tbuckley/cabot-search huggingface dataset:
Hemorrhage Into Pituitary Adenoma During Anticoagulant Therapy
Authors: Ali Reza Nourizadeh
Journal: JAMA (1965)

HEMORRHAGE into a pituitary adenoma is a well-known entity. Causes for this have been reported as roentgen irradiation, hypertension, arteriosclerosis, infarction, and hormone therapy; it has also been reported as a spontaneous occurrence.<sup>1,2</sup>We wish to report a case of hemorrhage into a pituitary adenoma which occurred during anticoagulant therapy. <h3>Report of a Case</h3> A 45-year-old white man was admitted to the medical service of the Hospital of the University of Pennsylvania on April 4, 1963, because of chest pain radiating to his left hand. The medical history was free of significant disease. There were no symptoms suggesting any disorder related to the eyes or endocrine system. On physical examination, blood pressure was 135/85 mm Hg. Examination of the head, eyes, ears, nose, and throat was normal. The chest was clear to auscultation, and there was no cardiomegaly. The cardiac rhythm was regular, and there were no murmurs. The
TTC21B contributes both causal and modifying alleles across the ciliopathy spectrum
Authors: Erica E Davis, Qi Zhang, Qin Liu, Bill H Diplas, Lisa M Davey, Jane Hartley, Corinne Stoetzel, Katarzyna Szymanska, Gokul Ramaswami, Clare V Logan, Donna M Muzny, Alice C Young, David A Wheeler, Pedro Cruz, Margaret Morgan, Lora R Lewis, Praveen Cherukuri, Baishali Maskeri, Nancy F Hansen, James C Mullikin, Robert W Blakesley, Gerard G Bouffard, Gabor Gyapay, Susanne Rieger, Burkhard Tönshoff, Ilse Kern, Neveen A Soliman, Thomas J Neuhaus, Kathryn J Swoboda, Hulya Kayserili, Tomas E Gallagher, Richard A Lewis, Carsten Bergmann, Edgar A Otto, Sophie Saunier, Peter J Scambler, Philip L Beales, Joseph G Gleeson, Eamonn R Maher, Tania Attié-Bitach, Hélène Dollfus, Colin A Johnson, Eric D Green, Richard A Gibbs, Friedhelm Hildebrandt, Eric A Pierce, Nicholas Katsanis
Journal: Nature Genetics (2011)
Robotic-Assisted Laparoscopic Radical Cystectomy and Intra-Abdominal Formation of an Orthotopic Ileal Neobladder
Authors: W.-D. Beecken, M. Wolfram, T. Engl, W. Bentas, M. Probst, R. Blaheta, A. Oertl, D. Jonas, J. Binder
Journal: European Urology (2003)
Vitamin B_12 Absorption Tests: An Evaluation.
Authors: Dalius J. Briedis
Journal: Annals of Internal Medicine (1972)

Meeting Abstracts1 May 1972Vitamin B12 Absorption Tests: An Evaluation.Dalius J. Briedis, Janifer Judisch, M.D., Henry N. Watner Jr., M.D., F.A.C.P., Patricia A. McIntyre, M.D., F.A.C.P.Dalius J. BriedisSearch for more papers by this author, Janifer Judisch, M.D.Search for more papers by this author, Henry N. Watner Jr., M.D., F.A.C.P.Search for more papers by this author, Patricia A. McIntyre, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-5-869_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe diagnosis of pernicious anemia (PA) by radioisotope tracer techniques depends on evidence of malabsorption of radioactive vitamin B12, which is improved by intrinsic factor (IF). In this study the dual isotope method for the diagnosis of pernicious anemia was evaluated. Thirty-seven patients and 74 control subjects were simultaneously given 0.5 μg of58Co-labeled free cyanocobalamin (B12) and 0.5 μg of [57Co] B12bound to normal human gastric juice. Twenty-four-hour urine specimens and 8-hour plasma specimens were obtained, and the isotopes were differentially counted. Patients with pernicious anemia showed significant differences between urinary excretions of the two isotopes, control subjects... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Dalius J. Briedis; Janifer Judisch, M.D.; Henry N. WatnerJr., M.D., F.A.C.P.; Patricia A. McIntyre, M.D., F.A.C.P.Affiliations: Baltimore, Md. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1972Volume 76, Issue 5Page: 869-869KeywordsBlood plasmaCyanocobalaminExcretionPernicious anemiaUrine ePublished: 1 December 2008 Issue Published: 1 May 1972 PDF downloadLoading ...
Impact of Time of Presentation on the Care and Outcomes of Acute Myocardial Infarction
Authors: Hani Jneid, Gregg C. Fonarow, Christopher P. Cannon, Igor F. Palacios, Teoman Kilic, George V. Moukarbel, Andrew O. Maree, Kenneth A. LaBresh, Li Liang, L. Kristin Newby, Gerald Fletcher, Laura Wexler, Eric Peterson
Journal: Circulation (2008)

