tbuckley/cabot-search huggingface dataset:
Effects of nifedipine on coronary hemodynamic findings during exercise in patients with stable exertional angina.
Authors: G Specchia, S de Servi, C Falcone, L Angoli, A Gavazzi, E Bramucci, A Mussini, M Ferrario, J Salerno, C Montemartini
Journal: Circulation (1983)

To investigate the mechanism by which nifedipine improves exercise tolerance in patients with coronary artery disease, we studied 14 patients with stable exertional angina and left anterior descending artery disease by measuring great cardiac vein flow (GCVF) and calculating anterior regional coronary resistance (ARCR) during exercise before and after sublingual administration of 20 mg of nifedipine. After nifedipine seven patients (group I) had no increase in exercise capacity and showed a similar magnitude of ST segment depression at peak exercise, while another seven patients (group II) had prolonged exercise duration (p less than .001) with less ST segment depression at peak exercise (p less than .01). Such effects were achieved despite a significant increase in double product, an indirect index of myocardial oxygen consumption. In group I patients no significant change was induced by nifedipine in GCVF or in ARCR either at rest or at peak exercise. In contrast, in group II patients nifedipine significantly increased GCVF at rest (p less than .05) and at peak exercise (p less than .001). Moreover, resting ARCR was decreased (p less than .01) and remained significantly lower at peak exercise (p less than .01) compared with the prenifedipine values. These data show that nifedipine may increase GCVF and decrease ARCR at rest and at peak exercise in patients with left anterior descending artery disease. Such increase in myocardial oxygen supply seems the most likely mechanism by which nifedipine may improve exercise capacity in patients with stable exertional angina.
Delivery of Mother and Child
Authors: Harry L. Arnold
Journal: JAMA (1962)

<h3>To the Editor:—</h3> With reference to the "delivery" of babies (<i>JAMA</i><b>178</b>:782 [Nov. 18] 1961), not even Dr. Fishbein, with or without dictionary support, can stop doctors from delivering babies. They do it all the time. Any dictionary that doesn't say that "deliver" means, among other things, "assist at the birth of [a baby or a person]," has just not completely defined the word. My grandfather delivered Thomas E. Dewey. He also delivered Mr. Dewey's mother. The second statement is far less interesting and informative than the first. It is not one bit more "correct." Usage is the determinant, not the dictionary.
Understanding action with the motor system
Authors: Vittorio Gallese, Corrado Sinigaglia
Journal: Behavioral and Brain Sciences (2014)

We challenge Cook et al.'s claim about the vagueness of the notion of action understanding in relation with mirror neurons. We show the multidimensional nature of action understanding and provide a definition of motor-based action understanding, shedding new light on the various components of action understanding and on their relationship. Finally, we propose an alternative perspective on the origin of mirror neurons, stressing the necessity to abandon the dichotomy between genetic and associative hypotheses.
IMPACT OF MITRAL REGURGITATION ON CLINICAL OUTCOME AFTER TRANSCATHETER AORTIC VALVE IMPLANTATION
Authors: Sung-Han Yoon, Jung-Min Ahn, Young-Hak Kim, Cheol Whan Lee, Jeong Yoon Jang, Jae-Hyung Roh, Pil Hyung Lee, Hyun Kuk Kim, Hanul Choi, Dong Hyun Yang, Jong-Young Lee, Joon-Won Kang, Soo-Jin Kang, Duk-Woo Park, Seung-Whan Lee, Jong-Min Song, Seong-Wook Park, Seung-Jung Park
Journal: Journal of the American College of Cardiology (2014)
Allocating Livers — Devising a Fair System
Authors: Robert Steinbrook
Journal: New England Journal of Medicine (1997)

Because there is a wide gap in the United States between the number of patients on waiting lists for organ transplants and the number of organs available for transplantation, any system of allocation is likely to seem inequitable from the viewpoint of patients who may die while waiting for an organ to become available. A lottery might seem better but abdicates responsibility. The limited number of organs can be provided to the maximal number of beneficiaries only through a coherent and efficient system. The choices are difficult — for example, whether to assign the highest priority to the sickest patients . . .
Sensitization to house dust mites in Reykjavik, Iceland, in the absence of domestic exposure to mites
Authors: T. E. Hallas, D. Gislason, U. S. Björnsdottir, K. B. Jörundsdottir, C. Janson, C. M. Luczynska, T. Gislason
Journal: Allergy (2004)

