Localized Atrophy of Subcutaneous Fat Following Repeated Injections of Insulin*†
Authors: FRIEDRICH ENGELBACH
Journal: Annals of Internal Medicine (1933)

Article1 April 1933Localized Atrophy of Subcutaneous Fat Following Repeated Injections of InsulinReport of a CaseFRIEDRICH ENGELBACH, M.D.FRIEDRICH ENGELBACH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-6-10-1322 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe localized atrophy of subcutaneous fat following repeated injections of insulin was first described by Depisch1 in 1926, and since then has been reported by Barborka,2 Davison,3 Mentzer and DuBray,4 Carmichal and Graham,5 Chapman,6 Rabinowitch,7,11 Lawrence,8 Priesel and Wagner,9,17 Avery,10 Fischer,12 McCormick and Moorhead,13 Stransky,14 Price,16 Boller,18 Eeg-Olofsson,19 and Williams.21 Less than sixty cases are recorded in the literature, and of these, less than half are described even briefly, and only two biopsy reports are given.The atrophy noted was almost always at sites of frequent insulin injections and began several months to several years after starting the injections of...Bibliography1 DEPISCH F: Über lokale Lipodystrophie bei lange Zeit mit Insulin behandelten Fällen von Diabetes, Klin. Wchnschr., 1926, v, 1965-1966. CrossrefGoogle Scholar2 BARBORKA CJ: Fatty atrophy from injections of insulin, Jr. Am. Med. Assoc., 1926, lxxxvii, 1646-1647. CrossrefGoogle Scholar3 DAVISON RA: Absorption of subcutaneous fat deposits at site of repeated insulin injections; report of a case, Calif. and West. Med., 1927, xxvi, 210-212. Google Scholar4 MENTZERDUBRAY SHES: Fatty atrophy from injections of insulin, Calif. and West. Med., 1927, xxvi, 212. Google Scholar5 CARMICHALGRAHAM EAG: Local fat atrophy following insulin injections, Lancet, 1928, i, 601. CrossrefGoogle Scholar6 CHAPMAN PD: Local fat atrophy following insulin injections, Lancet, 1928, i, 674. CrossrefGoogle Scholar7 RABINOWITCH IM: Atrophy of subcutaneous fat following insulin injections, Canad. Med. Assoc. Jr., 1928, xviii, 560-561. Google Scholar8 LAWRENCE RD: Effect of prolonged use of insulin on the subcutaneous tissues, Lancet, 1928, i, 1328. CrossrefGoogle Scholar9 PRIESELWAGNER RR: Über lokale Lipodystrophie nach Insulininjectionen, Ztschr. f. Kinderh., 1928, xlvi, 453-456. CrossrefGoogle Scholar10 AVERY H: Insulin fat atrophy—a traumatic atrophic panniculitis, Brit. Med. Jr., 1929, i, 597-599. CrossrefGoogle Scholar11 RABINOWITCH IM: Case of extensive atrophy of subcutaneous fat following injections of insulin, Canad. Med. Assoc. Jr., 1929, xxi, 67-68. Google Scholar12 FISCHER AE: The frequency of atrophy of the subcutaneous fat following the injection of insulin, Am. Jr. Dis. Child., 1929, xxxviii, 715-720. Google Scholar13 MCCORMICKMOORHEAD VOTG: Insulin fat atrophy, Irish Jr. Med. Sci., 1929, 727. CrossrefGoogle Scholar14 STRANSKY E: Lipodystrophie um die und fernab von den injektionstellen nach Insulinbehandlung bei Diabetes mellitus, Wien. med. Wchnschr., 1930, lxxx, 133-134. Google Scholar15 DEPISCH F: Weiterer Beitrag zur Frage der lokalen Lipodystrophie bei Dauerinsulinbehandlung, Wien. med. Wchnschr., 1930, lxxx, 168-169. Google Scholar16 PRICE LR: Local absorption of fat due to injections of insulin, Lancet, 1930, i, 1015-1016. CrossrefGoogle Scholar17 PRIESELWAGNER RR: Die Insulinlipodystrophie bei Kindern, Klin. Wchnschr., 1930, ix, 1548-1549. CrossrefGoogle Scholar18 BOLLER R: Behandlung der Insulin-Lipodystrophie, Klin. Wchnschr., 1930, ix, 2433-2435. CrossrefGoogle Scholar19 EEG-OLOFSSON R: Local changes in subcutaneous tissue following injections of insulin, Acta med. Scandinav., 1930, lxxiii, 89-98. Google Scholar20 DEPISCH F: Über lokale Lipodystrophie, Bemerkungen zur Arbeit von Priesel und Wagner "Die Insulinlipodystrophie bei Kindern", Klin. Wchnschr., 1931, x, 1174. CrossrefGoogle Scholar21 WILLIAMS JR: Case report of extensive atrophy of subcutaneous fat following repeated injections of insulin, Jr. Lab. and Clin. Med., 1931, xvi, 1191-1193. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: FRIEDRICH ENGELBACH, M.D.Affiliations: Ann Arbor, Michigan*Received for publication May 30, 1932.†From the Department of Internal Medicine, University of Michigan, Ann Arbor. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRepeatability of gastric analysisFettsucht und MagersuchtExperimental Investigations of the Hydrochloric Acid Secretion in Scorbutic Guinea-pigsÜber Lokale Lipodystrophie bei Dauer-Insulinbehandlung 1 April 1933Volume 6, Issue 10Page: 1322-1326KeywordsAtrophyBiopsyFatsInsulin ePublished: 1 December 2008 Issue Published: 1 April 1933 PDF downloadLoading ...