tbuckley/cabot-search huggingface dataset:
The Patient-Doctor Relationship
Authors: LEO I. STEMP
Journal: Annals of Internal Medicine (1988)

Letters and Corrections1 April 1988The Patient-Doctor RelationshipLEO I. STEMP, M.D.LEO I. STEMP, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-108-4-635_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I read with interest Suchman and Matthews's article (1) on the patient-doctor relationship. During my years in medical school, I had the privilege of working with a professor of plastic surgery, Robert Goldwyn, from whom I learned that more important in medicine than anything else—even, perhaps, than an objective cure or other result—is the patient's experience of his or her medical encounter. Possibly the single most important determinant is the quality of the patient's relationship with his or her physician; this is a major determinant of the patient's subjective perception of the results of treatment (2).I...References1. SUCHMANMATTHEWS AD. What makes the patient-doctor relationship therapeutic? Exploring the connexional dimension of medical care. Ann Intern Med. 1988;108:125-30. LinkGoogle Scholar2. GOLDWYN R. The Unfavorable Result in Plastic Surgery. Boston: Little Brown; 1972. Google Scholar1. SUCHMANMATTHEWS AD. What makes the patient-doctor relationship therapeutic? Exploring the connexional dimension of medical care. Ann Intern Med. 1988;108:125-30. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Stanford University Medical Center Stanford, CA 94305 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1988Volume 108, Issue 4Page: 635-636KeywordsPerceptionPlastic surgery Issue Published: 1 April 1988 PDF downloadLoading ...
Chemotherapy in Gonorrhoea
Authors: F. J. T. Bowie
Journal: BMJ (1938)

One of the most intriguing characteristics of medical research work lies in the possibility that overnight a remedy of unbelievable therapeutic potency may be pro- duced and that the millennium of gonorrhoea control may be close at hand."Thus writes Parran (1937) in respect of what may eme-rge from sulphanilamide in the control of gonorrhoea.The introduction of 2-(p-aminobenzenesulphonamido)pyridine, M. and B. 693, is an event which bids fair to produce a notable advance in the attack on the gono- coccus.Reference has already been made to some of its results in experimental work in mice by Whitby (1938), in pneumonia by Telling and Oliver (1938) and Evans and Gaisford (1938a, 1938b), and in the treatment of gonorrhoea by Lloyd, Erskine, and Johnson (1938).The following report, essentially of a preliminary character, supports the findings, published at a similar stage of experimental treatment, by Lloyd et al., and is of con- siderable interest in its clinical bearings.
A Case of Enteric Fever, Complicated by Perforation, Peritonitis, and Relapse, and Followed by Perityphlitic Abscess: Recovery
Authors: E. B. Steel
Journal: BMJ (1897)

fmimiL Jou4aL 13 vas bearing upon the perineum evidence of the nature of the -difficulty became manifest by great retraction between the pains, which were becoming shorter and less effectual, though not from exhaustion, as she continued cheerful with a good pulse.Pelvic examination showed no cause, there being ample space with yielding soft parts, and the nature of the presentation was further confirmed by feeling, with ease, the pinna of the left ear.Abdominal examination showed a single gestation, with the placenta at the fundus, where the rotundity became much less defined during uterine action.Though during the labour a firm binder had been applied
Government axes a further 11 health quangos
Authors: J. Wise
Journal: BMJ (2010)

The UK government has confirmed that 15 health related arm’s length bodies, including four previously announced in July, are to be abolished and that a further 19 will be subsumed into other organisations and government departments.

Most of the health advisory committees, some of whose remit covers the whole of the United Kingdom, will simply be reconstituted as committees of experts in the Department of Health of England or the planned new Public Health Service. These include the Joint Committee on Vaccinations and Immunisation, the Human Genetics Commission, and advisory committees on borderline substances, dangerous pathogens, AIDS, antimicrobial resistance, hepatitis, nutrition, and aspects of radiation and the environment.

Other advisory committees will now come under the umbrella of the UK Medicines and Healthcare Products Regulatory Agency. These include committees on herbal medicines, homoeopathic products, the advertising of drugs, and the classification of borderline products.

