tbuckley/cabot-search huggingface dataset:
Hypokalaemia and xipamide
Authors: P Weissberg, M J Kendall
Journal: BMJ (1982)

Hypokalaemia and xipamide SIR,-I read the paper entitled "Ventricular fibrillation induced by xipamide" (13 February, p 494) with great interest.We published a paper from this department in 1981,1 in which we drew attention to the fact that xipamide, although a very effective antihypertensive agent, caused profound re- ductions in the serum potassium concentra- tions, which were potentially dangerous, and recommended that it should not be used for this purpose unless adequate potassium supplements were given at the same time.'It is not clear to me, however, why the authors have included indapamide in their indictment of xipamide since their case report refers to a patient who was simply taking the latter drug and not the former.There are some chemical similarities between the two drugs, in that both are derivatives of chlorosulphonamide (xipamide is a salicylic acid derivative and indapamide an indoline derivative) but there would appear to be substantial pharma- cological differences between the two.Xipamide is undoubtedly a potent diuretic,2
Cutting Waste and Keeping Faith
Authors: Allan C. Denenberg
Journal: Annals of Internal Medicine (1998)

Letters1 December 1998Cutting Waste and Keeping FaithAllan C. Denenberg, MDAllan C. Denenberg, MDDenville, NJ 07834Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-129-11_Part_1-199812010-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I was deeply disturbed by Bloche's editorial “Cutting Waste and Keeping Faith” [1].The author states that “physicians risk running afoul of these statutes primarily through careless documentation and trying to be too clever.” He goes on to say “rather than railing against these confusing laws or, even worse, campaigning to broaden their exceptions, physicians should heed the sobering message the laws send-that Americans have lost faith in their physicians' ability to restrain themselves when tempted by money.”What nonsense! Why shouldn't physicians attempt to alter these unreasonable and capricious laws? Where does the author get the ...References1. Bloche MG. Cutting waste and keeping faith [Editorial]. Ann Intern Med. 1998; 129:688-9. Google Scholar Author, Article, and Disclosure InformationAuthors: Allan C. Denenberg, MDAffiliations: Denville, NJ 07834 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1998Volume 129, Issue 11_Part_1Page: 915KeywordsHealth careRunning ePublished: 15 August 2000 Issue Published: 1 December 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Propofol infusion for sedation in the intensive care unit:: Authors' reply
Authors: R M Grounds, J M Lalor, J. Lumley, D Royston, M Morgan
Journal: BMJ (1987)

AumoRs' REPLY-As Drs -Brown and Edwards suggest, the amounts ofsodium nitroprusside used in our two groups do seem to differ.We would point out, however, that.theuse of sodium nitro-
Observations on Prognosis in Hypertension
Authors: A. W. D. Leishman
Journal: BMJ (1953)

ConclusionOur experience, although diminutive, has confirmed the published opinions that radioactive phosphorus offers the most convenient means of controlling the haemo- poietic exuberance of polycythaemia rubra vera.In 80% of patients the blood count is restored to normal for at least a year, and the symptoms immediately attri- butable to its previous perversion are relieved ; the remainder are either resistant to this form of treatment or show leucopenia or thrombocytopenia sufficient to make it dangerous.Acute myeloblastic leukaemia is a more common termination in those given P32 than in those not so treated.The size of this risk remains to be assessed, and it will be some years before we can be certain that the mean survival is increased or the incidence of vascular and other complications lessened by treatment with radioactive phosphorus.
Ara H 2.02 Is A More Potent Cross-linker Of Anti- Peanut IgE Than Is Ara H 2.01
Authors: R. El Mezayen, L. Pons, A.W. Burks, M. West, S. Stanley, M. El Gazzar, M.W. Duncan, K.C. Hansen, S.C. Dreskin
Journal: Journal of Allergy and Clinical Immunology (2007)
How to grow a human
Authors: Michael C. Corballis
Journal: Behavioral and Brain Sciences (1996)

Abstract I enlarge on the theme that the brain mechanisms required for languageand other aspects of the human mind evolved through selective changes in the regulatory genes governing growth. Extension of the period of postnatal growth increases the role of the environment in structuring the brain, and spatiotemporal programming (heterochrony) ofgrowth might explain hierarchical representation, hemispheric specialization, and perhaps sex differences.
Cytomegalovirus Infection and HIV-1 Disease Progression in Infants Born to HIV-1–Infected Women
Authors: Andrea Kovacs, Mark Schluchter, Kirk Easley, Gail Demmler, William Shearer, Philip La Russa, Jane Pitt, Ellen Cooper, Johanna Goldfarb, David Hodes, Meyer Kattan, Kenneth McIntosh
Journal: New England Journal of Medicine (1999)

