tbuckley/cabot-search huggingface dataset:
District cancer physicians
Authors: Y. Terry
Journal: BMJ (1987)

Convulsions stopped (they had lasted for no more than 10 minutes), and subsequent blood glucose measurements were satisfactory.Shewas nauseated and complained of headache but had no neck stiffness, photophobia, or focal neurological signs.In a blood sample taken at 740 am the same morning the white cell count was 26 2 x 10/1, 91% neutrophils.A medical senior registrar ordered blood cultures and a viral antibody screen to be performed.At 11 00 am her white cell count was 21 4x 109/1.Further investigations ordered in- cluded culture of nose, throat, rectal, and high vaginal swabs and a catheter specimen of urine.The following morning her white cell count was 12-8 x 109/l.At no stage did she have fever or any symptoms not attributable to hypoglycaemia.All bacteriological and viral investigations yielded negative results.The patient remained well and at 38 weeks delivered a normal, healthy infant.Given the combination of circumstances (late pregnancy, hypoglycaemia with concomitant adrenaline release, and a grand mal convulsion), the pronounced leucocytosis and its time course might reasonably have been predicted and the investigations, which were by no means trivial, either to the patient or to the laboratories, avoided.
Hyperlipidaemia advances and retreats.
Authors: C R Klimt
Journal: BMJ (1980)

this might not be the whole story: "The answer may well be more complicated."A very recent review' of the epidemiology of heart disease supports both comments.In the course of the review I analyse the sex and age pattems of mortality from "ischaemic heart disease" (8th ICD 410-414) in five populations: England and Wales, Scotland, US whites, US non-whites, and Japan.Defined in this way, ischaemic heart disease is heterogeneous, comprising three main components.Most deaths over the age range 30-75 years can, however, be attributed to one component, "acute myocardial infarction" (8th ICD 410).I deduce that genetic factors play two distinctive roles where acute myocardial infarction is concemed.
Viral Infections Contracted in the Laboratory
Authors: S. Edward Sulkin, Robert M. Pike
Journal: New England Journal of Medicine (1949)

THE increased interest in viral diseases in recent years, particularly in the field of laboratory diagnosis, has stimulated more and more laboratories to undertake work with these agents. Diagnostic procedures that formerly were to be found only in periodicals have now been collected in a single volume by Francis and others,1 who present them in a manner for ready reference for the average worker in the diagnostic laboratory. The availability of antigens§ for use in the complement-fixation test makes it possible for any laboratory familiar with this technic to detect an increased antibody titer for a number of viral agents. . . .
Patients are less satisfied with robot assisted prostatectomy, survey shows
Authors: D. Spurgeon
Journal: BMJ (2008)

Men who opt for robot assisted laparascopic radical prostatectomy are around four times as likely to be dissatisfied with their decision as men who choose open retropubic surgery, new research indicates.

The study, which assessed the emotional effects on patients of the two approaches to prostatectomy, involved cross sectional surveys of 400 patients (with a 61% response rate) who underwent radical prostatectomy between 2000 and 2007 ( European Eurology doi:10.1016/j.eururo.2008.06.063).

The …
Clinical Usefulness of Technetium-99m HM-PAO Labeled White Blood Cell Imaging in Abscesses
Authors: L MORTELMANS, A VERBRUGGEN, J AUGUSTINUS, G WILMS, M De ROO
Journal: Clinical Nuclear Medicine (1989)

The widespread use of indium-111 labeled white blood cells is limited by several factors, including the relatively high radiation dose required, the unfavorable cost-benefit ratio, and the time-consuming cell separation procedure. The major drawback, however, is that this tracer is not routinely available in most laboratories. In the case of a patient suffering from a fever of unknown origin, the clinician wants an accurate diagnosis of the problem as soon as possible, preferably within 24 hours. In practice, the indium tracer can rarely be delivered within this time interval. However, labeling of WBCs with Tc-99m-d, 1-HM-PAO is possible within 24 hours. This advantage is illustrated in this article by two case reports.
A Century After Chagas Disease Discovery, Hurdles to Tackling the Infection Remain
Authors: Rebecca Voelker
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
GRENZ RAY TREATMENT OF RECURRENT HERPES SIMPLEX
Authors: A. G. KNIGHT
Journal: British Journal of Dermatology (1972)

