tbuckley/cabot-search huggingface dataset:
Preneoplastic significance of hepatic iron–free foci in genetic hemochromatosis: A study of 185 patients
Authors: Yves M. Deugnier, Paul Charalambous, Daniéle Le Quilleuc, Bruno Turlin, Jeffrey Searle, Pierre Brissot, Lawrie W. Powell, June W. Halliday
Journal: Hepatology (1993)

Sublobular nodules of hepatocytes free of iron or exhibiting much less iron than the surrounding parenchyma, referred to in this study as iron-free-foci, are frequently found in the livers of patients with genetic hemochromatosis complicated by hepatocellular carcinoma. To test the hypothesis that such nodules are preneoplastic lesions, iron-free foci were sought in the initial liver biopsy specimens of 185 patients with untreated and uncomplicated genetic hemochromatosis. Iron-free foci were found in 14 (7.6%) patients, all men, aged from 38 to 76 yr, with heavy iron overload and with fibrosis or cirrhosis. Twelve patients with iron-free foci were followed for 0.9 to 15 yr (7 +/- 6 yr). In six (50%), HCC developed, compared with 2 (8%) from a control group consisting of 24 patients without IFF matched according to age, sex, degree of fibrosis, liver iron amount and follow-up duration. The mean number of iron-free foci per iron-free foci-positive specimen was 3.2 +/- 2.1. Ten patients had dysplastic aspects in their iron-free foci, and four had intrahepatocytic iron-positive inclusions at the periphery of iron-free foci. Proliferative cell nuclear antigen was positive in 75% of iron-free foci and in 24% +/- 21% of hepatocyte nuclei in iron-free foci. This study clearly demonstrates that iron-free foci are proliferative lesions and strongly suggests that such nodules are preneoplastic foci. Therefore the finding of IFF in the initial liver biopsy specimen from a patient with genetic hemochromatosis should lead to regular screening for hepatocellular carcinoma.
Quantitative and qualitative investigation into the impact of focused ultrasound with microbubbles on the triggered release of nanoparticles from vasculature in mouse tumors
Authors: Chung-Yin Lin, Tzu-Ming Liu, Chao-Yu Chen, Yen-Lin Huang, Wei-Kai Huang, Chi-Kuang Sun, Fu-Hsiung Chang, Win-Li Lin
Journal: Journal of Controlled Release (2010)
Palliative Sedation: It's Not a Panacea
Authors: Alexander A. Kon
Journal: The American Journal of Bioethics (2011)

Click to increase image sizeClick to decrease image size Acknowledgments This article is not subject to U.S. Copyright Law. The views expressed are solely those of the author and do not represent the official opinion of the U.S. government, the Department of Defense, or the Department of the Navy.
Reconstructive Surgery of the Eyelids and Ocular Adnexa
Authors: Bradford Cannon
Journal: JAMA (1967)

This new monograph is based partly on the Ophthalmic Plastic Surgery Courses of the American Academy of Ophthalmology and Otolaryngology, and partly on the author's personal experiences in dealing with ophthalmic reconstructive surgical problems. The present volume, the third of a series published by Callahan, is an encyclopedic review of old and modern reconstructive procedures of the eyelids and adnexa.  An unfortunate consequence of the explosion in medical publications is the difficulty of keeping in touch with allied fields. Perusal of the references at the end of each chapter reveals only a few names familiar to the general plastic surgeon. Likewise, references in the plastic surgical literature seldom include many names familiar to the ophthalmic surgeon. This volume should therefore prove valuable to the plastic surgeon anxious to familiarize himself with the ophthalmic literature. At the same time, it will serve as a splendid source of useful information to plastic
1116 A DISPARATE SUBSET OF DOUBLE NEGATIVE T CELLS CONTRIBUTES TO THE OUTCOME OF MURINE FULMINANT VIRAL HEPATITIS VIA EFFECTOR MOLECULE FIBRINOGEN-LIKE PROTEIN 2
Authors: H. Wang, D. Wu, T. Chen, Y. Zou, W. Yan, M. Han, X. Wang, M. Wang, G. Ai, X. Luo, Q. Ning
Journal: Journal of Hepatology (2011)
928. Nonclinical Safety Study of Direct Myocardial Injection of pVGI.1 (VEGF2) Using the StilettoTM Endocardial Direct Injection Catheter System in a Swine Model
Authors: Qing Wang, Robert Rapoza, Wendy Naimark, Hsing-Yi Jan, Yawen L. Chiang
Journal: Molecular Therapy (2005)

