Minocycline for the Treatment of Takayasu Arteritis
Authors: Akifumi Matsuyama, Naohiko Sakai, Masato Ishigami, Hisatoyo Hiraoka, Shizuya Yamashita
Journal: Annals of Internal Medicine (2005)

Letters6 September 2005Minocycline for the Treatment of Takayasu ArteritisAkifumi Matsuyama, MD, PhD, Naohiko Sakai, MD, PhD, Masato Ishigami, MD, PhD, Hisatoyo Hiraoka, MD, PhD, and Shizuya Yamashita, MD, PhDAkifumi Matsuyama, MD, PhDFrom Osaka University Graduate School of Medicine, Osaka 565-0871, Japan.Search for more papers by this author, Naohiko Sakai, MD, PhDFrom Osaka University Graduate School of Medicine, Osaka 565-0871, Japan.Search for more papers by this author, Masato Ishigami, MD, PhDFrom Osaka University Graduate School of Medicine, Osaka 565-0871, Japan.Search for more papers by this author, Hisatoyo Hiraoka, MD, PhDFrom Osaka University Graduate School of Medicine, Osaka 565-0871, Japan.Search for more papers by this author, and Shizuya Yamashita, MD, PhDFrom Osaka University Graduate School of Medicine, Osaka 565-0871, Japan.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-143-5-200509060-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Background: Takayasu arteritis is a type of chronic vasculitis that primarily affects large elastic arteries. It tends to progress despite treatment with glucocorticoids or immunosuppressive agents (1, 2). Recently, we reported that matrix metalloproteinases (MMPs) might contribute to the pathogenesis and exacerbation of Takayasu arteritis and that circulating levels of MMPs could be diagnostic markers of the disease (3). While many MMP inhibitors are under development (4), minocycline has established MMP inhibitor activity that is independent of antimicrobial activity (5).Objective: To assess the effect of combination treatment with minocycline and glucocorticoid for active Takayasu arteritis.Methods ...References1. Arend WP, Michel BA, Bloch DA, Hunder GG, Calabrese LH, Edworthy SM, et al. The American College of Rheumatology 1990 criteria for the classification of Takayasu arteritis. Arthritis Rheum. 1990;33:1129-34. [PMID: 1975175] CrossrefMedlineGoogle Scholar2. Kerr GS, Hallahan CW, Giordano J, Leavitt RY, Fauci AS, Rottem M, et al. Takayasu arteritis. Ann Intern Med. 1994;120:919-29. [PMID: 7909656] LinkGoogle Scholar3. Matsuyama A, Sakai N, Ishigami M, Hiraoka H, Kashine S, Hirata A, et al. Matrix metalloproteinases as novel disease markers in Takayasu arteritis. Circulation. 2003;108:1469-73. [PMID: 12952836] CrossrefMedlineGoogle Scholar4. Matter H, Schudok M. Recent advances in the design of matrix metalloprotease inhibitors. Curr Opin Drug Discov Devel. 2004;7:513-35. [PMID: 15338961] MedlineGoogle Scholar5. Cooper SM. Tetracyclines.. In: Ruddy S, Harris ED, Sledge CB, eds. Kelley's Textbook of Rheumatology. Philadelphia: WB Saunders; 2001:913-20. Google Scholar Author, Article, and Disclosure InformationAuthors: Akifumi Matsuyama, MD, PhD; Naohiko Sakai, MD, PhD; Masato Ishigami, MD, PhD; Hisatoyo Hiraoka, MD, PhD; Shizuya Yamashita, MD, PhDAffiliations: From Osaka University Graduate School of Medicine, Osaka 565-0871, Japan.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoTakayasu Arteritis Gail S. Kerr , Claire W. Hallahan , Joseph Giordano , Randi Y. Leavitt , Anthony S. Fauci , Menachem Rottem , and Gary S. Hoffman Metrics Cited byTakayasu arteritis in a patient presenting with stroke and improvement of hemiparesis following vascular bypass surgery: A case reportCerebral involvement in systemic vasculitidesTakayasu arteritisTetracyclines, Glycylcyclines, and ChloramphenicolAcknowledged Signatures of Matrix Metalloproteinases in Takayasu’s ArteritisManagement options for Takayasu arteritisExtracellular Matrix Remodeling in Takayasu's Arteritis: Role of Matrix Metalloproteinases and Adventitial InflammationTransient Ischemic Attacks in a 22-Year-OldTakayasu's arteritisCollagen Vascular and Infectious DiseasesMinocyclineTakayasu arteritis—advances in diagnosis and managementEffect of an Antimicrobial Agent on Atherosclerotic PlaquesTakayasu's ArteritisTakayasu’s disease: a reviewTakayasu’s arteritisGiant cell and Takayasu arteritisCurrent World Literature 6 September 2005Volume 143, Issue 5Page: 394-395KeywordsAntimicrobialsC-reactive proteinsHospital medicineImmunosuppressivesPathogenesisRheumatoid arthritisRheumatologySteroidsVasculitis ePublished: 6 September 2005 Issue Published: 6 September 2005 Copyright & PermissionsCopyright © 2005 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...