Journal Article GRENZ RAY TREATMENT OF RECURRENT HERPES SIMPLEX Get access A. G. KNIGHT A. G. KNIGHT Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 86, Issue 2, 1 February 1972, Pages 172–174, https://doi.org/10.1111/j.1365-2133.1972.tb16082.x Published: 01 February 1972
Comparison of two measures of waiting times
Authors: J. Nicholl
Journal: BMJ (1988)

Careful inspection of the mean values published in the paper show that it is feasible to take a series of garments from within a range and find that they perform in a satisfactory manner-that is, they provide linear graduation and are effective in terms of the particular aspect of venous function which we studied.Our critics, however, have failed to grasp the importance of the work if they do not appreciate that it is important that these criteria should extend throughout the range of garments and be applicable to any of the size ranges supplied by the manufacturer.Further study ofthe materials they quote2 shows that it was necessary for a range of stockings to be manufactured specifically for this study so that graduated compression could be achieved across the patient group.We agree that further work is required, and want to make clear that our study was carried out independently of any manufacturer support; it was undertaken in the interest of applied physiology and the desire to improve the quality of care available to this often neglected group of patients based on objective data that are applicable to the individual subject.
The ion sensitive field effect transistor (ISFET) pH electrode: a new sensor for long term ambulatory pH monitoring.
Authors: P Duroux, C Emde, P Bauerfeind, C Francis, A Grisel, L Thybaud, D Arstrong, C Depeursinge, A L Blum
Journal: Gut (1991)

Intraluminal pH monitoring in man should be performed with disposable multichannel assemblies that allow recordings at multiple sites and prevent transmission of infection. Currently available glass electrodes are unsuitable for this purpose because of their size and price. We have thus constructed and tested a small, combined ion sensitive field effect transistor (ISFET) pH electrode incorporating an integral reference electrode. In vitro studies showed that both ISFET and glass electrodes (440-M4, Ingold, Switzerland) have a linear response over the pH range 1.3-8.0 and that they are comparable with regard to response time and 24 hour drift. Twenty one hour intragastric pH recordings were performed simultaneously in eight healthy volunteers using a glass electrode and an ISFET electrode, placed no more than 2 mm apart in a combined assembly. This was located in the gastric corpus under fluoroscopic control. The 21 hour pH curves recorded by each electrode type showed identical patterns: an early morning rise in pH with three meal-associated pH peaks lasting for about two to three hours. The means of the 21 hour pH medians were 2.09 and 2.07 as measured by the glass and the ISFET electrodes respectively. Thus, ISFETs are suitable for the construction of inexpensive and hence disposable multichannel pH monitoring assemblies of small diameter. Provided that they can be produced in large numbers with appropriate technical support, ISFETs have the potential to replace glass electrodes for long term monitoring of gastrointestinal luminal acidity.
Plasma Cell Dyscrasias
Authors: Bart Barlogie
Journal: JAMA (1992)

