tbuckley/cabot-search huggingface dataset:
Bone marrow deficiency of TRPC3 channel reduces early lesion burden and necrotic core of advanced plaques in a mouse model of atherosclerosis
Authors: Jean-Yves Tano, Sumeet Solanki, Robert H. Lee, Kathryn Smedlund, Lutz Birnbaumer, Guillermo Vazquez
Journal: Cardiovascular Research (2013)

AimsMacrophage apoptosis plays a determinant role in progression of atherosclerotic lesions. An important goal in atherosclerosis research is to identify new components of macrophage apoptosis that can eventually be exploited as molecular targets in strategies aimed at manipulating macrophage function in the lesion. In the previous work from our laboratory, we have shown that transient receptor potential canonical 3 (TRPC3) channel is an obligatory component of survival mechanisms in human and murine macrophages and that TRPC3-deficient non-polarized bone marrow-derived macrophages exhibit increased apoptosis, suggesting that in vivo TRPC3 might influence lesion development. In the present work, we used a bone marrow transplantation strategy as a first approach to examine the impact of macrophage deficiency of TRPC3 on early and advanced atherosclerotic lesions of Apoe−/− mice.
Chronic campylobacter colitis and uveitis in patient with hypogammaglobulinaemia.
Authors: A M Lever, J M Dolby, A D Webster, A B Price
Journal: BMJ (1984)

Chronic campylobacter colitis and uveitis in patient with hypogammaglobulinaemiaCampylobacter jejuni and coli are recognised causes of enteritis, and self limiting diarrhoea is a common symptom.' Occasionally the disease resembles Crohn's disease and ulcerative colitis.Chronic infection occurs rarely but has been reported in children and patients with immunodeficiency.2We report on a patient with immunodeficiency with chronic diarrhoea in whom C jejuni was repeatedly isolated and acute anterior uveitis occurred.Case report 'Price AB, Day DW.Pseudomembranous and infectious colitis.
Stat5 Synergizes with T Cell Receptor/Antigen Stimulation in the Development of Lymphoblastic Lymphoma
Authors: John A. Kelly, Rosanne Spolski, Panu E. Kovanen, Takeshi Suzuki, Julie Bollenbacher, Cynthia A. Pise-Masison, Michael F. Radonovich, Stephen Lee, Nancy A. Jenkins, Neal G. Copeland, Herbert C. Morse, Warren J. Leonard
Journal: The Journal of Experimental Medicine (2003)

Signal transducer and activator of transcription (STAT) proteins are latent transcription factors that mediate a wide range of actions induced by cytokines, interferons, and growth factors. We now report the development of thymic T cell lymphoblastic lymphomas in transgenic mice in which Stat5a or Stat5b is overexpressed within the lymphoid compartment. The rate of lymphoma induction was markedly enhanced by immunization or by the introduction of TCR transgenes. Remarkably, the Stat5 transgene potently induced development of CD8+ T cells, even in mice expressing a class II-restricted TCR transgene, with resulting CD8+ T cell lymphomas. These data demonstrate the oncogenic potential of dysregulated expression of a STAT protein that is not constitutively activated, and that TCR stimulation can contribute to this process.
Repetitive hair pulling associated with schizophrenia
Authors: None Tsai, None Chang
Journal: British Journal of Dermatology (1998)

Journal Article Repetitive hair pulling associated with schizophrenia Get access Tsai, Tsai Department of Psychiatry, Veterans General Hospital‐Taipei, No. 201, Shih‐Pai Road Sec. 2, Taipei, Taiwan,Division of Neuropsychiatry, School of Medicine, National Yang‐Ming University, Taipei, Taiwan Search for other works by this author on: Oxford Academic Google Scholar Chang Chang Department of Psychiatry, Veterans General Hospital‐Taipei, No. 201, Shih‐Pai Road Sec. 2, Taipei, Taiwan, Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 138, Issue 6, 1 June 1998, Pages 1095–1096, https://doi.org/10.1046/j.1365-2133.1998.02291.x Published: 01 June 1998
Ticlopidine and Thrombotic Thrombocytopenic Purpura
Authors: Yizhak Kupfer, Sidney Tessler
Journal: New England Journal of Medicine (1997)