Intramyocardial delivery of vascular endothelial growth factor-C (VEGF-2) has shown physiological and anatomic evidence of angiogenesis in animal models and clinical trials for myocardial ischemia. We evaluated safety and histopathological toxicity of multiple intramyocardial injections of DNA plasmid encoding vascular endothelial growth factor C, pVGI.1 (VEGF2) via the Boston Scientific Stiletto|[trade]| Endocardial Direct Injection System (Stiletto|[trade]|) in normal Yorkshire swine.
Single-Patient Rooms for Safe Patient-Centered Hospitals
Authors: Michael E. Detsky
Journal: JAMA (2008)

1. Food and Drug Administration. Developing guidance on conducting scientifically sound pharmacoepidemiologic safety studies using large electronic healthcare data sets: public workshop: request for comments. Fed Regist. 2008;73 (79):21963-21964. 2. Food and Drug Administration. The Sentinel Initiative: national strategy for monitoring medical product safety. http://www.fda.gov/oc/initiatives/advance/reports /report0508.pdf. Accessed July 17, 2008. 3. Misbin RI. Medical office review of Avandia: application number: 021071: Center for Drug Evaluation and Research. http://oversight.house.gov/story.asp?ID= 1325. Accessed July 17, 2008. 4. Kahn SE, Haffner SM, Heise MA, et al; ADOPT Study Group. Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy. N Engl J Med. 2006; 355(23):2427-2443. 5. Gerstein HC, Yusuf S, Bosch J, et al. Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: a randomised controlled trial. Lancet. 2006;368(9541):1096-1105. 6. Home PD, Pocock SJ, Beck-Nielsen H, et al. Rosiglitazone Evaluated for Cardiac Outcomes and Regulation of Glycemia in Diabetes (RECORD) Study: interim findings on cardiovascular hospitalizations and deaths. N Engl J Med. 2007; 357(1):28-38. 7. Nissen SE, Wolski K. Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. N Engl J Med. 2007;356(24):2457-2472. 8. Vandenbroucke J. Observational research, randomised trials, and two views of medical science. PLoS Med. 2008;5:e67; supplemental material. http://medicine .plosjournals.org/archive/1549-1676/5/3/supinfo/10.1371_journal.pmed.0050067 .sd001.pdf. 9. Joffe HV, Parks M, Meyer R, Jenkins J, Temple R. Rosiglitazone and the FDA. N Engl J Med. 2007;357(17):1775-1776. 10. Psaty BM, Ray W. FDA guidance on off-label promotion and the state of the literature from sponsors. JAMA. 2008;299(16):1949-1951. 11. Food and Drug Administration Amendments Act of 2007. HR 3580, enacted by the House and Senate, Pub L No. 110-85. http://frwebgate.access.gpo.gov /cgi-bin/getdoc.cgi?dbname=110_cong_billsd147(8):573-577. 13. Rossouw JE; Writing Group for the Women’s Health Initiative. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women’s Health Initiative randomized controlled trial. JAMA. 2002; 288(3):321-333. 14. ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. Major outcomes in moderately hypercholesterolemic, hypertensive patients randomized to pravastatin vs usual care: the Antihypertensive and LipidLowering Treatment to Prevent Heart Attack Trial (ALLHAT-LLT). JAMA. 2002; 288(23):2998-3007. 15. Gerstein HC; Action to Control Cardiovascular Risk in Diabetes Study Group. Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med. 2008; 358(24):2545-2559.
Sexually Transmitted Diseases: Guide to Diagnosis and Therapy
Authors: Jerry D. Smilack
Journal: JAMA (1986)