PLASMA cell dyscrasias refer to a spectrum of disorders characterized by the monoclonal proliferation of lymphoplasmacytic cells in the bone marrow and, sometimes, tissue deposition of monoclonal immunoglobulins or their components (Table 21-1). The disorders include multiple myeloma (MM) and Waldenström's macroglobulinemia, as well as rare conditions such as light-chain deposition disease (LCDD) and heavy-chain diseases (HCDs). Amyloidosis refers to a group of tissue deposition disorders, among which light-chain amyloidosis is a plasma cell dyscrasia. Monoclonal gammopathy of undetermined significance is an asymptomatic laboratory deviation that may evolve into one of the previously mentioned diseases. <h3>MULTIPLE MYELOMA</h3> Multiple myeloma is the most serious and prevalent plasma cell dyscrasia, affecting approximately four of 100 000 Americans each year (Table 21-2). The median age at onset is 60 years, and black persons are affected twice as often as white persons. Symptoms usually result from lytic bone disease, anemia, renal failure, and immunodeficiency.
Influenza Vaccine Makers Seek Ways to Speed Production, Boost Effectiveness
Authors: Bridget M. Kuehn
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Localized Pulmonary Edema After Blunt Chest Trauma
Authors: Shougo Murakami, Michihiro Suwa, Hideaki Morita, Tomoe Murakami, Takahide Ito, Akiko Soyama, Tatsuji Kono, Yasushi Kitaura, Takahiro Katsumata
Journal: Circulation (2007)
The DURAbility of Basal versus Lispro mix 75/25 insulin Efficacy (DURABLE) Trial
Authors: John B. Buse, Bruce H.R. Wolffenbuttel, William H. Herman, Stephen Hippler, Sherry A. Martin, Honghua H. Jiang, Sylvia K. Shenouda, Jessie L. Fahrbach
Journal: Diabetes Care (2011)

OBJECTIVE This study compared the durability of glycemic control of twice-daily insulin lispro mix 75/25 (LM75/25: 75% insulin lispro protamine suspension/25% lispro) and once-daily insulin glargine, added to oral antihyperglycemic drugs in type 2 diabetes patients. RESEARCH DESIGN AND METHODS During the initiation phase, patients were randomized to LM75/25 or glargine. After 6 months, patients with A1C ≤7.0% advanced to the maintenance phase for ≤24 months. The primary objective was the between-group comparison of duration of maintaining the A1C goal. RESULTS Of 900 patients receiving LM75/25 and 918 patients receiving glargine who completed initiation, 473 and 419, respectively, had A1C ≤7.0% and continued into maintenance. Baseline characteristics except age were similar in this group. Median time of maintaining the A1C goal was 16.8 months for LM75/25 (95% CI 14.0–19.7) and 14.4 months for glargine (95% CI 13.4–16.8; P = 0.040). A1C goal was maintained in 202 LM75/25-treated patients (43%) and in 147 glargine-treated patients (35%; P = 0.006). No differences were observed in overall, nocturnal, or severe hypoglycemia. LM75/25 patients had higher total daily insulin dose (0.45 ± 0.21 vs. 0.37 ± 0.21 units/kg/day) and more weight gain (5.4 ± 5.8 vs. 3.7 ± 5.6 kg) from baseline. Patients taking LM75/25 and glargine with lower baseline A1C levels were more likely to maintain the A1C goal (P = 0.043 and P &amp;lt; 0.001, respectively). CONCLUSIONS A modestly longer durability of glycemic control was achieved with LM75/25 compared with glargine. Patients with lower baseline A1C levels were more likely to maintain the goal, supporting the concept of earlier insulin initiation.
A 50-Year-Old Man With Chronic Low Back Pain
Authors: James P. Rathmell
Journal: JAMA (2008)

Mr S, a 50-year-old man, has long-standing low back pain. His pain began more than 20 years earlier with a lumbar disk herniation and has persisted despite diskectomy. He has undergone numerous treatments, but he remains disabled with ongoing pain. His treatment course is used to frame the epidemiology and pathophysiology underlying acute and chronic lumbosacral and radicular pain. The roles of neuropathic pain medications, chronic opioid therapy, physical therapy, spinal manipulation, and multidisciplinary pain treatment programs are reviewed. The indications for and outcomes associated with interventional pain treatments, including epidural steroid injection, facet blocks and radiofrequency treatment for facet-related pain, intradiskal electrothermal therapy, spinal cord stimulation, and intrathecal drug delivery, are discussed. Clinicians are given an evidence-based approach to using available treatment options for low back pain.
Personal Surgical Errors.
Authors: John A. Wyeth
Journal: JAMA (1907)

