tbuckley/cabot-search huggingface dataset:
PPI use in the first trimester was not associated with increased risk for birth defects; PPI use 1 to 4 weeks before conception was
Authors: Rory Windrim
Journal: Annals of Internal Medicine (2011)

ACP Journal Club21 June 2011PPI use in the first trimester was not associated with increased risk for birth defects; PPI use 1 to 4 weeks before conception wasRory Windrim, MDRory Windrim, MDMaternal Fetal Medicine, University of Toronto, Toronto, Ontario, Canada (R.W.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-154-12-201106210-02011 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationPasternak B, Hviid A. Use of proton-pump inhibitors in early pregnancy and the risk of birth defects. N Engl J Med. 2010;363:2114-23. https://pubmed.ncbi.nlm.nih.gov/21105793Clinical Impact RatingsGIM/FP/GP: Gastroenterology: Reference1 Richter JE. Gastroesophageal reflux disease during pregnancy. Gastroenterol Clin North Am. 2003;32:235-61. [PMID: 12635418] Google Scholar Author, Article, and Disclosure InformationAuthors: Rory Windrim, MDAffiliations: Maternal Fetal Medicine, University of Toronto, Toronto, Ontario, Canada (R.W.)This article was published at Annals.org on 7 June 2011. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNowcasting GDP and its Components in a Data-Rich Environment: The Merits of the Indirect Approach 21 June 2011Volume 154, Issue 12Page: JC6-11KeywordsBirthCohort studiesCongenital disordersGastroesophageal reflux diseaseInfantsPregnancyPrevalence odds ratioProton pump inhibitorsResearch fundingSelective serotonin reuptake inhibitors ePublished: 21 June 2011 Issue Published: 21 June 2011 Copyright & PermissionsCopyright © 2011 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Abstract 2345: Identification of epithelial stromal interaction 1 as a novel target of KLF8
Authors: Tianshu Li, Heng Lu, Xianhui Wang, Lin Yu, Jihe Zhao
Journal: Cancer Research (2011)

Abstract Epithelial stromal interaction 1 (EPSTI1) is a recently identified novel gene with two splicing variants that is highly upregulated in breast cancer cells when co-cultured with the stromal fibroblasts and in invasive breast carcinomas as compared with normal breast biopsies. The regulation and function of EPSTI1 are largely unknown. Interestingly, our microarray studies showed that EPSTI1 is one of the most upregulated genes in MCF-10A cells expressing ectopic Kruppel-like factor 8 (KLF8), a transcriptional factor is highly over-expressed in breast cancer and critical for cell cycle progression, oncogenic transformation, epithelial to mesenchymal transition (EMT) and metastatic progression of breast cancer. Real time qRT-PCR and western blotting demonstrated that EPSTI1 mRNA and protein levels are upregulated in a panel of invasive breast cancer cell lines that are known for aberrant overexpression of KLF8 as compared to noninvasive cell lines. Promoter reporter analysis indicated that KLF8 may activate EPSTI1 gene promoter. These results identified EPSTI1 as a novel target of KLF8 and suggest that EPSTI1 may play an important role for KLF8 signaling in the regulation of breast cancer invasion and metastasis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2345. doi:10.1158/1538-7445.AM2011-2345
Superiority of Radiobinding Assay Over ELISA for Detection of IAAs in Newly Diagnosed Type I Diabetic Children
Authors: Claire Levy-Marchal, Marie-Pascale Bridel, Françoise Sodoyez-Goffaux, Michel Koch, Jean Tichet, Paul Czernichow, Jean-Claude Sodoyez
Journal: Diabetes Care (1991)

Objective Liquid- or solid-phase assays have been used for insulin autoantibody (IAA) determination, and the method of IAA measurement has not been standardized. Research Design and Methods IAAs were determined by radiobinding assay (RBA) and enzyme-linked immunosorbent assay (ELISA) in two large age-matched groups of nondiabetic and newly diagnosed insulin-dependent (type I) diabetic children. Results Positivity for IAA by RBA (≥ to nondiabetic mean + 3SD) was 2 of 178 (1.1%) and 55 of 173 (32%) in nondiabetic and diabetic children, respectively. Prevalence of IAA by RBA was significantly higher in the youngest age-group (63% between 0-4 yr). Positivity for IAA by ELISA was 1 of 178 (0.6%) and 8 of 169 (4.7%) in nondiabetic and diabetic children, respectively. Concordance rates between both assays were 0 of 3 (0%) in control subjects and 5 of 58 (8.6%) in diabetic children. Conclusions We conclude that RBA is more appropriate than ELISA for IAA detection at the onset of the disease. In addition, because available data suggest that IAAs detected by RBA only are high-affinity antibodies, it is tempting to speculate that IAAs reflect a mature immune reaction against endogenous insulin.
Association of Gastric Carcinoma with Idiopathic Late-Onset Immunoglobulin Deficiency
Authors: PAUL E. HERMANS
Journal: Annals of Internal Medicine (1972)

