tbuckley/cabot-search huggingface dataset:
Clinical and Hemodynamic Stability in a Patient With a Large Atrial Septal Defect
Authors: Barry M. Beller
Journal: JAMA (1966)

THE EVALUATION for corrective surgery of patients with congenital heart disease is based to a large extent on the clinician's knowledge of what is considered to be the natural history of the disease. In the case of left-to-right shunts, a decision to repair a given defect is based upon the size of the lesion as estimated from the magnitude of the shunt flow and the level of the pulmonary artery pressure. In addition, factors other than hemodynamic ones, such as the frequency of occurrence of bacterial endocarditis and the technical difficulty of doing the surgery, must be considered. For atrial septal defect, the accumulated literature<sup>1-3</sup>provides ample evidence that the average life expectancy for a child with this lesion is reduced. It has been noted that the larger the shunt is, the more cardiac disability or an inoperable situation is likely to develop. However, medical centers which have a
907-105 Selectin Blockade as an Adjunct to Thrombolytic Therapy Successfully Reduces Infarct Size Following Reperfusion in the Electrolytic Canine Coronary Artery Model
Authors: Mitchell J. Silver, Joseph M. Sutton, Sharon Hook, Philmo Lee, Stephen G. Ellis, Eric J. Topol, Francesca A. Nicolini
Journal: Journal of the American College of Cardiology (1995)
No Evidence of Transdifferentiation of Human Endothelial Progenitor Cells Into Cardiomyocytes After Coculture With Neonatal Rat Cardiomyocytes
Authors: Ina Gruh, Janina Beilner, Ulrike Blomer, Andreas Schmiedl, Ingrid Schmidt-Richter, Marie-Luise Kruse, Axel Haverich, Ulrich Martin
Journal: Circulation (2006)

Background— Recent studies have suggested the differentiation of human endothelial progenitor cells (huEPCs) isolated from peripheral blood into cardiomyocytes. This study investigates whether, when cocultured, neonatal rat cardiomyocytes (NRCMs) can induce transdifferentiation of huEPCs into cardiomyocytes. Methods and Results— Coculture experiments with 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindocarbocyanine (DiI)–labeled huEPCs and NRCMs have been performed. Cocultures have been analyzed by means of flow cytometry, 3D confocal laser microscopy, species-specific reverse transcriptase–polymerase chain reaction for the expression of human cardiac marker genes, and electron microscopy. Although fluorescence-activated cell sorting (FACS) analysis and conventional wide-field fluorescence microscopy suggested the existence of DiI pos cardiomyocytes in cocultures, no convincing evidence of cardiac differentiation of huEPCs has been obtained. Apparently, DiI pos cardiomyocytes were identified as necrotic NRCMs or NRCM-derived vesicles with high levels of autofluorescence or, alternatively, as NRCMs lying on top of or below labeled huEPCs or huEPC fragments. Accordingly, no expression of human Nkx2.5, GATA-4, or cardiac troponin I was detected. Conclusions— No convincing evidence of transdifferentiation of huEPCs into cardiomyocytes was obtained. Although we cannot exclude that recent contrary data may be due to slightly different culture protocols, our study has revealed that recently applied standard analysis tools including FACS and wide-field fluorescence microscopy are not sufficient to demonstrate transdifferentiation in coculture settings and can lead to misinterpretation of the data obtained solely with these methods.
Therapeutic Contact Lenses
Authors: William E. Smiddy, Tracey R. Hamburg, Gregory P. Kracher, John D. Gottsch, Walter J. Stark
Journal: Ophthalmology (1990)

Therapeutic contact lenses are useful in a variety of ocular surface disorders. Their efficacy was evaluated in 40 consecutive patients presenting for therapeutic contact lens fitting for pain due to depressed surface disorders (14 patients), raised surface disorders (11 patients), corneal decompensation (7 patients), trauma (5 patients), and disorders of corneal wetting (3 patients). The therapeutic contact lens was successfully fit and worn, with achievement of the therapeutic objective in 37 of the 40 patients. Corneal wetting disorders and corneal decompensation require only intermediate-term contact lens wear. Thus, therapeutic contact lenses are usually effective for relief of pain due to corneal surface disorders.
Liver biopsy: techniques, clinical applications, and complications.
Authors: J E Hegarty, R Williams
Journal: BMJ (1984)

