tbuckley/cabot-search huggingface dataset:
Robert Livingstone Orchardson
Authors: Robin Orchardson
Journal: BMJ (2004)

Forde Cayley went from medical school straight into service in wartime France and then to Singapore.Captured by the Japanese, he was taken to the infamous River Kwai.The horrors he had witnessed never left him, but he believed in reconciliation, not hatred.As a postwar pioneer of drug treatment for tuberculosis, he took up the respiratory medicine post that he held until retirement.His spare time was divided between BMA activities, his work as a lay reader, and in his prolific vegetable plot.Predeceased by his wife, Eileen, he leaves two sons and three grandsons.
Points: AIDS and intravenous drug use
Authors: D J Goldberg
Journal: BMJ (1987)

suggest that they are at high risk of developing leptospirosis, the remarkably low incidence of the disease in such communes argues to the contrary.The clustering of so many cases in the commune, the finding of only a moderate rise in the tempera- ture at the centre of a meatball cooked on a hot plate,2 and the very peculiar interaction of the index case with the commune strongly suggested that food was the common source.
A Commentary on Professor John Warren's Paper, Remarks on Angina Pectoris
Authors: C. Sidney Burwell
Journal: New England Journal of Medicine (1962)

TO comment on Professor John Warren's paper on angina pectoris requires that it be seen in some relation to the history of medicine, the history of the knowledge of angina pectoris and the history of John Warren himself.As a preface, one may consider the medical education and training of the author. John Warren was born on July 27, 1753, the fourth son of a well-to-do farmer in Roxbury. He went to the Public Latin School, and in 1767 at the age of fourteen he entered Harvard College. He was awarded the degree of A.B. in 1771. While he was . . .
Watch Your Language
Authors: Hugh H. Hussey
Journal: JAMA (1977)

<h3>To the Editor.—</h3> The essay by Blacher and Levine, "The Language of the Heart" (236:1699, 1976), could well be extended to physicians' failures to communicate appropriately and gently with patients about other organic disorders. A physician's ability to give patients understanding without fear is an essential part of the art of medicine. Terms and ideas about diseases need not always be replaced by euphemisms or coated thickly with sugar, providing the physician avoids jargon (Blacher and Levine cited "cabbage" for coronary artery bypass graft) and supplements difficult words with simple analogies or diagrams. On the latter point, readers are referred to an atlas<sup>1</sup>that is an admirable guide to explanation by the kinds of drawings that any physician can use. I hope the book is still in print.
Sanity or Insanity and The Criminal Act
Authors: Eric H. Marcus
Journal: JAMA (1967)

To the Editor:—  Dr. Scrignar's article ( 201 :343, 1967) accurately highlights the existing confusion between  determinations and the issue of  at the time of commission of a crime.  Pretrial  hearings certainly should not admit into evidence data concerning  at time of the commission of the crime. However, this does not preclude the physician from evaluating and expressing an opinion in his report concerning both issues, since frequently the court has requested an opinion regarding both issues. Furthermore, if the physician's reasoning in arriving at his conclusions is spelled out, the court is better able to evaluate whether the physician had had a clear understanding of the distinction between present competency and insanity at the time of commission of the alleged crime. A single examination regarding both of the above issues precludes unnecessary duplication of examinations.
Living in the moment
Authors: L V Campbell
Journal: BMJ (2008)

“Eyes closed everyone. Just be in the moment. No extraneous thoughts at all, only your own sensations. Stay completely in the moment . . . totally relaxed. Soon you will be able to do this anywhere, any time, without even closing your eyes.”

The soothing voice flowed over the group of overstressed health professionals, who were straining to absorb the latest and the best in stress management. Doctors, nurses, and dietitians were trying hard to capture a feeling normally foreign to health workers: total submission to their immediate sensations. But the simple instructions proved difficult for people coiled as tightly as springs, always ready to face the next challenge or assault. Our enthusiastic young physiotherapist tutor looked disappointed and decided to call it a day earlier than expected. As we filed out he handed out printed summaries for us to study later.

As we emerged from the dim interior the issues of the day descended on us like a toxic cloud, filling our thoughts. Although we knew that most of the problems we wrestle with each day are forgotten in a year, swamped by even …
Remission in systemic lupus erythematosus after combination chemotherapy for Hodgkin's disease
Authors: J. S. Goodwin
Journal: JAMA (1980)

