tbuckley/cabot-search huggingface dataset:
Survival prognostic factors and markers of morbidity in Spanish patients with systemic sclerosis
Authors: C.-P. Simeon, L. Armadans, V. Fonollosa, M. Vilardell, J. Candell, C. Tolosa, F. Mearin, M. J. Rodrigo, R. Solans, J. Lima, G. Sampol
Journal: Annals of the Rheumatic Diseases (1997)

<h3>OBJECTIVE</h3> To identify survival prognostic factors and markers of morbidity among patients with systemic sclerosis (SSc). <h3>PATIENTS AND METHODS</h3> The study included 72 patients diagnosed with SSc. According to the extent of skin involvement, three groups of patients were established: group 1, without sclerosis and with sclerosis of fingers and neck; group 2, with sclerosis of face and distal to elbows and knees; group 3, with generalised sclerosis including the trunk. All patients were included in a study protocol to determine visceral involvement. Cumulative survival after first symptom has been estimated according to the Kaplan-Meier method. The association between a hypothetical prognostic factor and cumulative survival after first symptom was assessed by log rank test. The association between a hypothetical risk factor and the prevalence of severe morbity was assessed by the odds ratio. Multiple logistic regression models were used to identify the main predictors of severe morbidity. <h3>RESULTS</h3> Survival was estimated to be 85% 10 years after first SSc symptom. Survival was higher among SSc patients with skin involvement distal to elbows and knees than among the rest of patients; a forced vital capacity (FVC) on spirometry lower than 70% of expected value was associated with a shorter survival, even after adjustment for diffuse SSc. Skin involvement proximal to elbows or knees was associated with a higher prevalence of severe morbidity (OR = 46.57; p&lt;0.001). According to a multiple logistic regression, severe morbidity was higher among patients with skin involvement proximal to knees or elbows (OR = 40.92; p&lt;0.001) or among patients with pulmonary hypertension detected by Doppler echocardiography (OR = 23.66 p&lt;0.001). <h3>CONCLUSIONS</h3> In patients with SSc the extent of skin sclerosis was found to be a determining factor on the prognosis. According to skin sclerosis extent two main subsets of SSc patients with different survival incidence and degree of morbidity could be clearly established: limited SSc, formed by patients with no skin sclerosis or with sclerosis distal to elbows and knees and diffuse SSc, formed by patients with skin sclerosis distal and proximal to elbows and knees. Moreover, lung involvement (FVC&lt;70% on survival study and pulmonary hypertension on morbidity study) was an important and independent prognostic factor.
Erythema annulare centrifugum induced by generalized Phthirus pubis infestation
Authors: D. Bessis, H. Chraibi, B. Guillot, J-J. Guilhou
Journal: British Journal of Dermatology (2003)

A 59‐year‐old man was admitted for the evaluation of diffuse pruritic cutaneous lesions lasting for at least 2 months. Cutaneous examination revealed multiple erythematous, annular lesions with raised, scaly borders, roughly symmetrical in pattern, involving the trunk, the buttocks (Fig. 1) and the upper and lower limbs. All the lesions were predominantly located on the hairy areas. Several Phthirus pubis adults associated with a multitude of lice nits were easily visualized and confirmed by microscopic examination. Large and oval asymptomatic blue maculas were also noted on the lower abdomen and the buttocks. A biopsy performed in the border of an annular lesion revealed acanthosis, papillomatosis and subepidermal oedema as well as a moderate perivascular infiltrate composed of lymphocytes in the upper dermis. Treatment involved complete shaving of the hair and two successive topical applications of benzyl benzoate solution 12 h apart. The outcome was marked by a dramatic improvement of the pruritus within 48 h followed by a rapid and complete clearing of the erythematous lesions. Our observation is unusual, as we describe for the first time the induction of erythema annulare centrifugum by generalized P. pubis infestation.
Tackling cardiovascular disease in Africa
Authors: S Kadiri
Journal: BMJ (2005)

Will need much more than just imported measures from more developed countries 

I n the past four decades Africa has witnessed increasing urbanisation and changing lifestyles, factors which have, in turn, raised the incidence of non-communicable chronic diseases, especially cardiovascular disease. At the same time social disintegration and inequality, compounded by the dwindling economy in many countries in sub-Saharan Africa, have seriously hindered the response to these non-communicable diseases. Moreover, communicable diseases are still rife, using up health resources, and actions to deal with communicable diseases have often been based on data from smaller studies, usually hospital based. The situation is cause for concern.

