tbuckley/cabot-search huggingface dataset:
Depression of erythropoiesis with methyldopa.
Authors: J. C. Devlin
Journal: BMJ (1965)

BRmIISHas in the white.3This shows that the diagnosis of varicose veins under the dark skin cannot long continue in doubt.I assume that a fair number of cases of varicose veins occur in Ghana, and I should be somewhat disconcerted if this were not the case.In a forthcoming work Dr. G. D. Campbell and myself advance the view that varicose veins are part of a much more com- prehensive disease, which includes such con- ditions as dental caries, peptic ulcer, and diabetes, all due to the consumption of refined carbohydrates.It is therefore highly relevant that the late Professor A. A. MacGregor, in his 1964 report of a survey on dental dis- ease in Ghana,4 was able to correlate very closely the presence of dental caries with the consumption of these foods-so it would be surprising, on this view, if there were not already cases of varicose veins in the Ghanaians.If not, I am afraid there soon will be, and I fear they will not long remain only " clinical impressions."-Iam, etc.,
SIRT1 prevents genotoxic stress-induced p53 activation in acute myeloid leukemia
Authors: Daniel Sasca, Patricia S. Hähnel, Jakub Szybinski, Kaml Khawaja, Oliver Kriege, Saskia V. Pante, Lars Bullinger, Susanne Strand, Dennis Strand, Matthias Theobald, Thomas Kindler
Journal: Blood (2014)
Government distorted research on reforms to disability benefit, says campaign group
Authors: N. Hawkes
Journal: BMJ (2012)

As the Welfare Reform Bill reaches its final stages in the House of Lords, a campaign group has published a report that is strongly critical of the proposed changes to Disability Living Allowance in the bill.

It says that the government misrepresented the results of its consultation on the changes and has exaggerated rises in the cost of the allowance, which will be replaced by a new benefit, Personal Independence Payments, if the bill becomes law. The consultation was itself flawed, the report says, because it lasted only 10 weeks, not the 12 recommended in the code of practice, and the bill was presented to parliament two days before the consultation ended, meaning that not all submissions could have been taken into …
Practical Pathological Work
Authors: H. A. Reeves
Journal: BMJ (1883)

<h3>Abstract</h3> Advanced practice providers (APPs) are qualified medically licensed health care providers, including nurse practitioners (NPs), physician assistants (PAs), nurse anesthetists, certified nurse-midwives, and clinical nurse specialists, who can function either independently or alongside a physician in population-centered care models, disease management integration, care coordination, or in the provision of direct patient care. They also can improve revenue and reduce physician burnout. The use of APPs in the practice of neurology is still in its infancy, and many neurologists are not sure how to integrate an APP in their practice. This article addresses some concerns related to integrating an APP in the inpatient and outpatient settings.
DAILY WEATHER AND THE OCCURRENCE OF ACUTE MYOCARDIAL INFARCTION
Authors: Kyohei Yamaji, Shun Kohsaka, Kenshi Fujii, Shinsuke Nanto, Osamu Iida, Takatoshi Hayashi, Shigeru Nakamura, Satoru Sumitsuji, Takashi Akasaka, Takeshi Kimura
Journal: Journal of the American College of Cardiology (2014)
Feed your head
Authors: T. Delamothe
Journal: BMJ (1998)

More than 100 people have so far responded to our request for suggestions for books to broaden the horizons of doctors and medical students. We started the ball rolling in last year's Christmas issue by publishing 28 invited selections from a motley assortment of BMJ readers (20-27 December 1997, p 1712). Since then another 76 readers have sent us their lists: 57 submitted directly to our internet website, 19 by more traditional means.

