tbuckley/cabot-search huggingface dataset:
Response to Comment on Tsuda et al. Poor Glycemic Control Is a Major Factor in the Overestimation of Glomerular Filtration Rate in Diabetic Patients. Diabetes Care 2014;37:596–603
Authors: Akihiro Tsuda, Eiji Ishimura, Masaaki Inaba
Journal: Diabetes Care (2014)

Thank you for attention to our recent article and the comments from Drs. Delanaye and Scheen (1). First, as described in the limitation section of our article (2), our study was performed using a relatively small number of Japanese patients ( n = 80) from a single hospital at Osaka City University Hospital, and further large-scale studies with a greater number of patients in several hospitals will be necessary to confirm the clinical validity of estimated glomerular filtration rate (eGFR) correction by hemoglobin A1c. However, we consider that performing this laborious and relatively complicated study of inulin clearance (Cin) using a constant …
Autoantibodies against the High-Affinity IgE Receptor as a Cause of Histamine Release in Chronic Urticaria
Authors: Michihiro Hide, David M. Francis, Clive Grattan, John Hakimi, Jarema P. Kochan, Malcolm W. Greaves
Journal: New England Journal of Medicine (1993)

Most urticarias are induced by vasoactive mediators such as histamine released from mast cells. Although mast cells are activated by allergens through cross-linking of cell-surface-bound IgE, this mechanism does not appear to explain most cases of chronic urticaria, which, when allergic, infectious, drug-induced, or physical causes cannot be identified, are classified as idiopathic.
Peptic ulcer in rheumatoid arthritis.
Authors: D Farah, R D Sturrock, R I Russell
Journal: Annals of the Rheumatic Diseases (1988)

In a study of patients attending a rheumatology clinic 230 unselected patients, 185 with rheumatoid arthritis (RA) and 45 with other rheumatic disorders (non-RA), were examined by endoscopy and a detailed history of symptoms referable to the gastrointestinal tract was taken. A peptic ulcer was found in 67 (36%) of the patients and in 13 (29%) of the non-RA group. Gastric ulceration was more common in the group with RA (32 patients (17%) compared with three patients (7%) in the non-RA group); 17/32 (53%) patients with RA and gastric ulcer were asymptomatic. In the group with RA, of those with gastric ulcer 20/32 (63%) were smokers, compared with only 40/118 (34%) of the non-ulcer group. There was no difference in the duration of rheumatic disease or non-steroidal anti-inflammatory drug (NSAID) treatment between the ulcer and non-ulcer groups. Treatment with H2 receptor antagonist and maintenance of NSAID treatment resulted in healing in 26 out of 29 (90%) patients with gastric ulcer and 23 out of 27 (85%) patients with duodenal ulcer.
Chiropractic spinal manipulation for back pain * Commentary
Authors: E Ernst
Journal: British Journal of Sports Medicine (2003)

The effectiveness of chiropractic spinal manipulation for back pain is uncertain

Sports medicine clinicians with varied training include joint mobilisation and manipulation among their therapeutic skills. Examples include chiropractors, physiotherapists, and osteopaths, not to mention the doctors and massage therapists who treat various joint pathologies. Although athletes rarely have osteoporosis, the broad field of sports medicine includes the use of exercise therapies and treatment of the musculoskeletal system in people of all ages. Therefore this leader focuses on the role of chiropractic joint manipulation.

Back pain sufferers from more than 60 countries consult chiropractors.1 A booklet by the British Chiropractic Association boldly states that “95% of back pain is mechanical in origin, and can be treated by a chiropractor in a primary care setting”.2 Yet there are many who doubt such promotional statements. A recent, perhaps more sober, assessment of the data reads differently: “43 randomised trials of spinal manipulation for treatment of acute, subacute and chronic low back pain have been published. 30 favoured manipulation over the comparison treatment in at least a subgroup of patients and the other 13 found no significant differences”.3 However, these trials used mostly non-chiropractic spinal manipulation. The only systematic review of exclusively chiropractic spinal manipulation concluded that “the available RCTs provided no convincing evidence of the effectiveness of chiropractic for acute or chronic low back pain”.4 Since the publication of this article, the emerging trial data have not tended to be encouraging. The effectiveness of chiropractic spinal manipulation for back pain is …
Effects of Nonselective Cyclooxygenase Inhibition with Low-Dose Ibuprofen on Tumor Growth, Angiogenesis, Metastasis, and Survival in a Mouse Model of Colorectal Cancer
Authors: Min Yao, Wei Zhou, Simren Sangha, Andrew Albert, Albert J. Chang, Thomas C. Liu, M. Michael Wolfe
Journal: Clinical Cancer Research (2005)

