tbuckley/cabot-search huggingface dataset:
Hypercapnia via Reduced Rate and Tidal Volume Contributes to Lipopolysaccharide-induced Lung Injury
Authors: John D. Lang, Mario Figueroa, K. David Sanders, Mutay Aslan, Yuliang Liu, Phillip Chumley, Bruce A. Freeman
Journal: American Journal of Respiratory and Critical Care Medicine (2004)

Appreciating that CO2 modifies the chemical reactivity of nitric oxide (NO)-derived inflammatory oxidants, we investigated whether hypercapnia would modulate pulmonary inflammatory responses. Rabbits (n = 72) were ventilated with approximately 7-ml/kg tidal volume for 6 hours. Animals were randomized to one of the following conditions: eucapnia (Pa(CO2) at approximately 35-40 mm Hg), eucapnia + lipopolysaccharide (LPS), eucapnia + LPS + inhaled NO (iNO delivered at approximately 20 ppm), hypercapnia (Pa(CO2) at approximately 60 mm Hg), hypercapnia + LPS, and hypercapnia + LPS + iNO. The hypercapnia + LPS groups compared with groups exposed to eucapnia + LPS displayed significantly increased bronchoalveolar lavage fluid protein concentrations (p < 0.05), lung wet-to-dry ratios (p < 0.05), bronchoalveolar lavage fluid cell counts (p < 0.05), and lung histologic alterations consistent with greater injury. Furthermore, expression of inducible nitric oxide synthase (p < 0.05), tissue myeloperoxidase content (p < 0.05), and formation of lung protein 3-nitrotyrosine derivatives (p < 0.05) was greatest under conditions of hypercapnia + LPS. Groups exposed to hypercapnic conditions without LPS did not manifest these changes. The inhalation of iNO attenuated selected indices of lung injury. We conclude that hypercapnia induced by means of reduced rate and tidal volume amplifies pulmonary inflammatory responses.
Cardiomyocyte-Specific Deletion of Gsk3α Mitigates Post–Myocardial Infarction Remodeling, Contractile Dysfunction, and Heart Failure
Authors: Firdos Ahmad, Hind Lal, Jibin Zhou, Ronald J. Vagnozzi, Justine E. Yu, Xiying Shang, James R. Woodgett, Erhe Gao, Thomas Force
Journal: Journal of the American College of Cardiology (2014)
Urinary metabolites of 14C-labeled thyroxine in man
Authors: Constance S. Pittman, Melvin W. Buck, Joseph B. Chambers
Journal: Journal of Clinical Investigation (1972)

Studies were carried out to determine the chemical structures of thyroxine metabolites after total deiodination. Normal subjects were given thyroxine labeled with 14C on the nonphenolic ring and the alanine side chain, 8-11 μg/day for 10 days. By paper chromatography of fresh urine, six or more 14C-labeled compounds were separated. The 14C-labeled metabolites were concentrated by passing the urine through a nonionic polymeric adsorbent. Two major thyroxine metabolites were identified. The identification was made by three different methods: (a) chromatography, (b) synthesis of derivatives, and (c) recrystallization to constant specific activity. One 14C-labeled metabolite was identified as thyroacetic acid or 4-phenoxy-(4′-hydroxy) phenyl-acetic acid. Another one was identified as thyronine. Of the total urinary 14C radioactivity, 43.7% was recovered as thyroacetic acid and 19.8% was recovered as thyronine. Approximately one-fifth of each of these metabolites was present in the urine in bound form which released the free metabolites during acid hydrolysis. The average daily excretion of thyroacetic acid was 13.7% of the renal disposal rate of thyroxine, or approximately 7.5 μg/day. The average daily excretion of thyronine was 6.5% of the renal disposal rate of thyroxine or approximately 3.9 μg/day while the urinary iodide made up 64.7% of the renal disposal rate of thyroxine. Our findings provide the needed proof that the major metabolic pathways of thyroxine remove the iodine atoms by substituting hydrogen for iodine and leave the diphenyl ether nucleus intact.
Topical corticosteroid therapy for acute radiation dermatitis: a prospective, randomized, double-blind study
Authors: M. Schmuth, M.A. Wimmer, S. Hofer, A. Sztankay, G. Weinlich, D.M. Linder, P.M. Elias, P.O. Fritsch, E. Fritsch
Journal: British Journal of Dermatology (2002)

