Acute Pancreatitis Associated with Celecoxib
Authors: Anne M. Baciewicz, Denise R. Sokos, Thomas J. King
Journal: Annals of Internal Medicine (2000)

Letters18 April 2000Acute Pancreatitis Associated with CelecoxibAnne M. Baciewicz, PharmD, MBA, Denise R. Sokos, PharmD, and Thomas J. King, MDAnne M. Baciewicz, PharmD, MBAUniversity Hospitals of Cleveland; Cleveland, OH 44106 (Baciewicz)University Hospitals of Cleveland; Cleveland, OH 44106 (Sokos)Case Western Reserve University; South Euclid, OH 44121 (King), Denise R. Sokos, PharmDUniversity Hospitals of Cleveland; Cleveland, OH 44106 (Baciewicz)University Hospitals of Cleveland; Cleveland, OH 44106 (Sokos)Case Western Reserve University; South Euclid, OH 44121 (King), and Thomas J. King, MDUniversity Hospitals of Cleveland; Cleveland, OH 44106 (Baciewicz)University Hospitals of Cleveland; Cleveland, OH 44106 (Sokos)Case Western Reserve University; South Euclid, OH 44121 (King)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-8-200004180-00027 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We report a case of possible acute pancreatitis associated with the cyclooxygenase-2 inhibitor celecoxib. An 81-year-old man presented with a 2-day history of right upper quadrant pain that began 48 hours after initiation of therapy with celecoxib, 200 mg/d.The patient's medical history included nephrostomy tubes, chronic renal insufficiency, peripheral neuropathy, hypothyroidism, Paget disease, anemia, gastrointestinal bleeding due to arteriovenous malformations, and osteoarthritis. The patient had undergone cholecystectomy. Long-term medical therapy included carbamazepine, double-strength trimethoprim-sulfamethoxazole DS, enteric coated aspirin, 1,25 dihydroxycholecalciferol, and l-thyroxine.On admission, vital signs were normal. Laboratory values showed a leukocyte count of 12.6 ...References1. Goldstein J, Laskin DA, Ginsberg GH. Sulindac associated with pancreatitis [Letter]. Ann Intern Med. 1980;93:151. LinkGoogle Scholar2. DuVille L, Debeuckelaere S, Reynaert H, Devis G. Pancreatitis associated with naproxen. Am J Gastroenterol. 1993;88:464. Google Scholar3. Goyal SB, Goyal RS. Ketorolac tromethamine-induced acute pancreatitis [Letter]. Arch Intern Med. 1998;158:411. CrossrefMedlineGoogle Scholar4. Wilmink T, Frick TW. Drug-induced pancreatitis. Drug Saf. 1996;14:406-23. CrossrefMedlineGoogle Scholar5. Celebrex package insert. Skokie, IL: Searle Pfizer; 1999. Google Scholar Author, Article, and Disclosure InformationAffiliations: University Hospitals of Cleveland; Cleveland, OH 44106 (Baciewicz)University Hospitals of Cleveland; Cleveland, OH 44106 (Sokos)Case Western Reserve University; South Euclid, OH 44121 (King) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDrug induced pancreatitis: A systematic review of case reports to determine potential drug associationsUse of Celecoxib Correlates With Increased Relative Risk of Acute Pancreatitis: A Case–Control Study in TaiwanNSAIDs and Acute Pancreatitis: A Systematic ReviewMetformin-induced lactic acidosis and acute pancreatitis precipitated by diuretic, celecoxib, and candesartan-associated acute kidney dysfunctionPharmacological approach to acute pancreatitisNewer cyclo-oxygenase-2 selective inhibitors, other non-steroidal anti-inflammatory drugs and the risk of acute pancreatitisAcute pancreatitis: a rare complication of celecoxibCyclooxygenase-2 gene disruption attenuates the severity of acute pancreatitis and pancreatitis-associated lung injuryAcute pancreatitis associated with rofecoxibNew drug therapies for the pediatric rheumatic diseasesCelecoxib: a new option in the treatment of arthropathies and familial adenomatous polyposisCelecoxib 18 April 2000Volume 132, Issue 8Page: 680KeywordsAcute pancreatitisCalciumDrugsLipasesPancreatitisPeripheral neuropathyResearch laboratoriesSulfonamideThyroxineVital signs Issue Published: 18 April 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...