tbuckley/cabot-search huggingface dataset:
Upregulation of DLX5 Promotes Ovarian Cancer Cell Proliferation by Enhancing IRS-2-AKT Signaling
Authors: Yinfei Tan, Mitchell Cheung, Jianming Pei, Craig W. Menges, Andrew K. Godwin, Joseph R. Testa
Journal: Cancer Research (2010)

Abstract The distal-less homeobox gene (dlx) 5 encodes a transcription factor that controls jaw formation and appendage differentiation during embryonic development. We had previously found that Dlx5 is overexpressed in an Akt2 transgenic model of T-cell lymphoma. To investigate if DLX5 is involved in human cancer, we screened its expression in the NCI 60 cancer cell line panel. DLX5 was frequently upregulated in cell lines derived from several tumor types, including ovarian cancer. We next validated its upregulation in primary ovarian cancer specimens. Stable knockdown of DLX5 by lentivirus-mediated transduction of short hairpin RNA (shRNA) resulted in reduced proliferation of ovarian cancer cells due to inhibition of cell cycle progression in connection with the downregulation of cyclins A, B1, D1, D2, and E, and decreased phosphorylation of AKT. Cell proliferation resumed following introduction of a DLX5 cDNA harboring wobbled mutations at the shRNA-targeting sites. Cell proliferation was also rescued by transduction of a constitutively active form of AKT. Intriguingly, downregulation of IRS-2 and MET contributed to the suppression of AKT signaling. Moreover, DLX5 was found to directly bind to the IRS-2 promoter and augmented its transcription. Knockdown of DLX5 in xenografts of human ovarian cancer cells resulted in markedly diminished tumor size. In addition, DLX5 was found to cooperate with HRAS in the transformation of human ovarian surface epithelial cells. Together, these data suggest that DLX5 plays a significant role in the pathogenesis of some ovarian cancers. Cancer Res; 70(22); 9197–206. ©2010 AACR.
Bragg Peak Proton Beam Irradiation of the Pituitary Gland for Proliferative Diabetic Retinopathy
Authors: CHOODAPPA S. MUNICHOODAPPA
Journal: Annals of Internal Medicine (1971)

Bragg peak proton beam irradiation of the pituitary gland for proliferative diabetic retinopathy was carried out in 56 patients. Most of them had been considered unsuitable for surgical hypophysectomy because of significant cardiovascular or renal disease, or both. Fifty-five were followed for an average of 4 years. Twenty-six attained moderate to maximal reduction in pituitary function; in 24 patients this occurred after a mean lapse of 7.2 months. Improvement or stabilization in vision was noted in 28 of 55 patients overall (51%), and in 10 of 13 (77%) after maximal pituitary suppression. Forty-six percent showed improvement in angiopathy. A positive correlation was noted between the degree of pituitary suppression and improvement or stabilization in vision and angiopathy. Two patients developed oculomotor nerve palsy. Recovery was complete in one and partial in the other. Bragg peak proton beam irradiation of the pituitary gland for proliferative diabetic retinopathy carries little morbidity and no mortality. It is a useful and safe tool, particularly in patients with compromised cardiovascular and renal status.
Borrelia afzelii evidenced by polymerase chain reaction in a biopsy of nipple lymphocytoma
Authors: P-D. Ghislain, S. Woestyn, D. Tennstedt, J-M. Lachapelle, G. Bigaignon, M. Delmee
Journal: British Journal of Dermatology (2003)

