tbuckley/cabot-search huggingface dataset:
EXAMINATION OF THE EFFICACY OF A CHRONIC DISEASE SELF-MANAGEMENTRAMME (CDSMP) FOR PATIENTS WITH INFLAMMATORY BOWEL DISEASE (IBD): A PILOT STUDY
Authors: M Forry, E McDonnell, J Wilson O'Raghallaigh, O Kelly, A O'Toole, S Patchett
Journal: Gut (2013)

<h3>Introduction</h3> The need for a psychosocial intervention for patients with IBD was recognised by multidisciplinary healthcare professionals working at a large Irish teaching hospital. CDSMP, developed by Stanford University, was identified as a leading model of psychosocial intervention. Run over 6 weeks in 2.5 hour weekly sessions and delivered by two people, one of whom must have a chronic illness, the CDSMP focuses on action planning and goal setting, using brainstorming exercises to help develop self management techniques. <h3>Aims/Background</h3> To pilot the use of a CDSMP in patients with IBD. <h3>Method</h3> A repeated measures design with wait list control (n=44) was utilised. Mood and general health related quality of life (HRQoL) were assessed using the Hospital Anxiety and Depression scale (HADS) and Rand 36-Item Health Survey (SF-36). The Short Inflammatory Bowel Disease Questionnaire (SIBDQ) was used to measure physical, social, and emotional status in patients with IBD. Qualitative descriptions of problems caused by chronic disease were noted the beginning and end of the six week intervention. <h3>Results</h3> 44 patients participated in the pilot study, 11 male (25%) and 33 female (75%). Significant improvement in mood was achieved in treatment group with paired sample t-tests indicated significant reduction in levels of depression on the HADS (p=0.05). At baseline, 14% of the treatment group displayed mild depression. Post-intervention no clinical levels of depression were evident in the treatment group compared to 17% of waitlist control who displayed mild to severe levels of depression. Significant improvement was noted in the SF-36 on the factor of emotional well-being (p=0.04). There was also an improvement in the qualitative descriptions of problems related to chronic disease. Of note, 14% of the treatment group were experiencing relapses in their condition at the end of the CDSMP. <h3>Conclusion</h3> The results of this study indicate that CDSMP appears to be an effective psychosocial intervention for patients with IBD. Implementation of a CDSMP in hospital and community settings in Ireland for this patient group should be considered.
A modification of the Omeract RA MRI score for erosions for use with an extremity MRI system with reduced field of view
Authors: J. E Freeston, E. Olech, D. Yocum, E. M A Hensor, P. Emery, P. G Conaghan
Journal: Annals of the Rheumatic Diseases (2007)

<h3>Objectives:</h3> To develop and test the reliability of a modified version of the OMERACT rheumatoid arthritis magnetic resonance imaging score (RAMRIS) for erosions using extremity MRI (eMRI) with reduced field of view (RAMRIS-RV). <h3>Methods:</h3> Using a MagneVu 0.2 T machine, the preliminary RAMRIS-RV assessed erosions in metacarpophalangeal (MCP) joints 2–3, bases of metacarpal (MC) 2–5, and all wrist bones excluding base MC 1, pisiform and trapezium. T1 weighted images of ⩾500 MCP and wrist bony sites from a mixed severity RA and control cohort were evaluated. An inter-reader reliability study evaluating 300 wrist and 160 MCP bony sites was then performed. <h3>Results:</h3> Mean per cent exact (and close) agreement results were as follows: MCP proximal sites 83.5 (96.2), MCP distal 54.4 (77.2), bases MC 2–4 85.2 (96.7), carpal bones 79.0 (92.1), distal radius/ulna 66.4 (87.8). The base of MCP 5 was visualised in ⩽50% cases (13/25) and was removed from the final RAMRIS-RV. <h3>Conclusions:</h3> The RAMRIS-RV is a practical tool that can be used with eMRI with a reduced field of view. This study shows excellent inter-reader reliability for erosion assessment, albeit in a reduced number of bony sites.
Targeting NEDD8-Activated Cullin-RING Ligases for the Treatment of Cancer
Authors: Teresa A. Soucy, Peter G. Smith, Mark Rolfe
Journal: Clinical Cancer Research (2009)

