tbuckley/cabot-search huggingface dataset:
Empyema after internal jugular catheterisation in rheumatoid arthritis.
Authors: V B Antony, S A Sahn
Journal: Thorax (1981)

Violation of the pleural space is a known complication of percutaneous central venous catheterisation.Pneumothorax, hydrothorax, and haemothoraxl have been re- ported after internal jugular vein catheterisation.We were asked to see a patient with rheumatoid arthritis who developed an insidious staphylococcal empyema as a complication of jugular venous catheterisation. Case reportA 67-year-old white man with rheumatoid arthritis was admitted to hospital for aortic valve replacement and coronary artery bypass.Medications included indo- methacin, digoxin, and frusemide.A right internal jugular catheter was inserted on the day of operation and re- moved on the fourth postoperative day without apparent complications.The patient's postoperative course was ...
Odd-Looking Hair and Progressive Alopecia in Mother and Son
Authors: Annette Kolb-Mäurer, Regina C. Betz, Henning Hamm
Journal: JAMA Dermatology (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Mental Illness in General Health Care: An International Study
Authors: R. Morriss
Journal: BMJ (1995)

Ed T B Ustun, N Sartorius Wiley for WHO, £50, pp 398 ISBN 0 471 95491 8

How do mental disorders in primary care vary in terms of frequency, nature, and treatment across the world? Mental Illness in General Health Care describes a prospective study, sponsored by the World Health Organisation, of cultural differences in mental disorders in primary care involving 15 centres in five continents. The topic should interest general practitioners, psychiatrists, and public health doctors. The book itself is clearly written and easy to follow. After …
The Third Global Forum: framing the health workforce agenda for universal health coverage
Authors: Giorgio Cometto, Ties Boerma, James Campbell, Lola Dare, Tim Evans
Journal: The Lancet Global Health (2013)

The 2006 World Health Report recognised that adequate human resources for health are needed to accelerate progress and sustain achievements in the context of the MDGs, and called for a decade of action on human resources for health: the launch of the Global Health Workforce Alliance (GHWA), the convening of two global forums on human resources for health (in 2008 and 2011), and the introduction in 2010 by the World Health Assembly of the WHO Global Code of Practice on International Recruitment of Health Personnel are among the key milestones of this period, having bolstered political attention to human resources for health. As leaders worldwide embrace the broader aspiration of universal health coverage “based on an adequate, skilled, well-trained and motivated workforce”, a forward-looking human resources for health agenda to which countries and other stakeholders can commit and that is tailored to achieving this objective needs to be outlined. Universal health coverage, a key component of the post-2015 development agenda,15 needs comprehensive health services that are responsive to people’s needs to address the full range of promotion, prevention, treatment, rehabilitation, and palliation services. Given the centrality of the health workforce in this agenda, human resources for health commitments announced at the Forum will also serve as foundations for future collaboration and mutual accountability to accelerate progress towards the attainment, and sustainability ofuniversal health coverage.
Effect of streptozotocin-induced diabetes on GLUT-4 phosphorylation in rat adipocytes.
Authors: N Begum, B Draznin
Journal: Journal of Clinical Investigation (1992)

