tbuckley/cabot-search huggingface dataset:
505 DONOR IL28B TT-POLYMORPHISM IS ASSOCIATED WITH INCREASED INCIDENCE OF HEPATIC STEATOSIS IN LIVER TRANSPLANT PATIENTS WITH CHRONIC HEPATITIS C
Authors: B.J. Veldt, A. Duarte-Rojo, A.J. Thompson, J.K. Heimbach, H.L.A. Janssen, H.L. Tillmann, D.D. Goldstein, J.G. McHutchison, M.R. Charlton
Journal: Journal of Hepatology (2013)
The Need to Revisit VTE Quality Measures
Authors: Christine V. Kinnier, Cindy Barnard, Karl Y. Bilimoria
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Comparison of adenoma detection and miss rates between a novel balloon colonoscope and standard colonoscopy: a randomized tandem study
Authors: Zamir Halpern, Seth Gross, Ian Gralnek, Beni Shpak, Mark Pochapin, Arthur Hoffman, Meir Mizrahi, Yosef Rochberger, Menachem Moshkowitz, Erwin Santo, Alaa Melhem, Roman Grinshpon, Jorge Pfefer, Ralf Kiesslich
Journal: Endoscopy (2015)

Correction to: Comparison of adenoma detection and miss rates between a novel balloon colonoscope and standard colonoscopy: a randomized tandem studyEndoscopy 2015; 10(03): 238-244DOI: 10.1055/s-0034-1391437
Anxiety neuroses and phobic states. II. Diagnosis and management.
Authors: M. Roth, D. H. Myers
Journal: BMJ (1969)

In anxiety neurosis there are disturbances both of mental life and of body function.This duality is reflected in its investiga- tion with equal profit by psychological and physiological means, in its contemporary treatment, which combines drugs, psychotherapy, behaviour therapy, and very occasionally psychosurgery, and in its differential diagnosis, which includes both mental and physical disturbance.
Liver regeneration. Edited By D. Bernuau and G. Feldman, 161 Pp. Paris: John Libbey Eurotext, 1992. $33
Authors: Jonathan M. Koff
Journal: Hepatology (1993)

REVIEWShistological findings waa not indicated in many of the descriptions and that tables of the distribution of lesions were not provided.The latter is a feature increasingly expected of pathology descriptions.The recent Atlas of
Increased risk of serious pneumococcal disease in patients with atopic conditions other than asthma
Authors: Ji A. Jung, Hirohito Kita, Barbara P. Yawn, Thomas G. Boyce, Kwang H. Yoo, Michaela E. McGree, Amy L. Weaver, Peter Wollan, Robert M. Jacobson, Young J. Juhn
Journal: Journal of Allergy and Clinical Immunology (2010)
A CALCIUM SCORE OF ZERO HAS A HIGH NEGATivE PREDICTIVE VALUE FOR EXCLUDING SEVERE CORONARY ARTERY STENOSIS IN SYMPTOMATIC PATIENTS IN AN ASIAN POPULATION
Authors: Yu Ling Tay, Terrance Chua, John Allen, Apurva Thanju, Swee Yaw Tan
Journal: Journal of the American College of Cardiology (2013)
TLR4, but not TLR2, mediates IFN-β–induced STAT1α/β-dependent gene expression in macrophages
Authors: Vladimir Toshchakov, Bryan W. Jones, Pin-Yu Perera, Karen Thomas, M. Joshua Cody, Shuling Zhang, Bryan R. G. Williams, Jennifer Major, Thomas A. Hamilton, Matthew J. Fenton, Stefanie N. Vogel
Journal: Nature Immunology (2002)
Abstract 369: Tumor detection and surgical navigation with fluorescence laparoscopy is enhanced with combinations of differently labeled fluorophore-conjugated antibodies and fluorescent proteins
Authors: Cristina A. Metildi Raimo, Sharmeela Kauhsal, Cynthia S. Snyder, George A. Luiken, Robert M. Hoffman, Michael Bouvet
Journal: Cancer Research (2012)

