Angina Pectoris and Therapy with Cisplatin, Vincristine, and Bleomycin
Authors: Andrew C. Dixon, Jeffrey M. Nakamura, Noboru Oishi, Dennis H. Wachi, Osamu Fukuyama
Journal: Annals of Internal Medicine (1989)

Letters and Corrections15 August 1989Angina Pectoris and Therapy with Cisplatin, Vincristine, and BleomycinAndrew C. Dixon, MD, Jeffrey M. Nakamura, MD, Noboru Oishi, MD, Dennis H. Wachi, MD, Osamu Fukuyama, MDAndrew C. Dixon, MD, Jeffrey M. Nakamura, MD, Noboru Oishi, MD, Dennis H. Wachi, MD, Osamu Fukuyama, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-111-4-342 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: Combination chemotherapy with cisplatin, a vinca alkaloid, and bleomycin has been widely used in the therapy of several malignancies. Recently, various types of vascular toxicity have been reported in patients receiving these drugs. We describe a patient who developed angina pectoris related to the administration of this chemotherapeutic regimen.A 64-year-old Japanese man with a biopsy-proven recurrence of a squamous cell carcinoma of the oropharynx was treated with cisplatin, 70 mg/m2 body surface area, vincristine, 1.2 mg/m2 body surface area, and bleomycin, 12 units/m2 body surface area, on three separate occasions. Each time, on the morning after...References1. EdwardsLaneSmith GMF. Long-term treatment with cisdichlorodiammineplatinum (II ) -vinblastine-bleomycin : possible association with severe coronary artery disease. Cancer Treat Rep. 1979;63:551-2. MedlineGoogle Scholar2. GrauGrauMiliaEstapeMulet JMAJM. Cancer chemotherapy and Raynaud's phenomenon. Ann Intern Med. 1983;98:258. LinkGoogle Scholar3. WhiteSchwartzbergKrisBosl DLMG. Acute chest pain syndrome during bleomycin infusions. Cancer. 1987;59:1582-5. CrossrefMedlineGoogle Scholar4. StefenelliKuzmitsUlrichGlogar TRWD. Acute vascular toxicity after combination chemotherapy with cisplatin, vinblastine, and bleomycin for testicular cancer. Eur Heart J. 1988;9:552-6. CrossrefMedlineGoogle Scholar5. DollListGrecoHainsworthHandeJohnson DAFJKD. Acute vascular ischemic events after cisplatin-based chemotherapy for germ-cell tumors of the testis. Ann Intern Med. 1986; 105:48-51. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Andrew C. Dixon, MD; Jeffrey M. Nakamura, MD; Noboru Oishi, MD; Dennis H. Wachi, MD; Osamu Fukuyama, MDAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byChemoradiation therapy for non-small cell lung cancer exacerbates thoracic aortic calcification determined by computed tomographyCommon Vascular Toxicities of Cancer TherapiesMechanisms of Cardiovascular Damage Induced by Traditional ChemotherapyVascular Toxicities of Cancer TherapiesVascular Toxicities of Cancer TherapiesVinca alkaloidsThe Crossroads of Geriatric Cardiology and Cardio-OncologyDRUGS USED IN CANCER CHEMOTHERAPYADVERSE CARDIOVASCULAR EFFECTS OF NON-CARDIOVASCULAR DRUGSVinca alkaloidsCytostatic drugs 15 August 1989Volume 111, Issue 4Page: 342-343KeywordsAdverse reactionsAlkaloidsAnginaBody surface areaCombination chemotherapyOropharynxSquamous cell carcinomaToxicity ePublished: 1 December 2008 Issue Published: 15 August 1989 PDF downloadLoading ...