tbuckley/cabot-search huggingface dataset:
Pancreatitis—A Rare Complication?
Authors: Melvyn J. Michaelian
Journal: JAMA (1975)

To the Editor.—  Numerous articles have been published on pancreatitis and some of the ensuing common complications. Recently, we saw a patient who had pancreatitis and a possible complication that may or may not have been associated with his primary disease process.  Report of a Case. —  This 47-year-old man was admitted to the hospital with a twoweek history of abdominal pain, primarily located in the left side of his abdomen, with some radiation to the left shoulder and down toward the left hip. The patient stated that the pain was not associated with eating and was not relieved with analgesics. There was history of previous peptic ulcer disease, but no gallbladder disease. The patient denied any change in his bowel habits. On admission, blood pressure was 120/80 mm Hg, hemoglobin value was 13.5 mg/100 ml, and white blood cell count was 9,000, with a normal differential cell count.
Government pushes ahead with plan for cheaper drugs deal for NHS
Authors: Nicholas Timmins
Journal: BMJ (2007)

Ministers want to switch the way the NHS pays for the £8bn (€12bn; $16bn) worth of branded drugs that it buys each year. They want to move to a system in which drug prices are based on the benefits they bring to patients—and it seems they want to do so quickly.

The radical move comes after a report from the Office of Fair Trading (OFT) in February that recommended such a shift from 2010, when the current 50 year old pharmaceutical price regulation scheme (PPRS) becomes due for its five yearly renewal ( BMJ 2007;334:383 doi: 10.1136/bmj.39133.543438.DB) .

The industry had been expecting a response but not last …
Israeli health ministry officials face charges relating to faulty baby formula
Authors: Judy Siegel-Itzkovich
Journal: BMJ (2008)

Nearly five years after an imported baby formula that was lacking in thiamin (vitamin B1) allegedly caused beriberi in Israeli babies fed solely with the product, eight people, including a senior health ministry physician, have been indicted for causing the deaths by negligence of three infants and severe or potentially severe injury in more than 20 others.

The kosher, soya based powder, prepared solely for Israel by the German company Humana, did not include a thiamin supplement in a new formula it began manufacturing in 2003 (bmj.com, 15 Nov 2003, News Extra doi: 10.1136/bmj.327.7424.1128-i).

Although senior officials in the Israeli import company Remedia allegedly knew (according to the indictment) that Humana had decided to stop adding the vitamin, they did nothing about it and did not …
Abnormal Sulfobromophthalein Metabolism in Rotor's Syndrome and Obligate Heterozygotes
Authors: Enrique Wolpert, Flora M. Pascasio, Allan W. Wolkoff, Irwin M. Arias
Journal: New England Journal of Medicine (1977)

Rotor's syndrome is an inheritable disorder characterized by chronic nonhemolytic, predominantly conjugated hyperbilirubinemia without abnormal hepatic pigmentation.1 2 3 4 Because of clinical similarities, Rotor's syndrome has been considered to be a variant of the Dubin-Johnson syndrome.2 , 3 , 5 Recent studies of urinary coproporphyrin excretion, however, demonstrate that the two syndromes are distinct pathophysiologic entities.6 Studies of hepatic transport of sulfobromophthalein in patients with the Dubin-Johnson syndrome reveal a rise in plasma sulfobromophthalein concentration 90 to 120 minutes after intravenous injection of 5 mg of dye per kilogram.7 8 9 10 Moreover, hepatic transport maximum (Tm) is virtually zero, with a normal relative storage capacity (S), . . .
Report of 24 Cases of Myocardial Infarction Treated at Home
Authors: R. A. Sleet
Journal: BMJ (1968)

