tbuckley/cabot-search huggingface dataset:
Progression of alcoholic acute to chronic pancreatitis.
Authors: R W Ammann, B Muellhaupt
Journal: Gut (1994)

Alcoholic chronic pancreatitis usually progresses from acute attacks to chronic pancreatitis within one to 19 years. The factors responsible for the appreciable variability in progression are unclear. In this study the relation between progression and the incidence and severity of acute episodes in a large cohort of patients with alcoholic chronic pancreatitis was analysed. All patients with at least one documented episode of acute pancreatitis have been studied prospectively over the past 30 years according to our protocol. Patients were classified according to their long term course into (a) calcific (n = 185), (b) non-calcific (n = 30), and (c) non-progressive (n = 39) chronic pancreatitis groups. The yearly incidence of acute attacks of pancreatitis was significantly higher in groups (a) and (b) than in group (c). Furthermore, the progression rate to advanced chronic pancreatitis (groups (a) and (b)) correlated with the incidence of severe pancreatitis (associated with pseudocysts in more than 55%). Pseudocysts were located primarily in the cephalic pancreas in groups (a) and (b) (58-71%) and in the pancreatic tail in group (c) (61%). In conclusion, these data suggest that the progression of acute to chronic pancreatitis is closely related to the incidence and severity of acute attacks. This finding and the primary location of pseudocysts in the cephalic pancreas (groups (a) plus (b)) are compatible with the 9necrosis-fibrosis9 pathogenetic hypothesis.
Situating situated multimodal perception: The relevance of global arrays to development
Authors: David J. Lewkowicz, Christian Scheier
Journal: Behavioral and Brain Sciences (2001)

Stoffregen &amp; Bardy reject the likelihood that infants are sensitive to the global array, implying that intersensory integration is not possible in early development. We argue that infants are sensitive to unimodal arrays and are able to integrate them through the active participation of their nervous system and that the observed developmental changes are due to experience and brain development.
Plasma Glutathione <b> <i>S</i> </b>-Transferase P1-1 as a Prognostic Factor in Patients with Advanced Non-Hodgkin’s Lymphoma (Stages III and IV)
Authors: Tatsuro Katahira, Tetsuji Takayama, Koji Miyanishi, Tsuyoshi Hayashi, Tatsuru Ikeda, Yasuo Takahashi, Rishu Takimoto, Takuya Matsunaga, Junji Kato, Yoshiro Niitsu
Journal: Clinical Cancer Research (2004)

This study aims to investigate whether the plasma level of glutathione S-transferase P1-1 (GSTP1-1), which is a phase II detoxifying enzyme known to be a resistance factor for anticancer drugs, could be a prognostic factor of de novo non-Hodgkin lymphoma (NHL) in clinical stages (CSs) III and IV.Study population consisted of 80 NHL patients with no prior treatment: 12 patients were at CS I, 14 at CS II, 25 at CS III, and 29 at CS IV. All 54 patients at CS III or CS IV were treated with cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP). Plasma GSTP1-1 concentration was measured by ELISA. We stained lymph node tissues for GSTP1-1 using anti-GSTP1-1 monoclonal antibody 5F and quantitatively assessed the intensity of immunostaining by using the KS-400 image analyzing system.There was a significant stepwise increment of plasma GSTP1-1 concentration from CS I to CS IV (P < 0.05). Of the 54 patients with CS III or IV treated with CHOP, 28 (52%) had elevated plasma GSTP1-1 levels. Plasma GSTP1-1 concentration tended to correlate with the intensity of GSTP1-1 expression in lymphoma tissues as assessed by immunostaining (P = 0.07). The CR rates in patients at CS III and CS IV treated by CHOP, 55.2% (14 of 26) and 16.0% (5 of 28) for the low and high plasma GSTP1-1 groups, respectively, were significantly different (P < 0.01). For these two groups, the median survival times were 64 and 25 months, respectively (P < 0.01), and the median times to progression were 58 and 12 months, respectively (P < 0.01). There was no significant correlation between plasma GSTP1-1 concentrations and other NHL prognostic indicators in these patients as determined by univariate and multivariate analyses.These results showed that plasma GSTP1-1 is a useful prognostic factor for CS III and IV advanced NHL. Thus, it may be a promising strategy to treat NHL concomitantly with anticancer drugs and GSTP1-1-specific inhibitors.
Therapeutic role of dual inhibitors of 5-LOX and COX, selective and non-selective non-steroidal anti-inflammatory drugs
Authors: J Martel-Pelletier
Journal: Annals of the Rheumatic Diseases (2003)

