tbuckley/cabot-search huggingface dataset:
F-18 FDG PET/CT Following Dental Extraction in a Patient With Head and Neck Cancer
Authors: Bohdan Bybel
Journal: Clinical Nuclear Medicine (2007)

A 48-year-old man with squamous-cell carcinoma of the left tonsillar fossa and cervical lymph node metastases was being staged before radiation and chemotherapy. The patient had periodontal disease, and extraction of 2 teeth was performed before therapy. A staging PET/CT was performed 1 week after extraction. This case demonstrates increased FDG uptake at the extraction sites, which could be potentially mistaken for metastatic lesions, especially without the fused PET/CT images.
Expression of an endothelial-type nitric oxide synthase isoform in human neutrophils: modification by tumor necrosis factor-alpha and during acute myocardial infarction
Authors: Trinidad de Frutos, Lourdes Sánchez de Miguel, Jerónimo Farré, Juan Gómez, José Romero, Pedro Marcos-Alberca, Antonio Nuñez, Luis Rico, Antonio López-Farré
Journal: Journal of the American College of Cardiology (2001)
A Single-Subunit NADH-Quinone Oxidoreductase Renders Resistance to Mammalian Nerve Cells against Complex I Inhibition
Authors: Byoung Boo Seo, Eiko Nakamaru-Ogiso, Terence R. Flotte, Takao Yagi, Akemi Matsuno-Yagi
Journal: Molecular Therapy (2002)

Numerous studies suggest that dysfunction of mitochondrial proton-translocating NADH-ubiquinone oxidoreductase (complex I) is associated with neurodegenerative disorders, such as Parkinson's disease and Huntington's disease. Development of methods to correct complex I defects seems important. We have previously shown that the single-subunit NADH dehydrogenase of Saccharomyces cerevisiae (Ndi1P) can work as a replacement for complex I in mammalian cells. Using a recombinant adeno-associated virus vector carrying the NDI1 gene, we now demonstrated that the Ndi1 enzyme was successfully expressed in the dopaminergic cell lines rat PC12 and mouse MN9D. The cells expressing the Ndi1 protein were resistant to known inhibitors of complex I, such as rotenone and pyridaben. In addition, the NDI1-transduced cells were still capable of morphological maturation as examined by induction of neurite outgrowth. Also, it was possible to infect the cells after the maturation. The expressed Ndi1 protein was located both in cell bodies and in neurites and was functionally active. It is conceivable that the NDI1 gene will be a promising tool in the treatment of neurodegenerative conditions caused by complex I inhibition. Numerous studies suggest that dysfunction of mitochondrial proton-translocating NADH-ubiquinone oxidoreductase (complex I) is associated with neurodegenerative disorders, such as Parkinson's disease and Huntington's disease. Development of methods to correct complex I defects seems important. We have previously shown that the single-subunit NADH dehydrogenase of Saccharomyces cerevisiae (Ndi1P) can work as a replacement for complex I in mammalian cells. Using a recombinant adeno-associated virus vector carrying the NDI1 gene, we now demonstrated that the Ndi1 enzyme was successfully expressed in the dopaminergic cell lines rat PC12 and mouse MN9D. The cells expressing the Ndi1 protein were resistant to known inhibitors of complex I, such as rotenone and pyridaben. In addition, the NDI1-transduced cells were still capable of morphological maturation as examined by induction of neurite outgrowth. Also, it was possible to infect the cells after the maturation. The expressed Ndi1 protein was located both in cell bodies and in neurites and was functionally active. It is conceivable that the NDI1 gene will be a promising tool in the treatment of neurodegenerative conditions caused by complex I inhibition.
Histological evaluation of alpha 2a interferon monotherapy in patients with chronic hepatitis C and repeatedly normal aminotransferase levels. A randomized study
Authors: C. Hézode, F. Roudot-Thoraval, D. Capron, S. Naveau, G.H. Riachi, P. Chaumet-Riffaut, M.P. Bralet, E.S. Zafrani, J.M. Pawlotsky, D. Dhumeaux
Journal: Journal of Hepatology (2001)
Effects of sevelamer treatment on cardiovascular abnormalities in mice with chronic renal failure
Authors: Julien Maizel, Isabelle Six, Sebastien Dupont, Edouard Secq, Benedicte Dehedin, Fellype C. Barreto, Joyce Benchitrit, Sabrina Poirot, Michel Slama, Christophe Tribouilloy, Gabriel Choukroun, Jean C. Mazière, Tilman B. Drueke, Ziad A. Massy
Journal: Kidney International (2013)
The Antisuicide Pill
Authors: David Lester
Journal: JAMA (1969)

