tbuckley/cabot-search huggingface dataset:
Modified Dialysis for Metabolic Alkalosis
Authors: RICHARD D. SWARTZ
Journal: Annals of Internal Medicine (1978)

Letters and Corrections1 March 1978Modified Dialysis for Metabolic AlkalosisRICHARD D. SWARTZ, M.D., JOHN F. JACOBS JR.RICHARD D. SWARTZ, M.D.Search for more papers by this author, JOHN F. JACOBS JR.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-88-3-432_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In an earlier issue, one of our group reported previous experience in treating severe metabolic alkalosis that complicates oliguric renal failure by use of hemodialysis with a specially prepared, high-chloride, low-acetate dialysis solution (1). This method corrected the metabolic abnormality and reversed its clinical sequelae, but the procedure was cumbersome, requiring large batches of dialysate and careful measurement of dialysate constituents. Further, the method was not adaptable for use with the "central delivery" or "proportioning" dialysate systems used in many hemodialysis units.The following case demonstrates the efficacy of a modification of this treatment using the REDY®...References1. SWARTZ R, RUBIN J, BROWN R, YAGER H, STEINMAN T, and FRAZIER H: Correction of postoperative metabolic alkalosis and renal failure with hemodialysis. Ann Intern Med 86:52-55, 1977 LinkGoogle Scholar2. ROBERTS M and PECKER E: Acid-base balance and the REDY® system. Monograph LSP#129, CCI Life Systems, Inc., Van Nuys, California, April 1976 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: RICHARD D. SWARTZ, M.D.; JOHN F. JACOBSJR.Affiliations: University of Michigan Medical School Ann Arbor, MI 48109 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAcute Complications Associated with HemodialysisCorrection of acid-base derangementsAcid-base disorders in medicineAcid dialysate correction of metabolic alkalosis in renal failureAcid-Base Disorders in End-Stage Renal Disease: Part IIHYPOCHLORAEMIC ALKALOSIS AFTER HIGH-FLUX CONTINUOUS HAEMOFILTRATION AND CONTINUOUS ARTERIOVENOUS HAEMOFILTRATION WITH DIALYSISTreatment of Metabolic Alkalosis in Renal FailureMetabolic Alkalosis 1 March 1978Volume 88, Issue 3 Page: 432-433 Keywords Medical dialysis Renal failure ePublished: 1 December 2008 Issue Published: 1 March 1978 PDF downloadLoading ...
Differential accumulation of diacyl and plasmalogenic diglycerides during myocardial ischemia.
Authors: D A Ford, R W Gross
Journal: Circulation Research (1989)

The recent discovery of neutral active choline and ethanolamine glycerophospholipid specific phospholipase C in myocardium (Wolf RA, Gross RW. J Biol Chem 1985;260:7295) has demonstrated a novel catabolic pathway that potentially contributes to the accumulation of amphiphilic metabolites during myocardial ischemia. To assess the potential importance of this pathway, we quantified the temporal course of alterations in myocardial 1-0-alk-1'-enyl-2-acyl-sn-glycerol (AAG) and 1,2-diacyl-sn-glycerol (DAG) content during control and ischemic intervals in an isolated perfused Langendorf model. AAG accumulated over fivefold to 8.70 and 18.27 nmol/g dry in 20- and 60-minute ischemic rabbit hearts, respectively (p less than 0.02). The only AAG molecular species that was detected in substantial amounts in control or ischemic rabbit hearts was 1-0-hexadec-1'-enyl-2-acyl-sn-glycerol. Since this molecular species is enriched in plasmenylcholine these findings suggest that AAG production is likely mediated by phospholipase C-catalyzed hydrolysis of plasmenylcholine. In contrast to ischemia-induced AAG accumulation, DAG content decreased during both control and globally ischemic perfusion intervals. In summary, these findings demonstrate that AAG, in contrast to DAG, accumulates during myocardial ischemia indicating that at least some metabolites of plasmalogen and diacyl phospholipids accumulate at differential rates during myocardial ischemia.
Trends in Health Programs for Workers in Industry
Authors: LEMUEL C. MCGEE
Journal: Annals of Internal Medicine (1963)

