tbuckley/cabot-search huggingface dataset:
Synchronization of repolarization by mechano-electrical coupling in the porcine heart
Authors: Tobias Opthof, Veronique M.F. Meijborg, Charly N.W. Belterman, Ruben Coronel
Journal: Cardiovascular Research (2015)

The aim of this study was to evaluate the effect of increase in left ventricular (LV) pressure on repolarization and activation-recovery intervals.Six pig hearts were Langendorff-perfused. A compliant liquid-filled balloon, connected with a pressure transducer, inserted through the mitral orifice, could be filled until the required LV systolic pressure was obtained. A grid of 121 electrodes (11 × 11; 5 mm interelectrode distance) was sutured on the LV free wall. Ventricular pacing at 600 ms and at 400 or 450 ms was either performed from the LV wall or from the ventricular septum. Under all these four conditions, the pressure wave occurred at the same moment relative to the onset of the QRS complex. Consequently, the time relation between local repolarization and the pressure wave differed between the various pacing sites. Repolarization times (RTs) at a cycle length (CL) of 600 ms were prolonged by increased pressure. With stimulation from the LV, when the pressure wave coincides with the action potentials (APs) late in their phase (sites with relatively early repolarization), an increase in pressure from 0 to 100 mmHg delayed repolarization more than with stimulation from the septum, when the pressure wave occurs at a relatively earlier phase of the AP (sites with relatively late repolarization). At pacing at CL 400/450 ms, an increase in pressure caused RT prolongation at the LV free wall during LV stimulation, but less RT prolongation or even shortening during septal stimulation.The effect of increased LV pressure is synchronization of repolarization.
GRANULOMA ANNULARE.
Authors: E. L. RHODES, D. M. HILL, A. C. AMES, C. A. TOURLE, C. G. TAYLOR
Journal: British Journal of Dermatology (1966)

Journal Article GRANULOMA ANNULARE: PrednisoneGlycosuriaTests in a Non‐Diabetic Group Get access E. L. RHODES, M.R.C.P., D.C.H, E. L. RHODES, M.R.C.P., D.C.H Senior Registrar, Department of Dermatology Search for other works by this author on: Oxford Academic Google Scholar D. M. HILL, M.A., B.M., M.R.C.P., D. M. HILL, M.A., B.M., M.R.C.P. Lecturer in Medicine Search for other works by this author on: Oxford Academic Google Scholar A. C. AMES, M.B., B.S., B.Sc., A. C. AMES, M.B., B.S., B.Sc. Senior Registrar, Department of Chemical Pathology Search for other works by this author on: Oxford Academic Google Scholar C. A. TOURLE, M.B., B.S., C. A. TOURLE, M.B., B.S. Lately House Physician, Department of Dermatology Search for other works by this author on: Oxford Academic Google Scholar C. G. TAYLOR, M.B., B.S. C. G. TAYLOR, M.B., B.S. House Physician, Department of Dermatology. King's College Hospital and Medical School, London Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 78, Issue 10, 1 October 1966, Pages 532–535, https://doi.org/10.1111/j.1365-2133.1966.tb12142.x Published: 01 October 1966
Myeloid cell subsets dynamic during progression of mouse collagen-induced arthritis
Authors: J. Presumey, C. Jorgensen, G. Courties, F. Apparailly
Journal: Annals of the Rheumatic Diseases (2011)

