Acute Liver Failure in the United States
Authors: William M. Lee, Anne Larson, Robert Fontana, George Ostapowicz
Journal: Annals of Internal Medicine (2003)

Letters16 December 2003Acute Liver Failure in the United StatesWilliam M. Lee, MD, Anne Larson, MD, Robert Fontana, MD, and George Ostapowicz, MDWilliam M. Lee, MDFrom University of Texas Southwestern Medical Center, Dallas, TX 75390-9151; University of Washington, Seattle, WA 98195-6174; University of Michigan, Ann Arbor, MI 48109-0362; and Gold Coast Hospital, Southport, QLD 4215, Australia., Anne Larson, MDFrom University of Texas Southwestern Medical Center, Dallas, TX 75390-9151; University of Washington, Seattle, WA 98195-6174; University of Michigan, Ann Arbor, MI 48109-0362; and Gold Coast Hospital, Southport, QLD 4215, Australia., Robert Fontana, MDFrom University of Texas Southwestern Medical Center, Dallas, TX 75390-9151; University of Washington, Seattle, WA 98195-6174; University of Michigan, Ann Arbor, MI 48109-0362; and Gold Coast Hospital, Southport, QLD 4215, Australia., and George Ostapowicz, MDFrom University of Texas Southwestern Medical Center, Dallas, TX 75390-9151; University of Washington, Seattle, WA 98195-6174; University of Michigan, Ann Arbor, MI 48109-0362; and Gold Coast Hospital, Southport, QLD 4215, Australia.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-139-12-200312160-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Space did not permit us to expand on cases in which therapeutic doses of acetaminophen caused acute liver failure or to describe their particular features. The diagnosis for each case reported in our prospective trial was made by the site investigator, an experienced hepatologist, on the basis of standard criteria, including history of ingestion, plasma acetaminophen levels, and alanine aminotransferase levels exceeding 3500 U/L, as well as exclusion of other etiologies. History of ingestion may be inaccurate and difficult to obtain in patients whose mental status is altered, but ancillary information is usually available from family and from ...References1. Hawton K, Townsend E, Deeks J, Appleby L, Gunnell D, Bennewith O, . Effects of legislation restricting pack sizes of paracetamol and salicylate on self poisoning in the United Kingdom: before and after study. BMJ. 2001;322:1203-7. [PMID: 11358770] CrossrefMedlineGoogle Scholar2. Turvill JL, Burroughs AK, Moore KP. Change in occurrence of paracetamol overdose in UK after introduction of blister packs [Letter]. Lancet. 2000;355:2048-9. [PMID: 10905911] CrossrefMedlineGoogle Scholar3. Trey C, Davidson CS. The management of fulminant hepatic failure.. In: Popper H, Schaffner F, eds. Progress in Liver Diseases. New York: Grune & Stratton; 1970:282-98. Google Scholar Author, Article, and Disclosure InformationAffiliations: From University of Texas Southwestern Medical Center, Dallas, TX 75390-9151; University of Washington, Seattle, WA 98195-6174; University of Michigan, Ann Arbor, MI 48109-0362; and Gold Coast Hospital, Southport, QLD 4215, Australia. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoResults of a Prospective Study of Acute Liver Failure at 17 Tertiary Care Centers in the United States George Ostapowicz , Robert J. Fontana , Frank V. Schiødt , Anne Larson , Timothy J. Davern , Steven H.B. Han , Timothy M. McCashland , A. Obaid Shakil , J. Eileen Hay , Linda Hynan , Jeffrey S. Crippin , Andres T. Blei , Grace Samuel , Joan Reisch , William M. Lee , and Acute Liver Failure in the United States William D. Carey Acute Liver Failure in the United States Raquel Marie Schears Metrics Cited ByWhat Is Uncommon Can Be Critical: A Case of Quinolone-Induced Acute Liver FailureTargeted Analysis of 46 Bile Acids to Study the Effect of Acetaminophen in Rat by LC-MS/MSDiscovery of the relations between genetic polymorphism and adverse drug reactionsResistance to acetaminophen-induced hepatotoxicity in glutathione S-transferase Mu 1-null mice 16 December 2003Volume 139, Issue 12Page: 1045-1046KeywordsAcute liver failureBehaviorIngestionInternational normalized ratioLiverLiver diseasesPatientsProthrombin timeSedativesToxicity ePublished: 16 December 2003 Issue Published: 16 December 2003 CopyrightCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...