<h3>Abstract</h3> We have developed pISA-tree, a straightforward and flexible data management solution for organisation of life science project-associated research data and metadata. It enables <i>on-the-fly</i> creation of enriched directory tree structure (project/Investigation/Study/Assay) via a series of sequential batch files in a standardised manner based on the ISA metadata framework. The system supports reproducible research and is in accordance with the Open Science initiative and FAIR principles. Compared with similar frameworks, it does not require any systems administration and maintenance as it can be run on a personal computer or network drive. It is complemented with two R packages, <i>pisar</i> and <i>seekr</i>, where the former facilitates integration of the pISA-tree datasets into bioinformatic pipelines and the latter enables synchronisation with the FAIRDOMHub public repository using the SEEK API. Source code and detailed documentation of pISA-tree and its supporting R packages are available from https://github.com/NIB-SI/pISA-tree.
Resistance profile of adefovir dipivoxil (ADV) in immunocompetent and immunocompromised chronic hepatitis B patients after 48 weeks of adefovir dipivoxil therapy
Authors: C.E. Westland, H. Yang, W.E. Delaney, V. Thibault, Y. Benhamou, C.S. Gibbs, M.D. Miller, M. Wulfsohn, M. Sullivan, J. Fry, C.L. Brosgart, S. Xiong
Journal: Journal of Hepatology (2003)
Recurrent respiratory papillomatosis (RRP): Disease severity associates with enhanced TH2-like dendritic cell chemokine (DC-CK1) plasma expression
Authors: D.W. Rosenthal, H. Schmidtmayerova, B.M. Steinberg, J.A. Devoti, L. Hatam, A. Vambutas, V.R. Bonagura
Journal: Journal of Allergy and Clinical Immunology (2005)
The Germ-Theory
Authors: D. W. Williams
Journal: BMJ (1871)

Late Physician to the West Norfolk and Lynn Hospital.PHYSIOLOGISTs and controversialists of justly distinguished eminence, both at home and abroad, have recentlv been engaged in the most abs- truse research relative to the solution of that difficult problem, the germ-theory," and as an inevitable sequence, "spontaneous genera - tion.
Prospective randomized trial of emergency portacaval shunt and emergency medical therapy in unselected cirrhotic patients with bleeding varices
Authors: Marshall J. Orloff, Richard H. Bell, Mark S. Orloff, William G.M. Hardison, Gerson A. Greenburg
Journal: Hepatology (1994)

A prospective randomized trial was conducted in unselected, consecutive patients with bleeding esophageal varices resulting from cirrhosis comparing (1) emergency portacaval shunt performed within 8 hr of initial contact (21 patients) with (2) emergency medical therapy (intravenous vasopressin and esophageal balloon tamponade) followed in 9 to 30 days by elective portacaval shunt in survivors (22 patients). All patients underwent the same diagnostic workup within 3 to 6 hr of initial contact, and received identical supportive therapy initially. All patients were followed up for at least 10 yr. The protocol contained no escape or crossover provisions. There were no statistically significant differences between the two treatment groups in the incidence of any of the clinical variables, results of laboratory tests or degree of portal hypertension. Child's risk classes in the shunt group were A—2 patients, B—8 patients and C—11 patients, whereas in the medical group they were A—10 patients, B—5 patients, and C—7 patients, a significant difference (p &lt; 0.01) that might have favored emergency medical treatment. Bleeding was controlled initially and permanently by emergency shunt in every patient, but by medical therapy in only 45% (p &lt; 0.001). Mean requirement for blood transfusion was 7.1 ± 2.6 units in the shunt group and 21.4 ± 2.6 units in the medical group (p &lt; 0.001). Eighty–one percent of the patients in the shunt group were discharged alive compared with 45% in the medical group (p = 0.027). Five– and 10–yr observed survival rates were 67% and 57%, respectively, after emergency shunt compared with 18% and 18%, respectively, after the combination of emergency medical therapy and elective shunt (p &lt; 0.01). These survival rates produced by emergency shunt performed within 8 hr of initial contact confirm the effectiveness of this procedure observed in our previous unrandomized studies. (Hepatology 1994;20:863-872).
Diagnosis of liver fibrosis and cirrhosis using liver stiffness measurement: Comparison between M and XL probe of FibroScan®
Authors: Victor de Lédinghen, Vincent Wai-Sun Wong, Julien Vergniol, Grace Lai-Hung Wong, Juliette Foucher, Shirley Ho-Ting Chu, Brigitte Le Bail, Paul Cheung-Lung Choi, Faiza Chermak, Karen Kar-Lum Yiu, Wassil Merrouche, Henry Lik-Yuen Chan
Journal: Journal of Hepatology (2011)
SATIRE
Authors: Theodore Kamholtz
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Immunologic Targets in Psoriasis
Authors: Thomas S. Kupper
Journal: New England Journal of Medicine (2003)