Cytomegalovirus (CMV) has been implicated as a cofactor in the progression of human immunodeficiency virus type 1 (HIV-1) disease. We assessed 440 infants (75 of whom were HIV-1–infected and 365 of whom were not) whose CMV status was known, who were born to HIV-1–infected women, and who were followed prospectively. HIV-1 disease progression was defined as the presence of class C symptoms (according to the criteria of the Centers for Disease Control and Prevention [CDC]) or CD4 counts of less than 750 cells per cubic millimeter by 1 year of age and less than 500 cells per cubic millimeter by 18 months of age.
Compulsory helmets for cyclists
Authors: J K Anand
Journal: Journal of the Royal Society of Medicine (2005)

Dr McNaught is right to point out examples of racism in the NHS (December 2004 JRSM 1 ).But what to do about it?Maybe we can learn some lessons from the past.Today there is an over-representation of black people in the mental health system but in the 1960s Irish people were over-represented. 2 Psychiatrists thought that the prevalence of schizophrenia was high in people from the west of Ireland and invented a new syndrome 'western seaboard psychosis'. 3 Anthropologists descended on the unsuspecting immigrants to ask them if their Catholic faith caused their minds to unbalance and psychiatrists followed to dole out antipsychotics.But then some proper research was done and it showed no excess of schizophrenia in Irish immigrants. 4 The methods of case collection in the early studies were poor and cross-cultural comparisons were not properly thought through. 3 Today Irish people are no more likely to be diagnosed with schizophrenia than anyone else.How did this happen?I would love to say that it was because of the new research or because of government initiatives.The research helped a bit but the main cures for anti-Irish discrimination were that the new immigrants were richer, better educated, better informed and more questioning.They would not be fobbed off with a misdiagnosis.An increasing understanding and appreciation of Irish culture also helped reduce anti-Irish discrimination generally.The most effective cure of all was time.A cynic would add that, nowadays, people have a new batch of immigrants (such as asylum seekers) to discriminate against.So we need fewer new policy drives and more changes of heart.These will only come from changes in society.Blaming individuals or even the NHS will not help.
Childhood immunisation in the new decade
Authors: I A. Arafeh, J A Carmichael
Journal: BMJ (1991)

at 9-10 months to 73% at )a15 months,' and in Thai children the mean antibody titres were 62, 75, and 92 after vaccination at 9-10, 11-12, and 13-14 months, respectively.4Even more serious is the adverse effect of an early dose on subsequent response: children vaccinated at both 8 and 15 months had a final antibody titre which was only 75% (p<00001) of that reached with a single dose at 15 months.'Nor is high dose Edmonston-Zagreb vaccine the manifest solution that Dr Rudd implies for those who advocate early measles vaccination: the titres in Gambian children who received this vaccine at 4 months were 60% lower even than those achieved with the usual dose of Schwarz vaccine at 9 months.As with diphtheria and polio, elimination depends on a high level of herd im- munity, best achieved by a maximal individual response.For measles (with mumps and rubella) this means waiting until 15 months in any country.The same reasoning applies to pertussis, except that the child gives a good immune response at a younger age and the whole schedule of three doses can be completed by 6 months, as Dr Rudd advocates.This is achieved world wide by a popular and effective schedule with doses at 3, 4, and 5 months.The wisdom of starting any earlier is
Identification of Hymenoptera venom–allergic patients with negative specific IgE to venom extract by using recombinant allergens
Authors: Liliana Cifuentes, Sebastian Vosseler, Simon Blank, Henning Seismann, Davide Pennino, Ulf Darsow, Reinhard Bredehorst, Johannes Ring, Martin Mempel, Edzard Spillner, Markus W. Ollert
Journal: Journal of Allergy and Clinical Immunology (2013)
Resistance to Paclitaxel Is Proportional to Cellular Total Antioxidant Capacity
Authors: Balakrishnan Ramanathan, Kun-Yan Jan, Chien-Hung Chen, Tzyh-Chyuan Hour, Hong-Jen Yu, Yeong-Shiau Pu
Journal: Cancer Research (2005)