During a four-year period in one general practice 50 patients suffered myocardial infarction; 24 were dead before their general practitioner saw them. Of the surviving 26, 2 were admitted to hospital for social reasons and the others were treated in their homes. One woman suffered a pulmonary embolus on the tenth day of her illness and was admitted to hospital. Three patients were found to develop arrythmias; one of these died. One other patient died, but the others made uneventful recoveries. These results compare well with those obtained by specialist units, perhaps because the advantages of such a unit are balanced by the hazards of transportation to it.
STUDIES ON COLLATERAL CIRCULATION. II. THERMIC CHANGES AFTER ARTERIAL LIGATION, SECTION OF SPINAL CORD OR POSTERIOR ROOTS AND GANGLIONECTOMY
Authors: Samuel C. Harvey, Béla Halpert
Journal: Journal of Clinical Investigation (1931)

Previous experiments (1) have shown that in the dog ligation of both external iliac arteries close to their origin caused a decrease in the temperature of both hind feet to room temperature and that cutting of the rami communicantes and removal of the tributary sympathetic ganglia caused a rise in temperature of the corresponding foot to about that before ligation.The present experiments were planned to ascertain (a) whether division of the spinal cord at about the level of the first lumbar vertebra, and (b) section of the posterior roots below this level would influence the above reaction.METHOD
Central Microtubular Agenesis Causing Primary Ciliary Dyskinesia
Authors: Wendy Stannard, Andrew Rutman, Colin Wallis, Chris O'Callaghan
Journal: American Journal of Respiratory and Critical Care Medicine (2004)

Primary ciliary dyskinesia is an autosomal recessive disorder characterized by chronic upper and lower respiratory tract symptoms. We report the diagnosis of primary ciliary dyskinesia associated with a circular ciliary beat pattern in three siblings. This beat pattern is consistent with a ciliary transposition defect, where a peripheral microtubule doublet is transposed to the center of the ciliary axoneme to replace the absent central microtubule pair. However, in these siblings, ultrastructural analysis of the cilia revealed an absence of the central microtubule pair only. This variant of transposition with a circular ciliary beat pattern has not been described previously. In addition, this defect, together with the transposition defect, may help explain the mechanism of the circular beat pattern and also the absence of situs inversus in these patients.
Abstract 2353: Novel inhibitors of PIM-1, PIM-2, and PIM-3 protein kinases: medicinal chemistry leading to AZD1208.
Authors: Michelle L. Lamb, Les A. Dakin, Michael H. Block, Huawei Chen, Erin Code, James E. Dowling, Xiaomei Feng, Andrew D. Ferguson, Isabelle Green, Alexander W. Hird, Tina Howard, Dennis Huszar, Erika K. Keeton, Paul D. Lyne, Hannah Pollard, Michael Rooney, Jon Read, Allan J. Wu, Tao Zhang, Xiaolan Zheng
Journal: Cancer Research (2013)

Abstract The PIM serine/threonine kinase family, composed of three highly homologous members, PIM-1, PIM-2 and PIM-3, are upregulated in leukemias and lymphomas, including AML, NHL and CLL, highlighting the potential of these kinases as therapeutic targets in these indications. Over-expression of PIM-1 or PIM-3 has also been observed several solid tumors, in particular prostate, pancreatic, gastric, bladder and hepatocellular cancers. PIM kinases are downstream effectors of many cytokine and growth factor signaling pathways and are direct transcriptional targets of STAT transcription factors activated by these pathways, thereby mediating cell proliferation and survival. We have identified novel, potent and highly selective inhibitors of the PIM family kinases. The synthesis, X-ray crystallographic binding mode, and SAR of this benzylidene-1,3-thiazolidine-2,4-dione series are described. Examples from this series exhibit single digit nanomolar potency against all three PIMs, and have been shown to be selective across a panel of more than 440 kinases, with inhibition found for only approximately 3% of the panel, and at least 10-fold selectivity over kinases outside the PIM family. The compounds additionally are stable in rat microsomes, have high aqueous solubilities, and are not potent against the hERG ion channel. The series has antiproliferative activity in a panel of AML cells, has excellent pre-clinical pharmacokinetic properties, and lead compounds have shown strong tumor growth inhibition in vivo in mouse AML xenograft models. From this series, AZD1208 has recently entered Phase I clinical trials for AML and solid tumors. Citation Format: Michelle L. Lamb, Les A. Dakin, Michael H. Block, Huawei Chen, Erin Code, James E. Dowling, Xiaomei Feng, Andrew D. Ferguson, Isabelle Green, Alexander W. Hird, Tina Howard, Dennis Huszar, Erika K. Keeton, Paul D. Lyne, Hannah Pollard, Michael Rooney, Jon Read, Allan J. Wu, Tao Zhang, Xiaolan Zheng. Novel inhibitors of PIM-1, PIM-2, and PIM-3 protein kinases: medicinal chemistry leading to AZD1208. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2353. doi:10.1158/1538-7445.AM2013-2353
Widening of the Excitable Gap and Enlargement of the Core of Reentry During Atrial Fibrillation With a Pure Sodium Channel Blocker in Canine Atria
Authors: Ayaka Kawase, Takanori Ikeda, Kazuo Nakazawa, Takashi Ashihara, Tsunetoyo Namba, Tetsuya Kubota, Kaoru Sugi, Hironori Hirai
Journal: Circulation (2003)

