tbuckley/cabot-search huggingface dataset:
Abstract P3-15-06: No Correlation between Endocrine Symptoms and Musculoskeletal Symptoms in Women Receiving Adjuvant Aromatase Inhibitor Therapy
Authors: T Cigler, O Singer, A Moore, E Chuang, L Vahdat, B Reichman, AB Levine, HT Do, LA. Mandl
Journal: Cancer Research (2010)

Abstract Background: The etiology of Aromatase Inhibitor (AI) associated musculoskeletal symptoms remains unclear. It has been proposed that musculoskeletal side effects are related to the estrogen depletion achieved on AI therapy. Estrogen depletion with AI therapy is known to result in endocrine side effects. The 18-item Functional Assessment of Cancer Therapy Breast Cancer-Endocrine Subscale (FACTB-ES) is a reliable and well validated quality of life questionnaire shown to be sensitive to changes in endocrine symptoms in breast cancer patients. The objective of this study was to determine whether among women with breast cancer treated with adjuvant AI therapy, self reported musculoskeletal side effects correlate with increased hormonal side effects as measured by the FACTB-ES. Methods: In this 6 month, single center, prospective cohort study, post-menopausal women with hormone-sensitive, non-metastatic breast cancer prescribed AIs by their treating oncologist were evaluated by a rheumatologist at baseline (before starting the AI) and at 6 months. Women who reported new or worsening musculoskeletal symptoms since starting the AI were classified as symptomatic. The FACTB-ES was administered at each visit. Changes in scores between baseline and 6 months were compared between the symptomatic and asymptomatic groups Results: Thirty-five subjects completed the 6 month follow up period. Nineteen (54%) were symptomatic and n=2 (5.7%) discontinued the AI due to these musculoskeletal symptoms. Mean time to onset of symptoms was 6 weeks (range 2 to 18 weeks). Baseline characteristics including age, ethnicity and body mass index did not differ between the groups. There was no significant difference in hormonal symptoms between groups. Both groups had equivalent worsening of their endocrine symptoms as seen by the reduction in their FACTB-score. The mean change in FACTB-ES score was -2.52 (range: -31.00, 23.00) in the symptomatic women versus -2.06 (range: -19.00, 22.21) in the asymptomatic women (Wilcoxon rank sum p=0.95). Conclusions: These data suggest that endocrine symptoms as measured by the FACTB-ES do not correlate with the development of musculoskeletal pain in women treated with adjuvant AI therapy for breast cancer. Though larger studies are necessary to confirm these results, the musculoskeletal symptoms associated with AI use may not be estrogen-dependent. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr P3-15-06.
The Role of<i>Copy-and-Paste</i>in the Hospital Electronic Health Record
Authors: Ann M. Sheehy, Daniel J. Weissburg, Shannon M. Dean
Journal: JAMA Internal Medicine (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Prevalence of Mitochondrial 1555A→G Mutation in Adults of European Descent
Authors: Himesha Vandebona, Paul Mitchell, Neil Manwaring, Kate Griffiths, Bamini Gopinath, Jie Jin Wang, Carolyn M. Sue
Journal: New England Journal of Medicine (2009)

To the Editor: Sensorineural hearing loss is the most common type of sensory impairment worldwide.1 We have found that pathogenic mitochondrial DNA (mtDNA) mutations, such as the m.3243A→G mutation...
Letter: Infection after insertion of I.U.D.
Authors: W Mills
Journal: BMJ (1975)

It seems clear that the only spastic infant in our series would have been equally likely to be handicapped had it been delivered by caesarean section and, in our hands, prolonged resuscitation did not keep alive spastics caused by the mode of delivery, so depressing our perinatal loss rate.I thank Mr. E. 0.
Age, Increased Left Ventricular Mass, and Lower Regional Myocardial Perfusion Are Related to Greater Extent of Myocardial Dyssynchrony in Asymptomatic Individuals
Authors: Boaz D. Rosen, Veronica R.S. Fernandes, Khuram Nasir, Thomas Helle-Valle, Michael Jerosch-Herold, David A. Bluemke, Joao A.C. Lima
Journal: Circulation (2009)

