tbuckley/cabot-search huggingface dataset:
Intense F-18 FDG Uptake in the Stomach Wall in Follicular Gastritis in Zollinger-Ellison Syndrome
Authors: Sandip Basu, Narendra Nair
Journal: Clinical Nuclear Medicine (2007)

A 59-year-old woman, who had surgery for a suspected pancreatic tumor and was detected to have a gastrinoma, was referred for F-18 FDG PET for disease evaluation. Whole-body FDG PET showed diffuse intense FDG PET uptake (SUVmax 5.44) throughout the stomach. The patient was asked to drink a large amount of water and a repeat spot FDG PET (limited to the surface marking of the stomach) was acquired. The uptake was mildly reduced (SUVmax 4.75) but persisted in the distended stomach wall. An endoscopic biopsy from the antrum and fundus revealed follicular gastritis with erosion. The biopsy was negative for neoplasm. The patient was thought to have gastritis in a Zollinger-Ellison syndrome. Varying degrees of FDG uptake in the stomach have been described in certain benign conditions. Gastritis secondary to Zollinger-Ellison syndrome should be included in the differential diagnosis of diffuse intense gastric uptake, when such a history is present in the patient.
Penetrance of Mutations in Plakophilin-2 Among Families With Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy
Authors: Darshan Dalal, Cynthia James, Rajiv Devanagondi, Crystal Tichnell, April Tucker, Kalpana Prakasa, Philip J. Spevak, David A. Bluemke, Theodore Abraham, Stuart D. Russell, Hugh Calkins, Daniel P. Judge
Journal: Journal of the American College of Cardiology (2006)
A CONSIDERATINOF PSYCHOSOMATIC FACTORS IN THE AETIOLOGY OF SOME SKIN DESEASES
Authors: G. A. HODGSON
Journal: British Journal of Dermatology (1945)

Journal Article A CONSIDERATINOF PSYCHOSOMATIC FACTORS IN THE AETIOLOGY OF SOME SKIN DESEASES Get access G. A. HODGSON, M.A., M.D. Oxon. G. A. HODGSON, M.A., M.D. Oxon. Major, R.A.M.C, Specialist in Dermatology Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 57, Issue 7-8, 1 July 1945, Pages 125–138, https://doi.org/10.1111/j.1365-2133.1945.tb11216.x Published: 01 July 1945
Prolonged hepatomegaly in mice that cannot inactivate bacterial endotoxin
Authors: Baomei Shao, Richard L. Kitchens, Robert S. Munford, Thomas E. Rogers, Don C. Rockey, Alan W. Varley
Journal: Hepatology (2011)

Transient hepatomegaly often accompanies acute bacterial infections. Reversible, dose-dependent hepatomegaly also occurs when animals are given intravenous infusions of bacterial lipopolysaccharide (LPS). We found that recovery from LPS-induced hepatomegaly requires a host enzyme, acyloxyacyl hydrolase (AOAH), that inactivates LPS. When we challenged Aoah(-/-) mice with low doses of LPS or gram-negative bacteria, their livers remained enlarged (as much as 80% above normal) many weeks longer than did the livers of Aoah(+/+) animals. When compared with livers from LPS-primed Aoah(+/+) mice, LPS-primed Aoah(-/-) livers had (1) more numerous and larger Kupffer cells, (2) intrasinusoidal leukocyte aggregates and activated sinusoidal endothelial cells, and (3) sustained production of interleukin (IL)-10 and messenger RNAs (mRNAs) for tumor necrosis factor (TNF), IL-10, and IRAK-M. Depleting Kupffer cells decreased the liver enlargement by ≈40%, whereas depletion of neutrophils, dendritic cells, natural killer (NK) cells, NK-T cells, or B cells had no effect. Pretreatment with dexamethasone almost completely prevented prolonged hepatomegaly in Aoah(-/-) mice, whereas neutralizing TNF or interleukin-1β was only partially effective. In contrast, an antagonistic antibody to the IL-10 receptor increased LPS-induced hepatomegaly by as much as 50%.
Trust in the Medical Literature—and Viewpoints in JAMA Internal Medicine
Authors: Robert Steinbrook, Rita F. Redberg
Journal: JAMA Internal Medicine (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
The calcium ionophore A23187 stimulates glycoprotein secretion by the guinea pig gallbladder
Authors: Peter F. Malet, Catherine L. Locke, Bruce W. Trotman, Roger D. Soloway
Journal: Hepatology (1986)