Dual 5-LOX/COX inhibitors are potential new drugs to treat inflammation. They act by blocking the formation of both prostaglandins and leucotrienes but do not affect lipoxin formation. Such combined inhibition avoids some of the disadvantages of selective COX-2 inhibitors and spares the gatrointestinal mucosa.
Molecular Dissection of Microsatellite Instable Colorectal Cancer
Authors: Eduardo Vilar, Josep Tabernero
Journal: Cancer Discovery (2013)

Colorectal cancer was one of the first solid tumors to be classified on the basis of molecular profiling. Microsatellite instability has allowed researchers to distinguish a specific subtype of colorectal cancer that has a clearly identified molecular origin (mismatch repair deficiency), arises on a hereditary and sporadic basis, is linked to a clear clinicopathologic profile, and has prognostic implications. Inconclusive predictive data along with a paucity of targeted drug development have prevented this molecular classification system from being implemented in the clinical setting. New high-throughput genomic data have validated it, thus stressing the fact that it is ready to be applied clinically.Application of a molecular classification of colorectal cancer in the clinical arena is an unmet promise. Recent results of large-scale genomic analyses have provided confirmation and further insights into the molecular biology of already known colorectal cancer subgroups. The quintessential example is the microsatellite instability subgroup, which has been well characterized during the past 2 decades. Future drug development and clinical research initiatives in colorectal oncology should consider these and other known cancer subgroups and start targeting these selected patient populations.
A Blood-Resistant Surgical Glue for Minimally Invasive Repair of Vessels and Heart Defects
Authors: Nora Lang, Maria J. Pereira, Yuhan Lee, Ingeborg Friehs, Nikolay V. Vasilyev, Eric N. Feins, Klemens Ablasser, Eoin D. O’Cearbhaill, Chenjie Xu, Assunta Fabozzo, Robert Padera, Steve Wasserman, Franz Freudenthal, Lino S. Ferreira, Robert Langer, Jeffrey M. Karp, Pedro J. del Nido
Journal: Science Translational Medicine (2014)

A light-activated, biodegradable adhesive seals cardiovascular defects in the presence of blood flow and could be useful during minimally invasive surgery.
A homozygous cathepsin C mutation associated with Haim-Munk syndrome
Authors: V.F. Cury, R.S. Gomez, J.E. Costa, E. Friedman, W. Boson, L. De Marco
Journal: British Journal of Dermatology (2005)

Haim–Munk syndrome (HMS) is a rare autosomal recessive disorder characterized clinically by abnormal palmoplantar hyperkeratosis and destruction of the periodontium, with hallmarks of onychogryphosis and arachnodactyly. Germline mutations in the lysosomal protease cathepsin C gene (CTSC) have been described in a single patient with HMS and in several individuals with the clinically related disorder Papillon–Lefèvre syndrome (PLS). We describe a patient with HMS. We have analysed the cathepsin C gene in the proband and her mother. Sequence analysis of CTSC in the proband revealed a homozygous mutation at codon 196 (587T→C) within exon 4 that altered the conserved leucine to proline (Leu196Pro), whereas the patient's mother was heterozygous for that mutation. The same mutation has previously been described in an unrelated Brazilian family with PLS. An identical single missense mutation in the cathepsin C gene may underlie both PLS and HMS. These findings confirm that HMS and PLS are allelic variants of cathepsin C gene mutations and suggest that other factors (environmental or genetic) may be important determinants of the clinical phenotype of HMS and PLS.
Rubella antibody levels in juvenile rheumatoid arthritis.
Authors: C.C Linnemann, J.E Levinson, C.R Buncher, G.M Schiff
Journal: Annals of the Rheumatic Diseases (1975)