Among 39 patients with idiopathic late-onset immunoglobulin deficiency (LID) seen at the Mayo Clinic in the past 10 years, 3 had a concomitant carcinomatous gastric lesion (incidence, 7.7%). Two other cases of idiopathic LID and gastric carcinoma have been reported in the literature. The relationships among idiopathic LID, atrophic gastritis, pernicious anemia, malabsorption, and carcinoma of the stomach are discussed. Of special interest is that one of our patients developed myxedema because of primary thyroid failure.
Chronic Lymphocytosis with Lymphocyte Inclusions
Authors: JOHN M. NARDO
Journal: Annals of Internal Medicine (1972)

The lymphocytes of a patient with chronic lymphocytosis contained unique inclusions. The inclusions, composed of cytoplasmic bundles of straight, tubular structures measuring 120 Å to 150 Å in diameter, were found in more than 90% of the lymphocytes in peripheral blood and bone marrow. Histochemical and immunofluorescent studies did not identify their composition, although the inclusions occurred within rough endoplasmic reticulum, suggesting that they were largely composed of protein. The disease has had a benign course for 9 years, and no defects of cellular immunity have been found. This new and rare clinical state is probably a form of chronic leukemia. It is easily recognized by the presence of unique lymphocyte inclusions.
Phase 2 Study of Sorafenib in Malignant Mesothelioma Previously Treated with Platinum-Containing Chemotherapy
Authors: Sophie Papa, Sanjay Popat, Riyaz Shah, A. Toby Prevost, Rohit Lal, Blair McLennan, Paul Cane, Loic Lang-Lazdunski, Zaid Viney, Joel T. Dunn, Sally Barrington, David Landau, James Spicer
Journal: Journal of Thoracic Oncology (2013)
TRAVEL NOTES.I. TRAVEL AS A MEANS OF POST-GRADUATE MEDICAL EDUCATION.
Authors: NICHOLAS SENN
Journal: JAMA (1904)

For the second time I am on a tour around the world—this time in an opposite direction from East to West, via India. I leave San Francisco on the steamer<i>Sierra</i>, July 7, and if I am spared the disease-producing effects of the tropical climate and not delayed by failing to make timely connections, I expect to reach New York on the<i>Kronprinz Wilhelm</i>, October 11. Three years ago I girdled the globe via Siberia in three months and twenty days. That trip was replete with information of all sorts, general and professional, and the pleasure of it was enhanced by the companionship of my friends, Prof. D. R. Brower and Drs. Martin and Frank. I am very well aware, of the fact that midsummer is the wrong time to undertake a journey through India, owing to the intensity of the heat, but I expect to receive at least a partial
Abdominal Actinomycosis: Complication of Endoscopic Stenting in Chronic Pancreatitis?
Authors: I. A. Harsch, J. Benninger, G. Niedobitek, G. Schindler, H. T. Schneider, E. G. Hahn, G. Nusko
Journal: Endoscopy (2001)

