tbuckley/cabot-search huggingface dataset:
Management of depression in UK general practice in relation to scores on depression severity questionnaires: analysis of medical record data
Authors: T. Kendrick, C. Dowrick, A. McBride, A. Howe, P. Clarke, S. Maisey, M. Moore, P. W Smith
Journal: BMJ (2009)

<b>Objective</b> To determine if general practitioner rates of antidepressant drug prescribing and referrals to specialist services for depression vary in line with patients’ scores on depression severity questionnaires. <b>Design</b> Analysis of anonymised medical record data. <b>Setting</b> 38 general practices in three sites—Southampton, Liverpool, and Norfolk. <b>Data reviewed</b> Records for 2294 patients assessed with severity questionnaires for depression between April 2006 and March 2007 inclusive. <b>Main outcome measures</b> Rates of prescribing of antidepressants and referrals to specialist mental health or social services. <b>Results</b> 1658 patients were assessed with the 9 item patient health questionnaire (PHQ-9), 584 with the depression subscale of the hospital anxiety and depression scale (HADS), and 52 with the Beck depression inventory, 2nd edition (BDI-II). Overall, 79.1% of patients assessed with either PHQ-9 or HADS received a prescription for an antidepressant, and 22.8% were referred to specialist services. Prescriptions and referrals were significantly associated with higher severity scores. However, overall rates of treatment and referral were similar for patients assessed with either measure despite the fact that, with PHQ-9, 83.5% of patients were classified as moderately to severely depressed and in need of treatment, whereas only 55.6% of patients were so classified with HADS. Rates of treatment were lower for older patients and for patients with comorbid physical illness (including coronary heart disease and diabetes) despite the fact that screening for depression among such patients is encouraged in the quality and outcomes framework. <b>Conclusions </b>General practitioners do not decide on drug treatment or referral for depression on the basis of questionnaire scores alone, but also take account of other factors such as age and physical illness. The two most widely used severity questionnaires perform inconsistently in practice, suggesting that changing the recommended threshold scores for intervention might make the measures more valid, more consistent with practitioners’ clinical judgment, and more acceptable to practitioners as a way of classifying patients.
Fractionated radiotherapy of lentigo maligna and lentigo maligna melanoma in 64 patients
Authors: M.H. Schmid-Wendtner, B. Brunner, B. Konz, P. Kaudewitz, C.M. Wendtner, R.U. Peter, G. Plewig, M. Volkenandt
Journal: Journal of the American Academy of Dermatology (2000)
jModelTest: Phylogenetic Model Averaging
Authors: D. Posada
Journal: Molecular Biology and Evolution (2008)

jModelTest is a new program for the statistical selection of models of nucleotide substitution based on "Phyml" (Guindon and Gascuel 2003. A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood. Syst Biol. 52:696–704.). It implements 5 different selection strategies, including "hierarchical and dynamical likelihood ratio tests," the "Akaike information criterion," the "Bayesian information criterion," and a "decision-theoretic performance-based" approach. This program also calculates the relative importance and model-averaged estimates of substitution parameters, including a model-averaged estimate of the phylogeny. jModelTest is written in Java and runs under Mac OSX, Windows, and Unix systems with a Java Runtime Environment installed. The program, including documentation, can be freely downloaded from the software section at http://darwin.uvigo.es.
Urine Albumin-to-Creatinine Ratio
Authors: Bryan Kestenbaum, Ian H. de Boer
Journal: Journal of the American Society of Nephrology (2010)

The evaluation of urinary protein is a cornerstone for the diagnosis and treatment of kidney disease. Quantification of proteinuria is used to inform fundamental clinical decisions, such as whether to refer to a nephrologist, perform a kidney biopsy, or initiate therapy. Furthermore, minute interindividual differences in proteinuria associate with future risks for heart disease, kidney failure, and cancer in general population studies.1–3 These findings motivate optimal and consistent methods to quantify proteinuria in the clinical setting.

In this issue of JASN , Heerspink et al. 4 compare, among 701 participants in the Reduction In Endpoints in Noninsulin Dependent Diabetes Mellitus with the Angiotensin-II Antagonist Losartan (RENAAL) trial, four standard methods for measuring urine protein: 24-hour urine protein excretion, 24-hour urine albumin excretion, first morning void spot urine albumin concentration, and first morning void spot urine albumin-to-creatinine ratio (ACR). Unlike most previous studies, which related spot urine albumin or urine protein measurements to the gold standard, 24-hour urine collection, the study by Heerspink et al. 4 addresses which of the four methods most strongly associates with the clinical outcome of …
Multicenter Phase I/II Study of Cetuximab With Paclitaxel and Carboplatin in Untreated Patients With Stage IV Non–Small-Cell Lung Cancer
Authors: Christiane D. Thienelt, Paul A. Bunn, Nasser Hanna, Arthur Rosenberg, Michael N. Needle, Michael E. Long, Daniel L. Gustafson, Karen Kelly
Journal: Journal of Clinical Oncology (2005)

Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors have demonstrated antitumor activity in patients with non-small-cell lung cancer (NSCLC). This study examined the safety profile of the monoclonal antibody EGFR inhibitor, cetuximab, when added to paclitaxel and carboplatin in untreated patients with stage IV NSCLC. Secondary objectives included efficacy and paclitaxel and carboplatin pharmacokinetics during cetuximab treatment.Patients with tumor evidence of EGFR by immunohistochemistry, performance status of 0 to 2, and measurable disease received paclitaxel 225 mg/m2 with carboplatin area under the curve = 6 on day 1 every 3 weeks. Cetuximab was administered at 400 mg/m2, 1 week before paclitaxel and carboplatin, then weekly at 250 mg/m2. The regimen continued until disease progression or intolerable toxicity.Thirty-one of 32 enrolled patients were treated. The most common cetuximab toxicity was rash in 84% of patients (grade 3 in 13%). Pharmacokinetic sampling did not reveal an interaction between carboplatin, paclitaxel, and cetuximab. An objective response was observed in eight patients (26%). With a median follow-up of 19 months, the median time to progression was 5 months, median survival was 11 months, and the 1- and 2-year survival rates were 40% and 16%, respectively.The combination of cetuximab, paclitaxel, and carboplatin was safe and well tolerated in this population of stage IV patients. The response rate, time to progression, and median survival were slightly superior to historical controls treated with paclitaxel and carboplatin alone. A randomized phase II trial has completed accrual.
Supravenous discoloration of the skin due to docetaxel treatment
Authors: D. Schrijvers, J. Van Den Brande, J.B. Vermorken
Journal: British Journal of Dermatology (2000)

Journal Article Supravenous discoloration of the skin due to docetaxel treatment Get access D. Schrijvers, D. Schrijvers Search for other works by this author on: Oxford Academic Google Scholar J. Van Den Brande, J. Van Den Brande Search for other works by this author on: Oxford Academic Google Scholar J.B. Vermorken J.B. Vermorken Department of Medical Oncology, University Hospital Antwerp, Wilrijkstraat 10, B‐2650 Edegem, Belgium E‐mail: dirk.schrijvers@uza.uia.ac.be Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 142, Issue 5, 1 May 2000, Pages 1069–1070, https://doi.org/10.1046/j.1365-2133.2000.03518.x Published: 01 May 2000
Response to Letter Regarding Article, “Patient Characteristics and Cell Source Determine the Number of Isolated Human Cardiac Progenitor Cells”
Authors: Ayelet Itzhaki-Alfia, Jonathan Leor, Shiri Netser, Radka Holbova, Israel M. Barbash, Ehud Raanani, Leonid Sternik, Dan Spiegelstein, Jacob Lavee, Meirav Pevsner-Fischer
Journal: Circulation (2010)
α-Amylase, a flour additive: An important cause of protein contact dermatitis in bakers
Authors: Marie-Anne Morren, Veronique Janssens, An Dooms-Goossens, Erna Van Hoeyveld, Ann Cornelis, Christiane De Wolf-Peeters, Annie Heremans
Journal: Journal of the American Academy of Dermatology (1993)
Metabolic syndrome and visceral obesity as risk factors for reflux oesophagitis: a cross-sectional case-control study of 7078 Koreans undergoing health check-ups
Authors: S J Chung, D Kim, M J Park, Y S Kim, J S Kim, H C Jung, I S Song
Journal: Gut (2008)

