tbuckley/cabot-search huggingface dataset:
"Swiss-Cheese" Platelets
Authors: JORGE E. MALDONADO
Journal: Annals of Internal Medicine (1974)

Comments and Corrections1 December 1974"Swiss-Cheese" PlateletsJORGE E. MALDONADO, M.D., PH.D., F.A.C.P.JORGE E. MALDONADO, M.D., PH.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-81-6-860_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Two reports (1, 2) have recently appeared in the Annals of Internal Medicine concerning platelets with a widely dilated open canalicular system and the ultrastructural appearance described by the term "Swiss-cheese" platelets. In the first paper (1), a patient with a mild bleeding tendency had giant and vacuolated platelets. Initially this patient had laboratory features of thrombasthenia, with later changes more consistent with thrombopathia. More recently, Davis (2) reported that Swiss-cheese platelets could be induced experimentally in rats by injection of lead acetate, and he illustrated similarly vacuolated platelets from a case of familial thrombocytopenia.In electron...References1. SMITHDODDSTARTAGLIA TWA: Thrombasthenic-thrombopathic thrombocytopenia with giant, "Swiss-cheese" platelets: a case report. Ann Intern Med 79:828-834, 1973 LinkGoogle Scholar2. DAVIS R: "Swiss-cheese" platelets. Ann Intern Med 80:776, 1974 LinkGoogle Scholar3. BITHELLPAREKHSTRONG TSR: Platelet-function studies in the Bernard-Soulier syndrome. Ann NY Acad Sci 201:145-160, 1972 CrossrefMedlineGoogle Scholar4. MALDONADOBRIGDEN JL: A distinct anomaly of the platelet granules in refractory anemia and myelomonocytic leukemia: a preliminary communication. Thromb Diath Haemorrh (suppl). In press Google Scholar5. MALDONADO J: The ultrastructure of platelets in refractory anemia ("preleukemia") and myelomonocytic leukemia. Ser Haematol. In press Google Scholar6. CRAWFORDSUTTONHORSFIELD NMG: Platelets in the carcinoid syndrome: a chemical and ultrastructural investigation. Br J Haematol 13:181-188, 1967 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JORGE E. MALDONADO, M.D., PH.D., F.A.C.P.Affiliations: Mayo Clinic and Mayo Foundation Rochester, Minnesota 55901 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCongenital dysgranulopoietic neutropeniaThrombocytopenic purpura with giant platelets and ultrastructural platelet defectsHaemorrhagic Thrombocytopathy Associated with Dilatation of the Platelet-Membrane Complex 1 December 1974Volume 81, Issue 6Page: 860-861KeywordsHemorrhagePlateletsResearch laboratories ePublished: 1 December 2008 Issue Published: 1 December 1974 PDF downloadLoading ...
Civil Service in State Institutions.
Authors: Boerne Bettman
Journal: JAMA (1895)

Chicago, Ill., Jan. 8, 1895. <h3>To the Editor:</h3> —The readers of theJournal of the American Medical Associationwill no doubt be interested to learn that an attempt will be made to introduce into our State institutions a system of civil service reform in the formation of the medical staff. The affixed circular letter was recently sent to the trustees of the four insane asylums. The matter will be thoroughly discussed at an approaching meeting of the superintendents of the insane hospitals and the President of the State Board of Charities. The competitive examination will be impartial and no doubt patterned after that at the Cook County Hospital. Yours truly,
Attributed Responsibility for Life Events in Survivors of Myocardial Infarction
Authors: D.G. Byrne
Journal: Psychotherapy and Psychosomatics (1980)

The direction of attributed responsibility for the occurrence of stressful life events in the year prior to illness onset was examined for 120 survivors of myocardial infarction and 40 patients with chest pain but without myocardial infarction. Additionally, feelings of helplessness in response to the same events were examined to collectively test the hypothesis that patients with the more serious illness of myocardial infarction would see responsibility for stressful life events as lying primarily with sources other than themselves, and would thereby be characterized by feelings of helplessness. The two groups were not significantly different on measures of responsibility, but patients with myocardial infarction reported significantly greater feelings of helplessness than the other group. This, together with a significant negative correlation between helplessness and self-responsibility, and significant positive correlations between other and chance responsibility, was considered to give firm but indirect support to the hypothesis.
Gated SPECT Findings Revealing Diastolic Dysfunction in Acute Hypothyroidism
Authors: Mehmet Aydin, Mehmet Reyhan, Aysun Sukan, A Fuat Yapar, Ayse Aktas
Journal: Clinical Nuclear Medicine (2007)