To the Editor: Ticlopidine hydrochloride (Ticlid) is a potent platelet-antiaggregating agent that has been used in the United States since 1991 to reduce the risk of thrombotic stroke in patients with aspirin intolerance. Recently, it has been demonstrated to decrease the incidence of cardiac events and reocclusion after the placement of a coronary-artery stent.1 We report two cases of fulminant thrombotic thrombocytopenic purpura that developed within three weeks of the initiation of ticlopidine therapy after coronary-stent placement. A 47-year-old woman presented in September 1996 with a 48-hour history of increasing confusion, icterus, and nausea. Three weeks before admission she had . . .
A Post-Sclerotherapy Complication: Intramural Hematoma of the Esophagus
Authors: P. Brosolo, R. Maieron, G. L. Da Broi
Journal: Endoscopy (1993)

See also: Intramural Hematoma of the Esophagus after Variceal SclerotherapyEndoscopy 1991; 23(05): 299-301DOI: 10.1055/s-2007-1010694
Epithelial–Mesenchymal Transitioned Circulating Tumor Cells Capture for Detecting Tumor Progression
Authors: Arun Satelli, Abhisek Mitra, Zachary Brownlee, Xueqing Xia, Seth Bellister, Michael J. Overman, Scott Kopetz, Lee M. Ellis, Qing H. Meng, Shulin Li
Journal: Clinical Cancer Research (2014)

Abstract Purpose: This study aimed to detect cell-surface vimentin (CSV) on the surface of epithelial–mesenchymal transitioned (EMT) circulating tumor cells (CTC) from blood of patients with epithelial cancers. Experimental Design: In this study, 101 patients undergoing postsurgery adjuvant chemotherapy for metastatic colon cancer were recruited. EMT CTCs were detected from blood of patients using the 84-1 monoclonal antibody against CSV as a marker. EMT CTCs isolated were characterized further using EMT-specific markers, fluorescent in situ hybridization, and single-cell mutation analysis. Results: Using the 84-1 antibody, we detected CSV exclusively on EMT CTCs from a variety of tumor types but not in the surrounding normal cells in the blood. The antibody exhibited very high specificity and sensitivity toward different epithelial cancer cells. With this antibody, we detected and enumerated EMT CTCs from patients. From our observations, we defined a cutoff of &amp;lt;5 or ≥5 EMT CTCs as the optimal threshold with respect to therapeutic response using ROC curves. Using this defined threshold, the presence of ≥5 EMT CTCs was associated with progressive disease, whereas patients with &amp;lt;5 EMT CTCs showed therapeutic response. Conclusion: Taken together, the number of EMT CTCs detected correlated with the therapeutic outcome of the disease. These results establish CSV as a universal marker for EMT CTCs from a wide variety of tumor types and thus provide the foundation for emerging CTC detection technologies and for studying the molecular regulation of these EMT CTCs. Clin Cancer Res; 21(4); 899–906. ©2014 AACR.
THE ACTION OF IMMUNE SERUM ON HUMAN INFLUENZA VIRUS IN VITRO
Authors: T. P. Magill, Thomas Francis
Journal: The Journal of Experimental Medicine (1937)

