tbuckley/cabot-search huggingface dataset:
Metabolic Effects of Theophylline
Authors: DOMINIQUE C. PAGNIEZ
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 February 1986Metabolic Effects of TheophyllineDOMINIQUE C. PAGNIEZ, M.D., EVELYNE MACNAMARA, M.D., PHILIPPE DEQUIEDT, M.D., ALBERT TACQUET, M.D.DOMINIQUE C. PAGNIEZ, M.D.Search for more papers by this author, EVELYNE MACNAMARA, M.D.Search for more papers by this author, PHILIPPE DEQUIEDT, M.D.Search for more papers by this author, ALBERT TACQUET, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-104-2-284_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Kearney and colleagues (1) state that toxic levels of theophylline were associated with hypokalemia, hyperglycemia, and metabolic acidosis in a patient and in four anesthetized dogs. We report a similar case.A 24-year-old man was hospitalized 3 hours after ingesting 9 grams of a long-acting theophylline preparation (Euphylline; Laboratoires Valpan, Le Mée sur Seine, France) and 300 mg of clorazepate. He was drowsy but had no seizure. Blood pressure was never less than 80/60 mm Hg, and chest findings and radiographs were always normal. On admission, blood gas analysis showed pH, 7.32; Po2, 62 mm Hg; Pco2,...References1. KEARNEYMANOGUERRACURTISZIEGLER TAGM. Theophylline toxicity and the beta adrenergic system. Ann Intern Med. 1985;102:766-9. LinkGoogle Scholar2. COHENKASSIRER JJ. Acid-base metabolism. In: MAXWELL MH, KLEEMAN CR, eds. Clinical Disorders of Fluid and Electrolyte Metabolism. 3rd ed. New York: McGraw-Hill Book Co. ; 1980:224-5. Google Scholar3. DREISBACH R. Handbook of Poisoning. 10th ed. Los Altos, California: Lange Medical Publications; 1980:410. Google Scholar4. GOODKINKRISHNANARINS DGR. The role of the anion gap in detecting and managing mixed metabolic acid-base disorders. Clin Endocrinol Metab. 1984;13:333-51. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Hôpital Albert Calmette 59037 Lille Cedex France PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySIADH and Hyponatremia with Theophylline 1 February 1986Volume 104, Issue 2Page: 284-284KeywordsAcidosisBloodBlood pressureEpileptic seizuresGas analysisHyperglycemiaPartial pressure of carbon dioxidePartial pressure of oxygenThorax Issue Published: 1 February 1986 PDF downloadLoading ...
SIROLIMUS–ELUTING STENT IMPLANTATION FOR OSTIAL VERSUS NON–OSTIAL PROXIMAL RIGHT CORONARY ARTERY LESIONS: FIVE–YEAR OUTCOME FROM THE J–CYPHER REGISTRY
Authors: Euihong Ko, Masahiro Natsuaki, Takeshi Morimoto, Mamoru Toyofuku, Takashi Tamura, Takeshi Kimura
Journal: Journal of the American College of Cardiology (2013)
Treatment of delusional parasitoses
Authors: D. J. White
Journal: JAMA (1997)

To the Editor.  —Ms Lamberg 1 addressed several important issues related to delusional parasitoses. I would like to contribute another potential source of patient discomfort that may need to be included during a patient's medical history review.  As director for the Arthropod-borne Disease Program for the New York State Health Department, I have had perhaps 20 patients referred to me in recent years by phone or even personal visit from physicians caring for patients who present with complaints of unverifiable infestations, but for whom examinations for valid infestations such as scabies have proven negative or have not been pursued.  I have used a fairly standard approach toward these patients (typically older women) to elicit information that may serve to explain their sensations of parasitosis (itching, crawling, often with pinprick biting sensations). Often they will refer to, or arrive with, tiny worms or parasites collected on adhesive tape, plastic bags, or even vacuum bags!
Regulation of transferrin receptors by iron in human erythroblasts
Authors: Yasunobu Abe, Koichiro Muta, Junji Nishimura, Hajime Nawata
Journal: American Journal of Hematology (1992)