Obesity has been associated with reflux oesophagitis. However, the relationship between metabolic syndrome characterised by visceral obesity and reflux oesophagitis is unclear.To investigate whether metabolic syndrome or visceral obesity is a risk factor for reflux oesophagitis.A cross-sectional study of 7078 subjects undergoing upper endoscopy during health check-ups was conducted (3539 patients with reflux oesophagitis vs age- and sex-matched controls). We further analysed according to categories of visceral adipose tissue and subcutaneous adipose tissue area with 750 cases and age-, sex- and waist circumference-matched controls who underwent abdominal CT scan.The prevalence of metabolic syndrome was higher in cases than controls (26.9% vs 18.5%, p<0.001). Multivariate analysis demonstrated that metabolic syndrome is associated with reflux oesophagitis (odds ratio (OR) = 1.42; 95% confidence interval (CI), 1.26 to 1.60). Among the individual components of metabolic syndrome, waist circumference (OR = 1.47; 95% CI, 1.30 to 1.65) and triglyceride (OR = 1.20; 95% CI, 1.05 to 1.36) independently increased the risk for reflux oesophagitis. On sub-analysis, cases showed higher mean visceral adipose tissue area (cm(2)) (136.1 (SD 57.8) vs 124.0 (SD 54.7), p<0.001) and subcutaneous adipose tissue area (cm(2)) (145.9 (SD 56.8) vs 133.5 (SD 50.7), p<0.001). However, only visceral adipose tissue area was an independent risk factor for reflux oesophagitis after adjusting for multiple confounders including smoking, alcohol, body mass index (BMI) and subcutaneous adipose tissue area (OR = 1.60; 95% CI, 1.03 to 2.48, lowest quartile vs highest quartile).Metabolic syndrome was associated with reflux oesophagitis. Abdominal obesity, especially visceral obesity, was an important risk factor for reflux oesophagitis.
Sustained activation and tumor targeting of NKT cells using a CD1d–anti-HER2–scFv fusion protein induce antitumor effects in mice
Authors: Kathrin Stirnemann, Jackeline F. Romero, Lucia Baldi, Bruno Robert, Valérie Cesson, Gurdyal S. Besra, Maurice Zauderer, Florian Wurm, Giampietro Corradin, Jean-Pierre Mach, H. Robson MacDonald, Alena Donda
Journal: Journal of Clinical Investigation (2008)

Invariant NKT (iNKT) cells are potent activators of DCs, NK cells, and T cells, and their antitumor activity has been well demonstrated. A single injection of the high-affinity CD1d ligand alpha-galactosylceramide (alphaGalCer) leads to short-lived iNKT cell activation followed, however, by long-term anergy, limiting its therapeutic use. In contrast, we demonstrated here that when alphaGalCer was loaded on a recombinant soluble CD1d molecule (alphaGalCer/sCD1d), repeated injections led to sustained iNKT and NK cell activation associated with IFN-gamma secretion as well as DC maturation in mice. Most importantly, when alphaGalCer/sCD1d was fused to a HER2-specific scFv antibody fragment, potent inhibition of experimental lung metastasis and established s.c. tumors was obtained when systemic treatment was started 2-7 days after the injection of HER2-expressing B16 melanoma cells. In contrast, administration of free alphaGalCer at this time had no effect. The antitumor activity of the CD1d-anti-HER2 fusion protein was associated with HER2-specific tumor localization and accumulation of iNKT, NK, and T cells at the tumor site. Targeting iNKT cells to the tumor site thus may activate a combined innate and adaptive immune response that may prove to be effective in cancer immunotherapy.
The ‘impact’ of force filtering cut-off frequency on the peak knee abduction moment during landing: artefact or ‘artifiction’?
Authors: Benjamin D Roewer, Kevin R Ford, Gregory D Myer, Timothy E Hewett
Journal: British Journal of Sports Medicine (2012)

Background Joint moments computed using inverse dynamic techniques are important estimators of net joint loads. Joints moments computed from marker position and ground reaction force data filtered using different cut-off frequencies may capture changes in moment magnitudes at a single joint that exceed normal physiological response. Peak external knee abduction moment (KAM) generated during landing (ie, the drop vertical jump, DVJ) predicts anterior cruciate ligament injury risk using marker and force data filtered at different cut-off frequencies. The purpose of the current investigation was to determine the effects of using the same low cut-off frequencies versus different cut-off frequencies on joint moment magnitudes to evaluate if artificial smoothing attenuates actual resultant joint loads related to injury risk. Methods Twenty-two female, high school volleyball players performed three maximum DVJs in a laboratory setting. The average peak KAM was computed for each knee using marker and force data filtered with the same low cut-off frequencies and different cut-off frequencies. Results Peak KAMs were significantly larger using different cut-off frequencies. The order of athletes ranked based on the magnitude of their peak KAMs did not significantly change across all filtering cut-off frequencies. Conclusions The magnitude of peak KAM may differ when the same low or different higher cut-off frequencies are used to filter marker and ground reaction forces (GRF) data collected using standard motion capture equipment. It is not clear to what extent the decrease in peak KAM reported when the same low cut-off frequencies were used was solely due to attenuation of the GRF signal.
Anomalous origin of the left coronary artery from the pulmonary artery with coronary artery steal in adults. Report of two cases and review of the literature.
Authors: F N Ihekwaba, K G Davidson, B Ogilvie, P K Caves
Journal: Thorax (1976)

