Calcium-Channel Blocking Agents and Asthma
Authors: E.R. MCFADDEN
Journal: Annals of Internal Medicine (1981)

Editorials1 August 1981Calcium-Channel Blocking Agents and AsthmaE.R. MCFADDEN JR, M.D.E.R. MCFADDEN JR, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-95-2-232 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptBronchial asthma is a common disorder that has been reported to affect from 2. 5% to 3% of the population of the United States. Although it is a disease with low mortality, the morbidity is immense. On a yearly basis, acute episodes of asthma have been estimated to account for 40 000 hospital admissions, 27 million physicians visits, and 90 million days of absence from work and school (1). In an effort to minimize the impact of this illness, there has been a continual search for more effective forms of treatment. As a result, in recent years, our understanding of...References1. . Asthma and the other allergic diseases. Washington, D.C.: U. S. Government Printing Office; 1979; 1-20. (NIH Publication no. 79-387). Google Scholar2. SVEDMYRSIMONSSON NB. Drugs in the treatment of asthma. Pharm TherB. 1978;3:397-440. Google Scholar3. SAUNDERSMCFADDEN NE. Asthma—an update. DM. 1978;24(11):1-49. MedlineGoogle Scholar4. MIDDLETON E. Antiasthmatic drug therapy and calcium ions. Review of pathogenesis and role of calcium. J Pharm. Sci. 1980;69:243-51. CrossrefMedlineGoogle Scholar5. COBURN R. The airway smooth muscle cell. Fed Proc. 1977;36:2692-7. MedlineGoogle Scholar6. STONEANTMANMULLERBRAUNWALD PEJE. Calcium channel blocking agents in the treatment of cardiovascular disorders. Part II. Hemodynamic effects and clinical applications. Ann Intern Med. 1980;93:886-904. LinkGoogle Scholar7. JAIPRAKASHSAHAYCHATTERJEEMACDONALD SJSG. Efficacy of nifedipine in the treatment of angina pectoris and chronic airways obstruction. Postgrad Med J. 1980;56:624-8. CrossrefMedlineGoogle Scholar8. HILLS E. Iproveratril and bronchial asthma. Br J Clin Pract. 1970;24:116-7. MedlineGoogle Scholar9. RINGQVIST T. Effect of verapamil in obstructive airways disease. Eur J Clin Pharmacol. 1974;7:61-4. CrossrefMedlineGoogle Scholar10. ATTERHÖG J. Verapamil vid hjartarrythmier. Opusc Med Bd. 1969;14:127-31. Google Scholar11. CERRINADENJEANGERARDLOUCHARTDUROUX JAAAP. Inhibition of exercise-induced asthma by a calcium antagonist, nifedipine. Am Rev Respir Dis. 1981;123:156-60. MedlineGoogle Scholar12. PATEL K. Calcium antagonists in exercise-induced asthma. Br Med J. 1981;282:932-3. CrossrefMedlineGoogle Scholar13. ULMSTENANDERSSONWINGERUP UKL. Treatment of premature labor with the calcium antagonist nifedipine. Arch Gynecol. 1980;229:1-5. CrossrefMedlineGoogle Scholar14. FORMANANDERSSONHENRIKSSONRUDULMSTED AKLTU. Effects of nifedipine on the smooth muscle of the human urinary tract in vitro and in vivo. Acta Pharmacol Toxicol. 1978;43:111-18. CrossrefMedlineGoogle Scholar15. WEISERLEPSIENGOLENHOTENSCHATTENMANNSIEWERT HGKGR. Klinische and unexperimentelle Untersuchungen zur Wirkung von Nifedipine auf die glatte Musculatur des Ösophagus. Z Gastroenterol. 1977;15:691-8. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Shipley Institute of Medicine Brigham and Women's Hospital Boston, Massachusetts PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByExercise-induced asthma: Update on pathophysiology, clinical diagnosis, and treatmentDiagnosis and Management of Exercise-Induced AsthmaEffect of Parenteral Magnesium Sulfate on Pulmonary Functions in Bronchial AsthmaPharmacological characterization of effects of verapamil and GS 283 on isolated guinea pig and rat trachealisLes inhibiteurs calciques013 en pédiatriePropofol induces bronchodilation in mechanically ventilated chronic obstructive pulmonary disease (COPD) patientsCardiac ArrhythmiasExercise-Induced AsthmaPharmakologische Wirkungen der Calcium-AntagonistenIndikationen für Calcium-AntagonistenCalcium Channel BlockersComparison of the effects of inhaled calcium antagonist verapamil, sodium cromoglycate and ipratropium bromide on exercise-induced bronchoconstriction in children with asthmaEffect of cinnarizine on IgE antibody-mediated experimental allergic reactions in guinea pigsDie „neuen“ Formen sozialer Ungleichheit und die Differenzierung der SozialstrukturEffect of nifedipine on arterial hypoxaemia occurring after methacholine challenge in asthma.Drug Information Analysis ServiceAgonist-induced contractile responses of human bronchial muscle in vitro: Effects of Ca2+ removal, La3+ and PY108068Comparative effects of various calcium entry blockers and anti-asthmatic compounds on antigen-induced bronchoconstriction in rat and histamine release from rat mast cellsSelection of Optimal Drug Therapy for the Patient With Angina PectorisExcitation-contraction coupling and uncoupling in airway smooth muscle.The management of status asthmaticus in infants and childrenEffect of Diltiazem on Histamine-and Carbachol-induced Bronchospasm in Normal and Asthmatic SubjectsCalcium-channel blockers in prophylaxis and treatment of asthmaAnticholinergics, Cromolyn, and Other Occasionally Useful DrugsEffects of Verapamil on Histamine and Carbachol-Induced Contraction of Pulmonary Tissues in VitroLack of effect of leukotriene D4 on Ca-uptake in airway smooth muscleEffects of calcium channel blockade on histamine induced bronchoconstriction in mild asthma.Effect of nifedipine on constriction of human tracheal strips in vitroComparison of the effects of slow Ca2+ channel blockers and other agents on passive cutaneous anaphylaxis in the ratClinics and Treatment of AsthmaCalcium, the Control of Smooth Muscle Function and Bronchial HyperreactivityTreatment of UrticariaChapter 6. Pulmonary and Antiallergy Agents 1 August 1981Volume 95, Issue 2Page: 232-233KeywordsAsthmaMorbidityMortality Issue Published: 1 August 1981 PDF DownloadLoading ...