tbuckley/cabot-search huggingface dataset:
Prospective comparison treatment of 595-nm pulsed-dye lasers for virgin port-wine stain
Authors: W. Yu, G. Ma, Y. Qiu, H. Chen, Y. Jin, X. Yang, L. Chang, T. Wang, X. Hu, W. Li, X. Lin
Journal: British Journal of Dermatology (2014)

Background Vbeam® and Cynergy® are 595-nm pulsed-dye laser (PDL) equipment options, both extensively used in the clinical treatment of port-wine stains (PWS). However, there has been no study conducted of the differences in PWS therapeutic outcomes across both devices. Objectives To compare the efficacy and safety of Vbeam and Cynergy equipment in the treatment of PWS. Methods Twenty-two patients with PWS were included in this study and were treated with both Vbeam and Cynergy. Patients underwent three treatment sessions. Treatment parameters used were as follows: (i) Cynergy®, Cynosure Corp., 595-nm wavelength, radiant exposure of 11 J cm−2, 2-ms pulse duration, 7-mm spot size, cold-air cooling system of level 3. (ii) Vbeam®, Candela Corp., 595-nm wavelength, radiant exposure of 11 J cm−2, 1·5-ms pulse duration, 7-mm spot size, cryogen spray cooling (30 ms of cooling with a 20-ms delay). Clinical efficacy outcomes were evaluated by chromameter and visual assessment 2 months post-treatment. Results All patients were treated by both Vbeam and Cynergy on adjacent sites. Chromameter evaluation showed that the average blanching rate was 21·24% for Cynergy sites and 36·42% for Vbeam sites. This difference was statistically significant (P = 0·05), which suggests that PWS respond better to Vbeam than to Cynergy at the settings used in this study. No patients developed scarring or permanent pigmentation change. Conclusions Compared with Cynergy, Vbeam may be more effective in the treatment of PWS. Despite using supposedly equivalent fluences in 595-nm PDLs, equivalent clinical results cannot be guaranteed.
Expanding the Black Box — Depression, Antidepressants, and the Risk of Suicide
Authors: Richard A. Friedman, Andrew C. Leon
Journal: New England Journal of Medicine (2007)

On May 2, the FDA ordered that all antidepressant medications carry an expanded black-box warning incorporating information about an increased risk of suicidal symptoms in young adults 18 to 24 years of age. Dr. Richard Friedman and Andrew Leon write that this new label has the potential to confuse both patients and physicians. Dr. Andrew Leon discusses the expansion of the black-box warning for antidepressants to cover the risk of suicidality among young adults, the suicidality risk associated with depression, and the data available for assessing these risks. Dr. Leon is a professor of biostatistics in psychiatry and a professor of public health at Weill Cornell Medical College, New York, and a member of the FDA's Psychopharmacologic Drugs Advisory Committee.
College admits that 10 vascular surgeons need to have their mortality rates reviewed
Authors: N. Hawkes
Journal: BMJ (2013)

Ten vascular surgeons have been asked to check their performance data after analysis showed their mortality rates were higher than expected.

The 10 were among around 450 surgeons whose mortality rates for operations such as repair of aortic aneurysms went public at the beginning of July.1 At the time the Royal College of Surgeons said that all surgeons were operating “within the range expected.” But the BBC subsequently reported that the results of 10 surgeons were sufficiently poor to raise an alert.2

The …
The changing incidence of primary central nervous system lymphoma is driven primarily by the changing incidence in young and middle‐aged men and differs from time trends in systemic diffuse large B‐cell non‐Hodgkin's lymphoma
Authors: Brian Patrick O'Neill, Paul A. Decker, Christina Tieu, James R. Cerhan
Journal: American Journal of Hematology (2013)

