tbuckley/cabot-search huggingface dataset:
Monographs by Department of Drugs
Authors: Mary Ellen Kosman
Journal: JAMA (1980)

<h3>To the Editor.—</h3> Because of an unfortunate placement of acknowledgments in my recent monograph on ticrynafen (242:2876, 1979), I have received several critical letters from physicians who assumed that publications from the American Medical Association Department of Drugs are written in conjunction with consultants from the drug industry. This is not the case. Our monographs are prepared by members of the staff of the Department of Drugs and are based on a review of published articles plus unpublished data furnished by the drug company. The original draft is then sent to a panel of independent consultants who are experts in their field and who have had experience with the drug. The manuscript is then revised on the basis of the comments and suggestions of these consultants before it is submitted toThe Journalfor publication. The monograph on ticrynafen was reviewed by experts in the areas of hypertension, congestive heart
VALIDITY OF AUTOMATED GLOBAL LONGITUDINAL STRAIN MEASUREMENTS WITH LOW-DOSE DOBUTAMINE STRESS ECHOCARDIOGRAPHY FOR THE ASSESSMENT OF MYOCARDIAL VIABILITY AFTER ACUTE MYOCARDIAL INFARCTION: COMPARISON WITH DELAYED ENHANCEMENT AND MICROVASCULAR OBSTRUCTION BY CARDIAC MAGNETIC RESONANCE IMAGING
Authors: Eiichi Hyodo, Koichi Tamita, Takahiro Tokuda, Mika Maeda, Toshiharu Iwamura, Atsushi Yamamuro, Kenei Shimada, Minoru Yoshiyama, Junichi Yoshikawa
Journal: Journal of the American College of Cardiology (2014)
IgE binding of the recombinant allergen soybean profilin (rGly m 3) is mediated by conformational epitopes☆☆☆
Authors: Hans-Peter Rihs, Zhiping Chen, Franziska Ruëff, Arnd Petersen, Peter Rozynek, Heike Heimann, Xaver Baur
Journal: Journal of Allergy and Clinical Immunology (1999)
Massive Extraglandular Aromatization of Plasma Androstenedione Resulting in Feminization of a Prepubertal Boy
Authors: David L. Hemsell, Clare D. Edman, James F. Marks, Pentti K. Siiteri, Paul C. MacDonald
Journal: Journal of Clinical Investigation (1977)

This report describes the mechanism of origin and the quantity of estrogen produced in a prepubertal boy who developed severe feminization at 8 yr of age as the result of a heretofore undescribed metabolic abnormality. The clinical findings were gynecomastia and accelerated linear growth and bone maturation. At the time feminization developed, there were no signs of growth or development of the otherwise normal prepubertal male external genitalia or any increase of muscle mass that normally accompanies male puberty.
Josiah Macy, Jr. Foundation, Transactions of the Sixth Conference on Cold Injury. July 6, 7, 8, 9, 10, 1958
Authors: F. T. Jung
Journal: JAMA (1961)

The transactions of the first of these important conferences on cold injury were reviewed inThe Journal, July 12, 1952. This volume, reporting on the sixth conference, is as interesting as the first. The two opening chapters deal respectively with induced and natural hibernation in mammals. The next three deal with experiences and experiments in Antarctica, and are full of practical details. Five chapters deal with laboratory experimentation on chill, shivering, and metabolism in cold environments. A final chapter deals with field studies on adaptation and collates the important observations made by Scholander and his colleagues on Norwegians, Lapps, and Eskimos with those made on Australian aborigines. Each chapter begins with a planned presentation by one speaker. This is followed by a group interchange. Each chapter ends with a short bibliography, and the book is provided with a good index.  Worthy of comment is the introduction of the new unit,
Identification of tryptase‐ and chymase‐related gene clusters in human mast cells using microarrays
Authors: C. Dahl, H. Saito, M. Kruhøffer, P. O. Schiøtz
Journal: Allergy (2005)

