tbuckley/cabot-search huggingface dataset:
Lupus nephritis: current issues
Authors: C P Mavragani
Journal: Annals of the Rheumatic Diseases (2003)

Despite the development of new modalities, cyclophosphamide (CYC) remains the preferred initial treatment for severe proliferative lupus nephritis. Controversies continue about the best route, dosage, and duration of CYC treatment. For recalcitrant disease, new immunosuppressive and immunomodulating agents, immunoablative high dose CYC, nucleoside analogues, apheresis, and the biological response modifiers can be considered.
Development, Validation, and Head-to-Head Comparison of Logistic Regression-Based Nomograms and Artificial Neural Network Models Predicting Prostate Cancer on Initial Extended Biopsy
Authors: Satoru Kawakami, Noboru Numao, Yuhei Okubo, Fumitaka Koga, Shinya Yamamoto, Kazutaka Saito, Yasuhisa Fujii, Junji Yonese, Hitoshi Masuda, Kazunori Kihara, Iwao Fukui
Journal: European Urology (2008)
Book Review Cerebrovascular Disease: Momentum at the End of the Second Millennium (American Heart Association Monograph Series.) Edited by Dennis W. Choi, Ralph G. Dacey, Jr., Chung Y. Hsu, and William J. Powers. 455 pp., illustrated. Armonk, N.Y., Futura, 2001. $125. 0-87993-484-0
Authors: Marc Hommel
Journal: New England Journal of Medicine (2003)
Eye pain with nifedipine and disturbance of taste with captopril: a mutually controlled study showing a method of postmarketing surveillance
Authors: D. M Coulter
Journal: BMJ (1988)

Several notifications of eye pain and blurred vision associated with treatment with nifedipine were received by New Zealand9s Intensive Medicines Monitoring Programme. A questionnaire survey of patients taking nifedipine was undertaken to test the importance of these associations, with disturbance of taste associated with captopril taken as a methodological control. Altogether 961 patients taking nifedipine and 368 taking captopril were sent a questionnaire that asked whether any eye problems and changes in the sense of taste had occurred while they were taking the drug and whether these had resolved after treatment was stopped. Compliance was high: of 922 and 343 questionnaires that were assumed to have been delivered to patients taking nifedipine and captopril, respectively, 770 (84%) and 295 (86%) were returned satisfactorily completed. The distribution of sex was comparable in the two groups; patients taking captopril were slightly younger. Eye symptoms were reported in both groups, but eye pain was significantly more common in patients taking nifedipine (107 (14%) compared with 26 (9%) patients taking captopril). This is a new finding and may be related to ocular vasodilatation. Theoretically, glaucoma is a possible adverse reaction. Loss of taste was significantly associated with captopril, but no other disturbances of taste showed significant associations. Loss of taste persisted in 27 out of 35 patients who continued to take captopril and in three out of eight patients when the drug was withdrawn. This study showed a method of assessing early signs of adverse drug reactions, which has been used once before and identified previously unrecognised reactions.
Prognostic relevance of proliferation and cell adhesion markers inliver transplantation for metastatic neuroendocrine tumors
Authors: J. Rosenau, M.J. Bahr, R.v Wasielewski, M. Mengel, B. Nashan, J. Klempnauer, M.P. Manns, K.H.W. Böker
Journal: Journal of Hepatology (2000)
Tamoxifen Hormonal Effects
Authors: J. D. VELDHUIS
Journal: Annals of Internal Medicine (1979)

