tbuckley/cabot-search huggingface dataset:
Prospective Assessment of <i>XPD</i> Lys751Gln and <i>XRCC1</i> Arg399Gln Single Nucleotide Polymorphisms in Lung Cancer
Authors: Daniela F. Giachino, Paolo Ghio, Silvia Regazzoni, Giorgia Mandrile, Silvia Novello, Giovanni Selvaggi, Dario Gregori, Mario DeMarchi, Giorgio V. Scagliotti
Journal: Clinical Cancer Research (2007)

Abstract Purpose: XRCC1 and XPD play key roles in the repair of DNA lesions and adducts. Contrasting findings have been reported on the effect of polymorphisms of these genes on the response to platinum-based chemotherapy in advanced non–small-cell lung cancer (NSCLC). This study aimed to investigate the relationship between the XPD Lys751Gln and XRCC1 Arg399Gln genotypes and outcome in lung cancer patients. Experimental Design: We genotyped 203 NSCLC and 45 small-cell lung carcinoma (SCLC) patients for the two polymorphisms. Most of the patients (81%) received a platinum-based chemotherapy. Results: The patients' genotype frequencies did not significantly differ from controls and both groups were in Hardy-Weinberg equilibrium for the two polymorphisms. The XRCC1399 Gln/Gln variant genotype was associated with a higher median survival time (80 weeks versus 54.6 weeks for the Arg/Gln heterozygous and 55.6 weeks for the wild-type Arg/Arg genotype; P = 0.09). At the multivariable analysis adjusted for histology, stage of the disease, performance status, age, and gender, the Gln/Gln genotype was associated with a better survival of borderline significance in the subgroup of patients treated with cisplatin (hazard ratio, 0.55; 95% CI, 0.30-1.00); this association became significant for those with grade 3-4 clinical toxicity (hazard ratio, 0.46; 95% CI, 0.22-0.98). No association between XPD Lys751Gln genotype and clinical outcome was found. Conclusion: This prospective investigation provides suggestive evidence of a favorable effect of the XRCC1399 Gln/Gln genotype on survival in platinum-treated NSCLC and, for the first time, in SCLC patients also. This contrasts with other authors who did not include non–platinum-treated patients, but it does fit the expectation for a suboptimal ability to remove DNA adducts.
Liver iron accumulation in patients with chronic active hepatitis C: prevalence and role of hemochromatosis gene mutations and relationship with hepatic histological lesions
Authors: Christophe Hézode, Cécile Cazeneuve, Oliver Coué, Francçoise Roudot-Thoraval, Isabelle Lonjon, Anne Bastie, Christophe Duvoux, Jean-Michel Pawlotsky, Elie-Serge Zafrani, Serge Amselem, Daniel Dhumeaux
Journal: Journal of Hepatology (1999)
EARLIER DIAGNOSIS OF SUBACUTE STREPTOCOCCUS VIRIDANS ENDOCARDITIS
Authors: HENRY A. CHRISTIAN
Journal: JAMA (1941)

Of 150 consecutive adult patients with subacute Streptococcus viridans endocarditis coming to the medical service of the Peter Bent Brigham Hospital in the period March 31, 1913 to Aug. 31, 1939 the majority arrived at the hospital without a correct diagnosis, or the correct diagnosis had been made by a consultant only shortly prior to hospital admission. It was unusual for the correct diagnosis to have been made by the general practitioner in charge of the patient during an illness which already had lasted for several to many weeks. From a study of the records of 150 patients it would seem that relatively few general practitioners are aware of the usual early clinical picture of bacterial endocarditis caused by Str. viridans; their unawareness leads them to fail to suspect the presence of this disease at a time when the correct diagnosis should have been quite obvious, certainly obvious enough to
Lymphocyte Subpopulations in Patients with Allergic Rhinitis
Authors: J. Kus, K. S. Tse, D. Enarson, S. Grzybowski, M. Chan‐Yeung
Journal: Allergy (1984)

