tbuckley/cabot-search huggingface dataset:
Science and art mix creates animal magic
Authors: Balaji Ravichandran
Journal: BMJ (2006)

<h3>Abstract</h3> <h3>BACKGROUND</h3> The aim of this multinational study was to assess the development of adverse mental health symptoms among individuals diagnosed with COVID-19 in the general population by acute infection severity up to 16 months after diagnosis. <h3>METHODS</h3> Participants consisted of 247 249 individuals from seven cohorts across six countries (Denmark, Estonia, Iceland, Norway, Scotland, and Sweden) recruited from April 2020 through August 2021. We used multivariable Poisson regression to contrast symptom-prevalence of depression, anxiety, COVID-19 related distress, and poor sleep quality among individuals with and without a diagnosis of COVID-19 at entry to respective cohorts by time (0-16 months) from diagnosis. We also applied generalised estimating equations (GEE) analysis to test differences in repeated measures of mental health symptoms before and after COVID-19 diagnosis among individuals ever diagnosed with COVID-19 over time. <h3>FINDINGS</h3> A total of 9979 individuals (4%) were diagnosed with COVID-19 during the study period and presented overall with a higher symptom burden of depression (prevalence ratio [PR] 1·18, 95% confidence interval [95% CI] 1·03-1·36) and poorer sleep quality (1·13, 1·03-1·24) but not with higher levels of symptoms of anxiety or COVID-19 related distress compared with individuals without a COVID-19 diagnosis. While the prevalence of depression and COVID-19 related distress attenuated with time, the trajectories varied significantly by COVID-19 acute infection severity. Individuals diagnosed with COVID-19 but never bedridden due to their illness were consistently at lower risks of depression and anxiety (PR 0·83, 95% CI 0·75-0·91 and 0·77, 0·63-0·94, respectively), while patients bedridden for more than 7 days were persistently at higher risks of symptoms of depression and anxiety (PR 1·61, 95% CI 1·27-2·05 and 1·43, 1·26-1·63, respectively) throughout the 16-month study period. <h3>CONCLUSION</h3> Acute infection severity is a key determinant of long-term mental morbidity among COVID-19 patients.
Routine monitoring of all postoperative outcomes at one year: longitudinal study at the Royal National Throat, Nose and Ear Hospital
Authors: R. M Ryan, K. Maduako, C. White, C. A East
Journal: BMJ (1996)

The interest of providers, purchasers, politicians, and patients has focused sharply on outcome analysis in recent years,1 but true “measurement” of outcome can be practised only on small subgroups of patients because of the problems inherent in running randomised controlled trials2 and in interpreting the results of any less formal type of study.3 Simple outcome “monitoring”4 may provide a means of harnessing outcomes data on large groups of patients unsuitable for true outcome measurement. We undertook an intensive study of outcome monitoring to establish whether a useful gauge of subjective outcome could be obtained on the majority of a large heterogenous group of surgical patients after an interval of one year.

From 9 February 1993 to 9 December 1993 all patients being entered on the waiting list for surgery at our hospital were asked by the surgeon in clinic to identify their primary surgical goal, such as “to improve breathing through the nose.” For children (under 16 years) the goal was …
Stability and Inactivation of HTLV-III/LAV Under Clinical and Laboratory Environments
Authors: Lionel Resnick
Journal: JAMA (1986)

The stability of human T-cell lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) under environmental conditions encountered in a clinical or laboratory setting and its inactivation by commonly used chemical disinfectants were investigated. Under our experimental conditions utilizing a highly concentrated viral preparation, virus with an initial infectious titer of approximately 7 log<sub>10</sub>tissue culture infectious dose (TCID<sub>50</sub>) per milliliter can be recovered for more than a week from an aqueous environment held at room temperature (23 to 27 °C) or at 36 to 37 °C. Virus recovery is reduced at a rate of approximately 1 log<sub>10</sub>TCID<sub>50</sub>per 20 minutes when held at 54 to 56 °C. Dried and held at room temperature, HTLV-III/LAV retains infectivity for more than three days with a reduction of approximately 1 log<sub>10</sub>TCID<sub>50</sub>per nine hours. Viral infectivity is undetectable and reduced more than 7 log<sub>10</sub>TCID<sub>50</sub>within one minute with 0.5% sodium hypochlorite, 70% alcohol, or 0.5% nonidet-P40, and within ten minutes with 0.08% quaternary ammonium chloride or with a 1:1 mixture of acetone-alcohol. These results help provide a rational basis to prevent the accidental spread of HTLV-III/LAV in the laboratory or clinical setting. (<i>JAMA</i>1986;255:1887-1891)
Babesiosis in Wisconsin
Authors: Richard W. Steketee
Journal: JAMA (1985)

