tbuckley/cabot-search huggingface dataset:
The Frequency and Suppressor Function of CD4+CD25highFoxp3+ T Cells in the Circulation of Patients with Squamous Cell Carcinoma of the Head and Neck
Authors: Laura Strauss, Christoph Bergmann, William Gooding, Jonas T. Johnson, Theresa L. Whiteside
Journal: Clinical Cancer Research (2007)

Abstract Objective: Immune escape is a characteristic feature of head and neck squamous cell carcinoma (HNSCC). Regulatory T cells (Treg) might contribute to HNSCC progression by suppressing antitumor immunity, and their attributes in patients are of special interest. Methods: Multicolor flow cytometry was used to study the frequency and phenotype of Treg in peripheral blood lymphocytes of 35 patients with HNSCC and 15 normal controls (NC). CD4+CD25high T cells were purified by fluorescence-activated cell sorting and tested for regulatory function by coculture with carboxyfluorescein diacetate succinimidylester–labeled autologous CD4+CD25− responder cells. Results: The percentages of circulating CD4+CD25+ T cells were increased in HNSCC patients (5 ± 3%) versus NC (2 ± 1.5%). In patients, this cell subset largely contained CD4+CD25highFoxp3+ T cells and only few CD25low/interm cells. In addition, the frequency of Treg positive for CD62L, CTLA-4, Fas, FasL, and Foxp3 was greater in the circulation of patients than in NC (P &amp;lt; 0.0001). In HNSCC patients, Treg mediated significantly higher suppression (78 ± 7%) compared with Treg in NC (12 ± 4%) with P &amp;lt; 0.0001. Surprisingly, higher Treg frequency (P &amp;lt; 0.0059) and levels of suppression (P &amp;lt; 0.0001) were observed in patients with no evident disease (NED) than in untreated patients with active disease (AD). Conclusions: The frequency of T cells with suppressor phenotype and function (Treg) was significantly greater in HNSCC patients who were NED after oncologic therapy relative to those with AD. This finding suggests that oncologic therapy favors expansion of Treg.
Insect-bite-like Wells’ syndrome in association with mantle-zone lymphoma
Authors: T. Zeeli, M. Feinmesser, R. Segal, M. David
Journal: British Journal of Dermatology (2006)

Journal Article Insect‐bite‐like Wells' syndrome in association with mantle‐zone lymphoma Get access T. Zeeli, T. Zeeli Departments of Dermatology and Pathology, Rabin Medical Center, Beilinson Campus, Petah Tiqwa 49100, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel T. Zeeli. E‐mail: talzl@clalit.org.il Search for other works by this author on: Oxford Academic Google Scholar M. Feinmesser, M. Feinmesser Departments of Dermatology and Pathology, Rabin Medical Center, Beilinson Campus, Petah Tiqwa 49100, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel Search for other works by this author on: Oxford Academic Google Scholar R. Segal, R. Segal Departments of Dermatology and Pathology, Rabin Medical Center, Beilinson Campus, Petah Tiqwa 49100, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel Search for other works by this author on: Oxford Academic Google Scholar M. David M. David Departments of Dermatology and Pathology, Rabin Medical Center, Beilinson Campus, Petah Tiqwa 49100, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 155, Issue 3, 1 September 2006, Pages 614–616, https://doi.org/10.1111/j.1365-2133.2006.07345.x Published: 01 September 2006 Article history Accepted: 12 January 2006 Published: 01 September 2006
Effects of diltiazem on regional coronary hemodynamics during atrial pacing in patients with stable exertional angina: implications for mechanism of action.
Authors: S De Servi, M Ferrario, S Ghio, A Bartoli, A Mussini, E Poma, L Angoli, E Bramucci, E Aimè, R Rondanelli
Journal: Circulation (1986)