Letters and Corrections1 March 1979Tamoxifen Hormonal EffectsJ. D. VELDHUIS, M.D.J. D. VELDHUIS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-3-443_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The report by Patterson and colleagues in the December issue (1) provides access to clinical data on adverse drug effects occasionally reported in association with tamoxifen use, but unfortunately is subject to the well-recognized limitations of ascertainment bias produced by a spectrum of factors (frequency of specific sampling for hypercalcemia, tumor estradiol receptor status, inclination to report or register the adverse effect, and so on). More important, however, their perspective neglects certain fundamental, current concepts in the molecular endocrinology of hormone action. These concepts may clarify some of the ostensibly confusing and seemingly unrelated effects occasionally noted...References1. PATTERSON J, FURR B, and BATTERSBY L: Tamoxifen and hypercalcemia (letter). Ann Intern Med 89:1013, 1978 LinkGoogle Scholar2. PLOTKIN D, LECHNER J, JUNG W, and ROSEN P: Tamoxifen flare in advanced breast cancer. JAMA 240:2644-2646, 1978 CrossrefMedlineGoogle Scholar3. HORWITZ K, KOSEKI Y, and MCGUIRE W: Estrogen control of progesterone receptor in human breast cancer: role of estradiol and antiestrogens. Endocrinology 103:1742-1751, 1978 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: J. D. VELDHUIS, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1979Volume 90, Issue 3Page: 443-443KeywordsDrugsEndocrinologyEstradiolHormonesHypercalcemia ePublished: 1 December 2008 Issue Published: 1 March 1979 PDF downloadLoading ...
Clinical Computed Tomography: Illustrated Procedural Guide
Authors: Joseph H. Privitera
Journal: JAMA (1987)

I doubt there is a physician who, at some time in his or her career, hasn't become the intimate friend of a book whose pages brim with succinct presentations of pragmatic material. In the burgeoning field of computed tomography (CT), there are many volumes that vie with each other in terms of size and weight. None, however, can rival the simplicity of presentation and demonstration of normal anatomy in<i>Clinical Computed Tomography: Illustrated Procedural Guide</i>. The book is short by CT standards, several chapters being no more than four pages long ("Principles and Instrumentation," "Clinical Considerations for the CT Division and Technologist," and "Contrast Media Reactions"). These are meant to be no more than introductory in content, although even in their abbreviated form they yield useful information. The chapter that examines contrast media reactions deals only with manifestations of contrast allergy and the disease processes that may lead to renal
Prophylaxis Against Postoperative Atrial Fibrillation
Authors: Mihai V. Podgoreanu, Joseph P. Mathew
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Metastatic gastrointestinal stromal tumors mimicking gastrointestinal polyposis
Authors: Y. Nakanishi, K. Kanda, R. Akitake, H. Seno, T. Chiba, K. Ono, T. Kayahara, Y. Yamashita
Journal: Endoscopy (2010)

A 70-year-old man was admitted to our hospital because of hematemesis. Esophagogastroduodenoscopy showed more than 10 gastric polypoid lesions ([Fig. 1 a]). The smaller lesions were sessile, clearly demarcated, and had whitish erosions on the surface ([Fig. 1 b]). The larger lesions were sub-pedunculated, and indigo carmine staining revealed a constricted base and elongated gastric pits on the surface ([Fig. 1 c]). These endoscopic appearances suggested an epithelial origin and a diagnosis of hyperplastic polyps. Colonoscopy also demonstrated multiple polypoid lesions, which resembled the lesions in the stomach ([Fig. 1 d]). However, histological examination of the biopsy specimens obtained from the gastric and colonic lesions showed an unexpected pathological finding: there was monotypic proliferation of spindle cells, which were KIT-positive on immunostaining ([Fig. 2]). This staining pattern suggested gastrointestinal stromal tumor (GIST). Computed tomography revealed multiple gastrointestinal masses, and the largest mass in the small intestine seemed to have caused invagination and occlusive ileus ([Fig. 3]). The histological findings of a surgically removed small intestinal tumor were indistinguishable from those of the lesions in the stomach and colon (not shown). Therefore, we made a diagnosis of small-intestinal gastrointestinal stromal tumor (GIST) that had metastasized and formed pedunculated polypoid lesions in the stomach and colon. The patient was given systemic chemotherapy consisting of imatinib mesylate and he survived for 1 year after the diagnosis.
TCT-471 The Impact Of First- versus Second-Generation Drug-Eluting Stents On Immediate- and Intermediate-Term Outcomes In A Complex ST-Segment Elevation Myocardial Infarction Population
Authors: Joshua Loh, Hironori Kitabata, Israel Barbash, Danny Dvir, Salem Badr, Rebecca Torguson, Kenneth Kent, Lowell Satler, William Suddath, Augusto Pichard, Ron Waksman
Journal: Journal of the American College of Cardiology (2012)
Lifestyle Changes May Reverse Development of the Insulin Resistance Syndrome. The Oslo Diet and Exercise Study: a randomized trial
Authors: P A Torjesen, K I Birkeland, S A Anderssen, I Hjermann, I Holme, P Urdal
Journal: Diabetes Care (1997)

