tbuckley/cabot-search huggingface dataset:
Concussion among Swedish elite ice hockey players.
Authors: Y Tegner, R Lorentzon
Journal: British Journal of Sports Medicine (1996)

To evaluate the frequency of concussion in Swedish ice hockey and to establish a uniform grading and treatment model for concussions of different severity.Frequency of concussion was investigated in two studies, one retrospective and one prospective. In the retrospective study, all Swedish elite ice hockey players (n = 265) were asked to answer a questionnaire on the number and treatment of previous concussions. Only concussions diagnosed by a doctor were recorded. The questionnaire was completed by 227 players (86%). In the prospective study, all injuries including concussions occurring during game and practice in the Swedish Elite League (n = 12 teams) were recorded during four years. The causes of injury, referees judgements, diagnosis, treatment, and time absent from ice hockey were registered on special cards.In the retrospective study, 51 out of 227 players (22%) in the Swedish Elite League reported at least one concussion. In the prospective study, 52 concussions were reported. The incidence of a concussion is at least one concussion every year/team or a yearly risk of about 5% for a player to sustain a concussion. Most concussions occurred during league play (81%). Body contact (checking or boarding) was the most common cause of concussions. The players were absent from full training and play on a mean of 6 d.As this injury is potentially dangerous it must be treated seriously according to a simple treatment model presented. In cases of repeated concussions during the same season, a longer period of time away from play is suggested. In players who have sustained several concussions over the years a thorough medical examination including EEG, CT/MRI, and neuropsychological tests should be performed. If any of these is pathological the player should be advised to give up ice hockey.
Congenital Combined Deficiency of Coagulation Factors II, VII, IX and X
Authors: Campbell W. McMillan, Harold R. Roberts
Journal: New England Journal of Medicine (1966)

PLASMA activities of coagulation factors II (prothrombin), VII (proconvertin), IX (Christmas factor) and X (Stuart factor) have in common 3 generally recognized characteristics: these activities are depressed to a mutual degree in vitamin K deficiency acquired by impaired gastrointestinal absorption or coumarin therapy and also in hepatic dysfunction; they are presumably derived from undefined functions of vitamin K and functionally intact hepatic cells; and they are preferentially adsorbed onto barium sulfate and certain related compounds. In view of the clinical and biochemical relation of these 4 coagulation factors, the term "prothrombin complex" has been applied to them.1 Isolated deficiency of . . .
P191 Development of a new patient reported experience measure for the improving lung cancer outcomes project
Authors: S. Christie, N. Bell, T. Malinowski, A. Roberts, I. Woolhouse
Journal: Thorax (2010)

<h3>Background</h3> Lung cancer survival rates are poor and the vast majority of patients receive palliative treatment only. Assessment of the patient experience is extremely important in this group, however relatively little is currently known in this area. For the first time at a national level the Improving Lung Cancer Outcomes Project (ILCOP) will collect patient reported experience data using a tool designed specifically for lung cancer patients. We describe the development of this measure, in particular the key areas of the patient experience as identified by lung cancer patients and carers. <h3>Methods</h3> The views of a wide range of lung cancer patients and carers on their healthcare experience from diagnosis through to treatment were obtained by the Roy Castle Lung Cancer Foundation and the National Lung Cancer Forum for Nurses via telephone interviews, email and postal questionnaires, and a targeted focus group. Key themes were identified and mapped to previously validated questions from the national cancer survey (with permission of Picker Institute). Macmillan Cancer Support advised on questionnaire design and the final version was tested by a further group of patients. <h3>Results</h3> The key areas of the patient experience were reported as communication, privacy, respect and dignity, support for emotional and physical symptoms, and information. These domains were mapped to 12 multiple choice type questions from the national cancer survey. Two free text questions relating to areas of good practice and areas for improvement were added. Testing demonstrated that the questionnaire was straightforward, easy to understand and covered the areas that were most important to patients and carers. The six questionnaires sent out in the pilot phase were completed appropriately and returned the correct address. <h3>Conclusions</h3> We have identified the key areas of the patient experience for a wide range of lung cancer patients and carers which we have successfully incorporated into a new lung cancer patient reported experience measure. In addition to guiding quality improvement work in the national ILCOP, this questionnaire could be used by local lung cancer teams to assess the patient experience at trust level.
Mating and marriage, husbands and lovers
Authors: Stephen Beckerman
Journal: Behavioral and Brain Sciences (2000)