Increased rubella antibody titres have been reported in patients with juvenile rheumatoid arthritis (JRA) and it has been suggested that rubella virus may be of importance in the aetiology or pathogenesis of the disease. In the present study, rubella and rubeola antibody titres in 85 patients with JRA were compared to age- and sex-matched controls. 41% of the patients did not have rubella antibody, but the geometric mean titre of those with JRA who had antibody was slightly higher than that of the controls with antibody (58-9 against 42-7; P less than 0-05). The level of rubella antibody titre correlated with serum IgG levels. There was no difference in rubeola antibody titres between patients and controls, and rubeola antibody did not correlate with serum IgG. Fifteen JRA patients developed rubella antibody after rubella vaccine or natural disease. This did not result in unusually high antibody titres and was associated with a mild exacerbation of symptoms in only two patients. This study suggests that the slight increase in rubella antibody in JRA is a nonspecific manifestation of increased immunoglobulins.
Intensive Insulin Therapy in the Intensive Care Unit: Assessment by Continuous Glucose Monitoring
Authors: Regis P. Radermecker
Journal: Diabetes Care (2006)

I read with interest the article by De Block et al. (1). Indeed, reliable devices recording continuously interstitial glucose concentrations (IGCs) may be an alternative to frequent glucose monitoring, especially in patients of intensive care units (ICUs) in whom normoglycemia has become a major target. However, all factors influencing the complex kinetics of IGCs should be understood before considering continuous glucose monitoring (CGM) as a valuable and accurate alternative to track hyperglycemia and adapt …
Demographic features of patients submitted for smoking cessation and the success rate of pharmacological therapy
Authors: Hakan Tanriverdi, Murat Altuntas, Ozgür Demir, Bilgen Begüm Afsar, Metin Çelikiz
Journal: European Respiratory Journal (2013)

INTRODUCTION: Smoking is the most important cause of early dead and preventable diseases.  AIM: We aimed to investigate demographic features of all patients that submitted for smoking cessation polyclinic for a one year period and to see successes of therapies.   MATERIAL-METHODS:    All patients submitted for smoking cessation in year of 2012 were included to study. Demographic data of patients like age, gender, number of cigarettes per day, score of Fagerstrom nicotin addiction test, carbon monoxide levels and given therapies were recorded. Patients who received nicotin replacement therapy and pharmocological therapy(bupropion or vareniklin) were included study.   RESULTS:  933 male, 413 female total 1346 patients submitted to smoking cessation polyclinic.  609 patients received nicotin replacement therapy,184 patients received vareniklin and 423 patients received bupropion. We reached 721 patients.272 of 721 patients (37,7%) quitted smoking during the therapy. But 31% of these patients started smoking after therapy finished. Smoking quitting rate of patients received vareniklin, bupropion and nicotin replacement therapy were 31% (32 of 104 patients), 26% (66 of 262 patients),and 25% (88 of 355 patients) respectively.   CONCLUSION:  smoking is a serious public health problem that should not be neglected.
Infants with acute lymphoblastic leukemia and a germline MLL gene are highly curable with use of chemotherapy alone: results from the Japan Infant Leukemia Study Group
Authors: Jun Nagayama, Daisuke Tomizawa, Katsuyoshi Koh, Yoshihisa Nagatoshi, Noriko Hotta, Tomoko Kishimoto, Yoshihiro Takahashi, Tomoko Kuno, Kanji Sugita, Takashi Sato, Kohji Kato, Atsushi Ogawa, Tatsutoshi Nakahata, Shuki Mizutani, Keizo Horibe, Eiichi Ishii
Journal: Blood (2006)
The Therapeutics of Heat and Light and Electric Heat and Light Baths
Authors: H. L. Jones
Journal: BMJ (1899)