Abstract The aim of this study was to improve detection of primary and metastatic lesions of human pancreatic cancer in mouse models with fluorescence laparoscopy by enhancing the fluorescence signal of tumor with different combinations of fluorophores without compromising background illumination. Human pancreatic cancer models were established with combinations of FG-RFP, MiaPaca2-GFP, BxPC-3-RFP, or BxPC-3 cancer cells implanted in 6-week-old female athymic mice. Two weeks post-implantation, diagnostic laparoscopy was performed with a Stryker L9000 LED light source 24 hours after tail vein injection of CEA antibodies conjugated with Alexa 488- and/or Alexa 555. Cancer lesions were detected and localized under the fluorescence light mode. Intravital images were obtained with the Maestro CRI Small Animal Imaging System, serving as a positive control. Tumors were collected for histologic review. Fluorescence laparoscopy with a 495-nm emission filter and an LED light source enabled real-time visualization of differently fluorescence-labeled tumors in the peritoneal cavity simultaneously. The combination of BxPC-3 RFP labeled with anti-CEA-Alexa 488 afforded the brightest signal of all established mouse models. We were able to reproduce this enhanced fluorescence signaling by doubly labeling non-color BxPC-3 tumor with anti-CEA-Alexa 488 and anti-CEA-Alexa 555. The doubly labeled tumor provided a greater signal intensity profile compared to tumors labeled with either anti-CEA-Alexa 488 or -Alexa 555 alone. This enhanced fluorescence signal permitted improved detection of sub-millimeter lesions without compromising background illumination. The ability to visualize tumor deposits expressing fluorescent proteins of different wavelengths simultaneously with an LED light source enabled us to establish the optimal combination of fluorophores that enhanced the signal intensity of fluorescence. With this optimal fluorophore combination, we improved the detection of sub-millimeter tumor lesions without impairing the visualization of surrounding structures necessary for surgical navigation. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 369. doi:1538-7445.AM2012-369
Priority in Use of Atoxyl.
Authors: E. N. Tobey
Journal: JAMA (1907)

Liverpool, Dec. 21, 1906. <h3>To the Editor:</h3> —Reports have been repeatedly published of late which ascribe to Dr. Koch the discovery of a drug, atoxyl, which has a curative action in the treatment of human trypanosomiasis. The London<i>Times</i>has copied an article to this effect from the Cologne<i>Gazette</i>, and the London<i>Standard</i>has printed a similar article from its Berlin correspondent. These articles have been widely circulated and they lead the public to believe that Dr. Koch was the first to use this remedy in trypanosomiasis. It may be of interest to your readers to know that the beneficial action of atoxyl in experimental trypanosomiasis was discovered by the Liverpool School of Tropical Medicine and that its use has been steadily and publicly advocated by the staff of this school for the past year and a half. The first work of Dr. Thomas on this use of atoxyl
DNA adducts and related biomarkers in populations exposed to environmental carcinogens
Authors: Frederica Perera, Diane Brenner, Alan Jeffrey, Jack Mayer, Deliang Tang, Dorothy Warburton, Tie-lan Young, Leila Wazneh, Louise Latriano, Grazyna Motykiewicz, Ewa Grzybowska, Mieczyslaw Chorazy, Kari Hemminki, Regina Santella
Journal: Environmental Health Perspectives (1992)

Prevention of environmentally related cancer will be enhanced by the availability of sensitive early warning systems and by improvements in quantitative assessment of human risks. Accordingly, we have carried out a series of molecular epidemiologic studies aimed at validating a panel of biologic markers, including carcinogen–DNA and –protein adducts, sister chromatid exchange, micronucleus formation, DNA strand breaks, and DNA repair capacity. Results from three such studies illustrate the usefulness of these biomarkers in elucidating low-dose–response relationships, correlations between biomarkers, and the range of variation in biomarkers between individuals exposed to similar concentrations of carcinogens. Low-level workplace or ambient exposures to styrene, ethylene oxide, and polycyclic aromatic hydrocarbons (PAH) were associated with significant increases in both molecular dose of carcinogens (adducts) and various markers of preclinical effects. Correlations between biomarkers varied by exposure. For example, in the styrene study, sister chromatid exchange frequency was not correlated with any of the markers, in contrast to the studies of ethylene oxide and PAH. Significant molecular effects were observed not only in occupationally exposed people but also in residents of an area in Poland characterized by high levels of air pollution. For example, the mean PAH–DNA level in exposed residents (winter sample) was 30.4 adducts per 108 nucleotides. This level was significantly higher than that of adducts seen in summer samples from the same area (4.2/108), or in winter samples from residents of a rural area (11.01/108). Significant seasonal variation in PAH–DNA adduct formation in this group was consistent with recorded fluctuations in air pollution levels. Striking interindividual variation was observed in all three exposed populations.
IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice
Authors: John S. Cho, Eric M. Pietras, Nairy C. Garcia, Romela Irene Ramos, David M. Farzam, Holly R. Monroe, Julie E. Magorien, Andrew Blauvelt, Jay K. Kolls, Ambrose L. Cheung, Genhong Cheng, Robert L. Modlin, Lloyd S. Miller
Journal: Journal of Clinical Investigation (2010)

