tbuckley/cabot-search huggingface dataset:
Regenerative effects of transplanting mesenchymal stem cells embedded in atelocollagen to the degenerated intervertebral disc
Authors: Daisuke Sakai, Joji Mochida, Toru Iwashina, Akihiko Hiyama, Hiroko Omi, Masaaki Imai, Tomoko Nakai, Kiyoshi Ando, Tomomitsu Hotta
Journal: Biomaterials (2005)
Studies of the Immunologic Defects Associated with Intestinal Lymphangiectasia
Authors: JAMES E. MCGUIGAN
Journal: Annals of Internal Medicine (1968)

Studies in a patient with lymphangiectasia, lymphedema, lymphocytopenia, and hypogammaglobulinemia suggest that immunologic defects observed in such patients are correlated with excessive globulin catabolism rather than with an intrinsic defect in immune competence. In spite of reduced levels of serum gamma G, gamma A, and gamma M immunoglobulins fluorescein-labeling techniques showed that immunoglobulin-bearing cells of the lamina propria of the affected intestine were present in approximately normal numbers and distribution. The patient was shown to be capable of producing serum reagin antibodies. Normal numbers of lymphocytes in blood and ascitic fluid underwent transformation in response to stimulation by phytohemagglutinin and specific antigen. A unique feature of this patient with lymphangiectasia was the presence of cutaneous lymphangiomas. Long-term success in control of associated chylous ascites has been achieved by the use of a low-fat diet.
Mutational Inactivation of PTPRD in Glioblastoma Multiforme and Malignant Melanoma
Authors: David A. Solomon, Jung-Sik Kim, Julia C. Cronin, Zita Sibenaller, Timothy Ryken, Steven A. Rosenberg, Habtom Ressom, Walter Jean, Darell Bigner, Hai Yan, Yardena Samuels, Todd Waldman
Journal: Cancer Research (2008)

Abstract An additional tumor suppressor gene on chromosome 9p telomeric to the CDKN2A/B locus has long been postulated to exist. Using Affymetrix 250K single nucleotide polymorphism arrays to screen for copy number changes in glioblastoma multiforme (GBM), we detected a high frequency of deletions of the PTPRD gene, which encodes a receptor protein tyrosine phosphatase at chromosome 9p23-24.1. Missense and nonsense mutations of PTPRD were identified in a subset of the samples lacking deletions, including an inherited mutation with somatic loss of the wild-type allele. We then sequenced the gene in melanoma and identified 10 somatic mutations in 7 of 57 tumors (12%). Reconstitution of PTPRD expression in GBM and melanoma cells harboring deletions or mutations led to growth suppression and apoptosis that was alleviated by both the somatic and constitutional mutations. These data implicate PTPRD in the pathogenesis of tumors of neuroectodermal origin and, when taken together with other recent reports of PTPRD mutations in adenocarcinoma of the colon and lung, suggest that PTPRD may be one of a select group of tumor suppressor genes that are inactivated in a wide range of common human tumor types. [Cancer Res 2008;68(24):10300–6]
Hereditary Hematuria, Nephropathy and Deafness
Authors: George S. Sturtz, Edmund C. Burke
Journal: New England Journal of Medicine (1956)

THIS report is concerned with a familial renal disease associated with nerve deafness. Familial renal disease without associated nerve deafness, which has been adequately reviewed by Eason,1 Rinkoff2 and Reyersbach3 and their associates, is not discussed further here.We are of the opinion that the three following criteria are necessary for the diagnosis of this syndrome: a family history of progressive renal disease in males affected; the presence or history of hematuria, which may be intermittent; and nerve deafness in most of the males and in some of the females affected. We have thus termed this entity "hereditary hematuria, nephropathy . . .
Preinfarctional (Unstable) Angina—A Prospective Study— Ten Year Follow-Up
Authors: PETER C. GAZES, E. MIMS MOBLEY, HENRY M. FARIS, ROBERT C. DUNCAN, G. BADGER HUMPHRIES
Journal: Circulation (1973)

