tbuckley/cabot-search huggingface dataset:
Facteurs prédictifs d'exérèse complète, de morbidité et suivi à long terme après exérèse endoscopique des polypes coliques de grande taille
Authors: A Geagea, G Rahmi, T Lecomte, G Malamut, T Maniere, L Martin, F Bloch, B Boboc, B Landi, JM Canard, R Jian, C Cellier
Journal: Endoscopy (2008)

Objectif: Evaluer la faisabilité, la morbidité de la résection endoscopique (RE) des polypes coliques (PC) en fonction du siège, de la taille et de la technique endoscopique utilisée et rechercher les facteurs prédictifs de récidive locale.
THREE PHASE BONE SCAN (TPBS) FOLLOWING POROUS COATED HIP ARTHROPLASTY (PCHA)
Authors: S G Oswald, D Van Nostrand, J J Callaghan, C G Savory, S H Abreu
Journal: Clinical Nuclear Medicine (1988)

Twenty-five uncomplicated PCHA in 21 patients were prospectively studied with serial TPBS at approximately 7 days, and 3, 6, 12, 18, and 24 months (mos) postoperatively. The medial (MS), distal (DS), and lateral (LS) segments of the tip were evaluated for intensity of uptake on flow, blood pool, and bone images (grade O = background, 1+ < iliac crest, 2+ = iliac crest, 3+ > iliac crest). The flow and blood pool reference was contralateral iliac vein. On flow 135/136 scans had grade O activity. On blood pool 131/136 scans had grade O activity. Of the extensive bone scan data, which will be presented, several patterns were identified: 1. The MS had stable or decreasing activity from 3 to 24 mos in (23/25) PCHA; 2. No patient had MS activity of 3+ from 12 to 24 mos; 3. The MS was always less than or equal to LS from 3 to 24 mos; 4. The LS had increasing activity during at least one interval in (12/25) PCHA; 5. The LS was 2+ or 3+ at 24 mos in 8/25 PCHA; 6. Activity “migrated” from MS to DS to LS in 7/25 PCHA; 7. No dominant pattern was noted in the DS. In conclusion, this study presents the spectrum of findings at the prosthetic tip on TPBS in uncomplicated PCHA. Based on these findings the following recommendations are made: If (1) increased activity is present on flow or blood pool, (2) the MS increases in activity during 3–24 mos, (3) the MS has 3+ activity during 12–24 mos, or (4) the MS is > LS, then one should evaluate further for complications. Increasing activity in LS or LS activity of 3+ does not necessarily imply a complication.
Influence of fluid ingestion and carbohydrate supplementation on physical and mental performance during intermittent high-intensity exercise
Authors: P Watson, C A Davison, S Smithies, R J Maughan
Journal: British Journal of Sports Medicine (2010)

Carbohydrate (CHO) ingestion results in positive effects on exercise capacity, repeated sprint speed and sport-specific skill performance during intermittent exercise. This study evaluated the effects of lower concentrations of CHO on performance during intermittent exercise. Ten healthy males (mean±SD age 25±3 years; height 1.75±0.06 m; mass 75.9±6.4 kg; VO 2max 54.2±5.0 ml/kg/min) completed four 15-min periods of intermittent running, consisting of maximal sprinting interspersed with periods of running and walking (Loughborough Intermittent Shuttle Test). This was followed by the multistage shuttle-running fitness test (MSFT) to volitional exhaustion. Subjects consumed 3 ml/kg body mass of plain water, a 3% CHO solution or a 6% CHO solution before exercise and a further 1.5 ml/kg body mass of the appropriate drink after each 15-min block. A trial with no fluid ingestion was also completed. Sprint time, heart rate, core temperature, perceived exertion and thermal stress were recorded at regular intervals. Cognitive function was assessed using a computer-based test battery. Time to exhaustion in the MSFT was 9.9±2.0 min, 10.2±2.0 min, 10.9±1.9 min and 11.2±1.8 min in the no fluid, water, 3% and 6% CHO trials, respectively (p=0.004). Core temperature reached 38.9±0.4°C during the no fluid trial, 38.5±0.4°C in the water trial and 38.6±0.3°C at the end of the CHO trials (p=0.011). There was no change in response times to a visual search task in the no fluid and water trials, but CHO ingestion improved response times after exercise (3% CHO, p=0.036; 6% CHO, p=0.041). These data suggest that drinks containing lower CHO concentrations can produce improvements in exercise capacity and motor response times similar to those observed with the ingestion of the amounts of CHO found in many sports drinks. The study was carried out in relation to the product Powerade and was funded in part by The Coca-Cola Company.
Role of autologous lymphocyte cytotoxicity in colonic neoplasia.
Authors: P Gallagher, B M Vose, M Moore, P F Schofield
Journal: Gut (1982)

