tbuckley/cabot-search huggingface dataset:
Low value of simple echocardiographic indices of ventricular dyssynchrony in predicting the response to cardiac resynchronization therapy
Authors: Pierre Bordachar, Stéphane Lafitte, Patricia Réant, Sylvain Reuter, Jacques Clementy, Ralph‐Uwe Mletzko, Robert M. Siegel, Kinga Goscinska‐Bis, Robert Bowes, John Morgan, Sandrine Bénard, Christophe Leclercq
Journal: European Journal of Heart Failure (2010)
Comparative Effects of Insulin on Adipose Tissue Segments and Isolated Fat Cells of Rat and Man*
Authors: F. Arnold Gries, Jürgen Steinke
Journal: Journal of Clinical Investigation (1967)

In vitro metabolism of glucose-1-(14)C by adipose tissue into (14)CO(2) and total (14)C lipids in rat and man was compared employing both adipose tissue segments and isolated fat cells prepared from the same donor. In the rat, the basal glucose metabolism and response to insulin decreased with increasing body weight for both adipose tissue segments and isolated cells. Regardless of age, the isolated cells exhibited a persistently higher metabolic activity. Of the parameters selected, conversion to CO(2) was more pronounced than that to lipid.In contrast to the rat, in man adipose tissue segments were more active than isolated cells. In four subjects, the effect of 6, 50, and 400 muU/ml of insulin was analyzed on conversion of glucose-1-carbon to CO(2), long chain fatty acids, and glycerides by adipose tissue segments only. In 17 subjects, glucose oxidation and lipid synthesis by adipose tissue segments and isolated fat cells were measured and showed a definite response to physiological doses of crystalline pork insulin. There was, however, an age dependency, and consistent effects were obtained with 6 muU/ml in children and 50 muU/ml in adults. The responsiveness of human adipose tissue to exogenous insulin in concentrations comparable to those detected in blood reemphasizes the importance of adipose tissue as a major site for fatty acid synthesis.
On the functions of the h subunit of eukaryotic initiation factor 3 in late stages of translation initiation
Authors: Byung-Hoon Kim, Xue Cai, Justin N Vaughn, Albrecht G von Arnim
Journal: Genome biology (2007)

The eukaryotic translation initiation factor 3 (eIF3) has multiple roles during the initiation of translation of cytoplasmic mRNAs. How individual subunits of eIF3 contribute to the translation of specific mRNAs remains poorly understood, however. This is true in particular for those subunits that are not conserved in budding yeast, such as eIF3h.Working with stable reporter transgenes in Arabidopsis thaliana mutants, it was demonstrated that the h subunit of eIF3 contributes to the efficient translation initiation of mRNAs harboring upstream open reading frames (uORFs) in their 5' leader sequence. uORFs, which can function as devices for translational regulation, are present in over 30% of Arabidopsis mRNAs, and are enriched among mRNAs for transcriptional regulators and protein modifying enzymes. Microarray comparisons of polysome loading in wild-type and eif3h mutant seedlings revealed that eIF3h generally helps to maintain efficient polysome loading of mRNAs harboring multiple uORFs. In addition, however, eIF3h also boosted the polysome loading of mRNAs with long leaders or coding sequences. Moreover, the relative polysome loading of certain functional groups of mRNAs, including ribosomal proteins, was actually increased in the eif3h mutant, suggesting that regulons of translational control can be revealed by mutations in generic translation initiation factors.The intact eIF3h protein contributes to efficient translation initiation on 5' leader sequences harboring multiple uORFs, although mRNA features independent of uORFs are also implicated.
Abstract 5032: Targeting Src in mucinous ovarian carcinoma
Authors: Koji Matsuo, Masato Nishimura, Rebbeca L. Stone, Kakajan Komurov, Mian MK Shahzad, Justin N. Bottsford-Miller, Takayuki Enomoto, Tadashi Kimura, Prahlad T. Ram, Kathleen M. Schmeler, Michael Frumovitz, Gary G. Gallick, Kwong K. Wong, Anil K. Sood
Journal: Cancer Research (2011)

