tbuckley/cabot-search huggingface dataset:
PD4-1-6: Acute esophageal reactions from proton beam therapy and concurrent chemotherapy for non-small cell lung cancer (NSCLS): Reduction in incidence and severity despite higher doses
Authors: James D. Cox, Joe Chang, Zhongxing Liao, M.K. Bucci, Mary F. McAleer, Xiong Wei, Pamela K. Allen, Haihong Cai, Michael T. Gillin, R Zhu, Narayan Sahoo, Shiao Y. Woo, Ritsuko Komaki
Journal: Journal of Thoracic Oncology (2007)
Effect of long term hormone replacement on plasma prolactin concentrations in women after oophorectomy.
Authors: D H Barlow, G H Beastall, H I Abdalla, J Elias-Jones, R Lindsay, D M Hart
Journal: BMJ (1985)

Plasma prolactin concentrations were studied in 88 oophorectomised women who had been receiving mestranol or placebo for three to 11 years. Thirty one of them were also studied under basal conditions and by tests with thyrotrophin releasing hormone. Under basal conditions the mean prolactin concentration was higher in the oestrogen treated group but under non-rested, clinic conditions the difference was lost because of a rise in prolactin value in the placebo group only. Hence the groups showed a different prolactin response to the mild stress of clinic attendance but the same proportionate responsiveness to thyrotrophin releasing hormone. The data suggest that long term hormone replacement has no significant effect on circulating prolactin concentrations under non-rested, everyday conditions and that the prolactin stimulating effects of minor stress and oestrogen may share a similar mechanism.
Septic arthritis caused by Moraxella catarrhalis associated with infliximab treatment in a patient with undifferentiated spondarthritis
Authors: I Olivieri
Journal: Annals of the Rheumatic Diseases (2003)

heumatoid arthritis (RA) is a chronic inflammatory disease which is characterised mainly by synovial inflammation and joint destruction, as well as extraarticular manifestations. 1 Cytokines have a central role in the pathogenesis of this synovial inflammation.Tumour necrosis factor a (TNFa) is one of the dominant cytokines.Many studies have shown that TNFa is present in biologically significant amounts in RA synovial tissue and fluids, and the amount seems to parallel the extent of inflammation and bone erosion. 2 3 Persistent inflamed monarthritis in patients with RA is difficult to treat.Usually it is treated with local patches, intraarticular injections of steroids, or even with chemical, radioactive, or surgical synovectomy. 4 The introduction of anti-TNFa treatments, especially the infusion of infliximab, 5 prompted us to investigate the effectiveness and safety of intra-articular injection of infliximab in patients with RA and resistant monarthritis.
The impact of the apolipoprotein E polymorphism on the lipoprotein profile in insulin-dependent diabetes: The pittsburgh epidemiology of diabetes complications study IX
Authors: June E. Eichner, Robert E. Ferrell, Mohammad I. Kamboh, Lewis H. Kuller, Dorothy J. Becker, Allan L. Drash, Evan A. Stein, Trevor J. Orchard
Journal: Metabolism (1992)
The relationship between post-onset pregnancy and functional outcome in women with recent onset inflammatory polyarthritis: results from the Norfolk Arthritis Register
Authors: E. M. Camacho, T. M. Farragher, M. Lunt, S. M. M. Verstappen, D. Bunn, D. P. M. Symmons
Journal: Annals of the Rheumatic Diseases (2010)

