tbuckley/cabot-search huggingface dataset:
Hopes for a health legacy from the Olympic games should focus on community not sport, says expert
Authors: C. White
Journal: BMJ (2011)

Inappropriate government policy and a lack of dedicated resources are likely to scupper hopes of a broad and sustainable effect on people’s health behaviour stemming from the London Olympic and Paralympic games, delegates at a conference on the effects of the 2012 games were told on 29 June.

The Centre for Sport, Physical Education and Activity Research (SPEAR) at Canterbury Christ Church University was asked by the Department of Health for England to produce a comprehensive review on the international evidence on the role and potential of the games. Published in January 2009, this showed that the Olympics could boost the nation’s physical activity levels, “given the right strategic approach and investment,” explained Mike Weed, who heads the centre. 

But government policy was not based on evidence and placed too much emphasis …
Deleterious Effect of Prednisolone in HBsAg-positive Chronic Active Hepatitis
Authors: Kui Chun Lam, Ching Lung Lai, R. P. Ng, Christian Trepo, P. C. Wu
Journal: New England Journal of Medicine (1981)

To study the efficacy of corticosteroids in chronic active hepatitis (CAH) positive for hepatitis B surface antigen (HBsAg), we pair-randomized 51 patients to receive either 15 to 20 mg of prednisolone per day or a placebo. After initial remission, the maintenance dosage of prednisolone was 10 mg per day, and the patients were prospectively followed for up to 3 1/2 years. Prednisolone decreased serum bilirubin (P<0.05) and globulin (P<0.01) at three months; it delayed other biochemical remission occurring after the second month of medication (P<0.001); it hastened biochemical relapse (P<0.0001); and it increased the frequency of complications (P<0.0001) and the death rate (P<0.01). We conclude that prednisolone has an overall harmful effect in patients with HBsAg-positive CAH. (N Engl J Med. 1981; 304:380–6.)
Benzodiazepines and traffic accidents.
Authors: I Hindmarch
Journal: BMJ (1979)

diseases.Also, in the light of past investigations, I agree that all patients on psychotropic drugs should be warned that their driving might be adversely affected by their drugs and that this effect can be aggravated by alcohol.If all medical practitioners give this warning and all patients heed it, we are going to find it even more difficult to carry out the randomised control trial that is so badly needed.
Alcohol and Renal Function
Authors: SERGIO DE MARCHI
Journal: Annals of Internal Medicine (1984)

Letters and Corrections1 July 1984Alcohol and Renal FunctionSERGIO DE MARCHI, M.D., EMANUELA CECCHIN, M.D., FRANCO GRIMALDI, M.D., ANTONIO BASILE, M.D.SERGIO DE MARCHI, M.D.Search for more papers by this author, EMANUELA CECCHIN, M.D.Search for more papers by this author, FRANCO GRIMALDI, M.D.Search for more papers by this author, ANTONIO BASILE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-101-1-145_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We read with interest the UCLA conference on alcoholism (1). From our experience in a wine-producing district of northeast Italy, we report some nephrologic effects of alcohol abuse in chronic alcoholics. Derangements of plasma composition, including hypokalemia, hypomagnesemia, and hypophosphatemia, have been described among the metabolic effects of alcoholism (2-4). The effects of drinking on renal function are, however, still controversial and largely unknown.The discovery of an unexplained alkaline urine pH in a significant percentage of heavy drinkers prompted us to investigate some aspects of their tubular function. We studied 75 patients (age 22 to 73...References1. WEST L, MAXWELL D, NOBLE E, and SOLOMON D. Alcoholism. Ann Intern Med. 1984;100:405-16. LinkGoogle Scholar2. KNOCHEL J. Hypophosphatemia in the alcoholic. Arch Intern Med. 1980;140:613-5. CrossrefMedlineGoogle Scholar3. KNOCHEL J. Derangements of phosphate, magnesium and calcium homeostasis in chronic alcoholism. In: EPSTEIN M, ed. The Kidney in Liver Disease. New York: Elsevier Science Publishing Co.; 1983:203-27. Google Scholar4. ESTEP H, SHAW W, WATLINGTON C, HOBE R, HOLLAND W, and TUCKER S. Hypocalcemia due to hypomagnesemia and reversible parathyroid hormone unresponsiveness. J Clin Endocrinol Metab. 1969;29:842-8. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: SERGIO DE MARCHI, M.D.; EMANUELA CECCHIN, M.D.; FRANCO GRIMALDI, M.D.; ANTONIO BASILE, M.D.Affiliations: Stabilimento Ospedaliero di Codroipo (USL N°7) 33033 Codroipo (Udine) Italy PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySomnolence, hypotension, and metabolic acidosis following high-dose teniposide treatment in children with leukemiaThe importance of the intraindividual variability of renal function parameters used in occupational health 1 July 1984Volume 101, Issue 1Page: 145-145KeywordsAlcoholicsAlcoholismAlcoholsBlood plasmaHypomagnesemiaUrine ePublished: 1 December 2008 Issue Published: 1 July 1984 PDF downloadLoading ...
Spondyloarthropathy Associated with Hidradenitis Suppurativa and Acne Conglobata
Authors: ITZHAK A. ROSNER
Journal: Annals of Internal Medicine (1982)