Abstract Purpose: To determine whether the nonselective and relatively inexpensive nonsteroidal anti-inflammatory drug ibuprofen would be effective in inhibiting colorectal cancer and might improve mortality in a mouse model. Experimental Design: The effects of ibuprofen on tumor growth inhibition and animal survival have been examined in both mouse and human colorectal cancer tumor models. Angiogenesis was measured by in vitro endothelial cell tube formation and immunohistochemistry. Results: Ibuprofen significantly inhibited cell proliferation in mouse (MC-26) and human (HT-29) colorectal cancer cell lines. In vitro angiogenesis assays also indicated that ibuprofen decreased both cell proliferation and tube formation. The administration of chow containing 1,360 ppm ibuprofen, which achieved an average plasma concentration of ibuprofen lower than the peak level achieved in humans at therapeutic doses, inhibited tumor growth by 40% to 82%. Fewer liver metastases were found in the ibuprofen group compared with the control group. In combination therapy with the standard antineoplastic agents, 5-fluorouracil, or irinotecan (CPT-11), tumor volumes in the groups with ibuprofen ± CPT-11 or 5-fluorouracil were smaller than in the control group. Ibuprofen was similar to the cyclooxygenase-2 selective inhibitor rofecoxib in its ability to suppress tumor growth and improve overall survival. Conclusions: Ibuprofen, in part by modulating tumor angiogenesis, decreases both tumor growth and metastatic potential in mice. The ibuprofen doses were in the low range of therapeutic human plasma concentrations. Ibuprofen potentiates the antitumor properties of CPT-11 and improves survival of mice without increasing gastrointestinal toxicity.
Cigarette smoking and alcohol consumption as determinants of survival in non-Hodgkin's lymphoma: a population-based study
Authors: T. Battaglioli, G. Gorini, A. Seniori Costantini, P. Crosignani, L. Miligi, O. Nanni, E. Stagnaro, R. Tumino, P. Vineis
Journal: Annals of Oncology (2006)
Effect of the RET Inhibitor Vandetanib in a Patient With RET Fusion–Positive Metastatic Non–Small-Cell Lung Cancer
Authors: Gerald S. Falchook, Nelson G. Ordóñez, Christel C. Bastida, Philip J. Stephens, Vincent A. Miller, Lindsay Gaido, Tiffiny Jackson, Daniel D. Karp
Journal: Journal of Clinical Oncology (2014)
Prevalence and distribution of sensitization to foods in the European Community Respiratory Health Survey: a EuroPrevall analysis
Authors: P. Burney, C. Summers, S. Chinn, R. Hooper, R. Van Ree, J. Lidholm
Journal: Allergy (2010)

To cite this article: Burney P, Summers C, Chinn S, Hooper R, van Ree R, Lidholm J. Prevalence and distribution of sensitization to foods in the European Community Respiratory Health Survey: a EuroPrevall analysis. Allergy 2010; 65 : 1182–1188. Abstract Background: Reports of adverse reactions to foods are increasing, but there is limited information on the comparative prevalence of sensitization to food allergens using standardized methods. Methods: Sera from the ‘random sample’ of young adults seen during the second phase of the European Community Respiratory Health Survey were analysed for IgE against 24 foods using ImmunoCAP. Sera were tested on five food mixes, and subsequently on individual foods in each positive mix. Results: Sera from 4522 individuals living in 13 countries were tested for at least one food allergen mix. Prevalence of sensitization to any of the 24 food allergens ranged from 24.6% in Portland (USA) to 7.7% in Reykjavik (Iceland). With few exceptions, the relative prevalence of sensitization to different foods was similar in all countries. Sensitization rates to egg, fish and milk were each less than 1%, and the most common sensitizations are not represented in current commercial mixes. The prevalence of sensitization to foods was not related to that of sensitization to aeroallergens but was related to the geometric mean total IgE for the country. Conclusions: Sensitization to foods is common but highly variable. The relative prevalence of sensitization to different foods is more consistent than would be expected by chance, suggesting that quantity of consumption of specific foods does not determine prevalence. The aetiology of food sensitization is only partly similar to that for aeroallergens but is related to local levels of total IgE. This may provide an important clue to the origins of food sensitization.
Effect of Maternal Use of Antiretroviral Agents on Serum Insulin Levels of the Newborn Infant
Authors: Patrícia El Beitune, Geraldo Duarte, Milton C. Foss, Renan M. Montenegro, Silvana M. Quintana, Ernesto A. Figueiró-Filho, Antonio A. Nogueira
Journal: Diabetes Care (2005)

