tbuckley/cabot-search huggingface dataset:
Movements and Forces of the Human Heart
Authors: T. R. HARRISON, JOHN A. LOWDER, LLOYD L. HEFNER, DONALD C. HARRISON
Journal: Circulation (1958)

Precordial movements starting after P and before Q have been studied. Right atrial contraction appears to cause a forward-rightward motion and left atrial contraction a backward movement of the precordium. The latter is exaggerated in most patients with mitral stenosis and in some patients with myocardial failure.
Lipid analysis of follicular casts from cyanoacrylate strips as a new method for studying therapeutic effects of antiacne agents
Authors: A. Thielitz, M. Helmdach, E-M. Ropke, H. Gollnick
Journal: British Journal of Dermatology (2001)

Journal Article Lipid analysis of follicular casts from cyanoacrylate strips as a new method for studying therapeutic effects of antiacne agents Get access A. Thielitz, A. Thielitz Department of Dermatology and Venereology, Medical Faculty, Otto von Guericke University Magdeburg, Leipziger Strasse 44, D‐39120 Magdeburg, Germany Search for other works by this author on: Oxford Academic Google Scholar M. Helmdach, M. Helmdach Department of Dermatology and Venereology, Medical Faculty, Otto von Guericke University Magdeburg, Leipziger Strasse 44, D‐39120 Magdeburg, Germany Search for other works by this author on: Oxford Academic Google Scholar E‐M. Röpke, E‐M. Röpke Department of Dermatology and Venereology, Medical Faculty, Otto von Guericke University Magdeburg, Leipziger Strasse 44, D‐39120 Magdeburg, Germany Search for other works by this author on: Oxford Academic Google Scholar H. Gollnick H. Gollnick Department of Dermatology and Venereology, Medical Faculty, Otto von Guericke University Magdeburg, Leipziger Strasse 44, D‐39120 Magdeburg, Germany Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 145, Issue 1, 1 July 2001, Pages 19–27, https://doi.org/10.1046/j.1365-2133.2001.04276.x Published: 01 July 2001
Gene Hunters Nab the Huntington's Defect; Now Tests Can Suggest Not Only If but When
Authors: Teri Randall
Journal: JAMA (1993)

HOLLYWOOD screenwriters couldn't have created a better ending to this real-life story: the genetic defect that causes Huntington's disease was so beguiling and elusive that some of the biggest names in biological research set competition aside to form an unprecedented international search party. Their task would be straightforward, or so they thought. But elegant experiments that profited other gene stalkers led only to dead ends and disappointments. Their search, they came to realize, was a long, mean endurance test in the salt mines of science, and it brought these giants to their knees before they captured their prize. Last month, their quest ended where it began, in the laboratory of James Gusella, PhD, director of the Molecular Neurogenetics Unit at Massachusetts General Hospital in Boston. The place seems particularly fitting, since it was in the same laboratory a decade earlier that Gusella's team identified the gene's ball-park location on chromosome
RESUME OF THE COMPLETE GASTRIC ANALYSES IN SIXTY-ONE CONSECUTIVE CASES OF INDIGESTION.
Authors: ALBERT WOLDERT
Journal: JAMA (1907)

I have previously reported 30 consecutive cases of indigestion which I treated in private practice, and in which complete gastric analyses were made.<sup>1</sup>I now supplement that report by adding to the list 31 new cases, thus making a total of 61 cases reported to this date. In my treatment of stomach disorders I have to a large degree followed the methods outlined by Ewald, as follows: 1, To secure a complete accurate history of each patient; 2, to determine the percentage of free hydrochloric acid; 3, to determine the percentage of total acids; 4, to determine the motor power of stomach; 5, to determine the absorptive power of stomach; 6, to determine the digestive power of gastric juice on albumin (meats); 7, to determine the digestive power of gastric juice on starch (breads); 8, to determine the presence or absence of the milk-curdling ferment (rennin); 9, to determine
Acceleration of ventricular rate by amiodarone in atrial fibrillation associated with the Wolff-Parkinson-White syndrome
Authors: B. D Sheinman, T. Evans
Journal: BMJ (1982)

Amiodarone has proved to be a valuable drug in atrial fibrillation associated with the Wolff-Parkinson-White syndrome. When it was administered to a patient with this syndrome in atrial fibrillation, who had previously suffered an inferior myocardial infarction, the ventricular rate accelerated from 170 to 230 beats/minute.This unusual case emphasises the need for full electrophysiological assessment of patients with the Wolff-Parkinson-White syndrome for whom amiodarone treatment is being considered.
Intramural Ventricular Cardiac Fibroma
Authors: ALEXANDER S. GEHA, WILLIAM H. WEIDMAN, EDWARD H. SOULE, DWIGHT C. MCGOON
Journal: Circulation (1967)