There has been an overall decline in the United States incidence of Primary CNS Lymphoma (PCNSL) from 1998 to 2008. This study's intent was to characterize the cohorts contributing to it. First, calculated the PCNSL incidence rates from nine Surveillance, Epidemiology, and End Results (SEER) registries for time period 1973 to 2008. Second, examined the time trends overall and by age and gender. Third, used 1992-2008 SEER data from the same registries to obtain overall trends for diffuse large B-cell lymphoma (DLBCL). Last, rates were age-adjusted to the 2000 US standard population and reported per 100,000 person-years. Rates continued to increase in women at all ages and men aged 65 and older. In men aged 20-39 and 40-64 years incidence rates peaked in 1995 and then declined dramatically, stabilizing after 1998. The trends in the incidence of PCNSL over this time frame were significantly different from DLBCL for ages 20-39 (P < 0.001) and 40-64 (P < 0.001) years but were not different for the 65 years and older age group (P = 0.99). The overall PCNSL incidence rate declined since 1995 and was driven primarily by the changing incidence in young and middle-aged men. The rate has continued to increase in men aged 65 years and older and in women. The trends in incidence in the younger age groups over this time period did not parallel those observed for DLBCL.
Pubertal Growth, Sexual Maturation, and Final Height in Children With IDDM: Effects of age at onset and metabolic control
Authors: Mariacarolina Salerno, Alessandro Argenziano, Salvatore Di Maio, Nicoletta Gasparini, Stefania Formicola, Glanpaolo De Filippo, Alfred Tenore
Journal: Diabetes Care (1997)

OBJECTIVE To evaluate growth and pubertal development in children with IDDM and the influence of the age at onset of IDDM and the degree of metabolic control on final height. RESEARCH DESIGN AND METHODS We conducted a retrospective evaluation of 62 subjects followed longitudinally both clinically and metabolically from the onset of IDDM until final height was reached. RESULTS Height at diagnosis was within the normal percentiles in boys (0.5 ± 1.0 standard deviation score [SDS]) and girls (0.4 ± 1.0 SDS), but above the genetic target height (−1.0 ± 0.9 SDS in boys and −1.1 ± 0.6 SDS in girls; P = 0.0001 for both comparisons). Although a lesser height gain was observed during the ensuing years, the final height reached by boys (−0.4 ± 1.1 SDS) and girls (−0.4 ± 0.9 SDS) was higher than the genetic target height. Blunted total pubertal growth was observed both in boys (24.5 ± 3.6 cm) and girls (20.1 ± 4.2 cm). The decrease in height gain was independent of the duration of IDDM, the degree of metabolic control, or the insulin requirement. The greater the height at diagnosis, with respect to the genetic target height, the lesser was the subsequent height gain to reach final adult height (r = 0.34, p &amp;lt; 0.01). BMI increased with age as normally occurs in healthy children, independent of the duration of disease and the degree of metabolic control. Pubertal development began and progressed normally both in boys and girls. In boys, a testicular volume of 4 ml was reached at a mean age of 12.1 ± 0.9 years. In girls, breast enlargement occurred at a mean age of 10.4 ± 1.2 years and the mean age of menarche was 12.8 ± 1.4 years. Pubertal development and progression occurred independent of the age at onset of IDDM, the glycemic control, or the insulin requirement during the pubertal period. CONCLUSIONS Children with IDDM have normal onset of puberty and normal sexual maturation. Even though final height falls within the normal percentiles, the diminished height gain after diagnosis requires further investigation.
Epidemiology of basal cell carcinoma in Lithuania, 1996-2010
Authors: R. Jurciukonyte, I. Vincerzevskiene, A. Krilaviciute, M. Bylaite, G. Smailyte
Journal: British Journal of Dermatology (2013)