<h3>Objective</h3> To examine the influence of post-symptom-onset pregnancy on disease outcome in women with inflammatory polyarthritis (IP). <h3>Methods</h3> A total of 631 women, aged &lt;48 years at symptom onset, were registered with the Norfolk Arthritis Register (NOAR) between 1990 and 2004. Functional disability was assessed using the Stanford Health Assessment Questionnaire (HAQ). Blood was tested for rheumatoid factor (RF) and anti-cyclic citrullinated peptide antibody (ACPA). The date and outcome of all pregnancies were reported during a median follow-up of 7 years. Linear random effects models were used to examine HAQ score over time, by pregnancy status. Results were then stratified for RF and ACPA status. <h3>Results</h3> In all, 72 women had a post-onset pregnancy (Po-P) including 45 women who were pregnant at a follow-up assessment. Pregnancy was generally associated with lower HAQ scores over time than non-pregnancy. The 10 ACPA-positive women who had a Po-P had significantly worse subsequent HAQ scores. <h3>Conclusion</h3> Overall, Po-P is associated with lower HAQ scores, compared to no Po-P. This may reflect a beneficial effect of pregnancy on disease outcome, or that predominantly women with milder disease become pregnant. In women with the worst predicted outcome (APCA positive), Po-P is associated with a worse outcome than no pregnancy.
Knowledge is not a disease
Authors: I O Azuonye
Journal: BMJ (1994)

EDITOR, - I found Graham Hills's editorial on knowledge surprising for many reasons.1 Firstly, Hills uses such terms as “knowledge,” “learning,” “skills,” and “reality” without defining them or making clear the denotations he applies to them. I do not believe that Hills intended a discourse on the theory of knowledge,2,3 but he should have made clear that he was writing about theoretical knowledge …
An evolutionarily conserved PTEN-C/EBPα-CTNNA1 axis controls myeloid development and transformation
Authors: Chun-Tang Fu, Kang-Yong Zhu, Jian-Qing Mi, Yuan-Fang Liu, Susan T. Murray, Yan-Fang Fu, Chun-Guang Ren, Zhi-Wei Dong, Yi-Jie Liu, Mei Dong, Yi Jin, Yi Chen, Min Deng, Wu Zhang, Bin Chen, Peter Breslin, Sai-Juan Chen, Zhu Chen, Michael W. Becker, Jiang Zhu, Ji-Wang Zhang, Ting Xi Liu
Journal: Blood (2010)
Commentary: Controversies in SIGN guidance on pain control in patients with cancer
Authors: J R Ross, J Riley
Journal: BMJ (2008)

Most patients with cancer experience pain. The ambitious task of the Scottish Intercollegiate Guidelines Network (SIGN) when producing its guidelines on pain control in patients with cancer was to achieve a single set of evidence based recommendations for professionals delivering generic palliative care and for those in specialist palliative care units, across both the acute and community settings. Management of complex pain requires good assessment, good communication, attention to spirituality and psychological issues, and detailed knowledge of analgesics. As such, this comprehensive, well researched guidance from SIGN will be an important resource.1

The availability and delivery of different opioids for breakthrough pain has greatly increased recently, particularly for new rapid onset opioids. Misuse of opioids poses serious risks to patients, clinicians, and society as a whole. Drug exposure in itself is not sufficient to cause a substance related disorder, but a fast acting opioid …
Doctor's suicide prompts look at hours
Authors: C Essex
Journal: BMJ (1994)

A coroner has recommended a review of the working conditions of all house surgeons in New Zealand after finding that 24 year old Dr Mathew Rowbotham, a first year doctor, committed suicide in April. Whangarei Hospital confirmed after the inquest that Dr Rowbotham had worked 80 hours in the week before his death. The doctor's father, Mr Tom Rowbotham, confirmed that his son had worked such long hours every third week that he was on duty.

Dr Loek Henneveld, the chief medical adviser to Northland Health, the crown health enterprise responsible for Whangarei Hospital, said that a continuing review of the working conditions and hours of junior doctors at the hospital had been brought into sharper focus …
Impact of Expanded HIV Screening
Authors: David Lander
Journal: Annals of Internal Medicine (2007)