OBJECTIVE To compare and assess the single and joint effect of diet and exercise intervention for 1 year on insulin resistance and the development leading toward the insulin resistance syndrome. RESEARCH DESIGN AND METHODS An unmasked, randomized 2 × 2 factorial intervention trial was applied with a duration of 1 year for each participant. The trial comprised 219 men and women with diastolic blood pressure of 86–99 mmHg, HDL cholesterol &amp;lt; 1.20 mmol/l, triglycerides &amp;gt; 1.4 mmol/l, total cholesterol of 5.20–7.74 mmol/l, and BMI &amp;gt; 24 kg/m2. Participants were randomly allocated to diet group (n = 35), diet and exercise group (n = 67), exercise group (n = 54), and control group (n = 43). The diet included increased intake of fish and reduced total fat intake. The exercise program entailed supervised endurance exercise three times a week. Baseline cross-sectional changes and 1-year changes in insulin resistance, fasting serum levels of insulin, C-peptide, proinsulin, glucose, and lipids as well as weight, mean blood pressure, and plasminogen activator inhibitor 1 (PAI-1) values were recorded. RESULTS The cross-sectional results at baseline showed significant correlations between the calculated insulin resistance and BMI (r = 0.54) and correlations between the mean blood pressure (mBP) (r = 0.26) and PAI-1 (r = 0.40). The 1-year diet intervention gave a significant decrease in the calculated insulin resistance from 4.6 to 4.2 and a positive correlation between the changes in insulin resistance and changes in BMI (r = 0.40). The diet and exercise intervention also led to significantly decreased insulin resistance (from 5.0 to 4.0). The exercise intervention did not significantly change insulin resistance. CONCLUSIONS The cross-sectional and 1-year intervention results supported each other and underscored the important connection between increased BMI and the development leading toward the insulin resistance syndrome.
Complications of Diagnostic Paracentesis in Patients With Liver Disease
Authors: Andrew Mallory
Journal: JAMA (1978)

A retrospective analysis of 242 consecutive diagnostic abdominal paracenteses in patients with liver disease disclosed seven major complications, including serious hemorrhage (four), perforation of bowel with generalized peritonitis (one), perforation of bowel with abdominal wall abscess (one), and a catheter fragment left in the abdominal wall or cavity (one). The results of this study emphasize the potential dangers of this procedure in these patients and raise the possibility that complications may be more common than previously thought. (<i>JAMA</i>239:628-630, 1978)
Neurosurgery: Ancient, Modern, or Both?
Authors: Robert L. Martensen
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract P5-13-07: Genetic polymorphism of estrogen metabolizing enzyme CYP17A1 rs743572 impacts on serum testosterone level in Japanese premenopausal women
Authors: N Yoshimoto, T Nishiyama, H Yamashita, S Takahashi, N Shiraki, H Sugiura, Y Endo, M Iwasa, T Asano, Y Hato, Y Fujii, T Toyama
Journal: Cancer Research (2013)

