tbuckley/cabot-search huggingface dataset:
p53 Activation in Response to Mitotic Spindle Damage Requires Signaling via BubR1-Mediated Phosphorylation
Authors: Geun-Hyoung Ha, Kwan-Hyuck Baek, Hyun-Soo Kim, Sook-Jung Jeong, Chang-Min Kim, Frank McKeon, Chang-Woo Lee
Journal: Cancer Research (2007)

Abstract The mitotic spindle checkpoint plays a crucial role in regulating accurate chromosome segregation and preventing the adaptation of multiploid progeny cells. Recent reports have indicated that the induction of p53 by mitotic checkpoint activation is essential for protecting cells from abnormal chromosome ploidization caused by mitotic failure. However, although studies have shown that p53 deficiencies arrest mitosis, compromise apoptosis, and may cause profound aneuploidy, the molecular mechanisms leading to p53 induction following mitotic checkpoint activation remain unknown. Here, we show that the BubR1 mitotic checkpoint kinase interacts with p53 both in vitro and in vivo, with higher levels of interaction in mitotic cells. This interaction contributes to p53 phosphorylation. Silencing of BubR1 expression reduces the phosphorylation and stability of p53, whereas exogenous introduction of BubR1 proteins into BubR1-depleted cells recovers p53 stability. In addition, inhibition of BubR1 expression in the presence of a microtubule inhibitor accelerates chromosomal instability and polyploidy in p53-null cells. These results collectively suggest that p53 activation in response to mitotic spindle damage requires signaling via BubR1-mediated phosphorylation. [Cancer Res 2007;67(15):7155–64]
The nature of hemispheric specialization in man
Authors: J. L. Bradshaw, N. C. Nettleton
Journal: Behavioral and Brain Sciences (1981)

Abstract The traditional verbal/nonverbal dichotomy is inadequate for completely describing cerebral lateralization. Musical functions are not necessarily mediated by the right hemisphere; evidence for a specialist left-hemisphere mechanism dedicated to the encoded speech signal is weakening, and the right hemisphere possesses considerable comprehensional powers. Right-hemisphere processing is often said to be characterized by holistic or gestalt apprehension, and face recognition may be mediated by this hemisphere partly because of these powers, partly because of the right hemisphere's involvement in emotional affect, and possibly through the hypothesized existence of a specialist face processor or processors in the right. The latter hypothesis may, however, suffer the same fate as the one relating to a specialist encodedness processor for speech in the left. Verbal processing is largely the province of the left because of this hemisphere's possession of sequential, analytic, time-dependent mechanisms. Other distinctions (e.g., focal/diffuse and serial/parallel) are special cases of an analytic/holistic dichotomy. More fundamentally, however, the left hemisphere is characterized by its mediation of discriminations involving duration, temporal order, sequencing, and rhythm, at the sensory (tactual, visual, and, above all, auditory) level, and especially at the motor level (for fingers, limbs, and, above all, the speech apparatus). Spatial aspects characterize the right, the mapping of exteroceptive body space, and the positions of fingers, limbs, and perhaps articulators, with respect to actual and target positions. Thus there is a continuum of function between the hemispheres, rather than a rigid dichotomy, the differences being quantitative rather than qualitative, of degree rather than of kind.
Yoga for bronchial asthma
Authors: R Nagarathna
Journal: BMJ (1985)

Inefficient clinic systems leading to prolonged wait times at primary care clinics are a source of frustration for patients, physicians, staff and administration. Measuring and shortening cycle time has the potential to improve patient experience, staff satisfaction and patient access by moving more patients through in a shorter cycle time. Limited studies have demonstrated that improvements can be made to cycle time and may result in improved patient satisfaction. Most of these studies have focused their efforts on improving efficiency at the front end of the cycle. Our aim was to improve cycle time for the whole visit to less than 60 min within 1 year by engaging our team in brainstorming solutions, presenting regular measurements to our team for review and holding regular meetings to plan rapid improvement cycles. Over the course of 1 year (2017), we were able to reduce cycle time by 12% from 71 to 65 min and to improve patient satisfaction with care. Despite the reduction in cycle time, we maintained high satisfaction scores from patients who felt that the doctor spent enough time with them. We learnt the value of engaging our team, frequent measurement for reporting, adequate staffing at the beginning of clinic, and the value of MA staff acting in a flow coordinator role. We have not only maintained this improvement but also made further small gains over the subsequent 2 years, and by April 2019, our cycle time is at 60 min, despite a marked increase in patient volume. Additional work on the time after the patient is roomed and waiting for a doctor, and further analysis of the physician workflow would be important next steps to drive further improvement.
Association of Elevated B-Type Natriuretic Peptide Levels With Angiographic Findings Among Patients With Unstable Angina and Non-ST-Segment Elevation Myocardial Infarction
Authors: Saihari Sadanandan, Christopher P. Cannon, Kasi Chekuri, Sabina A. Murphy, Peter M. DiBattiste, David A. Morrow, James A. de Lemos, Eugene Braunwald, C. Michael Gibson
Journal: Journal of the American College of Cardiology (2004)
THE TEACHER WHO INFLUENCED ME
Authors: A. Abrahams
Journal: BMJ (1996)

