tbuckley/cabot-search huggingface dataset:
INJURIES IN WOMEN'S BEGINNER FUTSAL LEAGUE
Authors: T Kamiya, K Nakano, T Yamashita
Journal: British Journal of Sports Medicine (2014)

Background The number of women who begin to play soccer and futsal is increasing rapidly in Japan. In particularly, futsal is more popular for beginners because few players are able to enjoy themselves indoors observing such a simple rule. However, injuries concerning with women's beginner futsal have not been reported previously. Objective The aim of this study is to clear the characteristics of the injury in women's beginner futsal league. Design This study was investigated prospectively. Setting The subjects were players participated in the women's beginner futsal league. Participants A total of 465 players (38 teams) registered to women's beginner futsal league in Hokkaido (a northern region of Japan) for 2009–2010 seasons were investigated in this study. Inclusion criteria of the beginner were defined that the experience period for soccer or futsal was less than four years. Interventions This study was supported by the Hokkaido Football Association. Every team had an obligation to send the questionnaire concerning injuries after each game. This questionnaire was consisted of the injury characteristic, the part of the injury, the degree of the injury, and the how to treatment. Main outcome measurements Injury rate was analyzed by the injury number/1000 player-hours. Results The injury rate was 144.3/1000 player-hours. The most occurring injury was the ankle sprain that the injury rate was 52.6/1,000 player-hours. The incidence of the anterior cruciate ligament injury of the knee was 2.6/1000 player-hours. Conclusions The injury rate in women's futsal league was quite high compared with men and women professional soccer league. Interventions to reduce the injury should be suggested to the women who begin to play futsal.
Gastroscopic Mucosal Folding in Estimation of Gastritis and Gastric Secretion
Authors: J. Myren, A. Berstad, A. Serck-Hanssen
Journal: Endoscopy (1972)

Decreased mucosal folding was observed by gastroscopy in 75 per cent of cases with atrophic gastritis. The average acid output per hour after “maximal” stimulation was 6.7 mEq in women and 9.1 mEq in men, which were highly significantly lower than the values found in patients with normal mucosal folding, 15.7 mEq in women and 20.7 mEq in men.
Inactivation of p16INK4 in hepatocellular carcinoma
Authors: A Hui, M Sakamoto, Y Kanai, Y Ino, M Gotoh, J Yokota, S Hirohashi
Journal: Hepatology (1996)

We analyzed the p16INK4 status of 6 hepatocellular carcinoma (HCC) cell lines and 32 primary HCC tumors, including 9 early-stage tumors, to determine whether p16INK4 tumor-suppressor gene inactivation participates in hepatocarcinogenesis. p16INK4 was studied at its protein level through Western blotting, at its messenger RNA (mRNA) level through reverse-transcriptase polymerase chain reaction analysis (RT-PCR) and Northern blotting, and at its genomic level through Southern blotting and PCR-single-strand conformation polymorphism analysis. The p16 protein was absent from 3 of 6 cell lines (50%) and 11 of 32 primary tumors (34%), but present in noncancerous tissues, indicating that p16INK4 is involved in hepatocarcinogenesis. Furthermore, we suggest that the p16 protein loss may contribute to the following: (1) early-stage hepatocarcinogenesis, because it was observed in 22% of early stage tumors; and (2) tumor progression, because it occurred approximately twice as often in advanced rather than in early stage tumors (40%). It was striking that neither p16INK4 homozygous deletion and mutation nor loss of p16INK4 mRNA expression were observed in HCC cell lines and primary tumors, including those specimens from which the p16 protein was absent except the Li7HM cell line, in which p16INK4 mRNA was not detected. These results suggest that p16INK4 in HCC is inactivated predominantly by posttranscriptional regulation rather than by genomic aberrations and lack of transcription.
Including mental health among the new sustainable development goals
Authors: G. Thornicroft, V. Patel
Journal: BMJ (2014)