The purpose of this study was to examine the role of calcium ions in gallbladder glycoprotein secretion in cultured guinea pig gallbladder explants. The calcium ionophore A23187 showed a threshold of 2 μg per ml medium for stimulation of secretion of [ 3 H]glucosamine-labeled glycoproteins over a 30 min incubation period. The ionophore at 3 and 5 μg per ml medium resulted in a 3- to 4-fold increase in secretion of [ 3 H]glucosamine-labeled glycoproteins. Ionophore-induced stimulation of glycoprotein secretion was abolished by the addition of 0.01 m M verapamil to the medium. To study the effect of changes in extracellular calcium on basal glycoprotein secretion, explants were cultured for 24 hr in media with 0.007, 0.5 or 2.0 m M calcium; no differences in basal glycoprotein secretion were observed. When cultured in medium with 1.0 m M EGTA, basal secretion decreased significantly vs. controls in 0.007 m M total calcium medium. Total [ 3 H]glucosamine incorporation by explants in medium with EGTA was unaltered, however, suggesting that the low level of calcium in the medium was selectively impairing the secretory process. These findings indicate that calcium ions are important in the regulation of gallbladder glycoprotein secretion.
Abstract 1691: Niche inflammation strengthens the IGF-1R-Akt signaling and results in poor prognosis of HBV-HCCs
Authors: Hsin-Yi Lin, Te-Sheng Chang, Hsin-Wei Jen, Ya-Ting Yang, Ya-Ping Lin, Kam-Fai Lee, Shui-Yi Tung, Liang-Mou Kuo, Yen-Hua Huang
Journal: Cancer Research (2011)

Abstract Hepatocellular carcinoma (HCC) is the fifth most common cancer in the world. Inflammation of various etiologies has been documented to highly associate with the development of HCC. However, the role of inflammation in virus-induced hepatocarcinogenesis still remains largely unknown. Here we demonstrate that the potential synergistic effect of HBV and proinflammatory cytokines might associate with the poor prognosis of HBV-related HCC (HBV-HCC) via IGF-1R signaling activation. In this study, human HCC frozen tissues and tissue blocks were collected for clinical analysis under IRB approval. Real-time quantitative PCR analysis of HCC frozen tissues revealed a reciprocal correlation between the transcriptional levels of IGF-1R and disease-free interval (DFI) in HBV-HCC tissues (N=117). Immunohistochemical staining of HCC tissue blocks also showed a strong correlation between IGF-1R signaling activation (IGF-1R/phospho-IGF-1R) and short DFI. To test the collaborative effect of HBV and inflammation, human HCC cell lines including HBV-related cells (HepG2.2.15, PLC5, Hep3B, and HA22T) and non-HBV-related cells (HepG2 and Huh 7) were cultivated with inflammation condition medium (inflam-CM). We found that inflam-CM treatment significantly increased the levels of pluripotent regulator IGF-1/IGF-1R and IGF-1R signaling (phospho-IGF-1R and phospho-Akt) in HBV- HCC cells (HepG2.2.15 and Hep3B). Additionally, inflam-CM also markedly increased the drug resistance capacity of HepG2.2.15 and Hep3B cells. Blockage of IGF-1R phosphorylation by picropodophyllin (PPP) or down-regulation of IGF-1R by siRNA dramatically increased the drug sensitivity of HBV-HCC cells. Further analysis using neutralizing antibodies against potential proinflamatory cytokines is ongoing to identify the cross-talk between inflammation and IGF-1R signaling in HBV- HCCs. In summary, our works demonstrate that niche inflammation may activate the IGF-1R-Akt signaling and result in poor prognosis of HBV-HCC. This finding may provide a potential therapeutic target for HBV-HCC. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1691. doi:10.1158/1538-7445.AM2011-1691
Demodicosis and rosacea: Epidemiology and significance in daily dermatologic practice
Authors: Fabienne Forton, Marie-Anne Germaux, Thierry Brasseur, Anne De Liever, Marianne Laporte, Chantal Mathys, Ursula Sass, Jean-Jacques Stene, Sylvie Thibaut, Muriel Tytgat, Bruno Seys
Journal: Journal of the American Academy of Dermatology (2004)
Electropharmacological characterization of cardiac repolarization in German shepherd dogs with an inherited syndrome of sudden death: abnormal response to potassium channel blockers
Authors: Jocelyn Mérot, Vincent Probst, Michèle Debailleul, Uwe Gerlach, N.Sydney Moise, Hervé Le Marec, Flavien Charpentier
Journal: Journal of the American College of Cardiology (2000)
P-Values Exact.
Authors: FRANK JAGDIS
Journal: Annals of Internal Medicine (1986)

