. And as fractures of the shaft of the femur constitute but a small per cent. of all fractures, it must follow, that not one physician in ten, in general practice, will meet with one case in a lifetime, unless his treatment of fractures should be exceptionally bad. But should the one case fall to either of you, you will, after having exhausted the resources of written surgical authorities, and taxed your own patience and ingenuity to the utmost, most gladly avail yourselves of any practical hints upon the subject, however humble the source, before subjecting your patient to the peril and uncertainty of a resection, or the
Diabetes in the developing world
Authors: Z. Lakhani
Journal: BMJ (1995)

EDITOR,—As a physician with origins in east Africa and with continuing medical links in that region, I was heartened by K G M M Alberti's concern for those who have a “right to life and at a small cost per patient by Western standards.”1 The difficulty in dealing with what is essentially a long term management challenge (a diabetic patient presenting at age 17 may well require insulin for another 40 years or so) rests in being able to guarantee …
DIAPHRAGMATIC PLEURISY ARACHNIDISM
Authors: George L. Carrington
Journal: JAMA (1927)

<h3>To the Editor:</h3> —I have received from Dr. Emil Bogen an interesting reprint and copy of a letter to you relative to a case reported by me (The Journal, April 30, p. 1395) as one of bilateral diaphragmatic pleurisy simulating perforated gastric ulcer. Dr. Bogen suggests that it was a case of arachnidism. Such a diagnosis was considered before operation and the history of spider bite included as relevant. The day following operation, however, the appearance was that of a respiratory infection, with leukocytosis of 19,000; and this appearance became more marked as the respirations rose from 30 to 48 per minute. The later occurrence and persistence of definite, clear and unmistakable dry pleural friction rubs anteriorly, posteriorly and in the axilla on both sides at the level of the diaphragm just about indisputably establish a diagnosis of bilateral diaphragmatic pleurisy. To suppose an arachnidism also would necessitate the supposition
The HUNTERIAN LECTURES on the SURGERY of the KIDNEY: Delivered at the Royal College of Surgeons of England
Authors: H. Morris
Journal: BMJ (1898)

nuclein and nucleinic acid in the treatment of microbic diseases; but I am not aware that it has been tried except in the treatment of tuberculosis, although it has been advocated both in the form of the original preparations of de Backer -and as nuclein solutions in the treatment of all microbic affections.It occurred to me that nuclein derived from the _young yeast cells may have been the material responsible for the apparent usefulness of yeast in Sir W. Broadbent's and my cases, and that it was worthy of trial in cases at all events in which antistreptococcus serum would not be applicable.The only case of infective endocarditis in which 1 have used nuclein is one seen by me in consultation with Dr.Christopherson of Hastings.The effect appears to be very striking, the temperature coming down to normal for twenty- two days, after which, however, another rise occurred.CONCLUSION.I regret that time has not allowed me to allude more fully to some forms of cardiac disease, more especially to the sub- ject of senile and prematurely degenerative diseases of the heart.A reference to them must have been somewhat discursive, for whilst they admit of much management, they necessarily allow of little direct treatment.And, indeed, in trying to seek out points for treatment which are scattered here and there amidst groups of symptoms, I fear I have al- ready been too discursive.My endeavour has been to illustrate the principles of treatment rather than to touch upon details, the recognition of a neuropathic state, the principle of rest, Qf exercise, of drug administration, of restrictions in diet, upon which we formulate our more precise management of individual cases.Finally, we must accept in cardiac therapeutics the principle of submission, so that we may better help patients to recognise the necessity of a reetricted life caged within the narrowed limits of those con- ditions under which alone life can be maintained.
Cribriform Morular Variant of Papillary Thyroid Carcinoma in a Patient with an Incidental Neck Lump: a Case Report and Review of the Literature
Authors: Ester Chai Kheng Yeoh, Ling Choo Lim, Siok Bian Ng, Kok Yang Tan, C. Rajasoorya
Journal: Endocrine Pathology (2013)
Omeprazole to Prevent Recurrent Bleeding after Endoscopic Treatment of Ulcers
Authors: Eric D. Libby
Journal: New England Journal of Medicine (2000)

The management of peptic ulcer disease has changed greatly during the past three decades. Infection with Helicobacter pylori is now recognized as the cause of most ulcers, the use of endoscopy has improved diagnosis, antisecretory drugs are available to suppress the production of gastric acid, and the majority of patients with peptic ulcer disease can be treated medically without having to undergo surgery. Despite these remarkable advances, hemorrhage from gastric or duodenal ulcers remains a common reason for hospitalization. In the United States, more than 250,000 patients are hospitalized with upper gastrointestinal bleeding each year, and peptic ulcer disease is . . .
Dendritic cell-based immunotherapy for prostate cancer
Authors: B. A. Tjoa, P. A. Lodge, M. L. Salgaller, A. L. Boynton, G. P. Murphy
Journal: CA A Cancer Journal for Clinicians (1999)

CA: A Cancer Journal for Clinicians publishes information about the prevention, early detection, and treatment of cancer, as well as nutrition, palliative care, survivorship, and additional topics of interest related to cancer care.
THE FORMATION OF THE CORPUS LUTEUM IN THE GUINEA-PIG.
Authors: LEO LOEB
Journal: JAMA (1906)

