tbuckley/cabot-search huggingface dataset:
Skin Autofluorescence as a Noninvasive Marker of Vascular Damage in Patients With Type 2 Diabetes
Authors: Helen L. Lutgers, Reindert Graaff, Thera P. Links, Lielith J. Ubink-Veltmaat, Henk J. Bilo, Rijk O. Gans, Andries J. Smit
Journal: Diabetes Care (2006)

Advanced glycation end products (AGEs) are thought to have a role in the pathogenesis of diabetes complications. We recently reported the association between skin autofluorescence, as a measure of tissue AGE accumulation, and diabetic neuropathy in a selected diabetic population. In this study, we investigated the relation between skin autofluorescence and clinical variables including micro- and macrovascular complications in a type 2 diabetes primary care population.Clinical data and skin autofluorescence were obtained in the type 2 diabetes group (n = 973) and in a control group (n = 231). Skin autofluorescence was assessed by illumination of the lower arm with a fluorescent tube (peak intensity approximately 370 nm).Skin autofluorescence was significantly higher in type 2 diabetic patients compared with control subjects in each age category. Multiple regression analysis showed significant correlation of skin autofluorescence with age, sex, diabetes duration, BMI, smoking, HbA1c, plasma creatinine, HDL cholesterol, and albumin-to-creatinine ratio in the type 2 diabetes group (R2 = 25%) and with age and smoking in the control group (R2 = 46%). Skin autofluorescence was significantly higher in the type 2 diabetes group, with both micro- and macrovascular disease, compared with the group without complications and the group with only microvascular complications.This study confirms in a large group of type 2 diabetic patients that skin autofluorescence is higher compared with age-matched control subjects and is associated with the severity of diabetes-related complications. Skin autofluorescence reflecting vascular damage might be a rapid and helpful tool in the diabetes outpatient clinic for identifying diabetic patients who are at risk for developing complications.
Psychosocial and Socioeconomic Risk Factors for Premature Death in Young People With Type 1 Diabetes
Authors: Susan P. Laing, Michael E. Jones, Anthony J. Swerdlow, Andrew C. Burden, Wendy Gatling
Journal: Diabetes Care (2005)

OBJECTIVE—Mortality from acute diabetes-related events is greatly raised in young adults with type 1 diabetes. Psychosocial and socioeconomic risk factors are examined for deaths from acute events separately from deaths due to other causes. RESEARCH DESIGN AND METHODS—This study had a nested case-control design. The cases were patients from the Diabetes UK cohort who died before age 40 years. Deaths were categorized as acute events or chronic conditions related to diabetes. Where possible, two matched control subjects were selected for each case. Data relating to psychosocial and socioeconomic factors and variables related to diabetes complications were extracted from the case notes. Risks of death were estimated by calculation of odds ratios (ORs). RESULTS—Case notes were obtained for 98 case and 137 control subjects. Fifty-one deaths were attributed to acute causes, 34 to chronic conditions related to diabetes, and the remaining 13 were unrelated to diabetes. Living alone (OR 4.4), past drug abuse (5.7), and previous psychiatric referral (4.6) were all significantly associated with death from acute events but not death from chronic conditions. There was no association between deaths from acute events and nephropathy, hypertension, neuropathy, or retinopathy, although all of these were associated with deaths from chronic conditions. CONCLUSIONS—The results indicate that psychosocial factors are powerful risk factors for mortality from acute events in patients with type 1 diabetes, although not for mortality from chronic conditions. The data enable the identification of a high-risk group suitable for targeting with preventive measures to reduce acute event mortality.
Long-term Follow-up and Survival of Patients Following a Recurrence of Melanoma After a Negative Sentinel Lymph Node Biopsy Result
Authors: Edward L. Jones, Teresa S. Jones, Nathan W. Pearlman, Dexiang Gao, Robert Stovall, Csaba Gajdos, Nicole Kounalakis, Rene Gonzalez, Karl D. Lewis, William A. Robinson, Martin D. McCarter
Journal: JAMA Surgery (2013)