Abstract Paclitaxel, one of the most commonly prescribed chemotherapeutic agents, is active against a wide spectrum of human cancer. The mechanism of its cytotoxicity, however, remains controversial. Our results indicate that paclitaxel treatment increases levels of superoxide, hydrogen peroxide, nitric oxide (NO), oxidative DNA adducts, G2-M arrest, and cells with fragmented nuclei. Antioxidants pyruvate and selenium, the NO synthase inhibitor Nω-nitro-l-arginine methyl ester, and the NO scavenger manganese (III) 2-(4-carboxyphenyl)-4,4,5,5-tetramethyl-imidazoline-1-oxyl-3-oxide all decreased paclitaxel-mediated DNA damage and sub-G1 cells. In contrast, the glutamylcysteine synthase inhibitor buthionine sulfoximine (BSO) and the superoxide dismutase (SOD) inhibitor 2-methoxyestradiol (2-ME) increased the sub-G1 fraction in paclitaxel-treated cells. These results suggest that reactive oxygen and nitrogen species are involved in paclitaxel cytotoxicity. This notion is further supported with the observation that concentrations of paclitaxel required to inhibit cell growth by 50% correlate with total antioxidant capacity. Moreover, agents such as arsenic trioxide (As2O3), BSO, 2-ME, PD98059, U0126 [mitogen-activated protein/extracellular signal-regulated kinase inhibitors], and LY294002 (phosphatidylinositol 3-kinase/Akt inhibitor), all of which decrease clonogenic survival, also decrease the total antioxidant capacity of paclitaxel-treated cells, regardless whether they are paclitaxel sensitive or paclitaxel resistant. These results suggest that paclitaxel chemosensitivity may be predicted by taking total antioxidant capacity measurements from clinical tumor samples. This, in turn, may then improve treatment outcomes by selecting out potentially responsive patients.
Food allergy is a matter of geography after all: sesame as a major cause of severe IgE-mediated food allergic reactions among infants and young children in Israel
Authors: I. Dalal, I. Binson, R. Reifen, Z. Amitai, T. Shohat, S. Rahmani, A. Levine, A. Ballin, E. Somekh
Journal: Allergy (2002)

To determine the prevalence, importance, and the order of frequency of IgE-mediated food allergens among infants and young children in Israel.In a cross-sectional study, the prevalence of IgE-mediated food allergy was investigated in 9070 infants and young children (0-2 years) who were followed-up at 23 Family Health Centers (FHCs) in central Israel. Patients with suspected IgE-mediated food allergic reactions, were recruited for further evaluation (detailed questionnaire and skin-prick test (SPT)).We identified 150 out of 9070 (1.7%) patients with suspected IgE-mediated food allergy. Among them, 102/150 (67%) [59 males, 43 females; mean age 10.3 months] completed a detailed questionnaire and underwent SPT. Evaluation revealed 131 positive SPTs in 78/102 (76.5%) patients. Twenty-seven positive SPTs in 18 patients were considered clinically irrelevant based on previous consumption of the relevant foods without clinical symptoms. Thus, there were 104 relevant positive SPTs in 78 patients. The overall prevalence of clinically relevant IgE-mediated food allergic reactions among these patients is estimated to be 1.2% (104/9070). The most common food allergens were egg, cow's milk, and sesame. Anaphylaxis was the presenting symptom in 14/78 (18%) including six sesame-induced cases. A history of other atopic diseases was reported in 27 (35%) patients. In addition, 22 (28%) had a history of atopy in first-degree family members.We found sesame to be a major cause of IgE-mediated food allergy in Israel. In fact, it is second only to cow's milk as a cause of anaphylaxis. We recommend that testing for food allergens be tailored to each community based on local experience and should include sesame in appropriate populations.
Markers for Prediction of Cardiovascular Disease Risk
Authors: Maryam Kavousi, Maarten J. G. Leening, Jacqueline C. M. Witteman
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A New Rapid Slide Test for Infectious Mononucleosis
Authors: Gail Hoff
Journal: JAMA (1965)