We investigated the regulatory mechanism of human erythroblast transferrin receptors (Tf.R) under conditions of iron deprivation and iron loading. Treatment of erythroblasts with an iron chelator, desferrioxamine, induced an increase in surface Tf.R number associated with an elevation of biosynthetic rate and the mRNA level of Tf.R. Reduced cellular iron pool increased the Tf.R number by altering the level of mRNA, as in nonhemoglobin-producing cells. Although treatment of erythroblasts with hemin induced a decrease in the biosynthetic rate and in the level of mRNA, the number of surface Tf.R did not decrease. This phenomenon may explain the fact that a high level of serum iron has no influence on the surface Tf.R number in vivo, as we reported previously. We suggest the existence of a regulatory mechanism specific for hemoglobin-producing cells that keeps surface Tf.R expression constant despite iron loading.
The Unreached Patient
Authors: Michael M. Stewart
Journal: JAMA (1973)

To  Editor.—  The editorial by Brickner (225:1645, 1973), entitled Finding  Unreached Patient, dealt eloquently with a specific issue, the isolated, homebound, aged, but also raised, by implication, additional generically related problems.  In  midst of  current wave of interest in family practice, primary care, ambulatory services, and community medicine—in short, in nonhospitalized persons—have adequate methods been devised to identify target populations for such programs?  Resources available for health care and medical care will always be limited. Perfect health for all people of all ages is a fantasy. The right to good health must be realized within finite constraints. Who in  community has highest priority? By what mechanism should specific target groups in need be identified and ranked? To what degree should  identified needs of one sub-group be weighed against  probable but poorly documented needs of another sub-group?  Should outreach programs with limited resources be
Beneficence: doing good for others.
Authors: R Gillon
Journal: BMJ (1985)

Gillon's essay on beneficence is one in a series of British Medical Journal articles on philosophical medical ethics. The duty of beneficence, or doing good for others, figures more prominently in medicine than in most other professions. As important as beneficence is in the physician patient relationship, however, it must be tempered by respect for the patient's autonomy; by the duty of nonmaleficence, or of doing no harm; and by a concern for justice, especially in the allocation of scarce medical resources.
Prescription of heroin to treatment resistant heroin addicts: Heroin handouts are flawed policy
Authors: E. A Voth
Journal: BMJ (2004)

Diagnosis of autism Adequate funding is needed for assessment services2][3] One important additional reason for such provision, which their review does not emphasise, is that well coordinated, multiagency assessment teams for autism spectrum disorders have a better chance of accurately not giving a diagnosis of it.Our multiagency assessment service for autism spectrum disorders has seen 57 patients in the past two years.We request baseline speech and language therapy and (where applicable) educational psychology assessments on the likelihood of autism spectrum disorder in all cases before patients are seen by our team, so as to ensure best use of clinical resources.Despite this approach only 26 patients (46%) deemed to be likely cases of autism spectrum disorder received a positive diagnosis.This is not due to overzealous interpretation of ICD-10 diagnostic criteria (which are increasingly recognised as being in urgent need of review), as we tend, if anything, to err in favour of diagnosis, even if ICD-10 (or DSM-IV) criteria, are not strictly fulfilled.Relevant agencies must receive adequate funding for implementing the national autism plan for children. 3This is to benefit not only the children and their families who are struggling with the often devastating impact of this disorder but also the depressingly high number of children whom, we suspect, will be wrongly, or inaccurately, given diagnoses, if assessment services for autism spectrum disorders do not improve.
ROLE OF RIGHT VENTRICLE AND PULMONARY HYPERTENSION ON DETERMINING ΔVO2/ΔWORK RATE FLATTENING: INSIGHTS FROM CARDIOPULMONARY EXERCISE TEST COMBINED WITH EXERCISE ECHOCARDIOGRAPHY
Authors: Francesco Bandera, Greta Generati, Marta Pellegrino, Valeria Donghi, Eleonora lfonzetti, Gaeta Maddalena, Simona Villani, Marco Guazzi
Journal: Journal of the American College of Cardiology (2014)
Informed consent for genetic research on blood stored for more than a decade: a population based study
Authors: B. Stegmayr
Journal: BMJ (2002)

Education and debate p 648

With recent advances in molecular genetics, there has been a surge in interest in using stored blood samples for genetic research, even though informed consent at the time of blood sampling did not include this possibility. One of the cornerstones of the World Medical Association's Declaration of Helsinki on ethical principles for medical research is the need for informed consent and the right of any participant in a research project to withdraw at any time.1 We report here our experiences of seeking informed consent for academic and commercial genetic research on blood samples collected more than a decade earlier.

