tbuckley/cabot-search huggingface dataset:
Low-density lipoprotein apheresis retards the progression of hyperlipidemic overt diabetic nephropathy
Authors: Toshiyuki Nakao, Maki Yoshino, Hiroshi Matsumoto, Tomonari Okada, Myongi Han, Hiromi Hidaka, Tamami Shino, Chikayuki Yamada, Yume Nagaoka, Tadashi Miyahara
Journal: Kidney International (1999)
Diseases of the Heart and Blood Vessels: Nomenclature and Criteria for Diagnosis
Authors: Alvan R. Feinstein
Journal: JAMA (1964)

During 36 years, through five previous editions, this book has done more than any other single publication to provide a rational catalog of cardiovascular classification. For the new edition, the editors have secured different contributors and revised the text and format to make the book more informative and attractive, while increasing its size by almost 100 pages. The new work is an excellent embellishment of the 1953 edition, but omits many developments of the past 11 years. New diagnostic tools and therapeutic procedures have produced a nomenclature that needs classification and criteria; new techniques of data processing require specification of the undefined elements used in the old criteria. The latest edition fails to deal with many of the new and old issues whose definition and delineation produce constant clinical disagreement. No diagnostic standards are presented for such common clinical problems as malignant hypertension, coronary insufficiency (as a clinical state midway
Prise en charge endoscopique des complications de la chirurgie bariatrique
Authors: M Barthet, P Ah-Soune, T Bege, V Vitton, O Emungania, S Brardjanian, D Nocca, P Noel, C Brunet, JC Grimaud
Journal: Endoscopy (2010)

Introduction: Le traitement des fistules anastomotiques après chirurgie bariatrique demeure difficile et potentiellement létal. Il associe habituellement reprise chirurgicale, prise en charge du sepsis, et mise au repos digestif prolongé. Une nouvelle stratégie endoscopique de prise en charge a été proposée.
Chronic visceral/mesenteric ischemia: Role of percutaneous angioplasty and stenting in celiac and mesenteric artery disease
Authors: David E. Allie, Mitchell D. Lirtzman, Charles H. Wyatt, V.Antoine Keller, Mohamed H. Khan, Muhammad A. Khan, Peter S. Fail, Chris J. Hebert, Adam A. Allie, Craig M. Walker
Journal: Journal of the American College of Cardiology (2003)
Heterogeneous changes in action potential and intracellular Ca2+ in left ventricular myocyte sub-types from rabbits with heart failure
Authors: M McIntosh
Journal: Cardiovascular Research (2000)

Myocardial cellular electrophysiology and intracellular Ca2+ regulation are altered in heart failure. The extent of these changes may vary within the layers of the ventricular wall. To examine this, cell size, action potential and intracellular Ca2+ transient characteristics (Fura-2) were measured in single cardiac myocytes from sub-epicardial, mid-myocardial, and sub-endocardial regions of the left ventricle of rabbits with heart failure.Myocytes were isolated from animals with heart failure induced by chronic coronary artery ligation and from sham operated controls. Trans-membrane potential was measured using high resistance microelectrodes electrodes (30 M omega; 2 M KC1). Fura-2 was loaded into cells by incubation with the AM form. Subsequent fluorescence measurements were used to measure intracellular Ca2+ concentration at a range of stimulus frequencies.Resting cell length was significantly greater in the heart failure group; approximately 115% of control values in sub-epicardial and mid-myocardial cells, and approximately 108% in sub-endocardial cells. Using criteria described by previous studies on other mammalian hearts, functional M cells were identified by a higher maximum rate of depolarisation and longer action potential duration at 90% repolarisation (APD90) compared to the two other myocyte sub-types. In the heart failure group, APD90 and Ca2+ transient duration (CaD50) were prolonged in sub-epicardial and M cells but shortened in sub-endocardial myocytes. These changes were significant at lower stimulus frequencies, but the relative effect diminished at higher frequencies (3 Hz). Peak systolic [Ca2+] was reduced in sub-epicardial and M cells but increased in sub-endocardial cells in the heart failure group compared to controls. At higher stimulus frequencies, end diastolic Ca2+ levels were lower in sub-epicardial cells but higher in sub-endocardial myocytes of the heart failure group compared with controls. In general, changes were greater in heart failure animals with more severe in vivo ventricular dysfunction (ejection fraction < or = 44%).Heart failure was associated with an increased cell size throughout the left ventricle, but the form of the changes in electrophysiology and Ca2+ transient were dependent on the myocyte sub-type. In particular sub-endocardial cells displayed markedly different changes compared to the other myocyte sub-types.
Abstract 3232: Optimization of a potent stapled helix peptide that binds to Replication Protein A
Authors: Alex G. Waterson, Andreas O. Frank, Bhavatarini Vandgamudi, Michael D. Feldkamp, Elaine M. Souza-Fagundes, Jessica W. Luzwick, David Cortez, Edward T. Olejniczak, Olivia W. Rossanese, Walter J. Chazin, Stephen W. Fesik
Journal: Cancer Research (2014)