Cardiovascular disease has reached near epidemic proportions in Africa. According to the World Health Report 2002 , cardiovascular disease accounted for 9.2% of total deaths in the African region in 2001, and hypertension, stroke, cardiomyopathies and …
A phase 1/2 study of carfilzomib in combination with lenalidomide and low-dose dexamethasone as a frontline treatment for multiple myeloma
Authors: Andrzej J. Jakubowiak, Dominik Dytfeld, Kent A. Griffith, Daniel Lebovic, David H. Vesole, Sundar Jagannath, Ammar Al-Zoubi, Tara Anderson, Brian Nordgren, Kristen Detweiler-Short, Keith Stockerl-Goldstein, Asra Ahmed, Terri Jobkar, Diane E. Durecki, Kathryn McDonnell, Melissa Mietzel, Daniel Couriel, Mark Kaminski, Ravi Vij
Journal: Blood (2012)
Second Malignant Neoplasms in Patients With Cowden Syndrome With Underlying Germline <i>PTEN</i> Mutations
Authors: Joanne Ngeow, Kim Stanuch, Jessica L. Mester, Jill S. Barnholtz-Sloan, Charis Eng
Journal: Journal of Clinical Oncology (2014)

Patients with Cowden syndrome (CS) with underlying germline PTEN mutations are at increased risk of breast, thyroid, endometrial, and renal cancers. To our knowledge, risk of subsequent cancers in these patients has not been previously explored or quantified.We conducted a 7-year multicenter prospective study (2005 to 2012) of patients with CS or CS-like disease, all of whom underwent comprehensive PTEN mutational analysis. Second malignant neoplasms (SMNs) were ascertained by medical records and confirmed by pathology reports. Standardized incidence ratios (SIRs) for all SMNs combined and for breast, thyroid, endometrial, and renal cancers were calculated.Of the 2,912 adult patients included in our analysis, 2,024 had an invasive cancer history. Germline pathogenic PTEN mutations (PTEN mutation positive) were identified in 114 patients (5.6%). Of these 114 patients, 46 (40%) had an SMN. Median age of SMN diagnosis was 50 years (range, 21 to 71 years). Median interval between primary cancer and SMN was 5 years (range, <1 to 35 years). Of the 51 PTEN mutation-positive patients who presented with primary breast cancer, 11 (22%) had a subsequent new primary breast cancer and 10-year second breast cancer cumulative risk of 29% (95% CI, 15.3 to 43.7). Risk of SMNs compared with that of the general population was significantly elevated for all cancers (SIR, 7.74; 95% CI, 5.84 to 10.07), specifically for breast (SIR, 8.92; 95% CI, 5.85 to 13.07), thyroid (SIR, 5.83; 95% CI, 3.01 to 10.18), and endometrial SMNs (SIR, 14.08.07; 95% CI, 7.10 to 27.21).Patients with CS with germline PTEN mutations are at higher risk for SMNs compared with the general population. Prophylactic mastectomy should be considered on an individual basis given the significant risk of subsequent breast cancer.
Disialoganglioside GD3 is selectively expressed by developing and mature human mast cells
Authors: Shunlin Ren, Naotomo Kambe, Zhongmin Du, Yongli Li, Han-Zhang Xia, Michiyo Kambe, Erhard Bieberich, Andrea Pozez, Margaret Grimes, Robert K. Yu, Anne-Marie Irani, Lawrence B. Schwartz
Journal: Journal of Allergy and Clinical Immunology (2001)
NBT Test in Myocardial Infarction
Authors: F.R. DOUWES
Journal: Annals of Internal Medicine (1974)