To the Editor:—  There has been much discussion recently of the possible deleterious effects from oral contraceptives on the health of women using them 1 (for example, thrombophlebitis 2 ). It is rare to find anyone postulating a beneficial effect from oral contraceptives.  Mackinnon, et al 3 reported that successful attempts at suicide by women reached a peak during the midluteal phase of the menstrual cycle. (Unsuccessful attempts reach a peak during the premenstrual and menstrual phases of the cycle. 4 ) It is not known yet what the causes of the association are and no one has yet speculated about possible causes. However, whether the cause-and-effect relationship (if one exists) is due to the direct influence of hormonal levels or via mediation through psychological mood-states, it would seem that the alteration of the menstrual process by the use of oral contraceptives might have an effect on the successful suicide rate of
From Conventional to Atypical Antipsychotics and Back: Dynamic Processes in the Diffusion of New Medications
Authors: Douglas L. Leslie, Robert A. Rosenheck
Journal: American Journal of Psychiatry (2002)

Between 1994 and 1997, the Food and Drug Administration approved three new atypical antipsychotic medications for the treatment of schizophrenia. The authors tracked prescription patterns for these medications, an atypical antipsychotic approved in 1989, and conventional neuroleptics in the Department of Veterans Affairs (VA) to determine how the new drugs have diffused in a national health care system.Pharmacy claims data were collected for all patients with a diagnosis of schizophrenia in the VA. Patients who received stable 3-month prescriptions of any antipsychotic medication were followed over fiscal year 2000 to determine how often they were switched to another drug, how much time elapsed before they were switched, the drug to which they were switched, and whether they subsequently switched back to the original drug.Of the 21,873 patients with schizophrenia who had stable 3-month prescriptions of any antipsychotic medication, 5,426 (25%) had their medications switched during the next year. Half of these patients (N=2,708) switched back to their original drug, usually within 30 days. Patients who had stable prescriptions of clozapine were the least likely to be switched (18%), and patients who had stable prescriptions of quetiapine were the most likely to be switched (37%). When medications were switched, 35% of the patients were switched to olanzapine; only 1% were switched to clozapine, and only 14% were switched to quetiapine.Pharmacotherapy for schizophrenia is a dynamic process. One-quarter of patients with stable antipsychotic drug regimens had their medication changed within 1 year. Quetiapine was the least prescribed of the newer drugs. These results suggest that it is important that all of these medications are included in formularies.
A piece of my mind. Predator and prey
Authors: L. J. Purdy
Journal: JAMA (1990)

The day after the shooting, I woke to the sound of mockingbirds and blue jays. While sipping coffee and reading the newspaper in the quiet of my morning, I took a moment to gaze at the panorama of the Pomona Valley and the chaparralcovered hills to the west. When the sun turned the hillside golden, I began to see deer grazing. Hummingbirds, already at work, were darting among the flowers of a blossoming century plant. From my breakfast window, when the valley is clear, I can see the hospital in the distance. Life is much different down there. There are no glimpses of deer or chatter of birds. The newspaper articles I read are about as close as I ever get to the people who live near my hospital. My job as pathologist, however, delivers me and my presumed good fortune into a restless discomfort with the violent and unnecessary
ON RUPTURE OF THE INNER CIRCLE OF THE IRIS
Authors: W. W. Cooper
Journal: BMJ (1855)

s Hospital, etc. DETACHMENT of the iris from its ciliary border is a com- mon result of external violence; but there is an injury occasionally caused by heavy blows upon the eye, which, with its consequences, are but slightly mentioned by the ma4ority of ophthalmic writers.Il many systematic works it is passed over altogether.I allude to rupture of the inner margm of the ins, gring rise to wide and persistent dilatation of the pupil and serious disturbance of vision.The following cases afford illustrations of this severe accident:-CASE I.In October 1854, a man was admitted into St.Mary's Hospital, having received a very severe blow upon the right eye; the anterior chamber was full of blood, and no trace of the iris was visible.He was put to bed, and cold applications were ordered to be constantly applied to the injured eye; a brisk aperient was administered, and he was placed on low regimen.
GASTROSPLENIO VARICES, A PITFALL TO AVOID IN EVALUATING LOWER GASTROINTESTINAL BLEEDING
Authors: Ian A. Weissman, Lorraine M. Fig, Charles S. Mam, Milton D. Gross
Journal: Clinical Nuclear Medicine (1995)

