tbuckley/cabot-search huggingface dataset:
Remarks for the Banquet to Honor John Nemiah on His Retirement from the Chairmanship of Beth Israel’s Psychiatric Service
Authors: Fred H. Frankel
Journal: Psychotherapy and Psychosomatics (1986)

Other Types| February 17 2010 Remarks for the Banquet to Honor John Nemiah on His Retirement from the Chairmanship of Beth Israel's Psychiatric Service Subject Area: Psychiatry and Psychology Fred H. Frankel Fred H. Frankel Boston Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1986) 45 (1): 33–36. https://doi.org/10.1159/000287924 Article history Published Online: February 17 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Fred H. Frankel; Remarks for the Banquet to Honor John Nemiah on His Retirement from the Chairmanship of Beth Israel's Psychiatric Service. Psychother Psychosom 1 January 1986; 45 (1): 33–36. https://doi.org/10.1159/000287924 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1986Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Intravenous iron therapy for treatment of anaemia
Authors: L. A. McIntyre, A. Tinmouth, D. Fergusson
Journal: BMJ (2013)

Time for cautious optimism, not wide adoption

Compared with oral iron, intravenous iron represents an attractive intervention to treat both iron deficiency anaemia and anaemia of chronic disease.1 Earlier intravenous iron formulations were associated with anaphylaxis, though rare, but several intravenous iron formulations with better safety profiles are now available.2 In contrast to oral iron and its side effects that relate to gastrointestinal intolerance and reduced absorption from the small intestine, intravenous iron bypasses the gut. Consequently its absorption is not blocked by hepcidin, a peptide associated with anaemia of chronic disease.1 Intravenous iron may also improve mobilisation of iron stores, which is impaired with anaemia of chronic disease.3

In the linked systematic review and meta-analysis of randomised controlled trials, Litton and colleagues (doi:10.1136/bmj.f4822) assessed the effect of intravenous iron on changes in haemoglobin concentration, red blood cell transfusion requirements, and risk of infection.4 The review included 75 trials reporting over 10 000 patients from a variety of clinical settings (including renal failure, obstetrics, oncology, cardiology, and gastroenterology), 72 …
Serum allergen‐specific <scp>I</scp>g<scp>A</scp> is not associated with natural or induced tolerance to egg in children
Authors: M. Vazquez‐Ortiz, M. Pascal, M. Juan, L. Alsina, M. A. Martín‐Mateos, A. M. Plaza
Journal: Allergy (2013)

Abstract The role of specific I gA ( sIgA ) in oral immunotherapy ( OIT ) and natural tolerance to foods is poorly understood. We aimed to study serum sIgA in induced and natural tolerance to egg. Children aged 5–16 years diagnosed with I gE‐mediated egg allergy were recruited. After egg challenge, patients were classified as transient ( TEA ) or persistent ( PEA ) egg‐allergic. PEA children were further divided into oral immunotherapy ( PEA ‐ OIT ) or egg avoidance ( PEA ‐ EA ). Allergy/tolerance was reassessed 9–12 months later (T1) in PEA ‐ EA . Serum sIgA to ovalbumin and ovomucoid were determined at inclusion in all patients and repeated in PEA at T1. 21 TEA and 52 PEA children were recruited (28 PEA ‐OIT, 24 PEA ‐EA). Serum sIgA remained unchanged after OIT . TEA and PEA had similar serum sIgA . No specific trend on serum sIgA was observed in five PEA ‐ EA who developed natural tolerance over follow‐up. Thus, serum sIgA seems not to be associated with induced or natural egg tolerance.
The dynamic developmental theory of attention-deficit/hyperactivity disorder (ADHD): Present status and future perspectives
Authors: Espen Borgå Johansen, Terje Sagvolden, Heidi Aase, Vivienne Ann Russell
Journal: Behavioral and Brain Sciences (2005)