House dust mites are common sources of indoor allergens. In Reykjavik, Iceland, 9% of the young adult population had serum-specific IgE to Dermatophagoides pteronyssinus. Sensitization to mites is usually assumed to be due to exposure to house dust mites in the indoor environment. This investigation was carried out to measure the concentrations of house dust mite allergens and to investigate which species of mites were present in beds in Iceland.A total of 197 randomly selected adults were visited at home using the European Community Respiratory Health Survey (ECRHS) II Indoor protocol. Dust samples were collected from mattresses for measurement of house dust mite allergen concentrations and to estimate the number and type of house dust mites. Additional samples from mattresses and floors were collected from the homes of 10 patients with positive skin prick tests (SPT) to D. pteronyssinus. House dust mite allergen concentrations were measured using ELISA and examination of mite species was carried out using microscopy. Climatic parameters were assessed using psychrometer readings in the bedrooms and outdoors.We found two single mite specimens, both D. pteronyssinus, in two dust samples. Mite allergen analyses indicated that two other dust samples had Der f 1 results close to the cut-off of 0.1 microg/g of dust. No samples were positive for Der p 1. In an additional collection of dust from the homes of 10 SPT-positive patients no Dermatophagoides spp. were found.Reykjavik citizens are exposed to extremely low amounts of house dust mite allergens in their homes. Possible alternative sources for sensitization are discussed, such as bird nests, exposure from travelling abroad, or other mites or invertebrates that cross-react with house dust mite allergens. Our findings suggest that exposures other than to house dust mites indoors are possible sources of mite allergen exposure.
Time Course of Diastolic and Systolic Function Improvement After Pulmonary Valve Replacement in Adult Patients With Tetralogy of Fallot
Authors: Alexander van Straten, Hubert W. Vliegen, Hildo J. Lamb, Stijntje D. Roes, Ernst E. van der Wall, Mark G. Hazekamp, Albert de Roos
Journal: Journal of the American College of Cardiology (2005)
The increase in surface CXCR4 expression on lung extravascular neutrophils and its effects on neutrophils during endotoxin-induced lung injury
Authors: Mitsuhiro Yamada, Hiroshi Kubo, Seiichi Kobayashi, Kota Ishizawa, Mei He, Takaya Suzuki, Naoya Fujino, Hiroyuki Kunishima, Masamitsu Hatta, Katsushi Nishimaki, Tetsuji Aoyagi, Kouichi Tokuda, Miho Kitagawa, Hisakazu Yano, Hirokazu Tamamura, Nobutaka Fujii, Mitsuo Kaku
Journal: Cellular and Molecular Immunology (2011)
The primary/secondary distinction of psychopathy: A clinical perspective
Authors: Gisli H. Gudjonsson
Journal: Behavioral and Brain Sciences (1995)

Abstract In this brief commentary the author concentrates on the treatment perspectives of Mealey's model. The main weakness of the model is that it does not provide a satisfactory theoretical connection between treatment and different types of target behavior. Even within the primary-secondary distinction, there are large individual differences that should not be overlooked in the planning of treatment.
Incidence of mortality and morbidity related to postoperative lung injury in patients who have undergone abdominal or thoracic surgery: a systematic review and meta-analysis
Authors: Ary Serpa Neto, Sabrine NT Hemmes, Carmen SV Barbas, Martin Beiderlinden, Ana Fernandez-Bustamante, Emmanuel Futier, Markus W Hollmann, Samir Jaber, Alf Kozian, Marc Licker, Wen-Qian Lin, Pierre Moine, Federica Scavonetto, Thomas Schilling, Gabriele Selmo, Paolo Severgnini, Juraj Sprung, Tanja Treschan, Carmen Unzueta, Toby N Weingarten, Esther K Wolthuis, Hermann Wrigge, Marcelo Gama de Abreu, Paolo Pelosi, Marcus J Schultz
Journal: The Lancet Respiratory Medicine (2014)
A Growing Network of Cancer-Susceptibility Genes
Authors: Ashok R. Venkitaraman
Journal: New England Journal of Medicine (2003)

Over the past couple of years, there has been a surge in the rate of discovery of proteins that interact with the products of the breast-cancer–susceptibility genes BRCA1 and BRCA2. Several findings link the BRCA proteins and proteins that are mutant in Fanconi's anemia. This link provides not only a more detailed picture of how DNA is repaired, but also strategic targets for experimental therapies.
505. Advances in Large-Scale Production of Recombinant Adeno-Associated Vectors
Authors: Alejandro Negrete, Masashi Urabe Urabe, Robert M. Kotin
Journal: Molecular Therapy (2006)

