Adrenal Secretion After Bilateral Adrenalectomy for Cushing's Syndrome
Authors: GEORGE P. KOZAK
Journal: Annals of Internal Medicine (1966)

Article1 April 1966Adrenal Secretion After Bilateral Adrenalectomy for Cushing's SyndromeGEORGE P. KOZAK, M.D., GEORGE L. PAUK, M.D., ANTHONY I. VAGNUCCI, M.D., DAVID P. LAULER, M.D., GEORGE W. THORN, M.D., F.A.C.P.GEORGE P. KOZAK, M.D.Search for more papers by this author, GEORGE L. PAUK, M.D.Search for more papers by this author, ANTHONY I. VAGNUCCI, M.D.Search for more papers by this author, DAVID P. LAULER, M.D.Search for more papers by this author, GEORGE W. THORN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-4-778 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe availability of oral steroid replacement therapy has elevated total bilateral adrenalectomy to the treatment of choice in Cushing's syndrome associated with bilateral adrenal hyperplasia. The development of adrenocorticotrophic hormone (ACTH)-producing pituitary tumors following total adrenalectomy for Cushing's syndrome, despite normal steroid replacement therapy, has constituted a complication in approximately 4 to 5% of such patients (1-3). Recently, another perplexing and frustrating problem has emerged, namely the persistence of continued steroidogenesis despite the complete removal of both adrenals and pituitary irradiation. The difficulties in attempting to identify and remove remnants or accessory foci of adrenal tissue, particularly in previously operated...References1. NELSONMEAKINDEALYMATSONEMERSONTHORN DHJWJBDDKGW: ACTH-producing tumor of the pituitary gland. New Eng. J. Med. 259: 161, 1958. CrossrefMedlineGoogle Scholar2. SALASSAKEARNSKERNOHANSPRAGUEMACCARTY RMRPJWRGCS: Pituitary tumors in patients with Cushing's syndrome. J. Clin. Endocr. 19: 1523, 1959. CrossrefMedlineGoogle Scholar3. NELSONMEAKINTHORN DHJWGW: ACTH-producing pituitary tumors following adrenalectomy for Cushing's syndrome. Ann. Intern. Med. 52: 560, 1960. LinkGoogle Scholar4. SOFFERDORFMANGABRILOVE LJRIJL: The Human Adrenal Gland. Lea & Febiger, Philadelphia, 1961. Google Scholar5. GRAHAM LS: Celiac accessory adrenal glands. Cancer 6: 149, 1953. CrossrefGoogle Scholar6. COPERAKER OJW: Cushing's disease. New Eng. J. Med. 253: 119, 165, 1955. CrossrefMedlineGoogle Scholar7. CHAFFEEMOSESLLOYDROGERS WRAMCWLS: Cushing's syndrome with accessory adrenocortical tissue. JAMA 186: 799, 1963. CrossrefMedlineGoogle Scholar8. WEBERDITZEL JJ: Effect of long-term administration of metyrapone and dexamethasone in a patient with Cushing's syndrome. Acta Endocr. (Kobenhavn) 43: 493, 1963. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, MassachusettsFrom the Department of Medicine, the Harvard Medical School, and the Peter Bent Brigham Hospital, Boston, Mass.This study was supported in part by the John A. Hartford Foundation (grant 9893), U. S. Public Health Service grant 9832-9, Bethesda, Md., and the Endocrine Training Grant 8416-2.Requests for reprints should be addressed to George W. Thorn, M.D., 721 Huntington Ave., Boston, Mass. 02115. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByThree Endocrine Neoplasms: An Unusual Combination of Pheochromocytoma, Pituitary Adenoma, and Papillary Thyroid CarcinomaUrinary excretion of corticosterone metabolites in demonstrating the adrenocortical remnantAdrenal Insufficiency Attributable to Adrenal Hemorrhage: Long-Term Follow-Up with Reference to Glucocorticoid and Mineralocorticoid Function and ReplacementDAdrenal CortexRESIDUAL ADRENOCORTICAL FUNCTION AFTER BILATERAL "TOTAL" ADRENALECTOMY FOR CUSHING'S DISEASECushing's syndrome secondary to a neuroendocrine tumor: Relapse after bilateral adrenalectomyDie NebennierenrindeProblems in the Diagnosis of Cushing's SyndromeAdrenal CortexA radioimmunoassay of androstenedioneLeft Adrenal Aldosterone Producing Tumor with a Congenitally Absent Right Adrenal Gland 1 April 1966Volume 64, Issue 4Page: 778-785KeywordsAdrenalectomyAdrenocorticotropic hormoneHospital medicineMedical servicesPituitary tumorsRegenerative medicineSteroid therapySteroidogenesis Issue Published: 1 April 1966 PDF DownloadLoading ...