tbuckley/cabot-search huggingface dataset:
Hyper-induction of skin ornithine decarboxylase activity in psoriatic patients
Authors: M. BOUCLIER, P. ELBAZE, G. MILANO, B. SHROOT, J-P. ORTONNE
Journal: British Journal of Dermatology (1986)

Ornithine decarboxylase activity was measured in skin from 14 normal and 24 psoriatic subjects (with stable plaque type psoriasis vulgaris) using punch biopsies carried out immediately (o h) and 6 h after stimulation by cellotape stripping. At o h, no significant difference was found between normal and involved or uninvolved psoriatic skin, but a significant increase was measured 6 h after tape stripping. This increase was significantly greater in uninvolved and involved psoriatic skin compared with normal skin. Preliminary results indicated that these changes were localized in the epidermis.
View From a Room
Authors: Thomas L. Warren
Journal: JAMA (1990)

I may forget a few patients over the years, fail to recall their faces, their specific diseases, their complications, but if you mention one of the 24 rooms on 4 North, the medical oncology floor, a flood of names will rush before me. I don't know why, but I usually shun the superstitious—the uncanny occurrences of life. I never felt I had to use the same bat in Little League or the same pencil during a test, or even to pick lottery numbers of a certain significance. But it seems that a few rooms on 4 North definitely have it in for me. Whenever I enter one of these rooms, pushing through the oversized, intentionally heavy doors, I feel deep within my gut that the victim inside will touch me, teach me, sense me, in a manner no other one would in some different room. These certain rooms will play host to a human being I will come to know, to hold his hand while a resident performs some painful but hopefully necessary procedure, or perhaps share his grief, his foreboding of that inevitable event, through mutual tears. But eventually I will have to walk once again to the medical supply room, to find a small plastic bag containing
Je Vais le Faire
Authors: Joshua C. Ziperstein
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Hunterian Oration on THE PROGRESS OF SURGERY FROM HUNTER'S DAY TO OURS
Authors: H. Waring
Journal: BMJ (1928)

anid Genitlemen, e celebrate the two hundredth anniversary of the biirtlh of Johln Hunter, the foinmder of modern scientific surgery, the creator of our Museum, ancd the latron saint of our College.Sinice 1814 an oration-the Hulnterian Orationl-hlas been given, at first annu-ally and theni, after 1855, biceniailly-, in this College in lhis Plemoi-v.A large proportion-i of these oirations have dealt witlh onie or more of the nlumer ous brarches of Hulnter's activities; in fact, it lhas always seemed to nme that thiere is scarcely anv pIart of the work of Hunter which lhas not been collmmemnor ated in one way oi-another at onie of these orations.On examiningo, the conditions as given in the trust deed PROGRESS OF SURGERY-SINEB H--UNTEBH'&D.4Y.
The Comparative Estimation of Estrogen Receptor Beta Expression in Primary and Metastatic Lung Cancer
Authors: T.A. Bogush, E.A. Dudko, E.A. Bogush, V.J. Kirsanov, A.N. Grishanina, R.J. Ramanauskaite, B.E. Polotsky, S. Tjulandin, M.I. Davydov
Journal: Annals of Oncology (2015)
Concentrations of the Sunscreen Agent Benzophenone-3 in Residents of the United States: National Health and Nutrition Examination Survey 2003–2004
Authors: Antonia M. Calafat, Lee-Yang Wong, Xiaoyun Ye, John A. Reidy, Larry L. Needham
Journal: Environmental Health Perspectives (2008)

The capability of benzophenone-3 (BP-3) to absorb and dissipate ultraviolet radiation facilitates its use as a sunscreen agent. BP-3 has other uses in many consumer products (e.g., as fragrance and flavor enhancer, photoinitiator, ultraviolet curing agent, polymerization inhibitor).
The Logic of Laboratory Medicine: Principles for Use of the Clinical Laboratory
Authors: Stebbins Chandor
Journal: JAMA (1986)

