The Management of Lupus Nephritis
Authors: ALFRED D. STEINBERG
Journal: Annals of Internal Medicine (1970)

Editorials1 December 1970The Management of Lupus NephritisALFRED D. STEINBERG, M.D., JOHN L. DECKER, M.D., F.A.C.P.ALFRED D. STEINBERG, M.D.Search for more papers by this author, JOHN L. DECKER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-73-6-1035 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe contribution of Baldwin and co-workers, published elsewhere in this issue of the ANNALS, emphasizes again the importance of the renal histological findings in guiding the therapy of the nephritis of systemic lupus erythematosus. Unfortunately such results from many centers have not been presented in standardized form and are thus often difficult to compare. But it is clear that many patients present with a limited lesion, local, focal glomerular inflammation hereafter referred to as "glomerulitis," which does not appear to require treatment beyond that given to control the extrarenal manifestations. Unless glomerulitis is similarly defined by all, results obtained in...References1. KOFFLERSCHURKUNKEL DPH: Immunological studies concerning the nephritis of systemic lupus erythematosus. J Exp Med 126:607-623, 1967 CrossrefMedlineGoogle Scholar2. POLLAKPIRANISCHWARTZ VCF: The natural history of the renal manifestations of systemic lupus erythematosus. J Lab Clin Med 63:537-550, 1964 MedlineGoogle Scholar3. SCHURSANDSON PJ: Immunologic factors and clinical activity in systemic lupus erythematosus. New Eng J Med 278: 533-538, 1968 CrossrefMedlineGoogle Scholar4. POLLAKPIRANIKARK VCR: Effect of large doses of prednisone on the renal lesions and life span of patients with lupus glomerulonephritis. J Lab Clin Med 57:495-511, 1961 MedlineGoogle Scholar5. DUBOIS E: Results of steroid therapy in systemic lupus erythematosus, in Lupus Erythematosus, edited by DUBOIS EL. New York, McGraw-Hill Book Co., Inc., 1966, pp. 388-402 Google Scholar6. RUSSELLHICKS PJ: Cyclophosphamide treatment of renal disease in (NZB X NZW) F1 hybrid mice. Lancet 1:440-446, 1968 CrossrefMedlineGoogle Scholar7. DUBOIS E: Management of discoid and systemic lupus erythematosus, in Lupus Erythematosus, edited by DUBOIS EL. New York, McGraw-Hill Book Co., Inc., 1966, pp. 340-387 Google Scholar8. MAHERSCHREINER JG: Treatment of lupus nephritis with azathioprine. Arch Intern Med (Chicago) 125:293-298, 1970 CrossrefMedlineGoogle Scholar9. STEINBERGKALTREIDERSTAPLES AHP: Controlled trial of cyclophosphamide in systemic lupus erythematosus nephritis. Arthritis Rheum 13:351, 1970 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: National Institute of Arthritis and Metabolic Diseases Bethesda, Md. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByLong-term follow-up of patients with lupus nephritisThe effect of normalization of serum complement and anti-DNA antibody on the course of lupus nephritisPsychopathology in systemic lupus erythematosus. II. Relation to clinical observations, corticosteroid administration, and cerebrospinal fluid C4Therapeutic studies in NZB/W mice. I. Synergy of azathioprine, cyclophosphamide and methylprednisolone in combinationCyclophosphamide in Lupus Nephritis: A Controlled TrialALFRED D. STEINBERG, M.D., H. BENFER KALTREIDER, M.D., PARKER J. STAPLES, M.D., EDWARD J. GOETZL, M.D., NORMAN TALAL, M.D., JOHN L. DECKER, M.D., F.A.C.P. 1 December 1970Volume 73, Issue 6Page: 1035-1036KeywordsGlomerulonephritisInflammationLesionsLupus erythematosusLupus nephritisNephritis Issue Published: 1 December 1970 PDF DownloadLoading ...