It is 1956. The limousine draws up before the portico of Guy's Hospital and out steps Dr Arthur Henry Douthwaite, senior physician to Guy's Hospital, in full morning dress and bowler hat. Waiting to greet him at the top of the steps are the sister, senior registrar, junior registrar, senior house physician, assistant house physician, senior students on the firm, and junior students—one of them me.

We proceed to the ward gravely and by the time we reach …
What Is Psychotherapy of Psychosis?
Authors: G. Benedetti
Journal: Psychotherapy and Psychosomatics (1974)

This topic would have been too ambitious, had it not been the subject of the congress: 'what is psychotherapy?' Our contribution will be merely a basis for discussing and summarizing the experiences of myself and my colleagues through 20 years. I will stress the following main points: (1) The structure of the Therapeutic Relationship. The therapeutic relationship in the psychotherapy of schizophrenic patients is the result of our counter-identification with them and of our readiness to take upon ourselves the burden of their psychotic existence. (2) The structure of Interpretation and Resistance Transference. Interpretations of psychotic experiences do not primarily, as in neurosis, have the function of making the unconscious conscious, but that of organizing the split part (the delusion, the hallucination) into a whole, formed, first of all, by the two persons participating in the process. (3) The structure of Resistance and Regression in Treatment. The major condition which the patient lays upon us in order to communicate with us is that we accept reaching him within his symptoms. They are like necessary channels through which we can approach him, while at the same time protecting his tiny mode of being. The analysis has a special unburdening and ego-strengthening character, because the therapist identifies with the patient's earlier narcissistic traumas and helps him to express them in normal conceptions. In this type of therapy the unconscious of the therapist plays a greater role than in therapy of neurotics. His activity includes therapeutic phantasies and dreams about the patient.
Correction: Effects of Acyclovir and Meperidine
Authors: Lawrence Corey, John Douglas
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 March 1986Correction: Effects of Acyclovir and MeperidineLAWRENCE COREY, M.D., JOHN DOUGLAS, M.D.LAWRENCE COREY, M.D.Search for more papers by this author, JOHN DOUGLAS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-104-3-449_4 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Two errors appeared in our letter in the December issue (1). The last two sentences of the fourth paragraph should read: "Tremors, myoclonus, seizures, and depressed consciousness have been associated with the use of meperidine in patients with renal insufficiency, presumably due to the accumulation of the metabolite normeperidine (5, 6). When adjusted for likely predialysis values, the normeperidine levels seen in our patient are within the range of those seen in patients with cancer with meperidine-related central nervous system toxicity (6)." The correct designation of the last author is Harvey Krasny, Ph.D., Burroughs Wellcome Co., Research...1. JOHNSONDOUGLASCOREYKRASNEY RJLH. Adverse effects with acyclovir and meperidine [Letter]. Ann Intern Med. 1985;103:962-3. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: LAWRENCE COREY, M.D.; JOHN DOUGLAS, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1986Volume 104, Issue 3Page: 449-450KeywordsCentral nervous systemConsciousnessEpileptic seizuresMetabolitesMyoclonusToxicity ePublished: 1 December 2008 Issue Published: 1 March 1986 PDF downloadLoading ...
Angiotensin receptor blockers and risk of myocardial infarction: systematic review
Authors: Michael A McDonald, Scot H Simpson, Justin A Ezekowitz, Gabor Gyenes, Ross T Tsuyuki
Journal: BMJ (2005)