To investigate the mechanism of the antianginal action of diltiazem in stress-induced myocardial ischemia, we studied 12 patients with stable exertional angina and disease of the proximal left anterior descending artery by measuring great cardiac vein flow (GVCF) and calculating anterior regional coronary resistance (ARCR) during myocardial ischemia induced by atrial pacing before and after intravenous administration of diltiazem (0.25 mg/kg in a bolus dose followed by continuous infusion of 0.005 mg/kg/min). Diltiazem increased the pacing time to angina from 6.9 +/- 3.5 to 10.7 +/- 4 min (p less than .001). At peak pacing heart rate was increased after diltiazem (from 128 +/- 17 to 145 +/- 17 beats/min, p less than .005), while mean arterial pressure was decreased (from 131 +/- 19 to 113 +/- 17 mm Hg, p less than .025), leaving the double product unaltered. At peak pacing no changes were observed in GCVF (from 115 +/- 46 to 119 +/- 46 ml/min, p = NS), ARCR (from 1.3 +/- 0.4 to 1.1 +/- 0.4 mm Hg/ml/min), or myocardial oxygen consumption of the anterior region (from 14.5 +/- 4.2 to 13.4 +/- 4.7 ml/min). Reduction of myocardial oxygen demand plays a major role in the antianginal action of diltiazem in patients with stress-induced myocardial ischemia.
More cancer patients in England are getting approved drugs
Authors: Susan Mayor
Journal: BMJ (2006)

The percentage of patients with cancer in England who are being treated with drugs approved for use in the NHS is growing, says a report published this week. And although regional variations in access to drugs remain, these are falling.

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The report, from Mike Richards, England's national cancer director, showed an average increase of 47% in the use of cancer drugs approved by the National Institute for Health and Clinical Excellence (NICE), the body that regulates drug use by the NHS, during the first six months of 2005, in comparison with a previous review that was based …

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Mental health care in the district hospital.
Authors: H G Egdell
Journal: BMJ (1984)

Description d'un programme d'installation de consultations psychiatriques dans les hopitaux et services de medecine courante dans le Tiers Monde (Ouganda): organisation d'un service d'urgences, diagnostic des maladies organiques et fonctionnelles, traitement des malades atteints de nevrose, attitudes vis-a-vis de la sante mentale, problemes de l'enfance, stages de formation
Satire
Authors: Theodore Kamholtz
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Quality of Life Gets Equal Consideration as a Clinical Trial End Point
Authors: C. Vanchieri
Journal: JNCI Journal of the National Cancer Institute (1990)

Journal Article Quality of Life Gets Equal Consideration as a Clinical Trial End Point Get access Cori Vanchieri Cori Vanchieri Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 82, Issue 3, 7 February 1990, Pages 173–174, https://doi.org/10.1093/jnci/82.3.173 Published: 07 February 1990
A Case of Perineal Section—Foreign Body Found in the Urethra.
Authors: W. J. Welsh
Journal: JAMA (1892)

To the Editor of the Journal of the American Medical Association: The following case may present some unusual points of interest: I was consulted at different times by T. S., aged 55 years, a practitioner of medicine,<i>not</i>of the regular school of practice, in regard to a bladder trouble. He had frequent urination, and a constant discharge of pus. He stated that he had been shot by a pistol-ball through the scrotum during the late war. He said he thought he had stone in the bladder, or that the pistol-ball had lodged in or near the bladder. That he could not stand horse-back riding; had frequent perineal abscesses; was confined to his bed for days at a time occasionally. He was in bad health, and his general appearance indicated a urinary trouble. His urine had a horribly ammoniacal odor. I advised perineal section, and he consented. On March 17,
Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor
Authors: Scott R. Daigle, Edward J. Olhava, Carly A. Therkelsen, Christina R. Majer, Christopher J. Sneeringer, Jeffrey Song, L. Danielle Johnston, Margaret Porter Scott, Jesse J. Smith, Yonghong Xiao, Lei Jin, Kevin W. Kuntz, Richard Chesworth, Mikel P. Moyer, Kathrin M. Bernt, Jen-Chieh Tseng, Andrew L. Kung, Scott A. Armstrong, Robert A. Copeland, Victoria M. Richon, Roy M. Pollock
Journal: Cancer Cell (2011)
Isidor ("Okkie") Gordon John Simpson Noble Harry Pandov Stanley Rivlin Judith Sarah Thomas (nee Avery) Clifford Grant Tulloh Richard George ("Dickie") Vine William Walker Arthur Watts
Authors: Y K Seedat, J. Walton, A. Bold, A. Rivlin, H. d. l. H. Davies, I. F Wall, C I Phillips, R J Vine, J. Walker, M. F Williams
Journal: BMJ (1998)
Polarizing the T helper 17 response in<i>Citrobacter rodentium</i>infection via expression of resistin-like molecule α
Authors: Gang Chen, Alexander J Chan, Josiah I Chung, Jessica C Jang, Lisa C Osborne, Meera G Nair
Journal: Gut Microbes (2014)

