tbuckley/cabot-search huggingface dataset:
Pharmacology and Treatment Isoquinoline is a possible anti-psoriatic agent in coal tar
Authors: M.I. FOREMAN, M. TAYLOR, C. CLARK, H. DEVITT, G. HANLON, I. KELLY, G. LUKOWIECKI
Journal: British Journal of Dermatology (1985)

Isoquinoline has been identified as a component of coal tar which causes interfollicular regions of parakeratotic stratum corneum in mouse tail epidermis to become orthokeratotic, with concomitant production of a granular layer. In this respect it behaves similarly to coal tar itself, and isoquinoline may contribute to the anti-psoriatic activity of coal tar.
Phase II study of bevacizumab with liposomal doxorubicin for patients with platinum- and taxane-resistant ovarian cancer
Authors: C.F. Verschraegen, S. Czok, C.Y. Muller, L. Boyd, S.J. Lee, T. Rutledge, S. Blank, B. Pothuri, S. Eberhardt, F. Muggia
Journal: Annals of Oncology (2012)
SLE-Related Choroidopathy Depicted by ln-111 Leukocyte Imaging
Authors: RICHARD TUPLER, FRANK MADONNA, ELLIOTT H. TURBINER
Journal: Clinical Nuclear Medicine (1991)

SLE immune deposits have been described in a few patients in the choroid plexus and are even postulated as a pathogenetic mechanism in CNS lupus. Patients with CNS lupus may experience acute clinical symptomatology manifested as nausea, vomiting, and decreasing neurologic status. We report a case of clinically inapparent choroidopathy in a young patient with SLE, correctly identified with ln-111 labeled leukocyte imaging.
Cavernous chylangioma of jejunal mesentery.
Authors: A C Branfoot
Journal: BMJ (1971)

specific infection, seems a convincing argu- ment for routine testing by general practi- tioners of the sexually-active women patients on their lists.Even if a large majority of women examined should prove to be free from any form of genital infection, routine screening programmes-wherever carried out -offer the only means of eventually controlling sexually-transmitted disease.-Weare, etc.,
Myasthenia Gravis in Identical Twins
Authors: D. Osborne, J. Simcock
Journal: BMJ (1966)

Medical MemorandaMEDIALS 1025 uric acids were estimated in male in-patients who were given frusemide without regard to their particular disorder except that they required diuretic therapy.Similarly, control values were estimated on patients not receiving frusemide.The results were as shown in Fig. 1. 9 Frusemide Mersolyl.Frusemide
Mechanisms determining the behaviour of the left atrial pressure during cardioplegia.
Authors: J B Johnston, G R Pritchard, J S Wright
Journal: Thorax (1966)

The technique of inducing profound hypothermia by peripheral cannulation in man without opening the chest and using a heart-lung machine does not permit the surgeon to vent the left side of the heart (Woodhall, Sealy, Hall, and Floyd, 1960; Patterson and Ray, 1962).In open-heart surgery this is considered to be a vital step in preventing dilatation of the left heart and the pulmonary vasculature from continuing bronchial venous return.Indeed, if this is not done, in particular in the repair of defects with a large bronchial circulation, e.g., tetralogy of Fallot, the left heart may be irreversibly damaged by distension and the pulmonary vasculature may likewise be damaged beyond repair.This latter state was considered to be one of the most potent causes of the perfusion lung syndrome in the early days of bypass.Nevertheless when this method is used to produce profound hypothermia when operating on intra- cranial aneurysms little difficulty is experienced in reversing ventricular fibrillation to sinus rhythm, and post-operatively cardiopulmonary difficulties are minimal (Patterson and Ray, 1962; Michen-
Compression of Pulmonary Artery by Syphilitic Thoracic Aortic Aneurysm: Imaging
Authors: DIANA S. PRESTON, PATRICK M. COLLETTI, JANAK K. RAVAL, D RANDALL RADIN
Journal: Clinical Nuclear Medicine (1989)

A case of syphilitic aortitis with multiple thoracic aneurysms, one of which caused compression of the left pulmonary artery with hypoperfusion of the left lung as seen with perfusion scintigraphy, blood pool studies, CT, and magnetic resonance imaging is presented.
Dowling-Degos disease associated with squamous cell carcinomas on the dappled pigmentation
Authors: M. Ujihara, T. Kamakura, M. Ikeda, H. Kodama
Journal: British Journal of Dermatology (2002)