The T-lymphocyte mediated killing of autologous carcinoma colon cells was investigated. There was no change in the incidence of activity with advanced disease, age, or nutritional status of the patient and no difference could be demonstrated in lymphocytes extracted from blood, draining lymph nodes, or the tumour itself. Nevertheless. T-lymphocyte activity did appear to be specific for the patients9s own tumour, as it was rarely observed with allogeneic tumours. There was also no correlation with lymphocyte natural killer activity. The in vitro studies demonstrated patient specific T-lymphocyte activity in 23 of 47 patients with carcinoma of the colon, but the results do not correlate with clinical and pathological findings.
TCT-263 Coronary Evaginations Are Caused By Positive Vessel Remodeling And Are Nearly Absent Following Implantation Of Newer-Generation Drug-Eluting Stents: An Optical Coherence Tomography and Intravascular Ultrasound Study
Authors: Maria Radu, Lorenz Räber, Bindu Kalesan, Takashi Muramatsu, Henning Kelbaek, Jung Heo, Erik Jørgensen, Steffen Helqvist, Vasim Farooq, Salvatore Brugaletta, Hector M. Garcia-Garcia, Peter Juni, Kari Saunamäki, Stephan Windecker, Patrick Serruys
Journal: Journal of the American College of Cardiology (2012)
Why Do a Lung Scan?
Authors: Jon D. Shoop
Journal: JAMA (1974)

WHY do a lung scan—a question asked by physicians in many types of practices, and with good reason. If a lung scan is being considered to confirm or exclude the diagnosis of pulmonary embolism, the question can be answered with some certainty, but not unequivocally, because published studies of efficacy of lung scan are few. If the lung scan is being considered as an aid in diagnosis of a patient with pulmonary disease other than pulmonary embolism, the information being sought must be well defined, since such diseases produce generalized abnormalities of both perfusion and ventilation, and scanning studies do not result in specific diagnoses. Such disclaimers, however, do not negate the value of the technique of lung scanning; they merely advise circumspection in its use. <h3>Diagnosis and Prevention</h3> It is not the purpose of this article to discuss the therapy for thromboembolic disease, but the stage must be set
Abstract 3764: Loss of β2SP (ELF) enhances the stem-like traits and invasiveness of HCC cells.
Authors: Xiuling Zhi, Ling Lin, Narayan Shivapurkar, Wilma Jogunoori, Lopa Mishra, Aiwu R He
Journal: Cancer Research (2013)

