Therapy of Cushing Disease: A Consensus for Pituitary Microsurgery
Authors: James C. Melby
Journal: Annals of Internal Medicine (1988)

Editorials15 September 1988Therapy of Cushing Disease: A Consensus for Pituitary MicrosurgeryJames C. Melby, MDJames C. Melby, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-6-445 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTranssphenoidal pituitary adenomectomy has emerged as the primary treatment of choice for Cushing disease. The overall cure rate of histologically proved pituitary tumors approaches 90% in the hands of skilled neurosurgeons as has been shown in the major series of 221 patients described by Mampalam and colleagues (1) in this issue. The remarkable success of this procedure has also been observed in 91% of 228 patients studied at the Mayo Clinic over the past 11 years (2; Laws EJ. Personal communication). When no pituitary adenoma can be found histologically the cure rate falls to slightly less than 60%. Extrasellar extension...References1. 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Schrell U, Fahlbusch R, Buchfelder M, Riedl S, Stalla G, and Müller O. Corticotropin-releasing hormone stimulation test before and after transsphenoidal selective microadenomectomy in 30 patients with Cushing's disease. J Clin Endocrinol Metab. 1987;64:1150-9. CrossrefMedlineGoogle Scholar12. Styne D, Grumbach M, Kaplan S, Wilson C, and Conte F. Treatment of Cushing's disease in childhood and adolescence by transsphenoidal microadenomectomy. N Engl J Med. 1984;310:889-93. CrossrefMedlineGoogle Scholar13. Kjellberg R, Bliman B, Swisher B, and Butler B. Proton beam therapy of Cushing's disease and Nelson's syndrome. In: Black PM, et al. Secretory Tumors of the Pituitary Gland. New York:Raven Press;1984:295. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: James C. Melby, MDAffiliations: University Hospital Boston University Medical Center Boston, MA 02118 Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMeasurement of the normal feline pituitary gland in brachycephalic and mesocephalic catsPituitary and Pituitary Region Tumors: Viewpoint—Fractionated Radiation TherapyCanine HyperadrenocorticismHyperadrenocorticism in CatsEndocrine, Metabolic, and Nutritional DiseasesExpression and Functional Analysis of Dopamine Receptor Subtype 2 and Somatostatin Receptor Subtypes in Canine Cushing's DiseaseRole for postoperative cortisol response to desmopressin in predicting the risk for recurrent Cushing's diseasePituitary and Pituitary Region Tumors: Fractionated Radiation Therapy PerspectiveProspective evaluation of transsphenoidal pituitary surgery in 108 patients with Cushing's diseaseComparative dermatology—canine endocrine dermatosesLong-term remission rates after pituitary surgery for Cushing's disease: the need for long-term surveillanceEfficacy of Transsphenoidal Hypophysectomy in Treatment of Dogs with Pituitary-Dependent HyperadrenocorticismAcquired prolactin deficiency (APD) after treatment for Cushing's disease is a reliable marker of irreversible severe GHD but does not reflect disease statusTranssphenoidal surgery in Cushing disease: 10 years of experience in 34 consecutive casesDynamic Computed Tomography of the Pituitary Gland in Dogs with Pituitary-Dependent HyperadrenocorticismNeurosurgical Treatment of Nelson's SyndromeProgress in transsphenoidal hypophysectomy for treatment of pituitary-dependent hyperadrenocorticism in dogs and catsCushing's DiseaseHypophysectomy as a Treatment for Canine and Feline Cushing's DiseaseTranssphenoidal pituitary surgery in Cushing's disease: can we predict outcome?Transsphenoidal hypophysectomy for treatment of pituitary-dependent hyperadrenocorticism in 7 catsLa enfermedad de Cushing en los años 90. 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Kaye, MD, Lawrence Crapo, MDCushing's disease: results of transsphenoidal microsurgery with emphasis on surgical failuresCushing's SyndromePituitary Tumors 15 September 1988Volume 109, Issue 6Page: 445-446KeywordsFallsNeurosurgeryPituitary tumors ePublished: 1 December 2008 Issue Published: 15 September 1988 PDF downloadLoading ...