tbuckley/cabot-search huggingface dataset:
1157-43 Coronary flow velocity pattern immediately after percutaneous coronary intervention as a predictor of complications after acute myocardial infarction in patients achieving thrombolysis in myocardial infarction grade 3 flow
Authors: Atsushi Yamamuro, Takashi Akasaka, Koichi Tamita, Minako Katayama, Shuichiro Kaji, Kunihiko Nagai, Tomoko Tani, Kazuaki Tanabe, Shigefumi Morioka
Journal: Journal of the American College of Cardiology (2004)
Failure to achieve a complete hematologic response at the time of a major cytogenetic response with second-generation tyrosine kinase inhibitors is associated with a poor prognosis among patients with chronic myeloid leukemia in accelerated or blast phase
Authors: Carmen Fava, Hagop M. Kantarjian, Elias Jabbour, Susan O'Brien, Nitin Jain, Mary Beth Rios, Guillermo Garcia-Manero, Farhad Ravandi, Srdan Verstovsek, Gautam Borthakur, Jianqin Shan, Jorge Cortes
Journal: Blood (2009)
Geographic Variation in Cardiovascular Procedure Use Among Medicare Fee-for-Service vs Medicare Advantage Beneficiaries
Authors: Daniel D. Matlock, Peter W. Groeneveld, Steve Sidney, Susan Shetterly, Glenn Goodrich, Karen Glenn, Stan Xu, Lin Yang, Steven A. Farmer, Kristi Reynolds, Andrea E. Cassidy-Bushrow, Tracy Lieu, Denise M. Boudreau, Robert T. Greenlee, Jeffrey Tom, Suma Vupputuri, Kenneth F. Adams, David H. Smith, Margaret J. Gunter, Alan S. Go, David J. Magid
Journal: JAMA (2013)

Little is known about how different financial incentives between Medicare Advantage and Medicare fee-for-service (FFS) reimbursement structures influence use of cardiovascular procedures.To compare regional cardiovascular procedure rates between Medicare Advantage and Medicare FFS beneficiaries.Cross-sectional study of Medicare beneficiaries older than 65 years between 2003-2007 comparing rates of coronary angiography, percutaneous coronary intervention (PCI), and coronary artery bypass graft (CABG) surgery across 32 hospital referral regions in 12 states.Rates of coronary angiography, PCI, and CABG surgery.We evaluated a total of 878,339 Medicare Advantage patients and 5,013,650 Medicare FFS patients. Compared with Medicare FFS patients, Medicare Advantage patients had lower age-, sex-, race-, and income-adjusted procedure rates per 1000 person-years for angiography (16.5 [95% CI, 14.8-18.2] vs 25.9 [95% CI, 24.0-27.9]; P < .001) and PCI (6.8 [95% CI, 6.0-7.6] vs 9.8 [95% CI, 9.0-10.6]; P < .001) but similar rates for CABG surgery (3.1 [95% CI, 2.8-3.5] vs 3.4 [95% CI, 3.1-3.7]; P = .33). There were no significant differences between Medicare Advantage and Medicare FFS patients in the rates per 1000 person-years of urgent angiography (3.9 [95% CI, 3.6-4.2] vs 4.3 [95% CI, 4.0-4.6]; P = .24) or PCI (2.4 [95% CI, 2.2-2.7] vs 2.7 [95% CI, 2.5-2.9]; P = .16). Procedure rates varied widely across hospital referral regions among Medicare Advantage and Medicare FFS patients. For angiography, the rates per 1000 person-years ranged from 9.8 to 40.6 for Medicare Advantage beneficiaries and from 15.7 to 44.3 for Medicare FFS beneficiaries. For PCI, the rates ranged from 3.5 to 16.8 for Medicare Advantage and from 4.7 to 16.1 for Medicare FFS. The rates for CABG surgery ranged from 1.5 to 6.1 for Medicare Advantage and from 2.5 to 6.0 for Medicare FFS. Across regions, we found no statistically significant correlation between Medicare Advantage and Medicare FFS beneficiary utilization for angiography (Spearman r = 0.19, P = .29) and modest correlations for PCI (Spearman r = 0.33, P = .06) and CABG surgery (Spearman r = 0.35, P = .05). Among Medicare Advantage beneficiaries, adjustment for additional cardiac risk factors had little influence on procedure rates.Although Medicare beneficiaries enrolled in capitated Medicare Advantage programs had lower angiography and PCI procedure rates than those enrolled in Medicare FFS, the degree of geographic variation in procedure rates was substantial among Medicare Advantage beneficiaries and was similar in magnitude to that observed among Medicare FFS beneficiaries.
Contamination of Operating Room by Semi-closed Anesthesia System
Authors: Frank Cole
Journal: JAMA (1967)