<h3>Abstract</h3> <b>Objective</b> To evaluate the effect of angiotensin receptor blockers on the risk of myocardial infarction in patients at risk for cardiovascular events. <b>Design</b> Systematic review of controlled trials of angiotensin receptor blockers. <b>Data sources</b> Medline, Embase, Cochrane central register of controlled trials, hand search, and contact with investigators. <b>Selection of studies</b> Predefined criteria were used to select controlled clinical trials comparing use of angiotensin receptor blockers with angiotensin converting enzyme (ACE) inhibitors or placebo in patients at risk for cardiovascular events. Data were extracted for patients9 characteristics, interventions, quality of trials, and rates of myocardial infarction. <b>Results</b> 19 studies with 31 569 patients were included in the analysis. Two studies investigated the use of angiotensin receptor blockers in hypertensive patients, four studies in patients with diabetes and nephropathy, 10 studies in patients with heart failure, and three in patients with recent myocardial infarction or ischaemic syndrome. 11 studies of 21 062 patients allowed for comparison between angiotensin receptor blockers and placebo; nine studies of 10 625 patients allowed for comparison between angiotensin receptor blockers and ACE inhibitors. Use of angiotensin receptor blockers was not associated with increased risk of myocardial infarction compared with placebo (odds ratio 0.94, 95% confidence interval 0.75 to 1.16) nor with increased risk of myocardial infarction compared with ACE inhibitors (1.01, 0.87 to 1.16). <b>Conclusions</b> Treatment with angiotensin receptor blockers was not associated with a significantly increased risk of myocardial infarction. The 95% confidence intervals do, however, not exclude an increase of up to 16% in the risk of myocardial infarction or a reduction in risk of up to 25%. Until further information specifically dealing with this issue is available from large prospective trials, our findings may alleviate recent concerns over the safety of this class of medications.
Weight of the Brain at Different Periods of Life
Authors: T. B. Peacock
Journal: BMJ (1851)

lIN the year 1846, I communcated to the Edinburgh Monthly JTournal of Medical Science a series of observations of the Weight of the Brain and other organs of the body, together with various tables, compiled from the whole of the observations collected by the late Professor John Rcid1 and myself, while holdig the office of Pathologist to the Royal Infirmary of Edinburgh.Since this time I have made the following observations, which, though comparatively few in number, yet being complete as to the weilghts of the brain and its several parts, and cor- respondig in every respect with the two previous series of observations collectedl by Professor Reid and myself, may form an useful addition to them.The present series contains also several weights of the Brain in young persons, in which the former were especially deficient.The weight employed, I need scarcely add, is avoirdupois.TABLE I. wErIGHT OF THE BRAIN IN MALES.The D in the column " Heart" indicates that the organ was diseased.Weight of the Cereb.
Feature see, feature do
Authors: Philip J. Benson
Journal: Behavioral and Brain Sciences (1998)

Physiological evidence predicts a model of concept categorisation that evolves through direct interaction with object feature selection. The requirement stated by Schyns et al. for feature plasticity is supported, but important caveats raise a question about the level at which feature identification can occur. Visual attribute selection for feature creation is likely to be directed by top-down and attentional processes.
THE PROBABLE NATURE OF THE INFECTIOUS AGENT OF TRACHOMA
Authors: L. A. Julianelle, R. W. Harrison, M. C. Morris
Journal: The Journal of Experimental Medicine (1937)

1. The infectious agent of trachoma can be freed from extraneous bacteria by passage through rabbit testicle. 2. The infectious agent multiplies little, if at all, during such passage, but in many instances retains its infectivity undiminished. 3. No specific changes occur in the rabbit testicle incidentally to the passage. 4. On rare occasion the trachoma agent may be freed from bacteria by intracerebral passage. The brain tissues show no specific reaction. 5. Filtration experiments with Seitz, Kramer, Berkefeld, and Elford filters confirm the general observation that the infectious agent is filterable with difficulty. 6. Tissue culture experiments, with tissues containing the infectious agent (conjunctiva, rabbit testicle, brain, etc.), conducted under a wide variety of conditions, proved uniformly unsuccessful in the cultivation of the agent. 7. The agent is inactivated by bile, AgNO(3), phenol, cocaine, tartar emetic, and gentian violet. Its heat inactivation temperature is between 45 degrees and 50 degrees C., at a time interval of 15 minutes. 8. Attempts to preserve the infectious agent in glycerine were unsuccessful. 9. The accumulated evidence suggests that the infectious agent of trachoma is a virus.
Chronic Bacterial Prostatitis Detected by FDG PET/CT in a Patient Presented With Fever of Unknown Origin
Authors: Kuan-Hsiu Lin, Yao-Shen Chen, Gin Hu, Daw-Guay Tsay, Nan-Jing Peng
Journal: Clinical Nuclear Medicine (2010)