Abstract β2SP(ELF) is one of adapter proteins for Smad3/Smad4 complex formation during TGF-β signal transduction. 40% of β2SP+/- mice spontaneously develop hepatocellular carcinoma (HCC) and most cases of human HCC, gastric cancer, and lung cancer demonstrate significant reductions in β2SP expression. In our study, we investigated the possible mechanism for loss of β2SP induced HCC tumorigenesis. Recent studies have highlighted the involvement of cancer stem cells during the formation and progression of various types of cancers, epithelial cells that have undergone EMT (epithelial mesenchymal transition) acquire stem-cell properties during cancer development. Giving the role of TGF-beta signaling in stem cell differentiation and EMT during embryonic development, we hypothesize loss of β2SP results in alteration of liver stem cell that may contribute to the development of HCC in β2SP+/− mice. It has been shown that EpCAM-positive adult liver cells has stem cell property and can differentiate into functional hepatocytes in xenograft model. We found that EpCAM-positive hepatocyte number doubled in β2SP+/− mouse compared to wild type by fluorescence-activated cell sorter (FACS). Furthermore EpCAM level in β2SP+/− mouse liver was three times higher than that in the liver of wild type mouse. To study the mechanism by which Epcam is regulated by β2SP, HCC cells were transfected by β2SP siRNA. Inhibition of β2SP increased the expression of Epcam, and EMT markers vimentin was increased and E-cadherin expression was decreased in PLC/PRF/5 and SNU449 cells, while TGF-β1 and Smad3 rescued the expression of Epcam and E-cadherin, but not vimentin. We also found that suppression of β2SP expression promotes adhesion, migration and cloning formation of PLC/PRF/5 and SNU449 cells. Our data suggests loss of β2SP enhances the stem-like traits and invasiveness of HCC cells. Citation Format: Xiuling Zhi, Ling Lin, Narayan Shivapurkar, Wilma Jogunoori, Lopa Mishra, Aiwu R He. Loss of β2SP (ELF) enhances the stem-like traits and invasiveness of HCC cells. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3764. doi:10.1158/1538-7445.AM2013-3764
Hypertensive Toxemias of Pregnancy
Authors: Frank A. Finnerty
Journal: New England Journal of Medicine (1952)

VERATRUM viride has been used for many years in the treatment of toxemia of pregnancy,1 and several recent reports have attested to its value.2 , 3 However, the effectiveness of the drug has been hampered by the use of crude extracts that were variable in composition and effect, making dosage adjustment difficult and toxic reactions frequent. Since purified extracts of Veratrum have been developed for the treatment of essential hypertension,4 , 5 it seemed pertinent to investigate the effects of such extracts in the toxemias of pregnancy. The availability of purified, well assayed extracts of uniform potency has permitted standard dosage and dosage schedules, . . .
Effect of Propranolol on Arrhythmias following Coronary Artery Occlusion in Dogs
Authors: R. G. Shanks, D. Dunlop
Journal: Cardiovascular Research (1967)

Electrocardiograms were obtained from conscious dogs before and on the four days after acute ligation of a branch of the left coronary artery. The intravenous injection of propranolol did not abolish the arrhythmias present 24 hr. after ligation, but reduced or abolished the exaggerated ectopic response to adrenaline on the second to fourth days after ligation. This effect resulted from blockade of adrenergic β-receptors in the myocardium.
Abstract 4608: Autophagy is required for prostate cancer progression.
Authors: Marco A. De Velasco, Yurie Kura, Naomi Ando, Emiko Fukushima, Yuji Hatanaka, Yutaka Yamamoto, Nobutaka Shimizu, Kazuhiro Yoshimura, Masahiro Nozawa, Kazuhiro Yoshikawa, Kazuto Nishio, Hirotsugu Uemura
Journal: Cancer Research (2013)

