tbuckley/cabot-search huggingface dataset:
National Transplant Communications Network
Authors: Paul I. Terasaki
Journal: JAMA (1971)

A National Communications Network for cadaver kidney transplant sharing in the United States and Canada has been established and has been functional for 1 1/2 years. Currently, a total of 864 waiting recipients from 61 transplant centers are kept on the computerized file. Through this network a total of 215 kidneys have been exchanged; 40 kidneys originated from nontransplanting hospitals and 175 from transplant centers. This type of interhospital cooperation for the treatment of patients is a new development and is essential for the complete utilization of valuable organs and for the development and evaluation of histocompatibility methods in transplantation.
Novel CLCN5 mutations in patients with Dent’s disease result in altered ion currents or impaired exchanger processing
Authors: Teddy Grand, David Mordasini, Sébastien L'Hoste, Thomas Pennaforte, Mathieu Genete, Marie-Jeanne Biyeyeme, Rosa Vargas-Poussou, Anne Blanchard, Jacques Teulon, Stéphane Lourdel
Journal: Kidney International (2009)
Rapid response to 2′‐deoxycoformycin in advanced hairy cell leukemia after failure of interferons alpha and gamma
Authors: Barry C. Lembersky, Mark J. Ratain, Carol Westbrook, Harvey M. Golomb
Journal: American Journal of Hematology (1988)

Abstract A patient with advanced hairy cell leukemia initially had a short‐lived minor response to interferon alpha therapy and failed to respond to interferon gamma. Subsequent treatment with 2′‐deoxycoformycin (dCF) administered biweekly for 12 wk resulted in a complete hematological remission which has continued for 16 months without additional therapy.
Principles of Economic Analysis of Health Care Technology
Authors: Jose Antonio Sacristan
Journal: Annals of Internal Medicine (1996)

Letters1 March 1996Principles of Economic Analysis of Health Care TechnologyJose Antonio Sacristan, MD, Javier Soto, MD, and Jesus M. Hernandez, MDJose Antonio Sacristan, MDMadrid, SpainSearch for more papers by this author, Javier Soto, MDMadrid, SpainSearch for more papers by this author, and Jesus M. Hernandez, MDMadrid, SpainSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-124-5-199603010-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In a recent editorial on economic analysis of health care technologies, Evans [1] states, “Since the new sponsors of research [pharmaceutical companies] have such an obvious commercial interest in the outcomes, why should we believe them?”Pharmaceutical companies are interested in developing drugs with clinical and economic advantages. This could lead to a potential bias in the conduct and reporting of company-sponsored cost-effectiveness analyses [2]. Dr. Evans seems to forget, however, that other potential sources of bias may exist, such as the interest of a payer to reduce its total health expenditure budget. Would it not be ...References1. Evans RG. Manufacturing consensus, marketing truth: guidelines for economic evaluation [Editorial]. Ann Intern Med. 1995; 123:59-60. Google Scholar2. Hillman AI, Eisenberg JM, Pauly MV, Bloom BS, Glick H, Kinosian B, et al. Avoiding bias in the conduct and reporting of cost-effectiveness research sponsored by pharmaceutical companies. N Engl J Med. 1991; 324:1362-5. Google Scholar3. Sacristan JA, Navarro O, Casado MA, Reviriego J, Soto J. Publication bias in pharmacoeconomic studies? Eighth International Conference on Pharmaceutical Medicine. Rome; 27-29 April 1994. Google Scholar4. Task Force on Principles for Economic Analysis of Health Care Technology. Economic analysis of health care technology. A report on principles. Ann Intern Med. 1995; 122:61-70. Google Scholar Author, Article, and Disclosure InformationAuthors: Jose Antonio Sacristan, MD; Javier Soto, MD; Jesus M. Hernandez, MDAffiliations: Madrid, Spain PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCritical issues in the economic evaluation of interventions against communicable diseases 1 March 1996Volume 124, Issue 5Page: 535-536KeywordsDrug research and developmentDrugsHealth careHealth economicsResearch quality assessment ePublished: 15 August 2000 Issue Published: 1 March 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Targeting Cellular Prion Protein Reverses Early Cognitive Deficits and Neurophysiological Dysfunction in Prion-Infected Mice
Authors: Giovanna R. Mallucci, Melanie D. White, Michael Farmer, Andrew Dickinson, Husna Khatun, Andrew D. Powell, Sebastian Brandner, John G.R. Jefferys, John Collinge
Journal: Neuron (2007)
Risk for Bipolar Illness in Patients Initially Hospitalized for Unipolar Depression
Authors: Joseph F. Goldberg, Martin Harrow, Joyce E. Whiteside
Journal: American Journal of Psychiatry (2001)