Special programming of the website allowed a league table to be assembled “on the fly,” changing as each new set of recommendations was added. Readers were asked …
Nursing Home Antipsychotics
Authors: Mike Mitka
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Estimated Exposure to Arsenic in Breastfed and Formula-Fed Infants in a United States Cohort
Authors: Courtney C. Carignan, Kathryn L. Cottingham, Brian P. Jackson, Shohreh F. Farzan, A. Jay Gandolfi, Tracy Punshon, Carol L. Folt, Margaret R. Karagas
Journal: Environmental Health Perspectives (2015)

Background: Previous studies indicate that concentrations of arsenic in breast milk are relatively low even in areas with high drinking-water arsenic. However, it is uncertain whether breastfeeding leads to reduced infant exposure to arsenic in regions with lower arsenic concentrations.Objective: We estimated the relative contributions of breast milk and formula to arsenic exposure during early infancy in a U.S. population.Methods: We measured arsenic in home tap water (n = 874), urine from 6-week-old infants (n = 72), and breast milk from mothers (n = 9) enrolled in the New Hampshire Birth Cohort Study (NHBCS) using inductively coupled plasma mass spectrometry. Using data from a 3-day food diary, we compared urinary arsenic across infant feeding types and developed predictive exposure models to estimate daily arsenic intake from breast milk and formula.Results: Urinary arsenic concentrations were generally low (median, 0.17 μg/L; maximum, 2.9 μg/L) but 7.5 times higher for infants fed exclusively with formula than for infants fed exclusively with breast milk (β = 2.02; 95% CI: 1.21, 2.83; p < 0.0001, adjusted for specific gravity). Similarly, the median estimated daily arsenic intake by NHBCS infants was 5.5 times higher for formula-fed infants (0.22 μg/kg/day) than for breastfed infants (0.04 μg/kg/day). Given median arsenic concentrations measured in NHBCS tap water and previously published for formula powder, formula powder was estimated to account for ~ 70% of median exposure among formula-fed NHBCS infants.Conclusions: Our findings suggest that breastfed infants have lower arsenic exposure than formula-fed infants, and that both formula powder and drinking water can be sources of exposure for U.S. infants.Citation: Carignan CC, Cottingham KL, Jackson BP, Farzan SF, Gandolfi AJ, Punshon T, Folt CL, Karagas MR. 2015. Estimated exposure to arsenic in breastfed and formula-fed infants in a United States cohort. Environ Health Perspect 123:500–506; http://dx.doi.org/10.1289/ehp.1408789
Syringe and Needle Exchange to Prevent HIV Infection
Authors: Daniel Fernando
Journal: JAMA (1994)

To the Editor.  —Two recent articles 1,2 argue that needle-exchange programs (NEPs) are an effective human immunodeficiency virus (HIV) control strategy among injecting drug users (IDUs). Driven by the failure of current policies and European successes, NEPs have become the focus of US policy discussion, as demonstrated by the General Accounting Office report, 3 the congressional allocation of $5 million to evaluate NEPs (PL 102-321, July 10,1992), and a flurry of publications and conferences. Therefore, it is critical to underline the limitations and move the policy debate beyond NEPs.  Injecting drug users are forced to use dirty needles because of scarcity, higher prices, and fear of carrying needles, generated by restrictive policies and criminalization of paraphernalia possession. Thus, the most effective HIV control strategy is to increase availability through liberal policies as is done in Europe and Australia. Without it, European and American NEPs cannot be compared. Risk reductions attributed
Corticosteroid treatment as a risk factor for invasive aspergillosis in patients with lung disease.
Authors: L. B. Palmer, H. E. Greenberg, M. J. Schiff
Journal: Thorax (1991)

Invasive pulmonary aspergillosis usually occurs in severely immunocompromised or neutropenic patients. Six patients with invasive aspergillosis are described whose only defence impairment was underlying lung disease and corticosteroid treatment. Cough, fever, and sputum production were the usual reasons for presentation and four patients developed the sepsis syndrome. Radiographic findings included de novo cavitation in three patients and rapid radiographic progression in four. Aspergillus species were isolated from respiratory secretions of all patients early in the course of the disease. Treatment was effective in only two patients and the subsequent progress of the others was consistent with a chronic necrotising process. Invasive pulmonary aspergillosis is uncommon in patients with respiratory diseases receiving corticosteroids, but should be considered when pneumonia and cavitary infiltrates occur.
Cost Containment: Another Crusade Begins
Authors: Daniel S. Greenberg
Journal: New England Journal of Medicine (1977)