Abstract E3 ubiquitin ligases regulate many dynamic cellular processes important for cancer cell survival. Together with ubiquitin-activating enzyme (E1) and ubiquitin-conjugating enzymes (E2s), E3s catalyze the ubiquitination of numerous protein substrates that are subsequently targeted to the 26S proteasome for degradation. The clinical success of the proteasome inhibitor bortezomib has encouraged the evaluation of other components of the ubiquitin proteasome system for pharmaceutical intervention. Targeting specific E3s is particularly attractive because there is the potential to selectively block the degradation of certain cellular proteins and possibly avoid unwanted effects on other proteins. The cullin-RING ubiquitin E3 ligases (CRLs) represent the largest subfamily of E3s. The requirement that CRLs be activated by NEDD8 modification on the cullin protein offers an “achilles heel” for modulating this entire subfamily. NEDD8-activating enzyme (NAE) catalyzes the first step in the NEDD8 pathway and as such controls the activity of CRLs. In this article, we describe the role of the NEDD8 pathway in activating CRLs and discuss the preclinical findings with a first-in-class NAE inhibitor that is currently in phase I clinical trials for both solid tumor and hematological malignancies. In addition, we speculate where NAE inhibitors may find clinical utility.
The dendritic cell: its role in intestinal inflammation and relationship with gut bacteria
Authors: A J Stagg
Journal: Gut (2003)

Dendritic cells are antigen presenting cells that are likely to be pivotal in the balance between tolerance and active immunity to commensal microorganisms that is fundamental to inflammatory conditions, including Crohn's disease and ulcerative colitis. Interactions between dendritic cells and microbial products are discussed and how they contribute to regulation of immune responses. The concept that interactions between dendritic cells and commensal organisms may be responsible for maintaining intestinal immune homeostasis is also explored.
IMMUNOCHEMICAL STUDIES ON BLOOD GROUPS
Authors: Harold Baer, Zacharias Dische, Elvin A. Kabat
Journal: The Journal of Experimental Medicine (1948)

It has been possible, by employing a new color reaction for methylpentoses, to determine the fucose content of individual hog and human blood group A, B, and O substances. The data indicate an inverse correlation between fucose content of the hog A and O substances and ability to cross-react with Type XIV antipneumococcus serum. The human A, B, and O substances display no correlation between their fucose content and ability to cross-react with Type XIV antipneumococcus serum.
Cytokine gene expression in murine epidermal cell suspensions: interleukin 1 beta and macrophage inflammatory protein 1 alpha are selectively expressed in Langerhans cells but are differentially regulated in culture.
Authors: C Heufler, G Topar, F Koch, B Trockenbacher, E Kämpgen, N Romani, G Schuler
Journal: The Journal of Experimental Medicine (1992)

Epidermal Langerhans cells (LC) are considered direct yet immature precursors of dendritic cells (DC) in the draining lymph nodes. Although the development of LC into potent immunostimulatory DC occurs in vitro and has been studied in detail, little is known about their profile of cytokine gene expression. By using reverse transcriptase polymerase chain reaction analysis to screen 16 cytokines followed by Northern blotting for selected analysis, we determined the cytokine gene expression profile of murine LC at different time points in culture when T cell stimulatory activity is increasing profoundly. LC regularly expressed macrophage inflammatory proteins, MIP-1 alpha and MIP-2, and interleukin 1 beta (IL-1 beta). Both MIPs were downregulated upon culture and maturation into DC, whereas IL-1 beta was strongly upregulated in culture. MIP-1 alpha and IL-1 beta mRNA were found only in LC, but not in other epidermal cells. Apart from trace amounts of IL-6 in cultured LC, several macrophage and T cell products were not detected. The cytokine expression profile of LC thus appears distinct from typical macrophages. The exact role of the cytokine genes we found transcribed in LC remains to be determined.
FUNCTION-RELATED PLASTICITY IN HYPOTHALAMUS
Authors: Glenn I. Hatton
Journal: Annual Review of Neuroscience (1997)

