tbuckley/cabot-search huggingface dataset:
A Clinical Study of Ulcerative Colitis
Authors: George L. Engel
Journal: JAMA (1963)

<h3>To the Editor:</h3> —The report by Fullerton, Kollar, and Caldwell (<b>181</b>:463 [Aug 11] 1962), of patients with ulcerative colitis, constitutes a valuable addition to our growing information on some of the psychological aspects of this disorder. I was particularly gratified to find a considerable measure of validation of many of the psychological data we reported some years ago, based on clinical observation (Engel, G.L.: Studies of Ulcerative Colitis: III. Nature of Psychologic Processes,<i>Amer J Med</i><b>19</b>:231 [Aug] 1955). However, as reported, the study by Fullerton et al has certain limitations which I feel should be made explicit, since they are not sufficiently emphasized in their paper. For one thing, this report would more properly be identified as a study of men with ulcerative colitis rather than a study of ulcerative colitis. The authors note, but do not sufficently emphasize, that 45 out of the 47 patients were
1133-158 Evaluation of myocardial ischemica by magnetic resonance myocardial stress perfusion in renal transplant candidates: Comparison with SPECT and coronary angiography
Authors: Joalbo M Andrade, Carlos E Rochitte, Luiz H Gowdak, Flávio J Paula, Maria C.P Giorgi, JoséR Parga, Luiz F Ávila, JoséA.F Ramires, JoséJ.G Lima
Journal: Journal of the American College of Cardiology (2004)
Early diagnosis of breast cancer
Authors: R. H Armour
Journal: BMJ (1976)

wound primarily in perforated appendicitis and possibly in purulent and gangrenous cases too.(When else would one sew up tissues steeped in faecal pus ?)An acceptable alterna- tive is delayed primary suture, with a wet gauze pack to the intermuscular layers for four days.I am grateful to my colleagues who kindly allowed me to examine their patients' records, so illustrating the need for another look at appendicectomy.
Novel mutation in ferroportin 1 gene is associated with autosomal dominant iron overload
Authors: Anne-Marie Jouanolle, Véronique Douabin-Gicquel, Chantal Halimi, Olivier Loréal, Patricia Fergelot, Thierry Delacour, Anne-Sophie de Lajarte-Thirouard, Bruno Turlin, Jean-Yves Le Gall, Estelle Cadet, Jacques Rochette, Véronique David, Pierre Brissot
Journal: Journal of Hepatology (2003)
THE CAUSAL RELATION INTRA-ABDOMINAL DISEASES BEAR TO NERVOUS DISTURBANCES RECOGNIZED BY GYNECOLOGISTS, IGNORED BY NEUROLOGISTS.
Authors: HENRY O. MARCY
Journal: JAMA (1900)

Perhaps the most difficult of subjects for the master to teach or the student to master are the reflexes of the nervous system and their influence upon the functions of the various organs. In a certain sense are we not yet students? That all-pervading, ever-acting force that from infancy to old age should hold in stable equilibrium the harmonic rhythm of the individual, for want of a better term we may designate "vital." This life power we know has its definite limitations, although, as one forecasts the future of the individual, he is aware that it must be expressed in the unknown terms of the algebraic formula "x+y" or "x-y." If in health it is so difficult to graduate and measure the possibilities of the individual or determine his daily perturbations within the limit of normal function, how much more abstruse is the problem to detect and to judge aright
Urinary excretion of retinol in patients with multiple myeloma: A preliminary study
Authors: Vladimir Gavrilov, Tikva Yermiahu, Rafael Gorodischer
Journal: American Journal of Hematology (2003)

Abstract Urinary excretion of vitamin A was studied in patients with multiple myeloma (MM). Eight of the 12 patients studied excreted retinol in urine; only one of them had elevated serum creatinine (115–150 μmol/L). There was a highly significant correlation between urinary retinol and serum creatinine ( P &lt; 0.0004). Urinary retinol correlated also with urine protein ( P &lt; 0.0001) and albumin ( P = 0.001), but not with urinary immunoglobulin light chains. Urinary retinol excretion may be an early manifestation of renal dysfunction in MM patients. The effect of urinary retinol excretion on vitamin A homeostasis in MM deserves further study. Am. J. Hematol. 74:202–204, 2003. © 2003 Wiley‐Liss, Inc.
High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis
Authors: Rohit Kohli, Michelle Kirby, Stavra A. Xanthakos, Samir Softic, Ariel E. Feldstein, Vijay Saxena, Peter H. Tang, Lili Miles, Michael V. Miles, William F. Balistreri, Stephen C. Woods, Randy J. Seeley
Journal: Hepatology (2010)