Age and left ventricular (LV) hypertrophy are risk factors for the development of LV dysfunction and congestive heart failure. Our goal was to study the relationships of LV mass and age with myocardial dyssynchrony among asymptomatic participants of the Multi-Ethnic Study of Atherosclerosis.A total of 1100 individuals underwent tagged magnetic resonance imaging. Regional LV function was analyzed with the use of harmonic phase imaging. Time to peak systolic circumferential strain and strain rate were measured in 12 segments, and myocardial dyssynchrony was expressed as the SD of time to peak strain and strain rate. Relationships of age, LV mass, and myocardial perfusion with timing of strain, strain rate, and dyssynchrony were studied. There was a positive relationship between age and time to peak strain before (regression coefficient=0.37 ms/year of age; 95% confidence interval, 0.05 to 0.70; P=0.025) and after adjustment for demographic characteristics and risk factors (P=0.007). Positive associations between age and SD of time to peak strain (regression coefficient=0.33 ms/year of age; P=0.002) and SD of time to peak systolic strain rate were documented (P=0.045). Importantly, we found that LV mass index is directly related to time to peak strain (P<0.001), time to peak strain rate, and the SD of time to strain rate (P=0.001 for all). Finally, decreased myocardial perfusion at rest was associated with delayed contraction and increased extent of dyssynchrony.In asymptomatic individuals, age, increased LV mass, and decreased myocardial perfusion are related to delayed myocardial contraction and greater extent of dyssynchrony. Increased dyssynchrony may mediate the association of myocardial dysfunction with age and LV hypertrophy.
ABC of labour care: Unusual presentations and positions and multiple pregnancy
Authors: G. Chamberlain, P. Steer
Journal: BMJ (1999)

In the vast majority of deliveries near term the fetus presents by the head, with the best fit into the lower pelvis in the occipito-anterior position. However, although the head is presenting, it may be not in an occipito-anterior but in an occipito-posterior or transverse position. In a few cases the head is grossly deflexed so that the brow or even the face can present.

In other instances, it is not the head that is at the lower pole of the uterus but the buttocks, or breech (from the old English brec—breeches or buttocks). The fetus many even lie transversely so that no pole is in relation to the pelvic inlet. A fetus in this position is undeliverable vaginally; both transverse lies and breech presentations are much more common if the woman enters labour in the earlier weeks of pregnancy (22-28 weeks of gestation).



Fetal head engages in left occipito-anterior position (top) then descends into mid-cavity and rotates to full occipito-anterior (bottom)



All these malpresentations and malpositions need careful diagnosis and skilful management.

### Normal mechanism

Usually the fetal head engages in the left (less commonly, right) occipito-anterior position and then undergoes a short rotation to be directly occipito-anterior in the mid-cavity.



If, instead of the normal curve, the sacrum is straightened (shaded area), the anterior-posterior diameter in mid-cavity is reduced (A-A), thus hindering head rotation in this zone



### Occipito-posterior position

This is the commonest malpresentation. The head engages in the left or right occipito-transverse position, and the occiput rotates posteriorly, rather than into the more favourable occipito-anterior position. The reasons for the malrotation are often unclear. A flat sacrum or a head that is poorly flexed may be responsible; alternatively, poor uterine contractions may not push the head down into the pelvis strongly enough to produce correct rotation; epidural analgesia might sometimes relax the …
On Clinical Alerts
Authors: Vincent T. DeVita
Journal: Annals of Internal Medicine (1991)

