tbuckley/cabot-search huggingface dataset:
Randomized controlled trial of a single dermatology nurse consultation in primary care on the quality of life of children with atopic eczema
Authors: D.J. Chinn, T. Poyner, G. Sibley
Journal: British Journal of Dermatology (2002)

Journal Article Randomized controlled trial of a single dermatology nurse consultation in primary care on the quality of life of children with atopic eczema Get access D.J. Chinn, D.J. Chinn Postgraduate Institute for Health, University of Teesside, Middlesbrough, TS1 3BA, U.K Dr David J Chinn. E‐mail: david.chinn@sunderland.ac.uk Search for other works by this author on: Oxford Academic Google Scholar T. Poyner, T. Poyner Queen's Park Medical Centre, 2 Farrer Street, Stockton‐on‐Tees, TS18 2AW, U.K Search for other works by this author on: Oxford Academic Google Scholar G. Sibley G. Sibley Queen's Park Medical Centre, 2 Farrer Street, Stockton‐on‐Tees, TS18 2AW, U.K Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 146, Issue 3, 1 March 2002, Pages 432–439, https://doi.org/10.1046/j.1365-2133.2002.04603.x Published: 01 March 2002 Article history Accepted: 12 September 2001 Published: 01 March 2002
TCT-458 Late Outcomes of Patients with Myocardial Infarction Undergoing Drug-Eluting Stent Implantation in Daily Clinical Practice
Authors: Ricardo Costa, Amanda Sousa, Jose Costa, Adriana Moreira, Galo Maldonado, Manuel Cano, Bruno Palmieri, Cantidio Campos Neto, Fausto Feres, Alexandre Abizaid, J. Eduardo Sousa
Journal: Journal of the American College of Cardiology (2012)
MR-1 blocks the megakaryocytic differentiation and transition of CML from chronic phase to blast crisis through MEK dephosphorylation
Authors: W Zhao, H He, K Ren, B Li, H Zhang, Y Lin, R-g Shao
Journal: Blood Cancer Journal (2013)

Chronic myelogenous leukemia (CML) evolves from a chronic phase characterized by the Philadelphia chromosome as the sole genetic abnormality and the accumulation of mature cells in peripheral blood into blast crisis, which is characterized by the rapid expansion of myeloid- or lymphoid-differentiation-arrested blast cells. Although ample studies have been conducted on the disease progress mechanisms, the underlying molecular mechanisms of the malignant phenotype transition are still unclear. In this study, we have shown that myofibrillogenesis regulator-1 (MR-1) was overexpressed in blast crisis patients and leukemic cells, but there was little trace expressed in healthy individuals and in most patients in CML chronic phase. MR-1 could inhibit the differentiation of myeloid cells into megakaryocytic lineages and accelerate cell proliferation. The molecular mechanism responsible for these effects was the interaction of MR-1 with MEK, which blocked the MEK/ERK signaling pathway by dephosphorylating MEK. Our results provide compelling and important evidence that MR-1 might act as a diagnostic marker and potential target of CML progression from chronic phase to blast crisis.
WHO calls for extra resources to step up fight against tuberculosis
Authors: John Zarocostas
Journal: BMJ (2008)

Governments need to scale up national programmes to fight and control tuberculosis, which remains a major cause of illness and death worldwide, says a new report from the World Health Organization.

In 2006 an estimated 9.2 million new cases and 1.7 million deaths from tuberculosis occurred worldwide, including 700 000 million cases and 200 000 deaths in HIV positive people, says WHO’s report. It estimates that the total number of cases in 2006 was 14.4 million.

Some progress has been achieved, the report says. The incidence per capita is falling worldwide, and the prevalence and death rate are also falling, and the decline is …
The old dead white guys' room
Authors: M. E Black
Journal: BMJ (2009)

The first black female South African minister of health was due to visit Harvard’s School of Public Health in the 1990s. I got lost during an advance recce of the venue. A helpful black janitor put me right. “You mean the old dead white guys’ room,” he said.