A confirmed case of human babesiosis was identified in August 1983 in a 54-year-old asplenic Wisconsin resident.<i>Babesia</i>microti was identified as the causative agent by blood smear morphology and hamster inoculation techniques. The patient's wife had clinically confirmed Lyme disease in 1981 and had serologic evidence (immunofluorescent antibody to a<i>B microti</i>titer of 1:1,024) of recent<i>Babesia</i>infection in August 1983. Mice (<i>Peromyscus</i>species) trapped on the patients' property and elsewhere in their Wisconsin county of residence were infected with<i>B microti</i>. Lyme disease and babesiosis have the same tick vector and animal reservoir; serum samples from 116 Wisconsin and Minnesota residents with clinically confirmed Lyme disease between 1980 and 1983 were tested, and none were found to have concurrent<i>Babesia</i>infection. This area of Wisconsin is identified as a new focus for babesiosis transmission, but the risk of transmission seems to be low. (<i>JAMA</i>1985;253:2675-2678)
Reliability testing of the Six Area, Six Sign Atopic Dermatitis severity score
Authors: C.R. Charman, A.J. Venn, H.C. Williams
Journal: British Journal of Dermatology (2002)

Journal Article Reliability testing of the Six Area, Six Sign Atopic Dermatitis severity score Get access C.R. Charman, C.R. Charman Department of Dermatology, Queen's Medical Centre, Nottingham NG7 2UH, U.K Dr Carolyn R. Charman. E‐mail: carolyn.charman@nottingham.ac.uk Search for other works by this author on: Oxford Academic Google Scholar A.J. Venn, A.J. Venn University of Nottingham, Nottingham NG7 2RD, U.K Search for other works by this author on: Oxford Academic Google Scholar H.C. Williams H.C. Williams Department of Dermatology, Queen's Medical Centre, Nottingham NG7 2UH, U.K Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 146, Issue 6, 1 June 2002, Pages 1057–1060, https://doi.org/10.1046/j.1365-2133.2002.04644.x Published: 01 June 2002 Article history Accepted: 21 October 2001 Published: 01 June 2002
Abnormal DNA methylation in T cells from patients with subacute cutaneous lupus erythematosus
Authors: Y. Luo, Y. Li, Y. Su, H. Yin, N. Hu, S. Wang, Q. Lu
Journal: British Journal of Dermatology (2008)

Impaired methylation of T-cell DNA is thought to contribute to the development of systemic lupus erythematosus. However, it is unknown whether T-cell hypomethylation is a factor in other, less severe, forms of lupus erythematosus such as subacute cutaneous lupus erythematosus (SCLE).To investigate global DNA methylation and the expression of genes that regulate methylation in T cells of patients with SCLE.We quantified global methylcytosine levels in CD4+ and CD8+ T cells from 12 patients with SCLE and nine healthy controls. mRNA levels of DNA methyltransferases (DNMTs), methylated CpG binding proteins (MBDs) and CD11a were measured by real-time quantitative polymerase chain reaction.CD4+ T-cell DNA from patients with SCLE was hypomethylated relative to controls (P = 0.002). DNMT1 and DNMT3a mRNA levels were significantly lower in CD4+ T cells from SCLE patients than in controls (P = 0.027 and P = 0.004, respectively). Relative to controls, MBD1, MBD3 and MBD4 mRNA levels were significantly higher in SCLE CD4+ cells (P < 0.001, P < 0.001 and P = 0.001, respectively), whereas MECP2 and MBD4 mRNA expression were significantly increased in SCLE CD8+ T cells (P = 0.001 and P = 0.001, respectively). DNMT1 expression positively correlated with CD4+ T-cell DNA methylation within our SCLE patient cohort (r = 0.590, P = 0.044). CD11a mRNA expression was significantly increased in SCLE CD4+ T cells relative to controls (P = 0.044) and negatively correlated with DNA methylation (r = -0.669, P = 0.049).These data suggest that aberrant regulation of DNA methylation in CD4+ T cells is associated with the development of SCLE.
Psychosocial Adjustment to Advanced Proliferative Diabetic Retinopathy
Authors: Lawson R Wulsin, Alan M Jacobson, Lawrence I Rand
Journal: Diabetes Care (1993)