Nine of the changes had already been announced as part of the health department’s review of arm’s length bodies in July ( BMJ 2010;341:c4074, doi:10.1136/bmj.c4074). Despite protests these will go ahead and include the abolition of the Human Fertilisation and Embryology Authority and the Human Tissue Authority, which will also see their functions transferred to other regulators. The Health Protection Agency is also …
Government row flares up over vitamin B-6
Authors: J. Warden
Journal: BMJ (1998)

Restrictions on vitamin B-6 proposed by the British government on the advice of its own experts have been repudiated by a Commons select committee on the grounds that the advice was scientifically unjustified and palpably wrong

The government is now in the position of either having to rescind the proposed controls or reject the select committee's views and incur the public antagonism it has exposed. Some three million people in Britain take vitamin B-6 as a dietary supplement for relieving stress or premenstrual syndrome.

Many thousands of …
Survival in Microsatellite-Unstable Colorectal Cancer
Authors: Toshiaki Watanabe, Yoko Yamamoto, Hideki Yamada, Tamuro Hayama, Yoshiko Aoyagi, Keisuke Nakamura, Hajime Shibuya, Takashi Kobunai
Journal: Clinical Cancer Research (2008)

To the Editors: We read with interest Malesci et al's article in the recent issue of Clinical Cancer Research ([1][1]). They showed that microsatellite instability (MSI) was a significant stage-dependent predictor of survival in patients with colorectal cancer. Malesci et al. introduced our previous
A critical evaluation of the MefarTM dosimeter
Authors: R.J. Ward, P. Liakakos, R.F. Leonard, D.W. Reid, D.P. Johns, E.H. Walters
Journal: European Respiratory Journal (1999)

Multicentre studies of airway responsiveness (AR) are increasingly important tools in asthma epidemiology. Because comparisons of AR are made between centres it is essential that measurement techniques are accurate and standard. This study investigated the Mefar dosimeter which is currently used in the 35 centre European Community Respiratory Health Survey (ECRHS) with the next phase currently being planned. Significant differences were found in driving pressures and aerosol outputs between the three Mefar dosimeters in the laboratory. A linear relationship was also found between driving pressure and aerosol output (R2=0.96). These differences are important as they may lead to variations between centres of < or =35% in the drug dose delivered in AR measurement, which could potentially diminish the power of individual study centres to accurately detect national differences in AR. Dosimeter driving pressure and nebulizer output should be standardized in future studies of airway responsiveness. With relatively simple quality control measures in place it is believed that the Mefar dosimeter can produce reliable between-centre longitudinal data with an increase in the accuracy of these important studies.
Loss of integrin linked kinase from mouse hepatocytesin vitro andin vivo results in apoptosis and hepatitis
Authors: Vasiliki Gkretsi, Wendy M. Mars, William C. Bowen, Lindsay Barua, Yu Yang, Lida Guo, René St.‐Arnaud, Shoukat Dedhar, Chuanyue Wu, George K. Michalopoulos
Journal: Hepatology (2007)

Extracellular matrix (ECM) is fundamental for the survival of cells within a tissue. Loss of contact with the surrounding ECM often causes altered cell differentiation or cell death. Hepatocytes cultured without matrix lose patterns of hepatocyte-specific gene expression and characteristic cellular micro-architecture. However, differentiation is restored after the addition of hydrated matrix preparations to dedifferentiated hepatocytes. Integrin-linked kinase (ILK) is an important component of cell–ECM adhesions transmitting integrin signaling to the interior of the cell. ILK has been implicated in many fundamental cellular processes such as differentiation, proliferation, and survival. In this study, we investigated the role of ILK in mouse hepatocytes in vitro as well as in vivo. Depletion of ILK from primary mouse hepatocytes resulted in enhanced apoptosis. This was accompanied by increased caspase 3 activity and a significant decrease in expression of PINCH and α-parvin, which, along with ILK, form a stable well-characterized ternary complex at cell–ECM adhesions. The induction of apoptosis caused by ILK depletion could be substantially reversed by simultaneous overexpression of ILK, indicating that apoptosis is indeed a consequence of ILK removal. These results were further corroborated via in vivo data showing that adenoviral delivery of Cre-recombinase in ILK-floxed animals by tail vein injection resulted in acute hepatitis, with a variety of pathological findings including inflammation, fatty change, and apoptosis, abnormal mitoses, hydropic degeneration, and necrosis. Conclusion: Our results demonstrate the importance of ILK and integrin signaling for the survival of hepatocytes and the maintenance of normal liver function. (HEPATOLOGY 2007.)
Unilateral Adrenal Metastasis From Non–Small-Cell Lung Cancer Demonstrating Very High FDG Uptake With a Standardized Uptake Value in Excess of Sixty
Authors: Mohamed Shawgi, Jackie James, Mary Prescott, Lorna McWilliam
Journal: Clinical Nuclear Medicine (2012)

