tbuckley/cabot-search huggingface dataset:
Sequencing of type I IGF receptor (IGF1R) inhibition affects chemotherapy response in vitro and in vivo.
Authors: X Zeng, D Sachdev, H Zhang, D Yee
Journal: Cancer Research (2009)

Abstract Abstract #3122 Purpose: To determine the optimal sequence of combining anti-IGF1R antibodies with chemotherapeutic drugs in cancer cells in vitro and in vivo.&amp;#x2028; Experimental design: MCF-7 and LCC6 cells were treated with sub-cytotoxic concentrations of doxorubicin (DOX) with or without anti-IGF1R antibodies (scFv-Fc or EM164 and its humanized version AVE1642). Treatments were given simultaneously, DOX followed by anti-IGF1R antibody, or anti-IGF1R antibody followed by DOX, with measurement of in vitro proliferation, apoptosis, and anchorage-independent growth. Effects of sequencing on LCC6 xenograft growth and metastasis were studied.&amp;#x2028; Results: DOX followed by anti-IGF1R antibody (scFv-Fc or EM164) was the most effective combination strategy to inhibit cell monolayer growth and anchorage-independent growth. This sequential combination triggered increased Poly (ADP-ribose) polymerase (PARP) cleavage compared to other treatment sequences. The reverse sequence, antibody followed by DOX treatment, protected cells from chemotherapy by decreasing apoptosis, arresting cells in S phase, and inhibiting the level and activity of topoisomerase IIα . Finally, our in vivo data show that recovery of IGF1R prior to DOX therapy resulted in the best therapeutic responses. Low doses of AVE1642 that allowed IGF1R expression to recover at one week were more effective in combination with DOX than higher antibody doses.&amp;#x2028; Conclusion: The timing of IGF1R inhibition affects responses to chemotherapy. The optimal sequence was DOX followed by anti-IGF1R antibody, while the opposite sequence inhibited DOX effects. Thus, short course suppression in combination with DOX might be the optimal combination and provides a rationale for the design of future clinical trials. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 3122.
Sex differences in the clinical presentation and management of airflow obstruction
Authors: R. E. Dales, A. Mehdizadeh, S. D. Aaron, K. L. Vandemheen, J. Clinch
Journal: European Respiratory Journal (2006)

The aim of the present study was to explore differences in the clinical expression, clinical diagnoses and management of airway diseases in a primary-care setting. Patients aged ≥35 yrs who had ever smoked were enrolled when they presented for any reason to one of eight rural primary-care practices. Respiratory symptom questionnaires and spirometry were administered. In total, 1,034 patients had acceptable and reproducible spirometry, of whom 550 (53%) were males and 484 (47%) were females. Males smoked more than females (41.2 versus 29.2 pack-yrs) respectively, and were more likely to have a pre-bronchodilator forced expiratory volume in one second/forced vital capacity &lt;0.70 at 22.4 versus 11.8%, respectively. However, more females than males reported breathlessness (51.0 versus 42.8%, respectively), a prior diagnosis compatible with airflow obstruction and taking respiratory medications (23.4 versus 14.9%, respectively). In conclusion, the current results suggest that females are more likely than males to report breathlessness and be prescribed respiratory medications independent of differences in the severity of airflow obstruction.
Circadian Rhythm of Transferrin Receptor 1 Gene Expression Controlled by c-Myc in Colon Cancer–Bearing Mice
Authors: Fumiyasu Okazaki, Naoya Matsunaga, Hiroyuki Okazaki, Naoki Utoguchi, Ryo Suzuki, Kazuo Maruyama, Satoru Koyanagi, Shigehiro Ohdo
Journal: Cancer Research (2010)

