Treatment of Lupus Erythematosus
Authors: DAVID KAPLAN
Journal: Annals of Internal Medicine (1976)

Comments1 March 1976Treatment of Lupus ErythematosusDAVID KAPLAN, M.D., HERBERT S. DIAMOND, M.D., ELLEN M. GINZLER, M.D.DAVID KAPLAN, M.D.Search for more papers by this author, HERBERT S. DIAMOND, M.D.Search for more papers by this author, ELLEN M. GINZLER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-84-3-337 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Two clinical studies and an editorial in the November 1975 Annals (1-3) and another study cited (4, 5) conclude that azathioprine is of no demonstrable benefit in the management of patients with lupus nephritis—disagreeing with two other reports (6, 7). It is true that if a large number of clinics each study an ineffective drug in a small number of patients, it is likely that, by chance, a few clinics will show a "statistical" advantage of the drug. It is equally true, however, that among the same clinics studying an effective drug, each again in a small...References Reference1. HAHNKANTOROSTERLAND BOC: Azathioprine plus prednisone compared with prednisone alone in the treatment of systemic lupus erythematosus. Report of a prospective controlled trial in 24 patients. Ann Intern Med 83:597-605, 1975 LinkGoogle Scholar2. DECKERKLIPPELPLOTZ JJP: Cyclophosphamide or azathioprine in lupus glomerulonephritis. A controlled trial: results at 28 months. Ann Intern Med 83:606-615, 1975 LinkGoogle Scholar3. ROTHFIELD N: Immunosuppressive therapy in lupus erythematosus. Ann Intern Med 83:727-728, 1975 LinkGoogle Scholar4. DONADIOHOLLEYWAGONER JKR: Treatment of lupus nephritis with prednisone and combined prednisone and azathioprine. Ann Intern Med 77:829-835, 1972 LinkGoogle Scholar5. DONADIOHOLLEYWAGONER JKR: Further observations on the treatment of lupus nephritis with prednisone and combined prednisone and azathioprine. Arthritis Rheum 17:573-581, 1974 CrossrefMedlineGoogle Scholar6. SZTEJNBOKSTEWARTDIAMOND MAH: Azathioprine in the treatment of systemic lupus erythematosus: a controlled study. Arthritis Rheum 14:639-645, 1971 CrossrefMedlineGoogle Scholar7. CADESPOONERSCHLEIN RGG: Comparison of azathioprine, prednisone, and heparin along or combined in treating lupus nephritis. Nephron 10:37-56, 1973 CrossrefMedlineGoogle Scholar1. BALDWINLOWENSTEINROTHFIELD DJN: The clinical course of the proliferative and membranous forms of lupus nephritis. Ann Intern Med 73:929-942, 1970 LinkGoogle Scholar1. DUBOISWIERSCHOWIECKICOX EMB: Causes of death in 212 cases of systemic lupus erythematosus (abstract). Arthritis Rheum 16:540-541, 1973 Google Scholar2. CHEATUMHURDSTRUNK DES: Renal histology and clinical course of systemic lupus erythematosus. A prospective study. Arthritis Rheum 16:670-676, 1973 CrossrefMedlineGoogle Scholar3. EPSTEINGRAUSZ WH: Favorable outcome in diffuse proliferative glomerulonephritis of systemic lupus erythematosus. Arthritis Rheum 17:129-141, 1974 CrossrefMedlineGoogle Scholar4. BALDWINLOWENSTEINROTHFIELD DJN: The clinical course of the proliferative and membranous forms of lupus nephritis. Ann Intern Med 73:929-942, 1970 LinkGoogle Scholar5. DONADIOHOLLEYWAGONER JKR: Treatment of lupus nephritis with prednisone and combined prednisone and azathioprine. Ann Intern Med 77:829-835, 1972 LinkGoogle Scholar6. DONADIOHOLLEYWAGONER JKR: Further observations on the treatment of lupus nephritis with prednisone and combined prednisone and azathioprine. Arthritis Rheum 17:573-581, 1974 CrossrefMedlineGoogle Scholar7. CADESPOONERSCHLEIN RGE: Comparison of azathioprine, prednisone and heparin alone or combined in treating lupus nephritis. Nephron 10:37-56, 1973 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine State University of New York Downstate Medical Center Brooklyn, New York 11203 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1976Volume 84, Issue 3Page: 337-338KeywordsDrugsLupus erythematosus Issue Published: 1 March 1976 PDF DownloadLoading ...