One hundred and forty patients with preinfarctional (unstable) angina were followed for ten years for the purpose of determining the natural history and the prognostic significance of electrocardiographic findings. The cumulative survival rate for the 140 patients was as follows: 12 months: 82%; 24 months: 75%; 36 months: 69%; 60 months: 61%; and 120 months: 48%. Twentyone percent (29 of 140) of the patients developed an acute myocardial infarction within eight months of the onset of the diagnosis of preinfarctional angina with an associated mortality of 41.4% (12 of 29). A combination of high-risk factors in a patient, e.g., frequent angina in the hospital, prior stable angina, and ischemic ST change during pain, identified his as a high-risk case. The high-risk subgroup (54) had a cumulative survival rate as follows: 12 months: 57%; 24 months: 47%; 36 months: 37%; 60 months: 27%; and 120 months: 19%. Thirty-five percent (19 of 54 patients) of this subgroup developed a myocardial infarction within three months of the onset of preinfarctional angina with an associated mortality rate of 63% (12 of 19 patients). At the first year follow-up, 18% (25 of 140) of the patients died; 74% (104 of 140) had less angina; and 8% (11 of 140) did not show a change in their anginal pattern. These data can be used as a basis for a controlled trial of surgical treatment for preinfarctional angina.
Time of Day Medicine Dose Is Taken May Boost Its Efficacy, Cut Toxicity
Authors: Lynne Lamberg
Journal: JAMA (1996)

WHEN A MEDICINE is given is as important as what medicine is given, according to speakers at an American Medical Association-sponsored media briefing, "Chronotherapeutics: Synchronizing Drug Therapies With Body Rhythms." The tenets of chronobiology—the study of biological rhythms—are still unfamiliar to most physicians, a recent Gallup poll shows. Chronobiologists say that predictable variations in bodily functions during the day, week, month, and year alter severity of disease symptoms, results of diagnostic tests, and effects of drugs and other therapy. Growing evidence that timed dosing substantially improves treatment outcomes will bring chronobiology into mainstream medical practice, speakers at the press briefing predicted. The 1-day session, held in New York City and funded by an educational grant from the Skokie, Ill—based pharmaceutical firm Searle, attracted more than 60 print and broadcast journalists. <h3>Behavioral and Circadian Rhythms</h3> In a Canadian study, for example, 118 children with acute lymphoblastic leukemia in remission took a
Gastric Carcinoma as a Small, Polyp-Like Lesion with Associated Benign Polyp
Authors: R. Ottenjann
Journal: Endoscopy (1970)

By means of radiology and endoscopy, two small antral polyps were found in a 58-year-old male. Whereas the macroscopic aspect was unsuspicous of malignancy, directed biopsy of the proximal polyp revealed carcinomatous structures. In the resected stomach lymphangiosis carcinomatosa of the submucous layers could also be demonstrated. Therefore, this type of carcinomatous lesion could not be classified as early carcinoma.
Evidence That Glutathione May Determine the Differential Cell-Cycle Phase Toxicity of a Platinum(IV) Antitumor Agent1
Authors: P. G. Edwards
Journal: JNCI Journal of the National Cancer Institute (1988)

Journal Article Evidence That Glutathione May Determine the Differential Cell-Cycle Phase Toxicity of a Platinum(IV) Antitumor Agent1 Get access Philippa G. Edwards Philippa G. Edwards 3Richard Dimbleby Department of Cancer Research, United Medical and Dental Schools, St. Thomas’ HospitalLondon SE1 7EH, England. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 80, Issue 10, 20 July 1988, Pages 734–738, https://doi.org/10.1093/jnci/80.10.734 Published: 20 July 1988 Article history Received: 14 March 1988 Accepted: 02 May 1988 Published: 20 July 1988
A STUDY OF THE CULTIVATION OF THE TUBERCLE BACILLUS DIRECTLY FROM THE SPUTUM BY THE METHOD OF PETROFF
Authors: Robert A. Keilty
Journal: The Journal of Experimental Medicine (1915)

