Cardiac Amyloidosis
Authors: JAMES T. CASSIDY
Journal: Annals of Internal Medicine (1961)

Case Reports1 December 1961Cardiac AmyloidosisTwo Cases with Digitalis SensitivityJAMES T. CASSIDY, M.D.JAMES T. CASSIDY, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-55-6-989 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptGeneralized Amyloidosis is an uncommon disorder; the approximate frequency at autopsy is 0.5%. It is, however, a subject of frequent diagnostic consideration because of its diversified clinical manifestations. The heart is affected to a significant degree in 40 to 90% of cases (1-4). Such involvement was responsible for major disability in two patients, one with primary amyloidosis, the other with amyloidosis secondary to plasmacytoma. Observations in these cases which might suggest amyloid infiltration as a cause for obscure heart disease are discussed, with particular attention to a previously unreported sensitivity to digitalis.CASE REPORTSCASE 1A 58-year-old farmer was...References1. SYMMERS WS: Primary amyloidosis: a review. J. Clin. Path. 9: 187, 1956. CrossrefMedlineGoogle Scholar2. RUKAVINABLOCKJACKSONFALLSCAREYCURTIS JGWDCEHFJHAC: Primary systemic amyloidosis: a review and an experimental, genetic, and clinical study of 29 cases with particular emphasis on the familial form. Medicine 35: 239, 1956. CrossrefMedlineGoogle Scholar3. BUERGERBRAUNSTEIN LH: Senile cardiac amyloidosis. Amer. J. Med. 28: 357, 1960. CrossrefMedlineGoogle Scholar4. DAHLIN DC: Secondary amyloidosis. Ann. Intern Med. 31: 105, 1949. LinkGoogle Scholar5. SANDERSCHILD RJCG: Primary amyloidosis with jaundice. J. A. M. A. 174: 1202, 1960. CrossrefMedlineGoogle Scholar6. 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Cassidy, M.D., Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan. 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JAMES, M.D., F.A.C.P.Digitalis-induced arrhythmias and their managementThe pathology of senile cardiac amyloidosisSenile cardiac amyloidosis.Störungen des ProteinstoffwechselsThe clinical spectrum of primary myocardial diseaseAmyloid heart diseaseClinical manifestations of cardiac amyloidosis 1 December 1961Volume 55, Issue 6Page: 989-994KeywordsAmyloidosisArrhythmiaArthritisAutopsyCardiovascular therapyDisabilitiesElectrocardiographyHeartHospital medicine Issue Published: 1 December 1961 PDF DownloadLoading ...