tbuckley/cabot-search huggingface dataset:
Myocardial metabolism during increased work states in the porcine left ventricle in vivo.
Authors: B M Massie, G G Schwartz, J Garcia, J A Wisneski, M W Weiner, T Owens
Journal: Circulation Research (1994)

It is not known whether myocardial energy requirements can be increased to the degree that they exceed myocardial O2 availability in the absence of abnormalities of coronary blood flow or coronary reserve. To determine whether this form of "demand ischemia" occurs, 10 swine were subjected to pressure overload induced by aortic constriction, inotropic and chronotropic stimulation by dobutamine, and the combination of these interventions. In an additional 9 animals, intravenous adenosine was administered during the combination of constriction and dobutamine to determine whether further increases in coronary flow could be achieved and if they would attenuate the metabolic changes. Left ventricular anterior wall transmural blood flow was measured by radioactive microspheres. Energy phosphates were assessed by 31P magnetic resonance spectroscopy using the Fourier series window technique to increase the proportion of signal derived from the subendocardium. Myocardial lactate release was quantified independent of net lactate uptake using an isotopic tracer technique. The three interventions produced 39% to 195% increases in myocardial O2 uptake from control measurements. The phosphocreatine to ATP ratio (PCr/ATP), uncorrected for partial saturation, fell significantly, from 1.39 +/- 0.10 at control conditions to 1.25 +/- 0.10 with dobutamine alone and 1.15 +/- 0.08 with dobutamine plus constriction (P &lt; .05 for both). Myocardial lactate release rose from 0.21 +/- 0.03 mumol.g-1.min-1 at control conditions to 0.45 +/- 0.05 and 0.59 +/- 0.10 mumol.g-1.min-1, respectively (P &lt; .05 for both), with these two interventions. Although transmurally averaged left ventricular blood flow rose from 0.97 +/- 0.09 mL.g-1.min-1 at control conditions to 3.25 +/- 0.47 mL.g-1.min-1 (P &lt; .001) and subendocardial blood flow increased from 1.02 +/- 0.09 to 2.92 +/- 0.45 mL.g-1.min-1 (P &lt; .001) at the highest of the three increased work states, the subendocardial to subepicardial flow ratio declined progressively from 1.13 +/- 0.08 to 0.87 +/- 0.04 (P &lt; .05). With a further increase in aortic constriction, myocardial O2 uptake and subepicardial blood flow rose, whereas subendocardial blood flow did not change, and there was a further decline in PCr/ATP and a rise in lactate release. Although adenosine increased the average myocardial blood flow during high work state from 3.79 +/- 0.91 to 6.29 +/- 1.08 mL.g-1.min-1 (P &lt; .001), the further rise in subendocardial flow from 3.08 +/- 0.62 to 3.78 +/- 0.68 mL.g-1.min-1 was not significant, nor were the accompanying changes in PCr/ATP or lactate metabolism.(ABSTRACT TRUNCATED AT 400 WORDS)
Long-term functional reconstruction of segmental tracheal defect by pedicled tissue-engineered trachea in rabbits
Authors: Xusong Luo, Yi Liu, Zhiyong Zhang, Ran Tao, Yu Liu, Aijuan He, Zongqi Yin, Dan Li, Wenjie Zhang, Wei Liu, Yilin Cao, Guangdong Zhou
Journal: Biomaterials (2013)
China Doctor: The Life Story of Harry Willis Miller
Authors: Franklin D. Yoder
Journal: JAMA (1961)

The AMA, with its new Department of International Health, is focusing interest on aid to medical missionaries. This book concerns one of the most prominent missionaries in the medical field. In this review it would not be the best use of space to recount the many vicissitudes of a young physician whose missionary zeal leads him to China soon after the turn of the century. The book, although it could be in better literary style, accurately recounts life and its environment (sanitation descriptions are especially vivid) as it was in these years on this remote part of the globe. The important thing to the reader is accurate depiction of Chinese life and culture which helps one to understand today's problems which are at least equally pressing. It should also be said that Dr. Miller's medical efforts were felt at all levels in the Chinese social hierarchy. His medical missionary efforts
CATH LAB UTILIZATION DURING TRANSITION TO THE RADIAL ARTERY AS PREFERRED ACCESS: THE WAKE FOREST ACADEMIC MEDICAL CENTER EXPERIENCE
Authors: Samuel Turner, Matthew T. Sacrinty, William C. Little, Sanjay K. Gandhi, Michael A. Kutcher, Renato M. Santos, Michael R. Manogue, Robert J. Applegate
Journal: Journal of the American College of Cardiology (2011)
More Heart Transplants — Dial-a-Doctor — Parliamentary Report — Dr. Franz Ingelfinger
Authors: John Lister
Journal: New England Journal of Medicine (1980)