Pancreatic endotherapy is frequently performed in patients with chronic pancreatitis and stenoses of the main pancreatic duct. In a patient with long-standing chronic pancreatitis and treatment with pancreatic stents, metastatic pancreatic head carcinoma was suspected because of infiltration of the neighboring organs and hepatic lesions. Ultrasound-guided aspiration of one liver lesion revealed grains typical for actinomycosis. In the light of this case, an extracted pancreatic stent was microbiologically investigated for actinomycetes in another patient who had a suspicious lesion of the pancreatic head. Microbiological examination of the extracted pancreatic stent revealed colonization by Actinomyces meyeri, Klebsiella oxytoca, and mixed cultures of anaerobic and saprophytic Gram-positive bacteria. In the following weeks, she developed a septic clinical picture with multiple abscesses of the liver. Actinomyces meyeri, Corynebacterium species, Candida and Enterococcae were cultivated in the aspirates. It seems possible, that treatment with pancreatic stents could have caused invasion of actinomycetes into the parenchyma of the pancreas, which was already harmed by the chronic inflammation, followed by the typical infiltrative growth and hematologic or biliary seeding into the liver.
The Physics of Radiation Therapy
Authors: Faiz M. Khan
Journal: JAMA (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
COMPLETENESS OF REVASCULARIZATION AND LONG TERM SURVIVAL IN PATIENTS ELIGIBLE FOR PERCUTANEOUS CORONARY INTERVENTION: A META-ANALYSIS OF MULTIVESSEL CORONARY ARTERY DISEASE STUDIES.
Authors: Vikas Aggarwal, Manjeet Singh, Swapnil Rajpathak, Atul M. Limaye, Benjamin Romick, Vankeepuram S. Srinivas
Journal: Journal of the American College of Cardiology (2010)
Granulocyte proteases do not process endothelial cell‐derived unusually large von willebrand factor multimers to plasma vWF in vivo
Authors: Martin D. Phillips, Chau Vu, Leticia Nolasco, Joel L. Moake
Journal: American Journal of Hematology (1991)

Abstract The unusually large von Willebrand factor (ULvWF) multimers present within endothelial cells and platelets are larger than the vWF multimers normally found in adult human plasma. Furthermore, ULvWF multimers are cleared rapidly from the circulation if they are released by intense endothelial cell stimulation. The mechanisms by which the ULvWF multimers are processed to large plasma vWF multimers are not known. It has been demonstrated that granulocyte proteases are capable of decreasing vWF multimer size in vitro, and that some patients with myeloproliferative syndromes have a relative absence of large plasma vWF multimers in sodium citrate‐anticoagulated plasma samples. In order to assess the influence of granulocyte proteases on vWF multimer size, we evaluated the vWF multimeric patterns in 94 plasma samples from 60 patients with neutrophil counts that were either considerably elevated or extremely reduced. In 83 of 94 plasma samples, the vWF multimeric patterns were normal. No patients with very low neutrophil counts had ULvWF multimers present. These observations suggest that granulocyte proteases are not likely to be involved in vivo in the processing of ULvWF multimers from endothelial cells to the smaller vWF forms in circulation.
Identification of cell surface receptors for the Act-2 cytokine.
Authors: M Napolitano, K B Seamon, W J Leonard
Journal: The Journal of Experimental Medicine (1990)

We have identified cell surface receptors for Act-2, a secreted protein expressed upon activation of T cells, B cells, and monocytes. Although 125I-Act-2 showed little, if any, specific binding to resting peripheral blood lymphocytes (PBL) receptors were readily detected on PHA/PMA-activated PBL and a variety of cell lines including MT-2, HL60, DMSO differentiated HL60, HeLa, and K562 cells. The equilibrium dissociation constant (Kd) is 3-12 nM for MT-2, K562, and PBL activated with PHA/PMA for 40-80 h. We have also identified a rabbit polyclonal antiserum that can block Act-2 binding to its receptors. The ability to detect specific Act-2 receptors and the development of a blocking antiserum should prove valuable in efforts to molecularly clone the Act-2 receptor and to dissect the biological actions of Act-2.
A second-generation virtual reality simulator for colonoscopy: validation and initial experience
Authors: A. Koch, J. Haringsma, E. Schoon, R. de Man, E. Kuipers
Journal: Endoscopy (2008)

See also: Commentaire de travail de A. D. Koch et al., pp. 735Endoscopy 2008; 40(09): 968-968DOI: 10.1055/s-0032-1306873
Prevalence of atopic dermatitis in Leicester: a study of methodology and examination of possible ethnic variation
Authors: R.L. NEAME, J. BERTH-JONES, J.J. KURINCZUK, R.A.C. GRAHAM-BROWN
Journal: British Journal of Dermatology (2006)