A total of 1583 out of 2000 (79.2%) randomly selected men and women in the age group 25-64 years participated in the 1990 risk factor survey in the World Health Organization's …
Early viral kinetics of hepatitis C virus (HCV) genotype 3 with very frequent sampling analysis
Authors: J.E.M. Medeiros-Filho, J.R.R. Pinho, A.U. Neumann, I.M.V.G.C. Mello, M.F. Lemos, L.C. Da Silva, A.A. Laudanna, F.J. Carrilho
Journal: Journal of Hepatology (2002)
Effect of Albumin Binding on Extraction of Sulfobromophthalein by Perfused Elasmobranch Liver: Evidence for Dissociation-Limited Uptake
Authors: Richard A. Weisiger, Charles M. Zacks, Neil D. Smith, James L. Boyer
Journal: Hepatology (1984)

We investigated the role of serum albumin in the hepatic uptake of organic anions by determining the effect of added bovine albumin on sulfobromophthalein (BSP) uptake in skates, an animal which naturally lacks this protein. A single-pass perfused liver model was used to determine steady-state net uptake rates as the BSP or BSP and albumin concentrations were systematically varied. Results indicated that two different steps in the uptake process are capable of limiting the uptake rate depending on the albumin and BSP concentrations selected. At higher rates of uptake corresponding to higher BSP concentrations (up to 112 μM ), saturation kinetics were observed as the BSP concentration was varied, with apparent K ra and V max values which were independent of the albumin concentration (0.05 to 0.75%). These data suggest that under these conditions uptake is limited by a saturable step intrinsic to the liver. In contrast, for lower BSP concentrations and albumin concentrations below about 0.5%, a different kinetic pattern was seen which suggested that the rate-limiting step in uptake was transfer of BSP from albumin to the liver. The latter data were found to be consistent with a model in which the limiting step in the transfer process is spontaneous dissociation of the BSP from binding sites on albumin within the sinusoid. These results suggest that skate liver clears BSP from albumin solutions by a two-step mechanism in which dissociation from albumin is followed by a saturable process consistent with carrier-mediated transport. The albumin concentration and uptake velocity are important factors in determining which of these steps limits the uptake rate. Clearance is efficient and irreversible even though elasmobranch liver lacks high-affinity cytosolic binding proteins for BSP, and elasmobranch plasma does not normally contain albumin.
Multiple Myeloma in the Young
Authors: BONG HAK HYUN
Journal: Annals of Internal Medicine (1976)

Comments and Correction1 August 1976Multiple Myeloma in the YoungBONG HAK HYUN, M.D., D.SC.(MED)BONG HAK HYUN, M.D., D.SC.(MED)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-85-2-260 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: A recent paper by G. M. Hewell and R. Alexanian in this journal (1) reporting the cases of three young men, aged 17 to 22 years, found to have multiple myeloma prompts us to make some comments.The authors state that their cases are the first well-documented examples of multiple myeloma in patients younger than the age of 30. Obviously they failed to find our 1973 report (3) of a well-documented case of myeloma.A 13-year-old girl had tumor masses in the breast as the initial manifestation. Bone-marrow examination showed 100% cellularity with more than 90% of...References1. HEWELLALEXANIAN GR: Multiple myeloma in young persons. Ann Intern Med 84:441-443, 1976 LinkGoogle Scholar2. MAEDAABESAMISKUHN KCL: Multiple myeloma in childhood: report of a case with breast tumors as a presenting manifestation. Am J Clin Pathol 60:552-558, 1973 CrossrefMedlineGoogle Scholar3. BERKHEISER E: Multiple myeloma of children. Arch Surg 9:853-881, 1924 CrossrefGoogle Scholar4. GILMORE M: Multiple myeloma syndrome in a child. Tex State J Med 21:358-362, 1925-1926 Google Scholar5. GORDONSCHNEIDER HB: Plasma cell myeloma in a child, Int Clin 4:173, 1940 Google Scholar1. RUBINSTEIN M: Multiple myeloma as a form of leukemia. Blood 4:1049-1067, 1949 CrossrefMedlineGoogle Scholar2. ALEXANIANBALCERZAKBONNET RSJ: Prognostic factors in multiple myeloma. Cancer 36:1192-1201, 1975 CrossrefMedlineGoogle Scholar3. DURIESALMON BS: A clinical staging system for multiple myeloma. Cancer 36:842-854, 1975 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1976Volume 85, Issue 2Page: 260-261KeywordsMultiple myelomaMyeloma ePublished: 1 December 2008 Issue Published: 1 August 1976 PDF downloadLoading ...
Marfan's Syndrome and Other Disorders of Fibrillin
Authors: Uta Francke, Heinz Furthmayr
Journal: New England Journal of Medicine (1994)