To the Editor:—  Where surgeon and anesthetist once entered the operating room without modifying their persons or garb, they now don scrub suit, cap, and boots; the surgeon scrubs his hands and wears sterile gloves and gown, and everyone wears a mask. But the patient does not. With drop ether, it may be reasoned that the patient's face is covered and that the ether provides a sterile barrier. But with the use of the semi-closed method of administering anesthesia, which is employed with nitrous oxide and with halothane, the patient's exhalations escape into the room throughout the operation, and the result is as though the patient did not wear a mask. For the semi-closed method is not closed at all; it is quite open. In addition, whatever contaminants were introduced into the anesthesia machine by other patients are now freely distributed into the operating room atmosphere. It is therefore suggested
Inflammatory activity modulation by hypertonic saline and pentoxifylline in a rat model of strangulated closed loop small bowel obstruction
Authors: Roberto Rasslan, Edivaldo Massazo Utiyama, Geraldo Magela Nogueira Marques, Thiago Camargo Ferreira, Vitor Alves Pessoa da Costa, Nathalia Cruz de Victo, Samir Rasslan, Edna Frassonde Souza Montero
Journal: International Journal of Surgery (2014)
Time to Take Myocardial Reperfusion Injury Seriously
Authors: Derek J. Hausenloy, Derek M. Yellon
Journal: New England Journal of Medicine (2008)

Every year, 500,000 people in the United States have an ST-elevation myocardial infarction.1 Timely and effective reperfusion with the use of either primary percutaneous coronary intervention (PCI) or thrombolytic therapy remains the most effective treatment strategy for limiting the size of the myocardial infarct, preserving left ventricular ejection fraction, and improving the clinical outcomes in such patients. However, despite optimal reperfusion therapy, morbidity and mortality remain substantial, with about 5 to 6% of patients having a subsequent cardiovascular event by 30 days.2 One treatment strategy that might reduce the size of the infarct and improve the clinical outcomes in these . . .
The Centenary of the General Medical Council
Authors: F. N. L. Poynter
Journal: BMJ (1958)

The Medical Act of 1858 established as the chief agent of long overdue reform the General Council of Medical Education and Registration of the United Kingdom, referred to from its earliest days as the General Medical Council, a title officially adopted in 1951.The cen- tenary of the Council's first session falls on November 23, a date which should be memorable in the annals of British medicine as marking the first practical step towards the united and well-organized profession of to-day.
Immediate versus Delayed IUD Insertion after Uterine Aspiration
Authors: Paula H. Bednarek, Mitchell D. Creinin, Matthew F. Reeves, Carrie Cwiak, Eve Espey, Jeffrey T. Jensen
Journal: New England Journal of Medicine (2011)