Human mating strategies are contingent on individual prospects. Gangestad &amp; Simpson provide a useful framework to explore these differing prospects, but do not take sufficient account of what is known ethnographically about mating decisions. Women often do not select their own long term mates. Men often have two or more long term mates, and can invest in the offspring of short term matings also.
Laugh If This Is a Joke
Authors: Lars Ljungdahl
Journal: JAMA (1989)

<h3>To the Editor. —</h3> Research findings are beginning to accumulate that suggest humor and laughter might be therapeutic and could be used to reduce disease symptoms.<sup>1</sup>Applications have been developed already, for example, humorrooms in hospitals. Since clinical evaluations still seem to be lacking, the present report of a first attempt at implementing humor therapy in general practice might be warranted. <h3>Study.—</h3> Eight consecutive outpatients suitable for the therapy were selected. Six agreed to participate: all were women aged 26 to 48 years, with painful musculoskeletal disorders and depressive moods but no severe psychiatric conditions. Together with a staff of one male and two female nurses we formed a "humor-group," which met 13 times at our primary health care center. The atmosphere was relaxed and jolly during meetings—discussion of problems, symptoms, and disease was avoided. We used funny books, records, and videofilms and learned to give higher priority to
Pharmacokinetics of Pamidronate in Patients With Bone Metastases
Authors: S. Leyvraz, U. Hess, G. Flesch, J. Bauer, S. Hauffe, J. M. Ford, P. Burckhardt
Journal: JNCI Journal of the National Cancer Institute (1992)

Background : Pamidronate is a secondgeneration bisphosphonate used in the treatment of tumor-induced hypercalcemia and in the management of bone metastases from breast cancer, myeloma, or prostate cancer. The pharmacokinetics of pamidronate is unknown in cancer patients. Purpose : To determine the influence of the rate of administration and of bone metabolism, we studied the pharmacokinetics of pamidronate at three different infusion rates in 37 patients with bone metastases. Methods : Three groups of 11–14 patients were given 60 mg pamidronate as an intravenous infusion over a period of 1, 4, or 24 hours. Urine samples were collected in the three groups of patients. Plasma samples were obtained only in the 1-hour infusion group. The assay of pamidronate in plasma and urine was performed by high-performance liquid chromatography with fluorescence detection after the derivatization of pamidronate with fluorescamine. Results : The body retention (BR) at 0–24 hours of pamidronate represented 60%–70% of the administered dose and was not significantly modified by the infusion rate. In particular, the BR at 0–24 hours was not reduced at the fastest infusion rate. Among patients, a threefold variability in BR at 0–24 hours occurred, which was related directly to the number of bone metastases and, to some extent, to creatinine clearance. At 60 mg/hour, the plasma kinetics followed a multiexponential course characterized by a short distribution phase. The mean (±SD) half-life of the distribution phase was 0.8 hour (±0.3), the mean (±SD) of the area under the curve for drug concentration in plasma × time at 0-24 hours was 22.0 × 8.8 μmol/L × hours, and the mean (±SD) of the maximum plasma concentration was 9.7 μmol/L (±3.2). Pharmacokinetic variables remained unchanged after repeated infusions applied to four patients. Clinically, the three infusion rates were equally well tolerated without significant toxicity. Conclusions : The 1-hour infusion rate could be proposed as kinetically appropriate for the administration of pamidronate to patients with metastatic bone diseases. [J Natl Cancer Inst 84: 788–792, 1992]
Trouble in paradise--learning from Hawaii
Authors: S. Teasdale
Journal: BMJ (2005)

Roles, responsibilities, and relationships of clinical staff-During the early stages of implementation, changes in clinicians' productivity may require extra staff and the ability to make continuous adjustments.As the organisation adapts to the new electronic system, the capability is needed to document what care a patient received, who provided it and when, so processes may need to adapt to revised professional and legal standards. Limitations of studyOur study captures only a snapshot view, during a volatile phase of implementation and transition from one electronic medical record system to another.The respondents' perceptions should be seen in this context.In fact, another Kaiser Permanente region had implemented an earlier CIS version successfully.However, our overall findings highlight issues likely to be faced by organisations implementing or modifying an electronic medical record system.
Simple Method for Passage of Small-Bore Nasogastric Feeding Catheter
Authors: DANIEL E. GREMILLION
Journal: Annals of Internal Medicine (1979)

