tbuckley/cabot-search huggingface dataset:
The effect of flunarizine on intracellular calcium in isolated rat cardiomyocytes. A digital image processing study
Authors: H. GEERTS, R. NUYDENS, R. NUYENS, L. VER DONCK
Journal: Cardiovascular Research (1989)

Journal Article The effect of flunarizine on intracellular calcium in isolated rat cardiomyocytes. A digital image processing study Get access HUGO GEERTS, HUGO GEERTS From The Life Sciences Building, Janssen Research Foundation, Beerse, Belgium Address for correspondence and reprints: Dr Hugo Geerts, Laboratory of Biophysics, Janssen Research Foundation, Turnhoutseweg 30, B-2340 Beerse, Belgium. Search for other works by this author on: Oxford Academic PubMed Google Scholar RONY NUYDENS, RONY NUYDENS From The Life Sciences Building, Janssen Research Foundation, Beerse, Belgium Search for other works by this author on: Oxford Academic PubMed Google Scholar ROGER NUYENS, ROGER NUYENS From The Life Sciences Building, Janssen Research Foundation, Beerse, Belgium Search for other works by this author on: Oxford Academic PubMed Google Scholar LUC VER DONCK LUC VER DONCK From The Life Sciences Building, Janssen Research Foundation, Beerse, Belgium Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 23, Issue 9, September 1989, Pages 797–806, https://doi.org/10.1093/cvr/23.9.797 Published: 01 September 1989 Article history Accepted: 23 March 1989 Published: 01 September 1989
Put a social worker in charge
Authors: C. Douglas
Journal: BMJ (1994)

Winnie Mandela was one once. Nearer home, our own Mrs Bottomley too served her time as a social worker. For some years now I have worried a little about doctors who fall among politicians. Are there perhaps similar grounds for anxiety about social workers who do the same?

As with medicine, social work involves a professional exposure that might—in theory at least—make one a better politician. And to see distress and misery at first hand might engender a purer motivation for a career in politics than, say, merchant banking, public relations, being married to a millionaire, or inheriting the family constituency.

Or perhaps not. But I would never even have considered the question had I not recently come cross a dusty little book published in 1920 …
342 Methylthioadenosin phosphorylase (MTAP) expression is frequently lost in hepatocellular carcinoma
Authors: C. Hellerbrand, M. Schuierer, M. Muhlbauer, S. Wallner, I. Behrmann, F. Bataille, J. Schölmerich, A.K. Bosserhoff
Journal: Journal of Hepatology (2004)
774. Studies on the Intracellular Release of Genetic Drugs from Pharmaceutical Carriers
Authors: Bart Lucas, Katrien Remaut, Stefaan C. De Smedt, Roosmarijn Vandenbroucke, Joseph Demeester
Journal: Molecular Therapy (2005)

To reveal how DNA/cationic carrier complexes physicochemically behave in cells, dual color fluorescence fluctuation spectroscopy (dual color FFS) is a promising tool. FFS monitors the fluorescence fluctuations caused by the diffusion of fluorescently labeled molecules through the excitation volume of a microscope. Dual color FFS answers the question whether the DNA and the cationic carrier move together (i.e. when they are associated) or separately (i.e. when they are dissociated) through the excitation volume.
Health problems due to pesticides may be underestimated
Authors: Nick Smallwood
Journal: BMJ (2005)

The risks associated with exposure to agricultural pesticides has been underestimated by the Department for Environment, Food, and Rural Affairs, a new report from the UK Royal Commission on Environmental Pollution warns. And the report says that further investigation is needed to assess the impact of pesticides on human health.

Reports to the Commission from the public have raised concerns that unsafe pesticide concentrations in crop spraying are causing a wide range of health problems. …
Phosphoribosyltransferase (PRT) and Adenine PRT (A-PRT) Deficiency States in Man—New Inborn Errors of Purine Metabolism
Authors: JAMES B. WYNGAARDEN
Journal: Annals of Internal Medicine (1969)