Recombinant adeno-associated viral vectors (rAAV) are one of the most promising vectors for human gene therapy due to their long term transduction of mitotic and post-mitotic cells. In our laboratory, a novel technology for the production of rAAV has been developed. This method consists of producing rAAV in insect cells using baculovirus expression vectors. This invertebrate cell production system greatly facilitates the production and development of rAAV-based therapeutics. Although this insect cell-based production system has the potential to alleviate one of the bottlenecks in the manufacturing of rAAV, the practical aspects of large-scale production and processing of vector remains unresolved.
The Qualitative Platelet Defect in Chronic Renal Insufficiency.
Authors: C. L. Lutcher
Journal: Annals of Internal Medicine (1968)

s1 May 1968The Qualitative Platelet Defect in Chronic Renal Insufficiency.C. L. Lutcher, M.D., G. A. Porter, M.D., A. J. Seaman, M.D., F.A.C.P.C. L. Lutcher, M.D.Search for more papers by this author, G. A. Porter, M.D.Search for more papers by this author, A. J. Seaman, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-5-1170_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA qualitative platelet abnormality exists in certain patients with renal failure. We studied this phenomenon in five patients with bleeding due to severe chronic renal insufficiency. The defect was characterized by a prolonged Ivy bleeding time and decreased prothrombin consumption in all five patients. Other routine coagulation studies were normal. Intravascular observations using blood from these patients to perfuse the living extracorporeal eye (Arch. Intern. Med. (Chicago) 119: 600, 1967) were made. Most significant was the failure to form platelet aggregates upon the addition of adenosine diphosphate to their blood.Ivy bleeding times and prothrombin consumption tests remained abnormal in... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Portland, Oregon PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1968Volume 68, Issue 5Page: 1170-1170KeywordsAdenosine diphosphateBloodHemorrhagePlateletsRenal failure ePublished: 1 December 2008 Issue Published: 1 May 1968 PDF downloadLoading ...
Estrogen Therapy for Bleeding Gastrointestinal Telangiectasias
Authors: DON BRINBERG
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 September 1986Estrogen Therapy for Bleeding Gastrointestinal TelangiectasiasDON BRINBERG, M.D., PETER H. R. GREEN, M.D., OSCAR LEBWOHL, M.D.DON BRINBERG, M.D.Search for more papers by this author, PETER H. R. GREEN, M.D.Search for more papers by this author, OSCAR LEBWOHL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-105-3-462_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Angiodysplasia (or telangiectasia) is a recognized cause of gastrointestinal bleeding seen in up to 23% of patients with chronic renal failure (1) and 6. 6% of patients evaluated for rectal bleeding (2). Treatments for angiodysplastic lesions have included surgery, electrocautery, and laser and angiographic obliteration. We present a case of a patient who received estrogen-progestogen therapy for recurrrent gastrointestinal bleeding from angiodysplastic lesions.A 72-year-old woman presented with melena in 1979. Evaluation included an upper gastrointestinal series, barium enema, panendoscopy, and colonoscopy. These studies revealed multiple angiodysplasias in her stomach, duodenum, and colon. Her medical history included...References1. ZUCKERMANCORNETTECLOUSEHARTER GGRH. Upper gastrointestinal bleeding in patients with chronic renal failure. Ann Intern Med. 1985;102:588-92. LinkGoogle Scholar2. TEDESCOWAYERASKINMORRISGREENWALD FJJSR. Colonoscopic evaluation of rectal bleeding. Ann Intern Med. 1978;89:907-9. LinkGoogle Scholar3. KOCHESCHER HG. Hormonal management of hereditary hemorrhagic telangiectasia JAMA. 1952;149:1376-80. CrossrefMedlineGoogle Scholar4. MCGEE R. Estrogen-progesterone therapy for gastrointestinal bleeding in hereditary hemorrhagic telangiectasias. South J Med. 1979;72:1503. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Columbia-Presbyterian Medical Center New York, NY 10032 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1986Volume 105, Issue 3Page: 462-463KeywordsColonColonoscopyDuodenumEstrogensHemorrhageLesionsRenal failureStomachSurgery Issue Published: 1 September 1986 PDF downloadLoading ...
Severe thrombocytopenia in patients treated with suramin: Evidence for an immune mechanism in one
Authors: John F. Tisdale, William D. Figg, Eddie Reed, Natalie A. McCall, Brenda R. Alkins, McDonald K. Horne
Journal: American Journal of Hematology (1996)