Intrauterine devices (IUDs) provide highly effective, reversible, long-term contraception that is appropriate for many women after first-trimester uterine aspiration. However, the effects of immediate versus delayed IUD insertion after uterine aspiration on rates of complications and IUD use are uncertain.We performed a randomized noninferiority trial involving women undergoing uterine aspiration for induced or spontaneous abortion at 5 to 12 weeks of gestation who desired an IUD. Subjects were randomly assigned (in a 5:6 ratio) to IUD insertion immediately after the procedure or 2 to 6 weeks afterward (delayed insertion). The primary outcome was the rate of IUD expulsion 6 months after IUD insertion; an expulsion rate 8 percentage points higher in the immediate-insertion group was defined as inferior.Among 575 women who underwent randomization, an IUD was inserted in 100% (258 of 258) of the women in the immediate-insertion group and in 71.3% (226 of 317) of those in the delayed-insertion group (difference, 28.7 percentage points; 95% confidence interval [CI], 23.7 to 33.7). The 6-month expulsion risk was 5.0% (13 of 258 women) after immediate insertion and 2.7% (6 of 226) after delayed insertion (difference, 2.3 percentage points; 95% CI, -1.0 to 5.8), which was consistent with the predefined criterion for noninferiority. Six-month rates of IUD use were higher in the immediate-insertion group (92.3%, vs. 76.6% after delayed insertion; P<0.001). Adverse events were rare and did not differ significantly between groups. No pregnancies occurred in the immediate-insertion group; five occurred in the delayed-insertion group (P=0.07), all in women who never received an IUD.The 6-month rate of expulsion of an IUD after immediate insertion was higher than but not inferior to that after delayed insertion. Immediate insertion resulted in higher rates of IUD use at 6 months, without an increased risk of complications. (Funded by the Susan Thompson Buffett Foundation; ClinicalTrials.gov number, NCT00562276.).
Elevated Soft Tissue Activity in Early but not Delayed Phase of Bone Scan in Klippel-Trenaunay Syndrome
Authors: Bin Liu, Sabah Servaes, Hongming Zhuang
Journal: Clinical Nuclear Medicine (2013)

Triple-phase bone scan is commonly used in the diagnosis of osteomyelitis. Elevated bone tracer activity in early but not delayed phase of the study favors cellulitis over osteomyelitis. We reported that Klippel-Trenaunay syndrome, a congenital disorder characterized by malformations of the capillary, venous, and lymphatic systems, can have images similar to cellulitis on triple-phase bone scan.
RELATION OF PARTICLE SIZE OF C POLYSACCHARIDE COMPLEXES OF GROUP A STREPTOCOCCI TO TOXIC EFFECTS ON CONNECTIVE TISSUE
Authors: Bob S. Roberson, John H. Schwab, William J. Cromartie
Journal: The Journal of Experimental Medicine (1960)

The component of Group A streptococci which is responsible for the chronic, remittent, multinodular lesion of connective tissue is derived from the cell wall. Further evidence is given to support the essential role of the group-specific C polysaccharide in the production of this lesion. A series of particles containing the group-specific C polysaccharide was prepared, ranging in size from large cell wall fragments to the relatively small hapten. A comparison of the lesion producing capacity of the particles in this spectrum revealed that maximum toxic activity is associated with C polysaccharide complexes of intermediate size. The discussion considers colloidal properties associated with C polysaccharide complexes of a certain size, and the influence particle size has on persistence in tissue, as possible explanations of the relationship between the size of the C polysaccharide complex and its ability to produce the chronic lesion of connective tissue.
Abstract 2636: Nonmelanoma skin cancer as a marker of a cancer-prone phenotype: Potential role of DNA repair gene variants
Authors: Ingo Ruczinski, Timothy Jorgensen, Yin Yao Shugart, Yvette Berthier-Schaad, Bailey Kessing, Judithh Hoffman-Bolton, Kathy Helzlsouer, W.H. Linda Kao, Lee Wheless, Lesley Francis, Rhoda Alani, Paul Strickland, Michael Smith, Anthony J. Alberg
Journal: Cancer Research (2012)