Prior studies have demonstrated an inconsistent association between patients' arrival time for acute myocardial infarction (AMI) and their subsequent medical care and outcomes.Using a contemporary national clinical registry, we examined differences in medical care and in-hospital mortality among AMI patients admitted during regular hours (weekdays 7 am to 7 pm) versus off-hours (weekends, holidays, and 7 pm to 7 am weeknights). The study cohort included 62,814 AMI patients from the Get With the Guidelines-Coronary Artery Disease database admitted to 379 hospitals throughout the United States from July 2000 through September 2005. Overall, 33 982 (54.1%) patients arrived during off-hours. Compared with those arriving during regular hours, eligible off-hour patients were slightly less likely to receive primary percutaneous coronary intervention (adjusted odds ratio [OR], 0.93; 95% confidence interval [CI], 0.89 to 0.98), had longer door-to-balloon times (median, 110 versus 85 minutes; P<0.0001), and were less likely to achieve door-to-balloon < or = 90 minutes (adjusted OR, 0.34; 95% CI, 0.29 to 0.39). Arrival during off-hours was associated with slightly lower overall revascularization rates (adjusted OR, 0.94; 95% CI, 0.90 to 0.97). No measurable differences, however, were found in in-hospital mortality between regular hours and off-hours in the overall AMI, ST-elevated MI, and non-ST-elevated MI cohorts (adjusted OR, 0.99; 95% CI, 0.93 to 1.06; adjusted OR, 1.05; 95% CI, 0.94 to 1.18; and adjusted OR, 0.97; 95% CI, 0.90 to 1.04, respectively). Similar observations were made across most age and sex subgroups and with an alternative definition for arrival time (weekends/holidays versus weekdays).Despite slightly fewer primary percutaneous coronary interventions and overall revascularizations and significantly longer door-to-balloon times, patients presenting with AMI during off-hours had in-hospital mortality similar to those presenting during regular hours.
Prof. Philippe Godard, 1948–2011: Figure 1–
Authors: M. Gaga, G. Joos, P. Chanez
Journal: European Respiratory Journal (2011)

We were deeply saddened by the death of Philippe Godard, a passionate physician, educator and mentor, a dedicated family man, and a loyal and beloved friend. Philippe was a dedicated and active European Respiratory Society (ERS) member who served as ERS Assembly Secretary, a member of the ERS Executive Committee and Chair of the ERS School consecutively from 1994 to 2000.



Figure 1– 
Philippe Godard, 1948–2011.



Philippe Godard's career shows a constant professional dedication to his role as physician, teacher and researcher. After his medical diploma, and under the guidance of his mentor Prof. Francois B. Michel, he trained in France and Canada and specialised in pulmonary medicine, obtaining both the specialty certification and his medical doctorate in 1978. He then worked at the Faculty of Medicine of Montpellier (France), first at Aiguelongue, then at Arnaud de Villeneuve Hospitals and at INSERM (the French research centres). He also worked briefly in the USA, at Harvard University (Cambridge, MA), with Frank Austin. As Philippe used to say himself, his years of professional activity were intense, exciting and rewarding. His keywords were education, research and care.

