tbuckley/cabot-search huggingface dataset:
Lathosterol level in plasma is elevated in type III hyperlipoproteinemia, but not in non-type III subjects with apolipoprotein phenotype, nor in type IIa or IIb hyperlipoproteinemia
Authors: H.J.M. Kempen, J.A. Gevers Leuven, H.A. van der Voort, P. de Knijff, L. Havekes
Journal: Metabolism (1991)
Prophylactic anti-tumor effects in a B cell lymphoma model with DNA vaccines delivered on polyethylenimine (PEI) functionalized PLGA microparticles
Authors: Sudhir Pai Kasturi, Hong Qin, Kassandra S. Thomson, Shihab El-Bereir, Soung-chul Cha, Sattva Neelapu, Larry W. Kwak, Krishnendu Roy
Journal: Journal of Controlled Release (2006)
Effect of counselling on the psychiatric morbidity associated with mastectomy.
Authors: P Maguire, A Tait, M Brooke, C Thomas, R Sellwood
Journal: BMJ (1980)

A controlled trial was conducted to determine whether counselling by a specialist nurse prevented the psychiatric morbidity associated with mastectomy and breast cancer. Seventy-five patients were counselled by the nurse and monitored during follow-up, while 77 patients received only the care normally given by the surgical unit. Counselling failed to prevent morbidity, but the nurse9s regular monitoring of the women9s progress led her to recognise and refer 76% of those who needed psychiatric help. Only 15% of the control group whose condition warranted help were recognised and referred. Consequently, 12 to 18 months after mastectomy there was much less psychiatric morbidity in the counselled group (12%) than in the control group (39%). These findings highlight the high degree of psychiatric morbidity in patients who have undergone mastectomy and indicate the need to find ways of reducing this morbidity.
Changes in breast volume during normal menstrual cycle and after oral contraceptives.
Authors: D Milligan, J O Drife, R V Short
Journal: BMJ (1975)

The volume of the left and right breasts was measured daily in four nulliparous women during normal menstrual cycles and after the use of oral contraceptives. Breast volume increased significantly in the second half of both normal and contraceptive-controlled cycles. The mean total change in volume throughout the cycle was 100 ml under natural conditions and 66 ml on oral contraceptives.
The Doctor's Master
Authors: Norman G. Levinsky
Journal: New England Journal of Medicine (1984)

There is increasing pressure on doctors to serve two masters. Physicians in practice are being enjoined to consider society's needs as well as each patient's needs in deciding what type and amount of medical care to deliver. Not surprisingly, many government leaders and health planners take this position. More remarkably, important elements of the medical profession are promoting this view.I would argue the contrary, that physicians are required to do everything that they believe may benefit each patient without regard to costs or other societal considerations. In caring for an individual patient, the doctor must act solely as that . . .
The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.
Authors: J M Lehmann, D D McKee, M A Watson, T M Willson, J T Moore, S A Kliewer
Journal: Journal of Clinical Investigation (1998)

The cytochrome P-450 monooxygenase 3A4 (CYP3A4) is responsible for the oxidative metabolism of a wide variety of xenobiotics including an estimated 60% of all clinically used drugs. Although expression of the CYP3A4 gene is known to be induced in response to a variety of compounds, the mechanism underlying this induction, which represents a basis for drug interactions in patients, has remained unclear. We report the identification of a human (h) orphan nuclear receptor, termed the pregnane X receptor (PXR), that binds to a response element in the CYP3A4 promoter and is activated by a range of drugs known to induce CYP3A4 expression. Comparison of hPXR with the recently cloned mouse PXR reveals marked differences in their activation by certain drugs, which may account in part for the species-specific effects of compounds on CYP3A gene expression. These findings provide a molecular explanation for the ability of disparate chemicals to induce CYP3A4 levels and, furthermore, provide a basis for developing in vitro assays to aid in predicting whether drugs will interact in humans.
Cardiomyocyte-specific expression of CYP2J2 prevents development of cardiac remodelling induced by angiotensin II
Authors: Zuowen He, Xu Zhang, Chen Chen, Zheng Wen, Samantha L. Hoopes, Darryl C. Zeldin, Dao Wen Wang
Journal: Cardiovascular Research (2015)

