tbuckley/cabot-search huggingface dataset:
Role of cytochrome P450-dependent transient receptor potential V4 activation in flow-induced vasodilatation
Authors: Annemarieke E. Loot, Rüdiger Popp, Beate Fisslthaler, Joris Vriens, Bernd Nilius, Ingrid Fleming
Journal: Cardiovascular Research (2008)

Fluid shear stress elicits endothelium-dependent vasodilatation via nitric oxide and prostacyclin-dependent and -independent mechanisms. The latter includes the opening of Ca2+-operated potassium channels by cytochrome P450 (CYP) epoxygenase-derived epoxyeicosatrienoic acids (EETs) leading to endothelial hyperpolarization. We previously reported that EETs activate the transient receptor potential (TRP) V4 channel in vascular endothelial cells and that Ca2+ influx in these cells in response to mechanical stimuli is dependent on the activation of CYP epoxygenases. We therefore hypothesized that the TRPV4 channel is involved in the flow-induced vasodilatation attributed to the endothelium-derived hyperpolarizing factor (EDHF). In the presence of Nω-nitro-l-arginine methyl ester and diclofenac, precontracted mouse carotid arteries displayed a considerable vasodilatation in response to step-wise increases in luminal flow. The EDHF-mediated, flow-induced vasodilatation could be inhibited by the epoxygenase inhibitor MS-PPOH, was abolished after down-regulation of CYP epoxygenases in tissue culture, and could be restored by viral expression of CYP2C9 in the endothelium. The TRPV4-channel inhibitor ruthenium red (RuR) inhibited the EDHF-mediated flow response, but the combination of MS-PPOH and RuR had no further effect. RuR also inhibited the response in CYP2C9-overexpressing vessels. Moreover, TRPV4-deficient mice demonstrated a blunted EDHF-mediated response to increases in luminal flow in comparison to their wild-type littermates, and the addition of MS-PPOH was without effect in these mice (up to 38 ± 3% in TRPV4−/− vs. 57 ± 6% in TRPV4+/+, P < 0.01). In cultured human endothelial cells, exposure to fluid shear stress induced the translocation of the TRPV4 channel from a perinuclear localization to the cell membrane. We conclude that the TRPV4 channel is involved in flow-induced, endothelium-dependent vasodilatation of murine carotid arteries. Moreover, the activation of the TRPV4 channel by flow requires an active CYP epoxygenase and the translocation of the channel to the cell membrane.
Clinical heterogeneity and differential diagnosis of atopic dermatitis
Authors: M. Deleuran, C. Vestergaard
Journal: British Journal of Dermatology (2014)

Atopic dermatitis (AD) is a chronic or chronically relapsing skin disease that usually presents for the first time before the age of 20 years. The disease displays great clinical heterogeneity and may resemble a number of different disorders, making the correct diagnosis of AD a significant challenge for physicians. Based on the Hanifin and Rajka criteria, the authors outline the common symptoms of AD and provide an overview of the differential diagnoses to help distinguish AD from other conditions within the clinic.
Teaching laparoscopic surgery Role of government centres
Authors: C Fowler, G S Clayden
Journal: BMJ (1994)

underlying diseased subcutaneous tissues.2This flap should be replaced when a healthy bed has been obtained, providing improved cover and reduced deformity.This technique was used in one of three patients, with a considerably improved cosmetic result.3The vascularity of the skin of the head and neck facilitates this approach, but it should be considered when necrotising fasciitis occurs at other sites.
Cephalosporium Midline Granuloma.
Authors: D. Eugene Cowen
Journal: Annals of Internal Medicine (1964)