1. Probably in the majority of cases it is possible, with scrupulous technique, to isolate the tubercle bacillus from contaminated material such as the sputum, by the method outlined by Petroff. 2. It is necessary to use several tubes. 3. Neutralization, drying, temperature of the incubator, and contamination after the growth has started are important points to be noted in the process. 4. The colonies start as pin points, becoming larger and confluent, but still preserving individual groups of a dry appearance which simulate the medium closely in color. 5. The bacillus of tuberculosis in young culture is tinctorially acid-fast and of a polymorphous morphology.
Allergy to diazepam--or vehicle.
Authors: O von Dardel, T Mossberg, C Mebius, B Svensson
Journal: BMJ (1977)

reported a rise of 22 beats/min after a similar dose in acute asthma, while we have shown a rise of 28 beats/min one minute after salbuta- mol 200 xjg injected over a one-minute period to convalescent asthmatics.5 Indeed, Mr Neville and his colleagues reported a rise of 31 beats/min on completion of their intravenous injection.It would seem likely that had Professor Femi-Pearse measured the pulse rate sooner after completion of the bolus injection of salbutamol a greater tachycardia would have been apparent.In view of these other reports we feel that salbutamol should be administered intravenously slowly (over at least five minutes) and that, with time, cardiotoxic effects or deaths will be observed if this effective bronchodilator is given rapidly as suggested.
Steroid side effects also seen in asthmatics
Authors: William A. Check
Journal: JAMA (1982)

Physicians using high doses of oral corticosteroids to treat asthmatic patients should be aware that two of the known side effects of these agents may occur in this group of patients as well: weakening of bones and development of posterior subcapsular cataracts.  In two recent separate studies of asthmatics taking 10 to 20 mg/day of prednisone, significant loss of trabecular bone and fractures were found in at least 10% of adults and initial cataractous changes in 30% of children. One investigative group reported preliminary findings that cataracts regressed when the children began using inhaled steroids.  Loss of Bone. —  At the Montreal meeting of the American Academy of Allergy and Immunology, Allen D. Adinoff, MD, described work that he undertook with Dwandolyn Reese and J. Roger Hollister, MD, at the National Jewish Hospital in Denver. From a retrospective examination of the records of 126 adult patients with asthma who were
In vivo characteristics of high, molecular weight copoly(l-lactide/glycolide) with S-type degradation pattern for application in drug delivery systems
Authors: Hironobu Fukuzaki, Masaru Yoshida, Masaharu Asano, Minoru Kumakura, Tooru Mashimo, Hisako Yuasa, Kyoichi Imai, Hidetoshi Yamanaka
Journal: Biomaterials (1991)
Progress in Device Technology
Authors: Victor Parsonnet
Journal: Circulation (1998)

A dvances in implantable device technology over the past few years can be seen in these illustrations.The photograph on the left shows a 1997-model implantable cardioverter-defibrillator (ICD) in front of an older version.Beside it is a modern single-chamber pacemaker in front of an older mercury-zinc-cell model.The Table shows their relative weights.These devices are now small enough to permit implantation of both in the same pectoral position, as shown in the photograph on the right.The implanted devices in this case were not the same as the one in the photograph but were of similar vintage.Tomorrow's dual-chamber pacemakers and ICDs will surely be contained in the same "can" and will be smaller still.
Alternative Pricing Strategies for Cancer Drugs—Reply
Authors: Peter B. Bach
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Long-term survival in multiple myeloma is associated with a distinct immunological profile, which includes proliferative cytotoxic T-cell clones and a favourable Treg/Th17 balance
Authors: C Bryant, H Suen, R Brown, S Yang, J Favaloro, E Aklilu, J Gibson, P J Ho, H Iland, P Fromm, N Woodland, N Nassif, D Hart, D E Joshua
Journal: Blood Cancer Journal (2013)

Despite improved outcomes in multiple myeloma (MM), a cure remains elusive. However, even before the current therapeutic era, 5% of patients survived >10 years and we propose that immune factors contribute to this longer survival. We identified patients attending our clinic, who had survived >10 years (n=20) and analysed their blood for the presence of T-cell clones, T-regulatory cells (Tregs) and T helper 17 (Th17) cells. These results were compared with MM patients with shorter follow-up and age-matched healthy control donors. The frequency of cytotoxic T-cell clonal expansions in patients with <10 years follow-up (MM patients) was 54% (n=144), whereas it was 100% (n=19/19) in the long-survivors (LTS-MM). T-cell clones from MM patients proliferated poorly in vitro, whereas those from LTS-MM patients proliferated readily (median proliferations 6.1% and 61.5%, respectively (P<0.0001)). In addition, we found significantly higher Th17 cells and lower Tregs in the LTS-MM group when compared with the MM group. These results indicate that long-term survival in MM is associated with a distinct immunological profile, which is consistent with decreased immune suppression.
Mosaic Dietary Laws
Authors: Leon Babalian
Journal: JAMA (1966)

