tbuckley/cabot-search huggingface dataset:
Abstract 2217: Stress-induced NQO1 controls stability of C/EBPα against 20S proteasomal degradation to regulate p63 expression with implications in protection against chemical-induced skin cancer
Authors: Brad A. Patrick, Anil K. Jaiswal
Journal: Cancer Research (2012)

Abstract In previous studies we have illustrated a role of cytosolic NAD(P)H:quinone oxidoreductase 1 (NQO1) in stabilization of tumor suppressor transcription factor p63 against 20S proteasomal degradation, resulting in thinning of epithelium and chemical-induced skin cancer [Oncogene (2011) 30, 1098-1107]. Current studies demonstrate that an intermediate pathway involving NQO1 control of C/EBPα against 20S proteasomal degradation also contributes to the upregulation of p63 expression and protection. Western and immunohistochemistry analysis revealed that disruption of NQO1 gene in mice and mouse keratinocytes led to degradation of C/EBPα and profound decrease of p63 gene expression. p63 promoter mutagenesis, transfection and ChIP assays identified C/EBPα binding site between nucleotide position −185 to −174 that allows C/EBPα to enhance p63 gene expression. Coimmunoprecipitation and immunoblot analysis demonstrated that 20S proteasomes directly interacted and degraded C/EBPβ. NQO1 direct interaction with C/EBPα led to stabilization of C/EBPα against ubiquitin-independent 20S proteasomal degradation and NQO1 protection of C/EBPα required binding of cofactor NADH. Exposure of skin and keratinocytes to stress agents benzo(a)pyrene, UVB, antioxidant t-BHQ and ionizing radiation led to induction of NQO1 and stabilization of C/EBPα protein resulting in an increase in p63 RNA and protein in wild type but not in NQO1-null mice. Collectively, the current data combined with previous suggest that stress-mediated induction of NQO1 acts both through stabilization of p63-transactivating C/EBPα and through direct stabilization of p63 to control keratinocyte differentiation leading to normal skin development and possibly contribute to protection against chemical/radiation-induced skin carcinogenesis. The studies are significant in light of the knowledge that 2-4% human individuals are homozygous and 23% are heterozygous for NQO1P187S mutation and might be susceptible to stress-induced skin diseases. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2217. doi:1538-7445.AM2012-2217
The relationship between ovarian stimulation and ovarian tumours
Authors: B. Tarlatzis
Journal: Human Reproduction Update (1995)

Journal Article The relationship between ovarian stimulation and ovarian tumours Get access B.C. Tarlatzis, B.C. Tarlatzis IVF Center ‘Geniki Kliniki’ 2 Gravias Street, Thessaloniki 546 45, Greece Search for other works by this author on: Oxford Academic PubMed Google Scholar G. Grimbizis, G. Grimbizis IVF Center ‘Geniki Kliniki’ 2 Gravias Street, Thessaloniki 546 45, Greece Search for other works by this author on: Oxford Academic PubMed Google Scholar J. Bontis, J. Bontis IVF Center ‘Geniki Kliniki’ 2 Gravias Street, Thessaloniki 546 45, Greece Search for other works by this author on: Oxford Academic PubMed Google Scholar S. Mantalenakis S. Mantalenakis IVF Center ‘Geniki Kliniki’ 2 Gravias Street, Thessaloniki 546 45, Greece Search for other works by this author on: Oxford Academic PubMed Google Scholar Human Reproduction Update, Volume 1, Issue 4, 1995, Page 428, https://doi.org/10.1093/humupd/1.4.428 Published: 01 July 1995
Statistics on misuse of drugs have been misused
Authors: G. V Stimson, M. Hickman, P. J Turnbull
Journal: BMJ (1998)

EDITOR —The government's anti-drugs strategy places great emphasis on reducing drug related crime.1 Part of its concern is based on evidence of high drug use among offenders and the assumption that crime is driven by the need to finance drug use and may be prevented if problem drug users are diverted into treatment. The white paper reports that “latest indications from a random sample of suspected offenders arrested by the police suggest that over 60% of arrestees have traces of illegal drugs …
Treatment of ingrowing toenails with liquid nitrogen spray cryotherapy.
Authors: T S Sonnex, R P Dawber
Journal: BMJ (1985)