The dynamic developmental theory (DDT) has benefited from the insights of the commentators, particularly in terms of the implications for the proposed steepened delay gradients in attention-deficit/hyperactivity disorder (ADHD). The introduction of modified memory processes as a basis for the delay gradients improved the links to aspects of ADHD. However, it remains unclear whether the hyperactive-impulsive and inattentive subtypes are separate subgroups or may be explained as different outcomes of the same genetic factors and thus explicable by the same principles. The DDT suggests that altered reinforcement and extinction processes define an endophenotype in ADHD that can be related dimensionally to inattention, hyperactivity, and impulsivity. The relation between the suggested endophenotype, characterized by changes in basic learning mechanisms, and other endophenotypes characterized by delay aversion or response disinhibition, needs to be tested in future studies.
Immune gene signatures and tumor intrinsic markers delineate novel immunogenic subtypes of breast cancer
Authors: Lance D Miller, Jeff W Chou, Michael A Black, Cristin G Print, Eric Jimenez, Julia Chifman, Angela Alistar, Thomas C Putti, Xiaobo Zhou, Davide Bedognetti, Ashok Pullikuth, Eran Andrechek, Ena Wang, Francesco M Marincola
Journal: Journal for ImmunoTherapy of Cancer (2014)

Meeting abstracts The abundance and functional orientation of tumor-infiltrating effector cells has long been observed to predict for reduced incidence of clinical metastasis and cancer-specific death. Using bioinformatics to mine large breast tumor microarray datasets, we and others have
Acute lymphoblastic leukemia associated with RCSD1–ABL1 novel fusion gene has a distinct gene expression profile from BCR–ABL1 fusion
Authors: E De Braekeleer, N Douet-Guilbert, P Guardiola, D Rowe, S Mustjoki, A Zamecnikova, S Al Bahar, G Jaramillo, C Berthou, N Bown, K Porkka, C Ochoa, M De Braekeleer
Journal: Leukemia (2012)
Forever Young: A Cultural History of Longevity
Authors: Peter Crome
Journal: BMJ (2004)

Lucian Boia Reaktion Books, £16.95, pp 224 ISBN 1 86189 154 7www.reaktionbooks.co.uk Rating: ![Graphic][1]</img>![Graphic][2]</img> The Romanian historian Lucian Boia sees the pursuit of longevity, even to the eventual status of immortality, as a natural strategy for humankind. He cites the decline in religious belief and the afterlife, as well as the failure of secular “religions” such as Progress and Science, as key factors in the present interest in the subject. However, it seems a little odd to cite science's failure to provide solutions for humanity as one of the drivers of the quest for salvation through the prolongation of life—especially given medical science's record in providing many of the epidemiological explanations and treatments that have helped … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif
Tennis elbow myths
Authors: P. J. Mahaffey
Journal: BMJ (2011)

<h3>ABSTRACT</h3> Circadian (~24 h) rhythms influence nearly all aspects of physiology, including sleep/wake, metabolism, and hormone release. The suprachiasmatic nucleus (SCN) synchronizes these daily rhythms to the external light cycle, but the mechanisms by which this occurs is unclear. The neuropeptide vasoactive intestinal peptide (VIP) is the predominant contributor to synchrony within the SCN and is important for circadian light responses, but the role of VIP neurons themselves is unclear. Thus, we tested the hypothesis that rhythmic SCN VIP neurons mediate circadian light responses. Using <i>in vivo</i> fiber photometry recording of SCN VIP neurons we found daily rhythms in spontaneous calcium events that peaked during the subjective day and in light-evoked calcium events that exhibited the greatest response around subjective dusk. These rhythms were correlated with spontaneous and NMDA-evoked VIP release from SCN VIP neurons <i>in vitro</i>. Finally, <i>in vivo</i> hyperpolarization of VIP neurons attenuated light-induced shifts of daily rhythms in locomotion. We conclude that SCN VIP neurons are circadian and depolarize to light to modulate entrainment of daily rhythms in the SCN and behavior.
Susceptibility to Theiler's virus-induced demyelination. Mapping of the gene within the H-2D region.
Authors: M Rodriguez, J Leibowitz, C S David
Journal: The Journal of Experimental Medicine (1986)