The case is compelling



Him too



The United Nations will soon decide what will follow its millennium development goals, which expire in 2015. The case for including mental health among the new sustainable development goals is compelling, both because it cuts across most of the suggested new goals and because of the unmet needs of the 450 million people in the world with mental illness.1

Poorer mental health is a precursor to reduced resilience to conflict. It’s also a barrier to achieving the suggested goal of promoting peaceful and inclusive societies for sustainable development, providing access to justice for all, and building effective, accountable, and inclusive institutions at all levels. In addition, conflict is itself a risk factor for adverse mental health consequences,2 and in the aftermath of conflict the needs of vulnerable groups such as people with mental illness are often accorded the lowest priority (as documented by photojournalist Robin Hammond, www.robinhammond.co.uk). 

The improvement of mental health systems will also have a decisive role in making cities and human settlements inclusive, safe, resilient, and sustainable, and this is especially important given the global trend towards urbanisation with its associated risk factors for mental illness. Moreover, individual adversity—for example, complications of pregnancy , such as miscarriage—is associated with worse mental health.

A third suggested goal is to promote sustained, inclusive, and sustainable economic growth, full and productive employment, and decent …
Response to Letter Regarding Article, “Reduction in the Incidence of Acute Myocardial Infarction Associated With a Citywide Smoking Ordinance”
Authors: Carl Bartecchi, Mori J. Krantz, Becki Bucher Bartelson, Raymond O. Estacio, Robert N. Alsever, Christine Nevin-Woods, William M. Thomas
Journal: Circulation (2007)

Associated With a Citywide Smoking Ordinance"We agree with Dr Vogt that a before-after observational study design cannot clearly establish a relationship between a smoking ordinance and a reduction in acute myocardial infarction (AMI), as we acknowledged. 1The intrinsic limitations of observational data notwithstanding, multiple confirmatory studies suggest our findings are valid.The reduction in AMI rates observed in Pueblo 1 mirrors findings from Montana 2 and Northern Italy 3both studies demonstrating a rapid decline in AMI after implementing a smoke-free ordinance.Secondly, the absence of personal smoking status among our cohort is a weakness we also acknowledged. 1 We join Dr Vogt's call for public health registries to include a smoking status variable, as it will be interesting to quantify the decrease in AMI among non-smokers.Given the graded risk of passive-smoke exposure in the INTERHEART study, 4 the largest casecontrolled AMI trial, we suspect that much of the reduction in AMI occurs among non-smokers.Finally, we disagree with Dr Vogt's interpretation of the lack of an effect of the ordinance in areas surrounding Pueblo city (El Paso and Pueblo County).A modest drop in AMI rates (15%) was seen in the county (surrounding Pueblo) that lacked an ordinance.Though the decrease failed to reach statistical significance, its magnitude seems clinically significant.We surmise that this relatively smaller decrease in the area surrounding Pueblo suggests that passive smoke exposure was reduced, albeit to a lesser extent, among county residents who often work, dine and recreate in the city of Pueblo.The complete absence of change in AMI rates in El Paso County (contemporaneous control) strengthens this contention and our study's overall results.
Adiponectin in Youth
Authors: Norbert Stefan, Michael Stumvoll, Hans-Ulrich Häring, Andreas Fritsche
Journal: Diabetes Care (2004)

Bacha et al. (1) studied the relationship of serum adiponectin concentrations with hepatic and peripheral insulin sensitivity, body fat distribution, and components of the metabolic syndrome in adolescents. In addition, they reported a negative association between fasting serum proinsulin and the fasting serum proinsulin-to-insulin ratio with adiponectin levels, which was independent of adiposity. They conclude that hypoadiponectinemia may be a marker of β-cell dysfunction.