Journal Article Topical corticosteroid therapy for acute radiation dermatitis: a prospective, randomized, double‐blind study Get access M. Schmuth, M. Schmuth Departments of Dermatology and Matthias Schmuth, Department of Dermatology, Anichstr. 35, A‐6020, Innsbruck, Austria. E‐mail: matthias.schmuth@uibk.ac.at Search for other works by this author on: Oxford Academic Google Scholar M.A. Wimmer, M.A. Wimmer Radiotherapy and Radiation Oncology, University of Innsbruck, Austria Search for other works by this author on: Oxford Academic Google Scholar S. Hofer, S. Hofer Departments of Dermatology and Search for other works by this author on: Oxford Academic Google Scholar A. Sztankay, A. Sztankay Radiotherapy and Radiation Oncology, University of Innsbruck, Austria Search for other works by this author on: Oxford Academic Google Scholar G. Weinlich, G. Weinlich Departments of Dermatology and Search for other works by this author on: Oxford Academic Google Scholar D.M. Linder, D.M. Linder Departments of Dermatology and Search for other works by this author on: Oxford Academic Google Scholar P.M. Elias, P.M. Elias Department of Dermatology, University of California, San Francisco, CA, U.S.A Search for other works by this author on: Oxford Academic Google Scholar P.O. Fritsch, P.O. Fritsch Departments of Dermatology and Search for other works by this author on: Oxford Academic Google Scholar E. Fritsch E. Fritsch Radiotherapy and Radiation Oncology, University of Innsbruck, Austria Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 146, Issue 6, 1 June 2002, Pages 983–991, https://doi.org/10.1046/j.1365-2133.2002.04751.x Published: 01 June 2002 Article history Accepted: 07 January 2002 Published: 01 June 2002
Effect of Changes in Limb Posture on Peripheral Blood Flow
Authors: PETER BEACONSFIELD, JEAN GINSBURG
Journal: Circulation Research (1955)

Venous occlusion plethysmography was used to measure the effect of changes in limb position on the peripheral blood flow. The validity of the method with the limb dependent was investigated, and found to be reliable in the conditions of the experiment. The blood flow in the limb was found to be decreased when it was raised or lowered 45 degrees. At 15 degrees of elevation, the flow was increased. Similar changes were found in recently sympathectomized limbs. The reactions may therefore be regarded as local vascular responses to postural change.
Glucose regulation of hydroperoxide metabolism in rat intestinal cells. Stimulation of reduced nicotinamide adenine dinucleotide phosphate supply.
Authors: T Y Aw, C A Rhoads
Journal: Journal of Clinical Investigation (1994)

The regulation of intestinal metabolism of t-butylhydroperoxide by glucose was examined in isolated enterocytes from proximal rat intestine. The basal rate of hydroperoxide elimination in control cells was 0.57 +/- 0.05 nmol/min per 10(6) cells, and was increased threefold by 10 mM exogenous glucose (1.74 +/- 0.14 nmol/min per 10(6) cells). Concurrently, cellular NADPH levels increased threefold (1.62 +/- 0.40 nmol/10(6) cells vs 0.57 +/- 0.14 nmol/10(6) cells in controls). The glucose effect was blocked by 6-aminonicotinamide and by 1,3-bis-(2-chloroethyl) 1-nitrosourea, consistent with glucose stimulation of NADPH production by the pentose phosphate shunt, and of NADPH utilization for glutathione disulfide reduction. The NADPH supply rate was quantified by controlled infusions of diamide, a thiol oxidant. At diamide infusion of 0.05 nmol/min per 10(6) cells, GSH and protein thiols in control cells were decreased significantly, consistent with a limited capacity for glutathione disulfide reduction. With glucose, cell GSH and protein thiols were preserved at a 10-fold higher diamide infusion which was reversed by 6-aminonicotinamide, supporting the view that glucose promotes glutathione disulfide reduction by increased NADPH supply. Collectively, the results demonstrate that intestinal metabolism of hydroperoxides subscribes to regulation by glucose availability. This responsiveness to glucose suggests that nutrient availability would be an important contributing factor in the detoxication of toxic hydroperoxides by the small intestine.
Economic and clinical analysis of elective percutaneous coronary intervention without on-site cardiac surgery
Authors: Kirsten Hall Long, Henry H. Ting, Erin K. Mc Murtry, Aaron S. Terry, Thomas H. Tiggelaar, Ryan J. Lennon, Kirk N. Garratt, Mandeep Singh, Charanjit S. Rihal, Douglas L. Wood, David R. Holmes
Journal: Journal of the American College of Cardiology (2003)
The Association of NAD(P)H Oxidase p22phox With Diabetic Nephropathy Is Still Uncertain
Authors: Kent Doi, Eisei Noiri, Katsushi Tokunaga
Journal: Diabetes Care (2004)