Tryptase and chymase are the two major granular proteases present in human mast cell (MC)s. We used oligonucleotide microarray to measure the levels of approximately 22 000 transcripts in cord blood‐derived MCs at 4 weeks, 8 weeks, 12 weeks and 18 weeks in culture. Tryptase ( TPSB2 ) was expressed at the highest level among all transcripts and its expression level reached a plateau at 8 weeks. On the other hand, the expression level of chymase ( CMAI ) doubled every 4–6 weeks. A similar tendency was found at the protein levels with FACS analysis. After filtering the transcripts with MC‐specificity, hierarchical clustering analysis identified 494 and 81 transcripts in the same clusters with tryptase and chymase, respectively. MC‐specific genes, KIT and HDC were found in the tryptase cluster. In the chymase cluster, a critical suppressor for cell senescence, BMI1 and the several related genes were found, suggesting that chymase expression may be closely related to cell senescence/quiescence events.
IMPORTANCE LUNG IMPEDANCE-GUIDED TREATMENT OF THE PATIENTS WITH ACUTE MYOCARDIAL INFARCTION FOR PREVENTING ACUTE HEART FAILURE AND REDUCING LONG-TERM MORTALITY
Authors: Michael Shochat, Avraham Shotan, Mark Kazatsker, Vladimir Gurovich, Elena Naiman, Lubov Vasilenko, Aya Asif, Ilia Shochat, Yaniv Levy, Dabid Blondheim, Simcha Meisel
Journal: Journal of the American College of Cardiology (2011)
Coagulation Defects—Bleeding Tendencies.
Authors: J. H. Lewis
Journal: Annals of Internal Medicine (1961)

s1 May 1961Coagulation Defects—Bleeding Tendencies.J. H. Lewis, M.D.J. H. Lewis, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-54-5-1052_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Excerpt1. Normal hemostatic mechanisms.2. Classification of hemorrhagic diseases, both primary and secondary.3. Differential diagnostic methods.4. Research approaches to the problems of blood coagulation and hemostasis.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Pittsburg, Pa. (ML) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1961Volume 54, Issue 5Page: 1052-1052KeywordsBlood coagulationHemostasisHemostatics ePublished: 1 December 2008 Issue Published: 1 May 1961 PDF downloadLoading ...
Lack of effect of growth hormone therapy on the count and density of melanocytic naevi in children
Authors: A. ZVULUNOV, D.T. WYATT, P.W. LAUD, N.B. ESTERLY
Journal: British Journal of Dermatology (1997)

An observation of accelerated growth of acquired melanocytic naevi (AMN) during treatment with human growth hormone (GH) raised concerns about the potential risk of melanoma in treated patients. An increased number of AMN, rather than growth rate, is associated with a higher risk for melanoma. It is unknown whether treatment with GH causes an increase in numbers of AMN. We evaluated the effect of GH treatment on the number of AMN in a cross-sectional study of 90 children with GH deficiency. AMN counts and densities in these children were compared with those found in a control group of 100 children. Factors potentially related to increased numbers of AMN, such as age, sex, skin colour, number of episodes of sunburn and duration of GH therapy were determined. Among the various factors, only the age and colour of unexposed skin area were predictive for the total number and density of AMN. No correlation was found between the AMN counts or density and the duration of GH therapy. There was no difference in AMN counts or density between the GH-deficient patient group and the control groups. We conclude that GH therapy in children is not associated with increased AMN count and density and is unlikely to potentiate the risk for melanoma in these children.
Maintenance treatment with cyclosporin in atopic eczema
Authors: C.S. MUNRO, N.J. LEVELL, S. SHUSTER, P.S. FRIEDMANN
Journal: British Journal of Dermatology (1994)

Summary We have studied two reducing-dose regimens intended to minimize toxicity of cyclosporin A (CyA) while maintaining its capacity to control atopic eczema following induction of remission. Twenty-four patients with severe chronic atopic eczema were first treated in a double-blind randomized placebo-controlled cross-over study of CyA (5 mg/kg/day). All 19 who completed the study showed the expected highly significant improvements, compared with placebo, in area involved, erythema, excoriation, lichenification, itch and requirement for topical steroid. In 17 of the 19 patients, control was re-established with CyA 5 mg/kg/day, and they were then re-randomized to stepwise reduction at 2-week intervals in either (i) the dose of CyA given daily, or (ii) the frequency with which the 5 mg/kg dose was given. Fifteen patients (seven continuous reducing dose, eight intermittent fixed dose) completed the planned reduction to either 1 mg/kg/day or 5 mg/kg every fifth day. In both groups the response was sustained despite dose reduction, although control was less good at a continuous dose of 1 mg/kg. Intermittent treatment was as good as or better than continuous reducing dosage in this study, and in both groups there was further deterioration after the drug was stopped. The findings suggest that the dose of CyA required to control atopic eczema is less than that required to achieve remission, and that the therapeutic index can be further improved by alternative dosing strategies. This offers a new approach to maintenance treatment of eczema and other chronic refractory dermatoses.
Monitoring and evaluating Working for Patients.
Authors: K. Judge
Journal: BMJ (1989)

