Plasma Fibrinogen in Familial Mediterranean Fever
Authors: ASHER FRENSDORFF
Journal: Annals of Internal Medicine (1961)

Article1 September 1961Plasma Fibrinogen in Familial Mediterranean FeverASHER FRENSDORFF, M.D., EZRA SOHAR, M.D., HARRY HELLER, M.D.ASHER FRENSDORFF, M.D.Search for more papers by this author, EZRA SOHAR, M.D.Search for more papers by this author, HARRY HELLER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-55-3-448 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA rise in the plasma fibrinogen level is a nonspecific body response which occurs in many pathological states, resembling in this respect an increase in the erythrocyte sedimentation rate. Indeed, the fibrinogen level is one of the principal factors influencing the erythrocyte sedimentation rate (1). Little is known of the mechanism which controls the fibrinogen level in health and disease, or of the possible functions of fibrinogen other than its role in blood clotting. The possibility of qualitative differences in the fibrinogen in various disorders has hardly been explored, most studies having been concerned only with quantitative aspects.Sometimes the...References1. WUHRMANWUNDERLY FC: Die Bluteiweisskörper des Menschen, Benno Schwabe & Co., Basel, 1957. Google Scholar2. SCHULTZ FH: Das Fibrinogen, Georg Thieme Verlag, Leipzig, 1953. Google Scholar3. STARLINGERWINANDS WE: Uber das Verteilungsverhältnis der zirkulierenden Eiweisskörper in Verlauf Krankhäfter Zustande. Z. Exp. Med. 60: 138, 1928. CrossrefGoogle Scholar4. SPITZER JM: Fibrinogen concentration in pulmonary diseases. New York J. Med. 59: 3242, 1959. MedlineGoogle Scholar5. FRENSDORFFSOHARHELLER AEH: Unpublished data. Google Scholar6. HUNTTREW TEJA: Zone electrophoretic studies of plasma proteins in rheumatoid arthritis and ankylosing spondylitis. Ann. Rheum. Dis. 13: 201, 1954. CrossrefMedlineGoogle Scholar7. LOSADAZAŃARTUATRIAETCHEVERRYCONCHAACEVEDO MJAREH: Laboratory findings in rheumatoid arthritis. Rev. Clin. Esp. 50: 203, 1953. MedlineGoogle Scholar8. FLETCHERDAUPHINEEOGRYZLO AJAMA: Plasma fibrinogen and erythrocyte sedimentation rate in rheumatoid arthritis and their response to the administration of cortisone and ACTH. J. Clin. Invest. 31: 561, 1952. CrossrefMedlineGoogle Scholar9. LINKOWARIS EE: Serum mucoproteins and fibrinogen content in acute myocardial infarction. Scand. J. Clin. Lab. Invest. 7: 141, 1955. CrossrefMedlineGoogle Scholar10. LINKOWARISALIKOSKI EEHA: Plasma protein changes and their influence on the erythrocyte sedimentation rate in myocardial infarction. Acta Med. Scand. 153: 359, 1956. Google Scholar11. LOSNERVOLKWILENSKY SBWN: Fibrinogen concentration in acute myocardial infarction. Arch. Intern. Med. 93: 231, 1954. CrossrefGoogle Scholar12. VOLKLOSNERCRASTROPOL BWSP: The clot density method of determination of fibrinogen in acute myocardial infarction. Bull. N. Y. Acad. Med. 32: 244, 1956. MedlineGoogle Scholar13. MADSEN H: Plasma fibrinogen and erythrocyte sedimentation rate in myocardial infarction. Acta Med. Scand. 156: 351, 1957. CrossrefMedlineGoogle Scholar14. GILCHRISTTULLOCK EJA: Plasma fibrinogen content after myocardial infarction. Edinburgh Med. J. 59: 561, 1952. MedlineGoogle Scholar15. SOHARHELLERPRASHELLER EJMH: Genetics of familial Mediterranean fever (FMF). Arch. Intern. Med. 107: 529, 1961. CrossrefGoogle Scholar16. HELLERSOHARSHERF HEL: Familial Mediterranean fever. Arch. Intern. Med. 102: 50, 1958. CrossrefGoogle Scholar17. HIRSCHCATTANEO AC: Fibrogen behavior in tuberculosis. Electrophoretic research in plasma. Chem. Abst. 50: 8874 b, 1956. Google Scholar18. PATIOLARACKOLLIO RT: The lipid content and the electrophoretic determination of protein composition of serum and the fibrinogen content of plasma in leprosy. Ann. Med. Exp. Fenn. 29: 335, 1951. Google Scholar19. HELLERSOHARGAFNIHELLER HEJJ: Amyloidosis in familial Mediterranean fever (FMF). Arch. Intern. Med. 107: 359, 