Two cases in which large intramural ventricular cardiac fibromas were successfully removed from children are reported. In one the fibroma was principally septal, and in the other it lay in the free wall of the left ventricle. These are the second and third such operations reported. A review of these two cases plus 34 other reported cases of cardiac fibroma indicates that a primary mural tumor of the heart should be suspected in patients, particularly children, with unexplained cardiac failure, unexplained cardiac dysrhythmia, intracardiac calcifications, irregular shadows on roentgenograms, or unexplained newly developing cardiac symptoms and murmurs. Angiocardiography is the best way of confirming the diagnosis. In view of the potential hazard of these tumors, their surgical removal should be undertaken, and this experience indicates that even very large and extensive intramural ventricular tumors may be removed successfully.
Electrosurgical Burn Injuries and Their Prevention
Authors: Charles G. Battig
Journal: JAMA (1968)

Electrocution hazards associated with electrical monitoring devices have recently received attention. The recurring problem of accidental electrosurgical burns has received less publicity. Most such burns are caused by faulty attachment of the patient ground plate. This plate provides a low-current-density pathway for the highfrequency cautery current. Failure of this pathway results in burns at body areas in contact with other fortuitous ground points. Battery-clamp types of connectors are most unreliable and should not be used to attach the ground plate. Built-in, ground-circuit monitors may warn of a failure in the connection to the ground plate but not of failure of contact between patient and ground plate. Especially serious burns can result from failure of the ground circuit if a patient is connected to other electrical devices in addition to the electrosurgical unit.
Contemporary Sexual Behavior: Critical Issues in the 1970s
Authors: Natalie Shainess
Journal: JAMA (1973)

<i>Contemporary Sexual Behavior</i>, the proceedings of a symposium held by the American Psychopathological Association, is a rich and varied antipasto. It leaves the reader with the sensation of having had a satisfying meal, even though it is more researchand theory-oriented than its title implies, and it may be a bit disappointing to those expecting clinical help. It is hard to do the book justice in a brief review, for the overall quality is high, and the only workable possibility is to single out a few chapters for comment. Gordon Jensen's chapter on the relation between human sexual behavior and that of primates is valuable because, while conveying much information, he is never guilty of assuming that each is a reasonable facsimile of the other. The chapter on woman's sexual arousal is somewhat disappointing because human arousal is so dependent on the social context that it does not easily lend itself
IMMEDIATE EXAMINATION OF UTERINE MUCOSA AND MYOMATOUS NODULES AFTER HYSTEROMYOMECTOMY TO EXCLUDE MALIGNANT DISEASE.
Authors: THOMAS S. CULLEN
Journal: JAMA (1906)

It has long been known that sarcomatous changes may occur in myomata. In 1860<sup>1</sup>Virchow gave a very clear account of the gross and histologic pictures in such cases. In 1872<sup>2</sup>Chrobak drew attention to this class of cases, and in 1887<sup>3</sup>Ritter gave a full survey of the literature up to that date. The question was fully discussed by Williams,<sup>4</sup>as well as by Schreher,<sup>5</sup>in 1894; and in 1895 by L. Pick.<sup>6</sup>The article of Gessner,<sup>7</sup>published in 1899, is the most exhaustive that we possess, and will well reward a thorough study. Among the more recent and lucid articles is that of Wier,<sup>8</sup>published in 1901, and that of Jacobi and Wollstein,<sup>9</sup>which appeared in 1902. But it was the excellent paper by Charles P. Noble, that first thoroughly aroused gynecologists to an appreciation of the possible danger
Short implant in limited bone volume
Authors: David Nisand, Franck Renouard
Journal: Periodontology 2000 (2014)