Studies have been conducted on the effect of immune serum upon a strain of human influenza virus (PR8) grown in chick embryo tissue culture medium. The results have demonstrated (a) that when cells are exposed to the action of immune serum of high titer and subsequently washed freely, these cells support the growth of virus as well as cells treated with normal serum; (b) that, in agreement with the results of other workers, when virus is added to cell suspensions before the addition of immune serum of low titer, virus survives in the cells; (c) that when mixtures of immune serum of low titer and virus are added to cells, there is little evidence of survival or multiplication of the virus. Furthermore, when immune serum of high titer is used the virus is inactivated regardless of whether the cells are first exposed to virus or immune serum. Finally, virus mixed with a strong immune serum is inactivated in the absence of cells, as shown by the fact that centrifugation at high speeds of such serum-virus mixtures yields no active virus, whereas normal serum-virus mixtures yield fully active virus.
HTLV-1 infection: role of CTL efficiency
Authors: Charles R. M. Bangham
Journal: Blood (2008)

Phenotypic examination by Sabouri and colleagues of CD8+ T cells in HTLV-1–infected people supports genetic and immunologic evidence that an inefficient CTL response to HTLV-1 results in a high proviral load and the inflammatory disease HAM/TSP.

In addition to causing the aggressive CD4+ T-cell
Ceruletide in Postoperative Adynamic Ileus-Reply
Authors: Ruedi F. Thoeni
Journal: JAMA (1982)

ABSTRACT In Reply.— We appreciate the comments made by Drs Vincent and Robbins regarding the use of ceruletide (Tymtran)  postoperative adynamic ileus. Their remarks are correct. By error, the words in the United States were inadvertently dropped from the sentence  question. We are well aware of the publications cited, and at the University of California, San Francisco, a research study has investigated the use of ceruletide  dogs with adynamic ileus following abdominal surgery. These data have not yet been published, but appear to confirm observations made by other investigators  foreign countries. However, despite many studies from other countries that provide ample evidence of restoration of intestinal peristalsis following injection of ceruletide  patients with postoperative adynamic ileus, as well as evidence of good tolerance of the drug  patients, labeling recommendations for the use of ceruletide  these patients is not approved by the Food and Drug
ABC of 1 to 7 (revised). Recurrent headache.
Authors: H B Valman
Journal: BMJ (1987)

RECURRENT HEADACHEAny acute illness with pyrexia may cause headache, but if there is drowsiniess,' vomiting, photophobia, neck stiffness, or purpura an emergency lumbar puncture needs to be considered to exclude meningitis.Recurrent -headaches are due to migraine, emotional -Migraine tension, muscle contraction, or intracranial pathology.Emotional factors may precipitate attacks of migraine.Muscle contraction Emotional tension headaches occur if there is repeated clenching or grinding of the teeth.0 Muscle contraction Detailed physical examination is essential on the first visit, and reassessment is needed during the first six months after the onset of Intracranial pathology headaches to'exclude a cerebral tumour which did not produce localisng symptoms or signs initially.The blood pressure should be measured and the fundi examined in every child with headache.Migraine occurs in about 4% of children, and tension headaches probably have about the same incidence.
Cancer Research UK will increase its research spending by 50% over the next five to 10 years
Authors: I. Torjesen
Journal: BMJ (2014)