Comments and Corrections1 February 1974NBT Test in Myocardial InfarctionF.R. DOUWES, M.D., L. REICHEL, M.D.F.R. DOUWES, M.D.Search for more papers by this author, L. REICHEL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-80-2-277_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptLauter and associates reported (Ann Intern Med79:59-62, 1973) a significant stimulation of nitroblue tetrazolium dye (NBT) reduction in patients with acute myocardial infarction, compared with patients suffering from infectious disease. They speculate that this granulocytic stimulation could be caused by fibrin, fibrinogen, and the breakdown products of these proteins. We have not been able to confirm their observation. In our earlier studies we reported that myocardial infarction, even if it is associated with leukocytosis or fever, does not result in a higher rate of NBT reduction. Since the publication of Lauter's findings, we have studied 21 cases of acute...References1. PARKFIKRIGSMITHWICK BSE: Infection and nitroblue tetrazolium reduction by neutrophils. A diagnostic aid. Lancet 2:532-534, 1968 CrossrefMedlineGoogle Scholar2. FEIGIN R: NBT test in the diagnosis of febrile patients. N Engl JMed 285:347-348, 1971 CrossrefMedlineGoogle Scholar3. MATULAPATTERSON CP: Spontaneous in vitro reduction of nitroblue tetrazolium by neutrophils of adult patients with bacterial infection. N Engl J Med 285:311-317, 1971 CrossrefMedlineGoogle Scholar4. DOUWES F: Clinical value of NBT test. N Engl J Med 287:822, 1972 CrossrefMedlineGoogle Scholar1. SOONATTRAKULANDERSEN WB: Diagnostic accuracy of the nitroblue tetrazolium test. Arch Intern Med 132:529-532, 1973 CrossrefMedlineGoogle Scholar2. BARNHART M: Importance of neutrophilic leukocytes in the resolution of fibrin. Fed Proc 24:846-853, 1965 MedlineGoogle Scholar3. BAELEMUSSCHEVERMEIRE GMP: Serum fibrin/fibrinogen degradation products in acute myocardial infarction. Lancet 1:689-690,1972 CrossrefMedlineGoogle Scholar4. FREEMANKING RB: Infective complications of indwelling intravenous catheters and the monitoring of infections by the nitroblue-tetrazolium test. Lancet 1:992-993, 1972 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine University of Göettingen Göettingen, West Germany PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1974Volume 80, Issue 2Page: 277-278KeywordsAcute myocardial infarctionFeversFibrinFibrinogenInfectious diseasesLeukocytosisMyocardial infarctionProteins Issue Published: 1 February 1974 PDF downloadLoading ...
Risk of hospitalisation for infections following TNF-blockade. Preliminary results of an ongoing Swedish monitoring-programme of biologics in RA
Authors: J Askling, C M Fored, L Brandt, E Baecklund, L Bertilsson, L Coster, P Geborek, L T Jacobsson, S Lindblad, J Lysholm, Solbritt Rantapää-Dahlqvist, T Saxne, N Feltelius, L Klareskog
Journal: Annals of the Rheumatic Diseases (2005)

Risk of hospitalisation for infections following TNF-blockade. Preliminary results of an ongoing Swedish monitoring-programme of biologics in RA
Instability of Hematin Used in the Treatment of Acute Hepatic Porphyria
Authors: C. Allen Goetsch, D. Montgomery Bissell
Journal: New England Journal of Medicine (1986)

The acute hepatic porphyrias are diseases in which the production of heme is deficient because of inherited abnormalities in specific enzymes of the heme synthetic pathway.1 The goal of therapy for these diseases is replenishment of cellular heme. This has been attempted clinically with intravenous administration of heme.2 3 4 Because of its poor solubility at neutral pH, heme is prepared as hematin in a bicarbonate solution at a pH of 8. Initial reports indicated that hematin was remarkably effective in severe acute porphyric attacks.2 , 3 However, the results were not uniform, and a more recent study suggested that hematin was frequently ineffective. . . .
Work disability and diabetes.
Authors: J A Mayfield, P Deb, L Whitecotton
Journal: Diabetes Care (1999)

