tbuckley/cabot-search huggingface dataset:
Monocytes do not inhibit peripheral blood erythroid burst forming unit colony formation.
Authors: J M Lipton, N A Link, J Breard, P L Jackson, B J Clarke, D G Nathan
Journal: Journal of Clinical Investigation (1980)

To determine a possible role of peripheral blood monocytes in erythroid differentiation, various fractions of peripheral blood mononuclear cells were prepared from normal volunteers. The fractions contained 3-95% monocytes. These freshly prepared monocytes did not inhibit erythroid burst forming unit expression in plasma clot erythroid colony culture. Null cell preparations contaminated by up to 84% monocytes expressed erythroid burst forming unit colony formation when either T lymphocytes or T-cell conditioned medium was added. These results indicate that certain peripheral blood null cells engage the program of erythroid differentiation in the presence of T cells and erythropoietin. Monocytes do not inhibit this engagement.
RNA-Binding Protein Hur Regulates CD4+ T Cell Differentiation and Is Required for Normal IL-2 Homeostasis and Allergic Airway Inflammation
Authors: Ulus Atasoy, Patsharaporn Techasintana, Jacqueline Glascock, Suzanne Ridenhour, Joseph Magee, Matt Gubin
Journal: Journal of Allergy and Clinical Immunology (2016)
Role of p38 map kinase in glycine-induced hepatocyte resistance to hypoxic injury
Authors: Rita Carini, Elisa Alchera, Gianluca Baldanzi, Daniela Piranda, Roberta Splendore, Maria Grazia De Cesaris, Paolo Caraceni, Andrea Graziani, Emanuele Albano
Journal: Journal of Hepatology (2006)
Position-Related False-positive Renal Imaging
Authors: G MAURALIDHARA RAO, K G NAGESH, G H GURUPRAKASH
Journal: Clinical Nuclear Medicine (1980)

A case report of false-positive renal imaging due to anterior displacements of the upper pole of the left kidney with the patient in the prone position is presented. False imaging can be avoided by imaging the kidneys with the patient in the supine position and with the detector the patient.
High-resolution HLA matching in hematopoietic stem cell transplantation: a retrospective collaborative analysis
Authors: Daniel Fürst, Carlheinz Müller, Vladan Vucinic, Donald Bunjes, Wolfgang Herr, Martin Gramatzki, Rainer Schwerdtfeger, Renate Arnold, Hermann Einsele, Gerald Wulf, Michael Pfreundschuh, Bertram Glass, Hubert Schrezenmeier, Klaus Schwarz, Joannis Mytilineos
Journal: Blood (2013)
Resistance of Candida species to antifungal agents used in the treatment of onychomycosis: a review of current problems
Authors: None Evans
Journal: British Journal of Dermatology (1999)

Treatment of Candida infections with fluconazole has resulted in the emergence of drug resistance, a problem particularly apparent in HIV-infected patients. Frequently, the yeast is also cross-resistant to itraconazole and other azoles. In neutropenic patients fluconazole therapy or prophylaxis has caused overgrowth and infection by inherently less susceptible species of Candida, principally C. glabrata and C. krusei. Consequently, the use of intermittent long-term azole therapy to treat onychomycosis could result in changes in the commensal yeast flora of patients — either resistance or pathogen shift. An 'off-study' investigation undertaken in patients receiving either continuous terbinafine or intermittent itraconazole for toenail onychomycosis (L.I.ON. study1) showed no evidence of changes in the yeast species present, nor in their sensitivity to itraconazole or fluconazole. Although intermittent itraconazole seems unlikely to cause problems in this respect, the situation with regard to intermittent fluconazole therapy of onychomycosis needs further study.
Accumulation of ln-111 Labeled White Blood Cells in a Wound Dressing A Potential Cause of False-positive Results
Authors: STEPHEN G. OSWALD, RUCK DAVIDS
Journal: Clinical Nuclear Medicine (1992)

Although In-111 WBC scintigraphy is of proven usefulness in the evaluation of suspected osteomyelitis, there are pitfalls that may trap the unwary interpreter, potentially leading to false-positive interpretations. The authors describe a patient with In-111 WBC accumulation in a dressing that covered a draining skin ulcer, giving rise to focal activity overlying the site of the suspected osteomyelitis. In patients undergoing In-WBC scintigraphy who have open wounds, all dressings should be removed or changed immediately before imaging.
Gastric Tumor Discovered by Chest Radiography
Authors: A H Zalev, P A Kopplin
Journal: New England Journal of Medicine (1999)