▪ Abstract Physiological activation of the magnocellular hypothalamo-neurohypophysial system induces a coordinated astrocytic withdrawal from between the magnocellular somata and the parallel-projecting dendrites of the supraoptic nucleus. Neural lobe astrocytes release engulfed axons and retract from their usual positions along the basal lamina. Occurring on a minutes-to-hours time scale, these changes are accompanied by increased direct apposition of both somatic and dendritic membrane, the formation of dendritic bundles, the appearance of novel multiple synapses in both the somatic and dendritic zones, and increased neural occupation of the perivascular basal lamina. Reversal, albeit with varying time courses, is achieved by removing the activating stimuli. Additionally, activation results in interneuronal coupling increases that are capable of being modulated synaptically via second messenger–dependent mechanisms. These changes appear to play important roles in control and coordination of oxytocin and vasopressin release during such conditions as lactation and dehydration.
Health-Related Quality of Life During and After Intraperitoneal Versus Intravenous Chemotherapy for Optimally Debulked Ovarian Cancer: A Gynecologic Oncology Group Study
Authors: Lari B. Wenzel, Helen Q. Huang, Deborah K. Armstrong, Joan L. Walker, David Cella
Journal: Journal of Clinical Oncology (2007)

Purpose A Gynecologic Oncology Group (GOG) randomized phase III trial (GOG 172) in optimal stage III epithelial ovarian cancer showed that intravenous (IV) paclitaxel plus intraperitoneal (IP) cisplatin and paclitaxel significantly lengthened progression-free survival and overall survival compared with IV paclitaxel and cisplatin. The purpose of this report is to comprehensively evaluate the patient-reported outcomes associated with IP versus IV therapy. Patients and Methods Four hundred fifteen eligible women were enrolled onto GOG 172 at member institutions. The Functional Assessment of Cancer Therapy–Trial Outcome Index (FACT-TOI; which includes physical, functional, and ovarian subscales) and neurotoxicity (Ntx) and abdominal discomfort (AD) subscales were used to assess patient-reported outcomes. Assessments were completed before random assignment, before cycle 4, and 3 to 6 weeks and 12 months after treatment. Results Physical and functional well-being and ovarian cancer symptoms were significantly worse in the IP arm before cycle 4 (P &lt; .001) and 3 to 6 weeks after treatment (P = .001 for FACT-TOI). Patients in the IP arm also reported significantly worse AD before cycle 4 (P &lt; .001) and significantly worse Ntx 3 to 6 weeks (P = .001) and 12 months (P = .003) after completing IP treatment. In general, however, the quality of life of both groups improved over time. Conclusion During active treatment, patients on the IP arm experienced more health-related quality-of-life disruption, AD, and Ntx compared with patients receiving conventional IV therapy. However, only Ntx remained significantly greater for IP patients 12 months after treatment. This trade-off should be included when discussing treatment options with patients. Future studies to mitigate the added burden associated with IP therapy are planned.
Outpatient management of childhood asthma by paediatrician or asthma nurse: randomised controlled study with one year follow up
Authors: A W A Kamps, P L P Brand, J L L Kimpen, A R Maillé, A W Overgoor-van de Groes, L C J A M van Helsdingen-Peek, R J Roorda
Journal: Thorax (2003)