Citrobacter rodentium infection is a murine model of pathogenic Escherichia coli infection that allows investigation of the cellular and molecular mechanisms involved in host-protective immunity and bacterial-induced intestinal inflammation. We recently demonstrated that following C. rodentium infection, the absence of Resistin-Like Molecule (RELM) α resulted in attenuated Th17 cell responses and reduced intestinal inflammation with minimal effects on bacterial clearance. In this addendum, we investigated the cytokine modulatory effects of RELMα and RELMα expression in the intestinal mucosa following C. rodentium infection. We show that in addition to promoting Th17 cytokine responses, RELMα inhibits Th2 cytokine expression and Th2-cytokine effector macrophage responses in the C. rodentium-infected colons. Second, utilizing reporter C. rodentium, we examined RELMα expression and macrophage recruitment at the host pathogen interface. We observed infection-induced macrophage infiltration and RELMα expression by intestinal epithelial cells. The influence of infection-induced RELMα on macrophage recruitment in the intestine is discussed.
Electrophysiology and Arrhythmogenic Activity of Single Cardiomyocytes From Canine Superior Vena Cava
Authors: Yi-Jen Chen, Yao-Chang Chen, Hung-I Yeh, Cheng-I Lin, Shih-Ann Chen
Journal: Circulation (2002)

Background — The superior vena cava (SVC) has been proved to be a focal point in the initiation of paroxysmal atrial fibrillation. The autonomic nervous system plays an important role in the genesis of atrial fibrillation. However, the arrhythmogenic potentials of SVC and its responses to autonomic agents are not clear. The purpose of this study was to isolate single SVC cardiomyocytes and to investigate their electrophysiological characteristics, as well as the direct effects of autonomic agents. Methods and Results — Canine SVC cardiomyocytes were isolated by perfusion with digestive enzymes. The action potentials and ionic currents were investigated in single SVC cardiomyocytes using the whole-cell clamp technique. Dissociation of the SVC yielded rod-shaped single cardiomyocytes with (n=74, 51%) or without (n=71, 49%) pacemaker activities. There were similar densities of inward Ca 2+ , delayed rectifier K + , transient inward, inward rectifier K + , and pacemaker currents between SVC cardiomyocytes with and without pacemaker activity. SVC cardiomyocytes with pacemaker activity have, however, greater transient outward currents than those without pacemaker activity. In SVC cardiomyocytes, acetylcholine (5.5 μmol/L) abolished the spontaneous activities, but isoproterenol (10 nmol/L), atropine (10 μmol/L), and phenylephrine (10 μmol/L) accelerated the spontaneous activity and induced the occurrences of early or delayed afterdepolarizations. Conclusions — These findings suggest that SVC cardiomyocytes have distinct action potentials and ionic current profiles that may be responsible for the arrhythmogenic activity of the SVC.
Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2
Authors: Yasuhiro Maejima, Shiori Kyoi, Peiyong Zhai, Tong Liu, Hong Li, Andreas Ivessa, Sebastiano Sciarretta, Dominic P Del Re, Daniela K Zablocki, Chiao-Po Hsu, Dae-Sik Lim, Mitsuaki Isobe, Junichi Sadoshima
Journal: Nature Medicine (2013)
Comparison of acute cardiovascular effects and oxygen-supply following haemodilution with dextran, stroma-free haemoglobin solution and fluorocarbon suspension
Authors: G. P BIRO
Journal: Cardiovascular Research (1982)