We have examined the regulation of GLUT-4 phosphorylation in adipocytes isolated from diabetic rats. Despite progressive (40-70%) reductions in GLUT-4 protein contents on the 2nd, 7th, and 14th day of diabetes, the phosphorylation of GLUT-4 was increased two- to fourfold. These alterations were accompanied by concomitant reductions (40-66%) in the insulin-stimulated 2-deoxyglucose transport. Insulin treatment of diabetic animals for 5 d restored glucose transport activity, GLUT-4 protein, and GLUT-4 phosphorylation to control levels whereas vanadate and phlorizin were ineffective. In control adipocytes, insulin promoted GLUT-4 translocation from the low density microsomal (LDM) pool to the plasma membranes (PM) and decreased the state of GLUT-4 phosphorylation. In adipocytes isolated from the diabetic rats, insulin failed to stimulate GLUT-4 translocation and to decrease GLUT-4 phosphorylation. To explore the mechanism of the diabetes-induced increases in the GLUT-4 phosphorylation, we investigated phosphoserine phosphatase (PSPase) activities using 32P-labeled GLUT-4 and phosphorylase "a" as substrates. Diabetes resulted in 50-60% increase in the particulate PSPase activity and concomitant reductions in cytosolic PSPase activities. Although reduced cytosolic PSPase activity correlated with an inadequate dephosphorylation of LDM GLUT-4, the existence of highly phosphorylated PM GLUT-4 in the presence of increased particulate PSPase activity required additional explanation. To address this problem, we used PM GLUT-4 from diabetic rats as a substrate of particulate PSPase. Highly active diabetic particulate PSPase, which dephosphorylated control GLUT-4 and phosphorylase a, failed to dephosphorylate PM GLUT-4 from diabetic rats. These data suggest that PM GLUT-4 from diabetic rats is unable to interact with PSPase or that its phosphorylation sites are not accessible to PSPase action. In summary, an induction of diabetes with streptozotocin resulted in significant increases in GLUT-4 phosphorylation. In contrast to normal cells, insulin failed to promote GLUT-4 recruitment to the plasma membranes and its dephosphorylation in diabetic adipocytes. At the same time, diabetes appears to induce redistribution of PSPases, resulting in lower cytosolic activity and higher particulate activity. It also appears that the existence of highly phosphorylated GLUT-4 in the plasma membranes of diabetic adipocytes resulted from its inability to interact with particulate PSPases.
Cost-effectiveness of capsule endoscopy in screening for colorectal cancer
Authors: C. Hassan, A. Zullo, S. Winn, S. Morini
Journal: Endoscopy (2008)

See also: Commentaire de travail de C. Hassan et al., pp. 414Endoscopy 2008; 40(05): 455-456DOI: 10.1055/s-0032-1306834
Are cysteine-rich and COOH-terminal domains of dystrophin critical for sarcolemmal localization?
Authors: D Récan, P Chafey, F Leturcq, J P Hugnot, N Vincent, F Tomé, H Collin, D Simon, P Czernichow, L V Nicholson
Journal: Journal of Clinical Investigation (1992)

It has been hypothesized that the tight localization of dystrophin at the muscle membrane is carried out by its cysteine-rich and/or carboxyl domains. We report the results of biochemical and immunocytochemical investigations of dystrophin in muscle from a 1-yr-old patient with a large deletion that removes the distal part of the dystrophin gene, thus spanning the exons coding for the cysteine-rich and the carboxy-terminal domains, and extends beyond the glycerol kinase and congenital adrenal hypoplasia genes. Immunological analysis of muscle dystrophin shows that the deletion results in the production of a truncated, but stable, polypeptide correctly localized at the sarcolemma. These data indicate that neither the cysteine-rich domain, nor the carboxyl domain, are necessary for the appearance of normal dystrophin sarcolemmal localization.
Abstract P1-08-13: Predictive value of intrinsic luminal subtypes in premenopausal women with endocrine-responsive early breast cancer: Results from Austrian breast and colorectal cancer study group trial 5
Authors: Z Bago-Horvath, M Rudas, R Jakesz, R Greil, O Dietze, C Suppan, S Lax, CF Singer, M Filipits, M Gnant
Journal: Cancer Research (2013)