<h3>Background</h3> TRPC6 is a nonselective cation channel, and mutations of this gene are associated with FSGS. These mutations are associated with TRPC6 current amplitude amplification and/or delay of the channel inactivation (gain-of-function phenotype). However, the mechanism of the gain-of-function in TRPC6 activity has not yet been clearly solved. <h3>Methods</h3> We performed electrophysiologic, biochemical, and biophysical experiments to elucidate the molecular mechanism underlying calmodulin (CaM)-mediated Ca<sup>2+</sup>-dependent inactivation (CDI) of TRPC6. To address the pathophysiologic contribution of CDI, we assessed the actin filament organization in cultured mouse podocytes. <h3>Results</h3> Both lobes of CaM helped induce CDI. Moreover, CaM binding to the TRPC6 CaM-binding domain (CBD) was Ca<sup>2+</sup>-dependent and exhibited a 1:2 (CaM/CBD) stoichiometry. The TRPC6 coiled-coil assembly, which brought two CBDs into adequate proximity, was essential for CDI. Deletion of the coiled-coil slowed CDI of TRPC6, indicating that the coiled-coil assembly configures both lobes of CaM binding on two CBDs to induce normal CDI. The FSGS-associated TRPC6 mutations within the coiled-coil severely delayed CDI and often increased TRPC6 current amplitudes. In cultured mouse podocytes, FSGS-associated channels and CaM mutations led to sustained Ca<sup>2+</sup> elevations and a disorganized cytoskeleton. <h3>Conclusions</h3> The gain-of-function mechanism found in FSGS-causing mutations in TRPC6 can be explained by impairments of the CDI, caused by disruptions of TRPC’s coiled-coil assembly which is essential for CaM binding. The resulting excess Ca<sup>2+</sup> may contribute to structural damage in the podocytes.
UK exceeds target on mortality from elective repair of abdominal aneurysm four years early
Authors: Z. Kmietowicz
Journal: BMJ (2012)

Deaths after elective surgery for abdominal aortic aneurysm have plummeted in the United Kingdom from 7.9% in 2008 to 2.4% (197 deaths among 8380 patients treated) in 2009-10, shows the first ever national audit of the procedure.

However, there is much variation among the 127 units across the country that took part in the audit. While some report no deaths among the patients they treated between 1 October 2008 and 30 September 2010, others have mortality rates in the high teens.

The highest mortality rate was at Sherwood Forest Hospitals NHS Foundation Trust, which recorded a rate of 20% (three of 15 patients died).

However, the Vascular Society, which compiled the report, cautions that the data were …
Cholesterol synthesis is increased and absorption decreased in non-alcoholic fatty liver disease independent of obesity
Authors: Piia Simonen, Anna Kotronen, Maarit Hallikainen, Ksenia Sevastianova, Janne Makkonen, Antti Hakkarainen, Nina Lundbom, Tatu A. Miettinen, Helena Gylling, Hannele Yki-Järvinen
Journal: Journal of Hepatology (2010)
Transmyocardial Laser Revascularization
Authors: R. A. Lange, L. D. Hillis
Journal: New England Journal of Medicine (1999)

To perform transmyocardial laser revascularization, the surgeon exposes the beating heart through a lateral thoracotomy, places a laser (carbon dioxide or holmium) on the epicardial surface of the left ventricle, and applies sufficient energy to create small channels from the epicardial to the endocardial surfaces. During a typical procedure, 10 to 50 such channels are created. Initially, these small, laser-created transmyocardial channels were thought to improve the perfusion of ischemic myocardium by providing it with direct access to oxygen-rich left ventricular blood, but it was subsequently found that the channels quickly occlude after the procedure.1 Nonetheless, initial observational studies of . . .
PU.1 is a major downstream target of AML1 (RUNX1) in adult mouse hematopoiesis
Authors: Gang Huang, Pu Zhang, Hideyo Hirai, Shannon Elf, Xiaomei Yan, Zhao Chen, Steffen Koschmieder, Yutaka Okuno, Tajhal Dayaram, Joseph D Growney, Ramesh A Shivdasani, D Gary Gilliland, Nancy A Speck, Stephen D Nimer, Daniel G Tenen
Journal: Nature Genetics (2007)
KELOID FOLLOWING TRAUMATISM.
Authors: W. M. COLE
Journal: JAMA (1901)

Keloid, a term first applied by Alibert in the year 1814, to a pathologic condition known as an overgrowth of scar tissue, was so named by reason of its resemblance to a crab. The term is also applied to apparent fibrous outgrowths of the skin of a similar character, formerly believeed to be of spontaneous origin, but now the theory is accepted that they are results of lesions in the skin. This is said by some authors to be a somewhat rare disease and affects the colored races more than the white. It is commonest in middle age, but may occur in any age of life. Its favorite sites are the anterior superior sternal region, the shoulders and the neck, but may occur on any part of the body. The so-called keloid of Addison forms contractions of the skin and the fasciæ, thus giving a hide-bound appearance to the part.
Wings — A Neurologist at the Theater
Authors: Norman Geschwind
Journal: New England Journal of Medicine (1979)