Special Article1 January 1963Trends in Health Programs for Workers in IndustryLEMUEL C. MCGEE, PH.D., M.D., F.A.C.P.LEMUEL C. MCGEE, PH.D., M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-1-181 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDuring the westward expansion of America's economic development, employers in lumbering, mining, railroading, or other activities which brought workers into isolated unsettled areas found it necessary to provide medical facilities. In some instances, the employer assumed the cost, in other instances he devised a method of payment by the recipients for the medical care. One such device was the "check-off" for the doctor and the hospital out of each pay envelope. Sawyer (1) stated that the Southern Pacific Railroad in 1868 organized the first major industrial prepayment program for medical care. During subsequent decades, fraternal organizations, lumber and mining companies,...References1. SAWYER WA: Recent sociological trends in medical practice. JAMA 161: 313, 1956. CrossrefMedlineGoogle Scholar2. CUNNINGHAM RM: The Blue Cross Story, Public Affairs Pamphlet No. 101A, Public Affairs Committee, New York, 1958. Google Scholar3. BARNES A: Medical care—a fringe benefit. Industr. Med. Surg. 29: 78, 1960. MedlineGoogle Scholar4. SOMERSSOMERS HMAR: Doctors, Patients and Health Insurance, The Brookings Institution, Washington, D. C., 1961. Google Scholar5. The Extent of Voluntary Health Insurance Coverage in the United States as of December 31, 1959, Health Insurance Council, New York, 1960. Google Scholar6. Source Book of Health Insurance Data, Health Insurance Institute, New York, 1960. Google Scholar7. PRATT RP: What's gone wrong with the blue plans? Med. Economics 38: 201, 1961. Google Scholar8. LEE CM: The challenge of medical care insurance. New Engl. J. Med. 262: 332, 1960. CrossrefMedlineGoogle Scholar9. Hospital Use and Charges by Diagnostic Category, Progress in Health Services, Vol. IX, Health Information Foundation, New York, 1960. Google Scholar10. BROOKS G: Washington Star, January 13, 1959. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Wilmington, DelawareRequests for reprints should be addressed to Lemuel C. McGee, M. D., Hercules Tower, 910 Market Street, Wilmington 99, Delaware. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1963Volume 58, Issue 1Page: 181-188KeywordsHealth care facilitiesHealth economicsPreventive medicineRehabilitation medicine Issue Published: 1 January 1963 PDF DownloadLoading ...
The nonpharmacologic management of the permanent form of junctional reciprocating tachycardia.
Authors: T Guarnieri, W C Sealy, J H Kasell, L D German, J J Gallagher
Journal: Circulation (1984)

The permanent or recurring form of junctional reciprocating tachycardia (PJRT) is an incessant tachycardia that has characteristic clinical and electrophysiologic features of PJRT. Each patient demonstrated near-incessant reciprocating tachycardia with a 1:1 atrioventricular (AV) relationship and with a retrograde P wave (P') occurring closer to the succeeding QRS complexes (i.e., long RP'). With initiation of the tachycardia, there was no prolongation of the PR or AH interval. All patients had evidence of early retrograde atrial activation in their posterior atrial septa and this retrograde limb had properties of decremental conduction. Eight of the nine patients underwent elective surgical ablation of the retrograde limb of tachycardia, and in seven it was successful. Epicardial and endocardial atrial maps recorded during PJRT demonstrated that the site of earliest retrograde activation was in the posterior atrial septum near the coronary sinus orifice. The seven patients in whom surgery was successful left the hospital in sinus rhythm with antegrade conduction, and all are free of tachycardia during the mean follow-up period of 31 months (range 1 to 70 months). In the two remaining patients PJRT was controlled by interruption of the antegrade limb of the tachycardia, the AV node-His bundle. In one patient this was done under direct vision at surgery after an unsuccessful attempt at pathway dissection.(ABSTRACT TRUNCATED AT 250 WORDS)
Effective Control of Staphylococci in a Nursery
Authors: Harold J. Simon, Sumner J. Yaffe, Louis Gluck
Journal: New England Journal of Medicine (1961)

IN the last twenty years, the staphylococcus has replaced the streptococcus as the chief cause of infection in maternity units. Sporadic and epidemic staphylococcal infection among newborn infants now ranks as one of the most serious hazards in the modern nursery (as summarized by Williams et al.1). Previous reports2 3 4 indicate that hexachlorophene-containing compounds applied to newborn infants reduce staphylococcal infections in nurseries and incidentally decrease nasal carriage of staphylococci.The opening of the new Palo Alto—Stanford Hospital Center in the summer of 1959 afforded an opportunity to institute a program centered around the prevention of staphylococcal colonization of the . . .
Daily regimen and compliance with treatment
Authors: B. S Bloom
Journal: BMJ (2001)

Patient compliance—that is, adherence to the regimen of care recommended by the doctor and persistence with it over time—has been a common concern in medical practice for a long time. A search on Medline found nearly 60 000 citations since 1980 related to compliance. Though much is known about the problem and how to overcome it, little seems to have been done in everyday medical practice by healthcare systems and practitioners.

