Membranous Glomerulonephritis as a Complication of Oral Gold Therapy
Authors: JUAN J. PLAZA
Journal: Annals of Internal Medicine (1982)

Brief Reports1 October 1982Membranous Glomerulonephritis as a Complication of Oral Gold TherapyJUAN J. PLAZA, M.D., GABRIEL HERRERO, M.D., ANTONIO BARAT, Ph.D., JUAN J. LOUTAIF, M.D., LUIS HERNANDO, Ph.D., PEDRO VALLADO, M.D., HORACIO OLIVA, Ph.D.JUAN J. PLAZA, M.D.Search for more papers by this author, GABRIEL HERRERO, M.D.Search for more papers by this author, ANTONIO BARAT, Ph.D.Search for more papers by this author, JUAN J. LOUTAIF, M.D.Search for more papers by this author, LUIS HERNANDO, Ph.D.Search for more papers by this author, PEDRO VALLADO, M.D.Search for more papers by this author, HORACIO OLIVA, Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-97-4-563 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptParenteral gold compounds are usually successful in the treatment of patients with rheumatoid arthritis, but renal complications such as transient proteinuria and nephrotic syndrome (affecting 10% to 31% and 0.2% to 2.6% of patients, respectively) sometimes force discontinuation of the treatment (1, 2).Auronafin (Smith Kline & French Laboratories, Philadelphia, Pennsylvania), an oral preparation containing gold (2, 3, 4, 6 tetra-O-acetyl-l-thio-B-D-glucopyranosato-s) (triethyl phosphine) has been proposed to be as effective as the injectable compounds with the additional advantage of being almost free from side effects; microscopic haematuria and proteinuria have occurred rarely. (Smith Kline & French Laboratories; data on file.)...References1. VAAMONDEHUNT CF. The nephrotic syndrome as a complication of gold therapy. Arthritis Rheum. 1970;13:826-34. CrossrefMedlineGoogle Scholar2. SILVERBERGKIDDSHNITKAULAN DETR. Gold nephropathy: a clinical and pathologic study. Arthritis Rheum. 1970;13:812-25. CrossrefMedlineGoogle Scholar3. REVACHFREEDEHRLICH MRG. Reversible proteinuria as a complication of oral gold therapy. Arthritis Rheum. 1979;22:1417-8. CrossrefMedlineGoogle Scholar4. LAWRENCE J. Studies with radioactive gold. Ann Rheum Dis. 1961;20:341-52. CrossrefMedlineGoogle Scholar5. GOTTLIEBSMITHSMITH NPE. Pharmacodynamics of 197Au 195Au labeled aurothiomalate in blood: correlation with a course of rheumatoid arthritis, gold toxicity, and gold excretion. Arthritis Rheum. 1974;17:171-83. CrossrefMedlineGoogle Scholar6. STRUNKZIFF SM. Ultrastructural studies of the passage of gold thiomalate across the renal glomerular capillary wall. Arthritis Rheum. 1970;13:39-52. CrossrefMedlineGoogle Scholar7. SAMUELSLEEENGLEMANHOPPER BJEJ. Membranous nephropathy in patients with rheumatoid arthritis: relationship to gold therapy. Medicine. 1978;57:319-27. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Universidad Autonoma de Madrid Madrid Spain PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByImmunotoxicology of MetalsGold salts, D-penicillamine and allopurinolGold salts, D-penicillamine and allopurinolNephrotoxicity of gold salts, D-penicillamine, and allopurinolRenal biopsy findings and clinicopathologic correlations in rheumatoid arthritisDrug-Induced Renal DisordersAntiinflammatory and Immunosuppressive Drugs in the Treatment of Rheumatoid ArthritisHypersensitivity Phenomena and the Kidney: Role of Drugs and Environmental AgentsProteinuria in Gold-Treated Rheumatoid ArthritisWARREN A. KATZ, M.D., RANDOLPH C. BLODGETT Jr., M.D., ROBERT G. PIETRUSKO, Pharm.D.Auranofin in juvenile rheumatoid arthritis. An open label, non-controlled studyGold nephropathy due to auranofin obscured by tolmetin pseudoproteinuria.Auranofin: A unique oral chrysotherapeutic agentMetals 1 October 1982Volume 97, Issue 4Page: 563-564KeywordsGlomerulonephritisInformation storage and retrievalPatientsProteinuriaRheumatoid arthritis Issue Published: 1 October 1982 PDF DownloadLoading ...