tbuckley/cabot-search huggingface dataset:
Congenital Pyloric Stenosis in Three Successive Male Babies of the Same Parents
Authors: J. L. Adlington
Journal: BMJ (1949)

Malingering to obtain medications of abuse is well documented in the general medical setting. However, we have found no cases previously reported of such malingering in a veterinary setting. We report five cases submitted by veterinarians in which clients (pet owners) are strongly suspected or confirmed to have been engaging in malingering to obtain controlled medications for their personal use. Cases bear a striking resemblance to malingering in the general medical setting for drugs to abuse. We propose that veterinarians, like their medical counterparts, are potential targets of malingering by their clients for drugs of abuse. Because of their familiarity with this condition, psychiatrists may have a role in training veterinarians to recognize malingering on the part of their human clients. In addition, psychiatrists may benefit from familiarizing themselves with novel forms of malingering, such as are presented in this case series.
Functional characterization of left ventricular segmental responses during the initial 24 h and 1 wk after experimental canine myocardial infarction.
Authors: P Roan, F Scales, S Saffer, L M Buja, J T Willerson
Journal: Journal of Clinical Investigation (1979)

Characterization of the temporal evolution of resting segmental function and inotropic reserve after coronary occlusion may be important in evaluating attempts to salvage ischemic but non-necrotic myocardium. Accordingly, we chronically implanted up to six pairs of pulse-transit piezoelectric crystals in the left ventricular myocardium of dogs to measure segmental wall thickness. Segments were separated into groups according to the loss of net systolic thickening (NET) at 5 min postocclusion of the left anterior descending coronary artery in awake, unsedated dogs. Group 1 included segments with NET values of 67--100+ (percent control); group 2 between 67 and 0; and group 3 less than 0 (paradoxical motion). 5 min after coronary occlusion, group 1 NET was 92 +/- 5% (SEM) although significant decreases occurred in NET in group 2 (36 +/- 4%) and group 3 segments (-33 +/- 5%). Between 5 min and 24 h after coronary occlusion, no further significant changes occurred in NET in groups 1, 2, and 3 crystals. Some segments underwent further functional deterioration between 24 h and 1 wk after left anterior descending coronary artery occlusion, although no overall change occurred in segments with mild to moderate ischemic dysfunction. Segments with NET less than 0 at 24 h, on the other hand, exhibited a reduction in aneurysmal bulging between 24 h and 1 wk from -41 +/- 10 to -23 +/- 11% (n = 12, P = 0.02). Inotropic reserve was assessed with postextrasystolic potentiation (PESP) in 14 dogs, and with infusions of dopamine (11 dogs), and isoproterenol (13 dogs). PESP was the most potent intervention and produced a significant augmentation in NET in group 2 crystals at 1, 2, 4, 6,8, and 24 h after coronary occlusion but only at 1 and 2 h in NET in group 3 crystals. Thus, following experimental coronary occlusion, the evolution of ischemic segmental dysfunction is dynamic and variable. A significant degree of inotropic reserve, as assessed by PESP, dopamine, and isoproterenol, exists in segments with moderate ischemic dysfunction for 24 h but for only 2 h after coronary occlusion in those segments with the most severe ischemic dysfunction. In addition, at least some segmental sites with mild to moderate ischemic dysfunction at 24 h deteriorate further between 24 h and 1 wk after experimental coronary occlusion.
Rising incidence of SCLC in young women
Authors: M. L CARTMAN, M. F MUERS
Journal: Thorax (1999)

Venous aneurysm of the azygos arch is a very rare cause of mediastinal mass and is usually an incidental finding on chest radiography.Nowadays the diagnosis is made by non-invasive tests such as thoracic CT scanning and/or magnetic resonance imaging.The case is described of an asymptomatic woman in whom a mediastinal mass due to an azygos vein aneurysm was diagnosed by non-invasive procedures, the aetiology of which, in all probability, was idiopathic.
Laboratory testing for platelet antibodies
Authors: Nahla M. Heikal, Kristi J. Smock
Journal: American Journal of Hematology (2013)

Laboratory testing for immune-mediated thrombocytopenias involves identification and classification of antibodies present in patient sera or attached to patient platelets. This article summarizes the available types of platelet antibody testing and applications in disorders such as neonatal alloimmune thrombocytopenia, post-transfusion purpura, multiple platelet transfusion refractoriness, immune thrombocytopenia, and drug-induced thrombocytopenia.
Maurice Ravel's amusia
Authors: J. Warren
Journal: Journal of the Royal Society of Medicine (2003)