Marfan's syndrome is classically defined as an autosomal dominant disorder of connective tissue with variable manifestations involving primarily the cardiovascular, ocular, and musculoskeletal systems. The most important feature that reduces life expectancy is progressive dilatation of the aortic root and ascending aorta, leading to aortic-valve incompetence and aortic dissection. Aortic dilatation and dissection, however, do not always occur together. In some families, dissection tends to occur before the aorta has reached the critical diameter of 55 mm, currently considered an indication for prophylactic surgery in adults. Repair of the aortic valve and ascending aorta with a composite graft has made . . .
Protein Content in Lymph and Edema Fluids in Congestive Heart Failure
Authors: CHARLES L. WITTE, MARLYS HEARST WITTE, ALLAN E. DUMONT, WILLIAM R. COLE, JOHN R. SMITH
Journal: Circulation (1969)

Protein content of tissue fluid and lymph is not uniform and depends upon regional differences in capillary permeability modified by changes in capillary filtration pressure. Whereas increased pressure in freely permeable liver sinusoids promotes formation of excess liver and thoracic duct lymph and ascitic fluid high in protein, increased venous pressure in less permeable beds promotes formation of excess lymph and edema fluid progressively lower in protein content. To ascertain the influence of colloid osmotic (oncotic) and hydrostatic pressure on excess lymph and edema formation in congestive heart failure, a disorder characterized by generalized venous hypertension, protein content of lymph (thoracic duct, liver, and small intestine), intracavitary and peripheral edema fluid, and plasma were measured in 42 patients with cardiac failure. In "acute" heart failure, thoracic duct lymph and ascitic fluid have high protein content (85% and 68% of plasma protein respectively) and are derived primarily from the liver, but in "chronic" heart failure protein content of thoracic duct lymph and ascitic fluid are lowered (46% and 40% of plasma protein respectively) by lymph from extrahepatic sites. In both stages, pleural and leg edema fluid are comparatively low in protein content (26 to 44% and 3 to 8% of plasma protein respectively). In congestive heart failure, edema and intracavitary fluid form primarily in response to increased venous pressure which outside the liver is partially counterbalanced by increased effective plasma oncotic pressure.
THE INFLUENCE OF VARIOUS SUBSTANCES ON THE GROWTH OF MOUSE CARCINOMA
Authors: Moyer S. Fleisher, Leo Loeb
Journal: The Journal of Experimental Medicine (1914)