In this issue of the Journal, two reports present data on the efficacy of two new biologic drugs for psoriasis. One of these drugs, etanercept, has been used extensively in rheumatology and targets the pleiotropic inflammatory cytokine tumor necrosis factor α (TNF-α). The other, efalizumab, targets CD11a, or αL, one chain of αL β2 integrin, also known as leukocyte-function–associated antigen 1 (LFA-1); LFA-1 is important in the process by which T cells cross blood-vessel walls, enter tissue, and are subsequently activated by antigen. Increasingly, molecules that were once the exclusive domain of immunologic scientists have entered mainstream . . .
The retinoblastoma gene family pRb/p105, p107, pRb2/p130 and simian virus-40 large T-antigen in human mesotheliomas
Authors: Antonio De Luca, Alfonso Baldi, Vincenzo Esposito, Candace M. Howard, Luigi Bagella, Paoloa Rizzo, Mario Caputi, Harvey I. Pass, Giovan Giacomo Giordano, Feliciano Baldi, Michele Carbone, Antonio Giordano
Journal: Nature Medicine (1997)
Infantile Ophthalmia (Blennorrh a Neonatorum) and its Prevention
Authors: K. Grossmann
Journal: BMJ (1889)

the following month (September).There being an increase in the pain referred to the teeth, I asked my brother, William Hemrn, who was spending his holiday with me, to see the case, which he accordingly did, and discovered an exposed nerve in the second left upper bicuspid, and at once advised its removal, considering it the probable cause of the pain.The vision of the left eye was carefully tested late in September, and found to be 2, L. Tension+1 L.On October 5th the tooth was extracted, and sent direct to my brother for a report on its post-mortem condition, which I will give in his own words: "Ifpper second bicuspid of left side affected with a very large and deep carious cavity on its anterior surface, involving the pulp chamber, and a smaller and shallower one on its posterior surface.On splitting, the pulp was found to have been alive, its free surface ulcerating and covered with thin greenish pus, its deeper parts intensely red and injected; the pulp tissue altogether being in a state of great irritation, and a potential cause of much pain, both local and reflex."He also says: "I have seen several cases amongst my patients at the Dental and Middle- sex Hospitals of undoubted reflex ophthalmic disturbance due to dental caries, in which the lesion was less clearly marked than in this case.In a few cases which have been sent me from Moor- fields or from the out-patient ophthalmic department of my own hospital, an exposed pulp in some lurking position has most commonly been found to be the irritating cause."As to the progress of the case after the extraction of the tooth, the pain disappeared immediately and did not recur.For a fort- night the condition of the eye appeared to remain absolutely stationary, and then gradually the lesion gave in, and disappeared in from six to eight weeks, leaving a slight haziness of the cornea, with the usual thinning of the sclerotic, giving the blue coloration of the choroidal pigment over the seat of the sclerotitic patch.Tension in L. became e(qual to that of the R., and sight returned to the extent of -.HIaving given a fair trial to all the recognised methods of treat- ment before the extraction of the tooth, I at that time ceased to administer all internal remedies, and simply applied a solution of boracic acid locally.Although the post quod ergo propter quod is not a safe method of reasoning, yet the gradual spreading of the patch up to the time of the extraction of the tooth, the sudden check produced thereby, the gradual diminution, dating from a fortnight after the extraction, and, finally, the gradual return of the eye to its normal condition, point, I think, to the probability that in this case, at any rate, we have an example of an irritative lesion reflexly produced, in which the afferent nerve is the superior maxillary, or second division of the fifth nerve, and the effer entthe first division of the fifth and probably its nasal branch.
Effect of cetiedil, an in vitro antisickling agent, on erythrocyte membrane cation permeability.
Authors: L R Berkowitz, E P Orringer
Journal: Journal of Clinical Investigation (1981)