TWO cardiac surgical units in Britain have embarked on new programs for cardiac transplantation: one is at Papworth Hospital, East Anglia, where the surgeon in charge is Mr. Terence English, and the other is at Harefield Hospital, Middlesex, where the surgeon is Mr. Magdy Yacoub.So far 11 transplantations have been carried out in this series. The one immediate postoperative death occurred at Harefield in the only female patient in the series, and one of the male patients at Harefield died after the development of signs of rejection.There has been much public interest in this resumption of cardiac transplantation, . . .
Characterization of thymus-derived lymphocytes expressing Ti alpha-beta CD3 gamma delta epsilon zeta-zeta, Ti alpha-beta CD3 gamma delta epsilon eta-eta or Ti alpha-beta CD3 gamma delta epsilon zeta-zeta/zeta-eta antigen receptor isoforms: analysis by gene transfection.
Authors: L K Clayton, A Bauer, Y J Jin, L D'Adamio, S Koyasu, E L Reinherz
Journal: The Journal of Experimental Medicine (1990)

To characterize the function of the CD3 eta subunit of the T cell receptor (TCR), we have used cDNAs encoding CD3 zeta, CD3 eta, or both to reconstitute a variant of a cytochrome c-specific, I-Ek-restricted murine T cell hybridoma, termed MA5.8, which lacks CD3 zeta and CD3 eta proteins. We provide direct evidence that assembly and surface expression of TCRs can be mediated by either of these subunits separately or together. However, the level of TCR expression on zeta transfectants is up to one order of magnitude greater than that on eta transfectants, implying that CD3 eta is weakly associated with the pentameric Ti alpha-beta CD3 gamma delta epsilon complex and/or inefficient at salvaging the incomplete TCR from lysosomal degradation. As a component of the TCR, the CD3 eta subunit preferentially forms a heterodimer with CD3 zeta, but is also able to form a CD3 eta-eta homodimer. Crosslinking of Ti alpha-beta CD3 gamma delta epsilon zeta-zeta, Ti alpha-beta CD3 gamma delta epsilon eta-eta, or Ti alpha-beta CD3 gamma delta epsilon zeta-zeta/zeta-eta TCR isotypes with anti-CD3 epsilon monoclonal antibody or a cytochrome c peptide epitope on I-Ek antigen-presenting cells mediates signal transduction resulting in reversible cell-cycle arrest of transfected clones. Given the potential for diversity of signals generated by these functional TCR isotypes and the expression of the CD3 eta gene product in the thymus, CD3 eta is likely to play a role in selection and/or activation of thymocytes during development.
Splenic Rupture in Infectious Mononucleosis
Authors: D. P. Fossard
Journal: BMJ (1966)

MEBICLJON 49 practice the diagnosis of hysteria has as much discriminating value as one of headache.Slater's most unreasonable conclusion was that the concept of hysteria is at fault.It should be noted that it is not Slater but Sir Francis Walshe who, by opposing this view, impugns the diagnostic competence of neurologists.
Multiple<i>BRAF</i>Wild-Type Melanomas During Dabrafenib Treatment for Metastatic<i>BRAF</i>-Mutant Melanoma
Authors: Cristina Carrera, Joan A. Puig-Butillè, Gemma Tell-Marti, Adriana García, Celia Badenas, Llucia Alós, Susana Puig, Josep Malvehy
Journal: JAMA Dermatology (2015)

BRAF inhibitors have become the standard of care in metastatic BRAF-mutant melanomas. Compared with chemotherapies, BRAF inhibitors improve overall and disease-free survival and speed the recovery of symptomatic patients with metastatic disease. The most worrisome finding is the possible development of resistance to new malignant tumors.A patient in her 30s developed massive BRAFV600E melanoma metastasis during her 30th week of pregnancy. After emergency cesarean delivery, oral dabrafenib treatment was initiated, and a partial radiologic response was confirmed within 1 month. At dermatologic digital follow-up aided by confocal microscopy 8 weeks after initiation of dabrafenib treatment, 4 melanomas were detected. Unfortunately, within the next month, the melanoma rapidly progressed. The 4 new melanomas were wild-type BRAFmelanomas, whereas the new metastasis carried a different BRAF mutation (S467L).Cutaneous malignant tumors are the most frequent adverse events of BRAF inhibitors; therefore, strict dermatologic surveillance in a referral center aided by digital follow-up is mandatory, especially when multiple nevi are present and these drugs are used in an adjuvant setting. In view of our findings, the pathogenesis of the development of new melanomas seems to be different from therapy resistance. Whether paradoxical RAF activation could explain these BRAF wild-type secondary malignant tumors is still unknown.
Effect of continuous jejunal perfusion of elemental and complex nutritional solutions on pancreatic enzyme secretion in human subjects.
Authors: N Vison, P Hecketsweiler, J Butel, J J Bernier
Journal: Gut (1978)