Editorial Notes1 January 1969Phosphoribosyltransferase (PRT) and Adenine PRT (A-PRT) Deficiency States in Man—New Inborn Errors of Purine MetabolismJAMES B. WYNGAARDEN, M.D.JAMES B. WYNGAARDEN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-70-1-229 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptElsewhere in this issue, Kelley and associates (1) have summarized present knowledge of one recently recognized subtype of primary gout, a variety attributable to a marked deficiency of activity of hypoxanthine-guanine phosphoribosyltransferase (PRT). This particular type of gout, which characteristically presents before age 30, is marked by hyperuricemia greater than 9 mg/100 ml, urinary uric acid excretion values above 1,000 mg/day, and in some subjects by neurological abnormalities, megaloblastic marrow changes, or both. The diagnosis is established by assay of PRT activity of erythrocytes.A total absence of demonstrable activity of this enzyme has been associated with a pediatric syndrome...References1. KELLEYGREENEROSENBLOOMHENDERSONSEEGMILLER WNMLFMJFJE: Hypoxanthine—guanine phosphoribosyltransferase in gout. Ann. Intern. Med. 70: 155, 1969. LinkGoogle Scholar2. LESCHNYHAN MWL: A familial disorder of uric acid metabolism and central nervous system function. Amer. J. Med. 35: 561, 1964. CrossrefGoogle Scholar3. BRADFORDKRAKOFFLEEPERBALIS MJIHRME: Study of purine metabolism in a xanthinuric female. J. Clin. Invest. 47: 1325, 1968. CrossrefMedlineGoogle Scholar4. KELLEYLEVYROSENBLOOMHENDERSONSEEGMILLER WNRIFMJFJE: Adenine phosphoribosyltransferase deficiency: a previously undescribed genetic defect in man. J. Clin. Invest. 47: 2281, 1968. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Duke University Medical Center Durham, N. C. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1969Volume 70, Issue 1Page: 229-230KeywordsAdenineBone marrowEnzymesExcretionGoutPurine metabolismUric acid Issue Published: 1 January 1969 PDF DownloadLoading ...
PAR1 contributes to influenza A virus pathogenicity in mice
Authors: Khaled Khoufache, Fatma Berri, Wolfgang Nacken, Annette B. Vogel, Marie Delenne, Eric Camerer, Shaun R. Coughlin, Peter Carmeliet, Bruno Lina, Guus F. Rimmelzwaan, Oliver Planz, Stephan Ludwig, Béatrice Riteau
Journal: Journal of Clinical Investigation (2012)

Influenza causes substantial morbidity and mortality, and highly pathogenic and drug-resistant strains are likely to emerge in the future. Protease-activated receptor 1 (PAR1) is a thrombin-activated receptor that contributes to inflammatory responses at mucosal surfaces. The role of PAR1 in pathogenesis of virus infections is unknown. Here, we demonstrate that PAR1 contributed to the deleterious inflammatory response after influenza virus infection in mice. Activating PAR1 by administering the agonist TFLLR-NH2 decreased survival and increased lung inflammation after influenza infection. Importantly, both administration of a PAR1 antagonist and PAR1 deficiency protected mice from infection with influenza A viruses (IAVs). Treatment with the PAR1 agonist did not alter survival of mice deficient in plasminogen (PLG), which suggests that PLG permits and/or interacts with a PAR1 function in this model. PAR1 antagonists are in human trials for other indications. Our findings suggest that PAR1 antagonism might be explored as a treatment for influenza, including that caused by highly pathogenic H5N1 and oseltamivir-resistant H1N1 viruses.
THE PRACTICAL APPLICATION OF EXCRETORY (INTRAVENOUS) UROGRAPHY
Authors: WILLIAM F. BRAASCH
Journal: JAMA (1933)

The name of this new method of urographic visualization, which has become one of the most valuable aids in clinical diagnosis, deserves consideration. Since its inception it has been most often referred to by the term "intravenous urography," which was adopted to distinguish it from "cystoscopic" or "retrograde urography." It has also been referred to as "descending" or "excretion urography" by European observers. "Excretory urography" would seem the logical term, since it is physiologically descriptive and, in view of recent and portending advances in oral administration, would be quite acceptable. The members of the medical profession have been inexcusably slow in availing themselves of the opportunities offered by excretory urography in the diagnosis of abdominal lesions. Judging from the frequent requests made by patients for excretory urography rather than cystoscopy, it might be inferred that laymen are more familiar with the method than some physicians. It should and probably will
Skin testing in hospital.
Authors: R M Du Bois, C A Poulton, Y Smithers, D T Hughes
Journal: BMJ (1977)

with tritiated thymidine.Thrombosed vessels were occasionally seen in the bases of the oesopha- geal ulcers, with gross epithelial hyperplasia and numerous mitotic figures which were distin- guishable from carcinomas only by the absence of muscular invasion of the disorganised epithelial overgrowth.Most of these lesions cleared with
Sustained Remission of Cushing's Disease with Mitotane and Pituitary Irradiation
Authors: DAVID E. SCHTEINGART
Journal: Annals of Internal Medicine (1980)