OBJECTIVE To identify the major problems with adjustment to the advanced stages of proliferative diabetic retinopathy and to examine the relationship between adjustment and visual acuity. RESEARCH DESIGN AND METHODS A cross-sectional descriptive cohort study was conducted at the referral-based eye unit at Joslin Diabetes Center in Boston, Massachusetts. We studied 47 adults with IDDM and advanced proliferative diabetic retinopathy. Thirty reported recent visual loss, and 17 had more stable vision. RESULTS Psychosocial Adjustment to Illness Scale scores were significantly elevated relative to a normative diabetic sample (t = 2.94, P &amp;lt; 0.01). Our proliferative diabetic retinopathy sample reported the most difficulties in the domain of health-care orientation. No significant differences were observed in adjustment scores between those with recent partial visual loss and those with more stable vision. However, visual acuity in the best eye correlated significantly with the proliferative diabetic retinopathy sample's total adjustment score (r = −0.34, P = 0.02) and with 4 of 7 adjustment subscales. CONCLUSIONS These results suggest that advanced proliferative diabetic retinopathy may be associated with particular difficulties in adjustment that are more related to best visual acuity than to recent visual loss. Relatively mild visual impairment may have significant psychosocial impact.
Gout and Salt-Wasting Renal Disease During Pregnancy
Authors: Ronald E. Batt, William J. Cirksena, Thomas B. Lebherz
Journal: JAMA (1963)

A case study was made of a pregnant woman with gout. Azotemia was a complication as it was in three of four similar cases. It was found that the azotemia in our patient was aggravated by salt-wasting renal disease which was successfully treated by adequate salt replacement. Toxemia of pregnancy developed and labor was induced when medical therapy failed. The characteristic postpartum exacerbations of gouty arthritis were prevented by maintenance of renal function and by administration of colchicine.
1130-220 Brugada-type electrocardiographic pattern and ST-segment alternans in right precordial leads during percutaneous coronary intervention of the proximal right coronary artery
Authors: Naoki Fujimoto, Chikaya Omichi, Takafumi Koji, Atsushi Kawasaki, Shigeki Kato, Atsunobu Kasai
Journal: Journal of the American College of Cardiology (2004)
Tertiary educational assessment with mean individual level knowledge.
Authors: C A Shanks, J D Paull
Journal: BMJ (1981)

It is proposed that Tertiary Educational Assessment should be made using a Curve-Unifying Paradigm with its Scientific And Ultra-Conservative Experiment Ratio. Central Ranking Evaluation And Marking was used to process examination results, generating the Mean Individual Level Knowledge for the group. The concept of MILK grew from the need to encourage the average examination candidate and with it came the need for a Judgmental Understanding Goal. The results of some candidates required further handling by the addition of Student's Universal Grade Averaging Regimen.
Disruption of Src function potentiates Chk1-inhibitor–induced apoptosis in human multiple myeloma cells in vitro and in vivo
Authors: Yun Dai, Shuang Chen, Rena Shah, Xin-Yan Pei, Li Wang, Jorge A. Almenara, Lora B. Kramer, Paul Dent, Steven Grant
Journal: Blood (2010)
Thomas James Kitson Merritt
Authors: J. Howells
Journal: BMJ (2002)

Former consultant psychiatrist Ipswich Hospital (b Cornwall 1928; q London 1952), died from acute left ventricular failure on 17 February 2002.