Abstract Purpose: The aim of the present study was to assess the predictive value of intrinsic luminal subtypes in premenopausal hormone receptor-positive early breast cancer patients who received adjuvant endocrine treatment or chemotherapy. Patients and Methods: Intrinsic luminal breast cancer subtypes were centrally assessed by immunohistochemistry on whole tissue sections of breast cancer patients who had been enrolled in the Austrian Breast and Colorectal Cancer Study Group (ABCSG) Trial 5 and received either 3 years of goserelin plus 5 years of tamoxifen or six cycles of cyclophosphamide, methotrexate, and fluorouracil (CMF). Luminal A disease was defined as Ki67 &amp;lt;20%, Luminal B/HER2-negative subtype as Ki67≥20%. Luminal B/HER2-positive subtype displayed HER2 overexpression by IHC or amplification by ISH. Recurrence-free survival (RFS) and overall survival (OS) were analyzed using Cox models adjusted for clinical and pathological factors. Results: 155 (36%), 217 (50%) and 59 (14%) of 431 tumors were classified as Luminal A, Luminal B/HER2-negative and Luminal B/HER2-positive, respectively. Luminal B subtypes were associated with poor outcome. Patients with Luminal B tumors had a significantly shorter RFS (adjusted hazard ratio [HR] for recurrence: 2.29, 95% confidence interval [CI] 1.44-3.64, P &amp;lt; 0.001) and OS (adjusted HR for death: 3.97, 95% CI 1.94-8.08, P &amp;lt; 0.001) as compared to patients with Luminal A disease. No interaction between intrinsic luminal subtypes and treatment was observed (test for interaction: P = 0.42 for RFS; P = 0.32 for OS). Combination endocrine treatment with goserelin/tamoxifen tended to be more effective than CMF chemotherapy in both luminal A and luminal B subtypes. Conclusion: Intrinsic luminal subtype is an independent prognostic factor for recurrence and death in premenopausal women with early-stage, hormone receptor positive breast cancer but is not predictive for outcome of adjuvant treatment with either goserelin/tamoxifen or chemotherapy with CMF. Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P1-08-13.
Derivation of Insulin Producing Cells From Human Endometrial Stromal Stem Cells and Use in the Treatment of Murine Diabetes
Authors: Xavier Santamaria, Efi E Massasa, Yuzhe Feng, Erin Wolff, Hugh S Taylor
Journal: Molecular Therapy (2011)

Pancreatic islet cell transplantation is an effective approach to treat type 1 diabetes, however the shortage of cadaveric donors and limitations due to rejection require alternative solutions. Multipotent cells derived from the uterine endometrium have the ability to differentiate into mesodermal and ectodermal cellular lineages, suggesting the existence of mesenchymal stem cells in this tissue. We differentiated human endometrial stromal stem cells (ESSC) into insulin secreting cells using a simple and nontransfection protocol. An in vitro protocol was developed and evaluated by assessing the expression of pan β-cell markers, followed by confirmation of insulin secretion. PAX4, PDX1, GLUT2, and insulin, were all increased in differentiated cells compared to controls. Differentiated cells secreted insulin in a glucose responsive manner. In a murine model, differentiated cells were injected into the kidney capsules of diabetic mice and human insulin identified in serum. Within 5 weeks blood glucose levels were stabilized in animals transplanted with differentiated cells, however those treated with undifferentiated cells developed progressive hyperglycemia. Mice transplanted with control cells lost weight and developed cataracts while those receiving insulin producing cells did not. Endometrium provides an easily accessible, renewable, and immunologically identical source of stem cells with potential therapeutic applications in diabetes.
Measles elimination--why not now?
Authors: J. B. Richmond
Journal: JAMA (1979)

So many disorders—bronchitis, bronchogenic carcinoma, ischemic heart disease, peripheral vascular disease, male infertility, osteoporosis, even impaired fetal growth—point their fingers at cigarette smoking as a culprit, or an accomplice, that one cannot help but feel self-conscious when commenting on yet more accusing fingers. Metaphoric digits turn, as it were, into feet that kick someone who is already down. Still, one is constrained to mention two disorders in which smoking has been recently implicated: malignant-phase hypertension and subarachnoid hemorrhage. Comparing the smoking habits of 48 sufferers from malignant hypertension with those of 92 nonmalignant hypertensive patients, Bloxham et al<sup>1</sup>noted that 68.75% of the former group and 36.96% of the latter were smokers when their conditions were first diagnosed. Even though the sample was small and the two groups are not strictly comparable—the first were consecutive admissions to hospital in six years, the second attended an outpatient clinic at the
Applicants for senior medical positions in New Zealand
Authors: A. J Ekeroma
Journal: BMJ (1995)

referrals may well have reversed since 1991 because of the NHS reforms, which have seen so many radical changes in both general practice and the hospital sector.Until more up to date national data are available, Armstrong and Nicoll's argument, which is based on historical trends, may not be applicable.In addition, our figures show a small decrease in the number of patients followed up during the period.This is contrary to Armstrong and Nicoll's suggestion that the problem of recycling patients has become worse in recent years and has resulted in access for new outpatient referrals being blocked.
Case 15-1970
Authors: Richard C. Cabot, Benjamin Castleman, Betty U. McNeely, Maurice B. Straus, Robert E. Scully
Journal: New England Journal of Medicine (1970)