<h3>Background and objectives</h3> Circulating monocytes consist at least of two main subsets of immune cells arising from a common progenitor in the bone marrow that can give rise to macrophages and dendritic cells upon entry into tissues.1 Consistent with the recent description of three subpopulations of monocytes, previous studies performed in rheumatoid arthritis (RA) do not allow to fully understand their respective functions since generally only the classical CD14 monocytes are considered.2 Interestingly, their mouse homologues are well defined in experimental models of autoimmunity, and a splenic 'reservoir' of true monocytes able to migrate into injured tissues to regulate inflammation has also been recently described.3 Nevertheless, the three monocyte populations are not described in mouse models of arthritis. The present study aimed at fully characterising monocyte subsets and monocyte-derived cells during the development of collagen-induced arthritis (CIA) to unravel their respective role in the RA pathogenesis. <h3>Materials and methods</h3> Using flow cytometric immunophenotyping, the authors have analysed the expression of several specific myeloid cell markers, CD11b, Ly6C, Ly6G, CD43, CD115, F4/80, CD11c, PDCA1, CMHII in the mouse CIA model. Frequencies of the various cell subpopulations have been assessed in the blood, spleen, draining lymph nodes and inflamed joints at different stages of the disease, and compared to naïve mouse samples. <h3>Results</h3> In the circulation, the Ly6C<sup>low</sup> monocyte frequency drops after the boost (D21), and is followed by a sequential raise of Ly6C<sup>int</sup> and Ly6C<sup>high</sup> monocytes at later time points of disease. A Ly6C<sup>high</sup> monocytosis is observed in the spleen from D21. In inflamed joints, the number of neutrophils increased from ∼30% up to ∼60% compared with steady state and represent the main source for local tumour necrosis factor α (TNFα) production. Surprisingly, monocytes/macrophages are found in significant amount within steady state joints (∼2%) and their number increased during CIA (∼5% of total cells). Finally, the subpopulation of Ly6C<sup>low</sup> monocytes/macrophages observed in steady state conditions does not fluctuate within CIA joints while the Ly6C<sup>int/high</sup> monocytes/macrophages increase overtime and produce high levels of TNFα. <h3>Conclusion</h3> Overall, this data show that all three monocyte subsets are not only present within blood and lymphoid organs as previously described, but also within joints, in both steady state and pathological conditions, and their frequencies within these tissues fluctuates in a dynamic manner.
CDH13 Genotype–Dependent Association of High–Molecular Weight Adiponectin With All-Cause Mortality: The J-SHIPP Study
Authors: Eri Uetani, Yasuharu Tabara, Ryuichi Kawamoto, Hiroshi Onuma, Katsuhiko Kohara, Haruhiko Osawa, Tetsuro Miki
Journal: Diabetes Care (2013)

Despite its anti-inflammatory and antiatherogenic effects, adiponectin is potentially associated with adverse clinical outcomes, such as all-cause mortality. As plasma adiponectin levels are strongly influenced by single nucleotide polymorphisms in the gene encoding T-cadherin (CDH13), we conducted a longitudinal study to investigate the possible link between the CDH13 genotype, plasma adiponectin levels, and all-cause mortality.This longitudinal study evaluated 2,020 Japanese subjects. Baseline clinical parameters were obtained from subjects' personal health records as evaluated at annual medical check-ups. Plasma high-molecular weight adiponectin (HMWA) levels were measured by an ELISA assay, and genotyping was performed by a TaqMan probe assay.Mean follow-up duration was 6.5 years. Kaplan-Meier analysis showed that HMWA levels were positively associated with mortality (P < 0.001). HMWA levels were associated with older age, lower body weight, lower plasma triglyceride and glucose levels, and higher plasma HDL cholesterol. However, the Cox regression analysis showed that the positive association between HMWA and all-cause mortality was independent of these covariates (hazard ratio [HR] 1.92, P = 0.006). The CDH13 rs4783244 genotype was strongly associated with baseline HMWA levels (per-allele effect size 1.65 μg/mL, P < 0.001). In a separate analysis by the CDH13 genotype, the HR for all-cause mortality was linearly increased with the number of G alleles (P value for HMWA-CDH13 genotype interaction = 0.023).Higher plasma HMWA level was an independent prognostic factor for all-cause mortality in a general population. The CDH13 genotype may be a factor that affects not only the plasma level of HMWA but also the prognostic significance of HMWA.
Treatment for delayed stress response
Authors: May Annexton
Journal: JAMA (1978)

