Errors in Meta-analysis Regarding the 3CPO Trial
Authors: Steve W. Goodacre, Alasdair Gray, David Newby
Journal: Annals of Internal Medicine (2010)

Letters17 August 2010Errors in Meta-analysis Regarding the 3CPO TrialSteve W. Goodacre, DipIMC, MSc, PhD, Alasdair Gray, MD, and David Newby, MD, PhD, DScSteve W. Goodacre, DipIMC, MSc, PhDFrom University of Sheffield, Sheffield S10 2TN, United Kingdom; Royal Infirmary of Edinburgh, Edinburgh EH16 4SA, United Kingdom; and University of Edinburgh, Edinburgh EH8 9YL, United Kingdom.Search for more papers by this author, Alasdair Gray, MDFrom University of Sheffield, Sheffield S10 2TN, United Kingdom; Royal Infirmary of Edinburgh, Edinburgh EH16 4SA, United Kingdom; and University of Edinburgh, Edinburgh EH8 9YL, United Kingdom.Search for more papers by this author, and David Newby, MD, PhD, DScFrom University of Sheffield, Sheffield S10 2TN, United Kingdom; Royal Infirmary of Edinburgh, Edinburgh EH16 4SA, United Kingdom; and University of Edinburgh, Edinburgh EH8 9YL, United Kingdom.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-153-4-201008170-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:As co-investigators on the 3CPO (Three Interventions in Cardiogenic Pulmonary Oedema) trial (1), we were interested in the meta-analysis of noninvasive ventilation by Weng and colleagues (2). We found that the authors of the meta-analysis misrepresented 2 quality criteria and the prevalence of myocardial infarction in relation to the 3CPO trial. First, the authors incorrectly stated that the 3CPO trial did not have allocation concealment. Although 3CPO was an open trial, participants were allocated to a treatment group by a telephone randomization system after they had been irreversibly entered into the trial. Second, the withdrawal rate for ...References1. Gray A, Goodacre S, Newby DE, Masson M, Sampson F, Nicholl J; 3CPO Trialists. Noninvasive ventilation in acute cardiogenic pulmonary edema. N Engl J Med. 2008;359:142-51. [PMID: 18614781] CrossrefMedlineGoogle Scholar2. Weng CL, Zhao YT, Liu QH, Fu CJ, Sun F, Ma YL, et al. Meta-analysis: Noninvasive ventilation in acute cardiogenic pulmonary edema. Ann Intern Med. 2010;152:590-600. [PMID: 20439577] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From University of Sheffield, Sheffield S10 2TN, United Kingdom; Royal Infirmary of Edinburgh, Edinburgh EH16 4SA, United Kingdom; and University of Edinburgh, Edinburgh EH8 9YL, United Kingdom.Disclosures: All authors are co-investigators on the 3CPO trial. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoMeta-analysis: Noninvasive Ventilation in Acute Cardiogenic Pulmonary Edema Cui-Lian Weng , Yun-Tao Zhao , Qing-Hua Liu , Chang-Jun Fu , Feng Sun , Yan-Liang Ma , Yan-Wen Chen , and Quan-Ying He Errors in Meta-analysis Regarding 3CPO Trial Yun-Tao Zhao Metrics Cited byNon-invasive Ventilatory Support in the ElderlyStatistical controversies in clinical research: overlap and errors in the meta-analyses of microRNA genetic association studies in cancers 17 August 2010Volume 153, Issue 4Page: 277-278KeywordsEdemaHealth care quality assessmentInfarctionIschemiaMyocardial infarctionNoninvasive ventilationOxygenPatientsPhysiotherapy ePublished: 17 August 2010 Issue Published: 17 August 2010 Copyright & PermissionsCopyright © 2010 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...