Abstract Replication Protein A (RPA) is a major regulator of checkpoint activation and enhanced DNA repair in cancer cells. In response to genotoxic stress, the RPA complex binds to and protects ssDNA while serving as a scaffold to recruit critical checkpoint and DNA-damage response proteins through the N-terminal region of the 70 kDa subunit of RPA (RPA70N). Specific disruption of the protein-protein interactions mediated by the RPA70N domain has the potential to produce selective killing of cancer cells without the risk of cytotoxicity due to interference in the ssDNA-binding function. Stapled helix peptides can serve as useful tools for inhibiting protein-protein interactions. However, their utility can be limited due to difficulties often encountered during attempts to improve the binding affinity to the target. Here, we report the discovery and optimization of a potent stapled helix peptide probe, derived from the endogenous RPA binding partner ATRIP (ATR-interacting protein), that binds to and inhibits the RPA70N protein-protein interaction surface. Alanine scanning, charge abrogation, and rational sequence optimization resulted in a peptide with a 100-fold potency gain over the native sequence and improved physical characteristics. In addition to the application of these traditional strategies, we describe a novel approach for efficiently designing peptides containing unnatural amino acids. This method involves the incorporation of an unnatural amino acid inspired by the structure activity relationships of small molecules that bind to the same site on the protein. Use of this approach produced stapled peptides with dramatic increases in binding affinity to RPA70N relative to aooIn al peptide containing only natural amino acids. The optimized peptides are cell penetrant, able to enter the nucleus, and co-localize with RPA in the nucleus at sites of DNA damage. Such a peptide may serve as a probe molecule to explore both the effects of RPA inhibition on the DNA damage response and the therapeutic potential of RPA inhibition as a cancer target. Citation Format: Alex G. Waterson, Andreas O. Frank, Bhavatarini Vandgamudi, Michael D. Feldkamp, Elaine M. Souza-Fagundes, Jessica W. Luzwick, David Cortez, Edward T. Olejniczak, Olivia W. Rossanese, Walter J. Chazin, Stephen W. Fesik. Optimization of a potent stapled helix peptide that binds to Replication Protein A. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3232. doi:10.1158/1538-7445.AM2014-3232
Intracardiac E.C.G. in pacemaker electrode insertion.
Authors: K. Chatterjee, R. Sutton
Journal: BMJ (1968)

MEDICALJOTUNAlthe rat uterus, but when given after isoprenaline the action is reversed and the uterus contracts.2It may be supposed that in a severe attack of asthma the patient is alarmed and is secreting adrenaline which would normally relax the bronchioles; if an excess of isoprenaline has been taken the effect of adrenaline will be reversed, leading to bronchoconstriction, and making death more likely.The prolonged use of isoprenaline might therefore defeat its own ends.It is not known what effects corticosteroids have on the action of catecholamines.Research on all these questions is urgently needed.
Disturbance of sensation after mastectomy.
Authors: R Downing, C W Windsor
Journal: BMJ (1984)

Disturbance of sensation after mastectomyClinicians may dismiss disturbance of sensation after mastectomy in the follow up of patients with breast cancer, but symptoms such as numbness of the upper arm and phantom breast are a common cause of anxiety for these women,' who have often received inadequate preoperative counselling.2We have therefore studied the nature and prevalence of postmastectomy symptoms and their relation to disease staging.
Comparative study of the impact of chronic urticaria, psoriasis and atopic dermatitis on the quality of life
Authors: J.J. Grob, J. Revuz, J.P. Ortonne, P. Auquier, G. Lorette
Journal: British Journal of Dermatology (2005)