Abstract Purpose: For unknown reasons, nonmelanoma skin cancer (NMSC) is associated with increased risk of other malignancies. This study tested the hypothesis that DNA repair gene variants contribute to the increased cancer risk associated with a personal history of NMSC. Methods: From the parent CLUE II cohort study, established in 1989 in Washington County MD, the study consisted of a cancer-free control group (n=2,296) compared to three mutually exclusive groups of cancer cases ascertained through 2007: 1) Other (non-NMSC) cancer only (n=2,349); 2) NMSC only (n=694); and 3) NMSC plus other cancer (n=577). The frequency of minor alleles in 759 DNA repair single nucleotide polymorphisms (SNPs) was compared in these four groups. Results: Comparing those with both NMSC and other cancer versus those with no cancer, 10 SNPs had additive model p-values&amp;lt;0.01. The two top-ranked SNPs were both within the thymine DNA glycosylase gene (TDG). One was a nonsynonymous coding SNP (rs2888805) (per allele odds ratio (OR) 1.40, 95% confidence interval (CI) 1.16-1.70; p-value=0.0006) and the other was an intronic SNP in high linkage disequilibrium with rs2888805 (rs4135150). Conclusion: The results pinpoint DNA repair genes most likely to contribute to the NMSC cancer-prone phenotype. A promising lead is genetic variants in TDG, important not only in base excision repair but also in regulating the epigenome and gene expression, which may contribute to the NMSC-associated increase in overall cancer risk. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2636. doi:1538-7445.AM2012-2636
INTERPLAY OF LIPID DROPLETS AND AUTOPHAGY REGULATES GLIOBLASTOMA SURVIVAL
Authors: D. Guo, F. Geng, R. Aggarwal, J. Liu, J. Y. Yoo, Q. Guo, J. Y. Guo, B. Hurwitz, P. Ru, C. Cheng, K. Joshi, N. Ichiro, B. Kaur, A. Chakravarti
Journal: Neuro-Oncology (2014)

BACKGROUND: (blind field). METHODS: Live cell and time-lapse imaging, electronic and fluorescence microscopy, lipid analytic assay, nuclear magnetic resonance, western blotting, cell proliferation and cell death assay are performed to investigate lipid droplets (LDs) function in GBM. RESULTS: By analysis of brain tissues from GBM patients and xenografts via electronic microscopy and fluorescence imaging, our data firstly show that lipid droplets (LDs), special organelles to store excessive cholesteryl esters (CE) and triglycerides (TG), are largely enriched in tumor tissues but not detectable in normal brain tissues. Intriguingly, the role of LDs and how they are metabolized in cancer cells are completely unknown. We then show that GBM cells containing higher LD numbers are less sensitive to the treatments aiming to reduce cellular cholesterol levels. Furthermore, we find that removing cholesterol from cellular media, increasing cholesterol efflux by activation of liver X receptor (LXR), or depleting cholesterol from plasma membranes via β-methyl-cyclodextrin (β-MCD) treatment, strongly triggers autophagy to hydrolyze LDs and releases free cholesterol. This LD-derived cholesterol is shown to translocate to plasma membranes and maintain cellular cholesterol homeostasis. More interestingly, blocking autophagy leads to large amounts of LD accumulation and results in dramatic GBM cell death upon these treatments. CONCLUSIONS: Our data are the first to identify that LDs are the unique organelles enriched in GBM patient tumor tissues. Furthermore, we reveal a previously unrecognized pro-survival feedback and feed-forward metabolic reprogramming pathway through a LD-autophagy-cholesterol re-distribution process that maintains cholesterol homeostasis and GBM growth and survival. Our data suggest a novel therapeutic strategy to treat GBM by interrupting LD metabolism. SECONDARY CATEGORY: Neuropathology & Tumor Biomarkers.
Simultaneous occurrence of tetrasomy 21 and trisomy 8 in a patient with early blastic metamorphosis of chronic myeloproliferative disorder
Authors: Lucia Sebastio, Felicetto Ferrara, Laura Vicari, Rosella Di Noto, Luigi Del Vecchio, Fabrizio Pane, Alfredo Fasanaro, Renato Cimino, Francesco Salvatore, Valerio Ventruto
Journal: American Journal of Hematology (1995)

We report an unusual hyperdiploid karyotype characterized by the simultaneous occurrence of tetrasomy 21 and trisomy 8 detected during early blastic evolution of a BCR-ABL-negative chronic myeloproliferative disorder. Blast cells from this patient showed a striking response to all-trans-retinoic acid (ATRA)-induced differentiation as evaluated by CD15 expression following in vitro exposure to this inducer. Our report represents the first description of such a composite karyotype in human hematologic malignancies.
Pursuit of Health
Authors: Samuel Vaisrub
Journal: JAMA (1976)