Software1 October 1986P-Values Exact.FRANK JAGDIS, M.D.FRANK JAGDIS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-105-4-641_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptP-VALUES EXACT is a program for the statistical analysis of a 2 X 2 contingency table. The program is compiled and runs from DOS. A version is included for computers with the arithmetic coprocessor (8087), which increases the speed of calculations. The source code is available on the program disk; this is of interest to programmers who wish to study the program or modify the code. Modification would be recommended only to experts in the C language. The program presents a screen with eight blank tables for data entry. The observed values are entered into the box and the program... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: FRANK JAGDIS, M.D.Affiliations: Victoria, British Columbia Canada PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1986Volume 105, Issue 4Page: 641-651KeywordsComputers ePublished: 1 December 2008 Issue Published: 1 October 1986 PDF downloadLoading ...
Genetic programs expressed in resting and IL-4 alternatively activated mouse and human macrophages: similarities and differences
Authors: Fernando O. Martinez, Laura Helming, Ronny Milde, Audrey Varin, Barbro N. Melgert, Christina Draijer, Benjamin Thomas, Marco Fabbri, Anjali Crawshaw, Ling Pei Ho, Nick H. Ten Hacken, Viviana Cobos Jiménez, Neeltje A. Kootstra, Jörg Hamann, David R. Greaves, Massimo Locati, Alberto Mantovani, Siamon Gordon
Journal: Blood (2013)
Abstract 4235: Site specific profiling of histone methyltransferases in cancer cells using histone peptide microarray containing a comprehensive set of histone peptides.
Authors: Bing Zhu, Ailing Hong, Chris Hebel, Xiaochuan Zhou, Xiaolian Gao
Journal: Cancer Research (2013)

Abstract Post-translational modifications (PTMs) of histones play a critical role in diverse biological processes including chromatin compaction, gene expression and cell differentiation. Among a myriad of PMTs, histone methylation catalyzed by histone methyltransferases (HMTs) has been increasingly recognized as an important player responsible for a major signaling mechanism in eukaryotic cells. This suite of epigenetic modifiers represents a new and promising class of therapeutic targets. In cancer, there is a growing body of evidence that suggests changes in the activity of HMTs (a class of chromatin-modifying enzymes) contribute to the uncontrolled cell proliferation that is a hallmark of this devastating disease. The sequence specificity of the substrates of HMTs under a cellular condition are largely unknown but known targets have been mostly identified through a conventional candidate-based approach by using purified HMTs. However, such an experiment frequently does not reflect what could be occurring in cellular contexts or in vivo. In this study, we designed and synthesized a comprehensive histone peptide microarray (PepArray) on a microfluidic chip which contains 3,919 peptides. The peptides contain nine residues with the methylation sites and mutant sites situated in the middle of the sequence so that each peptide has a unique possibility for modification such as methylation or acetylation. We obtained nuclear extract from the breast cancer cell line T47D, and applied the protein lysates to the histone methylation PepArray chip. After incubation of the chip with a methyl-specific antibody, significant signals were detected at the sites containing peptides corresponding to H2AK74, H3K122, and H4K59. We found null signal at mutant sites where the target lysine(K) was replaced with alanine(A). These results reveal the specific activity profiles of HMTs at defined histone sites in a cellular system. Planned further investigation will compare the different histone methylation or acetylation profiles in the various cellular systems, especially in different cancer systems. The current experiment demonstrates an effective solution to comprehensive studies of epigenetic modification. This information may be translated into therapeutic targets of histone methylation inhibition by focusing on identifying inhibitors of specific HMTs as targets for a new generation of therapeutics. Citation Format: Bing Zhu, Ailing Hong, Chris Hebel, Xiaochuan Zhou, Xiaolian Gao. Site specific profiling of histone methyltransferases in cancer cells using histone peptide microarray containing a comprehensive set of histone peptides. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4235. doi:10.1158/1538-7445.AM2013-4235
Brain Stem Compression in Rheumatoid Arthritis
Authors: James W. Mayer
Journal: JAMA (1976)