Ingrowing toenails are a common debilitating condition and often require surgical intervention. In 44 patients liquid nitrogen spray cryotherapy produced a rate of success comparable with that of other nail sparing techniques but had the advantage of being a quick, simple, and cheap outpatient procedure that could be carried out with limited facilities and without anaesthesia.
Coordinated neonatal screening programme for haemoglobin disorders is needed
Authors: A. Streetly, K. Maxwell, B. Campbell
Journal: BMJ (1998)

EDITOR—Modell et al's audit of prenatal diagnosis for haemoglobin disorders shows the lack of a public health approach to the issue in the United Kingdom.1

Firstly, numbers of affected births for sickle cell disease in the United Kingdom are not reported and, in fact, are not known. This reflects the lack of a coordinated neonatal screening programme (despite good evidence of the effectiveness of neonatal screening in reducing mortality) and of adequate data …
Abstract 3037: Cyr61/CCN1 regulates SHh through Notch signaling in pancreatic cancer cells
Authors: Inamul Haque, Monami Majumder, Sushanta K. Banerjee, Smita Mehta, Snigdha Banerjee
Journal: Cancer Research (2012)

Abstract Cyr61 (cysteine-rich 61)/CCN1, a member of the CCN family of growth factors that includes CTGF, NOV, WISP-1, WISP-2 and WISP-3, is associated with the development of various cancers. Our recent studies found Cyr61/CCN1 play a critical role in pancreatic carcinogenesis through the induction of EMT and stemness. Cyr61 mRNA and protein were detected in the early precursor lesions and their expression intensified with disease progression. However, the mode of action of CCN1 in the pancreatic carcinogenesis is unknown. In this study, we have shown that CCN1 regulates the expression of Sonic hedgehog (SHh), a lipid-modified secreted signaling protein, plays a critical role in pancreatic cancer development from Pan1N lesions to invasive growth of the disease. Moreover, we also found that SHh regulation by CCN1in pancreatic cancer cells is mediated through the regulation Notch1 signaling pathway. These extensive studies proposed that targeting Cyr61/CCN1 can provide a new treatment option for patients with pancreatic cancer as blocking CCN1 simultaneously two critical pathways (i.e., SHh and Notch1) associated with the development of the disease as well as drug resistence. (THIS WORK IS SUPPORTED BY VA MERIT GRANT TO SB). Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3037. doi:1538-7445.AM2012-3037
Treatment of Blepharospasm.
Authors: Peter A. Callan
Journal: JAMA (1891)

<h3>To the Editor:</h3> —In the last number ofThe Journal(December 27, 1890), under the heading of " Treatment of Blepharospasm," Giraud, (<i>Thése de Paris</i>) is quoted as treating this annoying and at times intractable affection by forcible dilatation, using a pair of retractors or a spring speculum—the separation of the lids being carried to a degree of exposing the conjunctival culde-sac—and keeping the eyelids in this position for three or four minutes. For several years I have been using a similar method in my clinic at the New York Eye and Ear Infirmary—with the difference that I do not forcibly put the orbicularis palpebrarum on the stretch. The good results, not from stretching, but from the exposure of the sensitive cornea to daylight—the natural stimulus of the eye. In all cases of conjunctival or corneal trouble this procedure cures the blepharospasm if it exists. The speculum is put between the
Subjective Bias of the Clinical Pharmacologist
Authors: Theodore Greiner
Journal: JAMA (1962)

SUBJECTIVE BIAS brings to mind the importance of the double-blind test, which is the only scientific device specifically developed for the clinical investigation of drugs. Its principle is a familiar one: During the research, neither the patient nor his physician knows whether the allegedlyactive drug, a placebo, or a known standard drug for comparison is being given. In that way, the physician's attitude can be isolated so it will neither influence his judgment, nor cause the patient's improvement to be ascribed to the drug when it is actually a nonpharmacological effect. By excluding subjective bias, the double-blind test has made therapeutic research scientific. Few drugs can be confirmed to be of value without its use. However, the double-blind test eliminates subjective bias only from the data of a single experiment. If we assume that all subjective bias is eliminated, we overlook the factor which makes clinical pharmacology such a confused
Persistent Organic Pollutants Modify Gut Microbiota–Host Metabolic Homeostasis in Mice Through Aryl Hydrocarbon Receptor Activation
Authors: Limin Zhang, Robert G. Nichols, Jared Correll, Iain A. Murray, Naoki Tanaka, Philip B. Smith, Troy D. Hubbard, Aswathy Sebastian, Istvan Albert, Emmanuel Hatzakis, Frank J. Gonzalez, Gary H. Perdew, Andrew D. Patterson
Journal: Environmental Health Perspectives (2015)