A husband dies unexpectedly. His wife makes funeral arrangements, receives comfort from family and friends, and apparently accepts the tragedy. Then one day she realizes she feels emotionally numb, the shock sets in, and she can no longer cope. A man suffers serious injuries when his car collides with another. He recuperates from his physical injuries after extended hospitalization. Then the psychological trauma strikes; coping is impossible. In both cases, the emotional stress response is similar. Patients with such stress response syndromes now are being treated with a modified, brief psychotherapy approach by Mardi Horowitz, MD, and associates at the Langley Porter Institute of the University of California at San Francisco. The goal is to restore psychosocial homeostasis with (if possible) only 12 hours of therapy. In each case the patient is assigned to an interviewer and a therapist. Interviews are audiotaped and videotaped to provide the therapist with insight
A POSSIBLE SOURCE OF HAND CONTAMINATION
Authors: Francis Ramaley
Journal: JAMA (1924)

<h3>To the Editor:</h3> —May I suggest, as one interested in hygiene, that you consider the possible advantages in having fixtures in toilet rooms so made as to allow of their operation by the foot instead of the hand? The possibilities of getting infectious material on the hand and then on a fixture-handle are so obvious that it would seem that manufacturers might be interested in making their fixtures more sanitary if the subject could be called to their attention. <h3>Disease Migration.</h3> —All human diseases that were capable of migrating from their original habitat have done so. Those that have not spread have been tied to definite factors, such as special intermediate hosts or vectors.—Theobald Smith.
Autoimmune Hemolytic Anemia with Reticulocytopenia and Erythroid Marrow
Authors: C L Conley, S M Lippman, P M Ness, L D Petz, D R Branch, M T Gallagher
Journal: New England Journal of Medicine (1982)

IN the course of a hemolytic disorder, episodes may occur during which reticulocytes virtually disappear from the blood, with the result that uncompensated destruction of red cells leads to progressively severe anemia. "Aplastic crises" were first described in hereditary spherocytosis1 and have been observed in many other hemolytic states, including autoimmune hemolytic anemia (AIHA).2 3 4 5 6 7 Often attributable to intercurrent infection, the episodes are usually brief and characterized by transient absence of red-cell precursors from the marrow. In some cases of AIHA, there are prolonged periods of reticulocytopenia, at times accompanied by leukopenia, thrombocytopenia, and hypoplastic marrow.8 9 10 In other cases, severe reticulocytopenia . . .
Serum Osteopontin Levels — Is It Time to Screen Asbestos-Exposed Workers for Pleural Mesothelioma?
Authors: Mark R. Cullen
Journal: New England Journal of Medicine (2005)

In this issue of the Journal, Pass et al.1 remind us yet again that the fallout from the once uncontrolled use of asbestos will remain with us for years to come. Thankfully, primary prevention of mesothelioma and the far more prevalent consequence of exposure to asbestos — carcinoma of the lung — has been aggressively pursued to varying degrees in all developed countries: most potential sources of human exposure have now been removed or encapsulated, and the introduction of additional asbestos severely curtailed or banned outright. Unfortunately, among the millions exposed occupationally in the past who remain at high risk . . .
Histopathological heterogeneity of neuropathy in insulin-dependent and non-insulin-dependent diabetes, and demonstration of axo-glial dysjunction in human diabetic neuropathy.
Authors: A A Sima, V Nathaniel, V Bril, T A McEwen, D A Greene
Journal: Journal of Clinical Investigation (1988)