Abstract BACKGROUND: Mucinous ovarian carcinomas have a distinct clinical pattern compared to other subtypes of ovarian carcinomas. We evaluated (i) stage-specific clinical significance of mucinous ovarian carcinomas in a large cohort and (ii) the functional role of src kinase in pre-clinical models of mucinous ovarian carcinoma. METHODS: 1302 ovarian cancer patients including 122 (9.4%) cases of mucinous carcinomas were evaluated for survival analyses. Gene microarrays with src specific functional analysis were performed to identify biomarkers for 2 mucinous ovarian cancer cell lines compared with 5 serous ovarian cancer cell lines. Biological effects of src kinase inhibition were tested in a novel orthotopic mucinous ovarian cancer model (RMUG-S-ip2) using dasatinib-based therapy, an oral src kinase inhibitor. RESULTS: Patients with advanced-stage (stage III/IV) mucinous ovarian cancer had significantly worse survival compared to those with serous histology: median overall survival, 1.67 versus 3.41 years, p=0.002; and median survival time after recurrence, 0.53 versus 1.66 years, p&amp;lt;0.0001. Gene expressions of mucinous ovarian cancer cell lines were distinct from serous ovarian cancer cell lines. Pathway analyses showed that src kinase might be a key factor in regulating a number of signaling pathways. Among 10 ovarian cancer cell lines, the RMUG-S-ip2 mucinous ovarian cancer cells showed the highest src kinase activity. Moreover, oxaliplatin treatment induced phosphorylation of src kinase and Akt. These induced activities were inhibited with concurrent administration of dasatinib. Combination therapy of oxaliplatin with dasatinib further demonstrated significant synergistic effects on reducing cell viability (interaction index &amp;lt;1), increasing apoptosis (mean percentage of total apoptotic cells in RUMG-S-ip2, untreated vs dasatinib alone vs oxaliplatin alone vs oxaliplatin and dasatinib, 4.1% vs 8.5% vs 9.5% vs 26.8%, p&amp;lt;0.01), and in vivo anti-tumor effects in the RMUG-S-ip2 model (tumor reduction rate in combination therapy: versus oxaliplatin monotherapy 79.1%, and versus dasatinib monotherapy 74.7%, both p&amp;lt;0.01). CONCLUSION: Our results suggest that poor survival of women with mucinous ovarian carcinoma is associated with resistance to cytotoxic therapy. Targeting src kinase with combination of dasatinib and oxaliplatin may be an attractive approach for further clinical development in mucinous ovarian carcinoma. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 5032. doi:10.1158/1538-7445.AM2011-5032
P990 RISK OF TUMOR SEEDING DOES NOT INCREASE BY LIVER BIOPSY FOR HEPATOCELLULAR CARCINOMA PERFORMED DURING RADIOFREQUENCY ABLATION
Authors: S.Y. Park, W.Y. Tak, Y.O. Kweon, S.Y. Jang, J.G. Park, S.Y. Ahn, E.J. Kang, J. Heo, H.Y. Woo
Journal: Journal of Hepatology (2014)
Inherited GATA3 variants are associated with Ph-like childhood acute lymphoblastic leukemia and risk of relapse
Authors: Virginia Perez-Andreu, Kathryn G Roberts, Richard C Harvey, Wenjian Yang, Cheng Cheng, Deqing Pei, Heng Xu, Julie Gastier-Foster, Shuyu E, Joshua Yew-Suang Lim, I-Ming Chen, Yiping Fan, Meenakshi Devidas, Michael J Borowitz, Colton Smith, Geoffrey Neale, Esteban G Burchard, Dara G Torgerson, Federico Antillon Klussmann, Cesar Rolando Najera Villagran, Naomi J Winick, Bruce M Camitta, Elizabeth Raetz, Brent Wood, Feng Yue, William L Carroll, Eric Larsen, W Paul Bowman, Mignon L Loh, Michael Dean, Deepa Bhojwani, Ching-Hon Pui, William E Evans, Mary V Relling, Stephen P Hunger, Cheryl L Willman, Charles G Mullighan, Jun J Yang
Journal: Nature Genetics (2013)
NON-CONTRAST ENHANCED 3D MRI YIELDS HIGH ACCURACY FOR TRANSCATHETER AORTIC valve REPLACEMENT SIZING IN COMPARISON WITH MULTISLICE COMPUTED TOMOGRAPHY AND IS SUPERIOR TO CONTRAST ENHANCED MAGNETIC RESONANCE ANGIOGRAPHY
Authors: Christoph Rodewald, Jochen Spieß, Horst Brunner, Andreas Kuemmel, Thomas Walcher, Jochen Woehrle, Wolfgang Rottbauer, Peter Bernhardt
Journal: Journal of the American College of Cardiology (2013)
Experimental Inclusion Conjunctivitis in Man
Authors: Ernest Jawetz
Journal: JAMA (1965)

