Hypercalcemia in Patients with Malignant Lymphoma
Authors: ARNOLD M. MOSES
Journal: Annals of Internal Medicine (1963)

Article1 October 1963Hypercalcemia in Patients with Malignant LymphomaARNOLD M. MOSES, M.D., HERTA SPENCER, M.D.ARNOLD M. MOSES, M.D.Search for more papers by this author, HERTA SPENCER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-59-4-531 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHypercalcemia is a serious complication of primary or secondary neoplastic bone disease. Most commonly, hypercalcemia occurs in neoplasms of the breast, lung, kidney (1), and multiple myeloma (2). Several cases of hypercalcemia in patients with lymphomatous disease have been reported (1, 3-5). However, this metabolic aberration in patients with malignant lymphoma has not received the emphasis in the literature that it might merit in view of its incidence.In this communication, a series of 29 patients with malignant lymphoma and tumorous bone involvement, hypercalcemia, or both, are reported. Changes in serum calcium, phosphorus, and alkaline phosphatase levels, and in roentgenographic...References1. MYERS WP: Hypercalcemia in neoplastic disease. Arch. Surg. 80: 308, 1960. CrossrefMedlineGoogle Scholar2. GUTMANTYSONGUTMAN ABTLEB: Serum calcium, inorganic phosphorus, and phosphatase activity: in hyperparathyroidism, Paget's disease, multiple myeloma, and neoplastic disease of the bones. Arch. Intern. Med. (Chicago) 57: 379, 1936. CrossrefGoogle Scholar3. HERRMANNKIRSTENKRAKAUER JBEJS: Hypercalcemic syndrome associated with androgenic and estrogenic therapy. J. Clin. Endocr. 9: 1, 1949. CrossrefGoogle Scholar4. PLIMPTONGELLHORN CHA: Hypercalcemia in malignant disease without evidence of bone destruction. Amer. J. Med. 21: 750, 1956. CrossrefMedlineGoogle Scholar5. KABAKOWMINESKING BMFFH: Hypercalcemia in Hodgkin's disease. New Eng. J. Med. 256: 59, 1957. CrossrefMedlineGoogle Scholar6. SHOHLPEDLEY ATEG: A rapid and accurate method for calcium in urine. J. Biol. Chem. 50: 537, 1922. CrossrefGoogle Scholar7. JAFFE HL: Skeletal manifestations of leukemia and malignant lymphoma. Bull. Hosp. Joint Dis. 13: 217, 1952. MedlineGoogle Scholar8. SPENCERVANKINSCOTTLEWINLASZLO HVID: Removal of calcium in man by ethylenediamine tetra-acetic acid. A metabolic study. J. Clin. Invest. 31: 1023, 1952. CrossrefMedlineGoogle Scholar9. HOLLANDDANIELSONSAHAGIAN-EDWARDS JFEA: Use of ethylene diamine tetra acetic acid in hypercalcemic patients. Proc. Soc. Exp. Biol. Med. 84: 359, 1953. CrossrefMedlineGoogle Scholar10. SPENCERGREENBERGBERGERPERRONELASZLO HJEMD: Studies on the effect of ethylene-diamine-tetra-acetic acid in hypercalcemia. J. Lab. Clin. Med. 47: 29, 1956. MedlineGoogle Scholar11. LASZLOSCHULMANBELLINGOTTESMANSCHILLING DCAJEDA: Mineral and protein metabolism in osteolytic metastases. JAMA 148: 1027, 1952. CrossrefMedlineGoogle Scholar12. RITTERSPENCERSAMACHSON SHJ: The Sulkowitch test and quantitative urinary calcium excretion. J. Lab. Clin. Med. 56: 314, 1960. MedlineGoogle Scholar13. FALCONERLEONARD EHME: Skeletal lesions in Hodgkin's disease. Ann. Intern. Med. 29: 1115, 1948. LinkGoogle Scholar14. GRIBOFFHERRMANNSMELINMOSS SIJBAJ: Hypercalcemia secondary to bone metastases from carcinoma of the breast. I. Relationship between serum calcium and alkaline phosphatase values. J. Clin. Endocr. 14: 378, 1954. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Syracuse, New YorkFrom Veterans Administration Hospital, Syracuse, New York, and Department of Medicine, State University of New York, Upstate Medical Center, and Metabolic Section, Veterans Administration Hospital, Hines, Illinois.This study was supported in part by grant C-6114 from the National Cancer Institute, National Institutes of Health, Bethesda, Maryland.Requests for reprints should be addressed to Arnold M. Moses, M.D., Veterans Administration Hospital, Irving Avenue and University Place Syracuse 10, New York. 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LEE, M.D.Hypercalcämie bei LymphogranulomatoseBone Manifestations of Hematologic Disorders 1 October 1963Volume 59, Issue 4Page: 531-536KeywordsBoneCalciumHospital medicineHypercalcemiaLungsLymphomaMultiple myelomaPhosphatasesPhosphorusRenal cancer Issue Published: 1 October 1963 PDF DownloadLoading ...