Low doses of mitotane were given orally to 36 patients with Cushing's disease, concurrently with or after pituitary cobalt irradiation. Clinical and biochemical remission occurred in 29. The response to treatment occurred early in 17 patients and late in 12. The different pattern of response to mitotane was not related to the dose given or to its serum level. Early biochemical indicators of adrenal suppression with mitotane were a sharp decrease in adrenal response to the infusion of ACTH and in plasma levels of dehydroepiandrosterone sulfate. Although mitotane was given together with pituitary irradiation, initial remission was due mainly to the adrenal effect of mitotane. Plasma ACTH levels were still elevated when cortisol had returned to normal. In seventeen of the 29 patients who responded to treatment drug therapy has been discontinued, and they remain in remission of Cushing's syndrome. Side-effects have been dose dependent, with anorexia, nausea, decreased memory, and gynecomastia in men being the commonest.
Immune tolerance to autoantibody-derived peptides delays development of autoimmunity in murine lupus.
Authors: R R Singh, F M Ebling, E E Sercarz, B H Hahn
Journal: Journal of Clinical Investigation (1995)

Mechanisms that initiate and maintain autoantibody (autoAb) production in individuals with autoimmune diseases like SLE are poorly understood. Inadequate suppression of autoreactive T cells and/or unusual activation of T and B cells may underlie the persistence of pathogenic autoAbs in lupus. Here, we examine the possibility that in mice with lupus, autoAb molecules may be upregulating their own production by activating self-reactive T cells via their own processed peptides; downregulation of this circuit may decrease autoAb production and delay the development of lupus. We found that before the onset of clinical disease, lupus-prone (NZB/NZW) F1 [BWF1] (but not MHC-matched nonautoimmune mice) developed spontaneous T cell autoimmunity to peptides from variable regions of heavy chains (VH) of syngeneic anti-DNA mAbs but not to peptides from the VH region of an mAb to an exogenous antigen. Tolerizing young BWF1 mice with intravenous injections of autoAb-derived determinants substantially delayed development of anti-DNA antibodies and nephritis and prolonged survival. Thus, in such an autoAb-mediated disease, the presence of autoreactive T cells against VH region determinants of autoAbs may represent an important mechanism involved in the regulation of autoimmunity. Our findings show that tolerizing such autoreactive T cells can postpone the development of an autoimmune disease like SLE.
The “Bat Sign” of Pectoral Rhabdomyolysis
Authors: Soledad Armijo, Mónica Peña, Felipe Bustos, Bárbara Morales
Journal: Clinical Nuclear Medicine (2009)

A 22-year-old man with foot pain was referred for evaluation of sesamoiditis. A Tc-99m methylene-diphosphonate bone scan was performed which revealed increased radiopharmaceutical uptake in the big toes, but also showed curious abnormal thoracic activity. Normal activity at sternoclavicular joints and sternum mimics ears, head and body of a bat, and the pectorals mimic the wings. The patient mentioned that he had started lifting weights a few days earlier. Clinical and echographic evaluations were diagnostic of pectoral inflammation suggesting rhabdomyolysis.
EFFECTS OF CYTOCHALASIN B ON EPIDERMAL CELLS IN VITRO
Authors: HILARY CONSTABLE, C. N. D. CRUICKSHANK, PATRICIA R. MANN
Journal: British Journal of Dermatology (1972)

Summary.— Effects of cytochalasin B have been studied on organ cultures and dispersed cell cultures of adult guinea-pig ear skin, using electron microscopy and time-lapse cinephotomicrography. Cytochalasin B failed to inhibit epiboly at 1 ug/ml, caused slight inhibition at 2 ug/ml and total inhibition at 5 ug/ml. These concentrations did not appear to affect ruffling of membranes or internal cell movements. Some effect was demonstrated at 20 ug/ml. These concentrations, however, caused a general toxic effect on the cells. Ultrastructurally, there was possibly some reduction in the microfilament system, but this was far from dramatic. Abnormalities caused were increased numbers of Lysosomes and dilation of the endoplasmic reticulum.
Tob is a potential marker gene for the basal layer of the epidermis and is stably expressed in human primary keratinocytes
Authors: G.T. Park, E.Y. Seo, K.M. Lee, D.Y. Lee, J.M. Yang
Journal: British Journal of Dermatology (2005)