Journal Article Comparative study of the impact of chronic urticaria, psoriasis and atopic dermatitis on the quality of life Get access J.J. Grob, J.J. Grob Service de Dermatologie, Hôpital Ste Marguerite, 270 Bd Ste Marguerite, 13009 Marseille, France *Service de Dermatologie, Hôpital Henri Mondor, Créteil, France †Service de Dermatologie, Hôpital Larchet 2, Nice, France ‡Service de Santé Publique, Faculté Timone, Marseille, France §Service de Dermatologie, Hôpital Trousseau, Tours, France Prof. J.J.Grob. E‐mail: jean‐jaques.grob@ap‐hm.fr Search for other works by this author on: Oxford Academic Google Scholar J. Revuz, J. Revuz Service de Dermatologie, Hôpital Ste Marguerite, 270 Bd Ste Marguerite, 13009 Marseille, France *Service de Dermatologie, Hôpital Henri Mondor, Créteil, France †Service de Dermatologie, Hôpital Larchet 2, Nice, France ‡Service de Santé Publique, Faculté Timone, Marseille, France §Service de Dermatologie, Hôpital Trousseau, Tours, France Search for other works by this author on: Oxford Academic Google Scholar J.P. Ortonne, J.P. Ortonne Service de Dermatologie, Hôpital Ste Marguerite, 270 Bd Ste Marguerite, 13009 Marseille, France *Service de Dermatologie, Hôpital Henri Mondor, Créteil, France †Service de Dermatologie, Hôpital Larchet 2, Nice, France ‡Service de Santé Publique, Faculté Timone, Marseille, France §Service de Dermatologie, Hôpital Trousseau, Tours, France Search for other works by this author on: Oxford Academic Google Scholar P. Auquier, P. Auquier Service de Dermatologie, Hôpital Ste Marguerite, 270 Bd Ste Marguerite, 13009 Marseille, France *Service de Dermatologie, Hôpital Henri Mondor, Créteil, France †Service de Dermatologie, Hôpital Larchet 2, Nice, France ‡Service de Santé Publique, Faculté Timone, Marseille, France §Service de Dermatologie, Hôpital Trousseau, Tours, France Search for other works by this author on: Oxford Academic Google Scholar G. Lorette G. Lorette Service de Dermatologie, Hôpital Ste Marguerite, 270 Bd Ste Marguerite, 13009 Marseille, France *Service de Dermatologie, Hôpital Henri Mondor, Créteil, France †Service de Dermatologie, Hôpital Larchet 2, Nice, France ‡Service de Santé Publique, Faculté Timone, Marseille, France §Service de Dermatologie, Hôpital Trousseau, Tours, France Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 152, Issue 2, 1 February 2005, Pages 289–295, https://doi.org/10.1111/j.1365-2133.2005.06385.x Published: 01 February 2005 Article history Accepted: 10 June 2004 Published: 01 February 2005
A Phase II double blind placebo-controlled multicenter study of the anti-PDGF-β-R Dl-Fab'-PEG conjugate CDP860 (25 mg/kg) dosed intravenously in patients undergoing elective coronary stent placement
Authors: Patrick W. Serruys, Guy Heyndrickx, Hans Bonnier, Matty Vrolix, Frank Van den Branden, Victor Legrand, Claude Hanet, Hans Te Riele, Michael Vandormael, Ivan De Scheerder
Journal: Journal of the American College of Cardiology (2002)
The calcimimetic compound NPS R-568 suppresses parathyroid cell proliferation in rats with renal insufficiency. Control of parathyroid cell growth via a calcium receptor.
Authors: M Wada, Y Furuya, J Sakiyama, N Kobayashi, S Miyata, H Ishii, N Nagano
Journal: Journal of Clinical Investigation (1997)

Parathyroid (PT) cell hyperplasia is a common consequence of chronic renal insufficiency (CRI). NPS R-568 is a phenylalkylamine compound that acts as an agonist (calcimimetic) at the cell surface calcium receptor (CaR). To test the hypothesis that the CaR plays a role in PT hyperplasia in CRI, we tested the effect of NPS R-568 on PT cell proliferation in rats with renal insufficiency. Rats were subjected to 5/6 nephrectomy and then infused intraperitoneally with 5-bromodeoxyuridine (BrdU) to label S-phase cells. Two groups of nephrectomized rats received NPS R-568 by gavage twice daily for 4 d (1.5 and 15 mg/kg body wt). On day 5, the number of BrdU-positive PT cells of vehicle-treated nephrectomized rats was 2.6-fold greater than that of the sham-operated control. Low and high doses of NPS R-568 reduced the number of BrdU-positive PT cells by 20 and 50%, respectively. No changes in staining, however, were observed in ileal epithelial cells (CaR-negative) or in thyroidal C-cells (CaR-positive). Furthermore, the effect of NPS R-568 could not be explained by changes in serum 1,25(OH)2D3 or phosphorus. These results indicate that NPS R-568 suppresses PT cell proliferation in rats with renal insufficiency, and lend support to the linkage between the CaR and PT hyperplasia in CRI.
The Academic Medical Center and the health of the public
Authors: G. Wittig
Journal: JAMA (1992)

