tbuckley/cabot-search huggingface dataset:
Quality assessment and predictors of survival in long-term domiciliary oxygen therapy. The Swedish Society of Chest Medicine
Authors: K Strom, J Boe
Journal: European Respiratory Journal (1991)

On January 1, 1987, 560 patients (267 male) were registered as using long-term domiciliary oxygen therapy (LTO) in Sweden. The duration of LTO before this date varied between 10 days and 11 yrs. During a two-year follow-up 12 patients had their LTO withdrawn because they were no longer hypoxic. In 139 patients the arterial oxygen tension (PaO2) on breathing air was registered three times. In seventeen (12%) of these patients the PaO2 exceeded 7.5 kPa on all three control occasions. The two year actuarial survival in all patients was 57%. The two year actuarial survival was 77% in patients with kyphoscoliosis, 56% in patients with sequelae of tuberculosis, 54% in patients with chronic obstructive pulmonary disease (COPD) and 39% in patients with fibrosis. In COPD patients survival was predicted by age, sex, current smoking habits, arterial carbon dioxide tension (PacO2) when breathing oxygen and oral steroid medication. A poor Zubrod performance score was associated with a high mortality rate in all patient groups.
Near-Infrared Fluorescent Imaging of Matrix Metalloproteinase Activity After Myocardial Infarction
Authors: Jiqiu Chen, Ching-Hsuan Tung, Jennifer R. Allport, Si Chen, Ralph Weissleder, Paul L. Huang
Journal: Circulation (2005)

Background— We used a molecular probe activated by protease cleavage to image expression of matrix metalloproteinases (MMPs) in the heart after myocardial infarction. Methods and Results— We synthesized and characterized a near-infrared fluorescent (NIRF) probe that is activated by proteolytic cleavage by MMP2 and MMP9. The NIRF probe was injected into mice at various time points up to 4 weeks after myocardial infarction induced by ligation of the left anterior descending coronary artery. NIRF imaging of MMP activity increased in the infarct region, with maximal expression at 1 to 2 weeks, persisting to 4 weeks. Zymography and real-time polymerase chain reaction analysis showed that MMP9 expression is increased at 2 to 4 days, and MMP2 expression is increased at 1 to 2 weeks. Dual-label confocal microscopy showed colocalization of NIRF imaging with neutrophils on day 2, and flow cytometric analysis confirmed that NIRF signal is associated with leukocytes in the infarct zone. Conclusions— This study demonstrates that the activity of MMPs in the myocardium may be imaged by use of specific activity–dependent molecular probes.
Transmission of Murine Leukemia Virus (Scripps) From Parent to Progeny Mice: A Comparison of Assay Systems23
Authors: A. Bennett Jenson, Dennis E. Groff, Patricia J. McConahey, Frank J. Dixon
Journal: JNCI Journal of the National Cancer Institute (1976)

Journal Article Transmission of Murine Leukemia Virus (Scripps) From Parent to Progeny Mice: A Comparison of Assay Systems Get access A. Bennett Jenson, A. Bennett Jenson Search for other works by this author on: Oxford Academic PubMed Google Scholar Dennis E. Groff, Dennis E. Groff Search for other works by this author on: Oxford Academic PubMed Google Scholar Patricia J. McConahey, Patricia J. McConahey Search for other works by this author on: Oxford Academic PubMed Google Scholar Frank J. Dixon Frank J. Dixon 8 7Address reprint requests to Dr. Dixon. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 57, Issue 2, August 1976, Pages 421–424, https://doi.org/10.1093/jnci/57.2.421 Published: 01 August 1976 Article history Received: 08 January 1976 Accepted: 17 February 1976 Published: 01 August 1976
Portal Pressure Predicts Outcome and Safety of Antiviral Therapy in Cirrhotic Patients With Hepatitis C Virus Infection
Authors: Thomas Reiberger, Karoline Rutter, Arnulf Ferlitsch, Berit Anna Payer, Harald Hofer, Sandra Beinhardt, Michael Kundi, Peter Ferenci, Alfred Gangl, Michael Trauner, Markus Peck–Radosavljevic
Journal: Clinical Gastroenterology and Hepatology (2011)
Trichilemmal horn: cutaneous horn showing trichilemmal keratinization
Authors: MARTIN H. BROWNSTEIN
Journal: British Journal of Dermatology (1979)

