Intestinal Pseudo-Obstruction in a Diabetic Man: Role of the Mitochondrial A3243G Mutation
Authors: Yuji Aoki, Shigetoshi Hosaka, Kendo Kiyosawa
Journal: Annals of Internal Medicine (2002)

Letters15 October 2002Intestinal Pseudo-Obstruction in a Diabetic Man: Role of the Mitochondrial A3243G MutationYuji Aoki, MD, Shigetoshi Hosaka, MD, PhD, and Kendo Kiyosawa, MD, PhDYuji Aoki, MDShinshu University School of Medicine; Matsumoto 390-8621, JapanSearch for more papers by this author, Shigetoshi Hosaka, MD, PhDShinshu University School of Medicine; Matsumoto 390-8621, JapanSearch for more papers by this author, and Kendo Kiyosawa, MD, PhDShinshu University School of Medicine; Matsumoto 390-8621, JapanSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-137-8-200210150-00031 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:A 33-year-old Japanese man was referred to our hospital in October 2000 for evaluation of a 4-month history of unexplained abdominal pain and diarrhea, which had already prompted two hospitalizations for intestinal pseudo-obstruction. He had developed diabetes mellitus at 20 years of age and hearing loss at 27 years of age but had no history of seizures or stroke-like episodes. His mother and her brother also had diabetes mellitus. The patient was short in stature (159 cm) and weighed 41 kg.Physical examination by a neurologist revealed no signs of neuromuscular disease, including diabetic neuropathy, but bilateral ...References1. Maassen JA, Kadowaki T. Maternally inherited diabetes and deafness: a new diabetes subtype. Diabetologia. 1996;39:375-82. [PMID: 8777986] CrossrefMedlineGoogle Scholar2. Wallace DC. Mitochondrial DNA sequence variation in human evolution and disease. Proc Natl Acad Sci U S A. 1994;91:8739-46. [PMID: 8090716] CrossrefMedlineGoogle Scholar3. Kuroiwa T, Kuwata T, Nakayama T, Takemura T, Sakuta M, Ichinose S, et al . Mitochondrial encephalomyopathy showing prominent microvacuolation and necrosis of intestinal smooth muscle cells: a case diagnosed by rectal biopsy. Acta Neuropathol Berl. 1998;96:86-90. [PMID: 9678517] CrossrefMedlineGoogle Scholar4. Di Lorenzo C. Pseudo-obstruction: current approaches. Gastroenterology. 1999;116:980-7. [PMID: 10092321] CrossrefMedlineGoogle Scholar5. Chinnery PF, Jones S, Sviland L, Andrews RM, Parsons TJ, Turnbull DM, et al . Mitochondrial enteropathy: the primary pathology may not be within the gastrointestinal tract. Gut. 2001;48:121-4. [PMID: 11115833] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Shinshu University School of Medicine; Matsumoto 390-8621, Japan PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPaediatric Intestinal Pseudo-obstruction: Evidence and Consensus-based Recommendations From an ESPGHAN-Led Expert GroupPediatric Chronic Intestinal Pseudo-obstructionChronic Intestinal Pseudo-Obstruction in ChildhoodMitochondrial DNA A3243G mutation involved in familial diabetes, chronic intestinal pseudo-obstruction and recurrent pancreatitisUnusual occurrence of intestinal pseudo obstruction in a patient with maternally inherited diabetes and deafness (MIDD) and favorable outcome with coenzyme Q10Clinical features, diagnosis and management of maternally inherited diabetes and deafness (MIDD) associated with the 3243A>G mitochondrial point mutationGenetic, pathogenetic, and phenotypic implications of the mitochondrial A3243G tRNALeu(UUR) mutationDiabète et cytopathies mitochondriales : données anatomo-pathologiquesMitochondrial DNA Mutation and Functional DyspepsiaGastric Dysmotility Associated with Accumulation of Mitochondrial A3243G Mutation in the StomachGastrointestinal manifestations of mitochondrial disease 15 October 2002Volume 137, Issue 8Page: 703-704KeywordsCellsDiabetes mellitusEpithelial cellsHearingMitochondriaMitochondrial DNAMucous membranesRectumStomachXylose ePublished: 15 October 2002 Issue Published: 15 October 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...