We have described the methods used in determining the influence of certain substances on tumor growth, and we measured approximately the degree of reliability of the quantitative method used. We examined with these methods various classes of substances,- distilled water, a number of inorganic salts, inorganic colloidal substances, various organic colloidal and non-colloidal substances, especially various proteids, tuberculin and hirudin alone as well as in combination with other substances. Distilled water, various inorganic sulphur preparations, and various inorganic salts did not show an inhibiting effect on tumor growth sufficient to be detected by means of our first method. Only in the case of gold potassium cyanide was there possibly a slightly retarding influence present. On the other hand, certain colloidal solutions of heavy metals (copper, platinum, gold) retard the growth of a number of tumors of injected animals. Certain combinations of copper salts and casein act in a similar manner. Of the organic substances used, casein, nucleoproteid, and hirudin were active, while the other proteids tested, as well as various other organic substances and tuberculin and lecithin, seemed to be either without effect or weaker than the other substances mentioned as retarding the tumor growth. Hirudin was active and caused in addition to its inhibiting influence the retrogression of a certain number of tumors. Especially active was a combination of hirudin with colloidal copper and of hirudin with nucleoproteid. One single injection of casein or nucleoproteid, or of the Heyden preparation of colloidal copper, leads to a more or less marked edematous condition of a certain number of tumors, while hirudin caused in addition, in many cases, marked hemorrhages in or around the tumors. Other substances which we tested did not show this effect, although their inhibiting action on tumor growth may have been equally strong. Very young tumors (two to six days old) are not retarded in their growth through injection of colloidal copper or hirudin, while nine to thirteen days old tumors are, independently of their size on the ninth day, inhibited in approximately the same relative degree; absolutely, however, the more rapidly growing smaller tumors are more markedly inhibited than the normally more slowly growing larger tumors.
Role of Radionuclide Shunt Studies in Management of Infants and Children
Authors: ROGER A. HURWITZ, RANDALL L. CALDWELL, LYNN MAHONY, DONALD A. DIROD, HENRY WELLMAN
Journal: Clinical Nuclear Medicine (1986)

The utility of radionuclide-shunt quantitation in children was assessed by examination of the outcome of 128 patients who underwent shunt study over a two-year period. The possibility of cardiac catheterization was eliminated in 87. Fifty of these had undergone previous cardiac catheterizations, which suggested the necessity for further invasive study or surgery; after radionuclide evaluation, 28 were shown to have had enough spontaneous closure of the defect to cancel planned surgery, 12 were scheduled for surgery without repeat catheterization, and ten had nuclear rather than catheterization estimates of residual shunting following surgical repair of septal defects. Thus, radionuclide shunt study provides a relatively noninvasive technique to quantitate left-to-right shunts, supplementing or supplanting cardiac catheterization in the management of infants and children with such lesions.
Thermoplastic Stents: A New Concept for Endoluminal Prosthesis
Authors: S. Freudenberg, M. Hartel, F. Fernandez, K. L. Schuster, V. Kammermaier, J. Haberstroh, J. Schmoll, B. C. Manegold, J. Hasse
Journal: Endoscopy (2002)

Background and Study Aims: Intraluminal stenting of organs with stenoses or fistulae in anatomically difficult locations (for instance cardia, pylorus, large bowel), with a tendency to kinking or increased motility, still carries a high risk of stent dislocation. In the search for a solution, we report on the use of a new thermoplastic stent in animal experiments.
“Practice Makes Perfect”…or Does It?
Authors: Richard L. Neubauer
Journal: Annals of Internal Medicine (2005)

Letters5 July 2005“Practice Makes Perfect”…or Does It?Richard L. Neubauer, MDRichard L. Neubauer, MDFrom Anchorage, AK 99508.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-143-1-200507050-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I read with great interest the editorial “‘Practice Makes Perfect’…or Does It?” (1). I am heartened by the collaborative spirit expressed by Dr. Weinberger, who represented the American College of Physicians (ACP), and Drs. Duffy and Cassel, who represented the American Board of Internal Medicine (ABIM). I agree with the shared visions expressed and the goal of identifying ways to “maintain the highest quality of care throughout a career that spans several decades.” I further agree that maintenance of certification is a tool that has great potential toward furthering the stated goal.I also have a nagging ...Reference1. Weinberger SE, Duffy FD, Cassel CK. “Practice makes perfect”…or does it? [Editorial]. Ann Intern Med. 2005;142:302-3. [PMID: 15710964] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Anchorage, AK 99508.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee Also“Practice Makes Perfect” … Or Does It? Steven E. Weinberger , F. Daniel Duffy , and Christine K. Cassel “Practice Makes Perfect”…or Does It? Ira Daniel Breite “Practice Makes Perfect”…or Does It? Steven E. Weinberger , F. Daniel Duffy , and Christine K. Cassel Metrics 5 July 2005Volume 143, Issue 1Page: 87KeywordsConflicts of interestEmotionsHealth care qualitySub-specialty careVision ePublished: 5 July 2005 Issue Published: 5 July 2005 Copyright & PermissionsCopyright © 2005 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...