continue then several problems need to be resolved.Firstly, it may be prudent to adhere to the recommendations made in the 1979-81 confidential inquiry into maternal morbidity"2 and establish one or more teams in the receiving hospitals with expertise in managing such conditions as worsening pre-eclamptic toxaemia.Advice could then be given before transfer.Secondly, the receiving hospitals must continue to encourage both medical and midwifery staff to maintain their abilities to deal with severely ill mothers who are highly dependent, as routinely accepting compromised patients will inevitably lead to an increase in the incidence of maternal morbidity.Whichever option is chosen, however, it seems that a much fuller assessment of the risks to the mother must be undertaken before transfer.In many cases these may outweigh the risks to the fetus.
Abstract 3899: Anti-cancer drugs increases microsatellite instability in human colorectal cancer cells
Authors: Christina L. Chang, Chien-Yuan Chiu, Jhih-Ying Chi, Chang-Lin Wu Chang-Lin Wu, I-Chen Li, Siao-Ru Jian
Journal: Cancer Research (2011)

Abstract Manifested as microsatellite instability (MSI), DNA mismatch repair (MMR) deficiency is known to contribute to colorectal cancer pathogenesis and drug resistance. Growing evidence indicates that MMR deficiency is also widespread among secondary cancers in patients who have received chemotherapy. It is unclear what chemotherapeutic agents cause MMR deficiency. In this study, we aim at identifying the MSI-inducing anti-cancer drugs. To facilitate the identification, we developed an in-vivo dual fluorescent reporter system in a human colorectal cancer cell model using RFP that contains a microsatellite as the MSI reporter and GFP as the cell label. Based on flow cytometric analysis, we found that test anti-cancer drugs increased the MSI frequency in a dose-dependent manner. This was confirmed by fluorescent microscopy. With the NCI recommended markers, we detected a low frequency of MSI in cells after treated with a couple, but not all, of test anti-cancer drugs. Our cell-based MSI reporter assay will facilitate large scale screens of MSI-inducing and MSI-reducing drugs/compounds, which might provide treatment strategies for controlling therapy-related secondary cancers. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3899. doi:10.1158/1538-7445.AM2011-3899
A peculiar case of autoimmune pancreatitis and sclerosing cholangitis
Authors: H.-M. Curth, U. Drebber, D. Stippel, C. Bangard, U. Töx, H.-M. Steffen
Journal: Endoscopy (2012)

A 65-year-old man presented with recurrent abdominal pain and slight weight loss. Computed tomography (CT) and endoscopic ultrasound (EUS) revealed a hypodense, partially cystic mass located in the pancreatic body and tail that raised the suspicion of pancreatic cancer ([Fig. 1]). No distant metastases were detected and the patient underwent surgical resection of the mass and splenectomy, which was complicated by a bleeding splenic artery aneurysm. Surprisingly, only massive inflammation of the pancreas was found on histological examination of the resected specimen.
Antiphospholipid Antibodies in Pregnancy
Authors: Anne Lynch
Journal: Annals of Internal Medicine (1994)