There they were, portraits of the great and the good, all white men except for one small blurry photo of a white woman. The story told was one of eminence and exclusion, of generations where many potential US leaders of public health could get in the …
Abstract 3163: Tissue-micro array based IHC analysis of mTOR activity in DLBCL
Authors: Tamas B. Sticz, Agnes Mark, Melinda Hajdu, Botond Timar, Karolina Nemes, Laszlo Kopper, Anna Sebestyen
Journal: Cancer Research (2011)

Abstract Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous group of diseases with several subtypes with differing responses to therapy. The standard initial therapy for DLBCL continues using regimens like R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone), regardless of the subtypes. Targeted therapy offers a new approach to improve clinical responses. mTOR signaling has been shown to be activated in several lymphomas. mTOR inhibitors are being developed and are in clinical use in mantle cell lymphoma (MCL) therapy and clinical trials are ongoing in other high grade lymphomas as well. However, there is limited data about mTOR activity in different DLBCLs. We evaluated immunohistochemical (IHC) results in biopsy materials from 79 DLBCL patients (42 females and 37 males, mean age 61 years), who were conventionally treated with R-CHOP, R-CEOP or CHOP therapy. Several antibodies (phospho-S6, phospho-p70S6K, phospho-mTOR, p-4EBP1, Mum1, CD10, bcl-6, bcl-2) were used and more than 700 IHC stainings were evaluated on TMA slides. Mum1, CD10 and bcl-6 staining helped to distinguish between germinal center (GC) and non-germinal center B-cell derived DLBCL cases. Approximately 30% of cases were characterized as GC-derived DLBCL, which showed virtually no mTOR activity, as determined by phosphorylated S6 (p-S6) expression, the most sensitive marker (only weak p-S6 expression was detected in 2 cases). However, in about 80% of non-GC lymphoma cases, p-S6, p-mTOR, p-p70S6K and p-4EBP1 positivity was observed, which alludes to mTOR activity. Although the importance of mTOR activity is well demonstrated by mTOR mediated cyclinD1 expression in MCL, no statistical correlation was found between mTOR activity and the expression of pro-proliferative or anti-apoptotic factors (such as bcl-2 and bcl-6) in the examined DLBCL cases. These results suggest that mTOR activity is characteristic in most non-GC derived DLBCLs. Similarly to MCL patients, those patients with poor survival may benefit from rapamycin derivatives or other treatments targeting mTOR. These rapalogs or other novel anti-mTOR agents may be used in addition to the regular R-CHOP therapy, however, patient selection criteria should be carefully considered. Supported by OTKA-K68341 and OTKA-K81624 Projects. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3163. doi:10.1158/1538-7445.AM2011-3163
Points: Psychosexual problems
Authors: R. Thexton
Journal: BMJ (1987)

causalgia.Clinical experience suggests that superficial mechanical stimulation of P6 is as effective as elec- trical stimulation, but confirmation by a properly controlled clinical trial is required. Dangers from dissolution of latex in Celestin endo-oesophageal tubeDr A E HANWELL (Keymed, Essex SS2 5QH) writes: Dr S A Hussain and others (14 February, p 413) state, in their report of the dangers of the disintegration of Celestin tubes, that this problem is well recognised, but is it?In addition to the five references listed with the case report we found a further five reports of similar disintegration, going back as far as 1976.'-5 For this period we cannot find a single report of similar problems encountered with a prosthesis constructed from silicone rubber, which is much more resistant to disintegration.6 1 Brown P, Hughes RG.Late complication of endoscopic oeso-
Comparison of test performance profile for blood tests of liver fibrosis in chronic hepatitis C
Authors: Philippe Halfon, Yannick Bacq, Anne De Muret, Guillaume Penaranda, Marc Bourliere, Denis Ouzan, Albert Tran, Danielle Botta, Christophe Renou, Marie-Claude Bréchot, Claude Degott, Valérie Paradis
Journal: Journal of Hepatology (2006)
Granuloma collagenase and EDTA-sensitive neutral protease production in hepatic murine schistosomiasis
Authors: Shizuko Takahashi, Edwin Simpser
Journal: Hepatology (1981)