In their review, Paulo Andrade and Joydeep Bhattacharya (June 2003 JRSM1) revisit the subject of Maurice Ravel's last illness. The clinical notes of his neurologist, Alajouanine,2 indicate that Ravel developed slowly progressive apraxia and aphasia in late middle life. Although the true diagnosis will never be known, since a necropsy was not performed, the clinical picture would be compatible with one of the frontotemporal lobar dementias, possibly Pick's disease or corticobasal degeneration.3 What does seem clear is that Ravel's difficulties were chiefly motoric and expressive, leaving his musical intellect largely unaffected. It has been suggested previously4 that Bolero may represent musical perseveration, or at least a waning of Ravel's musical faculties. However, Ravel was always intensely interested in the technical aspects of his art, and there is evidence from his own correspondence that he composed Bolero as a study of crescendo, ‘orchestration without music’ (some would argue he succeeded only too well). Furthermore, the two piano concertos, completed after Bolero, are both masterpieces of the genre; the slow movement of the Concerto in G, in particular, is graced by a melody of Mozartian delicacy. Ravel's timbral mastery is undisputed, but he was also a melodist of rare invention, and there is little evidence that this gift deserted him even though he was tragically deprived of the means to realize his ideas. Perhaps the last words on the subject should be Ravel's own:


‘Et puis, j'avais encore tant de musique dans la tete.’

[And yet I still had so much music in my head]
Comparison of Serial Monitoring of Peak Expiratory Flow and FEV<sub>1</sub> in the Diagnosis of Occupational Asthma
Authors: CHRISTOPHE LEROYER, LUCA PERFETTI, CAROLE TRUDEAU, JOCELYNE L'ARCHEVÊQUE, MOIRA CHAN-YEUNG, JEAN-LUC MALO
Journal: American Journal of Respiratory and Critical Care Medicine (1998)

Peak expiratory flow (PEF) monitoring is often used to establish the relationship between occupational exposure and asthma. FEV1 has been found to be a better physiologic index than PEF in the measurement of airflow obstruction. The aim of this study was to compare the accuracy of serial monitoring of PEF and FEV1 in the diagnosis of occupational asthma. Twenty consecutive subjects referred for possible occupational asthma were asked to perform serial monitoring of PEF and FEV1 using a portable ventilometer. Two sets of graphs were plotted for both PEF and FEV1: graphs with the best of all values and graphs with the best of two reproducible values. Three observers interpreted both PEF and FEV1 recordings by the visual method in a blind, randomized manner as either compatible with occupational asthma or not. Eleven of the subjects had a positive inhalation challenge test (high-molecular-weight agents, n = 6; low-molecular-weight agents, n = 5). In the case of analysis of the graphs plotted with the best of all values, the sensitivity of the PEF recording interpreted by the three observers was 82, 73, and 73%, and of the FEV1 recording as 55, 55, and 45%; specificity of PEF recording was 89, 100, and 100%, and of FEV1 was 56, 89, and 100%. When an agreement between two of the three readers was required to define occupational asthma, sensitivity and specificity were 73 and 100% for PEF and 55 and 89% for FEV1. Lower sensitivities were found when the same analyses were performed with the graphs plotted with the best of two reproducible values. It was concluded that unsupervised FEV1 is not more accurate than unsupervised PEF monitoring in the diagnosis of occupational asthma. Plotting graphs using the best value gives better diagnostic accuracy than plotting them with the best of two reproducible values.
Difficult Times Ahead for Graduate Medical Education
Authors: John K. Iglehart
Journal: New England Journal of Medicine (1985)

The Reagan administration's call for a precipitous reduction in federal support for graduate medical education has provoked a new examination of the means used to finance the training of residents. Although it is too early to predict with precision the outcome of this dawning exercise, its consequences will probably include the demise of open-ended Medicare support for graduate medical education, a sharp reduction and perhaps eventual elimination of education subsidies funded through the Public Health Service, and closer scrutiny of the largely unfettered processes that constitute the world of graduate medical education.This examination of the practices and policies of . . .
Prevention of disease progression, left ventricular hypertrophy and congestive heart failure in hypertension treatment trials
Authors: Marvin Moser, Patricia R. Hebert
Journal: Journal of the American College of Cardiology (1996)