OBJECTIVE: To determine the rates and demographic determinants of work disability, hours worked per week, work-loss days, and wages in individuals with diabetes. RESEARCH DESIGN AND METHODS: A probit regression analysis was performed on a cross-sectional population-based survey of U.S. noninstitutionalized civilian population (National Medical Expenditures Survey--2, 1987). The sample was restricted to individuals aged &amp;gt; or = 25 years. A total of 1,502 individuals reported having diabetes, and 20,405 did not. Information on workforce participation and income were collected quarterly. Work disability was defined as a self-report of having been unable to work because of illness or disability for &amp;gt; or = 2 quarters in 1987. RESULTS: Work disability was reported by 25.6% of individuals with diabetes, compared with 7.8% of those without diabetes. Work disability rates were higher for older people, females, and African-Americans, and lower for Hispanics and for individuals with greater non-wage income. Individuals with diabetes engaged in the workforce had more work-loss days than did nondiabetic individuals, but had similar hourly wages. Predicted mean earnings were significantly lower for individuals with diabetes at all ages, resulting in $4.7 million loss in earnings in 1987 due to work disability. CONCLUSIONS: Work disability is significantly higher for individuals with diabetes than for those without diabetes at all ages, and results in a significant decrease in earnings. A disproportionate burden of work disability is borne by older individuals and women with diabetes. Better information on the determinants of work disability in individuals with diabetes is needed.
A Non-C17-Alkylated Steroid and Long-term Cholestasis
Authors: VICENTE GARRIGUES GIL
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 January 1986A Non-C17-Alkylated Steroid and Long-term CholestasisVICENTE GARRIGUES GIL, M.D., JOAQUIN BERENGUER LAPUERTA, M.D., JULIO PONCE GARCIA, M.D., MIGUEL RAYON MARTIN, M.D.VICENTE GARRIGUES GIL, M.D.Search for more papers by this author, JOAQUIN BERENGUER LAPUERTA, M.D.Search for more papers by this author, JULIO PONCE GARCIA, M.D.Search for more papers by this author, MIGUEL RAYON MARTIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-104-1-135_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We report a case of intrahepatic cholestasis that occurred in a pregnant woman after she received a nonalkylated anabolic steroid.A 27-year-old woman (para 3, gravida 14 weeks) was admitted to our unit because of jaundice. Her family and personal histories were uneventful. Five-and-a-half months earlier, she had developed fatigue, nausea, and upper abdominal pain. Treatment with metoclopramide hydrochloride was given for a few days, and 50 mg of cyclohexylpropionate of 19-norandrostenolone was administered intramuscularly every 15 days. Four months later she complained of jaundice, mild pruritus, light stools, and dark urine without fever or chills. She...References1. ZIMMERMAN H. Hormonal derivatives and other drugs used to treat endocrine disease. In: ZIMMERMAN HJ, ed. Hepatotoxicity: The Adverse Effects of Drugs and Other Chemicals on the Liver. New York: Appleton-Century-Crofts, 1978:436-67. Google Scholar2. CARRASCOPALLARDOPRIETOMOLLCRUZBERENGUER DLMJJJ. Hepatic adenomata and androgen treatment [Letter]. Ann Intern Med. 1984;100:316. LinkGoogle Scholar3. TURANILEVIZEVINKESSLER HJDE. Hepatic lesions in patients on anabolic androgenic therapy. Isr J Med Sci. 1983;19:332-7. MedlineGoogle Scholar4. BAGHERIBOYER SJ. Peliosis hepatitis associated with androgenic-anabolic steroid therapy: a severe form of hepatic injury. Ann Intern Med. 1974;81:610-8. LinkGoogle Scholar5. FALKTHOMASPOPPERISHAK HLHK. Hepatic angiosarcoma associated with androgenic-anabolic steroids. Lancet. 1979;2:1120-3. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Hospital "La Fe" 46009 Valencia Spain PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByUse of Mesterolone, a non-alkylated anabolic steroid, in myelofibrosisSafety aspects of androgen therapy9 Drug-induced cholestasis 1 January 1986Volume 104, Issue 1Page: 135-136KeywordsAbdominal painFatigueFeversNauseaPregnancyPruritusUrine Issue Published: 1 January 1986 PDF DownloadLoading ...
A Subclavian Bruit in the Thoracic Outlet Syndrome
Authors: Peter J. Goadsby
Journal: Annals of Internal Medicine (1989)

Letters and Corrections15 February 1989A Subclavian Bruit in the Thoracic Outlet SyndromePeter J. Goadsby, MB, BS, PhDPeter J. Goadsby, MB, BS, PhDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-110-4-323_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The thoracic outlet syndrome is a relatively common problem, although full clinical characterization of the signs may be difficult. Cervical rib is not only a cause of the syndrome but also a well-described anatomic variant occurring in 0.46% of persons. The relation of this finding to the symptoms described by the patient, however, is often unclear (1).A 42-year-old man being seen for headaches mentioned during the consultation that he had had a problem with his left arm. When he turned his head to the right and positioned his left arm, he had parasthesiae in the medial...References1. RainsRitchie AH. Bailey and Love's Short Practice of Surgery. London: H.K. Lewis and Co. Ltd.; 1977. Google Scholar2. Clain A. Hamilton Bailey's Demonstrations of Physical Signs in Clinical Surgery. Bristol: John Wright and Sons Ltd.; 1973. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 February 1989Volume 110, Issue 4Page: 323-323KeywordsRibs Issue Published: 15 February 1989 PDF downloadLoading ...
Doctor is struck off for performing liposuction while suspended from UK medical register
Authors: C. Dyer
Journal: BMJ (2014)

A doctor who continued to perform laser liposuction after he was suspended pending a full fitness to practise hearing has been struck off the UK medical register, being described as “a risk to patient safety.”