The purpose of this study was to assess left ventricular (LV) function by gated SPECT in acute hypothyroidism.Thirty-eight acute hypothyroid patients without any cardiac disease and 40 healthy controls underwent gated SPECT at rest. Fourteen patients had a second examination during thyroxine replacement therapy. Gated SPECT was performed using Tc-99m sestamibi with 16 frames per cardiac cycle. The LV end-diastolic volume (EDV), end-systolic volume (ESV), ejection fraction (EF), peak ejection rate (PER), peak filling rate (PFR), and time to peak filling (TTPF) were measured by quantitative gated SPECT (QGS). Systolic wall thickening/motion was determined in 5 myocardial segments.Hypothyroid patients exhibited a decrease in PFR (222 +/- 52 EDV/s) and prolongation of TTPF (194 +/- 32 msec) as compared with controls (247 +/- 41 EDV/s and 179 +/- 17 msec, respectively; P < 0.05). During thyroxine therapy, the mean values for EDV (74 +/- 21 mL) and PFR (265 +/- 64 EDV/s) increased significantly in 14 follow-up patients (pretreatment values 67 +/- 18 mL and 219 +/- 50 EDV/s, respectively; P < 0.05). A significant difference was detected in the mean TTPF between the thyroxine group and the controls (195 +/- 35 msec vs 179 +/- 17 msec; P < 0.05). No significant differences were found in wall thickening and motion values (P > 0.05).Gated SPECT findings revealed diastolic dysfunction as indicated by a decrease in PFR and a prolongation in TTPF in patients with acute hypothyroidism.
Regional Myocardial Metabolic Rate of Oxygen Measured by O2-15 Inhalation and Positron Emission Tomography in Patients with Cardiomyopathy
Authors: DENIS AGOSTINI, HIDEHIRO DA, AKIRA TAKAHASHI, YOSHIKAZU TAMURA, MICHEL HENRY AMAR, YUKIHIRO ONO
Journal: Clinical Nuclear Medicine (2001)

Positron emission tomography (PET) metabolic studies have investigated the pathways involved in fatty acid, glucose, and oxidative metabolism in cardiomyopathy and the impairments that occur in the damaged myocardium, but none have provided absolute quantitative variables. Recently, quantitative measurements of the metabolic rate of oxygen (MMRO2) and oxygen extraction fraction (OEF) using O2-15-labeled oxygen gas have been validated in animals and healthy volunteers. The purposes of the current study were to measure MMRO2 and OEF in cardiomyopathy with left ventricular (LV) dysfunction.The authors selected 25 study participants: 16 patients (10 with ischemic and 6 with dilated) cardiomyopathy with LV dysfunction, and 9 healthy volunteers. As evaluated by echocardiography, LV ejection fraction (LVEF) was decreased in patients (35%+/-9% vs. 65%+/-5%, P<0.01). The PET protocol consisted of transmission, C O2-15 static, H2 O-15 dynamic, and O2-15 gas inhalation steady state scans. An entire myocardial region of interest was drawn to encompass the entire LV myocardium on three midventricular slices in each participant.Data showed in patients with dilated cardiomyopathy significant reductions of MMRO2 (0.051+/-0.02 ml x min(-1) x g(-1) vs. 0.108+/-0.02 ml x min(-1) x g(-1), p = 0.01) and OEF (0.55+/-0.15 vs. 0.71+/-0.08, P = 0.01) when compared with healthy volunteers. Furthermore, OEF decreased significantly in lateral and inferior walls. Significant correlations were observed among OEF and the rate-pressure product (RPP) (P = 0.02), LVEF (P<0.001), MMRO2 and RPP (P = 0.04), and LVEF (P = 0.05). In patients with ischemic cardiomyopathy, MMRO2 was significantly reduced (0.039+/-0.02 ml x min(-1) x g(-1) vs. 0.108+/-0.02 ml x min(-1) x g(-1); p = 0.005) but not OEF (0.63+/-0.2 vs. 0.71+/-0.08; P = NS), when compared with healthy volunteers. Significant correlations were observed among OEF and RPP (P = 0.03), LVEF (P = 0.002), MMRO2 and RPP (P<0.01), and LVEF (P = 0.03).These data show that O2-15 gas inhalation and PET allow myocardial MMRO2 and OEF to be measured in patients with cardiomyopathy.
Neonatal pemphigus vulgaris with extensive mucocutaneous lesions from a mother with oral pemphigus vulgaris
Authors: A. Campo-Voegeli, F. Muniz, J.M. Mascaro, M. Casals, F. Garcia, J.L. Arimany, M. Amagai, A. Camps
Journal: British Journal of Dermatology (2002)