This work was done to determine the role of hypertension treatment in the prevention of disease progression, left ventricular hypertrophy and congestive heart failure.Lowering of blood pressure in hypertensive patients has been reported to reduce morbidity and mortality from strokes and myocardial infarction. Data on primary prevention of disease progression, left ventricular hypertrophy and congestive heart failure have not previously been carefully quantified.All the major long-term hypertension treatment trials over the past 20 years were reviewed.One thousand four hundred ninety-three of 13,342 subjects in the control groups compared with only 95 of 13,389 in the treated groups progressed from less severe to severe hypertension. The incidence of left ventricular hypertrophy in treated compared with control or placebo subjects was 140 of 6,150 and 216 of 6,098 subjects, respectively; congestive heart failure occurred in 240 of 6,923 subjects in the control group compared with only 112 of 6,914 treated subjects.The lowering of blood pressure over a 3- to 5-year period of time is effective in preventing severe disease, left ventricular hypertrophy and congestive heart failure in addition to strokes and myocardial infarction. In an era when expensive and often complicated methods are being used to prevent recurrence of congestive heart failure or myocardial infarction, it is important to highlight the role of antihypertensive therapy in primary prevention.
Comparative Effectiveness of Laparoscopic Adjustable Gastric Banding vs Laparoscopic Gastric Bypass
Authors: David Arterburn, J. David Powers, Sengwee Toh, Sarit Polsky, Melissa G. Butler, J. Dickman Portz, William T. Donahoo, Lisa Herrinton, Rebecca J. Williams, V. Vijayadeva, David Fisher, Elizabeth A. Bayliss
Journal: JAMA Surgery (2014)

IMPORTANCE Laparoscopic Roux-en-Y gastric bypass (RYGB) and laparoscopic adjustable gastric banding (AGB) are 2 of the most commonly performed bariatric procedures worldwide.However, few large, multisite studies have directly compared the benefits and harms of these procedures.OBJECTIVE To compare the effect of laparoscopic RYGB vs AGB on short-and long-term health outcomes.
Rate-dependent effects of diltiazem on human atrioventricular nodal properties.
Authors: M Talajic, R Lemery, D Roy, C Villemaire, R Cartier, B Coutu, S Nattel
Journal: Circulation (1992)

BACKGROUND Tachycardia enhances the channel-blocking effects of antiarrhythmic drugs. In contrast to the extensive data regarding the rate-dependent effects of sodium channel blockers in humans, little is known about the frequency-dependent effects of calcium channel blockers on human atrioventricular (AV) nodal properties. Accordingly, the purpose of this study was to evaluate the importance of heart rate in modulating the electrophysiological effects of diltiazem in humans. METHODS AND RESULTS Electrophysiological studies were performed in 25 patients. Sinus node, atrial, and AV nodal function were evaluated at multiple atrial rates under control conditions and after administration of one of three intravenous doses of diltiazem designed to produce low, intermediate, and high stable plasma concentrations (designated doses 1, 2, and 3, respectively). Results were analyzed in terms of the longest and shortest cycle lengths obtainable in each patient under control and drug conditions. Plasma concentrations of diltiazem were stable and averaged 43 +/- 4, 73 +/- 6, and 136 +/- 11 ng/ml for doses 1, 2, and 3, respectively. Sinus node recovery time, intra-atrial conduction time, atrial effective refractory period, and HV interval were unaffected by diltiazem infusion. Effects of diltiazem were limited to changes in AV nodal parameters. Stable, dose-dependent increases in Wenckebach cycle length were observed after all three doses of diltiazem (increases of 54 +/- 13, 84 +/- 18, and 174 +/- 33 msec for doses 1, 2, and 3, respectively). Small nonsignificant increases in AH interval and atrioventricular effective refractory period (AVERP) were observed after dose 1 of diltiazem. At long cycle lengths, diltiazem caused modest increases in AH interval (3 +/- 4 and 25 +/- 8 msec for doses 2 and 3, respectively) and AVERP (36 +/- 12 and 70 +/- 25 msec). Drug effects were far greater at short cycle lengths (45 +/- 17 msec, 58 +/- 12 msec for AH interval and 80 +/- 24 msec, 163 +/- 41 msec for AVERP; p less than 0.05 versus values at long cycle lengths). At rapid rates, effects of diltiazem on AVERP substantially exceeded those on AV conduction, a result that could account for the beneficial effects of diltiazem during paroxysmal AV reentrant tachycardia by decreasing the excitable gap. CONCLUSIONS Depressant effects of diltiazem on human AV nodal function are highly dependent on atrial rate; the rate-dependent actions on AV nodal refractoriness probably contribute to beneficial effects of diltiazem in patients with supraventricular arrhythmias.
Babies fed defective formula are still being treated for neurological damage
Authors: Judy Siegel-Itzkovich
Journal: BMJ (2004)