Abstract The incidence of breast cancer in Japanese women has doubled in all age groups over the past two decades. We recently demonstrated that this marked increase is mostly due to an increase in the estrogen receptor (ER)-positive subtype, and we created risk prediction models for ER-positive breast cancer in both pre- and post- menopausal women using genetic factors (single nucleotide polymorphism (SNP)), environmental risk factors, serum hormones and growth factors by logistic regression analysis. Serum level of testosterone, which is the precursor of estradiol in estradiol synthesis, was found to be a risk predictor in both pre- and post- menopausal women. On the other hand, it has been reported that some SNPs, including those of estrogen-related genes such as ESR1 and CYP17A1, are correlated with breast cancer risk by genome-wide association studies. To acquire some insights into this mechanism, we analyzed genetic factors (14 SNPs), serum hormones and growth factors (estradiol, testosterone, prolactin, insulin-like growth factor 1 (IGF1) and IGF binding protein 3 (IGFBP3)) in 913 women with breast cancer and 278 disease-free controls for correlation between them. Serum testosterone and prolactin levels were significantly higher in ER-positive breast cancer patients than in disease-free controls in both pre- (p&amp;lt;0.0001, p&amp;lt;0.0001) and post- (p&amp;lt;0.0001, p = 0.007) menopausal women, and serum estradiol level was significantly higher in ER-positive breast cancer patients than in disease-free controls only in premenopausal women (p = 0.0005). There were significant differences in serum hormone levels among the women with each SNP genotype (homozygotes of major allele, heterozygotes and homozygotes of minor allele), including testosterone among rs743572 genotype (p = 0.014), estradiol among rs827421 genotype (p = 0.016), IGF-1 among rs6905370 genotype (p = 0.032), and prolactin among rs1042522 genotype (p = 0.035) in premenopausal women, as well as estradiol among rs3803662 genotype (p = 0.027) and IGFBP3 among rs6905370 genotype (p = 0.036) in postmenopausal women. In particular, serum testosterone level was significantly different among the rs743572, which is one of the enzymes that convert testosterone to estradiol, of genotypes (AA: 0.308 +/- 0.180 ng/ml, AG: 0.319 +/- 0.193 ng/ml and GG: 0.380 +/- 0.187 ng/ml, p = 0.014). On the other hand, the rs743572 heterozygotes of CYP17A1 have been reported to have increased breast cancer risk than homozygotes of both the major allele and minor allele in premenopausal women. Further studies are required to clarify this mechanism. Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P5-13-07.
Abstract 1826: Obesity as a therapeutic target for preventing recurrence and mortality in prostate cancer survivors: A meta-analysis of 29 cohort studies
Authors: Yong Sang Song, Hee Seung Kim, Mi-Kyung Kim, Sangchul Lee, Seung Pyo Gong, Yong Beom Kim, Eunsik Lee
Journal: Cancer Research (2011)

Abstract Objective: The role of body mass index (BMI) remains unclear for disease recurrence and survival in patients with prostate cancer. To evaluated the role of BMI in prostate cancer survivors, we performed a meta-analysis for comparing biochemical recurrence-free survival (BCRFS), progression-free survival (PFS) and overall survival (OS) among normal weight (BMI &amp;lt;25 kg/m2), overweight (BMI 25 – 29.9 kg/m2) and obesity (BMI ≥30 kg/m2). Methods: After the extensive literature search till July 2010, we analyzed 29 relevant cohort studies where the role of BMI was investigated for BCRFS, PFS and OS in prostate cancer survivors. We used the fixed-effect model for the meta-analysis because of no observed heterogeneity among all relevant studies (Higgins I2 ≤50%). Results: Although there was no difference in BCRFS between BMI &amp;lt;25 kg/m2 and ≥25 kg/m2 (HR, 1.02, 95% CI, 0.98 to 1.09), BMI ≥30 kg/m2 showed poor BCRFS when compared with BMI &amp;lt;30 kg/m2 (HR, 1.56, 95% CI, 1.48 to 1.65). In sub-analyses for BCRFS, BMI 25 – 29.9 kg/m2 showed poor BCRFS, compared with BMI &amp;lt;25 kg/m2 (HR, 1.08; 95% CI, 1.03 to 1.14), and BMI ≥30 kg/m2 was also associated with poor BCRFS, compared with BMI 25 – 29.9 kg/m2 (HR, 1.20; 95% CI, 1.12 to 1.29). Furthermore, BMI ≥30 kg/m2 was related with PFS (HR, 1.65; 95% CI, 1.43 to 1.91) and OS (HR, 1.73; 95% CI, 1.63 to 1.97) when compared with BMI &amp;lt;30 kg/m2, whereas there were no differences in them between BMI &amp;lt;25 kg/m2 and ≥25 kg/m2 (PFS and OS; HR, 1.01 and 1.05; 95% CI, 0.85 to 1.20 and 0.88 to 1.26). In sub-analyses for PFS and OS, BMI ≥30 kg/m2 also decreased PFS (HR, 1.45; 95% CI, 1.23 to 1.71) and OS (HR, 1.49; 95% CI, 1.29 to 1.72) when compared with BMI 25 – 29.9 kg/m2 in spite of no differences in them between BMI &amp;lt;25 kg/m2 and BMI 25 – 29.9 kg/m2 (PFS and OS; HR, 1.05 and 0.99; 95% CI, 0.88 to 1.26 and 0.88 to 1.11). Finally, these meta-analytic results showed no publication bias among all relevant studies. Conclusion: These findings suggest that overweight (BMI 25 – 29.9 kg/m2) and obesity (BMI ≥30 kg/m2) may be associated with early biochemical recurrence, whereas obesity (BMI ≥30 kg/m2) may influence on clinical poor prognosis such as PFS and OS in prostate cancer survivors. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1826. doi:10.1158/1538-7445.AM2011-1826
ELIGIBILITY FOR POLYPILL THERAPY, SUBCLINICAL ATHEROSCLEROSIS, AND CARDIOVASCULAR EVENTS – NATIONAL IMPLICATIONS FOR THE APPROPRIATE USE OF PREVENTIVE PHARMACOTHERAPY: MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS (MESA)
Authors: Marcio Sommer Bittencourt, Michael Blaha, Ron Blankstein, Jose Vargas, Matthew Budoff, Arthur Agatston, Roger Blumenthal, Khurram Nasir
Journal: Journal of the American College of Cardiology (2013)
THE ULTRASTRUCTURE OF THE SKIN OF HUMAN EMBRYOS V. THE HAIR GERM AND PERIFOLLICULAR MESENCHYMAL CELLS.
Authors: KEN HASHIMOTO
Journal: British Journal of Dermatology (1970)

