tbuckley/cabot-search huggingface dataset:
BILATERAL DISEASE OF THE INTERNAL CUNEIFORM BONE WITH AN ASSOCIATED DISEASE OF THE RIGHT SCAPHOID BONE (KÖHLER'S)
Authors: Edward J. Haboush
Journal: JAMA (1933)

In recent years considerable interest has centered around a certain group of closely related disorders of bone. These are Legg-Perthes' disease of the femoral capital epiphysis, Köhler's disease of the tarsal scaphoid, Osgood-Schlatter's disease involving the epiphysis of the tibial tubercle, Kienböch's disease affecting the semilunar bone in the wrist, and Freiberg's infraction of the second metatarsal head. Most authors are of the opinion that the underlying pathologic condition in these bone disorders is microscopically an aseptic necrosis. Some authorities have observed an infiltration of the bone with fibrous tissue extending from the periosteum. Others have found cystic formation with fibrous tissue infiltration, and some report the changes of an osteochondritis. I believe that the condition which I present has heretofore been undescribed, as a careful search of the literature has failed to reveal any case with similar pathologic changes. This is a case of bilateral disease of the internal
STUDIES ON ANEMIA IN F1 HYBRID MICE INJECTED WITH PARENTAL STRAIN LYMPHOID CELLS
Authors: Eileen Harriss, Cicely Currie, Joseph P. Kriss, Henry S. Kaplan
Journal: The Journal of Experimental Medicine (1961)

The survival of (51)Cr-labeled erythrocytes has been studied in F(1) hybrid mice in which wasting disease was produced by injection of parental lymphoid cells taken either from lymph nodes and thymus or from the spleen. Coincident with the development of the disease syndrome, there occurred a severe anemia accompanied by a sudden loss of circulating labeled erythrocytes, whether host or parental. This finding suggests that the anemia is not due solely to specific immunologic reaction of donor tissue against host erythrocytes.
ANTIGENIC STRUCTURE OF CELL SURFACES
Authors: Tadao Aoki, Ulrich Hämmerling, Etienne de Harven, Edward A. Boyse, Lloyd J. Old
Journal: The Journal of Experimental Medicine (1969)

The representation of mouse alloantigens belonging to three systems, H-2, theta and TL, on the surface of cells from thymus, spleen, lymph nodes, and peritoneal cavity, was studied by electron microscopy with ferritin-labeled antibody. As expected from earlier serological data, TL was confined to thymocytes, theta was found on thymocytes and lymphocytes, and H-2 occurred to some extent on all cell types observed. On reticular cells, lymphocytes, plasma cells, and eosinophils, the majority of the cell surface was occupied by H-2; thymocytes had considerably less H-2, and erythrocytes and peritoneal macrophages least of all. In every instance the representation of antigen was discontinuous, the fraction of the cell surface covered being characteristic both of the antigen and of the type of cell. H-2 and theta provide a striking example of this; H-2 is present in far higher amounts on lymphocytes than on thymocytes, whereas the converse is true of theta. Within areas positive for H-2 or theta, protuberances of the surface membrane were often antigen-negative. A better definition of cell surface structure, gained from studies such as this, is necessary for further inquiry into how the cell surface is assembled, and into selective gene action in relation to cellular differentiation.
The Pathogenesis of Saturnine Gout: Urate Kinetic Studies.
Authors: Gene V. Ball
Journal: Annals of Internal Medicine (1968)

s1 May 1968The Pathogenesis of Saturnine Gout: Urate Kinetic Studies.Gene V. Ball, M.D., Leif B. Sorensen, M.D.Gene V. Ball, M.D.Search for more papers by this author, Leif B. Sorensen, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-5-1187_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHyperuricemia and gout have been recognized A for several centuries as complications of chronic lead ingestion. Hyperuricemia and gout have been attributed to the mild hemolytic anemia, which is part of the syndrome, and to renal retention of urate even though gout secondary to most chronic renal disease is rare.Three negro males representative of a group of more than 20 patients with lead poisoning were studied. These patients admitted to prolonged and excessive ingestion of homemade alcohol. This illegal alcohol is commonly contaminated with lead, in amounts up to 200,000 µg/liter. Chronic lead ingestion was verified by grossly elevated... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, Illinois PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1968Volume 68, Issue 5Page: 1187-1187KeywordsAlcoholsGoutHemolytic anemiaIngestionPathogenesisPatient advocacyRenal diseasesUric acid Issue Published: 1 May 1968 PDF DownloadLoading ...
THE USE OF PERPHENAZINE IN THE TREATMENT OF DRUG RESISTANT SCHIZOPHRENICS
Authors: PETER ILLBERG
Journal: American Journal of Psychiatry (1964)