The abundance of cell surface levels of transferrin receptor 1 (TfR1), which regulates the uptake of iron-bound transferring, correlates with the rate of cell proliferation. Because TfR1 expression is higher in cancer cells than in normal cells, it offers a target for cancer therapy. In this study, we found that the expression of TfR1 in mouse colon cancer cells was affected by the circadian organization of the molecular clock. The core circadian oscillator is composed of an autoregulatory transcription-translation feedback loop, in which CLOCK and BMAL1 are positive regulators and the Period (Per), Cryptochrome (Cry), and Dec genes act as negative regulators. TfR1 in colon cancer-bearing mice exhibited a 24-hour rhythm in mRNA and protein levels. Luciferase reporter analysis and chromatin immunoprecipitation experiments suggested that the clock-controlled gene c-MYC rhythmically activated the transcription of the TfR1 gene. Platinum incorporation into tumor DNA and the antitumor efficacy of transferrin-conjugated liposome-delivered oxaliplatin could be enhanced by drug administration at times when TfR1 expression increased. Our findings suggest that the 24-hour rhythm of TfR1 expression may form an important aspect of strategies for TfR1-targeted cancer therapy.
Perivascular Superoxide Anion Contributes to Impairment of Endothelium-Dependent Relaxation
Authors: Federico E. Rey, Xiao-Chun Li, Oscar A. Carretero, Jeffrey L. Garvin, Patrick J. Pagano
Journal: Circulation (2002)

Like endothelial and smooth muscle cells, vascular adventitial fibroblasts contain a substantial NAD(P)H oxidase superoxide anion (O2-)-generating system activated by angiotensin II (Ang II). Based on the ability of nitric oxide (NO*) to diffuse rapidly through tissue and the fast reaction rate of NO* and O2-, we postulated that the interaction between NO. and adventitial NAD(P)H oxidase-derived O2- contributes to impairment of endothelium-dependent relaxation (EDR).C57Bl/6 mouse abdominal aortas were simultaneously perfused intraluminally and suffused adventitially with physiological buffer at 37 degrees C. After constricting the vessels with phenylephrine, an acetylcholine dose-response curve was obtained while monitoring changes in diameter by videomicroscopy. Endogenous O2- was increased by treating the adventitial side of the aortas with Ang II (10 pmol/L), leading to impairment of EDR. EDR impairment was reversed by adventitial suffusion of superoxide dismutase (SOD) of aortas from wild-type mice. Ang II-treated aortas from gp91(phox-/-) mice, which lack significant adventitial O2-, exhibited greater EDR and were not affected by SOD. Adventitially suffused SOD failed to penetrate the media, indicating that the effects of SOD were localized to the adventitia. Adventitial application of the O2--generating system xanthine/xanthine oxidase or the potent NO scavenger oxyhemoglobin impaired EDR.O2- derived from adventitial gp91(phox)-based NAD(P)H oxidase contributes to impairment of the action of endothelium-derived NO.
Synaptic PI(3,4,5)P3 Is Required for Syntaxin1A Clustering and Neurotransmitter Release
Authors: Thang Manh Khuong, Ron L.P. Habets, Sabine Kuenen, Agata Witkowska, Jaroslaw Kasprowicz, Jef Swerts, Reinhard Jahn, Geert van den Bogaart, Patrik Verstreken
Journal: Neuron (2013)
A role for mitogen-activated protein kinase activation by integrins in the pathogenesis of psoriasis
Authors: Ingo Haase, Robin M. Hobbs, M. Rosario Romero, Simon Broad, Fiona M. Watt
Journal: Journal of Clinical Investigation (2001)

In normal epidermis, β1 integrin expression is confined to the basal layer, whereas in hyperproliferative epidermis, integrins are also expressed in the suprabasal layers. Transgenic mice in which integrins are expressed suprabasally via the involucrin promoter have a sporadic psoriatic phenotype; however, the mechanism by which integrins contribute to the pathogenesis of psoriasis is unknown. We observed activation of mitogen-activated protein kinase (MAPK) in basal and suprabasal keratinocytes of human and transgenic mouse psoriatic lesions and healing mouse skin wounds, correlating in each case with suprabasal integrin expression. Phenotypically normal human and transgenic mouse epidermis did not contain activated MAPK. Transgene-positive keratinocytes produced more IL-1α than controls did, and keratinocyte MAPK could be activated by ligation of suprabasal integrins or treatment with IL-1α. Constitutive activation of MAPK increased the growth rate of human keratinocytes and delayed the onset of terminal differentiation, recreating many of the histological features of psoriatic epidermis. We propose that activation of MAPK by integrins, either directly or through increased IL-1α production, is responsible for epidermal hyperproliferation in psoriasis and wound healing, and that the sporadic phenotype of the transgenic mice may reflect the complex mechanisms by which IL-1 release and responsiveness are controlled in skin.
Long-Term Efficacy of Catheter Ablation of Ventricular Tachycardia in Patients With Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy
Authors: Darshan Dalal, Rahul Jain, Harikrishna Tandri, Jun Dong, Shaker M. Eid, Kalpana Prakasa, Crystal Tichnell, Cynthia James, Theodore Abraham, Stuart D. Russell, Sunil Sinha, Daniel P. Judge, David A. Bluemke, Joseph E. Marine, Hugh Calkins
Journal: Journal of the American College of Cardiology (2007)
Pancreatic Carcinoma: Applications for Helical Computed Tomography
Authors: L. Van Hoe, A. L. Baert
Journal: Endoscopy (1997)