We report the case of a 52-year-old man who presented with a 2-week history of dyspnea and wheeze. CT scan of the chest showed a large soft-tissue lesion in the right main bronchus extending into the trachea. Pathologic examination of endoscopic tracheal biopsies showed features consistent with a non–small-cell lung carcinoma. 18F-FDG PET/CT showed very high uptake of FDG in the bronchial tumor (high standardized uptake values: 25.1) and unexpected very intense uptake in the left adrenal gland (high standardized uptake values: 62.5). Laparoscopic adrenalectomy was performed, and subsequent histopathological examination confirmed metastatic non–small-cell carcinoma in the adrenal gland. Although adrenal malignancies are generally metabolically active, such high uptake of FDG within a metastatic lesion has not been reported previously.
Abstract 2236: The Biospecimen Methodological Study (BMS): Identifying best practices for tissue preservation and maintenance of RNA integrity
Authors: Abhi Rao, Latarsha Carithers, Helen Moore
Journal: Cancer Research (2014)

Abstract Researchers may use a number of traditional methods for human tissue preservation and stabilization such as liquid nitrogen (LN2) or dry ice, and yet the effectiveness of newer methods remains unclear. The National Cancer Institute's Biorepositories and Biospecimen Research Branch (BBRB; formerly known as OBBR) conducted a study to better understand such tissue preservation methods to inform BBRB's biospecimen collection efforts for the NIH Genotype-Tissue Expression (GTEx) program. The Biospecimen Methodological Study (BMS) was developed to provide an evidence-based structure to support future tissue collection and data analysis methods by comparing features of three different preservation methods: PAXgene Tissue (Qiagen); LN2; and dry ice. In preliminary studies, use of PAXgene Tissue has proven highly successful in preservation and maintenance of RNA quality. Another critical aspect of the BMS was to determine the degree to which the time between cardiac cessation and tissue preservation alters RNA integrity; such changes in molecular integrity could result in changes in molecular profiles upon gene expression analysis. The results of this study will provide valuable information about tissue processing parameters by identifying artifacts associated with different preservation methods and timing post cardiac cessation. Identifying and utilizing superior biospecimen preservation methods for RNA analysis will help identify patient-specific changes in gene expression and ultimately contribute to the development of targeted molecular medicine. Citation Format: Abhi Rao, Latarsha Carithers, Helen Moore. The Biospecimen Methodological Study (BMS): Identifying best practices for tissue preservation and maintenance of RNA integrity. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2236. doi:10.1158/1538-7445.AM2014-2236
The spin on sperm
Authors: K. Abbasi
Journal: BMJ (1997)

Kamran Abbasi reports on the launch of a controversial technique to select a baby's sex which received a large amount of positive media coverage. 

RightBaby, an Anglo-French company marketing a new gender selection technique, has enjoyed worldwide media coverage, much of it uncritical. As a result, a week after its launch in Britain the Oxfordshire based company had received over 1300 inquiries. Alas, this seems to be another triumph for the purveyors of spin, as the company could not provide full details to support its claims and has not published in a peer reviewed journal.

