Nitrofurantoin and Chronic Active Hepatitis
Authors: KEITH G. TOLMAN
Journal: Annals of Internal Medicine (1980)

Editorials1 January 1980Nitrofurantoin and Chronic Active HepatitisKEITH G. TOLMAN, M.D.KEITH G. TOLMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-92-1-119 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptNitrofurantoin is a furan derivative commonly used as a urinary tract antiseptic. It is estimated that approximately 5 million courses of nitrofurantoin or one of its analogs are given yearly in the United States and Canada (Personal communication, Norwich-Eaton Pharmaceuticals, Norwich, New York). Many different side-effects, including fever, leukopenia, hemolytic anemia, pulmonary fibrosis, peripheral neuropathy and cholestatic jaundice have been described. The reports by Black and associates (1) and Sharp and associates (2) in this issue focus on the previously rarely recognized syndrome of nitrofurantoin-induced chronic active hepatitis. Proof of drug-induced injury has been obtained by the ultimate test of...References1. BLACKRABINSCHATZ MLN. Nitrofurantoin-induced chronic active hepatitis. Ann Intern Med. 1980;92:62-4. LinkGoogle Scholar2. SHARPISHAKZIMMERMAN JKH. Chronic active hepatitis and severe hepatic necrosis associated with nitrofurantoin. Ann Intern Med. 1980;92:14-19. LinkGoogle Scholar3. SELROOSEDGREN OJ. Lupus-like syndrome associated with pulmonary reaction to nitrofurantoin. Acta Med Scand. 1975;197:125-8. CrossrefMedlineGoogle Scholar4. HATOFFCOHENSCHWEIGERTTALBOT DMBW. Nitrofurantoin: another cause of drug-induced chronic active hepatitis. Am J Med. 1979;87:117-21. CrossrefGoogle Scholar5. LINDBERGLINDHOLMIWARSON JAS. Genetic factors in the development of chronic active hepatitis. Lancet. 1977;1:67-8. CrossrefMedlineGoogle Scholar6. GALBRAITHEDDLESTONWILLIAMS RAR. Enhanced antibody responses in active chronic hepatitis: relation to HLA-B8 and HLA-B12 and porto-systemic shunting. Lancet. 1976;1:930-4. CrossrefMedlineGoogle Scholar7. OLIVEMCCALLA PD. Cytotoxicity and DNA damage to mammalian cells by nitrofurans. Chem Bio Interact. 1977;16:223-33. CrossrefMedlineGoogle Scholar8. HORIUCHIOHTSUBOSAITO TKM. Furylfuramide-induced hepatic necrosis in mice and its modification by phenobarbital. Japan J Exp Med. 1976;46:111-21. MedlineGoogle Scholar9. MITCHELLPOTTERJOLLOW JWD. Massive hepatic necrosis caused by furosemide. Nature. (London) 1974;251:508-11. CrossrefMedlineGoogle Scholar10. MITCHELLJOLLOW JD. Metabolic activation of drugs to toxic substances. Gastroenterology. 1975;68:392-410. CrossrefMedlineGoogle Scholar11. SWENSONMILLERMILLER DJE. 2, 3-dihydro-2,3-dihydroxyaflatoxin B1 an acid hydrolysis product of an RNA-aflatoxin B1 adduct formed by hamster and rat liver microsomes in vitro. Biochem Biophys Res Commun. 1973;53:1260-7. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Utah College of Medicine Salt Lake City, Utah PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByElectron Deficiency of Nitro Group Determines Hepatic Cytotoxicity of NitrofurantoinOxidative bioactivation of nitrofurantoin in rat liver microsomesMetabolic Activation and Toxicities of FuranoterpenoidsDRUG-INDUCED CHRONIC LIVER DISEASELes hépatites chroniques actives médicamenteusesNitrofurantoinDisposition of Nitrofurantoin and Nitrofurazone in the Isolated Perfused Rat KidneyOral Antimicrobial DrugsNitrofurantoin and Chronic Active HepatitisALASTAIR R.O. MILLER, R.N., BRUCE J. ADDIS, R.N., PAUL D. CLARKE, R.N.Diagnostic Imaging of Focal Nodular Hyperplasia of the Liver Developing during Nitrofurantoin TherapyDrug-Induced Chronic HepatitisMiscellaneous antibacterial and antiviral drugsDrug-induced chronic hepatitis 1 January 1980Volume 92, Issue 1Page: 119-120KeywordsChronic hepatitisDrugsFeversHemolytic anemiaHepatitis APeripheral neuropathyPulmonary fibrosis Issue Published: 1 January 1980 Copyright©1980 American College of PhysiciansPDF DownloadLoading ...