His consultant career was exclusively at the Institute of Family Psychiatry, Ipswich Hospital, where he was a psychotherapist in the mould of experiential psychopathology. Jim Merritt also had meritorious non-medical accomplishments. He sang, played the organ, was an ardent amateur astronomer, and in his retirement became a considerable artist, excelling in landscape. He leaves a wife, Vera; three children; and five grandchildren.
Metabolic profiling of heat or anoxic stress in mouse C2C12 myotubes using multinuclear magnetic resonance spectroscopy
Authors: Ida K. Straadt, Jette F. Young, Bent O. Petersen, Jens Ø. Duus, Niels Gregersen, Peter Bross, Niels Oksbjerg, Hanne C. Bertram
Journal: Metabolism (2009)
RESULT OF A TRIAL FOR EVALUATING ADDITIONAL BENEFIT OF CILOSTAZOL TO DUAL ANTIPLATELET THERAPY IN PATIENTS WITH LONG OR MULTIVESSEL CORONARY ARTERY DISEASE UNDERWENT BIOLIMUS–ELUTING STENT IMPLANTATION (ABCD TRIAL)
Authors: Young Jin Youn, Jun–Won Lee, Sung Gyun Ahn, Seung–Hwan Lee, Junghan Yoon, Bong Ki Lee, Byung Ok Kim, Cheol Woong Yu, Dong Woon Jeon, Hyuck Moon Kwon, Hyun Min Choe, Jang Hyun Cho, Keum Soo Park, Kook Jin Chun, Kyoo Rok Han, Kyung Soo Kim, Myeong Kon Kim, Myung Ki Hong, Sang Yong Yoo, Seung Woon Rha, Young Joon Hong, Yun Hyeong Cho
Journal: Journal of the American College of Cardiology (2013)
Case of a Polypus becoming Sphacelated while within the Cavity of the Uterus: Removal: Recovery
Authors: T. Sympson
Journal: BMJ (1874)

17Ireferred to.The attempt was in both cases probably justifiable, since the disease was otherwise incurable; but the proposal is not one which holds out any strong prospect of practical utility, particularly in popli- teal aneurism.Some cases were theni spokeni of (anld illustrated by preparations from the Hunterian and otlher Museums) in which, after the consolidation of a popliteal aneurism, gangrene has taken place, and amputation become necessary.In many of these cases the diagnosis has been erroneous, and in all probability necessarily so, as
Heart Failure and Ventricular Dysfunction in Patients With Single or Systemic Right Ventricles
Authors: Sanaz Piran, Gruschen Veldtman, Samuel Siu, Gary D. Webb, Peter P. Liu
Journal: Circulation (2002)

Background — Previous studies suggested a high incidence of congestive heart failure in patients with single and/or systemic right ventricles. The corresponding risk in an adult population is unknown. Methods and Results — A cohort of 188 consecutive adult patients with single or systemic right ventricles was prospectively assessed with gated radionuclide angiography (n=135) or 2D echocardiography (n=188) and followed up clinically. Clinical assessment showed 82.4% of the patients were in New York Heart Association class I or II, 13.3% were in class III, and 4.3% were in class IV. Heart failure occurred in 22.2% of patients with transposition of the great arteries and a Mustard procedure, 32.3% of patients with congenitally corrected transposition of the great arteries, and 40% of Fontan-palliated patients. Symptomatic patients had significantly lower anaerobic thresholds (10.3±2.8 versus 13.2±4.8 mL · kg −1 · min −1 , P =0.006) and peak · V o 2 (15.2±4.8 versus 20.3±6.8 mL · kg −1 · min −1 , P &lt;0.00029). Systemic ventricular ejection fraction in symptomatic versus asymptomatic patients at rest was 34.8±15.7% versus 46.7±13.4% ( P =0.00001). Mortality was 47.1% among symptomatic patients and 5% among asymptomatic patients at 15.7 years of postoperative follow-up. Seven of 12 patients with potentially correctable surgical lesions died or persisted in heart failure despite surgery. Best predictors for mortality were New York Heart Association class, systemic ejection fraction, and age at operation. Conclusions — Patients with single or systemic right ventricles have significant risk for heart failure accompanied by high mortality. This study suggests the importance of identifying this group of patients who are at risk for heart failure and considering strategies to preserve ventricular function.
The Acyclic CB1R Inverse Agonist Taranabant Mediates Weight Loss by Increasing Energy Expenditure and Decreasing Caloric Intake
Authors: Carol Addy, Hamish Wright, Koen Van Laere, Ira Gantz, Ngozi Erondu, Bret J. Musser, Kaifeng Lu, Jinyu Yuan, Sandra M. Sanabria-Bohórquez, Aubrey Stoch, Cathy Stevens, Tung M. Fong, Inge De Lepeleire, Caroline Cilissen, Josee Cote, Kim Rosko, Isaias N. Gendrano, Allison Martin Nguyen, Barry Gumbiner, Paul Rothenberg, Jan de Hoon, Guy Bormans, Marleen Depré, Wai-si Eng, Eric Ravussin, Samuel Klein, John Blundell, Gary A. Herman, H. Donald Burns, Richard J. Hargreaves, John Wagner, Keith Gottesdiener, John M. Amatruda, Steven B. Heymsfield
Journal: Cell Metabolism (2008)
The Health Care of Hispanics-Reply
Authors: Eric Muñoz
Journal: JAMA (1991)

