tbuckley/cabot-search huggingface dataset:
Involvement of 5-lipoxygenase/cysteinyl leukotriene receptor 1 in rotenone- and MPP+-induced BV2 microglial activation
Authors: Yanfang Wang, Xiaoyan Zhang, Chengtan Li, Jianbo Zhao, Erqing Wei, Lihui Zhang
Journal: Molecular Neurodegeneration (2012)

Background Neuroinflammation plays a prominent role in the pathogenesis of Parkinson’s disease (PD), and microglial activation contributes to initiating and maintaining brain inflammation and neuronal death. 5-Lipoxygenase (5LOX) is a key enzyme catalyzing arachidonic acid to produce cysteinyl leukotrienes (CysLTs). CysLTs are potent proinflammatory mediators, and their actions are mediated by activating CysLT receptors. We recently reported that rotenone time- and concentration-dependently induced 5-LOX translocation into the nuclear envelope (a key event for 5-LOX activation) and cell injury in PC12 cells, and the 5-LOX selective inhibitor zileuton attenuated rotenone-induced 5-LOX activation and cell injury. To determine the role of 5-LOX pathway in microglial-dependent neuroinflammation, we investigated the changes of 5-LOX and CysLT1 receptor in a cell model of PD induced by specific mitochondrial complex I inhibitors (rotenone or 1-methyl-4-phenylpyridinium (MPP + )) in BV2 microglial cells. Methods BV2 cells, a murine BV2 microglia cell line, were cultured in media with or without rotenone (0.1, 0.3, 1, 3, 10 nM) or MPP + (0.003, 0.01, 0.03, 0.1, 0.3 μM) for 24
GMC must protect patients says government minister
Authors: Clare Dyer
Journal: BMJ (2005)

BMJ 

Harold Shipman probably began to kill patients within a year of leaving medical school, taking his full toll of murders to 250 patients, the inquiry into Shipman's 30 year career concluded last week.

Dame Janet Smith, the appeal court judge who carried out the three year inquiry, reached the conclusion in her sixth and final report, which looked at his earliest years in practice as a junior hospital doctor.

On the day she released her findings, the health secretary, John Reid, announced a major review of the way doctors are assessed for their fitness to practise, and the role of their regulatory body, the General Medical Council.

The review, to be conducted by the chief medical officer, Professor Liam Donaldson, aims to strengthen the procedures …
Differential effects of growth hormone therapy in malnourished hemodialysis patients
Authors: Harald Kotzmann, Nilgün Yilmaz, Piero Lercher, Michaela Riedl, Alice Schmidt, Ernst Schuster, Sören Kreuzer, Georg Geyer, Herwig Frisch, Walter H. Hörl, Gert Mayer, Anton Luger
Journal: Kidney International (2001)
Study of Involuntary Weight Loss
Authors: MARSHALL B. BLOCK
Journal: Annals of Internal Medicine (1982)

Letters and Corrections1 April 1982Study of Involuntary Weight LossMARSHALL B. BLOCK, M.D.MARSHALL B. BLOCK, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-96-4-528_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I have just read the article on involuntary weight loss (1), and I am not certain I understand why it was published. Those of us in practice are well aware of the authors' conclusion that patients with weight loss without an apparent cause need to be evaluated because most do have serious problems, both medical as well as psychiatric (if they can actually be distinguished). Because these authors concluded that "many clinicians may still wish to do screening laboratory tests in all patients with weight loss rather than only in those with a screening score of 8...Reference1. MARTONSOXKRUPP KHJ. Involuntary weight loss: diagnostic and prognostic significance. Ann Intern Med. 1982;96:568-74. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Arizona Medicine, Phoenix, AZ 85013 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1982Volume 96, Issue 4Page: 528-528KeywordsLaboratory testsPatientsWeight loss Issue Published: 1 April 1982 PDF downloadLoading ...
PSA Testing
Authors: Peter C. Albertsen
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Electrophysiological features of the mouse sinoatrial node in relation to connexin distribution
Authors: E Verheijck
Journal: Cardiovascular Research (2001)