New York City, Aug. 8, 1907. <h3>To the Editor:</h3> —It is doubly gratifying to read such an article as that with the above title inThe Journal, July 20. The world is full of honest men, but not so full of brave men, for it takes such a man to own and proclaim his mistakes publicly. Among these errors is one to which I desire to call particular attention; namely, the employment of the catgut purse-string suture in dealing with the stump of the amputated appendix. The patient died suddenly on the third day. The postmortem showed that the suture had given away, and that the bowel contents had escaped into the peritoneal cavity, causing the patient's death. The author continues: "I then commenced to use linen thread; many of these patients, however, complained so bitterly of pain in the region of the stump for several months that I later
Effect of Combined Sympathetic and Vagal Stimulation on Heart Rate in the Dog
Authors: H. R. WARNER, R. O. RUSSELL
Journal: Circulation Research (1969)

A set of equations is described which permit prediction of the time course of heart rate in a dog anesthetized with pentobarbital from the time course of frequency of stimuli applied to the distal cut ends of vagus and sympathetic efferent nerves to the heart.These equations, although based on assumptions as to the physiological mechanisms involved, were only tested for their ability to describe the kinetic relationship involved.The time course of heart rate resulting from combined vagus and sympathetic nerve stimulation (HR SV ) is given by the equation:HR ST = HR V + (HR S -HR O ) (HR T -HR m i n )/(HR 0 -HR mill ), where the subscripted terms are heart rate values due to vagus stimulation (v), sympathetic stimulation (s), no stimulation (0) and the minimum (min) heart rate achievable by vagus stimulation alone.Clearly the vagus influence is capable of dominating the sympathetic in the control of heart rate. ADDITIONAL KEY WORDS computer nervous control heart rate cardiovascular control• The time course of heart rate resulting from stimulation of the sympathetic or of the vagus nerves to the heart is described by a mathematical model developed by Warner and Cox (1) in 1962.This model predicts the heart rate response to stimulation of either set of nerves alone but will not predict the response to simultaneous stimulation of sympathetic and vagus nerves.It is the purpose of this paper to describe an addition to the model which predicts the response to combined stimulation (2) and to describe experiments designed to test the performance of the model under a variety of stimulus parameters.
Most of UK is now out of step with rest of Europe on drink driving limits
Authors: B. Christie
Journal: BMJ (2014)

Pressure is increasing for lower drink driving limits across the United Kingdom, as Scotland fell into line with most of Europe in reducing its legal limit.

The new law in Scotland, which came into force on 5 December, reduces the amount of blood alcohol that people can legally have before driving from 80 mg to 50 mg in every 100 mL of blood.

Scotland’s justice …
Points: The undiscovered country
Authors: L H Worth
Journal: BMJ (1980)

entitled to private practice, . . .which is an important part of their income. . . .Private hospitals occupy an important position in the health service, and without their facilities it is unlikely that the state system could operate without substantial delays and waiting lists....There is peaceful coexistence between public and private systems; they operate side by side, without difficulty, and the Government gives every encouragement to citizens to use private facilities to the maximum.... Patients . . .who opt for private facilities receive a subsidy."(All the italics are mine.)These quotations are from a description of the health care system in the Irish Republic (by Mr R M Graham of the Voluntary Health Insurance Board in Dublin), which by coincidence reached me today also.The Englishman by tradition has derided the capability of the Irishman to think clearly.But it seems to me that the boot is on the other foot in this case.If any should say that this is all very well but such a sensible mixture of provision for those in need, with a subsidy for self-help, could not ever be accepted here, my reply is that there is abundant and consistent evidence, in repeated public opinion polls, that the majority-regardless of party or trade urion membership-are not ill disposed to a symbiotic health care system of this nature.
Intestinal Infarction in Paroxysmal Nocturnal Hemoglobinuria
Authors: Stuart F. Blum, Frank H. Gardner
Journal: New England Journal of Medicine (1966)