Altered sorbitol and myo-inositol metabolism, (Na,K)-ATPase function, electrochemical sodium gradients, axonal swelling, and distortion and disruption of the node of Ranvier ("axo-glial dysjunction") directly implicate hyperglycemia in the pathogenesis of neuropathy in diabetic rats, but the relevance of this sequence to clinical neuropathy in heterogeneous groups of diabetic patients remains to be established. Fascicular sural nerve morphometry in 11 patients with neuropathy complicating insulin-dependent diabetes revealed a pattern of interrelated structural changes strikingly similar to that of the diabetic rat when compared to age-matched controls. 17 older non-insulin-dependent diabetic patients with comparable duration and severity of hyperglycemia and severity of neuropathy, displayed similar nerve fiber loss, paranodal demyelination, paranodal remyelination and segmental demyelination compared to age-matched controls, but axo-glial dysjunction was replaced by Wallerian degeneration as the primary manifestation of fiber damage, and fiber loss occurred in a spatial pattern consistent with an ischemic component. The mechanistic model developed from the diabetic rat does indeed appear to apply to human diabetic neuropathy, but superimposed hormonal, metabolic, vascular, and/or age-related effects alter the morphologic expression of the neuropathy in non-insulin dependent diabetes.
THE VITAMIN B12 LEVEL IN PSORIATIC SKIN AND SERUM
Authors: L. STANKLER
Journal: British Journal of Dermatology (1969)

Journal Article THE VITAMIN B12 LEVEL IN PSORIATIC SKIN AND SERUM Get access L. STANKLER L. STANKLER Department of Dermatology, Royal Infirmary, Aberdeen Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 81, Issue 12, 1 December 1969, Pages 911–918, https://doi.org/10.1111/j.1365-2133.1969.tb15973.x Published: 01 December 1969 Article history Accepted: 14 March 1969 Published: 01 December 1969
Secondary Prevention and Mortality in Peripheral Artery Disease
Authors: Reena L. Pande, Todd S. Perlstein, Joshua A. Beckman, Mark A. Creager
Journal: Circulation (2011)

Background— Whether individuals with peripheral artery disease (PAD) identified by screening ankle-brachial index benefit from preventive therapies to reduce cardiovascular risk is unknown. We aimed to determine the number of US adults with PAD who are not receiving preventive therapies and whether treatment is associated with reduced mortality in PAD subjects without known cardiovascular disease. Methods and Results— We analyzed data from the National Health and Nutrition Examination Survey (NHANES) 1999 to 2004 with mortality follow-up through December 31, 2006. We defined PAD as an ankle-brachial index ≤0.90. Of 7458 eligible participants ≥40 years, weighted PAD prevalence was 5.9±0.3% (mean±SE), corresponding to ≈7.1 million US adults with PAD. Statin use was reported in only 30.5±2.5%, angiotensin-converting enzyme inhibitor/angiotensin receptor blocker use in 24.9±1.9%, and aspirin use in 35.8±2.9%, corresponding to 5.0 million adults with PAD not taking statins, 5.4 million not taking angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, and 4.5 million not receiving aspirin. After adjustment for age, sex, and race/ethnicity, PAD was associated with all-cause mortality (hazard ratio, 2.4; 95% confidence interval, 1.9 to 2.9; P &lt;0.0001). Even after exclusion of individuals with known cardiovascular disease, subjects with PAD had higher mortality rates (16.1±2.1%) than subjects without PAD or cardiovascular disease (4.1±0.3%), with an adjusted hazard ratio of 1.9 (95% confidence interval, 1.3 to 2.8; P =0.001). Among PAD subjects without cardiovascular disease, use of multiple preventive therapies was associated with 65% lower all-cause mortality (hazard ratio, 0.35; 95% confidence interval, 0.20 to 0.86; P =0.02). Conclusions— Millions of US adults with PAD are not receiving secondary prevention therapies. Treatment with multiple therapies is associated with reduced all-cause mortality.
THE DELAY OF OLD AGE AND THE ALLEVIATION OF SENILITY.ORATION ON MEDICINE AT THE FIFTY-SIXTH ANNUAL SESSION OF THE AMERICAN MEDICAL ASSOCIATION AT PORTLAND, OREGON, JULY 11-14, 1905.
Authors: CHARLES G. STOCKTON
Journal: JAMA (1905)

