Low Association of HLA-B27 with Reiter's Syndrome in Blacks
Authors: Muhammad A. Khan, Ali D. Askari, William E. Braun, Carlos J. Aponte
Journal: Annals of Internal Medicine (1979)

Brief Reports1 February 1979Low Association of HLA-B27 with Reiter's Syndrome in BlacksMUHAMMAD A. KHAN, M.D., ALI D. ASKARI, M.D., WILLIAM E. BRAUN, M.D., CARLOS J. APONTE, M.D.MUHAMMAD A. KHAN, M.D.Search for more papers by this author, ALI D. ASKARI, M.D.Search for more papers by this author, WILLIAM E. BRAUN, M.D.Search for more papers by this author, CARLOS J. APONTE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-2-202 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe association between ankylosing spondylitis and HLA-B27 has been noted in all races that have thus far been studied; it tends to be strongest in whites and relatively weaker in blacks (1-3). Reiter's syndrome is also strongly associated with HLA-B27 in whites (1), but has not been well studied in blacks (3). Morris and associates (4) have suggested the use of B27 typing in the clinical evaluation of white male patients with suspected Reiter's syndrome and have predicted that the test would be even more helpful in blacks. We report here the results of our study of the diagnostic usefulness...References1. WOODROW J: Histocompatibility antigens and rheumatic diseases. Semin Arthritis Rheum 6:257-276, 1977 CrossrefMedlineGoogle Scholar2. KHAN M, BRAUN W, KUSHNER I, GRECEK D, MUIR W, and STEINBERG A: HLA-B27 in ankylosing spondylitis: differences in frequency and relative risk in American Blacks and Caucasians. J Rheumatol 4(Suppl 3):39-43, 1977 Google Scholar3. KHAN M: Race-related differences in HLA association with ankylosing spondylitis and Reiter's disease in American blacks and whites. J Natl Med Assoc 70:41-42, 1978 MedlineGoogle Scholar4. MORRIS R, METZGER A, BLUESTONE R, and TERASAKI P: HL-A W27—a clue to the diagnosis and pathogenesis of Reiter's syndrome. N Engl J Med 290:554-556, 1974 CrossrefMedlineGoogle Scholar5. BREWERTON D: HLA-B27 and the inheritance of susceptibility to rheumatic diseases. Arthritis Rheum 19:656-668, 1976 CrossrefMedlineGoogle Scholar6. MCCLUSKY O, LORDON R, and ARNETT F: HL-A 27 in Reiter's syndrome and psoriatic arthritis: A genetic factor in disease susceptibility and expression. J Rheumatol 1:263-268, 1974 Google Scholar7. VAN DEN BERG-LOONEN E, DEKKER-SAEYS B, MEUWISSEN S, NIJENHUIS L, and ENGELFRIET C: Histocompatibility antigens and other genetic markers in ankylosing spondylitis and inflammatory bowel diseases. J Immunogenet 4:167-175, 1977 CrossrefMedlineGoogle Scholar8. KHAN M, KUSHNER I, and BRAUN W: B27-negative HLA-Bw16 in ankylosing spondylitis. Lancet 1:1370-1371, 1978 CrossrefMedlineGoogle Scholar9. KHAN M, KUSHNER I, and BRAUN W: A subgroup of ankylosing spondylitis associated with HLA-B7 in American blacks. Arthritis Rheum 21:528-530, 1978 CrossrefMedlineGoogle Scholar10. ARNETT F, HOCHBERG M, and BIAS W: Cross-reactive HLA antigens in B27-negative Reiter's syndrome and sacroiliitis. Johns Hopkins Med J 141:193-197, 1977 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MUHAMMAD A. KHAN, M.D.; ALI D. ASKARI, M.D.; WILLIAM E. BRAUN, M.D.; CARLOS J. APONTE, M.D.Affiliations: Case Western Reserve University at Cleveland Metropolitan General Hospital Veterans Administration Hospital Cleveland Clinic Cleveland, Ohio PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byVaccination of children in low-resource countries against Shigella is unlikely to present an undue risk of reactive arthritis2 The immunogenetics of the seronegative spondyloarthropathiesHLA-B27 and the Seronegative SpondyloarthropathiesHLA-B27 and the Seronegative SpondyloarthropathiesReactive arthritis in patients attending an urban sexually transmitted diseases clinicHISTOCOMPATIBILITY TYPING IN THE RHEUMATIC DISEASESThe pathogenetic aspects of spondyloarthropathies from the point of view of HLA-B27HLA B27 and clinical features in Reiter's syndromeAcute aortic insufficiency in a patient with presumed Reiter's syndrome.Ankylosing Spondylitis and Other SpondyloarthropathiesReiter's syndrome in an adolescent female with systemic sequelaeHLA and Ankylosing SpondylitisRheumatology and Joint DiseasesCREG antigens differentially influence expression of extraarticular manifestations in whites and blacks with rheumatoid arthritisOrthopedic surgeryDiagnostic Value of HLA-B27 Testing in Ankylosing Spondylitis and Reiter's SyndromeMUHAMMAD A. KHAN, M.D., MOHAMMAD K. KHAN, Ph.D.Association of hla-drw4 with rheumatoid arthritis in black and white patients 1 February 1979Volume 90, Issue 2Page: 202-203KeywordsAnkylosing spondylitisRacial and ethnic issuesReactive arthritis ePublished: 1 December 2008 Issue Published: 1 February 1979 Copyright & Permissions©1979 American College of PhysiciansPDF downloadLoading ...