<b>Background:</b> Until now, care provided by asthma nurses has been additional to care provided by paediatricians. A study was undertaken to compare nurse led outpatient management of childhood asthma with follow up by a paediatrician. <b>Methods:</b> Seventy four children referred because of insufficient control of persistent asthma were randomly allocated to 1 year follow up by a paediatrician or asthma nurse. The main outcome measure was the percentage of symptom-free days. Additional outcome measures were airway hyperresponsiveness, lung function, daily dose of inhaled corticosteroids (ICS), number of exacerbations, number of additional visits to the general practitioner, absence from school, functional health status, and disease specific quality of life. <b>Results:</b> There were no significant differences at the end of the 1 year study period between the two treatment groups in percentage of symptom-free days (mean difference 2.5%; 95% CI −8.8 to 13.8), airway hyperresponsiveness (log<sub>10</sub> PD<sub>20</sub> 0.06; −0.19 to 0.32), functional health status (10.1; −0.3 to 19.8), disease specific quality of life of patients (0.08; −0.9 to 0.7), and disease specific quality of life of caregivers (0.09; −0.2 to 0.3), nor in any other outcome parameters. Most outcome parameters improved considerably over the 1 year study period. These improvements were achieved although the daily dose of ICS was reduced by a mean of 26% compared with the dose received by children at referral. All parents were satisfied with the asthma care received. <b>Conclusions:</b> After initial assessment in a multidisciplinary clinic, childhood asthma can be successfully managed by an asthma nurse in close cooperation with a paediatrician. During close follow up by paediatrician or asthma nurse, asthma control improved despite a reduction in ICS dose.
Rhinoviruses significantly affect day-to-day respiratory symptoms of children with asthma
Authors: Euan R. Tovey, Sacha Stelzer-Braid, Brett G. Toelle, Brian G. Oliver, Helen K. Reddel, Christiana M. Willenborg, Yvonne Belessis, Frances L. Garden, Adam Jaffe, Roxanne Strachan, Darryl Eyles, William D. Rawlinson, Guy B. Marks
Journal: Journal of Allergy and Clinical Immunology (2014)
Hallucinations and acetylcholine: Signal or noise?
Authors: Anita A. Disney, Simon R. Schultz
Journal: Behavioral and Brain Sciences (2004)

The cholinergic system is a good candidate for the role of determining the relative weight given in cortical information processing to new sensory information versus prior knowledge. We discuss the physiological data supporting this, and suggest that this Bayesian perspective can easily be reconciled with the dynamical framework proposed by Behrendt &amp; Young (B&amp;Y).
An endogastric capsule for measuring tumor markers ingastric juice: an evaluation of the safety and efficacy of a new diagnostic tool
Authors: P. Muretto, F. Graziano, M.P. Staccioli, I. Barbanti, A. Bartolucci, G. Paolini, D. Giordano, E. Testa, A. De Gaetano
Journal: Annals of Oncology (2002)
Vascular endothelial growth factor gene polymorphisms associated with prognosis for patients with gastric cancer
Authors: J.G. Kim, S.K. Sohn, Y.S. Chae, Y.Y. Cho, H-I Bae, G. Yan, J.Y. Park, M-H Lee, H.Y. Chung, W. Yu
Journal: Annals of Oncology (2007)
CYP2D6 and UGT2B7 Genotype and Risk of Recurrence in Tamoxifen-Treated Breast Cancer Patients
Authors: James M. Rae, Suzy Drury, Daniel F. Hayes, Vered Stearns, Jacklyn N. Thibert, Ben P. Haynes, Janine Salter, Ivana Sestak, Jack Cuzick, Mitch Dowsett
Journal: JNCI Journal of the National Cancer Institute (2012)

BackgroundAdjuvant tamoxifen therapy substantially decreases the risk of recurrence and mortality in women with hormone (estrogen and/or progesterone) receptor–positive breast cancer. Previous studies have suggested that metabolic conversion of tamoxifen to endoxifen by cytochrome P450 2D6 (CYP2D6) is required for patient benefit from tamoxifen therapy.
Physical activity during leisure time and quality of life in a Spanish cohort: SUN (Seguimiento Universidad de Navarra) Project
Authors: Almudena Sanchez-Villegas, Ignacio Ara, Trinidad Dierssen, Carmen de la Fuente, Cristina Ruano, Miguel A Martínez-González
Journal: British Journal of Sports Medicine (2011)