In summary, we feel that perphenazine is a noteworthy means for treating most psychoses. To us, it is not just another tranquilizer. In our experience, it is obviously a most effective drug which often produces results where other therapies have miserably failed. The extent of improvement depends a great deal, however, on how the drug is used. The treatment must be individualized and requires care and thought. The drug appears to be faster acting at doses lower than that required with other phenothiazines. This study has been but a pilot investigation, but from our limited experience, we would rate the drug as highly effective in modifying behavior, attitudes, accelerating mentation, promoting awareness of self, environment, development of insight and most important, this drug is very effective in reintegrating the personality structure of the individual to normalcy.
Explicit Incestuous Motifs in Psychosomatic Patients
Authors: Harold Levitan
Journal: Psychotherapy and Psychosomatics (1982)

In this study, which is the first ever to deal with the issue of incestuous motifs in psychosomatic patients, the author reviewed the charts of all his psychosomatic patients, seen in at least 40 interviews between 1975 and 1980, and the charts of all his non-psychosomatic patients, seen in at least 40 interviews between 1970 and 1975, in order to determine the frequency of explicit incestuous motifs in each group. It was found that the motifs had been reported by more psychosomatic patients than non-psychosomatic patients. Also, it was found that the explicit incestuous motifs which had been reported by the psychosomatic patients were more intense and pervasive than those which had been reported by the non-psychosomatic patients. These findings are discussed with reference to the issue of failure of the ego's defense mechanisms in psychosomatic patients.
Hemorrhage from a Benign Ulcer of the Sigmoid Colon
Authors: William Riley Bosien, Walter B. Crandell
Journal: New England Journal of Medicine (1954)

A SOLITARY benign ulcer occurring in the large intestine with no apparent etiologic source was first described by Cruveilhier1 in 1830. Since then 83 cases of this type have been reported.2 3 4 5 6 7 8 9 Such a lesion has frequently been referred to as a "simple ulcer" of the colon.Of these 83 cases at least 53 were diagnosed after the ulcer had perforated. The majority of those that perforated had a fatal outcome. In many of the 30 cases that did not perforate the diagnosis was made at autopsy. Sixty-two of the ulcers were located in the cecum or ascending colon. Of the . . .
Neighborhood Deprivation and Change in BMI Among Adults With Type 2 Diabetes
Authors: Pamela J. Stoddard, Barbara A. Laraia, E. Margaret Warton, Howard H. Moffet, Nancy E. Adler, Dean Schillinger, Andrew J. Karter
Journal: Diabetes Care (2012)

To compare associations between neighborhood deprivation and measures of BMI change among adults with type 2 diabetes.Using data from the Kaiser Permanente Diabetes Study of Northern California (DISTANCE) survey, we estimated the association between neighborhood deprivation and two measures of BMI change over 3 years: 1) a continuous measure and 2) a categorical measure of clinically substantive BMI loss or gain (≥7% of baseline BMI) versus stable BMI. The sample included 13,609 adults.On average, there was little change in BMI (-0.12, SD 3.07); 17.0 and 16.1% had clinically substantive BMI loss or gain, respectively, at follow-up. There was a positive association between neighborhood deprivation and BMI change for adults in the most versus least-deprived quartile of neighborhood deprivation (β = 0.22, P = 0.02) in adjusted models. In addition, relative to the least-deprived quartile (Q1), adults in more-deprived quartiles of neighborhood deprivation were more likely to experience either substantive BMI loss (Q2 relative risk ratio 1.19, 95% CI 1.00-1.41; Q3 1.20, 1.02-1.42; Q4 1.30, 1.08-1.55) or gain (Q2 1.25, 1.04-1.49; Q3 1.24, 1.04-1.49; Q4 1.45, 1.20-1.75).Greater neighborhood deprivation was positively associated with BMI change among adults with diabetes as well as with clinically substantive BMI loss or gain. Findings stress the importance of allowing for simultaneous associations with both gain and loss in future longitudinal studies of neighborhood deprivation and weight change, which may be particularly true for studies of patients with diabetes for whom both weight loss and gain have health implications.
Continuing confusion over the eponymous possessive
Authors: A. D Carothers
Journal: BMJ (1995)