Letters17 July 2007Impact of Expanded HIV ScreeningDavid Lander, MDDavid Lander, MDFrom the Virginia College of Osteopathic Medicine, Blacksburg, VA 24060.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-147-2-200707170-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Paltiel and colleagues (1) made another useful contribution to the debate of HIV screening. I find it hard to imagine that we will not expand the scope of HIV testing in the future, in a variety of settings, and I support the general concept.The advantages of rapid tests (“higher levels of test acceptance, follow-up, and linkage to care”) seem appealing, but the authors caution that “rapid testing may exacerbate the distress associated with false-positive results.” How often would false-positive results occur?Using the high end of 1% HIV prevalence used in their analysis (“that reflects pre–September ...References1. Paltiel AD, Walensky RP, Schackman BR, Seage GR, Mercincavage LM, Weinstein MC, et al. Expanded HIV screening in the United States: effect on clinical outcomes, HIV transmission, and costs. Ann Intern Med. 2006;145:797-806. [PMID: 17146064] LinkGoogle Scholar2. Kleinman S, Busch MP, Hall L, Thomson R, Glynn S, Gallahan D, et al. False-positive HIV-1 test results in a low-risk screening setting of voluntary blood donation. Retrovirus Epidemiology Donor Study. JAMA. 1998;280:1080-5. [PMID: 9757856] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From the Virginia College of Osteopathic Medicine, Blacksburg, VA 24060.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoExpanded HIV Screening in the United States: Effect on Clinical Outcomes, HIV Transmission, and Costs A. David Paltiel , Rochelle P. Walensky , Bruce R. Schackman , George R. Seage III , Lauren M. Mercincavage , Milton C. Weinstein , and Kenneth A. Freedberg Impact of Expanded HIV Screening Hartmut B. Krentz and M. John Gill Impact of Expanded HIV Screening A. David Paltiel , Rochelle P. Walensky , and Kenneth A. Freedberg Metrics 17 July 2007Volume 147, Issue 2Page: 145-146KeywordsBlood donorsConflicts of interestForecastingHIVPolymerase chain reactionRNA polymeraseScreening guidelinesWestern blot ePublished: 17 July 2007 Issue Published: 17 July 2007 Copyright & PermissionsCopyright © 2007 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Characterization of a transthyretin (prealbumin) variant associated with familial amyloidotic polyneuropathy type II (Indiana/Swiss).
Authors: F E Dwulet, M D Benson
Journal: Journal of Clinical Investigation (1986)

Amyloid fibrils were isolated from cardiac tissue of two brothers who died from familial amyloidotic polyneuropathy (FAP) type II. Sequence analysis on peptides derived from proteolytic cleavage with trypsin and fragmentation with cyanogen bromide reveal that the fibril subunit protein is derived from plasma transthyretin (prealbumin). About two-thirds of the fibril subunit protein was found to contain an amino acid substitution at position 84 where the normal isoleucine residue has been replaced by serine. Sequence analysis of the plasma transthyretin (prealbumin) from the two brothers as well as two clinically diagnosed FAP type II family members and two of four children of affected individuals showed the presence of serine at position 84. The presence of this substitution also correlates with low serum levels of retinol-binding protein and thus transthyretin (prealbumin) position 84 may be involved with the interaction of these two proteins.
Mechanisms and time course of impaired skeletal muscle glucose transport activity in streptozocin diabetic rats.
Authors: R Napoli, M F Hirshman, E S Horton
Journal: Journal of Clinical Investigation (1995)

Skeletal muscle glucose transport is altered in diabetes in humans, as well as in rats. To investigate the mechanisms of this abnormality, we measured glucose transport Vmax, the total transporter number, their average intrinsic activity, GLUT4 and GLUT1 contents in skeletal muscle plasma membrane vesicles from basal or insulin-stimulated streptozocin diabetic rats with different duration of diabetes, treated or not with phlorizin. The glucose transport Vmax progressively decreased with the duration of diabetes. In the basal state, this decrease was primarily associated with the reduction of transporter intrinsic activity, which appeared earlier than any change in transporter number or GLUT4 and GLUT1 content. In the insulin-stimulated state, the decrease of transport was mainly associated with severe defects in transporter translocation. Phlorizin treatment partially increased the insulin-stimulated glucose transport by improving the transporter translocation defects. In conclusion, in streptozocin diabetes (a) reduction of intrinsic activity plays a major and early role in the impairment of basal glucose transport; (b) a defect in transporter translocation is the mechanism responsible for the decrease in insulin-stimulated glucose transport; and (c) hyperglycemia per se affects the insulin-stimulated glucose transport by altering the transporter translocation.
INTOXICATION PROCEEDING FROM THE INTESTINE, ESPECIALLY POLYNEURITIS
Authors: CARL VON NOORDEN
Journal: JAMA (1913)