Leisure-time physical activity (LTPA) has been associated with better mental and physical health particularly in cross-sectional studies. Purpose To longitudinally assess the association between LTPA, changes in LTPA and health-related quality of life (HRQL).Cross-sectional and prospective analysis of the Seguimiento Universidad de Navarra Project, a dynamic cohort study. Information is gathered through mailed questionnaires biannually since 1999. A validated LTPA questionnaire was used to assess LTPA level at baseline. Changes in LTPA were ascertained at 2 and 4 years of follow-up. HRQL was assessed at 4 and 8 years of follow-up with a validated Spanish version of the SF-36 Health Survey. Multivariate regression coefficients, means and their 95% CIs for each of the eight domains of the SF-36 according to quintiles of baseline LTPA and changes in LTPA over time were calculated using generalised linear models.At 4 years of follow-up, mean scores for upper quintiles of LTPA (second to highest quintile) of physical functioning, general health, vitality, social functioning and mental health were significantly higher than the mean score obtained for participants with the lowest level of LTPA (first quintile). In general, and independent of previous scores in SF-36 survey, the maintenance or the increase in LTPA levels during follow-up was associated with better scores in HRQL after 8 years of follow-up, especially for mental domains.These findings provide support for an association between LTPA, long-term changes in LTPA and several aspects of HRQL (especially in relation to mental domains) extending previous cross-sectional findings.
Sensitivity to change of AIMS2 and AIMS2-SF components in comparison to M-HAQ and VAS-pain
Authors: Erik Taal, Johannes J. Rasker, R.P. Riemsma
Journal: Annals of the Rheumatic Diseases (2004)

<b>Objective:</b> To examine sensitivity to change of Dutch versions of AIMS2 (arthritis impact measurement scales–2) and AIMS2-SF (short form) components, in comparison with M-HAQ (modified health assessment questionnaire) and the 100 mm visual analogue scale for pain (VAS-pain) in patients with rheumatoid arthritis. <b>Methods:</b> 218 patients participated in a study on patient education. Participants completed the Dutch AIMS2, M-HAQ, and VAS-pain at baseline and after one year; 165 completed both assessments. The education programme did not have any effect on health status. Patients were classified according to change over one year in their responses to the AIMS2 question about general health perception: improved health (n = 32), no change (n = 101), and poorer health (n = 32). Changes in scores over one year were tested with paired <i>t</i> tests, and standardised response means were calculated for AIMS2 and AIMS2-SF components, M-HAQ total score, and VAS-pain in the three classifications of change in health perception. <b>Results:</b> AIMS2 and AIMS2-SF physical, symptom, and affect components showed similar sensitivity to change. The physical and symptom components performed better than M-HAQ and VAS-pain. AIMS2 and AIMS2-SF social interaction and role components were not sensitive to changes in general health perception. The role component was only applicable in 63 patients, because the others were unemployed, disabled, or retired. <b>Conclusions:</b> AIMS2-SF is a good alternative to the AIMS2 long form for the assessment of health status in rheumatoid arthritis, and is preferable to M-HAQ and VAS-pain. Use of the AIMS2-SF makes it easier and less costly to collect data and reduces the burden on patients.
Impaired function of CD19<sup>+</sup>CD24<sup>hi</sup>CD38<sup>hi</sup>regulatory B cells in patients with pemphigus
Authors: H.-Q. Zhu, R.-C. Xu, Y.-Y. Chen, H.-J. Yuan, H. Cao, X.-Q. Zhao, J. Zheng, Y. Wang, M. Pan
Journal: British Journal of Dermatology (2014)