IT IS generally agreed that the prognosis for patients with systemic lupus erythematosus (SLE) improves dramatically after the introduction of high-dose corticosteroids.<sup>1,2</sup>Evidence of benefit from treatment with cytotoxic agents is less compelling, but many authorities recommend them for patients with diffuse proliferative glomerulonephritis or cerebritis.<sup>2</sup>Lack of positive proof of their efficacy is due to difficulty in obtaining the large number of patients required for a thorough study (ie, one that avoids the type II error of finding no difference between treatment groups, even though one exists). In the absence of such studies, individual judgments are based more on clinical experience and anecdotal reports. The present report describes a man with SLE who experienced a prolonged, complete, clinical and serological remission from the disease after combination chemotherapy for coincidental Hodgkin's disease. This case is presented to raise the question of whether effective combination chemotherapy might be safer
769. Genes Encoding Receptors, Signal Transducers and Transcription Regulators Are Preferred Targets of Retroviral Vector Integration in T-Lymphocytes In Vitro and In Vivo
Authors: Frank A. Giordano, Boris Fehse, Agnes Hotz-Wagenblatt, Sunitha Jonnakuty, Coral Del Val, Jens-Uwe Appelt, Katalin Z. Nagy, Klaus Kuehlcke, Sonja Naundorf, Axel R. Zander, W. Jens Zeller, Stefan Fruehauf, Stephanie Laufs
Journal: Molecular Therapy (2006)

Graft-versus-host-disease (GvHD) is a severe complication in the context of allogeneic stem cell transplantation and adoptive immunotherapy. The transfer of a suicide gene into donor T-lymphocytes (TLCs) allows to selectively eliminate GvHD-causing cells. Since retroviral gene transfer into hematopoietic stem cells can induce leukemia there is an urgent need to analyze retroviral integration sites also in TLCs. We examined suicide gene transduced TLCs in four grafts and from four transplanted patients. Additionally, we generated a random integration pattern which was used for comparison of integration site data.
Drug Use and Sexual Activity on a College Campus
Authors: ERICH GOODE
Journal: American Journal of Psychiatry (1972)

A questionnaire study on one college campus revealed that drug users were significantly more likely to engage in sexual intercourse, to engage in it earlier in life, and to engage in it regularly and with a greater variety of partners. This held true regardless of the specific indicator of drug use employed, as well as when the two control variables, gender and class in college, were introduced.
Not So Great Moments
Authors: Howard Markel
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Epstein-Barr virus and persistent graft dysfunction after liver transplantation
Authors: Amadlo Telenti, Thomas F. Smith, Jurgen Ludwig, Michael R. Keating, Rund A. F. Krom, Russell H. Wiesner
Journal: Hepatology (1991)

Epstein-Barr virus infection has been associated with a broad spectrum of clinical manifestations, depending on the immune status of the host. In this report, we describe two liver transplant patients who received hepatic allografts from donors serologically positive for Epstein-Barr virus and who experienced primary infection with Epstein-Barr virus associated with prolonged liver graft dysfunction. In both patients, Epstein-Barr serologies converted within 3 mo of liver transplantation, and hepatic histological study revealed mononuclear infiltration of the sinusoids evolving to pronounced immunoblastic features suggestive of evolving lymphoma. In both cases, in situ hybridization studies confirmed the presence of Epstein-Barr virus genome in the liver. Furthermore, polymerase chain reaction analysis suggested that high levels of Epstein-Barr virus DNA were present in biopsy specimens obtained during the episode of acute hepatitis that followed Epstein-Barr virus seroconversion. The degree of Epstein-Barr virus DNA estimated by polymerase chain reaction appeared to increase in parallel with the progression of parenchymal lymphocytic infiltrates. In one patient, a biopsy sample from a cervical node also revealed high levels of Epstein-Barr virus DNA estimated using the polymerase chain reaction technique. Furthermore, in these patients, Epstein-Barr virus DNA levels appeared to decrease dramatically after discontinuing azathioprine administration and beginning treatment with acyclovir. These two cases illustrate the dynamics of Epstein-Barr virus immune regulation and confirm chronic hepatic allograft dysfunction related to Epstein-Barr viral infection.
The epidemiology of disasters and adverse reproductive outcomes: lessons learned.
Authors: J F Cordero
Journal: Environmental Health Perspectives (1993)

A disaster has been defined as a disruption of human ecology that exceeds the capacity of the community to function normally. Little is known about the adverse effects of natural disasters on reproductive outcomes. Important lessons can be derived from several disasters caused by human factors, such as the Minamata Bay disaster. Adverse reproductive outcomes include infertility, early pregnancy loss, stillbirths, congenital malformations, and serious developmental disabilities such as cerebral palsy and mental retardation. Recent disasters like the Chernobyl and Bhopal explosions have provided important lessons on the need for accurate and sound information about the risk of prenatal exposures for adverse reproductive outcomes. To study questions of adverse reproductive outcomes and disasters requires a well-planned approach. It should include early development of surveillance for adverse reproductive outcomes, analytic studies on the risk of disasters from direct and indirect effects, sensitive methods to measure early pregnancy loss, and long-term follow-up programs to assess outcomes such as developmental disabilities.
The Nervous System and Behavior
Authors: Sidney Schulman
Journal: JAMA (1982)

