The Effect of Experimentally Induced Acute Tularemia in Humans on Nitrogen, Mineral, and Electrolyte Metabolism and on Adrenocortical Function.
Authors: William R. Beisel
Journal: Annals of Internal Medicine (1964)

s1 April 1964The Effect of Experimentally Induced Acute Tularemia in Humans on Nitrogen, Mineral, and Electrolyte Metabolism and on Adrenocortical Function.William R. Beisel, Irving Gray, William D. Sawyer, Dan Crozier, Joseph Bruton, M.S.William R. BeiselSearch for more papers by this author, Irving GraySearch for more papers by this author, William D. SawyerSearch for more papers by this author, Dan CrozierSearch for more papers by this author, Joseph Bruton, M.S.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-4-716_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo assess the interaction of nitrogen, mineral, and electrolyte metabolism and adrenocortical function during infection, volunteer subjects were exposed to aerosolized Pasteurella tularensis while undergoing complete metabolic balance study. Nitrogen, sodium, potassium, phosphate, calcium, and magnesium balances were determined in 16 subjects; in these and 26 others, urinary adrenocortical steroids were also measured.With the onset of acute illness, 17-hydroxycorticosteroid and 17-ketosteroid excretion rose significantly; excretion returned abruptly to normal after institution of therapy. Urinary pregnanetriol increased transiently at the onset of fever. Individuals exposed to attenuated organisms, previously vaccinated or sham exposed showed no appreciable change in steroid excretion... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: William R. Beisel; Irving Gray; William D. Sawyer; Dan Crozier; Joseph Bruton, M.S.Affiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySilicon Carbide, SiCEFFECTS OF CIMETIDINE ON PITUITARY FUNCTION: ALTERATIONS IN HORMONE SECRETION PROFILESMineralocorticoids and the Regulation of Sodium Metabolism in Normal and Hypertensive Pregnancy: A ReviewPituitary-adrenal and pituitary-thyroid function during administration of difluocortolone and dexamethasone to human subjectsDie Stoffwechselwirkungen der SchilddrüsenhormoneSerum AlbuminAdrenal Cortical Response to Neurosurgical Problems, Noting the Effects of Exogenous SteroidsInfluence of indomethacin on the distribution of cortisol in manCompetition between Drugs and Normal Substrates for Plasma and Tissue Binding SitesDrug-Macromolecular Interactions: Implications for Pharmacological ActivityPlasma binding of betamethasone3H, dexamethasone-3H, and cortisol-14C— A comparative studyDiagnostische Bedeutung der Proteinbindung von Plasmacortisol, bestimmt durch DextrangelfiltrationThe Binding of Drugs by Plasma ProteinsThe influence of cortisol and adrenocorticotropic hormone on the sedimentation rate of the red blood cellsKlinische Bedeutung der Trennung von proteingebundenem und sog. freiem Anteil des Plasmacortisols mit Hilfe der DextrangelfiltrationFluorimetrische Bestimmung der sog. 11-Hydroxycorticosteroide im Plasma bei Hyperthyreose und bei NebennierenrindeninsuffizienzBinding of cortisol and its degradation products by human serum albumin 1 April 1964Volume 60, Issue 4Page: 716-717KeywordsCalciumExcretionFeversMagnesiumPhosphatesPotassiumSodiumSteroidsTularemia ePublished: 1 December 2008 Issue Published: 1 April 1964 PDF downloadLoading ...