Sex Differences in Long-Term Mortality after Myocardial Infarction
Authors: Ernest H. Friedman
Journal: Annals of Internal Medicine (2001)

Letters18 December 2001Sex Differences in Long-Term Mortality after Myocardial InfarctionErnest H. Friedman, MDErnest H. Friedman, MDCase Western Reserve University; East Cleveland, OH 44112Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-135-12-200112180-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Vaccarino and colleagues (1) found that younger women with myocardial infarction are at greater risk for death than men. Neurobiological features are suggested by reports linking anxiety, dysregulation of brain stem cardiovascular control, coping behavior, cortical silent periods, immune function, the microvasculature, mood, rumination, and subclinical impairment of lung airways with dopamine abnormalities lateralized to the right hemisphere, for which the metabolic rate is higher in women. This hypothesis is supported by optimal response organization and working memory at intermediate dopamine tone in a mediofrontostriatal activation system, as well as deactivation of the right hemisphere, a state ...References1. Vaccarino V, Krumholz HM, Yarzebski J, Gore JM, Goldberg RJ. Sex differences in 2-year mortality after hospital discharge for myocardial infarction. Ann Intern Med. 2001;134:173-81. [PMID: 11177329] LinkGoogle Scholar2. Friedman EH. Neurobiology of short stature and prognosis of coronary heart disease in women [Letter]. J Intern Med. 2000;247:517-8. [PMID: 10792568] CrossrefMedlineGoogle Scholar3. Friedman EH. Young survivors of myocardial infarction [Letter]. Psychother Psychosom. 1997;66:329. [PMID: 9403923] CrossrefMedlineGoogle Scholar4. Ayanian JZ. Increased mortality among middle-aged women after myocardial infarction: searching for mechanisms and solutions [Editorial]. Ann Intern Med. 2001;134:239-41. [PMID: 11177337] LinkGoogle Scholar5. Friedman EH, Coats AJ. Neurobiology of exaggerated heart oscillations during two meditative techniques [Letter]. Int J Cardiol. 2000;73:199. [PMID: 10905879] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Ernest H. Friedman, MDAffiliations: Case Western Reserve University; East Cleveland, OH 44112 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoIncreased Mortality among Middle-Aged Women after Myocardial Infarction: Searching for Mechanisms and Solutions John Z. Ayanian Sex Differences in 2-Year Mortality after Hospital Discharge for Myocardial Infarction Viola Vaccarino , Harlan M. Krumholz , Jorge Yarzebski , Joel M. Gore , and Robert J. Goldberg Sex Differences in Long-Term Mortality after Myocardial Infarction Viola Vaccarino and Robert J. Goldberg Sex Differences in Long-Term Mortality after Myocardial Infarction J. Carlos Ayus and Allen I. Arieff Sex Differences in Long-Term Mortality after Myocardial Infarction Kathleen Franco-Bronson , Marijo Tamburrino , and Nicolle McGowan Metrics 18 December 2001Volume 135, Issue 12Page: 1090KeywordsAnxietyBrainDopamineFatigueLungsMortalityMyocardial infarctionStable coronary artery diseaseVasoconstrictionWorking memory ePublished: 18 December 2001 Issue Published: 18 December 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...