To analyze the predictors and patterns of recurrence of melanoma in patients with a negative sentinel lymph node biopsy result.Retrospective chart review of a prospectively created database of patients with cutaneous melanoma. SETTING Tertiary university hospital.A total of 515 patients with melanoma underwent a sentinel lymph node biopsy without evidence of metastatic disease between 1996 and 2008.Time to recurrence and overall survival.Of 515 patients, 83 (16%) had a recurrence of melanoma at a median of 23 months during a median follow-up of 61 months (range, 1-154 months). Of these 83 patients, 21 had melanoma that metastasized in the studied nodal basin for an in-basin false-negative rate of 4.0%. Patients with recurrence had deeper primary lesions (mean thickness, 2.7 vs 1.8 mm; P < .01) that were more likely to be ulcerated (32.5% vs 13.5%; P < .001) than those without recurrence. The primary melanoma of patients with recurrence was more likely to be located in the head and neck region compared with all other locations combined (31.8% vs 11.7%; P < .001). Median survival following a recurrence was 21 months (range, 1-106 months). Favorable characteristics associated with lower risk of recurrence included younger age at diagnosis (mean, 49 vs 57 years) and female sex (9% vs 21% for males; P < .001).Overall, recurrence of melanoma (16%) after a negative sentinel lymph node biopsy result was similar to that in previously reported studies with an in-basin false-negative rate of 4.0%. Lesions of the head and neck, the presence of ulceration, increasing Breslow thickness, older age, and male sex are associated with increased risk of recurrence, despite a negative sentinel lymph node biopsy result.
Psychiatric Comorbidity in Pedophilic Sex Offenders
Authors: Nancy C. Raymond, Eli Coleman, Fred Ohlerking, Gary A. Christenson, Michael Miner
Journal: American Journal of Psychiatry (1999)

The primary purpose of this research was to assess the rates of axis I and axis II psychiatric disorders, as defined in DSM-IV, in a group of pedophilic sex offenders.Forty-five male subjects with pedophilia who were participating in residential or outpatient sex offender treatment programs were recruited to participate. Subjects were interviewed by using the Structured Clinical Interview for DSM-IV.Ninety-three percent of the subjects (N = 42) met the criteria for an axis I disorder other than pedophilia. The lifetime prevalence of mood disorder in this group was 67%. Sixty-four percent of the subjects met the criteria for an anxiety disorder, 60% for psychoactive substance use disorder, 53% for another paraphilia diagnosis, and 24% for a sexual dysfunction diagnosis.Axis I and II comorbidity rates are high in this population. Untreated comorbid psychiatric disorders may play a role in treatment failure and recidivism.
Phase 1b Study of Motesanib, an Oral Angiogenesis Inhibitor, in Combination with Carboplatin/Paclitaxel and/or Panitumumab for the Treatment of Advanced Non–Small Cell Lung Cancer
Authors: George R. Blumenschein, Karen Reckamp, G. Joe Stephenson, Timothy O'Rourke, Gregory Gladish, Jesse McGreivy, Yu-Nien Sun, Yining Ye, Mandy Parson, Alan Sandler
Journal: Clinical Cancer Research (2009)

Motesanib is a small-molecule antagonist of vascular endothelial growth factor receptor 1, 2, and 3, platelet-derived growth factor receptor, and Kit. This phase 1b study assessed the safety, maximum tolerated dose (MTD), and pharmacokinetics, and explored the objective response of motesanib plus carboplatin/paclitaxel and/or the fully human anti-epidermal growth factor receptor monoclonal antibody panitumumab in advanced non-small cell lung cancer (NSCLC).Patients with unresectable NSCLC received sequentially escalating doses of motesanib [50, 125 mg once daily; 75 mg twice daily] orally continuously plus carboplatin/paclitaxel (arm A; first line) or panitumumab (arm B; first and second line) once every 21-day cycle or 125 mg once daily plus carboplatin/paclitaxel and panitumumab (arm C; first line).Forty-five patients received motesanib. Three dose-limiting toxicities occurred: grade 4 pulmonary embolism (n = 1; arm A, 50 mg once daily) and grade 3 deep vein thrombosis (n = 2; arm A, 125 mg once daily; arm C). The MTD was 125 mg once daily. Common motesanib-related adverse events were fatigue (60% of patients), diarrhea (53%), hypertension, (38%), anorexia (27%), and nausea (22%). Three cases of cholecystitis occurred but only in the 75-mg twice-daily schedule, which was subsequently discontinued. At 125 mg once daily, motesanib pharmacokinetics were not markedly changed with carboplatin/paclitaxel coadministration; however, exposure to paclitaxel was moderately increased. The objective response rates were 17%, 0%, and 17% in arms A, B, and C, respectively.Treatment with motesanib was tolerable when combined with carboplatin/paclitaxel and/or panitumumab, with little effect on motesanib pharmacokinetics at the 125-mg once daily dose level. This dose is being investigated in an ongoing phase 3 study in NSCLC.
IL-1β and IL-6 Levels and Sleep Patterns in HIV-Infected Children with Viremia
Authors: S.B. Foster, M.E. Paul, D.G. Glaze, J.M. Reuben, L.L. Harris, E.N. Cohen, B. Lee, C.A. Kozinetz, H.L. Schwarzwald, M.W. Kline, C.D. Jackson, E.N. Ward, J.E. Fehlis, P.Y. Brouwers, T.L. Miller, L. Himic, D.F. Armstrong, A.A. Colin, G.B. Scott, S. Shahzeidi, D. Asthana, S.E. Lipshultz, W.T. Shearer
Journal: Journal of Allergy and Clinical Immunology (2008)
Impact of free on-site vaccine and/or healthcare workers training on hepatitis B vaccination acceptability in high-risk subjects: a pre-post cluster randomized study
Authors: O. Launay, Y. Le Strat, W. Tosini, L. Kara, S. Quelet, S. Lévy, J. Danan, J. Réveillon, J. Houdayer, E. Bouvet, D. Lévy-Bruhl
Journal: Clinical Microbiology and Infection (2014)
Hypersensitivity to trimethoprim
Authors: M. D. Alonso, C. Marcos, I. Davila, B. de la Hoz, J. A. Martin, F. Parra, M. L. Diez
Journal: Allergy (1992)