Letters1 August 1991On Clinical AlertsVincent T. DeVita Jr., MDVincent T. DeVita Jr., MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-115-3-234_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors:I am writing to offer a correction to a statement made by Drs. Suzanne and Robert Fletcher in a recent issue (1). In the third paragraph, where the Editors discuss the "track record" of prepublication releases, they refer to the first clinical alert issued by the National Cancer Institute, saying that it urged adjuvant therapy for patients with nodenegative breast cancer. They further comment that a subsequent consensus development conference in 1990 issued quite a different recommendation: more research. Although this is a common misconception of the purpose of the original clinical alert, it was, in fact,...References1. FletcherFletcher SR. Early release of research results. Ann Intern Med. 1991;114:698-700. LinkGoogle Scholar2. DeVita V. The "clinical alert" from the National Cancer Institute. N Engl J Med. 1988;319:948-9. CrossrefMedlineGoogle Scholar3. DeVita V. Is a mechanism such as the NCI's clinical alert ever an appropriate alternative to journal peer review? In: Devita VT, Hellman S, Rosenberg SA; eds. Important Advances in Oncology. Philadelphia: J. B. Lippincott; 1991:241-6. Google Scholar1. NCI Clinical Alert on Breast Cancer. May, 1988. Google Scholar2. NIH Concensus Conference. Treatment of early-stage breast cancer. JAMA. 1991;265:391-5. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Memorial Sloan-Kettering Cancer Center New York, NY 10021 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1991Volume 115, Issue 3Page: 234-235KeywordsBreast cancer Issue Published: 1 August 1991 PDF DownloadLoading ...
Mechanisms of thrombocytopenia in varicella
Authors: James H. Feusner, Sherrill J. Slichter, Laurence A. Harker
Journal: American Journal of Hematology (1979)

Abstract 51 Cr‐labeled platelet and 125 I‐labeled fibrinogen kinetic studies in four thrombocytopenic children with varicella infection revealed marked platelet destruction (platelet survival times 0.1, 0.4, 1.0, and 2.4 days) and relatively normal fibrinogen disappearance. The platelet count was directly related to the platelet survival time. Marrow megakaryocyte mass was increased twofold to fourfold. IgG or IgM antiplatelet antibody was present on autologous platelets in the three patients tested. These data suggest that thrombocytopenia in some patients with varicella is the consequence of immune mediated platelet destruction.
Autoregulation of NFATc1/A Expression Facilitates Effector T Cells to Escape from Rapid Apoptosis
Authors: Sergei Chuvpilo, Eriks Jankevics, Dimitri Tyrsin, Askar Akimzhanov, Denis Moroz, Mithilesh Kumar Jha, Jan Schulze-Luehrmann, Brigitte Santner-Nanan, Elizaveta Feoktistova, Thomas König, Andris Avots, Edgar Schmitt, Friederike Berberich-Siebelt, Anneliese Schimpl, Edgar Serfling
Journal: Immunity (2002)
Cigarette Smoking and Hepatic Lesions in Patients With Chronic Hepatitis C
Authors: Fabienne Pessione, Marie-José Ramond, Corinne Njapoum, Véronique Duchatelle, Claude Degott, Serge Erlinger, Bernard Rueff, Dominique-Charles Valla, Françoise Degos
Journal: Hepatology (2001)

A possible hepatotoxicity of cigarette smoke has been recently suggested by epidemiological and experimental studies. Our aim was to study the possible relationships between smoking and liver fibrosis and activity in patients with chronic hepatitis C. A cross-sectional study was performed in a group of 310 patients with chronic hepatitis C consecutively hospitalized for their first liver biopsy. The relationships between age, gender, alcohol consumption, route of contamination, tobacco consumption, and Knodell fibrosis and activity scores were examined in univariate, age-adjusted, and multivariate analyses. One hundred and seventy-six patients (57%) were current smokers. Smokers were younger (P <.001), more often of male gender (P =.001), more often alcohol consumers (P =.001), and more often had a history of intravenous drug use (P =.0001) than never smokers. Smoking was related to increased fibrosis and activity scores in age-adjusted (P =.009 and P =.005, respectively) and multivariate analyses (P =.03 and P =.04, respectively). Smoking increases the severity of hepatic lesions in patients with chronic hepatitis C.
Treatment of Gold Dermatitis by BAL
Authors: N. R. W. Simpson
Journal: BMJ (1948)