Background Nonmelanoma skin cancer is the most common cancer among the white population. Objectives To describe the epidemiology of basal cell carcinoma (BCC) in Lithuania by analysing population-based incidence, with special emphasis on sex- and subsite-specific changes over time. Methods Data from the Lithuanian Cancer Registry for the period 1996–2010 were used to analyse trends in the incidence rates for BCC. Only the first case of BCC per patient was included in this analysis. Age-standardized rates were calculated for both sexes. Standardization was performed using the direct method (European standard population). Results Since 1996, overall BCC incidence rates have increased from 27·4 to 46·0 cases per 100 000 in Lithuania. In 1996, the incidence of BCC was higher among women than men (28·2 vs. 27·6 per 100 000, respectively). Incidence of BCC during the study period increased faster among men than among women (by 3·3% and 2·6% per year, respectively), while the incidence among both sexes in 2010 became almost equal – 46·4 among men and 47·4 among women per 100 000. The head and neck was the most common site of BCCs for both sexes (31·0 and 32·9 per 100 000 among men and women, respectively). Conclusions The incidence of BCC in Lithuania is lower than that reported in Northern and Western Europe. The population-based data for BCC from Lithuania are closely comparable, with regard to age, tumour localization and place of residence, with the existing literature from other European cancer registries.
Reduced NKG2D ligand expression in hepatocellular carcinoma correlates with early recurrence
Authors: Hiroteru Kamimura, Satoshi Yamagiwa, Atsunori Tsuchiya, Masaaki Takamura, Yasunobu Matsuda, Shogo Ohkoshi, Makoto Inoue, Toshifumi Wakai, Yoshio Shirai, Minoru Nomoto, Yutaka Aoyagi
Journal: Journal of Hepatology (2011)
Involvement of endoplasmic reticulum (ER) stress in podocyte injury induced by excessive protein accumulation
Authors: Reiko Inagi, Masaomi Nangaku, Hiroshi Onogi, Hiroshi Ueyama, Yasuko Kitao, Kiyokazu Nakazato, Satoshi Ogawa, Kiyoshi Kurokawa, William G. Couser, Toshio Miyata
Journal: Kidney International (2005)
Regional myocardial perfusion in patients with atherosclerotic coronary artery disease, at rest and during angina pectoris induced by tachycardia.
Authors: A Maseri, A L'Abbate, A Pesola, C Michelassi, M Marzilli, M De Nes
Journal: Circulation (1977)

We studied regional myocardial perfusion by scintigraphic computer-assisted analysis of initial distribution, washout rates, and residual activity of 133Xe injected into the left coronary artery of four patients with normal arteriograms and 14 patients with coronary stenosis. At rest, residual activity in poststenotic regions was always greater than in control regions, but initial washout rates were not slower. During angina, following xenon injections, the amount of indicator distributed to the poststenotic regions was markedly reduced; the increase of the initial washout rates was smaller than in control regions relative to rest, and residual activity was higher. Initial washout rates did not differ as much as from those of normal myocardium because in severe ischemia too little indicator is deposited initially in these regions to produce a change of any magnitude. Indeed, when angina was induced immediately after the xenon injection, poststenotic washout rates became much slower during angina than at rest, a finding that implicates functional factors in impairing poststenotic myocardial perfusion during angina.
Herpetic Eye Disease Study
Authors: Bruce A. Barron, Lauren Gee, Walter W. Hauck, Natalie Kurinij, Chandler R. Dawson, Dan B. Jones, Kirk R. Wilhelmus, Herbert E. Kaufman, Joel Sugar, Robert A. Hyndiuk, Peter R. Laibson, R. Doyle Stulting, Penny A. Asbell, Chandler R. Dawson, Todd P. Margolis, Robert A. Nozik, H. Bruce Ostler, Bruce A. Barron, Michael S. Insler, Herbert E. Kaufman, Dan B. Jones, Alice Y. Matoba, Kirk R. Wilhelmus, R. Doyle Stulting, George O. Waring, Louis A. Wilson, Robert A. Hyndiuk, Steven B. Koenig, Bruce M. Massaro, Penny A. Asbell, Andrew P. Davis, Michael J. Newton, Joel Sugar, Sheridan Lam, Jeffrey B. Robin, Howard H. Tessler, Peter R. Laibson, Elisabeth J. Cohen, Kent G. Leavitt, Christopher J. Rapuano, Walter W. Hauck, Lauren Gee, Jon E. Hidayat, Chandler R. Dawson, Walter W. Hauck, Dan B. Jones, Herbert E. Kaufman, Natalie Kurinij, Shrikant Bangdiwala, William E. Barlow, John W. Chandler, Lawrence J. Nelson, Anthony B. Nesburn, Chandler R. Dawson, Lauren Gee, Walter W. Hauck, Jon E. Hidayat, Natalie Kurinij, Kirk R. Wilhelmus, Lawrence M. Merin, Loretta A. Todaro
Journal: Ophthalmology (1994)
667 EARLY DETECTION OF HEPATITIS C USING A ONE MINUTE VISUAL QUALITATIVE BASED KIT SYSTEM IN A COMMUNITY BASED SETTING IN DOHA, QATAR
Authors: M. Sharma, K. Matar, N.A. Dweik, S.A. Kaabi, A.K. John, M.A. Mohannadi, M.F. Derbala, A.A. Amin, F. Pasic, R. Yakoob, T. Butt
Journal: Journal of Hepatology (2010)
The clinical spectrum of dystrophic epidermolysis bullosa
Authors: H.M. Horn, M.J. Tidman
Journal: British Journal of Dermatology (2002)