A unique and distinctive clinicopathological entity occurred in nineteen patients who ranged in age from 16 to 72 (median 50) years. Clinically, these were solitary cutaneous horns. Nine were on the limbs, four on the back, two on the face, three on the scalp, and in one the site was not known; the median duration was 2 years. Histologically, there was a benign picture with a protrusion of massive horn and trichilemmal keratinization at the base. This tumour, which I have named trichilemmal horn, must be differentiated from other lesions that show trichilemmal keratinization (trichilemmal cyst, proliferating trichilemmal cyst, keratoacanthoma) and from other cutaneous horns, including trichilemmomal horn (cutaneous horn overlying trichilemmoma).
Expression of the <i>EWS/FLI-1</i> Oncogene in Murine Primary Bone-Derived Cells Results in EWS/FLI-1–Dependent, Ewing Sarcoma–Like Tumors
Authors: Yeny Castillero-Trejo, Susan Eliazer, Lilin Xiang, James A. Richardson, Robert L. Ilaria
Journal: Cancer Research (2005)

Abstract Ewing sarcoma is the second most common malignant pediatric bone tumor. Over 80% of Ewing sarcoma contain the oncogene EWS/FLI-1, which encodes the EWS/FLI-1 oncoprotein, a hybrid transcription factor comprised of NH2-terminal sequences from the RNA-binding protein EWS and the DNA-binding and COOH-terminal regions of the Ets transcription factor FLI-1. Although numerous genes are dysregulated by EWS/FLI-1, advances in Ewing sarcoma cancer biology have been hindered by the lack of an animal model because of EWS/FLI-1–mediated cytotoxicity. In this study, we have developed conditions for the isolation and propagation of murine primary bone-derived cells (mPBDC) that stably express EWS/FLI-1. Early-passage EWS/FLI-1 mPBDCs were immortalized in culture but inefficient at tumor induction, whereas later-passage cells formed sarcomatous tumors in immunocompetent syngeneic mice. Murine EWS/FLI-1 tumors contained morphologically primitive cells that lacked definitive lineage markers. Molecular characterization of murine EWS/FLI-1 tumors revealed that some but not all had acquired a novel, clonal in-frame p53 mutation associated with a constitutive loss of p21 expression. Despite indications that secondary events facilitated EWS/FLI-1 mPBDC tumorigenesis, cells remained highly dependent on EWS/FLI-1 for efficient transformation in clonogenic assays. This Ewing sarcoma animal model will be a useful tool for dissecting the molecular pathogenesis of Ewing sarcoma and provides rationale for the broader use of organ-specific progenitor cell populations for the study of human sarcoma.
A clutch of new syndromes?
Authors: J. Le Fanu
Journal: Journal of the Royal Society of Medicine (2002)

It is reasonable to infer—given the accuracy and sophistication of modern diagnostic techniques—that those patients whose symptoms remain unexplained despite specialist investigation have a somatoform disorder1. Indeed such an inference may be obligatory, since protracted rounds of investigative procedures are expensive and can be harmful, while appropriate psychiatric or psychotherapeutic treatment is effective2,3. Nonetheless, general practitioners in particular recognize that definitive diagnosis can remain elusive in patients whose symptoms point strongly to organic disease. Their symptomatology can be distinguished from the somatoform disorders on the grounds of specificity and consistency: the same symptom complex is described, often in considerable detail, over a long period with little or no variation.