Cetiedil has been reported to relieve painful crises in sickle cell anemia and to have antisickling properties in vitro. The drug alters neither oxygen affinity nor the solubility of deoxyhemoglobin S. Because the viscosity of the erythrocyte interior and the kinetics of gelation are dependent on the concentration of hemoglobin, we postulated that cetiedil might inhibit sickling by modifying erythrocyte sodium or potassium movements in a manner that would increase cell water content and thus dilute the cell hemoglobin. The drug has two such effects: it inhibits the specific increase in potassium permeability that follows a rise in cytoplasmic calcium concentration and it causes a rise in passive sodium movements. These effects are further evidence that cell ion and water movements may be important in the process of sickling and suggest a mechanism for the results reported with cetiedil.
Woman sues for not being warned about psychological effects of abortion
Authors: C. Dyer
Journal: BMJ (2002)

A woman who had an abortion four years ago announced last week that she was applying for legal aid to sue the NHS for the psychological trauma she claims to have experienced in the aftermath.

The unnamed 28 year old nurse from the north of England, who works in the NHS, sobbed as she told her story on BBC Radio 4's Today programme. She said she began to experience guilt and self hatred after she had a son two and a half years …
Essays on the Rise and Decline of Bedside Medicine
Authors: Jacalyn Duffin
Journal: JAMA (1989)

It is generally agreed that doctors now spend less time with their patients than in the past. The single author of this collection of essays addresses this issue by noting that the information explosion of the 20th century, coupled with the increasing threat of litigation, has placed pressure on physicians to choose between the "bedside" and the "lab." Clearly, he thinks they have made the wrong choice and his dismay over the exaggerated importance of the lab has inspired him to write. Insights offered by senior members of the profession can provide valuable clinical philosophy. The author, who has made a number of contributions to pathophysiology, claims that the strongest critics of laboratory medicine are those who have mastered and rejected it. A "strong critic" himself, then, he is no stranger to the telling of cautionary tales. Like a latter-day Cassandra, in a series of recent columns for<i>Chest</i>he
Handbook of Diseases of Aging
Authors: C. Anderson Hedberg
Journal: JAMA (1984)

Dr Herman Blumenthal emphasizes in his introduction that this volume is not about the basic biology of aging or clinical geriatrics. It is about disease causality as possibly directly related to biologic aging. As such, it is a provocative and brilliant multiauthored volume containing a wealth of research and theoretical information on the relationship between aging and disease.  Dr Blumenthal hypothesizes that the aging process, at a molecular level, represents an accumulation over time of errors in intracellular information flow, with transcription and translation mistakes, resulting in the production of misspecified proteins. These cybernetic alterations result in cellular dysfunctions, which combine with environmental risk factors to produce a high incidence of certain diseases in the elderly (cancer, arteriosclerosis, autoimmune diseases, diabetes mellitus, hypertension, and Alzheimer's disease). Twenty-five prominent investigators thoroughly discuss these pathological states, not so much from the viewpoint of proving this hypothesis, but instead to provide an objective
Clinical and pathologic features of obstructive disease in the predominant right and left coronary circulations in man.
Authors: R J Boucek, R Romanelli, W H Willis, W A Mitchell
Journal: Circulation (1980)