Journal Article Tob is a potential marker gene for the basal layer of the epidermis and is stably expressed in human primary keratinocytes Get access G.T. Park, G.T. Park Clinical Research Centre, Samsung Biomedical Research Institute, Seoul 135‐710, KoreaDepartment of Dermatology, Sungkyunkwan University School of Medicine, Samsung Medical Centre, Seoul 135‐710, Korea Search for other works by this author on: Oxford Academic Google Scholar E.Y. Seo, E.Y. Seo Clinical Research Centre, Samsung Biomedical Research Institute, Seoul 135‐710, Korea Search for other works by this author on: Oxford Academic Google Scholar K.M. Lee, K.M. Lee Clinical Research Centre, Samsung Biomedical Research Institute, Seoul 135‐710, Korea Search for other works by this author on: Oxford Academic Google Scholar D.Y. Lee, D.Y. Lee Clinical Research Centre, Samsung Biomedical Research Institute, Seoul 135‐710, KoreaDepartment of Dermatology, Sungkyunkwan University School of Medicine, Samsung Medical Centre, Seoul 135‐710, Korea Search for other works by this author on: Oxford Academic Google Scholar J.M. Yang J.M. Yang Clinical Research Centre, Samsung Biomedical Research Institute, Seoul 135‐710, KoreaDepartment of Dermatology, Sungkyunkwan University School of Medicine, Samsung Medical Centre, Seoul 135‐710, Korea Jun‐Mo Yang. E‐mail: jmyang@smc.samsung.co.kr Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 154, Issue 3, 1 March 2006, Pages 411–418, https://doi.org/10.1111/j.1365-2133.2005.07037.x Published: 01 March 2006 Article history Accepted: 24 June 2005 Published: 01 March 2006
Captopril Overdose and Hypotension
Authors: Franklin D. Jones
Journal: JAMA (1988)

<h3>To the Editor.—</h3> The article by Augenstein et al<sup>1</sup>raises a question about the role of alprazolam in producing hypotension. Their review of prior cases of overdose seems to reveal a more benign course than that of their patient; for example, a 3-year-old child who ingested eight to ten 25-mg captopril tablets surely ingested, on the basis of body size, a proportionally greater amount than the 20 to 30 tablets taken by the "obese" 33-year-old patient yet the child was essentially asymptomatic. Similarly, the two French patients were not even seen until a day after overdosing, and one had transient orthostatic hypotension. The authors' patient, however, had an initial and two later episodes of hypotension at 18.5 and 24.5 hours after ingestion, all requiring vigorous intervention with fluids and dopamine. The authors assume that the hypotension was due to the captopril since benzodiazepines rarely cause hypotension in overdosage. However,
Cadillacs and garbage trucks.
Authors: G Dunea
Journal: BMJ (1980)

The luxuriant growth of America's not-for-profit hospital industry would excite less controversy if it were not so heavily subsidised by public funds?either directly or through advan tageous reimbursement formulae and favourable tax rules. Last June even the ailing Mrs O'Leary (an imaginary old lady who lives only in the pages of the New England Journal of Medicine) had no difficulty in grasping the immense possibilities of what in essence is an investor's dream: borrowing money interest free, and then paying no taxes on subsequent profits.1 This the voluntary hospitals apparently achieve, on the one hand, by having Medicare and insurance carriers reimburse them for interest paid on loans relating to patient care activities (including mortgages), as well as for the wear and tear of their buildings and equipment (depreciation); and, on the other hand, by being exempt from paying taxes by virtue of their not-for-profit status. So that under these arrangements a hospital could borrow, build, borrow some more, and eventually eat up Chicago, or Philadelphia, or, for that matter, any large city in need of a vigorous slum clearance programme.1 But even the world-wise Mrs O'Leary would have had trouble reinvesting the profits without timely help from one of the newspaper expos?s that periodically enliven the dreary monotony of our virtuous city.2 Mrs O'Leary has now learnt how a not-for-profit hospital collecting millions of dollars from Medicare can operate a for profit restaurant owned by the hospital's executive director, or lease laboratory equipment from a company belonging to two of its doctors and its former executive director; how hospitals may have management contracts with firms controlled by some of their directors; how hospital trustees may own companies providing legal advice, hospital food, laundry and uniform cleaning, electrical work, lease of medical equipment, insurance, and investment services; how a voluntary hospital director may use not-for-profit hospital funds to pay the salaries of doctors working in his private clinic as well as his own salary of $250 000; and how government funds may be used to lobby against the Government's cost containment Bill. Of particular interest to Mrs O'Leary has been the little hospital that invested Medicare funds to operate a health club for top hospital administrators and select businessmen, so that at all times of the day sporting gentlemen with small bags would be seen rushing through the back door to exercise in an area ostensibly built for patient rehabilitation. This hospital, incidentally, also paid hundreds of thousands of dollars rent to secret land trusts whose beneficiaries were the owners and trustees of the hospital; used $185 000 to purchase the goodwill of a clinic belonging to the trustees; and spent large sums for public relations and for leasing a fleet of Cadillacs for the directors and administrators.2 An official investigation, now under way, should offer even better ideas for the investment-hungry old lady.
Practical recommendations for the use of ACE inhibitors, beta‐blockers and spironolactone in heart failure: putting guidelines into practice
Authors: McMurray John, Cohen‐Solal Alain, Dietz Rainer, Eichhorn Eric, Erhardt Leif, Hobbs Richard, Maggioni Aldo, Pina Ileana, Soler‐Soler Jordi, Swedberg Karl
Journal: European Journal of Heart Failure (2001)
Mammography Before Age 50 Years?
Authors: John C. Bailar
Journal: JAMA (1988)