We evaluated 10 patients with hidradenitis suppurative or acne conglobata who developed arthritis. In contrast to patients with acne fulminans and arthritis, all our subjects were adults over 22 years of age; nine were black; and four were women. Nine patients had episodic inflammatory oligoarthritis affecting mainly larger joints of the upper and lower extremities. Eight patients had roentgenographic evidence of peripheral arthritis, four with erosions. Nine had clinical axial arthropathy, but roentgenograms showed abnormalities of the axial skeleton in all 10 patients. Pyoderma gangrenosum, erythema nodosum, conjunctivitis, urethritis, and oral and penile ulcers occurred in some patients. Rheumatoid factor was negative in all patients; the erythrocyte sedimentation rate was elevated in nine; five had chronic anemia; four had circulating immune complexes; and complement components were elevated in four. There was no increased incidence of HLA-B27 or other HLA-B7 cross-reacting antigens. A temporal relation of skin and joint disease activity was suggested. We report a spondyloarthropathy associated with hidradenitis suppurativa and acne conglobata. Clinical and laboratory manifestations suggest the arthropathy may be reactive to chronic cutaneous infection.
423 PAIRED BIOPSY COMPARISON OF TWO LIVER FIBROSIS MARKER PANELS (HCV FIBROTEST, HEPASCORE) IN FOLLOWING HISTOLOGICAL RESPONSE TO ANTIVIRAL THERAPY FOR CHRONIC HEPATITIS C (CHC)
Authors: A. Thompson, L. Elliott, H. Tillmann, J. McHutchison, K. Patel
Journal: Journal of Hepatology (2009)
Loss-of-function mutations in MGME1 impair mtDNA replication and cause multisystemic mitochondrial disease
Authors: Cornelia Kornblum, Thomas J Nicholls, Tobias B Haack, Susanne Schöler, Viktoriya Peeva, Katharina Danhauser, Kerstin Hallmann, Gábor Zsurka, Joanna Rorbach, Arcangela Iuso, Thomas Wieland, Monica Sciacco, Dario Ronchi, Giacomo P Comi, Maurizio Moggio, Catarina M Quinzii, Salvatore DiMauro, Sarah E Calvo, Vamsi K Mootha, Thomas Klopstock, Tim M Strom, Thomas Meitinger, Michal Minczuk, Wolfram S Kunz, Holger Prokisch
Journal: Nature Genetics (2013)
Accumulation of molecules involved in α1-adrenergic signal within caveolae: caveolin expression and the development of cardiac hypertrophy
Authors: T Fujita
Journal: Cardiovascular Research (2001)