Cardiac remodelling is one of the key pathological changes that occur with cardiovascular disease. Previous studies have demonstrated the beneficial effects of CYP2J2 expression on cardiac injury. In the present study, we investigated the effects of cardiomyocyte-specific CYP2J2 expression and EET treatment on angiotensin II-induced cardiac remodelling and sought to determine the underlying molecular mechanisms involved in this process. Eight-week-old mice with cardiomyocyte-specific CYP2J2 expression (αMHC-CYP2J2-Tr) and wild-type (WT) control mice were treated with Ang-II. Ang-II treatment of WT mice induced changes in heart morphology, cardiac hypertrophy and dysfunction, as well as collagen accumulation; however, cardiomyocyte-specific expression of CYP2J2 attenuated these effects. The cardioprotective effects observed in α-MHC-CYP2J2-Tr mice were associated with peroxisome proliferator-activated receptor (PPAR)-γ activation, reduced oxidative stress, reduced NF-κB p65 nuclear translocation, and inhibition of TGF-β1/smad pathway. The effects seen with cardiomyocyte-specific expression of CYP2J2 were partially blocked by treatment with PPAR-γ antagonist GW9662. In in vitro studies, 11,12-EET(1 μmol/L) treatment attenuated cardiomyocyte hypertrophy and remodelling-related protein (collagen I, TGF-β1, TIMP1) expression by inhibiting the oxidative stress-mediated NF-κB pathway via PPAR-γ activation. Furthermore, conditioned media from neonatal cardiomyocytes treated with 11,12-EET inhibited activation of cardiac fibroblasts and TGF-β1/smad pathway. Cardiomyocyte-specific expression of CYP2J2 or treatment with EETs protects against cardiac remodelling by attenuating oxidative stress-mediated NF-κBp65 nuclear translocation via PPAR-γ activation.
ASSOCIATION BETWEEN NOVEL BIOMARKERS AND ARTERIAL ELASTICITY INDEX AMONG HEALTHY MULTI-ETHNIC U.S. POPULATION
Authors: Sidakpal S. Panaich, Naga VA Kommuri, Sandip K. Zalawadiya, Vikas Veeranna, Ashutosh Niraj, Gayathri Ravi, Sony Jacob, Luis Afonso
Journal: Journal of the American College of Cardiology (2011)
AORTIC VALVE AREA IN SUBJECTS WITH AORTIC VALVE STENOSIS BY 320-SLICE CT COMPARED WITH CONTINUOUS WAVE DOPPLER BY TRANSTHORACIC ECHOCARDIOGRAM CONSIDERING AORTIC VALVE CALCIFICATION AND LEFT VENTRICULAR EJECTION FRACTION
Authors: Akihisa Kataoka, Kwanghow Lee, Masae Uehara, Nobusada Funabashi
Journal: Journal of the American College of Cardiology (2011)
MLL gene rearrangements have no direct impact on Ara-C sensitivity in infant acute lymphoblastic leukemia and childhood M4/M5 acute myeloid leukemia
Authors: R W Stam, I Hubeek, M L den Boer, J G C A M Buijs-Gladdines, U Creutzig, G J L Kaspers, R Pieters
Journal: Leukemia (2005)
A prospective evaluation of liver biopsy prior to, and at the time of early hepatic dysfunction following, bone marrow transplantation (BMT)
Authors: N. Azar, D. Valla, V. Leblond, I.Abd-Al Samad, F. Lunel, P. Grippon, Y. Le Charpentier, J.L. Binet, P. Opolon
Journal: Journal of Hepatology (1990)
Acute hemodynamic interventions shift the diastolic pressure-volume curve in man.
Authors: E L Alderman, S A Glantz
Journal: Circulation (1976)