Letters1 October 1979Simple Method for Passage of Small-Bore Nasogastric Feeding CatheterDANIEL E. GREMILLION JR.DANIEL E. GREMILLION JR.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-91-4-655_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Enteral hyperalimentation has been found to be a valuable adjunct in the treatment of various illnesses (1-4). The soft small-bore nasogastric feeding catheter is especially advantageous for long-term use, but its flexibility can make passing the tube into the stomach or proximal intestine difficult, especially in patients with esophageal strictures, neuromuscular causes of esophageal dysphagia, or esophageal dysmotility.I have devised a method for passage of a small-bore nasogastric enteral feeding catheter that is simple, effective, comfortable for the patient, and does not require use of a gelatin capsule as described by Kaminski (5) or an upper...References1. HEYMSFIELDBETHELANSLEYNIXONRUDMAN SRJDD. Enteral hyperalimentation: an alternative to central venous hyperalimentation. Ann Intern Med. 1979;90:63-71. LinkGoogle Scholar2. DOBBIEHOFFMEISTER RJ. Continuous pump-tube enteric hyperalimentation. Surg Gynecol Obstet. 1976;143:273-6. MedlineGoogle Scholar3. PAGERYANHAFF CJR. Continual catheter administration of an elemental diet. Surg Gynecol Obstet. 1976;142:184-8. MedlineGoogle Scholar4. SHILS M. Enteral nutrition by tube. Cancer Res. 1977;37:2432-9. MedlineGoogle Scholar5. KAMINSKI M. Enteral hyperalimentation. Surg Gynecol Obstet. 1976;143:12-6. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DANIEL E. GREMILLIONJR.Affiliations: MC USA 322 22nd Avenue North; Nashville, TN 37203 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPassing a Small-Bore Nasogastric Feeding CatheterDARRELL S. RIGEL, M.D., CLIFFORD SAPER, M.D. 1 October 1979Volume 91, Issue 4Page: 655-656KeywordsCathetersDysphagiaStomach ePublished: 1 December 2008 Issue Published: 1 October 1979 PDF downloadLoading ...
Lupeol targets liver tumor-initiating cells through phosphatase and tensin homolog modulation
Authors: Terence Kin Wah Lee, Antonia Castilho, Vincent Chi Ho Cheung, Kwan Ho Tang, Stephanie Ma, Irene Oi Lin Ng
Journal: Hepatology (2010)

Liver tumor-initiating cells (T-ICs) are capable of self-renewal and tumor initiation and are more chemoresistant to chemotherapeutic drugs. The current therapeutic strategies for targeting stem cell self-renewal pathways therefore represent rational approaches for cancer prevention and treatment. In the present study, we found that Lup-20(29)-en-3β-ol (lupeol), a triterpene found in fruits and vegetables, inhibited the self-renewal ability of liver T-ICs present in both hepatocellular carcinoma (HCC) cell lines and clinical HCC samples, as reflected by hepatosphere formation. Furthermore, lupeol inhibited in vivo tumorigenicity in nude mice and down-regulated CD133 expression, which was previously shown to be a T-IC marker for HCC. In addition, lupeol sensitized HCC cells to chemotherapeutic agents through the phosphatase and tensin homolog (PTEN)–Akt–ABCG2 pathway. PTEN plays a crucial role in the self-renewal and chemoresistance of liver T-ICs; down-regulation of PTEN by a lentiviral-based approach reversed the effect of lupeol on liver T-ICs. Using an in vivo chemoresistant HCC tumor model, lupeol dramatically decreased the tumor volumes of MHCC-LM3 HCC cell line-derived xenografts, and the effect was equivalent to that of combined cisplatin and doxorubicin treatment. Lupeol exerted a synergistic effect without any adverse effects on body weight when combined with chemotherapeutic drugs. Conclusion: Our results suggest that lupeol may be an effective dietary phytochemical that targets liver T-ICs. (Hepatology 2011.)
Treatment of Snakebite
Authors: Maynard F. Ewton
Journal: JAMA (1976)