The recent profusion of books on sexually transmitted diseases reflects the increasing number of conditions thought to be transmitted sexually. In the not-too-distant past, five or six diseases constituted the core of the subject. Now, that list includes<i>Gardnerella vaginalis and Giardia lamblia</i>infection, as well as actinomycosis and the acquired immunodeficiency syndrome. Keeping up with the latest diagnostic techniques and therapy can be a challenge. In the preface, the author states that the volume is a handbook for physicians, house staff, and clinic personnel, meant to provide the practitioner with relevant information. In other words, the book is practical. In the inch of text between its covers is crammed a wealth of information, current (this is the third edition) and concise. The format of the book is straightforward. Each chapter is devoted to the diseases produced by a single pathogen. For the reader lacking a specific etiologic diagnosis (urethritis
Accidental Acute Whole-Body Gamma Irradiation of Seven Clinically Well Persons
Authors: James B. McCandless
Journal: JAMA (1965)

Six Puerto Ricans, including two women, and a Chinese-American man were accidentally exposed to acute wholebody gamma radiation from 4 to 100 roentgens (r). Their case histories show no serious morbidity. Various white blood cell variations were present. At an exposure of 18 r and more, a neutrophilia and lymphopenia occurred about the fourth day. A daily plot of the neutrophils and lymphocytes would be of diagnostic value in future instances.
Paratyphoid A Fever
Authors: M. F. A. Wahab, R. P. Robertson, F. O. Raasch
Journal: Annals of Internal Medicine (1969)

Paratyphoid A fever was studied in 41 adolescent parents who had been febrile approximately 1 week before admission and only 1 of whom had ever been immunized with a salmonella vaccine. Clinical evaluation agreed with the classical description of paratyphoid fever except for a scarcity of rose spots. Leukocyte counts and Widal reactions afforded minimal diagnostic aid, but bone marrow and multiple blood cultures were valuable. Seven patients were concomitantly infected with Schistosoma species, but this did not influence their clinical courses. In vitro, Salmonella paratyphi A strains were generally more sensitive to ampicillin than to chloramphenicol. Chloramphenicol, ampicillin, and both drugs given simultaneously were used in treatment. The mean afebrile days of the respective drug groups were 5.0, 5.8, and 5.9. There was a 21% treatment failure rate with ampicillin, an 8% relapse rate with chloramphenicol, but no therapeutic shortcomings in the combined-therapy group. Steroids were needed in only one instance, and there were no complications, deaths, or development of the carrier state.
Autoimmune Diseases in Asthma
Authors: Amir Tirosh, Dror Mandel, Francis B. Mimouni, Eyal Zimlichman, Tzippora Shochat, Ilan Kochba
Journal: Annals of Internal Medicine (2006)