Changes in haemodynamics and myocardial oxygen-supply were investigated in anaesthetised dogs, when the haematocrit was reduced to 18 to 22% by isovolaemic haemodilution with 8% stroma-free haemoglobin solution, 20% Fluosol-DA‡ and 6% dextran 70. Comparable haemodilution and comparable reduction in whole-blood viscosity was not followed by similar changes in cardiac output: dextran- and Fluosol-diluted dogs showed significantly elevated cardiac output, while haemoglobin-diluted dogs failed to do so. As a result, systemic O2-transport was better maintained with dextran and Fluosol. Myocardial blood flow, estimated by 15 μm microspheres, increased in all three haemodiluted groups, but oxygen-supply was not similar. The haemoglobin-diluted dogs showed inadequate O2-supply, suggested by a fall of coronary sinus pO2; dextran-diluted dogs exhibited adequate O2-supply suggested by maintained coronary sinus pO2, while the Fluosol-diluted group enjoyed excessive O2-supply, indicated by a markedly elevated pO2 in coronary sinus blood. The observations suggest that similar degrees of haemodilution may not be followed by comparable changes in haemodynamics and O2-supply, depending on O2-unloading characteristics.
Cost-effectiveness and Resource Allocation
Authors: Joshua P. Cohen
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Does vessel size have an impact on recurence rates following gamma vascular brachytherapy: acute and nine-month results from SCRIPPS III registry
Authors: Milena G. Adamian, Roxana Mehran, George Dangas, Gishel New, Andrea S. Abizaid, Alexandra J. Lansky, Giora Weisz, Mark A. Grise, Michael B. Collins, Edward M. Kreps, Gregg W. Stone, Issam Moussa, Jeffrey W. Moses, Martin B. Leon, Paul S. Teirstein
Journal: Journal of the American College of Cardiology (2002)
Renal Tubular Dysfunction in Minamata Disease
Authors: KENJI IESATO
Journal: Annals of Internal Medicine (1977)

"Minamata disease" was found among the residents along Minamata bay contaminated with the effluent from an industrial plant using mercury. The patients were suffering from various neurologic disorders primarily due to organic mercury poisoning. Evidence is described of renal tubular dysfunction associated with this disease by the immunochemical demonstration or renal tubular epithelial antigen and beta-2-microglobulin in the urine. Nineteen patients with Minamata disease and 35 diseased and healthy control subjects were examined. The contents of urinary renal tubular epithelial antigen and beta-2-microglobulin, and the ratios of these proteins to albumin in individuals with Minamata disease were significantly different from the levels in healthy control subjects (P less than 0.05) were identical to those found in patients with tubular and the values, proteinuria. These results indicate that Minamata disease is associated with renal tubular dysfunction, and also suggest that these procedures would be useful for screening the nephrotoxicity in the environmental exposure of heavy metals.
Gold in Arthritis
Authors: Lonnie B. Hanauer
Journal: JAMA (1974)

<h3>To the Editor.—</h3> The<i>Primer on the Rheumatic Diseases</i>(<b>224</b>[suppl]:661-812, 1973) is, with justification, recommended to medical students, house staff, and practitioners as the best concise summary of rheumatic diseases. We are disturbed, therefore, to find a statement on page 733 relating to the therapy of psoriatic arthritis to the effect that "chrysotherapy... [is] not helpful and may aggravate the skin disease." This advice is not justified by clinical studies and may result in the withholding of gold from patients who would benefit from it. Six of the seven references in the<i>Primer</i>do not mention gold therapy. The seventh (Wright V: Psoriatic arthritis.<i>Bull Rheum Dis</i>21:627, 1971) notes that "gold is not contraindicated as it has been found that no more skin reactions are experienced in psoriasis than... in rheumatoid arthritis." Three leading rheumatology tests (Hollander-McCarty, Copeman, and Boyle-Buchanan) all deny any increased incidence of skin reactions although
Cellular retinol-binding protein-1 in hepatocellular carcinoma correlates with β-catenin, Ki-67 index, and patient survival
Authors: Annette Schmitt-Gräff, Viktoria Ertelt, Hans P. Allgaier, Konrad Koelble, Manfred Olschewski, Roland Nitschke, Marie L. Bochaton-Piallat, Giulio Gabbiani, Hubert E. Blum
Journal: Hepatology (2003)

