The Effects of Spinal Osteomyelitis on Porphyrin-Precursor Excretion, and the Presence of Gout in a Patient with Latent Acute Intermittent Porphyria
Authors: FREDERICK H. WELLAND
Journal: Annals of Internal Medicine (1963)

Case Studies1 October 1963The Effects of Spinal Osteomyelitis on Porphyrin-Precursor Excretion, and the Presence of Gout in a Patient with Latent Acute Intermittent PorphyriaFREDERICK H. WELLAND, M.D., DONALD P. TSCHUDY, M.D.FREDERICK H. WELLAND, M.D.Search for more papers by this author, DONALD P. TSCHUDY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-59-4-547 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThis report describes a patient in whom symptoms of an inflammatory spinal lesion mimicked an attack of previously diagnosed but latent acute intermittent porphyria (AIP). The osteomyelitic process and the stress of surgical procedures affected the quantity of δ-aminolevulinic acid and porphobilinogen excreted by the patient. In addition, the patient has gout, a second "inborn error of metabolism." This is of interest since low serum uric acid levels have been reported in patients with AIP (1) and decreased urate production has been observed in experimental porphyria (2).CASE REPORTL. W. C., (045159) a 56-year-old white male machinist, was admitted...References1. TAXAY E: Serum uric acid in porphyria. Lancet 2: 936, 1961. CrossrefGoogle Scholar2. TALMANLABBEALDRICHSEARS ERRD: Porphyrin metabolism. V. The metabolism of purines in experimental porphyria. Arch. Biochem. 80: 446, 1959. CrossrefGoogle Scholar3. WATSONSCHWARTZ CS: A simple test for urinary porphobilinogen. Proc. Soc. Exp. Biol. Med. 47: 393, 1941. CrossrefGoogle Scholar4. SCHWARTZBERGBOSSENMAIERDINSMORE SMIH: Determination of porphyrins in biological materials. Meth. Biochem. Anal. 8: 221, 1960. Google Scholar5. HELLMANTSCHUDYBARTTER EDF: Abnormal electrolyte and water metabolism in acute intermittent porphyria: the transient inappropriate secretion of antidiuretic hormone. Amer. J. Med. 32: 734, 1962. 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Author, Article, and Disclosure InformationAffiliations: Bethesda, MarylandFrom the Metabolism Service, National Cancer Institute, National Institutes of Health, Bethesda 14, Maryland.Requests for reprints should be addressed to Donald P. Tschudy, M.D., The Metabolism Service, National Cancer Institute, National Institutes of Health, Bethesda 14, Maryland. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByHEREDITARY HEPATIC PORPHYRIAS 1 October 1963Volume 59, Issue 4Page: 547-553KeywordsConstipationExcretionGoutInborn errors of metabolismLesionsOsteomyelitisPorphyriaUric acid Issue Published: 1 October 1963 PDF DownloadLoading ...