Background— This study aimed to assess the effects of pilsicainide, a pure sodium channel blocker, on electrophysiological action and wavefront dynamics during atrial fibrillation (AF). Methods and Results— In a newly developed model of isolated, perfused, and superfused canine atria (n=12), the right and left endocardia were mapped simultaneously by use of a computerized mapping system. AF was induced with 1 to 5 μmol/L acetylcholine. The antifibrillatory actions of pilsicainide on AF cycle length (AFCL), refractory period (RP), conduction velocity (CV), excitable gap (EG), and the core of the mother rotor were studied. The RP was defined as the shortest coupling interval that could capture the fibrillating atrium. The EG was estimated as the difference between the AFCL and RP. At baseline, multiple wavefronts were observed. After 2.5 μg/mL infusion of pilsicainide, all preparations showed irregular activity, and AF was terminated in 2 preparations. The AFCL and RP were prolonged, and CV was decreased significantly. The EG was widened (147%; P &lt;0.01), and the core perimeter was increased (100%; P &lt;0.01). Increasing the dosage either terminated AF (6 preparations) or converted to organized activity (ie, atypical atrial flutter) (4 preparations). On the maps, all “unorganized” AFs were terminated with the excitation of the core of the mother rotor by an outside wavefront, whereas in preparations with atrial flutter, pilsicainide did not terminate its activity. Conclusions— Widening of the EG by pilsicainide facilitates the excitation of the core of the mother rotor, leading to the termination of AF. In some experiments, pilsicainide converts AF to persistent atrial flutter.
When and why are babies weaned ?
Authors: P Stanway
Journal: BMJ (1978)

the limits of their own recognised competence in both diagnosis and treatment, but I think that Dr Waxman's use of the term "lay" is ambiguous.While "lay" originally meant "non-clerical," it is now sometimes understood to mean "non-medical," and hence his reference to "lay therapists'' in the first paragraph of his letter is perhaps misleading.The fact that his own society is helping to give training in hypnosis to professionals who are neither medically nor dentally qualified should make clear the recognised status of hypnosis in therapy today.
Sulphinpyrazone in acute myocardial infarction: studies on cardiac rhythm and renal function.
Authors: R G Wilcox, D Richardson, J R Hampton, J R Mitchell, D C Banks
Journal: BMJ (1980)

Ninety-eight patients with acute myocardial infarction were randomly allocated to receive sulphinpyrazone 200 mg four times daily or placebo on admission to a coronary care unit. Twenty-four-hour electrocardiogram tape recordings showed no significant reduction in serious arrhythmias in the sulphinpyrazone-treated group. In addition to the expected all in serum urate concentration, patients taking sulphinpyrazone showed a persistent increase in their serum urea and creatinine concentrations when compared with those in the placebo groups (p &lt; 0.05 and p &lt; 0.01 respectively). These differences could not be accounted for by differences in the extent and severity of the infarction between the two groups. These results suggest that sulphinpyrazone has no discernible antiarrhythmic effect in acute myocardial infarction.
Uptake of chloroquine and hydroxychloroquine by human blood leucocytes in vitro: relation to cellular concentrations during antirheumatic therapy.
Authors: J K French, N P Hurst, M L O'Donnell, W H Betts
Journal: Annals of the Rheumatic Diseases (1987)