Abstract Autophagy (also referred to as macroautophagy) is a self-catabolic process that maintains intracellular homeostasis and prolongs cell survival by the autophagosomic-lysosomal degradation of cytoplasmic contents during metabolic stress or nutrient starvation. Inactivation of PTEN tumor suppressor function is a common characteristic of human prostate cancer that leads to the upregulation of the PI3K/Akt/mTOR signaling pathway, and has emerged as promising candidate for targeted therapies. mTOR is one of the upstream regulators of autophagy, therefore, inhibiting the PI3K/Akt/mTOR axis putatively stimulates autophagy. However, the role of autophagy in cancer is complex, acting both as a tumor suppressor and promoter, and its role in prostate tumorigenesis remains to be defined. Here we demonstrate that prostate cancer is dependent on autophagy for its growth and progression through the use genetically modified mouse models of prostate cancer. We had previously reported a conditional knockout mouse model in which homozygous deletion of PTEN lead to the stage-specific development of invasive adenocarcinoma. Characterization of tumors from the mice showed that although autophagy was suppressed early in tumor development, tumors eventually restored autophagic function despite increased PI3K/Akt/mTOR signaling. To determine the effect of defective autophagy on prostate cancer progression, we generated prostate-specific conditional double knockout mice harboring both inactivated PTEN and ATG7, a key regulator for the formation of autophagosomes. Prostate-specific inactivation of ATG7 function alone did not result in changes to the development or function of the prostate gland. Prostate-specific inactivation of both PTEN and ATG7 led to the early development of prostate adenocarcinoma similar to homozygous PTEN-mutant mice. However, prostate tumors failed to progress and showed regression. Our data suggests that impaired autophagy can be induced independent of mTOR and defective autophagy contributes to suppress tumor progression. Thus, our findings support the role of autophagy as a therapeutic target for advance prostate cancer. Citation Format: Marco A. De Velasco, Yurie Kura, Naomi Ando, Emiko Fukushima, Yuji Hatanaka, Yutaka Yamamoto, Nobutaka Shimizu, Kazuhiro Yoshimura, Masahiro Nozawa, Kazuhiro Yoshikawa, Kazuto Nishio, Hirotsugu Uemura. Autophagy is required for prostate cancer progression. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4608. doi:10.1158/1538-7445.AM2013-4608
Case 15-1977
Authors: Richard C. Cabot, Robert E. Scully, James J. Galdabini, Betty U. McNeely, Donald P. Goldstein, William R. Welch
Journal: New England Journal of Medicine (1977)

Presentation of CaseA 15-year-old boy was admitted to the hospital because of unresponsiveness and quadriparesis.He was in good health until seven weeks previously, when fever and a sore throat developed and persisted for two days. He soon began to complain of headaches, worse on arising and on bending forward. He became detached and uninterested in his usual activities. Four weeks before entry slurred speech was noted, and he was observed to trip easily and to spill food from his hands.Three and a half weeks before admission he entered another hospital, where neurologic examination revealed that he was . . .
Evidence of a reentry circuit in the common type of atrial flutter in man.
Authors: M Disertori, G Inama, G Vergara, M Guarnerio, A Del Favero, F Furlanello
Journal: Circulation (1983)

To investigate the mechanism of atrial flutter (AF) in humans, we studied 13 patients during episodes of spontaneous common AF, with simultaneous multiple atrial endocavitary recordings and atrial programmed stimulation. In all patients, low paraseptal atrial activation preceded high right atrial activation, and the latter preceded mid- or low lateral right atrial activation (recorded in five patients). Programmed atrial stimulation resulted in early reset of the AF cycle, with an unchanged poststimulation AF activation pattern. The poststimulation cycle recorded from an even potential to the site of stimulation was always shorter than the basic flutter cycle length. The poststimulation cycle recorded at the site of stimulation was always equal to or longer than the flutter cycle length. These results strongly favor the existence of a reentry circuit to which the extrastimulus has access.
Androgenic therapy for Waldenstrom's macroglobulinemia
Authors: Luis F. Porrata, Svetomir N. Markovic
Journal: American Journal of Hematology (2006)

