tbuckley/cabot-search huggingface dataset:
Relationship of plasma BNP levels to tissue doppler and color M-mode indices of diastolic function and left ventricular filling pressure in systolic heart failure
Authors: Richard W. Troughton, David L. Prior, Jeremy J. Prior, Annette M. Fogarty, Maureen G. Martin, Timothy G. Yandle, Mark Richards, James D. Thomas, Allan L. Klein
Journal: Journal of the American College of Cardiology (2003)
Drug-induced thrombocytopenia: development of a novel NOD/SCID mouse model to evaluate clearance of circulating platelets by drug-dependent antibodies and the efficacy of IVIG
Authors: Simon X. Liang, Mykola Pinkevych, Levon M. Khachigian, Christopher R. Parish, Miles P. Davenport, Beng H. Chong
Journal: Blood (2010)
Medical Law for the Attending Physician: A Case-Oriented Analysis
Authors: David G. Warren
Journal: JAMA (1983)

Numerous heroic attempts have been made to brief physicians on the legal principles that affect their practices, ranging from heavy tomes on legal medicine to breezy videotapes. Most have met with serious problems inherent in the challenge: disciplinary gaps in terminology, complexity of legal process, and temptations to relate "bad doctor" or "worst possible results" examples and to engage in pedantic preaching. Coupled with too generous assumptions about physicians' attention spans, authors have generally failed to do more than frighten readers by the chapter headings: medical malpractice liability, patients' rights, public reporting responsibilities, and antitrust issues. Now there is a book that makes another valiant effort to bridge the chasm between lawyer's law and physician's law. Dr Fiscina, who is trained as both a physician and a lawyer, seems to have found a way to explain legal principles in medical language. By paraphrasing rather than merely editing the reported court
Pennsylvania and North Carolina State Board Examinations in 1904.
Authors: Seneca Egbert
Journal: JAMA (1905)

Philadelphia, June 6, 1905. <h3>To the Editor:</h3> —The results of the examinations for medical licenses for 1904, as published inThe Journal, May 6, have been very interesting to me, and I feel that I must commend you, both for their completeness and for the energy and labor expended in their preparation. There is, however, one point for criticism concerning them, inasmuch as it introduces an element of unfairness in the published reports and records of certain schools. I refer to the fact that in the report for Pennsylvania schools, and perhaps for those of some other states, certain individuals were counted twice in the summations, this being contrary, I believe, to established principles of statistical determination. Thus, for the Medico-Chirurgical College of Philadelphia, 78 members of the class of 1904 are reported as being examined, with 13 failures, the latter giving a percentage of 16.7. The fact is, no
Some New Pathological Concepts
Authors: Stanley L. Robbins
Journal: New England Journal of Medicine (1950)

PATENTLY it is impossible to review the entire subject of progress in pathology for the past few years. As in all fields of endeavor that have come of age, the further increments of knowledge that have been achieved in pathology have been concerned chiefly with expanding and correlating already existing knowledge. Thus, the past few years have seen no startling discoveries but rather detailed study and expansion of pre-existing observations. This communication attempts to indicate briefly some of the trends in the recent literature and then to consider in greater detail certain specific areas in which significant progress has recently . . .
Aging and arteriosclerosis. The increased proliferation of arterial smooth muscle cells isolated from old rats is associated with increased platelet-derived growth factor-like activity.
Authors: T A McCaffrey, A C Nicholson, P E Szabo, M E Weksler, B B Weksler
Journal: The Journal of Experimental Medicine (1988)