The subtitle "Principles for Use of the Clinical Laboratory" is probably more accurate but less catchy than the title. This text has several contributors, all individuals with experience in the clinical laboratory field. The text has four major sections: "Analytic Principles," "Advanced Analytical Principles," "Physiologic Principles," and "Selected Aspects of Laboratory Practice." At the end of each of the chapters in the first three sections are questions or problems, with the answers provided in the back of the text. Also at the back is a glossary and a usable index. The first three parts, which contain 13 chapters, generally read well and are relevant to the title and the concept that the author puts forth in his preface, ie, that clinical reasoning is absent from the curricula of most medical schools. In fact, most people would probably believe that this absence persists throughout residency and practice. The problem is how
The Duration of Life After Fatal Injuries.
Authors: H. D'Arcy Power
Journal: JAMA (1904)

San Francisco, Feb. 20, 1904. <h3>To the Editor:</h3> —The question as to how long a patient may live after the reception of necessarily fatal injuries is just now the subject of judicial inquiry in the noted Fair case. In this particular trial the point at issue is whether Charles Fair or his wife lived the longer after receiving the severe injuries to the head that were disclosed by the autopsy. So far as gross lesions are concerned it would appear that Mrs. Fair's injuries were the more severe, the frontal bone being crushed and brain tissue lost. On this ground one of the medical witnesses very confidently asserted that Mrs. Fair must have died first. Apart from the fact that vital resistance is an unknown quantity in any given case, and that some individuals, such as those possessed of the so-called status lymphaticus, may instantly die as the result of
Injection of monteplasé prior to percutaneous coronary intervention maintains left ventricular function and prevents left ventricular remodeling in acute myocardial infarction combining monteplase with angioplasty: COMA trial
Authors: Isao Yaguchi, Teruo Inoue, Ryoichi Nishiki, Junichiro Watanabe, Kei Takizawa, Yoshihiko Sakai, Kan Takayanagi, Shigenori Morooka
Journal: Journal of the American College of Cardiology (2003)
Acute Hyperglycemia Attenuates Endothelium-Dependent Vasodilation in Humans In Vivo
Authors: Stephen B. Williams, Allison B. Goldfine, Farris K. Timimi, Henry H. Ting, Mary-Anne Roddy, Donald C. Simonson, Mark A. Creager
Journal: Circulation (1998)

Background —Endothelial function is impaired in patients with diabetes mellitus. However, the factors contributing to this defect are currently unknown. Hyperglycemia attenuates endothelium-dependent relaxation in normal rabbit arteries in vitro and rat arterioles in vivo. Accordingly, this study examined the effect of acute hyperglycemia on endothelium-dependent vasodilation in nondiabetic humans in vivo. Methods and Results —Endothelium-dependent vasodilation was assessed through brachial artery infusion of methacholine chloride both before and during 6 hours of local hyperglycemia (300 mg/dL) achieved by intra-arterial infusion of 50% dextrose. Forearm blood flow was determined by plethysmography. In a group of 10 subjects, there was a trend toward attenuated methacholine-mediated vasodilation during hyperglycemia compared with euglycemia ( P =.07 by ANOVA; maximal response, 13.3±2.8 versus 14.7±1.5 mL · min −1 · 100 mL −1 , respectively). In these subjects, the systemic serum insulin levels increased significantly during the dextrose infusion ( P &lt;.001). To eliminate the confounding vasoactive effects of insulin, the protocol was repeated during systemic infusion of octreotide (30 ng · kg −1 · min −1 ) to inhibit pancreatic secretion of insulin. In these subjects (n=10), hyperglycemia significantly attenuated the forearm blood flow response to methacholine ( P &lt;.01 by ANOVA; maximal response, 16.9±2.5 before versus 12.7±1.8 mL · min −1 · 100 mL −1 during hyperglycemia). Methacholine-mediated vasodilation was not attenuated by an equimolar infusion of mannitol ( P &gt;.40), nor did hyperglycemia reduce endothelium-independent vasodilation to verapamil ( P &gt;.50). Conclusions —Acute hyperglycemia impairs endothelium-dependent vasodilation in healthy humans in vivo. This finding suggests that elevated glucose may contribute to the endothelial dysfunction observed in patients with diabetes mellitus.
Smoking Prevalence and Attitudes Toward Smoking Among Japanese Physicians
Authors: Takashi Ohida
Journal: JAMA (2001)