Philippe loved his job as a clinician, as it embodied a social dimension that has largely developed into “community work” at a national and international level. …
How to prescribe antihistamines for chronic idiopathic urticaria: desloratadine daily <i>vs</i> PRN and quality of life
Authors: J.‐J. Grob, P. Auquier, I. Dreyfus, J.‐P. Ortonne
Journal: Allergy (2009)

Background: Chronic idiopathic urticaria (CIU) impairs quality of life (QoL). Currently, no consensus exists regarding how second‐generation H 1 ‐antihistamines (proven to control CIU symptoms) should be taken long‐term: as daily treatment or only when symptoms return (PRN). We sought to determine which regimen improves or better maintains QoL in CIU: desloratadine (DL) daily or PRN. Methods: Subjects with CIU initially responding to DL 5 mg/day for 4 weeks were randomized for an additional 8 weeks, to DL 5 mg/day (arm 1: ‘continuous’, n = 46) or to DL only on days when urticarial wheals were present (arm 2: “PRN”, n = 60). To ensure blinding, treatment was presented in both arms as a combination of daily treatment (arm 1: DL; arm 2: placebo), plus a “rescue” tablet (arm 1: placebo; arm 2: DL) to be taken only in case of symptoms. The main outcome measure was QoL assessed by the VQ‐Dermato, a validated French QoL instrument, and the Dermatology Life Quality Index (DLQI). Results: At 4 and 8 weeks after randomization, subjects taking continuous DL showed statistically significant improvements in VQ‐Dermato Global Index score ( P = 0.001 and P = 0.016, respectively) and dimension scores for daily living activity, mood state, and social functioning vs subjects taking DL PRN. Improvement in DLQI score at Week 4 was also significantly greater with continuous DL ( P = 0.001). Conclusion: Continuous daily therapy with DL 5 mg is a better regimen than PRN treatment to maintain or improve QoL in subjects with CIU.
Unexpected Left-Sided Pulmonary Aspiration Misdiagnosed as Malignancy in PET Cancer Screening Following Panendoscopy Cancer Screening Under Conscious Sedation
Authors: Chih-Hsiu Wang, Shung-Shung Sun, Te-Chun Hsieh, Kuo-Yang Yen, Yu-Chin Wu, Yu-Yi Lin, Chia-Hung Kao
Journal: Clinical Nuclear Medicine (2010)

We present 2 cases of incidental focal FDG-avid lesions in the left lung suspected to be malignancy on PET scan during cancer screening. Screening chest x-ray and CT performed on the day preceding a PET scan were unremarkable. Panendoscopy in the left decubitus position under conscious sedation was performed after CXR/CT and before PET. The lung lesions resolved spontaneously on follow-up chest CT and were thought to be due to aspiration during panendoscopy. PET should be scheduled before panendoscopy to avoid this false-positive finding. Otherwise, clinicians should be aware of the possibility of a FDG-avid lung finding resulting from possible silent aspiration.
1335 IL28B POLYMORPHISM IN HIV-POSITIVE PATIENTS WITH ACUTE HEPATITIS C
Authors: J. Nattermann, P. Ingiliz, A. Baumgarten, S. Mauss, I. Krznaric, M. Danta, U. Naumann, C. Boesecke, V. Soriano, J.K. Rockstroh, U. Spengler
Journal: Journal of Hepatology (2011)
Health Needs in Southeast Asia
Authors: Michael M. Stewart
Journal: JAMA (1973)

<h3>To the Editor.—</h3> As military activity in Indochina recently has given way to multilateral efforts to maintain a tenuous peace, attention has gradually turned to prospects for "health rehabilitation" for those countries that have suffered most from the long years of war and political and social unrest. Thailand's population of 38 million has been largely spared from direct involvement in the war. Nevertheless, familiarity with the health needs of Thailand, and with the deficiencies of the national health care system that is struggling to meet those needs, may help to put into perspective the health needs of those neighboring countries more directly involved. Thailand is usually counted among the "developing nations," ie, it is poor by Western standards. Annual per capita income is approximately $180 (United States). The population growth rate of 3% per year is primarily due to a high birth rate (42 per 1,000) and recently lowered infant
A larger number of L chains (Tac) enhance the association rate of interleukin 2 to the high affinity site of the interleukin 2 receptor.
Authors: Y Saito, H Sabe, N Suzuki, S Kondo, T Ogura, A Shimizu, T Honjo
Journal: The Journal of Experimental Medicine (1988)