So far there has been no systematic study of these difficult-to-diagnose syndromes, so their pattern and prevalence remains unknown. I describe here a series of ‘mystery’ syndromes, as reported by readers of a national daily paper over 2 years, as a possible basis for further investigation of this important and neglected issue.
Neovascularization of ischemic tissues by gene delivery of the extracellular matrix protein Del-1
Authors: Jingping Zhong, Brian Eliceiri, Dwayne Stupack, Kalyani Penta, Gordon Sakamoto, Thomas Quertermous, Mike Coleman, Nancy Boudreau, Judith A. Varner
Journal: Journal of Clinical Investigation (2003)

The ECM protein Del-1 is one of several novel ECM proteins that accumulate around angiogenic blood vessels in embryonic and tumor tissue and promote angiogenesis in the absence of exogenous growth factors. Del-1 expressed in mouse or rabbit ischemic hind-limb muscle by gene transfer rapidly promotes new blood vessel formation and restores muscle function. This angiogenic ECM protein initiates angiogenesis by binding to integrin αvβ5 on resting endothelium, thereby resulting in expression of the transcription factor Hox D3 and integrin αvβ3. Hox D3 converts resting endothelium to angiogenic endothelium by inducing expression of proangiogenic molecules such as integrin αvβ3. These findings provide evidence for an angiogenic switch that can be initiated in the absence of exogenous growth factors and indicate that the angiogenic matrix protein Del-1 may be a useful tool for the therapy of ischemic disease.
Best Practices in Robot-assisted Radical Prostatectomy: Recommendations of the Pasadena Consensus Panel
Authors: Francesco Montorsi, Timothy G. Wilson, Raymond C. Rosen, Thomas E. Ahlering, Walter Artibani, Peter R. Carroll, Anthony Costello, James A. Eastham, Vincenzo Ficarra, Giorgio Guazzoni, Mani Menon, Giacomo Novara, Vipul R. Patel, Jens-Uwe Stolzenburg, Henk Van der Poel, Hein Van Poppel, Alexandre Mottrie
Journal: European Urology (2012)
INHIBITION OF URINE CITRATE EXCRETION AND THE PRODUCTION OF RENAL CALCINOSIS IN THE RAT BY ACETAZOLEAMIDE (DIAMOX®) ADMINISTRATION 1
Authors: Harold E. Harrison, Helen C. Harrison
Journal: Journal of Clinical Investigation (1955)

We have previously observed that the urinary excretion of citrate is reduced to low levels in rats treated with the carbonic anhydrase inhibitor, acetazoleamide (Diamox®g) (1).This first ex- periment was prompted by the fact that the ele- vated serum chloride and decreased serum bicar-.bonate concentrations, and the fixation of the urine pH at approximately 7 or above following administration of an agent which inhibits carbonic anhydrase activity resembles the findings in pa- tients with congenital renal tubular acidosis.In a study of an infant with this syndrome we found that the urinary excretion of citrate was too low to be measured (1).The absence of citrate in the urine of this patient persisted even after the hyperchloremia and acidosis were corrected by ad- ministration of 40 mM of sodium lactate daily and the urine pH was raised to about 8.0.This is in contrast to the findings in normal subjects in whom the renal excretion of citrate increases when the urine is made alkaline by administration of sodium or potassium bicarbonate or the sodium and po- tassium salts of organic acids (2).It has also TABLE I Composition of diets (basic diet) gm.
An Epidemic of<i>Malassezia pachydermatis</i>in an Intensive Care Nursery Associated with Colonization of Health Care Workers' Pet Dogs
Authors: Huan J. Chang, Hilary L. Miller, Nancy Watkins, Matthew J. Arduino, David A. Ashford, Gillian Midgley, Sonia M. Aguero, Roshini Pinto-Powell, C. Fordham von Reyn, William Edwards, Michael M. McNeil, William R. Jarvis, Ruth Pruitt
Journal: New England Journal of Medicine (1998)