At most, 50% of people with chronic disease comply with their doctor's recommendations, irrespective of disease, treatment, or age.1 Adherence and persistence are poor even among patients with diseases with a high and moderate risk of death.2-4 Many factors related to patients, doctors, and the medical system affect compliance with treatment.2-7 Similar problems exist in all countries. 5 6 Doctors and patients are equally responsible for this abysmal state of affairs.5

The disease …
A Pressor Agent in Human Stable Plasma Protein Solutions
Authors: ROBERT VANDONGEN, RICHARD D. GORDON
Journal: Circulation Research (1968)

A pressor material in human stable plasma protein solutions is described, and evidence that this material may be angiotensin II is presented. When six samples of stable plasma protein solution were assayed against standard angiotensin in the sensitive, ganglioplegic, nephrectomized rat anesthetized with urethane, the levels of pressor activity ranged from 320 to 830 ng/100 ml, with a mean of 552 ng/100 ml. The solution gives a pressor response similar to that of angiotensin II, is heat stable, dialyzable, and destroyed by trypsin and α-chymotrypsin, and reacts with the antibody in a radio-immunoassay for angiotensin II. It is present in sufficient concentration to have significant effects on blood pressure, renal handling of sodium, and aldosterone secretion when infused into patients at rates commonly employed.
Abstract 5711: Applying new light to the detection and treatment of brain cancers using targeted photodynamic therapy
Authors: Joseph D. Meyers, Ann-Marie Broome, Yu Cheng, Richard S. Agnes, Xinning Wang, Malcolm E. Kenney, Clemens Burda, James P. Basilion
Journal: Cancer Research (2012)

Abstract Currently, an estimated 11.4 million people in the US have been affected by cancer and this number is expected to double by 2020 as indicated by the NIH NCI in 2006. Each year approximately 20% of these people are expected to die of cancer, with brain cancers among the most deadly. Brain cancer patients have a median life expectancy of only 6-10 months after diagnosis, and those with recurring brain cancer survive less than 20 weeks after any therapeutic regime. Consequently, there is a critical need to develop and improve the detection, diagnosis, and treatment of brain cancers, including gliomas. Theranostic drugs have the potential to do all of these and are becoming lifesaving alternatives. However, the current standard of care suffers from lack of specificity and systemic toxicity, often requiring invasive surgical procedures. These are significant obstacles when dealing with minimizing offsite damage to the healthy brain while maximizing treatment efficacy in the tumor. Our study presents a novel drug delivery platform using targeted-gold nanoparticles (Au NP) to deliver a therapeutic photodynamic therapy (PDT) drug, phthalocyanine 4 (Pc 4), across the blood-brain tumor barrier (BBTB), which allows both detection and treatment of gliomas within mere hours. Targeting Pc 4 to cancer-specific biomarkers concentrates the drug specifically at the brain tumor, significantly reducing collateral damage to healthy brain tissue. Once Pc 4 is delivered, it offers selectivity based on its defined light activation. Our targeted delivery vehicle possesses several advantages over systemic drug delivery: greater control over bioavailability of the drug, controlled release of Pc 4 directly to the site, lower concentration of drug required for PDT effect, and avoidance of systemic drug exposure. The drug delivery mechanism of targeted-Au NP Pc 4 was investigated utilizing in vivo and in vitro fluorescence imaging, immunohistochemistry, elemental analysis, biodistribution studies, and therapeutic efficacy. We are able to target cancer biomarkers specifically, deliver hydrophobic drugs across the BBTB, increase drug accumulation into the tumor, alter drug localization, and enhance PDT killing affect. As a result, this study presents a unique application of PDT to the treatment of brain tumors using photosensitizing drugs like Pc 4. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5711. doi:1538-7445.AM2012-5711
Medicine and the State
Authors: David W. Wallwork
Journal: JAMA (1963)