A study was undertaken to investigate and compare various methods of estimating the prevalence of atopic dermatitis (AD), and to investigate a possible ethnic difference in our local community. Preschool children attending routine child health surveillance clinics and Social Services day nurseries were examined by a trained observer, and their parents were interviewed. In addition, general practice records from a health centre were scrutinized. Three hundred and twenty‐two children aged 1–4 years were examined, and the point prevalence of AD was 14% [95% confidence interval (CI) 10–18]. There was no apparent ethnic difference in prevalence. Twenty‐seven per cent (95% CI 22–32) of parents reported that their children had suffered from'eczema' at some time. General practitioners' records contained a diagnosis of'eczema' in 32% (95% CI 28–36) of 446 children aged 1–4 years. It is clear that methodology must be carefully standardized if comparisons are to be made between different studies. Accurate estimations of the prevalence of AD can probably only be obtained by examination of a population sample by a trained observer. However, the estimates obtained in this study are high, and would tend to support existing evidence that the prevalence of AD is rising.
THE LONG–TERM OUTCOME OF S.M.A.R.T. VERSUS LUMINEXX NITINOL STENT IMPLAMTATION FOR AORTO–ILIAC ARTERY DISEASE
Authors: Yoshiaki Shintani, Yoshimitsu Soga, Osamu Iida, Daizo Kawasaki, Kenji Suzuki, Keisuke Hirano, Junichi Tazaki, Yusuke Miyashita, Tomohiro Kawasaki
Journal: Journal of the American College of Cardiology (2013)
Oxidative Stress–induced Antibodies to Carbonyl-modified Protein Correlate with Severity of Chronic Obstructive Pulmonary Disease
Authors: Paul A. Kirkham, Gaetano Caramori, Paolo Casolari, Alberto A. Papi, Matt Edwards, Betty Shamji, Kostas Triantaphyllopoulos, Farhana Hussain, Mariona Pinart, Younis Khan, Lucy Heinemann, Laurie Stevens, Mike Yeadon, Peter J. Barnes, Kian F. Chung, Ian M. Adcock
Journal: American Journal of Respiratory and Critical Care Medicine (2011)

Rationale: There is increasing evidence for the presence of autoantibodies in chronic obstructive pulmonary disease (COPD). Chronic oxidative stress is an essential component in COPD pathogenesis and can lead to increased levels of highly reactive carbonyls in the lung, which could result in the formation of highly immunogenic carbonyl adducts on "self" proteins.Objectives: To determine the presence of autoantibodies to carbonyl-modified protein in patients with COPD and in a murine model of chronic ozone exposure. To assess the extent of activated immune responses toward carbonyl-modified proteins.Methods: Blood and peripheral lung were taken from patients with COPD, age-matched smokers, and nonsmokers with normal lung function, as well as patients with severe persistent asthma. Mice were exposed to ambient air or ozone for 6 weeks. Antibody titers were measured by ELISA, activated compliment deposition by immunohistochemistry, and cellular activation by ELISA and fluorescence-activated cell sorter.Measurements and Main Results: Antibody titer against carbonyl-modified self-protein was significantly increased in patients with Global Initiative for Chronic Obstructive Lung Disease stage III COPD compared with control subjects. Antibody levels inversely correlated with disease severity and showed a prevalence toward an IgG1 isotype. Deposition of activated complement in the vessels of COPD lung as well as autoantibodies against endothelial cells were also observed. Ozone-exposed mice similarly exhibited increased antibody titers to carbonyl-modified protein, as well as activated antigen-presenting cells in lung tissue and splenocytes sensitized to activation by carbonyl-modified protein.Conclusions: Carbonyl-modified proteins, arising as a result of oxidative stress, promote antibody production, providing a link by which oxidative stress could drive an autoimmune response in COPD.
Pulmonary Tumor Thrombotic Microangiopathy
Authors: Yoshiko Tashima, Koichiro Abe, Yoshio Matsuo, Shingo Baba, Koichiro Kaneko, Takuro Isoda, Hidetake Yabuuchi, Masayuki Sasaki, Hiroshi Honda
Journal: Clinical Nuclear Medicine (2009)

Pulmonary tumor thrombotic microangiopathy (PTTM) is histopathologically characterized by proliferation of intimal myofibroblasts in the small pulmonary arterioles, induced by tumor microemboli. Patients develop rapidly progressive and severe cardiopulmonary failure, and the clinical course of this disease is fatal. Conventional radiologic findings are often minimal or nonspecific, making diagnosis difficult before death. We report 2-(F-18)-fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET) images of PTTM, which illustrate the characteristic findings of this clinical entity. FDG-PET can be helpful for the diagnosis of PTTM.
TCTAP A-074 Five-year Clinical Outcomes of Drug Eluting Stents According to the On-label and Off-label Usage
Authors: Jeong-Hwan Cho, Chan-Hee Lee, Hyun-Wook Lee, Tae-Hun Kwon, Yoon-Jung Choi, Jang-Won Son, Sang-Hee Lee, Ung Kim, Jeon-Seon Park, Dong-Gu Shin, Young-Jo Kim
Journal: Journal of the American College of Cardiology (2014)
Medical Advice My Friend Got
Authors: WILLIAM A. NEILL
Journal: Annals of Internal Medicine (1982)