Frame-by-frame analysis of angiograms in 16 patients revealed that hemodynamic interventions are capable of producing substantial shifts in the diastolic pressure-volume curve. Angiotensin raises blood pressure and shifts the entire pressure-volume curve up, and nitroprusside lowers blood pressure and shifts the curve down. Indirect measurements of pleural pressure in seven patients (via esophageal pressure) showed that pleural pressure changes were too small to account for these shifts. Analyzing our results in terms of a theoretical pressure-volume equation previously validated in dog studies did not show the observed shifts to be the product of acute changes in the elasticity of the myocardium itself. This same analysis suggested that indirect changes in the external mechanical constraints acting on the left ventricle such as the right ventricular pressure, the pericardium, and perhaps viscoelastic effects related to changes in filling rate account for the pressure-volume curve shifts with intervention. The fact that one cannot in general relate a specific volume to a given pressure in the face of hemodynamic interventions calls into question the use of end-diastolic pressure interchangeably with end-diastolic fiber length when interpreting systolic events in terms of the Frank-Starling mechanism.
Baby milk manufacturers agree out of court settlement
Authors: Judy Siegel-Itzkovich
Journal: BMJ (2004)

Junior hospital doctors throughout Europe were supposed to start a new, shorter, 58 hour week from this month.Aimed at improving their working livesand their patients' safety-the European directive aims to reduce the limit further to just 48 hours by 2009.But despite the new rules, many doctors will continue to work long hours.United Kingdom: A recent survey of 100 NHS chief executives by the NHS Confederation, which represents NHS management, showed that 16% did not expect their trusts to have complied with the European Working Time Directive by 1 August.Junior doctors could take their employers to employment tribunals, and hospitals will be liable to fines of up to £5000 ($9200; €7600) from the Health and Safety Executive each time they break the directive.The BMA said that it will support UK doctors who take legal action against employers that do not limit their working hours to those set out in the directive.The NHS has been struggling to meet the requirements of the new directive, but it is not alone in failing to do so fully.Austria: Compliance with
Phasic effects of vagal stimulation on pacemaker activity of the isolated sinus node of the young cat.
Authors: J Jalife, G K Moe
Journal: Circulation Research (1979)

We studied the functional interactions between the sinoatrial (SA) nodal pacemaker and the vagus nerve in isolated right atrium-vagus nerve preparations of the kitten.Brief trains of stimuli applied to the vagus nerve scanning the spontaneous pacemaker cycle induce a brief hyperpolarization of the membrane of cells in the pacemaker region.Aa a result of this hyperpolarization, there occur phasic changes in pacemaker cycle length that depend on the timing, amplitude, and duration of the hyperpolarization and, also, on the relationship between the duration of the hyperpolarization and the pacemaker cycle length.If the duration of the hyperpolarization is long relative to the duration of the spontaneous cycle, the next discharge can be delayed but not accelerated, no matter when during the cycle vagal stimuli are applied.If the duration of the hyperpolarization is briefer than the spontaneous cycle and the vagal input is presented early in the cycle, a postinhibitory rebound accelerates the next discharge.These effects of the vagal burst on the pacemaker cycle can be described by an inhibitory curve consisting of several components: a latent period of about 200 msec, a phase of major prolongation of the first and sometimes the second pacemaker cycle, a phase of relative or actual acceleration, and a final phase of lesser deceleration lasting several seconds.These effects can be approximated closely in a sucrose gap preparation of the sinus node by brief hyperpolarizing current pulses spanning the spontaneous pacemaker cycle in the test compartment.
Suppressed Soft Tissue Uptake of Ga-67 After Blood Transfusion and Chemotherapy
Authors: Lester C. H. Leong, Yvonne Y. Ho
Journal: Clinical Nuclear Medicine (2005)