In 1911 Forssman<sup>1</sup>discovered that immunization of rabbits with sheep erythrocytes caused the production of an antibody which was toxic to guinea pigs and that guinea pig kidney contained an antigen which reacted with this rabbit antibody. The antigen of this system has come to be known as the Forssman antigen. Further studies<sup>2-4</sup>into the nature of the Forssman antibody revealed that it was but one of a family of heterophil antibodies, which have been characterized by Davidsohn and Walker<sup>5</sup>as "antibodies that have the ability to react with antigens that are apparently entirely unrelated to those which stimulated their production." In 1930, Davidsohn<sup>6</sup>showed that normal control subjects possess antisheep agglutinins of a heterophilic nature. It has since been shown that these heterophil antibodies found in control sera may or may not behave as classical Forssman antibodies.<sup>7</sup>Paul and Bunnell<sup>8</sup>and Bunnell<sup>9</sup>
Abstract A7: Neural regulation of metastasis: New avenues for therapeutic intervention
Authors: Caroline P. Le, Donald Lamkin, Ming G. Chai, Corina Kim, Matthew A. Pimentel, Steven W. Cole, Erica K. Sloan
Journal: Cancer Research (2013)

Abstract Recent clinical and experimental studies demonstrated that the neuroendocrine system accelerates cancer development and progression. To investigate the cellular and molecular mechanism of neuroendocrine regulation of cancer, we have used advanced in vivo imaging technologies to investigate spatial relationships between peripheral neural system, tumor cells and the metastatic microenvironment. We found that chronic activation of the sympathetic nervous system accelerates breast cancer metastasis to distant tissues. Increased metastasis was dependent on beta-adrenergic signaling which induced macrophage recruitment to primary tumors and induced a switch to pro-metastatic and pro-inflammatory gene expression. Our recent studies in orthotopic xenograft models of pancreatic cancer and leukemia showed that activation of neural stress-response pathways similarly accelerated disease progression, suggesting that adrenergic signaling may be a general physiological regulator of cancer progression. These findings raise the possibility that beta-blockade of neural stress response pathways may be a novel therapeutic strategy to slow or prevent metastasis. In addition, we will discuss findings that targeting peripheral nerve fibers may provide therapeutic leverage against metastasis. Citation Format: Caroline P. Le, Donald Lamkin, Ming G. Chai, Corina Kim, Matthew A. Pimentel, Steven W. Cole, Erica K. Sloan. Neural regulation of metastasis: New avenues for therapeutic intervention. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Invasion and Metastasis; Jan 20-23, 2013; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2013;73(3 Suppl):Abstract nr A7.
Should the Appendix Be Removed When the Abdomen Is Opened for Other Conditions?
Authors: Howard A. Kelly
Journal: JAMA (1904)

Baltimore, Oct. 4, 1904. <h3>To the Editor:</h3> —I beg leave to make a slight correction in an admirable article by Dr. Floyd McRae inThe Journal, Sept. 24, 1904, on "The Diagnosis of Appendicitis, Should the Appendix Be Removed When the Abdomen Is Opened for Other Conditions?" He writes as follows: "Kelly, in his classical work on gynecology, gives the opinion of a number of the leading surgeons and gynecologists in this question. Most of them were of the opinion that the removal of the appendix, unless markedly diseased, should not be a routine practice, the author agreeing with them." My remarks on this subject were published, not in my "Operative Gynecology," but in a paper entitled "Under What Circumstances Is It Advisable to Remove the Vermiform Appendix?" which appeared inThe Journalof the American Medical Association, Oct. 25, 1902. The point in regard to which I asked for
Rigid external resistances cause effort dependent maximal expiratory and inspiratory flows.
Authors: C F Melissant, J W Lammers, M Demedts
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

A fixed orifice or a fixed upper airway obstruction (UAO) causes an expiratory and inspiratory plateau-shaped limitation on maximal flow-volume (MEFV, MIFV) curves and, according to the classic concept, a MEF50/MIF50 ratio of 0.9-1.1. However, since maximal expiratory static transrespiratory pressures (PEmax,stat) are clearly greater than the inspiratory ones (PImax,stat), the pressures applied during forced expiration also must be expected to be greater than inspiratory pressures; therefore, the MEF should be larger than the MIF because orifice flow is effort-dependent. We investigated this hypothesis in seven healthy, nonsmoking male volunteers (mean age +/- 1 SD: 34 +/- 10 yr, FVC: 5.9 +/- 1.0 L, PEmax,stat: 168 +/- 16 cm H2O, PImax,stat: 107 +/- 33 cm H2O). They performed MEFV curves and MIFV curves through four different added resistances placed in between the pneumotachograph and the mouth (the orifice diameters ranged between 7.8 mm and 2.8 mm). During these maneuvers dynamic mouth pressures were also measured (PE and PI). We found that the MEF50/MIF50 ratios were significantly increased (p < 0.05) from a control value of 1.1 +/- 0.4 up to 1.5 +/- 0.3 with the resistances. For each added resistance the PE/MEF ratios and (-)PI/MIF ratios were situated on a single line corresponding with the pressure-flow (P/V) characteristics of the resistance. We concluded that external resistances cause a MEF50/MIF50 ratio of clearly more than 1 and that this is determined by the PE/(-)PI ratio, which in healthy subjects is markedly larger than 1.
Edinburgh poverty 1840
Authors: J. H. Baron
Journal: BMJ (2003)