ContextThe World Health Organization has advocated that physicians should not smoke cigarettes and surveys on this issue should be conducted among medical professionals. However, no nationally representative surveys of smoking among physicians in Japan have been reported.ObjectivesTo estimate the nationwide prevalence of smoking and determine the attitudes toward smoking among Japanese physicians.Design, Setting, and ParticipantsDescriptive study in which anonymous questionnaires were mailed to 4500 randomly selected physician members of the Japan Medical Association in the year 2000, which represents 63% of all Japanese physicians; 3771 (84%) respondents were included in the analysis.Main Outcome MeasuresSmoking prevalence among physicians, history of smoking, and attitudes toward smoking.ResultsThe prevalence of cigarette smoking among physicians was 27.1% for men and 6.8% for women, about half the age-adjusted prevalences among the general Japanese population. Smoking prevalence was higher among male physicians in Japan than those in the United States (3%-10%) and the United Kingdom (4%-5%). Smoking prevalence differed by age, with the highest prevalence among male past smokers aged 70 years or older (51.8%; 95% confidence interval [CI], 47.4%-56.2%). Among male current smokers, the highest rates were for those aged 40 to 49 years (31%; 95% CI, 27.5%-34.5%); rates for female past smokers were highest among those aged 50 to 59 years (10.7%; 95% CI, 6.6%-14.8%) and for female current smokers were highest among those aged 70 years or older (8.2%; 95% CI, 4.8%-11.6%). Nonsmoking physicians had more unfavorable views toward smoking and were more active in encouraging patients not to smoke than those physicians who smoked.ConclusionSmoking cessation programs should be introduced among Japanese physicians to reduce the number of smoking physicians. Also, a continuing education program should be instituted to motivate physicians about their role in society.
The role of complex carbohydrates in adhesion of the myelin protein, P0
Authors: Marie T. Filbin, Gihan I. Tennekoont
Journal: Neuron (1991)

The most abundant protein of peripheral nerve myelin, a glycoprotein termed P0, is believed to be involved in the compaction of the myelin sheath and is postulated to be the closest relative to the ancestral gene for the immunoglobulin superfamily. Recently, P0 has indeed been shown to behave like a homophilic adhesion molecule via interactions of its extracellular domains. Here we demonstrate the importance of the oligosaccharide moieties of P0 in its functioning as a homophilic adhesion molecule. Expression of the complex form of P0 glycoprotein in transfected Chinese hamster ovary cells greatly increased the adhesiveness of those cells, whereas expression of the high-mannose form of P0 glycoprotein did not. This is the first step in the dissection of P0-P0 interaction at the molecular level.
IMPACT OF SHORT DURATION COLCHICINE USE ON REDUCTION OF IMMEDIATE ATRIAL FIBRILLATION AFTER CATHETER ABLATION: PROSPECTIVE STUDY
Authors: Yasuyuki Egami, Masami Nishino, Taishi Kato, Ayano Ishiyama, Hiroyuki Onishi, Naotaka Okamoto, Akihiro Tanaka, Naoki Mori, Daisuke Nakamura, Yasuharu Lee, Takahiro Yoshimura, Masayuki Taniike, Nobuhiko Makino, Hiroyasu Kato, Ryu Shutta, Hisaki Morita, Jun Tanouchi, Yoshio Yamada
Journal: Journal of the American College of Cardiology (2013)
Fas- and tumor necrosis factor receptor 1-dependent but not perforin-dependent pathways cause injury in livers infected with an adenovirus construct in mice
Authors: Zhang-Xu Liu, Sugantha Govindarajan, Shigefumi Okamoto, Gunther Dennert
Journal: Hepatology (2000)