INVOLVEMENT of the cervical spine, particularly the atlanto-axial (C-1 to C-2) area, by rheumatoid arthritis (RA) may result in serious complications, including quadraparesis, vertebral artery insufficiency, and death.<sup>1</sup>Pathologic conditions of the cervical spine are common in RA and may occur in as many as 86% of patients with this disease.<sup>1</sup>The incidence of roentgenographic evidence of serious C-1 to C-2 subluxations has been reported as high as 25%.<sup>1</sup>The present report describes an unusual patient with spinal cord and medullary compression caused by rheumatoid involvement of these two vertebrals and reviews the diagnosis and treatment of this potentially reversible but frequently overlooked complication. <h3>Report of a Case</h3> A 59-year-old woman was in good health until 1964, when RA developed. Over the ensuing ten years, she suffered from progressive disease, with subluxation of metatarsal and metaphalangeal joints, ulnar deviation of the fingers, swan neck and butonniere deformities,
Weight Gain in Depression Remitted with Antidepressants: Pharmacological or Recovery Effect?
Authors: Franco Benazzi
Journal: Psychotherapy and Psychosomatics (1998)

Depression remission is often associated with weight gain. It is not clear if weight gain is caused by a pharmacological effect of antidepressants, or if instead it is an effect of recovery from depression. The aim of this study was to try to clarify this point.One hundred consecutive unipolar/bipolar remitted depressed private practice outpatients (DSM-IV diagnoses with structured interview) were interviewed with structured questions about weight changes occurring during depression and remission. Comparisons were made between remitted weight gainers and remitted nonweight gainers.Seventy-two percent of patients showed weight gain when they remitted from depression, in comparison with their weight when they were depressed. No significant differences were found in age, gender, diagnoses, duration of remission, use of tricyclics, tricyclic-SSRI combination, benzodiazepines, neuroleptics, and mood stabilizers in remitted weight gainers versus nonweight gainers. SSRIs were significantly more used in remitted nonweight gainers. Significantly more weight loss and less weight gain when depressed were found in remitted weight gainers versus nonweight gainers.These findings suggest that weight gain in remitted depressed patients may not necessarily be a pharmacological effect of antidepressants, but may rather be an effect, at least in part, of recovery from depression.
DUTY OF THE PHYSICIAN TO THE PUBLIC.
Authors: JAMES W. COKENOWER
Journal: JAMA (1896)

The tendency among modern medical writers has been to present a subject pertaining to some special branch of medical and surgical science and, especially, to ride some "hobby" or pet theme, wholly ignoring the more practical thoughts which come before us in everyday life. It is the purpose of this paper to point out briefly some of these errors, and it will make no pretense to science, but endeavor to present such thoughts as come under the writer's observation almost daily, while engaged in a general practice. And, it seems to me, they are of sufficient importance to invite the attention of the entire medical fraternity. It is true that science, and advanced theories of medicineand surgery have done much, and no doubt will do more, and are not to be disparaged, but they have in the past, it seems to me, been prosecuted to the detriment of the more
Institute of Therapeutics
Authors: A. C. Dornhorst, J. M. Robson, R. T. Williams
Journal: BMJ (1964)