To the Editor: Idiopathic thrombotic thrombocytopenic purpura (TTP) is a lifethreatening disease characterized by thrombocytopenia, microangiopathic hemolytic anemia, fever, neurologic changes, and renal dysfunction and is related to autoantibodies against von Willebrand factor cleaving metalloprotease [1].Clopidogrel is an antiplatelet drug used to prevent coronary stent thrombosis; however, TTP as its complication has been described [2].Clopidogrel-associated TTP (CA-TTP) presenting with coronary artery thrombosis is extremely rare.Here, a patient with CA-TTP presenting with coronary artery occlusion is described.A 66-year-old woman with diabetes mellitus, parathyroidectomy, hypertension, peptic ulcer, anxiety, and depression presented in June 2004 with a subendocardial myocardial infarction.She underwent a percutaneous transluminal coronary angioplasty (PTCA) and stent placement of the left anterior descending (LAD) artery.She was placed on 300 mg clopidogrel (loading dose) followed by 75 mg qd.She remained asymptomatic until August 2004 when she developed unstable angina and was transferred to our hospital for PTCA.Her medications were digoxin, metoprolol, venlafaxine, furosemide, simvastatin, insulin, clopidogrel, and aspirin.Complete blood count revealed WBC 8.6 Â 10 9 /L, hemoglobin 12.5 g/dL, platelet 72 Â 10 9 /L, with normal WBC differential counts.Coronary angiogram showed 90% occlusion of the LAD artery just proximal to the previously placed stent.She underwent PTCA and stent placement of the lesion and was placed on 12-h eptifibatide infusion.The next day, platelet count was 40 Â 10 9 /L.Hematology consultation was obtained.Her physical examination was unremarkable.Blood smear showed anisopoikilocytosis, polychromasia, and schistocytes 2/high-power-field.Other blood tests were as follows: hemoglobin 9.9 g/dL, serum haptoglobin 20 mg/dL (low), reticulocyte 2.7%, lactate dehydrogenase (LDH) 5504 U/L, unconjugated bilirubin 2.0 mg/dL, blood urea nitrogen 54 mg/dL, creatinine 2.9 mg/dL, and normal clotting profile.CA-TTP was diagnosed based on recent clopidogrel use, coronary artery thrombosis, microangiopathic hemolytic anemia, thrombocytopenia, and renal dysfunction.Clopidogrel was discontinued and she received fresh frozen plasma and daily plasmapheresis (PE).Within 96 h, her platelet count was 148 Â 10 9 /L
Nicotine Patch for Smoking Cessation-Reply
Authors: Richard D. Hurt, Kenneth P. Offord
Journal: JAMA (1994)

In Reply.  —Dr Lahad's letter discusses the possible role that univariate disparities in various baseline factors might have in explaining the difference in smoking cessation rates in our double-blind, placebo-controlled, randomized trial. Adjustment for such factors is more critical in epidemiologic retrospective, nonrandomized studies where various biases may distort the findings.  Two points are noteworthy. First, our results showing the efficacy of transdermal nicotine replacement therapy are consistent with other randomized trials where, in general, active treatment results in a doubling of the smoking cessation rate. 1-3 Second, using logistic regression, we reanalyzed the 8-week and 1-year cessation rates, adjusting for the six baseline variables mentioned by Dr Lahad (employed, depressed or down, previously treated for depression, pack-years of cigarette smoking, serum cotinine level, and baseline withdrawal symptom score). Assignment to active patch treatment was still a significant predictor of cessation adjustment for these after 8 weeks (two-tail P
Radionuclide Findings in Arteriovenous Fistula Between Left Pulmonary Artery and Vein
Authors: H M ABDEL-DAYEM, M M MOHAMMAD, N KHAN, G ZIDA, R BAHAR, I M HIGAZI
Journal: Clinical Nuclear Medicine (1986)

Right-to-left extra cardiac shunts are usually congenital and are rarely due to trauma or complicating thoracic or vascular surgery. A case of a right-to-left cardiac shunt due to an arteriovenous fistula between the left pulmonary artery and the left pulmonary vein is reported. This may be the first report of this abnormality. The etiology is not clear. The case was investigated only by radionuclide procedures because the general condition of the patient was so poor that invasive procedures could not be undertaken.
On the spread and control of MDR-TB epidemics: An examination of trends in anti-tuberculosis drug resistance surveillance data
Authors: Ted Cohen, Helen E. Jenkins, Chunling Lu, Megan McLaughlin, Katherine Floyd, Matteo Zignol
Journal: Drug Resistance Updates (2014)