Abstract Diets high in saturated fat and fructose have been implicated in the development of obesity and nonalcoholic steatohepatitis (NASH) in humans. We hypothesized that mice exposed to a similar diet would develop NASH with fibrosis associated with increased hepatic oxidative stress that would be further reflected by increased plasma levels of the respiratory chain component, oxidized coenzyme Q9 (oxCoQ9). Adult male C57Bl/6 mice were randomly assigned to chow, high-fat (HF), or high-fat high-carbohydrate (HFHC) diets for 16 weeks. The chow and HF mice had free access to pure water, whereas the HFHC group received water with 55% fructose and 45% sucrose (wt/vol). The HFHC and HF groups had increased body weight, body fat mass, fasting glucose, and were insulin-resistant compared with chow mice. HF and HFHC consumed similar calories. Hepatic triglyceride content, plasma alanine aminotransferase, and liver weight were significantly increased in HF and HFHC mice compared with chow mice. Plasma cholesterol ( P &lt; 0.001), histological hepatic fibrosis, liver hydroxyproline content ( P = 0.006), collagen 1 messenger RNA ( P = 0.003), CD11b-F4/80+Gr1+ monocytes ( P &lt; 0.0001), transforming growth factor β1 mRNA ( P = 0.04), and α-smooth muscle actin messenger RNA ( P = 0.001) levels were significantly increased in HFHC mice. Hepatic oxidative stress, as indicated by liver superoxide expression ( P = 0.002), 4-hydroxynonenal, and plasma oxCoQ9 ( P &lt; 0.001) levels, was highest in HFHC mice. Conclusion: These findings demonstrate that nongenetically modified mice maintained on an HFHC diet in addition to developing obesity have increased hepatic ROS and a NASH-like phenotype with significant fibrosis. Plasma oxCoQ9 correlated with fibrosis progression. The mechanism of fibrosis may involve fructose inducing increased ROS associated with CD11b+F4/80+Gr1+ hepatic macrophage aggregation, resulting in transforming growth factor β1–signaled collagen deposition and histologically visible hepatic fibrosis.
Corticotropin-Releasing Factor Acts on the Brain to Reduce Gastric Contractility
Authors: Thomas Garrick, Afshin Veiseh, Yvette Taché, Herbert Weiner
Journal: Psychotherapy and Psychosomatics (1987)

Various stressors (cold restraint, electric shock, etc.) applied to rats increase gastric contractility and are associated with gastric erosions. Intracisternal (i.e.) thyrotropin-releasing hormone (TRH) increases contractility, gastric acid secretion and the incidence of erosion formation. Corticotropin-releasing hormone (CRF) is released by stress, and acting centrally produces autonomic and endocrine changes. We have studied the role of i.e. CRF on gastric contractility in anesthetized rats (n = 6). Contractility was measured by extraluminal force transducers sutured to the gastric corpus. Frequency, amplitude of contractions and a motility index were analyzed by computer. Baseline measures, after recovery from surgery were obtained in 24-hour fasted rats. Contractility was stimulated by intravenous carbachol (100 mg/kg/h) or i.e. injection of the TRH analog, RX 77368. Contractility thus induced was inhibited by intravenous atropine (1 mg/kg). CRF (30–1,000 ng i.e.) produced a dose-dependent suppression of RX 77368 (p < 0.05) but had no effect on that induced by intravenous carbachol; saline i.e. had none either. Intravenous CRF was 1/10th as potent in suppressing contractions produced by i.e. RX 77368. Diminution of gastric contractions after i.e. CRF (1 mg) occurred within 5 min of administration, and lasted for at least 60 min. These data show that i.e. CRF injection acts centrally to inhibit gastric contractions stimulated centrally (i.e. by i.e. RX 77368) but not peripherally (i.e. by carbachol), and by inference reduces the risk of erosion formation induced by some stressors.
Agenesis of the Serratus Anterior Muscle: A Cause of Winged Scapula
Authors: Stuart E. Levin
Journal: JAMA (1973)

