tbuckley/cabot-search huggingface dataset:
Video: The Testimony Archive
Authors: R. Persaud
Journal: BMJ (2000)

National Life Story Collection, British Library National Sound Archive, London NW1 2DB 

24 minute video also available from Mental Health Media

When we think of history, we tend to think about books, documents, and museums, but the National Life Story Collection at the British Library National Sound Archive proposes that history is all around us. It is in our own families and communities, particularly in the living memories and experiences of older people.

Established in 1987 to record first hand experiences of as wide a cross section of present day society as possible, the National Life Story Collection has now added …
Frozen Pre-embryos-Reply
Authors: Raymond C. Grandon
Journal: JAMA (1990)

In Reply.—  We agree with Davis, Brown, and Pannor that frozen pre-embryos should not be sold, and our report did not suggest otherwise. We do not agree that donating pre-embryos is like treating the end product as a commodity that can be bartered at will. The altruistic sentiments that motivate a couple to donate its unused pre-embryos to other childless couples are very different from the commercial sentiments that would motivate a couple to sell its unused preembryos.  Davis, Brown, and Pannor appear to overstate the concerns about the psychological implications of donating frozen pre-embryos. Any predictions of emotional problems are speculative. Perhaps the resulting children will have a heightened risk of emotional problems. Even so, it is difficult to conclude that they would have been better off not being born. In addition, it is not clear that studies of adopted children can be generalized to children who are the
Guidance of Radiofrequency Endocardial Ablation With Real-time Three-dimensional Magnetic Navigation System
Authors: Shlomo Shpun, Lior Gepstein, Gal Hayam, Shlomo A. Ben-Haim
Journal: Circulation (1997)

Background Ablation therapy for certain arrhythmias requires the formation of complex lesions based on electrical and anatomic mapping. We tested the accuracy and reproducibility of a nonfluoroscopic mapping and navigation (NFM) system to guide delivery of radiofrequency (RF) energy in the right atrium (RA) of swine. Methods and Results The NFM system uses an ultralow magnetic field to measure the real-time three-dimensional (3D) location of the tip of the locatable catheter. While in stable contact with the endocardium, between 30 and 40 consecutive tip locations were sampled and used for the 3D reconstruction of the RA geometry. The location of the catheter tip was presented in real time, superimposed over the RA geometry. We selected a point on the 3D reconstruction and delivered RF energy to that site via the tip of the locatable catheter. The catheter was then completely withdrawn and renavigated twice to the same point, at which RF energy was delivered again. At autopsy, the distance between the centers of the three ablation points (mean±SEM) was 2.3±0.5 mm (n=27). Similarly, we used the NFM system to guide the generation of linear lesions. The measured length of the linear lesions on the NFM 3D view was close to the actual lesion length measured at autopsy (correlation coefficient, .96; P =.002; n=6). Furthermore, the location, shape, and continuity of the linear lesions corresponded to the autopsy findings. Conclusions We conclude that the NFM system can guide the application of RF energy without the use of fluoroscopy in a highly accurate and reproducible manner.
The Effect of Federal Regulations Regarding Handicapped Newborns
Authors: Donald L. Shapiro
Journal: JAMA (1984)

A physician and an attorney from the Strong Memorial Hospital at the University of Rochester present a case report of how the federal "Baby Doe" regulations affected the care of conjoined twins born at their facility. The infants, whose anomalies made surgical separation impossible and death imminent, were nonetheless transferred back for further evaluation from a community hospital to the university's neonatal intensive care unit. A federal investigative team visited the facility briefly after the Department of Health and Human Services was anonymously informed of the infants' presence. The twins died shortly after being transferred back to the local hospital. Shapiro and Rosenberg assess the negative impact that the threat of federal intervention had on the infants' course of treatment and on the emotions of parents and staff, and conclude that this case exemplified the disruption of care that was predicted when the federal regulations were promulgated.
Payment and the Future of Primary Care
Authors: Robert A. Murden
Journal: Annals of Internal Medicine (2004)