Letters1 October 1994Antiphospholipid Antibodies in PregnancyAnne Lynch and Woodruff EmlenAnne LynchUniversity of Colorado Health Sciences Center, Denver, CO 80262.Search for more papers by this author and Woodruff EmlenUniversity of Colorado Health Sciences Center, Denver, CO 80262.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-121-7-199410010-00026 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We welcome the comments of Scopelitis and colleagues and apologize for misquoting their abstract [1]. Although both studies [2, 3] reach similar conclusions regarding the association of elevated IgG anticardiolipin antibodies and fetal loss, they differ in the choice of study population, timing of anticardiolipin antibody determination, and the quantitative measure of these antibodies associated with fetal loss. Perez and colleagues [2] studied the prevalence of the antibodies in 1200 unselected, pregnant, African-American women. An elevated antibody level was found in 1.25%. In contrast, we prospectively studied a low-risk, predominantly white population [3]. We found an elevated antibody ...References1. Brown HL, Perez MC, Wilson W, Scopelitis E. Anticardiolipin antibodies in an unselected obstetric population: relationship to fetal outcome (Abstract). Society of Perinatal Obstetricians. Tenth Annual Meeting, January 23-27, 1990. Google Scholar2. Perez MC, Wilson WA, Brown HL, Scopelitis E. Anticardiolipin antibodies in unselected pregnant women: relationship to fetal outcome. J Perinatol. 1991; 11:33-6. Google Scholar3. Lynch A, Marlar R, Murphy J, Davila G, Santos M, Rutledge J, et al. Antiphospholipid antibodies in predicting adverse pregnancy outcome. A prospective study. Ann Intern Med. 1994; 120:470-5. Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Colorado Health Sciences Center, Denver, CO 80262. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAnti-β2-glycoprotein-I and anti-phosphatidylserine antibodies in women with spontaneous pregnancy lossAnti-cardiolipin antibody and anti-cardiolipin beta-2-glycoprotein I antibody in patients with recurrent fetal miscarriage 1 October 1994Volume 121, Issue 7Page: 547-548KeywordsAntibodiesAntibody productionFetusesPregnancy ePublished: 15 August 2000 Issue Published: 1 October 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Circadian variation in the frequency of sudden cardiac death.
Authors: J E Muller, P L Ludmer, S N Willich, G H Tofler, G Aylmer, I Klangos, P H Stone
Journal: Circulation (1987)

To determine whether sudden cardiac death exhibits a circadian rhythm similar to that recently demonstrated for nonfatal myocardial infarction, we analyzed the time of day of sudden cardiac death as indicated by death certificates of 2203 individuals dying out of the hospital in Massachusetts in 1983. The data reveal a prominent circadian variation of sudden cardiac death, with a low incidence during the night and an increased incidence from 7 to 11 A.M. The pattern is remarkably similar to that reported for nonfatal myocardial infarction and episodes of myocardial ischemia. The finding that the frequency of sudden cardiac death is increased in the morning is compatible with hypotheses that sudden cardiac death results from ischemia or from a primary arrhythmic event. Further study of the physiologic changes occurring in the morning may provide new information supporting or refuting these hypotheses, thereby leading to increased understanding and possible prevention of sudden cardiac death.
The effect and therapeutic mechanism of a Chinese herbal formula Shu-Bi-Lin (SBL) in the treatment of allergic rhinitis—Animal study and In Vitro study
Authors: Y. Zhao, P.C. Leung, K.S. Woo, G.G. Chen, Y.O. Wong, L.H. Wang, C.A. van Hasselt
Journal: Journal of Allergy and Clinical Immunology (2005)
Questions for general practice
Authors: A. Howitt
Journal: BMJ (2003)

Tudor Hart describes the real stuff of primary medical care as the steady unglamorous slog of anticipatory care, where the exciting things have been events that have not happened.1 When acute events do occur, as in this case, the electronic responses from Bossano and Trivanovic rightly highlight the difficulties in diagnosing chest pain in the community without access to sophisticated investigations.2

Good consultation skills are always important. Peter Hartl's description of his pain before admission …
Longevity of women G.P.s.
Authors: J G Denholm
Journal: BMJ (1973)

digitalization, during which they used an arbitrary fixed dosage schedule.They also give no information on the severity of the cardiac failure in their series of 43 children and the only comment on the clinical re- sponse is that "no toxic symptoms were noted on this regimen, and heart rate and failure were well controlled."Digoxin was administered to all their patients by mouth as an elixir.Are they suggesting that intramuscular digoxin is un- necessary in cardiac failure or is the implication that in all their patients the failure was mild enough to permit oral therapy?If the authors could provide the supplementary data on the clinical aspects of their cases, this would help considerably in the evaluation of their suggested dosage regimen.
Surgeon-Modified Fenestrated Endograft to Treat Ruptured Juxtarenal Aneurysm
Authors: George T. Pisimisis, Panagiotis Kougias, Neal R. Barshes, Carlos F. Bechara
Journal: JAMA Surgery (2014)