Considerable agreement exists about mammography. Virtually all experts conclude that an asymptomatic woman who is at least 50 years old will benefit from regular breast cancer screening by a combination of mammography and careful physical examination. Most agree, also, that women who have genuine signs or symptoms suggestive of a malignant lesion are candidates for mammography, regardless of their age, when it is clear that the examination is needed to determine the next steps in the diagnostic studies. This use of mammography, as an aid to diagnosis rather than for screening, will generally be appropriate when the examination will assist in determining whether, where, and how to perform a biopsy. While agreement exists for this population of women, for those younger than 40 years of age, the arguments for a "baseline" examination are incomplete and unconvincing. No good evidence exists showing that the availability of baseline films affects the later
Cervical Cancer and the Elusive Male Factor
Authors: Hans-Olov Adami, Dimitrios Trichopoulos
Journal: New England Journal of Medicine (2002)

Male circumcision is probably one of the oldest surgical procedures and is still the most common. Globally, about one man in four is likely to undergo circumcision for various reasons.1 In the United States, an estimated 80 percent of all newborn boys were circumcised in the 1970s. These rates have subsequently decreased, however, as a result of several policy statements issued by the American Academy of Pediatrics. According to the most recent of these documents, the medical benefits are “not sufficient to recommend routine neonatal circumcision.”2 Notwithstanding this balanced statement, it is generally accepted that circumcision may reduce the prevalence . . .
Autoimmune thyroid disease and pregnancy.
Authors: A M McGregor, R Hall, C Richards
Journal: BMJ (1984)

The cholinergic drug pilocarpine may cause sweating and salivation, nausea, vomiting and diarrhoea, and bronchospasm.Finally, any mydriatic at all used by a casualty officer in an unconscious patient will produce a severe systemic adrenergic reaction-in the neurologist or neurosurgeon who receives the patient.The casualty officer should never forget that the size and reactions of the pupils are important in the manage- ment of patients in coma, with head injuries, or with many other neurological diseases.
Where Rides Psychiatry?
Authors: Nathan Masor
Journal: JAMA (1964)

<h3>To the Editor:—</h3> The presentation of two separate and diametrically opposed points of view in the same issue ofThe Journalemphasizes the confusion characteristic of the present status of psychiatry. I quite agree with the communication, "And Madly Ride," (editorial, March 21, 1964 [<b>187</b>:946]), especially the statement: "Psychiatry and psychoanalysis today have not lived up to their well-advertised and hoped-for promise." I believe that psychoanalysis is a cult, not a science, whose high priests genuflect at the altar of the phallic symbol. The two main analytic approaches—the Freudian (with emphasis on downward gazing at the genitals) and the Jungian (fixating upwards toward heaven)—should be more appropriately assayed as vehicles for amusement rather than serious therapy. Many physicians, in agreement with this point of view, hold that only the volubility of psychiatry's orthodox adherents, amidst an ecstasy of learned ignorance, is responsible for the aura of respectability that dignifies
Type 2 Arteriovenous Malformation of the Sigmoid Colon with Unusual Angiographic and Characteristic Histologic Appearances
Authors: S.G. Kulkarni, P. S. Dhawan, S. S. Shah, R. Rananavare, I. M. Vora, K. Shankaran, R. H. Kalro
Journal: Endoscopy (1998)