Caveolin, a major protein component of caveolae, is now considered to be an inhibitor of cellular growth and proliferation. In this study, we examined the localization of the molecules involved in alpha1-adrenergic receptor signal relative to that of caveolin in the heart and the changes in caveolin expression during the development of hypertrophy in SHR.We purified the caveolar protein fractions from rat cardiac tissues, H9C2 cells, and rat vascular smooth muscle cells. Using radioligand receptor binding assay and immunoblot analysis, we examined the distribution and the amount of alpha1-AR and caveolin.Caveolin-3, the alpha1-adrenergic receptor, Gq and PLC-beta subtypes (PLC-beta1, -beta3) were found exclusively in the caveolar fraction in the above tissues. Caveolin-3 were co-immunoprecipitated with alpha1-adrenergic receptor and Gq from the cardiac tissues. The amount of caveolin subtypes expression (caveolin-1 and -3) and the amount of the alpha1-adrenergic receptor were examined in the hearts of SHR and age-matched WKY (4- and 24-weeks-old). The amount of caveolin-3 expression was significantly smaller in SHR at 24-weeks-old than that in SHR at 4-weeks-old and that in WKY at 24-weeks-old.The molecules involved in alpha1-adrenergic signaling are confined to the same microdomain as caveolin. A decrease in caveolin-3 expression may play a role in the development of cardiac hypertrophy in SHR, presumably through de-regulating the inhibition of growth signal in the hearts of SHR in the hypertrophic stage.
1275 IMPORTANCE OF THE CHEMOKINE RANTES (CCL5) FOR FATTY LIVER DISEASE AND OBESITY IN MICE
Authors: A. Nellen, M. Moreno Zaldivar, P. Schmitz, D. Heinrichs, M.-L. Berres, C. Weber, C. Trautwein, H.E. Wasmuth
Journal: Journal of Hepatology (2011)
Canadian academics call for asbestos report to be published
Authors: David Spurgeon
Journal: BMJ (2008)

The chairman and another member of a panel of seven international experts engaged by Canada’s federal health department to examine risks of cancer associated with asbestos have complained to the health minister, Tony Clement, about delays in publicly releasing the panel’s report.

They say that the delay is occurring at a time when “erroneous allegations” have been made about the report by those who have seen it “to suit their political objectives,” a reference to a statement in the House of Commons by Andre Bellavance, MP for Richmond-Arthabaska, Bloc Quebecois. The report looks at risks from a form of asbestos that Canada promotes worldwide.

Trevor Ogden, the panel’s chairman, and his colleague Leslie Stayner, director …
An Open House
Authors: Neil Skolnik
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Role of thromboxane A2 in the cardiovascular response to intracoronary C5a.
Authors: G L Stahl, E A Amsterdam, J D Symons, J C Longhurst
Journal: Circulation Research (1990)

Intracoronary administration of complement component C5a induces transient decreases in coronary blood flow and regional left ventricular segment shortening, associated with intramyocardial granulocyte trapping. We evaluated the influence of a cyclooxygenase inhibitor (acetylsalicylic acid, n = 8) or a thromboxane A2/prostaglandin H2 receptor antagonist (SQ29548, n = 6) on these C5a-induced cardiovascular responses. Open-chest anesthetized pigs were instrumented to monitor heart rate, arterial blood pressure, left anterior descending coronary blood flow, regional left ventricular segment shortening, and dP/dt. Oxygen content, lactate concentration, leukocyte count, and thromboxane B2, the stable metabolite of thromboxane A2, were measured in arterial and regional coronary venous blood. Repetitive injections of intracoronary C5a (500 ng) given 60 minutes apart showed no tachyphylaxis of the hemodynamic response. However, tachyphylaxis was seen in coronary blood flow changes when injections were spaced 30 minutes apart. An increase in myocardial oxygen extraction and lactate production was observed after intracoronary C5a. Administration of acetylsalicylic acid (50 mg/kg i.v.) attenuated C5a-induced decreases in coronary blood flow (-8 +/- vs. -3 +/- 1 ml/min) and regional left ventricular segmental shortening (-10 +/- 3% vs. -2 +/- 1%) and blocked the maximal increase in coronary venous thromboxane B2 (2.0 +/- 0.1 vs. 0.2 +/- 0.1 pmol/ml plasma). Furthermore, SQ29548 (30 micrograms/kg/min) reduced C5a-induced changes in coronary blood flow (-13 +/- 2 vs. -4 +/- 2 ml/min) and segmental shortening (-14 +/- 2% vs. -3 +/- 1%). Neither cyclooxygenase inhibition nor thromboxane A2/prostaglandin H2 antagonism blocked the decrease in coronary venous granulocyte count.(ABSTRACT TRUNCATED AT 250 WORDS)
Prognosis of patients with hepatocellular carcinoma (HCC) according to okuda staging system, clip staging system and BCLC staging classification: results of a single italian centre
Authors: G. Caminiti, M. Pompili, M. Covino, B. Alfei, L. Miele, G.L. Rapaccini, A. Grieco, G. Gasbarrini
Journal: Journal of Hepatology (2003)
Predictive factors of HCV recurrence after liver transplantation (OLTX)
Authors: S. Pevere, S. Boninsegna, D. Martines, U. Cillo, P. Burra, P. Boccagni, G. Zanus, D.F. D'Amico, R. Naccarato, S. Fagiuoli
Journal: Journal of Hepatology (2003)
Lost in Translation
Authors: Leonard A. Levin, Helen V. Danesh-Meyer
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cardiovascular Effects of Mechanical Ventilation and Positive End-Expiratory Pressure-Reply
Authors: John M. Luce
Journal: JAMA (1985)