MEDICAL JOURNAL depression for 30 seconds.Intraperitoneal reduction of the intussusception was impossible and resection of a portion of the gut with end-to-end anastomosis was undertaken.At 38 minutes a further dose of 1 ml.was administered.Operation was con- cluded at 57 minutes.Only small quantities of ether were employed from time to time to maintain anaesthesia in the first plane, and the child started to cry while the skin was being sutured.Death occurred five hours later.Case 7.-Intussusception.Aged 71 months.Weight, 19 lb.(8.62 kg.).Induction and maintenance with open ether.Myanesin 2 ml.into the longitudinal sinus at six minutes.There was slight respiratory depression for five minutes.Operation con- cluded at 14 minutes.No ether was administered after the myanesin had been given.Relaxation was excellent.Recovery uneventful.Case 8.-Intussusception.Aged 11 months.Weight, 18 lb.8 oz.(8.39 kg.).Induction and maintenance with open ether.Myanesin 2 ml. at 13 minutes into the longitudinal sinus.Operation concluded at 33 minutes.No ether administered after the peritoneum was opened.Relaxation was excellent.Recovery uneventful.Case 9.-Appendix abscess for 48 hours.Aged 1 year 10 months.General condition bad.Induction and maintenance with open ether.Myanesin 3.5 ml.into the intravenous drip saline at two minutes, and a further dose of 1.2 ml. at 16 minutes.Operation concluded at 32 minutes.There was no respiratory depression, but relaxation was not quite so good as usual.Death occurred from peritonitis on the fifth day.Case 10.-Appendicitis.Aged 3 years 11 months.Induction with ethyl chloride, maintenance with open ether.Myanesin 5 ml. at three minutes.Operation concluded at 16 minutes.There was no respiratory depression.No ether was administered after the peritoneum was opened.Relaxation was good.Recovery was uneventful.Case 11.-Appendicitis with abscess.Aged 4 years 6 months.Temperature, 1030 F. (39.4°C.).Pulse, 150 before operation.Induction with nitrous oxide, maintenance with open ether.Myanesin 3 ml.at three minutes and 1.5 ml. at 23 minutes.Operation concluded at 33 minutes.Small quantities of ether were required,from time to time.There was no alteration in the pulse rate during operation and no respiratory depression.Relaxation was good.Recovery uneventful.
Role of endogenous atrial natriuretic peptide in DOCA-salt hypertensive rats. Effects of a novel nonpeptide antagonist for atrial natriuretic peptide receptor.
Authors: Y Hirata, H Matsuoka, E Suzuki, H Hayakawa, T Sugimoto, Y Matsuda, Y Morishita, K Kangawa, N Minamino, H Matsuo
Journal: Circulation (1993)

BACKGROUND To explore roles of endogenous atrial natriuretic peptide (ANP) in blood pressure and volume regulation, we examined the effects of a newly developed ANP antagonist, HS-142-1 (HS) in deoxycorticosterone acetate (DOCA)-salt hypertensive rats. METHODS AND RESULTS We examined 1) the effects of HS on ANP- or brain natriuretic peptide (BNP)-induced reductions in renal vascular resistance (RVR) of rat isolated perfused kidneys, 2) the effects of HS on cyclic GMP (cGMP) production in rat cultured vascular smooth muscle cells pretreated with ANP or BNP, and 3) the renal and systemic effects of HS in DOCA-salt-treated rats and control rats. We found that 1) HS dose-dependently reversed ANP- or BNP-induced decreases in RVR; 2) ANP or BNP at 100 nM caused an eightfold increase in cGMP production. These increases in cGMP were inhibited by HS in a dose-dependent fashion, and 300 micrograms/ml HS decreased cGMP to the control level. HS alone did not influence RVR or cGMP production; and 3) DOCA-salt rats showed higher plasma concentrations of ANP (198 versus 75 pg/ml) and BNP (23.7 versus 2.7 pg/ml, each p &lt; 0.01) than the control rats. Bolus administration of 8 mg/kg HS elevated blood pressure by 8% (p &lt; 0.01). This rise in blood pressure was attributed to an increase in systemic vascular resistance (+14%, p &lt; 0.05). Conversely, urinary excretion of sodium (-41%), glomerular filtration rate (-27%), and plasma (-77%) and urinary cGMP (-69%, each p &lt; 0.01) were decreased by administration of 8 mg/kg HS. These effects were dose dependent in DOCA-salt rats but slight or negligible in the control rats. CONCLUSIONS These results suggest that endogenous ANP and BNP may be involved in the regulation of blood pressure and body fluid volume in DOCA-salt rats in which ANP and BNP secretion is augmented.
Autoimmune haemolysis in unexpectedly mild sickle cell/hemoglobin C disease
Authors: Deena Iskander, Emma O'Donovan, Barbara J. Bain
Journal: American Journal of Hematology (2013)