Previous research has suggested an inverse relationship between T-helper 2-related atopic disorders, such as asthma, and T-helper 1-related autoimmune diseases. One controversial hypothesis postulates that asthma provides a protective effect for the development of autoimmune-related disorders.To assess the rate of newly diagnosed autoimmune disorders in a large cohort of young adults.Using cross-sectional data from the Israeli Defense Force database, the authors analyzed the prevalence of autoimmune disorders in asthmatic and nonasthmatic military personnel between 1980 and 2003. A follow-up study traced newly diagnosed autoimmune disorders among asthmatic and nonasthmatic individuals from the time of enrollment in military service until discharge (22 and 36 months for women and men, respectively).General community.307,367 male and 181,474 female soldiers in compulsory military service who were between 18 and 21 years of age.Cases of type 1 diabetes mellitus, vasculitis, immune thrombocytopenic purpura, inflammatory bowel disease, rheumatoid arthritis, and the antiphospholipid syndrome.Of 488,841 participants at enrollment, significantly more women than men had autoimmune disorders. Compared with asthmatic women, nonasthmatic women had a significantly higher prevalence of all autoimmune disorders except for the antiphospholipid syndrome. Type 1 diabetes mellitus, vasculitis, and rheumatoid arthritis were less prevalent in men with asthma than in those without. During the follow-up period, vasculitis and rheumatoid arthritis were more frequently diagnosed in nonasthmatic persons of both sexes. There was a significantly higher incidence of immune thrombocytopenic purpura, inflammatory bowel disease, and the antiphospholipid syndrome in nonasthmatic women and a statistically significantly higher incidence of type 1 diabetes mellitus in nonasthmatic men.The study was limited to a population of young military recruits; therefore, its findings are not necessarily applicable to the general population. Because of the noninterventional nature of the study, it describes associations but cannot prove causality.Asthma status may affect the prevalence of major autoimmune disorders. Preexisting asthma seems to protect against the development of autoimmune disorders to varying degrees in men and women.
Occupational Medicine in the International Workplace
Authors: James J. Andonian
Journal: JAMA (1992)

The back cover of this text proclaims it as a "vital resource for occupational physicians and nurses, personnel directors, safety engineers, and health care planners." Upon completing my review, I found myself contesting this claim. The author actually has attempted to cover a broadly diverse topic and has targeted an equally diverse reading audience. A clue is the glossary for nonmedical users, three pages long with 49 terms! The net result is a colloquial text that is full of anecdotes, loosely edited, and lacking depth of medical or administrative insight. The attempt to accommodate a lay and medical audience just doesn't work here, and I believe the text will come across as trivial to the trained occupational nurse or physician. The same might apply for the health care professional not active in occupational health. On the other hand, it may have some merit for the personnel administrator and, possibly, the
Two acute monocytic leukemia (AML-M5a) cell lines (MOLM-13 and MOLM-14) with interclonal phenotypic heterogeneity showing MLL-AF9 fusion resulting from an occult chromosome insertion, ins(11;9)(q23;p22p23)
Authors: Y Matsuo, RAF MacLeod, CC Uphoff, HG Drexler, C Nishizaki, Y Katayama, G Kimura, N Fujii, E Omoto, M Harada, K Orita
Journal: Leukemia (1997)
A new device for the efficient pulverisation and extraction of myocardial biopsies for high energy phosphate analysis
Authors: E. H SPEIR, J. SULLIVAN, R. E PATTERSON
Journal: Cardiovascular Research (1985)

Journal Article A new device for the efficient pulverisation and extraction of myocardial biopsies for high energy phosphate analysis Get access EDITH H SPEIR, EDITH H SPEIR From the Section of Experimental Physiology and Pharmacology, Cardiology Branch, National Heart, Lung, and Blood Institute and Biomedical Engineering and Instrumentation Branch, Division of Research Services †Address all correspondence and reprint requests to: Edith H Speir, BS, Cardiology Branch, Bld 10, Room 7B-15, National Institutes of Health, Bethesda, dryland 20205, USA. Tel: (301) 496-1421. Search for other works by this author on: Oxford Academic PubMed Google Scholar JAMES SULLIVAN, JAMES SULLIVAN From the Section of Experimental Physiology and Pharmacology, Cardiology Branch, National Heart, Lung, and Blood Institute and Biomedical Engineering and Instrumentation Branch, Division of Research Services Search for other works by this author on: Oxford Academic PubMed Google Scholar RANDOLPH E PATTERSON RANDOLPH E PATTERSON From the Section of Experimental Physiology and Pharmacology, Cardiology Branch, National Heart, Lung, and Blood Institute and Biomedical Engineering and Instrumentation Branch, Division of Research Services Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 19, Issue 7, July 1985, Pages 449–451, https://doi.org/10.1093/cvr/19.7.449 Published: 01 July 1985
Castor-Oil in Neuralgia.
Authors: Wickes Washburn
Journal: JAMA (1900)