Demyelination induced by Theiler's virus was examined in mouse strains with congeneic recombinant haplotypes. Light and electron microscopy of spinal cord sections from mice with s, q, v, p, and f H-2D alleles showed perivascular inflammation and primary demyelination. The presence of susceptible haplotypes in the K or I region did not correlate with pathologic abnormalities. The Qa, Tla, PgK, and UpG genes did not appear to be critical in determining susceptibility to disease. However, mutation in the H-2D genes altered the susceptibility to virus-induced demyelination. B10.D2dm1 mice, which have deletions in the 3' end of Dd and the 5' end of Ld, showed prominent demyelination and clinical deficits. In contrast, BALB/c-dm2, which have a deletion of the entire L gene, showed no pathologic changes. Central nervous system virus titers correlated with susceptibility to demyelination; both resistant and susceptible strains had a strong humoral immune response to the virus. The findings in the congeneic recombinant mice and in mice mutant in the H-2D region strongly suggest that at least one of the genes critical for determining virus-induced demyelination maps to the 3' end of the H-2D gene.
Self-assembled star-shaped chlorin-core poly(ɛ-caprolactone)–poly(ethylene glycol) diblock copolymer micelles for dual chemo-photodynamic therapies
Authors: Cheng-Liang Peng, Ming-Jium Shieh, Ming-Hsien Tsai, Cheng-Chung Chang, Ping-Shan Lai
Journal: Biomaterials (2008)
Developmental changes in calcium currents of rabbit ventricular cells.
Authors: T Osaka, R W Joyner
Journal: Circulation Research (1991)

We investigated the postnatal development of L-type Ca2+ current (ICa) in enzymatically isolated adult (AD) and newborn (NB) (1-3-day-old) rabbit ventricular cells using the whole-cell, patch-clamp method. ICa was recorded with Cs(+)-rich pipettes and a Na(+)- and K(+)-free bath solution at 36 degrees C to eliminate other currents. ICa density (obtained by normalizing ICa to the cell capacitance) was significantly higher in AD cells than in NB cells at potential levels between 0 and +50 mV with 1.8 mM Ca2+ as the charge carrier. There was no shift in the current-voltage relation between AD and NB cells. The maximum ICa density was 9.9 +/- 2.0 pA/pF at 14 +/- 5 mV in AD cells (n = 11) compared with 5.6 +/- 2.0 pA/pF at 13 +/- 5 mV in NB cells (n = 7) (mean +/- SD). Time to half inactivation (T 1/2) showed a nearly U-shaped relation to membrane potentials from -10 to +30 mV with the shortest T 1/2 at the potential giving the maximum ICa density in both groups. T 1/2 at 0 and +10 mV was slightly but significantly longer in NB cells (16.8 +/- 4.6 and 13.5 +/- 2.4 msec, respectively) than in AD cells (12.6 +/- 3.0 and 10.6 +/0 1.5 msec).(ABSTRACT TRUNCATED AT 250 WORDS)
Case of Hepatic Abscess, Suddenly Fatal
Authors: S. T. Chadwick
Journal: BMJ (1858)

usual ml-anner.The loose pieces of bone came away, and there was left a senmicircular opening on its left side, wbhicl measured three inches by twvo inches and a half.The line of fracture extended forwards and around the skull to the other side of the head.The middle fossa of the base of the skull was broklen into several pieces, and the roof of the orbit was
Can you catch rabies from your ferret? Probably not
Authors: Phil Gunby
Journal: JAMA (1981)

Ferrets are becoming increasingly popular pets in the United States, say veterinarians at the Centers for Disease Control (CDC), Atlanta, and physicians are getting more and more queries about possible rabies exposure from ferret bites. Attempting to ferret out more information about these little (35-cm-long) creatures, W. G. Winkler, DVM, is asking anyone with data about ferrets and rabies to telephone the CDC's viral diseases division (404/329-3727). In the meantime, he notes that, as a member of the Mustelidae family (which includes weasels, skunks, otters, and minks), "the ferret is assumed to be highly susceptible and capable of transmitting rabies if infected." Winkler explains that "according to one major producer, about 12,000 ferrets now are being sold each year in this country, half to the pet trade and half for research; ferrets are not used in the commercial fur industry." About a fivefold increase in ferret sales has occurred in
Mechanisms of alcohol-induced hepatic fibrosis: A summary of the Ron Thurman Symposium
Authors: Vishnudutt Purohit, David A. Brenner
Journal: Hepatology (2006)