Mice infected with Schistosoma mansoni represent a model for study of hepatic fibrosis in humans. Production of trypsin-activatable inactive collagenase and EDTA-sensitive neutral protease was measured in the culture medium in which granuloma explants or primary cultures were maintained. Collagenase production was maximal in granulomas obtained from liver of mice 8 weeks postinfection and was inhibited by Actinomycin D or cycloheximide, and enhanced by lymphocyte factor(s) or heparin. Isolated schistosome eggs did not release these enzymatic activities but did release EDTA-insensitive protease activity. Both enzymes were separated by ion-exchange chromatography and purified to homogeneity. Isolated collagenase had an isoelectric point of 6.2 and molecular weight of 60,000 and had the functional characteristics of a tissue collagenase. The specific activity of collagenase was 33 units per mg protein at an optimum pH 7.5 and lacked proteolytic activity against noncollagenous protein substrates. Isolated EDTA-sensitive neutral protease had specific caseinolytic activity of 150 units per mg protein and gelatinolytic activity of 300 units per mg protein at an optimun pH 7.5; the enzyme lacked activity against undenatured collagen. Isoelectric point was pH 6.0. Protease activity was inhibited by known inhibitors of collagenases. Production and activation of EDTA-sensitive neutral protease and collagenase accompany increased collagen synthesis and content in the liver of mice 8 weeks postinfection with S. mansoni cercariae. Continued accumulation of liver collagen under these conditions suggests an insufficiency in collagenase activity relative to the increase in collagen synthesis.
Probing to Bone in Infected Pedal Ulcers
Authors: David A. Nardone
Journal: JAMA (1995)

To the Editor.  —I read with interest the article by Dr Grayson and colleagues. 1 The authors appropriately offered a critique of prior studies, citing retrospective design, small numbers of patients, and lack of diagnostic criteria. However, they failed to discuss the limitations of their study. In an ideal study of contiguous osteomyelitis complicating pedal ulcers, each patient would have undergone both the index test (probing to bone) and the gold standard test (histologic diagnosis). The authors referred for histologic diagnoses only 46 (92%) of 50 patients with a positive probe test and only seven (27%) of 26 patients with a negative probe test. This represents test referral bias 2 whereby patients with a positive index test (probing to bone) are more likely to receive the criterion standard test (histologic diagnosis). As a result, both the true positives and false positives are overrepresented in the study sample. If the clinical
Duration of Esophagogastroduodenoscopy Procedures
Authors: B. Lapeyre
Journal: Endoscopy (2004)

I read with interest the articles by Preiss et al. [1] and Birkner et al. [2] published in the August 2003 issue of Endoscopy, comparing standard peroral, ultrathin peroral, and transnasal esophagogastroduodenoscopy (EGD). The two articles provide comprehensive data and describe adequate methodologies, but ultimately reached different conclusions.
Complete Heart Block Complicating Bacterial Endocarditis
Authors: KYUHYUN WANG, FREDARICK GOBEL, DONALD F. GLEASON, JESSE E. EDWARDS
Journal: Circulation (1972)

Among 142 cases of bacterial endocarditis (BE), complete heart block (CHB) was found in six cases (4%) and first-degree (1°) or second-degree (2°) A-V block in 14 cases (10%). The aortic valve was involved in 18 of 20 cases with atrioventricular (A-V) conduction disturbance, including all six cases of CHB. Anatomic observations (four autopsy, one operative) were made in five of the six cases of CHB. In these cases, a common finding, in addition to involvement of the aortic valve, was extension of the infection to adjacent structures resulting in cardioaortic fistulae. CHB likely resulted from extension of infection to the major conduction tissues. Five of the six patients with CHB died suddenly while in the hospital. One patient was treated with electric pacing while the infection was being controlled and, 38 days later, underwent successful replacement of the aortic valve. Conduction abnormalities are important possible complications of aortic valvular BE. Prompt pacing may be a lifesaving procedure, allowing eradication of infection as a prelude to surgical therapy.
Immunoradiometric measurement of the factor VIII procoagulant antigen.
Authors: J Lazarchick, L W Hoyer
Journal: Journal of Clinical Investigation (1978)

A fluid-phase immunoradiometric assay has been developed which identifies an antigen on the Factor VIII (antihemophilic factor) procoagulant protein. This sensitive and quantitative assay is not influenced by levels of Favor VIII-related antigen (von Willebrand factor) or other plasma proteins. There is a close correlation of procoagulant activity and immunologically detectable protein in normal and von Willebrand's disease plasmas. In contrast, several different patterns have been identified in hemophilic plasmas. Neither procoagulant activity nor procoagulant antigen is detectable in plasmas from patients with severe classic hemophilia. Patients with mild and moderate hemophilia have either comparable plasma concentrations of procoagulant activity and procoagulant antigen or relatively greater levels of immunologically detectable protein.
Peripheral Arterial Embolism
Authors: R. P. Jepson
Journal: BMJ (1955)