Journal Article Neonatal pemphigus vulgaris with extensive mucocutaneous lesions from a mother with oral pemphigus vulgaris Get access A. Campo‐Voegeli, A. Campo‐Voegeli Departments of Dermatology Dr Antonio Campo‐Voegeli. E‐mail: acampov@medynet.com Search for other works by this author on: Oxford Academic Google Scholar F. Muñiz, F. Muñiz Paediatrics and Search for other works by this author on: Oxford Academic Google Scholar J.M. Mascaró, Jr, J.M. Mascaró, Jr Department of Dermatology, Hospital Clínic, University of Barcelona School of Medicine, Barcelona, Spain Search for other works by this author on: Oxford Academic Google Scholar M. Casals, M. Casals Departments of Dermatology Search for other works by this author on: Oxford Academic Google Scholar F. García, F. García Pathology, Hospital General de Catalunya, C/Gomera s/n, 08190 Sant Cugat del Vallés, Spain Search for other works by this author on: Oxford Academic Google Scholar J.L. Arimany, J.L. Arimany Paediatrics and Search for other works by this author on: Oxford Academic Google Scholar M. Amagai, M. Amagai Department of Dermatology, Keio University School of Medicine, Tokyo, Japan Search for other works by this author on: Oxford Academic Google Scholar A. Camps A. Camps Departments of Dermatology Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 147, Issue 4, 1 October 2002, Pages 801–805, https://doi.org/10.1046/j.1365-2133.2002.04969.x Published: 01 October 2002 Article history Accepted: 06 April 2002 Published: 01 October 2002
MLN4924, an NAE inhibitor, suppresses AKT and mTOR signaling via upregulation of REDD1 in human myeloma cells
Authors: Yanyan Gu, Jonathan L. Kaufman, Leon Bernal, Claire Torre, Shannon M. Matulis, R. Donald Harvey, Jing Chen, Shi-Yong Sun, Lawrence H. Boise, Sagar Lonial
Journal: Blood (2014)
THE CAUSES OF SURGICAL FAILURE IN HYPERTHYROIDISM
Authors: J. EARL ELSE
Journal: JAMA (1922)

A review of the literature shows that from 65 to 75 per cent, of the patients operated on for exophthalmic goiter make a complete recovery. The majority of the remaining 25 to 35 per cent, are benefited; but some show no improvement, and death occurs in from 1 to 4 per cent. In the cardiovascular group of goiters, including the toxic adenomas, adenomatosis and compensatory hyperplasia, better results are obtained. During the last two and a half years, approximately 300 cases of goiter of various types have been studied. In this group have been several cases in which the patients had been previously operated on without complete relief. These cases were studied in conjunction with unoperated cases of similar types in order to determine, if possible, the causes of the incomplete results or failure. These causes have been classified thus: (1) errors in diagnosis; (2) overestimation of the patient's resistance;
Comparative effects of nicardipine, a new calcium antagonist, on size of myocardial infarction after coronary artery occlusion in dogs.
Authors: T Endo, J Nejima, S Fujita, K Kiuchi, N Iida, K Kikuchi, H Hayakawa, H Okumura
Journal: Circulation (1986)