examine a woman who had been involved in a vehicle accident on her way to the airport.The accident was sufficiently violent to have fractured a long bone.Despite having "attended an advanced trauma and life support course" he failed to examine the patient properly-on his own admission he did not carry out a full primary survey of the patient at the outset.Nor did he insist that the patient be transferred from the plane for a proper evaluation, which would have been simple and taken only a few minutes.Admittedly, the "Heath Robinson" chest tube drainage that he performed during the flight was ingenious, but what if she had had a ruptured liver or spleen?His Sellotape and coat hanger would not have helped then.Surely the best way of managing an in flight emergency is to avoid it if at all possible.
Child With Ataxia Telangiectasia Developing Acute Myeloid Leukemia
Authors: Chien-Heng Lin, Wei-Ching Lin, Chung-Hsing Wang, Yung-Jen Ho, I-Ping Chiang, Ching-Tien Peng, Kang-Hsi Wu
Journal: Journal of Clinical Oncology (2010)

An 11-year-old boy, who was diagnosed as having ataxia telangiectasia (AT) at 5 years of age, was referred to our hospital because of a right submandibular progressive enlarged mass for 2 months.He also suffered from being unstable to stand and recently had twisting of the trunk and tremor in all areas of his body.On physical examination, the patient looked pale and had multiple cervical lymphadenopathies and telangiectasia of the bulbar conjunctiva.His gums easily bled, and he had mild gingival hypertrophy.No hepatosplenomegaly or mucocutaneous petechiae were noted.Neurologic examination revealed nystagmus, squint, dysarthric speech, diminished reflexes, dysmetria, and ataxic gait.Laboratory investigations showed leukocytosis, anemia, and thrombocytopenia (WBC count ϭ 28,500/L; platelets ϭ 59,000/ L; hemoglobin ϭ 5.2 g/L; hematocrit ϭ 27.5%).Biochemistry tests revealed ALT of 27 U/L, AST of 29 U/L, blood urea nitrogen of 9 mg/dL, creatinine of 0.5 mg/dL, and lactate dehydrogenase of 352 U/L.The ␣-fetoprotein level was high (242 ng/mL).There were decreased levels of immunoglobulin (Ig) A (6.67 mg/dL) and IgE (Ͻ 0.1 mg/dL).Electrophysiologic study showed mild to moderate motorpredominant spinal motor pathology with sensory involvement.Brain magnetic resonance images revealed isolated cerebellar atrophy with small size of vermis (Fig 1).The ventricles were all normal.Analysis of the ATM gene revealed compound heterozygous mutation (2413 C to T, arg805ter; 1402-3 del AA, lys468fs).Bone marrow examination showed hypercellularity with an excess of blastic cells (80% to 85%) with primitive nuclear morphology, little cytoplasm, easily discernible nucleoli, and distinct nuclear membrane and markedly depleted hematopoietic cells (Fig 2).These blasts were positive in peroxidase stain (Fig 3) but negative in periodic acid-Schiff stain.Flow cytometric analysis of the bone marrow aspirate revealed the following: CD13, 42.51%; CD33, 77.33%; CD34, 43.64%; HLA-DR, 34.71%; and negative for B-and T-cell markers.The karyotype of the bone marrow cells was 45,XY, Ϫ7, ϩ10,t(12;14)(p11.2;q32),Ϫ14, Ϫ22.Acute myeloid leukemia (AML) was diagnosed.After AML was diagnosed, the patient received chemotherapy according to the Taiwan Pediatric Oncology Group AML-97A protocol. 1Induction treatment consisted of cytarabine (100 mg/m 2 , continuous infusion, days 1 to 7) and idarubicin (9 mg/m 2 , intravenous push, days 1 to 3).Intrathecal methotrexate (15 mg) was administered on day 1.However, the patient did not achieve remission after two courses of induction therapy and consequently died as a result of severe pneumonia.
Evaluation of Early and Late Toxicities in Chemoradiation Trials
Authors: Søren M. Bentzen, Andrea Trotti
Journal: Journal of Clinical Oncology (2007)

Combined chemoradiotherapy is increasingly becoming a standard of care for the nonoperative management of a variety of solid malignancies. A string of randomized controlled phase III trials have shown statistically significant and clinically relevant improvements in outcome, ostensibly without any apparent increase in late toxicity. However, the reliability and the sensitivity of toxicity reporting in most trials are questionable. Audits and phase IV studies suggest that the chemoradiotherapy success comes at a price in terms of late toxicity. This review presents some of the challenges in recording, analyzing, and reporting toxicity data. Methods for summarizing toxicity are reviewed, and a new investigational metric, the TAME reporting system, is discussed. The need for special vigilance in the era of molecular-targeted agents is emphasized because of the possibility that unexpected serious adverse events with a low incidence may occur. Finally, we discuss how progress in molecular pathology and radiation biology may provide novel opportunities for stratifying patients according to risk of adverse effects, interventional targets for reducing or treating adverse effects, and surrogate markers of normal-tissue injury.
Health secretary scraps funding for survey of British attitudes to NHS
Authors: N. Timmins
Journal: BMJ (2011)