OBJECTIVE—The aim of this study was to investigate the effect of antiretroviral drugs on neonatal serum insulin levels. RESEARCH DESIGN AND METHODS—A prospective study was conducted on 57 pregnant women divided into three groups: the zidovudine (ZDV) group, HIV-infected women taking ZDV (n = 20); the triple treatment group, HIV-infected women taking triple antiretroviral agents ZDV + lamivudine + nelfinavir (n = 25); and the control group, pregnant women considered normal from a clinical and laboratory standpoint (n = 12). Blood was collected from the umbilical cord of newborn infants upon delivery for measurement of insulin level. The insulin measurements were performed in duplicate by radioimmunoassay. RESULTS—Demographic and anthropometric data were homogeneous, and pregnant women with a personal and family history of diabetes were excluded. There was no difference between groups regarding glycemia in the newborn. Median newborn insulin doses were 2.9, 4.8, and 6.5 μU/ml for the triple treatment, ZDV, and control groups, respectively (P &amp;lt; 0.05). CONCLUSIONS—Use of triple therapy during pregnancy induced a significant decrease in serum levels of neonatal insulin compared with the control group. Active surveillance of short- and long-term adverse events is imperative to issue a definitive statement regarding the impact that use of protease inhibitors during pregnancy will have on infant metabolism.
Selective Publication of Antidepressant Trials and Its Influence on Apparent Efficacy
Authors: Erick H. Turner, Annette M. Matthews, Eftihia Linardatos, Robert A. Tell, Robert Rosenthal
Journal: New England Journal of Medicine (2008)

Evidence-based medicine is valuable to the extent that the evidence base is complete and unbiased. Selective publication of clinical trials--and the outcomes within those trials--can lead to unrealistic estimates of drug effectiveness and alter the apparent risk-benefit ratio.We obtained reviews from the Food and Drug Administration (FDA) for studies of 12 antidepressant agents involving 12,564 patients. We conducted a systematic literature search to identify matching publications. For trials that were reported in the literature, we compared the published outcomes with the FDA outcomes. We also compared the effect size derived from the published reports with the effect size derived from the entire FDA data set.Among 74 FDA-registered studies, 31%, accounting for 3449 study participants, were not published. Whether and how the studies were published were associated with the study outcome. A total of 37 studies viewed by the FDA as having positive results were published; 1 study viewed as positive was not published. Studies viewed by the FDA as having negative or questionable results were, with 3 exceptions, either not published (22 studies) or published in a way that, in our opinion, conveyed a positive outcome (11 studies). According to the published literature, it appeared that 94% of the trials conducted were positive. By contrast, the FDA analysis showed that 51% were positive. Separate meta-analyses of the FDA and journal data sets showed that the increase in effect size ranged from 11 to 69% for individual drugs and was 32% overall.We cannot determine whether the bias observed resulted from a failure to submit manuscripts on the part of authors and sponsors, from decisions by journal editors and reviewers not to publish, or both. Selective reporting of clinical trial results may have adverse consequences for researchers, study participants, health care professionals, and patients.
A study of left ventricular function in coronary patients before and after physical training.
Authors: B Letac, A Cribier, J F Desplanches
Journal: Circulation (1977)

Fifteen subjects recovering from a myocardial infarction or suffering from angina were given a maximum effort test on a bicycle ergometer and hemodynamic and angiographic investigations before and after a period of physical training. The training program consisted of three sessions of 60 to 75 min each week for two months. Maximum effort tests showed that physical capacity had increased by 17% (P less than 0.02) and that for the same amount of effort the heart rate had decreased by 13% and the blood pressure by 7% (P less than 0.01). Hemodynamic and angiographic investigations showed no significant changes after training in the left ventricular end-diastolic pressure, ventricular volume, ejection fraction, VCF, percentage of shortening and segmental contractility, in the total group, in those patients whose contractility was considerably impaired, or in those who had large dyskinetic areas or widespread akinesia. It is concluded that training had no direct influence on the myocardium, either beneficial or detrimental.
Intermittent Target Inhibition With Dasatinib 100 mg Once Daily Preserves Efficacy and Improves Tolerability in Imatinib-Resistant and -Intolerant Chronic-Phase Chronic Myeloid Leukemia
Authors: Neil P. Shah, Hagop M. Kantarjian, Dong-Wook Kim, Delphine Réa, Pedro E. Dorlhiac-Llacer, Jorge H. Milone, Jorge Vela-Ojeda, Richard T. Silver, H. Jean Khoury, Aude Charbonnier, Nina Khoroshko, Ronald L. Paquette, Michael Deininger, Robert H. Collins, Irma Otero, Timothy Hughes, Eric Bleickardt, Lewis Strauss, Stephen Francis, Andreas Hochhaus
Journal: Journal of Clinical Oncology (2008)