We present two patients who experienced life‐threatening immediate reactions and one patient who developed generalized urticaria following oral administration of trimethoprim (TMP) and sulfamethoxazole (SMX) combination. Skin prick tests with TMP were positive in the three patients. No patients reacted to skin prick tests with SMX. No significant levels of IgE antibodies to TMP were found by RAST in the serum of the patients. Normal subjects used as controls did not react to any of these tests. Single‐blind, placebo‐controlled oral challenges were positive with TMP and negative with SMX in all patients. These results suggest that the three patients developed type I hypersensitivity reactions to TMP. In our patients skin prick tests with TMP were useful in TMP hypersensitivity diagnosis.
Three-dimensional vaginal sonography in obstetrics and gynaecology
Authors: R. Maymon
Journal: Human Reproduction Update (2000)

Great strides have recently been made in obstetrics and gynaecology secondary to the development of high-performance transvaginal ultrasound (TVS) instruments. However, even this advanced technology can provide only two-dimensional (2D) views of three-dimensional (3D) structures. Although an experienced examiner can easily piece together sequential 2D planes for creating a mental 3D image, individual sectional planes cannot be achieved in a 2D image because of various difficulties. Today, 3D TVS can portray not only individual image planes, it can also store complex tissue volumes which can be digitally manipulated to display a multiplanar view, allowing a systematic tomographic survey of any particular field of interest. The same technology can also display surface rendering and transparency views to provide a more realistic 3D portrayal of various structures and anomalies. The current review provides examples and discussions of the various applications in obstetrics, gynaecology and assisted reproduction in which 3D TVS is a useful supplement to image modality.
Isolation of a nuclease-resistant decoy RNA that selectively blocks autoantibody binding to insulin receptors on human lymphocytes.
Authors: S W Lee, B A Sullenger
Journal: The Journal of Experimental Medicine (1996)

An RNA containing 2'-amino pyrimidines has been isolated using in vitro selection techniques that specifically and avidly (apparent Kd approximately 30 nM) binds a mouse monoclonal antibody called MA20. This 2'-amino-derivatized RNA is at least 10,000-fold more stable than unmodified RNA in serum, and can act as a decoy and block MA20 binding to its natural antigen, the human insulin receptor, on lymphocytes. Furthermore, this RNA decoy can inhibit MA20-mediated downmodulation of insulin receptor expression on human lymphocytes in culture by up to 90%. Surprisingly, the decoy RNA cross-reacts with autoantibodies from patients with extreme insulin resistance and can inhibit these antiinsulin receptor antibodies from downmodulating insulin receptor expression by up to 80% without impeding insulin binding to its receptor. These results suggest that in vitro-selected decoy RNAs may be able to specifically and selectively block oligoclonal autoimmune responses to self-antigens in patients with autoimmune diseases.
A Case of Cytomegalic Inclusion Disease
Authors: T. M. Vanier
Journal: Thorax (1960)