In 1805, Lewis and Clark, typical and celebrated among American explorers, turned their faces toward the furthest west and disclosed in a single expedition the possibilities of the continent and the mysteries of the great undiscovered. Their feat was in principle but a repetition of the undertakings of Columbus, De Soto and La Salle, of Daniel Boone and the numberless pioneers who so quickly, almost suddenly, transformed America from a desolate wilderness into the puissant commonwealth of to-day. In each we may discern a discontent with the established order and environment of his heritage; an inspiration to find in newness a satisfaction which the settled regions, settled habits of thought, settled manners of life failed to provide him at home. The word "settled" is significant. Our race is without rest until it settles things; and with this there stalks a poignant impatience with the things that are settled. The new,
Clinical trial of vaccine for type B hepatitis to begin next month
Authors: Phil Gunby
Journal: JAMA (1979)

The first large-scale American trial of a vaccine for a sexually transmitted disease begins next month. The disease is type B hepatitis. The trial with the new vaccine will be among homosexual men. The go-ahead was given because of results from a just-completed study. This study, conducted in five large cities, indicates that sexually transmitted hepatitis B infections are far more common among homosexual men than has been suspected. Researchers found antibody titer evidence of previous hepatitis B infection in at least 45% of the homosexual men studied. In the San Francisco area, the rate was 58%. Based on those and other findings, the immunization trial will begin in April in at least five clinics. Two of these clinics, in Chicago and Los Angeles, are operated privately by homosexual groups to serve homosexual patients. The other three, in Denver, St Louis, and San Francisco, are public health clinics that serve
Abstract P3-10-14: The Prognostic Significance of mib-1 (according to St Gallen Criteria) in Patients (pts) with Early Invasive Breast Cancer (EIBC) and Its Relationship with other Biologic Parameters in a Monoinstitutional Series
Authors: A Ferro, A Caldara, C Eccher, R Triolo, D Aldovini, LV Cuorvo, M Frisinghelli, L Fasanella, F Berloffa, M Barbareschi, E Galligioni
Journal: Cancer Research (2010)

Abstract PURPOSE: To examine interactions between mib-1 and clinical-pathological markers and their impact on outcomes. PATIENTS AND METHODS: Mib-1 was identified by immunohistochemical staining in 3402 EIBC pts treated from 1995 to 2008. Mib-1 was defined as low (15%), intermediate (16%-30%) and high (&amp;gt;30%) value. Correlation between mib-1 and age, tumor size (T), nodal status (N), ER, PR, HER-2, grading (G) was performed by X2 test. Log-rank test and Cox regression model were performed to test mib-1 as prognostic factor for overall survival (OS) and Disease Free Survival (DFS) and its correlation with other known prognostic factors. RESULTS: Median mib-1 was 25%. Mib-1 was low in 1135, intermediate in 1094 and high in 1173 pts. Median age was 62 years. High mib-1 was significantly (P&amp;lt;0.001) associated with younger age, ductal type, greater size, positive N, poor G, absent or low ER and/or PR expression level, positive HER-2, triple negative subtypes, larger use of chemo±hormonotherapy. High mib-1 was a significant predictor of worse DFS and OS (P&amp;lt;0.001). At median follow up of 42 months DFS and OS were 83.1 and 84.8% respectively in high, 88.9 and 89.3% in intermediate, 92.7 and 93.6% respectively in low Mib-1 group. There were 401 relapses (12%): 197 (6%) in high, 121 (3.5%) in intermediate and 83 (2,5%) in low mib-1 group. BC deaths were 368 (10.8 %): 178 (5.2%) in high, 117 (3.4%) intermediate and 73 (2.2%) in low mib-1 group. High mib1 was predictive of poorer prognosis in &amp;gt; 40 years pts (P&amp;lt;0.001), small tumors (T1) (P&amp;lt;0.001), N+ (P&amp;lt;0.001) and N0 (p=0.007), G1 (p=0.02), ER+ and/or PR+ (P&amp;lt;0.001), negative HER-2 (p=0.007), ductal type (P&amp;lt;0.001) respect to intermediate and low Mib1. At Cox regression analysis Mib1 showed independent prognostic value. According to the median value, high mib-1 (&amp;gt;25%) resulted a prognostic factor of worse outcome (P&amp;lt;0.001, HR=1.81, 95% CI=1.42-2.29), along with positive lymph nodes (P&amp;lt;0.001, HR=2.14, 95% CI=1.67-2.74), age&amp;lt;40 yrs (p=0.002, HR=1.93, 95% CI=1.30-2.86), greater tumors (P&amp;lt;0.001, HR=3.11, 95% CI=2.21-4.39), and ER/PR positive tumors (P&amp;lt;0.001, HR=1.742, 95% CI=1.305-2.327). CONCLUSIONS: In our experience, Mib-1 confirms to be a significant prognostic biomarker for DFS and OS in EIBC, providing additional information besides other clinico-pathological parameters to help decision-making of treatment. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr P3-10-14.
Gender Differences in Clinical Manifestations of Brugada Syndrome
Authors: Begoña Benito, Andrea Sarkozy, Lluis Mont, Stephan Henkens, Antonio Berruezo, David Tamborero, Dabit Arzamendi, Paola Berne, Ramon Brugada, Pedro Brugada, Josep Brugada
Journal: Journal of the American College of Cardiology (2008)
Solitary Metastasis in Anterior Rib End
Authors: Cheng-Pei Chang, Jyh-Hwa Chen, Yum-Kung Chu, Ming-Huei Sheu, Chen-Ming Sun, Shu-Quinn Liao, Ren-Shyan Liu
Journal: Clinical Nuclear Medicine (2003)