A 45-year-old man had fever of unknown origin. FDG PET/CT was prescribed to seek the source of fever, which showed intense FDG uptake in bilateral posterolateral lobes of prostate. Laboratory data showed elevation of serum prostate-specific antigen (PSA) level to 15.6 ng/mL. Urine after prostate massage showed pyuria and culture of prostatic secretion yielded Pseudomonas aeruginosa. Transrectal ultrasound-guided biopsy showed inflammatory cells infiltration. Therefore, chronic bacterial prostatitis was impressed. After initiating antibiotic therapy with ciprofloxacin, fever subsided, and the result of urine analysis and serum PSA level returned to normal range later. In this case, FDG PET/CT correctly found the infective source in a patient presenting with fever of unknown origin.
Hungarian home birth advocate is jailed after "long campaign of harassment" against her
Authors: N. Stafford
Journal: BMJ (2010)

An internationally recognised obstetrician and midwife has been held in a maximum security Hungarian prison since early October after a pregnant woman unexpectedly went into labour at her home birthing centre in Budapest and gave birth to a baby boy who had serious breathing difficulties and had to be transferred to hospital.

Agnes Gereb’s imprisonment while the case is investigated has triggered widespread condemnation from around the world.

The doctor is already facing criminal charges in four separate cases brought against her and four colleagues during the past few years. The four counts, being considered at the same time by one court, relate to home births where the mother or child had complications. In two of the births the mothers had a …
Effect of multiple patient reminders in improving diabetic retinopathy screening. A randomized trial.
Authors: R J Halbert, K M Leung, J M Nichol, A P Legorreta
Journal: Diabetes Care (1999)

OBJECTIVE: To determine whether multiple mailed patient reminders can produce an increase in the rate of diabetic retinal examinations (DRE) over that seen with a single reminder. RESEARCH DESIGN AND METHODS: All diabetic members &amp;gt; or = 18 years who were enrolled in a large network-based health maintenance organization (HMO) in California from August 1996 to July 1997 were identified using claims and pharmacy databases. Members who had no record of DRE in the HMO's claims database were then randomized into two groups. Both groups received mailed educational materials and a reminder to obtain the examination. Their physician groups also received a letter explaining the program, current guidelines for DRE, and a list of their diabetes patients with their DRE status. The single intervention group received no additional reminders. The multiple intervention group received additional reminders at 3, 6, and 9 months after baseline if they continued with no record of service, as determined from the claims database. RESULTS: The study cohort comprised 19,523 diabetic members, which were randomized into single (n = 9,614) and multiple (n = 9,909) intervention groups. There was an increase in monthly DRE rates after the intervention in August 1996 for both intervention groups. After the second reminder was sent to the multiple intervention group, the percentage of diabetic members receiving DRE was higher than the single intervention group. Rates before and after the third intervention were not significantly different, nor were monthly differences found. There was a significant difference in overall annual DRE rates between the groups (P = 0.023). CONCLUSIONS: Multiple patient reminders are more effective than single reminders in improving DRE rates in a managed care setting. However, the improvement noted was clinically small and appeared only after the second reminder; no incremental improvement was seen with additional reminders. Resources used for multiple reminders aimed at diabetic retinopathy might better be spent on other approaches to reducing complications of diabetes.
Deontological foundations for medical ethics?
Authors: R Gillon
Journal: BMJ (1985)

Gillon outlines the principles of the deontological, or duty-based, group of moral theories in one of a series of British Medical Journal articles on the philosophical foundations of medical ethics. He differentiates between monistic theories, such as Immanuel Kant's, which rely on a single moral principle, and pluralistic theories, such as that of W.D. Ross, which rely on several principles that potentially could conflict. He summarizes the contributions of Kant and Ross to the development of deontological thought, then concludes his essay with brief paragraphs on other deontological approaches to the resolution of conflicting moral principles.
PGE<sub>1</sub>-induced NO reduces apoptosis by D-galactosamine through attenuation of NF-κB and NOS-2 expression in rat hepatocytes
Authors: Emilio Siendones, Dalia Fouad, María José M. Díaz–Guerra, Manuel de la Mata, Lisardo Boscá, Jordi Muntané
Journal: Hepatology (2004)