Malassezia species are lipophilic yeasts that are emerging as nosocomial pathogens, particularly in low-birth-weight neonates who receive lipid emulsions. When a cluster of patients with Malassezia pachydermatis infection was identified in an intensive care nursery, we initiated an investigation.A case patient was defined as any infant in the intensive care nursery who had a positive culture for M. pachydermatis between October 17, 1993, and January 18, 1995. We conducted a cohort study to identify risk factors for colonization and infection with M. pachydermatis. We collected cultures from the infants and the health care workers and from the health care workers' pets, since this organism has been associated with otitis externa in dogs.Fifteen infants met the case definition: eight with bloodstream infections, two with urinary tract infections, one with meningitis, and four with asymptomatic colonization. The case patients were significantly more likely than the other infants to weigh 1300 g or less (15 of 65 vs. 0 of 419, P<0.001). In a multivariate analysis of infants weighing 1300 g or less, the independent risk factors for colonization or infection with M. pachydermatis were a greater severity of concomitant illness (odds ratio, 19.7; P=0.001), arterial catheterization for nine or more days (odds ratio, 29.5; P=0.027), and exposure to Nurse A (odds ratio, 74.7; P=0.004). In a point-prevalence survey, 9 additional infants, 1 health care worker, and 12 of the health care workers' pet dogs had positive cultures for M. pachydermatis. The isolates from all 15 case patients, the 9 additional colonized infants, 1 health care worker, and 3 of the 12 dogs had identical patterns of restriction-fragment-length polymorphisms.In this outbreak, it is likely that M. pachydermatis was introduced into the intensive care nursery on health care workers' hands after being colonized from pet dogs at home. The organism persisted in the nursery through patient-to-patient transmission.
Regulation of lymph node vascular growth by dendritic cells
Authors: Brian Webster, Eric H. Ekland, Lucila M. Agle, Susan Chyou, Regina Ruggieri, Theresa T. Lu
Journal: The Journal of Experimental Medicine (2006)

Lymph nodes grow rapidly and robustly at the initiation of an immune response, and this growth is accompanied by growth of the blood vessels. Although the vessels are critical for supplying nutrients and for controlling cell trafficking, the regulation of lymph node vascular growth is not well understood. We show that lymph node endothelial cells begin to proliferate within 2 d of immunization and undergo a corresponding expansion in cell numbers. Endothelial cell proliferation is dependent on CD11c+ dendritic cells (DCs), and the subcutaneous injection of DCs is sufficient to trigger endothelial cell proliferation and growth. Lymph node endothelial cell proliferation is dependent on vascular endothelial growth factor (VEGF), and DCs are associated with increased lymph node VEGF levels. DC-induced endothelial cell proliferation and increased VEGF levels are mediated by DC-induced recruitment of blood-borne cells. Vascular growth in the draining lymph node includes the growth of high endothelial venule endothelial cells and is functionally associated with increased cell entry into the lymph node. Collectively, our results suggest a scenario whereby endothelial cell expansion in the draining lymph node is induced by DCs as part of a program that optimizes the microenvironment for the ensuing immune response.
The forced oscillation technique in clinical practice: methodology, recommendations and future developments
Authors: E. Oostveen, D. MacLeod, H. Lorino, R. Farré, Z. Hantos, K. Desager, F. Marchal
Journal: European Respiratory Journal (2003)

