tbuckley/cabot-search huggingface dataset:
Adynamic Basal Diastolic Murmurs.
Authors: M. Leo Hughes
Journal: Annals of Internal Medicine (1965)

s1 November 1965Adynamic Basal Diastolic Murmurs.M. Leo Hughes Jr., M.D., Robert L. King, M.D., F.A.C.P.M. Leo Hughes Jr., M.D.Search for more papers by this author, Robert L. King, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-5-902_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt is generally considered that the presence of a diastolic murmur indicates significant heart disease. Ten asymptomatic patients with Grade 2 4/6 high pitched diastolic decrescendo murmurs along the left sternal border, characteristic of semilunar valve insufficiency, have been followed up 5 or more years. All patients have maintained, without change, normal chest X rays, electrocardiograms, and cardiac fluoroscopic examinations. Auscultatory and phonocardiographic findings have remained constant. Cardiac catheterization and angiocardiographic studies revealed no abnormalities.All patients were males, ages 20 to 48, who regularly participated, without restrictions, in physically active sports. They were free of all cardiorespiratory symptoms. There was... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Seattle, Washington PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1965Volume 63, Issue 5Page: 902-902KeywordsCardiovascular therapyCatheterizationElectrocardiographySportsThorax Issue Published: 1 November 1965 PDF downloadLoading ...
Abstract A37: Correlation of EGFR ligand expression with response to classical or targeted therapies in non-small cell lung cancer xenografts
Authors: Iduna Fichtner, Jana Rolff, Maria Rivera, Johannes Merk
Journal: Clinical Cancer Research (2010)

Abstract Increased levels of the epidermal growth factor receptor (EGFR) and its cognate ligands are common in non-small cell lung cancer (NSCLC) and correlate with a poor prognosis. In the last years targeted therapies against the EGFR were developed, but results of clinical trials were rather disappointing. The identification of biomarkers in NSCLC as predictive factors for an individualized therapy is urgently needed. Twenty six xenografts were established from fresh surgical material from NSCLC patients and characterized with regard to their sensitivity to four cytostatics (Carboplatin, Etoposide, Paclitaxel, Gemcitabine) and two EGFR-inhibitors (Cetuximab, Erlotinib). The expression of EGFR and its ligands epidermal growth factor (EGF), transforming growth factor alpha (TGFα), epiregulin and amphiregulin were examined at mRNA and protein level. Three ligands, which bind exclusively to EGFR (EGF, TGFα and amphiregulin) showed correlations to the mRNA expression of the receptor. Also the mRNA-levels of amphiregulin and epiregulin correlated with each other. The responsiveness towards Etoposide correlated negatively with the EGF-protein (r=-0.479, P&amp;lt;0.05) and with the EGFR-mRNA (r=-0.663, P&amp;lt;0.01) expression. This could mean that the expression of the EGFR-pathway related molecules is able to protect tumor cells from the induction of apoptosis through a cytostatic drug. The response rate to Gemcitabine showed a negative correlation with the TGFα-mRNA level (r=-0.525, P&amp;lt;0.01). Controversially, the amphiregulin-mRNA level correlated positively with the responsiveness to Gemcitabine (r=0.553, P&amp;lt;0.01). A high level of TGFα-mRNA correlated with the resistance to Erlotinib (r=-0.456, P&amp;lt;0.05). The epiregulin-mRNA level showed a positive correlation concerning the sensitivity towards Cetuximab (r=0.476, P&amp;lt;0.05). High EGFR levels seem to be indicative for the resistance to Erlotinib (r=0.636, P&amp;lt;0.05) in squamous cell carcinomas and for the sensitivity to Cetuximab (r=-0.888, P&amp;lt;0.05) in adenocarcinomas. The results of the present study showed the role of the EGFR activated pathways in the dynamics of tumor progression in NSCLC on the one hand and reflect the high level of redundancy and interrelationships of the EGFR signalling pathway on the other hand. The patient-derived NSCLC models are suitable tools for the identification of biomarkers and their regulation mechanisms in a clinically related and standardized way. Citation Information: Clin Cancer Res 2010;16(7 Suppl):A37
Severe bleeding complications caused by an autoantibody against the B subunit of plasma factor XIII: a novel form of acquired factor XIII deficiency
Authors: Éva Ajzner, Ágota Schlammadinger, Adrienne Kerényi, Zsuzsanna Bereczky, Éva Katona, Gizella Haramura, Zoltán Boda, László Muszbek
Journal: Blood (2008)
A Critique of the Tranquilizing Drugs, Chlorpromazine and Reserpine, in Neuropsychiatry
Authors: Harry Freeman
Journal: New England Journal of Medicine (1956)