Lynch and Raphael, Canadian pathologists, after a brisk, brief description of the "ideal totality that is social medicine" (in the words of Sigerist and Sand), describe the development and present condition of state medicine in Germany, Austria, Russia, Britain, Sweden, and New Zealand. The medical profession's tardiness, fragmentation, political ineptitude, and failure in opposing establishment of socialized systems is plainly outlined. Australia's program of state subsidy of an essentially free enterprise mechanism with minimal governmental control is contrasted with the nationalized systems in other countries. The purpose of the book is to strengthen "the conviction, the resolve and dedication of the (still) free." The book, obviously written from the viewpoint of the medical profession, fur thers its purpose by illustrating how, under state medicine, the cost of medical care mushrooms, the doctor-patient relationship degenerates from one of mutual trust to one of mutual distrust, the doctor's visit degenerates into a
Physical activity is associated with bone geometry of premenarcheal girls in a dose-dependent manner
Authors: Maria Michalopoulou, Antonis Kambas, Diamanda Leontsini, Athanasios Chatzinikolaou, Dimitrios Draganidis, Alexandra Avloniti, Dimitrios Tsoukas, Eleni Michopoulou, Georgios P. Lyritis, Nikolaos Papaioannou, Symeon Tournis, Ioannis G. Fatouros
Journal: Metabolism (2013)
Genomic and Gene Expression Profiling Defines Indolent Forms of Mantle Cell Lymphoma
Authors: Verònica Fernàndez, Olga Salamero, Blanca Espinet, Francesc Solé, Cristina Royo, Alba Navarro, Francisca Camacho, Sílvia Beà, Elena Hartmann, Virginia Amador, Luis Hernández, Claudio Agostinelli, Rachel L. Sargent, Maria Rozman, Marta Aymerich, Dolors Colomer, Neus Villamor, Steven H. Swerdlow, Stefano A. Pileri, Francesc Bosch, Miguel A. Piris, Emili Montserrat, German Ott, Andreas Rosenwald, Armando López-Guillermo, Pedro Jares, Sergi Serrano, Elías Campo
Journal: Cancer Research (2010)

Mantle cell lymphoma (MCL) is typically a very aggressive disease with poor outcomes, but some cases display an indolent behavior that might not necessitate treatment at diagnosis. To define molecular criteria that might permit recognition of such cases, we compared the clinicopathologic features, gene expression, and genomic profile of patients who had indolent or conventional disease (iMCL or cMCL). Patients with iMCL displayed nonnodal leukemic disease with predominantly hypermutated IGVH and noncomplex karyotypes. iMCL and cMCL shared a common gene expression profile that differed from other leukemic lymphoid neoplasms. However, we identified a signature of 13 genes that was highly expressed in cMCL but underexpressed in iMCL. SOX11 was notable in this signature and we confirmed a restriction of SOX11 protein expression to cMCL. To validate the potential use of SOX11 as a biomarker for cMCL, we evaluated SOX11 protein expression in an independent series of 112 cases of MCL. Fifteen patients with SOX11-negative tumors exhibited more frequent nonnodal presentation and better survival compared with 97 patients with SOX11-positive MCL (5-year overall survival of 78% versus 36%, respectively; P = 0.001). In conclusion, we defined nonnodal presentation, predominantly hypermutated IGVH, lack of genomic complexity, and absence of SOX11 expression as qualities of a specific subtype of iMCL with excellent outcomes that might be managed more conservatively than cMCL.
Long-term evaluation of the beneficial effect of subtotal splenectomy for management of hereditary spherocytosis
Authors: Brigitte Bader-Meunier, Frédéric Gauthier, Frédérique Archambaud, Thérèse Cynober, Francoise Miélot, Jean-Paul Dommergues, Josiane Warszawski, Narla Mohandas, Gil Tchernia
Journal: Blood (2001)
Obligations of Medical Schools to Students
Authors: John L. Caughey
Journal: JAMA (1963)

THE YOUNG PEOPLE entering medical schools today are an extraordinarily gifted and able segment of our population. On the average, they rank within the top 10% of their age group in intellectual ability and have performed in a clearly superior manner in a college curriculum more demanding than that of most college students.  There has been a decline in the number of applicants for admission to medical schools in recent years and considerable talk about a decline in their quality. However, the number of applications for the 1963 entering class appears to be 15 to 20% higher than for 1962, and the indications are that there will be a plethora of candidates by 1967 when the large, postwar crop of babies begins to pound on the doors of the medical schools. This will impose on admissions committees the obligation to be even more selective than they are today, with the
Anaemia in Kwashiorkor
Authors: E. B. Adams
Journal: BMJ (1954)

MEDICALJOURNAL. 5'Fifty years later infant mortality, the subject of the London conference in 1906, has been brought under strong control in many countries, and to this massive achievement the new service of education has made an indispensable contribution.But great, difficult, and unfinished tasks of promoting the health of infants and children remain; and these tasks will lie largely in the hands of the child welfare service.
The cortisol response during heart-lung bypass.
Authors: K M Taylor, J V Jones, M S Walker, S Rao, W H Bain
Journal: Circulation (1976)