No endovascular devices are commercially available in the United States to treat high-surgical risk patients with aneurysms extending to visceral arteries. Treatment options are even further limited for symptomatic patients in need of urgent treatment.To describe a successful urgent endovascular repair of a juxtarenal abdominal aortic aneurysm with contained rupture.A hybrid suite using a surgeon-modified fenestrated endovascular graft and advanced 3-dimensional imaging workstation. The patient was an 82-year-old veteran taking clopidogrel and aspirin for coronary stents with significant cardiopulmonary comorbidities including multiple prior abdominal surgeries and a single functional left kidney.Surgeon-modified fenestrated endovascular aortic aneurysm repair.Clinical, laboratory, and radiographic improvement.The patient was discharged 5 days after an uneventful postoperative course. On short-term follow-up, the patient had an early return to his baseline functional status. The excluded aneurysm sac shrank with patent visceral branches and there was an absence of endoleak on 3-month and 6-month surveillance computed tomography angiography.Surgeon-modified fenestrated stent grafts may be a viable option for selected high-surgical risk patients with symptomatic complex abdominal aortic aneurysms.
Micropuncture study of hypertonic mannitol diuresis in the proximal and distal tubule of the dog kidney
Authors: John F. Seely, John H. Dirks
Journal: Journal of Clinical Investigation (1969)

Fractional reabsorption of water, sodium, and potassium at proximal and distal tubular sites within the nephron was studied by recollection-micropuncture experiments on dogs undergoing hypertonic mannitol diuresis. After an initial control hydropenic phase, 16% mannitol in modified Ringer's solution was administered intravenously, resulting in marked increases in fractional excretion of water (28.7%), sodium (12.6%), and potassium (63.9%). Inulin clearance decreased significantly from 35.1 to 25.2 ml/min. Analysis of paired micropuncture data revealed a significant decrease in tubule fluid to plasma (TF:P) inulin ratios in both the proximal tubule (1.63-1.45) and distal tubule (5.38-1.94). There was also a significant decrease in proximal TF:P sodium ratios (0.99-0.93) and potassium ratios (1.05-0.98). Distal TF:P sodium ratios, in contrast, rose significantly (0.38-0.59), while TF:P potassium ratios tended towards unity whether initially greater or less than one. Fractional reabsorption of sodium and water decreased by 5% and 10% respectively in the proximal tubule, but to a lesser extent than the resulting increases in fractional urinary excretion. The nonreabsorbed fraction, however, had increased sharply at the point of distal puncture for water (32%), sodium (26%), and potassium (26%), indicating a large inhibitory effect within the loop of Henle in addition to the smaller proximal effects.
Effect of common agonists on cytoplasmic ionized calcium concentration in platelets. Measurement with 2-methyl-6-methoxy 8-nitroquinoline (quin2) and aequorin.
Authors: J A Ware, P C Johnson, M Smith, E W Salzman
Journal: Journal of Clinical Investigation (1986)

Because of controversy regarding the relationship of cytoplasmic ionized calcium concentration ([Cai2+]) to platelet activation, we studied the correlation of platelet aggregation and ATP secretion with [Cai2+] as determined by 2-methyl-6-methoxy 8-nitroquinoline (quin2) and aequorin in response to ADP, epinephrine, collagen, the Ca2+ ionophore A23187, and thrombin. Both indicators showed a concentration-dependent increase in [Cai2+] in response to all agonists except epinephrine when gel-filtered platelets were suspended in media containing 1 mM Ca2+. With epinephrine, a rise in [Cai2+] was indicated by aequorin, but not by quin2; [Cai2+] signals, aggregation, and secretion were suppressed by EGTA. ADP [0.5 microM] produced a rise in [Cai2+] that was registered by both aequorin and quin2 in platelets in Ca2+-containing media; addition of EGTA to the medium raised the threshold concentration of ADP to 5.0 microM for both indicators. Collagen produced progressive concentration-related increases in [Cai2+] and aggregation in aspirin-treated aequorin-loaded platelets. Quin2 failed to indicate a rise in [Cai2+]at lower collagen concentrations with EGTA or aspirin. [Cai2+] response to A23187 and thrombin was reduced by addition of EGTA to platelets loaded with either aequorin or quin2. With all five agonists in all conditions tested, aequorin [Cai2+] signals occurred at the same agonist concentration as that or lower than that which produced platelet shape change, aggregation, or secretion. Platelet activation was better correlated with changes in [Cai2+] indicated by aequorin than with the response of quin2, possibly because aequorin is more sensitive to local zones of [Cai2+] elevation.