tbuckley/cabot-search huggingface dataset:
CCL17 Production by Dendritic Cells Is Required for NOD1-mediated Exacerbation of Allergic Asthma
Authors: Saliha Ait Yahia, Imane Azzaoui, Laetitia Everaere, Han Vorng, Cécile Chenivesse, Philippe Marquillies, Catherine Duez, Myriam Delacre, Teddy Grandjean, Joanne Balsamelli, Martine Fanton d'Andon, Ying Fan, Coline Ple, Catherine Werts, Ivo Gomperts Boneca, Benoit Wallaert, Mathias Chamaillard, Anne Tsicopoulos
Journal: American Journal of Respiratory and Critical Care Medicine (2014)

Rationale: Pattern recognition receptors are attractive targets for vaccine adjuvants, and polymorphisms of the innate receptor NOD1 have been associated with allergic asthma.Objectives: To elucidate whether NOD1 agonist may favor allergic asthma in humans through activation of dendritic cells, and to evaluate the mechanisms involved using an in vivo model.Methods: NOD1-primed dendritic cells from allergic and nonallergic donors were characterized in vitro on their phenotype, cytokine secretion, and Th2 polarizing ability. The in vivo relevance was examined in experimental allergic asthma, and the mechanisms were assessed using transfer of NOD1-conditioned dendritic cells from wild-type or CCL17-deficient mice.Measurements and Main Results: NOD1 priming of human dendritic cells promoted a Th2 polarization profile that involved the production of CCL17 and CCL22 in nonallergic subjects but only CCL17 in allergic patients, without requiring allergen costimulation. Moreover, NOD1-primed dendritic cells from allergic donors exhibited enhanced maturation that led to abnormal CCL22 and IL-10 secretion compared with nonallergic donors. In mice, systemic NOD1 ligation exacerbated allergen-induced experimental asthma by amplifying CCL17-mediated Th2 responses in the lung. NOD1-mediated sensitization of purified murine dendritic cells enhanced production of CCL17 and CCL22, but not of thymic stromal lymphopoietin and IL-33, in vitro. Consistently, adoptive transfer of NOD1-conditioned dendritic cells exacerbated the Th2 pulmonary response in a CCL17-dependent manner in vivo.Conclusions: Data from this study unveil a deleterious role of NOD1 in allergic asthma through direct induction of CCL17 by dendritic cells, arguing for a need to address vaccine formulation safety issues related to allergy.
Re: Alberto Briganti, Umberto Capitanio, Felix K.-H. Chun, et al. Impact of Surgical Volume on the Rate of Lymph Node Metastases in Patients Undergoing Radical Prostatectomy and Extended Pelvic Lymph Node Dissection for Clinically Localized Prostate Cancer. Eur Urol 2008;54:794–804
Authors: Tommaso Cai, Gabriella Nesi, Riccardo Bartoletti
Journal: European Urology (2008)
Arthritis, Vasculitis, and Cryoglobulinemia Associated with Relapsing Hepatitis A Virus Infection
Authors: ROBERT D. INMAN
Journal: Annals of Internal Medicine (1986)

Hepatitis A virus, unlike hepatitis B virus, has rarely been associated with extrahepatic features. Two patients developed relapsing hepatitis A complicated by arthritis in both cases and cutaneous vasculitis in one. Both patients had cryoglobulinemia, with cryocrit values of 4.3% and 8.6%. Serologic studies showed that the cryoglobulin consisted of polyclonal IgM and IgG. The washed cryoglobulin was analyzed by sucrose density gradient ultracentrifugation under neutral (pH 7.4) and acidic (pH 2.8) conditions. Enzyme-linked immunosorbent assay techniques were used to characterize the native and dissociated cryoglobulin. The cryoglobulin contained acid-dissociable IgG complexes greater than 19S, and high molecular weight rheumatoid factors of both IgG and IgM isotypes that could be dissociated to 7S and 19S forms, respectively. Dissociation of the cryoglobulin augmented 7S anti-hepatitis A virus IgG 2.27-fold, but augmented total 7S IgG only 1.12-fold, suggesting enrichment of antiviral antibody in the cryoglobulin.
The Hyperactive Cardioinhibitory Carotid-Sinus Reflex as an Aid in the Diagnosis of Coronary Disease
Authors: Louis H. Sigler
Journal: New England Journal of Medicine (1942)