Multidrug resistant tuberculosis (MDR-TB) poses serious challenges for tuberculosis control in many settings, but trends of MDR-TB have been difficult to measure.We analyzed surveillance and population-representative survey data collected worldwide by the World Health Organization between 1993 and 2012. We examined setting-specific patterns associated with linear trends in the estimated per capita rate of MDR-TB among new notified TB cases to generate hypotheses about factors associated with trends in the transmission of highly drug resistant tuberculosis.59 countries and 39 sub-national settings had at least three years of data, but less than 10% of the population in the WHO-designated 27-high MDR-TB burden settings were in areas with sufficient data to track trends. Among settings in which the majority of MDR-TB was autochthonous, we found 10 settings with statistically significant linear trends in per capita rates of MDR-TB among new notified TB cases. Five of these settings had declining trends (Estonia, Latvia, Macao, Hong Kong, and Portugal) ranging from decreases of 3% to 14% annually, while five had increasing trends (four individual oblasts of the Russian Federation and Botswana) ranging from 14% to 20% annually. In unadjusted analysis, better surveillance indicators and higher GDP per capita were associated with declining MDR-TB, while a higher existing absolute burden of MDR-TB was associated with an increasing trend.Only a small fraction of countries in which the burden of MDR-TB is concentrated currently have sufficient surveillance data to estimate trends in drug-resistant TB. Where trend analysis was possible, smaller absolute burdens of MDR-TB and more robust surveillance systems were associated with declining per capita rates of MDR-TB among new notified cases.
Effect of seat belts on injuries to front and rear seat passengers.
Authors: B R Wild, J Kenwright, S Rastogi
Journal: BMJ (1985)

Data on 2520 occupants of cars involved in accidents were analysed in relation to injury and the severity of the crash to investigate the effect of rear seat passengers on injury to restrained and unrestrained front seat occupants and vice versa. Unrestrained front seat occupants showed a higher incidence of serious injury when there were rear seat passengers. The presence of a rear seat passenger did not affect significantly the overall incidence of injury among restrained front seat occupants within the range of crash severity considered. Unrestrained rear seat passengers behind unrestrained front seat occupants showed a higher incidence of moderate injury and a lower incidence of no injury than those behind restrained front seat occupants. It is concluded that legislation on seat belts has not greatly increased the risk of person to person injury.
Robert Lisle Gadd
Authors: Iain Robertson
Journal: BMJ (2005)

​ConsultantConsultant in obstetrics and gynaecology St Mary's Hospital, Manchester, 1967-86 (b Sale, Manchester, 1921; q Manchester 1945; MD, FRCS Ed, FRCOG), died from prostate cancer on 28 March 2005.




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Lisle Gadd served in the Royal Army Medical Corps from 1946 to 1948 with the Cold-stream Guards in Italy, Palestine, and Greece, reaching the rank of major. After specialist training in Manchester and Liverpool, in 1959 he was appointed consultant obstetrician and gynaecologist for Ashton, Hyde, and Glossop, where he pioneered the clinical use of amniocentesis. In 1967 he left Ashton and was appointed consultant obstetrician and gynaecologist at St Mary's Hospital, Manchester, where he developed a first class pregnancy diabetic clinic. He leaves a wife, Veronica; three children; and three grandchildren.
Presence of the BCR-ABL mutation Glu255Lys prior to STI571 (imatinib) treatment in patients with Ph+ acute lymphoblastic leukemia
Authors: Wolf-Karsten Hofmann, Martina Komor, Barbara Wassmann, Letetia C. Jones, Harald Gschaidmeier, Dieter Hoelzer, H. Phillip Koeffler, Oliver G. Ottmann
Journal: Blood (2003)