Letters6 January 2004Payment and the Future of Primary CareRobert A. Murden, MDRobert A. Murden, MDFrom Ohio State University, Columbus, OH 43210.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-140-1-200401060-00027 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I applaud the editorial by Ginsburg (1) on payment and primary care. He has highlighted a major financial issue in primary care—the increasing expectations from patients, insurers, and others for management outside of office visits and thus not reimbursed. I present the following figures from an academic general internal medicine practice in support of Ginsburg's position and to demonstrate the magnitude of this issue.During a recent 6-month period, I provided 698 office visits in a 30% clinical practice. In that period, I personally provided 2513 services outside of office visits, or 3.6 per visit. These consisted ...References1. Ginsburg PB. Payment and the future of primary care [Editorial]. Ann Intern Med. 2003;138:233-4. [PMID: 12558364] LinkGoogle Scholar2. Maguire P. Taking a tough stand on non-billable care. ACP-ASIM Observer. 2003;23:1,16-17. Google Scholar Author, Article, and Disclosure InformationAuthors: Robert A. Murden, MDAffiliations: From Ohio State University, Columbus, OH 43210. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoPayment and the Future of Primary Care Paul B. Ginsburg Metrics Cited byThe Underuse of Medicare's Prevention and Coordination Codes in Primary Care A Cross-Sectional and Modeling StudySumit D. Agarwal, MD, MPH, Sanjay Basu, MD, PhD, and Bruce E. Landon, MD, MBA, MSc 6 January 2004Volume 140, Issue 1Page: 70KeywordsAcademic medicineForecastingHealth insuranceMotivationPatients ePublished: 6 January 2004 Issue Published: 6 January 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Successful treatment of scalp actinic keratoses with photodynamic therapy using ambient light
Authors: R.J. Batchelor, G.I. Stables, M.R. Stringer
Journal: British Journal of Dermatology (2007)

Journal Article Successful treatment of scalp actinic keratoses with photodynamic therapy using ambient light Get access R.J. Batchelor, R.J. Batchelor Department of Dermatology, Leeds General Infirmary, Leeds LS1 3EX, U.K.Institute of Microwaves and Photonics, School of Electronic and Electrical Engineering, University of Leeds, Leeds LS2 9JT, U.K. E‐mail:rjbatchelor@doctors.org.uk Search for other works by this author on: Oxford Academic Google Scholar G.I. Stables, G.I. Stables Department of Dermatology, Leeds General Infirmary, Leeds LS1 3EX, U.K.Institute of Microwaves and Photonics, School of Electronic and Electrical Engineering, University of Leeds, Leeds LS2 9JT, U.K. E‐mail:rjbatchelor@doctors.org.uk Search for other works by this author on: Oxford Academic Google Scholar M.R. Stringer M.R. Stringer Department of Dermatology, Leeds General Infirmary, Leeds LS1 3EX, U.K.Institute of Microwaves and Photonics, School of Electronic and Electrical Engineering, University of Leeds, Leeds LS2 9JT, U.K. E‐mail:rjbatchelor@doctors.org.uk Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 156, Issue 4, 1 April 2007, Pages 779–781, https://doi.org/10.1111/j.1365-2133.2007.07755.x Published: 01 April 2007
Inhaled Iloprost for Severe Pulmonary Hypertension
Authors: Horst Olschewski, Gerald Simonneau, Nazzareno Galiè, Timothy Higenbottam, Robert Naeije, Lewis J. Rubin, Sylvia Nikkho, Rudolf Speich, Marius M. Hoeper, Jürgen Behr, Jörg Winkler, Olivier Sitbon, Wladimir Popov, H. Ardeschir Ghofrani, Alessandra Manes, David G. Kiely, Ralph Ewert, Andreas Meyer, Paul A. Corris, Marion Delcroix, Miguel Gomez-Sanchez, Harald Siedentop, Werner Seeger
Journal: New England Journal of Medicine (2002)

Uncontrolled studies suggested that aerosolized iloprost, a stable analogue of prostacyclin, causes selective pulmonary vasodilatation and improves hemodynamics and exercise capacity in patients with pulmonary hypertension.
Prevalence and Prognostic Significance of Wall-Motion Abnormalities in Adults Without Clinically Recognized Cardiovascular Disease
Authors: Silvana Cicala, Giovanni de Simone, Mary J. Roman, Lyle G. Best, Elisa T. Lee, Wenyu Wang, Thomas K. Welty, James M. Galloway, Barbara V. Howard, Richard B. Devereux
Journal: Circulation (2007)