In Reply.—  I appreciate the interest of Drs L'Hommedieu and Farrell in my recent review of the cardiovascular effects of MV and PEEP. They are correct in noting that MV and PEEP do not necessarily increase right ventricular afterload in all patients and that such afterload actually may decrease if MV and PEEP are used effectively. Nevertheless, MV and PEEP may be harmful if used ineffectively, as I tried to stress in my review.
The Role of Ammonia Production and Excretion in Regulation of Acid-Base Balance
Authors: Robert F. Pitts
Journal: New England Journal of Medicine (1971)

THE reaction of the extracellular fluid of normal man is stabilized within narrow limits of pH 7.35 and 7.45. The carbonic acid-bicarbonate buffer system has the key role in stabilizing hydrogen ion concentration within these limits. The importance of this buffer system does not derive from the fact that it is an especially effective one at the pH of body fluids. Indeed it is not, for its dissociation constant is too far removed from the hydrogen ion concentration of these fluids for optimum stabilization of reaction. Rather, the importance of this buffer system is that its two components are regulated . . .
A Leaf From an Old Book.
Authors: Henry O. Smith
Journal: JAMA (1898)

Hudson Center, N. H., Aug. 15, 1898. <h3>To the Editor:</h3> —There has recently come into my possession a book the title of which reads as follows: "Medicina Magica tamen Physica: Magical but Natural Physick, or a Methodical Tractate of Diastatical Physick. Containing the general Cures of all infirmities. With a Description of a most excellent Cordial out of Gold much to be estimated. Published by Samuel Boulton, Salop, London. Printed by T. C. for N. Brook at the Angel in Cornhill, 1665." The book is inscribed to the "Marquess of Dorchester," by Samuel Boulton, under date of 1646. In these days of various "gold" treatments it may be of interest to become acquainted with methods employed 250 years ago. To quote our author: "Put foliated gold into a vessel well sealed with<i>Hermes</i>seal; put it into our fire till it be calcined to ashes; then sublime it into flores,
Impact of long-term acyclovir on cytomegalovirus infection and survival after allogeneic bone marrow transplantation
Authors: H.G. Prentice, E. Gluckman, R. Powles, P. Ljungman, N.J. Milpied, J.M. Fernandez-Rañada, F. Mandelli, P. Kho, A.R. Bell, L. Kennedy
Journal: The Lancet (1994)
ADHD: Braun et al. Respond
Authors: Joe M. Braun, Bruce P. Lanphear, Robert S. Kahn, Tanya Froehlich, Peggy Auinger
Journal: Environmental Health Perspectives (2007)

ADHD in those subjects with low ferritin levels.Given that lead exposure may contribute to ADHD and iron deficiency may exacerbate deleterious effects caused by lead, we recommend systematically seeking for iron deficiency in children with ADHD.We also think that controlled studies assessing the potential effectiveness of iron supplementation on ADHD symptoms should be encouraged.Such studies could aid the understanding of the complex pathophysiology underlying ADHD and provide effective therapeutic strategies for this disorder.
Autologous and Allogeneic Stem-Cell Transplantation for Transformed Chronic Lymphocytic Leukemia (Richter's Syndrome): A Retrospective Analysis From the Chronic Lymphocytic Leukemia Subcommittee of the Chronic Leukemia Working Party and Lymphoma Working Party of the European Group for Blood and Marrow Transplantation
Authors: Kate Cwynarski, Anja van Biezen, Liesbeth de Wreede, Stephan Stilgenbauer, Donald Bunjes, Bernd Metzner, Vladimir Koza, Mohamad Mohty, Kari Remes, Nigel Russell, Arnon Nagler, Marijke Scholten, Theo de Witte, Anna Sureda, Peter Dreger
Journal: Journal of Clinical Oncology (2012)