Reported cases of cytomegalic inclusion disease in which the diagnosis was made during life are uncommon.I have been able to trace reports of only four cases in which subsequent development has been normal or near normal (Gallager, 1952; Birdsong, Smith, Mitchell, and Corey, 1956; McElfresh and Arey, 1957).It now seems established that the characteristic cells associated with the disease and first described in 1904 by Ribbert (Seifert and Oehme, 1958) are the result of infection by the salivary gland virus, so named because of the frequency of its finding in human salivary tissue.Similar cellular changes have been noted in the salivary glands of laboratory and other animals and a possible spontaneous disseminated form of the disease has been reported in guinea-pigs (Pappenheimer and Slanetz, 1942).The viruses producing these changes seem to be strictly species specific, and it was not until 1956 that Smith and also Weller, Macauley, Craig, and Wirth isolated the virus from the organs of children dying from the disease, by transmission in tissue culture of human fibroblasts.In the same year Rowe, Hartley, Waterman, Turner, and Huebner were able to demonstrate complement fixing and neutralizing antibody against this or an almost identical virus in human sera.For over 50 years numerous reports have appeared describing the characteristic cells in nearly every organ and tissue of the body at necropsy.Generally
Relationship Between Deficits in Overall Quality of Life and Non–Small-Cell Lung Cancer Survival
Authors: Jeff A. Sloan, Xinghua Zhao, Paul J. Novotny, Jason Wampfler, Yolanda Garces, Matthew M. Clark, Ping Yang
Journal: Journal of Clinical Oncology (2012)

Purpose Evidence has suggested a clinically meaningful relationship between self-reported quality of life (QOL) of a patient with cancer at the time of receiving a cancer diagnosis and overall survival (OS). This study evaluated the prognostic value of QOL assessments with regard to OS in a large cohort of patients with lung cancer. Patients and Methods A total of 2,442 patients with non–small-cell lung cancer were observed between 1997 and 2007 and completed a single-item measure of overall QOL within the first 6 months of receiving a lung cancer diagnosis; these were dichotomized using an a priori definition of a clinically deficient score (CDS; ≤ 50 v &gt; 50). Kaplan-Meier estimates and Cox models were used to evaluate the prognostic importance of QOL on OS alone and in the presence of covariates. Logistic regression modeling was used to identify which clinical and patient characteristics were related to a clinically meaningful deficit in QOL. Results QOL deficits at time of lung cancer diagnosis were significantly associated with OS (hazard ratio [HR], 1.55; P &lt; .001), as were performance status, older age, smoking history, male sex, treatment factors, and stage of disease. The median survival for patients with CDS QOL was 1.6 years versus 5.6 years for patients with non-CDS QOL. After controlling for all these covariates, the indication of a clinically deficient baseline QOL still contributed significantly to the prediction of patient survival (HR, 0.67; P &lt; .001). Conclusion Overall QOL measured by a simple single item at the time of lung cancer diagnosis is a significant and independent prognostic factor for survival in patients with lung cancer.
No-Reflow Phenomenon
Authors: Shereif H. Rezkalla, Robert A. Kloner
Journal: Circulation (2002)

B ecause total coronary artery occlusion was found in the early hours of transmural myocardial infarction, most of our research interest and treatment strategies focus on epicardial coronary arteries. 1Little attention, however, is paid to the coronary microvasculature.When a coronary artery is occluded, detrimental changes occur in the cardiac capillaries and arterioles.After relief of the occlusion, blood flow to the ischemic tissue may still be impeded, a phenomenon known as no reflow.This article attempts to provide an in-depth understanding of this phenomenon from the laboratory bench to the clinical arena.
Autoantibodies in chronic graft versus host result from cognate T-B interactions.
Authors: S C Morris, R L Cheek, P L Cohen, R A Eisenberg
Journal: The Journal of Experimental Medicine (1990)

A chronic graft-versus-host reaction (GVH) induced in nonautoimmune mice causes a syndrome that closely resembles SLE. In this model, donor T cells react against incompatible host Ia structures and generate excessive help, which activates a subpopulation of self-reactive B cells. We have studied whether these self-reactive B cells are activated by direct interaction with alloreactive T cells or by nonspecific bystander effects. Two types of chimeras were made: double-parental chimeras, differing at both Ia and Igh allotype [B6.C20 + bm12----(B6.C20 x bm12)F1]; and control chimeras [(B6.C20 x bm12)F1----(B6.C20 x bm12)F1]. A chronic GVH syndrome was induced in the chimeras by infusion of B6 or bm12 spleen cells. Coombs and antichromatin autoantibodies were measured using Igh allotype-specific immunoassays. The double-parental chimeras that received bm12 cells made autoantibodies principally of the Igha allotype, indicating that the bm12 T cells interacted only with the Iab-bearing host B cells. Conversely, double-parental chimeras that received B6 cells made mostly Ighb autoantibodies, indicating direct cognate interaction with the Iabm12-bearing host B cells. The control chimeras made autoantibodies of both allotypes. These results indicate that autoantibodies in chronic GVH result from direct T-B interactions and not from nonspecific T cell-derived factors.
α2-Heremans-Schmid Glycoprotein/ Fetuin-A Is Associated With Insulin Resistance and Fat Accumulation in the Liver in Humans
Authors: Norbert Stefan, Anita M. Hennige, Harald Staiger, Jürgen Machann, Fritz Schick, Stefan M. Kröber, Fausto Machicao, Andreas Fritsche, Hans-Ulrich Häring
Journal: Diabetes Care (2006)