To examine whether nicardipine, a dihydropyridine derivative, limits size of myocardial infarction, and to compare the protective effects of nicardipine administered before and early and late after coronary artery occlusion, 99mTc-labeled albumin microspheres were injected into the left atrium during 5 min temporary coronary artery occlusion to determine the extent of the hypoperfused zone (the area at risk). The coronary arteries were then reperfused for 45 min before 6 hr permanent coronary artery occlusion. Fifteen minutes before permanent occlusion, dogs were randomly assigned to a control group (n = 11), a pretreatment group (n = 9), which received at this point 10 micrograms/kg of nicardipine as a loading dose followed by a continuous infusion of 8 micrograms/kg/hr for 6 hr, an early treatment group (n = 9), in which nicardipine treatment was initiated 15 min after occlusion, or a late treatment group (n = 8), in which nicardipine administration was delayed for 3 hr. Six hours after coronary artery occlusion, the hearts were excised and the left ventricle of each was cut into 3 mm thick slices and stained with triphenyltetrazolium chloride. The extent of myocardial necrosis was measured by planimetry of the unstained areas. Thereafter, the same slices were autoradiographed and the extent of the hypoperfused zone was measured by planimetry of the "cold spot." The extent of the hypoperfused zone was identical among the four groups. In the control group, the ratio of the extent of myocardial necrosis to the extent of the hypoperfused zone was 95.8 +/- 3.8% (mean +/- SEM). However, it was significantly smaller in the pretreatment group (59.9 +/- 13.3%, p less than .05) and the early treatment group (49.0 +/- 10.6%, p less than .01) than in the control group. In the late treatment group, this value was not different from that in the control group (86.5 +/- 7.1%). There was a close inverse correlation between reduction of infarct size and the extent of the hypoperfused zone in the pretreatment and early treatment groups. Thus, nicardipine administered before or early after coronary artery occlusion limited infarct size by 37% to 49%, whereas when administration was delayed for 3 hr infarct size was not reduced. Furthermore, nicardipine had more striking effects on the ischemic myocardium of dogs with small hypoperfused zones than on that of dogs with large hypoperfused zones.
Bone Scan Demonstrating Metastasis to the Breast From an Ovarian Carcinoma and A Review of the Literature
Authors: Sukanta Barai, Rakesh Kumar, Achyut Kumar Haloi, None Dhanpati, Gurupada Banopadhyaya, Arun Malhotra
Journal: Clinical Nuclear Medicine (2004)

Breast metastasis from a primary ovarian neoplasm is very rare. We report a case of breast metastasis along with involvement of the liver, spleen, and pelvis from ovarian carcinoma in a 54-year-old woman demonstrated by whole-body bone scanning. Ovarian metastatic deposits frequently show calcification, and a Tc-99m MDP bone scan could be useful in determining the extent of calcified soft tissue metastatic spread in these patients. A review of the literature of breast metastases form ovarian carcinoma is discussed.
Oral Zidovudine, Continuous-Infusion Fluorouracil, and Oral Leucovorin Calcium: A Phase I Study
Authors: M. R. Posner, J. W. Darnowski, P. Calabresi, I. Brunetti, D. Corvese, G. Curt, F. J. Cummings, J. Clark, M. J. Browne, J. Beitz, A. B. Weitberg
Journal: JNCI Journal of the National Cancer Institute (1990)

A phase I clinical, pharmacologic, and biochemical evaluation of escalating oral zidovudine (AZT) given over 2 days with a fixed dose of continuous–infusion fluorouracil (800 mg/m 2 per day × 3 days) and oral leucovorin calcium was performed. Eighteen patients were treated with doses of AZT ranging from 1.0 to 9.0 g/m 2 per day. Nausea and vomiting were dose limiting, with a maximally tolerated dose of 7.5 g/m 2 per day. Rash and mucositis occurred but were not dose limiting. A dose–related increase in peak plasma levels of AZT was observed, and the alpha half–life of AZT in plasma (75 min) was unaffected by these high doses. At doses above 4.0 g/m 2 per day, trough levels significantly increased, perhaps reflecting prolonged absorption from the gut. No responses were observed; however, a significant increase in DNA single–strand breaks was observed in peripheral blood cells after a threshold dose of 4.0 g/m 2 per day, confirming a biological effect of AZT in this regimen. Further trials with an intravenous formulation capable of maintaining plasma levels and circumventing dose/limiting toxicity are warranted. [J Natl Cancer Inst 82:1710–1714, 1990]
Weight change with orally administered "antidiabetic" drugs
Authors: H. T. Ricketts
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
High-Normal Blood Pressure — More “High” Than “Normal”
Authors: Julio A. Panza
Journal: New England Journal of Medicine (2001)