Staphylococcus aureus is the most common cause of skin and soft tissue infections, and rapidly emerging antibiotic-resistant strains are creating a serious public health concern. If immune-based therapies are to be an alternative to antibiotics, greater understanding is needed of the protective immune response against S. aureus infection in the skin. Although neutrophil recruitment is required for immunity against S. aureus, a role for T cells has been suggested. Here, we used a mouse model of S. aureus cutaneous infection to investigate the contribution of T cells to host defense. We found that mice deficient in gammadelta but not alphabeta T cells had substantially larger skin lesions with higher bacterial counts and impaired neutrophil recruitment compared with WT mice. This neutrophil recruitment was dependent upon epidermal Vgamma5+ gammadelta T cell production of IL-17, but not IL-21 and IL-22. Furthermore, IL-17 induction required IL-1, TLR2, and IL-23 and was critical for host defense, since IL-17R-deficient mice had a phenotype similar to that of gammadelta T cell-deficient mice. Importantly, gammadelta T cell-deficient mice inoculated with S. aureus and treated with a single dose of recombinant IL-17 had lesion sizes and bacterial counts resembling those of WT mice, demonstrating that IL-17 could restore the impaired immunity in these mice. Our study defines what we believe to be a novel role for IL-17-producing epidermal gammadelta T cells in innate immunity against S. aureus cutaneous infection.
Refining the Art and Science of Coronary Stenting
Authors: Stephen G. Ellis
Journal: New England Journal of Medicine (2009)

The broad goals of treatment for patients with coronary artery disease are improvement in survival and a reduction in the risk of myocardial infarction and symptoms of coronary disease. The circumstances under which revascularization with the use of percutaneous coronary intervention (PCI) or bypass surgery is needed, and the optimal means of providing revascularization for patients with multivessel coronary disease, remain enigmatic. Much of our evidence base is badly outdated.1,2 Fortunately, several large clinical trials are under way, and early results of some of these trials are available. For example, the 1-year results of the SYNTAX (Synergy between Percutaneous . . .
Care of an Unresponsive Patient with a Poor Prognosis
Authors: Arthur S. Slutsky, Leonard D. Hudson
Journal: New England Journal of Medicine (2009)

Case VignetteA 56-year-old homeless man was found having a seizure and was transported to the hospital. He was found to have a subarachnoid hemorrhage and acute hydrocephalus. He underwent intubation, and mechanical ventilation was started. A shunt was placed to relieve the hydrocephalus; cerebral angiography revealed a ruptured aneurysm of the anterior communicating cerebral artery and an unruptured aneurysm of the posterior cerebral artery. The patient had a score of 5 on the Glasgow Coma Scale. The neurosurgeon stated that without clipping of the aneurysm there was a 50% chance of recurrence of bleeding in the next 6 months, . . .
Calcification by MC3T3-E1 cells on RGD peptide immobilized on titanium through electrodeposited PEG
Authors: Kei Oya, Yuta Tanaka, Haruka Saito, Kazuya Kurashima, Kazuya Nogi, Harumi Tsutsumi, Yusuke Tsutsumi, Hisashi Doi, Naoyuki Nomura, Takao Hanawa
Journal: Biomaterials (2008)
Opinion Leaders vs Audit Feedback to Implement Practice Guidelines
Authors: Edward Ellerbeck
Journal: JAMA (1991)

<h3>To the Editor.</h3> —Lomas et al<sup>1</sup>looked at two different methods of changing medical practices that had not been influenced by explicit practice guidelines. In this innovative study, the authors found that physicians in hospitals receiving an opinion leader education (OLE) intervention were less likely to perform inappropriate cesarean sections than physicians in control hospitals and hospitals receiving audit and feedback. Two aspects of the design and analysis of this study, however, make it difficult to determine whether or not the better compliance with cesarean section guidelines in the OLE group was actually due to the influence of the opinion leader on his or her fellow physicians. First, the higher compliance with cesarean section guidelines in the OLE group may have been due to the practices of the opinion leaders themselves. The four opinion leaders received 1½ days of intense training in the guidelines for performance of cesarean sections;
Double-blind placebo-controlled study of loperamide (Imodium) in chronic diarrhoea caused by ileocolic disease or resection.
Authors: P Mainguet, R Fiasse
Journal: Gut (1977)