BackgroundAlteration of the gut microbiota through diet and environmental contaminants may disturb physiological homeostasis, leading to various diseases including obesity and type 2 diabetes. Because most exposure to environmentally persistent organic pollutants (POPs) occurs through the diet, the host gastrointestinal tract and commensal gut microbiota are likely to be exposed to POPs.ObjectivesWe examined the effect of 2,3,7,8-tetrachlorodibenzofuran (TCDF), a persistent environmental contaminant, on gut microbiota and host metabolism, and we examined correlations between gut microbiota composition and signaling pathways.MethodsSix-week-old male wild-type and Ahr–/– mice on the C57BL/6J background were treated with 24 μg/kg TCDF in the diet for 5 days. We used 16S rRNA gene sequencing, 1H nuclear magnetic resonance (NMR) metabolomics, targeted ultra-performance liquid chromatography coupled with triplequadrupole mass spectrometry, and biochemical assays to determine the microbiota compositions and the physiological and metabolic effects of TCDF.ResultsDietary TCDF altered the gut microbiota by shifting the ratio of Firmicutes to Bacteroidetes. TCDF-treated mouse cecal contents were enriched with Butyrivibrio spp. but depleted in Oscillobacter spp. compared with vehicle-treated mice. These changes in the gut microbiota were associated with altered bile acid metabolism. Further, dietary TCDF inhibited the farnesoid X receptor (FXR) signaling pathway, triggered significant inflammation and host metabolic disorders as a result of activation of bacterial fermentation, and altered hepatic lipogenesis, gluconeogenesis, and glycogenolysis in an AHR-dependent manner.ConclusionThese findings provide new insights into the biochemical consequences of TCDF exposure involving the alteration of the gut microbiota, modulation of nuclear receptor signaling, and disruption of host metabolism.CitationZhang L, Nichols RG, Correll J, Murray IA, Tanaka N, Smith PB, Hubbard TD, Sebastian A, Albert I, Hatzakis E, Gonzalez FJ, Perdew GH, Patterson AD. 2015. Persistent organic pollutants modify gut microbiota–host metabolic homeostasis in mice through aryl hydrocarbon receptor activation. Environ Health Perspect 123:679–688; http://dx.doi.org/10.1289/ehp.1409055
THE TREATMENT OF ALCOHOLIC INEBRIETY.
Authors: FREDERICK PETERSON
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Late season interim estimates of influenza vaccine effectiveness reliably predict end of season estimates in Victoria, Australia, 2007 to 2012
Authors: S G Sullivan, H Kelly
Journal: Eurosurveillance (2013)

Twice each year the World Health Organization makes a recommendation for the composition of the influenza vaccine, based on circulating strains of influenza A(H3N2), A(H1N1) and B. Strain selection has always been based on immunogenicity studies with limited human data. Immunogenicity can be considered as a proxy for vaccine effectiveness (VE). However, only interim VE estimates for the target hemisphere can be considered in time for the strain selection meeting. Using surveillance data from Victoria, Australia, we retrospectively estimated and compared interim and final VE estimates for 2007 to 2012. In general, interim estimates were within five percentage points of final estimates. However, estimates made too early or in years of low influenza activity may be unreliable.
Computers in the surgery. The patient's view.
Authors: M Pringle, S Robins, G Brown
Journal: BMJ (1984)

A postal survey sent to 350 patients from two rural practices confirmed that an appreciable minority of patients (17%) were opposed to doctors using computers. The questionnaire distributed had been carefully designed to identify their opposition more specifically. Most of the general concern was accounted for by the 91 patients (31%) who feared that confidentiality of information would be reduced. The sensitive nature of medical information alerts patients to the possibility of diminished security of records and obliges practices considering acquiring a computer to ensure that these fears are not realised. Smaller proportions of patients were found to oppose computers on other grounds--namely, impersonality, economy, and general anxiety.
Nuclear magnetic resonance spectroscopy in diagnostic and investigative medicine.
Authors: G I Shulman, J R Alger, J W Prichard, R G Shulman
Journal: Journal of Clinical Investigation (1984)