Original Article from The New England Journal of Medicine — The Hyperactive Cardioinhibitory Carotid-Sinus Reflex as an Aid in the Diagnosis of Coronary Disease — Its Value Compared with That of the Electrocardiogram
Nephropathy in NIDDM is Associated With Cellular Markers for Hypertension
Authors: William H Herman, Donna E Prior, May D Yassine, Alan B Weder
Journal: Diabetes Care (1993)

OBJECTIVE To determine if nephropathy in NIDDM is associated with cellular markers for hypertension. RESEARCH DESIGN AND METHODS We compared 11 patients with clinical diabetic nephropathy with 15 control subjects with no diabetic nephropathy. The patients were white and had had NIDDM for &amp;gt; 9 yr and serum creatinine levels &amp;lt; 177 M (2.0 mg/dl). RESULTS Patients with nephropathy were more obese and had higher blood pressures and triglyceride levels, and lower high-density lipoprotein cholesterol levels than control subjects. Erythrocyte sodium lithium countertransport activity, erythrocyte sodium content, and platelet sodium-proton exchange were higher in patients with nephropathy than in control subjects. CONCLUSIONS The results of this small study suggest that in white patients with long-standing NIDDM, diabetic nephropathy is associated with cellular markers for hypertension. Measurement of cellular markers for hypertension may be useful to identify patients who are at risk for developing nephropathy.
Cyclosporin greatly improves the quality of life of adults with severe atopic dermatitis. A randomized, double-blind, placebo-controlled trial
Authors: M.S. SALEK, A.Y. FINLAY, D.K. LUSCOMBE, B.R. ALLEN, J. BERTH-JONES, R.D.R. CAMP, R.A.C. GRAHAM-BROWN, G.K. KHAN, R. MARKS, R.J. MOTLEYJ, J.S. ROSS, J.M. SOWDEN
Journal: British Journal of Dermatology (1993)

A multicentre, randomized, double-blind, controlled crossover clinical trial was conducted on 33 patients with severe refractory atopic dermatitis, to determine the effects of cyclosporin (5 mg/kg/day) on their health-related quality of life. Treatments were administered for 8-week periods. One group (n = 16) received placebo followed by cyclosporin, and the other (n = 17) received cyclosporin and then placebo. Health-related quality of life was assessed at 0, 8 and 16 weeks using a general measure, the United Kingdom Sickness Impact Profile (UKSIP), an eczema-specific measure, the Eczema Disability Index (EDI), and a global 5-point rating scale of overall health (very good to very poor). In addition, clinical assessments (i.e. extent and activity of disease) were made by the investigators. UKSIP and EDI scores indicated significant improvement in quality of life (P < 0.05-P < 0.01) of patients with atopic dermatitis after treatment with cyclosporin. Although no patient required withdrawal from the study, 20 patients receiving cyclosporin reported adverse events, compared with eight taking placebo. There was a close correlation (P < 0.05-P < 0.01) between the UKSIP and EDI scores. In contrast, there was either no correlation, or only a very poor correlation, between the quality of life parameters and clinical measures of extent and activity of eczema. When cyclosporin was stopped, relapse was rapid, but the mean scores for disease activity and extent of disease were less than their baseline values (i.e. an improvement of greater than 25% was maintained in 11 patients at week 4).(ABSTRACT TRUNCATED AT 250 WORDS)
Advances in Preclinical Investigation of Prostate Cancer Gene Therapy
Authors: Marxa L Figueiredo, Chinghai Kao, Lily Wu
Journal: Molecular Therapy (2007)