Loperamide (R 18 553) was compared with placebo in a double-blind crossover study of 21 patients with chronic diarrhoea caused by ileocolic disease or resection. Eighteen patients completed the trial. At a median daily dose of 6 mg the new antidiarrhoeal preparation was found to be superior to placebo in controlling chronic diarrhoea. The frequency and weight of stools significantly decreased, the stools became more solid, and carmine transit time was prolonged during loperamide therapy. Loperamide was consistently preferred to placebo by the patients. Gastrointestinal side-effects were few and comparable during both treatment periods.
Robot-Assisted Radical Cystectomy with Intracorporeal Urinary Diversion in Patients with Transitional Cell Carcinoma of the Bladder
Authors: Martin N. Jonsson, L. Christofer Adding, Abolfazl Hosseini, Martin C. Schumacher, Daniela Volz, Andreas Nilsson, Stefan Carlsson, N. Peter Wiklund
Journal: European Urology (2011)
Injectable and Oral Contraceptive Use and Cancers of the Breast, Cervix, Ovary, and Endometrium in Black South African Women: Case–Control Study
Authors: Margaret Urban, Emily Banks, Sam Egger, Karen Canfell, Dianne O'Connell, Valerie Beral, Freddy Sitas
Journal: PLoS Medicine (2012)

Oral contraceptives are known to influence the risk of cancers of the female reproductive system. Evidence regarding the relationship between injectable contraceptives and these cancers is limited, especially in black South Africans, among whom injectable contraceptives are used more commonly than oral contraceptives.We analysed data from a South African hospital-based case-control study of black females aged 18-79 y, comparing self-reported contraceptive use in patients with breast (n = 1,664), cervical (n = 2,182), ovarian (n = 182), and endometrial (n = 182) cancer, with self-reported contraceptive use in 1,492 control patients diagnosed with cancers with no known relationship to hormonal contraceptive use. We adjusted for potential confounding factors, including age, calendar year of diagnosis, education, smoking, alcohol, parity/age at first birth, and number of sexual partners. Among controls, 26% had used injectable and 20% had used oral contraceptives. For current and more recent users versus never users of oral or injectable contraceptives, the odds ratios (ORs) for breast cancer were significantly increased in users of oral and/or injectable contraceptives (OR 1.66, 95% CI 1.28-2.16, p<0.001) and separately among those exclusively using oral (1.57, 1.03-2.40, p = 0.04) and exclusively using injectable (OR 1.83, 1.31-2.55, p<0.001) contraceptives; corresponding ORs for cervical cancer were 1.38 (1.08-1.77, p = 0.01), 1.01 (0.66-1.56, p = 0.96), and 1.58 (1.16-2.15, p = 0.004). There was no significant increase in breast or cervical cancer risk among women ceasing hormonal contraceptive use ≥10 y previously (p = 0.3 and p = 0.9, respectively). For durations of use ≥5 y versus never use, the ORs of ovarian cancer were 0.60 (0.36-0.99, p = 0.04) for oral and/or injectable contraceptive use and 0.07 (0.01-0.49, p = 0.008) for injectable use exclusively; corresponding ORs for endometrial cancer were 0.44 (0.22-0.86, p = 0.02) and 0.36 (0.11-1.26, p = 0.1).In this study, use of oral and of injectable hormonal contraceptives was associated with a transiently increased risk of breast and cervical cancer and, for long durations of use, with a reduced risk of ovarian and endometrial cancer. The observed effects of injectable and of oral contraceptives on cancer risk in this study did not appear to differ substantially.
Detection of bone metastases in carcinoma of bronchus.
Authors: S J Williams, M Green, I M Kerr
Journal: BMJ (1977)