We believe that there are limitations in the study by Hodgkinson, Millward, and Demaine (1) about the association of the NAD(P)H oxidase p22phox polymorphisms with susceptibility to diabetic nephropathy. The case-control association studies on the polymorphisms in p22phox have been performed by a number of researchers, and their results are …
Forward modeling allows feedback control for fast reaching movements
Authors: Michel Desmurget, Scott Grafton
Journal: Trends in Cognitive Sciences (2000)

Delays in sensorimotor loops have led to the proposal that reaching movements are primarily under pre-programmed control and that sensory feedback loops exert an influence only at the very end of a trajectory. The present review challenges this view. Although behavioral data suggest that a motor plan is assembled prior to the onset of movement, more recent studies have indicated that this initial plan does not unfold unaltered, but is updated continuously by internal feedback loops. These loops rely on a forward model that integrates the sensory inflow and motor outflow to evaluate the consequence of the motor commands sent to a limb, such as the arm. In such a model, the probable position and velocity of an effector can be estimated with negligible delays and even predicted in advance, thus making feedback strategies possible for fast reaching movements. The parietal lobe and cerebellum appear to play a crucial role in this process. The ability of the motor system to estimate the future state of the limb might be an evolutionary substrate for mental operations that require an estimate of sequelae in the immediate future.
Septic arteritis complicating salmonellosis.
Authors: P H Winocour, G R Williams, J F Boyd, D H Kennedy
Journal: BMJ (1983)

Intestinal infection with salmonella is associated with a low but definite mortality.We report the clinical findings of two recent deaths where necropsy showed septic arteritis, a rare but recog- nised complication, and discuss the need for more immediate use of antibiotics in patients at risk.Metastatic infection should be considered in older patients with salmonella infection Case reports CASE 1An 84 year old man was transferred from a surgical unit with a three week history of watery diarrhoea.Salmonella typhimurium had been isolated from stool culture.Intravenous fluids were required initially in the surgical unit.The medical history was of inferior myocardial infarction in 1973 and vagotomy and gastrojejunostomy in 1979.On examination he had no abnorm- ality apart from an abdominal scar.Mild hypokalaemia of 2-8 mmol(mEq)/l, readily corrected with oral supplements, was the only abnormal laboratory finding.Stool frequency thereafter was up to three times a day, and S typhimurium was repeatedly isolated.He improved generally, although he remained weak.After seven days fever developed, associated with mild dysuria, frequency, and low backache (fig 1).Only the first of three blood cultures, taken during spikes of fever, grew S typhimiurium.Of three urine cultures, Escherichia coli was grown from only one specimen with scanty pyuria in all three.The fever settled without antibiotic treatment.He remained well apart from persistent backache.Right basal lung crepitations developed but a chest x ray film showed no abnormality.Sputum culture later yielded four potential pathogens.The backache of presumed musculoskeletal origin slowly intensified, radiating to both buttocks.It was readily relieved by analgesics.The left femoral pulse was reduced in volume.Seventeen days after admission lower abdominal pain, haematuria, and hypotension developed.The left femoral pulse was very weak and a tender pulsating periumbilical mass was palpable with an associated bruit.An electrocardiogram showed acute inferolateral ischaemic changes.Despite active resuscita- tion he died later that day.At necropsy severe generalised calcifying atheroma with ulceration was seen throughout the major vessels.There was a fusiform aneurysm caudal to the renal arteries, but no mural thrombus.The right common iliac artery showed localised
The late prognosis of perforated duodenal ulcer
Authors: A. C. B. Dean, C. G. Clark, A. H. Sinclair-Gieben
Journal: Gut (1962)

One hundred and seventy cases of perforated duodenal ulcer have been followed up after eight to 10 years. Simple suture of the perforation is recommended. The decision to perform elective surgery is best made during the first two years after perforation rather than at the time of the emergency procedure.
P68ERbeta prevents up-regulation of miRNAs under pressure overload in LV of female mice
Authors: H Sanchez Ruderisch, AM Queiros, D Fliegner, C Eschen, G Kararigas, V Regitz-Zagrosek
Journal: Cardiovascular Research (2014)