To the Editor:—  Although Armenians consider themselves pure Caucasians, their resemblance to Jews is well known, as both groups frequently have the same physical features and same mental abilities. A partial common ancestry between them is related to the inhabitation of the center of Armenia by the Bagratid tribe, mostly of Hebrew origin, which finally settled in the Caucasian mountains.The medical news of The Journal( 197 , July 11, 1966 adv p 30) establishes more than  resemblance, as both have the same affinity for an inborn error of metabolism, the cause of the familial Mediterranean fever. There is no doubt in my mind that Jews and Armenians are genetically related.  The point I want to demonstrate is the questionable value of the Mosaic dietary laws. I am amazed to read even in medical literature ( JAMA  173 :323, 1960) that these laws were a sound program of preventive medicine, and
G-CSF treatment of severe congenital neutropenia reverses neutropenia but does not correct the underlying functional deficiency of the neutrophil in defending against microorganisms
Authors: Marta Donini, Stefania Fontana, Gianfranco Savoldi, William Vermi, Laura Tassone, Francesca Gentili, Elena Zenaro, Daniela Ferrari, Lucia D. Notarangelo, Fulvio Porta, Fabio Facchetti, Luigi D. Notarangelo, Stefano Dusi, Raffaele Badolato
Journal: Blood (2007)
Alcohol and Immune Defense
Authors: Rob Roy MacGregor
Journal: JAMA (1986)

THE INTEMPERATE use of alcoholic beverages is a serious problem for American society. In 1985 an estimated 10.6 million Americans were alcohol dependent, and 7.3 million more experienced some negative consequence of alcohol abuse such as arrest, accident, or impairment of health or job performance.<sup>1</sup>Alcohol is involved in 35% to 50% of marital violence cases and 10% of occupational injuries. In 1984 at least 18 500 traffic deaths (approximately 40% ) were alcohol related. The National Institute on Alcohol Abuse and Alcoholism estimated that alcoholrelated problems cost our society $117 billion in 1983. The impact on health includes increased morbidity from cirrhosis, gastrointestinal hemorrhage, trauma, cancer, and infection. Factors that contribute to the high incidence of infection among alcoholics include dulled mental function, breakdown of local protective barriers, aspiration, exposure, and malnutrition. Both malnutrition and cirrhosis of the liver are known to adversely affect the body's immune response, and so
Relations of lexical access to neural implementation and syntactic encoding
Authors: Willem J. M. Levelt, Antje S. Meyer, Ardi Roelofs
Journal: Behavioral and Brain Sciences (2004)

How can one conceive of the neuronal implementation of the processing model we proposed in our target article? In his commentary (Pulvermüller 1999, reprinted here in this issue), Pulvermüller makes various proposals concerning the underlying neural mechanisms and their potential localizations in the brain. These proposals demonstrate the compatibility of our processing model and current neuroscience. We add further evidence on details of localization based on a recent meta-analysis of neuroimaging studies of word production (Indefrey &amp; Levelt 2000). We also express some minor disagreements with respect to Pulvermüller's interpretation of the “lemma” notion, and concerning his neural modeling of phonological code retrieval. Branigan &amp; Pickering discuss important aspects of syntactic encoding, which was not the topic of the target article. We discuss their well-taken proposal that multiple syntactic frames for a single verb lemma are represented as independent nodes, which can be shared with other verbs, such as accounting for syntactic priming in speech production. We also discuss how, in principle, the alternative multiple-frame-multiple-lemma account can be tested empirically. The available evidence does not seem to support that account.
UN's Ins, Outs Affect US Military Medicine
Authors: Phil Gunby
Journal: JAMA (1995)

