tbuckley/cabot-search huggingface dataset:
Administration of Radiographic Contrast Medium After a Prior Adverse Reaction
Authors: Roy Patterson, Michael Schatz
Journal: Annals of Internal Medicine (1975)

Editorials1 August 1975Administration of Radiographic Contrast Medium After a Prior Adverse ReactionROY PATTERSON, M.D., F.A.C.P., MICHAEL SCHATZ, M.D.ROY PATTERSON, M.D., F.A.C.P.Search for more papers by this author, MICHAEL SCHATZ, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-83-2-277 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptReadministration of a diagnostic or therapeutic agent to a patient with a history of an adverse reaction to that agent may have grave medical and medicolegal consequences. Nonetheless, it is in the patient's best interest under certain circumstances to do this when the potential value of the agent exceeds the potential risk of readministration of the agent. An example of current importance is the administration of a radiographic contrast medium. Reaction to radiographic contrast media is a special case among immediate-type drug reactions because no adequate substitutes for them exist, such reactions have not been shown to be IgE mediated,...References1. FISCHERDOUST HV: An evaluation of pretesting in the problem of serious and fatal reactions to excretory urography. Radiology 103:497-501, 1972 CrossrefMedlineGoogle Scholar2. ZWEIMANMISHKINHILDRETH BME: An approach to the performance of contrast studies in contrast material-reactive persons. Ann Intern Med 83:159-162, 1975 LinkGoogle Scholar3. SCHATZPATTERSONO'ROURKE MRJ: The administration of radiographic contrast media to patients with a history of a previous reaction. J Allergy Clin Immunol 55:358-366, 1975 CrossrefMedlineGoogle Scholar4. OCHSNERCALONJE SM: Reactions to intravenous iodines in urography. South Med J 64:907-911, 1971 CrossrefMedlineGoogle Scholar5. WITTENHIRSCHHARTMAN DFG: Acute reactions to urographic contrast medium: incidence, clinical characteristics and relationship to history of hypersensitivity states. Am J Roentgenol Radium Ther Nucl Med 119:832-840, 1973 CrossrefMedlineGoogle Scholar6. MILLERDOPPMANKAPLAN WJA: Renal arteriography following systemic reaction to contrast material. J Allergy Clin Immunol, in press Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROY PATTERSON, M.D., F.A.C.P.; MICHAEL SCHATZ, M.D.Affiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byProminent facial edema caused by potassium iodide solution in a patient with sporotrichosisRisk of severe allergic reactions from the use of potassium iodide for radiation emergenciesH1- and H2-antagonists in allergic and pseudoallergic diseasesAnaphylactoid reaction to angiographic contrast media: Recurrence despite pretreatment with corticosteroids 1 August 1975Volume 83, Issue 2Page: 277-277KeywordsAdverse reactionsDrugs ePublished: 1 December 2008 Issue Published: 1 August 1975 PDF downloadLoading ...
Imaging of a Thymoma Incidentally Detected by C-11 Choline PET/CT
Authors: Federico Fallanca, Maria Picchio, Elena Giulia Spinapolice, Clara Ugolini, Agnese Proietti, Cristina Messa
Journal: Clinical Nuclear Medicine (2011)

The integrated modality positron emission tomography/computed tomography (PET/CT) with C-11 choline is an established diagnostic tool for restaging prostate cancer patients with a biochemical failure after primary treatment. Thymoma is a rare tumor originating in thymus epithelial cells, asymptomatic in one-third to one-half of patients, and often occurring in the fourth and fifth decades of life. In the present case, C-11 choline PET/CT was performed in a prostate cancer patient with a biochemical relapse, to restage the disease. In addition to the detection of local recurrent disease in prostatic fossa, an abnormal C-11 choline increased uptake in mediastinum was reported. The mediastinal finding was initially wrongly interpreted by clinicians as a lymph nodal metastasis from prostate cancer. However, histopathological analysis confirmed the presence of a thymoma. Although rare, thymoma has to be considered as differential diagnosis in case of mediastinal masses presenting C-11 choline PET/CT positive findings, to avoid inappropriate patient management.
Antibiotic Prophylaxis for Cardiovascular Surgery
Authors: R. PLATT
Journal: Annals of Internal Medicine (1984)