Summary Background Dystrophic epidermolysis bullosa (DEB) is a genodermatosis resulting from mutations in COL7A1, the gene encoding type VII collagen. The site and specific nature of the underlying mutation determine the clinical phenotype, which ranges widely from a severe mutilating condition to a relatively mild disorder. Objectives To document the clinical spectrum of DEB within a defined complete population. Methods Since 1992, when compilation of the U.K. epidermolysis bullosa register began, an exhaustive search for DEB sufferers within the Scottish population has been undertaken and their clinical features comprehensively recorded. Results One hundred and twenty-eight DEB sufferers have been identified within the Scottish population. In descending order, the frequencies of the different forms of DEB were dominant DEB (DDEB) in 88 individuals (68%), DEB of uncertain inheritance in 24 (19%) and recessive DEB (RDEB) in 16 patients (13%). Within this latter group, nine (7%) had the mutilating Hallopeau–Siemens subtype (RDEB-HS), five (4%) had localized (RDEB-loc) and two (2%) had a predominantly flexural (inverse) form of RDEB. During the study, two patients with RDEB died from squamous cell carcinomas (SCCs), one originating in the skin and the second arising in the oesophagus. Gastrointestinal problems such as dysphagia, constipation and anal fissures, and restriction of mouth opening were experienced by the majority of patients with RDEB and by a significant minority of DDEB sufferers. Pseudosyndactyly was most severe in RDEB-HS, all those over 9 years of age having mitten deformities of the hands. Milder pseudosyndactyly or flexion contractures of the fingers were present in younger patients with this subtype, in most adults suffering from other subtypes of RDEB and in 6% of those with DDEB. External ear involvement, a feature not often reported in DEB, was common in RDEB and also occurred in a minority of those with DDEB. Pruriginous lesions and albopapuloid lesions were each present in both DDEB and RDEB. Conclusions Most patients with DEB have relatively mild dominantly inherited disease, only a minority suffering from severe recessive subtypes. Scarring, gastrointestinal involvement, albopapuloid lesions and a pruriginosa-like pattern each occur in both DDEB and RDEB. With increasing age, SCC is a major cause of morbidity and mortality.
FATE OF THE LYMPHOCYTE
Authors: C. H. Bunting, John Huston
Journal: The Journal of Experimental Medicine (1921)

Although the count of circulating lymphocytes in the blood stream remains constant, more lymphocytes enter the blood from the thoracic duct during 24 hours than are present in the blood at any one time. This excess of lymphocytes is not destroyed in the blood stream. The cells migrate from the blood vessels into the mucous membranes and through them to their surface. This occurs chiefly in the gastrointestinal tract, and it is apparently in the mucosa and especially within the intestinal lumen that the function of the lymphocyte is normally performed.
Propoxyphene Hydrochloride Poisoning
Authors: Ehsan H. Qureshi
Journal: JAMA (1964)

