Cutaneous Reactions to Trimethoprim-Sulfamethoxazole in African Patients with the Acquired Immunodeficiency Syndrome
Authors: ROBERT COLEBUNDERS
Journal: Annals of Internal Medicine (1987)

Letters and Corrections1 October 1987Cutaneous Reactions to Trimethoprim-Sulfamethoxazole in African Patients with the Acquired Immunodeficiency SyndromeROBERT COLEBUNDERS, M.D., LEBUGHE IZALEY, M.D., KAPITA BILA, M.D., KUBI KABUMPANGI, M.D., NADINE MELAMEKA, M.D., MICHEL NYST, M.D., HENRY FRANCIS, M.D., JAMES W. CURRAN, M.D., Ph.D., ROBERT RYDER, M.D., PETER PIOT, M.D.ROBERT COLEBUNDERS, M.D.Search for more papers by this author, LEBUGHE IZALEY, M.D.Search for more papers by this author, KAPITA BILA, M.D.Search for more papers by this author, KUBI KABUMPANGI, M.D.Search for more papers by this author, NADINE MELAMEKA, M.D.Search for more papers by this author, MICHEL NYST, M.D.Search for more papers by this author, HENRY FRANCIS, M.D.Search for more papers by this author, JAMES W. CURRAN, M.D., Ph.D.Search for more papers by this author, ROBERT RYDER, M.D.Search for more papers by this author, PETER PIOT, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-107-4-599_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Trimethoprim-sulfamethoxazole has been shown to be effective treatment forPneumocystis cariniipneumonia (1) and probably as prophylaxis of such infection (2). However, its use in the United States is limited by moderate to severe side effects such as rash, fever, neutropenia, thrombocytopenia, and hepatitis (3). Such side effects are most frequent with high-dose intravenous treatment but have also been reported with low-dose oral prophylactic therapy (2). Cutaneous eruptions occur in 50% to 60% of American patients with the acquired immunodeficiency syndrome (AIDS) treated intravenously and generally develop 1 to 9 days (median, 4) after therapy is initiated...References1. SMALL C, HARRIS C, and FRIEDLAND G. The treatment of Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. Arch Intern Med. 1985;145:837-40. CrossrefMedlineGoogle Scholar2. KAPLAN L, ABRAMS D, and WOFSY C. Trimethoprim-sulfamethoxazole prophylaxis against Pneumocystis carinii pneumonia in acquired immune deficiency syndrome (AIDS) [Abstract]. Clin Res. 1986;33:406A. Google Scholar3. GORDIN F, SIMON G, WOFSY C, and MILLS J. Adverse reactions to trimethoprim-sulfamethoxazole in patients with the acquired immunodeficiency syndrome. Ann Intern Med. 1984;100:495-1. LinkGoogle Scholar4. DEHOVITZ J, JOHNSON W, and PAPE J. Cutaneous reactions to trimethoprim-sulfamethoxazole in Haitians. Ann Intern Med. 1985;103:479-80. LinkGoogle Scholar5. ARNDT K and JICK H. Rates of cutaneous reactions to drugs. JAMA. 1976;235:915-23. CrossrefMedlineGoogle Scholar6. HAZEL E, SETHI N, JACQUETTE G, and DOBKIN J. Diminished sulfa-trimethoprim toxicity in blacks treated for Pneumocystis carinii pneumonia. Int. Conf. on AIDS, June 1-5, 1987. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROBERT COLEBUNDERS, M.D.; LEBUGHE IZALEY, M.D.; KAPITA BILA, M.D.; KUBI KABUMPANGI, M.D.; NADINE MELAMEKA, M.D.; MICHEL NYST, M.D.; HENRY FRANCIS, M.D.; JAMES W. CURRAN, M.D., Ph.D.; ROBERT RYDER, M.D.; PETER PIOT, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySafety of sulfadoxine/pyrimethamine for intermittent preventive treatment of malaria in infants: evidence from large-scale operational research in southern TanzaniaEffect of Trimethoprim-Sulfamethoxazole Prophylaxis on Antimicrobial Resistance of Fecal Escherichia coli in HIV-Infected Patients in TanzaniaTolerance and Acceptability of an Efavirenz-Based Regimen in 740 Adults (Predominantly Women) in West AfricaTrimethoprim-sulfamethoxazole prophylaxis in sub-Saharan AfricaPneumocystis carinii pneumonia in patients with AIDS in South AfricaUnerwünschte Arzneimittelreaktionen, Pathogenese, Klinik, TherapieHypersensitivity reactions to high-dose co-trimoxazole in HIV-infected Malaysian and Scottish patientsEarly chemoprophylaxis with trimethoprim-sulphamethoxazole for HIV-1-infected adults in Abidjan, Côte d'Ivoire: a randomised trialMalaria and human immunodeficiency virus infection among male employees of a sugar estate in MalawiAdverse Events from Drug Therapy for Human Immunodeficiency Virus DiseaseToxidermies et infection par le VIHIDENTIFYING SKIN REACTIONS TO DRUGSCutaneous Disease and Drug Reactions in HIV InfectionSyndrome de Lyell au cours du SIDA: 4 casAdverse reactions to co-trimoxazole in HIV infectionSalmonella bacteremia in African patients with human immunodeficiency virus infection 1 October 1987Volume 107, Issue 4Page: 599-600KeywordsAIDSFeversHepatitisNeutropeniaPneumocystis carinii pneumoniaProphylaxisRashes ePublished: 1 December 2008 Issue Published: 1 October 1987 PDF downloadLoading ...