This report is a summary of Ron Thurman Symposium on the Mechanisms of Alcohol-Induced Hepatic Fibrosis which was organized by The National Institutes of Health in Santa Barbara, California, June 25, 2005. The Symposium and this report highlight the unique aspects by which drinking alcoholic beverages may result in hepatic fibrosis. Acetaldehyde, the first metabolite of ethanol, can upregulate transcription of collagen I directly as well as indirectly by upregulating the synthesis of transforming growth factor-beta 1 (TGF-β1). Reactive oxygen species (ROS) generated in hepatocytes by alcohol metabolism can activate collagen production in hepatic stellate cells (HSCs) in a paracrine manner. Alcohol-induced hepatocyte apoptotic bodies can be phagocytosed by HSCs and Kupffer cells and result in increased expression of TGF-β1 and subsequent HSC activation. Kupffer cells may contribute to the activation of HSCs by releasing ROS and TGF- β1. Innate immunity may suppress hepatic fibrosis by killing activated HSCs and blocking TGF-β1 signaling. In patients infected with hepatitis C virus (HCV), alcohol may promote hepatic fibrosis by suppressing innate immunity. HCV core and non-structural proteins contribute to HCV-induced hepatic fibrosis. Alcohol and HCV together may promote hepatic fibrosis through increased oxidative stress and upregulation of fibrogenic cytokines. The inactive aldehyde dehydrogenase (ALDH2) and the super-active alcohol dehydrogenase (ADH2) alleles may promote hepatic fibrosis through increased accumulation of acetaldehyde in the liver. Hepatic fibrosis can be reversed by inducing selective apoptosis or necrosis of activated HSCs, or by reverse trans-differentiation of activated HSCs into the quiescent phenotype. (HEPATOLOGY 2006;43:872–878.)
Principles and Practice of Dermatology
Authors: Philip D. Shenefelt
Journal: JAMA (1997)

The second edition of this single-volume textbook of dermatology (85 chapters, 80 contributors, 1003 pages of text) continues the format established in the first edition (87 chapters, 75 contributors, 976 pages of text) of high-quality, all-color clinical photographs surrounded by succinct text and summary tables. All chapters have been revised, with expansion of those on the structure and function of skin and on AIDS, and a chapter on cosmetic dermatology has been added. As in the first edition, the primary factor that sets this second edition apart from most of the other textbooks of dermatology is its superb clinical photographs. A few are underexposed, overexposed, slightly out of focus, or lacking in sufficient contrast, but the great majority illustrate the typical lesions of the specific diseases with great clarity and intensity. The text is again well edited, with the styles of the 80 contributors (61 returning) blended for uniformity and
New EU trials database is criticised for lack of openness
Authors: Jane Burgermeister
Journal: BMJ (2004)

Experts have warned that the European Union's decision to restrict access to a new clinical trials database to government regulatory authorities will make it more difficult to decide whether commonly used treatments are effective.

Dr Gerd Antes, head of the German Cochrane centre and spokesman for the German Network for Evidence Based Medicine, said that the information on the new European clinical trials database (Eudract) should be made available to the general public as well as to medical researchers.

“Making clinical trial registers available to the public is a scientific, economic, and ethical duty,” he told the German weekly newspaper Die Zeit .

Under the European clinical trials directive, …
The Parkes Museum of Hygiene
Authors: G. V. Poore, A. Carpenter, W. H. Corfield, F. S. B. F. de Chaumont, T. Crawford, R. T. Thorne, L. C. Parkes, M. B. Hill, J. C. Steele, D. Williams, E. W. Wallis
Journal: BMJ (1887)
THERAPEUTICS XVI.
Authors: Heather Ashton, C. J. tevensonS, E. Frenk
Journal: British Journal of Dermatology (1971)

Journal Article THERAPEUTICS XVI: Retinoic Acid Get access Heather Ashton, Heather Ashton Pharmacology Department University of Newcastle upon Tyne Search for other works by this author on: Oxford Academic Google Scholar C. J. TevensonS, C. J. TevensonS Royal Victoria Infirmary Newcastle upon Tyne Search for other works by this author on: Oxford Academic Google Scholar E. Frenk E. Frenk Clinique Dermatologique Universitaire Lausanne, Switzerland Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 85, Issue 5, 1 November 1971, Pages 500–503, https://doi.org/10.1111/j.1365-2133.1971.tb14072.x Published: 01 November 1971
Role of osteopontin in amplification and perpetuation of rheumatoid synovitis
Authors: Guangwu Xu, Hong Nie, Ningli Li, Wenxin Zheng, Dongqing Zhang, Guozhang Feng, Liqing Ni, Rong Xu, Jian Hong, Jingwu Z. Zhang
Journal: Journal of Clinical Investigation (2005)

