Control of Heme Oxygenase and Plasma Levels of Bilirubin by a Synthetic Heme Analogue, Tin-Protoporphyrin
Authors: Attallah Kappas, George S. Drummond, Creuza S. Simionatto, Karl E. Anderson
Journal: Hepatology (1984)

HepatologyVolume 4, Issue 2 p. 336-341 Special ArticleFree Access Control of Heme Oxygenase and Plasma Levels of Bilirubin by a Synthetic Heme Analogue, Tin-Protoporphyrin Attallah Kappas, Corresponding Author Attallah Kappas The Rockefeller University Hospital, 1230 York Avenue, New York, New York 10021Attallah Kappas, M.D., The Rockefeller University Hospital, 1230 York Avenue, New York, New York 10021===Search for more papers by this authorGeorge S. Drummond, George S. Drummond The Rockefeller University Hospital, 1230 York Avenue, New York, New York 10021Search for more papers by this authorCreuza S. Simionatto, Creuza S. Simionatto The Rockefeller University Hospital, 1230 York Avenue, New York, New York 10021Search for more papers by this authorKarl E. Anderson, Karl E. Anderson The Rockefeller University Hospital, 1230 York Avenue, New York, New York 10021Search for more papers by this author Attallah Kappas, Corresponding Author Attallah Kappas The Rockefeller University Hospital, 1230 York Avenue, New York, New York 10021Attallah Kappas, M.D., The Rockefeller University Hospital, 1230 York Avenue, New York, New York 10021===Search for more papers by this authorGeorge S. Drummond, George S. Drummond The Rockefeller University Hospital, 1230 York Avenue, New York, New York 10021Search for more papers by this authorCreuza S. Simionatto, Creuza S. Simionatto The Rockefeller University Hospital, 1230 York Avenue, New York, New York 10021Search for more papers by this authorKarl E. Anderson, Karl E. Anderson The Rockefeller University Hospital, 1230 York Avenue, New York, New York 10021Search for more papers by this author First published: March‐April 1984 https://doi.org/10.1002/hep.1840040227Citations: 52AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 DeMatteis F. Loss of microsomal components in drug induced liver damage, in cholestasis and after chemicals which stimulate heme catabolism. In: JB Schenkman, D Kupfer, eds. Pharmacological Therapeutics A, Vol 2. Great Britain: Pergamon Press Ltd., 1978: 693–725. 2 Conney AH. Pharmacological implications of microsomal enzyme induction. Pharmac Rev 1967; 19: 317–366. 3 Kappas A, Sassa S, Anderson KE. The porphyrias. In: JB Stanbury, JB Wyngaarden, DS Fredrickson, et al., eds. The metabolic basis of inherited diseases 5th ed New York: McGraw Hill Book Company, 1983: 1301–1384. 4 Tenhunen R, Marver HS, Schmid R. The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase. Proc Natl Acad Sci USA 1968; 61: 748–755. 5 Maines MD, Kappas A. Cobalt induction of hepatic heme oxygenase; with evidence that cytochrome P-450 is not essential for this enzyme activity. Proc Natl Acad Sci USA 1974; 71: 4293–4297. 6 Drummond GS, Kappas A. Prevention of neonatal hyperbilirubinemia by tin-protoporphyrin IX, a potent competitive inhibitor of heme oxidation. Proc Natl Acad Sci USA 1981; 78: 6466–6470. 7 Song CS, Moses HL, Rosenthal AS, et al. The influence of postnatal development on drug induced hepatic porphyria and the synthesis of cytochrome P-450: a biochemical and morphological study. J Exp Med 1971; 134: 1349–1371. 8 Drummond GS, Kappas A. Metal ion interactions in the control of haem oxygenase induction in liver and kidney. Biochem J 1980; 192: 637–648. 