We report the first case of Dowling–Degos disease associated with squamous cell carcinomas (SCCs) in the pigmented area of Dowling–Degos disease. A 64-year-old Japanese man manifested dappled pigmentation unusually localized to the buttocks, and two pigmented adenoid SCCs had developed on his left pigmented buttock. The other findings of Dowling–Degos disease were comedone-like lesions on the face and back, a finger-like fibroma in the right popliteal fossa, dystrophic fingernails, and a large number of seborrhoeic keratosis-like lesions predominantly on the flexural areas. Another unique clinical feature was the lack of vellus hair on the whole body surface. In addition to thin branching and elongation of rete ridges with basal hyperpigmentation, immature hair follicles surrounded by fibrosis and a lace-like pattern of the hair follicle epithelia were observed histologically. These epithelial hamartomatous features were consistent with Dowling–Degos disease. We speculate that the SCCs developed in relation to an underlying naevoid anomaly in pilosebaceous epithelia of Dowling–Degos disease.
The use of PVP as a polymeric carrier to improve the plasma half-life of drugs
Authors: Yoshihisa Kaneda, Yasuo Tsutsumi, Yasuo Yoshioka, Haruhiko Kamada, Yoko Yamamoto, Hiroshi Kodaira, Shin-ichi Tsunoda, Takayuki Okamoto, Yohei Mukai, Hiroko Shibata, Shinsaku Nakagawa, Tadanori Mayumi
Journal: Biomaterials (2003)
`A-Pin-Dicitis' and Liver Abscess
Authors: Michael K. Wood
Journal: JAMA (1981)

<h3>To the Editor.—</h3> Most foreign bodies, including sharp objects, are passed through the intestine without perforation.<sup>1</sup>Occasionally, they lead to fascinating clinical manifestations. <h3>Report of a Case.—</h3> An 18-month-old boy had been intermittently ill for nine months with diarrhea, malabsorption, growth retardation, and recent spiking fever. An alert pediatrician, after documenting fever, diarrhea, and an elevated WBC count and sedimentation rate, admitted the infant to the hospital. He was slightly irritable with a temperature of 38.1 °C and a pulse rate of 136 beats per minute. He was small for his age, with a weight equivalent to that of a 9-month-old infant. The remainder of the physical examination was unremarkable, including examination of the abdomen. The WBC count was 14,400/cu mm, with a normal differential cell count; the hemoglobin level was 9.6 g/dL; the results of a urinalysis were normal. Blood culture results and serum titers for ameba were
Cuts in legal aid will deter lawyers from taking on complex clinical negligence cases
Authors: C. Dyer
Journal: BMJ (2011)

The UK government is to go ahead with plans to scrap legal aid for clinical negligence cases in England and Wales, as part of a package to slash £350m (€390m; $560m) from the legal aid budget.

The justice secretary, Kenneth Clarke, announced the move after his department published the Legal Aid, Sentencing and Punishment of Offenders Bill, which will have its second reading debate on 29 June.

Mr Clarke said that anyone launching damages claims for clinical negligence would be expected in future to do so under a “no win, no …
463 Critical role of cysteine residues in human UGT1A1 in bilirubin glucuronidation
Authors: S GHOSH, S LEE, J ROYCHOWDHURY, N ROYCHOWDHURY
Journal: Hepatology (2003)

Crigler–Najjar type 1 disease (CN-1) is a genetic disorder characterized by high levels of unconjugated bilirubin due to the absence of hepatic UDPglucuronosyltransferase (UGT1) activity. Here we show that in vivo neonatal hepatocyte transduction with a lentiviral vector expressing the defective enzyme resulted in long-term correction in Gunn rats, a model of CN-1. Lentiviral vectors harboring the human UGT1 cDNA (approved symbol UGT1A1) under the control of a liver-specific transthyretin promoter were produced. Two-day-old Gunn rats were injected with 50 μl of vector. Bilirubinemia was monitored at 6 weeks and monthly thereafter. At 6 weeks, bilirubinemia was completely normalized in treated animals, whereas it remained around 100 μM in control rats. The level of correction remained stable for up to 42 weeks. Large amounts of bilirubin conjugates were present in the bile of corrected animals. PCR and Western blots confirmed the presence and expression of UGT1 in liver. The estimated proportion of transduced hepatocytes was 40% and transduced cells were not detected in extrahepatic tissues except bone marrow in some animals. This work represents the first demonstration of a complete and permanent correction of hyperbilirubinemia in Gunn rats using lentiviral vectors.
The Need for an Integrated Biopsychosocial Approach to Research on Successful Aging
Authors: Thomas S. Inui
Journal: Annals of Internal Medicine (2003)