Pituitary Crisis.-This may occur as the terminal event in a prolonged pituitary torpor or develop rapidly after a short period of post-operative " decline."The signs of approaching crisis are a rapid deterioration in consciousness, passing into coma; a falling blood pressure which does not respond satisfactorily to intravenous infusions or cardiovascular stimulants; a rapid, thready pulse; and shallow slow respir- ations.The skin becomes cold, and a patchy pallor and cyanosis appear in the lips, cheeks, and extremities.These ominous signs advance rapidly and death occurs in a matter of hours.The serum chemistry in one patient in pituitary crisis (Case 3) was as follows: sodium 288 mg., chloride 540 mg, and potassium 18.2 mg. per 100 ml.; the serum C02 com- bining power was 51 vols.per 100 ml.These figures support the hypothesis that such patients may die in acute or sub- acute adrenocortical failure.Sheehan and Summers (1949) have fully described what they call "hypopituitary coma," occurring in cases of chronic hypopituitarism.There is a great similarity between the state they describe and the torpor and crisis of the surgical cases.Some points of difference-for example, degree of hypoglycaemia, temperature, and pulse rate-may be eliminated by further study.It may be argued that the syndrome is due to frontal-lobe damage at operation, especially in view of the constancy of incontinence as a sign.The recovery of Case 7 from a week's progressive torpor and incontinence, twenty-four hours after instituting hormone therapy, suggests that frontal damage does not play a large part in the syndrome.In short, it seems likely that the syndrome of post- operative pituitary torpor and crisis is the hypopituitary coma of Sheehan and Summers, modified by surgical trauma.
Anthralin oxidation products: role of the C10-methylene and phenol groups
Authors: M. COLIN, J. MAIGNAN, G. LANG, B. SHROOT
Journal: British Journal of Dermatology (1981)

Journal Article Anthralin oxidation products: role of the C10‐methylene and phenol groups Get access M. COLIN, M. COLIN Centre de Recherche de la Société l'Oreal, Groupe de Chimie Générale, 1 Ave. St Germain, 93601 Aulnay sous Bots, et Search for other works by this author on: Oxford Academic Google Scholar J. MAIGNAN, J. MAIGNAN Centre de Recherche de la Société l'Oreal, Groupe de Chimie Générale, 1 Ave. St Germain, 93601 Aulnay sous Bots, et Search for other works by this author on: Oxford Academic Google Scholar G. LANG, G. LANG Centre de Recherche de la Société l'Oreal, Groupe de Chimie Générale, 1 Ave. St Germain, 93601 Aulnay sous Bots, et Search for other works by this author on: Oxford Academic Google Scholar B. SHROOT B. SHROOT Centre International de Recherches Dermatologiques, Sophia Antipolis, 06565 Valbonne Cédex, France Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 105, Issue s20, 1 August 1981, Page 59, https://doi.org/10.1111/j.1365-2133.1981.tb01008.x Published: 01 August 1981
Lack of Transparency in Emergency Care
Authors: Marcus M. Reidenberg
Journal: Annals of Internal Medicine (2013)

LettersDecember 17, 2013Lack of Transparency in Emergency CareMarcus M. Reidenberg, MDMarcus M. Reidenberg, MDFrom Weill Cornell Medical College, New York, New York.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-159-12-201312170-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I read Kocher and Emanuel's article (1) with great interest. The discussions of making medical prices and quality measures public to decrease the cost and increase the quality of medical care assumes that the patient can choose where to get care. Friends, relatives, or first responders usually take acutely ill or injured persons to the nearest emergency department. The patient has no choice. This limitation of transparency as a solution to some of our cost and quality problems should not be ignored.Reference1. Kocher RP and Emanuel EJ. The transparency imperative. Ann Intern Med. 2013;159:296-7 LinkGoogle Scholar Author, Article, and Disclosure InformationAuthors: Marcus M. Reidenberg, MDAffiliations: From Weill Cornell Medical College, New York, New York.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L13-1064. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Transparency Imperative Robert P. Kocher and Ezekiel J. Emanuel Metrics December 17, 2013Volume 159, Issue 12Page: 857KeywordsHealth care quality ePublished: 17 December 2013 Issue Published: December 17, 2013 Copyright & PermissionsCopyright © 2013 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Individual antigen-specific T lymphocytes: helper function in enabling the expression of multiple antibody isotypes.
Authors: S K Pierce, M P Cancro, N R Klinman
Journal: The Journal of Experimental Medicine (1978)

