Pentazocine—A Nonaddicting Analgesic
Authors: J. WELDON BELLVILLE
Journal: Annals of Internal Medicine (1967)

Editorial Notes1 November 1967Pentazocine—A Nonaddicting AnalgesicJ. WELDON BELLVILLE, M.D.J. WELDON BELLVILLE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-5-1114 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFor more than 75 years researchers have been trying to find a potent, nonaddicting analgesic. The U. S. Food and Drug Administration recently approved one of the first such compounds for clinical use, pentazocine (Talwin⌖, WIN 20,228). This may herald a new era in analgesia if similar compounds can be found to complement pentazocine and give us an effective group of nonaddicting agents to meet the full spectrum of patient needs.About a decade ago May and Murphy (1) described the first synthesis of benzomorphans. Certain quantitative differences were subsequently observed between the effects of these compounds and morphine, which...References1. MAYMURPHY ELJG: Structures related to morphine. III. Synthesis of an analog of N-methylmorphinan. J. Org. Chem. 20: 257, 1955. CrossrefGoogle Scholar2. LASAGNABEECHER LHK: The analgesic effectiveness of nalorphine and nalorphine-morphine combinations in man. J. Pharmacol. Exp. Ther. 112: 356, 1954. MedlineGoogle Scholar3. FRASERROSENBERG HFDE: Studies on the human addiction liability of 2′-hydroxy-5-9-dimethyl-2-(3,3-dimethylallyl)-6,7-benzomorphan (WIN 20,228): a weak narcotic antagonist. J. Pharmacol. Exp. Ther. 143: 149, 1964. MedlineGoogle Scholar4. EDDY NB: The search for a potent non-addicting analgetic, in New Concepts in Pain and Its Clinical Management, edited by WAY, E. L. F. A. Davis Co., Philadelphia, 1967, pp. 65-84. Google Scholar5. BELLVILLEGREEN JWJ: The respiratory and subjective effects of pentazocine. Clin. Pharmacol. Ther. 6: 152, 1965. CrossrefMedlineGoogle Scholar6. FORRESTBEERBELLVILLEBRIDGESCILIBERTIMANHEIMERMILLERPADDOCK WHEGJWBEBWER: Report of the Veterans Administration cooperative analgesic study, in Bulletin, Problems of Drug Dependence. National Academy of Sciences-National Research Council, Division of Medical Sciences, 1966, appendix 21, pp. 4673-4691. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: J. WELDON BELLVILLE, M.D.Affiliations: Department of Anesthesia Stanford University School of Medicine Palo Alto, Calif. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPentazocine use among people who inject drugs in IndiaSpontaneous Live Birth with a Maternal History of Intravenous Use of Pentazocine and Tripelennamine (T's and Blues)Pentazocine/tripelennamine (T's and Blues) abuse: A five year survey of St. Louis, MissouriSkin manifestations of pentazocine abuseCurrent Trends in the Abuse of Pentazocine and Tripelennamine: The Metropolitan St. Louis ExperienceA Note on the Misuse of Pentazocine and DextropropoxyphenePENTAZOCINE IN HOSPITALIZED PATIENTS 1 November 1967Volume 67, Issue 5Page: 1114-1115KeywordsAnalgesiaAnalgesicsFood and Drug AdministrationMorphine ePublished: 1 December 2008 Issue Published: 1 November 1967 PDF downloadLoading ...