An 82-year-old woman of Afro-Caribbean origin was hospitalized with acute confusion and sepsis. Her past medical history included a colectomy for carcinoma of the colon, an ischemic stroke at the age of 71 years and compound heterozygosity for hemoglobin S and hemoglobin C. Other than a possible relationship to the stroke, there was no history of complications of the sickle cell/hemoglobin C disease. On admission, chest radiography showed a lobar pneumonia and urine culture showed mixed bacterial growth. In addition, an acute inferior myocardial infarction was diagnosed on the basis of electrocardiograph findings and a raised troponin I of 12.73 µg/l (normal less than 10). The full blood count on admission showed: hemoglobin concentration (Hb) 95 g/l, white blood cell count 17.7 x 109/l, neutrophil count 14.2 x 109/l, mean cell volume 78.8 fl, mean cell haemoglobin concentration 357 g/l, red blood cell distribution width 21.4% and platelet count 121 x 109. The blood film showed a leucoerythroblastic picture, which was attributed to sepsis. The patient was treated with intravenous antibiotics and her confusion resolved. One week after admission the Hb had fallen to 74 g/l. A blood film was re-examined and showed inconspicuous features of sickle cell disease including occasional target cells, boat-shaped cells and pointed poikilocytes (left). Hyposplenic features and classical sickle cells were absent. However spherocytes (left), red cell agglutinates (right) and polychromasia were seen, suggestive of immune hemolysis. This possibility was further supported by a positive direct antiglobulin test (2+, immunoglobulin G), reticulocyte count of 189 x 109, bilirubin of 24 µmol/l (normal less than 17) and lactate dehydrogenase of 930 iu/l (normal less than 243). Antinuclear antibodies were present at a dilution of 1/160 with a fine speckled pattern and double-stranded DNA antibodies were positive at 95 iu/ml (normal less than 30 iu/ml). In view of her previous medical history, computed tomography virtual colonoscopy was carried out and showed a spleen of normal size with subcapsular calcification. The patient underwent percutaneous coronary stenting of the right coronary artery. Following the fall of Hb, she was transfused with one unit of red cells and folic acid was commenced. The Hb stabilised without requiring corticosteroids and three months later was 108 g/l. This case of immune-mediated hemolysis highlights the unexpected extra information that may be gained from a blood film when a patient with sickle cell disease suffers a fall of Hb. It also illustrates that sickle cell/haemoglobin C disease is sometimes very mild. The very minor blood film features and the preservation of splenic function are concordant with her unusually mild clinical phenotype. This is the oldest patient we have seen with this compound heterozygous state condition but in fact the median survival in women is as high as 68 years 1.
451 Comparison of liver functional parameters with serum fibrosis markers as predictors of secere necro-inflammation in patients with chronic hepatitis B and D
Authors: C. Yurdaydin, M. Toruner, H. Bozkaya, A. Okcu-Heper, M. Voelker, E. Erden, M.A. Bozdayi, O. Uzunalimoglu, D. Schuppan
Journal: Journal of Hepatology (2004)
Hypusination of eukaryotic initiation factor 5A (eIF5A): a novel therapeutic target in BCR-ABL–positive leukemias identified by a proteomics approach
Authors: Stefan Balabanov, Artur Gontarewicz, Patrick Ziegler, Ulrike Hartmann, Winfried Kammer, Mhairi Copland, Ute Brassat, Martin Priemer, Ilona Hauber, Thomas Wilhelm, Gerold Schwarz, Lothar Kanz, Carsten Bokemeyer, Joachim Hauber, Tessa L. Holyoake, Alfred Nordheim, Tim H. Brümmendorf
Journal: Blood (2006)