Figure 1. An 88-year-old Japanese woman had a six-week history of black stools and fatigue. Her hemoglobin level was 6.7 g per deciliter, and a fecal occult-blood test (Hemoccult) was positive on two occasions. A chest x-ray film showed a round, soft-tissue mass (arrow in Panel A) within the gastric air bubble and no clinically significant intrathoracic abnormalities. An upper gastrointestinal series revealed a round, lobulated mass arising from the right lateral and posterior walls of the gastric fundus. A computed tomographic scan with oral and intravenous contrast medium revealed an intraluminal mass (arrow in Panel B) with a lower . . .
AIDS: a bill of rights for the surgical team?
Authors: H A F Dudley, A Sim
Journal: BMJ (1988)

Two surgeons from a London hospital propose that, because the risk of AIDS infection for surgeons is probably greater than that of the non-operating clinician or laboratory worker, any member of a surgical team should have certain rights. These include the right to insist on hepatitis-level precautions for every patient who undergoes surgery; to refuse to operate on patients known to have or to be at high risk for having human immunodeficiency virus (HIV) infection, provided that an alternative surgeon is available; to have the opportunity to disclaim high risk in themselves; to have blood withdrawn for storage against a future need to establsh HIV state; and to have possible increases in their insurance premiums debated at greater length. Members of the surgical team should also have the right to have an HIV test done at their request and to request HIV testing of any patient involved in a specific incident in which virus transmission was a possibilityThe risk of HIV infection for surgeons remains, as far as is currently known, statistically extremely small but is different from and probably greater than that of the nonoperating clinician or the lab worker. A surgeon or any member of his or her team will not wish to place the HIV positive patient at risk from inadequate care. As with the patient's right to treatment, however, the team should also have some rights, whether or not they chose to exercise them. Among these rights might be the following: 1) To insist on standards in the operating room that are adequate to give the best protection to the surgical team from the risk of cross infection. 2) To reserve the right not to operate on patients known to have HIV or who are categorized as at high risk when circumstances might be unfavorable for any member of the team, always provided that an alternative surgeon is available. 3) To have the opportunity, if they so wish, formally to disclaim high risk in themselves, though the mechanism for this will be complicated. 4) To have blood withdrawn at regular intervals for storage against a future need to establish HIV state. 5) To have blood withdrawn and possibly analyzed at the time of and subsequent to a specific incident in which virus transmission was a possibility. 6) To have an HIV assay at their own behest. 7) To have the "signing on" for work and the insurance situation debated at greater length. 8) To request--and to insist--on testing for HIV of a patient involved in an injury to a surgeon.
Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation
Authors: Svetlana Radaeva, Rui Sun, Hong-na Pan, Feng Hong, Bin Gao
Journal: Hepatology (2004)

The central role of T cell activation in hepatocellular injury has been well documented. In this article, we provide evidence suggesting that T cells may also play a protective role in liver disease by releasing interleukin-22 (IL-22), a recently identified T cell-derived cytokine whose biological significance is unclear. IL-22 messenger RNA and protein expression are significantly elevated in T cell-mediated hepatitis induced by concanavalin A (ConA) but are less extensively elevated in the carbon tetrachloride-induced liver injury model. Activated CD3(+) T cells are likely responsible for the production of IL-22 in the liver after injection of ConA. The IL-22 receptor is normally expressed at high levels by hepatocytes and further induced after ConA injection. IL-22 blockade with a neutralizing antibody reduces signal transducer and activator of transcription factor 3 (STAT3) activation and worsens liver injury in T cell-mediated hepatitis, whereas injection of recombinant IL-22 attenuates such injury. In vitro treatment with recombinant IL-22 or overexpression of IL-22 promotes cell growth and survival in human hepatocellular carcinoma HepG2 cells. Stable overexpression of IL-22 in HepG2 cells constitutively activates STAT3 and induces expression of a variety of antiapoptotic (e.g., Bcl-2, Bcl-xL, Mcl-1) and mitogenic (e.g., c-myc, cyclin D1, Rb2, CDK4) proteins. Blocking STAT3 activation abolishes the antiapoptotic and mitogenic actions of IL-22 in hepatic cells. In conclusion, the T cell-derived cytokine IL-22 is a survival factor for hepatocytes; this suggests that T cell activation may also prevent and repair liver injury by releasing hepatoprotective cytokine IL-22 in addition to its previously documented central role in hepatocellular injury.
A CERTAIN CLASS OF OBSTETRIC CASES IN WHICH THE USE OF FORCEPS IS IMPERATIVELY DEMANDED.Read in the Section of Obstetrics and Diseases of Women, at the Forty-second Annual Meeting of the American Medical Association, Washington, D. C., May 5, 1891.
Authors: AUGUSTUS P. CLARKE
Journal: JAMA (1891)