<h3>To the Editor.—</h3> We recently performed an exploratory thoracotomy on a 64-year-old man with bronchogenic carcinoma of the left upper lobe. Preoperatively, he was noted to have a "winged" scapula on the affected side, an abnormality existing as far back as he could remember. The cause of his deformity became obvious, when in the course of making the operative incision, a total absence of the serratus anterior was discovered. The serratus anterior muscle arises from the outer surfaces of the upper eight or nine ribs and inserts along the medial aspect of the scapula on its costal surface. Its major function is to draw the scapula forward, especially its inferior angle, thereby allowing upward rotation of the scapula, necessary for full arm abduction. It also holds the medial border of the scapula against the thoracic cage. Any paralysis of the muscle results in "winging." The muscle is supplied by the
THE AGGLUTINATION REACTIONS OF THE MORGAN BACILLUS NO. 1
Authors: I. J. Kligler
Journal: The Journal of Experimental Medicine (1919)

The study of the cultural and agglutinating reactions of seventeen strains of Morgan bacilli is reported. The cultures were obtained from different sources. Culturally all the strains were identical. Antigenically they were highly diversified. The sera produced against some strains have marked agglutinating power for other strains, but absorption tests showed that the cross-agglutinations were often due to group agglutinins. While no conclusion can be drawn regarding the pathogenic significance of this bacillus, the wide diversities of antigenic properties raise the question as to the specific relationship of the various cultures met with as well as their relation to a definite class of pathological processes in man.
Myeloperoxidase-Mediated Platelet Release Reaction
Authors: Robert A. Clark, Seymour J. Klebanoff
Journal: Journal of Clinical Investigation (1979)

The ability of the neutrophil myeloperoxidase-hydrogen peroxide-halide system to induce the release of human platelet constituents was examined. Both lytic and nonlytic effects on platelets were assessed by comparison of the simultaneously measured release of a dense-granule marker, [3H]serotonin, and a cytoplasmic marker, [14C]adenine. Incubation of platelets with H2O2 alone (20 μM H2O2 for 10 min) resulted in a small, although significant, release of both serotonin and adenine, suggesting some platelet lysis. Substantial release of these markers was observed only with increased H2O2 concentrations (>0.1 mM) or prolonged incubation (1-2 h).
Gout in black South Africans: a clinical and genetic study.
Authors: B Cassim, G M Mody, V K Deenadayalu, M G Hammond
Journal: Annals of the Rheumatic Diseases (1994)

OBJECTIVE--To define the clinical characteristics of gout and determine if there were any genetic associations with gout in black South Africans. METHODS--The records of 107 patients with gout seen over a five year period were retrospectively analysed. The HLA class I and class II antigens were studied in a prospective survey of 46 patients. RESULTS--The male to female ratio was 6.6:1. The diagnosis of gout was based on identification of monosodium urate crystals from the synovial fluid, synovial tissue or tophaceous material in 62 patients (58%) and on clinical criteria in the remaining 45 patients (42%). The mode of presentation was monoarthritis in 40 patients (37.4%), pauciarthritis in 30 (28%) and polyarthritis in 37 (34.6%). The joints which were most frequently involved were the knee in 91 patients (85%), the first metatarsophalangeal in 80 (74.8%) and the ankle in 66 (61.7%). A secondary cause was identified in 52 patients (48.6%) (diuretic therapy in 48 patients and chronic renal impairment in four); 55 patients (51.4%) had primary gout. The genetic study showed an increased frequency of HLA-B14 in patients with primary gout compared with controls. CONCLUSIONS--Gout is more common in black Africans than previously recognised and frequently presents with involvement of more than one joint. There was an increased frequency of HLA-B14 in patients with primary gout but the clinical significance of this is uncertain.
Chronic Kidney Disease and the Public Health
Authors: Jonathan Himmelfarb
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Use of Tc-99m Sestamibi Infusion for Detection of Hibernating Myocardium A Preliminary Report
Authors: STEFAN D. MIRON, ROBERT FINKELHOR, ROBERT BAHLER, D. BRUCE SODEE, ERROL M. BELLON
Journal: Clinical Nuclear Medicine (1995)

