Hypocalcemia and Hypophosphatemia Accompanying Osteoblastic Osseous Metastases: Studies of Calcium and Phosphate Metabolism and Parathyroid Function.
Authors: G. D. Ludwig
Journal: Annals of Internal Medicine (1962)

s1 April 1962Hypocalcemia and Hypophosphatemia Accompanying Osteoblastic Osseous Metastases: Studies of Calcium and Phosphate Metabolism and Parathyroid Function.G. D. Ludwig, M.D.G. D. Ludwig, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-56-4-676_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe medical literature contains few reports of hypocalcemia accompanying osteoblastic osseous metastases, and the combination of hypocalcemia and hypophosphatemia accompanying such lesions has not been described previously. Five patients displaying hypocalcemia in association with osteoblastic metastases form the substance of this report. Two of them, whose primary lesions were carcinoma of the prostate gland, also had marked hypophosphatemia, and, in both, estrogen therapy appeared to induce the hypocalcemia and hypophosphatemia. A third patient having osteoblastic metastases from prostate carcinoma also developed hypocalcemia only after estrogenic therapy, but the serum phosphate remained normal. The other two patients, who were never given... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pa. (CI) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBiomarkers of Prostatic Cancer: An Attempt to Categorize Patients into Prostatic Carcinoma, Benign Prostatic Hyperplasia, or Prostatitis Based on Serum Prostate Specific Antigen, Prostatic Acid Phosphatase, Calcium, and PhosphorusProlonged hypocalcemia following denosumab therapy in metastatic hormone refractory prostate cancerThe calcimimetic R-568 induces apoptotic cell death in prostate cancer cellsBone metastases as a cause of hypocalcaemiaHypocalcemia and Parathyroid Function in Metastatic Prostate CancerMiliary Osteosarcomatosis with Associated HypocalcemiaA Hospital Survey of Hypocalcemia and Hypophosphatemia in MalignancyStudies of the Endocrine and Paracrine Effect of Tumor Produced Factors in Human Genitourinary CancersHypocalcemia in cancerThe clinical spectrum of hypocalcaemia associated with bone metastasesHypocalcemia Associated with Estrogen Therapy for Metastatic Adenocarcinoma of the ProstateParaneoplastic Syndromes Associated with Prostatic CarcinomaBiochemical Picture Accomapanying Sclerotic Bone Metastases of Prostatic Origin*Sr-89 therapy: Strontium kinetics in disseminated carcinoma of the prostateHuman Prostate Carcinoma Causes Hypercalcemia in Athymic Nude Mice and Produces a Factor with Parathyroid Hormone-Like BioactivityA Hospital Survey of Hypocalcemia in Patients with Malignant DiseaseDecreased serum phosphate levels after high-dose estrogens in metastatic prostate cancerProfound hypocalcaemia associated with oestrogen treatment of carcinoma of the prostateSpread of prostatic cancer to boneOsteomalacia associated with prostatic cancer and osteoblastic metastasesHow and what kind of bone is made by metastatic cells of prostatic cancerHypocalcemia with osteoblastic metastases in a patient with prostate carcinomaHypophosphatemic Osteomalacia: Association with Prostatic CarcinomaKENNETH W. LYLES, M.D., WILLIAM R. BERRY, M.D., MARK HAUSSLER, Ph.D., JOHN M. HARRELSON, M.D., MARC K. DREZNER, M.D.Disorders of Mineral Metabolism in MalignancyHypocalcemia resulting from calcium accretion by a chondrosarcomaOsteoblastic metastases in small-cell (OAT-cell) carcinoma of the lungSecondary malignant tumors of the parathyroid glandsHypocalcemia — An Unusual Metabolic Complication of Breast Cancer 1 April 1962Volume 56, Issue 4Page: 676-677KeywordsCalciumEstrogensHypocalcemiaLesionsParathyroidPhosphatesProstate gland Issue Published: 1 April 1962 PDF downloadLoading ...