The response patterns of plasma cortisol and plasma free cortisol have been studied in 20 consecutive patients undergoing cardiac surgery involving the use of heart-lung bypass. Sixteen consecutive patients undergoing closed mitral valvotomy have been used as controls. Total plasma cortisol levels fell at the onset of extracorporeal circulation (ECC) and did not rise significantly throughout the period of ECC. The peak cortisol level in the bypass patients occurred at 24 hours postoperatively with elevated levels still present at 48 hours. This pattern was significantly different from the control patients (P less than 0.001) who exhibited the typical cortisol stress response pattern. Synthetic ACTH stimulation of the adrenal cortex during heart-lung bypass produced a positive response (i.e., a rise in plasma cortisol greater than 7.5 mug/100 ml) in all six patients studied while the six mitral valvotomy patients had no response to synthetic ACTH administration during operation (P less than 0.01). Plasma free cortisol estimations indicate that a rapid and significant rise in % free cortisol occurred at the onset of ECC, but that despite the rise in percentage free, the overall plasma free cortisol concentration (i.e., total plasma cortisol X % free) was significantly lower during ECC in the bypass patients when compared with control (P less than 0.01). Twenty-four hours postoperatively these concentrations were significantly higher in the bypass patients (P less than 0.001).
The Effect of Chromosome 9p21 Variants on Cardiovascular Disease May Be Modified by Dietary Intake: Evidence from a Case/Control and a Prospective Study
Authors: Ron Do, Changchun Xie, Xiaohe Zhang, Satu Männistö, Kennet Harald, Shofiqul Islam, Swneke D. Bailey, Sumathy Rangarajan, Matthew J. McQueen, Rafael Diaz, Liu Lisheng, Xingyu Wang, Kaisa Silander, Leena Peltonen, Salim Yusuf, Veikko Salomaa, James C. Engert, Sonia S. Anand
Journal: PLoS Medicine (2011)

Background One of the most robust genetic associations for cardiovascular disease (CVD) is the Chromosome 9p21 region. However, the interaction of this locus with environmental factors has not been extensively explored. We investigated the association of 9p21 with myocardial infarction (MI) in individuals of different ethnicities, and tested for an interaction with environmental factors. Methods and Findings We genotyped four 9p21 SNPs in 8,114 individuals from the global INTERHEART study. All four variants were associated with MI, with odds ratios (ORs) of 1.18 to 1.20 (1.85×10−8≤p≤5.21×10−7). A significant interaction (p = 4.0×10−4) was observed between rs2383206 and a factor-analysis-derived "prudent" diet pattern score, for which a major component was raw vegetables. An effect of 9p21 on MI was observed in the group with a low prudent diet score (OR = 1.32, p = 6.82×10−7), but the effect was diminished in a step-wise fashion in the medium (OR = 1.17, p = 4.9×10−3) and high prudent diet scoring groups (OR = 1.02, p = 0.68) (p = 0.014 for difference). We also analyzed data from 19,129 individuals (including 1,014 incident cases of CVD) from the prospective FINRISK study, which used a closely related dietary variable. In this analysis, the 9p21 risk allele demonstrated a larger effect on CVD risk in the groups with diets low or average for fresh vegetables, fruits, and berries (hazard ratio [HR] = 1.22, p = 3.0×10−4, and HR = 1.35, p = 4.1×10−3, respectively) compared to the group with high consumption of these foods (HR = 0.96, p = 0.73) (p = 0.0011 for difference). The combination of the least prudent diet and two copies of the risk allele was associated with a 2-fold increase in risk for MI (OR = 1.98, p = 2.11×10−9) in the INTERHEART study and a 1.66-fold increase in risk for CVD in the FINRISK study (HR = 1.66, p = 0.0026). Conclusions The risk of MI and CVD conferred by Chromosome 9p21 SNPs appears to be modified by a prudent diet high in raw vegetables and fruits. Please see later in the article for the Editors' Summary
A neural basis for melanocortin-4 receptor–regulated appetite
Authors: Alastair S Garfield, Chia Li, Joseph C Madara, Bhavik P Shah, Emily Webber, Jennifer S Steger, John N Campbell, Oksana Gavrilova, Charlotte E Lee, David P Olson, Joel K Elmquist, Bakhos A Tannous, Michael J Krashes, Bradford B Lowell
Journal: Nature Neuroscience (2015)