This book is one of the latest of the numerous paperback texts of neurophysiology to be published in recent years, and in some important respects, it is the best of them for its intended audience. The book was developed in part from lectures for medical students given by the author at the University of Nebraska College of Medicine. I would guess with some confidence that he is an excellent teacher. At the very least, it is obvious that he has genuine and serious respect for what it means to be a scholar and teacher.  Like other texts of its kind, this one does not have the formal tone or the pretensions to encyclopedic range of the full-dress, multiauthored textbook of physiology. But the author is clearly at home with his subject, which, though it is presented in a personal and conversational way, receives a no-nonsense treatment, without sacrifice of detail
Measuring brain natriuretic peptide in suspected left ventricular systolic dysfunction in general practice: cross-sectional study
Authors: M. J Landray
Journal: BMJ (2000)

The prevalence of heart failure is increasing. 1 Patients usually present to their general practitioner but a definitive diagnosis of left ventricular systolic dysfunction can only be achieved by cardiac imaging.Measuring plasma concentrations of brain natriuretic peptide has been advocated as a screening test that might reduce demands on cardiological services. 2 We report the results of a community based study designed to investigate the effectiveness of measuring brain natriuretic peptide to diagnose left ventricular systolic dysfunction.The study was approved by the local research ethics committee.
The Calcium Deficiency Hypothesis of Hypertension
Authors: David A. McCARRON, Cynthia D. Morris
Journal: Annals of Internal Medicine (1987)

The proposed role of maintenance of calcium homeostasis in the prevention and nonpharmacologic treatment of hypertension has prompted controversial interpretations of the data on which the proposal is based. To provide a more current perspective, we summarize the epidemiologic data, results of clinical studies of calcium metabolism in humans with hypertension, effects of controlled interventions of calcium supplementation in humans, and findings from laboratory studies intended to elucidate possible mechanisms. Data from the epidemiologic and clinical trials support a protective role for calcium in regulating arterial pressure. A potentially important relationship between the "calcium hypothesis" and "salt-sensitivity" may provide further insights into the mechanisms involved. Results of experiments in vascular physiology indicate that dietary calcium's effect in lowering blood pressure is mediated in part through direct action on the vasculature.
Nasal Obstruction as a Cause of Sudden Death
Authors: Knut Naess
Journal: JAMA (1968)

<h3>To the Editor:—</h3> I should like to mention the possibility of a connection between nasal obstruction as a cause of sudden death (as described in your editorial [<b>205</b>:639, 1968]) and the use of acetylsalicylic acid (aspirin). An annotation has recently described a number of more or less serious complications due to an idiosyncratic (not allergic) response to aspirin (<i>Lancet</i><b>2</b>:618, 1968). Aspirin is also said to be a powerful histamine releaser in predisposed patients. In your editorial it is mentioned that "the majority who die have a history of preceding minor respiratory illness." This condition will often call for aspirin (not seldom used in too high doses for young infants), and thus the etiology suggested here should not be improbable.
Response to Letter Regarding Article, “Renal Insufficiency Following Contrast Media Administration Trial (REMEDIAL): A Randomized Comparison of 3 Preventive Strategies”
Authors: Carlo Briguori, Davide D’Andrea, Amelia Focaccio, Bruno Ricciardelli, Flavio Airoldi, Nuccia Morici, Iassen Michev, Matteo Montorfano, Mauro Carlino, John Cosgrave, Antonio Colombo, Erminio Bonizzoni
Journal: Circulation (2007)
The Chorus scheme: Representation or isomorphism, holistic or analytic?
Authors: Cyril Latimer
Journal: Behavioral and Brain Sciences (1998)

The Chorus scheme could be an important step in the search for solutions to the symbol grounding problem (Harnad 1990), but Edelman does not address the potential difficulties inherent in downgrading differences in favor of similarities in a categorization device. Isomorphism rather than representation is a more coherent way of thinking about Chorus whose modules are probably analytic rather than holistic.
Program death-1 signaling and regulatory T cells collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes in advanced acute myeloid leukemia
Authors: Qing Zhou, Meghan E. Munger, Steven L. Highfill, Jakub Tolar, Brenda J. Weigel, Megan Riddle, Arlene H. Sharpe, Daniel A. Vallera, Miyuki Azuma, Bruce L. Levine, Carl H. June, William J. Murphy, David H. Munn, Bruce R. Blazar
Journal: Blood (2010)
Abstract 625: Preclinical characterization of an auristatin-based anti-CD19 drug conjugate, SGN-19A
Authors: Che-Leung Law, May Sutherland, Jamie Miyamoto, Dawn Hayes, Steve Duniho, Tamar Boursalian, Ivan Stone, Mechthild Jonas, Leia Smith, Dennis Benjamin
Journal: Cancer Research (2011)