In vivo studies have suggested that the aorta from an old animal responds to injury with an exaggerated proliferation of smooth muscle cells (SMCs) compared with the response of this aorta from a young animal. In this study we compared proliferation of SMCs derived from uninjured old (less than 19 mo) and young (3-4 mo) rat aortas. Old SMCs grew more rapidly than young SMCs in the presence of medium containing competence factors (10% FCS or platelet-derived growth factor [PDGF]) as well as in their absence (2% PDS or serum-free media) as determined both by a short-term thymidine incorporation assay and by cell counts. Lysates prepared from old SMCs that had been grown in the absence of serum or PDGF stimulated proliferation of target cells more than lysates prepared from young SMCs; the effect was inversely related to cell density of the SMCs. This stimulatory effect of lysates was completely blocked by antibody to PDGF. After the growth-promoting activity of lysates was eliminated by anti-PDGF, growth-inhibiting activity was revealed. Lysates prepared from old SMCs had significantly less capacity to inhibit target cell growth. In the presence of exogenous heparin both the serum- or PDGF-stimulated proliferation and serum-free proliferation of old SMCs were decreased to the level of proliferation of young SMCs. These results suggest that the balance between growth-promoting and growth-inhibiting factors is altered in SMCs from old rats. This may contribute to the increased proliferative capacity of these cells in culture and may facilitate the development of atherosclerosis with age.
“Tight-Fitting Cloth”-Like Uptake of Ga-67 in a Patient With Psoriasis
Authors: Yung-Cheng Huang, Chien-Chin Hsu, Chia-Hui Hung, Hsiu-Hui Chiu
Journal: Clinical Nuclear Medicine (2009)

A 52-year-old man had a history of psoriasis vulgaris with regular follow-ups and medical treatment for more than 10 years. Because of his intermittent chills without fever, we performed a Ga-67 scan to evaluate the possibility of occult infection. The images showed evenly increased uptake, like a tight-fitting cloth, and delineated the outline of his body.
Life span of multipotential hematopoietic stem cells in vivo.
Authors: G Keller, R Snodgrass
Journal: The Journal of Experimental Medicine (1990)

The findings reported in this study highlight several important features of the development of hematopoietic stem cells after transplantation into irradiated recipients. First, they demonstrate the existence of a class of primitive multipotential stem cells that can function for a significant portion of the lifetime of a mouse (15 mo). In addition, they clearly show that these primitive stem cells can be infected with recombinant retroviruses and thus would be appropriate targets for gene therapy in somatic tissues. Second, our data indicate that the progeny of some, but not all, of the primitive stem cells have fully expanded into the various hematopoietic lineages by 2 mo after reconstitution. Finally, our analysis of the secondary recipients provides strong evidence suggesting that the primitive stem cell population can actually clonally expand. Our current experiments are aimed at determining the extent to which this expansion can occur and whether or not this expansion can be influenced by exogenous factors.
Recent advances: Paediatrics I: Infancy and early childhood
Authors: J. Pearn
Journal: BMJ (1997)

Children born in the last decade of the 20th century have been healthier, and will be longer lived, than ever before.1 Recent advances in paediatrics have seen national infant mortality rates fall below 5.0 per 1000 live births. The countries in which this has been achieved–Hong Kong, Taiwan, and Japan–have thus set benchmarks for the century ahead. In the context of world medicine, all who care for children rejoice in the momentum of advanced technology, which is saving hitherto unsavable individual children2 3; yet we are seeing the failings of delivery of health systems whose principles have been proved for decades. The major killers of the 13 million children who die annually before their fifth birthday4 remain pneumonia,5 gastroenteritis,4 malaria,6 measles,7 and trauma.8 The potentiating effects of malnutrition contribute to more than 80% of child deaths from infectious disease.9

One of the signal advances in paediatrics is the recognition that children's safety8 and health, indeed the very existence of whole races of children10 is a responsibility for all who practise in a contracting world.

### Mortality

Current best paediatric practice uses neonatal mortality rates specific to birth weight as a combined index of antenatal care and obstetric and paediatric care. In affluent countries these rates continue to fall and show no evidence of plateauing.1 The current United Kingdom neonatal death rate (deaths per 1000 live births in the first 28 days of life) for infants above the median birth weight of 3500 g is 0.9. The international benchmark for all infants who are not premature (those born weighing more than 2500 g) is a rate below 2.0 per 1000 live births.