PAROXYSMAL nocturnal hemoglobinuria is an acquired disorder of unknown etiology and diverse manifestations. Most prominent among these, and the feature upon which the diagnosis is made, is the presence of a hemolytic anemia. The anemia, which results from an unknown intracorpuscular abnormality that sensitizes the erythrocytes of the patient to hemolysis in normal human serum,1 varies in severity but can usually be managed successfully with blood transfusions. Fatal complications arise from a tendency to widespread thrombosis. The etiology of this thrombotic tendency is also unclear, but the recently observed increased thrombin generation by plasma from the patients2 may be a . . .
Comprehensive ophthalmology at the Last Chance Saloon
Authors: Michael Clarke
Journal: BMJ (2005)

L et me let you into a secret. No one is in charge. No one knows what's going on.

I don't know how it is in your specialty, but in mine there is one man at the Department of Health who is supposed to know what's going on. He is a one man band in charge of “optical services.” That's 7000 optometrists and 1000 consultant ophthalmologists. My 100 colleagues in paediatric ophthalmology rate a few civil service digits.

The government of the day thinks in soundbites and spin. The soundbite for ophthalmology is waiting lists, cataracts, and private practice. That's not to say that cataracts are not important. The reason cataract surgery is the most commonly performed surgical procedure in …
Ubiquitination and Downregulation of BRCA1 by Ubiquitin-Conjugating Enzyme E2T Overexpression in Human Breast Cancer Cells
Authors: Tomomi Ueki, Jae-Hyun Park, Toshihiko Nishidate, Kyoko Kijima, Koichi Hirata, Yusuke Nakamura, Toyomasa Katagiri
Journal: Cancer Research (2009)

Breast cancer is generated through a multistep genetic and epigenetic process including activations of oncogenes and inactivations of tumor suppressor genes. Here, we report a critical role of ubiquitin-conjugating enzyme E2T (UBE2T), an E2 ubiquitin-conjugating enzyme, in mammary carcinogenesis. Immunocytochemical staining and in vitro binding assay revealed that UBE2T interacted and colocalized with the BRCA1/BRCA1-associated RING domain protein (BARD1) complex. Knocking down of UBE2T expression with small interfering RNA drastically suppressed the growth of breast cancer cells. Interestingly, in vivo ubiquitination assay indicated BRCA1 to be polyubiquitinated by incubation with wild-type UBE2T protein, but not with C86A-UBE2T protein, an E2 activity-dead mutant, in which the 86th residue of cysteine was replaced with alanine. Furthermore, knocking down of UBE2T protein induced upregulation of BRCA1 protein in breast cancer cells, whereas its overexpression caused the decrease of the BRCA1 protein. Our data imply a critical role of UBE2T in development and/or progression of breast cancer through the interaction with and the regulation of the BRCA1/BARD1 complex.
Fallen angels: how not to raise money for charity
Authors: J. H Jessop
Journal: BMJ (1985)

relatively little time available to talk to their inpatients because they are responsible for patients in several hospitals and are also concerned in work in the community, which may be particularly time consuming.Psychiatric firms usually have one junior trainee per site (or part ofone), and there are no housemen, so on call duties are shared by SHOs/registrars, whose posts usually coalesce to form training programmes involving enough firms and units to allow varied experience in a rotating scheme.Cuts in the numbers of junior psychiatric training posts are being proposed in many places and in some cases are draconian.If these numbers are reduced in this way without either a significant increase in consultant numbers or a commensurate increase in non-trainee junior posts then the standard of service may decline unacceptably in many places.Some regions err in supposing that manpower needs and use in psychiatry are essentially the same as in medical and surgical specialties.
Comparative developmental aspects of selected organ systems. II. Gastrointestinal and urogenital systems.
Authors: R M Hoar
Journal: Environmental Health Perspectives (1976)

A brief description of the basic patterns of mammalian organogenesis of the gastrointestinal and urogenital systems is presented based on events as they occur in human beings. The emphasis is not on the details of this development, but rather on its organization and timing, with tables of comparative development providing a comparison of similar events in man, rat, mouse, and chick.