The forced oscillation technique (FOT) is a noninvasive method with which to measure respiratory mechanics. FOT employs small-amplitude pressure oscillations superimposed on the normal breathing and therefore has the advantage over conventional lung function techniques that it does not require the performance of respiratory manoeuvres. The present European Respiratory Society Task Force Report describes the basic principle of the technique and gives guidelines for the application and interpretation of FOT as a routine lung function test in the clinical setting, for both adult and paediatric populations. FOT data, especially those measured at the lower frequencies, are sensitive to airway obstruction, but do not discriminate between obstructive and restrictive lung disorders. There is no consensus regarding the sensitivity of FOT for bronchodilation testing in adults. Values of respiratory resistance have proved sensitive to bronchodilation in children, although the reported cutoff levels remain to be confirmed in future studies. Forced oscillation technique is a reliable method in the assessment of bronchial hyperresponsiveness in adults and children. Moreover, in contrast with spirometry where a deep inspiration is needed, forced oscillation technique does not modify the airway smooth muscle tone. Forced oscillation technique has been shown to be as sensitive as spirometry in detecting impairments of lung function due to smoking or exposure to occupational hazards. Together with the minimal requirement for the subject's cooperation, this makes forced oscillation technique an ideal lung function test for epidemiological and field studies. Novel applications of forced oscillation technique in the clinical setting include the monitoring of respiratory mechanics during mechanical ventilation and sleep.
MicroRNA Expression and Clinical Outcomes in Patients Treated with Adjuvant Chemotherapy after Complete Resection of Non–Small Cell Lung Carcinoma
Authors: Johannes Voortman, Akiteru Goto, Jean Mendiboure, Jane J. Sohn, Aaron J. Schetter, Motonobu Saito, Ariane Dunant, Trung C. Pham, Iacopo Petrini, Alan Lee, Mohammed A. Khan, Pierre Hainaut, Jean-Pierre Pignon, Elisabeth Brambilla, Helmut H. Popper, Martin Filipits, Curtis C. Harris, Giuseppe Giaccone
Journal: Cancer Research (2010)

This study determined whether expression levels of a panel of biologically relevant microRNAs can be used as prognostic or predictive biomarkers in patients who participated in the International Adjuvant Lung Cancer Trial (IALT), the largest randomized study conducted to date of adjuvant chemotherapy in patients with radically resected non-small cell lung carcinoma (NSCLC). Expression of miR-21, miR-29b, miR-34a/b/c, miR-155, and let-7a was determined by quantitative real-time PCR in formalin-fixed paraffin-embedded tumor specimens from 639 IALT patients. The prognostic and predictive values of microRNA expression for survival were studied using a Cox model, which included every factor used in the stratified randomization, clinicopathologic prognostic factors, and other factors statistically related to microRNA expression. Investigation of the expression pattern of microRNAs in situ was performed. We also analyzed the association of TP53 mutation status and miR-34a/b/c expression, epidermal growth factor receptor and KRAS mutation status, and miR-21 and Let-7a expression. Finally, the association of p16 and miR-29b expression was assessed. Overall, no significant association was found between any of the tested microRNAs and survival, with the exception of miR-21 for which a deleterious prognostic effect of lowered expression was suggested. Otherwise, no single or combinatorial microRNA expression profile predicted response to adjuvant cisplatin-based chemotherapy. Together, our results indicate that the microRNA expression patterns examined were neither predictive nor prognostic in a large patient cohort with radically resected NSCLC, randomized to receive adjuvant cisplatin-based chemotherapy versus follow-up only.
Ligand-Dependent Cleavage of the P75 Neurotrophin Receptor Is Necessary for NRIF Nuclear Translocation and Apoptosis in Sympathetic Neurons
Authors: Rajappa S. Kenchappa, Niccolò Zampieri, Moses V. Chao, Philip A. Barker, Henry K. Teng, Barbara L. Hempstead, Bruce D. Carter
Journal: Neuron (2006)
Plasmacytoid dendritic cell depletion in DOCK8 deficiency: Rescue of severe herpetic infections with IFN-α 2b therapy
Authors: Sevgi Keles, Haifa H. Jabara, Ismail Reisli, Douglas R. McDonald, Isil Barlan, Rima Hanna-Wakim, Ghassan Dbaibo, Gerard Lefranc, Waleed Al-Herz, Raif S. Geha, Talal A. Chatila
Journal: Journal of Allergy and Clinical Immunology (2014)
Structure and function of endometrial blood vessels
Authors: P. Rogers
Journal: Human Reproduction Update (1996)