Abstract CD19 has multiple attributes that make it an attractive target for an antibody-drug conjugate (ADC). CD19 is uniformly expressed on the cell surface of almost all malignancies of B cell origin, including non-Hodgkin lymphoma (NHL), B cell precursor acute lymphoblastic leukemia (B-ALL), and chronic lymphocytic leukemia (CLL). In addition, CD19 has very limited normal tissue expression, restricted only to B lymphocytes and their precursors, and it internalizes rapidly, which are favorable characteristic for targeted drug delivery. SGN-19A is an ADC comprised of a humanized anti-CD19 mAb and the potent cytotoxic drug-linker maleimidocaproyl monomethyl auristatin F (mcMMAF). Here we demonstrate internalization and trafficking, in vivo antitumor activity, and in vivo on-target pharmacodynamic effect of B cell depletion following SGN-19A treatment. Internalization and trafficking of SGN-19A through the endosomal-lysosomal pathway resulted in potent in vitro cytotoxic activity against CD19+ cell lines derived from B-ALL, follicular lymphoma, diffused large B cell lymphoma, Burkitt's lymphoma, and plasma cell leukemia. In mouse xenografts modeling different B-lineage malignancies, SGN-19A demonstrated antitumor activity including tumor regression and prolonged survival at doses well below its maximum tolerated dose. We also show that the in vivo antitumor activity is directly related to the duration of the pharmacokinetic half-life among a panel of ADCs targeting CD19. Since SGN-19A cross-reacts with its ortholog expressed in non-human primates, we examined its pharmacodynamic effect on B cell depletion in cynomolgus monkeys. Depletion of peripheral B cells was observed following SGN-19A and correlated with results from terminal immunohistochemical (IHC) analysis demonstrating the depletion of Ki67+ germinal center B cells. Furthermore, using an antibody against mcMMAF we confirmed delivery of the cytotoxic agent to the B cell areas in peripheral lymphoid tissues. Taken together, these results support the further evaluation of SGN-19A as a therapy for B-lineage derived malignancies. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 625. doi:10.1158/1538-7445.AM2011-625
Reinitiation of sperm production in gonadotropin-suppressed normal men by administration of follicle-stimulating hormone
Authors: Alvin M. Matsumoto, Anthony E. Karpas, C. Alvin Paulsen, William J. Bremner
Journal: Journal of Clinical Investigation (1983)

The specific roles of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in controlling human spermatogenesis are poorly understood. We studied the effect of an experimentally induced, selective LH deficiency on sperm production in normal men. After a 3-mo control period, five men received 200 mg testosterone enanthate (T) i.m./wk to suppress LH, FSH, and sperm counts. Then, while continuing T at the same dosage, human FSH (hFSH) was administered simultaneously to replace FSH activity, leaving LH activity suppressed. Four men received 100 IU hFSH s.c. daily plus T (high dosage hFSH) for 13-14 wk, while one man received 50 IU hFSH s.c. daily plus T (low dosage hFSH) for 5 mo. The effect on sperm production of the selective LH deficiency produced by hFSH plus T administration was assessed.
Textbook of Pediatric Infectious Diseases
Authors: Richard M. Rutstein
Journal: JAMA (1994)

As a pediatrician in practice initially at an urban health center and now at a university-based program, I have found that the most common diagnostic and treatment issues requiring my retreat to the reference shelf involve infectious diseases and their manifestations in children. With my practice now largely devoted to caring for children infected with the human immunodeficiency virus (HIV), this is even more the case. Although there are several outstanding general pediatric textbooks available that cover most infectious disease topics, I found the breadth and depth of information in them insufficient. In contrast, in the 12 years since the first edition of this text appeared, I have found it to be the best single reference on pediatric infectious diseases. This eagerly awaited third edition has met my expectations and continues to be the reference book I use most over the course of the year. With more than 180 contributors
The Centers for Medicare and Medicaid Services
Authors: John K. Iglehart
Journal: New England Journal of Medicine (2001)

Progress on the nation's health policy agenda, like so many other things, was interrupted by the tragic events of September 11. However, that disaster has not changed a view shared by Democratic and Republican policymakers: the Centers for Medicare and Medicaid Services (CMS), formerly known as the Health Care Financing Administration (HCFA), is badly in need of repair. The federal agency is the single largest purchaser of health care in the world, with an estimated $476 billion paid for health care services in 2001 on behalf of 70 million disabled, elderly, and poor beneficiaries. In recent years, however, the agency . . .