A year after the deaths from encephalopathy of two Israeli infants who were exclusively fed a soya formula made in Germany that lacked vitamin B1 (thiamin) ( BMJ 2003;327:1128) nine children are still being treated for serious neurological damage.

Although they regularly undergo blood tests and other procedures several of them feel no pain and never cry. A recent Israeli cable TV documentary on the most seriously disabled children showed them staring into space and barely able to move. While some babies being treated are improving, others seem to be irreversibly damaged.

A total of 35 …
Ischemic Colitis Masquerading as Colonic Tumor: An Unusual Endoscopic Presentation
Authors: H. H. Lee, F. P. Agha, C. Owyang
Journal: Endoscopy (1986)

A case of ischemic colitis masquerading as colonic submucosal tumor with no superficial mucosal lesion is reported. This unusual and less well known endoscopic presentation of colonic ischemia is emphasized and a rational approach to the management of ischemic colitis is discussed.
BAG3 Protein in Advanced-Stage Heart Failure
Authors: Margot De Marco, Raffaella D’Auria, Alessandra Rosati, Gennaro Vitulano, Alberto Gigantino, Rodolfo Citro, Federico Piscione, Jodi Zilinski, James L. Januzzi, Maria Caterina Turco
Journal: JACC Heart Failure (2014)
Hypersensitivity Pneumonitis Caused by a Contaminated Cool-Mist Vaporizer
Authors: GLENN R. HODGES
Journal: Annals of Internal Medicine (1974)

A patient with hypersensitivity pneumonitis caused by a contaminated cool-mist vaporizer, a previously unreported association, is presented. Although several fungal and bacterial organisms were isolated from the vaporizer, the specific antigen to which the patient was sensitive was not identified. Further evaluation suggested that an insoluble, particulate antigen not related to the microorganisms isolated from the vaporizer was the causal agent. This case reemphasizes the need to suspect hypersensitivity pneumonitis in all patients with "recurrent pneumonia."
TRICHOMYCOSIS AXILLARIS NIGRA: REPORT OF A CASE.*
Authors: MORRIS MOORE
Journal: British Journal of Dermatology (1938)

Journal Article TRICHOMYCOSIS AXILLARIS NIGRA: REPORT OF A CASE. Get access MORRIS MOORE, PH.D. MORRIS MOORE, PH.D. Mycologist to the Barnard Free Skin and Cancer Hospital; Barnes Hospital; and the Department of Dermatology of the School of Medicine, Washington University; St. Louis, Missouri Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 50, Issue 12, 1 December 1938, Pages 659–661, https://doi.org/10.1111/j.1365-2133.1938.tb10448.x Published: 01 December 1938
A Case of Puerperal Infection Treated by Operation (Pryor's Method)
Authors: N. S. Fraser
Journal: BMJ (1901)

traction on the foot.In cases of incomplete placenta praevia under this heading, the treatment, with the exception of rupture of the membranes, instead of perforation of the placenta, is identical.Now, when one considers that owing to the attachment of the placenta the cervix and lower uterine segment is extremely soft and vascular, and as Dr. Siilyly says, " tears like
Abstract 5180: Profiling signaling pathways in chronic lymphocytic leukemia using reverse phase protein array
Authors: Satish Kumar R. Noonepalle, Austin Shull, Farrukh T. Awan, Leah Pei, Zhiyong Ding, Huidong Shi
Journal: Cancer Research (2014)