Deficient nourishment, want of employment, and privations of all kinds, and the consequent mental depression...

Famine, destitution, and pestilence...

Female labourers live in a condition to which that of most domestic animals is a luxury.

Craig WS. History of the royal college of physicians of Edinburgh. Oxford: Blackwell, 1976: 18-22,43
Dual-Mode Modulation of Smad Signaling by Smad-Interacting Protein Sip1 Is Required for Myelination in the Central Nervous System
Authors: Qinjie Weng, Ying Chen, Haibo Wang, Xiaomei Xu, Bo Yang, Qiaojun He, Weinian Shou, Yan Chen, Yujiro Higashi, Veronique van den Berghe, Eve Seuntjens, Steven G. Kernie, Polina Bukshpun, Elliott H. Sherr, Danny Huylebroeck, Q. Richard Lu
Journal: Neuron (2012)
GAD65 Antibody Epitope Patterns of Type 1.5 Diabetic Patients Are Consistent With Slow-Onset Autoimmune Diabetes
Authors: Christiane S. Hampe, Ingrid Kockum, Mona Landin-Olsson, Carina Törn, Eva Örtqvist, Bengt Persson, Olov Rolandsson, Jerry Palmer, Åke Lernmark
Journal: Diabetes Care (2002)

Type 1.5 diabetes (1) is characterized by rapid loss of β-cell function, failure of oral agents, and acquirement of insulin requirement (2,3). These patients have islet cell antibodies (ICAs), GAD65 autoantibodies (GAD65Abs) (4,5,6), or both, indicating an underlying autoimmune pathogenesis. Therefore, the question of whether type 1.5 diabetes represents a separate clinical disease or a slowly progressive form of type 1 diabetes has been raised (7,8). The aim of the present study was to investigate whether GAD65Ab epitopes in type 1.5 diabetic patients differ from those found in type 1 diabetic patients and other GAD65Ab-positive phenotypes.

Type 1.5 diabetic patients ( n = 34) were identified as GAD65Ab-positive type 2 diabetic …
Spain cuts waiting times for surgery
Authors: X. Bosch
Journal: BMJ (1999)

Spain's national health service (INSALUD) reduced the mean waiting time for surgical procedures from three months to two during 1998.Patients are now waiting about five months less than they did in 1996,when the mean waiting time was about seven months.

These encouraging data were presented last month by the minister of health, Jose Manuel Romay-Beccaria, who …
PHOTOTOXIC BULLOUS ERUPTIONS DUE TO NALIDIXIC ACID
Authors: D. A. BIRKETT, M. GARRETTS, C. J. STEVENSON
Journal: British Journal of Dermatology (1969)

SUMMARY. Bullous phototoxic eruptions due to Nalidixic acid are recognized but very uncommon. We report details of 5 cases. Investigations for porphyria were carried out in 3 cases and were negative. Experimentally nalidixic acid did not cause photosensitivity in normal young men.
Pituitary corticotroph adenoma in a woman with long-standing addison’s disease: A histologic, immunocytochemical, electron microscopic, andIn Situ hybridization study
Authors: Kalman Kovacs, Lucia Stefaneanu, Eva Horvath, Michael Buchfelder, Rudolph Fahlbusch, Peter H. Althoff, Christine Moore
Journal: Endocrine Pathology (1996)
Hif-2α Promotes Degradation of Mammalian Peroxisomes by Selective Autophagy
Authors: Katharina M. Walter, Miriam J. Schönenberger, Martin Trötzmüller, Michael Horn, Hans-Peter Elsässer, Ann B. Moser, Miriam S. Lucas, Tobias Schwarz, Philipp A. Gerber, Phyllis L. Faust, Holger Moch, Harald C. Köfeler, Wilhelm Krek, Werner J. Kovacs
Journal: Cell Metabolism (2014)