1961. CrossrefGoogle Scholar20. COHENCALKINS ASE: Electronmicroscopic observations on a fibrous component in amyloid of diverse origins. Nature 183: 1202, 1959. CrossrefMedlineGoogle Scholar21. COHENCALKINS ASE: A study of the fine structure of the kidney in casein-induced amyloidosis in rabbits. J. Exp. Med. 112: 479, 1960. CrossrefMedlineGoogle Scholar22. GRAM HC: A new method for the determination of the fibrin percentage in blood and plasma. J. Biol. Chem. 49: 279, 1921. CrossrefGoogle Scholar23. MIZUTA W: Determination of plasma fibrinogen by the biuret reagent. Chem. Abst. 48: 2810 e, 1954. Google Scholar24. RAPPAPORTLOEW FM: A stable standard for the colorimetric determination of total proteins, albumin, globulin and fibrinogen. Clin. Chim. Acta 2: 126, 1957. CrossrefMedlineGoogle Scholar25. JACOBSON K: Studies on the determination of fibrinogen in human blood plasma. Scand. J. Clin. Lab. Invest., Supp. 14, Vol. 7, 1955. Google Scholar26. PERSSON I: Normal values for plasma fibrinogen in the age group 20-50. Scand J. Clin. Lab. Invest. 7: 279, 1955. CrossrefMedlineGoogle Scholar27. POPOVSTANISHEVA NS: Erythrocyte sedimentation rate, C-reactive protein, serum protein fractions, fibrinogen level and antistreptolysin titer in 52 rheumatic children. Arch. Dis. Child. 33: 529, 1958. CrossrefMedlineGoogle Scholar28. WESTERGRENTHEORELLWIDSTROM AHG: Plasmaeiweiss, Blutlipoide, Erythrocyten und Senkungsreaktion. Z. Exp. Med. 75: 668, 1931. CrossrefGoogle Scholar29. JACKSONKELLYKNAPP-SMITHWANGROUTH RLHGEPJI: Electrophoretic analyses of plasma or serum proteins of rheumatic fever patients in relation to stages of disease. Amer. J. Dis. Child. 86: 403, 1953. Google Scholar30. SHINOWARAWAITESALEEBY GYJHR: Plasma coagulation factors in acute pancreatitis. Proc. Soc. Exp. Biol. Med. 83: 426, 1953. CrossrefMedlineGoogle Scholar31. FENDELGEROK HW: Die Fibrinkonzentration im Blutplasma während einer experimental erzeugten Entzündung mit und ohne Amyloidose. Virchow. Arch. Path. Anat. 327: 314, 1955. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ASHER FRENSDORFF, M.D.; EZRA SOHAR, M.D.; HARRY HELLER, M.D.Affiliations: Tel Aviv,Received for publication December 22, 1960.From the Department of Medicine, FMF Unit, Tel-Hashomer Hospital, Tel Aviv, Israel.This study was supported in part by research grant A-2857 from the U. S. Public Health Service, National Institutes of Health, Bethesda, Md.Requests for reprints should be addressed to Harry Heller, M.D., Department of Medicine, Tel-Hashomer Hospital, Tel Aviv, Israel. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEvaluation of the Mean Platelet Volume and Red Cell Distribution Width in FMF: Are They Related to Subclinical Inflammation or Not?Can Serum Fetuin-A Be Regarded as an Inflammatory Marker Among Patients with Familial Mediterranean Fever?Recent advances in the management of children with familial Mediterranean feverNeurologic and other systemic manifestations in FMF: Published and own experienceChronic inflammation in FMF: markers, risk factors, outcomes and therapyFamilial Mediterranean feverDiagnostic and treatment concerns in familial Mediterranean feverThe changing face of Familial Mediterranean FeverThe Effect of SAA-Derived Fragment — SAA2–82 — On Platelet AggregationRenal hyalin: A study of amyloidosis and diabetic fibrinous vasculosis with new staining methodsIntestinal obstruction complicating familial Mediterranean feverRole of fibrinogen (fibrin) in amyloid formation in experimental amyloidosisAmyloidosisFamilial Mediterranean feverPeriodic DiseasePlasma proteins in familial mediterranean feverFamilial paroxysmal polyserositis 1 September 1961Volume 55, Issue 3Page: 448-455KeywordsAmyloidosisBlood plasmaErythrocyte sedimentation rateFibrinogenHospital medicinePlasma proteinsProteinuriaQualitative studiesResearch grantsThorax ePublished: 1 December 2008 Issue Published: 1 September 1961 PDF downloadLoading ...