The IL-2-R is composed of at least two proteins, that is, a 55-kD protein (p55, the L chain, or Tac) and a 75-kD protein (p75, the H chain, or converter). The high affinity binding of IL-2 results in the formation of the ternary complex consisting of IL-2, and the L and H chains. To distinguish the affinity conversion model and the binary complex model we have carried out kinetic studies on the IL-2 binding to the high affinity IL-2-R on T lymphocytes expressing various numbers of L chains and a relatively constant number of H chains. We found that expression of a larger number of L chains accelerated the association of IL-2 to the high affinity receptor. The results are not compatible with the binary complex model that assumes a fixed number of high affinity sites determined by the numbers of a limiting chain. Instead, the results are consistent with the prediction of the affinity conversion model that assumes association of IL-2 to the L chain as the first step of the ternary complex formation and they indicate that the possible role of excess L chains is to accelerate the formation of the ternary complex. The reaction rate constants calculated from the affinity conversion model were reasonably constant.
Implementation of Evidence-Based Therapies for Myocardial Infarction and Survival
Authors: Debabrata Mukherjee
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Intensity of<sup>18</sup>Fluorodeoxyglucose Uptake in Positron Emission Tomography Distinguishes Between Indolent and Aggressive Non-Hodgkin’s Lymphoma
Authors: Heiko Schöder, Ariela Noy, Mithat Gönen, Lijun Weng, David Green, Yusuf E. Erdi, Steven M. Larson, Henry W.D. Yeung
Journal: Journal of Clinical Oncology (2005)

Purpose 18 Fluorodeoxyglucose positron emission tomography (FDG PET) is widely used for the staging of lymphoma. We investigated whether the intensity of tumor FDG uptake could differentiate between indolent and aggressive disease. Materials and Methods PET studies of 97 patients with non-Hodgkin's lymphoma who were untreated or had relapsed and/or persistent disease and had not received treatment within the last 6 months were analyzed, and the highest standardized uptake value (SUV) per study was recorded. Correlations were made with histopathology. Results FDG uptake was lower in indolent than in aggressive lymphoma for patients with new (SUV, 7.0 ± 3.1 v 19.6 ± 9.3; P &lt; .01) and relapsed (SUV, 6.3 ± 2.7 v 18.1 ± 10.9; P = .04) disease. Despite overlap between indolent and aggressive disease in the low SUV range (indolent, 2.3 to 13.0; aggressive, 3.2 to 43.0), all cases of indolent lymphoma had an SUV ≤ 13. A receiver operating characteristic (ROC) analysis demonstrated that the SUV distinguished reasonably well between aggressive and indolent disease (area under ROC curve, 84.7%), and an SUV &gt; 10 excluded indolent lymphoma with a specificity of 81%. With a higher cutoff for the SUV, the specificity would have been higher. Conclusion FDG uptake is lower in indolent than in aggressive lymphoma. Patients with NHL and SUV &gt; 10 have a high likelihood for aggressive disease. This information may be helpful if there is discordance between biopsy and clinical behavior.
A NEW OBSTETRIC FORCEPS AND AN AXIS-TRACTION FORCEPS.
Authors: A. B. SPÄCH
Journal: JAMA (1897)

In theJournalof December 1896, I published a description of a "New Obstetric Forceps." In response to numerous requests for a detailed account of the axis-traction features of my forceps and under this stimulus, I have added to and recast what has already been published, making the description entirely a new one. A glance at Fig. 1 reveals the forceps with two circles described around it, having a common center, which is at the lock. A sector of the larger circle is formed by the blades and an arc of the same circle. Another is formed, by the handles and an arc of the smaller circle, or an equal one by the blades and an arc of the same circle passing through the blades, where they are farthest apart. Thus, as the blades are separated, the distances between them are accurately read off on the handle of the lower
Bilateral posterior dislocation of shoulders.
Authors: N. E. Miller
Journal: BMJ (1969)

MEDIBALJOURNALfor established left ventricular failure or given in the late afternoon to prevent par- oxysmal nocturnal dyspnoea.The need for potassium supplements is governed by many factors, such as the potassium content of the diet, the presence or absence of primary or more commonly secondary hyperaldosteronism.It must be remembered that severe sodium restriction is a powerful stimulant to aldosterone secretion; therefore, if dietary sodium is restricted, potassium supplements are likely to be needed.Finally, Dr. Susan Cotton and IP did not report occasional evidence of mild liver dys- function in patients treated with guanoxan, but five cases of frank hepatitis with jaundice, one of them fatal, in addition to laboratory evidence suggestive of hepatic dysfunction in a third of the first 100 treated patients.-I am, etc., E. MONTUSCHU.
Abstract 4848: Genetic profile of invasive breast cancer vasculature using laser capture microdissection (LCM) to capture vessels
Authors: Dylan T. Jones, Tanguy Lechertier, John Herbert, Roy Bicknell, Louise J. Jones, Adrian L. Harris, Kairbaan Hodivala-Dilke
Journal: Cancer Research (2011)