Background— Left ventricular wall motion (WM) abnormalities have recognized prognostic significance in patients with coronary or other heart diseases; however, whether abnormal WM predicts adverse events in adults without overt cardiovascular disease has not been assessed. Our objective was to determine whether echocardiographic WM abnormalities predict subsequent cardiovascular events in a population-based sample. Methods and Results— Participants (n=2864, mean age 60±8 years, 64% women) without clinically evident cardiovascular disease in the second Strong Heart Study examination who had complete echocardiographic WM assessment were studied. Echocardiographic assessment revealed that 5% of participants (n=140) had focal hypokinesia, and 1.5% (n=42) had WM abnormalities. Relationships between WM abnormalities and fatal and nonfatal cardiovascular events (including myocardial infarction, stroke, coronary artery disease, and heart failure; n=554) and cardiovascular death (n=182) during 8±2 years follow-up were examined. In Cox regression, after adjustment for age, gender, waist/hip ratio, systolic blood pressure, and diabetes mellitus, segmental WM abnormalities were associated with a 2.5-fold higher risk of cardiovascular events and a 2.6-fold higher risk of cardiovascular death (both P &lt;0.0001). In similar multivariable models, global WM abnormalities were associated with a 2.4-fold higher risk of cardiovascular events ( P =0.001) and a 3.4-fold higher risk of cardiovascular death ( P =0.003). Conclusions— Echocardiographic left ventricular WM abnormalities in adults without overt cardiovascular disease are associated with 2.4- to 3.4-fold higher risks of cardiovascular morbidity and mortality, independent of established risk factors.
ON THE ORIGIN OF HEPARIN
Authors: Jean Oliver, Frank Bloom, Carmen Mangieri
Journal: The Journal of Experimental Medicine (1947)

1. The spontaneous mast cell tumor of the dog contains heparin. 2. The cytoplasmic particulate content of the tumor mast cells varies with their anaplasia. This conclusion is based on the following findings: (a) in the immature cell of the more malignant tumor the particulate matter appeared in the living cells by phase microscopy to be composed of greyish illdefined particles or as a fine, weakly metachromatic granulation in the fixed and stained preparation; (b) in the mature cells of a relatively benign mast cell tumor, both in the living cell and in stained preparations, the particulate matter occurred in the form of discrete, dense, and strongly metachromatic granules, resembling those of the normal mast cell. 3. The heparin content was large (fifty times that of dog liver) in the growth with mature cells and only moderate (1.7 times) in that with immature cells. 4. Since there may be a great amount of greyish particulate matter (or fine stained granules) in a tumor of relatively low heparin content, it is suggested that this material represents an early or precursor phase in the development of heparin. 5. This possibility and the fact that the blood stream may be invaded by mature tumor mast cells of large heparin content without evident disturbance in the coagulability of the blood suggest the value of a comprehensive biochemical study of the heparin of mast cell tumors.
Activation of Inward Rectifier Potassium Channels Accelerates Atrial Fibrillation in Humans
Authors: Felipe Atienza, Jesús Almendral, Javier Moreno, Ravi Vaidyanathan, Arkazdi Talkachou, Jérôme Kalifa, Angel Arenal, Julian P. Villacastín, Esteban G. Torrecilla, Ana Sánchez, Robert Ploutz-Snyder, José Jalife, Omer Berenfeld
Journal: Circulation (2006)