Intravenous injection of type 5 adenovirus, deleted in the E1 and E3 regions, is shown to result in expression of viral antigens in the liver, initiating lymphocyte infiltration and liver injury. Following this infection, induction of Fas ligand (FasL), tumor necrosis factor alpha (TNF-alpha), and perforin mRNA are all demonstrable in the liver, pointing to a role of respective pathways in liver injury. Making use of mice in which the genes coding for Fas, FasL, TNF receptors (TNFRs), and perforin are inactivated, as well as recombinant proteins that inhibit Fas- and TNF-alpha-mediated apoptosis, it is shown that a functional perforin-mediated mechanism is not obligatory for cellular infiltration and progression of liver injury. In contrast functional Fas- and TNF-alpha-mediated mechanisms were found to be essential for liver injury to occur. Results are presented demonstrating that signaling through TNFR1, but not TNFR2, is involved in TNF-alpha-mediated liver damage. The conclusion is drawn that although perforin mRNA is induced in the virus-infected liver, Fas- and TNF-alpha-mediated mechanisms constitute the principal pathways by which the cell-mediated immune system causes acute liver injury.
Increased Osteoblastic Activity and Expression of Receptor Activator of NF-κB Ligand in Nonuremic Nephrotic Syndrome
Authors: Michael Freundlich, Evelyn Alonzo, Ezequiel Bellorin-Font, Jose R. Weisinger
Journal: Journal of the American Society of Nephrology (2005)

Patients with nephrotic syndrome (NS), even with normal GFR, often display altered mineral homeostasis and abnormal bone histology. However, the latter, mostly osteomalacia and increased bone resorption, cannot be readily explained by the prevalent concentrations of parathyroid hormone and vitamin D metabolites. The transmembrane receptor activator of NF-kappaB ligand (RANKL) of osteoblasts is essential for osteoclast formation and differentiation. Osteoblasts activity and the expression of RANKL were tested in cultures of normal human osteoblasts with sera obtained from patients with NS and normal GFR (129 +/- 26 ml/min per 1.73 m2) during relapse and remission of their NS. Osteoblasts that were cultured in vitro with sera during relapse displayed elevated concentrations of alkaline phosphatase (AP) and increased expression of RANKL. By contrast, during remission, AP concentrations were significantly lower (P < 0.05) and RANKL expression notably attenuated or absent. AP correlated with the proteinuria (r = 0.5, P < 0.05) and was not significantly affected by the therapeutic administration of corticosteroids. Whereas parathyroid hormone levels were normal (35 +/- 21 pg/ml), the serum markers of bone formation (osteocalcin and bone-specific alkaline phosphatase) were lower during relapse compared with remission. Thus, sera from patients with NS and normal GFR stimulate the activity of osteoblasts and upregulate their expression of RANKL. These alterations, more prominent during clinically active NS, are transient and reversible upon remission. These disturbances of bone biology may play an important pathogenic role in the abnormal bone histology observed in patients with NS even before a decline in GFR occurs.
Landmark article Aug. 27, 1921. Medicolegal application of human blood grouping. By R. Ottenberg
Authors: R. Ottenberg
Journal: JAMA (1983)

Although the inheritance, according to definite mendelian principles, of group-specific substances in human blood has been known for ten years, the application of this information to medicolegal questions has not yet been made. It is my object in the present paper to present the possibilities of this practical application and to define the instances in which it can be used. The term iso-agglutination describes the agglutination of red blood cells by contact with blood serum derived from another individual of the same species. Landsteiner, in 1901, showed that this is a normal phenomenon in all human blood, and reduced its occurrence to a definite law. With regard to the behavior of their serum and red blood cells, all human beings, without regard to race, sex or state of health, fall into one of three groups. In the first group the red cells are not agglutinable by any other human serum,
Coagulation abnormalities in the carbohydrate-deficient glycoprotein syndrome: Case report and review of the literature
Authors: Guy Young, M. Catherine Driscoll
Journal: American Journal of Hematology (1999)

The carbohydrate-deficient glycoprotein syndromes are a group of recently described autosomal recessive, metabolic defects affecting multiple systems. The disorder is caused by inefficient posttranslational glycosylation of glycoproteins. Patients with the syndrome present early in life with psychomotor retardation, seizures, hypotonia, and stroke-like episodes. They also have dysmorphic features including almond-shaped eyes, constant squint, inverted nipples, and buttock fat pads. One of the features of the syndrome is coagulopathy, and we report here a patient who presented with a prolonged activated partial thromboplastin time, and was subsequently diagnosed with the carbohydrate-deficient glycoprotein syndrome. We also summarize the results of five previously published studies of the coagulation system in these patients. Most of the reported patients are deficient in factor XI, protein C, antithrombin III, and protein S. Other coagulation proteins are less frequently affected. Both bleeding and thrombosis have been observed, yet the cause of the stroke-like episodes remains speculative. The carbohydrate-deficient glycoprotein syndrome is an increasingly recognized multisystem disorder affecting hemostasis, and thus will involve clinical hematologists as part of a multidisciplinary team caring for patients with the syndrome. Am. J. Hematol. 60:66–69, 1999. © 1999 Wiley-Liss, Inc.
Evidence for expression of early myeloid antigens in mature, non‐blast myeloid cells in myelodysplasia
Authors: Dongsheng Xu, Cynthia Schultz, Yelena Akker, Linda Cannizzaro, K.H. Ramesh, Juan Du, Howard Ratech
Journal: American Journal of Hematology (2003)