Abstract Tumor angiogenesis is vital for tumor growth and progression. Defining genes that are involved in tumor driven angiogenesis may yield therapeutically important targets for cancer therapy. We have developed and optimized a rapid 25 minute immunohistochemical staining method using CD31 antibody (Pecam1) specific to endothelial cells in vessels on sections from frozen human breast cancer (n=3) and normal breast (n=3), followed by laser capture microdisection (LCM) of vessels. Good quality RNA was extracted amplified, and fluorescently labeled cDNA was synthesized and hybridized onto Affymetrix U-133 Plus 2.0 array. Using this methodology, we were able to elucidate the genetic profile of tumor associated vessels from invasive breast cancer and compare it with vessels in normal breast tissue. This technique has the advantage over other methods in analyzing genetic profile of tissue as it analyses the genetic profile of isolated cell population and eliminates genes expressed by surrounding tissue, allowing for the detection of low expression of genes that were not detected in whole tumor arrays. Using false discovery rate statistical analysis (q&amp;lt;0.05) of microarray data, we identified 64 upregulated and 6 downregulated genes in breast cancer associated vessels. With Ingenuity Pathway analysis the top molecular and cellular functions include 11 genes involved in Cellular Assembly and Organization, 9 in Cellular Function and Maintenance and 8 in Protein Synthesis. Canonical pathway analysis revealed 3 genes involved in Ephrin Receptor signaling, 3 in Integrin signaling, 2 in VEGF signaling and 2 in TGF-β signaling. Differentiated genes were compared to Expression Sequence Tags from endothelial and non-endothelial libraries; three genes were specific to endothelial cells only (q&amp;lt;0.05). Using Immunohistochemistry we have validated expression of two genes in breast vessels. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4848. doi:10.1158/1538-7445.AM2011-4848
The Young Adult with Diabetes: Impact of the Disease on Marriage and Having Children
Authors: Janet E Ahlfield, Norman G Soler, Spencer D Marcus
Journal: Diabetes Care (1985)

To investigate the impact of insulin-dependent diabetes mellitus on marriage and having children we studied 50 young adults (aged 20-35 yr) with onset of the disease less than 20 yr. The subjects studied (37 women and 13 men) included 17 single, 26 married, and 7 divorced/separated diabetic patients. Twenty-two spouses of the 26 married diabetic patients also participated in the study. A 35-item questionnaire was developed with a 4-point Likert scale format for responses and administered separately to the patients and their spouses. None of the young adults in this study had made a conscious decision to remain unmarried, but 14 of 50 had decided not to have children. Onset of diabetes before 9 yr was associated with a significantly higher marriage rate than later onset of diabetes. Although onset of the disease after age 13 yr was more often associated with a decision to remain childless compared with earlier onset, this difference was not significant. Both men and women with diabetes found that the disease had an impact on certain aspects of their marital life, at times leading to friction and causing a financial burden. Whereas spouses were perceived to be very supportive, there was disagreement between young diabetic subjects and their spouses as to the impact of the disease on family activities and finances, the partners with diabetes perceiving a greater effect on these aspects of their lives than did their spouses.
THE TREATMENT OF DIABETES WITH INSULIN
Authors: FREDERICK M. ALLEN
Journal: JAMA (1923)

Within the limits of a brief paper it is possible to give only a brief summary of our methods and results to date, and refer to our former publications 1 for details. Many statements are intentionally phrased as opinions or beliefs, because the experiences are still too brief to be conclusive, and time will be necessary for a final decision.  METHODS  Purpose.  —The purpose of insulin treatment is to improve the nutrition of patients with severe diabetes, and to add a safeguard against downward progress. Mild cases, which can be kept symptom-free on adequate diets, ordinarily do not require insulin. Insulin does not offer a cure of diabetes or a license for carelessness. We understand as part of the purpose that every patient is to be kept sugar-free. The question, Why should this be done? can be partly met by the counterquery, Why should it not be done? since others