Are we unduly concerned with health? If the Declaration of Independence were written today would "the pursuit of health" rather than "the pursuit of happiness" be our third inalienable right? A few decades ago such questions would not have arisen. If anything, public apathy rather than concern worried yesterday's physician, who was apt to be frustrated by a patient's disregard of symptoms, delay in seeking medical advice, tendency to "fight off" disease, and lackadaisical attitude toward disease and its prevention. Just how radically this attitude has changed is brought to our attention by two recent comments—one by Lewis Thomas<sup>1</sup>in a chapter on health care in his<i>Notes of a Biology Watcher</i>, and the other by Alan Klass<sup>2</sup>in his recently published book,<i>There's Gold in Them Thar Pills</i>. Painting on a wide canvas, Thomas depicts not only the gigantic, multimillion-dollar "authorized" collective effort of hospital charges, prescribed
RAD001 (Everolimus) Delays Tumor Onset and Progression in a Transgenic Mouse Model of Ovarian Cancer
Authors: Seiji Mabuchi, Deborah A. Altomare, Denise C. Connolly, Andres Klein-Szanto, Samuel Litwin, Matthew K. Hoelzle, Harvey H. Hensley, Thomas C. Hamilton, Joseph R. Testa
Journal: Cancer Research (2007)

Abstract The mammalian target of rapamycin (mTOR) is thought to play a critical role in regulating cell growth, cell cycle progression, and tumorigenesis. Because the AKT-mTOR pathway is frequently hyperactivated in ovarian cancer, we hypothesized that the mTOR inhibitor RAD001 (Everolimus) would inhibit ovarian tumorigenesis in transgenic mice that spontaneously develop ovarian carcinomas. We used TgMISIIR-TAg transgenic mice, which develop bilateral ovarian serous adenocarcinomas accompanied by ascites and peritoneal dissemination. Fifty-eight female TgMISIIR-TAg mice were treated with 5 mg/kg RAD001 or placebo twice weekly from 5 to 20 weeks of age. To monitor tumor development, mice were examined biweekly using magnetic resonance microimaging. In vivo effects of RAD001 on Akt-mTOR signaling, tumor cell proliferation, and blood vessel area were analyzed by immunohistochemistry and Western blot analysis. RAD001 treatment markedly delayed tumor development. Tumor burden was reduced by ∼84%. In addition, ascites formation, together with peritoneal dissemination, was detected in only 21% of RAD001-treated mice compared with 74% in placebo-treated animals. Approximately 30% of RAD001-treated mice developed early ovarian carcinoma confined within the ovary, whereas all placebo-treated mice developed advanced ovarian carcinoma. Treatment with RAD001 diminished the expression of vascular endothelial growth factor in tumor-derived cell lines and inhibited angiogenesis in vivo. RAD001 also attenuated the expression of matrix metalloproteinase-2 and inhibited the invasiveness of tumor-derived cells. Taken together, these preclinical findings suggest that mTOR inhibition, alone or in combination with other molecularly targeted drugs, could represent a promising chemopreventive strategy in women at high familial risk of ovarian cancer. [Cancer Res 2007;67(6):2408–13]
Glycerol production in subcutaneous adipose tissue in lean and obese humans.
Authors: P A Jansson, A Larsson, U Smith, P Lönnroth
Journal: Journal of Clinical Investigation (1992)