The sinoatrial (SA) node consists of a relatively small number of poorly coupled cells. It is not well understood how these pacemaker cells drive the surrounding atrium and at the same time are protected from its hyperpolarizing influence. To explore this issue on a small tissue scale we studied the activation pattern of the mouse SA node region and correlated this pattern with the distribution of different gap junction proteins, connexin (Cx)37, Cx40, Cx43 and Cx45.The mouse SA node was electrophysiologically mapped using a conventional microelectrode technique. The primary pacemaker area was located in the corner between the lateral and medial limb of the crista terminalis. Unifocal pacemaking occurred in a group of pacemaking fibers consisting of 450 cells. In the nodal area transitions of nodal and atrial waveform were observed over small distances ( approximately 100 microm). Correlation between the activation pattern and connexin distribution revealed extensive labeling by anti-Cx45 in the primary and secondary pacemaker area. Within these nodal areas no gradient in Cx45 labeling was found. A sharp transition was found between Cx40- and Cx43-expressing myocytes of the crista terminalis and the Cx45-expressing myocytes of the node. In addition, strands of myocytes labeled for Cx43 and Cx40 protrude into the nodal area. Cx37 labeling was only present between endothelial cells. Furthermore, a band of connective tissue largely separates the nodal from the atrial tissue.Our results demonstrate strands of Cx43 and Cx40 positive atrial cells protruding into the Cx45 positive nodal area and a band of connective tissue largely separating the nodal and atrial tissue. This organization of the mouse SA node provides a structural substrate that both shields the nodal area from the hyperpolarizing influence of the atrium and allows fast action potential conduction from the nodal area into the surrounding atrium.
Ethical Issues in Biomedical Publication
Authors: Ana Marusic
Journal: Annals of Internal Medicine (2001)

Medical Writings: Book Notes21 August 2001Ethical Issues in Biomedical PublicationAna Marusic, MD, PhDAna Marusic, MD, PhDZagreb University School of Medicine, Zagreb, Croatia. (Marusic)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-135-4-200108210-00033 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Hudson Jones A, McLellan F, eds. 374 pages. Baltimore: John Hopkins Univ Pr; 2000. $50.00. ISBN 0801863155. Order phone 800-537-5487.Field of medicine: Biomedical publishing.Format: Softcover book.Audience: Researchers, students, and residents; journal editors; and educators and administrators.Purpose: To identify important ethical matters in biomedical publication and explore their origin and development in the larger context of ethical conduct of research, to explain evolution of current publication standards, and to present current debates about those issues.Content: Fourteen chapters are organized in three parts. Part 1 presents major ethical issues of biomedical publishing: authorship, peer review, repetitive and ... Author, Article, and Disclosure InformationAffiliations: Zagreb University School of Medicine, Zagreb, Croatia. (Marusic) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 21 August 2001Volume 135, Issue 4Page: 308KeywordsConflicts of interestPeer reviewResearch ethicsScientific misconductSoftware tools ePublished: 21 August 2001 Issue Published: 21 August 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
The interaction between osteoclast-like cells and osteoblasts mediated by nanophase calcium phosphate-hybridized tendons
Authors: Hirotaka Mutsuzaki, Masataka Sakane, Atsuo Ito, Hiromi Nakajima, Shinya Hattori, Yutaka Miyanaga, Junzo Tanaka, Naoyuki Ochiai
Journal: Biomaterials (2004)
Diagnosing familial hypercholesterolaemia in childhood by measuring serum cholesterol.
Authors: J V Leonard, A G Whitelaw, O H Wolff, J K Lloyd, J Slack
Journal: BMJ (1977)

The serum cholesterol concentrations of 134 children aged 1-16 years who had at least one first-degree relative with presumed familial hypercholesterolaemia showed a bimodal distribution, and, using the maximum likelihood technique, two overlapping curves could be fitted. The mean value of the affected children (heterozygotes) was 8-9 mmol/l and that of the unaffected 4-9 mmol/l. The two curves intersected at 6-77 mmol/l, and at this point 5% of the unaffected children had values over 6-77 mmol/l and 3-5% of the heterozygotes had values under 6-77 mmol/l. If this cholesterol concentration is used as a cut-off point 4-25% of cases would be misdiagnosed.
Grand Cru versus Generic: Different Approaches to Altering the Ratio of General Internists to Subspecialists
Authors: Jay H. Stein
Journal: Annals of Internal Medicine (1991)

