Paraneoplastic Autoimmune Xerostomia
Authors: Franco Folli
Journal: Annals of Internal Medicine (1997)

Letters15 July 1997Paraneoplastic Autoimmune XerostomiaFranco Folli, MD, PhD, Maurilio Ponzoni, MD, and Aurelio M. Vicari, MDFranco Folli, MD, PhDIstituto di Ricovero e Cura a Carattere Scientifico; 20132 Milano, ItalySearch for more papers by this author, Maurilio Ponzoni, MDIstituto di Ricovero e Cura a Carattere Scientifico; 20132 Milano, ItalySearch for more papers by this author, and Aurelio M. Vicari, MDIstituto di Ricovero e Cura a Carattere Scientifico; 20132 Milano, ItalySearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-2-199707150-00029 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:An 18-year-old man was hospitalized with intense thirst, polyuria, polydypsia, and weight loss. The oral mucosa appeared slightly dry, and mild hepatosplenomegaly was present. The physical examination was otherwise unremarkable. Diabetes mellitus and insipidus were ruled out by laboratory tests and imaging of the head. Fever and pancytopenia, in the absence of signs of disease other than xerostomia, prompted us to take a biopsy specimen from the bone marrow. Lymphoblastic lymphoma was diagnosed, polychemotherapy produced complete remission, and xerostomia disappeared. Two relapses were heralded by xerostomia that disappeared after remission was obtained through salvage protocols. The patient ...References1. Moutsopolous HM. Sjogren's syndrome. In: Isselbacher KJ, Braunwald E, Wilson JD, Martin JB, Fauci AS, Kasper DL, eds. Harrison's Principles of Internal Medicine. 13th ed. New York: McGraw-Hill; 1994:1661-4. Google Scholar2. Agarwala SS. Paraneoplastic syndromes. Med Clin North Am. 1996; 80:173-84. Google Scholar3. Lennon VA, Lambert EH. Autoantibodies bind solubilized calcium channel-omega conotoxin complexes from small cell lung carcinoma: a diagnostic aid for Lambert-Eaton myastenic syndrome. Mayo Clin Proc. 1989; 64:1498-553. Google Scholar4. Posner JB. Parancoplastic syndromes. Neurol Clin. 1991; 9:919-36. Google Scholar5. Folli F, Solimena M, Cofiell R, Austoni M, Tallini G, Fassetta G, et al. Autoantibodies to a 128-kd synaptic protein in three women with the stiff-man syndrome and breast cancer, N Engl J Med. 1993; 328:546-51. Google Scholar Author, Article, and Disclosure InformationAuthors: Franco Folli, MD, PhD; Maurilio Ponzoni, MD; Aurelio M. Vicari, MDAffiliations: Istituto di Ricovero e Cura a Carattere Scientifico; 20132 Milano, Italy PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCancer-/Cancer Treatment-Related Salivary Gland DysfunctionSalivary gland dysfunction (‘dry mouth’) in patients with cancer: a consensus statement 15 July 1997Volume 127, Issue 2Page: 167-168KeywordsAutoantibodiesMucous membranesParotid glandsPathogensPneumoniaPrecursor cellsSalivary gland tumorsSalivary glandsSjogren syndromeWeight loss ePublished: 15 August 2000 Issue Published: 15 July 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...