Dasatinib is a BCR-ABL inhibitor, 325-fold more potent than imatinib against unmutated BCR-ABL in vitro. Phase II studies have demonstrated efficacy and safety with dasatinib 70 mg twice daily in chronic-phase (CP) chronic myelogenous leukemia (CML) after imatinib treatment failure. In phase I, responses occurred with once-daily administration despite only intermittent BCR-ABL inhibition. Once-daily treatment resulted in less toxicity, suggesting that toxicity results from continuous inhibition of unintended targets. Here, a dose- and schedule-optimization study is reported.In this open-label phase III trial, 670 patients with imatinib-resistant or -intolerant CP-CML were randomly assigned 1:1:1:1 between four dasatinib treatment groups: 100 mg once daily, 50 mg twice daily, 140 mg once daily, or 70 mg twice daily.With minimum follow-up of 6 months (median treatment duration, 8 months; range, < 1 to 15 months), marked and comparable hematologic (complete, 86% to 92%) and cytogenetic (major, 54% to 59%; complete, 41% to 45%) response rates were observed across the four groups. Time to and duration of cytogenetic response were similar, as was progression-free survival (8% to 11% of patients experienced disease progression or died). Compared with the approved 70-mg twice-daily regimen, dasatinib 100 mg once daily resulted in significantly lower rates of pleural effusion (all grades, 7% v 16%; P = .024) and grade 3 to 4 thrombocytopenia (22% v 37%; P = .004), and fewer patients required dose interruption (51% v 68%), reduction (30% v 55%), or discontinuation (16% v 23%).Dasatinib 100 mg once daily retains the efficacy of 70 mg twice daily with less toxicity. Intermittent target inhibition with tyrosine kinase inhibitors may preserve efficacy and reduce adverse events.
Iterative orthology prediction uncovers new mitochondrial proteins and identifies C12orf62 as the human ortholog of COX14, a protein involved in the assembly of cytochrome c oxidase
Authors: Radek Szklarczyk, Bas FJ Wanschers, Thomas D Cuypers, John J Esseling, Moniek Riemersma, Mariël AM van den Brand, Jolein Gloerich, Edwin Lasonder, Lambert P van den Heuvel, Leo G Nijtmans, Martijn A Huynen
Journal: Genome biology (2012)

Orthology is a central tenet of comparative genomics and ortholog identification is instrumental to protein function prediction. Major advances have been made to determine orthology relations among a set of homologous proteins. However, they depend on the comparison of individual sequences and do not take into account divergent orthologs. We have developed an iterative orthology prediction method, Ortho-Profile, that uses reciprocal best hits at the level of sequence profiles to infer orthology. It increases ortholog detection by 20% compared to sequence-to-sequence comparisons. Ortho-Profile predicts 598 human orthologs of mitochondrial proteins from Saccharomyces cerevisiae and Schizosaccharomyces pombe with 94% accuracy. Of these, 181 were not known to localize to mitochondria in mammals. Among the predictions of the Ortho-Profile method are 11 human cytochrome c oxidase (COX) assembly proteins that are implicated in mitochondrial function and disease. Their co-expression patterns, experimentally verified subcellular localization, and co-purification with human COX-associated proteins support these predictions. For the human gene C12orf62, the ortholog of S. cerevisiae COX14, we specifically confirm its role in negative regulation of the translation of cytochrome c oxidase. Divergent homologs can often only be detected by comparing sequence profiles and profile-based hidden Markov models. The Ortho-Profile method takes advantage of these techniques in the quest for orthologs.
C-Care: Impact of Labeling in Food Induced Anaphylaxis in Children Treated at the Montreal Children's Hospital
Authors: Sarah De Schryver, Ann Elaine Clarke, Sebastien La Vieille, Reza Alizadehfar, Alizee Dery, Christopher Mill, Lawrence Joseph, Harley Eisman, Judy Morris, Moshe Ben-Shoshan
Journal: Journal of Allergy and Clinical Immunology (2015)
Thermo-reactive clips do not prevent sternal wound infection in obese patients after cardiac surgery
Authors: Clare Burdett, Simon Kendall, Joel Dunning, Andrew Owens, Andrew Goodwin, Steve Hunter, Jonathan Ferguson, Tracey Smailes, Cheng-Hon Yap, Enoch Akowuah
Journal: International Journal of Surgery (2013)