SUMMARY.— Electron microscopic studies on embryonic hair development were performed using the scalp and eyebrow skin of 10 Negro embryos of the menstrual ages of 9 to 15 weeks. New ultramicroscopic findings were: (1) The peripheral cells of the hair germ extended into the mesenchyme pseudopodia, not covered by the basal lamina. (2) Mesenchymal cells crowded beneath the hair germ were connected with desmosome‐like junctions. Direct contact of these cells with the basal lamina of the hair germ was seen. (3) A halfdesmosome‐ like structure was found between the mesenchymal cells and mesenchymal fine filaments.
Letter: Unexplained hepatitis following halothane.
Authors: W K Slack
Journal: BMJ (1976)

Aortic stenosis (AS) is a common valve disorder in an ageing population in western countries, and women, with longer life expectancy, comprise a substantial percentage of elderly patients with AS. Compared with men, women exhibit distinctive characteristics at the level of stenotic valve leaflets and subsequent compensatory responses of the left ventricle to chronic pressure overload, and in clinical presentation, consequences and response to intervention. Randomised controlled trials of transcatheter aortic valve implantation have yielded new evidence of sex differences in both short-term and long-term outcomes after intervention. A comprehensive knowledge of the existing evidence may inform our understanding of gender differences during assessment and treatment of patients with AS. In this paper, we review the available evidence regarding sex differences in AS in terms of symptoms, clinical presentation, anatomical differences and pathophysiological progression, management and outcomes after aortic valve replacement. Implications for further research are suggested.
Mutations in a new member of the chromodomain gene family cause CHARGE syndrome
Authors: Lisenka E L M Vissers, Conny M A van Ravenswaaij, Ronald Admiraal, Jane A Hurst, Bert B A de Vries, Irene M Janssen, Walter A van der Vliet, Erik H L P G Huys, Pieter J de Jong, Ben C J Hamel, Eric F P M Schoenmakers, Han G Brunner, Joris A Veltman, Ad Geurts van Kessel
Journal: Nature Genetics (2004)
OBSERVATIONS OF A TUBERCULOSIS EXAMINER IN THE ARMY
Authors: CLARENCE L. WHEATON
Journal: JAMA (1918)

The tuberculosis examining board effected an organization in this cantonment during the latter part of November, 1917, and has since been engaged in the examination for pulmonary tuberculosis of all drafted men reporting to this camp. The work of a tuberculosis examining board is in no way connected with the activities of the base hospital. It is essentially a camp board making a field survey for tuberculosis so far as it concerns the men assigned to the depot brigade or the several organizations within the division. The work of a tuberculosis examining board, omitting the details incident to a tuberculosis survey, may be compared with that of a medical officer holding a sick call when it is necessary to examine hurriedly a large number of men, collecting those that need hospital attention.. Prior to the present method of discharging all drafted men on Form 1010 who are physically incapacitated for