Hospital cost increases long ago joined the group of things that can't go on like this, but nevertheless do. Now comes the Carter Administration with a pledge to "cap" the process, though it admits it has "no preconceptions of the form such a system might take," apart from the expectation that it will require the services of 125 employees in the Department of Health, Education, and Welfare.Well, the Administration is young, hopeful, and still unweary, and deserves all good wishes in this desirable quest. But the small amount of information that it has released on the tactics that it . . .
Having babies as a surgical trainee
Authors: S. McNally
Journal: BMJ (1999)

Having babies as a surgical traineeHaving a baby in the midst of surgical training posts might seem daunting.Scarlett McNally, a full time specialist registrar in orthopaedic surgery with two children (aged 2 1 /2 years and 8 months), has some advice on 16 July 2023 by guest.
Acid phosphatase staining of the stratum corneum as a marker of damage by low irritancy compounds
Authors: T. RUTHERFORD, A. PAWLOWSKI
Journal: British Journal of Dermatology (1974)

Journal Article Acid phosphatase staining of the stratum corneum as a marker of damage by low irritancy compounds Get access T. RUTHERFORD, T. RUTHERFORD Unilever Research Colworth/Welwyn Laboratory, Sharnbrook, Bedford Search for other works by this author on: Oxford Academic Google Scholar A. PAWLOWSKI A. PAWLOWSKI Unilever Research Colworth/Welwyn Laboratory, Sharnbrook, Bedford Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 91, Issue 5, 1 November 1974, Pages 503–506, https://doi.org/10.1111/j.1365-2133.1974.tb12937.x Published: 01 November 1974 Article history Accepted: 11 April 1974 Published: 01 November 1974
Inhibition of Src Kinase Activity by Ad-mda7 Suppresses Vascular Endothelial Growth Factor Expression in Prostate Carcinoma Cells
Authors: Satoshi Inoue, Cynthia D. Branch, Gary E. Gallick, Sunil Chada, Rajagopal Ramesh
Journal: Molecular Therapy (2005)

The ability of an adenoviral vector expressing the melanoma differentiation-associated gene-7 (Ad-mda7) to mediate inhibition of vascular endothelial growth factor (VEGF) has recently been reported. However, the molecular mechanism by which Ad-mda7 inhibits VEGF is unknown. In an attempt to elucidate this mechanism, we studied the effects of Ad-mda7 on VEGF expression using human prostate cancer cells as a model. We found that Ad-mda7 treatment of prostate cancer cells (LNCaP and DU145) in vitro resulted in a significant (P < 0.05) inhibition of VEGF expression. Analysis of the VEGF signaling pathway showed that Ad-mda7 inhibited c-Src kinase activity and abrogated STAT-3 binding to the VEGF promoter. Correlating with these observations were reductions in VEGF mRNA and protein levels in Ad-mda7-treated cells. Furthermore, Ad-mda7 inhibited VEGF in Src(+/+) but not in Src(-/-) mouse embryo fibroblasts. These results showed that Ad-mda7 inhibited VEGF by inhibiting the Src signaling pathway. Finally, conditioned medium from Ad-mda7-treated tumor cells containing reduced VEGF inhibited VEGF receptor signaling, resulting in reduced endothelial cell proliferation and apoptosis. Our results provide evidence for the mechanism by which Ad-mda7 inhibits VEGF in tumor cells and of the effects of this VEGF inhibition on endothelial cell proliferation, a requirement for angiogenesis. Our findings demonstrate that MDA-7 protein, in addition to inhibiting tumor angiogenesis directly, inhibits angiogenesis indirectly by inhibiting VEGF production by tumor cells.
THE DIAGNOSIS OF DIAPHRAGMATIC HERNIA.
Authors: E. FLETCHER INGALS
Journal: JAMA (1901)

The diagnosis of diaphragmatic hernia presents many difficulties in the living subject; so great indeed are these that the condition is seldom recognized until operation or death has yielded an ocular demonstration. The affection is found in rare cases at autopsies and it is occasionally discovered in the dissecting room in bodies dead of other affections, but all told only a little over 300 cases have been reported. H. I. Bowditch reported a case in 1847 and at that time collected reports of 88 cases. Leichtenstern<sup>1</sup>reported a case in 1874 and at that time collected reports of 250, but only five of these were diagnosticated before death. Thoma<sup>2</sup>collected 290 cases in 1882 and many more have since been reported, but still the obstacles to diagnosis remain, although as shown by Leichtenstern, and by Abel<sup>3</sup>in 1894, there are some cases in which a reasonably positive
Equity in access to total joint replacement of the hip and knee in England: cross sectional study
Authors: A. Judge, N. J. Welton, J. Sandhu, Y. Ben-Shlomo
Journal: BMJ (2010)