Even before the official launch, the Daily Mail gave front page coverage to the story: “Would you pay £199 to choose your baby's sex?” Inside, on the health page, Anastasia Stephens informed her readers that: “A controversial test that tells women on …
A Test for Transplantability of Animal Hearts
Authors: Julia T. Apter
Journal: JAMA (1968)

Current studies in transplantation of canine and human hearts have made it advisable to develop a method for detecting postmortem changes in hearts quickly and accurately. We use reversibility of the thermal responses of the viscoelastic properties of cardiac muscle to determine whether or not an excised heart is in a steady state. The test samples are taken from the tip of the atrial appendage and a report of cardiac muscle status may be made within 15 minutes, or before chemical signs of rigor mortis appear in the sampled organ. <h3>Methods Used in Designing the Test.—</h3> Rectangular segments of ventricles, atria, and atrial appendages were excised from in situ hearts of 17 dogs, 23 cats, and 13 rabbits anesthetized with 30 mg/kg of body weight of sodium pentobarbital. With this technique, a slit in the segment is slipped over two hooks to support it horizontally in a bath of known
ON PRESERVING EMBRYOLOGICAL MATERIAL.
Authors: ADOLF MEYER
Journal: JAMA (1894)

Preparing some work on the development and the anatomy of the brain, I beg to bring the following appeal for cooperation before the members of the profession: It is necessary to start the work on as broad a basis as possible, and for this reason it can not be done without the active cooperation of the practitioners. It is my desire to show that a large city like Chicago can, notwithstanding its short existence, make up for a long period of preparation with its youthful energy and take at once, as it did ill many respects through the Fair, a place in the foremost ranks of scientific centers. This energetic progress shows itself in every line of scientific research, and I feel confident that an appeal for help in promoting our knowledge of the nervous centers will not be in vain. Embryological material becomes of value only if a sufficient
Correlation between Long-acting Thyroid Stimulator Protector Level and Thyroid 131I Uptake in Thyrotoxicosis
Authors: D. D. Adams, T. H. Kennedy, R. D. H. Stewart
Journal: BMJ (1974)

Out of 50 consecutive untreated patients with diffuse toxic goitre 15 showed long-acting thyroid stimulator (LATS), 30 showed LATS protector only, and five showed neither. LATS protector was present in all the patients with LATS. Infiltrative ophthalmopathy was less common in patients with LATS protector only (40%) than in patients with LATS also (67%), but the difference was not significant. There was a correlation between LATS protector level and thyroid <sup>131</sup>I uptake rate factor (k<sub>1</sub>), the coefficient (r) being 0·68 (P &lt; 0·001). LATS level showed no such correlation. The results support the hypothesis that LATS protector is a pathogenic thyroid stimulator in patients with diffuse toxic goitre.
Lesions of the Feet in Diabetes
Authors: R. A. Goodbody
Journal: BMJ (1957)

Through a discussion of a range of research drawn from the humanities and social sciences, and with a particular emphasis on work that tackles questions about the discourse of the life sciences, this paper considers some of the difficulties with research that aims to offer a critical analysis of immunology and its relationship to culture. It considers in particular arguments made on behalf of a biopolitical reading of the life sciences and, by examining the uncertain shift between discursive analysis and philosophical claim, it seeks to address some of the underlying assumptions made about the relations between different kinds of knowledge practice in the interplay between life science, philosophy and culture. Drawing on the work of Belgian philosopher of science Isabelle Stengers to consider the ways in which critical and philosophical appraisals of immunology adopt a characteristically modern stance in the way that they address the life sciences, it further seeks to characterise some of the limits that such forms of critique display.
USING O-15 TO STUDY OXYGEN CARRYING CAPACITIES IN HEMOGLOBIN-BASED BLOOD SUBSTITUTES
Authors: L. Lemen, W. T. Phillips, R. Klippcr, A. S Rudolph, R. Cliff, M. E. Emch, P. A. Jerabek, C. C. Martin, P. T. Fox
Journal: Clinical Nuclear Medicine (1995)

