Pentamidine and Hypoglycemia
Authors: JOHN K. MURDOCH
Journal: Annals of Internal Medicine (1983)

Letters and Corrections1 December 1983Pentamidine and HypoglycemiaJOHN K. MURDOCH, B.SC.PHM., JAY S. KEYSTONE, M.D.JOHN K. MURDOCH, B.SC.PHM.Search for more papers by this author, JAY S. KEYSTONE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-99-6-879_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The recent case of pentamidine-induced hypoglycemia reported by Sharpe (1) prompted a chart review of patients treated with pentamidine at the Toronto General Hospital during the period of 1973 to 1983. Six of fifteen adult patients developed hypoglycemia (fasting plasma glucose less than 3.3 mmol/L) while being treated with pentamidine for Pneumocystis carinii pneumonia.In comparison, the Parasitic Disease Drug Service, Centers for Disease Control (CDC), reported hypoglycemia in 25 (6.2%) of 404 patients treated with pentamidine (2). An earlier paper from the CDC reported hypoglycemia (blood glucose below 3.3 mmol/L) in 15 (9%) of 168 patients;...References1. SHARPE S. Pentamidine and hypoglycemia [Letter]. Ann Intern Med. 1983;99:128. LinkGoogle Scholar2. WALZERPERLKROGSTADRAWSONSCHULTZ PDDPM. Pneumocystis carinii pneumonia in the United States: epidemiologic, diagnostic, and clinical features. Ann Intern Med. 1974;80:83-93. LinkGoogle Scholar3. WESTERNPERERASCHULTZ KDM. Pentamidine isethionate in the treatment of Pneumocystis carinii pneumonia. Ann Intern Med. 1970;73:695-702. LinkGoogle Scholar4. HUGHESFELDMANCHAUDHARYOSSICOXSANYAL WSSMFS. Comparison of pentamidine isethionate and trimethoprim-sulfamethoxazole in the treatment of Pneumocystis carinii pneumonia. J Pediatr. 1978;92:285-91. CrossrefMedlineGoogle Scholar5. BOUCHARDSAIREACHCAUBARREREGANEVALASSAN PPGIDR. Diabetes mellitus following pentamidine-induced hypoglycemia in humans. Diabetes. 1982;31:40-5. CrossrefMedlineGoogle Scholar1. SHARPE S. Pentamidine and hypoglycemia [Letter]. Ann Intern Med. 1983;99:128. LinkGoogle Scholar2. FITZGERALDYOUNG DI. Reversal of pentamidine induced hypoglycemia with oral diazoxide. J Trop Med Hygiene. (In press). Google Scholar3. BOUCHARDSAIREACH PPI. Diabetes mellitus following pentamidine induced hypoglycemia in humans. Diabetes. 1982;31:40-5. CrossrefMedlineGoogle Scholar4. WESTERNPERRERASCHULTZ KDM. Pentamidine isethionate in the treatment of Pneumocystis carinii pneumonia. Ann Intern Med. 1970;73:695-702. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOHN K. MURDOCH, B.SC.PHM.; JAY S. KEYSTONE, M.D.Affiliations: Toronto General Hospital Toronto Canada PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNinety Years of Pentamidine: The Development and Applications of Pentamidine and its AnalogsSulfonamides, sulfadiazine, trimethoprim-sulfamethoxazole, pentamidine, pyrimethamine, dapsone, quinolonesThe effect of inducing agents on the metabolism of trypanocidal diamidines by isolated rat hepatocytesSulfonamides, sulfadiazine, trimethoprim-sulfamethoxazole, pentamidine, pyrimethamine, dapsone, quinolones1,5-Bis(4-amidinophenoxy)pentane (pentamidine) is a potent inhibitor of []idazoxan binding to imidazoline I2 binding sitesMiscellaneous drugs with nephrotoxic potential (Sulfonamides, sulfadiazine, trimethoprim-sulfamethoxazole, pentamidine, pyrimethamine, dapsone, quinolones)Poussée aiguë d'insuffisance rénale chronique après aérosol de pentamidine chez un patient infecté par le VIHAcquired Immunodeficiency SyndromeInfluence of Pentamidine and Two New Trypanocidal Agents (DAPI, DIPI) on Liver Metabolism of MiceInvestigations on mutagenicity and genotoxicity of pentamidine and some related trypanocidal diamidinesPneumocystis cariniiHypoglycemic coma from pentamadine in an AIDS patient 1 December 1983Volume 99, Issue 6Page: 879-879KeywordsBloodBlood plasmaChartsDrug regulationDrugsGlucoseHypoglycemiaParasitic diseasesPneumocystis carinii pneumonia ePublished: 1 December 2008 Issue Published: 1 December 1983 PDF downloadLoading ...