The clinical features and the location and severity of obstructive coronary artery disease are contrasted in 98 patients with predominant left and 99 patients with predominant right coronary circulations. A significantly higher incidence of ventricular conduction disturbances and a greater incidence and severity of obstructive coronary artery disease (greater than or equal to 70% cross-sectional narrowing in the proximal left anterior descending, circumflex and right coronary arteries and their major branches) distinguish the predominant left from the predominant right coronary circulation. The results suggest an anatomically disadvantaged status for the predominant left compared with the predominant right coronary circulations with respect to ventricular conduction disturbances and to coronary atherogenesis in man.
Intrajugular Vein Delivery of AAV9-RNAi Prevents Neuropathological Changes and Weight Loss in Huntington's Disease Mice
Authors: Brett D Dufour, Catherine A Smith, Randall L Clark, Timothy R Walker, Jodi L McBride
Journal: Molecular Therapy (2014)

Huntington's disease (HD) is a fatal neurological disorder caused by a CAG repeat expansion in the HTT gene, which encodes a mutant huntingtin protein (mHTT). The mutation confers a toxic gain of function on huntingtin, leading to widespread neurodegeneration and inclusion formation in many brain regions. Although the hallmark symptom of HD is hyperkinesia stemming from striatal degeneration, several other brain regions are affected which cause psychiatric, cognitive, and metabolic symptoms. Additionally, mHTT expression in peripheral tissue is associated with skeletal muscle atrophy, cardiac failure, weight loss, and diabetes. We, and others, have demonstrated a prevention of motor symptoms in HD mice following direct striatal injection of adeno-associated viral vector (AAV) serotype 1 encoding an RNA interference (RNAi) construct targeting mutant HTT mRNA (mHTT). Here, we expand these efforts and demonstrate that an intrajugular vein injection of AAV serotype 9 (AAV9) expressing a mutant HTT-specific RNAi construct significantly reduced mHTT expression in multiple brain regions and peripheral tissues affected in HD. Correspondingly, this approach prevented atrophy and inclusion formation in key brain regions as well as the severe weight loss germane to HD transgenic mice. These results demonstrate that systemic delivery of AAV9-RNAi may provide more widespread clinical benefit for patients suffering from HD.
Medical and Biological Research in Israel
Authors: George Halperin
Journal: JAMA (1961)

The publishers of this volume emphasize the importance of scientific research for a country small in size and poor in natural resources. The Hebrew University and the Hadassah Association hoped in sponsoring this volume that it would serve not only as a guide to what has been accomplished, but even more so to what remains to be done. Their achievements, they feel, have been modest. The investigations described have been carried out for the most part during the brief period of Israel's statehood. What is important, however, is that an atmosphere conducive to scientific investigation has been created. Emphasis is placed on both fundamental and applied research. The volume is divided into 2 sections, one describing research of a regional and applied nature in the fields of public health and social medicine and the other dealing with fundamental studies such as experimental biology, research in medical disciplines, botany, and zoology.
Cancer of the Urogenital Tract: Wilms' Tumor and Neuroblastoma
Authors: Philip Rubin
Journal: JAMA (1968)

The term "neuroblastoma" is an umbrella covering a variety of histologic types of tumor which arise from cells in the neural crest to form the sympathetic ganglia and the adrenal medulla. The primitive cell is the sympathicogonioma and differentiates along two lines as shown in the modified diagram by Karsner<sup>1</sup>(Introductory Figure). This series of communications is concerned with those tumors of sympathetic nervous tissue origin: sympathicogonioma, sympathicoblastoma, and ganglioneuroma. It is important to note that the more malignant tumor which tends to arise in the infant and younger child is the sympathicogonioma; the sympathicoblastoma is more highly differentiated and less malignant when it occurs in later life. The ganglioneuroma is usually a benign tumor; it tends to occur in older children (over 10 years of age) and rarely metastasizes. The key to understanding the changing attitude toward treatment in this malignancy lies in the evolution of the highly