To the Editor.—  Dr Thomas Glass' article on the early debridement of pit viper bites (235:2513, 1976) we believed was excellent in its content and clarity, and was most helpful in correcting some earlier widespread misconceptions regarding treatment. We were disappointed, however, in his wide-reaching allegation that recommendations made by physicians for nonmedical first aid were for the purpose of having someone to blame in case of treatment failure.
THE ALBUMINURIA OF PREGNANCY TREATED BY THE INTERNAL ADMINISTRATION OF CHLOROFORM.—REPORT OF CASES.Read in the Section of Obstetrics and Diseases of Women, at the forty- third Annual Meeting of the American Medical Association, held at Detroit, June, 1892.
Authors: JOHN MILTON DUFF
Journal: JAMA (1892)

In the<i>Southern Medical Journal</i>for August, 1890, an article appeared from the pen of Dr. A. W. Griggs, claiming excellent results in the treatment of the "Albuminuria of Pregnancy" by the internal administration of "chloroform" in from ten to twenty drop doses in water after each meal and at midnight. Inasmuch as my own treatment of this condition had not been altogether satisfactory, I determined to give chloroform a trial as soon as an opportunity offered. As a result of my trial of the remedy I append cases representative of different cases coming under my own observation and that of some of my medical friends. Case 1.—On November 3, 1890, my first opportunity offered in the person of Miss C, unmarried, æt. 22 years ; pregnant about 8 months. Two weeks ago her feet and ankles began to swell and the swelling has gradually increased until today she has
Simvastatin seems unlikely to cause impotence
Authors: T. R Pedersen, O. Fargeman
Journal: BMJ (1999)

Laparoscopic versus open mesh repair of inguinal hernia For most patients hernias provoke minimal symptomsEditor-In Wellwood et al's trial of laparoscopic hernia repair versus open mesh repair only patients fit for general anaesthesia were preselected. 1 We do not know if the rejected patients were suitable for local anaesthesia, which is usually ideal for frail and elderly patients and those with high American Society of Anesthesiologists grades.The type of anaesthesia used greatly affects morbidity associated with elective hernia repair. 2 As the authors report, after laparoscopic repair with general anaesthesia, patients may have postoperative nausea, vomiting, and retention of urine.Disorientation and cognitive dysfunction may occur with elderly patients after general anaesthesia but are rare after local anaesthesia.In Wellwood et al's trial postoperative discomfort after laparoscopic repair was reduced slightly, but does it matter?Assessment of postoperative pain is difficult, but elderly patients commonly experience less pain and require less analgesia than young adults after open hernia repair.This might be attributed to the loss of neurones with ageing 3 combined with the decrease in muscle bulk.Although laparoscopic repair is more expensive, many people have suggested that there are economic benefits of early return to work.In reality this is not so: patients over 60 are unlikely to be engaged in the labour market, so there is minimal benefit.For elderly patients, who represent half of most series, whether laparoscopic repair offers any benefits at all remains to be proved.Even with rapid recovery most employees expect a traditional amount of time off, whereas self employed patients tend to return to work as soon as possible despite any slight discomfort.The ability and desire to return to work are subjective and greatly influenced by personal circumstances.Laparoscopic repair is a more complex invasive procedure, and catastrophic complications may occur 4 ; these are unheard of with open repair.In a statistical sense the non-occurrence of an adverse event in a surgical series, as reported in this trial, does not mean that it cannot happen.Major complications from the pneumoperitoneum, bowel and vascular perforation, and acute and delayed intestinal obstruction do occur.For most patients a hernia is a benign lump that provokes minimal symptoms.Why expose patients to the major risks of a laparoscopic approach when there are marginal differences in outcome compared with open mesh repair under local anaesthesia, especially when open mesh repair is technically simple, is easily learnt, has consistent results, and is safer and cost effective?
SOME OBSERVATIONS AND EXPERIENCE IN THE TREATMENT OF EPILEPSY ACCORDING TO THE METHOD SUGGESTED BY DR. FELIX VON NIEMEYER.
Authors: MATTHEW WOODS
Journal: JAMA (1897)