<b>Objective</b> To explore geographical and sociodemographic factors associated with variation in equity in access to total hip and knee replacement surgery. <b>Design</b> Combining small area estimates of need and provision to explore equity in access to care. <b>Setting</b> English census wards. <b>Subjects</b> Patients throughout England who needed total hip or knee replacement and numbers who received surgery. <b>Main outcome measures</b> Predicted rates of need (derived from the Somerset and Avon Survey of Health and English Longitudinal Study of Ageing) and provision (derived from the hospital episode statistics database). Equity rate ratios comparing rates of provision relative to need by sociodemographic, hospital, and distance variables. <b>Results</b> For both operations there was an "n" shaped curve by age. Compared with people aged 50-59, those aged 60-84 got more provision relative to need, while those aged ≥85 received less total hip replacement (adjusted rate ratio 0.68, 95% confidence interval 0.65 to 0.72) and less total knee replacement (0.87, 0.82 to 0.93). Compared with women, men received more provision relative to need for total hip replacement (1.08, 1.05 to 1.10) and total knee replacement (1.31, 1.28 to 1.34). Compared with the least deprived, residents in the most deprived areas got less provision relative to need for total hip replacement (0.31, 0.30 to 0.33) and total knee replacement (0.33, 0.31 to 0.34). For total knee replacement, those in urban areas got higher provision relative to need, but for total hip replacement it was highest in villages/isolated areas. For total knee replacement, patients living in non-white areas received more provision relative to need (1.04, 1.00 to 1.07) than those in predominantly white areas, but for total hip replacement there was no effect. Adjustment for hospital characteristics did not attenuate the effects. <b>Conclusions</b> There is evidence of inequity in access to total hip and total knee replacement surgery by age, sex, deprivation, rurality, and ethnicity. Adjustment for hospital and distance did not attenuate these effects. Policy makers should examine factors at the level of patients or primary care to understand the determinants of inequitable provision.
An Address ON BACKACHE IN WOMEN
Authors: H. R. Andrews
Journal: BMJ (1925)

WHEN I started mlakinig a few preliailnary niotes on] the Subject givenl ine by your secretary-iiamelv, backachie in wonien-1 was faced at once by the question: WIas I to attemn)t a scientific and orderly review of all the varieties of baf'-kache, with their causes, diagniosis, anid treatment; or w-as 1 to talk about backachle in a miiuch more informal way, discussing the common causes, the differential dia- gnosis of cases of backache as met with in ordinary every- day practice, pointinig out some of the most likely pitfalls for the uinwary who omit to make as thoro'igh an investigation as they can, and to tell you what treatment I have found most successful?I chose the latter, and hope that I have donie right.Backachle is one of the comnmonest comiiplaints of women; in fact, one lady member of our profeseion has said that women may be divided inlto two classes-namely, women with backs and women without theni.The following is a rough and ready classification of sonme of the causes of backache which will be of some use for our purpose to-day, anid will avoid some needless repetition:Dcfiniite disease or iiijury of some of tile tissues of the back.Fatiguie witlotnt abnormal pliysical signs.Eniter optosis.Abdominial tumotirs.Calrcinioma of the uterus.Caiciniomna of the rectum.Disease or infection of the kidniey.Retroversion of the uterus. Prolapse. Cilonic pelvic inflammation.There is nlotlhliig to prevent a patient froni iavimig at the same time troubles coming under nmore than oile of these headings.This is a very important matter froni thle point of view of treatmiient, and will be referred to later.Disease or Injury of some of the Tissues of the Back.This is a very large class of cases, including amonig others caries of the spine, secondary malignant growths, aortic aneurysm, injury or disease of the sacro-iliac or sacro-coccy-geal joints, bruising or tearing of muscles, etc.This class emiPhasizes the importance, in the diagnosis of
Sputum induction in severe exacerbations of asthma: safety of a modified method
Authors: M.O. Vieira, E. Pizzichini, L.J. Marques Steidle, J. Kadletz da Silva, M.M.M. Pizzichini
Journal: European Respiratory Journal (2011)

