Hemolytic Uremic Syndrome in a Patient Treated with Clopidogrel
Authors: Peter H.N. Oomen, Jaap E. Tulleken, Jan G. Zijlstra
Journal: Annals of Internal Medicine (2000)

Letters20 June 2000Hemolytic Uremic Syndrome in a Patient Treated with ClopidogrelPeter H.N. Oomen, MD, Jaap E. Tulleken, MD, PhD, and Jan G. Zijlstra, MD, PhDPeter H.N. Oomen, MDUniversity Hospital Groningen; NL-9700 RB Groningen, the Netherlands (Oomen)University Hospital Groningen; NL-9700 RB Groningen, the Netherlands (Tulleken)University Hospital Groningen; NL-9700 RB Groningen, the Netherlands (Zijlstra)Search for more papers by this author, Jaap E. Tulleken, MD, PhDUniversity Hospital Groningen; NL-9700 RB Groningen, the Netherlands (Oomen)University Hospital Groningen; NL-9700 RB Groningen, the Netherlands (Tulleken)University Hospital Groningen; NL-9700 RB Groningen, the Netherlands (Zijlstra)Search for more papers by this author, and Jan G. Zijlstra, MD, PhDUniversity Hospital Groningen; NL-9700 RB Groningen, the Netherlands (Oomen)University Hospital Groningen; NL-9700 RB Groningen, the Netherlands (Tulleken)University Hospital Groningen; NL-9700 RB Groningen, the Netherlands (Zijlstra)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-12-200006200-00025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Clopidogrel and ticlopidine are thienopyridine derivatives that inhibit platelet aggregation. Ticlopidine may induce neutropenia, renal failure, and thrombotic thrombocytopenic purpura (1). Clopidogrel is associated with a lower incidence of side effects than ticlopidine is (2). We report a case of the hemolytic uremic syndrome that developed during clopidogrel therapy.A 70-year-old man presented with myocardial infarction. His medications were metoprolol, perindopril, hydrochlorothiazide, nifedipine, simvastatin, and acenocoumarol. Primary percutaneous transluminal coronary angioplasty with coronary artery stenting was performed, followed by abciximab therapy for 12 hours. Oral clopidogrel therapy (300 mg, followed by 75 mg once daily) was started. ...References1. Bennett CL, Weinberg PD, Rozenberg-Ben-Dror K, Yarnold PR, Kwaan HC, Green D. Thrombotic thrombocytopenic purpura associated with ticlopidine. A review of 60 cases. Ann Intern Med. 1998;128:541-4. LinkGoogle Scholar2. Moussa I, Oetgen M, Roubin G, Colombo A, Wang X, Iyer S, et al . Effectiveness of clopidogrel and aspirin versus ticlopidine and aspirin in preventing stent thrombosis after coronary stent implantation. Circulation. 1999;99:2364-6. CrossrefMedlineGoogle Scholar3. Zijlstra JG. Hemolytic uremic syndrome/thrombotic thrombocytopenic purpura in the ICU.. In: Vincent JL, eds. Yearbook of Intensive Care and Emergency Medicine 1999. Brussels: Springer Berlin; 1999:559-69. Google Scholar Author, Article, and Disclosure InformationAuthors: Peter H.N. Oomen, MD; Jaap E. Tulleken, MD, PhD; Jan G. Zijlstra, MD, PhDAffiliations: University Hospital Groningen; NL-9700 RB Groningen, the Netherlands (Oomen)University Hospital Groningen; NL-9700 RB Groningen, the Netherlands (Tulleken)University Hospital Groningen; NL-9700 RB Groningen, the Netherlands (Zijlstra) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMitomycin-C-Induced Thrombotic Thrombocytopenic PurpuraThrombocytopenia following Percutaneous Coronary InterventionNoncardiogenic pulmonary edema associated with clopidogrel: A serious but unexpected side effect of clopidogrelClopidogrel-Induced Thrombotic Thrombocytopenic Purpura—Hemolytic Uremic Syndrome After Coronary Artery StentingDrug-induced Thrombotic Thrombocytopenic Purpura/Hemolytic Uremic Syndrome: A Concise ReviewThe role of clopidogrel in the management of acute coronary syndromesClopidogrel-Induced Systemic Inflammatory Response SyndromeDrug-associated thrombotic thrombocytopenic purpura-hemolytic uremic syndromeClopidogrel 20 June 2000Volume 132, Issue 12Page: 1006KeywordsHemolytic-uremic syndromeKidneysRenal failureRespiratory failureSodiumSputumThrombotic thrombocytopenic purpuraUreaUrineVentilators ePublished: 15 August 2000 Issue Published: 20 June 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...