Journal Article Borrelia afzelii evidenced by polymerase chain reaction in a biopsy of nipple lymphocytoma Get access P‐D. Ghislain, P‐D. Ghislain Service de Dermatologie and Search for other works by this author on: Oxford Academic Google Scholar S. Woestyn, S. Woestyn Laboratoire de Microbiologie Cliniques Universitaires Saint‐Luc, Avenue Hippocrate, B‐1200 Brussels, Belgium E‐mail: PierreDominique.Ghislain@advalvas.be Search for other works by this author on: Oxford Academic Google Scholar D. Tennstedt, D. Tennstedt Service de Dermatologie and Search for other works by this author on: Oxford Academic Google Scholar J‐M. Lachapelle, J‐M. Lachapelle Service de Dermatologie and Search for other works by this author on: Oxford Academic Google Scholar G. Bigaignon, G. Bigaignon Laboratoire de Microbiologie Cliniques Universitaires Saint‐Luc, Avenue Hippocrate, B‐1200 Brussels, Belgium E‐mail: PierreDominique.Ghislain@advalvas.be Search for other works by this author on: Oxford Academic Google Scholar M. Delmée M. Delmée Laboratoire de Microbiologie Cliniques Universitaires Saint‐Luc, Avenue Hippocrate, B‐1200 Brussels, Belgium E‐mail: PierreDominique.Ghislain@advalvas.be Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 148, Issue 2, 1 February 2003, Pages 377–379, https://doi.org/10.1046/j.1365-2133.2003.05097_12.x Published: 01 February 2003
OBSTRUCTION OF BOWELS FROM GALLSTONE.
Authors: R. H. POWELL
Journal: JAMA (1905)

Obstruction of the bowels from gallstone is of infrequent occurrence, being variously estimated from 8 to 15 per cent. of all intestinal obstructions. I may be pardoned, therefore, for reporting a case occurring in the practice of Dr. Ithamar Davisson, of Flemington, a village ten miles from this city, and in which I was called in consultation the night previous to the day of operation. <h3>History.</h3> —A woman, aged 56, multipara, rather corpulent, had had stercoraceous vomiting for two days; there had been no movement of the bowels for five days, with severe pain in the epigastric region. Patient gave a history of having had attacks of gallstone colic about eight years previously, but had had no recurrence until the beginning of present illness. When I saw the woman she had a temperature of 100.4 degrees; the pulse rate was 120. Early the next day she was brought to the
Methadone Overdose Deaths Rise With Increased Prescribing for Pain
Authors: Bridget M. Kuehn
Journal: JAMA (2012)

METHADONE WAS INVOLVED IN more than 30% of overdose deaths linked to the use of prescription painkillers in 2009, despite the drug making up only about 2% of painkiller prescriptions that year, according to a report from the US Centers for Disease Control and Prevention (CDC). Methadone, which has been used successfully for more than 40 years as a treatment for heroin addiction, has been widely prescribed over the past decade for the treatment of pain. In 2009, more than 4 million prescriptions for methadone were written for pain patients, according to the CDC. As the number of methadone prescriptions for pain has increased, methadone overdose deaths have increased, noted CDC director Thomas R. Frieden, MD, MPH, in a press briefing. There are 5000 such overdose fatalities each year, more than the number of heroin and cocaine overdoses combined, he said. “All the data suggest the increase is related to the use of methadone to treat pain,” said Frieden.
Consensus on Antenatal Steroids
Authors: Joan Stephenson
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CESAREAN SECTION FOR PLACENTA PREVIA.
Authors: JOHN B. DEAVER
Journal: JAMA (1904)

Resort to cesarean section as a means of delivery for a patient with placenta previa is still a sufficiently rare procedure to make the history and result of every case a matter of general interest.For conservative cesarean section for other conditions the mortality for the mother is about 10 per cent., and that for the fetus from 5 to 10 per cent.The mortality for the mother with placenta previa, treated by means other than cesarean section, is about 11 per cent., while Operators.
Modulation of sodium current by lactate in guinea pig ventricular myocytes
Authors: H. Tanaka, Y. Habuchi, L.-L. Lu, T. Furukawa, J. Morikawa, M. Yoshimura
Journal: Cardiovascular Research (1994)

