Changes in Renal Morphology
Authors: GEORGE J. HILL
Journal: Annals of Internal Medicine (1964)

Clinical Staff Conference1 August 1964Changes in Renal MorphologyGEORGE J. HILL II, M.D.GEORGE J. HILL II, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-2-349 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn early laboratory and clinical investigations of amphotericin B, the lethal dose range in animals and certain aspects of renal toxicity in animals and man were described (1, 2). Renal histologic changes were not recognized, however (3). In 1961 and 1962 isolated instances of nephrocalcinosis (4-7) were first reported, and soon thereafter a spectrum of renal histologic changes was attributed to amphotericin B therapy (8-11).This is a summary of our experience to date with renal biopsy and necropsy studies in humans and dogs.A. HUMAN STUDIES1. BIOPSY STUDIESIn ten amphotericin B treated and in three untreated patients...References1. STERNBERGWRIGHTOURA THETM: A new antifungal antibiotic amphotericin B, in Antibiotics Annual 1955-1956, Medical Encyclopedia, Inc., New York, 1956, p. 566. Google Scholar2. UTZLOURIAFEDEREMMONSMCCULLOUGH JPDBNCWNB: A report of clinical studies on the use of amphotericin in patients with systemic fungal diseases, in Antibiotics Annual 1957-1958, Medical Encyclopedia, Inc., New York, 1958, p. 65. Google Scholar3. BELLANDRIOLESABESINUTZ NHVTSMJP: On the nephrotoxicity of amphotericin B in man. Amer. J. Med. 33: 64, 1962. CrossrefMedlineGoogle Scholar4. SANFORDRASCHSTONEHILL WGJRRB: The use of amphotericin B in the treatment of disseminated coccidiodomycosis with special reference to nephrotoxicity, in Coccidiodomycosis Cooperative Study. Transactions of the Sixth Annual Meeting of the VA-Armed forces Coccidiodomycosis Cooperative Study, November 30 and December 1, 1961, p. 35. Google Scholar5. 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Author, Article, and Disclosure InformationAuthors: GEORGE J. HILLII, M.D.Affiliations: Bethesda, Maryland PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byUpdate on Invasive CandidiasisRenal magnesium wasting associated with amphotericin B therapyDiagnosis and Treatment of Systemic MycosesRenal tubular acidosis: Pathophysiology, diagnosis and treatment3 Biological Activity of Polyene AntibioticsSpontaneous Resolution of Endogenous Candida Endophthalmitis Complicating Intravenous HyperalimentationRenal Ultrastructure After Amphotericin BChemistry and biology of the polyene macrolide antibioticsNephrotoxicity of amphotericin B, with emphasis on changes in tubular function 1 August 1964Volume 61, Issue 2Page: 349-354KeywordsAmphotericinBiopsyClinical laboratoriesLethal doseNecrosisResearch laboratoriesToxicity ePublished: 1 December 2008 Issue Published: 1 August 1964 PDF downloadLoading ...