The accumulation of chloroquine and hydroxychloroquine in unfractionated mononuclear cells and in purified monocytes, lymphocytes, and neutrophil polymorphonuclear leucocytes (PMN) was measured in vitro. Accumulation of both drugs in leucocytes was time and dose dependent. Cellular levels comparable to those found during antirheumatic therapy were achieved by preincubation for 60 minutes with up to 0.1 mM chloroquine or hydroxychloroquine.
EPHEDRINE IN THE TREATMENT OF BRONCHIAL ASTHMA IN CHILDREN
Authors: GEORGE F. MUNNS
Journal: JAMA (1927)

The early reports on the action and uses of ephedrine<sup>1</sup>indicated that it should be a valuable remedy for the relief of attacks of bronchial asthma in children as well as in adults. The first work revealed that ephedrine was effective when given orally, and that the relief given often lasted as long as twenty-four hours and seldom less than four hours. As far as could be determined, a tolerance for the drug was not established. During the last few months we have used ephedrine sulphate in the treatment of twenty-two cases of bronchial asthma in children. Twenty of these were taken from private practice, and two from the outpatient dispensary of the Children's Memorial Hospital. The effects of the drug were observed and reported to us in each instance by the parents. They were requested to keep a record of the dose; whether relief was afforded; if so,
Tinel's Percussion Test
Authors: Michael Scott
Journal: JAMA (1969)

ABSTRACT To the Editor:— I wish to reply to Dr. Rentschler's comments (208: 2337, 1969) concerning my modification of Tinel's percussion test for evaluating intraspinal sensory nerve root involvement (208:152, 1969).I stated that the use of Tinel's percussion test for evaluating peripheral nerve lesions was well known, and that I was suggesting a modification of this test for diagnosing involvement of any spinal sensory nerve root which innervated a cutaneous dermatomere. I chose the sixth cervical root as an example because it is frequently compressed or irritated by cervical disks or osteophytes. However, my comments concerning the manner of doing the test and its interpretation were applicable to any sensory dermatomere in the body. For example, the eighth cervical dermatomere supplying the little finger, and the mesial surface of the ring finger; the fifth thoracic dermatomere which crosses the nipple line; or the fifth lumbar dermatomere which includes the
Expression of CD133 confers malignant potential by regulating metalloproteinases in human hepatocellular carcinoma
Authors: Keisuke Kohga, Tomohide Tatsumi, Tetsuo Takehara, Hinako Tsunematsu, Satoshi Shimizu, Masashi Yamamoto, Akira Sasakawa, Takuya Miyagi, Norio Hayashi
Journal: Journal of Hepatology (2010)
ACCESSORY PROTEINS FOR G PROTEINS: Partners in Signaling
Authors: Motohiko Sato, Joe B. Blumer, Violaine Simon, Stephen M. Lanier
Journal: The Annual Review of Pharmacology and Toxicology (2005)

Accessory proteins involved in signal processing through heterotrimeric G proteins are generally defined as proteins distinct from G protein-coupled receptor (GPCR), G protein, or classical effectors that regulate the strength/efficiency/specificity of signal transfer upon receptor activation or position these entities in the right microenvironment, contributing to the formation of a functional signal transduction complex. A flurry of recent studies have implicated an additional class of accessory proteins for this system that provide signal input to heterotrimeric G proteins in the absence of a cell surface receptor, serve as alternative binding partners for G protein subunits, provide unexpected modes of G protein regulation, and have introduced additional functional roles for G proteins. This group of accessory proteins includes the recently discovered Activators of G protein Signaling (AGS) proteins identified in a functional screen for receptor-independent activators of G protein signaling as well as several proteins identified in protein interaction screens and genetic screens in model organisms. These accessory proteins may influence GDP dissociation and nucleotide exchange at the G(alpha) subunit, alter subunit interactions within heterotrimeric G(alphabetagamma) independent of nucleotide exchange, or form complexes with G(alpha) or G(betagamma) independent of the typical G(alphabetagamma) heterotrimer. AGS and related accessory proteins reveal unexpected diversity in G protein subunits as signal transducers within the cell.
Low Prevalence of Alterations in the Pancreatic Duct System in Patients with Primary Sclerosing Cholangitis
Authors: U. Schimanski, A. Stiehl, W. Stremmel, I. Theilmann
Journal: Endoscopy (1996)