The lymphocyte subpopulations were classified using monoclonal antibodies specific for B lymphocytes (B1 antibodies), T lymphocytes (T11 and OKT3 antibodies). Helper/inducer T cells (T4 antibodies) and suppressor/cytotoxic T cells (T8 antibodies). Three groups of subjects were studied: 20 normal controls, 29 patients with allergic rhinitis and a subgroup of nine patients who had received immunotherapy. The proportion of B Lymphocytes, total T cells and T4 positive (helper/inducer) cells were not significantly different between the groups, but allergic patients were found to have a decreased proportion of suppressor T8 positive (suppressor/cytotoxic) cells and hence a high helper/suppressor cell ratio. These received immunotherapy. These results imply that a suppressor cell deficiency may be an underlying mechanism of allergic disease, and that immunotherapy could correct the suppressor cell deficiency.
President of the 9th International Congress of Psychotherapy
Authors: Gordon Johnsen
Journal: Psychotherapy and Psychosomatics (1974)

Meeting Reports/Abstracts| February 12 2010 President of the 9th International Congress of Psychotherapy Subject Area: Psychiatry and Psychology Gordon Johnsen Gordon Johnsen Vikersund Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1974) 24 (4-6): 199–200. https://doi.org/10.1159/000286733 Article history Published Online: February 12 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Gordon Johnsen; President of the 9th International Congress of Psychotherapy. Psychother Psychosom 31 December 1974; 24 (4-6): 199–200. https://doi.org/10.1159/000286733 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1974Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Long-Term Glycemic Control Has a Nonlinear Association to the Frequency of Background Retinopathy in Adolescents With Diabetes: Follow-up of the Berlin Retinopathy Study
Authors: Thomas Danne, Bruno Weber, Reinhard Hartmann, Ingo Enders, Walter Burger, Gerd Hovener
Journal: Diabetes Care (1994)

OBJECTIVE To assess the influence of long-term glycemic control on the development of background retinopathy in adolescents followed longitudinally from the onset of insulin-dependent diabetes mellitus (IDDM). RESEARCH DESIGN AND METHODS Repeated retinal fluorescein angiographies, in intervals of 1–2 years, were evaluated prospectively in 346 patients (190 males, 156 females; 19.8 [8.8–35.4] years of age; diabetes duration of 10.4 [1.1–27.4] years at their latest eye examination, median [range]). The influences of long-term HbA1c (mean of 18 [1–95] determinations per person) and microalbuminuria (≥2 of ≥3 measurements ≥ 15 μg/min × 1.73 m2) were studied by multiple linear regression, life-table analysis, and trend analyses. RESULTS The rate of background retinopathy per 100 patient-years increased with poorer glycemic control from 0.7 (long-term HbA1c &amp;lt; 7% to 7.3 (HbA1c &amp;gt; 11%) following an exponential function. Life-table analysis after subdivision in HbA1c quartiles of equal sizes (HbA1c &amp;lt; 8, 8–9, 9–10, and &amp;gt; 10%) revealed an individual median expectation of background retinopathy after more than 25, 16.2, 12.7, or 12.0 years of diabetes, respectively. However, significant differences were found only between 8–9% and 9–10%, calculated either as prevalence, life-table analysis, or relative incidence, thus suggesting that a threshold model may also fit the data. After 12 years of diabetes, &amp;lt; 25% of those patients exhibiting microalbuminuria (n = 18) were expected to be free from retinopathy compared with 81% of those with normoalbuminuria (n = 86). CONCLUSIONS Two statistical models are appropriate to explain the relationship between glycemic control and risk for background retinopathy: 1) a continuous exponential relationship as described by the DCCT or 2) the presence of a threshold HbA1c level at 9%. Thus, diabetes treatment in children should aim at long-term HbA1c levels &amp;lt; 9.0%, but every progress closer to normal may further reduce the risk.
Practical study of qualitative and quantitative sebum excretion on the human forehead
Authors: D. SAINT-LEGER, E. COHEN
Journal: British Journal of Dermatology (1985)