s1 April 1964Cephalosporium Midline Granuloma.D. Eugene Cowen, M.D. (Associate), David E. Dines, M.D., F.A.C.P.D. Eugene Cowen, M.D. (Associate)Search for more papers by this author, David E. Dines, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-4-731_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHerein is an original report of a 22-year-old white male Colorado farmer who developed a cephalosporium fungus infection. The fungus eroded through his hard palate, resulting in destructive changes in maxilla and mandible. Systemic manifestations of fever, weight loss, and hepatosplenomegaly were associated. Failure of response to surgical drainage, extraction of teeth, treatment with iodides and sulfa, necessitated intensive treatment with amphotericin B for 2 months, after which cultures for cephalosporium became negative.Detailed allergic investigation to prevent a recurrence through the media of serial dilution techniques of intracutaneous testing, using endogenous airborne antigens disclosed a high degree of hypersensitivity... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: D. Eugene Cowen, M.D. (Associate); David E. Dines, M.D., F.A.C.P.Affiliations: Denver, Colorado PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAcremonium kiliense peritonitis complicating continuous ambulatory peritoneal dialysis: report of two casesKerionlike lesion of the scalp due to Acremonium kiliense in a noncompromised boyMiscellaneous Uncommon Diseases Attributed to Fungi and ActinomycetesMiscellaneous Uncommon Diseases Attributed to Fungi and Actinomycetes 1 April 1964Volume 60, Issue 4Page: 731-732KeywordsAmphotericinAntigensFeversGranulomasHepatosplenomegalyHypersensitivityWeight loss ePublished: 1 December 2008 Issue Published: 1 April 1964 PDF downloadLoading ...
Diagnostic Assays in Acute Pancreatitis
Authors: SIEGFRIED MERYN
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 January 1986Diagnostic Assays in Acute PancreatitisSIEGFRIED MERYN, M.D., ALEXANDER KISS, M.D., ALFRED GANGL, M.D.SIEGFRIED MERYN, M.D.Search for more papers by this author, ALEXANDER KISS, M.D.Search for more papers by this author, ALFRED GANGL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-104-1-135_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We read with interest the recent article by Steinberg and colleagues (1) and the editorial by Spechler (2) concerning the value of diagnostic assays in acute pancreatitis. We wish to raise several points in this regard.First, the study included 2 patients with hyperlipidemic pancreatitis as well as 127 control patients with abdominal pain, but the authors did not specify how many of the investigated samples showed lipemia. That serum amylase values in patients with lipemia and clinical signs of acute pancreatitis can be within normal limits is a recently appreciated phenomenon, first recognized in 1971 (3)....References1. STEINBERGGOLDSTEINDAVISSHAMMA'AANDERSON WSNJK. Diagnostic assays in acute pancreatitis: a study of sensitivity and specificity. Ann Intern Med. 1985;102:576-80. LinkGoogle Scholar2. SPECHLER S. How much can we know about acute pancreatitis [Editorial]? Ann Intern Med. 1985;102:704-5. LinkGoogle Scholar3. CAMERONCRISLERMARGOLIS JCS. Acute pancreatitis with hyperlipemia. Surgery. 1971;70:53-8. MedlineGoogle Scholar4. SATAKECHUNGUMEYAMA KYK. Serum elastase 1 levels in pancreatic disease. Am J Surg. 1982;144:239-42. CrossrefMedlineGoogle Scholar5. GULLOVENTRUCCIPLATE LML. Serum elastase in pancreatic disease. Dig Dis Sci. 1984;29:951. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Vienna Medical School A-1090 Vienna Austria PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1986Volume 104, Issue 1Page: 135-135KeywordsAbdominal painAcute pancreatitisHyperlipidemiaPancreatitis Issue Published: 1 January 1986 PDF DownloadLoading ...
Newer Antidepressants and Gabapentin for Hot Flashes: An Individual Patient Pooled Analysis
Authors: Charles L. Loprinzi, Jeff Sloan, Vered Stearns, Rebecca Slack, Malini Iyengar, Brent Diekmann, Gretchen Kimmick, James Lovato, Paul Gordon, Kishan Pandya, Thomas Guttuso, Debra Barton, Paul Novotny
Journal: Journal of Clinical Oncology (2009)

Nonhormonal treatment options have been investigated as treatments for hot flashes, a major clinical problem in many women. Starting in 2000, a series of 10 individual double-blind placebo-controlled studies has evaluated newer antidepressants and gabapentin for treating hot flashes. This current project was developed to conduct an individual patient pooled analysis of the data from these published clinical trials.
Abstract 5746: Circulating cytokine levels, Epstein-Barr viremia and risk of AIDS-related non-Hodgkin lymphoma
Authors: Charles S. Rabkin, Eric A. Engels, Ola Landgren, Rob Schuurman, James J. Goedert
Journal: Cancer Research (2010)