per year-Knight considered that some areas of the United Kingdom, including the temperate west counties, north Wales, and north-west Cheshire may have sufficient warmth and humidity to harbour the yeast in fertile environments.5These tend to be soil infested with animal matter-chicken coops, starling roosts, and caves rich in bat guano.Seven years before admission our patient killed a bat that entered his room in a nineteenth century Somerset house, but no febrile illness followed this event.He otherwise denied hobbies or activities that could lead to exposure to potentially infected material.Closer questioning about his wartime exploits, however, re- vealed several visits to the Elephanta caves outside Bombay in 1945.The implication of bat infection at this source would presume a 30-year interval between acquiring the organism and the development of clinical symptoms.Presumably if this were
Effect of acute alterations in inspired oxygen tension on methacholine induced bronchoconstriction in patients with asthma
Authors: K. D. Dagg, L. J. Thomson, R. A. Clayton, S. G. Ramsay, N. C. Thomson
Journal: Thorax (1997)

Recent in vitro and in vivo studies in animals have suggested that ambient oxygen tension may influence airway responsiveness to bronchoconstrictor stimuli. These observations may have relevance to the management of acute exacerbations of asthma. The present studies were designed to examine the influence of inspired oxygen tension (Fio2 1.0, 0.21, 0.15) on methacholine-induced broncho-constriction in patients with asthma.In a dual study two groups of asthmatic patients performed methacholine inhalation challenges breathing either air (Fio2 0.21) or a hypoxic gas mixture (Fio2 0.15) in study 1 and air (Fio2 0.21) or hyperoxia (Fio2 1.0) in study 2. The gases were administered through a closed breathing circuit in a randomised double blind fashion. The PC20 values (dose of methacholine causing a 20% fall in forced expiratory volume in one second (FEV1) were calculated after each methacholine challenge by linear interpolation from the logarithmic dose response curve. Plasma catecholamine levels were measured before and after methacholine challenges as well as heart rate, oxygen saturation, and percentage end tidal carbon dioxide levels.The geometric mean PC20 value for methacholine was significantly lower on the hypoxic study day than on the normoxic day in study 1 (mean difference in PC20 values 2.88 mg/ml (95% CI 1.4 to 5.3); p < 0.05), but there was no significant difference in the geometric mean PC20 value for methacholine between the hyperoxic and normoxic study days in study 2 (mean difference in PC20 values 1.45 mg/ ml (95% CI 0.83 to 2.51)).Acute hypoxia potentiates methacholine induced bronchoconstriction and acute hyperoxia has no effect in mild to moderate patients with stable asthma.
Predictive Value of Cardiac Troponin I and T for Subsequent Death in End-Stage Renal Disease
Authors: Fred S. Apple, MaryAnn M. Murakami, Lesly A. Pearce, Charles A. Herzog
Journal: Circulation (2002)

This study determined the prevalence of increased cardiac troponin I (cTnI) and T (cTnT) in end-stage renal disease (ESRD) patients and whether an increased troponin was predictive of death.Serum was obtained from 733 ESRD patients and measured for cTnI and cTnT. Relative risks were estimated using Cox proportional hazards regressions univariately and adjusted for age, time on dialysis, and coronary artery disease. Kaplan-Meier curves compared time to event data between groups. Greater percentages of patients had an increased cTnT versus cTnI at each cutoff, as follows: 99th percentile, 82% versus 6%; 10% coefficient of variation, 53% versus 1.0%; and receiver operator characteristic, 20% versus 0.4%. Increased versus normal cTnT was predictive of increased mortality using all cutoffs and only above the 99th percentile for cTnI. Two-year cumulative mortality rates increased (P<0.001) with changes in cTnT from normal (<0.01 microg/L, 8.4%) to small (> or =0.01 to <0.04 microg/L, 26%), moderate (> or =0.04 to <0.1 microg/L, 39%), and large (> or =0.1 microg/L, 47%) increases. Two-year mortalities were 30% for cTnI <0.1 microg/L and 52% if > or =0.1 microg/L. Univariate and adjusted relative risks of death associated with elevated (>99th percentile) cTnT were 5.0 (CI, 2.5 to 10; P<0.001) and 3.9 (CI, 1.9 to7.9; P<0.001) and cTnI were 2.0 (CI, 1.3 to 3.3; P=0.008) and 2.1 (CI, 1.3 to 3.3; P=0.007). Age, coronary artery disease, and time on dialysis were also independent predictors of mortality.Increases in cTnT and cTnI in ESRD patients show a 2- to 5-fold increase in mortality, with a greater number of patients having an increased cTnT.