Patients with anomalous left coronary artery arising from the pulmonary artery rarely survive to adult life. Those who attain adulthood may present with angina indistinguishable from coronary artery disease and are liable to sudden death. Myocardial infarction, though rare in young adults, may occur and may be due to coronary artery steal. Accurate diagnosis requires coronary arteriography. Two further cases of coronary artery steal in adults with anomalous origin of the left coronary artery from the pulmonary artery are presented. In both patients aortocoronary bypass grafting using a reversed autogenous saphenous vein with closure of the origin of the anomalous left coronary artery was successfully performed. This operation provided complete symptomatic relief and may protect patients against the risk of sudden death.
Expression of the obesity hormone leptin and its receptor correlates with hypoxia-inducible factor-1α in human colorectal cancer
Authors: M. Koda, M. Sulkowska, L. Kanczuga-Koda, S. Cascio, G. Colucci, A. Russo, E. Surmacz, S. Sulkowski
Journal: Annals of Oncology (2007)
Viruses and bacteria in acute asthma exacerbations – A GA<sup>2</sup>LEN‐DARE* systematic review
Authors: N. G. Papadopoulos, I. Christodoulou, G. Rohde, I. Agache, C. Almqvist, A. Bruno, S. Bonini, L. Bont, A. Bossios, J. Bousquet, F. Braido, G. Brusselle, G. W. Canonica, K. H. Carlsen, P. Chanez, W. J. Fokkens, M. Garcia‐Garcia, M. Gjomarkaj, T. Haahtela, S. T. Holgate, S. L. Johnston, G. Konstantinou, M. Kowalski, A. Lewandowska‐Polak, K. Lødrup‐Carlsen, M. Mäkelä, I. Malkusova, J. Mullol, A. Nieto, E. Eller, C. Ozdemir, P. Panzner, T. Popov, S. Psarras, E. Roumpedaki, M. Rukhadze, A. Stipic‐Markovic, A. Todo Bom, E. Toskala, P. van Cauwenberge, C. van Drunen, J. B. Watelet, M. Xatzipsalti, P. Xepapadaki, T. Zuberbier
Journal: Allergy (2010)

To cite this article: Papadopoulos NG, Christodoulou I, Rohde G, Agache I, Almqvist C, Bruno A, Bonini S, Bont L, Bossios A, Bousquet J, Braido F, Brusselle G, Canonica GW, Carlsen KH, Chanez P, Fokkens WJ, Garcia‐Garcia M, Gjomarkaj M, Haahtela T, Holgate ST, Johnston SL, Konstantinou G, Kowalski M, Lewandowska‐Polak A, Lødrup‐Carlsen K, Mäkelä M, Malkusova I, Mullol J, Nieto A, Eller E, Ozdemir C, Panzner P, Popov T, Psarras S, Roumpedaki E, Rukhadze M, Stipic‐Markovic A, Todo Bom A, Toskala E, van Cauwenberge P, van Drunen C, Watelet JB, Xatzipsalti M, Xepapadaki P, Zuberbier T. Viruses and bacteria in acute asthma exacerbations – A GA 2 LEN‐DARE systematic review. Allergy 2011; 66 : 458–468. Abstract A major part of the burden of asthma is caused by acute exacerbations. Exacerbations have been strongly and consistently associated with respiratory infections. Respiratory viruses and bacteria are therefore possible treatment targets. To have a reasonable estimate of the burden of disease induced by such infectious agents on asthmatic patients, it is necessary to understand their nature and be able to identify them in clinical samples by employing accurate and sensitive methodologies. This systematic review summarizes current knowledge and developments in infection epidemiology of acute asthma in children and adults, describing the known impact for each individual agent and highlighting knowledge gaps. Among infectious agents, human rhinoviruses are the most prevalent in regard to asthma exacerbations. The newly identified type‐C rhinoviruses may prove to be particularly relevant. Respiratory syncytial virus and metapneumovirus are important in infants, while influenza viruses seem to induce severe exacerbations mostly in adults. Other agents are relatively less or not clearly associated. Mycoplasma and Chlamydophila pneumoniae seem to be involved more with asthma persistence rather than with disease exacerbations. Recent data suggest that common bacteria may also be involved, but this should be confirmed. Although current information is considerable, improvements in detection methodologies, as well as the wide variation in respect to location, time and populations, underline the need for additional studies that should also take into account interacting factors.
The Formation of Lymphatic Vessels and Its Importance in the Setting of Malignancy
Authors: Michael Detmar, Satoshi Hirakawa
Journal: The Journal of Experimental Medicine (2002)