Abstract Rehabilitation of severely resorbed jaws with dental implants remains a surgical and prosthetic challenge for clinicians. The purpose of this review was to evaluate the available data on short‐length implants and discuss their indications and limitations in daily clinical practice. A structured review of MEDLINE and a manual search were conducted. Thirty‐two case series devoted to short‐length implants, 14 reviews and 3 randomized controlled trials were identified. Of this group of papers, we can conclude that short‐length implants can be successfully used to support single and multiple fixed reconstructions in posterior atrophied jaws, even in those with increased crown‐to‐implant ratios. The use of short‐length implants allows treatment of patients who are unable to undergo complex surgical techniques for medical, anatomic or financial reasons. Moreover, the use of short‐length implants in daily clinical practice reduces the need for complex surgeries, thus reducing morbidity, cost and treatment time. The use of short implants promotes the new concept of stress‐minimizing surgery, allowing the surgeon to focus more on the correct three‐dimensional positioning of the implant.
A major histocompatibility complex class I-related Fc receptor for IgG on rat hepatocytes.
Authors: R S Blumberg, T Koss, C M Story, D Barisani, J Polischuk, A Lipin, L Pablo, R Green, N E Simister
Journal: Journal of Clinical Investigation (1995)

Intestinal epithelial cells of the neonatal rat and mouse have been shown to express a major histocompatibility complex (MHC) class I-like Fc receptor, or FcRn, which transports IgG in an apical to basolateral direction. Previous studies have suggested the possible expression of this receptor beyond the neonatal period within the liver. Since bile contains high levels of IgG, we sought to determine whether the FcRn was functionally expressed by adult rat hepatocytes. Using primers specific for FcRn, which did not cross hybridize with MHC class I transcripts, FcRn DNA was amplified by reverse transcriptase polymerase chain reaction from RNA of adult rat hepatocytes. This RNA contained functional FcRn transcripts as it encoded a beta 2-microglobulin-associated cell surface protein as determined by immunoprecipitation of biotinylated cell surface proteins with a polyclonal anti-FcRn specific antiserum. Western blotting of hepatocyte canalicular (apical) and sinusoidal (basolateral) plasma membranes with an FcRn-specific monoclonal antibody further confirmed the protein expression and suggested that FcRn was enriched on the canalicular surface membranes. FcRn, on the surface of hepatocytes, was biologically functional as it bound Fc fragments of IgG at pH 6.0 but not 8.0, which is the same pH dependence observed for FcRn in rat neonatal enterocytes. Thus, FcRn is functionally expressed outside of the neonatal period on the canalicular cell surface of adult hepatocytes. This suggests that hepatocyte FcRn may bind luminal IgG, providing a potential functional communication between parenchymal immune cells and bile.
My most useful surgery instrument
Authors: Paul Vincent
Journal: BMJ (2004)

What could it be that really makes a difference among the clutter of my room? Perhaps the cliched badge of medical authority, the stethoscope? No, on reflection, I think not: “Mr chesty cough aged more than 60” will receive an antibiotic whatever I hear, and little “Miss croupy cough but well” will not, even if I do hear the odd crackle on a lung base. Perhaps it is the sphygmomanometer: think of all those strokes saved by judicious use of bendrofluazide. Yet again, perhaps not: “Mr ischaemic heart diseases on three antihypertensives at full dose” will have high blood pressure whatever I throw at his cardiovascular system. Perhaps then, …
Direct parametric reconstruction from undersampled (k, t)-space data in dynamic contrast enhanced MRI
Authors: Nikolaos Dikaios, Simon Arridge, Valentin Hamy, Shonit Punwani, David Atkinson
Journal: Medical Image Analysis (2014)

The Magnetic Resonance Imaging (MRI) signal can be made sensitive to functional parameters that provide information about tissues. In dynamic contrast enhanced (DCE) MRI these functional parameters are related to the microvasculature environment and the concentration changes that occur rapidly after the injection of a contrast agent. Typically DCE images are reconstructed individually and kinetic parameters are estimated by fitting a pharmacokinetic model to the time-enhancement response; these methods can be denoted as "indirect". If undersampling is present to accelerate the acquisition, techniques such as kt-FOCUSS can be employed in the reconstruction step to avoid image degradation. This paper suggests a Bayesian inference framework to estimate functional parameters directly from the measurements at high temporal resolution. The current implementation estimates pharmacokinetic parameters (related to the extended Tofts model) from undersampled (k, t)-space DCE MRI. The proposed scheme is evaluated on a simulated abdominal DCE phantom and prostate DCE data, for fully sampled, 4 and 8-fold undersampled (k, t)-space data. Direct kinetic parameters demonstrate better correspondence (up to 70% higher mutual information) to the ground truth kinetic parameters (of the simulated abdominal DCE phantom) than the ones derived from the indirect methods. For the prostate DCE data, direct kinetic parameters depict the morphology of the tumour better. To examine the impact on cancer diagnosis, a peripheral zone prostate cancer diagnostic model was employed to calculate a probability map for each method.
Gagging and duties
Authors: P. J Galea
Journal: BMJ (2010)

Jane Cassidy’s article raises several pressing questions.1 The examples given are shocking, but many of us will be aware of others. There seems to be a trend for NHS trust administrations to abuse power—with law, regulations, guidelines, agreements reached, and promises made ignored or bypassed as convenient.