So much has been said and done within the past few years in attempted elucidation and cure of that complex series of phenomena commonly known as epilepsy or "fits," that the preparation of another paper on the subject might be deemed an impertinence, but for the fact that the disease and its treatment, judging from printed current opinion on the matter, is still as much of a problem as it was twenty years ago, and that the treatment I am about to elucidate produces better results than that of any treatment with which I am acquainted. It is not the intention of this paper, nor is it at all necessary to my purpose to discuss the cause and nature of the disease—a sort of "Pigrogromitus of the Vapians" among diseases, no one seeming to know who or what they were—so of epilepsy. The old theories are familiar enough, yet so
The GMC: expediency before principle
Authors: Justin A B Robbins
Journal: BMJ (2005)

Editor—Isn't it now time that we as doctors acknowledged that professional self regulation is a contradiction in terms?1 Do we trust any other professionals to self regulate—for example, lawyers, politicians, the police? I think not, so why should any layperson trust us in this regard?

If we had the humility and courage to say this publicly we would gain more in public respect than we would lose in self esteem.
Thyroid and Parathyroid Lesions After Radiation
Authors: EDWIN M. KNIGHTS
Journal: Annals of Internal Medicine (1978)

Letters and Corrections1 November 1978Thyroid and Parathyroid Lesions After RadiationEDWIN M. KNIGHTS, M.D., F.A.C.P., F.A.S.C.P., EDUARDO PHILLIPS, M.D., F.A.C.S.EDWIN M. KNIGHTS, M.D., F.A.C.P., F.A.S.C.P.Search for more papers by this author, EDUARDO PHILLIPS, M.D., F.A.C.S.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-89-5-725_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Tony Christensson's report (Ann Intern Med 89:216-217, 1978) on the possible relation between hyperparathyroidism and previous neck irradiation is timely. It is becoming increasingly apparent that parathyroid abnormalities, as well as thyroid carcinoma, can be a sequel to such irradiation. They may occur simultaneously, as illustrated by a case we recently encountered.A 53-year-old housewife was found on routine examination to have a mass about 0.2 cm. in diameter on the anterior right side of her neck. A 1-cm mass was also felt in the left lobe of the thyroid. Both moved upward with swallowing and were...References1. ELLENBERG A, GOLDMAN L, GORDAN G, and LINDSAY S: Thyroid carcinoma in patients with hyperparathyroidism. Surgery 51:708-717, 1962 MedlineGoogle Scholar2. SCHACHNER S and HALL A: Parathyroid adenoma and previous head-and-neck irradiation. Ann Intern Med 88:804, 1978 LinkGoogle Scholar3. TRIGGS S and WILLIAMS E: Irradiation of the thyroid as a cause of parathyroid adenoma (letter). Lancet 1:593-594, 1977 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: EDWIN M. KNIGHTS, M.D., F.A.C.P., F.A.S.C.P.; EDUARDO PHILLIPS, M.D., F.A.C.S.Affiliations: South Macomb Hospital Warren, MI 48093 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHYPERPARATHYROIDISM DUE TO A CYSTIC PARATHYROID ADENOMA AFTER IRRADIATION OF THE NECKAssociation between primary hyperparathyroidism and previous irradiationUnexpected parathyroid disease discovered at thyroidectomy in irradiated patients 1 November 1978Volume 89, Issue 5_Part_1Page: 725-726KeywordsHyperparathyroidismLesionsParathyroidSwallowingThyroidThyroid carcinoma ePublished: 1 December 2008 Issue Published: 1 November 1978 PDF downloadLoading ...
Intracellular peptides of natriuretic peptide receptor-C inhibit vascular hypertrophy via Gqα/MAP kinase signaling pathways☆
Authors: Y LI, S HASHIM, M ANANDSRIVASTAVA
Journal: Cardiovascular Research (2006)

Objective: The present studies were undertaken to investigate if the activation of natriuretic peptide receptor-C (NPR-C) that has been shown to inhibit cell proliferation could also modulate the hypertrophic responses of vasoactive peptides in A10 vascular smooth muscle cells (VSMC).
Cow's milk–specific T-cell reactivity of children with and without persistent cow's milk allergy: Key role for IL-10
Authors: Machteld M. Tiemessen, Adrie G. Van Ieperen-Van Dijk, Carla A.F.M. Bruijnzeel-Koomen, Johan Garssen, Edward F. Knol, Els Van Hoffen
Journal: Journal of Allergy and Clinical Immunology (2004)