Isoniazid and Ethambutol Absorption with Jejunoileal Bypass
Authors: RON E. POLK
Journal: Annals of Internal Medicine (1978)

Letters and Corrections1 September 1978Isoniazid and Ethambutol Absorption with Jejunoileal BypassRON E. POLK, PHARM. D., MARVIN TENENBAUM, M.D., BERRY KLINE, PH.D.RON E. POLK, PHARM. D.Search for more papers by this author, MARVIN TENENBAUM, M.D.Search for more papers by this author, BERRY KLINE, PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-89-3-430_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Bruce and Wise (1) have emphasized that serum levels of antituberculous agents should be measured in patients with jejunoileal bypass to assure adequate intestinal absorption. We report here our results in a similar patient.The patient was a 36-year-old woman who weighed 173 kg when she underwent a jejunoileal bypass (0.305m to 0.254m [12 in. to 10 in.]) at the Medical College of Virginia in 1974. She did well until April 1978, when she had the onset of fever, night sweats, and dull, nonradiating, anterior chest pain; at that time she was admitted to another hospital. Results...References1. BRUCEWISE RL: Tuberculosis after jejunoileal bypass for obesity. Ann Intern Med 87:574-576, 1976 LinkGoogle Scholar2. EIDUSHARNANANSINGH LA: A more sensitive spectrophotometric method for determination of isoniazid in serum or plasma. Clin Chem 17:492-494, 1971 CrossrefMedlineGoogle Scholar3. LEEBENET CL: Gas-liquid chromatographic determination of ethambutol in plasma and urine of man and monkey. J Chromatogr 128:188-192, 1976 CrossrefMedlineGoogle Scholar4. LEEGAMBERTOGLIOBRATERBENET CJDL: Kinetics of oral ethambutol in the normal subject. Clin Pharmacal Ther 22:615-621, 1977 CrossrefMedlineGoogle Scholar5. MELANDERDANIELSONHANSONJANSSONRERUPSCHERSTENTHULINWAHLIN AKALCBTE: Reduction of isoniazid bioavailability in normal men by concomitant intake of food. Acta Med Scand 200:93-97, 1976 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: School of Pharmacy and Division of Infectious Diseases Department of Medicine Medical College of Virginia Virginia Commonwealth University Richmond, VA 23298 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByPharmGKB summaryThe Influence of Bypass Procedures and Other Anatomical Changes in the Gastrointestinal Tract on the Oral Bioavailability of DrugsTrends in oral drug bioavailability following bariatric surgery: examining the variable extent of impact on exposure of different drug classesA systematic review of drug absorption following bariatric surgery and its theoretical implicationsBiowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Isoniazid**A project of the International Pharmaceutical Federation FIP, Groupe BCS, www.fip.org/bcs.Review: Medication Delivery in the Short-Bowel SyndromeAntituberculosis drug levels after jejunoileal bypass 1 September 1978Volume 89, Issue 3Page: 430-431KeywordsFeversIschemiaIsoniazidSweat Issue Published: 1 September 1978 PDF DownloadLoading ...