THE advent of the tranquilizing drugs has aroused a ferment in psychiatric quarters that to the laity has implied the coming of the millennium in this phase of medicine. In view of the history of previous somatic therapies with similarly enthusiastic claims, it behooves the medical profession to evaluate the present results with a judicial and skeptical eye. It is the purpose of this paper to review the highlights in the literature on these drugs. The paper will be confined to the results obtained through the administration of chlorpromazine and reserpine, since other drugs have been reported in too few . . .
Severe neurological abnormalities associated with a mutation in the zinc-finger domain in a group A xeroderma pigmentosum patient
Authors: T. MAEDA, K. SATO, H. MINAMI, H. TAGUCHI, K. YOSHIKAWA
Journal: British Journal of Dermatology (2006)

All the reported Japanese patients with group A xeroderma pigmentosum (XP) have two or three mutations at codon 116 in exon 3, codon 228 in exon 6, and the splicing acceptor site of intron 3 of XP group A complementing (XPAC) gene. A homozygote (XP390S) with a nonsense mutation at codon 228 has less severe neurological abnormalities than patients with the splicing mutation at the acceptor site of intron 3. As homozygotes for the nonsense mutation at codon 116, which truncates a carboxyl‐terminal site of XPAC protein at an early part of its zinc‐finger domain, have not been reported previously, the possible severity of associated neurological abnormalities was not known. We report a group A XP patient, XP180S, who had neurological abnormalities which were more severe than those in patients homozygous for the splicing mutation. The polymerase chain reaction product from exon 3 of the patient's XPAC gene was digested completely into three fragments by MseI restriction endonuclease. Thus, the patient was homozygous for the mutation at codon 116.
Near-Infrared Spectroscopy Predicts Cardiovascular Outcome in Patients With Coronary Artery Disease
Authors: Rohit M. Oemrawsingh, Jin M. Cheng, Héctor M. García-García, Robert-Jan van Geuns, Sanneke P.M. de Boer, Cihan Simsek, Isabella Kardys, Mattie J. Lenzen, Ron T. van Domburg, Evelyn Regar, Patrick W. Serruys, K. Martijn Akkerhuis, Eric Boersma
Journal: Journal of the American College of Cardiology (2014)
Book Review Genetics in Endocrinology (Modern Endocrinology Series.) Edited by John D. Baxter, Shlomo Melmed, and Maria I. New. 763 pp., illustrated. Philadelphia, Lippincott Williams &amp; Wilkins, 2002. $169. 0-7817-1496-6
Authors: Gerhard Baumann
Journal: New England Journal of Medicine (2002)
BNIP3 Expression Is Linked with Hypoxia-Regulated Protein Expression and with Poor Prognosis in Non–Small Cell Lung Cancer
Authors: Alexandra Giatromanolaki, Michael I. Koukourakis, Heidi M. Sowter, Efthimios Sivridis, Spencer Gibson, Kevin C. Gatter, Adrian L. Harris
Journal: Clinical Cancer Research (2004)

Abstract BNIP3 is a proapoptotic protein regulated by hypoxia-inducible factor 1. We analyzed BNIP3 expression in 105 tumor samples from early operable, non-small lung cancer and the relationship of expression to hypoxia-inducible factor 1α, other hypoxia-regulated pathways, and prognosis. There was strong cytoplasmic expression in &amp;gt;10% of cells in 40 of 105 cases. BNIP3 expression was associated significantly with high hypoxia-inducible factor 1α (P = 0.003), carbonic anhydrase 9 (P = 0.04), and was inversely associated with bcl-2 expression (P = 0.009). High BNIP3 expression was a major independent factor for overall survival. Thus, high expression of a hypoxia regulated proapoptotic pathway was associated with a selection of an aggressive phenotype in vivo.
Milburn to monitor implementation of NICE guidance
Authors: A. Ferriman
Journal: BMJ (2000)

The health secretary, Alan Milburn, has announced that explicit monitoring is to be introduced into the NHS to ensure that every health authority and NHS trust in England and Wales is taking “full and proper account” of each appraisal from the National Institute for Clinical Excellence (NICE).

“Monitoring will take place shortly after the publication of each NICE appraisal and then six months later to track progress on implementation,” he told …
Response to Letter by Sacks
Authors: Giorgio Mello, Elena Parretti, Riccardo Cioni
Journal: Diabetes Care (2002)

The response letter by Sacks (1) in this issue of Diabetes Care acknowledges that our study (2) was meticulous, but raises concerns as to the reliability of results, and reminds that hematocrit influences glucose values determined on whole blood. In this respect, some observations can be made.