Ad Libitum1 August 1982Medical Advice My Friend GotWILLIAM A. NEILL, M.D.WILLIAM A. NEILL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-97-2-279 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptYou wouldn't guess that my friend inherited the business, the way he fusses over its every detail, as if he had brought it up from seed. He isn't like some others who settle easily into their good fortune, drift along successfully enough but leave you wondering how they'd have made their way under any other circumstances. His father, whom I didn't know, is said to have been the source of the family work ethic. Drilled it into his son (as if that were necessary—the heredity alone was enough), then died young. Worked himself to death was the judgment I can... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1982Volume 97, Issue 2Page: 279-279KeywordsHeredity ePublished: 1 December 2008 Issue Published: 1 August 1982 PDF downloadLoading ...
Effects of pericardiectomy on canine pulmonary blood volume during hypervolaemia
Authors: M. C Gerson, M. Gabel, N. O Fowler, M. White
Journal: Cardiovascular Research (1991)

Study objective — The aim was to determine the effect of the pericardium on the pulmonary blood volume response to intravascular volume loading. Design — Changes in pulmonary lung volume were measured from radioactive counts over the lung during radionuclide ventriculography. Baseline measurements, and repeat measurements after infusion of 21 ml·kg−1 of the dog's own blood, were made both before and after a pericardiectomy. Subjects — Ten closed chest, anaesthetised dogs were studied. Measurements and main results — Prior to and following pericardiectomy, volume loading produced equivalent and significant increases in left atrial, mean pulmonary artery, and right atrial pressures (all p<0.05). Before pericardiectomy, radionuclide lung counts increased from 1606(SEM 348) to 1870(402) with volume loading, corresponding to a 16% rise in lung counts from baseline (p<0.05). Following pericardiectomy, a similar volume load did not result in a significant rise in lung counts [1588(245) to 1697(255), 9%, p = 0.16], but was accompanied by an increase in left ventricular diastolic volume, from 39.7(6.6) to 58.7(6.4) ml, p<0.05, and a decrease in systemic vascular resistance index, from 122600(14600) to 86600(10000) dynes·s·cm−5 × kg, p<0.05. Conclusions — These data support the concept that removal of the pericardium is accompanied by reduced pulmonary blood volume overload in response to intravascular volume loading. The mechanism appears to be related to improved left ventricular diastolic filling, perhaps the result of diminished ventricular interaction, and to redistribution of excess intravascular volume from the pulmonary to the systemic circuit.
Percutaneous Cardiac Recirculation-Mediated Gene Transfer of an Inhibitory Phospholamban Peptide Reverses Advanced Heart Failure in Large Animals
Authors: David M. Kaye, Arthur Preovolos, Tanneale Marshall, Melissa Byrne, Masahiko Hoshijima, Roger Hajjar, Justin A. Mariani, Salvatore Pepe, Kenneth R. Chien, John M. Power
Journal: Journal of the American College of Cardiology (2007)
Plasmacytoid DCs regulate recall responses by rapid induction of IL-10 in memory T cells
Authors: Espen O. Kvale, Yngvar Fløisand, Fridtjof Lund-Johansen, Halvor Rollag, Lorant Farkas, Smita Ghanekar, Per Brandtzaeg, Frode L. Jahnsen, Johanna Olweus
Journal: Blood (2006)
Contemporary Themes: Congenital Malformations and the Problem of their Control
Authors: C. R. Lowe
Journal: BMJ (1972)

The possibility of preventing or reducing the prevalence of human congenital malformations is discussed in the light of current knowledge about their aetiology. The original data presented are derived from an epidemiological study of all the infants (92,982) born in the three years 1964-6 to women resident in a defined area of South Wales and all the congenital malformations (3,242) discovered in those infants by the second anniversary of their birth.
Effects of uremia and inflammation on growth hormone resistance in patients with chronic kidney diseases
Authors: Giacomo Garibotto, Rodolfo Russo, Antonella Sofia, Diego Ferone, Fulvio Fiorini, Valeria Cappelli, Alice Tarroni, Maria Teresa Gandolfo, Emanuela Vigo, Alessandro Valli, Marica Arvigo, Daniela Verzola, Giovanbattista Ravera, Francesco Minuto
Journal: Kidney International (2008)