Pancreatic secretion of lipase and chymotrypsin in response to elemental diets and a crushed food homogenate was studied in normal subjects. The solutions were infused at constant flow rates at the ligament of Treitz with polyethylene glycol as a nonabsorbable marker. A triple lumen tube was used, enabling collection of secretions at 35 and 70 cm from the infusion point. The results show that a crushed food homogenate has a greater stimulative effect on pancreatic enzyme secretion than the elemental solutions and that this can be directly related to its greater nitrogen content. The osmolality of the infused solutions does not appear to be important. The relative merits of the solutions tested and total parental nutrition in reducing pancreatic enzyme secretion are discussed.
Bismuth Treatment of Rheumatoid Arthritis
Authors: A. H. Douthwaite
Journal: BMJ (1944)

Routine gargling had no effect in reducing the carrier rate during the epidemic.A comparison is made with a similar type of outbreak which occurred in an American Army camp.I wish to tender thanks to Dr. N. Crowley for the help she gave me in the bacteriological investigation of throat swabs, etc.
A COMPARISON OF SOME PHYSICAL PROPERTIES OF FOUR VEHICLES USED IN DERMATOLOGICAL PREPARATIONS*
Authors: B. S. BAKER, R. B. FOUNTAIN, J. W. HADGRAFT, I. SARKANY
Journal: British Journal of Dermatology (1969)

SUMMARY.— The rate of diffusion of methyl nicotinate in water, tetrahydrofurfuryl alcohol, propylene glycol and polyethylene glycol 300 has been investigated using optical density as a measure of the concentration of methyl nicotinate. The volatility and affinity for water, viscosities and surface tensions of these solvents have also been studied. The relationship between these physical properties and the influence of the solvent on the vasodilator response to methyl nicotinate is discussed.
Points from Letters: Mallory-Weiss Syndrome
Authors: A. M. Hoare
Journal: BMJ (1974)

Mileage for Consultants SIR,-In your footnote to the letter from Dr. M. C. C. Bird (11 May, p. 336) you quote the Secretary as saying that the mileage allowances in the N.H.S. have been increased three times since last December.Readers may like to know what these princely increases were.The allowance was first increasod from 5 5p to 5 6p and then to 5-7p; and
Obstacles to health in the Arab world
Authors: J Makhoul, F El-Barbir
Journal: BMJ (2006)

Obstacles to health in the Arab worldEditor-Health indicators in the Arab world show stark differences between individual countries.But aggregate figures provide only a narrow perspective.They do not show variation according to socioeconomic group, sex, education, or political affiliation.The scarcity of databases available to collect such detailed data reflects the fact that inadequate political support exists for rigorous intersectoral research of relevance for health in the region.National development agendas and public policies are focused on economic development.Funding for health tends largely to be directed at providing curative medical services designed to emulate Western health systems. 1 Patriarchal and religious principles embedded in the state structures of many Arab countries-such as Lebanon, Egypt, and Saudi Arabia-are a further obstacle to unpicking and taking action to tackle poor health and health inequity in the region.The conservative values of the Arab world render public debates about religion, politics, and sexuality unacceptable and place social stigma around drug users, commercial sex workers, and mentally ill people.As a result, health data on such groups are limited and unreliable, 2 which presents an obstacle for the development of appropriate services.Although national cultural, social, and economic structures are to blame for patchy and inequitable public health services, particularly in Egypt, Morocco, and Lebanon, 3 regional and global forces influence health provision too.The Arab-Israeli conflict, the wars in Iraq, the Gulf, Lebanon, Yemen, and Sudan have brought about hunger, epidemics, displacement, and death.These wars have been tacitly bolstered by multinational corporations, which have sold billions of dollars worth of weapons to Arab countries in conflict.Governments' expenditures on defence in some Arab countries are greater than their expenditure on health. 4 International political action (and inaction), notably in Iraq and Lebanon, has played a part too.Similarly, global decisions have led to fluctuations of funding for the United Nations Relief and Works Agency (UNRWA), the leading health and social service provider to Palestinian refugees. 5 Multilateral and bilateral aid has also influenced public policy making in many economies of the Arab world, owing to demands for reform and reduced public sector spending.These have had a dispro-portionate effect on low income groups.Although several Arab countries have banned tobacco advertisements, tobacco companies continue to reach Arab homes through satellite television stations, another global feature.Tobacco related mortality is expected to reach 0.5 million deaths in the Arab world by 2020.Further investigation of the ways that powerful regional and global agents effect health in the Arab world and beyond is crucial for a clearer perspective on obstacles to health.Only then will the possibility of advocacy for lasting health see the light.
Rationale for Antiangiogenic Cancer Therapy with Vaccination Using Epitope Peptides Derived from Human Vascular Endothelial Growth Factor Receptor 2
Authors: Satoshi Wada, Takuya Tsunoda, Toshiyuki Baba, F. James Primus, Hiroyuki Kuwano, Masabumi Shibuya, Hideaki Tahara
Journal: Cancer Research (2005)