Successful aging is defined not by longevity alone but also by sufficient well-being (in multiple domains) to sustain a capacity for functioning adequately in changing circumstances. The determinants of such well-being and functional status are manifold and include the genetic endowment, physical environment, social environment, population and individual responses to challenges, the occurrence of disease, availability and effectiveness of health care, and personal prosperity. In the face of such complexity, scientific approaches to the phenomena associated with successful aging should be appreciative and wholistic as well as reductionistic. Such a natural science of aging will be required to uncover and use information about linear, cause-and-effect phenomena, as well as about higher-order emergent patterns that are of relevance to the health of elderly persons, such as resilience and generativity. Taken as a whole, this multimethod research agenda will truly express an integrated biopsychosocial approach to research on successful aging.
UK healthcare system is one of most efficient in rich countries
Authors: A. Gulland
Journal: BMJ (2011)

Falls research and prevention efforts have traditionally focused on the very young and very old. But what about falls in young and middle-aged adults are they an issue? Do people suddenly stop falling when they become young adults and not start again till they reach advancing years? This presentation will focus on how common falls are in young and middle-age adults. The characteristics and contexts of falls in this age group will be discussed. Knowledge of factors that increase risks of having falls in this age group, and factors that predict poor outcome following falls will be presented. Finally opportunities for prevention will be debated including whether young and middle-aged adults think falls are a problem, what evidence is there that anything works, and where might future opportunities lie.
Therapeutic Milieu on Continuing Care Unit
Authors: LESLIE S. LIBOW
Journal: Annals of Internal Medicine (1971)

Letters and Comments1 April 1971Therapeutic Milieu on Continuing Care UnitLESLIE S. LIBOW, M.D., F.A.C.P., ROBERT M. VIOLA, M.D.LESLIE S. LIBOW, M.D., F.A.C.P.Search for more papers by this author, ROBERT M. VIOLA, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-74-4-638_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We were very pleased to read the article by Williams and colleagues, "The Use of a Therapeutic Milieu on a Continuing Care Unit in a General Hospital" (1), emphasizing the importance of making the milieu of the hospital ward an active therapeutic instrument. In October 1968 we published a description of such a unit, located at our acute general hospital, a major teaching division of the Mount Sinai School of Medicine (2). Williams and associates obviously had insufficient information in stating that "to the best of our knowledge, this method of unit organization has never been systematically...References1. WILLIAMS R, OVERLAN E, and RYZEWSKI J: The use of a therapeutic milieu on a continuing care unit in a general hospital. Ann Intern Med 73:957-962, 1970 LinkGoogle Scholar2. LIBOW L, VIOLA R, and STEIN M: The extended care facility at Mount Sinai City Hospital Center, Elmhurst, New York: three-year experience. J Amer Geriat Soc 16:1164-1172, 1968 CrossrefGoogle Scholar3. LIBOW L and MEHL B: Self-administration of medications by patients in hospitals or extended care facilities. J Amer Geriat Soc 18:81-85, 1970 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: LESLIE S. LIBOW, M.D., F.A.C.P.; ROBERT M. VIOLA, M.D.Affiliations: Department of Medicine Mount Sinai City Hospital Center at Elmhurst Elmhurst, N.Y. 11373 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1971Volume 74, Issue 4Page: 638-638KeywordsHospital medicineInformation technology ePublished: 1 December 2008 Issue Published: 1 April 1971 PDF downloadLoading ...
James Lyman Tullis
Authors: William V. McDermott
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An Illustrated Guide to Gastrointestinal Motility
Authors: A G Johnson
Journal: Gut (1994)