OBJECTIVE: To assess the risk for subsequent development of mania or hypomania, the authors conducted a 15-year prospective follow-up study of a large, young cohort of patients originally hospitalized for unipolar major depression. METHOD: Patients who were hospitalized for unipolar major depression (N=74; mean age=23.0 years, SD=3.8) were assessed prospectively as inpatients and then followed up five times over 15 years, at approximately 2, 5, 8, 11, and 15 years after discharge. Manic or hypomanic episodes, medications, and rehospitalizations were determined by standardized assessments at each follow-up. Polarity conversions were evaluated by survival analyses. RESULTS: By the 15-year follow-up, 27% of the study group had developed one or more distinct periods of hypomania, while another 19% had at least one episode of full bipolar I mania. Depressed patients with psychosis at the index depressive episode were significantly more likely than nonpsychotic patients to demonstrate subsequent mania or hypomania at follow-up. Those with family histories of bipolar illness showed a nonsignificantly higher rate of switching to mania or hypomania. Spontaneous and antidepressant-associated manias did not differ in frequency. Fewer than one-half of the patients who showed an eventual bipolar course had received prescriptions for mood stabilizers in any follow-up year. CONCLUSIONS: Young depressed inpatients with psychotic features may be at especially high risk for eventually developing mania. The probability for developing a bipolar spectrum disorder increases in linear fashion for patients at risk for polarity conversion during the first 10–15 years after an index depressive episode.
Expression of cyclooxygenase-2 promotes the release of matrix metalloproteinase-2 and -9 in fetal rat hepatocytes
Authors: Nuria A. Callejas, Marta Casado, María J.M. Díaz-Guerra, Lisardo Boscá, Paloma Martín-Sanz
Journal: Hepatology (2001)

Treatment of primary cultures of fetal hepatocytes with proinflammatory cytokines, lipopolysaccharide (LPS), and hepatocyte growth factor promoted the expression of cyclooxygenase–2 (COX–2) and the synthesis of high amounts of prostaglandins (PGs). Under these conditions, the active forms of the matrix metalloproteinases–2 and –9 (MMPs) were released to the extracellular medium. This process was inhibited when the synthesis of PGs was suppressed pharmacologically with COX–2 inhibitors. Addition to the cell cultures of PGE 2 promoted the release of MMPs through a mechanism that involved the expression of COX–2 and the synthesis of additional PGs. Kinetic analysis of the secretion of MMPs in response to LPS and PGE 2 showed a similar time course, with a lag period of 6 hours, which suggests that PGE 2 does not act directly on the mechanism of MMP processing and release. Inhibitors of protein kinase A, p38 MAP kinase, phosphatidylinositol–3–kinase, and nuclear factor κB (NF–κB) activation impaired the release of MMPs in response to PGE 2 challenge, indicating the involvement of multiple steps in the process. The ability of fetal hepatocytes to release MMPs in response to growth factors and inflammatory stimuli constitutes a model for the study of the extracellular matrix remodeling that accompanies most liver diseases.
Progress in Diabetes Research—What's Next
Authors: David M. Nathan
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ruptured atheromatous plaques in saphenous vein coronary artery bypass grafts: a mechanism of acute, thrombotic, late graft occlusion.
Authors: A E Walts, M C Fishbein, H Sustaita, J M Matloff
Journal: Circulation (1982)