To evaluate whether a prolonged infusion of Tc-99m sestamibi allows for visualization of viable myocardium in areas of hypoperfused myocardium, 25 patients were prospectively studied. Each patient was imaged four times in two consecutive days in the following manner: day 1: 1) Immediately after injection of TI-201 at rest, 2) 1 hour after a bolus injection of Tc-99m sestamibi at rest; and day 2:1) Imaging in the TI-201 window for 24 hour redistribution, 2) Imaging after a 1-hour infusion of Tc-99m sestamibi. The two Tc-99m sestamibi and two TI-201 studies were evaluated for presence of redistribution. This was present both on the TI-201 and Tc-99m sestamibi studies (concordant) in 13 cases, and absent on both the TI-201 and Tc-99m sestamibi studies (concordant) in 9 cases. In two cases redistribution was seen on the TI-201 images only, and in one case it was seen on the Tc-99m sestamibi images only (discordant). Tc-99m sestamibi infusion may provide information about the presence of viable myocardium which is similar to that provided by TI-201 24-hour imaging.
Pomalidomide alone or in combination with low-dose dexamethasone in relapsed and refractory multiple myeloma: a randomized phase 2 study
Authors: Paul G. Richardson, David S. Siegel, Ravi Vij, Craig C. Hofmeister, Rachid Baz, Sundar Jagannath, Christine Chen, Sagar Lonial, Andrzej Jakubowiak, Nizar Bahlis, Kevin Song, Andrew Belch, Noopur Raje, Chaim Shustik, Suzanne Lentzsch, Martha Lacy, Joseph Mikhael, Jeffrey Matous, David Vesole, Min Chen, Mohamed H. Zaki, Christian Jacques, Zhinuan Yu, Kenneth C. Anderson
Journal: Blood (2014)
New rules for expert witnesses
Authors: M. Friston
Journal: BMJ (1999)

Those clinicians who provide reports for use in the civil courts of England and Wales will find their practice changing over the next few months. There are fresh opportunities for those new to medicolegal work to take on stimulating (and well paid) work, but clinicians with established practices may well lose out.

The civil justice system in England and Wales has just undergone an upheaval. The changes began in 1994 when Lord Woolf was appointed to review the rules and procedures of the civil courts in England and Wales. The aims of the review were (principally) to improve access to justice and to reduce the costs of litigation. Lord Woolf was particularly troubled by the escalating cost of expert witnesses and the delay caused by the need to engage experts.1 Although Lord Woolf did not target clinical experts specifically, he complained in his final report that experts had become partisan advocates rather than neutral givers of opinions.2

The Woolf reports have crystallised into a new set of procedural rules …
Variability in the measurement of regional left ventricular wall motion from contrast angiograms.
Authors: F H Sheehan, D K Stewart, H T Dodge, S Mitten, E L Bolson, B G Brown
Journal: Circulation (1983)

Four types of variability affecting quantification of regional wall motion from contrast left ventriculograms (LVgrams) were studied. These included beat-to-beat variability in 24 LVgrams, intraobserver and interobserver variability in 20 LVgrams, and study-to-study variability in serial LVgrams of 21 patients with stable coronary artery disease. Motion was measured at 100 equidistant chords perpendicular to a center line drawn midway between the end-diastolic and end-systolic contours and normalized for heart size. Variability was computed as the absolute difference between observations. Beat-to-beat, intraobserver, and interobserver variability at the 100 chords were similar, averaging 14%, 14%, and 17%, respectively, of the mean motion in 64 patients with normal ventriculograms. Study-to-study variability was significantly higher, averaging 30% of mean normal motion, but was reduced when regional motion was calculated as the mean motion of chords within a region of interest. Variability peaked at the apex. Realignment to correct for cardiac rotation significantly increased variability. Investigators whose methods of wall motion analysis rely on identification of the apex as a landmark should be aware of this source of potential variability and error.
A CASE OF VAQUEZ'S DISEASE: (POLYCYTHAEMIA WITH PLETHORA, AND SPLENOMEGALY)
Authors: H. L. Watson-Wemyss
Journal: BMJ (1913)

rAPRIL 5, 7gr3I Conclusion.Let me enter a plea for raising the standard of this branch of surgery, by making it an operation of precision, and removing somne of the reproach of doubtful value and rinefficiency attached to it.In this connexion I should like to quote the following extracts from Dr. Still's excel- lent book on Common Disorders of Childhood: "I would lay stress upon the importance of complete removal of adenoids and tonsils by whatever method is found to be most practicable."" I wvill venture to insist that the operation for removal of adenoids and tonsils is not so simple that anvbody and everybody who happens to have a surgical qualification and a guillotine can do it as it ought to be done; it is one which, if done, ought to be done by the most expert skill attainable."
FURTHER STUDY OF THE NEW INFECTIOUS DISEASE.
Authors: LEONARD K. HIRSHBERG
Journal: JAMA (1907)