Trachoma is a progressive, blinding eye disease endemic in many parts of the world. In 1907 Halberstaedter and Prowazek<sup>1</sup>described the typical inclusion bodies and considered their component elementary bodies to be the etiologic agent of the disease. Soon thereafter, these same investigators<sup>2</sup>and others<sup>3,4</sup>demonstrated inclusion bodies of identical microscopic appearance in cases of a self-limited nongonorrheal conjunctivitis of the newborn. The source of infection for the newborn was promptly discovered in the adult genital tract by the finding of inclusions in the female cervix and the male urethra. Initially, both the genital tract involvement and the newborn eye disease were called "genital trachoma," but subsequent observations indicated that adult eye infections with the genital tract agent (acquired in swimming pools or by experimental inoculation) invariably ran a short, self-limited course without scars or pannus formation. Thus, the concept arose that the agent of inclusion conjunctivitis,
Uncertainty and rituals
Authors: Erik Z. Woody, Henry Szechtman
Journal: Behavioral and Brain Sciences (2006)

Boyer &amp; Lienard (B&amp;L) elegantly elaborate the links between normal motivational systems and psychopathology and address the evolutionary and cultural context of ritualized behaviors. However, their model omits a key property of the security-motivation (hazard-precaution) system, and this property suggests that ritualized behavior may generate an alternate satiety signal by substituting, in place of uncertainty, a problem that is verifiably solvable.
Surgeons Continue to Debate Place of Randomized Trials of Surgical Procedures
Authors: Bridget M. Kuehn
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hypokalemia and Amyotrophic Lateral Sclerosis
Authors: Randy Linde
Journal: JAMA (1981)

<h3>To the Editor.—</h3> Amyotrophic lateral sclerosis (ALS) is a progressive disease of unknown etiology in which there is destruction of the anterior horn cell, with the clinical expression of weakness and atrophy, fasciculations, and hyperreflexia. An electrolyte disturbance has not consistently been observed in this illness, yet we have recently noted persistent hypokalemia in one patient. The diagnosis of ALS had been established in June 1979. Since then the patient has had progressive involvement of the lower and upper extremities and trunk, preserving his ability to walk and swim by maintaining a schedule of exercise and rest. There were no other medical illnesses. Medications were diazepam, 10 mg at bedtime, and 50 to 100 g of lecithin daily, which was begun in April 1980. For the first four months this was taken as granules of animal lecithin mixed as a milkshake and for the past six months as soybean lecithin
Aminorex and the pulmonary circulation
Authors: J. M. Kay, P. Smith, D. Heath
Journal: Thorax (1971)

Aminorex (2-amino-5-phenyl-2-oxazoline) is an appetite-suppressing drug which was available in Switzerland from November 1965 to October 1968. In 1967 a sudden 20-fold increase in the incidence of primary pulmonary hypertension was observed in a Swiss medical clinic. It was noticed that a considerable number of these patients had taken aminorex to reduce weight. A similar increase in the incidence of primary pulmonary hypertension was encountered in other clinics in Switzerland, and also in Austria and Germany, where aminorex was available. An increased incidence of the disease has not been reported in countries where this drug was not available. A decline in the incidence of primary pulmonary hypertension has occurred in Switzerland since the withdrawal of aminorex. We have administered a high oral dose of aminorex to rats for up to 43 weeks and to dogs for 20 weeks. A detailed quantitative pathological examination of the heart and pulmonary vasculature in these animals has failed to reveal any evidence of hypertensive pulmonary vascular disease. Although there is statistical evidence linking aminorex with pulmonary hypertension, there is no proof that aminorex causes hypertensive pulmonary vascular disease in man. It is nevertheless important to enquire into the diet and history of drug ingestion in any patient with unexplained pulmonary hypertension.
Philadelphia-Chromosome-Positive and -Negative Chronic Myelocytic Leukemia
Authors: E. Z. EZDINLI
Journal: Annals of Internal Medicine (1970)