Selenium is an essential component of glutathione peroxidase, an enzyme that helps protect cells against oxidation damage and modulates the lipoxygenase pathway of arachidonic acid metabolism. Low selenium concentrations might therefore influence the inflammatory process in asthma by reducing the activity of glutathione peroxidase. Whole blood and plasma selenium concentrations and glutathione peroxidase activity have been measured in 56 asthmatic patients and 59 non-asthmatic control subjects in New Zealand, a country with a low dietary selenium intake and a high prevalence of asthma. When compared with control subjects the asthmatic patients had lower values for whole blood selenium concentrations (-4.9, 95% confidence interval -10.2 to 0.4 ng/ml) and glutathione peroxidase activity (-3.3, 95% CI -5.8 to -0.8 units/g Hb). There was a 1.9 and 5.8 fold increased risk of asthma in subjects with the lowest range of whole blood selenium concentration and glutathione peroxidase activity respectively (95% CI 0.6 to 5.6 and 1.6 to 21.2). Levels were lower in patients and control subjects without an atopic predisposition, but were not affected by prednisone use. Similar differences between the asthmatic and control subjects were not observed for selenium concentration or glutathione peroxidase activity measured in plasma, which reflects short term rather than long term selenium content. These findings are consistent with the hypothesis that low selenium concentrations may have a role in the pathogenesis of asthma in New Zealand.
Predictive value of the IL28B polymorphism on the effect of interferon therapy in chronic hepatitis C patients with genotypes 2a and 2b
Authors: Tomokazu Kawaoka, C. Nelson Hayes, Waka Ohishi, Hidenori Ochi, Toshiro Maekawa, Hiromi Abe, Masataka Tsuge, Fukiko Mitsui, Nobuhiko Hiraga, Michio Imamura, Shoichi Takahashi, Michaki Kubo, Tatsuhiko Tsunoda, Yusuke Nakamura, Hiromitsu Kumada, Kazuaki Chayama
Journal: Journal of Hepatology (2010)
Reports of Propoxyphene Dependence
Authors: Robert C. Wolfe
Journal: JAMA (1969)

To the Editor:—  In a case report by Salguero et al ( 210 :135, 1969) of propoxyphene dependence, the following statement is made: Almost no data that propoxyphene hydrochloride can produce drug dependence in man are available.  It is true that case reports are scanty. I should like to add one reference to those supplied by the authors.  Wolfe et al reported a case of propoxyphene addiction and withdrawal syndrome ( Ann Intern Med  70 :773, 1969) with an estimated daily intake of 2,300 mg. The patient was maintained in the hospital on a regimen of 1,300 mg daily. Abrupt discontinuance produced psychic and physical withdrawal syndrome.  It would appear that propoxyphene dependence is more frequent than published reports would indicate.
Tumor Cells Require Thymidylate Kinase to Prevent dUTP Incorporation during DNA Repair
Authors: Chun-Mei Hu, Ming-Tyng Yeh, Ning Tsao, Chih-Wei Chen, Quan-Ze Gao, Chia-Yun Chang, Ming-Hsiang Lee, Jim-Min Fang, Sheh-Yi Sheu, Chow-Jaw Lin, Mei-Chun Tseng, Yu-Ju Chen, Zee-Fen Chang
Journal: Cancer Cell (2012)
Moxonidine Normalizes Sympathetic Hyperactivity in Patients with Eprosartan-Treated Chronic Renal Failure
Authors: Jutta Neumann, Gerry Ligtenberg, Liam Oey, Hein A. Koomans, Peter J. Blankestijn
Journal: Journal of the American Society of Nephrology (2004)

