Phenotypic Characterization of Cutaneous Infiltrates
Authors: CRAIG A. ELMETS
Journal: Annals of Internal Medicine (1983)

Editorials1 September 1983Phenotypic Characterization of Cutaneous InfiltratesCRAIG A. ELMETS, M.D.CRAIG A. ELMETS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-99-3-406 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptImmunopathologic assessment of antibody and complement deposition in the skin has become an essential procedure in the diagnosis of cutaneous diseases such as lupus erythematosus, pemphigus, bullous pemphigoid, and cutaneous vasculitis. The in-situ characterization of mononuclear cells in inflammatory and neoplastic infiltrates of the skin should be an equally important probe for the analysis of other cutaneous and systemic disorders. This new ability to identify mononuclear cell subsets in histologic sections of skin results largely from the production of monoclonal antibodies that segregate subpopulations of immunocompetent cells with distinct cell surface markers. Although phenotypic markers do not always correlate with...References1. REINHERZKUNGGOLDSTEINLEVEYSCHLOSSMAN EPGRS. Discrete stages of human intrathymic differentiation: analysis of normal thymocytes and leukemic lymphoblasts of T-cell lineage. Proc Natl Acad Sci USA. 1980;77:1588-92. CrossrefMedlineGoogle Scholar2. BRODEREDELSONLUTZNER SRM. The Sezary syndrome: a malignant proliferation of helper T cells. J Clin Invest. 1976;58:1297-1306. CrossrefMedlineGoogle Scholar3. KUNGBERGERGOLDSTEINLOGERFOEDELSON PCGPR. Cutaneous T cell lymphoma: characterization by monoclonal antibodies. Blood. 1981;57:261-6. CrossrefMedlineGoogle Scholar4. HAYNESMETZGARMINNABUNN BRJP. Phenotypic characterization of cutaneous T-cell lymphoma: use of monoclonal antibodies to compare with other malignant T cells. N Engl J Med. 1981;304:1319-23. CrossrefMedlineGoogle Scholar5. HAYNESHENSLEYJEGASOTHY BLB. Differentiation of human T lymphocytes: II. Phenotypic difference in skin and blood malignant T-cells in cutaneous T-cell lymphoma. J Invest Dermatol. 1982;78:323-6. CrossrefMedlineGoogle Scholar6. BAERBERMAN RB. Role of Langerhans cells in cutaneous immunological reactions. In: SAFAI B, GOOD RA, eds. Immunodermatology. New York: Plenum Publishing Corp; 1981: 467-82. CrossrefGoogle Scholar7. THOMASJANOSSYGRAHAM-BROWNKUNGGOLDSTEIN JGRPG. The relationship between T lymphocyte subsets and Ia-like antigen positive nonlymphoid cells in early stages of cutaneous T cell lymphoma. J Invest Dermatol. 1982;78:169-76. CrossrefMedlineGoogle Scholar8. BERGERMORRISONCHU CSA. Diagnosis of cutaneous T cell lymphoma by use of monoclonal antibodies reactive with tumor-associated antigens. J Clin Invest. 1982;70:1205-15. CrossrefMedlineGoogle Scholar9. HANIFIN J. Atopic dermatitis. J Am Acad Dermatol. 1982;6:1-13. CrossrefMedlineGoogle Scholar10. LEUNGRHODESGEHA DAR. Enumeration of T cell subsets in atopic dermatitis using monoclonal antibodies. J Allergy Clin Immunol. 1981;67:450-5. CrossrefMedlineGoogle Scholar11. LEUNGBHANSCHNEEBERGERGEHA DAER. Characterization of the mononuclear cell infiltrate in atopic dermatitis using monoclonal antibodies. J Allergy Clin Immunol. 1983;71:47-56. CrossrefMedlineGoogle Scholar12. VAN VOORHISKAPLANSARNO WGE. The cutaneous infiltrates of leprosy: cellular characteristics and the predominant T-cell phenotypes. N Engl J Med. 1982;307:1593-7. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: CRAIG A. ELMETS, M.D.Affiliations: Case Western Reserve University Cleveland, Ohio PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe System Boron-Oxygen 1 September 1983Volume 99, Issue 3Page: 406-407KeywordsCellsLupus erythematosusMonoclonal antibodiesVasculitis ePublished: 1 December 2008 Issue Published: 1 September 1983 PDF downloadLoading ...