Angiogenesis is a critical mechanism for tumor progression. Multiple studies have suggested that tumor growth can be suppressed if tumor angiogenesis can be inhibited using various types of antiangiogenic agents. Recent studies in mouse systems have shown that tumor angiogenesis can also be inhibited if cellular immune response could be induced against vascular endothelial growth factor receptor 2 (VEGFR2), which is one of the key factors in tumor angiogenesis. In this study, we examined the possibility of developing this novel immunotherapy in clinical setting. We first identified the epitope peptides of VEGFR2 and showed that stimulation using these peptides induces CTLs with potent cytotoxicity in the HLA class I-restricted fashion against not only peptide-pulsed target cells but also endothelial cells endogenously expressing VEGFR2. In A2/Kb transgenic mice that express alpha1 and alpha2 domains of human HLA-A*0201, vaccination using these epitope peptides in vivo was associated with significant suppression of the tumor growth and prolongation of the animal survival without fatal adverse effects. In antiangiogenesis assay, tumor-induced angiogenesis was significantly suppressed with the vaccination using these epitope peptides. Furthermore, CTLs specific to the epitope peptides were successfully induced in cancer patients, and the specificities of the CTLs were confirmed using functional and HLA-tetramer analysis. These results in vitro and in vivo strongly suggest that the epitope peptides derived from VEGFR2 could be used as the agents for antiangiogenic immunotherapy against cancer in clinical settings.
Schizophrenia in a male pseudohermaphrodite.
Authors: K. L. Trick
Journal: BMJ (1967)

There now exists a considerable literature concerning intersex states in humans.Money (1952), reviewing the literature and studying a personal series of cases, found only one case with coexistent schizophrenia.Subsequently a further patient in this group was also diagnosed as schizophrenic (Money, per- sonal communication).No further cases seem to have been reported in the interim. CASE REPORTA man aged 44 was admitted to hospital for investigation in March 1964, his only complaint being of fatigue, which he felt was related to poisons circulating in his blood stream after an attack of " chorea " at the age of 14.He stated that at birth he had been registered as a girl and had been reared as such until the age of 14, when he was admitted to the local mental hospital suffering from " chorea with mania."
Thymic stromal lymphopoietin activity is increased in nasal polyps of patients with chronic rhinosinusitis
Authors: Deepti R. Nagarkar, Julie A. Poposki, Bruce K. Tan, Michael R. Comeau, Anju T. Peters, Kathryn E. Hulse, Lydia A. Suh, James Norton, Kathleen E. Harris, Leslie C. Grammer, Rakesh K. Chandra, David B. Conley, Robert C. Kern, Robert P. Schleimer, Atsushi Kato
Journal: Journal of Allergy and Clinical Immunology (2013)
Urinoma Detected by Dual Isotope Renogram-Cystogram
Authors: ALFRED L. BAKER, ROBERT J. COWAN, DEAN G. ASSIMOS
Journal: Clinical Nuclear Medicine (1987)

A case is reported in which a urinoma developed following a renal transplant. Dual isotope renographycystography using Tc-99m DTPA and Ga-67 citrate revealed the diagnosis after ultrasonography and radiographic cystography were nondiagnostic.
Russia declares "total war" on the country's drug problem
Authors: A. Osborn
Journal: BMJ (2011)

The Kremlin has declared what it calls a “total war” on Russia’s drug problem and is drawing up changes in the law that would give drug addicts a stark choice: forced treatment or jail.

In a move that harks back to the Soviet Union’s hardline approach to the problem, the government says it also wants to treat drug dealers “like serial killers” and jail them for life, forcing them to toil in harsh labour camps.