In the last decade internal medicine has become a less popular career choice among medical school graduates. In addition, there has been an increase in the percentage of internal medicine residents choosing subspecialty training. The factors that have led to the change in the ratio of subspecialists to general internists are discussed, and a plan is proposed that would make the practice of general internal medicine more attractive and reduce the number of subspecialty training positions in the United States.
Oral hairy leukoplakia in a HIV-negative renal graft recipient
Authors: J. KANITAKIS, SYLVIE EUVRARD, NICOLE LEFRANCOIS, C. HERMIER, J. THIVOLET
Journal: British Journal of Dermatology (1991)

Journal Article Oral hairy leukoplakia in a HIV‐negative renal graft recipient Get access J. KANITAKIS, J. KANITAKIS Dermatopathology Laboratory, Department of Dermatology, Ed. Herriot Hospital, Lyon, France Dr J.Kanitakis, Department of Dermatology, Ed. Herriot Hospital. 69437 Lyon Cedex 03. France. Search for other works by this author on: Oxford Academic Google Scholar SYLVIE EUVRARD, SYLVIE EUVRARD Dermatopathology Laboratory, Department of Dermatology, Ed. Herriot Hospital, Lyon, France Search for other works by this author on: Oxford Academic Google Scholar NICOLE LEFRANCOIS, NICOLE LEFRANCOIS Department of Nephrology and Transplantation, Ed. Herriot Hospital, Lyon, France Search for other works by this author on: Oxford Academic Google Scholar C. HERMIER, C. HERMIER Dermatopathology Laboratory, Department of Dermatology, Ed. Herriot Hospital, Lyon, France Search for other works by this author on: Oxford Academic Google Scholar J. THIVOLET J. THIVOLET Dermatopathology Laboratory, Department of Dermatology, Ed. Herriot Hospital, Lyon, France Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 124, Issue 5, 1 May 1991, Pages 483–486, https://doi.org/10.1111/j.1365-2133.1991.tb00631.x Published: 01 May 1991
THE MAIN CAUSES OF INJURIES SUSTAINED AT FITNESS FACILITIES PRESENTING TO VICTORIAN EMERGENCY DEPARTMENTS: IDENTIFYING THE CULPRITS
Authors: S Gray, CF Finch
Journal: British Journal of Sports Medicine (2014)

Background Fitness facilities provide an important avenue for people to increase their physical activity; however they can also be a common context of injury. The only source of routinely collected data about injuries associated with fitness activities is the Victorian Emergency Minimum Dataset as used by the Victorian Injury Surveillance Unit. This includes injury presentations to all public Victorian emergency rooms with a 24-hour service. Each case is accompanied by a 250-character narrative that provides further details surrounding the circumstances of the injury. Objective To determine the main causes of injury associated with fitness activities. Design Analysis of emergency department case narratives from 2002/03 to 2011/12. Participants 1 979 de-identified injured persons who presented to included Victorian emergency departments. Main outcome measurements Textual analysis and summary of the narratives to identify specific causes of injuries sustained in fitness facilities to lead potential injury prevention efforts. Results The leading cause of injury depended on the type of activity being participated in (i.e. resistance training, aerobics/group exercise and use of other equipment). Across all fitness activities, the leading specified cause of injury was hit/struck/crush (50.9%) however this was largely driven by the high proportion of resistance training hit/struck/crush injuries (82.6% of all resistance training injuries). Falls were the leading specified cause of injury for aerobics and other equipment (62.4% and 63.2%, respectively). Most cases were not severe, with only 7.5% subsequently admitted to hospital. Conclusion: Injury prevention efforts should be specific to particular activities commonly participated in at fitness facilities, as the specific causes of injuries vary across these.
Rationing Salt Water — Disaster Planning and Daily Care Delivery
Authors: John L. Hick, Dan Hanfling, Brooke Courtney, Nicole Lurie
Journal: New England Journal of Medicine (2014)