Primary sclerosing cholangitis (PSC) is a rare disease of unknown origin that involves the intrahepatic or extrahepatic biliary system, or both. To obtain more precise information on concomitant involvement of the pancreatic duct system, a comparatively large group of 44 patients was studied.Between 1989 and 1995, 44 patients took part in a study of the therapeutic effect of ursodeoxycholic acid, and their data were analyzed. In 42 of the 44 patients, both the pancreatic and biliary system were visualized by endoscopic retrograde cholangiopancreatography (ERCP).Pancreas divisum was detected in four patients (9.5%) with an otherwise normal major pancreatic duct. Three (7.1%) patients had pancreatic duct changes of the type seen in chronic pancreatitis. When risk factors such as alcohol abuse were excluded, there was only one patient with PSC and pancreatic duct alterations.In PSC patients, the prevalence of chronic pancreatitis is low.
Human but not murine multipotent mesenchymal stromal cells exhibit broad-spectrum antimicrobial effector function mediated by indoleamine 2,3-dioxygenase
Authors: R Meisel, S Brockers, K Heseler, Ö Degistirici, H Bülle, C Woite, S Stuhlsatz, W Schwippert, M Jäger, R Sorg, R Henschler, J Seissler, D Dilloo, W Däubener
Journal: Leukemia (2011)
Impact of interactions of cellular components of the bone marrow microenvironment on hematopoietic stem and progenitor cell function
Authors: Brahmananda R. Chitteti, Ying-Hua Cheng, Bradley Poteat, Sonia Rodriguez-Rodriguez, W. Scott Goebel, Nadia Carlesso, Melissa A. Kacena, Edward F. Srour
Journal: Blood (2010)
Iododerma from wound irrigation with povidone-iodine
Authors: M. E. Bishop
Journal: JAMA (1978)

IODODERMA is a protean group of skin lesions that includes urticarial lesions, acneiform papules and pustules, vesicles, bullae, vegetating lesions, nodules, and tumors. It is usually induced by the ingestion of iodides such as are found in cough medicines and expectorants. This case report is unique in that pustular iododerma followed wound irrigation with 10% povidone-iodine. <h3>Report of a Case</h3> A 57-year-old man complained of a generalized pustular eruption. He had bilateral wound abscesses in the groin from a six-month-old aortal bifemoral bypass. The wounds had been incised, drained, debrided, and irrigated with 10% povidone-iodine at the rate of 100 ml/hr via intracatheters for 24 hours. The patient also began receiving oxacillin and chloramphenicol one day before the debridement. Twenty-four hours after debridement, numerous 2- to 4-mm pustules on an erythematous base appeared on the arms, face, and thighs. The lesions were especially numerous on the eyelids and beneath a
Relations between three-dimensional, volumetric experiences, and neural processes: Limitations of materialism
Authors: Axel Randrup
Journal: Behavioral and Brain Sciences (2003)

Certain features of perception – the quale red, for example, and other qualia – must be regarded as additions to the materialist neurophysiological picture of perception. The perception of three-dimensional volumetric objects can also be seen as qualitative additions to the neurophysiological processes in the brain, possibly without additions to the information content.
Optogenetics Illuminates Brain Function
Authors: Bridget M. Kuehn
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Rapidly Enlarging Nodule on the Dorsal Aspect of the Nose—Quiz Case
Authors: Iona Chapman, Brandon Litzner, Heidi Jacobe
Journal: JAMA Dermatology (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal