tbuckley/cabot-search huggingface dataset:
Hepatitis Antigen in Pleural Effusion
Authors: WAYMAN D. MERRILL
Journal: Annals of Internal Medicine (1977)

Letters and Corrections1 July 1977Hepatitis Antigen in Pleural EffusionWAYMAN D. MERRILL, M.D., J. RANDOLPH FARRIS, M.D., OTIS ROUNDS, M.D.WAYMAN D. MERRILL, M.D.Search for more papers by this author, J. RANDOLPH FARRIS, M.D.Search for more papers by this author, OTIS ROUNDS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-87-1-120_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We wish to report isolation of hepatitis antigen from a pleural effusion complicating a case of hepatitis. Pleural effusion, as a complication of hepatitis, was first reported in 1971 (1). Later, a series of reported cases of hepatitis showed again that hepatitis may rarely be complicated and even preceded by a pleural effusion (2). Hepatitis antigen has been reported in urine, saliva, bile, feces, semen, breast milk, tears, vaginal secretions, and sneeze droplets, but never before in pleural fluid (3).A 40-year-old Latin American man presented with a complaint of anorexia and symptoms of weakness, nausea, and...References1. GROSSGERDING PD: Pleural effusion associated with viral hepatitis. Gastroenterology 60:898-902, 1971 CrossrefMedlineGoogle Scholar2. KATSILABROSTRIANDAFILLOUKONTOYIANNIS LGP: Pleural effusion and hepatitis. Gastroenterology 63:718, 1972 CrossrefMedlineGoogle Scholar3. GITNICKGOLDBERGKORETZ GLR: The liver and the antigens of hepatitis B. Ann Intern Med 85:488-496, 1976 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Internal Medicine Martin Luther King, Jr., General Hospital Los Angeles, CA 90059 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByPLEURAL EFFUSION ASSOCIATED WITH ACUTE HEPATITIS A INFECTIONPleural effusion coinciding with acute exacerbations in a patient with chronic hepatitis BDerrame pleural como única manifestación de hepatitis B 1 July 1977Volume 87, Issue 1Page: 120-120KeywordsAntigensBreast milkHepatitisHepatitis ANauseaPleural effusionSalivaSemenSneezingUrine Issue Published: 1 July 1977 PDF DownloadLoading ...
Reviews and Notes: Geriatrics: Medical Direction in Long-term Care: A Guidebook for the Future
Authors: Donald C. Kern
Journal: Annals of Internal Medicine (1994)

Literature of Medicine1 July 1994Reviews and Notes: Geriatrics: Medical Direction in Long-term Care: A Guidebook for the FutureDonald C. KernDonald C. KernVeterans Affairs Medical Center, Bedford, MA 01730.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-121-1-199407010-00039 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Medical Direction in Long-Term Care: A Guidebook for the FutureSecond edition. Steven A. Levenson; ed. 694 pages. Durham, North Carolina: Carolina Academic Press; 1993. $65.00.American physicians are faced with a rapidly increasing number of elderly patients. Although most elders live in their communities, demands for long-term care continue to spiral. Although the title of “nursing home” implies little need for physician input (and traditionally little has been given), the growing multiplicity and chronicity of disease and the advances in therapeutic sophistication have increased the demand for physician direction in long-term care. Most clinical training programs, including geriatric fellowships, ... Author, Article, and Disclosure InformationAffiliations: Veterans Affairs Medical Center, Bedford, MA 01730. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1994Volume 121, Issue 1Page: 79-80KeywordsDecision makingElderlyFellowshipsForecastingGeriatricsHealth care facilitiesHealth care quality assessmentLong-term careNursing homesPrevention, policy, and public health ePublished: 15 August 2000 Issue Published: 1 July 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Modem Trends in Orthopaedics—6
Authors: A. H. Woodward
Journal: JAMA (1972)

According to Apley, a   is an advance which may be safely copied. Certainly, most of these nine articles discuss subjects which have recently aroused much interest among orthopedists and, indeed, their patients. Inevitably, total joint replacement claims most attention. Total hip arthroplasty has completely changed the practice of many orthopedic surgeons. Spectacularly successful, it is at present the most satisfying reconstructive procedure an orthopedist can perform. However, as Parsons points out, it is still a time for caution: no one knows how the human body will react to the prolonged presence of polymethylmethacrylate or of small particles of metal or polyethylene. Complications of pulmonary embolus, dislocation, ectopic calcification, infection, loss of fixation, and sudden operative death are rightly emphasized.  The history of knee replacement includes some reasonable results with the use of a hinged prosthesis, but the modern trend is for knee joint prostheses without mechanical linkage. Since
The occlusal plane in the facial context: inter-operator repeatability of a new three-dimensional method
Authors: Riccardo Rosati, Alberto Rossetti, Marcio De Menezes, Virgilio F Ferrario, Chiarella Sforza
Journal: International Journal of Oral Science (2012)