Measurement of Sebum Excretion Rate (SER) in patients is a time-consuming test. It is now possible to measure SER 1 h after having degreased the forehead with a 70% ethanol solution. The skin surface lipids (SSL) collected during this time have similar composition to those collected for up to 7 h. A qualitative and quantitative study of sebaceous excretion, on 18 volunteers, from 1 to 7 h after having cleansed the forehead, showed that the refatting kinetics, in all subjects, obeyed the same mathematical law, independent of the subjects' individual SER.
1316 MYCOPHENOLATE FOR AUTOIMMUNE HEPATITIS TREATMENT: PROSPECTIVE ASSESSMENT OF ITS EFFICACY AND SAFETY FOR INDUCTION AND MAINTENANCE OF REMISSION IN A LARGE COHORT OF TREATMENT-NAIVE PATIENTS
Authors: K. Zachou, N. Gatselis, G. Papadamou, E.I. Rigopoulou, G.N. Dalekos
Journal: Journal of Hepatology (2011)
Women lose legal battle over radiotherapy
Authors: C. Dyer
Journal: BMJ (1998)

Two women left with useless and painful arms from the radiotherapy that they were given for breast cancer 18 years ago lost their claims for damages in the High Court in London last week.

The cases of Ethel Robb, aged 78, of Chingford, Essex, and Susan Unitt, 51, of Guernsey, are the first of what started as a large group action to end in a court judgment. The women claimed they developed brachial plexus neuropathy as a result of radiotherapy after breast …
Dysplastic naevus vs. in situ melanoma: digital dermoscopy analysis
Authors: M. Burroni, P. Sbano, G. Cevenini, M. Risulo, G. Dell'Eva, P. Barbini, C. Miracco, M. Fimiani, L. Andreassi, P. Rubegni
Journal: British Journal of Dermatology (2005)

To date, much confusion exists about the biological significance of dysplastic naevi and about the relationship between melanocytic dysplasia and clinical atypia.To use a digital dermoscopy analyser with a series of 'borderline' pigmented skin lesions (i.e. dysplastic naevi and in situ melanomas) to find correlation between the studied variables and to determine their discriminating power with respect to histological diagnosis.The pigmented skin lesions (n = 174) were histologically examined by three experienced dermatopathologists and identified as in situ melanomas (n = 38) and dysplastic naevi (n = 136). The system evaluated 48 parameters as possible discriminant variables, grouped into four categories: geometry, colours, textures and islands of colour. Once the lesions were analysed (stepwise discriminant analysis), sensitivity, specificity and accuracy were calculated.At the end of the stepwise procedure the percentage of cases classified correctly was 71.8%. Of 136 dysplastic naevi only 98 were classified correctly, while 27 of 38 in situ melanomas were recognized correctly.We conclude that there are so far no digital dermoscopic criteria that can clearly distinguish dysplastic naevi from in situ melanomas.
US accreditor moves to tackle industry's influence on medical education
Authors: Anne Harding
Journal: BMJ (2004)

The United States's chief accreditation body for medical education has announced new standards that require education providers to identify and resolve any conflicts of interest.

The Accreditation Council for Continuing Medical Education's new standards are tougher than their 1992 predecessors, which only required conflicts of interest to be disclosed. But they are less restrictive than an early draft, which unleashed a firestorm of controversy when many interpreted it as banning anyone receiving drug industry money from providing continuing medical education.

The original draft, released in January 2003, stated that if a person had conflicts of interest …
Is general practice being consigned to history?
Authors: F. Akerman
Journal: BMJ (2000)

Coming towards the final phase of a career in general practice I had hardly expected the ghost of Margot Jefferys to return to haunt me. Jefferys was a distinguished professor of sociology at London University and lectured at the Diploma of Public Health courses at the London School of Hygiene and Tropical Medicine in the 1960s.

> Something very relevant and still very special is being destroyed 

She was a good and thought provoking lecturer, but I have never forgiven her for the derisory mark given for an essay she had set with the approximate title, “Targeting of health care—universal or personal provision.” The DPH, then about to be replaced by an MSc in health care, was a marvellous course for any budding general practitioner, but by the end of it I was convinced, despite the best efforts of Professor Jefferys, that one of the principal roles of a general practitioner was to try to harness and coordinate all the appropriate strands of support for …
Aspirin does not prevent cancer, and vitamin E does not prevent heart disease or cancer
Authors: Susan Mayor
Journal: BMJ (2005)

Low dose aspirin has no effect in preventing cancer, a long term study involving nearly 40 000 healthy women has found. It also shows that vitamin E does not reduce the risk of cancer or cardiovascular disease.