recorded by Jomini.I have elsewhere1 analysed this case, which is probably one of gross congenital abnormality, with secondary adhesion processes.It cannot be allowed as a hernia of this class.The only two authentic cases, so far as I am aware, are recorded-the first by Mr. F. S. Eve, and the second by Mr.
Incomplete Cd8+ T Lymphocyte Differentiation as a Mechanism for Subdominant Cytotoxic T Lymphocyte Responses to a Viral Antigen
Authors: Juliet V. Spencer, Thomas J. Braciale
Journal: The Journal of Experimental Medicine (2000)

CD8+ cytotoxic T lymphocytes (CTLs) recognize antigen in the context of major histocompatibility complex (MHC) class I molecules. Class I epitopes have been classified as dominant or subdominant depending on the magnitude of the CTL response to the epitope. In this report, we have examined the in vitro memory CTL response of H-2d haplotype murine CD8+ T lymphocytes specific for a dominant and subdominant epitope of influenza hemagglutinin using activation marker expression and staining with soluble tetrameric MHC–peptide complexes. Immune CD8+ T lymphocytes specific for the dominant HA204-210 epitope give rise to CTL effectors that display activation markers, stain with the HA204 tetramer, and exhibit effector functions (i.e., cytolytic activity and cytokine synthesis). In contrast, stimulation of memory CD8+ T lymphocytes directed to the subdominant HA210-219 epitope results in the generation of a large population of activated CD8+ T cells that exhibit weak cytolytic activity and fail to stain with the HA210 tetramer. After additional rounds of restimulation with antigen, the HA210-219–specific subdominant CD8+ T lymphocytes give rise to daughter cells that acquire antigen-specific CTL effector activity and transition from a HA210 tetramer–negative to a tetramer-positive phenotype. These results suggest a novel mechanism to account for weak CD8+ CTL responses to subdominant epitopes at the level of CD8+ T lymphocyte differentiation into effector CTL. The implications of these findings for CD8+ T lymphocyte activation are discussed.
Colorectal leukotriene B4 synthesis in vitro in inflammatory bowel disease: inhibition by the selective 5-lipoxygenase inhibitor BWA4C.
Authors: A B Hawthorne, N K Boughton-Smith, B J Whittle, C J Hawkey
Journal: Gut (1992)

The in vitro synthesis of leukotriene B4 (LTB4) was evaluated in colorectal biopsy specimens and resection tissue from patients with inflammatory bowel disease. The in vitro formation of LTB4 from biopsy tissues stimulated with calcium ionophore A23187 correlated with the degree of mucosal inflammation assessed at sigmoidoscopy, and with neutrophil infiltration measured as myeloperoxidase activity. Biopsy specimens from patients taking prednisolone formed less LTB4 than those from patients not on prednisolone, with comparable levels of inflammation seen at sigmoidoscopy. The formation of LTB4 was reduced dose-dependently by the acetohydroxamic acid 5-lipoxygenase inhibitor BWA4C, with no significant inhibition of prostaglandin E2 or thromboxane B2 synthesis. In inflamed colonic resection tissue from colitic patients, the IC50 for inhibition of LTB4 formation by BWA4C was 0.03 mumol/l, compared with an IC50 of 0.8 mumol/l for NDGA. Thus, BWA4C is a potent and selective inhibitor of LTB4 synthesis in colonic tissue from patients with ulcerative colitis. Acetohydroxamic acid 5-lipoxygenase inhibitors, exemplified by BWA4C, may be useful to evaluate the clinical importance of LTB4 in ulcerative colitis, and offer a novel therapy for the disease.
Abnormal regional cerebral blood flow on 99mTc ECD brain SPECT in patients with primary Sjogren's syndrome and normal findings on brain magnetic resonance imaging
Authors: C P Chang
Journal: Annals of the Rheumatic Diseases (2002)

