Immunosuppressive Drugs in Rheumatoid Arthritis
Authors: JOHN BAUM
Journal: Annals of Internal Medicine (1969)

Editorials1 July 1969Immunosuppressive Drugs in Rheumatoid ArthritisJOHN BAUM, M.D., JOHN VAUGHAN, M.D.JOHN BAUM, M.D.Search for more papers by this author, JOHN VAUGHAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-71-1-202 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Excerpt"Immunosuppressive" therapy is being used more and more in the treatment of rheumatoid arthritis. Its potential role has been recognized by a committee of the American Rheumatism Association which is conducting a well-controlled multiclinic study of cyclophosphamide in this disease. The immunosuppressive drugs that have been used in the treatment of rheumatoid arthritis are nitrogen mustard (1-3), azathioprine (4-9), 6-mercaptopurine (9-11), chlorambucil (12-14), cyclophosphamide (15), and methotrexate (16).Recently, Mason and his colleagues (4) of the London Hospital published a preliminary communication on a double-blind study of azathioprine in "severe cases" of rheumatoid arthritis with long-term steroid therapy. The study...References1. JIMÉNEZ DIÁZ C: Treatment of dysreaction diseases with nitrogen mustards. Ann. Rheum. Dis. 10: 144, 1951. CrossrefMedlineGoogle Scholar2. PAULHODGESBEANROUTHDAUM WDREWBJIK: Effects of nitrogen mustard therapy in patients with rheumatoid arthritis. Arch. Phys. Med. 35: 371, 1954. MedlineGoogle Scholar3. SCHERBEL AL: Intravenous administration of nitrogen mustard alone and with corticotropin for rheumatoid arthritis. Cleveland Clin. Quart. 24: 71, 1957. CrossrefGoogle Scholar4. MASONCURREYBARNESDUNNEHAZLEMANSTRICKLAND MHLCGJFBLID: Azathioprine in rheumatoid arthritis. Brit. Med. J. 1: 420, 1969. CrossrefMedlineGoogle Scholar5. STOEBERKOLLEGRANER EGHP: [Immunosuppressive therapy in children.] (Ger.) Munchen Med. Wschr. 109: 1892, 1967. MedlineGoogle Scholar6. PHILIPSBERGENROTHERMICH VKWNO: Azathioprine therapy in 25 patients with rheumatoid arthritis (abstract). Arthritis Rheum. 10: 305, 1967. Google Scholar7. BROCTEURMOENS JC: Treatment of rheumatoid arthritis with immunosuppressive drugs. II. Immunological study. Acta Rheum. Scand. 11: 221, 1965. CrossrefMedlineGoogle Scholar8. MOENSBROCTEUR CJ: Treatment of rheumatoid arthritis with immunosuppressive drugs. I. Clinical study. Ibid., p. 212. Google Scholar9. LORENZENVIDEBAEK IA: Treatment of collagen diseases with cytostatics. Lancet 2: 558, 1965. CrossrefMedlineGoogle Scholar10. DECKERPEARSALLPILLOWLUCASTESLUK JLHRRPJEH: An approach to the treatment of malignant rheumatoid arthritis (abstract). Acta X Congr. Int. Rheum. 2: 1336, 1961. Google Scholar11. MYLES AB: 6 Mercaptopurine (6-MP) in the treatment of rheumatoid arthritis and related conditions (abstract). Ann. Rheum. Dis. 24: 179, 1965. Google Scholar12. RENIERDESHAYESBESSONBARAZERDELAHAYEBREGEON JPJCDC: [Treatment of rheumatoid arthritis with chlorambucil with reference to 48 cases.] (Fr.) Presse Med. 75: 2527, 1967. MedlineGoogle Scholar13. SÉZEDE BEDOISEAUDEBEYREKAHN SMNM: [Results of immunodepressive therapy in forty patients with severe rheumatoid polyarthritis.] (Fr.) Sem. Hôp. Paris. 43: 3084, 1967. MedlineGoogle Scholar14. KAHN M: [Immunodepressants in rheumatic diseases.] (Fr.) Presse. Med. 75: 1181, 1967. MedlineGoogle Scholar15. FOSDICKPARSONSHILL WMJLDF: Long-term cyclophosphamide therapy in rheumatoid arthritis. Arthritis Rheum. 11: 151, 1968. CrossrefMedlineGoogle Scholar16. GROSSENDERLINFEHR DMK: [The immunosuppressive treatment of progressive chronic polyarthritis with antimetabolites and cytostatics.] (Ger.) Schweiz. Med. Wschr. 97: 1301, 1967. MedlineGoogle Scholar17. BAUMHURDZIFFLEWISFERGUSON JEMDD: Treatment of psoriatic arthropathy with 6-mercaptopurine. In preparation. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOHN BAUM, M.D.; JOHN VAUGHAN, M.D.Affiliations: The University of Rochester School of Medicine and Dentistry Rochester, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byFighting rheumatoid arthritis: Kv1.3 as a therapeutic targetClinical Utility of Immunosuppressive AgentsAcute leukemia complicating metastatic breast cancerPhilip Ellman LectureThe use of chemotherapeutic agents in the treatment of non-neoplastic diseasesCytotoxic Drugs in Rheumatoid ArthritisNineteenth rheumatism review. Part-IIIRecent Advances in Rheumatic Diseases: 1967 Through 1969RICHARD H. FERGUSON, M.D., F.A.C.P., JOHN W. WORTHINGTON, M.D., F.A.C.P. 1 July 1969Volume 71, Issue 1Page: 202-204KeywordsCyclophosphamideDrug therapyDrugsImmunosuppressivesMethotrexateRheumatoid arthritisSteroid therapy ePublished: 1 December 2008 Issue Published: 1 July 1969 PDF downloadLoading ...