There is scarcely another term in medicine so frequently misused as the word "auto-intoxication." This word has an unpleasant sound in scientific literature. The attempt has been made to explain with it many pathologic conditions when other explanations were lacking, or when insufficient investigations needed to be supplemented by a fine-sounding word. If we review the history of the term "auto-intoxication" we must distinguish in it several phases. The word was first applied to those well-known conditions which occur in the final stages of severe diabetes mellitus, and further in uremia and cholemia. In these and similar conditions the word retained its original meaning, and no one doubts that in these cases well-characterized forms of auto-intoxication are involved. Then came the well-known work by Bouchard, who extended the conception in an interesting way and explained almost all pathologic conditions which were not caused by microbes as autointoxication. The methods which Bouchard introduced for the support of his views have fallen into discredit. Scarcely a single stone of his structure remains. Indeed, it may be said that the fear of making the same mistake as Bouchard has been a hindrance to the further development of the theory of auto-intoxication. We cannot blame Bouchard, however, for, at the time when he wrote his book on auto-intoxication, chemical and biologic methods were not yet sufficiently developed to guard him against incorrect experiments and conclusions.
Prognosis, Survival, and the Expenditure of Hospital Resources for Patients in an Intensive-Care Unit
Authors: Allan S. Detsky, Steven C. Stricker, Albert G. Mulley, George E. Thibault
Journal: New England Journal of Medicine (1981)

Abstract To define more precisely the factors determining the allocation of resources to critically ill patients, we asked physicians to estimate at the time of admission the short-term prognosis of patients who accounted for 1831 admissions to a medical intensive-care and coronary-care unit. We then examined the relations between this prognosis, the actual outcome, and the resource expenditure during a single hospitalization. We found that the care of nonsurvivors involved a significantly higher mean expenditure than did the care of survivors (P<0.01). Among nonsurvivors, expenditure positively correlated with the probability of survival estimated at the time of admission (P<0.001). Among survivors, expenditure negatively correlated with the probability of survival (P<0.001). Among both nonsurvivors and survivors, total expenditure and expenditure per day were greatest for patients whose outcome were most unexpected. We conclude that prognostic uncertainty is important in determining resource expenditures for the critically ill. This factor warrants greater consideration in future studies of expenditure for the care of catastrophically ill patients. (N Engl J Med. 1981; 305:667–72.)
Delay in labour.
Authors: D D Mathews
Journal: BMJ (1972)

s article (p. 163) on the graphic presentation of the progress of labour, I wondered if any of your readers would be interested in the simple tabular guide to when to start worrying about the duration of labour that I use in teaching the pupil midwives here.It is based on the times to send for medical aid in the second stage that every pupil midwife knows and works in multiples of two and four.
The City of New Orleans, and the Mississippi River. Lake Pontchartrain in the Distance
Authors: Robert M. Golub
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Therapeutic Angiogenesis for Coronary Artery Disease
Authors: Saul Benedict Freedman, Jeffrey M. Isner
Journal: Annals of Internal Medicine (2002)