Chromosomal studies were performed on 61 adult patients with "typical chronic myelocytic leukemia. The Philadelphia (Ph1) chromosome was found in 43 patients, with equal sex distribution and with a median age of 48 years. The 18 Ph1-negative (Ph1-) patients had a median age of 66 years and were predominantly male. Absent leukocyte alkaline phosphatase was noted with equal frequency in both groups. The Ph1- patients had lower white blood cell and platelet counts and did not respond as well to antileukemic therapy. Basophilia and abnormally high platelet counts were fairly common among Ph1-positive (Ph1+) patients. The incidence of blastic crisis was approximately 50% in both groups but appeared earlier in the Ph1-negative patients. Median survival of Ph1+ patients was 40 months; that of the Ph1- group, only 8. Karyotypic analysis furnishes a subclassification of myelocytic leukemia with significant prognostic and therapeutic implications.
Abstract 3074: Detection and enumeration of circulating tumor cells using imaging flow cytometery
Authors: Shobana Vaidyanathan, Don Weldon, David Basiji, Philip Morrissey
Journal: Cancer Research (2014)

Abstract Circulating tumor cells (CTCs), released into the bloodstream from primary and metastatic cancers, are valuable tools for understanding tumor biology. However, since they are rare, their detection is hampered by low efficiency and a lack of standardization in current technologies. To overcome these problems, we used Imaging Flow Cytometery along with fluorescent RNA detection probes to collect imagery from large number of cells to assess the number of CTCs. In this study, we spiked peripheral blood mononucleated cells (PBMCs) with SKBR-3 human breast cancer cells and added probes for relevant RNA targets such as EPCAM and Her-2. Taking advantage of the probes’ ability to detect RNA in live cells, combined with the capacity to acquire multi-spectral images of large numbers of cells, we demonstrate image based parameters that can be used to assess the frequency of CTCs in an objective and statistically significant manner. Citation Format: Shobana Vaidyanathan, Don Weldon, David Basiji, Philip Morrissey. Detection and enumeration of circulating tumor cells using imaging flow cytometery. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3074. doi:10.1158/1538-7445.AM2014-3074
Leukocytosis is a risk factor for recurrent arterial thrombosis in young patients with polycythemia vera and essential thrombocythemia
Authors: Valerio De Stefano, Tommaso Za, Elena Rossi, Alessandro M. Vannucchi, Marco Ruggeri, Elena Elli, Caterina Micò, Alessia Tieghi, Rossella R. Cacciola, Cristina Santoro, Giancarla Gerli, Paola Guglielmelli, Lisa Pieri, Francesca Scognamiglio, Francesco Rodeghiero, Enrico M. Pogliani, Guido Finazzi, Luigi Gugliotta, Giuseppe Leone, Tiziano Barbui
Journal: American Journal of Hematology (2009)

There is evidence that leukocytosis is associated with an increased risk of first thrombosis in patients with polycythemia vera (PV) and essential thrombocythemia (ET). Whether it is a risk factor for recurrent thrombosis too is currently unknown. In the frame of a multicenter retrospective cohort study, we recruited 253 patients with PV (n = 133) or ET (n = 120), who were selected on the basis of a first arterial (70%) or venous major thrombosis (27.6%) or both (2.4%), and who were not receiving cytoreduction at the time of thrombosis. The probability of recurrent thrombosis associated with the leukocyte count recorded at the time of the first thrombosis was estimated by a receiver operating characteristic analysis and a multivariable Cox proportional hazards regression model. Thrombosis recurred in 78 patients (30.7%); multivariable analysis showed an independent risk of arterial recurrence (hazard ratio [HR] 2.16, 95% CI 1.12-4.18) in patients with a leukocyte count that was >12.4 x 10(9)/L at the time of the first thrombotic episode. The prognostic role for leukocytosis was age-related, as it was only significant in patients that were aged <60 years (HR for arterial recurrence 3.35, 95% CI 1.22-9.19).
Alopecia areata and auto-immunity
Authors: P.S. FRIEDMANN
Journal: British Journal of Dermatology (1981)

The prevalence of auto-antibodies against thyroid constituents, gastric parietal cells, smooth muscle cells, mitochondria, reticulin, nuclear constituents and rheumatoid factor in 108 patients with alopecia areata was compared with that found in a previous survey of the local population. Female patients had a significantly increased prevalence of anti-thyroid antibodies which were present in 30% overall and in 44% of the youngest age group (11–17 years). Smooth muscle antibodies were more frequent in female patients but the increase was not significant. Male patients had a significantly increased prevalence of thyroid and gastric parietal cell antibodies (11.4% each). In females, antithyroid antibodies were associated with extensive hair loss: they were found in 42% of female patients with total alopecia and only 20% of males with total hair loss. A family history of alopecia areata was obtained from 24% of patients; 10% had relatives with thyroid disease and 10% had diabetic relatives. These findings confirm the association between alopecia areata and the other auto-immune diseases.
TYPHOID FEVER.Read in the Section on Practice of Medicine, at the Forty-fifth Annual Meeting of the American Medical Association, held at San Francisco, June 5-8, 1894.
Authors: JOHN ELIOT WOODBRIDGE
Journal: JAMA (1894)