The cellular retinol–binding protein–1 (CRBP–1) plays a key role in the esterification and intercellular transfer of retinol. By in situ hybridization, immunohistochemistry, and confocal laser scanning microscopy (CLSM), we show that, in normal liver, CRBP–1 is strongly expressed in the cytoplasm of hepatic stellate cells (HSCs) and myofibroblasts (MFs) with only low CRBP–1 levels in hepatocytes. By contrast, in 196 hepatocellular carcinoma (HCC) specimens CRBP–1 expression in MFs was down–regulated in 83%. Patients with high CRBP–1 expression in MFs had a significantly higher 2–year survival as compared with patients with low CRBP–1 expression (52% vs. 29%, respectively; P = .034). An aberrant nuclear CRBP–1 accumulation resulting from cytoplasmic invagination was found in 29% of HCCs. Nuclear CRBP–1 staining correlated positively with a favorable tumor stage (Okuda stage I; P = .01) and negatively with the Ki–67 + proliferation fraction (PF). A Ki–67 + PF of ≥10% was associated with a lower 2–year survival probability as compared with patients with a Ki–67 + PF of &lt;10% (12% vs. 40%, respectively; P = .015). Prognosis did not correlate with the nuclear β–catenin expression. There was, however, a close correlation between nuclear CRBP–1 inclusions and nuclear β–catenin staining in HCCs ( P = .008), suggesting a cross talk between CRBP–1 and the Wnt/wingless signal transduction pathway. In conclusion, our findings demonstrate that CRBP–1 detection may be useful for the discrimination between nonneoplastic and neoplastic liver cells and suggest that modulation of CRBP–1 expression in HCCs contributes to tumor growth and progression via retinoid–mediated signaling and disruption of cellular vitamin A homeostasis.
Caesarean section rate in England reaches 22%
Authors: S. Mayor
Journal: BMJ (2002)

More than a fifth of babies in England are delivered by caesarean section, latest hospital statistics for 2000-1 show. The rate increased from 18% in 1997-8 to 22% in 2000-01

Over half of the total of 560 000 hospital deliveries in the analysis were spontaneous, both in onset and delivery. However, 21% of deliveries were induced, and 14% of women had an episiotomy. Just over 11% of deliveries were instrumental, with …
Bartenders' Pulmonary Function After Establishment of a Smoke-Free Workplace
Authors: Chaim Bell, David Urbach
Journal: JAMA (1999)

To the Editor: The results of the study by Dr Eisner and colleagues 1 addressing the effects of workplace environmental tobacco smoke (ETS) exposure on respiratory symptoms and lung function show a change in both respiratory symptoms and measures of spirometric assessment. Among all study participants, they detected a change in mean forced expiratory volume in 1 second (FEV1) of 0.039 L (95% confidence interval [CI], ˛0.030 to 0.107 L), which was not statistically significant. When the subgroup with complete cessation of workplace ETS was analyzed, a greater and statistically significant increase in FEV1 of 0.142 L (95% CI, 0.020-0.264 L) was noted. While these findings contribute to the authors’ claim of an improvement in lung function after cessation of heavy ETS exposure, the link between statistically significant differences in lung function improvement and its clinical importance may not be that clear. Indeed, in a study of more than 100 patients with chronic obstructive lung disease and a mean FEV1 of 0.975 L, an increase of 0.112 L or 4% of predicted lung function was thought by the majority of patients to represent the minimum clinically noticeable difference. 2 The individuals studied by Eisner et al had a far greater baseline mean FEV1 (3.38 L vs 0.975 L), a far smaller change in the percent of predicted lung function (88.9% to 88.2% [0.7% vs 4% in the study by Redelmeier et al 2 ]), and a far smaller absolute change in FEV1 (0.039 L vs 0.112 L). Therefore, the comparatively small increase in FEV1 found in this study may not represent a clinically important change. Cessation of ETS exposure in the workplace may provide improvements in subjective symptom scores and statistically significant gains in lung function. However, the data provided by Eisner et al do not seem to support a corresponding clinically important gain in lung function.