9 Sardana MK, Sassa S, Kappas A. Metal ion-mediated regulation of heme oxygenase induction in cultured avian liver cells. J Biol Chem 1982; 257: 4806–4811. 10 Sunderman FW Jr, Lau TJ, Cralley LJ. Inhibitory effect of manganese upon muscle tumorigenesis by nickel subsulfide. Cancer Res 1974; 34: 92–95. 11 Maines MD, Kappas A. Enzymatic oxidation of cobalt protoporphyrin IX. Observations on the mechanism of heme oxygenase action. Biochemistry 1977; 16: 419–423. 12 Yoshinaga T, Sassa S, Kappas A. Purification and properties of bovine spleen heme oxygenase; amino acid composition and sites of action of inhibitors of heme oxidation. J Biol Chem 1982; 257: 7778–7785. 13 Yoshinaga T, Sassa S, Kappas A. The occurrence of molecular interactions among NADPH-cytochrome c reductase, heme oxygenase, and biliverdin reductase in heme degradation. J Biol Chem 1982; 257: 7786–7793. 14 Drummond GS, Kappas A. The cytochrome P-450 depleted animal: an experimental model for in vivo studies in chemical biology. Proc Natl Acad Sci USA 1982; 79: 2384–2388. 15 Sassa S, Drummond GS, Bernstein SE, et al. Tin-protoporphyrin suppression of hyperbilirubinemia in mutant mice with severe hemolytic anemia. Blood 1983; 61: 1011–1013. 16 Schacter BA, Joseph E, Firneiz G. Effect of cholestasis produced by bile duct ligation on hepatic heme and hemoprotein metabolism in rats. Gastroenterology 1983; 84: 227–235. 17 Hammaker L, Schmid R. Interference with bile pigment intake in the liver by flavaspidic acid. Gastroenterology 1967; 53: 31–37. 18 Cornelius C, Rodgers PA. Prevention of neonatal hyperbilirubinemia in rhesus monkeys by tin-protoporphyrin. Pediatrics 1984 (in press). 19 Anderson KE, Simionatto CS, Drummond GS, et al. Tissue distribution and disposition of tin-protoporphyrin, a potent competitive inhibitor of heme oxygenase. J Pharm Exp Ther 1984; 228: 327–333. 20 Drummond GS, Kappas A. Suppression of hyperbilirubinemia in the rat neonate by chromium protoporphyrin. J Exp Med 1982; 156: 1878–1883. 21 Maines MD. Zin-protoporphyrin is a selective inhibitor of heme oxygenase activity in the neonatal rat. Biochim Biophys Acta 1981; 673: 339–350. 22 Drummond GS, Kappas A. Chemoprevention of neonatal jaundice: potency of tin-protoporphyrin in an animal model. Science 1982; 217: 1250–1252. 23 Maines MD, Veltman JC. Phenylhydrazine-mediated induction of haem oxygenase activity in rat liver and kidney and development of hyperbilirubinemia: inhibition by zinc-protoporphyrin. Biochem J 1984; 217: 409–417. 24 Bloomer JR, Reuter RJ, Morton KO, et al. Enzymatic formation of zinc-protoporphyrin by rat liver and its potential effect on hepatic heme metabolism. Gastroenterology 1983; 85: 663–668. 25 Drummond GS, Rosenberg DW, Kappas A. Metal induction of haem oxygenase without concurrent degradation of cytochrome P-450: protective effects of SKF 525A on the haem protein. Biochem J 1982; 202: 59–66. 26 Kutty RK, Maines MD. Purification and characterization of biliverdin reductase from rat liver. J Biol Chem 1981; 256: 3956–3962. 27 Bissell DM, Gunzelian PS. Degradation of endogenous hepatic heme by pathways not yielding carbon monoxide. Studies in normal rat liver and in primary hepatocyte culture. J Clin Invest 1980; 65: 1135–1140. 28 Kapitulnik J, Ostrow JD. Stimulation of bilirubin catabolism in jaundiced Gunn rats by an inducer of microsomal mixed-function monooxygenases. Proc Natl Acad Sci USA 1977; 75: 682–685. Citing Literature Volume4, Issue2March‐April 1984Pages 336-341 ReferencesRelatedInformation