The repeatability of a non-invasive digital protocol proposed to evaluate the three-dimensional (3D) position of the occlusal plane in the face is assessed. Dental virtual models and soft tissue facial morphology of 20 adult subjects were digitally integrated using a 3D stereophotogrammetric imaging system. The digital 3D coordinates of facial and dental landmarks were obtained by two different operators. Camper's (facial) and occlusal (dental) planes were individuated, and their 3D relationships were measured. The repeatability of the protocol was investigated and showed no significant differences in repeated digitizations. The angle between occlusal and Camper's planes was smaller than 2° in the frontal and horizontal projections. In the sagittal projection, the angle was observed to be, on average, 4.9°. The determined occlusal plane pitch, roll and yaw values show good agreement with previously published data obtained by different protocols. The current non-invasive method was repeatable, without inter-operator differences and can facilitate assessment of healthy subjects. A method for imaging facial structures in 3D, without harmful X-rays, has been successfully demonstrated by researchers in Italy. By merging data from stereophotographic images of individual faces with laser scanning information from dental casts, Chiarella Sforza and colleagues at the Universita` degli Studi di Milano accurately determined the orientation of the occlusal plane—where the upper and lower teeth make contact. Two different operators repeated the process in 20 adult volunteers with errors generally less than 1 millimeter. This non-invasive type of imaging, although still technical and expensive, avoids the potential dangers of radiographic techniques such as X-rays and CT scanning. The technique could eventually prove useful for basic dental diagnoses and treatments, monitoring growth in children or even researching healthy volunteers to assess biological variability among populations.
Cardiac predictors of death after non-cardiac surgery evaluated by intention to treat.
Authors: A. Dirksen, E. Kjoller
Journal: BMJ (1988)

Cardiac risk factors were studied among patients who were admitted to hospital with appendicitis or a fracture of the proximal femur less than one year after being admitted with myocardial infarction. Of 99 patients with myocardial infarction and appendicitis, 87 underwent appendicectomy; and of 221 with myocardial infarction and hip fracture, 179 were operated on. The patients were studied on an intention to treat basis. The mortality within one month was 9% and 16% respectively. A history of congestive heart failure was the dominating risk factor, while ischaemic heart disease (recent myocardial infarction or angina pectoris) had no independent association with mortality. If the ventricular function is known additional preoperative information about the heart is of negligible value when estimating the mortality of non-cardiac surgery.
Chemical-Biological Warfare in Asia
Authors: Richard C. Harruff
Journal: JAMA (1983)

DURING the first six months of 1980, I was involved in the Indo-Chinese refugee relief effort in Thailand as a volunteer physician at Ban Vinai camp. This camp is the principal refuge of the Laotian Hmong population, who are enemies of the Communist Pathet Lao and Vietnamese governments because of the Hmong's collaboration with the United States in the war with North Vietnam. After the war, the Hmong maintained a strong resistance to Vietnam's troops until 1979, when they were defeated at Phu Bia, Laos. Now most of the Hmong are either refugees or under control of the Vietnamese occupying force, although the resistance continues on a much reduced level. Since 1976, there have been accounts by the Hmong of chemical-biological warfare activity against their fighters and their villages and in experimentation programs. Although this was not an issue at the time I was in Ban Vinai, I had evaluated
Intravenous immunoglobulin-mediated expansion of regulatory T cells in autoimmune patients is associated with increased prostaglandin E2 levels in the circulation
Authors: Mohan S Maddur, Jamma Trinath, Magalie Rabin, Francis Bolgert, Moneger Guy, Jean-Michel Vallat, Laurent Magy, Kithiganahalli N Balaji, Srini V Kaveri, Jagadeesh Bayry
Journal: Cellular and Molecular Immunology (2014)
Sex difference in infant mortality in India is reflected in England and Wales
Authors: I. Dawson
Journal: BMJ (2003)