Patients with Richter's syndrome (RS) have a poor prognosis with conventional chemotherapy. The aim of this study was to evaluate the outcome after autologous stem-cell transplantation (autoSCT) or allogeneic stem-cell transplantation (alloSCT) in RS.A survey was sent to all European Group for Blood and Marrow Transplantation centers assessing transplantations performed for RS. Eligibility criteria included a diagnosis of RS or secondary lymphoma before SCT, age ≥ 18 years, and SCT performed from 1997 to 2007. Data were analyzed by descriptive statistics and methods from survival analysis.Fifty-nine patients were registered. Thirty-four patients had received autoSCT, mostly because of chemotherapy-sensitive disease, and 25 had received alloSCT, with 36% being refractory to chemotherapy at SCT. In 18 allograft recipients (72%), reduced-intensity conditioning (RIC) was used. Three-year estimates of the probabilities of overall survival and relapse-free survival (RFS) and the cumulative incidences of relapse and nonrelapse mortality were 36%, 27%, 47%, and 26% for alloSCT and 59%, 45%, 43%, and 12% for autoSCT, respectively. Taking into account the limitations set by the low number of events and age younger than 60 years, chemotherapy-sensitive disease and RIC were found to be associated with superior RFS after alloSCT in multivariate analysis. Factors with a significant impact on autoSCT could not be identified.Patients with RS who are sensitive to induction chemotherapy appear to benefit from consolidation with transplantation strategies, and prolonged survival was observed in a proportion of patients.
Operative Surgery and Management
Authors: Ben Eiseman
Journal: JAMA (1982)

According to the introduction and dust cover, this large (861-page) book is intended to help young surgeon trainees pass their first qualifying examination in the United Kingdom. The 54 chapters cover abdominal, thoracic, and cardiac surgery as well as gynecology, neurosurgery, and transplantation, as they are of interest to general surgeons. The authors are 54 clinical surgeons, most of whom are consultants in practice in the south and southwestern part of England around Bristol. Their sound clinical background imparts the tone of the volume. It is as though most clinicians say to a medical student or very junior houseman (intern), "This, my boy, is what you should know about the case we are operating tomorrow—on which you will be holding retractors." Although the general design of the volume is as an atlas of operative surgery, technique is not explained in the detail often sought by a qualified surgeon. This is
Accumulation and assembly of myosin in hypertrophic cardiomyopathy with the 403 Arg to Gln beta-myosin heavy chain mutation.
Authors: T Vybiral, P R Deitiker, R Roberts, H F Epstein
Journal: Circulation Research (1992)

The sarcomeric proteins and organization of cardiac myofibrils appeared intact in multiple unrelated patients with hypertrophic cardiomyopathy. In two subjects demonstrating the missense mutation at position 403 (Arg to Gln) in the beta-myosin heavy chain gene, total myosin and immunoreactive beta-myosin heavy chain levels were similar to those found in other patients with hypertrophic cardiomyopathy and various disease control subjects. No alteration in expression of the cardiac alpha-myosin heavy chain gene was observed. These results are consistent with the examined myosin heavy chain mutation, permitting proper accumulation and assembly of myosin while primarily impairing contractile function. The characteristic myocyte disarray would appear likely to be a secondary consequence of the mutations.
Double dummy trials
Authors: P. Sedgwick
Journal: BMJ (2011)

Researchers evaluated the efficacy of quetiapine and of rivastigmine in the treatment of agitation in people with dementia in institutional care. Little research had been undertaken in the use of these drugs to treat this condition. A randomised, double blind, double dummy, placebo controlled trial was performed.1 The outcome measures included agitation and cognitive performance at baseline, at six weeks, and at 26 weeks. A total of 93 patients were randomised to quetiapine, rivastigmine, or placebo.

The researchers reported that, when compared with placebo, neither quetiapine nor rivastigmine was effective …
Coronary Bypass Grafting
Authors: R. Hole
Journal: BMJ (1972)

The men concerned had received multiple injections of analgesics and antihistamines with consequent haematoma formation in the gluteal and lateral thigh musculature.With the exception of small volume injections during immunization, intramuscular therapy is usually unnecessary and always dangerous in patients with coagulation de- fects.The consequent haemorrhage not only causes pain and pressure on surrounding tissues, but may result in muscle fibrosis and permanent crippling.-I am, etc.,