Helical computed tomography (CT) represents a significant technical improvement over conventional (incremental) CT. This noninvasive imaging technique is now routinely used in the evaluation of patients with suspected pancreatic cancer. This paper focuses on the topics of CT technique (scanning parameters, use of intravenous contrast media, use of oral contrast media and spasmolytic agents, calculation of reformatted and projective images), as well as on the CT appearance of pancreatic carcinoma and the differential diagnosis and staging. A short comparison with other methods is included.
Mild ulcerative colitis.
Authors: A K Maitra
Journal: BMJ (1970)

atrium.A convenient external reference point for this in a supine patient is the mid axillary point.This level was presumably used by A. E. Baue, whose review we quoted.Some prefer to use the sternal angle as a reference level, in which case the recorded pressures will, of course, be lower.Since the usefulness of C.V.P. measurements is not in their absolute values but in changes of C.V.P. that take place it is of little importance which reference point is chosen, provided the same point is used consistently.-ED., B.
Ascorbic acid mitigates the myocardial injury after cardiac arrest and electrical shock
Authors: Min-Shan Tsai, Chien-Hua Huang, Chia-Ying Tsai, Huei-Wen Chen, Hsin-Chen Lee, Hsaio-Ju Cheng, Chiung-Yuan Hsu, Tzung-Dau Wang, Wei-Tien Chang, Wen-Jone Chen
Journal: Intensive Care Medicine (2011)
Fatal upper gastrointestinal bleeding caused by a metal biliary stent despite stent shortening with APC
Authors: S. Dokas, V. Kotsis, G. Milionis, G. Lazaraki, M. Sion
Journal: Endoscopy (2008)

A 75-year-old man presented with hematemesis and melena. He had received an uncovered nitinol self-expanding metal stent (SEMS) 2 months previously for inoperable obstructive hilar cholangiocarcinoma.
Empirical Hypotheses on the Psychotherapeutic Treatment of Psychosomatic Patients in Short and Long-Term Time-Unlimited Psychotherapy
Authors: Hans Kordy, Michael von Rad, Wolfgang Senf
Journal: Psychotherapy and Psychosomatics (1989)

In the Heidelberg Follow-Up Project, the results of psychoanalytically oriented treatment in a practice-oriented design are investigated. The patient sample is not homogeneous with regard to the diagnosis; the sample (n = 209) comprised primarily psychoneurotic and psychosomatic patients. All treatments were intended as long-term psychotherapies. The duration of therapy as well as the number of sessions actually realized may be regarded as one result of therapy. This situation, which is not quite ideal in the classical clinical experiment, allows us to develop the following empirical hypotheses: (1) The relationship between the therapeutic effort (e.g. treatment duration and number of sessions) and the results of psychotherapy can be mapped by a dose-effect model. The formal characteristics, especially the shape of the corresponding graphs, are similar for four different evaluation levels. Within the context of a dose-effect model, a treatment duration of about 2.5 years or respectively a number of sessions of about 160 seem to be most beneficial. (2) If we split up the total sample of patients into two subgroups (group 1: patients with psychoneurotic symptoms or non-chronified bodily dysfunctions; group 2: patients with psychosomatic illnesses or chronified bodily dysfunctions) and repeat the analysis, we obtain similar results for both groups of patients. The dose-effect graphs are of similar shape but differ in height. There is a slight tendency in patient group 2 that a treatment duration of up to 3.5 years may be associated with increased success rates.
Comprehensive Discharge Planning for the Hospitalized Elderly
Authors: Mary Naylor
Journal: Annals of Internal Medicine (1994)