<h3>In Reply.</h3> —We thank Drs Gellert and Wittig for their comments and agree with much of what they say. Their letters highlight two areas that academic health centers have not addressed adequately: the discontinuity between the programs in academic health centers and the needs of local populations and the disincentives toward primary care training and practice. Incentives toward high cost, tertiary, hospital-based treatment, and training at the expense of care of persons in the community are a general problem; Health of the Public focuses on academic health centers because of their pivotal role in influencing the attitudes and careers of future health professionals, and because their prestige and authority could serve as a potent ally in the struggle for community health. Dr Gellert asks for specifics and "operationally implementable recommendations." The objectives proposed in our article are general tenets that address the current imbalance in the education, patient care, and
The Hawksley random zero sphygmomanometer. Instrument is accurate if used properly.
Authors: W E Miall
Journal: BMJ (1993)

Results of different studies examining accuracy of Hawksley random zero sphygmomanometer compared with standard mercury sphygnomanometer.Three groups presented results as the mean differences between the two instruments; the two others reported the range ofdifference Systolic Diastolic pressure (mm Hg) pressure Study Measurement given (mm Hg) Phase IV Phase V No of subjects Evans and Prior-2 Mean difference -1-2 -22 906
Synthesis of granulocyte colony-stimulating factor and its requirement for terminal divisions in chronic myelogenous leukemia.
Authors: H Klein, R Becher, M Lübbert, W Oster, E Schleiermacher, M A Brach, L Souza, A Lindemann, R H Mertelsmann, F Herrmann
Journal: The Journal of Experimental Medicine (1990)

In this paper we demonstrate that maturing neoplastic cells from patients with chronic myelogenous leukemia (CML) constitutively produce G-CSF and are also receptive for this molecule. G-CSF functions as an autocrine growth factor in stable phase CML, and thus is responsible for divisions of maturing leukemic cells leading to an expansion of the compartment of mature cells. This observation is well in line with in vivo features of CML in stable phase, i.e., the hyperplasia of the mature granulocyte compartment. In acute blastic phase of CML expression of the G-CSF gene seems to be less common and not related to autonomous blast growth.
Genetic evidence for a role of IL33 in nasal polyposis
Authors: I. D. Buysschaert, V. Grulois, P. Eloy, M. Jorissen, P. Rombaux, B. Bertrand, S. Collet, S. Bobic, S. Vlaminck, P. W. Hellings, D. Lambrechts
Journal: Allergy (2009)

Little is known about the genetic factors that contribute to nasal polyposis (NP). A genome-wide association study identified 10 single nucleotide polymorphisms (SNPs) associated with eosinophilia. As eosinophils play a key role in the pathogenesis of NP, we assessed if any of these SNPs contribute to genetic susceptibility of NP.We recruited 284 patients with NP in four participating hospitals in Belgium and 427 healthy controls, and genotyped 10 SNPs affecting eosinophilia (rs1420101 in IL1RL1, rs12619285 in IKZF2, rs4431128 in GATA2, rs4143832 in IL5, rs3184504 in SH2B3, rs2416257 in WDR36, rs2269426 in MHC, rs9494145 in MYB, rs748065 in GFRA2, and rs3939286 in IL33) using MALDI-TOF. A two-stage design was used while correcting for multiple testing.First stage analysis, involving 150 NP patients and 250 controls, identified rs3939286 nearby IL33 as a susceptibility factor for NP. Per at-risk A-allele, rs3939286 increased the risk for NP with an odds ratio (OR) of 1.60 (95% CI = 1.16-2.22; P = 0.0041). Second stage replication analysis in another 123 NP patients and 165 controls confirmed this association (OR = 1.43; CI = 1.00-2.06; P = 0.046). The combined analysis of both stages revealed an OR of 1.53 (CI = 1.21-1.96; P = 0.00041). Given the association of IL33 with NP, we also investigated rs1420101 in IL1RL1, which is the receptor for IL33. Although rs1420101 itself failed to associate with NP, a combined risk assessment of rs3939286 and rs1420101 further increased the risk for NP.We provide unprecedented genetic evidence suggesting a role for the IL33 pathway in the pathogenesis of NP.
The Treatment of Depression with a Single Daily Dose of Imipramine Pamoate
Authors: J. MENDELS, JOSEPH DIGIACOMO
Journal: American Journal of Psychiatry (1973)