Weissman, Ian A.; Fig, Lorraine M.; Mam, Charles S.; Gross, Milton D. Author Information
LONG–TERM CLINICAL OUTCOMES AFTER INTRACORONARY IMPLANTATIONS OF SIROLIMUS– AND PACLITAXEL–ELUTING STENTS
Authors: Dong–Ho Shin, Jung–Sun Kim, Byeong–Keuk Kim, Young–Guk Ko, Bum–Kee Hong, Donghoon Choi, Myeong–Ki Hong, Hyuck Moon Kwon, Yangsoo Jang
Journal: Journal of the American College of Cardiology (2013)
In Vivo Effectiveness of a High-Yield Factor VIII Concentrate Prepared in a Blood Bank
Authors: G. Rock, R. K. Smiley, P. Tittley, D. S. Palmer
Journal: New England Journal of Medicine (1984)

1YOPHILIZED factor VIII concentrates have beJ come the treatment of choice for factor VIII-deficient patients with hemophilia. The cost of such treatment is high, primarily because under normal conditions of collection and preparation, factor VIII procoagulant activity (VIIIC, sec Table 1 for terms and definitions1) is unstable and as much as 80 per cent of the activity is lost during the purification procedure. Recently, we have reported that factor VIIIC activity is stabilized when blood is collected into heparin rather than citrate anticoagulant, and we have shown that the cryoprecipitates obtained from heparinized blood contain 80 per cent of the VIIIC . . .
A method for the continuous calculation of the age of labeled red blood cells
Authors: Christopher J. Lindsell, Robert S. Franco, Eric P. Smith, Clinton H. Joiner, Robert M. Cohen
Journal: American Journal of Hematology (2008)

New methods for labeling red blood cells (RBC) and monitoring their survival have made it possible to explore changes in the properties of RBC as they age in the circulation. We have adapted a method, originally developed for studying wild animals, to calculate the age of a random sample of labeled RBC from their survival curve. We also show how this method can be expanded to allow continuous calculation of the mean age of the labeled RBC population at any time after labeling. It is expected that this analytical approach will be useful in the study of age-dependent RBC changes.
PROGNOSTIC VALUE OF PLASMA BRAIN NATRIURETIC PEPTIDE LEVELS RESPONSE DURING EXERCISE IN ASYMPTOMATIC PATIENTS WITH AORTIC STENOSIS
Authors: Romain Capoulade, Julien Magne, Raluca Dulgheru, Zeineb Hachicha, Jean Dumesnil, Kim O'Connor, Marie Arsenault, Sébastien Bergeron, Luc Pierard, Patrizio Lancellotti, Philippe Pibarot
Journal: Journal of the American College of Cardiology (2013)
Glycemic Control in the Intensive Care Unit
Authors: Cesar Alaniz, Robert C. Hyzy
Journal: Annals of Internal Medicine (2010)

Letters5 January 2010Glycemic Control in the Intensive Care UnitCesar Alaniz, PharmD and Robert C. Hyzy, MDCesar Alaniz, PharmDFrom University of Michigan Health System, Ann Arbor, MI 48109.Search for more papers by this author and Robert C. Hyzy, MDFrom University of Michigan Health System, Ann Arbor, MI 48109.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-152-1-201001050-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We would like to clarify one aspect of Comi's (1) commentary on glucose control in the intensive care unit and amplify another. First, although the NICE-SUGAR (Normoglycaemia in Intensive Care Evaluation and Survival Using Glucose Algorithm Regulation) (2) control group was stated to have a target glucose level less than 10.0 mmol/L (<180 mg/dL), it was actually much less than that, because insulin infusions were continued until the blood glucose level reached 8.0 mmol/L (144 mg/dL). Indeed, the time-weighted mean blood glucose level in the control group was 8.0 mmol/L (144 mg/dL). Data on the mean glucose ...References1. Comi RJ. Glucose control in the intensive care unit: a roller coaster ride or a swinging pendulum? Ann Intern Med. 2009;150:809-11. [PMID: 19487715] LinkGoogle Scholar2. Finfer S, Chittock DR, Su SY, Blair D, Foster D, Dhingra V, et al; NICE-SUGAR Study Investigators. Intensive versus conventional glucose control in critically ill patients. N Engl J Med. 2009;360:1283-97. [PMID: 19318384] CrossrefMedlineGoogle Scholar3. Davis SN, Mann S, Galassetti P, Neill RA, Tate D, Ertl AC, et al. Effects of differing durations of antecedent hypoglycemia on counterregulatory responses to subsequent hypoglycemia in normal humans. Diabetes. 2000;49:1897-903. [PMID: 11078457] CrossrefMedlineGoogle Scholar4. Dotson S, Freeman R, Failing HJ, Adler GK. Hypoglycemia increases serum interleukin-6 levels in healthy men and women. Diabetes Care. 2008;31:1222-3. [PMID: 18332163] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Cesar Alaniz, PharmD; Robert C. Hyzy, MDAffiliations: From University of Michigan Health System, Ann Arbor, MI 48109.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoGlucose Control in the Intensive Care Unit: A Roller Coaster Ride or a Swinging Pendulum? Richard J. Comi Metrics 5 January 2010Volume 152, Issue 1Page: 65-66KeywordsBloodConflicts of interestCortisolGlucoseHealth statisticsHypoglycemiaHypoglycemicsInsulinIntensive care unitsMedical intensive care units ePublished: 5 January 2010 Issue Published: 5 January 2010 Copyright & PermissionsCopyright © 2010 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Changes in Monosaccharide Content of Mucous Glycoproteins in Ulcerative Colitis
Authors: R. H. Teague, D. Fraser, J. R. Clamp
Journal: BMJ (1973)