Although early occlusion of saphenous vein coronary artery bypass grafts is usually thrombotic, late occlusion is most often a result of progressive intimal fibromuscular proliferation or atheroma formation in the implanted vain. We describe another mechanism of late graft occlusion: atheromatous plaque rupture with superimposed occlusive thrombosis. Four men, ages 48-67 years underwent repeat bypass surgery for recurrent angina. Six of eight vein grafts excised 5-8 years after original bypass showed complete luminal occlusion by recent thrombus superimposed on ruptured atheromatous plaques. Similar findings were present at autopsy in two of three vein grafts from a 66-year-old man who died 7 years after bypass. These lesions are indistinguishable from those that occur in native coronary arteries of many patients with acute myocardial infarction. Unlike previously described graft occlusions, the present lesion represents a mechanism of acute, thrombotic, late graft occlusion. If recognized early, it may be amenable to nonsurgical intervention by angioplasty or thrombolysis.
PROPHYLACTIC VALUE OF BLOOD OF CONVALESCENTS IN MEASLES
Authors: SIDNEY V. HAAS
Journal: JAMA (1926)

For nearly two hundred years, attempts have been made to immunize against measles. To Home<sup>1</sup>of Scotland is ascribed the first attempt at active immunization by vaccination with human blood, and also by the transplantation of nasal mucus, on a swab of cotton from a child having measles, on the nasal mucous membrane of another child. Hektoen<sup>2</sup>was the first to use a mixture of incubated human blood and ascites broth in an attempt to induce a mild form of infection. Recently, Herrman<sup>3</sup>has suggested a method of active immunization, making use of the well established fact that infants under 5 months of age are practically immune to measles. His method is to take the nasal mucus of a patient with measles, from twenty-four hours before to twenty-four hours after the eruption, and transplant it on the nasal mucous membrane of another infant. This transference, in many
Addition of Misonidazole, Etanidazole, or Hyperthermia to Treatment With Fluosol-DA/Carbogen/Radiation
Authors: B. A. Teicher, T. S. Herman, S. A. Holden, S. M. Jones
Journal: JNCI Journal of the National Cancer Institute (1989)

The antitumor efficacy of adding the nitroimidazole radiosensitizing drugs misonidazole and etanidazole or hyperthermia (43 °C for 30 min) to Fluosol-DA/carbogen (95% O2/5% CO2) and irradiation was tested in the FSaIIC tumor system. Both the nitroimidazole drugs and hyperthermia produced additional tumor growth delays and tumor cell cytotoxkity when given with Fluosol-DA/carbogen, either before or after irradiation. For each of the modalities tested, the dose-modifying effect was greater when that therapy preceded rather than followed irradiation (misonidazole 2.7 vs. 1.9, etanidazole 2.4 vs. 1.7, hyperthermia 4.0 vs. 1.7 relative to the effect of radiotherapy alone). Because the nitroimidazole drugs must be present before radiation is administered to exert their radiosen-sitizing effect, the increase in tumor growth delay observed when these drugs cytotoxic to hypoxic cells were administered following Fluosol-DA/carbogen and irradiation suggests that Fluosol-DA/carbogen could not fully oxygenate the tumors and that the nitroimidazole drugs were effectively toxic to residual hypoxic cells. The treatment Fluosol-DA/carbogen→ hyperthermia→ irradiation produced a marked increase in tumor growth delay not seen with the sequence F1uosol-DA/carbogen→irradiation→hyperthermia. The results indicate that a treatment combination of radiation sensitizers may be more effective than irradiation plus Fluosol-DA with oxygen breathing alone. [J Natl Cancer Inst 81:929-934, 1989]
Determination of glucocorticoid receptors in leukemic myeloblasts by isoelectric focusing in polyacrylamide gel
Authors: Claudio Ogier, Solveig Humla, Bo Nordenskjöld, Lambert Skoog
Journal: American Journal of Hematology (1985)

We investigated the optimal conditions for measuring glucocorticoid receptor in blast cells from patients with acute nonlymphocytic leukemia. Cytosol receptor measured with isoelectric focusing was saturated after 60 min of incubation at 0 degrees C with 100 nM of either dexamethasone or triamcinolone. Saturation was achieved when cytosol from at least 7 X 10(6) cells was used for incubation. Trypsin treatment of the cytosol resulted in a sharpened peak of receptor focusing at pH 5.6 with no loss of receptor-bound radioactivity. The two physical forms of glucocorticoid receptor were isolated with DEAE cellulose chromatography. They were both found to focus at pH 5.6 during isoelectric focusing.
Abstract 3290: Glucose-regulated protein 58 modulates β-catenin protein stability in cervical adenocarcinoma
Authors: Chia-Jung Liao, Syuan-ling Lin, Tzu-Hao Wang, Kwang-Huei Lin
Journal: Cancer Research (2014)