New York City, April 26, 1900. <h3>To the Editor:</h3> —In the discussion on castor-oil in the treatment of neuralgia, I note (seeThe Journalof April 21, p. 982) that Dr. Paddock is troubled to know how the oil can be given, while Dr. Fütterer tells of giving it with alcoholics that may in some degree interfere with its usefulness; and Dr. Hirst is quoted as advising that it be given in<i>warm</i>milk, while the question is raised as to how warm milk disguises the taste of the oil. Some fifteen years ago I not only gave to the profession the fact that<i>cold</i>milk is the best of all vehicles in which to administer both castor-oil and cod-liver oil, but also pointed out the method of administration with the reasons for the method used. Milk, like these two oils, is an oil or, more properly speaking, an emulsion—and
AB0230 Pre-methotrexate lung screening for interstitial lung disease – is a chest x-ray adequate?
Authors: I. Al-Shakarchi, B. Lobão, C. Henriques, S. Steer, P. Gordon, K. Irving
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Methotrexate (MTX) is the most commonly used disease modifying anti-rheumatic drug (DMARD) for the treatment of rheumatoid arthritis (RA). Methotrexate pneumonitis (MP) is a potentially fatal hypersensitivity reaction with a mortality rate of ∼20%, the risk being maximal in the first year of treatment. The incidence of MP is higher in patients with pre-existing lung disease, particularly interstitial lung disease (ILD). Early identification of these patients provides the opportunity to offer an alternative agent. Prior to commencing MTX the current British Society for Rheumatology guidelines advise a screening chest radiograph (CXR). CXR has a low sensitivity for detecting ILD and it has been suggested that carbon monoxide transfer factor (TLCO) is a more sensitive marker. The guideline of the Rheumatology department at King's College Hospital is to request a pulmonary function test (PFT) as well as a CXR prior to commencing MTX in all RA patients. If the TLCO is abnormal a high-resolution computerised tomography scan (HRCT) is considered. <h3>Objectives</h3> To investigate whether screening with PFT and CXR identifies more patients with ILD than screening with CXR alone. <h3>Methods</h3> 107 MTX-naive RA patients aged 21–86 who had previously had CXR and PFT were identified from the hospital database. Those patients with an abnormal TLCO (defined as ≤79% in non-smokers and ≤69% in smokers) who had undergone HRCT were included. Where ILD was identified on HRCT, the CXR was reviewed for abnormalities. <h3>Results</h3> Of the 107 patients, 44 with normal TLCO were excluded and a further 23 patients were excluded as they had not had HRCT. Of the 40 remaining patients, ILD was identified in 12 (see Table) of whom 6 (50%) had a normal CXR. 9 (75%) patients had early RA, defined as within 3 years of symptom onset. Of the 6 patients with abnormal CXR, 5 had TLCO &lt;49% indicating advanced lung disease. <h3>Conclusions</h3> Our results show that the combination of CXR and PFT detects more patients with RA ILD compared to CXR alone, particularly in less advanced respiratory disease. In this cohort of RA patients undergoing pre-MTX screening we identified 12 patients with ILD, a prevalence of 11%. 50% of these patients would not have been identified by screening with CXR alone. MP is a rare but potentially fatal side-effect of MTX treatment. It is well recognized that prognosis is significantly worse in RA patients with ILD. Therefore we suggest early screening with PFT to identify these patients, allowing appropriately tailored management. <h3>References</h3> <b>Disclosure of Interest</b>: None Declared
ELECTROENCEPHALOGRAPHY IN SCHIZOPHRENIA
Authors: KNOX H. FINLEY, C. MACFIE CAMPBELL
Journal: American Journal of Psychiatry (1941)