These data are novel and appear to be suggestive of a primary role of adiponectin in β-cell function. We consider this hypothesis to …
904–49 Children Below 6 Years of Age with Accessory Pathway Related Tachyarrhythmias. Whom to Ablate and How
Authors: Joachim Hebe, Christian Weifß, Jürgen Siebels, Matthias Antz, Riccardo Cappato, Thomas Meinertz, Karl H. Kuck
Journal: Journal of the American College of Cardiology (1995)
The effects of changes in physical activity on major cardiovascular risk factors, hemodynamics, sympathetic function, and glucose utilization in man: a controlled study of four levels of activity.
Authors: G Jennings, L Nelson, P Nestel, M Esler, P Korner, D Burton, J Bazelmans
Journal: Circulation (1986)

The effects of four levels of activity on heart rate, blood pressure, cardiac index, total peripheral resistance index (TPRI), norepinephrine (NE) spillover rate, insulin sensitivity, and levels of lipids and some hormones were studied in 12 normal subjects. The randomized periods were (1) 4 weeks of below-sedentary activity, (2) 4 weeks of sedentary activity, (3) 4 weeks of 40 min of bicycling three times per week, and (4) 4 weeks of similar bicycling seven times per week. Exercise three times per week reduced resting blood pressure by 10/7 mm Hg (p less than .01) and it was reduced by 12/7 mm Hg after exercise seven times per week (both p less than .01). This was associated with reduction in TPRI, an increase in cardiac index, and cardiac slowing. At the highest level of activity, NE spillover rate, an index of sympathetic activity, fell to 35% of the sedentary value (p less than .001) in eight of 10 subjects. In two other subjects NE spillover rate rose, although blood pressure and TPRI were reduced. Metabolic changes included lowering of total cholesterol, but high-density lipoprotein level was unchanged. Insulin sensitivity rose by 27% after exercise three times per week, but declined to sedentary levels with seven times per week exercise. Maximum oxygen uptake increased linearly with activity. Exercise performed three times per week lowers blood pressure and should reduce cardiovascular risk. The same exercise seven times per week enhances physical performance with little further reduction in cardiovascular risk factors. Exercise is potentially a major nonpharmacologic method of lowering blood pressure.
Factors affecting early unplanned readmission of elderly patients to hospital.
Authors: E. I. Williams, F. Fitton
Journal: BMJ (1988)

A random sample of 133 elderly patients who had an unplanned readmission to a district general hospital within 28 days of discharge from hospital was studied and compared with a matched control sample of patients who were not readmitted. The total group was drawn from all specialties in the hospital, and by interviewing the patients, their carers, the ward sisters, and the patients9 general practitioners the factors causing early unplanned readmission for each patient were identified. Seven possible principal reasons were found: relapse of original condition, development of a new problem, carer problems, complications of the initial illness, need for terminal care, problems with medication, and problems with services. There were also contributory reasons, and it was usual for several of these to be present in each case. The unplanned readmission rate was 6%; the planned readmission rate was 3%. It was thought that unplanned readmission was avoidable for 78 (59%) patients. Patients in the study group and in the control group showed significant differences in certain characteristics--such as low income, previous hospital admission, already having nursing care, and admission by general practitioners--and this might help to identify patients who are likely to be readmitted in an emergency.
Daydream for Travis
Authors: Catherine Zickgraf
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Response to Letter Regarding Article, “Longitudinal Strain Delay Index by Speckle Tracking Imaging: A New Marker of Response to Cardiac Resynchronization Therapy”
Authors: Richard A. Grimm, Pascal Lim, Adisai Buakhamsri, Zoran B. Popovic, Neil L. Greenberg, Dimpi Patel, James D. Thomas
Journal: Circulation (2009)