Objective: To study the effects of a comprehensive discharge planning protocol, designed specifically for the elderly and implemented by nurse specialists, on patient and caregiver outcomes and cost of care. Design: Randomized clinical trial. Setting: Hospital of the University of Pennsylvania. Patients: 276 patients and 125 caregivers. Patients were 70 years and older and were placed in selected medical and surgical cardiac diagnostic-related groups. Measurements: Group differences in patient outcomes (length of initial hospital stay, length of time between initial hospital discharge and readmission, and rehospitalization rates) and charges for care (charges for initial hospitalization, rehospitalizations, health services after discharge, and nurse specialist services) were measured 2, 6, and 12 weeks after discharge. Results: From the initial hospital discharge to 6 weeks after discharge, patients in the medical intervention group had fewer readmissions, fewer total days rehospitalized, lower readmission charges, and lower charges for health care services after discharge. No differences in these outcomes were found between the surgical intervention and control groups during this period. Conclusions: Study findings support the need for comprehensive discharge planning designed for the elderly and implemented by nurse specialists to improve their outcomes after hospital discharge and to achieve cost savings. The findings also suggest that this intervention had its greatest effect in delaying or preventing rehospitalization of patients in the medical intervention group during the first 6 weeks after discharge.
Itm2a Is Induced during Thymocyte Selection and T Cell Activation and Causes Downregulation of Cd8 When Overexpressed in Cd4+Cd8+ Double Positive Thymocytes
Authors: Jacqueline Kirchner, Michael J. Bevan
Journal: The Journal of Experimental Medicine (1999)

To identify novel genes that are involved in positive selection of thymocytes, we performed polymerase chain reaction (PCR)-based subtractive hybridization between selecting and nonselecting thymi. OT-1 T cell receptor (TCR) transgenic thymocytes on a recombination activating gene (RAG) null background are efficiently selected into the CD8 lineage in H-2b mice (RAG-2−/−OT-1, selecting thymi), but are not selected on a transporter associated with antigen processing (TAP) null background (RAG-2−/−TAP-1−/−OT-1, nonselecting thymi). We report here our studies of one gene, ITM2A, whose expression is dramatically higher in T cells in the selecting thymus. The expression pattern of ITM2A in thymocyte subsets correlates with upregulation during positive selection. In addition, ITM2A expression is higher in the thymus than in either the spleen or lymph nodes, but can be upregulated in peripheral T cells upon activation. ITM2A expression was also induced in RAG-2−/− thymocytes in vivo upon CD3 cross-linking. We demonstrate that ITM2A is a type II membrane glycoprotein that exists as two species with apparent Mr of 45 and 43 kD and appears to localize primarily to large cytoplasmic vesicles and the Golgi apparatus, but is also expressed on the cell surface. Expression on the surface of EL4 cells increases with activation by phorbol myristate acetate (PMA) and ionomycin. Finally, overexpression of ITM2A under control of the lck proximal promoter in mice results in partial downregulation of CD8 in CD4+CD8+ double positive (DP) thymocytes, and a corresponding increase in the number of CD4+CD8lo thymocytes. Possible roles for this novel activation marker in thymocyte development are discussed.
ECHINOCOCCUS CYST OF THE KIDNEY
Authors: DAVID R. MELEN
Journal: JAMA (1925)

Echinococcus disease limited to a kidney is very rare in this country. Up to and including Kretschmer's 1 case in 1923, there have been eighteen cases reported. These have been reviewed and abstracted by him. In only two of these had pyelograms been done, once by Young, 2 who reported an abnormal pelvis, and once by Kretschmer, who showed a picture of an area of calcification depressing the calices. There is nothing characteristic in pyelography of this condition.  REPORT OF CASE  History.  —Mrs. B. N., aged 43, Italian housewife, was admitted to the hospital complaining of a large mass in the left side of the abdomen. The family history was not noteworthy. The patient had come to New York State eleven years before, from Italy, and had lived here since. She had always been strong and well and had never had any operations or previous illnesses. The present illness began
Exposure assessment of particulate matter for susceptible populations in Seattle.
Authors: L-J Sally Liu, Michael Box, David Kalman, Joel Kaufman, Jane Koenig, Tim Larson, Thomas Lumley, Lianne Sheppard, Lance Wallace
Journal: Environmental Health Perspectives (2003)