The aim was to elucidate whether or not lactate modifies the fast sodium current (INa) in cardiac cells.A tight seal whole cell clamp technique was used to record the action potentials and INa in single ventricular cells from the guinea pig heart.In voltage clamp experiments, superfusion with 20 mM lactate shifted both the normalised conductance (gNa)-voltage relationship and the channel availability curve toward hyperpolarisation by approximately 4 mV, but did not affect the maximum conductance (gNa,max). In the test solution containing only CaCl2 as the main divalent component, 20 mM lactate reduced the ionised calcium concentration from 1.02 to 0.84 mM. When the calcium concentration was kept constant by the addition of CaCl2 into the lactate containing solution the lactate effect was nullified. However, a change in the calcium concentration from 1.0 to 0.84 mM without lactate induced a 4 mV negative shift of the channel availability curve. Current clamp experiments in Tyrode solution showed that 20 mM lactate shifted the threshold for the action potential upstroke by 2.5-3 mV, in accordance with the voltage clamp experiments.Lactate modifies INa of ventricular myocytes by shifting its kinetics toward hyperpolarisation. This shift seems to be caused exclusively by a decrease in the ionised divalent cation concentrations and a resultant change in the negative surface charge of the sarcolemma.
Growth Reduction vs Budget Cuts for Medicare: What's in a Name?
Authors: Matthew K. Wynia
Journal: JAMA (1996)

To the Editor.  —Dr Wright 1 defends proposed Republican changes to Medicare as necessary and good because, he claims, Medicare spending must be reduced to save the Medicare Trust Fund and, moreover, because a reduction in expected spending for Medicare is not actually a budget cut. These assertions are startling.  The news that current Republican proposals are urgently needed to save the Medicare Trust Fund is surprising for 2 reasons. First, the trust fund covers Medicare Part A only, while more than half of Republicans' proposed cuts come from Part B. Second, for years the trustees of Medicare have issued little-noted reports explaining when in the future the trust fund could run out of money; now, suddenly, Republicans propose urgent reductions that, incidentally, are at least 3 times larger than necessary to solidify the fund.  Wright's distaste for the word cut in the context of Medicare is also intriguing. Previously
Prognostic Factors in Anorexia nervosa
Authors: Klaus Engel
Journal: Psychotherapy and Psychosomatics (1988)

Preclinical inpatient therapy and postclinical prognostic factors concerning 113 cases were empirically scrutinized and hierarchically classified in accordance with their importance, especially in light of the relative weight of somatic, psychologic, or social variables. The criterion is the state of health at the time of follow-up, after 6.4 years. The results thus obtained are the basis of therapy recommendations.
THE STANDARDIZATION OF LONGEVITY AGAINST DOSE IN EXPERIMENTAL TUBERCULOSIS BY INTRACEREBRAL INOCULATION
Authors: Kenneth C. Smithburn
Journal: The Journal of Experimental Medicine (1936)

Intracerebral inoculation of tuberde bacilli into normal guinea pigs induces acute meningoencephalitis with minor metastatic lesions. The disease is fatal in a relatively short time and is characterized by a rather typical succession of symptoms and a fairly characteristic temperature curve. The disease is produced by very small numbers of bacilli; and under standard conditions, survival time is so uniform as to make possible quantitative or titration experiments. Certain possible applications of the method are discussed.
&lt;emph type="ital"&gt;Spring Rain, New York&lt;/emph&gt;
Authors: Thomas B. Cole
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The role of the spleen in experimental pneumococcal bacteremia.
Authors: E J Brown, S W Hosea, M M Frank
Journal: Journal of Clinical Investigation (1981)

The importance of the spleen in host defense against pneumococcal bacteremia has been suggested by a number of experimental models as well as the occurrence of the syndrome of overwhelming pneumococcal sepsis in asplenic individuals. We studied the mechanism of splenic protection against pneumococcal bacteremia using a guinea pig model. Rates of removal of pneumococci from the blood stream in normal and splenectomized guinea pigs were compared with the extent of hepatic and splenic sequestration of radiolabeled organisms for three different types of pneumococci. A relationship was found between the virulence of a pneumococcus for normal guinea pigs, the extent to which it is cleared by the spleen, and the magnitude of the defect in blood stream sterilization induced by splenectomy. The spleen plays an increasingly important role in the clearance of progressively more virulent organisms, for which hepatic clearance cannot compensate. Thus, the division between hepatic and splenic clearance of bacteremia is a key determinant of the outcome of experimental pneumococcal infection.
Meat Intake and Non-Hodgkin Lymphoma-Reply
Authors: James R. Cerhan
Journal: JAMA (1996)