<h3>HISTORY OF RESEARCH.</h3> Three considerations make it desirable to undertake a detailed study of the development of the corpus luteum of the guinea-pig. 1. Although a number of very careful investigations on the development of the corpus luteum have been published within the last ten years, there are a number of essential points about which different writers still disagree. It is not necessary to give a review of the literature on this subject, as this has been done repeatedly within recent years.<sup>1</sup>In regard to the development of the corpus luteum of the guinea-pig, there exists a short paper of Belloy,<sup>2</sup>who does not give distinct statements in regard to the age of the different corpora lutea which he describes. His results are in some important points opposed to the results obtained in other animals by different investigators. The most recent paper on the development of the corpus
SEVERITY OF PERIODONTAL DISEASE IS ASSOCIATED WITH URINARY ALBUMIN EXCRETION INDEPENDENTLY OF SYSTEMIC INFLAMMATION IN HYPERTENSIVE PATIENTS
Authors: A. Kasiakogias, K. Tsioufis, C. Thomopoulos, N. Soldatos, A. Kordalis, L. Lioni, E. Stefanadi, S. Sideris, M. Giakoumis, C. Stefanadis
Journal: Journal of the American College of Cardiology (2011)
Neurogenesis or non-neurogenesis: that is the question
Authors: Gianvito Martino, Erica Butti, Marco Bacigaluppi
Journal: Journal of Clinical Investigation (2014)

Neural stem/precursor cells (NPCs) that reside within germinal niches of the adult CNS have more complex roles than previously expected. In addition to their well-documented neurogenic functions, emerging evidence indicates that NPCs exert non-neurogenic functions that contribute to the regulation and preservation of tissue homeostasis under both physiological and pathological conditions. In this issue of the JCI, Mohammad et al. found that DCs efficiently patrol the CNS only when the germinal niche of the subventricular zone functions properly. Indeed, DCs traveled from the ventricles along the rostral migratory stream to the olfactory bulb (a cervical lymph node access point) to dampen anti-CNS immune responses. The authors' findings further support a non-neurogenic role for NPCs in maintaining tissue homeostasis and promoting tissue protection in the adult brain.
Effects of nifedipine on systemic and regional oxygen transport and metabolism at rest and during exercise.
Authors: C Y Choong, G S Roubin, W F Shen, P J Harris, D T Kelly
Journal: Circulation (1985)

In a placebo-controlled, randomized, cross-over, double-blind study of 12 patients with stable exertional angina, we measured at rest and during bicycle exercise the effects of 20 mg of nifedipine administered sublingually on hemodynamics and systemic and regional oxygen extraction and metabolism. Nifedipine decreased systemic vascular resistance by 38% at rest (p less than .001) and by 28% during exercise (p less than .001). Cardiac output increased from 4.6 +/- 0.6 to 6.0 +/- 0.9 liters/min (p less than .001) at rest after nifedipine and from 10.6 +/- 3.7 to 11.8 +/- 3.4 liters/min (p less than .005) during exercise. After nifedipine, the arterial-mixed venous O2 content difference decreased from 4.7 +/- 0.6 to 3.5 +/- 0.5 ml/100 ml (p less than .001) at rest and from 10.5 +/- 1.7 to 8.8 +/- 1.6 ml/100 ml (p less than .001) during exercise. After nifedipine the arterial-iliac venous O2 content difference also decreased at rest, from 5.9 +/- 1.5 to 4.8 +/- 1.7 ml/100 ml (p = .06) but increased during exercise from 13.1 +/- 1.5 to 14.0 +/- 1.8 ml/100 ml (p less than .05). Oxygen consumption was not significantly altered at rest or during exercise. Nifedipine decreased mixed venous carbon dioxide tension (PCO2) during exercise from 53 +/- 3.5 to 50 +/- 4.0 mm Hg (p less than .05) but increased iliac venous PCO2 slightly from 61 +/- 4.6 to 63 +/- 5.2 mm Hg (p less than .01). Exercise pH was not significantly altered, but arterial lactate increased more after nifedipine (2.65 +/- 1.95 mmol/liter placebo, 3.54 +/- 2.74 mmol/liter nifedipine; p less than .05). Thus nifedipine produces similar changes in O2 extraction in mixed venous and iliac venous blood at rest but directionally opposite changes during exercise. The data support the hypothesis that nifedipine does not alter the distribution of cardiac output to the legs at rest, but during dynamic leg exercise reduces the redistribution of cardiac output to the legs. This probably results from the shunting of blood flow away from exercising muscles by the generalized vasodilatation of nifedipine.
Can radiofrequency data analysis of intravascular ultrasound accurately characterize coronary atherosclerosis?
Authors: M.Pauliina Ramo, Timothy Spencer, George R. Sutherland, Donald M. Salter, Peter Kearney, David Lamb, T.R.D.Stuart Shaw, Norman W. McDicken, Raimund Erbel, Peter Fitzgerald
Journal: Journal of the American College of Cardiology (1996)