Functional and Ultrastructural Abnormalities of Platelets in Ehlers-Danlos Syndrome
Authors: HEIHACHIRO KASHIWAGI
Journal: Annals of Internal Medicine (1965)

Article1 August 1965Functional and Ultrastructural Abnormalities of Platelets in Ehlers-Danlos SyndromeHEIHACHIRO KASHIWAGI, M.D., JEANNE M. RIDDLE, PH.D., JOSEPH P. ABRAHAM, M.D., BOY FRAME, M.D., F.A.C.P.HEIHACHIRO KASHIWAGI, M.D., JEANNE M. RIDDLE, PH.D., JOSEPH P. ABRAHAM, M.D., BOY FRAME, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-2-249 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptEhlers-Danlos syndrome is a heritable disorder of connective tissue characterized by hyperelastic, fragile skin and hyperextensible joints (1). The basic defect is thought to be a disturbance of the "wicker-work" of collagen fibers (2).Included among many other features of this condition are easy bruising and hemorrhagic tendency. Indeed, frequent hematoma formation was one of the salient features of the case originally described by Ehlers in 1901 (3). Bleeding may occur at any site and contribute to considerable morbidity. The literature describes cases of gastrointestinal bleeding (4, 5), postpartum bleeding (4), and hematomas simulating hemophilia (3, 6, 7).Despite the...References1. MCKUSICK VA: Heritable Disorders of Connective Tissue, 2nd ed. C. V. Mosby Co., St. Louis, 1960, p. 171. Google Scholar2. JANSEN LH: The structure of the connective tissue: an explanation of the symptoms of Ehlers-Danlos syndrome. Dermatologica 110: 108, 1955. CrossrefMedlineGoogle Scholar3. EHLERS E: Cutis laxa, Neigung zu Haemorrhagien in der Haut, Lockerung mehrerer Artikulationen. Derm. Z. 8: 173, 1901. Google Scholar4. SAMUELSSCHWARTZMEISTER MLMLMM: The Ehlers-Danlos syndrome. U. S. Armed Forces Med. J. 4: 737, 1953. MedlineGoogle Scholar5. JACOBS PH: Ehlers-Danlos syndrome: report of a case with onset at age 29. Arch. Derm. (Chicago) 76: 460, 1957. CrossrefGoogle Scholar6. 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Neurology 14: 125, 1964. CrossrefMedlineGoogle Scholar31. ROBITAILLE GA: Ehlers-Danlos syndrome and recurrent hemoptysis. Ann. Intern. Med. 61: 716, 1964. LinkGoogle Scholar32. BRAUNSTEINERPAKESCH HF: Thromboasthenia and thrombocytopathia—old names and new diseases. Blood 11: 965, 1956. CrossrefMedlineGoogle Scholar33. JOHNSONMONTOCALDWELL SARWMJ: A new approach to thrombocytopathies; thrombocytopathy A. Thromb. Diath. Haemorrh. 2: 279, 1958. MedlineGoogle Scholar34. KASHIWAGIRIDDLECALDWELLABRAHAMFRAME HJMMJJPB: Unpublished data, 1965. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: HEIHACHIRO KASHIWAGI, M.D.; JEANNE M. RIDDLE, PH.D.; JOSEPH P. ABRAHAM, M.D.; BOY FRAME, M.D., F.A.C.P.Affiliations: Detroit, MichiganFrom the Departments of Medicine and Laboratories, Henry Ford Hospital, Detroit, Mich.This paper was presented in part at the Golden Anniversary Session of the American College of Physicians, Chicago, Ill., on March 24, 1965.Requests for reprints should be addressed to Boy Frame, M.D., Henry Ford Hospital, 2799 West Grand Blvd., Detroit, Mich. 48202. 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