Treating recurrent prostate cancer poses a great challenge to clinicians. Research efforts in the last decade have shown that adenoviral vector-based gene therapy is a promising approach that could expand the arsenal against prostate cancer. This maturing field is at the stage of being able to translate many preclinical discoveries into clinical practices. At this juncture, it is important to highlight the promising strategies including prostate-targeted gene expression, the use of oncolytic vectors, therapy coupled to reporter gene imaging, and combined treatment modalities. In fact, the early stages of clinical investigation employing combined, multimodal gene therapy focused on loco-regional tumor eradication and showed promising results. Clinicians and scientists should seize the momentum of progress to push forward to improve the therapeutic outcome for the patients.
Assessment of profilin as an allergen for latex‐sensitized patients
Authors: A. Nieto, A. Mazón, M. Boquete, F . Carballada, J. A. Asturias, J Martínez, A. Martínez
Journal: Allergy (2002)

Background: The presence of the actin‐binding protein, profilin, has been demonstrated in natural latex extracts; but the clinical significance of this molecule as an allergen for latex‐allergic patients is not clear. We studied the allergenic relevance of isolated latex natural and recombinant profilin, by in vivo and in vitro techniques, in two populations of spina bifida children (SB) and adults allergic to latex (AL). Methods: Profilin is present in small amounts in latex extracts obtained from low ammoniated (LA) natural latex. Its purification by affinity chromatography resulted difficult due to Heb v 1 unspecific binding. Therefore a method was developed to obtain natural profilin from natural latex, combining affinity chromatography (PLP, poly‐L‐proline Sepharose column) and previous ammonium sulfate fractionation. Alternatively, latex c‐serum containing a low amount of Hev b 1 and a relatively higher profilin content could be used. Recombinant latex profilin isoform (rHev b 8) was cloned by PCR amplification. The entire coding region of Hev b 8 was subcloned into the expression vector pKN172 and a non‐fusion form of Hev b 8 was expressed in Escherichia coli BL21 (DE3). Purified recombinant protein was obtained after a single passage through PLP‐Sepharose column. Results: Natural and recombinant purified Hev b 8 were tested cutaneously by intradermoreaction (ID) in 17 SB and 14 AL patients. They were positive in 15 SB and 14 AL patients. No wheals were produced when tested in nonatopic control patients. Only 42% of sera from latex‐allergic patients revealed specific IgE titers of class 1 or higher by enzyme immunoassay and only 39% of them exhibited IgE binding by SDS‐PAGE immunoblotting with any natural or recombinant Hev b 8 forms. Conclusion: It seems that profilin is a relevant allergen for both groups of patients from a frequency point of view, but with scarce presence in natural latex extracts and raw sources, with a subsequent low IgE induction capacity.
Legionnaires' Disease: Unusual Clinical and Laboratory Features
Authors: RICHARD D. MEYER
Journal: Annals of Internal Medicine (1980)

During a nosocomial epidemic of Legionnaires' disease, clinical and laboratory observations led to the recognition of remarkable aspects in six patients. Features included two episodes of disease, dual or sequential infections with Legionella pneumophila and other pathogens; transient deafness with erythromycin therapy; and Legionnaires' disease with a pleural effusion but no pulmonary infiltrate. Expectorated sputum culture yielded two serogroups of L. pneumophila in one patient. Cultures of transtracheal and endotracheal aspirates and of blood led to the diagnosis, permitted evaluation of confounding potential pathogens, and confirmed Legionnaires' disease in the absence of seroconversion. Although many manifestations of Legionnaires' disease were quite typical in this outbreak, these additional unusual features expand the spectrum and illustrate the value of rapid diagnostic methods.
Impact of Polychlorinated Biphenyls Contamination on Estrogenic Activity in Human Male Serum
Authors: Martina Plíšková, Jan Vondráček, Rocio Fernandez Canton, Jiřií Nera, Anton Kočan, Ján Petrík, Tomáš Trnovec, Thomas Sanderson, Martin van den Berg, Miroslav Machala
Journal: Environmental Health Perspectives (2005)