Sex differences have been observed in patient with aortic stenosis, women develop a more concentric form of myocardial hypertrophy than men and men have a stronger activation of profibrotic genes. Transverse aortic constriction induces more ventricular dilatation and fibrosis in male than in female mice which is partially mediated by oestrogen receptor beta (ERβ). Cardiac microRNAs contribute to the regulation of gene expression in hypertrophy but their control by sex or ERβ is yet unknown. We therefore analysed whether cardiac microRNA are regulated by sex or ERβ, whether this occurs under pressure overload and affects hypertrophy associated pathways.
Cholelithiasis in Singapore: Part II A clinical study
Authors: H. K. Chiam, P. N. Unni, W. S. Hwang
Journal: Gut (1970)

In the present study of 241 patients submitted for gallbladder and biliary tract surgery, it is found that choledocholithiasis in cases in Singapore presents with a wide spectrum of clinical manifestations. It is essential that the less common clinical presentations should be recognized.
Noninvasive assessment of ventricular relaxation and contractility indices by analysis of intraventricular ejection pressure-gradient curves derived from doppler echocardiography
Authors: Raquel Yotti, Javier Bermejo, Carlos Antoranz, Jacobo Silva, Carmen Allue, Jose Luis Rojo, Mar Moreno, Miguel Angel Garcia Fernandez
Journal: Journal of the American College of Cardiology (2003)
IMMUNOGLOBULINS IN SERUM AND NASAL SECRETION. A COMPARISON BETWEEN PATIENTS WITH ASPIRIN HYPERSENSITIVITY AND ALLERGIC RHINITIS
Authors: C. M. BHANDARI, L. ROSENHALL, H. DEUSCHL
Journal: Allergy (1977)

Immunoglobulins A, E and G were studied in serum and nasal secretion from patients with allergic rhinitis, chronic rhinitis and aspirin hypersensitivity, and normal controls. The allergic patients differed from the other groups in having higher IgE values, both in serum and in nasal secretion. The patients with aspirin hypersensitivity did not differ from the control group regarding the IgE values. No difference between the groups was found with respect to IgA and IgG. The results indicate that reaginic antibodies are not involved in causing aspirin hypersensitivity.
Abstract 2852: Combination therapy: Galectin-3C and bortezomib potent anticancer activity and inhibition of angiogenesis, chemotaxis, and NF-kB activation in human multiple myeloma
Authors: Yuefei Yu, Leonardo Mirandola, Marjorie R. Jenkins, Everardo Cobos, Maurizio Chiriva-Internati, Kitty Chui, Constance M. John
Journal: Cancer Research (2012)

Abstract Introduction Galectin-3 is a human lectin involved in cellular processes including differentiation, apoptosis, angiogenesis, neoplastic transformation, and metastasis. We evaluated galectin-3C, an N-terminally truncated form of galectin-3 that is thought to act as a dominant negative inhibitor, as a potential treatment for multiple myeloma (MM). Methods We analyzed 9 human MM cell lines tested in vitro for cell proliferation/viability; chemotaxis. The human MM cell lines used in this study were RPMI-8226, U266 (American Type Culture Collection, VA, USA), ARP-1, ARK-B, (gifts from J. Epstein, University of Arkansas for Medical Sciences, Little Rock, AR, USA). The 8226/Dox and 8226/LR-5 cell lines were kindly provided by Dr. William S. Dalton of the H. Lee Moffitt Cancer Center and Research Institute in Tampa, Florida. All MM cells were cultured in RPMI-1640 medium supplemented with 10% fetal bovine serum (FBS) in 5% CO2 at 37 °C. The 8226/Dox cells were cultured with 40 nM doxorubicin (Sigma-Aldrich, St. Louis, MO, USA). The 8226/LR-5 cells were cultured in media containing 5 µM mephalan (Sigma-Aldrich). 8226/Dox and 8226/LR-5 cells were maintained in drug-free medium for 1 week prior to drug sensitivity assays. Human umbilical cord vascular endothelial cells (HUVEC, American Type Culture Collection, VA, USA) were maintained in EGM-2 medium (Lonza, Houston, TX, USA) and were used within 10 passages. Furthermore we used U266 MM model in the NOD/SCID mice to evaluate the efficacy of galectin-3C in single or in combination with BOR. Results Galectin-3C exhibited modest anti-proliferative effects on MM cells in vitro. Delivery of galectin-3C intravenously via an osmotic pump in a subcutaneous U266 cell NOD/SCID mouse model of MM significantly inhibited tumor growth. Bortezomib, a proteasome inhibitor approved by the F.D.A. for MM treatment, also inhibited the growth of the U266 tumors. Treatment with both agents was more effective than either alone, such that the average tumor volume of the combination group was just 14.0% of controls at day 35. We show that mechanisms by which galectin-3C facilitates the anticancer activity of BOR include inhibition of angiogenesis, chemotaxis, and NF-kB activation. Conclusion In conclusion, our study shows that in a mouse model of human MM, treatment with galectin-3C alone is efficacious, and that it enhances the anti-tumor activity of bortezomib. These findings provide the proof-of-principle to test galectin-3C clinically for human MM. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2852. doi:1538-7445.AM2012-2852
Report from the NOAA workshops to standardize protocols for monitoring toxic Pfiesteria species and associated environmental conditions.
Authors: D Luttenberg, D Turgeon, J Higgins
Journal: Environmental Health Perspectives (2001)