We report 2 cases of diffusely increased gallium-67 (Ga-67) skeletal uptake with suppressed soft tissue uptake and highlight the importance of a detailed clinical history, because this affects scan interpretation. Suppressed soft tissue uptake of Ga-67 occurs in hyperferremia. Iron has a high affinity for transferrin, and Ga-67 is unable to displace iron-bound transferrin. This leads to suppressed soft tissue uptake and relatively higher Ga-67 bone activity with increased urinary activity. Causes of hyperferremia include red cell transfusion, chemotherapy, and hereditary hemochromatosis. Chemotherapy increases blood iron levels by suppressing erythropoiesis. Other causes include recent radiotherapy and gadolinium for magnetic resonance imaging (MRI).
Disseminated papular lesions in an HIV infected patient
Authors: C.-Y. Tseng, S.-C. Su, N.-C. Chiu, C.-Y. Lin
Journal: BMJ (2014)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following Disseminated papular lesions in an HIV infected patient Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
483 IMPORTANCE OF HCV RNA ASSAY CHARACTERISTICS AND DIFFERENCES BETWEEN ASSAYS FOR RESPONSE GUIDED THERAPY OF CHRONIC HEPATITIS C
Authors: V. Weich, S. Schwendy, B. Möller, N. Dikopoulos, P. Buggisch, J. Encke, G. Teuber, T. Goeser, R. Thimme, H. Klinker, W. Boecher, E. Schulte-Frohlinde, S. Zeuzem, T. Berg, C. Sarrazin
Journal: Journal of Hepatology (2011)
Transition of pityriasis lichenoides et varioliformis acuta to febrile ulceronecrotic Mucha-Habermann disease is associated with elevated serum tumour necrosis factor-alpha
Authors: A. Tsianakas, P.H. Hoeger
Journal: British Journal of Dermatology (2005)

Journal Article Transition of pityriasis lichenoides et varioliformis acuta to febrile ulceronecrotic Mucha–Habermann disease is associated with elevated serum tumour necrosis factor‐α Get access A. Tsianakas, A. Tsianakas Division of Paediatric Dermatology, Department of Dermatology, University of Hamburg, Martinistr. 52, D‐20246 Hamburg, Germany Search for other works by this author on: Oxford Academic Google Scholar P.H. Hoeger P.H. Hoeger Division of Paediatric Dermatology, Department of Dermatology, University of Hamburg, Martinistr. 52, D‐20246 Hamburg, Germany P.H. Hoeger. E‐mail: hoeger@uke.uni‐hamburg.de Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 152, Issue 4, 1 April 2005, Pages 794–799, https://doi.org/10.1111/j.1365-2133.2005.06485.x Published: 01 April 2005 Article history Accepted: 20 September 2004 Published: 01 April 2005
Drugs as a Cause of Fixed, Dilated Pupils After Resuscitation
Authors: Narayan P. Verma
Journal: JAMA (1986)

To the Editor.—  Sometimes we are consulted by the residents covering the medical and cardiac intensive care units to consider or rule out brain death in a patient who has recently been transferred from the emergency department after a successful cardiopulmonary resuscitation and advanced cardiac life support but is found to have dilated and fixed pupils when first examined by the resident covering the intensive care unit. An important point, often not emphasized in daily rounds and certainly not in current medical and neurological texts, is the role of large doses of atropine (a parasympatholytic drug) and dopamine (a sympathomimetic drug) in the causation of this phenomenon during the immediate postresuscitation period. These two medications are liberally used, singly or in combination, during advanced cardiac life support and they act synergistically to cause pupillary dilation. The latter, when associated with unreactivity (secondary to atropine or hypoxia or both), is considered
Cell death by apoptosis is a feature of the rheumatoid nodule
Authors: J Highton
Journal: Annals of the Rheumatic Diseases (2002)

Objective: To examine the site and extent of apoptosis in the rheumatoid nodule and to determine whether this process make a significant contribution to the control of inflammation in the rheumatoid nodule as in other granulomas. Methods: Nine nodules and seven synovial membranes were examined by terminal deoxynucleotidyl transferase-mediated nick end labelling (TUNEL) in situ and a subset was further examined by DNA electrophoresis. The phenotype of apoptotic cells was identified using monoclonal antibodies and immunohistology. Results: Apoptosis occurred in all zones of the nodule and, except in one case, was not focused adjacent to the necrotic centre. Apoptosis occurred in 3.5 (4.5)% (mean (SD)) of cells in the nodule and 3.6 (3.1)% of cells in synovial membranes. Apoptosis was more common in nodule T cells (4.1 (2.9)%) than fibroblasts (1.0 (1.4)%), p = 0.01. Among macrophages 3.2 (4.7)% were apoptotic. Banding of DNA consistent with apoptosis was seen in two of three nodules examined. Conclusion: Apoptosis occurs at a low level in the nodule, similar to the synovial membrane. The results suggest that two modes of cell death occur in the nodule: apoptosis, which occurs throughout the nodule; and necrosis, which is concentrated near the necrotic centre. Apoptosis was more common in infiltrating inflammatory cells than in resident fibroblasts. These results are consistent with the proposal that apoptosis of infiltrating inflammatory cells is important in controlling accumulation of cells in the rheumatoid nodule as has been established in experimental granulomas.
Lack of relevance of the acetylator status on dapsone response in chronic autoimmune thrombocytopenic purpura
Authors: H. Le Lou�t, M. Ruivart, P. Bierling, J.C. Duche, B. Godeau
Journal: American Journal of Hematology (1999)