First, the women involved in our study were absolutely free to leave the glucose profile monitoring program, which indeed was discontinued by a significant proportion of them (10%). This does not imply that the remainders were reliable but lends some credence to the fact that they performed and recorded the appropriate determinations at the right time. In addition, it is true that Accutrend α can only record the …
Crystal-induced neutrophil activation. III. Inflammatory microcrystals induce a distinct pattern of tyrosine phosphorylation in human neutrophils.
Authors: M Gaudry, C J Roberge, R de Médicis, A Lussier, P E Poubelle, P H Naccache
Journal: Journal of Clinical Investigation (1993)

The activation of human neutrophils by monosodium urate and calcium pyrophosphate dihydrate crystals is believed to play a critical role in the pathogenesis of arthritides such as acute gout and pseudogout, respectively. In this study, we investigated the potential involvement of tyrosine phosphorylation in microcrystal-mediated activation of human neutrophils. Immunoblot analysis with antiphosphotyrosine antibodies demonstrated that triclinic monosodium urate and calcium pyrophosphate dihydrate crystals stimulated a time- and concentration-dependent tyrosine phosphorylation of at least five proteins (pp130, 118, 80, 70, and 60). While phosphoprotein (pp) 118 and pp70 were the major phosphorylated substrates, pp70 was the dominant one in reactivity with antiphosphotyrosine antibodies. When the temporal patterns, as well as the levels of tyrosine phosphorylation for both types of crystals were compared, monosodium urate crystals were found to be more potent activators than calcium pyrophosphate dihydrate crystals. The tyrosine phosphorylation patterns induced by microcrystals differed from those stimulated by other soluble (FMLP, C5a, or leukotriene B4) or particulate (unopsonized latex beads or zymosan) agonists which stimulated preferentially the tyrosine phosphorylation of pp118. The ratio of the intensities of pp118 and pp70 were specific of the stimulation with microcrystals when compared to those observed with the other soluble or particulate agonists. Colchicine, a drug used specifically in the treatment of gout and pseudogout, inhibited microcrystal-induced tyrosine phosphorylation, while beta- and gamma-lumicolchicine were without effect. On the other hand, colchicine failed to inhibit FMLP-induced tyrosine phosphorylation. Furthermore, while colchicine inhibited the activation of the NADPH oxidase by microcrystals, it, on the other hand, enhanced the production of superoxide anions by FMLP. Taken together, these results (a) demonstrate that tyrosine phosphorylation is involved in the mechanism of activation of human neutrophils induced by microcrystals; and (b) suggest, on the basis of the characteristics of the observed patterns of tyrosine phosphorylation, that this response may be specific to the microcrystals and relevant to their phlogistic properties.
The Growing Global Public Health Crisis and How to Address It
Authors: A. Mark Clarfield
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
1016 LOW RATES OF NUCLEOS(T)IDE-ASSOCIATED ADVERSE EVENTS IN THE LONG-TERM EXPERIENCE WITH ENTECAVIR
Authors: M. Manns, U.S. Akarca, T.-T. Chang, W. Sievert, S.-K. Yoon, N. Tsai, A. Min, A. Pangerl, S. Beebe, M. Yu, S. Wongcharatrawee
Journal: Journal of Hepatology (2010)
Plasma cytokine levels in thrombotic thrombocytopenic purpura
Authors: Hideo Wada, Toshihiro Kaneko, Michiaki Ohiwa, Motoaki Tanigawa, Shigehisa Tamaki, Nobuyuki Minami, Hoyu Takahashi, Katsumi Deguchi, Takeshi Nakano, Shigeru Shirakawa
Journal: American Journal of Hematology (1992)

Abstract Plasma cytokine levels were examined in 13 patients with thrombotic thrombocytopenic purpura (TTP). Auto‐antibodies, platelet‐associated immunoglobulin G, and platelet aggregating factor were detected in many of these patients and high‐molecular‐weight bands of von Willebrand factor multimers were reduced in 9 of 10 patients examined. Complete remission (CR) was attained in 7 of the 13 patients, but 6 died. Tumor necrosis factor (TNF), Interleukin (IL)‐1β, IL‐6, and soluble IL‐2 receptor showed marked increases at onset and decreased at CR. The prognosis tended to be poor in patients with increased IL‐6 and soluble IL‐2 receptor levels. These findings suggest that immunological mechanisms, such as the activation of macrophage, are involved in the pathogenesis of TTP and are reflected in the plasma cytokine levels. © 1992 Wiley‐Liss, Inc.
Engulfment of apoptotic cells expressing HCV proteins leads to differential chemokine expression and STAT signaling in human dendritic cells
Authors: Anne M. Wertheimer, Stephen J. Polyak, Rachel Leistikow, Hugo R. Rosen
Journal: Hepatology (2007)