Presentation of Case First admission. A thirty-eight-year-old man was admitted to the hospital because of uremia.At the age of fourteen years he had been studied at another hospital because of "kidney trouble"; an intravenous pyelographic study revealed dilatation of the left collecting system and a calyceal filling defect, and a retrograde pyelographic study demonstrated bilateral ureteral angulations. Subsequently, he failed the Armed Services induction examination because of proteinuria. Eighteen months before entry there was the onset of fatigue, malaise and joint swelling, interpreted by a physician as "gouty arthritis." One year later weakness, pallor, dyspnea and ankle edema . . .
Infection in Lymphoma
Authors: Albert R. Casazza
Journal: JAMA (1966)

Infections occur frequently in patients with lymphomas.<sup>1-3</sup>Recurrent staphylococcal infections, gram-negative septicemia, and fungal and viral complications are all relatively more common in patients with hematological malignancies.<sup>4-7</sup> Altered immunological reactivity,<sup>3,8,9</sup>chemotherapy,<sup>5</sup>and corticosteroid therapy<sup>6,10-12</sup>have all been implicated as predisposing factors to infection in these patients. However, no report has correlated these factors and the development of infections with disease duration. Moreover, few studies have analyzed for comparison a group of patients without clinical infection. This report defines and compares the incidence of the types of infections occurring in patients with Hodgkin's disease, mycosis fungoides, lymphosarcoma, and reticulum cell sarcoma. The development of infections was related to the duration of the patients illness. <h3>Materials and Methods</h3> The autopsy and clinical records of all patients with Hodgkin's disease, lymphosarcoma, reticulum cell sarcoma, and mycosis fungoides dying at the National Institutes of Health during the years 1953
Marketing in the lay media and prescriptions of terbinafine in primary care: Dutch cohort study
Authors: Geert W ‘t Jong, Bruno H Ch Stricker, Miriam C J M Sturkenboom
Journal: BMJ (2004)

In May 2000 in the Netherlands, the manufacturer of terbinafine, Novartis, started a nationwide “information campaign” which included television advertisements advising people with onychomycosis to visit their general practitioner. The Dutch Society of General Practitioners objected to this campaign as an unnecessary focus on an unimportant health problem.1 In the Netherlands, terbinafine and itraconazole are available as oral treatments for onychomycosis, but the Society's guidelines recommend terbinafine.2 3 In May 2002, a Dutch court decided that Novartis's campaign did not violate laws prohibiting advertising of prescription drugs as neither Novartis nor terbinafine were specifically named1; however, Novartis stopped the campaign in July 2002. We studied the changes in rates of prescriptions of oral terbinafine and itraconazole and the consultation rate before and after the start of the campaign.

We retrieved all …
Radiologic Notes in Cardiology
Authors: MURRAY G. BARON
Journal: Circulation (1971)

The diagnosis of a dissecting aneurysm can be suggested by the clinical findings or plain films of the chest but a definitive diagnosis cannot be made without angiography. Selective aortography is the procedure of choice as it provides the maximum amount of information at a relatively low risk. Important diagnostic findings include a double lumen within the aorta, separation of the opacified channels by a linear lucency, absence of filling of one or more major branches of the abdominal aorta, or a thickening of the aortic wall when there is no flow in the false channel. Because of the seriousness of the lesion, once the diagnosis of a dissecting aneurysm is suggested, aortography should be performed with a minimum of delay.
The cytochromes P450 and mechanisms of chemical carcinogenesis.
Authors: D V Parke
Journal: Environmental Health Perspectives (1994)

This article reviews mechanisms of chemical carcinogenesis, from metabolic activation and generation of reactive oxygen species by cytochromes P4511 and P4502E to DNA damage, activation of protein kinase C and ocogenes, hyperplasia, and proteoglycan changes in the cell glycocalyx and lysosomal enzymes which mediate invasion and metastasis.
Pain and Public Policy
Authors: Richard A. Deyo
Journal: New England Journal of Medicine (2000)