PROPOXYPHENE HYDROCHLORIDE (Darvon) was synthesized by Pohland and Sullivan in 1953.<sup>1</sup>Related pharmacologically to codeine and widely used as an analgesic, the drug is available in 32- or 65-mg capsules, which is the recommended single adult dose. It is also marketed with acetophenetidin, acetylsalicylic acid, and caffeine as a compound. A case of severe intoxication due to propoxyphene hydrochloride associated with convulsions, coma, abnormal electrocardiogram (ECG), and respiratory arrest is reported. <h3>Report of a Case</h3> An 18-year-old married white female was brought to the hospital emergency room at 10:00 AM on April 6, 1963, in coma. She had ingested twenty-six 32-mg capsules of propoxyphene hydrochloride (832 mg) at about 8:00 AM. Approximately one-half hour later she became drowsy and acted as if inebriated. At about 9:00 AM the patient suffered four successive generalized convulsions which were followed by cyanosis and coma. History included an episode of possible labyrinthitis in
Normocalcemia is maintained in mice under conditions of calcium malabsorption by vitamin D–induced inhibition of bone mineralization
Authors: Liesbet Lieben, Ritsuko Masuyama, Sophie Torrekens, Riet Van Looveren, Jan Schrooten, Pieter Baatsen, Marie-Hélène Lafage-Proust, Tom Dresselaers, Jian Q. Feng, Lynda F. Bonewald, Mark B. Meyer, J. Wesley Pike, Roger Bouillon, Geert Carmeliet
Journal: Journal of Clinical Investigation (2012)

Serum calcium levels are tightly controlled by an integrated hormone-controlled system that involves active vitamin D [1,25(OH)(2)D], which can elicit calcium mobilization from bone when intestinal calcium absorption is decreased. The skeletal adaptations, however, are still poorly characterized. To gain insight into these issues, we analyzed the consequences of specific vitamin D receptor (Vdr) inactivation in the intestine and in mature osteoblasts on calcium and bone homeostasis. We report here that decreased intestinal calcium absorption in intestine-specific Vdr knockout mice resulted in severely reduced skeletal calcium levels so as to ensure normal levels of calcium in the serum. Furthermore, increased 1,25(OH)(2)D levels not only stimulated bone turnover, leading to osteopenia, but also suppressed bone matrix mineralization. This resulted in extensive hyperosteoidosis, also surrounding the osteocytes, and hypomineralization of the entire bone cortex, which may have contributed to the increase in bone fractures. Mechanistically, osteoblastic VDR signaling suppressed calcium incorporation in bone by directly stimulating the transcription of genes encoding mineralization inhibitors. Ablation of skeletal Vdr signaling precluded this calcium transfer from bone to serum, leading to better preservation of bone mass and mineralization. These findings indicate that in mice, maintaining normocalcemia has priority over skeletal integrity, and that to minimize skeletal calcium storage, 1,25(OH)(2)D not only increases calcium release from bone, but also inhibits calcium incorporation in bone.
Letter: Use of intravenous urography.
Authors: W F Hendry
Journal: BMJ (1974)

together with uterine contractions and signs of fetal irritability.Relief was achieved with a pethidine injection.The relationship of the heparin injection to the uterine contraction was noticed but we decided to continue the treatment.After the second dose of heparin six hours later the patient immediately had the same abdominal pain, which was again relieved by pethidine.At this point we became sure that the uterine contractions were due to the heparin injections.Heparin was stopped, no other anticoagulants were given, and the patient was treated conservatively.So far as we know no such reaction to heparin has been reported before.We thought of a small retroplacental haemorrhage due to heparin as a possible cause of pain, but the speed of the reaction and the relatively small dose of heparin and absence of complications afterwards made this un- likely.-Weare, etc.,
Comparative Trial of Tetracycline, Chloramphenicol, and Trimethoprim Sulphamethoxazole in Eradication of Vibrio cholera El Tor
Authors: R. A. Gharagozloo, K. Naficy, M. Mouin, M. H. Nassirzadeh, R. Yalda
Journal: BMJ (1970)