Abstract BACKGROUND: Human immunodeficiency virus (HIV) infection may lead to cytokine dysregulation and decontrol of Epstein-Barr virus (EBV) latency as potential mechanisms for acquired immunodeficiency syndrome (AIDS)-related non-Hodgkin lymphoma (NHL). We therefore examined pre-diagnosis blood levels in AIDS-related NHL cases from three prospective cohort studies of HIV infection. METHODS: Plasma or serum were obtained from cases (n=66) 0.1 - 2.0 (median 1.0) years pre-NHL and from up to three HIV-positive lymphoma-free controls (n=186) sampled at comparable times, matched for cohort, age, race, sex and CD4 count at time of diagnosis. Cytokine measurements used Millipore 30-plex Luminex assays with values normalized by log-transformation; coefficients of variation for blinded replicate samples ranged from 10% - 46%. EBV free viremia was detected by real-time polymerase chain reaction (PCR) assays for the BNRF p143 gene; plasma samples originally collected with heparin anticoagulation (n=110) could not be assessed because of PCR inhibition. Statistical analyses were performed by conditional logistic regression for matched sets. RESULTS: Fifty-seven cases had at least one matched control, with mean (median) CD4 counts of 172 (86)/mm3 for cases and 174 (85)/mm3 for controls. Cases had significantly higher cytokine levels for nine of the 30 measured cytokines, with p&amp;lt;.01 for granulocyte-monocyte colony-stimulating factor (GM-CSF) and interleukin (IL)-15, and p&amp;lt;.05 for IL-1a, IL-4, IL-6, IL-8, IL-12 p40, IL-12 p70 and IL-13. Stepwise selection of a multivariable conditional model identified GM-CSF, IL-12p70 and IL-15 as the most predictive markers, with matched odds ratios (95% confidence intervals) of 1.5 (0.9 - 2.4), 1.5 (0.9 - 2.5) and 1.3 (0.9 - 1.9), respectively. EBV PCR-positivity had a matched odds ratio of 1.6 (0.5-5.0), based on serum and acid-citrate-dextrose plasma samples only. CONCLUSIONS: We found elevations of T-helper type-(Th)1, Th2 and pro-inflammatory cytokines and growth factors up to two years before AIDS-NHL; EBV viremia was not significantly predictive but statistical power was limited. Cytokine hyperstimulation of B-cell proliferation may be an important etiologic pathway to AIDS-related NHL. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 5746.
Cetuximab improved overall survival in colorectal cancer patients in whom other treatments had failed
Authors: James Shaw
Journal: Annals of Internal Medicine (2008)

ACP Journal Club20 May 2008Cetuximab improved overall survival in colorectal cancer patients in whom other treatments had failedJames Shaw, MD, MPHJames Shaw, MD, MPHMassey Cancer Center and Virginia Commonwealth University, Richmond, Virginia, USA (J.S.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-148-10-200805200-02008 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationJonker DJ, O’Callaghan CJ, Karapetis CS, et al. Cetuximab for the treatment of colorectal cancer. N Engl J Med. 2007;357:2040-8. https://pubmed.ncbi.nlm.nih.gov/18003960Clinical Impact RatingsOncology: References1 Folprecht G, Lutz MP, Schöffski P, et al.Ann Oncol. 2006;17:450-6. [PMID: 16303861] Google Scholar2 Jennis A, Polikoff J, Mitchell E, et al. J Clin Oncol. 2005;23:264s. Google Scholar3 Eng C, Maurel J, Scheithauer W, et al. J Clin Oncol. 2007;25:164s. Google Scholar4 Taieb J, Puig PL, Bedenne L. Expert Rev Anticancer Ther. 2008;8:183-9. [PMID: 18279058] Google Scholar Author, Article, and Disclosure InformationAffiliations: Massey Cancer Center and Virginia Commonwealth University, Richmond, Virginia, USA (J.S.)This article was published at Annals.org on 6 May 2008. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 20 May 2008Volume 148, Issue 10Page: JC3-8KeywordsAdverse eventsCancer treatmentChemotherapyColorectal cancerPatientsPhase 2 trialsQuality of lifeRenal diseasesSurvival analysisTreatment guidelines ePublished: 20 May 2008 Issue Published: 20 May 2008 Copyright & PermissionsCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Idiopathic thrombocytopenic purpura and graves disease
Authors: Lubomir J. Valenta, Thomas Treadwell, Richard Berry, Alan N. Elias
Journal: American Journal of Hematology (1982)