“There is no time to lose. Our self preservation is at stake,” said Boris Gryzlov, the speaker of Russia’s lower house of parliament and a senior figure in the ruling United Russia party. …
99mTc-pyrophosphate imaging in patients with acute myocardial infarction: comparison of planar imaging with single-photon tomography with and without blood pool overlay.
Authors: J R Corbett, M Lewis, J T Willerson, P H Nicod, R L Huxley, T Simon, R E Rude, E Henderson, R Parkey, J S Rellas
Journal: Circulation (1984)

To test the hypothesis that single-photon emission computed tomography (SPECT) of 99mTc-pyrophosphate (99mTc-PPi) with and without the overlay of tomographic blood pool scintigrams might detect small infarcts not identified by planar imaging, 52 patients were studied 3.2 +/- 2.0(SD) days after hospital admission for suspected acute myocardial infarction. Patients were chosen prospectively for tomographic study primarily, but not exclusively, because planar four-view imaging with 99mTc-PPi was either negative or equivocal. SPECT was performed with a commercial rotating detector system immediately after planar imaging on one occasion. Corresponding 99mTc-PPi and blood pool sections were mapped into opposite halves of a bichromic color table and displayed as an overlay. Planar images, SPECT and SPECT with blood pool overlay were interpreted separately and in random order without knowledge of clinical data. Seventeen patients had transmural infarcts (four anterior, 13 inferior), 19 had nontransmural infarcts, and 16 patients did not have acute myocardial infarction. The sensitivity of SPECT with blood pool overlay was significantly better than planar imaging for the entire group with myocardial infarction (97% vs 78%; p less than .025); this was primarily due to increased sensitivity in the detection of nontransmural myocardial infarction (95% vs 67%; p less than .05), although in one additional patient inferior transmural myocardial infarction was also detected by the SPECT overlay technique. The specificities of the SPECT overlay technique and planar imaging were not significantly different; however, receiver operating characteristic analysis showed enhanced observer confidence with the tomographic method. SPECT without overlay was intermediate in sensitivity and specificity.(ABSTRACT TRUNCATED AT 250 WORDS)
RNAi-mediated silencing of TEL/AML1 reveals a heat-shock protein– and survivin-dependent mechanism for survival
Authors: Christofer Diakos, Gerd Krapf, Christopher Gerner, Andrea Inthal, Christof Lemberger, Jozef Ban, Alexander M. Dohnal, E. Renate Panzer-Grümayer
Journal: Blood (2006)
Graves' disease: immunological and immunogenetic indicators of relapse
Authors: T W A de Bruin, J H Bolk, J K Bussemaker, T Stijnen, G M T Schreuder, R R P de Vries, D van der Heide
Journal: BMJ (1988)

The use of measurements of antibody to the thyroid stimulating hormone receptor and HLA-DR3 phenotype for predicting relapse of hyperthyroidism in patients with Graves9 disease receiving medical treatment is controversial. Fifty eight new patients with Graves9 disease were followed up prospectively for up to 96 months after treatment with antithyroid drugs for 12 months. The presence of antibody to the thyroid stimulating hormone receptor before the start of treatment, measured as immunoglobulins inhibiting binding of thyroid stimulating hormone, was not associated with relapse. Patients who remained positive for antibodies after treatment tended to relapse within six months, but no relation with long term relapse was found. HLA-Cw7 but not HLA-DR3 was significantly associated with relapse. The presence of HLA-DR4 was significantly associated with remission and with absence of antibodies to thyroid stimulating hormone receptor. HLA-DR4 may therefore protect against relapse of thyrotoxicosis by immunomodulation triggered by antithyroid drugs, which results in the synthesis of antibodies to the thyroid stimulating hormone receptor being inhibited.
Spectinamides: a new class of semisynthetic antituberculosis agents that overcome native drug efflux
Authors: Richard E Lee, Julian G Hurdle, Jiuyu Liu, David F Bruhn, Tanja Matt, Michael S Scherman, Pavan K Vaddady, Zhong Zheng, Jianjun Qi, Rashid Akbergenov, Sourav Das, Dora B Madhura, Chetan Rathi, Ashit Trivedi, Cristina Villellas, Robin B Lee, None Rakesh, Samanthi L Waidyarachchi, Dianqing Sun, Michael R McNeil, Jose A Ainsa, Helena I Boshoff, Mercedes Gonzalez-Juarrero, Bernd Meibohm, Erik C Böttger, Anne J Lenaerts
Journal: Nature Medicine (2014)