A comparison of tetracycline, chloramphenicol, and trimethoprim/sulphamethoxazole showed that all hasten the eradication of Vibrio cholerae from the stools of patients with cholera. A four-day period of tetracycline or trimethoprim/ sulphamethoxazole was adequate for eradicating V. cholerae from the stools of all patients, but three days, as suggested by the W.H.O. Expert Committee, was not. Four days of chloramphenicol therapy was sufficient for most patients, but a minority required up to seven days9 therapy. Purging produced reappearance of V. cholerae in the stools of one-eighth of the patients who had had three successive daily negative stool cultures; such patients are a potential danger to the population.
Methodological aspects of the use of heart rate stratified RR interval histograms in the analysis of atrioventricular conduction during atrial fibrillation
Authors: N. CAI, M. DOHNAL, S B. OLSSON
Journal: Cardiovascular Research (1987)

Journal Article Methodological aspects of the use of heart rate stratified RR interval histograms in the analysis of atrioventricular conduction during atrial fibrillation Get access NAISHENG CAI, NAISHENG CAI From the Division of Cardiology, Department of Medicine I, Sahlgrenska Hospital, Gothenberg, Sweden Address for correspondence and reprints: Dr S Bertil Olsson, Division of Cardiology, Department of Medicine I, Sahlgrenska Hospital, S-413 45 Goteborg, Sweden. Search for other works by this author on: Oxford Academic PubMed Google Scholar MICHAL DOHNAL, MICHAL DOHNAL From the Division of Cardiology, Department of Medicine I, Sahlgrenska Hospital, Gothenberg, Sweden Search for other works by this author on: Oxford Academic PubMed Google Scholar S BERTIL OLSSON S BERTIL OLSSON From the Division of Cardiology, Department of Medicine I, Sahlgrenska Hospital, Gothenberg, Sweden Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 21, Issue 6, June 1987, Pages 455–462, https://doi.org/10.1093/cvr/21.6.455 Published: 01 June 1987 Article history Received: 12 March 1986 Accepted: 06 November 1986 Published: 01 June 1987
Chromosomal Abnormalities in the Offspring of a Renal Transplant Recipient.
Authors: Daniel E. Leb
Journal: Annals of Internal Medicine (1970)

Meeting Abstracts1 May 1970Chromosomal Abnormalities in the Offspring of a Renal Transplant Recipient.Daniel E. Leb, M.D., F.A.C.P., Bob S. Kanovitz, M.D., Bernard Weisskopf, M.D.Daniel E. Leb, M.D., F.A.C.P.Search for more papers by this author, Bob S. Kanovitz, M.D.Search for more papers by this author, Bernard Weisskopf, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-72-5-805_4 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo date only five successful pregnancies in renal allograft recipients have been reported. Data on the adverse effects of azathioprine and prednisone on the fetus in the allograft situation is sketchy.Eighteen months before delivery, this 26-year-old white woman received a cadaver kidney transplant after being on hemodialysis. The patient was found to have an entirely normal response to pregnancy. Renal clearance of creatinine increased as would be expected. Late in pregnancy edema, hypertension, and proteinuria developed, suggesting that preeclampsia could occur in the allograft.Immunosuppression continued throughout pregnancy. Azathioprine dosage was reduced from 150 mg/day to 100 mg/day and... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Louisville, Ky. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1970Volume 72, Issue 5Page: 805-806KeywordsChromosomesCreatinineEdemaFetusesHypertensionPreeclampsiaPregnancyProteinuriaRenal transplantationResearch design ePublished: 1 December 2008 Issue Published: 1 May 1970 PDF downloadLoading ...