Abstract Myelodysplastic syndromes (MDS) are clonal hematopoietic stem cell disorders with frequent cytogenetic abnormalities. They can arise de novo or be related to therapy. Although blasts in MDS have been studied extensively, there is little information available on the mature, non‐blast myeloid cells (NBMCs). We used a retrospective case‐control study design. NBMC populations in MDS (48 cases) and in tumor‐free control (12 cases) bone marrow samples were analyzed using multiparameter flow cytometry for mean side scatter (SSC) channel number and for expression of aberrant cell surface antigens. MDS cases were stratified on the basis of cytogenetic abnormalities. We report that NBMCs in MDS with normal karyotype expressed significantly higher HLA‐DR than controls ( P = 0.034). NBMCs in MDS cases with cytogenetic abnormalities and with ≥5% marrow blasts, compared with controls, had significantly higher CD34 and higher HLA‐DR but lower CD10 and lower SSC mean channel number. CD34 expression in NBMCs was significantly greater in therapy‐related MDS compared with de novo MDS ( P = 0.01), although the presence of cytogenetic abnormalities was not different ( P &gt; 0.05). These data suggest that bone marrow, mature, NBMCs have phenotypic changes in MDS that are not seen in normal controls. Am. J. Hematol. 74:9–16, 2003. © 2003 Wiley‐Liss, Inc.
Abstract LB-142: Selective inhibition of BET bromodomains epigenetic signaling interferes with the bone-associated tumor vicious cycle
Authors: Francois Lamoureux, Marc Baud'Huin, Lidia Rodriguez Calleja, Camille Jacques, Francoise Redini, James E. Bradner, Dominique Heymann, Benjamin Ory
Journal: Cancer Research (2014)

Abstract Selective BET bromodomains epigenetic signaling inhibition as a therapeutic strategy in primary bone tumors The vicious cycle established between bone associated tumors and bone resorption is the central problem with therapeutic strategies against primary bone tumors and bone metastasis. The bromodomain and extra-terminal domain (BET) protein family is an important class of “histone reading protein” capable to recognize the N-acetylation of lysine residues on histone tails. BET bromain proteins have recently been described as regulators of MYC expression in various tumors. In this study, we report data to support inhibition of BET bromodomain as a novel and promising therapeutic strategy that target simultaneously the three partners of the vicious cycle. Treatment with JQ1, a unique BET bromodomain inhibitor, reduced cell viability and induced apoptosis in osteosarcoma cells and, inhibited osteoblastic differentiation in vitro. In vivo, BET inhibitor (IP; 50mg/kg) significantly inhibits tumor growth by 70% and prolongs survival in both POS-1 syngenic and MMNG/HOS xenograft models compared to control. Additionally, these results were accompanied by a decrease of associated bone lesions. These effects were associated with transcriptional silencing of MYC and RUNX2, resulting from the depletion of BRD4 from their respective loci. Moreover, JQ1 also inhibited osteoclast differentiation by interfering with BRD4-dependent RANKL activation of NFATC1 transcription. Collectively, our data indicates that JQ1 is a potent inhibitor of osteoblast and osteoclast differentiation as well as bone tumor development. Citation Format: Francois Lamoureux, Marc Baud'Huin, Lidia Rodriguez Calleja, Camille Jacques, Francoise Redini, James E. Bradner, Dominique Heymann, Benjamin Ory. Selective inhibition of BET bromodomains epigenetic signaling interferes with the bone-associated tumor vicious cycle. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr LB-142. doi:10.1158/1538-7445.AM2014-LB-142