Prostaglandin E1 (PGE1) reduces cell death in experimental and clinical liver dysfunction. We have previously shown that PGE1 preadministration protects against NO–dependent cell death induced by d–galactosamine (D–GalN) through a rapid increase of nuclear factor κB (NF–κB) activity, inducible NO synthase (NOS–2) expression, and NO production. The present study investigates whether PGE1–induced NO was able to abolish NF–κB activation, NOS–2 expression, and apoptosis elicited by D–GalN. Rat hepatocytes were isolated following the classical method of collagenase perfusion of liver. PGE1 (1 μmol/L) was administered 2 hours before D–GalN (5 mmol/L) in primary culture rat hepatocytes. PGE1 reduced inhibitor κBα degradation, NF–κB activation, NOS–2 expression, and apoptosis induced by D–GalN. The administration of an inhibitor of NOS–2 abolished the inhibitory effect of PGE1 on NF–κB activation and NOS–2 expression in D–GalN-treated hepatocytes. Transfection studies using different plasmids corresponding to the NOS–2 promoter region showed that D–GalN and PGE1 regulate NOS–2 expression through NF–κB during the initial stage of hepatocyte treatment. PGE1 was able to reduce the promoter activity induced by D–GalN. In addition, a NO donor reduced NOS–2 promoter activity in transfected hepatocytes. In conclusion , administration of PGE1 to hepatocytes produces low levels of NO, which inhibits its own formation during D–GalN-induced cell death through the attenuation of NF–κB-dependent NOS–2 expression. Therefore, a dual role for NO in PGE1–treated D–GalN-induced toxicity in hepatocytes is characterized by a rapid NO release that attenuates the late and proapoptotic NOS–2 expression. Supplementary material for this article can be found on the Hepatology website ( http://interscience.wiley.com/jpages/0270–9139/suppmat/index.html ). (Hepatology 2004;40:1295-1303.)
Effect of increased free fatty acids on myocardial oxygen extraction and angina threshold during atrial pacing.
Authors: G R Dagenais, B Jalbert
Journal: Circulation (1977)

To evaluate whether elevated arterial free fatty acids (FFA) increase myocardial oxygen demand and ischemia, 15 fasting patients with coronary artery disease underwent a standardized atrial pacing test before (PTI) and during (PT2) heparin infusion. The patients were monitored for clinical and electrocardiographic (ECG) manifestations of ischemia. Myocardial extraction of lactate, inorganic phosphate, oxygen and FFA was measured before and during each PT. The control arterial FFA was 0.65 +/- 0.03 micromole/ml and rose to 1.83 +/- 0.16 micromole/ml during heparin influsion. Myocardial oxygen extraction at rest and during PT was not affected by the increase in arterial FFA. Seven patients asymptomatic during PT1 did not develop ischaemic manifestations during PT2. In eight patients with angina during both PTs, increased arterial FFA concentration did not modify the severity of anginal pain, the amount of ST-segment depression and the myocardial balance of lactate or inorganic phosphate. Elevation of arterial FFA by heparin neither increased myocardial oxygen extraction at rest or during pacing nor accentuated ischemic manifestations during PT.
Women's health team of the year
Authors: N. Hawkes
Journal: BMJ (2015)

Changing expectations is the theme that links the five shortlisted entries in the Women’s Health team category of the BMJ awards, says <b>Nigel Hawkes</b>. Rather than dramatic breakthroughs in care, the teams succeeded by using existing knowledge better through persuasion, training, and altering entrenched attitudes. Teamwork, openness, and a willingness to share perceptions good and bad were common factors
Transesophageal Ultrasound-Guided Fine-Needle Aspiration for the Mediastinal Restaging of Non-small Cell Lung Cancer
Authors: Martin B. von Bartheld, Michel I.M. Versteegh, Jerry Braun, Luuk N.A. Willems, Klaus F. Rabe, Jouke T. Annema
Journal: Journal of Thoracic Oncology (2011)