Long-term monitoring of water quality, fish health, and plankton communities in susceptible bodies of water is crucial to identify the environmental factors that contribute to outbreaks of toxic Pfiesteria complex (TPC) species. In the aftermath of the 1997 toxic Pfiesteria outbreaks in North Carolina and Maryland, federal and several state agencies agreed that there was a need to standardize monitoring protocols. The National Oceanic & Atmospheric Administration convened two workshops that brought together state, federal, and academic resource managers and scientific experts to a) seek consensus on responding to and monitoring potential toxic Pfiesteria outbreaks; b) recommend standard parameters and protocols to characterize water quality, fish health, and plankton at historical event sites and potentially susceptible sites; and c) discuss options for integrating monitoring data sets from different states into regional and national assessments. Workshop recommendations included the development of a three-tiered TPC monitoring strategy: Tier 1, rapid event response; Tier 2, comprehensive assessment; and Tier 3, routine monitoring. These tiers correspond to varying levels of water quality, fish health, and plankton monitoring frequency and intensity. Under the strategy, sites are prioritized, depending upon their history and susceptibility to TPC events, and assigned an appropriate level of monitoring activity. Participants also agreed upon a suite of water quality parameters that should be monitored. These recommendations provide guidance to state and federal agencies conducting rapid-response and assessment activities at sites of suspected toxic Pfiesteria outbreaks, as well as to states that are developing such monitoring programs for the first time.
Early Versus Deferred Cystectomy for Initial High-Risk pT1G3 Urothelial Carcinoma of the Bladder: Do Risk Factors Define Feasibility of Bladder-Sparing Approach?
Authors: Stefan Denzinger, Hans-Martin Fritsche, Wolfgang Otto, Andreas Blana, Wolf-Ferdinand Wieland, Maximilian Burger
Journal: European Urology (2007)
Neurological Complications of Infective Endocarditis
Authors: J. Garfield
Journal: BMJ (1970)

Nasal Cancer in the Shoe Industry SIR,-In our article on "Nasal Cancer in the Northamptonshire Boot and Shoe Industry" (14 February, p. 385) we were unable to give estimates of incidence within the industry because we lacked comprehensive information on the numbers of men employed in the different departments.We have since received from the British Foot- wear Manufacturers' Federation national figures relating to 1949-61 inclusive giving the numbers of operatives in each sex employed in the various departments.The figures include the numbers of men and women employed in clicking, closing, pressing, lasting, finishing, and shoe room departments.In making the calculations in the Table the figures for 1949-61 have been averaged and the proportions applied to the Northamptonshire industry.If the cases of Adenocarcinoma Other Carcinomas All Carcinomas
[224] THE IMPACT OF SUSTAINED VIROLOGICAL RESPONSE ON CLINICAL OUTCOMES IN COMPENSATED HCV CIRRHOSIS: A PROSPECTIVE COHORT STUDY
Authors: V. Di Marco, V. Calvaruso, S. De Lisi, P.L. Almasio, D. Ferraro, S. Peralta, P. Parisi, G. Alaimo, N. Alessi, R. Di Stefano, A. Craxi
Journal: Journal of Hepatology (2007)
New Ministers and New Ideas — Changes at the General Medical Council — Defying a Postal Strike
Authors: John Lister
Journal: New England Journal of Medicine (1979)

AS anticipated, when Mrs. Margaret Thatcher-formed her new government, she appointed Mr. Patrick Jenkin to be Secretary of State in the Department of Health and Social Security (DHSS), with Dr. Gerard Vaughan as Minister of Health. During the last few years, both men have acted as opposition spokesmen on matters relating to health and social security, and they therefore assume office with wide experience concerning the problems of the National Health Service (NHS); Dr. Vaughan has the additional advantage of having been a practicing psychiatrist. They are both committed to upholding the principles of the NHS, but they made it . . .