Although suramin has long been used to treat human trypanosomiasis, recent clinical trials have tested its efficacy against the acquired immunodeficiency syndrome (AIDS) and various malignancies. Thrombocytopenia was observed in early trials with suramin in AIDS, but has been uncommon in patients treated for solid tumors. Here we describe 5 patients out of a total of 67 (7%) who developed severe thrombocytopenia while receiving suramin as part of a phase II clinical trial for metastatic prostate carcinoma refractory to hormonal therapy. IgG purified from one patient's plasma caused suramin-dependent platelet aggregation. There was also evidence of crossreactivity between suramin and heparin in this system. An immune mechanism, however, could not be documented in the other cases, suggesting that multiple mechanisms may be responsible for severe thrombocytopenia in this patient population. (This article is a US Government work and, as such, is in the public domain in the United States of America.) © 1996 Wiley-Liss, Inc.
A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura
Authors: Ronald G Lafrenière, M Zameel Cader, Jean-François Poulin, Isabelle Andres-Enguix, Maryse Simoneau, Namrata Gupta, Karine Boisvert, François Lafrenière, Shannon McLaughlan, Marie-Pierre Dubé, Martin M Marcinkiewicz, Sreeram Ramagopalan, Olaf Ansorge, Bernard Brais, Jorge Sequeiros, Jose Maria Pereira-Monteiro, Lyn R Griffiths, Stephen J Tucker, George Ebers, Guy A Rouleau
Journal: Nature Medicine (2010)
Metabolism and effects on platelet function of the purified eicosapentaenoic and docosahexaenoic acids in humans.
Authors: C von Schacky, P C Weber
Journal: Journal of Clinical Investigation (1985)

Metabolism and effects on platelet function of 6 g/d for 6 d of either eicosapentaenoic acid (EPA, C20:5 omega-3) or docosahexaenoic acid (DCHA, C22:6 omega-3) in volunteers were compared in a randomized crossover study. Incorporation kinetics revealed that EPA appeared in plasma free fatty acids and plasma phospholipids after 4 h, but was not incorporated into platelet phosphatidylcholine and -ethanolamine until day 6. This indicates that platelet fatty acid composition does not immediately reflect that of the surrounding plasma milieu, but rather may be determined during megakaryocyte maturation. Importantly, EPA was not incorporated into platelet phosphatidylinositol or -serine in vivo, thus reflecting selective biosynthesis of platelet phospholipids. After dietary EPA, C22:5 omega-3 increased in plasma and platelet phospholipids. In contrast, DCHA-levels were unaltered. After DCHA-ingestion, C20:5 omega-3 concentrations rose in plasma phospholipids, implying that retroconversion took place. These findings indicate that dietary DCHA can serve as a source of EPA. During this short-term study, ingestion of both EPA and DCHA resulted in reduced platelet aggregation in response to collagen. The response to ADP was lowered significantly only by DCHA. After either EPA or DCHA, thromboxane formation was unchanged in serum derived from clotted whole blood as was total in vivo synthesis measured by excretion of immunoreactive 2,3-dinor thromboxane B2/3. We conclude that DCHA reduces platelet responsiveness, contributing to the antithrombotic effects of omega-3 fatty acid-rich fish oil ingestion, of which DCHA is a major component.
906-65 Use of Color-coded Tissue Doppler for Dobutamine-Stress-Echocardiography
Authors: Thomas Buck, Jaroslaw Drozdz, Frank Schön, Roman Leischik, Dietrich Baumgart, Junbo Ge, Günter Görge, Michael Haude, Raimund Erbel
Journal: Journal of the American College of Cardiology (1995)
Left and right sided large bowel cancer
Authors: S. Richman
Journal: BMJ (2002)

Cancer of the large bowel is the third commonest cancer, and second commonest cause of death due to cancer in the United Kingdom. In 1994, there were 28 904 registered new cases and about 15 740 deaths from colorectal cancer in England and Wales.1 Differences in clinical presentation and surgical management of right and left sided large bowel cancer are well known. For example, right sided tumours typically present at a more advanced stage with symptoms of weight loss and anaemia, whereas left sided tumours often present with rectal bleeding, change in bowel habit, and tenesmus. However, we are now aware of increasing differences in the molecular pathology of carcinomas depending on their laterality within the large bowel. These differences will become more relevant as systemic treatments improve.