The new treatments that have made this possible include the use of exogenous surfactant, high frequency ventilation, extracorporeal …
Cytohesin-1 controls the activation of RhoA and modulates integrin-dependent adhesion and migration of dendritic cells
Authors: Thomas Quast, Barbara Tappertzhofen, Cora Schild, Jessica Grell, Niklas Czeloth, Reinhold Förster, Ronen Alon, Line Fraemohs, Katrin Dreck, Christian Weber, Tim Lämmermann, Michael Sixt, Waldemar Kolanus
Journal: Blood (2009)
Role of neutrophils in myocardial stunning after brief ischaemia: the end of a six year old controversy (1987-1993)
Authors: R Bolli
Journal: Cardiovascular Research (1993)

Journal Article Role of neutrophils in myocardial stunning after brief ischaemia: the end of a six year old controversy (1987-1993) Get access R Bolli R Bolli Section of Cardiology Baylor College of Medicine 6535 Fannin, MS F-905 Houston, TX 77030 USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 27, Issue 5, May 1993, Pages 728–729, https://doi.org/10.1093/cvr/27.5.728 Published: 01 May 1993 Article history Received: 07 July 1992 Accepted: 28 October 1992 Published: 01 May 1993
Osteopathy, Chiropractic, and Spinal Manipulation
Authors: David S. Abend
Journal: Annals of Internal Medicine (1993)

Letters15 April 1993Osteopathy, Chiropractic, and Spinal ManipulationDavid S. Abend, MDDavid S. Abend, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-8-199304150-00028 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Shekelle and colleagues [1] under-represented the important contributions to spinal manipulation by the osteopathic medical profession. There are many osteopaths in the United States who use osteopathic manipulative treatment effectively in both the inpatient and outpatient settings. The data and methods in the review were heavily biased in favor of chiropractic care, omitting many important publications by and including osteopathic physicians [2-5]. Ironically, Andrew Taylor Still, MD, the founder of osteopathic medicine, discovered osteopathic manipulation and its holistic medical approach almost 20 years (1874) before chiropractic was discovered (1895), and D. D. Palmer, the founder of chiropractic, ...References1. Shekelle PG, Adams AH, Chassin MR, Hurwitz EL, Brook RH. Spinal manipulation for low-back pain. Ann Intern Med. 1992; 117:590-8. Google Scholar2. Bourdillon JF, Day EA. Spinal Manipulation. 4th edition. Norwalk, Connecticut: Appleton & Lange; 1987. Google Scholar3. Cantu RI, Grodin AJ. Myofascial Manipulation: Theory and Clinical Approach. Gaithersburg, Maryland: Aspen Publishers, Inc.; 1992. Google Scholar4. DiGiovanna EL, Schiowitz S. An Osteopathic Approach to Diagnosis and Treatment, Philadelphia: J.B. Lippincott Company; 1991. Google Scholar5. McMennell J. The Musculoskeletal System. Gaithersburg, Maryland: Aspen Publishers; 1992. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 April 1993Volume 118, Issue 8Page: 651-653KeywordsChiropracticDrug therapyExerciseExercise therapyInpatientsLibrariesMuscular dystrophiesOsteopathyOutpatients Issue Published: 15 April 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Intensive care for children
Authors: J Palmer, B L Taylor, G B Smith, P Fulbrook
Journal: BMJ (1994)

EDITOR, - We support the call for improved national paediatric intensive care services1 and the principles outlined in the British Paediatric Association's document2; however, the method of achieving this should not be oversimplified. As Shann observes, a substantial number of children receieve no intensive care,3 emphasising the failure of many to appreciate the benefits of early referral to intensive care units. Increasing the number of paediatric intensive care beds will not resolve this issue unless an increase is linked to …
Randomized Controlled Trial of Domiciliary Noninvasive Positive Pressure Ventilation and Physical Training in Severe Chronic Obstructive Pulmonary Disease
Authors: RACHEL GARROD, CHRISTINE MIKELSONS, ELIZABETH A. PAUL, JADWIGA A. WEDZICHA
Journal: American Journal of Respiratory and Critical Care Medicine (2000)