The Department of Health for England has scrapped its funding for the British social attitudes survey—the long running annual snapshot of people’s attitudes to a huge range of social issues, including the public’s willingness to fund and its levels of satisfaction with the NHS.

At the same time Andrew Lansley, the health secretary, has to decide whether to let the NHS Information Centre go ahead with its plans to cease, with immediate effect, its £300 000 (€340 000; $480 000) a year contribution to the Great Britain general lifestyle survey, a key source of information on smoking and drinking, health conditions, and the public’s use of health services.

The Information Centre’s …
Insulin improves heart function and metabolism during non-ischemic cardiogenic shock in awake canines
Authors: Jeffrey A Kline, Richard M Raymond, Elena D. Leonova, Thomas C Williams, John A Watts
Journal: Cardiovascular Research (1997)

Objectives: This study was undertaken to examine in-situ heart function and metabolism during insulin treatment of verapamil-induced cardiogenic shock in awake canines. Methods: Twenty mongrel canines were instrumented to monitor myocardial substrate uptakes (glucose, lactate, free fatty acids, oxygen [MVO2]), as well as left ventricular (LV) end-systolic elastance (Emax), LV efficiency (LV minute work/MVO2), and Tau. Shock was induced by graded intraportal verapamil infusion followed by randomized assignment to one of 4 treatment groups: saline control (3.0 ml/kg/min, n=5), epinephrine (5 μg/kg/min, n=5), glucagon (10 μg/kg/min, n=5) or insulin (1000 mU/min, n=5) with dextrose to clamp arterial [glucose] ±10% of basal concentrations. Results: Insulin treatment significantly increased Emax (34±3 vs. 17±3 mmHg/mm, saline control), and shortened Tau (9±3 ms) compared to saline control (42±5 ms), epinephrine (20±4 ms) and glucagon (35±8 ms). With insulin treatment, mechanical efficiency increased to 20 097±2070 vs. 12 424±1615 mmHg·mm/ml O2/100 g in controls. Simultaneously, insulin increased myocardial lactate uptake (35±2 vs. 17±4 μmol/min/100 g, saline control), but did not increase glucose uptake. Epinephrine and glucagon decreased mechanical efficiency compared to saline controls, coincident with increased myocardial fatty acid consumption, but without increasing lactate uptake. One dog died early with glucagon treatment before the first death in the saline-treated group. Conclusions: Insulin improves systolic and diastolic heart function during aerobic shock and accelerates in-vivo myocardial lactate oxidation.
Review of Sonia Shah.<i>The Body Hunters: How the Drug Industry Tests its Products on the World's Poorest Patients</i><sup>1</sup>
Authors: Jennifer S. Bard
Journal: The American Journal of Bioethics (2008)

"Review of Sonia Shah. The Body Hunters: How the Drug Industry Tests its Products on the World's Poorest Patients 1 ." , 8(2), pp. 52–53 Notes 1. New York, NY, The New Press, $24.95.
A New Method of Performing Plastic Operations
Authors: J. R. Wolfe
Journal: BMJ (1875)

In two hours after I left her, and six hours after the removal of the placenta, she again complained of pains, and I was again sent for.On my arrival, I found the head of the third child at the perinmeum.This was also a female, but a much stronger child than any of its predecessors, weighing ovcr seven pounds; the combined weight of all the three being over twenty pounds.After the separation of the placenta, the tumours were now about equal in size, and (juite distinct the one from the other, neither of the two occupying a middle positioin, but each taking its own side.I examined my patient lately, and I found that the external os was single, the opening very muclh elongated from side to side; but, upon tilting it forward, the (lividing septum was distinctly seen.I also intro- duced an uterine souind inito each cavity.The septum could also be felt by the introduction of the finger.This case may onily be interesting in an anatomical point of view, as there was little skill or dexterity in manipulation required during the confinement; but, as such cases are rare, I concluded that the case would not be altogether void of interest to the members of the Associa- tioin.
Psychiatry and the Primary Care Physician
Authors: Richard L. Goldberg
Journal: JAMA (1976)