N u uclear magnetic resonance (NMR)' spectroscopy, which has been used by chemists and physicists for more than 30 years, is now becoming a powerful technique in the medical sciences because of its unique ability to monitor intracellular metabolites noninvasively.The fundamental principle under- lying NMR spectroscopy is that nuclei of certain atoms, such as hydrogen ('H), phosphorus (31p), carbon (13C), fluorine ('9F), and sodium (23Na), are magnetic dipoles.In the presence of a strong magnetic field, the nuclei of these atoms align with or against the field in much the same way that a bar magnet tends to align itself with the earth's magnetic field.A pulse of perturbing electromagnetic energy at the resonant frequency is then used to tip the nuclei away from their orientation along the magnetic field lines.When the perturbing radiofrequency pulse is stopped, the nuclei return to their original lower energy orientations; in the process, they emit energy which can be picked up by a radiofrequency receiver and transformed, with the aid of a computer, into a spectrum.The different nuclei resonate in the same magnetic field at very different frequencies.For example, at a field of 8.4 T, the 'H-resonance is at 360 MHz while '3C and 3'P are near 90.5 and 145.8 MHz, respectively.Members of the same nuclear species occupying different positions in a molecule resonate at slightly different frequencies.The individual peaks of the spectrum arise from differences in the chemical bondings of individual
Vision Loss Associated With Amantadine Hydrochloride Use
Authors: Arnold H. Kadish
Journal: JAMA (1977)

<h3>To the Editor.—</h3> Amantadine hydrochloride (Symmetrel) has two separate and apparently unrelated pharmacologic actions: It is most commonly used to control the tremor of Parkinson disease, and it has an antiviral action in the prevention of type A influenza. Blurring of vision has been reported as an infrequent complication of drug use. The mechanism causing this problem is unknown. <h3>Report of a Case.—</h3> A 67-year-old man was first seen in 1973 for a routine eye examination. Apart from a mild astigmatic refractive error and the normal presbyopia of his age, the findings were completely within normal limits. He was seen again in August 1975 for a superficial corneal abrasion of the right eye, which cleared spontaneously without sequelae. In September 1975, his vision was fully correctable to 20/20 in each eye, with no evidence of incipient cataracts, glaucoma, macular degeneration of the retina, or optic nerve disease. In November 1976,
Intracellular signaling in the regulation of renal Na-K-ATPase. II. Role of eicosanoids.
Authors: T Satoh, H T Cohen, A I Katz
Journal: Journal of Clinical Investigation (1993)

We recently reported a novel intracellular mechanism of renal Na-K-ATPase regulation by agents that increase cell cAMP, which involves protein kinase A-phospholipase A2 and is mediated by one or more arachidonic acid metabolites (Satoh, T., H. T. Cohen, and A. I. Katz. 1992. J. Clin. Invest. 89:1496). The present studies were, therefore, designed to assess the role of eicosanoids in the modulation of Na-K-ATPase activity in the rat cortical collecting duct. The effect of various cAMP agonists (dopamine, fenoldopam, vasopressin, forskolin, and dibutyryl cAMP), which inhibited the pump to a similar extent (approximately 50%), was independent of altered Na entry as it was elicited in the presence of amiloride or nystatin, or when NaCl was replaced with choline Cl. This effect was completely blocked by SKF 525A or ethoxyresorufin, two inhibitors of the cytochrome P450-dependent monooxygenase pathway, or by pretreating the animals with CoCl2, which depletes cytochrome P450. Equimolar concentrations (10(-7) M) of the cyclooxygenase inhibitors indomethacin or meclofenamate caused only a partial inhibition of the cAMP agonists' effect on the pump, whereas nordihydroguaiaretic acid or A 63162, two inhibitors of the lipoxygenase pathway, were without effect. Furthermore, two products of this pathway, leukotriene B4 and leukotriene D4, had no effect on Na-K-ATPase activity, and ICI 198615, a leukotriene receptor antagonist, did not alter pump inhibition by cAMP agonists. Several P450 monoxygenase arachidonic acid metabolites (5,6-epoxyeicosatrienoic acid; 11,12-epoxyeicosatrienoic acid; 11,12-dihydroxyeicosatrienoic acid; and 12(R)-hydroxyeicosatetraenoic acid) as well as PGE2 inhibited the Na:K pump in dose-dependent manner, but the effect of PGE2 was blocked when Na availability was altered, whereas that of 12(R)-HETE remained unchanged. We conclude that the cytochrome P450-monooxygenase pathway of the arachidonic acid cascade plays a major role in the modulation of Na:K pump activity by eicosanoids in the rat cortical collecting duct, and that products of the cyclooxygenase pathway may contribute to pump inhibition indirectly, by decreasing intracellular Na.
Plasma sRAGE Is Independently Associated With Urinary Albumin Excretion in Type 2 Diabetes
Authors: Per M. Humpert, Stefan Kopf, Zdenka Djuric, Thoralf Wendt, Michael Morcos, Peter P. Nawroth, Angelika Bierhaus
Journal: Diabetes Care (2006)