Enalapril and losartan reduce but not normalize sympathetic hyperactivity in patients with hypertensive chronic renal failure (CRF). This study assessed the effect of chronic eprosartan on BP and sympathetic activity, and assessed the effect of moxonidine during chronic eprosartan treatment. In 11 stable patients with CRF (creatinine clearance 47 ± 10 ml/min), muscle sympathetic nerve activity (MSNA; peroneal nerve), BP, and baroreceptor sensitivity were measured in the absence of antihypertensive drugs (except diuretics) during chronic eprosartan therapy (600 mg for 6 wk) and in 9 patients after moxonidine (0.2 mg for 6 wk) was added. Normovolemia was controlled by diuretics and confirmed by extracellular fluid volume measurements. BP, heart rate, and MSNA were higher in patients than in 22 controls. During eprosartan therapy, mean arterial pressure (111 ± 9 to 98 ± 7 mmHg, P < 0.001), heart rate (71 ± 10 to 65 ± 8 bpm, P < 0.001), and MSNA (35 ± 10 to 27 ± 8 bursts/min, P < 0.001) decreased. After the addition of moxonidine (n = 9), a further reduction of mean arterial pressure to 89 ± 7 mmHg (P < 0.05) and of MSNA to 20 ± 10 bursts/min (P < 0.05) occurred. Sympathetic activity in patients with CRF can be normalized, and angiotensin II–independent sympathetic hyperactivity contributes to the pathogenesis of renal hypertension. Sympathetic hyperactivity is associated with poor cardiovascular outcomes, implying that reduction might be beneficial to the patients. The addition of moxonidine to angiotensin II antagonist treatment might be appropriate.
Atopic Dermatitis Associated with Eczema Herpeticum is Associated with Abnormal Expression of Keratin Genes in Skin Biopsies
Authors: D.N. Grigoryev, M.D. Howell, T.N. Watkins, C. Cheadle, M. Boguniewicz, K.C. Barnes, D.Y. Leung
Journal: Journal of Allergy and Clinical Immunology (2011)
The Psychological Basis of Medical Practice
Authors: Donald E. Widmann
Journal: JAMA (1963)

This book offers the nonpsychiatric physician a survey of the relationship between psychological insights and clinical medicine. The presentation is divided into three parts. There is an excellent preclinical section which discusses, among other things, evolution of the medical student into a physician and the growth of the patient-doctor relationship. Liberal use is made of contributions from the behavioral sciences and neurophysiology. The section devoted to the various clinical specialties includes summaries of classic articles in each field. Unfortunately there is no chapter dealing with neurological diseases. The section on treatment is organized about the role of the general practitioner in handling the emotional aspects of his patient's illness. The bibliographies are well chosen and offer suggestions for further reading. This reviewer was particularly impressed with the discussion of the psychological aspects of hospitalization and preparation for surgery. Though the material is not new, it is well presented. An unavoidable
Faster Electrophoretic Mobility of Albumin in Diabetes
Authors: Adrian O. Vladutiu
Journal: JAMA (1980)

To the Editor.—  Serum protein electrophoresis is an assay commonly performed in the majority of clinical laboratories. Our laboratory performs an average of 11,000 serum electrophoresis assays per year using plastic plates coated with a thin layer of agarose in barbital buffer (pH 8.6) and amido black 10B staining. I observed in about 0.3% of newly hospitalized patients that albumin moved more anodal in electrophoresis when compared with albumin of normal persons. However, the migration was much slower than that of prealbumin, ie, about 1 to 2 mm ahead of the normally migrating albumin. All of these patients had diabetes mellitus that was poorly controlled in more than 95% of them (eg, blood glucose concentration >180 mg/dL, glycosuria (3+) at admission regardless of previous or present treatment).  It was shown that albumin has a faster electrophoretic mobility in genetically diabetic mice. 1 Lately, it was reported that in certain conditions
SCALP syndrome: Sebaceous nevus syndrome, CNS malformations, aplasia cutis congenita, limbal dermoid, and pigmented nevus (giant congenital melanocytic nevus) with neurocutaneous melanosis: A distinct syndromic entity
Authors: Joseph Lam, Magdalene A. Dohil, Lawrence F. Eichenfield, Bari B. Cunningham
Journal: Journal of the American Academy of Dermatology (2008)
Comparison between Determination of Free Thyroxine Index and Effective Thyroxine Ratio in Human Serum
Authors: E. G. M. D'Haene, F. J. L. Crombag, J. F. W. Tertoolen
Journal: BMJ (1974)

Four thyroid function indices were determined in the sera of 181 patients: total thyroxine (T-4), the triiodothyronine resin uptake (T-3 B.C.-index), the free thyroxine (T-4) index, and the effective thyroxine ratio (E.T.R.). A statistically significant correlation between the free T-4 index and E.T.R. could be established though this correlation seemed to be worse than could be expected from the literature. Two sets of correlation coefficients were shown: one obtained with the ordinarily used Pearson or product-moment correlation and one with the Spearman rank correlation. Because the assumptions and requirements for the proper use of the product-moment correlation statistics, such as a normal distribution of both variables, are seldom met, expecially not if a selected number of controls and patients is used for the correlation, it is advisable to use some kind of rank correlation statistics instead. The advantages and disadvantages of the E.T.R. and free T-4 index determination are described.