Osteopontin (OPN) is an extracellular matrix protein of pleiotropic properties and has been recently recognized as a potential inflammatory cytokine. In this study, we demonstrate, for the first time to our knowledge, that overexpression of OPN in synovial T cells is associated with local inflammatory milieu and that OPN acts as an important mediator in amplification and perpetuation of rheumatoid synovitis. The study revealed that mRNA expression of OPN was highly elevated in CD4+ synovial T cells derived from patients with RA, which correlated with increased OPN concentrations in synovial fluid (SF). The pattern of OPN overexpression was confined to rheumatoid synovium and correlated with coexpression of selected OPN receptors in synovial T cells, including integrins αv and β1 and CD44. RA-derived SF stimulated the expression of OPN in T cells, which was attributable to IL-10 present in SF and abrogated by anti–IL-10 antibody. Among the more than 300 autoimmune and inflammatory response genes examined, OPN selectively induced the expression of proinflammatory cytokines and chemokines known to promote migration and recruitment of inflammatory cells. Furthermore, it was evident that OPN activated transcription factor NF-κB in mononuclear cells. The study has important implications for understanding the role of OPN in rheumatoid synovitis and other inflammatory conditions.
Abstract LB-35: Living biobank of cancer organoids for drug development and screening
Authors: Robert G.J. Vries, Hans Clevers
Journal: Cancer Research (2014)

Abstract Future cancer therapy will rely on treatment with drugs that are specific for individual tumours and patients. However, predicting clinical responses from genomic data remains highly challenging. Recently, systematic screens utilizing large panels of tumor cell lines have been used to correlate drug sensitivity with tumor genotype to identify predictive genomic markers of drug response. However, tumour cell lines have several drawbacks including being of limited genetic diversity; pre-clinical models that are more representative of the ‘natural’ mutational diversity of cancer are urgently required. The Clevers lab recently developed methods for long-term culture of human primary tissues and cancers (‘organoids’). By establishing a large collection of tumour-specific organoids, the genetic spectrum of tumours can be captured as a pre-clinical model. This will allow stratification of tumours based on their genomic footprint and drug sensitivity, and may reveal correlations between drug sensitivity and this footprint. We have now established the organoid technology and the first biobank of Colon, Pancreas, and Lung primary carcinomas and metastasis. Importantly, whole genome sequencing of the initial tumour material and long term cultures demonstrate that, similar to healthy organoids, also tumour organoids are stable. The first screens with sets of drugs that are clinically available shows that the organoids respond as would be predicted by their sequence analysis, such as KRAS mutant organoids not responding to the EGFR inhibitor Cetuximab. We do however find patient specific differences which points to a promising role for organoids in drug development, patient stratification and possibly diagnosis. Finally, genetic analysis has indicated that we are efficiently generating organoids of the full range of genetic alterations previously identified in patients for these tumour types, including specific genotypes that are poorly or not represented in any other in vitro model at the moment. Citation Format: Robert G.J. Vries, Hans Clevers. Living biobank of cancer organoids for drug development and screening. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr LB-35. doi:10.1158/1538-7445.AM2014-LB-35
The Black Veil
Authors: J. A. S. Beard, C. Chubb
Journal: BMJ (2011)

In addition to his many novels, Charles Dickens also compiled several short pieces that were published largely in newspapers and magazines. His first collection of these, Sketches by “Boz” was released in 1836 when he was just 24 years old. The publication gave vivid descriptions of both fictional and non-fictional London life. Of the former, “The Black Veil” stands out as a chillingly macabre tale.

Dickens introduces a young metropolitan doctor struggling to find work in the crowded medical marketplace of the early 19th century. He awaits the custom of his first patient one cold winter’s evening …