<h3>Objective</h3> Index-to-ring finger ratio (IRFR) has been reported to be associated with joint osteoarthritis (OA). We aimed to evaluate the association between IRFR and trapeziometacarpal joint (TMCJ) OA in an elderly Korean population. <h3>Methods</h3> A population-based sample included 604 participants with mean age of 74.8 years. IRFR was radiographically measured by the ratio of length of the right second to fourth phalangeal bones ("phalangeal IRFR") and metacarpal bones ("metacarpal IRFR"), and was visually classified as either type 1 (index finger longer than or equal to ring finger) or type 2 (index finger shorter than ring finger). Odds ratios (ORs) for the presence of OA (Kellgren-Lawrence (KL) grade &gt; 1) and for severe OA (KL grade &gt; 2) were analyzed using logistic regressions. <h3>Results</h3> The phalangeal IRFR averaged 91.3%, the metacarpal IRFR 116.7%, and 304 out of 604 participants (50.3%) had type 2 IRFR. We found TMCJ OA in 112 participants (18.5%), and severe TMCJ OA in 37 participants (5.5%). Presence of TMCJ OA was significantly associated with age (OR 1.036; 95% CI 1.011-1.061) and metacarpal IRFR (OR 0.936; 95% CI 0.884-0.992), and severe TMCJ OA with age (OR 1.075; 95% CI 1.032-1.121) and type 2 IRFR (OR 3.057; 95% CI 1.128-8.288). <h3>Conclusion</h3> Radiographic, specifically metacarpal IRFR, was associated with the presence of TMCJ OA, and visual IRFR with severe TMCJ OA in both elderly Korean men and women. This study suggests that IRFR might serve as an easily measurable biomarker to identify patients vulnerable to TMCJ OA.
DIAGNOSTIC ACCURACY OF MYOCARDIAL T1 MAPPING IN CARDIAC AMYLOIDOSIS
Authors: Jose Maria Castellano, Eduardo Pozo, Anubhav Kanwar, Sarayu Ramachandran, Rajiv Deochand, Pablo Pazos, Ines Garcia-Lunar, Matthew Cham, Valentin Fuster, Javier Sanz
Journal: Journal of the American College of Cardiology (2013)
Multifocal lymphadenopathy associated with severe Kawasaki disease: a difficult diagnosis
Authors: F Falcini
Journal: Annals of the Rheumatic Diseases (2003)

A previously healthy 3½12 month old infant was admitted to the hospital with dyspnoea, malaise, and irritability in August 2001. One week before he had had an upper respiratory infection treated with amoxycillin and inhaled steroids; the day before admission he presented high grade (up to 40°C) temperature.

On admission he was febrile (39°C), pale, restless; his respiratory rate was 50/min and pulse 120 beats/min. Clinical evaluation showed oral cyanosis, redness of the pharynx, and bilateral suppurative conjunctivitis. A chest radiograph showed pulmonary infiltrates in the right lung.

Electrocardiography (ECG) and echo colour Doppler excluded cardiac abnormalities. An electroencephalogram showed diffuse slow waves. A lumbar puncture was performed to exclude a meningeal infection; the cerebrospinal fluid was clear with normal glucose and protein levels and a mild increase in mononuclear cells.

Blood tests showed: erythrocyte sedimentation rate (ESR) (Westergren) 120 mm/1st h, C reactive protein (CRP) 221 mg/l, white blood cells 16.8×109/l (neutrophils 75.2%), haemoglobin 94 g/l, and platelet count 504×10 …
Paradoxical effects of ?-estradiol on epidermal permeability barrier homeostasis
Authors: M. Tsutsumi, M. Denda
Journal: British Journal of Dermatology (2007)

Previous studies have demonstrated that sex hormones modulate epidermal permeability barrier homeostasis, and when the balance of these hormones is altered at menopause or during the menstrual cycle, skin sensitivity or barrier function is changed.To observe the direct effects of sex hormones on epidermal homeostasis.We examined the effects of topical application of sex hormones on permeability barrier recovery after tape stripping in the hairless mouse. To avoid the influence of systemic hormonal alteration, we employed male animals.Application of androgen (testosterone or androsterone) delayed the barrier recovery, and the delay was overcome by co-application of beta-estradiol. Progesterone also delayed the barrier recovery, but in this case the delay was enhanced by beta-estradiol.These results suggest that changes in sex hormone balance might be associated with the skin dysfunction that often occurs during menopause, and at certain points during the menstrual cycle.
Quantification of regional myocardial perfusion with generator-produced 62Cu-PTSM and positron emission tomography.
Authors: P Herrero, J Markham, C J Weinheimer, C J Anderson, M J Welch, M A Green, S R Bergmann
Journal: Circulation (1993)