Abstract A 31‐year‐old black woman was studied who, at the age of 12 years, underwent splenectomy for a bleeding disorder due to idiopathic thrombocytopenic purpura (ITP). More than 20 years after the first signs of her bleeding disorder, the patient developed signs of Graves disease. This condition was treated with 131 I with resulting hypothyroidism. The rare combination of ITP and Graves disease was considered to be a manifestation of two separate autoimmune diseases. For the second time in the literature, HLA typing was performed in a patient with such a disease combination, and it was found to be of the group A23, A28, and B17. This is different from B8, which is most frequently found in both isolated ITP and Graves disease. Possible racial factors may be involved. It is concluded that more cases of such combined disease need to be studied before possible genetic patterns can be established.
Syphilis Surveillance
Authors: Kenneth J. Tomecki
Journal: JAMA (1976)

Of 5,954 adult inpatients consecutively discharged from a university hospital during a three-month period, only 8.4% had serologic tests for syphilis performed during hospitalization. The testing rate was 20.1% on patients admitted to a medical teaching service and 1.4% on a surgical teaching service. In patients tested, a positive rapid plasma reagin test result was obtained in 6.2% and the diagnosis was confirmed by further testing, but effective therapy was not always given. Only 9 of 30 patient records listed syphilis as a diagnosis on discharge. We conclude that serologic testing for syphilis is routinely omitted in the evaluation of hospitalized patients; even when tests are positive, the results are often ignored. (<i>JAMA</i>236:2641-2642, 1976)
Treatment of Hidradenitis Suppurativa
Authors: George A. Knaysi
Journal: JAMA (1968)

<h3>To the Editors:—</h3> The application of sound surgical principles of drainage to the treatment of chronic recurrent hidradenitis suppurativa is to be encouraged, but it is less often successful than might be thought because of the basic pathology of the disease. That is, when the apocrine glands become the site of chronic infection, intertwining, communicating, and deeply penetrating epithelial lined tracts are produced whose unroofing and exposure is difficult and most often incomplete. It is to be emphasized that in the patients we have treated by surgical excision, almost all have already had multiple surgical incisions and drainages of the type suggested by I Gever. The therapy we advocate is not to be applied to the early and previously untreated case of hidradenitis.
L-Tryptophan: A Possible Natural Hypnotic Substance
Authors: Ernest Hartmann
Journal: JAMA (1974)

Millions of persons take something to help them sleep, whether it be one of the traditional hypnotics, a shot of alcohol, a glass of milk, or one of the modern and supposedly proved pharmacological agents. Recently, all-night polygraphic studies enabling the identification of the "infrastructure" of sleep have allowed a more detailed look at what occurs in the brain and body during a night of sleep with and without medication. One disturbing finding has been that whereas most hypnotic medications do indeed produce behavioral "sleep," they almost always distort the normal fine structure or architecture of sleep. This is true, unfortunately, of the benzodiazepines as well as of the barbiturates. Although there are no hard data indicating that these alterations are detrimental, enough anecdotal evidence exists of a "drugged" or "groggy" feeling in the morning after taking sleeping pills to make one suspect that the altered drug-induced sleep may not
Total suppression of neointimal proliferation after implantation of sirolimus-eluting stents: volumetric intravascular ultrasound results from the randomized RAVEL trial
Authors: Alexandre Abizaid, Patrick Serruys, J.Eduardo Sousa, Pim de Feyter, Andrea Abizald, Antonio Colombo, Giulio Guagliumi, William Wijns, Egon Wuelfert, Marie C. Morice
Journal: Journal of the American College of Cardiology (2002)
FLUPHENAZINE IN PRIVATE PSYCHIATRIC PRACTICE
Authors: LAURA E. MORROW
Journal: American Journal of Psychiatry (1961)

Fluphenazine (Prolixin) is a highly effective tranquilizing agent which may be administered with safety to non-hospitalized patients with a variety of psychiatric illnesses. The drug is especially helpful in facilitating psychotherapy. The almost universal relief of gastrointestinal distress in the patients treated with the drug, the absence of skin rash or photosensitivity or of observable hepatotoxicity, and the low incidence of akathisia made the drug especially useful. A very pleasant side effect reported by many patients was a sense of alertness which was beneficial in those who had been on large doses of chlorpromazine. Some were relieved from long-standing migraine headache or severe headache associated with the menses. In several others, severe allergic manifestations such as urticaria disappeared.
Mechanistic biomarkers provide early and sensitive detection of acetaminophen‐induced acute liver injury at first presentation to hospital
Authors: Daniel J. Antoine, James W. Dear, Philip Starkey Lewis, Vivien Platt, Judy Coyle, Moyra Masson, Ruben H. Thanacoody, Alasdair J. Gray, David J. Webb, Jonathan G. Moggs, Nicholas D. Bateman, Christopher E. Goldring, Kevin B. Park
Journal: Hepatology (2013)

