Carcinoembryonic Antigen Revisited
Authors: SUMNER C. KRAFT
Journal: Annals of Internal Medicine (1973)

Editorial Notes1 January 1973Carcinoembryonic Antigen RevisitedSUMNER C. KRAFT, M.D., F.A.C.P.SUMNER C. KRAFT, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-1-147 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA recent editorial in this journal (1) reviewed the relatively brief history of carcinoembryonic (CE) antigen and indicated the increasing interest in this glycoprotein and its potential importance in the diagnosis of cancer. It was mentioned that a five-center collaborative study with Dr. Phil Gold and his co-workers at Montreal General Hospital had been undertaken to determine whether their original radioimmunoassay for detecting circulating carcinoembryonic antigen (2) could be duplicated in other laboratories and to assess the diagnostic value of the test. The first results of this project have now been reported (3).Among 146 patients with proved colorectal cancer,...References1. KRAFT S: "Humors from tumors": Carcinoembryonic antigen, alpha-fetoprotein, and digestive system cancer (editorial). Ann Intern Med 76:502-504, 1972 LinkGoogle Scholar2. THOMSON D, KRUPEY J, and FREEDMAN S: The radioimmunoassay of circulating carcinoembryonic antigen of the human digestive system. Proc Natl Acad Sci USA 64:161-167, 1969 CrossrefMedlineGoogle Scholar3. : A collaborative study of a test for carcinoembryonic antigen (CEA) in the sera of patients with carcinoma of the colon and rectum. Can Med Assoc J 107:25-33, 1972 MedlineGoogle Scholar4. LO GERFO P, KRUPEY J, and HANSEN H: Demonstration of an antigen common to several varieties of neoplasia. Assay using zirconyl phosphate gel. N Engl J Med 285:138-141, 1971 CrossrefMedlineGoogle Scholar5. REYNOSO G, CHU T, and HOLYOKE D: Carcinoembryonic antigen in patients with different cancers. JAMA 220:361-365, 1972 CrossrefMedlineGoogle Scholar6. EGAN M, LAUTENSCHLEGER J, and COLIGAN J: Radioimmune assay of carcinoembryonic antigen. Immunochemistry 9:289-299, 1972 CrossrefMedlineGoogle Scholar7. GO V, SCHUTT A, and MOERTEL C: Radioimmunoassay of carcinoembryonic antigen (CEA). A modified method and a clinical evaluation (abstract). Gastroenterology 62:754, 1972 Google Scholar8. KLEINMAN M and TURNER M: Radioimmunoassay of carcinoembryonic antigen in serum of normal subjects and patients with colonic carcinoma. Gut 13:390-394, 1972 CrossrefMedlineGoogle Scholar9. RULE A, STRAUS E, and VANDEVOORDE J: Tumor-associated (CEA-reacting) antigen in patients with inflammatory bowel disease. N Engl J Med 287:24-26, 1972 CrossrefMedlineGoogle Scholar10. CHU T, REYNOSO G, and HANSEN H: Demonstration of carcinoembryonic antigen in normal human plasma. Nature (Lond) 238:152-153, 1972 CrossrefMedlineGoogle Scholar11. FREED D and TAYLOR G: Carcinoembryonic antigen in faeces. Br Med J 1:85-87, 1972 CrossrefMedlineGoogle Scholar12. MARTIN F and MARTIN M: Demonstration of antigens related to colonic cancer in the human digestive system. Int J Cancer 6:352-360, 1970 CrossrefMedlineGoogle Scholar13. DHAR P, MOORE T, and ZAMCHECK N: Carcinoembryonic antigen (CEA) in colonic cancer. Use in preoperative and postoperative diagnosis and prognosis. JAMA 221:31-35, 1972 CrossrefMedlineGoogle Scholar14. HOLLINSHEAD A, MCWRIGHT C, and ALFORD T: Separation of skin reactive intestinal cancer antigen from the carcinoembryonic antigen of Gold. Science 177:887-889, 1972 CrossrefMedlineGoogle Scholar15. KRUPEY J, WILSON T, and FREEDMAN S: The preparation of purified carcinoembryonic antigen of the human digestive system from large quantities of tumor tissue. Immunochemistry 9:617-622, 1972 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: SUMNER C. KRAFT, M.D., F.A.C.P.Affiliations: University of Chicago Chicago, Ill. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIts possible application in the management of large-bowel cancer 1 January 1973Volume 78, Issue 1 Page: 147-147 Keywords Antigens Carcinoembryonic antigen Colorectal cancer Glycoproteins Radioimmunoassays ePublished: 1 December 2008 Issue Published: 1 January 1973 PDF downloadLoading ...