Two hundred twenty patients were randomly assigned to receive either ceforanide or cephalothin as perioperative antibiotic prophylaxis during cardiovascular surgery. More infections were seen among cephalothin recipients (8 deep, 32 total) than among ceforanide recipients (1 deep, 17 total). Among patients who had only coronary artery bypass grafting, more cephalothin recipients had infection than did ceforanide recipients (19 of 82 as opposed to 7 of 83;p=0.001; relative risk, 2.7; 95% confidence interval, 1.22 to 6.18). The difference between the two regimens was attributable to fewer blood, wound, and urinary tract infections. Among patients who had other procedures, there was no difference in the efficacy of the two regimens. Cephalothin recipients who developed wound or blood stream infections had lower antibiotic levels in their atrial appendages than recipients not developing such infections (p=0.02). If one assumes that cephalothin does not increase the risk of infection, then these data show that antibiotic prophylaxis prevents infection after coronary artery bypass surgery, and, in the dosages used, that ceforanide is superior to cephalothin.
INDUCTION OF ARTERIAL HYPERTENSION IN NORMAL AND ADRENALECTOMIZED RATS GIVEN CORTISONE ACETATE
Authors: Abbie I. Knowlton, Emily N. Loeb, Herbert C. Stoerk, Joseph P. White, John F. Heffernan
Journal: The Journal of Experimental Medicine (1952)

1. Marked hypertension was induced in adrenalectomized rats on a sodium-restricted intake by the administration of cortisone acetate; on a similar regimen, adrenalectomized rats receiving DCA failed to become hypertensive. 2. The incorporation of a liberal amount of sodium in the diet of adrenalectomized rats receiving cortisone acetate resulted in a lesser degree of hypertension; whereas on a similar regimen, DCA-injected animals became strikingly hypertensive, as has been previously reported. 3. The presence of hypertension in the cortisone acetate-treated rats was not associated with histological evidence of renal damage or serum electrolyte disturbance, such as was observed in hypertensive animals receiving DCA. 4. The hypertension in sodium-restricted normal rats receiving cortisone acetate was less striking than in similarly treated adrenalectomized animals. On a liberal sodium intake similar degrees of hypertension were noted in both intact and adrenalectomized groups. 5. To approximate the loss of weight which occurred in cortisone acetate-injected rats, it was necessary to curtail the food intake of partially fasted control groups to 50 to 75 per cent of the amount consumed by the animals receiving the steroid. 6. The serum cholesterol levels of the cortisone acetate-injected rats were consistently and strikingly elevated as contrasted with normal, partially fasted, or DCA-treated animals.
Could Behavioral Medicine Lead the Web Data Revolution?
Authors: John W. Ayers, Benjamin M. Althouse, Mark Dredze
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Association for Patient-Oriented Research
Authors: M. J. Friedrich
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
NOTE ON THE INCIDENCE OF TETANUS AMONG WOUNDED SOLDIERS
Authors: D. Bruce
Journal: BMJ (1917)

pradf1lly developin)g, anid the general nuLtrition-of the hand showtd improvement.There was slight power of grasp and onine power of fiexion in the wrist, as well as slight power of adductiou of the thumb and flexion of the fingers.Senisationi was felt all over thie thumb and index finger, in thje second finiger up to the first phalanx oni the palmar aspect, also in the third finger, though less distinct.No sensation could be elicited over the distributioni of the ulnar nerve.Un March 30th he betan to have sharp shooting paitns along the distribution of the Llnar nerve.(in April 1st the flexors of tl,e forearm began to react visibly to C.C.C., though the muscles ol the thenar eminienice did not, and there was no faradic reactioni.On April 30th sensation was returninlg at the back of the ring finger, and the flexors now reacted to A.C.C. of mimlliainp res.un Jtune 13tlh the nutrition of the hand was much improved, and there was a greater feeling of warmthi in it.lie could pick tip small objects.and(l although) the grasp was not powerful, it was much improvedt.The powers of flexioni of the wrist and a(lduction of the thumnb were considerably iniereased, buit there was no sensation as yet over the uluar distribution.Condition of the Patient Six Years after Operation.Being interested in the case, I made inquiries from time to time after he left Leeds, but I niever saw kim againi ulntil lebcuary, 1896, six years after the operation, whenl I asked him if nie would let me demonstrate his case at the Leeds aLtd West hidnllg iNMbdico-%-hirnirgical .>ocietv,wliere my colleagues aiid other nmeiibers of the society hald thle opportunity of seeing-
Transcatheter closure of ventricular septal defects.
Authors: J E Lock, P C Block, R G McKay, D S Baim, J F Keane
Journal: Circulation (1988)

Between January and October, 1987, we attempted percutaneous transcatheter closure of seven ventricular septal defects (VSD) in six patients; none of the patients was a candidate for operative management. Patients' ages ranged from 8 months to 82 years (6.0-70 kg); diagnoses included postinfarction VSD (n = 4), congenital VSD (n = 1), and postoperative congenital VSD (n = 2). Indications for VSD closure were shock or respiratory failure (n = 5) or multiple episodes of endocarditis (n = 1). Closure was attempted with a Rashkind double umbrella: VSDs were crossed via the left ventricle and a guide wire was advanced to the right heart, snared with a venous catheter, and used to direct a long sheath (and ultimately the double umbrella) across the VSD. We crossed the VSD in all seven attempts, and a 17-mm double umbrella was successfully placed in each VSD. In the first (postinfarction) patient with the largest (12 mm) VSD, the umbrella embolized after 20 seconds to the pulmonary artery (without reducing flow). The other six umbrellas remained in position, either diminishing or abolishing the left-to-right shunts. Postinfarction patients had increasing VSD shunting over the next several days and died; at postmortem, the umbrellas remained well positioned in the septum, with other VSDs present. All three congenital VSDs had absent or diminished shunts after umbrella closure. These preliminary data indicate that transcatheter VSD closure is feasible in selected cases.
Antisense Proline-Arginine RAN Dipeptides Linked to C9ORF72-ALS/FTD Form Toxic Nuclear Aggregates that Initiate In Vitro and In Vivo Neuronal Death
Authors: Xinmei Wen, Wenzhi Tan, Thomas Westergard, Karthik Krishnamurthy, Shashirekha S. Markandaiah, Yingxiao Shi, Shaoyu Lin, Neil A. Shneider, John Monaghan, Udai B. Pandey, Piera Pasinelli, Justin K. Ichida, Davide Trotti
Journal: Neuron (2014)
Does yttrium radiosynovectomy increase the risk of cancer in patients with rheumatoid arthritis?
Authors: J Vuorela
Journal: Annals of the Rheumatic Diseases (2003)

<b>Objective:</b> To study the long term risk of cancer in patients with rheumatoid arthritis (RA) who have been treated with yttrium. <b>Methods:</b> The medical record numbers of 1228 patients with RA who were admitted to hospital in 1979–85 were identified in the database of Jyväskylä Central Hospital. Radiosynovectomy of the knee joint was performed in a total of 143 patients using yttrium-90 silicate during the years 1970–85, while 1075 did not receive yttrium radiosynovectomy; 10 received yttrium treatment later than 1985 and were excluded from the analysis. The Finnish Cancer Registry database was used to examine whether the subjects had cancer during the follow up from 1979 until the end of 1999. <b>Results:</b> Nine cases of cancer were found among the patients who had received yttrium, whereas the expected number based on the incidence among the population in the region was 14.9. The standardised incidence ratio of cancer was 0.6 (95% confidence interval (CI) 0.3 to 1.1) for the patients who received yttrium, and 1.1 (95% CI 0.9 to 1.3) for the patients who did not receive yttrium. <b>Conclusions:</b> Yttrium treatment did not increase the risk of cancer.
Blastic variant of mantle cell lymphoma: a rare but highly aggressive subtype
Authors: M Bernard, R Gressin, F Lefrère, B Drénou, B Branger, S Caulet-Maugendre, P Tass, N Brousse, F Valensi, N Milpied, L Voilat, A Sadoun, C Ghandour, M Hunault, R Leloup, L Mannone, O Hermine, T Lamy
Journal: Leukemia (2001)
Nasal Carriage in Staphylococcal Skin Infections
Authors: L. G. Tulloch
Journal: BMJ (1954)

(a) Constitutional.-In some individuals favourable condi tions are provided for the growth of staphylococci by virtue, for example, of a hormonal imbalance (especially androgen excess) or a metabolic imbalance (with particular reference to the sugar and water content of the skin). One cannot hope to alter these factors permanently. (b) Immunity.-Active immunization against Staphylo coccus pyogenes is, on the whole, disappointing. Favour able results have, however, been reported with vaccines and with toxoid, especially with the latter (Barber and Forman, 1933; Dolman, 1935; Whitby, 1936; Bocage, Mercier and Pillet, 1947; and others). There is much need for research in this field, and there are reasons for hoping for improve ments in the immunological attack, but detailed discussion of this is beyond the scope of this article. (c) Nasal Carriage.-There is abundant evidence to sug gest that staphylococci flourishing in the anterior nares pro vide the source of infection, and of reinfection after local treatment, in most staphylococcal skin diseases. The anterior nares have been demonstrated to harbour staphylo cocci in greater profusion than any other part of the body and in a very high percentage of the population. Nasal carriage of staphylococci was first demonstrated by Danbolt (1931), and since then many others have carried out investi gations to determine the incidence in the general population. Miles, Williams, and Clayton-Cooper (1944), in a sample of a working-class population, obtained a mean carrier rate of 47.4% ; and Williams (1946), taking a series of eight weekly swabs from each of a number of individuals, ob tained an average carrier rate of 63 0 for any one week, and a total carrier rate over the eight weeks as high as 89%,.
The Life Science: Current Ideas of Biology
Authors: Hugh H. Hussey
Journal: JAMA (1977)

According to the jacket, Sir Peter and Lady Medawar "present in layman's terms a new map of the ideas and concepts that underlie biological thinking today." This usage of the word<i>layman</i>seriously underestimates the scope of the book's audience. Furthermore, each noun in the title is unusually meaningful. This is a book about life and science, and<i>biology</i>must be interpreted broadly to fit with<i>life</i>and<i>science</i>. Throughout the work, the Medawars evince their mastery of philosophic as well as scientific concepts.<i>The Life Science</i>, entirely captivating, is not a book for spot reading, but premedical students, medical students, and practicing physicians will find special delight in many individual chapters. The chapters that relate broadly to evolution cover with extraordinary clarity and completeness many of life's mysteries only recently solved. Especially interesting are its discussions of inheritance, nucleic acids, genetic code, and evolution by natural selection. The brief
RESTRICTION OF GENE EXPRESSION IN B LYMPHOCYTES AND THEIR PROGENY
Authors: Patricia P. Jones, Susan W. Craig, John J. Cebra, Leonard A. Herzenberg
Journal: The Journal of Experimental Medicine (1974)

To determine whether or not B lymphocytes are committed to the synthesis of a single immunoglobulin heavy chain isotype during their differentiation into plasma cells, rabbit lymph node and Peyer's patch cells were separated into populations with and without membrane IgM, using a fluorescence-activated cell sorter (FACS). The potential of the micro-bearing (micro+) and non-micro-bearing (micro-) cells to give rise to plasma cells both in vivo after transfer into irradiated recipients and in vitro in the presence of pokeweed mitogen was assessed by immunofluorescence techniques, and the relative proportions of the cytoplasmic Ig-stained cells (CSC) synthesizing each class of heavy chains were determined. Most of the CSC arising in vitro from micro-bearing lymph node and Peyer's patch cells contained IgM; all IgM CSC appeared to be derived from micro+ cells. Peyer's patch lymphocytes, however, did not generate IgM CSC after cell transfer and thus may be functionally different from lymph node micro+ cells. It was found also that nearly all of the many IgA CSC generated by Peyer's patch lymphocytes either in culture or after transfer were derived from micro- cells. Further fractionation of these micro- cells with the FACS after they had been membrane stained with anti-b locus allotype reagents revealed that the precursors of IgA CSC belong to a minor population of cells which do have b locus light chain determinants on their membranes, although they do not have detectable micro-chains. These cells are not found in lymph nodes. Although the majority of Peyer's patch and lymph node cells were found to be precommitted to the synthesis of a single heavy chain isotype, a small proportion of cells may not be similarly restricted. Some of the CSC with membrane IgM were found to contain cytoplasmic IgA or IgG. In addition, micro+ populations did give rise to low numbers of IgA and IgG CSC. The implications of these results, obtained under experimental conditions, on the normal differentiation of B lymphocytes in situ are discussed.
Flexural pigmentation with multiple lentigines: a new primary pigmentary disorder?
Authors: J.C.C. Ho, Y.C. Chan, Y.C. Giam, B.H. Ong, S.P.W. Kumarasinghe
Journal: British Journal of Dermatology (2005)