<h3>In Reply.</h3> —Dr Kritchevsky raises the possibility that our results might be influenced by transient dietary changes due to potential metabolic effects of subclinical NHL, reversing the <h3>Requirements for Letters</h3> Letters will be published at the discretion of the editors as space permits and are subject to editing and abridgment. Letters will be considered if they are typewritten double-spaced and do not exceed 500 words of text and 5 references. Please include a word count. Letters discussing a recent<i>JAMA</i>article should be received within 4 weeks of the article's publication. Letters must not duplicate other material published or submitted for publication. A signed statement for authorship criteria and responsibility, financial disclosure, copyright transfer, and acknowledgment is essential for publication. Letters not meeting these specifications are generally not considered. Letters will not be returned unless specifically requested. Also see<i>JAMA</i>Instructions for Authors (July 3,1996). Letters may be submitted by surface mail:
Benign Intrathoracic Lesions Mimicking Recurrent Cancer
Authors: Edward A. Sickles
Journal: JAMA (1973)

Three of 15 cancer patients with suspected intrathoracic tumor recurrence were found on biopsy to have only benign mass lesions. These cases emphasize that medical work-up, short of biopsy, is often inadequate in the evaluation of intrathoracic masses, and that a history of neoplasm is not sufficient cause to abandon tissue diagnosis before proceeding to therapy.
Dutch move to end consultants' freedom
Authors: T. Sheldon
Journal: BMJ (1997)

After five years of negotiations the first step has been taken to integrate Dutch consultants into the hospital management structure and limit their freedom to act as self employed entrepreneurs.

With the exception of consultants in university hospitals, who are paid a salary, most of the 13000 hospital consultants, or medical specialists, in the Netherlands charge their patients fees for services that are based on national tariffs. The patient receives a separate bill from the hospital.

Under the new legislation, which health minister Professor Els Borst-Eilers laid before parliament …
Effect of kapalbhati on selected body composition variables
Authors: Ajay Singh Ruhal, Rakesh Bhandari, Ranjan Chakravarti
Journal: British Journal of Sports Medicine (2010)

The purpose of the study 30 male students of BPE first year of LNIPE (Deemed University), Gwalior were randomly selected as subjects for this study. Subjects were divided into two groups that is, one experimental group and one control group. The quantitative measurements of each subject were taken with the help of standard equipment, before and after the treatment period of 12 weeks. The selected body composition variables were body fat (%), lean body mass (kg), body water content (%) and basal metabolic rate (KCl) were administered in the Yoga Laboratory of the Institute. Paired ‘t’ test was applied to determine the effect of kapalbhati on selected body composition variables. The paired ‘t’ test revealed that practice of kapalbhati pranayama had significant effect on body fat % (t = 5.47, against required value of 1.761), lean body mass (t = 9.65, against required value of 1.761), body water content (t = 17.24, against required value of 1.761) and basal metabolic rate (t = 9.410, against required value of 1.761) which showed significant effect of practice of kapalbhati pranayama. On the basis of results following conclusions were drawn: (1) significant effect was found on body fat % and no change was found in control group. (2) Significant effect was found on lean body mass and no change was found in control group. (3) Significant effect was found on body water content and no change was found in control group. (4) Significant effect was found on basal metabolic rate and no change was found in control group.
Insensitivity of Guaiac Slide Tests for Detection of Blood in Gastric Juice
Authors: EDWARD A. LAYNE
Journal: Annals of Internal Medicine (1981)