Petrus Jooste, who qualified in South Africa, insisted that he did not need medical registration to carry out the procedure. He told the panel at the Medical Practitioners Tribunal Service in Manchester that he could not stay …
Arsenic Cancer Risk Confounder in Southwest Taiwan Data Set
Authors: Steven H. Lamm, Arnold Engel, Cecilia A. Penn, Rusan Chen, Manning Feinleib
Journal: Environmental Health Perspectives (2006)

Quantitative analysis for the risk of human cancer from the ingestion of inorganic arsenic has been based on the reported cancer mortality experience in the blackfoot disease (BFD)–endemic area of southwest Taiwan. Linear regression analysis shows that arsenic as the sole etiologic factor accounts for only 21% of the variance in the village standardized mortality ratios for bladder and lung cancer. A previous study had reported the influence of confounders (township, BFD prevalence, and artesian well dependency) qualitatively, but they have not been introduced into a quantitative assessment. In this six-township study, only three townships (2, 4, and 6) showed a significant positive dose–response relationship with arsenic exposure. The other three townships (0, 3, and 5) demonstrated significant bladder and lung cancer risks that were independent of arsenic exposure. The data for bladder and lung cancer mortality for townships 2, 4, and 6 fit an inverse linear regression model (p < 0.001) with an estimated threshold at 151 μg/L (95% confidence interval, 42 to 229 μg/L). Such a model is consistent with epidemiologic and toxicologic literature for bladder cancer. Exploration of the southwest Taiwan cancer mortality data set has clarified the dose–response relationship with arsenic exposure by separating out township as a confounding factor.
Patients with Acute Poisoning Seen in a General Medical Unit (1960-71)
Authors: A. A. H. Lawson, I. Mitchell
Journal: BMJ (1972)

A review of the 637 out of a total of 941 consecutive cases of acute poisoning admitted to an acute medical unit without special facilities for the treatment of poisoning has shown that despite considerable limitations in the medical, nursing, and laboratory facilities available the results compare favourably with those reported from specialized units.
Fractures of the Hip
Authors: J. Drennan Lowell
Journal: New England Journal of Medicine (1966)

Postoperative ManagementAfter operation the patient will be more comfortable in Russell's traction or balanced suspension with traction than lying free in the bed, and it will be easier for him to move about the bed and to get on and off the bedpan. As soon as he is able to cooperate systematic deep-breathing exercises and coughing should be started to re-expand the lungs and protect him from atelectasis or pneumonia. He should be doing arm, trunk and leg exercises and begin moving the foot, knee and hip on the affected side as quickly as diminishing sensitivity about the fracture . . .
Malpractice — The Statute of Limitations
Authors: Neil L. Chayet
Journal: New England Journal of Medicine (1966)

WITH so much attention being given in legal, medical and lay journals to proof of malpractice claims, it is perhaps wise to look at the statute of limitations, one of the most potent but often misunderstood defenses to the action for malpractice.Nearly all states specify a limited period within which a person must begin a lawsuit. The policy behind such legislation is that there must be a cutoff point to assure orderly presentation and disposition of suits. Also, if too much time elapses before a suit is begun, it becomes extremely difficult to reconstruct what actually occurred and to . . .
Shifting ecologies of malignant and nonmalignant cells following BRAF inhibition
Authors: Catherine J. Wu
Journal: Journal of Clinical Investigation (2014)

Clinical vignette: A 49-year-old man with stage IV BRAFV600E-driven melanoma was initiated on twice-daily 960 mg of vemurafenib for treatment of progressive and recurrent subcutaneous metastatic disease of the left lower extremity. The patient's melanoma responded well to targeted BRAF inhibition. At treatment onset, hematologic parameters were all within normal limits; however, within three months of initiating therapy, wbc were found to be elevated (to 20 K) with sustained lymphocytosis of mature phenotype. Immunophenotypic analysis was consistent with chronic lymphocytic leukemia (CLL), and FISH results revealed presence of the CLL-associated deletion in chromosome 13q14 as well as in 2p33. Vemurafenib was withdrawn after approximately one year of therapy, and subsequently, his peripheral lymphocytosis resolved and CLL regressed. Nevertheless, a monoclonal B cell population persisted even 732 days after discontinuation of vemurafenib.
Antibodies to the Physiochemical-Consensus Sequence of Jug r 2 Containing Glutamine-Rich Repeats Bind Allergens in Peanuts and Other Tree Nuts
Authors: Catherine Schein, Suzanne S. Teuber, Hsiaopo Cheng, Casey C. Grimm, Soheila J. Maleki
Journal: Journal of Allergy and Clinical Immunology (2013)