Colonic mucus appears to consist of two glycoprotein fractions, one of which contains mannose, whereas the other is mannose-free. The mannose-containing fraction is significantly increased in ulcerative colitis.
Silent Brain Infarction and Platelet Activation in Obstructive Sleep Apnea
Authors: Kenji Minoguchi, Takuya Yokoe, Toshiyuki Tazaki, Hideko Minoguchi, Naruhito Oda, Akihiko Tanaka, Mayumi Yamamoto, Shin Ohta, Christopher P. O'Donnell, Mitsuru Adachi
Journal: American Journal of Respiratory and Critical Care Medicine (2007)

Silent brain infarction (SBI) and increased levels of soluble CD40 ligand (sCD40L) and soluble P-selectin (sP-selectin) are associated with an increased risk of cerebrovascular disease.The aim of this study was to evaluate whether SBI and serum levels of sCD40L and sP-selectin are increased in patients with obstructive sleep apnea (OSA).SBI was studied by brain magnetic resonance images in 50 male patients with OSA and 15 obese male control subjects who were free of comorbidities. In addition, the effects of 3 months of treatment with nasal continuous positive airway pressure (nCPAP) on serum parameters were studied in 24 patients with moderate to severe OSA.The percentage of SBI in patients with moderate to severe OSA (25.0%) was higher than that of obese control subjects (6.7%) or patients with mild OSA (7.7%). Serum levels of sCD40L and sP-selectin were significantly higher in patients with moderate to severe OSA than in obese control subjects (p < 0.05) or patients with mild OSA (p < 0.05). In addition, nCPAP significantly decreased serum levels of sCD40L (p < 0.03) and sP-selectin (p < 0.01) in patients with moderate to severe OSA.These results suggest that serum levels of sCD40L and sP-selectin are elevated and SBI is more common in patients with moderate to severe OSA, leading to elevated cerebrovascular morbidity. Moreover, nCPAP may be useful for decreasing risk in patients with moderate to severe OSA.
The Myth of the Workforce Crisis. Why the United States Does Not Need More Intensivist Physicians
Authors: Jeremy M. Kahn, Gordon D. Rubenfeld
Journal: American Journal of Respiratory and Critical Care Medicine (2014)

Intensivist physician staffing is associated with lower mortality in the intensive care unit (ICU), yet many ICUs are not staffed by trained intensivists. This gap has led to a number of proposals intended to increase the intensivist supply in the United States. In this perspective we argue that such efforts would be both ineffective and ill-advised. Because many ICU patients are not critically ill, workforce models that base demand projections on ICU admission rather than true critical illness substantially overstate the workforce gap. Even in the presence of a workforce gap, training new intensivists would not place them in hospitals where they are needed most, would not mitigate the shortage of nonphysician critical care providers, and would require a unrealistic increase in spending on physician training. In addition, efforts to train more intensivists require us to prioritize intensive care over other specialties that are also in short supply, without clear justification for why intensivists are more important. Rather than continuing an unwarranted push to increase the intensivist supply, we suggest alternative workforce policies that emphasize novel interprofessional care models (to improve ICU quality in the absence of intensivists) combined with limitations on the future growth of ICU beds (to reduce demand through implicit rationing of care). These policies offer opportunities to reduce the mismatch between critical care supply and demand without an unnecessary expansion of the intensivist supply.
Saul Genuth, MD: Clinical Researcher and Leader in Developing Modern Diabetes Treatment
Authors: Alan M. Jacobson, David M. Nathan
Journal: Diabetes Care (2015)

Saul Genuth was born to David L. and Anna Einhorn Genuth on 13 March 1931 in Norwalk, Connecticut. His father was an orthodox rabbi and his mother was a housewife. David Genuth was born and raised in Hungary but immigrated to the U.S. to escape induction into the Romanian army (the area of Hungary where he lived ceded to Romania after World War I). Anna’s parents came from Poland, seeking a better life for their future family. David became an orthodox rabbi, while Anna remained a homemaker and a rabbi’s wife (which Saul states was a profession in and of itself).