Background— It is unclear whether atrial fibrillation (AF) drivers in humans are focal or reentrant. To test the hypothesis that functional reentry is involved in human AF maintenance, we determined the effects of adenosine infusion on local dominant frequency (DF) at different atrial sites. By increasing inward rectifier potassium channel conductance, adenosine would increase DF of reentrant drivers but decrease it in the case of a focal mechanism. Methods and Results— Thirty-three patients were studied during AF (21 paroxysmal, 12 persistent) using recordings from each pulmonary vein–left atrial junction (PV-LAJ), high right atrium, and coronary sinus. DFs were determined during baseline and peak adenosine effect. In paroxysmal AF, adenosine increased maximal DF at each region compared with baseline (PV-LAJ, 8.03±2.2 versus 5.7±0.8; high right atrium, 7±2.2 versus 5.4±0.7; coronary sinus, 6.6±1.1 versus 5.3±0.7 Hz; P =0.001) and increased the left-to-right DF gradient ( P =0.007). In contrast, in persistent AF, adenosine increased DF only in the high right atrium (8.33±1.1 versus 6.8±1.2 Hz; P =0.004). In 4 paroxysmal AF patients, real-time DF mapping of the left atrium identified the highest DF sites near the PV-LAJ, where adenosine induced an increase in DF (6.7±0.29 versus 4.96±0.26 Hz; P =0.008). Finally, simulations demonstrate that the frequency of reentrant drivers accelerates proportionally to the adenosine-modulated inward rectifier potassium current. Conclusions— Adenosine accelerates drivers and increases frequency differently in paroxysmal compared with persistent human AF. The results strongly suggest that AF is maintained by reentrant sources, most likely located at the PV-LAJ in paroxysmal AF, whereas non-PV locations are more likely in persistent AF.
Zinc Metabolism in Sickle Cell Anemia
Authors: Harvey B. Niell
Journal: JAMA (1979)

Zinc metabolism was studied in 34 patients with sickle cell anemia in a steady state and in six patients during sickle cell crisis. The patients in steady state were found to have significantly lower plasma levels and higher urinary levels of zinc than the 50 healthy adults in the control group. During sickle cell crisis the plasma zinc levels dropped to a mean value of 0.54 μg/mL from a steady state value of 0.79 μg/mL. These results support the concept that zinc deficiency occurs in sickle cell anemia and that further drops occur in the serum zinc levels during sickle cell crisis. (<i>JAMA</i>242:2686-2687, 1979)
Children, Asthma, and Proton Pump Inhibitors
Authors: Fernando D. Martinez
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ATTITUDES OF SOLDIERS RETURNING FROM OVERSEAS SERVICE
Authors: WILLIAM CORWIN
Journal: American Journal of Psychiatry (1945)

1. Interviews with several thousand soldiers of the Army Air Forces reveal the development of specific attitudes towards return home, reaction to conditions found on arrival, further military duties, personal situations, and post-war adjustments. 2. One hundred officers and 100 enlisted men were interviewed in more detail to establish information of statistical value. 3. Significant differences exist between officers and enlisted men only with regard to desire to remain in service. 4. The returning soldier, apparently free from disabling neuropsychiatric symptoms, is found to contain a reservoir of anxiety-producing factors which modifies his outlook, and which provokes the development of resentment and hostility, particularly towards civilians and present social conditions. 5. The immediate and more distant effects of these attitudes are of significance, and require programs designed to effect an adequate adjustment of the soldier to future military duties, and to post-war needs for security and socio-economic stability.
Methoxyflurane and Nitrous Oxide as Obstetric Analgesics. I.--A Comparison by Continuous Administration
Authors: P. L. Jones, M. Rosen, W. W. Mushin, E. V. Jones
Journal: BMJ (1969)

Methoxyflurane and nitrous oxide have been compared as obstetric analgesics. The inhaled concentrations of these agents, given continuously, were adjusted by an anaesthetist to maintain each patient at the optimum state between reaction to pain and consciousness. Assessments were made continuously. Though the anaesthetist9s assessment showed no difference between the mean results, a greater proportion of the methoxyflurane patients were “satisfactory” for 90–100% of the time than of the nitrous oxide patients, particularly in regard to objective pain relief. The midwives9 opinion of those who had “complete” pain relief supported this. Nausea was significantly less among methoxyflurane patients, and vomiting during labour occurred only in patients who had nitrous oxide. It is concluded that nitrous oxide and methoxyflurane given in a continuously adjusted concentration are almost equally effective as obstetric analgesics, though there are certain features which favour methoxyflurane.
James Russell Dickson
Authors: J. Toynton
Journal: BMJ (2009)

