Allopurinol-Induced Interstitial Nephritis
Authors: DAVID R. GELBART
Journal: Annals of Internal Medicine (1977)

Letters1 February 1977Allopurinol-Induced Interstitial NephritisDAVID R. GELBART, M.D., ARVIN B. WEINSTEIN, M.D., F.A.C.P., LUIS F. FAJARDO, M.D.DAVID R. GELBART, M.D.Search for more papers by this author, ARVIN B. WEINSTEIN, M.D., F.A.C.P.Search for more papers by this author, LUIS F. FAJARDO, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-86-2-196 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFour previous reports implicate allopurinol as a cause of acute renal failure in six patients (1-4). However, the renal histology in three autopsied patients was so variable that the existence of a specific allopurinol-induced renal disease has remained doubtful.We describe a patient who developed dermatitis, eosinophilia and acute renal failure after 1 month's exposure to allopurinol. Renal biopsy, obtained during the early phase of acute renal failure, demonstrated acute interstitial nephritis.After a 10-year history of schizophrenia and alcoholism this 53-year old black man presented in July 1975 with diastolic hypertension (160/100 mm Hg). Propanolol, 40 mg three times...References1. KANTOR G: Toxic epidermal necrolysis, azotemia, and death after allopurinol therapy. JAMA 212:478-479, 1970 CrossrefMedlineGoogle Scholar2. MILLS R: Severe hypersensitivity reactions associated with allopurinol. JAMA 216:799-802, 1971 CrossrefMedlineGoogle Scholar3. JARZOBSKIFERRYWOMBOLT JJD: Vasculitis with allopurinol therapy. Am Heart J 79:116-121, 1970 CrossrefMedlineGoogle Scholar4. YOUNGBOSWELLNIES JRA: Severe allopurinol hypersensitivity. Association with thiazides and prior renal compromise. Arch Intern Med 134:553-558, 1974 CrossrefMedlineGoogle Scholar5. BALDWINLEVINEMCCLUSKEY DBR: Renal failure and interstitial nephritis due to penicillin and methicillin. N Engl J Med 279:1245-1252, 1968 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine and Department of Pathology Stanford University School of Medicine Stanford, CA 94305 Veterans Administration Hospital Palo Alto, CA 94304 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByPractical Guidance for the Evaluation and Management of Drug Hypersensitivity: Specific DrugsNephrotoxicity of Select Rheumatologic DrugsPotential Role of Allopurinol in Preventing Contrast-Induced Nephropathy in Patients Undergoing Percutaneous Coronary Intervention: A Randomized Placebo-Controlled TrialGout: An old disease in new perspective – A reviewAllopurinol Hypersensitivity: A Systematic Review of All Published Cases, 1950–2012A pilot in distressHigher Therapeutic Plasma Oxypurinol Concentrations Might Be Required for Gouty Patients With Chronic Kidney DiseaseGold salts, D-penicillamine and allopurinolRenale Manifestationen rheumatischer ErkrankungenGold salts, D-penicillamine and allopurinolNephrotoxicity of gold salts, D-penicillamine, and allopurinolInterstitial causes of renal failureAllopurinol Hypersensitivity Syndrome: A ReviewReview: Acute tubulointerstitial nephritisMedikamentöse Beeinflussung von Synthese und Abbau der PurineInterstitial NephritisImmunologically Mediated Nephritis Induced by Toxins and DrugsThe allopurinol hypersensitivity syndrome. 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GOLPER, M.D., IRWIN SINGER, M.D.STRUCTURE SIDE-EFFECT SORTING OF DRUGS.Toxische Nierensch�denMedikamentöse Schäden der NiereDrug-Associated NephropathyReversible Renal Failure and Nephrotic Syndrome Associated with Nonsteroidal Anti-Inflammatory DrugsThe allopurinol hypersensitivity syndromeAllopurinol HypersensitivityAcute renal failure 1 February 1977Volume 86, Issue 2Page: 196-198KeywordsAcute renal failureAlcoholismAllopurinolBiopsyEosinophiliaHistologyHypertensionNephritisRenal diseasesSchizophrenia Issue Published: 1 February 1977 PDF DownloadLoading ...