Among obstetricians there is a conviction deepening more and more by experience, that whenever a preference is to be made between the use of forceps and a resort to internal version, the forceps should be chosen. The danger will be much less not only to the child but also to the mother. The risk that the child be born asphyxiated, and often, the difficulty if not impossibility of establishing artificial respiration, when internal version is had recourse to, are admitted by all accoucheurs. Even when in that class of cases in which there is much deformity, or unusual narrowness of the pelvis, the forceps is safer than version. In offering this statement, in favor of the choice of forceps, it is not on the ground that greater skill is required in the management by version, but because statistical reports of the masters of almost every country show that great
REVERSAL AGENTS IN NONVALVULAR ATRIAL FIBRILLATION PATIENTS HOSPITALIZED FOR BLEEDING: A REAL-WORLD ANALYSIS
Authors: Scott Robinson, Bruce D. Bowdy, Yonghua Jing, Robyn Schaiff, Veronica Lee, Ellen McMahon, Bernadette H. Johnson, Daniel Wiederkehr
Journal: Journal of the American College of Cardiology (2014)
F-18 FDG PET/CT Findings in Two Patients With Hepatic Angiomyolipoma With and Without Intratumoral Hemorrhage
Authors: Kentaro Takanami, Tomohiro Kaneta, Shin Hitachi, Takayuki Yamada, Kazuyuki Ishida, Toshiki Rikiyama, Yu Katayose, Michiaki Unno, Shogo Yamada, Shoki Takahashi
Journal: Clinical Nuclear Medicine (2009)

Two female patients aged 62 and 74 years underwent F-18 FDG PET/CT for evaluation of a large hepatic tumor. Subsequently, both patients underwent a partial hepatectomy which histopathologically revealed benign hepatic angiomyolipomas (AMLs). One patient with AML with a massive intratumoral hemorrhage presented with multiple foci demonstrating an increased FDG uptake along the margin of the cold defects that corresponded to low density areas within the tumor on contrast-enhanced CT, whereas the other patient with AML without any hemorrhage presented with a low FDG uptake in the tumor. This report demonstrates that benign hepatic AMLs may demonstrate increased FDG uptake if there is hemorrhage and a related inflammatory response.
Evaluation of antiarrhythmic drug effects with simultaneous analysis of single ventricular premature contractions, couplets and salvos
Authors: Georg Schmidt, Kurt Ulm, Petra Barthel, Andrea Riemenschneider, August Linzmaier, Liselotte Goedel-Meinen, Wolfgang Baedeker, Hans Blömer
Journal: Journal of the American College of Cardiology (1991)
IMMUNOLOGICAL REACTIONS WITH A VIRUS CAUSING PAPILLOMAS IN RABBITS
Authors: John G. Kidd
Journal: The Journal of Experimental Medicine (1938)

A study has been made of the yield of virus and of the complement-binding antigen from the virus-induced papillomas of cottontail and domestic rabbits. Extracts of the discrete, naturally occurring papillomas of cottontail rabbits usually contain virus in large amount; and, as a rule, they also contain the complement-binding antigen in high titer. The confluent growths produced experimentally with the virus in some cottontails, on the other hand, often fail to yield the virus, or furnish it in small amount; and extracts of them have little if any complement-binding capacity. The sera of cottontails with massive papillomas from which the virus cannot be recovered often have high antibody titers. Many extracts were tested of the virus-induced papillomas of domestic rabbits. None contained the virus in large amount, and the majority of them failed to manifest it on sensitive test. A few fixed complement in low titer when mixed with immune sera, but most failed to do so. Crude extracts of the "non-infectious," virus-induced papillomas of domestic rabbits stimulated the formation of virus-neutralizing and complement-binding antibodies in low titer when injected intraperitoneally into normal rabbits of the same breed, but Berkefeld filtrates of the same materials proved devoid of this immunizing effect. The significance of the findings described in the three papers is discussed. The evidence as a whole favors the view that the virus stimulates the formation of the virus-neutralizing and complement-binding antibodies in vivo, and many facts indicate that it is closely associated, and in all probability identical, with the antigen that reacts with immune serum to fix complement in vitro.
BIMR gastroenterology: vol 2 Small intestine
Authors: M S Losowsky
Journal: Gut (1983)