The receptor for advanced glycation end products (RAGE) has been shown to be involved in the pathogenesis of late diabetes complications (1–5; rev. in 6). However, little is known about the physiologic function of endogenous sRAGE, a splice variant of the full-length receptor found in plasma (7). It was recently reported that plasma sRAGE levels are diminished in type 1 and type 2 diabetes and correlate inversely with intima-media thickness (8,9), suggesting a protective role of high sRAGE levels in the development of late vascular complications. In view of these data, we aimed to decipher an association of plasma sRAGE with albuminuria as a marker of microvascular damage in 90 patients with type 2 diabetes and regular glomerular filtration rate (GFR).

Ninety type 2 diabetic patients were recruited from family practices, being referred to our diabetes outpatient clinic for specialist treatment after giving written consent. The study was approved by the local ethics committee. For eligibility, patients had to test positive for albuminuria in two separate urine samples (>20 mg/dl albumin). Detailed patient characteristics are given in Table 1. Twenty-four–hour urine samples were collected on 3 consecutive days, and the mean of albumin excretion was taken for statistical evaluation. All blood values as well as ambulatory 24-h blood pressure values (given as mean …
Loss of Sprouty1 Rescues Renal Agenesis Caused by Ret Mutation
Authors: Esteban J. Rozen, Hagen Schmidt, Xavier Dolcet, M. Albert Basson, Sanjay Jain, Mario Encinas
Journal: Journal of the American Society of Nephrology (2008)

Renal morphogenesis requires a balance between positive and negative signals, which are provided in part by the receptor tyrosine kinase Ret and the putative tumor suppressor Sprouty1, respectively. Tyrosine 1062 of Ret is a binding site for several adaptor and effector proteins, such as Grb2/Sos/Ras, which activate the ERK pathway. Mice lacking Ret tyrosine 1062 nearly mimic the phenotype of Ret-knockout mice, which includes renal agenesis. Sprouty1 regulates Ret activity by modulating the ERK pathway, but the mechanism by which this occurs is uncertain. Here, we show that loss of Sprouty1 rescues the renal agenesis and early postnatal lethality caused by lack of Ret tyrosine 1062. The kidneys and lower urinary tracts of double-mutant mice developed normally. This effect was specific to the urinary system, because loss of Sprouty1 did not rescue the defects in the enteric nervous system characteristic of animals lacking Ret tyrosine 1062. These results suggest that Sprouty1 can modulate ERK signaling downstream of Ret, independent of Grb2/Sos/Ras, during renal morphogenesis.
Duodenal Obstruction at the Ligament of Treitz
Authors: James W. Major, Edward J. Ottenheimer, William A. Whalen
Journal: New England Journal of Medicine (1960)

THE purpose of this paper is to present a case of duodenal obstruction at the ligament of Treitz treated successfully by a simple operative procedure, reported recently by Strong.1 A survey of the literature reveals little agreement on the management of this condition, and, indeed, there is considerable doubt whether it exists at all. Almost invariably, however, one finds it listed as one of the causes of duodenal stasis.It was described first by Rokitansky in 1861, and excellent reviews of the subject are given by Pool, Niles and Martin2 and Partpilio,3 who depict the waxing and waning of clinical . . .
Severe resistance to insulin and insulin-like growth factor-I in cells from a patient with leprechaunism as a result of two mutations in the tyrosine kinase domain of the insulin receptor
Authors: Christèle Desbois-Mouthon, Claude Danan, Serge Amselem, Marie-José Blivet-Van Eggelpoel, Caroline Sert-Langeron, Michel Goossens, Claude Besmond, Jacqueline Capeau, Martine Caron
Journal: Metabolism (1996)