It was my intention to have made in this paper an effort to discuss from the scientist's standpoint the etiology and treatment of typhoid fever, but the positive expressions within the past few weeks of the opinions of many of the greatest thinkers of the age, that typhoid fever can not be aborted, and in fact, that the internal exhibition of drugs can have no curative effect, warns me that I have essayed enough and that this paper had better be devoted to strengthening the evidence that the claims already made are valid, and avoid as much as possible enlarging the territory which I shall have to defend. I feel that I do not owe the Section any apology for this change, because this is a disease that according to eminent authority "destroys annually the lives of 50,000 of our people, leads to the very brink of the grave more
P176Distribution of endotheltial surface layer anchoring proteins analyzed with super resolution microscopy
Authors: A Marki, M Boehme, S Sigrist, A Zakrzewicz, A Pries
Journal: Cardiovascular Research (2014)

Introduction: The endothelial surface layer (ESL, glycocalyx) is known to be anchored to membrane bound proteins (syndecan-1,-2,-4 and glypican-1), glycoproteins (e.g. CD44) and enzymes (e.g. hyaluronan synthase-1,-2,-3). Little is known about the concentration and distribution of these anchoring elements on the endothelial surface. methods: Human umbilical vein endothelial cells (HUVEC) cultured under static conditions or in the presence of shear stress (24h, non-pulsatile 8dyn/cm2) were fixed and immunostained against syndecan-1,-4 and CD44. To analyze the frequency and location of anchoring points on the endothelial cells, the samples were imaged with confocal microscopy and with gated stimulated emission depletion (STED) microscopy. Gated STED was used to resolve individual syndecan-1, and -4 anchoring sites and assess possible clustering of these individual anchoring molecules. Results: Syndecan-1 was found to be distributed on the endothelial cell surface with density of 0.13 foci/μm2 and with 2.6±0.9 μm average distances between two foci. Shear stress treatment had only slight effect on these values (after shear stress 0.07 foci/μm2 and 2.7±1 μm). Syndecan-4 was detected on the endothelial cell surface with density of 0.6 foci/μm2 and with distance between two foci of 1.3±0.4 μm. These values were unaffected by shear stress treatment (after shear stress 0.6 foci/μm2 and 1.2±0.3 μm). In some cases confocal scanning showed clusters of syndecan-1 and -4 but gated STED could resolve these sites and could show that these cluster-like structures are composed of individual foci situated close to each other. Based on that the observed foci may corresponding to non-clustered syndecan-1 or -4 molecules. CD44 was present on the endothelial cell surface with 1.3 foci/μm2 density and with 0.8±0.3 μm distance between the foci which values weren't altered by shear stress (after shear stress 1.5 foci/μm2 and 0.8±0.2 μm). Conclusion: The amount and distribution of ESL anchoring proteins on the surface of static or shear stress treated HUVECs was determined with confocal and gated STED microscopy. This information helps to better understand the spatial organization of the ESL.
Effect of propranolol and disopyramide on left ventricular function at rest and during exercise in hypertrophic cardiomyopathy
Authors: A. Hartmann, J. Kühn, R. Hopf, H. Klepzig, R. Standke, G. Kober, F.D. Maul, G. Hör, M. Kaltenbach
Journal: Journal of the American College of Cardiology (1991)
Research groups fail to reach agreement on protocol for treatment trials for CJD
Authors: Owen Dyer
Journal: BMJ (2004)

The long running squabble holding up treatment trials for Creutzfeldt-Jakob disease (CJD) in Britain surfaced again last week when the former chairman of the Prion Trial Steering Committee, Professor Iain Chalmers, said in an article in the Times Higher Education Supplement (5 March, p 1) that a “bitter relationship” between the two leading research institutions was delaying agreement on a national research framework.

The Medical Research Council's Prion Unit at the Institute of Neurology in London has been unable to agree a trial protocol with the CJD Surveillance Unit at Edinburgh University. Both units, however, are now saying they expect to deliver a protocol by Easter.

“There's no good reason …