Saul Genuth, MD



Saul was 4 years old when his family moved to Cleveland, Ohio, and he has made Cleveland his home through most of his medical training and his entire professional career. Saul noted that he and his two younger sisters grew up “somewhat poor in a lower middle class neighborhood but were never hungry or deprived.” He remains close to his one surviving sister, a retired attorney in Portland, Maine. When asked about his childhood, he admits he was not the athletic type growing up but could shoot a mean game of marbles. Today his main source of recreation is reading. Saul’s subtle sense of humor comes through as he explains, “I hope printed books never disappear. I don’t read e-books, they have never ‘kindled’ my interest.” He is also devoted to classical music and regularly attends Cleveland Orchestra concerts and local recitals.

Saul met Molly Goodman, the love of his life, in 7th grade. He told the story of them sitting near each other in homeroom because their last names both began with “G.” They became fast friends, and as a 13-year-old, Molly told her mother that one day she was going to marry Saul Genuth. …
CROSS-REACTIONS TO SKIN HOMOGRAFTS IN MAN*
Authors: F. T. Rapaport, H. S. Lawrence, L. Thomas, J. M. Converse, W. S. Tillett, J. H. Mulholland
Journal: Journal of Clinical Investigation (1962)

A considerable array of evidence has been se- cured to suggest that the tempo and intensity of the host's immune response to tissue transplants are conditioned by the degree of histocompatibility existing between the individuals studied (1-4).Although this subject has received a great deal of attention in animal species, it has not been studied extensively in man (5-7).The present report is concerned with the infl- enice of genetic disparity upon the fate of skin homografts in man.The results of a 9-year study of 147 skin homografts performed in a group of unrelated normal subjects are presented and dis- cussed in the light of observed variations in the individual specificity of the rejection reaction. MATERIALS AND METHODSSelection of skin homograft donors and recipients.The subj ects were students and house officers of the Third and Fourth Medical and Surgical Divisions (New York University) at Bellevue Hospital, New York.The donors were individuals known not to transmit se- rum hepatitis on the basis of their previous record of skin or blood donations at Bellevue Hospital.Technique of grafting and of graft observation.The skin specimens were removed from the donors under 1 per cent procaine local anesthesia, and anchored to the host bed with 5-0 interrupted nylon sutures.The grafts were full-thickness specimens 11 mm in diameter.They were placed on the anterior surface of the forearm of the recipient.Pressure dressings were applied and changed 2 days later.On the fourth day, they were replaced by Band-aids.
Unmutated Immunoglobulin M Can Protect Mice from Death by Influenza Virus Infection
Authors: Yuichi Harada, Masamichi Muramatsu, Toshikatsu Shibata, Tasuku Honjo, Kazumichi Kuroda
Journal: The Journal of Experimental Medicine (2003)

To elucidate the role of class switch recombination (CSR) and somatic hypermutation (SHM) in virus infection, we have investigated the influence of the primary and secondary infections of influenza virus on mice deficient of activation-induced cytidine deaminase (AID), which is absolutely required for CSR and SHM. In the primary infection, AID deficiency caused no significant difference in mortality but did cause difference in morbidity. In the secondary infection with a lethal dose of influenza virus, both AID−/− and AID+/− mice survived completely. However, AID−/− mice could not completely block replication of the virus and their body weights decreased severely whereas AID+/− mice showed almost complete prevention from the reinfection. Depletion of CD8+ T cells by administration of an anti-CD8 monoclonal antibody caused slightly severer body weight loss but did not alter the survival rate of AID−/− mice in secondary infection. These results indicate that unmutated immunoglobulin (Ig)M alone is capable of protecting mice from death upon primary and secondary infections. Because the titers of virus-neutralizing antibodies were comparable between AID−/− and AID+/− mice at the time of the secondary infection, a defect of AID−/− mice in protection of morbidity might be due to the absence of either other Ig classes such as IgG, high affinity antibodies with SHM, or both.