Lipid Emulsion Therapy for Verapamil Overdose
Authors: Timothy J. Franxman, Moutaz Al-Nabhan, Rodrigo S. Cavallazzi, Aaron J. Speak
Journal: Annals of Internal Medicine (2011)

Letters15 February 2011Lipid Emulsion Therapy for Verapamil OverdoseTimothy J. Franxman, MD, Moutaz Al-Nabhan, MD, Rodrigo S. Cavallazzi, MD, and Aaron J. Speak, PharmDTimothy J. Franxman, MDFrom University of Louisville and University of Louisville Hospital, Louisville, KY 40202., Moutaz Al-Nabhan, MDFrom University of Louisville and University of Louisville Hospital, Louisville, KY 40202., Rodrigo S. Cavallazzi, MDFrom University of Louisville and University of Louisville Hospital, Louisville, KY 40202., and Aaron J. Speak, PharmDFrom University of Louisville and University of Louisville Hospital, Louisville, KY 40202.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-154-4-201102150-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Background: In 2005, Tebbutt and colleagues (1) showed that lipid emulsion therapy provided a survival advantage in rats that received toxic doses of verapamil. Four years later, lipid emulsion was used to manage a human patient with verapamil overdose (2).Objective: To describe the use of lipid emulsion in the management of a patient with verapamil overdose.Case Report: A 39-year-old woman with chronic hypertension took 17 tablets of extended-release verapamil, 240 mg (total dose, 4.08 g), at 1:00 a.m. She developed dyspnea, tightness of the chest, and drowsiness and came to our emergency department at 2:32 a.m. On physical ...References1. Tebbutt S, Harvey M, Nicholson T, Cave G. Intralipid prolongs survival in a rat model of verapamil toxicity. Acad Emerg Med. 2006;13:134-9. [PMID: 16436797] CrossrefMedlineGoogle Scholar2. Young AC, Velez LI, Kleinschmidt KC. Intravenous fat emulsion therapy for intentional sustained-release verapamil overdose. Resuscitation. 2009;80:591-3. [PMID: 19282085] CrossrefMedlineGoogle Scholar3. Arroyo AM, Kao LW. Calcium channel blocker toxicity. Pediatr Emerg Care. 2009;25:532-8. [PMID: 19687715] CrossrefMedlineGoogle Scholar4. Sirianni AJ, Osterhoudt KC, Calello DP, Muller AA, Waterhouse MR, Goodkin MB, et al. Use of lipid emulsion in the resuscitation of a patient with prolonged cardiovascular collapse after overdose of bupropion and lamotrigine. Ann Emerg Med. 2008;51:412-5. [PMID: 17766009] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From University of Louisville and University of Louisville Hospital, Louisville, KY 40202.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByPilot Trial of Intravenous Lipid Emulsion Treatment for Severe Nifedipine-Induced ShockUse of Intravenous Fat Emulsion in the Emergency Department for the Critically Ill Poisoned PatientSystematic review of the effect of intravenous lipid emulsion therapy for non-local anesthetics toxicityLipid Rescue for Local Anesthetic and Nonlocal Anesthetic Drug ToxicityIntravenous Lipid Emulsion in the Emergency Department: A Systematic Review of Recent LiteratureTreatment for calcium channel blocker poisoning: A systematic reviewReview of the Use of Lipid Emulsion in Nonlocal Anesthetic PoisoningToxicologic Emergencies in the Intensive Care UnitAmlodipine Fatality in an Infant with Postmortem Blood Levels 15 February 2011Volume 154, Issue 4Page: 292KeywordsCalciumDopamineDrug therapyLipidsNorepinephrineOxygenResearch laboratoriesSaline solutionsThorax ePublished: 15 February 2011 Issue Published: 15 February 2011 CopyrightCopyright © 2011 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...