High-Dose Cisplatin Therapy for Cancer for the Ovary: Neurotoxicity
Authors: CHARLES M. BAGLEY
Journal: Annals of Internal Medicine (1985)

Letters and Corrections1 May 1985High-Dose Cisplatin Therapy for Cancer for the Ovary: NeurotoxicityCHARLES M. BAGLEY JR., M.D., ROBERT H. RUDOLPH, M.D., SAUL E. RIVKIN, M.D., JOSEPH L. YON JR., M.D.CHARLES M. BAGLEY JR., M.D.Search for more papers by this author, ROBERT H. RUDOLPH, M.D.Search for more papers by this author, SAUL E. RIVKIN, M.D.Search for more papers by this author, JOSEPH L. YON JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-102-5-719 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We wish to call to your readers' attention an unexpectedly severe and disabling neurotoxicity due to very-high-dose cisplatin therapy for cancer of the ovary. The attainment of complete remission, proven by second-look surgery, is the first step toward achieving prolonged survival and cure of stage III cancer of the ovary. Recently, Ozols and associates (1) have reported that administration of very high doses of cisplatin (200 mg/m2 body surface area over 5 consecutive days) has achieved frequent tumor regression in patients with advanced cancer of the ovary previously refractory to conventional doses of cisplatin. To improve complete...Reference1. OZOLSCORDENJACOBWESLEYOSTCHEGAYOUNG RBJMYR. High-dose cisplatin in hypertonic saline. Ann Intern Med. 1984;100:19-24. LinkGoogle Scholar1. OZOLSCORDENJACOBWESLEYOSTCHEGAYOUNG RBJMYR. High-dose cisplatin in hypertonic saline. Ann Intern Med. 1984;100:19-24. LinkGoogle Scholar2. OZOLSIHDEJACOB RDJ. A randomized trial of PVeBV (high dose cisplatin, vinblastine, bleomycin, VP-16) vs. PVeB in poor prognosis non-seminomatous testicular cancer. Proc Am Assoc Clin Oncol. 1984;3:155. Google Scholar3. ROELOFSHRUSHESKYROGINROSENBERG RWJL. Peripheral sensory neuropathy and cisplatin chemotherapy. Neurology. 1984;34:934-8. CrossrefMedlineGoogle Scholar4. THOMPSONDAVISKORNFELDHILGERSSTANDELER SLMRJ. Cisplatin neuropathy: clinical, electrophysiologic, morphologic, and toxicologic studies. Cancer. 1984;54:1269-75. CrossrefMedlineGoogle Scholar5. OZOLSOSTCHEGACURTMYERSYOUNG RYGCR. High dose cisplatin (40 mg/M2 qd X 5) and high dose carboplatinum (CBDCA) (400 mg/M2 qd X 2) in refractory ovarian cancer: active salvage drugs with different toxicity. Proc Am Assoc Clin Oncol. 1985. (In press). Google Scholar6. YOUNGMYERSOSTCHEGAZABELLOZOLS RCYAR. CPR (cyclophosphamide high dose cisplatin and radiation): an aggressive short term induction regimen for advanced ovarian adenocarcinoma. Proc Am Assoc Clin Oncol. 1985. (In press). Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: CHARLES M. BAGLEYJR., M.D.; ROBERT H. RUDOLPH, M.D.; SAUL E. RIVKIN, M.D.; JOSEPH L. YONJR., M.D.Affiliations: Puget Sound Oncology Consortium Seattle, WA 98133 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNeurological complications of chemotherapy to the peripheral nervous systemCisplatin OverdoseClinical course and risk factors of neurotoxicity following cisplatin in an intensive dosing scheduleTreatment of non-small-cell lung cancer with vinblastine and very high-dose cisplatin. A Southwest Oncology Group studyEfficacy and safety of high-dose cisplatin and cyclophosphamide with glutathione protection in the treatment of bulky advanced epithelial ovarian cancerProspective study of nerve conduction parameters and serum magnesium following cisplatin therapyCisplatin neurotoxicityInadvertent administration of 480 mg/m2 of cisplatinHeavy Metal NeuropathiesEvolution of high-dose cisplatinProspective nerve conduction studies in cisplatin therapyCytostatics and immunosuppressive drugs 1 May 1985Volume 102, Issue 5Page: 719-719KeywordsBody surface areaOvarian cancerOvariesSurgery ePublished: 1 December 2008 Issue Published: 1 May 1985 PDF downloadLoading ...