The women's health study evaluated the effects of low doses of aspirin (100 mg every other day) and vitamin E (600 IU every other day) on the primary prevention of cardiovascular disease and cancer in 39 876 healthy female healthcare professionals in the United States who were followed up for an average of 10.1 years ( JAMA 2005;294:47-55). The women were aged at least 45 years at baseline and had no previous history of cancer, cardiovascular disease, or other major chronic illness.

The results showed no effect of aspirin …
Nongonococcal Urethritis in Males
Authors: Harvey E. Merlin, B. G. Clarke
Journal: New England Journal of Medicine (1956)

DURING the period from May, 1954, to January, 1956, tetracycline§ has been available for clinical trial in the Genitourinary Clinic of the Boston Dispensary. Fifty patients with nongonococcal urethritis have been treated and returned for observation. Results have been good enough to warrant continued trials of the drug and presentation of the experience thus far obtained.Material and MethodsAll 50 patients were men with urethral discharge whose smears and cultures for gonococcus were negative. Serologic reactions for syphilis were negative in each case, as were urinalyses with the exception of findings of microscopic pyuria in the majority of cases . . .
HEAVY METALS IN SYPHILIS
Authors: Franklin P. Pyles
Journal: JAMA (1934)

<h3>To the Editor:—</h3> The article "Standard Treatment Procedure in Early Syphilis," by John H. Stokes and others (The Journal, April 21), seems somewhat ambiguous on the question of treatment with heavy metals. On page 1271 the statement is made that "from the data thus presented it appears, then that the modern treatment of early syphilis should be continuous;... and in accordance with the principles generally recognized in the treatment with heavy metal for one year after all symptoms and signs of the disease have disappeared." The authors can scarcely mean that this would imply; viz., that heavy metal is given for a full year without interruption. Moreover, this is not in accordance with the scheme published on the same page. Perhaps one of the authors would be willing to clarify this.
Predicting expenditures for Medicare beneficiaries with diabetes. A prospective cohort study from 1994 to 1996.
Authors: J S Krop, C D Saudek, W E Weller, N R Powe, T Shaffer, G F Anderson
Journal: Diabetes Care (1999)

To describe health care expenditures and utilization patterns among older adults with diabetes and to examine factors associated with expenditures over a 3-year period.We conducted a prospective cohort study of health care expenditures and utilization by diabetic patients from a random nationwide sample of aged Medicare beneficiaries from 1994 to 1996. All services covered by the Medicare program were examined. Multivariate regression was used to assess the contribution of patient characteristics in 1994 on Part B, inpatient, and total expenditures in 1995 and 1996.Per capita expenditures for beneficiaries with diabetes (n = 169,613) were 1.7 times greater than those for those beneficiaries without diabetes (n = 968,832) in 1994. This ratio remained fairly constant over the 2 years of follow-up. Expenditures for beneficiaries with diabetes were highly skewed. However, few of these individuals remained in the highest expenditure quintile over the 2 years of follow-up. Using multiple regression analysis to adjust for demographic and clinical characteristics, we were able to explain 7% of the variation in total expenditures in 1995 and 6% of the variation in 1996. Using the same model, we were able to explain 10.7% of the variation in Part B expenditures in 1995 and 8% in 1996.Beneficiaries with diabetes are consistently more expensive than beneficiaries without diabetes. Demographic and clinical factors at baseline are able to predict only a small portion of future expenditures among this population, and the most expensive patients in one year were often not the most expensive in subsequent years. More work is necessary to assure equitable risk adjustment in the calculation of capitation rates for health plans and practitioners who specialize in the care of individuals with diabetes.
A book that changed my practice: New insights into mental illness
Authors: E J Ben-Eliezer
Journal: BMJ (2000)