A New Marker of Response to Cardiac Resynchronization Therapy"We thank Dr Jeilan and colleagues for their interest and comments on our investigation of the strain delay index using speckle tracking imaging.Before addressing Dr Jeilan's comments directly, it is important to clarify that the mechanism of cardiac resynchronization therapy effect is speculative.To our knowledge, little, if any, definitive data are available to support the premise that specifically targeting electrical or mechanical delay consistently results in resynchronization and reverse remodeling.Some studies have refuted that premise. 1 Relative to the question on the presystolic segments, time unfortunately precludes the possibility of reanalyzing the strain delay index without inclusion of the presystolic segments for this response.However, it should be noted that we did include a standard deviation calculation in our study of the peak minus the end-systolic strain data over 12 (rather than 16) segments primarily to contrast with the 12-segment tissue Doppler imaging convention reported by Yu and colleagues. 2 The 12-segment standard deviation of strain delay did not favorably compare with the 16-segment strain delay index.These data are represented by a receiver-operator curve in Figure 5. 3 A possible explanation as to why cardiac resynchronization therapy may favorably impact pre-and postsystolic segments may relate to the generation of a new electrical (and, in turn, electrical-mechanical) activation pathway created by an optimally positioned right and left ventricular stimulation.In this model, both early and late activating (by electrical or mechanical means or by a combination of both) segments would be resynchronized relative to an early activating segment.The end result is a change of the end-systolic timing, which will also move the early segment nearer to the end of systole.With regard to Dr Jeilan's interest in seeing data relating to the effect of cardiac resynchronization therapy on the strain delay index, it is unfortunate that we were unable to acquire those data with this cohort.However, we recognize the importance of these data, and they are the subject of an ongoing investigation.
High-Dose Statins and the IDEAL Study
Authors: Hean T. Ong, Jim Seng Cheah
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prostate Tumor Growth Is Impaired by CtBP1 Depletion in High-Fat Diet–Fed Mice
Authors: Cristian P. Moiola, Paola De Luca, Florencia Zalazar, Javier Cotignola, Santiago A. Rodríguez-Seguí, Kevin Gardner, Roberto Meiss, Pablo Vallecorsa, Omar Pignataro, Osvaldo Mazza, Elba S. Vazquez, Adriana De Siervi
Journal: Clinical Cancer Research (2014)

Abstract Purpose: Clinical and epidemiologic data suggest that obesity is associated with more aggressive forms of prostate cancer, poor prognosis, and increased mortality. C-terminal–binding protein 1 (CtBP1) is a transcription repressor of tumor suppressor genes and is activated by NADH binding. High calorie intake decreases intracellular NAD+/NADH ratio. The aim of this work was to assess the effect of high-fat diet (HFD) and CtBP1 expression modulation over prostate xenograft growth. Experimental Design: We developed a metabolic syndrome-like disease in vivo model by feeding male nude mice with HFD during 16 weeks. Control diet (CD)–fed animals were maintained at the same conditions. Mice were inoculated with PC3 cells stable transfected with shCtBP1 or control plasmids. Genome-wide expression profiles and Gene Set Enrichment Analysis (GSEA) were performed from PC3.shCtBP1 versus PC3.pGIPZ HFD-fed mice tumors. Results: No significant differences were observed in tumor growth on CD-fed mice; however, we found that only 60% of HFD-fed mice inoculated with CtBP1-depleted cells developed a tumor. Moreover these tumors were significantly smaller than those generated by PC3.pGIPZ control xenografts. We found 823 genes differentially expressed in shCtBP1 tumors from HFD-fed mice. GSEA from expression dataset showed that most of these genes correspond to cell adhesion, metabolic process, and cell cycle. Conclusions: Metabolic syndrome–like diseases and CtBP1 expression cooperate to induce prostate tumor growth. Hence, targeting of CtBP1 expression might be considered for prostate cancer management and therapy in the subset of patients with metabolic syndromes. Clin Cancer Res; 20(15); 4086–95. ©2014 AACR.
Visualization of Gastrointestinal Bleeding During Tc-99m DTPA Renal Scintigraphy
Authors: EMEL ÖZTÜRK, MEHMET ÖZGÜVEN, ERKAN VARDARELI, BENGÜL GÜNALP, HIKMET BAYHAN
Journal: Clinical Nuclear Medicine (1994)