The addition of noninvasive positive pressure ventilation (NPPV) to an exercise training (ET) program in severe chronic obstructive pulmonary disease (COPD) may produce greater benefits in exercise tolerance and quality of life than after training alone. Forty-five patients with severe stable COPD—mean (SD) FEV1 0.96 (0.31) L, PaO2 65.4 (9.07) mm Hg, PaCO2 45.6 (7.89) mm Hg—were randomized to domiciliary NPPV + ET (n = 23) or ET alone (n = 22). Exercise capacity and health status were assessed at baseline and after an 8-wk training program. There was a significant improvement in mean shuttle walk test (SWT) in the NPPV + ET group: from 169 (112) to 269 (124) m (p = 0.001), compared with the ET group: 205 (100) to 233 (123) m (p = 0.19); mean difference (95% confidence interval [CI]): 72 (12.9 to 131) m. Repeated measures analysis of variance (ANOVA) showed that the differences between the two groups became evident only in the final 4 wk of the training program with a mean end study difference (95% 1CI) of 65.8 (17.1 to 114) m. There was a significant improvement in the Chronic Respiratory Disease Questionnaire (CRDQ) of mean (SD) 24.0 (17.4) (p = < 0.001) in the NPPV + ET group and 11.8 (15.8) (p = 0.003) points in the ET group; mean difference: 12.3 (1.19 to 23.4). Only the NPPV + ET group demonstrated a significant improvement in arterial oxygenation; mean difference: 3.70 mm Hg (0.37 to 7.27). This study suggests that domiciliary NPPV can be used successfully to augment the effects of rehabilitation in severe COPD.
Abstract 4886: Investigation of cytoskeletal dynamics in real-time during carcinoma cell migration and invasion <i>in vitro</i>
Authors: Carolyn G. Conant, Michael Schwartz, Cristian Ionescu-Zanetti
Journal: Cancer Research (2011)

Abstract Understanding the fine details of events leading to the establishment of secondary metastatic foci is complicated by methods that are either endpoint or in vivo. We have devised a unique method to investigate real-time events of cell migration and invasion in vitro. We utilized laminar flow cells with a two-inlet geometry to create compartments of either matrigel or chemotactic stimuli. We then introduced carcinoma cells (HT1080) into opposing neutral compartments and imaged the real-time events associated with cell motility. Use of transient transduction of actin-GFP, the myristolyation/palmitoylation sequence from Lck tyrosine kinase-CFP (MPS) and SV40 nuclear-localization sequence-RFP (BacMam) allowed live investigation of cell motility during chemotaxis and invasion. We found that membrane ruffling occurred within minutes of cell adhesion in the neutral compartment. Chemotaxis and invasion occurred within 4 hours of cell introduction, concurrent with massive and dynamic cytoskeletal reorganization. Migration and cell proliferation continued for the entire duration of the data capture up to 24-hours. This method is further extensible to understanding detailed information regarding signaling, inhibition and fluid dynamics on processes of metastatic cell travel through the vasculature, cell adhesion and extravasation. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4886. doi:10.1158/1538-7445.AM2011-4886
Immunological studies on Behcet's syndrome.
Authors: T Shimizu, Y Katsuta, Y Oshima
Journal: Annals of the Rheumatic Diseases (1965)

Summarized results of the clinical and laboratory findings in 85 cases of Beh9et's syndrome seen at our clinic between September, 1957, and April, 1961, have already been reported (Oshima, Shimizu, Yokohari, Matsumoto, Kano, Kagami, and Nagaya, 1963).Investigation revealed a high incidence of abnormalities, not only in the mouth, eyes, and genital organs, but also in the intestine, cerebrospinal fluid, and plasma proteins.A homologous antibody against human oral mucous membrane tested by the tanned-cell haemagglutination technique proved positive in seventeen of forty cases of Behqet's syndrome and the titre changed along with the clinical course of the disease, though it proved negative in eighteen healthy controls.These data suggest that the disease must be systemic.More- over, recurrence of the multiple manifestations characterizes the clinical picture of Behqet's syn- drome (Mavioglu, 1958; Strachan and Wigzell, 1963; Shimizu, Kagami, Matsumoto, and Matsumura, 1963).No causative micro-organism was found in spite of fever, general malaise, and the progressive course of the disease.These findings suggest that an autoimmune mechanism may be concerned in the pathogenesis and development of these characteristic recurrent clinical features.The present investigation deals mainly with immunological studies on our cases of Beh9et's syndrome. Material and Methods132 subjects seen at our clinic between September, 1957, and March, 1964, comprised 85 males and 47
The third generation pill controversy ("continued")
Authors: J O Drife
Journal: BMJ (2001)

Papers p 131 

The debate about the safety of third generation oral contraceptives shows no sign of fading away. Since it began in 1995 the main participants have been epidemiologists and clinical pharmacologists. There has been little input from the clinicians who prescribe oral contraceptives or from the women who use them.

