Ofloxacin and Warfarin
Authors: Jonathan Leor
Journal: Annals of Internal Medicine (1988)

Letters and Corrections1 November 1988Ofloxacin and WarfarinJonathan Leor, MD, Shlomo Matetzki, MDJonathan Leor, MD, Shlomo Matetzki, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-9-761_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOfloxacin, a new 4-quinolone derivative that can be administered orally, has a broad spectrum of activity against many important aerobic and anaerobic pathogens. We report a case of dangerously excessive anticoagulation in a patient given ofloxacin while she was receiving warfarin therapy.A 40-year-old woman had mitral valve replacement. After the operation, she was treated with digoxin, furosemide, spironolactone, prednisone, verapamil, and warfarin (5 mg daily). Her international normalized ratio was 2:5, and was well controlled and within the therapeutic range (2:3) for the next postoperative course.Ten days after surgery, a wound infection at the cannulation site of the...References1. Leor J, Levartowsky D, and Sharon C. Interaction between nalidixic acid and warfarin [Letter]. Ann Intern Med. 1987;107:601. LinkGoogle Scholar2. Toon S, Hopkins J, and Garstang F. Enoxacin-warfarin interaction: pharmacokinetic and stereochemical aspects. Clin Pharmacol Ther. 1987;42:33-41. CrossrefMedlineGoogle Scholar3. Lode H, Hoffken G, and Prinzing C. Comparative pharmacokinetics of new quinolones. Drugs. 1987;34(Suppl 1):21-5. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Jonathan Leor, MD; Shlomo Matetzki, MDAffiliations: Chaim Sheba Medical Center Tel Hashomer Israel Sackler School of Medicine Tel Aviv University Tel Aviv Israel PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byQuinolonesAcute renal failure caused by severe coagulopathy induced by the interaction between warfarin potassium and levofloxacin: a case reportQuinolonesOfloxacinInteraction between Warfarin and Levofloxacin: Case SeriesThe safety of levofloxacin in elderly patients on warfarinMoxifloxacin and Warfarin: Additional Evidence for a Clinically Relevant InteractionDrug Interactions Between Antibiotics and Select Maintenance Medications: Seeing More Clearly Through the Narrow Therapeutic Window of OpportunityEffect of Levofloxacin Coadministration on the International Normalized Ratios During Warfarin TherapyLevofloxacin and Warfarin InteractionClinically Significant Interactions with Drugs Used in the Treatment of TuberculosisINTERACTIONS OF WARFARINLevofloxacin and Warfarin InteractionQuinolonesClinical PharmacologyDrug Interactions with Antimicrobial AgentsAbsence of an Effect of Levofloxacin on Warfarin Pharmacokinetics and Anticoagulation in Male VolunteersEffect of ciprofloxacin on the hypoprothrombinemic activity of warfarin in ratsPharmacokinetics of Gyrase Inhibitors, Part 2: Renal and Hepatic Elimination Pathways and Drug InteractionsUrinary Tract InfectionsDrug interactions with fluoroquinolonesOverview of fluoroquinolone safetyTemafloxacin: A safe antibiotic for the elderly, patients with comorbidities, and other special populationsCiprofloxacin interaction with sodium warfarin: A potentially dangerous side effectOfloxacinPost-marketing surveillance of quinolones 1988–1990Norfloxacin Does Not Alter Warfarin's Disposition or Anticoagulant EffectCiprofloxacinPossible Interaction between Ciprofloxacin and WarfarinFluoroquinolone-drug interactions: An overviewDrug-drug interactions with ciprofloxacin and other fluoroquinolonesFluoroquinolone antimicrobial agents 1 November 1988Volume 109, Issue 9Page: 761-761KeywordsCannulationInternational normalized ratioMitral valve replacementPathogensSurgery ePublished: 1 December 2008 Issue Published: 1 November 1988 PDF downloadLoading ...