A 21-year-old man underwent ileolleostomy, and right hemicolectomy following an abdominal gunshot injury. An enterocutaneous fistula developed in the right hypochondrium. The patient started to have melena 7 days after surgery. Melena discontinued 4 days after initialization of medical therapy. On day 15 after the operation, an elevated serum urea level of 75 mg/dL was detected. Tc-99m DTPA renal scintigraphy revealed mildly impaired renal function and an unexpected area of tracer accumulation in the mid and distal right periureteric region suggested the possibility of a urine leakage. However the patient's IVP revealed no urinary tract abnormality. Two days later, a Tc-99m RBC scintigraphy was performed and demonstrated a bleeding site at the same localization, previously interpreted as urine leakage on Tc-99m DTPA renal scintigraphy.
Air pollution during warm weather increases risk of stroke
Authors: J. H. Tanne
Journal: BMJ (2003)

High levels of air pollution, coupled with warm weather, increase ischaemic and haemorrhagic strokes by about 50%, says a study from Kaohsiung Medical University in Taiwan, published online before print in Stroke (http://www.strokeaha.org).

   ![][1] 

Bikers protect themselves from pollution in Kaohsiung

Credit: CHRIS STOWERS/PANOS

The study used a crossover approach to evaluate data on 23 179 admissions to hospital for stroke from 1997 to 2000. It used computerised data from Taiwan's national health insurance plan, which covers 96% of the population, and data from six automated pollution monitoring stations in Kaohsiung.

Kaohsiung, a city of about 1.5 …

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Clinical characteristics of patients with myositis and autoantibodies to different fragments of the Mi-2 antigen
Authors: G J D Hengstman
Journal: Annals of the Rheumatic Diseases (2006)

To assess the clinical implications of autoantibodies directed against different parts of the Mi-2 beta autoantigen in patients with myositis.A systematic assessment of the clinical, laboratory, and histological characteristics of 48 anti-Mi-2 positive patients from six European centres was made. Anti-Mi-2 autoantibodies were determined with an ELISA using four overlapping fragments spanning the entire amino acid sequence of the autoantigen. Data were compared with results for a large group of anti-Mi-2 negative patients with myositis published previously.Anti-Mi-2 autoantibodies were found in dermatomyositis, polymyositis, and inclusion body myositis. In general, myositis with anti-Mi-2 autoantibodies was characterised by relatively mild disease, sometimes accompanied by extra-muscular symptoms, including arthralgia, arthritis, Raynaud's phenomenon, and interstitial lung disease. Cardiac disease was not seen, and treatment response was fair. No differences were found between patients with autoantibodies to different fragments of the Mi-2 beta antigen, except for a potentially increased risk of cancer in patients with antibodies directed to the N-terminal fragment of the autoantigen.Anti-Mi-2 autoantibodies are not a marker of a specific subtype of myositis. No significant differences between patients with autoantibodies to different fragments of the Mi-2 beta autoantigen are found, with the possible exception of an increased risk of cancer in patients with antibodies to the N-terminal fragment.
Applying Brakes to the Runaway American Health Care System
Authors: Nicholas E. Davies
Journal: JAMA (1990)

The American health care system, and especially its cost, is out of control, inhibiting access to care for many, lessening quality of care for some, and creating an almost palpable angst among physicians and others concerned with this enormous national problem. Increased health care rationing in the next decade is inevitable, yet it must not be done with quick fixes, short-term solutions, and patchwork reform of our present system. That would create worse problems for health care in the 21st century and is clearly unacceptable. We recommend that President Bush appoint a blue-ribbon commission to study our present system in depth, then offer alternative solutions for its many problems. He should look closely at at least the following nine issues: controlling medical technology, instituting a resource-based relative value system for physician reimbursement, establishing an ongoing national medical ethics commission, instituting national malpractice reform, implementing universal medical coverage with Medicare/ Medicaid reform, establishing a national health services research and planning institute, reducing the nation's health care facilities, reducing physician supply, and improving health promotion/disease prevention education. (<i>JAMA</i>. 1990;263:73-76)