To estimate the regional subcutaneous glycerol production rate in normal and obese humans, the venous arterialized plasma glycerol, interstitial glycerol in the subcutaneous adipose tissue together with adipose tissue blood flow (ATBF, ml/100 g.min) were measured in the postabsorptive state and for 2 h after ingestion of 100 g of oral glucose. Eight lean and eight obese men with normal oral glucose tolerance tests were investigated with the subcutaneous microdialysis technique and 133Xe clearance. In the postabsorptive state, the interstitial glycerol concentrations in lean and obese subjects were 170 +/- 21 vs. 282 +/- 28 microM (P less than 0.01) and 156 +/- 23 vs. 225 +/- 12 microM (P less than 0.05) in the abdominal and femoral subcutaneous adipose tissue, respectively. The corresponding arterial glycerol levels were 54 +/- 4 vs. 75 +/- 14 microM (NS). Abdominal ATBF was greater in lean subjects (3.2 +/- 0.6 vs. 1.6 +/- 0.3; P less than 0.05), whereas femoral ATBF was similar in both groups (2.7 +/- 0.4 vs. 2.4 +/- 0.7). Estimated mean local glycerol release (mumol/100 g.min) was similar in the lean and obese group (0.16 +/- 0.03 vs. 0.20 +/- 0.05 and 0.18 +/- 0.02 vs. 0.17 +/- 0.04) in the abdominal and femoral site, respectively. We conclude that glycerol production from the subcutaneous tissue is increased in obesity, irrespective of adipose tissue distribution. This enhancement is due to the increased adipose tissue mass.
Elevated Atypical Creatine Kinases-Reply
Authors: Gary R. Gibson
Journal: JAMA (1986)

<h3>In Reply.—</h3> We appreciate the letter from Chastain and his colleagues regarding atypical creatine kinases. It is a valuable expansion of the discussion offered in our CASE REPORT. Review of the literature by us and by Chastain et al has revealed many instances of CK-MM and CK-BB complexed to other substances. We hope their experimental observations will help to refine the assay for the CK-MB isoenzyme. The electrophoretic assay for the CK-MB isoenzyme remains the most sensitive and specific test for diagnosing myocardial infarction, but awareness of its decreased specificity in patients with cancer will enhance its application. The letter by Drs Lee and Horton is of special significance because they demonstrate "CK-MB" in the actual tumor tissue. We could only presume that the atypical CK was produced by the tumor, since our patient did not undergo an autopsy. Their patient had small-cell carcinoma of the lung; ectopic production of
A review of minimally invasive cosmetic procedures
Authors: S. Ogden, T.W. Griffiths
Journal: British Journal of Dermatology (2008)

Journal Article A review of minimally invasive cosmetic procedures Get access S. Ogden, S. Ogden Dermatological Sciences, University of Manchester, Manchester, U.K. Correspondence: Stephanie Ogden. E‐mail: stephanie.ogden@hotmail.co.uk Search for other works by this author on: Oxford Academic Google Scholar T.W. Griffiths T.W. Griffiths Dermatological Sciences, University of Manchester, Manchester, U.K.Dermatology Department, Macclesfield District General Hospital, Macclesfield, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 159, Issue 5, 1 November 2008, Pages 1036–1050, https://doi.org/10.1111/j.1365-2133.2008.08845.x Published: 01 November 2008
Peripheral blood lymphocytes genetically modified to express the self/tumor antigen MAGE-A3 induce antitumor immune responses in cancer patients
Authors: Raffaella Fontana, Marco Bregni, Arcadi Cipponi, Laura Raccosta, Cristina Rainelli, Daniela Maggioni, Francesca Lunghi, Fabio Ciceri, Sylvain Mukenge, Claudio Doglioni, Didier Colau, Pierre G. Coulie, Claudio Bordignon, Catia Traversari, Vincenzo Russo
Journal: Blood (2008)
EVALUATION OF LEFT VENTRICULAR FILLING PRESSURES USING TISSUE DOPPLER DERIVED MYOCARDIAL ACCELERATION DURING ISOVOLUMIC CONTRACTION
Authors: Alaa Omar, Hidekazu Tanaka, Kensuke Matsumoto, Yoshiki Motoji, Junichi Imanishi, Tatsuya Myoshi, Mana Hiraishi, Takayuki Tsuji, Akihiro Kaneko, Keiko Ryo, Yuko Fukuda, Kazuhiro Tatsumi, Hiroya Kawai, Ken-ichi Hirata
Journal: Journal of the American College of Cardiology (2012)