Immunologic Memory of the Normal and the Leukemic Lymphocyte
Authors: JEROME I. BRODY
Journal: Annals of Internal Medicine (1967)

Article1 September 1967Immunologic Memory of the Normal and the Leukemic LymphocyteJEROME I. BRODY, M.D., F.A.C.P., FRANK OSKI, M.D.JEROME I. BRODY, M.D., F.A.C.P.Search for more papers by this author, FRANK OSKI, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-3-573 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe purpose of this study was to determine whether the immune indolence of the leukemic lymphocyte is complete or whether its failure to respond to stimuli is selective and depends upon the nature of the antigen to which the lymphocyte's host organism is exposed. Although the diminished in vivo and in vitro responses of the neoplastic lymphocyte to immunogenic and metabolic stimulants are acknowledged, the limits of this hyporeactivity and the extent of lymphocytic immunologic recall remain undefined. There is no established experimental evidence to support the concept that the leukemic lymphocyte's failure to synthesize in vivo antibody to one...References1. BRODYBEIZER JIL: Immunologic incompetence of the neoplastic lymphocyte in chronic lymphocytic leukemia. Ann. Intern. Med. 64: 1237, 1966. LinkGoogle Scholar2. BERNARDGERALDESBOIRON CAM: Effects of phytohaemagglutinin on blood-cultures of chronic lymphocytic leukaemias. Lancet 1: 667, 1964. CrossrefMedlineGoogle Scholar3. FURTHSCHUITHIJMANS RVHRW: The formation of immunoglobulins by human tissues in vitro. IV. Circulating lymphocytes in normal and pathological conditions. Immunology 11: 29, 1966. MedlineGoogle Scholar4. MILLER JF: Immunity in the foetus and the newborn. Brit. Med. Bull. 22: 21, 1966. CrossrefMedlineGoogle Scholar5. KALSERCOHENARTEAGAMAYORALHOFFERTFRAZIER MHRILWRD: Normal viral and bacterial flora of the human small and large intestine. New Eng. J. Med. 274: 500, 1966. CrossrefMedlineGoogle Scholar6. 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To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JEROME I. BRODY, M.D., F.A.C.P.; FRANK OSKI, M.D.Affiliations: Philadelphia, PennsylvaniaFrom the Department of Medicine, the Graduate Hospital of the University of Pennsylvania, the Department of Pediatrics, the Hospital of the University of Pennsylvania, and the University of Pennsylvania School of Medicine, Philadelphia, Pa.This study was supported by research grants CA-07000-05 and HE-01919 and training grant 5 T1 CA-5159-03, U. S. Public Health Service, Washington, D. C.Dr. Brody is the recipient of career development ward 1-K3-CA 8371, U. S. Public Health Service.Requests for reprints should be addressed to Jerome I. Brody, M.D., Department of Medicine, Graduate Hospital of the University of Pennsylvania, Philadelphia, Pa. 19146. 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