Dapsone provides an alternative treatment for patients with chronic autoimmune thrombocytopenic purpura (AITP) who had inadequate response to conventional therapy. However, the efficacy of this treatment is achieved in only 50% of patients. Dapsone is partly metabolized by the polymorphic N-acetyltransferase 2% and 50% of Caucasian patients show a genetically determined slow acetylator phenotype. The aim of our study was to investigate the influence of the acetylator status on dapsone efficacy in patients with chronic AITP. Nineteen caucasian adults with chronic AITP, previously treated by dapsone, were included in the study. Acetylator phenotype was determined by using a caffeine urinary test. Among the fourteen fast acetylator patients, eight patients exhibited positive response to dapsone and six patients did not. Among the five slow acetylator patients, one patient displayed a positive response to dapsone. Comparison of data by using the Fisher's exact test did not reach statistical significance. Our results do not support a relationship between dapsone efficacy and acetylator status in adults with chronic AITP.
Standards Setting and the Joint Commission on Accreditation of Hospitals: The Right and the Responsibility of Medicine
Authors: JOHN R. BALL
Journal: Annals of Internal Medicine (1983)

Editorials1 April 1983Standards Setting and the Joint Commission on Accreditation of Hospitals: The Right and the Responsibility of MedicineJOHN R. BALL, M.D., J.D.JOHN R. BALL, M.D., J.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-98-4-549 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe hallmark of any profession is the right—and the consequent responsibility—to establish and to enforce its own standards. Both the right and the responsibility of medicine are now at issue in the proposed revision of the Accreditation Manual for Hospitals of the Joint Commission on Accreditation of Hospitals (JCAH). Particularly at issue are the JCAH standards on the composition, structure, and functions of the hospital's medical staff. Perhaps no other topic in the past decade has been debated so acutely within the medical profession.The JCAH was formed in 1951 by the American College of Surgeons (ACS), the American College...References1. . Accreditation Manual for Hospitals, 1983 Edition. Chicago: Joint Commission on Accreditation of Hospitals; 1982:v. Google Scholar2. . Accreditation Manual for Hospitals, 1983 Edition. Chicago: Joint Commission on Accreditation of Hospitals; 1983:ix. Google Scholar3. . "Organized Staff, Standard I, Required Characteristic 1.A." Chicago: Joint Commission on Accreditation of Hospitals. (Proposed revision of 11 December 1982 circulated for field review.) Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByQuality of Care and the Accreditation of Health Services: What is the Relationship?Quality of Care and the Accreditation of Health Services: What is the Relationship? 1 April 1983Volume 98, Issue 4Page: 549-551KeywordsAcute coronary syndromeHospital medicineMedical staffSurgeons Issue Published: 1 April 1983 PDF DownloadLoading ...
THERAPEUTIC USE OF LOCALIZED ALLERGY
Authors: Paul D. Garvin
Journal: JAMA (1935)

During the last few years extensive studies have been made on the circulating antibody (atopic reagin) usually present in atopy, as well as the reaction of the sensitized tissue when brought in contact with the atopen. The discovery by Prausnitz and Küstner<sup>1</sup>in 1921 that the normal skin can be passively sensitized by the intradermal injection of serum containing atopic reagin has been utilized for the diagnosis of atopic conditions. Walzer<sup>2</sup>in 1926 demonstrated that the passive transfer site often reacts in the characteristic manner when the specific atopen is ingested orally instead of injected into the sensitized area. The histologic picture of the allergic wheal has recently been studied by Kline and his associates.<sup>3</sup>They find that the essential picture is an inflammation of the dermis and subcutaneous tissue, with edema, vascular engorgement and leukocytosis. At first the eosinophilic leukocytes predominate (first hour), but later the polymorphonuclear neutrophilic and