Some physicians, patients, and policy makers conceive of illness in purely biologic terms. According to this view, social, economic, and legal forces are irrelevant to symptoms and behavior; only tissue injury and healing matter. However, in this issue of the Journal, Cassidy and his colleagues report that changes in a tort system of compensation for traffic injuries can dramatically change the numbers and duration of insurance claims for whiplash injury.1 This finding, along with similar observations in other studies, suggests that external factors have an important influence on the behavior of patients that is independent of biologic factors. Though . . .
17-Ketosteroid and 17-hydroxycorticosteroid excretion in patients with duodenal ulceration
Authors: A. G. Green, C. N. Pulvertaft
Journal: Gut (1962)

The 24-hour excretion of 17-ketosteroids and 17-hydroxycorticosteroids has been estimated in a series of male duodenal ulcer subjects and compared with that of 56 normal male controls. It has been found that both 17-ketosteroid and 17-hydroxycorticosteroid excretion is less in ulcer subjects than in the control group; these differences are not large but in the case of 17-hydroxycorticosteroids they are statistically significant. For active ulcers (107 men) 17-hydroxycorticosteroid excretion is approximately 78% of normal and 17-ketosteroid excretion 93% of normal; in the quiescent phase (50 men) the differences are rather larger, being respectively 71% and 86% of normal. This reduced excretion persists after operation in both the short term, six months after operation (53 men), and the long term, 10 years and more after gastric resection (39 men).
Amoxicillin-clavulanic acid versus cefotaxime in the therapy of bacterial infections in cirrhotic patients
Authors: Elena Ricart, Germán Soriano, Maria Teresa Novella, Jordi Ortiz, Míriam Sàbat, Lylian Kolle, Javier Sola-Vera, Josep Miñana, Josep Maria Dedéu, Cristina Gómez, José L Barrio, Carlos Guarner
Journal: Journal of Hepatology (2000)
p38α Inhibits Liver Fibrogenesis and Consequent Hepatocarcinogenesis by Curtailing Accumulation of Reactive Oxygen Species
Authors: Toshiharu Sakurai, Masatoshi Kudo, Atsushi Umemura, Guobin He, Ahmed M. Elsharkawy, Ekihiro Seki, Michael Karin
Journal: Cancer Research (2012)

Most hepatocellular carcinomas (HCC) develop in the context of severe liver fibrosis and cirrhosis caused by chronic liver inflammation, which also results in accumulation of reactive oxygen species (ROS). In this study, we examined whether the stress-activated protein kinase p38α (Mapk14) controls ROS metabolism and development of fibrosis and cancer in mice given thioacetamide to induce chronic liver injury. Liver-specific p38α ablation was found to enhance ROS accumulation, which appears to be exerted through the reduced expression of antioxidant protein HSP25 (Hspb1), a mouse homolog of HSP27. Its reexpression in p38α-deficient liver prevents ROS accumulation and thioacetamide-induced fibrosis. p38α deficiency increased expression of SOX2, a marker for cancer stem cells and the liver oncoproteins c-Jun (Jun) and Gankyrin (Psmd10) and led to enhanced thioacetamide-induced hepatocarcinogenesis. The upregulation of SOX2 and c-Jun was prevented by administration of the antioxidant butylated hydroxyanisole. Intriguingly, the risk of human HCC recurrence is positively correlated with ROS accumulation in liver. Thus, p38α and its target HSP25/HSP27 appear to play a conserved and critical hepatoprotective function by curtailing ROS accumulation in liver parenchymal cells engaged in oxidative metabolism of exogenous chemicals. Augmented oxidative stress of liver parenchymal cells may explain the close relationship between liver fibrosis and hepatocarcinogenesis.
Kent private finance initiative scheme will not save money
Authors: A. Kemp
Journal: BMJ (1999)

The National Audit Office has warned that the new Dartford and Gravesham Hospital in Kent, to be built under the private finance initiative (PFI) scheme, may prove more expensive than it would be under traditional methods.

The report on the £177m ($283m) contract signed in 1997, tried to look on the bright side but was “quietly damning”. The trust hoped that the scheme would save £17m ($26.5m) against public procurement, but the true figure of only £5m means that, …