s / International Journal of Surgery 11 (2013) 589e685 613 ABSTRACTS Conclusion: The results were accessible, useable and reliable, shown by the LIDA tool. The information required a high level of education, shown by the Gunning-Fog Index and Flesch Readability Score. The best three websites for patient self-education about mitral valve replacement are: http://www.drugs.com/cg/mitral-valve-replacementinpatient-care.html, http://www.nhs.uk/conditions/Aorticvalvereplace ment/Pages/Whatisitpage.aspx, http://www.bhf.org.uk/heart-health/ treatments/valve-heart-surgery.aspx 0683: STARTING & EVALUATING A ROBOT-ASSISTED VATS PROGRAMME: PILOT PHASE Sandra Gelvez-Zapata, Maral Rouhani, Rachel Kuo, Priya Sastry, Aman S. Coonar. Papaworth Hospital, Cambridge, UK. Aim: The Freehand TM robot scope holder has been recently released. We sought to assess the feasibility of implementing and using this robotassisted telescope holder in VATS. This is first use in thoracic surgery. Methods: Following dry-lab training of the consultant and theatre team by an experienced trainer we introduced the system into the operating room. Non-lobectomy patients were considered for robot-assisted VATS (RVATS). 27 consecutive VATS patients were selected. 22 procedures were completed by R-VATS. The procedures were 9 wedge resections, 7 pneumothorax, 2 lung volume resections (LVRS), 3 empyema and 1 pleurectomy for mesothelioma. Results: Surgical time (including on table-robot positioning): 50 115 min (mean 82). Total operating room time (including robot set-up/take down): 65 140min (mean 111). R-VATcases by consultant with assistant available but hands-off: 21/22. R-VAT cases by trainee with consultant scrubbed:1/ 22 Conclusions: Dry-lab preparation allowed robot position to be optimized. Implementation was rapid and safe. Consideration of robot placement and port position is critical. The robot gave a stable, non-wandering view. Assistants observed the procedure, but were not required to participate. Since these procedures can be conducted by a single operator there are manpower implications. Operative and theatre times are acceptable. 0801: THERMO-REACTIVE CLIPS DO NOT PREVENT STERNAL WOUND INFECTION IN OBESE PATIENTS AFTER CARDIAC SURGERY Clare Burdett, Simon Kendall, Joel Dunning, Andrew Owens, Andrew Goodwin, Steve Hunter, Jonathan Ferguson, Tracey Smailes, Cheng-Hon Yap, Enoch Akowuah. James Cook University Hospital,
IgE class-restricted tolerance induced by neonatal administration of soluble or cell-bound IgE. Cellular mechanisms.
Authors: S S Chen, F T Liu, D H Katz
Journal: The Journal of Experimental Medicine (1984)

Certain aspects of the phenomenon of IgE class-restricted tolerance induced in mice by neonatal treatment with monoclonal IgE, either in soluble form or coupled to syngeneic spleen cells, were examined. The present studies document that this tolerance results from exposure to IgE molecules, irrespective of their antigen specificity, and the resulting effects are polyclonal in nature since IgE responses directed against antigenic determinants unrelated to the tolerance-inducing IgE molecules are affected. Moreover, such findings indicate that the molecular subregion(s) responsible for inducing IgE class-restricted tolerance resides in the epsilon heavy chain constant region domain(s) of IgE. When soluble IgE is employed, tolerance induction results from neonatal treatment with doses as low as 2.5 micrograms per injection per mouse; cell-bound IgE is considerably more potent, in terms of total dose required, since tolerance results from treatment with as few as 1 X 10(6) cells per injection (per mouse), equivalent to an absolute quantity of 0.2 ng of IgE per injection. This long-term class-specific tolerance appears to be a unique feature of the IgE antibody system, since treatment of mice with monoclonal antibodies of the IgA, IgG1, or IgG2b isotypes, either in soluble or cell-bound form, does not perturb antibody responses of their corresponding isotypes or in the IgE class. By analyzing the lymphoid cells of IgE-tolerant mice after they reached adulthood, the following observations were made: (a) lymphoid cells from such tolerant mice fail to develop FcR epsilon + cells upon in vitro stimulation with IgE, as is characteristically observed with lymphoid cells from nontolerant mice; and (b) mice rendered tolerant by neonatal treatment with soluble IgE possess IgE class-restricted suppressor T cells, demonstrable in adoptive transfer experiments, whereas no such suppressor cells are evident in mice in which cell-bound IgE was used for neonatal treatment. The latter observations could mean that two different mechanisms underlie the IgE class-restricted tolerance, or both mechanisms operate coordinately to varying degrees depending upon which regimen is used for tolerance induction, as discussed herein.