Two guaiac slide tests (Hemoccult and Fe-Cult) were evaluated for their ability to detect blood in gastric juice and other fluid mixtures relevant to clinical testing in upper gastrointestinal hemorrhage. Blood was added to these fluid mixtures in various amounts sufficient to yield concentrations from 20 microL blood/dL to 4000 microL/dL. With these agents we frequently could not detect blood in unbuffered gastric juice at concentrations as great as 4000 microL/dL. Buffering of gastric juice to pH 4 with either of two antacids only slightly restored sensitivity for blood detection. In contrast, blood in gastric juice obtained from subjects previously given intravenous cimetidine tested positive at concentrations as low as 50 microL/dL. The ability of both test agents to detect blood in gastric juice was considerably enhanced by neutralizing gastric juice with 0.1 N NaOH.
Laetrile on Trial
Authors: Thomas H. Jukes
Journal: JAMA (1979)

ON SEPT 27, 1978, Arthur Upton, MD, director of the National Cancer Institute (NCI), announced that the NCI would conduct a clinical trial of laetrile in 150 to 300 patients with terminal cancer. This COMMENTARY reviews some of the background and implications of this decision as I see them. <h3>The NCI Laetrile Review1</h3> This was a review of cases thought to have shown objective benefit from use of laetrile. The case reports were obtained by mailing requests to 385,000 physicians and 70,000 other health proponents and by direct contact with pro-laetrile groups. Only 93 cancer cases were submitted for evaluation, and 26 of these were rejected because of incomplete data. A panel (names listed in review) judged six of the remaining 67 patients to have responded (two completely and four partially). One of 24 "no treatment" control patients showed a partial response. The authors warn that "submission of incorrect
Aprotinin‐associated hemolytic thrombotic microangiopathy in a patient with acute myelogenous leukemia (AML) and systemic coagulopathy
Authors: Florian Langer, Oliver Steinmetz, Guy Marx, Ali Amirkhosravi, Barbara Eifrig, Carsten Bokemeyer, Tim Brümmendorf
Journal: American Journal of Hematology (2007)
Epithelioid Hemangioendothelioma of the Liver With F-18 FDG PET Imaging
Authors: Ba D. Nguyen
Journal: Clinical Nuclear Medicine (2004)

Epithelioid hemangioendothelioma is an uncommon vascular tumor of the liver with a low to intermediate degree of malignancy. Radiologic cross-sectional imaging patterns have been reported along with scintigraphic features. The author presents the PET imaging findings of this rare hepatic neoplasm with CT and MR correlation. Epidemiology, histopathology, imaging characteristics, and therapeutic outcomes of hepatic epithelioid hemangioendothelioma are briefly reviewed.
Measurement of isovolumic relaxation: comparison of echocardiographic mitral valve opening and Doppler mitral valve flow
Authors: L M SHAPIRO, B C THWAITES
Journal: Cardiovascular Research (1987)

The relation between mitral valve opening and transmitral blood flow was investigated by M-mode echocardiography and Doppler ultrasound in 50 normal subjects to allow the measurement of the timing of the end of isovolumic relaxation. Standard parasternal M-mode echocardiograms of the mitral valve to show the onset of cusp separation were recorded with a simultaneous electrocardiogram and phonocardiogram. Pulse wave Doppler ultrasound using both amplitude and spectral analysis was recorded with a transducer at the apex, and the initial diastolic blood flow towards the transducer was taken as the onset of flow. For each subject five cardiac cycles of similar length were measured using the three methods. Isovolumic relaxation could be measured with a high degree of reliability (retest reliability coefficient >0.94). The echocardiographic measurement of isovolumic relaxation ranged from 52 to 82 ms (mean(SD) 67(9) ms). Isovolumic relaxation measured by Doppler was 52-83 ms (mean(SD) 67(9) ms) using amplitude analysis and 54-89 ms (mean(SD) 72(11) ms) using spectral analysis. There was a strong correlation between the echocardiographic isovolumic relaxation and measurements made using spectral analysis (r=0.93, slope 0.97) and amplitude analysis (r=0.97, slope 0.98). Therefore in normal subjects the end of isovolumic relaxation can be reliably measured by echocardiographic and Doppler methods, and whereas the amplitude signal is coincidental with that measured by echocardiogrphy that measured by spectral analysis is delayed by approximately 5 ms.