Attention can be voluntarily directed to a location or automatically summoned to a location by a salient stimulus. We compared the effects of voluntary and stimulus-driven shifts of spatial attention on the blood oxygenation level-dependent signal in humans, using a method that separated preparatory activity related to the initial shift of attention from the subsequent activity caused by target presentation. Voluntary shifts produced greater preparatory activity than stimulus-driven shifts in the frontal eye field (FEF) and intraparietal sulcus, core regions of the dorsal frontoparietal attention network, demonstrating their special role in the voluntary control of attention. Stimulus-driven attentional shifts to salient color singletons recruited occipitotemporal regions, sensitive to color information and part of the dorsal network, including the FEF, suggesting a partly overlapping circuit for endogenous and exogenous orienting. The right temporoparietal junction (TPJ), a core region of the ventral frontoparietal attention network, was strongly modulated by stimulus-driven attentional shifts to behaviorally relevant stimuli, such as targets at unattended locations. However, the TPJ did not respond to salient, task-irrelevant color singletons, indicating that behavioral relevance is critical for TPJ modulation during stimulus-driven orienting. Finally, both ventral and dorsal regions were modulated during reorienting but significantly only by reorienting after voluntary shifts, suggesting the importance of a mismatch between expectation and sensory input.
Judicial punishments in Iraq
Authors: D M Forrest
Journal: BMJ (1994)

EDITOR,—Reports in the BMJ have drawn attention to a series of recent decrees of the Iraqi Revolutionary Command Council introducing amputation of the right hand as judicial punishment for theft, with amputation of the left foot for a second offence.1 2 Amputation of one ear is decreed as punishment for evasion of the draft, military desertion, or harbouring deserters. Amputation of the other pinna is the penalty for a second offence, and the death penalty is decreed for a third. In addition, an X is branded on to the forehead. It seems that these sentences …
Coronary angiographic morphology in myocardial infarction: A link between the pathogenesis of unstable angina and myocardial infarction
Authors: John A. Ambrose, Stephen L. Winters, Rohit R. Arora, Jacob I. Haft, Jonathan Goldstein, K. Peter Rentrop, Richard Gorlin, Valentin Fuster
Journal: Journal of the American College of Cardiology (1985)
Abstract 2985: The histone demethylase JMJD1A induces neuroblastoma cell migration and invasion.
Authors: Dora Ling, Andrew Tee, Charlotte Nelson, Ning Xu, Bernard Atmadibrata, Pei Y. Liu, Eddy Pasquier, Glenn M. Marshall, Takayoshi Suzuki, Yi Zhang, Tao Liu
Journal: Cancer Research (2013)

Abstract Patients with neuroblastoma due to N-Myc oncogene-amplification die of tumour metastasis. However, little is known about how N-Myc induces cell migration, invasion and metastasis. The histone demethylase JMJD1A activates target gene transcription by demethylating lysine 9 residues of histone H3 (H3K9). Here we demonstrated that N-Myc up-regulated the expression of JMJD1A in N-Myc oncogene-amplified human neuroblastoma cells by directly binding to JMJD1A gene promoter. Affymetrix gene array studies revealed that the gene most significantly up-regulated by JMJD1A was the long intergenic noncoding RNA Metastasis-associated Lung Adenocarcinoma Transcript 1 (MALAT1). Consistent with this finding, chromatin immunoprecipitation showed that JMJD1A bound to MALAT1 gene promoter. Importantly, JMJD1A siRNAs, MALAT1 siRNAs and small molecule JMJD1A inhibitors impeded neuroblastoma cell migration and invasion. Taken together, our data identify a novel pathway through which N-Myc causes neuroblastoma cell migration, invasion and potentially metastasis. Citation Format: Dora Ling, Andrew Tee, Charlotte Nelson, Ning Xu, Bernard Atmadibrata, Pei Y. Liu, Eddy Pasquier, Glenn M. Marshall, Takayoshi Suzuki, Yi Zhang, Tao Liu. The histone demethylase JMJD1A induces neuroblastoma cell migration and invasion. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2985. doi:10.1158/1538-7445.AM2013-2985