Journal Article Flexural pigmentation with multiple lentigines: a new primary pigmentary disorder? Get access J.C.C. Ho, J.C.C. Ho National Skin Centre, 1 Mandalay Road, Singapore 308205 E‐mail: jeanho@nsc.gov.sg Search for other works by this author on: Oxford Academic Google Scholar Y.C. Chan, Y.C. Chan National Skin Centre, 1 Mandalay Road, Singapore 308205 E‐mail: jeanho@nsc.gov.sg Search for other works by this author on: Oxford Academic Google Scholar Y.C. Giam, Y.C. Giam National Skin Centre, 1 Mandalay Road, Singapore 308205 E‐mail: jeanho@nsc.gov.sg Search for other works by this author on: Oxford Academic Google Scholar B.H. Ong, B.H. Ong National Skin Centre, 1 Mandalay Road, Singapore 308205 E‐mail: jeanho@nsc.gov.sg Search for other works by this author on: Oxford Academic Google Scholar S.P.W. Kumarasinghe S.P.W. Kumarasinghe National Skin Centre, 1 Mandalay Road, Singapore 308205 E‐mail: jeanho@nsc.gov.sg Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 154, Issue 2, 1 February 2006, Pages 382–384, https://doi.org/10.1111/j.1365-2133.2005.07054.x Published: 01 February 2006
Evidence of a role for GTP in the potentiation of Ca(2+)-induced insulin secretion by glucose in intact rat islets.
Authors: M Meredith, M E Rabaglia, S A Metz
Journal: Journal of Clinical Investigation (1995)

Glucose initiates insulin secretion by closing K(+)-ATP channels, leading to Ca2+ influx (E1); it also potentiates Ca(2+)-induced secretion (E2) when the K(+)-ATP channel is kept open using diazoxide and depolarizing concentrations of K+ are provided. To examine the roles of purine nucleotides in E2, we compared the effects of glucose to those of the mitochondrial fuel monomethylsuccinate. Either agonist could induce E2 accompanied by significant increases in ATP, ATP/ADP ratio, and GTP/GDP ratio; GTP increased significantly only with glucose. Mycophenolic acid (MPA), an inhibitor of cytosolic GTP synthesis, markedly inhibited glucose-induced E2 (either in perifusions or in static incubations) and decreased GTP and the GTP/GDP ratio, but did not alter the ATP/ADP ratio. Provision of guanine (but not adenine) reversed these changes pari passu. In contrast, MPA had no effect on succinate-induced E2, despite generally similar changes in nucleotides. A similar lack of effect of MPA on E2 was seen with a second mitochondrial fuel, alpha-ketoisocaproic acid (KIC). However, in the absence of diazoxide and K+, MPA blunted the secretory effects of either glucose, succinate, or KIC. These studies suggest that GTP plays a role in both glucose and succinate or KIC-induced insulin secretion at a step dependent on mitochondrial metabolism and the K(+)-ATP channel. In addition to mitochondrial effects, glucose appears to have extramitochondrial effects important to its potentiation of Ca(2+)-induced insulin secretion that are also dependent on GTP.