To the Editors:

Sputum induction with hypertonic saline is one of the most commonly used and reliable noninvasive methods to examine airway inflammation. The safety of induced sputum has been the subject of many reports focusing on stable asthma of any severity and the procedure is regarded as safe [1]. However, data on safety of induced sputum in acute asthma is limited. In a previous small study, we safely induced sputum in 10 patients with severe exacerbations of asthma using a modified method: starting the induction with isotonic saline, followed by the inhalation of hypertonic saline if necessary [2]. Here, we further examined the safety of this method in a larger number of patients.

The data were obtained from 45 patients (18–60 yrs of age; 29 patients were female, 32 were atopic and 21 were taking inhaled steroids) with asthma previously diagnosed by objective measurements and who were seen for the first visit of another clinical study of moderate-to-severe exacerbations of asthma. A severe exacerbation of asthma was defined as previously described [2]. All patients were either nonsmokers or ex-smokers ( 1 yr. None had other lung diseases. The Research Ethics …
Percutaneous Needle Biopsy of the Lung: A Study of 40 Patients.
Authors: Donald C. Zavala
Journal: Annals of Internal Medicine (1971)

Meeting Abstracts1 May 1971Percutaneous Needle Biopsy of the Lung: A Study of 40 Patients.Donald C. Zavala, M.D., F.A.C.P., George N. Bedell, M.D., F.A.C.P.Donald C. Zavala, M.D., F.A.C.P.Search for more papers by this author, George N. Bedell, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-74-5-841_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThis study was done to determine the diagnostic value and safety of needle lung biopsy. A disposable, modified Vim cutting needle was used. Forty-three of 48 biopsies (90%) performed on 40 patients yielded adequate tissue. Diagnostic success was achieved in 34 (85%) of the patients. The patients were divided into 2 groups, 17 with localized peripheral lung tumors (22 biopsies) and 23 with bilateral diffuse disease (26 biopsies). In the localized disease group the biopsy needle was positioned using a fluoroscopic image amplifier. There were no biopsy failures, but diagnosis was not made in five patients because of tumor necrosis... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Donald C. Zavala, M.D., F.A.C.P.; George N. Bedell, M.D., F.A.C.P.Affiliations: Iowa City, Iowa PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHigh Speed Trephine Lung Biopsy: Methods and Results 1 May 1971Volume 74, Issue 5Page: 841-841KeywordsBiopsyLungsNecrosisSafetySafety studies ePublished: 1 December 2008 Issue Published: 1 May 1971 PDF downloadLoading ...
Rapid expression of heat shock protein in the rabbit after brief cardiac ischemia.
Authors: A A Knowlton, P Brecher, C S Apstein
Journal: Journal of Clinical Investigation (1991)

The effect of brief myocardial ischemia on the expression of heat shock protein (HSP 70) was examined in an in vivo rabbit model of myocardial ischemia using Northern blotting. Functional studies were carried out in the open-chested anesthetized rabbit. The large marginal branch of the left circumflex was occluded four times for 5 min. Using piezoelectric crystals implanted midwall in the ischemic zone, end-diastolic length, end-systolic length, and percent segmental shortening were assessed. Expression of HSP 70 was measured by Northern blotting. A single 5-min coronary occlusion doubled the expression of HSP 70 whereas four cycles of 5 min of ischemia/5 min of reperfusion resulted in a threefold increase in HSP 70 mRNA (P less than 0.001). Measurements with the piezoelectric crystals showed mild myocardial dysfunction concomitant with the increase in HSP 70. This increase in HSP 70 mRNA after repetitive brief ischemia was transient, occurring as early as 1 h and returning to baseline by 24 h after ischemia. Western blot analysis with a monoclonal antibody to HSP 70 was used to compare sham and postischemic myocardial HSP 70 levels. Changes in the amount of HSP 70 were evident as early as 2 h and were even more striking at 24 h.