A controlled comparison of the effects of 50 mg. of imipramine hydrochloride given three times daily and 150 mg. of imipramine pamoate in a single bedtime dose revealed no significant difference in either therapeutic effects or side effects in a group of 40 hospitalized depressed patients. The authors note the advantages of a single night dose of antidepressant medication.
BZ 55 in Diabetes
Authors: J. M. McKenzie, P. B. Marshall, J. M. Stowers, R. B. Hunter
Journal: BMJ (1956)

JOIRNALgiven in addition to their normal daily dose of insulin.It follows that, when insulin is a vital necessity in treatment, any attempt to replace it by BZ 55 is almost certain to result in a serious relapse.It is of interest that no response was obtained in a child of 9 with diabetes of five months' dura- tion who had never had insulin and whose urine contained no ketone bodies.On the negative side no constant relationship could be demonstrated between the response to BZ 55 and the age of the patient, the duration of the diabetes, or the dura- tion of insulin therapy.It seemed to be immaterial that in some of those who responded there had in the past been episodes of severe ketosis, associated with infection or other general conditions, the treatment of which required large doses of insulin.The factors in the representative series of 21 patients most consistently related to responsiveness to BZ 55 were the age of onset of diabetes, over 40 years in all cases, and absence of more than minimal ketonuria while on dietary control without insulin.The second series of 17 patients was therefore selected on these criteria.All the patients in this group were treated in the out-patient department and all showed some response to BZ 55.This would seem to indi- cate that the criteria used for selection were, in a limited sense, reasonably correct, and lend support to the findings of others who have carried out morc extensive therapeutic trials with BZ 55 (Symposium 1956a, 1956b).Our thanks are duc to Profcssor-G.Gray, the late Dr. H.Whittaker, Dr. J. A. Robertson, aild other members of the staff of the Diabetic Depar-tment who co-operated in this
Vintage Care
Authors: Richard Peters
Journal: JAMA (1997)

An elderly couple comes to the clinic for a routine visit and to receive their annual influenza vaccinations. The man has congestive heart failure with poor systolic function; his condition is stable on current medications. His wife has had 2 vertebral compression fractures but is otherwise healthy. The couple tells the physician seeing them that they want to give each other the authority to make medical decisions in the event one of them becomes incapacitated, and they ask for help infilling out a Durable Power of Attorney for Health Care form. The physicianprovides some basic advice, gives the couple 2 standard forms, and asks if they spend any time on the Internet. Learning that the couple regularly uses e-mail to communicate with relatives and increasingly explores the World Wide Web, the physician suggests several sites providing information about the health care proxy process. He also asks the couple to bring
Listeria Infection in Renal Transplant Recipients
Authors: Nelson M. Gantz
Journal: JAMA (1976)

the Editor.—  In his article (234:842, 1975), Isiadinso stated: To our knowledge, there have been no other reports, in the English literature, of Listeria infection complicating renal transplantation; however, this association has been well documented. 1-5 Listeriosis has also occurred sporadically in several other renal, as well as cardiac, transplantation centers.  The occurrence of six cases of listeriosis in a nine-month period in their renal transplantation unit should have been the emphasis of the report. This constitutes a cluster and raises the following questions: Did the organisms have the same serotype? What epidemiologic studies were undertaken to attempt to explain this outbreak?  We reported a cluster of eight cases of listeriosis in a 15-month period in immunosuppressed patients. Four of the patients were renal transplant recipients. 5 The occurrence of a cluster of cases caused by an opportunistic agent such as Listeria is the ideal setting to study the
On the Readability of Surgical Consent Forms
Authors: T. M. Grundner
Journal: New England Journal of Medicine (1980)

A great deal of attention has been paid to ensuring that surgical consent forms have valid content, but little effort has been made to ensure that the average patient can read and understand them. Five representative surgical consent forms were analyzed with two standardized readability tests. The readability of all five was approximately equivalent to that of material intended for upper-division undergraduates or graduate students. Four of the five forms were written at the level of a scientific journal, and the fifth at the level of a specialized academic magazine. I suggest that few consent forms currently in use could pass readability tests. The implication of these findings is that thousands of persons may be undergoing surgery each year on the basis of inadequate consent. The problem has a reasonably simple solution: analysis of all consent forms for readability, and rewriting of those found excessively difficult.