The national shortage of normal saline represents a new chapter in supply shortages. But emergency-management methods offer a systematic approach to day-to-day shortages and prepare institutions to use those methods more effectively during large-scale disasters.
234 ROLE OF YAP IN THE REGULATION OF XENOBIOTIC-INDUCED LIVER ENLARGEMENT AND HCC DEVELOPMENT
Authors: M.A. Kowalik, C. Saliba, M. Pibiri, G.M. Ledda-Columbano, I. Sarotto, E. Ghiso, S. Giordano, A. Columbano
Journal: Journal of Hepatology (2011)
Looking Beyond the Retina
Authors: Peter M. Scialli
Journal: JAMA (1988)

To the Editor.  —Diabetes is responsible for more than 12% of all new cases of blindness 1 and 20% of all new blindness in individuals between the ages of 45 and 74 years. 2 Laser therapy is capable of decreasing visual loss by 50% or more in patients treated adequately and in time. 3 Despite the tremendous potential for laser therapy to reduce diabetic visual loss, there are three preliminary steps to adequate and timely therapy: (1) annual ophthalmologic evaluations after puberty or after five years of diabetes, whichever comes last 4 ; (2) adequate evaluation and appropriate treatment recommendations; and (3) follow through with the recommended treatment. Although there are no available data on the impact of laser therapy since its implementation in routine clinical practice, we have seen three patients with a breakdown in this process that interfered with the prevention of visual impairment.  We have recently begun a
Expanding Autonomy; Contracting Informed Consent
Authors: Joseph P. DeMarco, Douglas O. Stewart
Journal: The American Journal of Bioethics (2009)

Mrs. Mary Townley, an 85-year-old widow, lived alone for more than 20 years. She is morbidly obese, has diabetes, heart failure, and severe arthritic pain in her left knee. As a result of her disab...
Integrated approach for the identification of human hepatocyte nuclear factor 4α target genes using protein binding microarrays
Authors: Eugene Bolotin, Hailing Liao, Tuong Chi Ta, Chuhu Yang, Wendy Hwang-Verslues, Jane R. Evans, Tao Jiang, Frances M. Sladek
Journal: Hepatology (2009)

Hepatocyte nuclear factor 4 alpha (HNF4α), a member of the nuclear receptor superfamily, is essential for liver function and is linked to several diseases including diabetes, hemophilia, atherosclerosis, and hepatitis. Although many DNA response elements and target genes have been identified for HNF4α, the complete repertoire of binding sites and target genes in the human genome is unknown. Here, we adapt protein binding microarrays (PBMs) to examine the DNA-binding characteristics of two HNF4α species (rat and human) and isoforms (HNF4α2 and HNF4α8) in a high-throughput fashion. We identified ˜1400 new binding sequences and used this dataset to successfully train a Support Vector Machine (SVM) model that predicts an additional ˜10,000 unique HNF4α-binding sequences; we also identify new rules for HNF4α DNA binding. We performed expression profiling of an HNF4α RNA interference knockdown in HepG2 cells and compared the results to a search of the promoters of all human genes with the PBM and SVM models, as well as published genome-wide location analysis. Using this integrated approach, we identified ˜240 new direct HNF4α human target genes, including new functional categories of genes not typically associated with HNF4α, such as cell cycle, immune function, apoptosis, stress response, and other cancer-related genes. Conclusion: We report the first use of PBMs with a full-length liver-enriched transcription factor and greatly expand the repertoire of HNF4α-binding sequences and target genes, thereby identifying new functions for HNF4α. We also establish a web-based tool, HNF4 Motif Finder, that can be used to identify potential HNF4α-binding sites in any sequence. (Hepatology 2009.)
Pretreatment of cytokinetics in acute myelogenous leukemia. Age-related prognostic implications.
Authors: H M Kantarjian, B Barlogie, M J Keating, R R Hall, T L Smith, K B McCredie, E J Freireich
Journal: Journal of Clinical Investigation (1985)