UNITED NATIONS (UN) actions in the days ahead—perhaps eventually leaving one troubled area while entering another—mean changes for US military medicine. Croatia, in what was Yugoslavia, is where the UN's long-term peacekeeping future is in doubt. The Croatian government originally asked UN peacekeepers to leave by June 30. Such a pullout could have included US Air Force physicians and other medical personnel who are the latest Americans to be operating the UN hospital at Zagreb (since February 15). Now, the Croatian government is working on a compromise with the UN that—for the time being—would allow a continued peacekeeper presence, although with fewer than half the present 12000 UN troops (including some US military members among the North Atlantic Treaty Organization [NATO] participants). What this will mean for the UN hospital at Zagreb remains to be seen. On the other hand, the UN is in the process of taking over the
Further Characterization of an Insulin Antagonist in the Serum of Patients in Diabetic Acidosis
Authors: James B. Field, Frank Tietze, Dewitt Stetten
Journal: Journal of Clinical Investigation (1957)

We have previously described an insulin antag- onist in the sera of patients in diabetic acidosis (1, 2).The protein nature of this material was suggested by its lability at 1000 C. and its electrophoretic migration with the a-globulins.The an- tagonist was not a lipoprotein and did not exhibit any insulinase activity.Its inhibitory effect was still demonstrable whether it was added to the hemidiaphragm preparation before or after ex- posure to insulin.Experiments using insulin-I'81 indicated that the antagonist did not compete with insulin for binding sites on diaphragm (2).Further characterization of this insulin antago- nist serves as the basis for this report.
Inhibition by Rifampin of the Anticoagulant Effect of Phenprocoumon
Authors: Ria J. Boekhout-Mussert
Journal: JAMA (1974)

THE strong antagonistic effect of rifampin on orally given anticoagulants is only indirectly referred to in the English literature.<sup>1</sup>We present two cases that illustrate this effect. <h3>Report of Cases</h3><h3>Case 1.—</h3> A 75-year-old man had been receiving long-term phenprocoumon (Marcoumar [Great Britain]; Liquamar, comparable US product) treatment (3 mg daily) for myocardial infarction since August 1970. In November 1971, treatment with rifampin, 600 mg, and isoniazid, 300 mg daily, for a suspected tuberculous spondylitis was begun. With the addition of these drugs, the patient's average phenprocoumon requirement increased to 6 mg/day. One year later after a severe gross hematuria, it was shown that his blood was incoagulable. Ten milligrams of phytonadione (Konakion) were given orally. The bleeding stopped, and therapeutic clotting values were restored and maintained with an average phenprocoumon dosage of 3 mg daily. On inquiry, it appeared that rifampin therapy had been discontinued three months before
Slave Doctors and Free Doctors — A Participant Observer Study of the Physician-Patient Relation in a Low-Income Comprehensive-Care Program
Authors: Margaret C. Heagarty, Leon S. Robertson
Journal: New England Journal of Medicine (1971)

Abstract Egalitarian comprehensive medical care implies that everyone should have a personal physician capable of diagnosing the overall social and emotional context of disease as well as the disease itself. The relation between middle-class physicians and lower-class patients is a drama in which staging can be blocked out by the lack of understanding of the conditions of poverty by the physicians, limited resources for communication by the patient and misunderstanding of the meaning of manipulative actions by both. The physician oriented to "interesting disease" misses the meaning of most cues, and only after considerable prompting, do a few learn the real plot. The idealistic physician is judgmental in his approach to fellow professionals and patients, and he too, if he does not give up in disgust, requires prompting and experience before his role is fitted to the realities and needs of the other players. A repertory company, rather than a single play including only the physician and the poor, seems advisable if the players are to carry out their roles effectively.
RADIATION SERVICE IN THE MODERN HOSPITAL
Authors: ALBERT SOILAND
Journal: JAMA (1930)

With the passing of the nineteenth century came a distinct change in science and its applications, which had a profound effect on medicine. Although the discoveries of Roentgen and the Curies were purely physical, the practical side of their work has been largely medical, affording not only diagnostic but also therapeutic aid. So general has the acceptance of this aid been that there is now a distinct branch of medicine devoted to radiant energy under the caption of radiology. It is only natural that in the entering of new fields many disappointments and failures should have resulted. These have come from faulty technic interpretation or application; nevertheless, improvement has steadily taken place, so that we now have a more definite idea as to the place x-rays and radium should occupy in our diagnostic and therapeutic armamentarium. In modern hospitals there has been an endeavor to increase radiologic efficiency, and it