The relationship between clinicopathological findings and the long-term prognosis was investigated in 42 breast cancer patients in whom aneusomy was detected for chromosomes 1, 11 and 17. The frequencies of aneusomy of those chromosomes were 78.6%, 47.5% and 52.5%, respectively, and more than 90% of anomalies consisted of polysomy. The relationship between aneusomy and the clinicopathological findings showed a statistical correlation with a high histological grade in the case of polysomy of chromosome 17 compared with disomy, indicating a tendency for a high incidence of lymph node metastasis. Analysis of the survival data revealed that the prognosis was poor when there was polysomy of chromosomes 1 or 11. These results indicate the possibility that aneusomy of chromosomes 1, 11 and 17 can serve as prognostic factors of poor outcome in breast cancer patients.
A candidate gene analysis of three related photosensitivity disorders: cutaneous lupus erythematosus, polymorphic light eruption and actinic prurigo
Authors: T.P. Millard, E. Kondeatis, A. Cox, A.G. Wilson, S.A. Grabczynska, B.S. Carey, C.M. Lewis, M.A. Khamashta, G.W. Duff, G.R.V. Hughes, J.L.M. Hawk, R.W. Vaughan, J.M. McGregor
Journal: British Journal of Dermatology (2001)

Journal Article A candidate gene analysis of three related photosensitivity disorders: cutaneous lupus erythematosus, polymorphic light eruption and actinic prurigo Get access T.P. Millard, T.P. Millard Department of Photobiology, St John's Institute of Dermatology and Dr T.P.Millard, 57 Westfield Road, Benson, Oxon OX10 6NJ, U.K. E‐mail: thomas.millard@kcl.ac.uk Search for other works by this author on: Oxford Academic Google Scholar E. Kondeatis, E. Kondeatis South Thames Tissue Typing Laboratory and Search for other works by this author on: Oxford Academic Google Scholar A. Cox, A. Cox Division of Molecular and Genetic Medicine, University of Sheffield, Sheffield, U.K. Search for other works by this author on: Oxford Academic Google Scholar A.G. Wilson, A.G. Wilson Division of Molecular and Genetic Medicine, University of Sheffield, Sheffield, U.K. Search for other works by this author on: Oxford Academic Google Scholar S.A. Grabczynska, S.A. Grabczynska Department of Photobiology, St John's Institute of Dermatology and Search for other works by this author on: Oxford Academic Google Scholar B.S. Carey, B.S. Carey South Thames Tissue Typing Laboratory and Search for other works by this author on: Oxford Academic Google Scholar C.M. Lewis, C.M. Lewis Division of Medical and Molecular Genetics, King's College, London, U.K. Search for other works by this author on: Oxford Academic Google Scholar M.A. Khamashta, M.A. Khamashta Louise Coote Lupus Unit, St Thomas' Hospital, London SE1 7EH, U.K. Search for other works by this author on: Oxford Academic Google Scholar G.W. Duff, G.W. Duff Division of Molecular and Genetic Medicine, University of Sheffield, Sheffield, U.K. Search for other works by this author on: Oxford Academic Google Scholar G.R.V. Hughes, G.R.V. Hughes Louise Coote Lupus Unit, St Thomas' Hospital, London SE1 7EH, U.K. Search for other works by this author on: Oxford Academic Google Scholar ... Show more J.L.M. Hawk, J.L.M. Hawk Department of Photobiology, St John's Institute of Dermatology and Search for other works by this author on: Oxford Academic Google Scholar R.W. Vaughan, R.W. Vaughan South Thames Tissue Typing Laboratory and Search for other works by this author on: Oxford Academic Google Scholar J.M. McGregor J.M. McGregor Department of Photobiology, St John's Institute of Dermatology and Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 145, Issue 2, 1 August 2001, Pages 229–236, https://doi.org/10.1046/j.1365-2133.2001.04339.x Published: 01 August 2001
Autoradiographic evaluation of myocardial collateral circulation in the canine heart
Authors: P. F. COHN, E. S. KIRK, J. M. DOWNEY, E. H. SONNENBLICK, R. GORLIN
Journal: Cardiovascular Research (1973)

Although islands of viable muscle are found in areas of myocardial infarction, standard techniques for studying myocardial collateral circulation have not satisfactorily demonstrated a similar heterogeneous pattern of tissue blood flow. In the present study, a non-uniform distribution of myocardial blood flow has been graphically demonstrated in dogs after experimental coronary artery occlusion by use of a macroscopic autoradiographic technique. Patchy blood flow was found in areas of both brief and prolonged ischaemia. These autoradiographic findings were confirmed by similar studies using a fluorescent dye.