Although there are well known representations of disease in fiction it is surprising to discover how rare it has been for illness, which is so common an affliction of humanity, to be of central importance in literary works. Notable examples rapidly come to mind. Thomas Mann made use of disease as a central theme at least twice, in his novel Magic Mountain and again in Death in Venice. Dostoievskii wove his own seizures into the fabric of his writings, and every one of his long novels, with the exception of Crime and Punishment, contains a character suffering from . . .
IODIZED POPPY-SEED OIL IN VENOUS SYSTEM
Authors: S. Leon Israel
Journal: JAMA (1935)

<h3>To the Editor:—</h3> The instructive and interesting case report by Dr. Geza Weitzner (The Journal, February 16, p. 545), wherein is described accidental escape of iodized poppy-seed oil into the venous system of the uterus during the course of an intra-uterine injection, suggests the following comments: In an attempt to explain the etiology of such accidental venous roentgenograms, Dr. Weitzner rejects the possibilities of "excessive pressure during the injection" and "pathologic permeability of the uterine vessels" in favor of the theory that supposes the presence of "injury to the uterine wall" with probable invasion of the venous sinuses. The latter mechanism is substantiated, in the case of Dr. Weitzner's patient, by the report of vaginal bleeding during four days immediately following the uterine manipulation. More direct evidence for such an explanation was given by Dr. John A. Sampson before the forty-third annual meeting of the American Gynecological Association on May
Exposure to pets and atopy‐related diseases in the first 4 years of life
Authors: P. Nafstad, P. Magnus, P. I. Gaarder, J. J. K. Jaakkola
Journal: Allergy (2001)

Background: It is still unclear how early‐life exposure to pets is related to children's risk of developing atopy‐related diseases. We estimated associations between early‐life exposure to pets and atopy‐related diseases at 0‐4 years of life in a cohort of Norwegian children. Methods: A population‐based cohort of 2531 children born in Oslo, Norway, was followed from birth to the age of 4 years. Information on early‐life exposure to pets, a number of possible confounders, and atopy‐related diseases was mainly collected by questionnaire. Results: In logistic regression analysis adjusting for potential confounders, the odds ratio for being exposed to pets in early life (reference category: not exposed) was, for bronchial obstruction at 0–2 years of life, 1.2 (95% confidence interval 0.9, 1.8); for asthma at the age of 4 years, 0.7 (0.5, 1.1); for allergic rhinitis at the age of 4 years, 0.6 (0.4, 1.0); and for atopic eczema at 0–6 months of life, 0.7 (0.5, 0.9). Conclusions: The results indicate that early‐life exposure to pets or lifestyle factors associated with exposure to pets reduce the risk of developing atopy‐related diseases in early childhood. However, these findings might also be explained by selection for keeping pets.
Decision Analysis in the Evaluation of Revascularization
Authors: Rolf M. Gunnar
Journal: Annals of Internal Medicine (1990)

ExcerptIn this issue, Dr. Wong and colleagues (1) evaluate the effects of revascularization for chronic stable angina, using a mathematical model to simulate clinical strategies. The model, however, is only as good as the database. A great deal of uncontrolled data on the outcome of patients treated with percutaneous transluminal coronary angioplasty (PTCA) and coronary artery bypass graft surgery (CABG) are available. Reliable information about the natural history of angina pectoris without mechanical intervention, however, is difficult to find.Wong and colleagues (1) rely quite heavily on data from the Coronary Artery Surgery Study (CASS) (2) as well as on...
The Age Factor in Hypercholesteremia and Atheromatosis in the Chick
Authors: S. RODBARD, L. N. KATZ, C. BOLENE, R. PICK, M. LOWENTHAL, G. GROS
Journal: Circulation (1951)