Journal Article Impaired function of CD19+CD24hiCD38hi regulatory B cells in patients with pemphigus Get access H.‐Q. Zhu, H.‐Q. Zhu Department of Dermatology Rui Jin Hospital School of Medicine Shanghai Jiao Tong University Shanghai ChinaDepartment of Dermatology Rui Jin Hospital North School of Medicine Shanghai Jiao Tong University Shanghai China Search for other works by this author on: Oxford Academic Google Scholar R.‐C. Xu, R.‐C. Xu Department of Dermatology Rui Jin Hospital School of Medicine Shanghai Jiao Tong University Shanghai China Search for other works by this author on: Oxford Academic Google Scholar Y.‐Y. Chen, Y.‐Y. Chen Department of Dermatology Rui Jin Hospital School of Medicine Shanghai Jiao Tong University Shanghai China Search for other works by this author on: Oxford Academic Google Scholar H.‐J. Yuan, H.‐J. Yuan Department of Dermatology Rui Jin Hospital School of Medicine Shanghai Jiao Tong University Shanghai China Search for other works by this author on: Oxford Academic Google Scholar H. Cao, H. Cao Department of Dermatology Rui Jin Hospital School of Medicine Shanghai Jiao Tong University Shanghai China Search for other works by this author on: Oxford Academic Google Scholar X.‐Q. Zhao, X.‐Q. Zhao Department of Dermatology Rui Jin Hospital School of Medicine Shanghai Jiao Tong University Shanghai China Search for other works by this author on: Oxford Academic Google Scholar J. Zheng, J. Zheng Department of Dermatology Rui Jin Hospital School of Medicine Shanghai Jiao Tong University Shanghai China Search for other works by this author on: Oxford Academic Google Scholar Y. Wang, Y. Wang Shanghai Institute of Immunology Shanghai Jiao Tong University Shanghai China Search for other works by this author on: Oxford Academic Google Scholar M. Pan M. Pan Department of Dermatology Rui Jin Hospital School of Medicine Shanghai Jiao Tong University Shanghai China Correspondence Meng Pan. E‐mail: panmeng@medmail.com.cn Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 172, Issue 1, 1 January 2015, Pages 101–110, https://doi.org/10.1111/bjd.13192 Published: 01 January 2015
The membrane-spanning 4-domains, subfamily A (MS4A) gene cluster contains a common variant associated with Alzheimer's disease
Authors: Carmen Antúnez, Mercè Boada, Antonio González-Pérez, Javier Gayán, Reposo Ramírez-Lorca, Juan Marín, Isabel Hernández, Concha Moreno-Rey, Francisco Jesús Morón, Jesús López-Arrieta, Ana Mauleón, Maitée Rosende-Roca, Fuensanta Noguera-Perea, Agustina Legaz-García, Laura Vivancos-Moreau, Juan Velasco, José Miguel Carrasco, Montserrat Alegret, Martirio Antequera-Torres, Salvadora Manzanares, Alejandro Romo, Irene Blanca, Susana Ruiz, Anna Espinosa, Sandra Castaño, Blanca García, Begoña Martínez-Herrada, Georgina Vinyes, Asunción Lafuente, James T Becker, José Jorge Galán, Manuel Serrano-Ríos, Enrique Vázquez, Lluís Tárraga, María Eugenia Sáez, Oscar L López, Luis Miguel Real, Agustín Ruiz
Journal: Genome Medicine (2011)

In order to identify novel loci associated with Alzheimer's disease (AD), we conducted a genome-wide association study (GWAS) in the Spanish population.We genotyped 1,128 individuals using the Affymetrix Nsp I 250K chip. A sample of 327 sporadic AD patients and 801 controls with unknown cognitive status from the Spanish general population were included in our initial study. To increase the power of the study, we combined our results with those of four other public GWAS datasets by applying identical quality control filters and the same imputation methods, which were then analyzed with a global meta-GWAS. A replication sample with 2,200 sporadic AD patients and 2,301 controls was genotyped to confirm our GWAS findings.Meta-analysis of our data and independent replication datasets allowed us to confirm a novel genome-wide significant association of AD with the membrane-spanning 4-domains subfamily A (MS4A) gene cluster (rs1562990, P = 4.40E-11, odds ratio = 0.88, 95% confidence interval 0.85 to 0.91, n = 10,181 cases and 14,341 controls).Our results underscore the importance of international efforts combining GWAS datasets to isolate genetic loci for complex diseases.