Lemen, L.; Phillips, W. T.; Klippcr, R.; Rudolph, A. S; Cliff, R.; Emch, M. E.; Jerabek, P. A.; Martin, C. C.; Fox, P. T. Author Information
Book Review Treatment and Management of Cancer in the Elderly (Basic and Clinical Oncology. Vol. 34.) Edited by Hyman B. Muss, Carrie P. Hunter, and Karen A. Johnson. 622 pp., illustrated. New York, Informa Healthcare/Taylor &amp; Francis, 2006. $199.95. 978-0-8493-4035-2
Authors: Jeffrey Crawford
Journal: New England Journal of Medicine (2007)
The Strange Case of the Broad Street Pump: John Snow and the Mystery of Cholera
Authors: Warren Winkelstein
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE PASSING OF PLASTER.
Authors: EDWARD A. TRACY
Journal: JAMA (1897)

At the Atlanta meeting of theAssociation, in a discussion before this Section, Prof. Thomas H. Manley of New York made the statement that "plaster-of-paris, as a routine treatment for fractures, should be discarded." The advanced ground taken by that able surgeon is certainly welcomed by the writer, who believes that plaster-of-paris, as a routine means of surgical fixation is doomed, and that its wane will be rapid because of its inherent defects and of the advantages possessed by its rival, wood-fiber splinting. It will hardly be gainsaid that at present, particularly in the hospitals, plaster-of-paris holds sway as the routine treatment for most fracture cases. Routine, unless perfection has been reached, is baneful to progress in all fields of human endeavor. It can be so in surgery. Happily, however, in this field of activity, there are willing minds and hands to welcome whatever tends toward improvement in their art,
Cognitive Behavioral Therapy for Treatment of Chronic Primary Insomnia
Authors: Jack D. Edinger, William K. Wohlgemuth, Rodney A. Radtke, Gail R. Marsh, Ruth E. Quillian
Journal: JAMA (2001)

ContextUse of nonpharmacological behavioral therapy has been suggested for treatment of chronic primary insomnia, but well-blinded, placebo-controlled trials demonstrating effective behavioral therapy for sleep-maintenance insomnia are lacking.ObjectiveTo test the efficacy of a hybrid cognitive behavioral therapy (CBT) compared with both a first-generation behavioral treatment and a placebo therapy for treating primary sleep-maintenance insomnia.Design and SettingRandomized, double-blind, placebo-controlled clinical trial conducted at a single academic medical center, with recruitment from January 1995 to July 1997.PatientsSeventy-five adults (n = 35 women; mean age, 55.3 years) with chronic primary sleep-maintenance insomnia (mean duration of symptoms, 13.6 years).InterventionsPatients were randomly assigned to receive CBT (sleep education, stimulus control, and time-in-bed restrictions; n = 25), progressive muscle relaxation training (RT; n = 25), or a quasi-desensitization (placebo) treatment (n = 25). Outpatient treatment lasted 6 weeks, with follow-up conducted at 6 months.Main Outcome MeasuresObjective (polysomnography) and subjective (sleep log) measures of total sleep time, middle and terminal wake time after sleep onset (WASO), and sleep efficiency; questionnaire measures of global insomnia symptoms, sleep-related self-efficacy, and mood.ResultsCognitive behavioral therapy produced larger improvements across the majority of outcome measures than did RT or placebo treatment. For example, sleep logs showed that CBT-treated patients achieved an average 54% reduction in their WASO whereas RT-treated and placebo-treated patients, respectively, achieved only 16% and 12% reductions in this measure. Recipients of CBT also showed a greater normalization of sleep and subjective symptoms than did the other groups with an average sleep time of more than 6 hours, middle WASO of 26.6 minutes, and sleep efficiency of 85.1%. In contrast, RT-treated patients continued to report a middle WASO of 43.3 minutes and sleep efficiency of 78.8%.ConclusionsOur results suggest that CBT represents a viable intervention for primary sleep-maintenance insomnia. This treatment leads to clinically significant sleep improvements within 6 weeks and these improvements appear to endure through 6 months of follow-up.