On the basis of evidence from multiple clinical trials, it is recommended that antihypertensive therapy be instituted for patients with confirmed hypertension — that is, when the systolic blood pressure exceeds 140 mm Hg or the diastolic blood pressure exceeds 90 mm Hg.1 However, many patients who have a myocardial infarction, stroke, or other cardiovascular event have blood pressures below these thresholds. In fact, it is recognized that cardiovascular risk increases linearly at blood-pressure levels lower than those that usually trigger the use of antihypertensive therapy — specifically at a systolic pressure of 130 to 135 mm Hg and a . . .
THE IMMUNOCHEMISTRY OF TOXINS AND TOXOIDS
Authors: Louis Pillemer, Ruth G. Wittler, Jean I. Burrell, D. B. Grossberg
Journal: The Journal of Experimental Medicine (1948)

Methods for the purification and crystallization of tetanal toxin are described. The methods consist of the multiphase fractionation system involving methanol as the organic precipitating agent under controlled conditions of pH, ionic strength, protein concentration, and temperature. Crystalline tetanal toxin has an electrophoretic mobility of 2.8 x 10–5 in veronal buffer of 0.1 ionic strength at pH 8.6. The solubility of freshly prepared toxin is essentially constant. The isoelectric point is 5.1 ± 0.1. The crystalline toxin contains 1 per cent sulfur, traces of phosphorus, and gives the usual protein reactions. It does not contain carbohydrate. The crystalline toxin does not precipitate anti-Clostridium tetani rabbit serum. The final product contains between 3400 and 3600 Lf and about 6.6 x 107 M.L.D. per mg. N. Crystalline tetanal toxin is spontaneously converted to a flocculating atoxic dimer upon standing at 0°. This change is accompanied by the appearance of another molecular species as judged by constant solubility tests. Ultracentrifugal analysis of these fractions reveals that tetanal toxin has a sedimentation constant of 4.5 Svedberg units while the atoxic flocculating dimer sediments at 7 S.
Expert performance from the perspective of error identification
Authors: Vivekanand Tripathi, Namita Pande
Journal: British Journal of Sports Medicine (2010)

It is a fact that experts perform better than novices. Experts think faster and more accurately than novices. But what happens when a mistake occurs during the performance in a task. How experts and novices perform under such situation, when a mistake has already taken place, and how they find the solutions in an efficient manner? The present study investigates this issue that how experts are better in handling such situation where a mistake has taken place and they intend to rectify it. Error identification, resultant consequences, and rectification abilities, are the few dimensions on which the experts and novices have been assessed. Focused interview of two experts and one novice was done (after blind fold Rubik's cube solving), and the emerging themes were analysed. The present study reveals that while solving Rubik's cube, where a predesigned course of action (pre-programmed steps) was running, when there was any discrepancy found in the real intermediary step and pre-programmed intermediary step, then the experts and novices behave differently. While solving Rubik's cube, experts are able to identify the error earlier than the novices, and in comparison to novices experts handle such situation in a better manner. Experts stated that as soon as they identify an error they immediately start a process of rectification. While novices stated that only when they get stuck with cube, they realise that they did some mistake, and when they tried to rectify it they found it difficult. That makes experts effective, efficient and faster. It does not mean that experts are always correct or error free, they are also prone to mistakes, but most of the times their ‘rectification ability’ (due to more cumulative experience) helps them to control the situations. So if we include ‘error identification and rectification’ task in our training programmes than it will positively helps to improve the performance.
CLIMATOGRAPHY OF ARIZONA, WITH ESPECIAL REFERENCE TO THE CLIMATIC TREATMENT OF PULMONARY TUBERCULOSIS.
Authors: ROBERT W. CRAIG
Journal: JAMA (1902)

Of all diseases which have wrought devastation to the human race, there has never been a disease more deadly or more widely distributed than tuberculosis. Other communicable diseases have caused more dismay, and occasionally, for a short period, even greater destruction; but tuberculosis has been, and to a lesser degree continues to be, the most constant and virulent of all. It has been recently estimated that there are one million cases of active tuberculosis in the United States, and the latest authentic statistics show that 14 per cent. of the deaths recorded for ten years are due to some form of it. Climate, as affected by mere latitude, does not seem to have any influence on the disease. The death-rate from this cause is practically the same in New York, at a latitude of 44 degrees, and Manila, which is only 15 degrees from the equator. On the other hand,