I have already<sup>1</sup>reported 8 cases of an infectious disease hitherto undescribed in text-books or the literature. Since contributing that study, through the kindness of the authors, I have found two articles which report an analogous fever.<sup>2</sup>These reports, however, are very obscure and incomplete. They make no mention of important tests in order to exclude the various well known fevers, typhoid, etc. The cases of Dr. Sheffield occurred among children and in epidemic form. There are many points in common both in Dr. Sheffield's and Dr. Happel's cases, yet the data are so very much obscured and faulty that more complete reports must be made before these cases can be all identified as the disease reported here. Through the kindness of many of my colleagues, I am enabled in the following study to report on eleven histories of similar cases in addition to the nine of my
Care of Adolescents
Authors: J. DENNIS FORTENBERRY
Journal: Annals of Internal Medicine (1983)

Letters and Corrections1 November 1983Care of AdolescentsJ. DENNIS FORTENBERRY, M.D., DAVID W. KAPLAN, M.D., EFSTRATIOS DEMETRIOU, M.D., REBECCA J. BECKMAN, M.D., DAVID EVANS, R.N., M.S.N., C.P.N.P.J. DENNIS FORTENBERRY, M.D.Search for more papers by this author, DAVID W. KAPLAN, M.D.Search for more papers by this author, EFSTRATIOS DEMETRIOU, M.D.Search for more papers by this author, REBECCA J. BECKMAN, M.D.Search for more papers by this author, DAVID EVANS, R.N., M.S.N., C.P.N.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-99-5-739_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The article by Rapp (1) turns welcome attention to a subject infrequently addressed by the literature on adult medicine, even though internal-medicine residents and practitioners care for adolescents in various ambulatory-care settings (2). Several points require comment.Issues of confidentiality and autonomy are of great importance in dealing with adolescent patients; Hoffman (3) has addressed several of these issues and concludes that "no barriers should be placed in the way of rendering minor adolescents important preventative or therapeutic health services. . . ." Rapp's statement "parental consent should be obtained" suggests an overly tentative attitude toward this...References1. RAPP C. The adolescent patient. Ann Intern Med. 1983;99:52-60. LinkGoogle Scholar2. The National Ambulatory Medical Care Survey, United States, 1979 Summary. Hyattsville, Maryland: National Center for Health Statistics, 1982. (Vital and health statistics; series 13; no. 66.) Google Scholar3. HOFFMAN A. A rational policy toward consent and confidentiality in adolescent health care. J Adolesc Health Care 1980;1:9-17. CrossrefMedlineGoogle Scholar4. MUUSS R. Theories of Adolescence. New York: Random House; 1975:211. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Oklahoma Health Sciences Center Oklahoma City, OK 73190 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1983Volume 99, Issue 5Page: 739-739KeywordsAdolescentsMedical services Issue Published: 1 November 1983 PDF DownloadLoading ...
Anthrax blamed as two postal workers die in United States
Authors: F. Charatan
Journal: BMJ (2001)

Two US postal workers who handled mail at an office where a letter contaminated with anthrax was sorted are suspected to have died from the disease. As the BMJ went to press this week, tests were being carried out on the men who died in what officials called “highly suspicious circumstances.”

The cases, if confirmed, would bring the number of deaths to three since the first …
Response to Letter Regarding Articles, “Increasing Use of Cardiopulmonary Resuscitation During Out-of-Hospital Ventricular Fibrillation Arrest: Survival Implications of Guideline Changes” and “Measuring Progress in Resuscitation: It’s Time for a Better Tool”
Authors: Thomas D. Rea, Michele Garcia, Mickey Eisenberg, Michael Helbock, Stephen Perry, Don Cloyd, Linda Becker
Journal: Circulation (2007)
Safety of performing fiberoptic bronchoscopy in critically ill hypoxemic patients with acute respiratory failure
Authors: Christophe Cracco, Muriel Fartoukh, Hélène Prodanovic, Elie Azoulay, Cécile Chenivesse, Christine Lorut, Gaëtan Beduneau, Hoang Nam Bui, Camille Taille, Laurent Brochard, Alexandre Demoule, Bernard Maitre
Journal: Intensive Care Medicine (2012)