In Reply. —  We compliment Dr Manson on his work stressing   between Spanish-speaking patients and their physicians, and we agree that  is a need for greater language concordance among American health care providers.  However, we would like to point out that in our editorial we wrote there are many hypotheses but little consensus regarding health care utilization by Hispanics, not, as Dr Manson says,  'there are many hypotheses but little consensus' as to whether increasing the number of Hispanic physicians will improve health care utilization for Spanish-speaking patients. The two sentences have different meanings.  Dr Manson notes that increasing the number of Hispanic physicians would improve the provision of health care for Hispanics. We have no doubt that if  were substantial increases in Hispanic physicians in the United States, assuming that the large majority of them could speak Spanish and they practiced in areas where the
Misunderstanding From Diction
Authors: Jean Spencer Felton
Journal: JAMA (1980)

To the Editor.—  In recent interchanges with several attorneys wherein various x-ray films were involved, an interesting difference in understanding emerged.  On receiving a report of a radiological study, or on hearing of the interpretation of the films by a radiologist during a deposition or the giving of testimony, certain of the attorneys expressed their belief that the term negative, commonly used by physicians as a succinct conclusion following a review of the examination results, actually meant positive. Negative was viewed in the sense of being wrong, or bad, or unusual, or abnormal. Positive bore the meaning of good or normal,  connoting the medical understanding of not demonstrating or proving the presence or existence of symptoms, bacteria, etc. 1   Such antithetical understanding can, and does, prove difficult and leads to unnecessary clarification. It is suggested that the use of negative and positive be abandoned in this sense and that
A Novel Maneuver for Colonic Polypectomy at the 6-o’Clock Position
Authors: S. Ladas, C. Tzathas, D. Polymeros, T. Emmanuel, K. Triantafyllou
Journal: Endoscopy (2006)

For effective colonic polypectomy, the polyp has to be positioned in the 5 - 7-o’clock position in the field of view. This has traditionally been achieved by changing the patient’s position or by twisting the shaft of the scope, or both [1]. However, rotating a heavily sedated patient is not easy, and twisting the scope exerts a force on the shaft, the position of which has to be maintained by continually applying torque.
Corrigendum to: Cardioversion of persistent atrial fibrillation by a combination of atrial specific and non-specific class III drugs in the goat [Cardiovascular Research 75 (2007) 89–98]
Authors: Y BLAAUW, U SCHOTTEN, A VANHUNNIK, H NEUBERGER, M ALLESSIE
Journal: Cardiovascular Research (2007)

1, 3 and 10 μg/kg/h.
UK sees small decrease in TB, but incidence is still high
Authors: J. Wise
Journal: BMJ (2014)

The number of new cases of tuberculosis has fallen slightly in the United Kingdom, but public health officials warn against complacency, as the incidence remains high relative to most other western European countries.

Last year 7892 cases of tuberculosis were notified in the UK, down from 8729 in 2012, the latest figures from Public Health England have shown.1 The UK’s incidence rose from the early 1980s until the mid-2000s and have been at a high but relatively stable level …
Testosterone Therapy Boosts MI Risk
Authors: Anita Slomski
Journal: JAMA (2014)

Men treated with testosterone therapy (TT) are at substantially increased risk of acute nonfatal myocardial infarction (MI), concluded authors of a cohort study of 55 593 men (Finkle W et al. PLoS One. doi:10.1371/journal.pone.0085805 [published online January 29, 2014]).
Attitudes Toward Adolescents on Adult Wards of a Mental Hospital
Authors: BETTY ANN GLASSER, ERNEST L. HARTMANN, NICHOLAS C. AVERY
Journal: American Journal of Psychiatry (1967)

Mixing adult and adolescent patients is the trend on the ward level in psychiatric hospital treatment of adolescents. The authors examine the attitudes of the three groups closest to 55 hospitalized adolescents—the hospital staff, the adult patients, and the parents of the adolescent patients. The results of this study indicate considerable underlying hostility on the part of each group toward the mixing of adolescents and adults in wards. The authors suggest the importance of bringing such attitudes to light.
Biomarkers and Cardiovascular Disease
Authors: Svati H. Shah, James A. de Lemos
Journal: JAMA (2009)

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