In recent years antigen-specific T cells have been shown to be capable of mediating a number of diverse functions in collaboration with B cells in humoral immune responses. One of the more intriguing roles attributed to helper T cells is the promotion of the synthesis of multiple immunoglobulin isotypes by B cells in T-dependent antibody responses. The experiments presented in this report were carried out to determine if an individual antigen-specific T lymphocyte has the capability to enable the production of antibodies of multiple immunoglobulin heavy chain isotypes. We describe an experimental system which allows for the isolation and antigenic stimulation of individual helper T cells in a splenic environment which provides an excess of primary B cells for collaboration with isolated T lymphocytes. Employing this system we have demonstrated that an individual antigen-specific T lymphocyte, specific for the PR8 strain of influenza virus, has the capacity to enable primary B-cell PR8-specific antibody responses of more than a single immunoglobulin isotype. The implications made by these studies regarding the problem of genetic restrictions regulating T-cell-B-cell interaction is discussed.
Higher-level processes in the formation and application of associations during action understanding
Authors: Lieke Heil, Stan van Pelt, Johan Kwisthout, Iris van Rooij, Harold Bekkering
Journal: Behavioral and Brain Sciences (2014)

Abstract The associative account described in the target article provides a viable explanation for the origin of mirror neurons. We argue here that if mirror neurons develop purely by associative learning, then they cannot by themselves explain intentional action understanding. Higher-level processes seem to be involved in the formation of associations as well as in their application during action understanding.
Competing risks of mortality with marathons: retrospective analysis
Authors: Donald A Redelmeier, J Ari Greenwald
Journal: BMJ (2007)

<b>Objective</b> To determine from a societal perspective the risk of sudden cardiac death associated with running in an organised marathon compared with the risk of dying from a motor vehicle crash that might otherwise have taken place if the roads had not been closed. <b>Design</b> Population based retrospective analysis with linked ecological comparisons of sudden death. <b>Setting</b> Marathons with at least 1000 participants that had two decades of history and were on public roads in the United States, 1975-2004. <b>Main outcome measures</b> Sudden death attributed to cardiac causes or to motor vehicle trauma. <b>Results</b> The marathons provided results for 3 292 268 runners on 750 separate days encompassing about 14 million hours of exercise. There were 26 sudden cardiac deaths observed, equivalent to a rate of 0.8 per 100 000 participants (95% confidence interval 0.5 to 1.1). Because of road closure, an estimated 46 motor vehicle fatalities were prevented, equivalent to a relative risk reduction of 35% (95% confidence interval 17% to 49%). The net reduction in sudden death during marathons amounted to a ratio of about 1.8 crash deaths saved for each case of sudden cardiac death observed (95% confidence interval: 0.7 to 3.8). The net reduction in total deaths could not be explained by re-routing traffic to other regions or days and was consistent across different parts of the country, decades of the century, seasons of the year, days of the week, degree of competition, and course difficulty. <b>Conclusion</b> Organised marathons are not associated with an increase in sudden deaths from a societal perspective, contrary to anecdotal impressions fostered by news media.
Assisted ventilation for chronic neuromuscular disorders
Authors: J D ROAD
Journal: Thorax (2000)

Infection with <i>Burkholderia cepacia</i> due to social contact is well described in patients with cystic fibrosis. However, social transmission to non-cystic fibrosis individuals or chronic colonisation in non-cystic fibrosis individuals has not been described. A report of <i>B cepacia</i> bronchiectasis is presented where a previously healthy mother of two cystic fibrosis children colonised with <i>B cepacia</i> became infected by the same epidemic strain. The implications of this for parents, siblings, and partners of individuals with cystic fibrosis are discussed.