It had all become depressingly familiar: the suicidal teenager with relationship difficulties; a middle-aged office worker who had lost the energy to keep going; a lonely pensioner with insomnia and multiple functional complaints. The answer to all of these and many more was: start an antidepressant, take a few moments to hear their complaints, refer for some counselling. And yet many times nothing really helped. Despite the much vaunted hype and advertising of antidepressants, most GPs will know how little they can do for the patients we see …
Reversibility of Catecholamine-Induced Dilated Cardiomyopathy in a Child with a Pheochromocytoma
Authors: Julianne Imperato-McGinley, Teofilo Gautier, Kathryn Ehlers, Michael A. Zullo, David S. Goldstein, E. Darracott Vaughan
Journal: New England Journal of Medicine (1987)

PATIENTS with a severe, dilated cardiomyopathy with congestive heart failure have a poor prognosis unless a correctable cause can be identified. Even when a cause is found, the degree of reversibility of myocardial injury is uncertain.1 We describe a 12-year-old child with a pheochromocytoma who had a dilated cardiomyopathy and congestive heart failure due to excessive production of catecholamines by the tumor. Because her poor clinical state made surgery too hazardous, she was treated for seven months with the a-adrenergic-receptor antagonist phenoxybenzamine and the tyrosine hydroxylase inhibitor α-methylpara-tyrosine (MPT) to decrease her plasma catecholamine levels. With increasing doses of MPT, . . .
Attracting patients to dentists.
Authors: S. Lindsay, J. Woolgrove
Journal: BMJ (1989)

exist in the prevalence of dental caries almost certainly arise because the rules are better understood and more widely followed in affluent communities.Attempts to improve further the dental health of children must take account of these socially determined differences.Water fluoridation must remain the cornerstone of policy because it benefits all consumers regardless of social con- straints on health behaviour.The past decade has been important in the history of water fluoridation in Britain.In 1978 an individual citizen applied for an interdict to restrain the Strathclyde Regional Council from fluoridating its water supplies.There followed the longest case in British legal history, after which the judge, Lord Jauncey, fully endorsed the effectivenesss and safety of water fluoridation but questioned its legality.This prompted the government to introduce a bill, and after extensive parliamentary debate the Water (Fluoridation) Act was passed in 1985.This act requires health authorities to consult widely before requesting their water suppliers to fluoridate.In some parts of the country-notably, the Trent, North Western, and Mersey regions -this consultation process is complete or well under way.Extensive support for fluoridation has come from the dental, medical, and allied professions, and the prospects are good for implementing several new major fluoridation schemes that will further improve the dental health of children, particularly among the groups in which it is still unacceptably poor.
Autopsy and Diagnosing SIDS
Authors: Millard Bass
Journal: JAMA (1989)

To the Editor. —  Allen et al 1 make one assumption concerning postneonatal sudden infant death with which I do not agree. They assume that sudden infant death syndrome (SIDS) can be verified by autopsy. However, SIDS is an exclusionary diagnosis that requires careful death-scene investigation. 2 There are no shortcuts; the investigation should include an on-site environmental assessment. Unfortunately, the authors did not collect detailed deathscene information on the circumstances surrounding death in the SIDS cases. The source of the SIDS diagnosis in their small study was frequently death certificate data. 3   The Georgia Post-Mortem Examination Act allows medical examiners to perform autopsies and conduct deathscene investigations on infants who die presumptively of SIDS. It is surprising that, with the great advances in neonatal survival in Georgia and with the tremendous cost in the intensive care of critically ill newborns, nearly half of the infants in this study who
Reflex Sympathetic Dystrophy and Pancoast Tumor
Authors: W L. Bertrand Ang, Yvonne Y. Ho
Journal: Clinical Nuclear Medicine (2004)

A 52-year-old retired gardener presented with a history of right upper extremity pain for 3 months. A chest radiograph confirmed the presence of a mass in the right lung apex. This was proven to be a nonsmall cell lung carcinoma at bronchoscopy. A staging bone scan was performed, which showed increased osteoblastic activity in a periarticular distribution in the right upper extremity, right first rib, right clavicle, and right acromion. This appearance confirmed the diagnosis of reflex sympathetic dystrophy. This case highlights the importance of a bone scan in the diagnosis of reflex sympathetic dystrophy.