Why? Firstly, because this is a way for administrators to …
Osteoporosis and Smoking
Authors: John J. Rozanski
Journal: JAMA (1972)

To the Editor.—  I wish to respond to Dr. Daniell's letter published in the July 31, 1972, issue ofThe Journalregarding the relationship between osteoporosis and smoking. In his study of 17 patients with severe idiopathic, presenile osteoporosis, 15 smoked 20 or more cigarettes per day for many years. Several possible mechanisms were discussed regarding smoking and osteoporosis. I believe another needs mentioning. As is well known, severe immobility can lead to osteoporosis. Decreased osteoblastic and increased osteoclastic activity occurs as a result of immobilization and lack of proper mechanical stress on bones. In Dr. Daniell's study, the group with idiopathic presenile osteoporosis included many subjects with severe chronic respiratory illnesses. Two of the patients died subsequently of chronic obstructive pulmonary disease. Thus, in this study, heavy smoking seems as likely to be related to osteoporosis via severe respiratory illness causing immobility as via the other mechanisms proposed to
Protective effects of the calmodulin antagonist bepridil on ischaemia induced in the rat myocardium
Authors: K. SHIKANO, M. KUSAGAWA, H. ITOH, H. HIDAKA
Journal: Cardiovascular Research (1986)

The effects of a block of the slow calcium channel by bepridil and its antagonising effects on calmodulin were determined in the ischaemic rat myocardium. When isolated rat hearts were treated with a cardioplegic solution containing bepridil or verapamil there was a significant diminution in ischaemic damage in the myocardium. Bepridil was more effective than verapamil in protecting against this ischaemic damage. Bepridil effectively inhibited the activation of calmodulin dependent enzymes, such as calcium calmodulin dependent cyclic nucleotide phosphodiesterase and myosin light chain kinase. The inhibitory effect of verapamil on these enzymes was weaker than that of bepridil. Since bepridil protects the myocardium and minimises ischaemia induced damage these events might be related to a calmodulin antagonistic action as well as a calcium channel blocking action.
Fetal abnormalities after abortion.
Authors: C B Goodhart
Journal: BMJ (1978)

Fetal abnormalities in pregnancies subsequent to spontaneous abortion do not necessarily mean that trophoblastic rests left inside the mother were responsible for the abnormalities in the next child. A miscarriage is usually a sign that something is wrong, and there is a good chance that for the very same reasons, the next pregnancy will be similarly affected, which can explain by itself the incidence of fetal abnormalities after spontaneous abortion. There is no reason at all to assume that the incidence of fetal abnormalities could rise after induced abortion, since there are no reasons to suppose that these pregnancies would have been other than normal, if not terminated. Since it is important to assess the risk of subsequent pregnancies after induced abortion, the hypothesis of trophoblastic rests should be pursued further.
Pathological basis of failure of concurrent glyceryl trinitrate therapy to improve efficacy of tissue type plasminogen activator in coronary thrombosis
Authors: F A Nicolini, W W Nichols, T G P Saldeen, J L Mehta
Journal: Cardiovascular Research (1991)

Study objective – The aim was to examine the effect of glyceryl trinitrate, a potent coronary vasodilator, on the thrombolytic effects of tissue type plasminogen inhibitor (t-PA) in dogs with coronary thrombosis.
Association Between Adoption of Evidence-Based Treatment and Survival for Patients With ST-Elevation Myocardial Infarction
Authors: Tomas Jernberg
Journal: JAMA (2011)