anatomy and physiology; while it may be argued that this collection of essays is aimed at clinicians, it must also be remembered that it is basic science which describes the systems which are disordered by disease and, hence, the possibilities of therapy.Although this volume embodies a scientific approach that is neither truly contemporary nor systematic, the disorders which are reviewed here are still with us, and there is much material here which will prove useful and stimulating for the clinician.As with other volumes in this series, the standard of production is high and the price is relatively low.With the proviso, that an understanding of the present state of the art will require additional reading, this collection of essays is recommended.
Money, Fun, and Angioplasty
Authors: Pascal Nicod, Urs Scherrer
Journal: Annals of Internal Medicine (1992)

Letters1 May 1992Money, Fun, and AngioplastyPascal Nicod, MD, Urs Scherrer, MDPascal Nicod, MDSearch for more papers by this author, Urs Scherrer, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-116-9-779_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors:Grüntzig's landmark report (1) of his early experience with coronary angioplasty in 50 patients with coronary artery disease has triggered the explosive growth of an entirely new field, interventional cardiology. Ten years later, more than 300 000 coronary angioplasties were done in the United States alone, contributing enormously to exponential growth in health care costs. The popularity of angioplasty is puzzling, given the high restenosis rate (2) and the absence of controlled trials comparing angioplasty with coronary artery surgery or medical treatment (3). We suggest that the combination of three factors, never so closely associated before in...References1. GrüntzigSenningSlegenthaier AAW. Nonoperative dilatation of coronary-artery stenosis. N Engl J Med. 1979;301:61-8. CrossrefMedlineGoogle Scholar2. Block P. Restenosis after percutaneous transluminal coronary angioplasty. Anatomic and pathophysiological mechanisms. Strategies for prevention. Circulation. 1990;81(Suppl IV):2-4. Google Scholar3. Kent K. New frontiers in interventional cardiology. Circulation. 1990;81(Suppl IV):1-116. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: CHUV Lausanne 1011 Switzerland PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByExperimental therapeutics and clinical studies in (Re)stenosisExplosive growth of coronary angioplasty. Success story of a less than perfect procedure. 1 May 1992Volume 116, Issue 9Page: 779-779KeywordsAngioplastyCoronary angioplastyCoronary arteriesHealth careInterventional cardiologyStable coronary artery diseaseSurgery Issue Published: 1 May 1992 PDF DownloadLoading ...
EXPERIMENTAL URIC ACID NEPHRITIS IN THE RABBIT
Authors: Joseph F. Smith, Yin Chen Lee
Journal: The Journal of Experimental Medicine (1957)

Experimental uric acid lesions in the kidney of the rabbit have been reinvestigated using the technique of miscrodissection for location of lesions. The maximal initial lesion was found to occur in the first part of the collecting, and not in the ascending Henle and the distal convoluted tubule. Such lesions were only produced by very high dosage (approximately 0.5-1 gm. per kg.). It was concluded that the argument by analogy with the uric acid lesion cannot be used to support a hypothetical toxic damage to the segments of ascending Henle and the distal convolution in the crush syndrome.
Rufus of Ephesus
Authors: D. A. Berberian
Journal: JAMA (1961)

<h3>To the Editor:—</h3> In your editorial of Dec. 17, 1960, page 2070, entitled "Rufus of Ephesus," the statement "Rufus described filariasis," should read, "Rufus described<i>dracontiasis</i>" or "<i>dracunculosis</i>," for the reference, "In the country of the Arabs there occurs an ailment, the 'snake' disease, which in Greek is called a 'sinew.' This 'snake,' as thick as the chord of a lyre, moves and turns about in the flesh like a reptile, and especially in the thighs and legs, but also in other parts of the body," refers to nothing other than the guinea worm,<i>Dracunculus medinensis</i>(medina worm, serpent worm, or dragon worm). Although the guinea worm is a tissueinhabiting nematode it does not belong to the group of round worms commonly known as filarial worms (Superfamily<i>Filarioidea</i>).
Impaired APC cofactor activity of factor V plays a major role in the APC resistance associated with the factor V Leiden (R506Q) and R2 (H1299R) mutations
Authors: Elisabetta Castoldi, Jeroen M. Brugge, Gerry A. F. Nicolaes, Domenico Girelli, Guido Tans, Jan Rosing
Journal: Blood (2004)
Regular exercise, hormone replacement therapy and the age-related decline in carotid arterial compliance in healthy women
Authors: K Moreau
Journal: Cardiovascular Research (2003)