About 80% of British women use the pill at some time between the ages of 16 and 24.1 It was this age group that paid the price of the October 1995 scare, prompted by the publicity surrounding the announcement of the Committee on Safety of Medicines that third generation oral contraceptives had a higher risk of inducing venous thromboembolism. In the first quarter of 1996 in England and Wales there were 6198 more abortions than in the previous quarter (a 16% rise), and the increase continued more slowly until 1998.2 Doctors who counsel women with unplanned pregnancy are still angry about the amount of human misery caused by information mismanagement.

The 1995 scare arose from three studies that reported that the risk of venous thromboembolism among users of pills containing levonorgestrel was half that of pills containing desogestrel or gestodene—the so called “third generation” progestogens. Over the following five years, …
Isolated Right Ventricular Infarction
Authors: David M. Zientek, Carl E. Eybel
Journal: Annals of Internal Medicine (1993)

Letters15 November 1993Isolated Right Ventricular InfarctionDavid M. Zientek, MD and Carl E. Eybel, MDDavid M. Zientek, MDSearch for more papers by this author and Carl E. Eybel, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-10-199311150-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Kahn and colleagues [1] described two patients with isolated right ventricular infarction due to a lesion in a nondominant right coronary artery who were treated with angioplasty. Both presented with normal 12-lead electrocardiograms, although the second developed atrial fibrillation.We previously described a similar patient who presented with atrial fibrillation and isolated ST-segment elevation in lead V1 with inferolateral ST depression [2]. Isolated right ventricular infarction was confirmed by creatine kinase elevation, echocardiography, and right-heart catheterization. Post-infarction angina led to cardiac catheterization, which showed a codominant circulation with an anomalous right coronary artery arising from the left ...References1. Kahn JK, Bernstein M, Bengston Jr. Isolated right ventricular myocardial infarction. Ann Intern Med. 1993; 118:708-11. Google Scholar2. Zientek DM, Eybel CE. Isolated right ventricular infarction: Unusual presentation and PTCA of culprit lesion in anomalous right coronary artery. J Invas Cardiol. 1992; 4:479-82. Google Scholar3. Mittal SR, Pamecha S, Rohatgi R, Saxena R, Gokhroo R. Isolated right ventricular infarction. Int J Cardiol. 1992; 36:187-96. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 November 1993Volume 119, Issue 10Page: 1053KeywordsAngioplastyAtrial fibrillationCatheterizationEchocardiographyElectrocardiographyInfarctionLesionsPatient advocacyRight coronary arteryStenosis Issue Published: 15 November 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Biliary Complications of Gallstone Lithotripsy Detected by Tc-99m DISIDA Scintigraphy
Authors: JAMES K. St. GEORGE, MICHAEL G. VELCHIK
Journal: Clinical Nuclear Medicine (1991)

Extracorporeal shock wave lithotripsy (ESWL) has been reported to be a safe and relatively effective non-invasive treatment for radiolucent gallbladder calculi in selected patients. Ideally, the goal of successful treatment is the passage of all fragments from the gallbladder into the intestinal tract. Biliary colic has been reported in up to 35% of treated patients, although complications such as cholecystitis, cholangitis, common bile duct obstruction, and pancreatitis are surprisingly infrequent. Cholescintigraphy is the procedure of choice in patients with biliary colic and suspected acute cholecystitis. It has proven to be more sensitive than ultrasound in detecting acute common bile duct (CBD) obstruction, since functional obstruction precedes morphologic dilatation of the.CBD. This report reviews two cases of post-lithotripsy cystic and common duct obstruction and discusses the role of Tc-DISIDA scintigraphy following gallstone ESWL.
Government to increase number of GPs and emergency medicine doctors
Authors: H. Jaques
Journal: BMJ (2013)

The number of general practitioner (GP) training places in England will be increased by 14% and more doctors will be encouraged to enter emergency medicine, under plans announced by the government.

The Department of Health has set out its expectations for Health Education England in a mandate for the organisation.1 Health Education England took responsibility for healthcare education and workforce planning in April. 

The Department of Health stipulates that Health Education England should ensure that 50% of medical students become GPs. At present, there are 2850 training posts …