The Cadaveric Option
Authors: Alfonso Quintás-Cardama, Jesús Calviño, José-Luis Bello
Journal: Annals of Internal Medicine (2000)

Letters20 June 2000The Cadaveric OptionAlfonso Quintás-Cardama, MD, Jesús Calviño, MD, and José-Luis Bello, MDAlfonso Quintás-Cardama, MDHospital Clínico Universitario de Santiago; Santiago de Compostela, 15705 Spain (Quintás-Cardama)Hospital Clínico Universitario de Santiago; Santiago de Compostela, 15705 Spain (Calviño)Hospital Clínico Universitario de Santiago; Santiago de Compostela, 15705 Spain (Bello)Search for more papers by this author, Jesús Calviño, MDHospital Clínico Universitario de Santiago; Santiago de Compostela, 15705 Spain (Quintás-Cardama)Hospital Clínico Universitario de Santiago; Santiago de Compostela, 15705 Spain (Calviño)Hospital Clínico Universitario de Santiago; Santiago de Compostela, 15705 Spain (Bello)Search for more papers by this author, and José-Luis Bello, MDHospital Clínico Universitario de Santiago; Santiago de Compostela, 15705 Spain (Quintás-Cardama)Hospital Clínico Universitario de Santiago; Santiago de Compostela, 15705 Spain (Calviño)Hospital Clínico Universitario de Santiago; Santiago de Compostela, 15705 Spain (Bello)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-12-200006200-00027 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Bone marrow transplant nephropathy (1) is a radiation-induced syndrome similar to the hemolytic uremic syndrome that occurs 6 to 12 months after bone marrow transplantation (BMT). Because some patients require maintenance dialysis, renal transplantation might offer the best therapeutic option. Four cases of immunologic tolerance to renal allografts after BMT from the same donor have been reported (2). We report immunologic tolerance to cadaveric renal allografts after BMT.A 26-year-old woman underwent allogeneic BMT with bone marrow from her HLA-identical sister for acute myeloblastic leukemia (M2 FAB classification) in first complete remission. The conditioning regimen included cyclophosphamide ...References1. Cohen EP, Lawton CA, Moulder JE. Bone marrow transplant nephropathy: radiation nephritis revisited. Nephron. 1995;70:217-22. CrossrefMedlineGoogle Scholar2. Dey B, Sykes M, Spitzer TR. Outcomes of recipients of both bone marrow and solid organ transplants. Medicine Baltimore. 1998;77:355-69. CrossrefMedlineGoogle Scholar3. Billingham RE, Brent L, Medawar PB. “Actively acquired tolerance” of foreign cells. Nature. 1953;172:603-6. CrossrefMedlineGoogle Scholar4. Sayegh MH, Fine NA, Smith JL, Rennke HG, Milford EL, Tilney NL. Immunologic tolerance to renal allografts after bone marrow transplants from the same donors. Ann Intern Med. 1991;114:954-5. LinkGoogle Scholar Author, Article, and Disclosure InformationAuthors: Alfonso Quintás-Cardama, MD; Jesús Calviño, MD; José-Luis Bello, MDAffiliations: Hospital Clínico Universitario de Santiago; Santiago de Compostela, 15705 Spain (Quintás-Cardama)Hospital Clínico Universitario de Santiago; Santiago de Compostela, 15705 Spain (Calviño)Hospital Clínico Universitario de Santiago; Santiago de Compostela, 15705 Spain (Bello) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 20 June 2000Volume 132, Issue 12Page: 1007KeywordsBone marrowCyclophosphamideGraft vs host diseaseHemolytic-uremic syndromeImmunosuppressivesMedical dialysisMethotrexateProphylaxisRenal transplantationSteroids ePublished: 15 August 2000 Issue Published: 20 June 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...