Chloroquine and Nonconvulsive Status Epilepticus
Authors: Paul Mulhauser
Journal: Annals of Internal Medicine (1995)

Letters1 July 1995Chloroquine and Nonconvulsive Status EpilepticusPaul Mulhauser, MD, Yves Allemann, MD, and Claude Regamey, MDPaul Mulhauser, MDHopital Cantonal; 1708 Fribourg; Switzerland, Yves Allemann, MDHopital Cantonal; 1708 Fribourg; Switzerland, and Claude Regamey, MDHopital Cantonal; 1708 Fribourg; SwitzerlandAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-123-1-199507010-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We describe an otherwise healthy 68-year-old woman who was receiving prophylactic antimalarial doses of chloroquine (100 mg daily) while traveling in India. She had no history of epilepsy or alcohol abuse and was receiving no other medication. Twelve days after starting chloroquine, she suddenly had difficulties in finding her words and began to stammer. She exhibited erratic behavior, continuously opening, rummaging in, and closing her handbag for no obvious reason. These symptoms fluctuated, lasting from minutes to hours.One day after the onset of the symptoms, the patient was admitted to our hospital. At admission, the patient ...References1. Danis M, Diquet B, Turk P, Brousse G, Bretagne S, Dufourg P. Pharmacocinetique de la chloroquine a doses prophylactiques chez 10 volontaires sains. Bull Soc Path Exo. 1985; 78:953-8. Google Scholar2. Treiman DM, Delgado-Escueta AV. Complex partial status epilepticus. Adv Neurol. 1983; 34:69-81. Google Scholar3. Cascino G. Nonconvulsive status epilepticus in adults and children. Epilepsia. 1993; 34(Suppl 1):21-8. Google Scholar4. Martindale W. The Extra Pharmacopoeia. 30th ed. London: Pharmaceutical Pr; 1993:396-400. Google Scholar5. Good M, Shader R. Lethality and behavioral side effects of chloroquine. J Clin Psychopharmacol. 1982; 2:40-7. Google Scholar Author, Article, and Disclosure InformationAuthors: Paul Mulhauser, MD; Yves Allemann, MD; Claude Regamey, MDAffiliations: Hopital Cantonal; 1708 Fribourg; Switzerland PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySafety of Short-Term Treatments with Oral Chloroquine and Hydroxychloroquine in Patients with and without COVID-19: A Systematic ReviewNeurological Effects of COVID-19 in ChildrenChallenges and management of neurological and psychiatric manifestations in SARS-CoV-2 (COVID-19) patientsUnusual Causes of Status EpilepticusPossible involvement of nitrergic and opioidergic systems in the modulatory effect of acute chloroquine treatment on pentylenetetrazol induced convulsions in miceDrug-induced status epilepticusDe novo generalised non-convulsive status epilepticus triggered by piperacillin/tazobactamMalaria Prophylaxis: A Comprehensive ReviewReview article: Convulsive and non-convulsive status epilepticus: An emergency medicine perspectivePSYCHIATRIC MANIFESTATIONS OF SYSTEMIC ILLNESSChloroquine 1 July 1995Volume 123, Issue 1Page: 76-77KeywordsAnticonvulsantsAntimalarialsCerebrospinal fluidChloroquineElectrocardiographyElectroencephalographyEpilepsyHerpes simplexStatus epilepticusSyphilis ePublished: 15 August 2000 Issue Published: 1 July 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...