A large body of evidence in animal models of ischemia shows that administration of angiogenic growth factors, either as recombinant protein or by gene transfer, can augment nutrient perfusion through neovascularization. Many cytokines have angiogenic activity; those that have been best studied in animal models and clinical trials are vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF). Clinical trials of therapeutic angiogenesis in patients with end-stage coronary artery disease have shown increases in exercise time and reductions in anginal symptoms and have provided objective evidence of improved perfusion and left ventricular function. Larger-scale placebo-controlled trials have been limited to intracoronary and intravenous administration of recombinant protein and have not yet shown significant improvement in exercise time or angina compared with placebo. Larger-scale placebo-controlled studies of gene transfer are in progress. Clinical studies are required to determine the optimal dose, formulation, route of administration, and combinations of growth factors and the utility of adjunctive endothelial progenitor-cell or stem-cell supplementation, to provide safe and effective therapeutic myocardial angiogenesis. Determination of which growth factors or cells are required to optimize therapeutic neovascularization in an individual patient should be a goal of future research.
Treatment of behçet's disease with granulocyte and monocyte adsorption apheresis
Authors: Takuro Kanekura, Akira Gushi, Masahiro Iwata, Seita Fukumaru, Ryoko Sakamoto, Koichi Kawahara, Ikuro Maruyama, Tamotsu Kanzaki
Journal: Journal of the American Academy of Dermatology (2004)
Implications of new data on lead toxicity for managing and preventing exposure.
Authors: E K Silbergeld
Journal: Environmental Health Perspectives (1990)

Recent advances in research on low-level lead poisoning point to the need to increase efforts to prevent exposure. Current biomedical consensus accepts that blood lead levels as low as 5 to 15 mcg/dL are risky to fetuses, young children, and adults. Lead at low dose is associated with increased blood pressure in adults, and chronic exposure has been associated in cohort studies with kidney disease and cancer. Data on lead toxicokinetics also points to the hazards of low-level, chronic exposure, since the lead that is accumulated over time in bone can be released at a relatively rapid rate during pregnancy and menopause. Sources that contribute to current lead exposure of the general population include unabated lead-based paint and contaminated soils, as well as lower level but pervasive sources in drinking water, food, and consumer products.
Abstract 1141: p53-dependent regulation of epithelial-to-mescenchymal transition by nf-κb in head and neck squamous cell carcinoma
Authors: Yuan Lin, Jie Luo, Elliot Abemayor, Sherven Sharma, Steven Dubinett, Maie S. John
Journal: Cancer Research (2014)

Abstract PURPOSE: In head and neck squamous cell carcinoma (HNSCC), mutations of p53 usually coexist with aberrant activation of NF-kappaB (NF-κB) and other transcription factors which promote tumor pathogenesis. However, how these factors mediate oncogenesis and metastasis is not fully understood. Herein we investigate the mechanisms by which p53 and NF-κB contribute to Epithelial-Mesenchymal Transition (EMT) in HNSCC. EXPERIMENTAL DESIGN: We evaluated the effects of p65 mutation on the molecular events of EMT in surgical specimens and HNSCC cell lines. We examined the correlation with tumor histologic features. RESULTS: In HNSCC cell lines with mutant p53, p65 knockdown promotes EMT. In contrast, in normal oral epithelial cells or HNSCC cells with WT p53, p65 over-expression, instead of knockdown, promotes EMT. Ablation of p53 in normal oral epithelial cells blocks p65 induced EMT. These findings are functionally corroborated herein in three-dimensional cell culture, anchorage-independent growth assays, and tumor cell migration assays. CONCLUSIONS: This is the first report indicating the role of p53 status in the NF-κB -induced promotion of EMT in HNSCC. Bortezomib-based regimens have been shown to have minimal activity in recurrent or metastatic head and neck cancer. Our new findings are important in understanding a possible basis for these clinical findings as well as defining important implications for targeted chemoprevention and therapy. Citation Format: Yuan Lin, Jie Luo, Elliot Abemayor, Sherven Sharma, Steven Dubinett, Maie St John. p53-dependent regulation of epithelial-to-mescenchymal transition by nf-κb in head and neck squamous cell carcinoma. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1141. doi:10.1158/1538-7445.AM2014-1141
<i>BMJ</i> statistical errors
Authors: Tim J Cole, Douglas Altman, Deborah Ashby, Mike Campbell, Jonathan Deeks, Stephen Evans, Hazel Inskip, Julie Morris, Gordon Murray
Journal: BMJ (2004)

Competing interests: At the time of the study, AMB was chairman of the Committee on Safety of Medicines and now is chairman of the MHRA.MP is a member of the Committee on Safety of Medicines and of the subcommittee on pharmacovigilance.