1. The EEG. tracings from 500 schizophrenic patients are compared with the records from 215 normal controls. A significantly greater percentage of borderline and abnormal records was found in the schizophrenic patients. 2. A greater percentage of the abnormal records in the schizophrenic patients was found in the catatonic-hebephrenic group. 3. There is nothing consistent or diagnostic in the character of the EEG. tracings of schizophrenic patients, a great variety of records being obtained. Rapid activity is common but is not of diagnostic significance because similar activity is found in other neuropsychiatric disorders, particularly in the manic-depressives, agitated depressions of middle age and in neurosyphilitics. 4. Our studies show no significant relationship between schizophrenia and epilepsy on the basis of the EEG. patterns. 5. With the psychoses an expression of the dynamic forces of the total personality including those of both biological and psychological origin, we feel that the EEG. will prove to be a valuable measure of the basic biological forces playing a part in the schizophrenic disorders.
In-111 Oxine Autologous Labeled Platelets in the Diagnosis of Kidney Graft Rejection
Authors: J MARTIN-COMIN, M ROCA, J M GRINO, C PARADELL, C CARALPS
Journal: Clinical Nuclear Medicine (1983)

The usefulness of ln-111 oxine labeled autologous platelets in the diagnosis of renal graft rejection was studied. The method is based on imaging of the graft area at 4, 24, 48, and 72 hours after the injection of the labeled cells. The study was done in 31 renal transplant recipients. The control group included four patients with normal renal function without evidence of rejection. No platelet uptake was observed in any of them. The study group included 22 patients with acute rejection which was confirmed histologically in 13. One case of chronic vascular type rejection of the graft tracer uptake was seen. There was a false-positive result due to a perirenal hematoma. In three patients with a nonimmunological sudden impairment of renal function, no activity was detected in the graft area. We also evaluated the changes in platelet trapping throughout the study and they seemed to correlate with the response to the antirejection therapy.
Targeting Fel d 1 to FcγRI induces a novel variation of the TH2 response in subjects with cat allergy
Authors: Kathryn E. Hulse, Amanda J. Reefer, Victor H. Engelhard, Shama M. Satinover, James T. Patrie, Martin D. Chapman, Judith A. Woodfolk
Journal: Journal of Allergy and Clinical Immunology (2007)
Mechanisms of Digitalis Toxicity
Authors: MICHAEL R. ROSEN, HENRY GELBAND, CHARLES MERKER, BRIAN F. HOFFMAN
Journal: Circulation (1973)

Microelectrode technics were used to study effects of ouabain (O), 2x10 –7 moles/liter, on phase 4 of Purkinje fiber (PF) transmembrane potentials (TMP). Perfusion for 25-35 min with O caused an increase in phase 4 depolarization which resulted in either increased automaticity or occurrence of low-amplitude potentials (LAP). Increased automaticity was more frequent when PF had been stretched, when [K + ] o = 2.5 mmoles/liter, and when O caused a marked decrease in resting membrane potential (RMP). LAP occurred at all [K + ] o (2.5, 4.0, and 5.0 mmoles/liter), and were the typical response of unstretched fibers in which RMP had not decreased markedly. The magnitude of the LAP increased at [K + ] o = 4.0 mmoles/liter and at faster stimulus rates. Threshold potential (TP) was decreased to a slightly greater extent than RMP. Although LAP did not result in spontaneous action potentials, superimposition of subthreshold depolarizations on LAP resulted in excitation. Whether O-induced increases in phase 4 slope result in automaticity or LAP depends on interrelationships between RMP, TP, and level of membrane potential reached during phase 4. Although hearts developing LAP due to digitalis toxicity may not demonstrate increased automaticity, the presence of phase 4 depolarization in the form of LAP may cause an impairment of conduction which is dependent on cycle length.