Polychlorinated biphenyls (PCBs) are thought to cause numerous adverse health effects, but their impact on estrogen signaling is still not fully understood. In the present study, we used the ER-CALUX bioassay to determine estrogenic/antiestrogenic activities of the prevalent PCB congeners and PCB mixtures isolated from human male serum. The samples were collected from residents of an area with an extensive environmental contamination from a former PCB production site as well as from a neighboring background region in eastern Slovakia. We found that the lower-chlorinated PCBs were estrogenic, whereas the prevalent higher-chlorinated PCB congeners 138, 153, 170, 180, 187, 194, 199, and 203, as well as major PCB metabolites, behaved as anti-estrogens. Coplanar PCBs had no direct effect on estrogen receptor (ER) activation in this in vitro model. In human male serum samples, high levels of PCBs were associated with a decreased ER-mediated activity and an increased dioxin-like activity, as determined by the DR-CALUX assay. 17β-Estradiol (E2) was responsible for a major part of estrogenic activity identified in total serum extracts. Significant negative correlations were found between dioxin-like activity, as well as mRNA levels of cytochromes P450 1A1 and 1B1 in lymphocytes, and total estrogenic activity. For sample fractions containing only persistent organic pollutants (POPs), the increased frequency of anti-estrogenic samples was associated with a higher sum of PCBs. This suggests that the prevalent non-dioxin-like PCBs were responsible for the weak antiestrogenic activity of some POPs fractions. Our data also suggest that it might be important to pay attention to direct effects of PCBs on steroid hormone levels in heavily exposed subjects.
Receptor kinase profiles identify a rationale for multitarget kinase inhibition in immature T-ALL
Authors: L Lhermitte, R Ben Abdelali, P Villarèse, N Bedjaoui, V Guillemot, A Trinquand, M Libura, A S Bedin, A Petit, H Dombret, G Leverger, N Ifrah, O Hermine, E Macintyre, V Asnafi
Journal: Leukemia (2012)
A Text-book of Ophthalmology.
Authors: Harold G. Scheie, Daniel M. Albert, Francis Heed Adler
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Ophthalmology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Ophthalmology journal
Expired carbon dioxide: a noninvasive monitor of cardiopulmonary resuscitation.
Authors: C V Gudipati, M H Weil, J Bisera, H G Deshmukh, E C Rackow
Journal: Circulation (1988)

End-tidal CO2 concentration (ETCO2) may serve as a simple noninvasive measurement of the blood flow generated by precordial compression during cardiopulmonary resuscitation (CPR). In a mechanically ventilated porcine preparation of ventricular fibrillation, onset of fibrillation was associated with a rapid decrease in ETCO2 from 4.0 +/- 0.2% to less than 0.7 +/- 0.2%. With precordial compression, it increased to 1.9 +/- 0.3%. Animals that were successfully defibrillated after 12 min of CPR demonstrated an immediate increase in ETCO2. The ETCO2 increased from 1.9 +/- 0.3% to 4.9 +/- 0.3% over an interval of between 30 and 60 sec. These changes in ETCO2 were closely related to proportionally similar decreases and increases in cardiac output (CO), and a close correlation between ETCO2 and CO was demonstrated (r = .92). A similar highly significant correlation between ETCO2 and CO was also demonstrated during open-chest cardiac massage (r = .95). ETCO2 therefore serves as a noninvasive measure of pulmonary blood flow and therefore CO. In 17 successfully resuscitated animals. ETCO2 during precordial compression averaged 1.7 +/- 0.2%, whereas it was only 0.5 +/- 0.1% in five animals in whom resuscitation procedures were unsuccessful (p less than .001). Accordingly, ETCO2 prognosticates outcome during CPR and immediately identifies restoration of spontaneous circulation.
The Association and Medical Defence
Authors: R. R. Rentoul
Journal: BMJ (1897)