Abstract Cervical cancer is still a serious problem threatening to women health worldwide. The incidence of cervical adenocarcinoma (AD) is rising in more developed countries. Previously we have identified that glucose-regulated protein 58 (Grp58) serves as a poor independent prognostic factor for cervical AD. The molecular mechanism underlying Grp58 involved cervical AD carcinogenesis is unknown. The DNA microarray and enrichment analysis were used to identify pathway maps perturbed by knockdown of Grp58 expression. The WNT singling map is one of the significant enriched pathways. The β-catenin, vital effector of WNT signaling, was stably accumulated in Grp58 knockdown stable cells. A membrane fashion of β-catenin was observed in Grp58 knockdown but not control cells. By using transwell assay, we have demonstrated that accumulation of β-catenin, which was induced by Grp58 knockdown or lithium chloride treatment, inhibited the migration ability of HeLa cell. Furthermore, an exclusive expression pattern of Grp58 and β-catenin was observed in cervix tissues. In sum, we have demonstrated that β-catenin stability is negatively regulated by Grp58. Overpression of Grp58 might result in lost or decreased of membranous β-catenin in cervical cancer to promote cancer progression. Citation Format: Chia-Jung Liao, Syuan-ling Lin, Tzu-Hao Wang, Kwang-Huei Lin. Glucose-regulated protein 58 modulates β-catenin protein stability in cervical adenocarcinoma. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3290. doi:10.1158/1538-7445.AM2014-3290
OBSERVATIONS ON GROUP PSYCHOTHERAPY WITH HOSPITALIZED PATIENTS
Authors: AARON H. CANTER
Journal: American Journal of Psychiatry (1955)

We have presented some observations regarding group therapy. In the opinion of the writer, group therapy has certain specific and unique advantages for the acutely disturbed patient of the type described. These advantages are: (1) schizophrenics appear to be able to understand one another's behavior and symbolic productions successfully; (2) the learning of new behavioral patterns or modification of old behavior is best achieved for some patients in group therapy; (3) group therapy facilitates the transition and adjustment of the patient to the hospital, and to discharge from the hospital; (4) group psychotherapy greatly facilitates the patient's ultimate adjustment to society.
MR enterography in the investigation of abdominal pain
Authors: J. Makanyanga, A. Srivastava, J. Gan, S. M. Dhana, P. Khana, V. Muthuppalaniappan, S. Jain, M. McStay
Journal: Gut (2011)

<h3>Introduction</h3> Magnetic Resonance Enterography (MRE) has an established role in the management of patients with small bowel Crohn9s disease1 and has the advantages of diagnosing extra-enteric lesions which may be clinically significant2 and being free from the risks of radiation exposure. There is little published data on the use of MRE in the investigation of patients with chronic abdominal pain. <h3>Methods</h3> A retrospective review of case notes was conducted of 167 patients who underwent MRE at Southend University Hospital for abdominal pain between April 2008 and August 2010 and did not have a pre-existing diagnosis of inflammatory bowel disease (IBD) by colonoscopy or capsule endoscopy. MRE was performed using a 1.5 Tesla MR scanner following a minimum 6 h fast and bowel preparation with Kleen prep an hour prior to the scan. Two T2-weighted sequences single-shot fast spin-echo (SSFSE) and fast imaging employing steady state acquisition (FIESTA) were performed in the axial and coronal planes. <h3>Results</h3> 51 Male and 106 Female patients had MRE for abdominal pain during the study period. The mean age was 42.2 years (range 14–85 years). 34.7% (58/167) of cases had a contrast abdominal CT scan prior to the MRE. MRE found clinically significant abnormalities in 16.8% (28/167). 13 of these patients had a prior CT scan and in 8 cases MRE was used to clarify CT findings. The findings were as follows: –12 SB Crohn9s (5 CT suggestive) –1 adhesional SB Obstruction (1 CT normal) –1 radiation induced small bowel stricture –1 GIST – leiomyoma at resection (normal CT and gastroscopy) –3 SB carcinoid – confirmed at resection (1 capsule endoscopy abnormal, 1 CT suggestive) –1 jejunal tumour – adenocarcinoma at resection (normal CT) –1 duodenal mass with intussusception – villous adenoma at resection (CT suggestive) –1 left adrenal mass –1 ovarian endometrioma –1 renal cell carcinoma – confirmed at resection –1 peritoneal metastases – metastatic breast carcinoma at biopsy (CT colonic thickening and free fluid, normal colonoscopy) –1 Meckel9s diverticulum –1 intussusception –1 splenic mass – granuloma at resection (CT abnormal) –1 reactive lymph nodes with jejunal thickening (CT abnormal) <h3>Conclusion</h3> MRE is a useful investigation for chronic abdominal pain in patients without a prior diagnosis of IBD. It yields clinically significant enteric and extra-enteric findings and carries no risk of radiation exposure.
Viral folliculitis on the face
Authors: K-A. Jang, S-H. Kim, J-H. Choi, K-J. Sung, K-C. Moon, J-K. Koh
Journal: British Journal of Dermatology (2000)