Psychiatry makes an important contribution to the training and practice of primary care physicians by emphasizing a holistic approach to patient care, by teaching psychiatric skills and by providing knowledge that enables primary care physicians to give basic psychological care to the large numbers of their patients who need it. Consultation-liaison psychiatry and psychiatry education programs for medical students, both of which are given high priority for support by the Psychiatry Education Branch of National Institute of Mental Health (NIMH), are model settings in which to teach the psychiatric aspects of primary care. (<i>JAMA</i>236:944-945, 1976)
Abstract 4458: PDLIM2 is essential for feedback regulation of the B1 integrin-FAK-RhoA signalling pathway to maintain epithelial cell polarity and suppress transformation
Authors: Ravi Kiran-Deevi, Orla T. Cox, Rosemary O'Connor
Journal: Cancer Research (2014)

Abstract PDLIM2 is a PDZ-LIM domain protein that regulates the stability of transcription factors (NFkB and STATs) in the nucleus. It is also associated with the cytoskeleton at cell adhesions and cell junctions and is required for polarized cell migration. PDLIM2 expression is suppressed by methylation in different cancers, but is strongly expressed in invasive breast cancer cells that have undergone an Epithelial Mesenchymal Transition (EMT). Moreover, PDLIM2 expression is associated with poor outcome in basal breast cancers and its expression can be enhanced by vitamin D-induced differentiation of breast cancer cells. Since PDLIM2 expression repression may facilitate oncogenic transformation and its expression is modulated by the differentiation status of breast cancer cells we asked whether it is essential for maintaining a non-transformed epithelial phenotype. To address this we suppressed PDLIM2 in MCF10A cells and assessed the phenotype and mechanism in 3D Matrigel cultures. We found that PDLIM2 suppression is sufficient to disrupt cell polarization and acinar formation in Matrigel cultures. MCF10A cells with suppressed PDLIM2 formed spheres of proliferating cells that exhibited reduced apoptosis in the luminal space, compared to control acini with hollow or apoptotic lumina. Spheroids with suppressed PDLIM2 had increased expression of cell-cell adhesion proteins including E cadherin and β-catenin. Proteins associated with cell-matrix adhesion were also up-regulated, including activated beta 1 (β1) integrin, laminin, and fibronectin production. Interestingly, both the IGF-1 Receptor and RACK1, which scaffolds IGF-1R to β1 integrin, were increased, indicating a transformed phenotype. FAK and cofilin phosphorylation, and RhoA activity were also enhanced in spheroids with PDLIM2 suppressed compared to controls. Importantly, pharmacological inhibition of either FAK or Rho Kinase (ROCK) was sufficient to rescue the polarity defect and abrogate all the phenotypic changes in MCF10A cell spheroids caused by PDLIM2 suppression. We conclude that PDLIM2 mediates feedback regulation of the β1-integrin signalling pathway through FAK and RhoA that is essential for maintenance of polarized breast epithelial acinar structures, and for suppression of uncontrolled proliferation and cellular transformation. Citation Format: Ravi Kiran-Deevi, Orla T. Cox, Rosemary O'Connor. PDLIM2 is essential for feedback regulation of the B1 integrin-FAK-RhoA signalling pathway to maintain epithelial cell polarity and suppress transformation. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4458. doi:10.1158/1538-7445.AM2014-4458
Valuable insights from morbidity coding in primary care
Authors: Tom Fahey
Journal: BMJ (2004)

McAlister and colleagues present a challenging paper, which shows the value of high quality, routinely collected data in primary care.1Their research gives a representative picture of current clinical practice for patients with heart failure, highlighting the variations in diagnosis and follow up in relation to socioeconomic status. Their findings are consistent with evidence that shows socioeconomic status is an independent marker of admission to hospital in patients with heart failure.2They found that lower socioeconomic status was also an independent risk marker for development of heart failure and that patients from lower socioeconomic groups were less likely to consult their general practitioner …
Book: Desperately Seeking Solutions: Rationing Health Care
Authors: D. Price
Journal: BMJ (1999)

David J Hunter Addison Wesley Longman, $14.99, pp 176 ISBN 0 582 28923 8 Rating: ![Graphic][1]</img> Healthcare rationing, according to Professor Hunter's summary of the rationing debate, is inevitable and, since the case of “Child B,” which exploded the myth that the NHS would pay for any treatment, we all know that it is inevitable. However, rationing is difficult to justify, he says, because society is not yet ready for clear rules about when to deny medical … [1]: /embed/inline-graphic-1.gif