The large bowel includes both the colon and the rectum. It is continuous, with no definite point microscopically where colon ends and rectum begins. From an anatomical and surgical point of …
More Blood for Sickle Cell Anemia?
Authors: Martin H. Steinberg
Journal: New England Journal of Medicine (2014)

The clinical features of sickle cell anemia are caused by polymerization of deoxygenated sickle hemoglobin (hemoglobin S), the predominant hemoglobin type found in this genetic disease. Sickle polymer damages the red cell, shortens its life span, and triggers vascular occlusive disease. Among the vascular complications of sickle cell anemia is stroke, which affects about 10% of children who do not undergo long-term blood-transfusion therapy after transcranial Doppler screening. Stroke is accompanied by high cerebral blood-flow velocity, which is associated with endothelial damage, intracranial and extracranial cerebral vascular occlusion, and intracerebral hemorrhage. Blood transfusion reduces the velocity of cerebral blood flow . . .
Early non-radiological recognition of misplacement of central venous catheters
Authors: B R H Doran
Journal: BMJ (1983)

positive in the other 109 cases.The test may also be used to reposition catheters.2Though cranial deviation of a guidewire may indicate misplacement, the combination of head turning and supraclavicular pressure should prevent this complication, and any malpositions may be detected with the ausculatory test.In a subsequent consecutive series of 100 infraclavicular catheterisations I have used the head turning manoeuvre and the auscula- tory test, all catheters being correctly positioned before chest x ray examination.
Cardiac Overexpression of the Norepinephrine Transporter Uptake-1 Results in Marked Improvement of Heart Failure
Authors: Götz Münch, Kai Rosport, Andreas Bültmann, Christine Baumgartner, Zhongmin Li, Lien Laacke, Martin Ungerer
Journal: Circulation Research (2005)

A hyperadrenergic state is one of the key features of human and experimental heart failure. Decreased densities and activities of the presynaptic neuronal norepinephrine (NE) transporter uptake-1 occur both in patients and animal models. It is currently unclear to what extent the reduction of uptake-1 contributes to the deterioration of heart failure. Therefore, we investigated the effects of myocardial overexpression of uptake-1 in both nonfailing rabbit hearts and in an animal model of heart failure. Heart failure was induced in rabbits by rapid ventricular pacing. Adenoviral gene transfer was used to overexpress uptake-1 in the myocardium. Uptake-1 overexpression led to increased NE uptake capacity into the myocardium. In contrast, systemic plasma NE levels in uptake-1-overexpressing failing rabbits (uptake-1–CHF) did not differ from controls. Downregulation of SERCA-2 and β-adrenergic receptors in the failing myocardium was significantly reversed after uptake-1 overexpression. Uptake-1 overexpression significantly improved left ventricular (LV) diameters (LV end-diastolic diameter: in GCP-overexpressing failing rabbits (GFP-CHF), 17.4±0.4 mm; in uptake-1–CHF rabbits, 15.6±0.6 mm) and systolic contractility (fractional shortening: GFP-CHF, 20.7±0.6%; uptake-1–CHF, 27.3±0.7%), as assessed by echocardiography at the end of the heart failure protocol. Intraventricular tip catheter measurements revealed enhanced contractile reserve (dP/dt max with isoproterenol 1.0 μg/kg: GFP-CHF, 6964±230 mm Hg/sec; uptake-1–CHF, 7660±315 mm Hg/sec) and LV relaxation (dP/dt min with isoproterenol 1.0 μg/kg: GFP-CHF: −3960±260 mm Hg/sec; uptake-1–CHF, −4910±490 mm Hg/sec). End-diastolic filling pressures (GFP-CHF, 8.5±1.2 mm Hg; uptake-1–CHF, 5.6±0.7 mm Hg) tended to be lower in uptake-1 overexpressing animals. In summary, local overexpression of uptake-1 in the myocardium results in marked structural and functional improvement of heart failure, thus underlining the importance of uptake-1 as a key protein in heart failure.
CYTOTOXIC FACTORS IN INHIBITION OF LYMPHOCYTE TRANSFORMATION IN LYMPHOMATA
Authors: ANDRZEJ LANGNER, MARIA PAWIŃSKA-PRONIEWSKA, WIESLAW GLIŃSKI, STANISLAW MAJ
Journal: British Journal of Dermatology (2006)

SUMMARY.— The aim of this study was to investigate the mechanism of inhibition of blastic transformation of phytohaemagglutinin-stimulated lymphocytes in malignant lymphoreticular proliferations. Thirty-five untreated cases were examined: 6 reticulosarcoma (RSA), 3 lymphosarcoma (LSA), 7 chronic lymphatic leukaemia (CLL), 8 Hodgkin's disease (HD) and 11 mycosis fungoides (MF). It was demonstrated that the inhibition of transformation of PHA-stimulated lymphocytes in the groups RSA, LSA and Hodgkin's disease depends in a high degree on factors present in the blood plasma of the patients, whereas in the CLL group it is related to lymphocytes, and is not unblocked by using plasma of healthy individuals. In the MF group the decrease in transformation is relatively small and is more pronounced only in patients with extensive lesions in poor general condition.