<b>Objective:</b> Technetium-99m ethyl cysteinate dimer (<sup>99m</sup>Tc ECD) single photon emission computed tomography (SPECT) of the brain was used to detect abnormal regional cerebral blood flow (rCBF) in patients with primary Sjögren9s syndrome (pSS) and normal findings on brain magnetic resonance imaging (MRI). <b>Methods:</b><sup>99m</sup>Tc ECD brain SPECT was performed to detect brain lesions showing hypoperfusion in 32 female patients with pSS and definite neuropsychiatric symptoms or signs. Seventeen female patients with pSS without neuropsychiatric symptoms and signs were included as a control group for comparison. All of the 49 patients with pSS had normal findings on brain MRI. <b>Results:</b><sup>99m</sup>Tc ECD brain SPECT showed brain regions with hypoperfusion in 18 (56.3%) of the 32 patients, and parietal lobes were the most common areas with such lesions. By contrast, <sup>99m</sup>Tc ECD brain SPECT showed brain regions with hypoperfusion in only three (17.6%) of the 17 patients with pSS without neuropsychiatric symptoms or signs. <b>Conclusion:</b> This study suggests that <sup>99m</sup>Tc ECD SPECT is a sensitive tool for detecting regions of hypoperfusion in the brains of patients with pSS and neuropsychiatric symptoms or signs and normal findings on brain MRI. However, a review of the literature showed that the <sup>99m</sup>Tc ECD SPECT findings in patients with pSS were non-specific.
Associations Between Obsessive-Compulsive Classes and Pathological Gambling in a National Cohort of Male Twins
Authors: Jeffrey F. Scherrer, Hong Xian, Wendy S. Slutske, Seth A. Eisen, Marc N. Potenza
Journal: JAMA Psychiatry (2015)

<h3>Importance</h3> Because of shared characteristics, pathological gambling (PG) has been variously conceptualized as an obsessive-compulsive (OC) spectrum disorder or as an addictive disorder. Prior community-based studies have not systematically determined the association between PG and OC features and whether common genetic factors contribute to both conditions. <h3>Objective</h3> To examine the association and genetic correlation between PG and OC features. <h3>Design, Setting, and Participants</h3> We performed a latent class analysis (LCA) of OC features, cross-sectional tests of association, and classic twin genetic analysis using results of telephone interviews conducted from March 2002 through November 2003. Participants included 1675 male twin pairs from the Vietnam Era Twin Registry, aged 45 to 60 years. <h3>Main Outcomes and Measures</h3> Ten OC features were queried and used to derive OC classes identified via LCA. <h3>Results</h3> The best-fitting LCA model identified the following 4 OC classes: unaffected (class 1), ritual/symmetry compulsions (class 2), germ/contamination obsessions (class 3), and severe OC (class 4). All PG symptoms were more common in class 4 OC and 6 of 10 PG symptoms were significantly more common in class 4 OC (<i>P</i> &lt; .01). Participants in the severe class were most likely to have 4 or more<i>DSM-IV</i>or<i>DSM-5</i>PG diagnostic criteria (odds ratio, 3.8 [95% CI, 1.8-8.2]). The genetic correlation between phenotypes was 0.44 (95% CI, 0.16-0.75). <h3>Conclusions and Relevance</h3> The association between OC features and diagnostic criteria for PG highlights a role of obsessions and compulsivity in PG, and the lifetime co-occurrence of these disorders results in part from common genetic variance. Phenotypic and genetic overlap between OC features and PG add to our understanding of the most appropriate classification of PG and offers insights for treatment development.
Embryo culture media and IVF/ICSI success rates: a systematic review
Authors: E. Mantikou, M.A.F.M. Youssef, M. van Wely, F. van der Veen, H.G. Al-Inany, S. Repping, S. Mastenbroek
Journal: Human Reproduction Update (2013)