The alpha(2)-Heremans-Schmid glycoprotein (AHSG; fetuin-A in animals) impairs insulin signaling in vitro and in rodents. Whether AHSG is associated with insulin resistance in humans is under investigation. In an animal model of diet-induced obesity that is commonly associated with hepatic steatosis, an increase in Ahsg mRNA expression was observed in the liver. Therefore, we hypothesized that the AHSG plasma protein, which is exclusively secreted by the liver in humans, may not only be associated with insulin resistance but also with fat accumulation in the liver.Data from 106 healthy Caucasians without type 2 diabetes were included in cross-sectional analyses. A subgroup of 47 individuals had data from a longitudinal study. Insulin sensitivity was measured by a euglycemic-hyperinsulinemic clamp, and liver fat was determined by (1)H magnetic resonance spectroscopy.AHSG plasma levels, adjusted for age, sex, and percentage of body fat, were higher in subjects with impaired glucose tolerance compared with subjects with normal glucose tolerance (P = 0.006). AHSG plasma levels were negatively associated with insulin sensitivity (r = -0.22, P = 0.03) in cross-sectional analyses. Moreover, they were positively associated with liver fat (r = 0.27, P = 0.01). In longitudinal analyses, under weight loss, a decrease in liver fat was accompanied by a decrease in AHSG plasma concentrations. Furthermore, high AHSG levels at baseline predicted less increase in insulin sensitivity (P = 0.02).We found that high AHSG plasma levels are associated with insulin resistance in humans. Moreover, AHSG plasma levels are elevated in subjects with fat accumulation in the liver. This is consistent with a potential role of AHSG as a link between fatty liver and insulin resistance.
Line tester analysis for seed yield and yield components in spring and winter type varieties of oil seed rape
Authors: V. Rameeh
Journal: Journal of Clinical Oncology (2011)

Line × tester analysis of two testers of spring type and six lines of winter type oil seed rape varieties were used to estimate combining ability and heterosis of yield components and seed yield. Significant mean squares of treatments for yield components and seed yield, indicating significant genetic variations among the genotypes including parents and their crosses. Parents vs crosses mean square which indicate average heterosis was significant for all the traits except pods per plant. Line × tester mean square was significant for all the traits except pods per plant. High narrow sense heritability estimate for 1000-seed weight indicating the prime importance of additive genetic effects for this trait. Significant positive general combining ability (GCA) effects of seed yield were observed for parents which had positive GCA effects of pods per plant. Most of the crosses with significant positive specific combining ability (SCA) effects for pods per plant had significant positive SCA effects of seed yield. Most of the crosses had significant positive over spring parent heterosis of seed yield, indicating winter type of oil seed rape varieties are suitable candidates for improving this trait using combination method.

	 

	Key words: Heterosis, narrow sense heritability, seed yield, oil seed rape.
Neoadjuvant Chemotherapy and Bevacizumab for HER2-Negative Breast Cancer
Authors: Gunter von Minckwitz, Holger Eidtmann, Mahdi Rezai, Peter A Fasching, Hans Tesch, Holm Eggemann, Iris Schrader, Kornelia Kittel, Claus Hanusch, Rolf Kreienberg, Christine Solbach, Bernd Gerber, Christian Jackisch, Georg Kunz, Jens-Uwe Blohmer, Jens Huober, Maik Hauschild, Tanja Fehm, Berit Maria Müller, Carsten Denkert, Sibylle Loibl, Valentina Nekljudova, Michael Untch
Journal: New England Journal of Medicine (2012)

Bevacizumab, a monoclonal antibody against vascular endothelial growth factor A, has shown clinical efficacy in patients with human epidermal growth factor receptor 2 (HER2)–negative metastatic breast cancer. We evaluated the efficacy, measured according to the rate of pathological complete response (absence of invasive and intraductal disease in the breast and the axillary lymph nodes), and the safety of adding bevacizumab to neoadjuvant chemotherapy in patients with early-stage breast cancer.