The endometrial blood vessels form a vascular bed with a number of unusual properties. Unlike most adult vasculature these blood vessels undergo constant cycles of growth and regression during the reproductive life of the female. This short review covers a number of different aspects relating to endometrial vascular structure and function during endometrial growth, implantation, endometrial regression and menstruation. Video footage from in-vivo microscopy of the rat endometrial subepithelial capillary plexus on the morning of day 6 of pregnancy is included in the CD-ROM. This shows the dramatic changes that occur to the endometrial capillaries at the time of embryo implantation. Keywords: angiogenesis/blood vessel/endometrium/implantation/menstruation
Control of Cardiac Hypertrophy and Fibrosis by the Notch Pathway
Authors: Mohamed Nemir, Melanie Metrich, Isabelle Plaisance, Mario Lepore, Corinne Berthonneche, Alexandre Sarre, Freddy Radtke, Thierry Pedrazzini
Journal: Circulation (2011)

Keywords: Signal transduction ; Cardiac regeneration ; Hypertrophy ; Fibrosis ; Transgenic models Reference EPFL-CONF-178480View record in Web of Science Record created on 2012-06-25, modified on 2017-05-12
A RENAL ABNORMALITY AS A POSSIBLE CAUSE OF "ESSENTIAL" HYPERTENSION
Authors: G Bianchi, M Gatti, P Ferrari, G.B Picotti, G Colombo, O Velis, D Cusi, G.P Lupi, C Barlassina, G Bracchi, D Gori, D Mazzei, G Colombo, D Gori, O Velis, D Mazzei
Journal: The Lancet (1979)
Rituximab therapy for chronic periaortitis
Authors: Federica Maritati, Domenico Corradi, Annibale Versari, Massimiliano Casali, Maria Letizia Urban, Carlo Buzio, Augusto Vaglio
Journal: Annals of the Rheumatic Diseases (2012)

Chronic periaortitis (CP) is a rare condition, hallmarked by periaortic fibro-inflammatory tissue which often causes ureteral obstruction, and encompasses idiopathic retroperitoneal fibrosis and inflammatory abdominal aortic aneurysm (IAAA). CP usually responds to glucocorticoids, but some patients may be steroid-refractory or not tolerate standard glucocorticoid doses. For such cases, valid therapeutic alternatives are lacking.1 2 Combinations of prednisone and immunosuppressants (eg, cyclophosphamide, mycophenolate mofetil) are not of proven superiority to prednisone alone, and their effectiveness in refractory CP is unknown.3 4 Because B cells abundantly infiltrate CP lesions,5 and CP is often associated with autoimmune diseases,6 we used rituximab in two patients with CP, one refractory to conventional treatments, and the other with contraindications to standard-dose glucocorticoids.

Our first patient, a 49-year-old woman, was hospitalised for malaise and back pain. Abdominal CT revealed a soft-tissue-density periaortic mass suggesting CP, a diagnosis confirmed by laparoscopic biopsy (figure 1). The patient responded to prednisone (initial dose, 1 mg/kg/day), with symptom remission and reduction in CP thickness, but relapsed with back pain and CP enlargement when the prednisone dose was 5 mg/day (8 months after treatment initiation). …
TOWNE-VACCINE-INDUCED PREVENTION OF CYTOMEGALOVIRUS DISEASE AFTER RENAL TRANSPLANTS
Authors: StanleyA. Plotkin, HarveyM. Friedman, GaryR. Fleisher, DonaldC. Dafoe, RobertA. Grossman, M. Lynn Smiley, StuartE. Starr, Cliff Wlodaver, AllanD. Friedman, ClydeF. Barker
Journal: The Lancet (1984)