<h3>Objective</h3> To describe the natural history of afferent baroreflex failure (ABF) based on systematic review of clinical and laboratory data in patients with a diagnosis of ABF at Mayo Clinic Rochester. <h3>Methods</h3> We performed a retrospective chart review of all patients who underwent standardized autonomic reflex testing between 2000 and 2020 and had confirmation of the diagnosis of ABF by an autonomic disorders specialist. Patients were identified using a data repository of medical records. Variables included demographic, all-cause mortality, medications, ABF manifestations, comorbidities, and laboratory (autonomic testing, blood pressure monitoring, echocardiogram, brain imaging, plasma catecholamines, serum sodium level, and kidney function tests). <h3>Results</h3> A total of 104 patients with ABF were identified. Head and neck radiation was the most common etiology (86.5%), followed by neck surgery (5.8%) and other causes (7.7%). The most common findings were hypertension (87.5%), fluctuating blood pressure (78.8%), orthostatic hypotension (91.3%), syncope (58.6%), headache (22.1%), and tachycardia (20.2%). Patients commonly received antihypertensives (66.3%), pressor agents (41.3%), or a combination of both (19.2%). The median latency from completion of radiation to ABF was longer compared to the latency in the surgery group (<i>p</i> &lt; 0.0001). Comorbidities, including complications from neck radiation, were frequently seen and all-cause mortality was 39.4% over a 20-year period. <h3>Conclusions</h3> ABF should be suspected in patients with prior head and neck cancer treated by radiation or surgery who present with labile hypertension and orthostatic hypotension. Management may require both antihypertensive and pressor medications. The morbidity and mortality in ABF are high.
Drug Abuse in Viet Nam
Authors: JEROME CHAR
Journal: American Journal of Psychiatry (1972)

The author studied patterns of drug abuse in Viet Nam among three groups of enlisted men—those finishing a 12-month tour, those who had been psychiatric outpatients, and new arrivals. Among those in the first two groups using hard drugs and/or marijuana, a majority used hard drugs. Of the men using drugs in the first two groups, 34 percent began doing so in Viet Nani, while 58 percent of the men using drugs in all three groups began as civilians before entering the military. The implications of these findings are discussed in terms of the military and of society.
Increased prevalence of latex‐sensitization among children with chronic renal failure
Authors: E. Dehlink, C. Prandstetter, T. Eiwegger, B. Putschögl, R. Urbanek, Z. Szépfalusi
Journal: Allergy (2004)

Background: Type‐I‐allergy to natural rubber latex (NRL) has been shown to be more prevalent among certain groups of patients. Children suffering from chronic renal failure (CRF) could be a suspected risk group because of their intense exposure to latex through catheters, gloves and anesthetic equipment during frequent hospitalizations from early life on. We investigated the prevalence of latex‐sensitization among this group of patients and sought to identify risk factors. Methods: Ninety‐three patients (mean age 10.5 years) suffering from CRF were assessed by questionnaire‐based history (details on renal disease, number and kind of surgical procedures, family and personal history of atopic diseases, allergic reactions to NRL, and the use of pacifiers) and by measurement of total and latex‐specific serum immunoglobulin (Ig)E. Results: Ten of 93 (10.8%) patients showed elevated latex‐specific IgE‐levels. One of 10 patients reported clinical symptoms to latex‐allergen, but no allergic reactions to NRL during medical care were reported. Sensitized patients were significantly more likely to be atopic, reflected by a positive history of other allergies as well as elevated total serum IgE‐levels, and had a significantly higher number of urogenital surgeries ( P = 0.02 in all cases, Fisher's exact and Wilcoxon test, respectively). Conclusion: This study demonstrates that children with CRF are at increased risk of latex‐hypersensitivity. Significant associations with atopy and repeated surgeries were observed. Larger studies are required to elucidate whether these children are also at increased risk of anaphylaxis and therefore deserve preventive measures.
REMISSION OF RELAPSED LEUKÆMIA DURING A GRAFT-VERSUS-HOST REACTION A "GRAFT-VERSUS-LEUKÆMIA REACTION" IN MAN?
Authors: LorrieF. Odom, JohnH. Githens, Helvise Morse, Brahma Sharma, CharlesS. August, JamesR. Humbert, David Peakman, StuartL. Rusnak, FranklinB. Johnson
Journal: The Lancet (1978)
The Inotropic Action of Paired Pulse Stimulation in the Normal and Failing Heart: an Experimental Study
Authors: A. J. King, D. E. M. Taylor
Journal: Cardiovascular Research (1968)

Fixed rate single and paired pulse stimulation has been compared in the normal dog left ventricle and in the left ventricle failing after myocardial damage. In the normal heart a persistent positive inotropic effect occurred, seen mainly as an increase in rate of rise of left ventricular pressure, rather than total work. In the failing heart there was a transient positive inotropic effect, followed by increasing ventricular failure. The increasing failure was reversed by a return to single pulse stimulation.