Objective: Carotid arterial compliance is reduced with age in sedentary estrogen-deficient women, contributing to the development of cardiovascular disorders. We determined the effects of regular aerobic exercise, hormone replacement therapy (HRT), and their interaction on carotid arterial compliance using a combination of cross-sectional and intervention study designs. Methods: Cross-sectionally, we studied three groups of healthy postmenopausal women (50–80 years): 20 sedentary not taking HRT; 24 sedentary taking HRT; and 14 endurance-trained not taking HRT; and 11 sedentary premenopausal controls (20–37 years). In the intervention study, 12 sedentary postmenopausal women (58±3 years) who were taking HRT were studied before and after participation in a 3-month aerobic exercise (walking) program. Carotid arterial compliance was measured via simultaneous common carotid artery ultrasound imaging and applanation tonometry. Results: Cross-sectional study. Carotid arterial compliance was lower (P<0.001) in all three postmenopausal groups compared with premenopausal women. Among the postmenopausal groups, arterial compliance was 33–43% higher in the sedentary HRT and endurance-trained women than in their sedentary estrogen-deficient peers. Intervention study. Arterial compliance increased (P<0.05) by ∼40% to levels that were no longer different than premenopausal women. Conclusions: HRT use and regular aerobic exercise are associated with augmented carotid arterial compliance in healthy postmenopausal women. Moderate, short-term aerobic exercise can restore carotid arterial compliance in previously sedentary postmenopausal women taking HRT.
A CYTOCHEMICAL STUDY OF THE L.E. BODIES OF SYSTEMIC LUPUS ERYTHEMATOSUS
Authors: Gabriel C. Godman, Arline D. Deitch
Journal: The Journal of Experimental Medicine (1957)

Microspectrophotometric comparison of lymphocyte nuclei and free L.E. bodies which are derived from them show a more than twofold average increase in the latter of protein basic groups revealed by naphthol yellow S binding, and tyrosine residues demonstrated by the Millon reaction. The alkaline fast green method for histones and the Sakaguchi reaction for arginine residues suggest that there is a marked loss and ultimate disappearance of histones in the course of formation of the L.E. body from a nucleus. It is postulated that the L.E. transformation entails influx of protein normally foreign to the nucleus, displacement of histone from combination of DNA, and association of the DNA with the new protein which is then responsible for masking the anionic groups of DNA.
Relationship Between Asking an Older Adult About Falls and Surgical Outcomes
Authors: Teresa S. Jones, Christina L. Dunn, Daniel S. Wu, Joseph C. Cleveland, Deidre Kile, Thomas N. Robinson
Journal: JAMA Surgery (2013)

More than one-third of all US inpatient operations are performed on patients aged 65 years and older. Existing preoperative risk assessment strategies are not adequate to meet the needs of the aging population.To evaluate the relationship of a history of falls (a geriatric syndrome) to postoperative outcomes in older adults undergoing major elective operations.This prospective, cohort study was conducted at a referral medical center. Persons aged 65 years and older undergoing elective colorectal and cardiac operations were enrolled. The predictor variable was having fallen in the 6 months prior to the operation.Postoperative outcomes measured included 30-day complications, the need for discharge institutionalization, and 30-day readmission.There were 235 subjects with a mean (SD) age of 74 (6) years. Preoperative falls occurred in 33%. One or more postoperative complications occurred more frequently in the group with prior falls compared with the nonfallers following both colorectal (59% vs 25%; P = .004) and cardiac (39% vs 15%; P = .002) operations. These findings were independent of advancing chronologic age. The need for discharge to an institutional care facility occurred more frequently in the group that had fallen in comparison with the nonfallers in both the colorectal (52% vs 6%; P < .001) and cardiac (62% vs 32%; P = .001) groups. Similarly, 30-day readmission was higher in the group with prior falls following both colorectal (P = .04) and cardiac (P = .02) operations.A history of 1 or more falls in the 6 months prior to an operation forecasts increased postoperative complications, the need for discharge institutionalization, and 30-day readmission across surgical specialties. Using a history of prior falls in preoperative risk assessment for an older adult represents a shift from current preoperative assessment strategies.