Only limited information is available on the speed of implementation of new evidence-based and guideline-recommended treatments and its association with survival in real life health care of patients with ST-elevation myocardial infarction (STEMI).To describe the adoption of new treatments and the related chances of short- and long-term survival in consecutive patients with STEMI in a single country over a 12-year period.The Register of Information and Knowledge about Swedish Heart Intensive Care Admission (RIKS-HIA) records baseline characteristics, treatments, and outcome of consecutive patients with acute coronary syndrome admitted to almost all hospitals in Sweden. This study includes 61,238 patients with a first-time diagnosis of STEMI between 1996 and 2007.Estimated and crude proportions of patients treated with different medications and invasive procedures and mortality over time.Of evidence-based treatments, reperfusion increased from 66% (95%, confidence interval [CI], 52%-79%) to 79% (95% CI, 69%-89%; P < .001), primary percutaneous coronary intervention from 12% (95% CI, 11%-14%) to 61% (95% CI, 45%-77%; P < .001), and revascularization from 10% (96% CI, 6%-14%) to 84% (95% CI, 73%-95%; P < .001). The use of aspirin, clopidogrel, β-blockers, statins, and angiotensin-converting enzyme (ACE) inhibitors all increased: clopidogrel from 0% to 82% (95% CI, 69%-95%; P < .001), statins from 23% (95% CI, 12%-33%) to 83% (95% CI, 75%-91%; P < .001), and ACE inhibitor or angiotensin II receptor blockers from 39% (95% CI, 26%-52%) to 69% (95% CI, 58%-70%; P < .001). The estimated in-hospital, 30-day and 1-year mortality decreased from 12.5% (95% CI, 4.3%-20.6%) to 7.2% (95% CI, 1.7%-12.6%; P < .001); from 15.0% (95% CI, 6.2%-23.7%) to 8.6% (95% CI, 2.7%-14.5%; P < .001); and from 21.0% (95% CI, 11.0%-30.9%) to 13.3% (95% CI, 6.0%-20.4%; P < .001), respectively. After adjustment, there was still a consistent trend with lower standardized mortality over the years. The 12-year survival analyses showed that the decrease of mortality was sustained over time.In a Swedish registry of patients with STEMI, between 1996 and 2007, there was an increase in the prevalence of evidence-based treatments. During this same time, there was a decrease in 30-day and 1-year mortality that was sustained during long-term follow-up.
The comparison of neuroprotective effects of intrathecal dexmedetomidine and metilprednisolone in spinal cord injury
Authors: Feyzi Celik, Cüneyt Göçmez, Kağan Kamaşak, Adnan Tufek, Abdulmenap Guzel, Orhan Tokgoz, Uğur Fırat, Osman Evliyaoğlu
Journal: International Journal of Surgery (2013)
The Detection of Heart Disease in Children
Authors: ROBERT A. MILLER, JACQUES SMITH, JEREMIAH STAMLER, BETTY HAHNEMAN, MILTON H. PAUL, IRVING ABRAMS, GERSHON HAIT, JOEL EDELMAN, JOEL WILLARD, WILLIAM STEVENS
Journal: Circulation (1962)

A mass field trial was accomplished utilizing a heart sounds tape-recording procedure to detect organic heart disease in school children. The survey involved 35,934 children, with selection of an 8.2 per cent stratified random sample of Chicago elementary public-school children, drawn from eight representative geographic-socioeconomic-racial areas of the city. Of the total base population, 33,026 (91.9 per cent) were recorded. A total of 506 children was recalled for direct auscultation, based on suspicious findings on the tape recordings. Effective detection required that the tapes be interpreted by two specially trained cardiologists. Of the 506 children scheduled for recall, 492 were actually examined; 85 were evaluated as having probable organic heart disease, and were referred for complete work-up. Definite organic heart disease was ultimately diagnosed in 64 children, of whom 48 had congenital heart disease and 16 rheumatic heart disease. The prevalence rate of organic heart disease in the stratified random sample was 2 per 1,000, 1.5 for congenital heart disease and 0.5 for rheumatic heart disease. Of the total cases, 1 per 1,000 were previously unknown; all such cases have been brought under appropriate medical management as a result of their detection. A special study of the nonrespondents (those not tape recorded) revealed a six-fold higher prevalence rate of organic heart disease in these children, compared with those surveyed. A census was also made of cardiac children in special schools for the handicapped, in hospitals, or under home care. Based on the data from the sample, the nonrespondent study, and the foregoing census, the over-all prevalence rate of organic heart disease in Chicago elementary public-school children was estimated to be 3.4 per 1,000, 2.1 for congenital heart disease and 1.3 for rheumatic heart disease. A validity study was accomplished by randomly inserting 34 cases of known organic heart disease among 2,525 children in one school. Thirty-one of these 34 cases (91.2 per cent) were detected; two of the three cases missed had aortic insufficiency with highpitched grade II murmurs. It is concluded that this tape-recording procedure is a valid, feasible, and efficient method for the detection of organic heart disease in school children.