The media that are used to culture human preimplantation embryos are considered to be an important factor for the success rates of IVF/ICSI. Here, we present a systematic review of randomized controlled trials (RCTs) on the effect of culture media on IVF/ICSI success rates. RCTs published between January 1985 and July 2012 were eligible for inclusion. The primary outcome was live birth. Secondary outcomes were health of babies born, ongoing pregnancies, clinical pregnancies, miscarriages, multiple pregnancies, implantation rate, cryopreservation rate, embryo quality and fertilization rate. For those media that were evaluated in more than one comparison, an unconventional meta-analysis was performed by pooling the data of the media they were compared to. Twenty-two RCTs were included that evaluated 31 different comparisons. Conventional meta-analysis was not possible for any of the outcomes as nearly all trials compared different culture media. Only four trials reported on live birth, and one of them reported a significant difference. Nine trials reported on ongoing and/or clinical pregnancy rates, of which four showed a significant difference. Pooling the data did not reveal a superior culture medium. It is yet unknown what culture medium leads to the best success rates in IVF/ICSI. Given the potential importance of culture media for treatment outcome, rigorously designed RCTs are needed for currently available, as well as newly introduced culture media.
Cardiovascular outcomes in high risk patients with osteoarthritis treated with ibuprofen, naproxen or lumiracoxib
Authors: M E Farkouh, J D Greenberg, R V Jeger, K Ramanathan, F W A Verheugt, J H Chesebro, H Kirshner, J S Hochman, C L Lay, S Ruland, B Mellein, P T Matchaba, V Fuster, S B Abramson
Journal: Annals of the Rheumatic Diseases (2007)

<b>Background:</b> Evidence suggests that both selective cyclooxygenase (COX)-2 inhibitors and non-selective non-steroidal anti-inflammatory drugs (NSAIDs) increase the risk of cardiovascular events. However, evidence from prospective studies of currently available COX-2 inhibitors and non-selective NSAIDs is lacking in patients at high cardiovascular risk who are taking aspirin. <b>Objective:</b> To determine the cardiovascular outcomes in high risk patients with osteoarthritis treated with ibuprofen, naproxen or lumiracoxib. <b>Methods:</b> The Therapeutic Arthritis Research and Gastrointestinal Event Trial (TARGET) of 18 325 patients with osteoarthritis comprised two parallel substudies, comparing lumiracoxib (COX-2 inhibitor) with either ibuprofen or naproxen. A post hoc analysis by baseline cardiovascular risk, treatment assignment, and low-dose aspirin use was performed. The primary composite end point was cardiovascular mortality, non-fatal myocardial infarction, and stroke at 1 year; a secondary end point was the development of congestive heart failure (CHF). <b>Results:</b> In high risk patients among aspirin users, patients in the ibuprofen substudy had more primary events with ibuprofen than lumiracoxib (2.14% vs 0.25%, p = 0.038), whereas in the naproxen substudy rates were similar for naproxen and lumiracoxib (1.58% vs 1.48%, p = 0.899). High risk patients not taking aspirin had fewer primary events with naproxen than with lumiracoxib (0% vs 1.57%, p = 0.027), but not for ibuprofen versus lumiracoxib (0.92% vs 0.80%, p = 0.920). Overall, CHF developed more often with ibuprofen than lumiracoxib (1.28% vs 0.14%; p = 0.031), whereas no difference existed between naproxen and lumiracoxib. <b>Conclusions:</b> These data suggest that ibuprofen may confer an increased risk of thrombotic and CHF events relative to lumiracoxib among aspirin users at high cardiovascular risk. The study indicates that naproxen may be associated with lower risk relative to lumiracoxib among non-aspirin users. This study is subject to inherent limitations, and therefore should be interpreted as a hypothesis-generating study.