BACKGROUND Noninvasive assessment of regional myocardial perfusion at rest and after stress is important for the objective evaluation of the effects of coronary artery disease and its response to therapy. Centers that do not have cyclotrons rely on generator-produced radioisotopes for assessment of regional myocardial perfusion with positron emission tomography (PET). The aim of the present study was to develop and implement an approach to quantify regional myocardial perfusion using copper(II) pyruvaldehyde bis-(N4-thiosemicarbazone) (PTSM) labeled with the generator-produced, positron-emitting radionuclide 62Cu (t1/2 = 9.7 minutes). METHODS AND RESULTS Regional perfusion was estimated from dynamic PET scans after intravenous administration of 62Cu-PTSM in 21 studies in 13 intact dogs evaluated over a wide range of myocardial flow values. In 15 interventions in nine dogs, regional perfusion was also estimated with H2(15)O. Regional perfusion with 62Cu-PTSM was estimated from dynamic blood and tissue time-activity curves, along with the model parameter k1 (forward rate of transport) and the PET parameter FBM (fraction of blood pool activity observed in tissue), using a two-compartment kinetic model. Arterial blood activity was corrected for red blood cell-associated 62Cu. In 44 comparisons, estimates of regional perfusion with 62Cu-PTSM correlated well with estimates obtained with concomitantly administered radiolabeled microspheres (y = 0.90x +/- 0.15, r = 0.95, p &lt; 0.05) over a flow range from 0.23 to 6.14 ml/g per minute. In five healthy human volunteers evaluated at rest with H2(15)O and 62Cu-PTSM, regional perfusion estimated with 62Cu-PTSM was not significantly different from that obtained with H2(15)O (1.05 +/- 0.36 versus 0.96 +/- 0.28 ml/g per minute). 62Cu-PTSM provided high-quality images of the heart. CONCLUSIONS The results of this study demonstrate that quantification of regional myocardial perfusion is feasible using generator-produced 62Cu-PTSM. Since 62Cu-PTSM can be used to estimate perfusion in the brain, kidney, and tumors as well as in the heart, it is an attractive tracer for centers that rely on generator-produced tracers for the evaluation of perfusion with PET.
Extended Use of Disposable Pressure Transducers
Authors: Roberta L. Luskin, Robert A. Weinstein, Catherine Nathan, William H. Chamberlin, Sherwin A. Kabins
Journal: JAMA (1986)

In a prospective randomized study, contamination rates of disposable pressure transducers changed every two days (n = 81) were compared with those changed at four (n = 26) or eight days (n = 50); the mean daily incidence of contamination was 3% for each group. After four days of use, the cumulative prevalences of contamination were similar. However, after eight days, the cumulative prevalence was significantly higher in transducers used without change (6.9%) than in those changed every two days (2.9%). Gram-negative bacilli were present in 63% of contaminated transducers; over half were from the patients' own flora. The only definite transducer-related bacteremia occurred on a day of initial contamination and should have been unaffected by the interval of change. Routine use of disposable transducers can be safely extended to four days, even in a busy intensive care unit.
Pemphigus controlled by dapsone
Authors: THADA PIAMPHONGSANT
Journal: British Journal of Dermatology (1976)

Three uncomplicated cases of pemphigus were clinically controlled by dapsone. Improvement was associated with decreasing titres of circulating intercellular antibodies. Interestingly, the sera from one case of pemphigus foliaceus contained intercellular antibodies found in the Malpighian and basal cell layers using the fluorescent technique and in the granular layer using the peroxidase technique. These findings suggest that the intercellular antibodies in pemphigus vulgaris and pemphigus foliaceus are similar but bind at different anatomical site
The Health of India
Authors: J. Megaw
Journal: BMJ (1946)

Service, a Service which has done so much for public health in India. Our lecturer, Sir John Megaw, was a very well known member of that Service. Although Sir John really needs no introduction to most of you, perhaps I may be permitted to remind you that he was for several years the Director, I believe the first Director, of the Tropical School of Medicine in Calcutta and that the success of that Institution and it has been
Immunological and Antiviral Responses After Therapeutic DNA Immunization in Chronic Hepatitis B Patients Efficiently Treated by Analogues
Authors: O Godon, H Fontaine, S Kahi, JF Meritet, D Scott-Algara, S Pol, ML Michel, M Bourgine
Journal: Molecular Therapy (2013)