A 70-year-old man underwent a left upper lobectomy for adenocarcinoma of the lung. One and one-half years later, a whole-body bone scan revealed a single, small area of increased uptake in the left fifth anterior rib end, which then extended posteriorly in follow-up scans. A computed tomographic scan demonstrated rib destruction in the corresponding region, with ultrasound-guided biopsy confirming metastatic adenocarcinoma.
Polysaccharide Conjugate Typhoid Vaccine
Authors: Richard L. Guerrant, Margaret Kosek
Journal: New England Journal of Medicine (2001)

There is a growing appreciation of the huge health threat posed by increasingly resistant infectious diseases, especially in tropical areas of the developing world. Only with improved water, sanitation, housing, and education can enteric, parasitic, respiratory, and retroviral infections be controlled. In the industrialized world, development led to the control of typhoid fever, cholera, malaria, and now (at least relative to developing countries) even AIDS. Global development and the reduction of inequalities must therefore be the highest priorities in our efforts to control the diseases of poverty.Important interim measures such as oral rehydration therapy and vaccines are lifesaving in . . .
REPORT OF A CASE OF ANEURISM OF CORONARY ARTERY
Authors: WALTER R. HEWITT
Journal: JAMA (1910)

This case is interesting, first because of its rarity. (On examination of the literature to date, I was able to find only three reported cases, this one making the fourth and being the only case that showed involvement of the right coronary artery); and secondly, because diagnosis has never been made ante-mortem. <h3>Patient.—</h3> C. R., permit No. 6622, a negro man, aged 27, single, laborer, entered the St. Louis City Hospital Nov. 8, 1909. Dyspnea had extended over a period of four weeks, and there was slight edema of both ankles. Examination of the cardiac area revealed a systolic and a diastolic murmur at the base, a systolic and presystolic murmur at the apex and also a loud, rubbing sound over the entire cardiac area. There was no marked distress at this time. The patient's mother died of dropsy; otherwise family history was negative. He had rheumatism in the right
Intravenous nicorandil can preserve microvascular integrity and myocardial viability in patients with reperfused anterior wall myocardial infarction
Authors: Hiroshi Ito, Yoshiaki Taniyama, Katsuomi Iwakura, Nagahiro Nishikawa, Tohru Masuyama, Tsunehiko Kuzuya, Masatsugu Hori, Yorihiko Higashino, Kenshi Fujii, Takazo Minamino
Journal: Journal of the American College of Cardiology (1999)