To determine the clinical and biologic relevance of cellular kinetics in leukemia, DNA flow cytometric analysis was performed on bone marrow biopsy specimens from 148 previously untreated adult patients with acute myelogenous leukemia. The proportion of cells in synthesis, second growth, and mitosis (S + G2M) ranged from 4% to 33% with a median of 14%. The overall incidence of complete remission was not affected by the pretreatment cell cycle distribution. As in earlier studies, there was a marked decline in remission rate with advancing age from 73% for patients age less than or equal to 50 yr to 50% for those greater than 50 (P less than 0.01). Although not affecting remission induction overall, an increasing proportion of cells in S + G2M phase was favorable in patients under the age of 50 yr, but was associated with a progressive decline in remission rate in older patients (P = 0.01). This age-related divergent effect of cell cycle kinetics on initial response to therapy was confined to the less favorable subgroup of patients with karyotypic abnormalities, whereas patients with normal diploid cytogenetics had a consistently higher response rate regardless of proliferative activity. A positive correlation was also observed between percent of S + G2M cells and the proportion of diploid metaphases in young patients, contrasting with a negative correlation in the older age group. Our observations strongly suggest that the well-recognized prognostic effect of age on remission induction is not entirely host-mediated, but is at least partly an expression of disease-intrinsic differences between young and older patients.
Single-agent thalidomide for treatment of first relapse following high-dose chemotherapy in patients with multiple myeloma
Authors: R Fenk, B Hoyer, U Steidl, M Kondakci, T Graef, R Heuk, L Ruf, C Strupp, F Neumann, U-P Rohr, B Hildebrandt, R Haas, G Kobbe
Journal: Leukemia (2004)
Letter: Potentiation of warfarin by co-trimoxazole.
Authors: J De Swiet
Journal: BMJ (1975)

protracted and symptoms are relieved within half an hour of receiving glucose.2On the other hand, in a study of normal children (5 to 15 years of age) as little as 2 5 mg of glibenclamide produced a marked decrease in blood sugar with lower than normal blood sugar values persisting for more than six hours (six hours being the total investigation time).3In our patient there appeared to be a prolonged hypoglycaemic effect lasting 48-72 hours.Moreover, we can only conclude that the hypoglycaemia has caused per- manent cerebral damage with epilepsy.Mental retardation cannot be excluded.-Weare, etc.,
Looking after elderly sick people is core work in general practice
Authors: D. B Goss
Journal: BMJ (1997)

Editor–A recent news article seems to condone the fact that “general practitioners in several areas of Britain have successfully negotiated extra payments for the medical care of residents in nursing homes that they do not consider part of their core work.” As a retired general practitioner and hospital practitioner in geriatric medicine and now (for the past eight years or so) a designated old age pensioner, I write …
Clinical Investigation of Shock
Authors: A. C. Kanaar
Journal: BMJ (1941)

Systemic lupus erythematosus (SLE), a complex and heterogeneous autoimmune disease, represents a significant challenge for both diagnosis and treatment. Patients with SLE in Latin America face special problems that should be considered when therapeutic guidelines are developed. The objective of the study is to develop clinical practice guidelines for Latin American patients with lupus. Two independent teams (rheumatologists with experience in lupus management and methodologists) had an initial meeting in Panama City, Panama, in April 2016. They selected a list of questions for the clinical problems most commonly seen in Latin American patients with SLE. These were addressed with the best available evidence and summarised in a standardised format following the Grading of Recommendations Assessment, Development and Evaluation approach. All preliminary findings were discussed in a second face-to-face meeting in Washington, DC, in November 2016. As a result, nine organ/system sections are presented with the main findings; an ‘overarching’ treatment approach was added. Special emphasis was made on regional implementation issues. Best pharmacologic options were examined for musculoskeletal, mucocutaneous, kidney, cardiac, pulmonary, neuropsychiatric, haematological manifestations and the antiphospholipid syndrome. The roles of main therapeutic options (ie, glucocorticoids, antimalarials, immunosuppressant agents, therapeutic plasma exchange, belimumab, rituximab, abatacept, low-dose aspirin and anticoagulants) were summarised in each section. In all cases, benefits and harms, certainty of the evidence, values and preferences, feasibility, acceptability and equity issues were considered to produce a recommendation with special focus on ethnic and socioeconomic aspects. Guidelines for Latin American patients with lupus have been developed and could be used in similar settings.