A substudy of a phase I/II, prospective, multicenter clinical trial was carried out to investigate the potential benefit of therapeutic vaccination on hepatitis B e antigen-negative patients with chronic hepatitis B (CHB), treated efficiently with analogues. Patients were randomized in 2 arms, one receiving a hepatitis B virus (HBV) envelope DNA vaccine, and one without vaccination. At baseline, HBV-specific interferon (IFN)-γ–producing T cells were detected in both groups after in vitro expansion of peripheral blood mononuclear cells. Vaccine-specific responses remained stable in the vaccine group, whereas in the control group the percentage of patients with HBV-specific IFN-γ–producing T cells decreased over time. The vaccine-specific cytokine-producing T cells were mostly polyfunctional CD4+ T cells, and the proportion of triple cytokine-producer T cells was boosted after DNA injections. However, these T-cell responses did not impact on HBV reactivation after stopping analogue treatment. Importantly, before cessation of treatment serum hepatitis B surface antigen (HBsAg) titers were significantly associated with DNA or HBsAg clearance. Therapeutic vaccination in CHB patients with persistent suppression of HBV replication led to the persistence of T-cell responses, but further improvements should be searched for to control infection after treatment discontinuation. A substudy of a phase I/II, prospective, multicenter clinical trial was carried out to investigate the potential benefit of therapeutic vaccination on hepatitis B e antigen-negative patients with chronic hepatitis B (CHB), treated efficiently with analogues. Patients were randomized in 2 arms, one receiving a hepatitis B virus (HBV) envelope DNA vaccine, and one without vaccination. At baseline, HBV-specific interferon (IFN)-γ–producing T cells were detected in both groups after in vitro expansion of peripheral blood mononuclear cells. Vaccine-specific responses remained stable in the vaccine group, whereas in the control group the percentage of patients with HBV-specific IFN-γ–producing T cells decreased over time. The vaccine-specific cytokine-producing T cells were mostly polyfunctional CD4+ T cells, and the proportion of triple cytokine-producer T cells was boosted after DNA injections. However, these T-cell responses did not impact on HBV reactivation after stopping analogue treatment. Importantly, before cessation of treatment serum hepatitis B surface antigen (HBsAg) titers were significantly associated with DNA or HBsAg clearance. Therapeutic vaccination in CHB patients with persistent suppression of HBV replication led to the persistence of T-cell responses, but further improvements should be searched for to control infection after treatment discontinuation.
Ectopic Acromegaly: Localization of the Pituitary Growth Hormone-Releasing Hormone Producing Tumor by In-111 Pentetreotide Scintigraphy and Report of Two Cases
Authors: Olivier Morel, Philippe Giraud, Marie-Odile Bernier, Jean-Jacques Le Jeune, Vincent Rohmer, Pierre Jallet
Journal: Clinical Nuclear Medicine (2004)

Acromegaly is habitually caused by a pituitary growth hormone (GH)-secreting adenoma, resulting in elevated circulating levels of GH and insulinlike growth factor-1 (IGF-1). Ectopic acromegaly is of very rare occurrence, accounting for less than 1% of clinical acromegaly. This entity is more often than not related to a pancreatic or bronchial GH-releasing hormone (GH-RH) producing neuroendocrine tumor, which is responsible for a nonadenomatous hyperplasia of the pituitary somatotrophic cells. The authors report 2 cases of successful detection of a GH-RH-secreting tumor by In-111 pentetreotide scintigraphy, one in a lung and the other in the pancreas.
Medieval Medical Miniatures
Authors: Madeleine Pelner Cosman
Journal: JAMA (1987)

<i>Miniature</i>technically has nothing to do with size but rather metallic medium. A<i>miniature</i>is a lead-painted picture: red lead (in Latin,<i>minium</i>) was a major paint component for the splendid illustrations and illuminations of the handwritten books, the manuscripts, before printing's invention in the 15th century. <i>Miniature</i>in common parlance, however, meaning reduced scale and diminished size, fairly describes this petite 7×10-in shiny-papered text with 11 color and 60 black-and-white illustrations derived from manuscripts in two of the best English collections. The 5000 incredible manuscripts of Sir Hans Sloan (17th century) became the core of the British Museum collection, where Peter Murray Jones is senior research assistant in the Manuscript Department, British Library; the passion of Sir Henry Wellcome (19th century) for manuscripts ultimately stocked the Wellcome Institute for the History of Medicine in London. An itinerary through these treasuries requires of the guide either a lighthearted learning with