Abstract The common clinical presentations of herpes simplex virus (HSV) and molluscum contagiosum (MC) are well known to dermatologists. However, folliculitis due to these viruses is an infrequently reported entity and might be considered a sign of immunosuppression [such as infection with human immunodeficiency virus, (HIV)], especially in cases of folliculitis due to MC. The purpose of this study was to describe the clinical and histopathological characteristics of viral folliculitis due to HSV and MC. We retrospectively collected all our cases with histologically proven folliculitis due to HSV and MC between 1994 and 1999. A total of seven patients aged 7–54 years was identified. Prior to establishment of the diagnosis of folliculitis due to HSV and MC, they were treated with topical antibiotics or topical steroids, without improvement. Tentative diagnoses were bacterial folliculitis, syringoma, perifollicular fibrosis, contact dermatitis or pseudolymphoma. Biopsy of the lesions revealed multiple molluscum bodies in the follicular epithelium with sparing of the epidermis in four patients, and ballooning degeneration and intranuclear viral inclusions in the follicular epithelium in the other three. Three patients had evidence of underlying immune suppression, such as pregnancy, chronic viral hepatitis B and nasopharyngeal carcinoma. One patient had suffered from epilepsy for 4 years. Testing for HIV by enzyme-linked immunosorbent assay was negative in the four patients in whom this was performed, and T-cell subsets were normal in the three patients in whom these were quantified. In cases of molluscum folliculitis treated with simple curettage, the lesions cleared without scarring or recurrence. In cases of herpetic folliculitis, the lesions improved with antihistamines or aciclovir. MC or HSV should be considered in cases that present with folliculitis-like dermatoses but which are refractory to anti-infective and anti-inflammatory treatment.
Prolonged Survival in Down Syndrome
Authors: Aran Kasparyan
Journal: JAMA (1977)

To the Editor.—  I read with interest the recent article by Dr C. H. McGowen (237:673, 1977) entitled Prolonged Survival in a Patient with Down Syndrome.  I have worked with mentally retarded persons for more than 13 years and have had the opportunity and experience of providing medical care to many patients with Down syndrome. One of my patients who died in 1971 was 70 years 11 months of age. Another patient died in 1973 at the age of 68 years 4 months. Finally, another who died just two months ago was aged 66 years 10 months. The oldest resident with a diagnosis of Down syndrome present at this school is 65 years 3 months of age.  If Dr McGowen inquires of other state facilities for the mentally retarded or perhaps throughout the country, I am sure that he will find many patients with Down syndrome who are more than
Monocyte chemoattractant protein-1 mediates collagen deposition in experimental glomerulonephritis by transforming growth factor-β
Authors: André Schneider, Ulf Panzer, Gunther Zahner, Ulrich Wenzel, Gunter Wolf, Friedrich Thaiss, Udo Helmchen, Rolf A.K. Stahl
Journal: Kidney International (1999)
MODERNE THERAPIE DER NEUROSYPHILIS. (MIT EINSCHLUSS DER PUNKTIONSTECHNIK UND LIQUORUNTERSUCHUNG). By <i>Bernhard Dattner.</i> One volume with 334 pages and 36 illustrations, 36 charts, 9 curves and 8 multicolored plates. (Vienna IX: Wilhelm Maudrich, 1933.)
Authors: None Dieterle
Journal: American Journal of Psychiatry (1933)