Abstract Chronic lymphocytic leukemia (CLL), the most common adult leukemia remains incurable despite advancements in treatment regimens over the past decades. B-cell receptor (BCR) mediated signaling is well recognized for its central role in the pathogenesis of CLL. Small molecular inhibitors targeting BCR signaling pathway and its downstream PI3K/AKT pathway are currently investigated in clinical trials because of their ability to induce apoptosis or block protein interactions in CLL cells. However, variability in pathological conditions and genetic aberrations render these small molecule inhibitors not equally effective in all CLL patients and highlights the need for individualized treatment options. In this pilot study, we analyzed differential protein expression of 18 CLL patient and 6 normal B-cell samples using reverse phase protein array (RPPA). RPPA enables us to study the proteome as well as phospho-proteome of CLL samples. When probed with 167 monoclonal antibodies RPPA revealed distinct protein expression patterns between CLL and normal B-cells. RPPA data was analyzed by unsupervised hierarchical clustering and CLL patient samples were clearly separated from normal B-cell samples. Proteins of BCR and downstream PI3K/AKT pathway such as SYK, LCK, PDK1, AKT, RICTOR, mTOR, TSC1, TSC2 and p70S6K were all upregulated in CLL samples. Harvesting the full potential of RPPA to study phosphorylation changes, we observed an increase in PI3K pathway activating signals such as PDK1-pS241, p70S6K-pT389, 4EBP1-pS65 and 4EBP1-pT70 suggesting a cell proliferative mechanism. There was also decrease in inhibitory signals such as RICTOR-pT1135. Pro-apoptotic factors BID, BAX, Caspase 7-cleaved and ANXA1 were poorly expressed in CLL samples compared to normal B-cells suggesting a defect in apoptosis mechanism is predominant in CLL samples. As previously reported, we have seen overexpression of anti-apoptotic factor BCL2. BIM isoforms, BIM-EL and BIM-L were overexpressed in CLL compared to normal samples; however the ratio of BIM-EL to BIM-L was higher in normal B cells compared to CLL cells. For the first time, we generated a comprehensive BCR protein and phospho-protein expression profiles in primary CLL samples. Our results reveal novel anti-apoptosis and cell proliferative mechanisms in CLL and potentially identified new therapeutic targets in CLL. Citation Format: Satish Kumar R. Noonepalle, Austin Shull, Farrukh T. Awan, Leah Pei, Zhiyong Ding, Huidong Shi. Profiling signaling pathways in chronic lymphocytic leukemia using reverse phase protein array. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 5180. doi:10.1158/1538-7445.AM2014-5180
Richard John West
Authors: D. Hall
Journal: BMJ (2010)

Richard John West was awarded a scholarship to the Middlesex Hospital and trained as a paediatrician at Queen Mary’s Hospital for Children, Carshalton, and at Great Ormond Street Hospital. He worked closely with the late Professor June Lloyd on lipid disorders, and his MD thesis was on familial hypercholesterolaemia and its treatment.

He was appointed consultant paediatrician …
Thrombolysis and Angioplasty in Myocardial Infarction (TAMI-1) trial: Influence of infarct location on arterial patency, left ventricular function and mortality
Authors: Eric R Bates, Robert M Califf, Richard S Stack, Lynne Aronson, Barry S George, Richard J Candela, Dean J Kereiakes, Charles W Abbottsmith, Linda Anderson, Bertram Pitt, William W O'Neill, Eric J Topol
Journal: Journal of the American College of Cardiology (1989)
The Role of Noninvasive Cardiac Testing after an Uncomplicated Myocardial Infarction
Authors: Peter F. Cohn
Journal: New England Journal of Medicine (1983)

Just as treatment for the acute phase of a myocardial infarction has undergone radical changes in the past decade, so has the perception of what constitutes proper post-infarction evaluation. Although physicians can still learn much from the clinical picture combined with the standard chest film and resting electrocardiogram, an imposing array of noninvasive cardiac tests is now available for the early evaluation of the post-infarction patient. The most important of these are exercise (stress) electrocardiograms, 24-hour ambulatory electrocardiograms, and several types of radionuclide procedures. The purpose of this brief review is to help the practitioner to understand the indications, safety, . . .
Hospital Care — The Social Atom
Authors: John Lister
Journal: New England Journal of Medicine (1955)

THE demand on the hospital service seems to grow each year. Nearly all hospitals can show a steady rise in their outpatient attendance figures, and, in spite of an increase of about 25,000 hospital beds since 1949, there is in many areas a long waiting time for nonurgent admissions.The postwar development of new industrial and housing areas has also caused inadequate hospital facilities in many districts. For these reasons, the announcement by the Ministry of Health of a building program for new hospitals has been welcomed as being long overdue. It has also served to emphasize once more the . . .