In this article we present results from a 2-year comprehensive exposure assessment study that examined the particulate matter (PM) exposures and health effects in 108 individuals with and without chronic obstructive pulmonary disease (COPD), coronary heart disease (CHD), and asthma. The average personal exposures to PM with aerodynamic diameters < 2.5 microm (PM2.5) were similar to the average outdoor PM2.5 concentrations but significantly higher than the average indoor concentrations. Personal PM2.5 exposures in our study groups were lower than those reported in other panel studies of susceptible populations. Indoor and outdoor PM2.5, PM10 (PM with aerodynamic diameters < 10 microm), and the ratio of PM2.5 to PM10 were significantly higher during the heating season. The increase in outdoor PM10 in winter was primarily due to an increase in the PM2.5 fraction. A similar seasonal variation was found for personal PM2.5. The high-risk subjects in our study engaged in an equal amount of dust-generating activities compared with the healthy elderly subjects. The children in the study experienced the highest indoor PM2.5 and PM10 concentrations. Personal PM2.5 exposures varied by study group, with elderly healthy and CHD subjects having the lowest exposures and asthmatic children having the highest exposures. Within study groups, the PM2.5 exposure varied depending on residence because of different particle infiltration efficiencies. Although we found a wide range of longitudinal correlations between central-site and personal PM2.5 measurements, the longitudinal r is closely related to the particle infiltration efficiency. PM2.5 exposures among the COPD and CHD subjects can be predicted with relatively good power with a microenvironmental model composed of three microenvironments. The prediction power is the lowest for the asthmatic children.
Production of Experimental Cholesterol-Induced Atherosclerosis in Chicks with Minimal Hypercholesterolemia and Organ Lipidosis
Authors: J. STAMLER, L. N. KATZ, C. Bolene
Journal: Circulation (1950)

Feeding chicks a mash enriched with 0.25 per cent cholesterol plus 5 per cent cottonseed oil induces a minimal sustained hypercholesterolemia. After 35 weeks of this regimen, birds exhibited a high incidence of gross cholesterol-induced atherosclerosis, particularly prominent in the thoracic aorta. The presence of atherosclerosis in these chicks with minimal diet-induced hypercholesterolemia lends further experimental support to the concept of the relationship of cholesterol in general, and exogenous cholesterol in particular, to the pathogenesis of human atherosclerosis.
A NEW TOWEL CLAMP
Authors: W. W. Nauth
Journal: JAMA (1926)

This instrument has certain advantages over those at present in use. Practically all towel clamps on the market today are constructed on either the scissor action or crossed spring action principle. With either construction, it is obvious that the handles or spring action act or operate in the same plane as that of the jaws, making it impossible to grasp the edge of the incised wound without either the instrument lying parallel and close to the incision or having the handles set at right angles to the body surface, thus interfering in either instance with the operator's work. The improvement embodied in this clamp consists of a construction which, when in use, will lie flat on the body surface, and at right angles to the incised wound. The downward curved upper member provides a method for grasping a much thicker section of the edge of the wound, at the
Development of a quantitative method for assessing epidermal regeneration
Authors: A. FOURTANIER, C. MEDAISKO, N. CHARLES, S. CARREIRO
Journal: British Journal of Dermatology (1984)

Journal Article Development of a quantitative method for assessing epidermal regeneration Get access A. FOURTANIER, A. FOURTANIER Laboratoire de Recherche L'Oréal, Aulnay‐sous‐Bois, France Search for other works by this author on: Oxford Academic Google Scholar C. MEDAISKO, C. MEDAISKO Laboratoire de Recherche L'Oréal, Aulnay‐sous‐Bois, France Search for other works by this author on: Oxford Academic Google Scholar N. CHARLES, N. CHARLES Laboratoire de Recherche L'Oréal, Aulnay‐sous‐Bois, France Search for other works by this author on: Oxford Academic Google Scholar S. CARREIRO S. CARREIRO Laboratoire de Recherche L'Oréal, Aulnay‐sous‐Bois, France Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 111, Issue s27, 1 July 1984, Pages 174–177, https://doi.org/10.1111/j.1365-2133.1984.tb15600.x Published: 01 July 1984
DERIVATION AND VALIDATION OF A RISK MODEL TO PREDICT THE PRESENCE AND EXTENT OF CORONARY ARTERY CALCIFICATION IN ASYMPTOMATIC INDIVIDUALS
Authors: Herman Feringa, Michael Blaha, Ron Blankstein, Juan Rivera, Matthew Budoff, Leslee Shaw, Paolo Raggi, Daniel Berman, Tracy Callister, Arthur Agatston, Roger Blumenthal, Harlan Krumholz, Khurram Nasir
Journal: Journal of the American College of Cardiology (2012)