Hereditary Addison's Disease and Multiple Endocrine Adenomatosis in a Kindred
Authors: JAMES C. MERSHON
Journal: Annals of Internal Medicine (1966)

Article1 August 1966Hereditary Addison's Disease and Multiple Endocrine Adenomatosis in a KindredAutoimmune AspectsJAMES C. MERSHON, M.D., JOHN G. DIETRICH, M.D.JAMES C. MERSHON, M.D.Search for more papers by this author, JOHN G. DIETRICH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-2-252 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRecently, multiple endocrine disorders in individuals have been reported with increasing frequency (1-7). This report describes a kindred with adrenal carcinoma and multiple endocrine adenomatosis in the mother and Addison's disease in four of her children. Antibody studies are reported, and evidence is presented that supports the concepts of genetically determined predisposition to autoimmunity and of polyglandular immunity.METHODSThe urinary 17-hydroxy and 17-ketogenic steroid determinations in Case 4 (L. M.) were performed by a modification of the method of Silber and Porter (8). The urinary 17-ketogenic determinations in Case 5 (V. H.) were performed by the Norymberski method (9)....References1. UNDERDAHLWOOLNERBLACK LOLBBM: Multiple endocrine adenomas, report of eight cases in which parathyroids, pituitary and pancreatic islets were involved. J. Clin. Endocr. 13: 20, 1953. CrossrefMedlineGoogle Scholar2. BALLARDFRAMEHARTSOCK HSBRJ: Familial multiple endocrine adenoma-peptic ulcer complex. Medicine (Balt.) 43: 481, 1964. CrossrefMedlineGoogle Scholar3. BEAVENNELSONRENOLDTHORN DWDHAEGW: Diabetes mellitus and Addison's disease; a report on eight patients and a review of 55 cases in the literature. New Eng. J. Med. 261: 443, 1959. 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Lancet 2: 850, 1961. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Peoria, Illinois, and Iowa City, IowaFrom the Departments of Medicine and Pathology, St. Francis Hospital, Peoria, Ill., and the Department of Medicine, University of Iowa, Iowa City, Iowa.Requests for reprints should be addressed to James C. Mershon, M.D., Department of Internal Medicine, University Hospitals, Iowa City, Iowa 52240. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByThe Pluriglandular SyndromesHLA Antigens in Two Siblings with Autoimmune Addison's DiseasePluriglanduläre endokrine RegulationsstörungenMultiple Endocrine Neoplasia, Type I (MEN I)Pluriglanduläre SyndromeThe Pluriglandular SyndromesAddison's disease and diabetes mellitusAN AUTOPSY CASE OF SCHMIDT'S SYNDROMEMultiple endocrine adenomatosisImmunologic aspects of adrenocortical insufficiency 1 August 1966Volume 65, Issue 2Page: 252-258KeywordsAutoimmunityChildrenEndocrine adenomatosisGenetic diseasesHospital medicineImmunityInfantsThyroid Issue Published: 1 August 1966 PDF DownloadLoading ...