The lymphatic vascular system plays important roles in the maintenance of tissue fluid homeostasis, in the mediation of the afferent immune response, and in the metastatic spread of malignant tumors to regional lymph nodes. It consists of a dense network of blind ending, thin-walled lymphatic capillaries and collecting lymphatics that drain extravasated protein-rich fluid from most organs and transport the lymph via the thoracic duct to the venous circulation (1). Originally discovered as “milky veins” by Gasparo Aselli in the 17th century (2), the mechanisms controlling the normal development of lymphatic vessels and the molecular regulation of their biological function have remained poorly understood in contrast to the rapid progress made in elucidating the formation and molecular control of the blood vascular system (3, 4).
Identification of the Genes for Kidney Cancer: Opportunity for Disease-Specific Targeted Therapeutics
Authors: W. Marston Linehan, Peter A. Pinto, Ramaprasad Srinivasan, Maria Merino, Peter Choyke, Lynda Choyke, Jonathan Coleman, Jorge Toro, Gladys Glenn, Cathy Vocke, Bert Zbar, Laura S. Schmidt, Donald Bottaro, Len Neckers
Journal: Clinical Cancer Research (2007)

Abstract Recent advances in understanding the kidney cancer gene pathways has provided the foundation for the development of targeted therapeutic approaches for patients with this disease. Kidney cancer is not a single disease; it includes a number of different types of renal cancers, each with different histologic features, a different clinical course, a different response to therapy, and different genes causing the defects. Most of what is known about the genetic basis of kidney cancer has been learned from study of the inherited forms of kidney cancer: von Hippel Lindau (VHL gene), hereditary papillary renal carcinoma (c-Met gene), Birt Hogg Dubé (BHD gene), and hereditary leiomyomatosis renal cell cancer (fumarate hydratase gene). These Mendelian single-gene syndromes provide a unique opportunity to evaluate the effectiveness of agents that target the VHL, c-Met, BHD, and fumarate hydratase pathways.
Epidemiology of football fractures in the adult Lothian population
Authors: A M Wood, S A Aitken, D J Bell, G A J Robertson, C M Court-Brown
Journal: British Journal of Sports Medicine (2010)

The aim was to illustrate the incidence and epidemiology of fractures sustained by adults while participating in football. All fractures during 2007-2008 in the Lothian population while participating in football were prospectively collected. 412 footballers (400 males) sustained 424 fractures. The incidence was 6.1/10 000 fractures/years. The average age was 25 (range 12-76) years. 56 (14%) patients were over 40 years. Two (0.5%) open fractures were sustained, on digits. The top five fractures were: radius (108), phalanges (72), ankle fractures (44), metacarpals (29), metatarsals (28). Upper limb to lower limb ratio was 290:136. 143 fractures were in the hand, with four isolated ulna fractures. 16 were fracture dislocations, nine involving the phalanges, five the ankle mortice. 360 fractures were initially treated as outpatients, 18 required admission from clinic and 64 fractures were admitted from A&amp;E. Two patients were professional footballers. Football is the most common cause of sport fractures. While the epidemiology of football fractures will vary as participation varies, the authors believe these results are useful for medical teams involved with football. As the ageing population is actively encouraged to participate in sport there will be increasing numbers of osteoporotic fractures sustained. The authors demonstrated that football fractures are not limited to the young; 13.6% of patients were over 40 years. Upper limb fractures are more common as footballers are likely to sustain fractures after a fall rather than contact injuries. 60% of fractures were sustained below the elbow with only four isolated ulna fractures, probably secondary to direct trauma. Most fractures were closed injuries; no open long bone fractures were seen. Pitch-side practitioners should be aware that 10% of ankle fractures were dislocated with the potential for neurovascular complications. Most patients can be discharged from Accident and Emergency and managed as outpatients, a fifth required inpatient treatment. Most patients were not employed as footballers reflecting participation from all ages and occupations. Football produces significant number of fractures in the general population. Most are closed, sustained below the elbow, and can be managed in the outpatient setting.
Test of Four Colon Cancer Risk-Scores in Formalin Fixed Paraffin Embedded Microarray Gene Expression Data
Authors: Antonio F. Di Narzo, Sabine Tejpar, Simona Rossi, Pu Yan, Vlad Popovici, Pratyaksha Wirapati, Eva Budinska, Tao Xie, Heather Estrella, Adam Pavlicek, Mao Mao, Eric Martin, Weinrich Scott, Fred T. Bosman, Arnaud Roth, Mauro Delorenzi
Journal: JNCI Journal of the National Cancer Institute (2014)

BackgroundPrognosis prediction for resected primary colon cancer is based on the T-stage Node Metastasis (TNM) staging system. We investigated if four well-documented gene expression risk scores can improve patient stratification.