Recurrent Hypomagnesemia With Proton-Pump Inhibitor Rechallenge
Authors: Maria Quasdorff, Jessica Mertens, Johanna Dinter, Hans-Michael Steffen
Journal: Annals of Internal Medicine (2011)

Letters20 September 2011Recurrent Hypomagnesemia With Proton-Pump Inhibitor RechallengeMaria Quasdorff, MD PhD, Jessica Mertens, MD, Johanna Dinter, MD, and Hans-Michael Steffen, MDMaria Quasdorff, MD PhDFrom University Hospital Cologne, Cologne 50924, Germany.Search for more papers by this author, Jessica Mertens, MDFrom University Hospital Cologne, Cologne 50924, Germany.Search for more papers by this author, Johanna Dinter, MDFrom University Hospital Cologne, Cologne 50924, Germany.Search for more papers by this author, and Hans-Michael Steffen, MDFrom University Hospital Cologne, Cologne 50924, Germany.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-155-6-201109200-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Background: Clinicians frequently prescribe proton-pump inhibitors (PPIs) for patients with gastroesophageal reflux disease, gastritis, duodenitis, and peptic ulcer disease without considering the potential for severe side effects. Other observers have reported 4 cases of tetany due to hypocalcemia secondary to hypomagnesemia associated with a PPI (1–3).Objective: To provide additional support for the association between PPIs and hypomagnesemia.Case Report: We admitted a 30-year-old woman with Crohn disease whose history included a partial ileal resection and newly detected rectovaginal fistula. Physical examination showed diffuse abdominal tenderness and a blood pressure of 125/80 mm Hg. Blood tests revealed mild hypomagnesemia (magnesium ...References1. Subbiah V, Tayek JA. Tetany secondary to the use of a proton-pump inhibitor [Letter]. Ann Intern Med. 2002;137:219. [PMID: 12160379] LinkGoogle Scholar2. Epstein M, McGrath S, Law F. Proton-pump inhibitors and hypomagnesemic hypoparathyroidism [Letter]. N Engl J Med. 2006;355:1834-6. [PMID: 17065651] CrossrefMedlineGoogle Scholar3. Shabajee N, Lamb EJ, Sturgess I, Sumathipala RW. Omeprazole and refractory hypomagnesaemia. BMJ. 2008;337:a425. [PMID: 18617497] CrossrefMedlineGoogle Scholar4. Swaminathan R. Magnesium metabolism and its disorders. Clin Biochem Rev. 2003;24:47-66. [PMID: 18568054] MedlineGoogle Scholar5. Touyz RM. Role of magnesium in the pathogenesis of hypertension. Mol Aspects Med. 2003;24:107-36. [PMID: 12537992] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From University Hospital Cologne, Cologne 50924, Germany.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoTetany Secondary to the Use of a Proton-Pump Inhibitor Vishakalakshmi Subbiah and John A. Tayek Metrics Cited byProton Pump Inhibitors and the Kidney: Implications of Current Evidence for Clinical Practice and When and How to DeprescribeEffect of prolonged omeprazole administration on segmental intestinal Mg 2+ absorption in male Sprague-Dawley ratsHypomagnesemia and Hypocalcemia Caused by Proton-Pump Inhibitors Long-Term TherapyProton pump inhibitor use is not associated with cardiac arrhythmia in critically ill patientsImpact of proton pump inhibitor use on magnesium homoeostasis: a cross-sectional study in a tertiary emergency departmentThe association of proton pump inhibitors and hypomagnesemia in the community settingGastrointestinal drugsAn update on the importance of monitoring serum magnesium in advanced disease patientsOut-of-Hospital Use of Proton Pump Inhibitors and Hypomagnesemia at Hospital Admission: A Nested Case-Control StudyEfficacy and Safety of Proton Pump Inhibitors in the Management of Pediatric Gastroesophageal Reflux DiseaseHypomagnesemia and proton-pump inhibitorsPerils and pitfalls of long-term effects of proton pump inhibitorsProton Pump Inhibitor–Associated Hypomagnesemia: What Do FDA Data Tell Us?Magnesium homeostasis and hypomagnesemia in children with malignancyProton-pump inhibitor use is associated with low serum magnesium concentrationsHypomagnesemia as a possible explanation behind episodes of severe pain in cancer patients receiving palliative careModeling and Simulation of the Effect of Proton Pump Inhibitors on Magnesium Homeostasis. 1. Oral Absorption of MagnesiumTetany, Hypomagnesemia, and Proton-pump InhibitorsSystematic review: hypomagnesaemia induced by proton pump inhibitionProton-Pump Inhibitor-Induced Hypocalcemia and Hypomagnesemia 20 September 2011Volume 155, Issue 6Page: 405-407KeywordsBlood pressureCalciumCrohn's diseaseGastritisHematologic testsHypertensionHypomagnesemiaMagnesiumPatients ePublished: 20 September 2011 Issue Published: 20 September 2011 Copyright & PermissionsCopyright © 2011 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...