The development of atherosclerosis in very young chicks challenges the concept that atherogenesis depends upon senescence. Instead, the age period, rather than age, seems to be the more significant factor in atherogenesis. This is so since the regulation of the plasma cholesterol level is shown to vary at different age periods. During the first two months of life of the chick, a resistance to hypercholesteremia and atheromatosis is seen. At the eighth week, corresponding to the time of puberty, the plasma cholesterol rises markedly, despite an unchanged dietary regimen. The resistance to vascular lesions disappears and atheromatosis develops rapidly over the next few weeks. This indicates that endogenous mechanisms dependent upon the age period are important factors in the tendency to hypercholesteremia and atherogenesis.
KRAS and Guanine Nucleotide-Binding Protein Mutations in Pancreatic Juice Collected From the Duodenum of Patients at High Risk for Neoplasia Undergoing Endoscopic Ultrasound
Authors: James R Eshleman, Alexis L Norris, Yoshihiko Sadakari, Marija Debeljak, Michael Borges, Colleen Harrington, Elaine Lin, Aaron Brant, Thomas Barkley, J Alejandro Almario, Mark Topazian, James Farrell, Sapna Syngal, Jeffrey H Lee, Jun Yu, Ralph H Hruban, Mitsuro Kanda, Marcia Irene Canto, Michael Goggins
Journal: Clinical Gastroenterology and Hepatology (2014)
Plasma Micronutrients and the Acquisition and Clearance of Anal Human Papillomavirus Infection: The Hawaii HPV Cohort Study
Authors: Yurii B. Shvetsov, Brenda Y. Hernandez, Lynne R. Wilkens, Pamela J. Thompson, Adrian A. Franke, Xuemei Zhu, Marc T. Goodman
Journal: Cancer Research (2010)

Anal human papillomavirus (HPV) infection is common among women and the cause of most anal malignancies. The incidence of anal cancer has been increasing among U.S. women, yet few cofactors for the natural history of anal HPV infection have been identified. We examined the hypothesis that plasma carotenoid, retinol, and tocopherol concentrations are associated with the acquisition and clearance of anal HPV infection in a cohort of 279 Hawaiian residents followed at 4-month intervals for a mean duration of 16 months. At each visit, interviews were conducted and biological specimens were obtained, including anal cell specimens for HPV DNA detection and genotyping, and a fasting blood sample to measure 27 micronutrients. Cohort participants acquired 189 anal HPV infections, 113 of which cleared during the study period. The most frequently acquired HPV genotypes were HPV-52, -53, -84, and -16. Women in the highest quartile of trans-zeaxanthin, trans -anhydro-lutein, and trans-, cis-, and total β-carotene had significant 43% to 50% reduction in the risk of acquisition of any HPV infection compared with women in the lowest quartile. Few associations were observed between micronutrient levels and clearance of transient (≤ 150 days) anal HPV infections. However, clearance of persistent (> 150 days) infections was associated with higher levels of β-tocopherol + γ-tocopherol and lower levels of carotenoids and retinol. Our findings suggest that several carotenoids can reduce the risk and clearance of anal HPV infections that contribute to anal cancer.
A NEW TEST FOR SYPHILIS (THE EMULSOID-GELATION, OR THE “GEL” TEST)
Authors: J. E. R. McDONAGH
Journal: British Journal of Dermatology (1916)

Journal Article A NEW TEST FOR SYPHILIS (THE EMULSOID‐GELATION, OR THE “GEL” TEST) Get access J. E. R. McDONAGH, F.R.C.S J. E. R. McDONAGH, F.R.C.S Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 28, Issue 4-6, 6 April 1916, Pages 114–119, https://doi.org/10.1111/j.1365-2133.1916.tb16767.x Published: 06 April 1916