Comparison of Laboratory Findings and Medication Levels to Control Urticaria According to Asst Reactivity in Chronic Idiopathic Urticaria
Authors: Seong-Wook Sohn, Soo-Kyeong Lee
Journal: Journal of Allergy and Clinical Immunology (2013)

RationalePositivity in autologous serum skin test (ASST) is reported in up to 60% of patients with CIU. However, severity and laboratory findings according to ASST reactivity are poorly understood. The purpose of this study was to compare laboratory findings and medication levels to control urticaria between ASST positive and negative patients in CIU.MethodsWe reviewed anti-microsome (AMC) antibody, anti-thyroglobulin (ATG) antibody, total IgE, Complement 4 (C4) levels, rheumatoid factor (RF), ESR, D-dimer and medication levels to control urticaria in 166 patients with CIU retrospectively.ResultsSixty nine patients (41.6%) are positive in ASST. No statistical differences are observed between 2 groups in laboratory findings such as AMC Ab, ATG Ab, total IgE, C4 levels, RF, ESR, and D-dimer (P>0.05). Eight patients (11.6%) of ASST positive groups and 6 patients (6.2%) of ASST negative groups need medication of level 4 (usage of cyclosporine, dapsone or anti-IgE) to control urticaria. However, it is not statistically different between 2 groups (P>0.05).ConclusionsPositive ASST are over 40% in CIU. However laboratory findings and medication to control symptoms are not different according to ASST reactivity. Other factors might be considered to be involved in the pathogenesis of CIU. Further studies are needed. RationalePositivity in autologous serum skin test (ASST) is reported in up to 60% of patients with CIU. However, severity and laboratory findings according to ASST reactivity are poorly understood. The purpose of this study was to compare laboratory findings and medication levels to control urticaria between ASST positive and negative patients in CIU. Positivity in autologous serum skin test (ASST) is reported in up to 60% of patients with CIU. However, severity and laboratory findings according to ASST reactivity are poorly understood. The purpose of this study was to compare laboratory findings and medication levels to control urticaria between ASST positive and negative patients in CIU. MethodsWe reviewed anti-microsome (AMC) antibody, anti-thyroglobulin (ATG) antibody, total IgE, Complement 4 (C4) levels, rheumatoid factor (RF), ESR, D-dimer and medication levels to control urticaria in 166 patients with CIU retrospectively. We reviewed anti-microsome (AMC) antibody, anti-thyroglobulin (ATG) antibody, total IgE, Complement 4 (C4) levels, rheumatoid factor (RF), ESR, D-dimer and medication levels to control urticaria in 166 patients with CIU retrospectively. ResultsSixty nine patients (41.6%) are positive in ASST. No statistical differences are observed between 2 groups in laboratory findings such as AMC Ab, ATG Ab, total IgE, C4 levels, RF, ESR, and D-dimer (P>0.05). Eight patients (11.6%) of ASST positive groups and 6 patients (6.2%) of ASST negative groups need medication of level 4 (usage of cyclosporine, dapsone or anti-IgE) to control urticaria. However, it is not statistically different between 2 groups (P>0.05). Sixty nine patients (41.6%) are positive in ASST. No statistical differences are observed between 2 groups in laboratory findings such as AMC Ab, ATG Ab, total IgE, C4 levels, RF, ESR, and D-dimer (P>0.05). Eight patients (11.6%) of ASST positive groups and 6 patients (6.2%) of ASST negative groups need medication of level 4 (usage of cyclosporine, dapsone or anti-IgE) to control urticaria. However, it is not statistically different between 2 groups (P>0.05). ConclusionsPositive ASST are over 40% in CIU. However laboratory findings and medication to control symptoms are not different according to ASST reactivity. Other factors might be considered to be involved in the pathogenesis of CIU. Further studies are needed. Positive ASST are over 40% in CIU. However laboratory findings and medication to control symptoms are not different according to ASST reactivity. Other factors might be considered to be involved in the pathogenesis of CIU. Further studies are needed.