Acetaminophen overdose is a common reason for hospital admission and the most frequent cause of hepatotoxicity in the Western world. Early identification would facilitate patient-individualized treatment strategies. We investigated the potential of a panel of novel biomarkers (with enhanced liver expression or linked to the mechanisms of toxicity) to identify patients with acetaminophen-induced acute liver injury (ALI) at first presentation to the hospital when currently used markers are within the normal range. In the first hospital presentation plasma sample from patients (n = 129), we measured microRNA-122 (miR-122; high liver specificity), high mobility group box-1 (HMGB1; marker of necrosis), full-length and caspase-cleaved keratin-18 (K18; markers of necrosis and apoptosis), and glutamate dehydrogenase (GLDH; marker of mitochondrial dysfunction). Receiver operator characteristic curve analysis and positive/negative predictive values were used to compare sensitivity to report liver injury versus alanine transaminase (ALT) and International Normalized Ratio (INR). In all patients, biomarkers at first presentation significantly correlated with peak ALT or INR. In patients presenting with normal ALT or INR, miR-122, HMGB1, and necrosis K18 identified the development of liver injury (n = 15) or not (n = 84) with a high degree of accuracy and significantly outperformed ALT, INR, and plasma acetaminophen concentration for the prediction of subsequent ALI (n = 11) compared with no ALI (n = 52) in patients presenting within 8 hours of overdose.Elevations in plasma miR-122, HMGB1, and necrosis K18 identified subsequent ALI development in patients on admission to the hospital, soon after acetaminophen overdose, and in patients with ALTs in the normal range. The application of such a biomarker panel could improve the speed of clinical decision-making, both in the treatment of ALI and the design/execution of patient-individualized treatment strategies.
The Role of a New Machine
Authors: Bruce B. Dan
Journal: JAMA (1985)

Casual inspection of the several hundred papers that arrive atThe Journaleach month reveals that about a third of them have obviously been produced on a word processor. Interestingly, a larger fraction of manuscripts from university-affiliated researchers are prepared with the help of computer software, bespeaking the availability of word processing equipment at those institutions. Besides the ease of initial preparation of the manuscript, word processing allows authors to respond to editors' and reviewers' requests for revision with just a few strategic keystrokes. Not only has word processing reduced the quantity of typing necessary to prepare a manuscript, but it has also improved the quality of the writing. Many authors state that they are no longer limited to one or two drafts of their work; word processing has given them the opportunity to polish the paper a dozen times over. Despite the fact that medical publications have gone electronic,
Letter: Anemia in the elderly.
Authors: H S Lo, C W Wilson
Journal: BMJ (1973)

be widespread I now accept the majority view that there should be a second person present to give the anaesthetic; but this would bring no gain in safety unless that person fully understood and kept constantly in mind the peculiar danger of anaesthesia in the dental chair.Whether this person needs to be qualified in medicine or dentistry is open to question.I think not and have suggested67 the establishment of an alterna- tive grade.-Iam, etc.,
Ancient Disease in the Midwest
Authors: Phil Gunby
Journal: JAMA (1979)

Medicine and archaeology, two fascinating professions, make almost a natural combination. When remains of our early forebears are unearthed, medical knowledge and diagnostic skills often are the only means of filling in the picture of how these ancient peoples lived and died. Morse is one of those who has applied medical knowledge to try to learn how our ancestors, when disabled, adjusted to their environment, how the disability was (or was not) tolerated by their associates, and whether the community offered any crude medical or surgical aid. Bone changes resulting from trauma in these ancients are compared with those in the extensive Civil War collection of the Armed Forces Institute of Pathology (<i>JAMA</i>240:2407, 1978). Many of the American Indian skeletons and artifacts unearthed by Morse and others are 600 or more years old, and he also cites findings and medical-archaeological studies in other parts of the world. Morse, whose
Posterior element pain in an adolescent schoolgirl
Authors: Mark E Batt, Nina Skattum, Blane K Chong, Jeffrey L Tanji
Journal: British Journal of Sports Medicine (1996)

A case is presented of a transitional lumbosacral vertebra in an adolescent girl, presenting with low back pain. There was no evidence of a pars interarticularis defect. Careful assessment of children or adolescents presenting with low back pain is important since back pain in this age group is usually caused by organic disease.