In the majority of cases, infection with hepatitis C virus (HCV) becomes chronic and is often associated with impaired innate and adaptive immune responses. The mechanisms underlying viral persistence and lack of protective immunity are poorly understood. Considering that dendritic cells (DCs) play critical roles in initiating and modulating immune responses, we explored the effect of HCV proteins on DC gene and protein expression, phenotype, and function. Human DCs were generated following plastic adherence of monocytes and culture with granulocyte-macrophage colony-stimulating factor and interleukin-4 (IL-4) from normal subjects. Autologous nonadherent peripheral blood mononuclear cells were infected with vaccinia constructs expressing various HCV proteins (core-E1, NS5A, NS5B) or an irrelevant protein β-galactosidase (β-gal) as the control, induced to undergo apoptosis, then co-cultured with DCs. Between 2% and 10% of the genes probed in a cDNA nylon array were differentially regulated within DCs that had engulfed HCV proteins. In particular, the presence of intracellular NS5A led to increased transcriptional and protein expression of IL-8 (CXCL-8), a chemokine with proinflammatory and anti-interferon properties, and impaired interferon induction of signal transducers and activators of transcription 1 (STAT1) serine and tyrosine and STAT2 tyrosine phosphorylation. Conclusion: These data provide novel mechanisms by which HCV subverts antiviral host immunity. (Hepatology 2007;45:1422–1432.)
Faster-Z Evolution Is Predominantly Due to Genetic Drift
Authors: J. E. Mank, K. Nam, H. Ellegren
Journal: Molecular Biology and Evolution (2009)

Genes linked to sex chromosomes may show different levels of functional change than autosomal genes due to different evolutionary pressures. We used whole-genome data from zebra finch-chicken orthologs to test for Faster-Z evolution, finding that Z-linked genes evolve up to 50% more rapidly than autosomal genes. We combined these divergence data with information about sex-specific expression patterns in order to determine whether the Faster-Z Effect that we observe was predominantly the result of positive selection of recessive beneficial mutations in the heterogametic sex or primarily due to genetic drift attributable to the lower effective population size of the Z chromosome compared with an autosome. The Faster-Z Effect was no more prevalent for genes expressed predominantly in females; therefore, our data indicate that the largest source of Faster-Z Evolution is the increased levels of genetic drift on the Z chromosome. This is likely a product of sexual selection acting on males, which reduces the effective population size of the Z relative to that of the autosomes. Additionally, this latter result suggests that the relative evolutionary pressures underlying Faster-Z Evolution are different from those in analogous Faster-X Evolution.
Acute Renal Failure After Excretory Urography in Diabetic Patients
Authors: JOSE A. DIAZ-BUXO
Journal: Annals of Internal Medicine (1975)

Currently used contrast media for excretory urography are generally considered safe even in the presence of renal insufficiency. Isolated reports of acute oliguric renal failure in diabetic patients after excretory urography have been documented. We describe eight such patients who developed this complication. The approximate incidence of recognized acute oliguric renal failure in diabetics undergoing excretory urography was 2 in 1000 as compared with none in more than 100 000 procedures done in nondiabetic patients. Six of the diabetic patients with acute renal failure recovered; two required hemodialysis, never regaining self-sustaining renal function. If detected early, acute renal failure in this setting can often be managed conservatively. Attempts to induce diuresis have been discouraging.
Remotely Controlled Mandibular Positioner Predicts Efficacy of Oral Appliances in Sleep Apnea
Authors: Willis H. Tsai, Juan-Carlos Vazquez, Tsutomu Oshima, Leslie Dort, Brian Roycroft, Alan A. Lowe, Eric Hajduk, John E. Remmers
Journal: American Journal of Respiratory and Critical Care Medicine (2004)

Anterior mandibular positioners (AMPs) have become increasingly popular as alternatives to continuous positive airway pressure for the treatment of obstructive sleep apnea. However, widespread acceptance of AMP is limited by an efficacy rate of 50-80% and an inability to predict which patients will respond to therapy. We evaluated 23 patients with obstructive sleep apnea (respiratory disturbance index [RDI] >/= 15 h(-1)) with a remotely controlled mandibular positioner (RCMP), a temporary oral appliance that can advance or retract the mandible in a process analogous to changing the mask pressure during a continuous positive airway pressure titration study. We hypothesized that the elimination of respiratory events and significant nocturnal oxygen desaturation during an RCMP overnight study would predict AMP efficacy, as defined by an absolute reduction in RDI to less than 15 h(-1), a relative reduction in RDI of more than 30% from baseline, and a subjective improvement in symptoms. AMP compliance was 82%, and therapeutic efficacy was 53%. Among compliant patients, the positive and negative predictive value of an RCMP study in predicting AMP treatment success was 90% and 89%, respectively. An overnight RCMP study is highly predictive of AMP response.
Cardiovascular Risk Stratification in Older Patients
Authors: Martin Schillinger
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reflex effects of aerosolized histamine on phrenic nerve activity.
Authors: A I Pack, B C Hertz, J F Ledlie, A P Fishman
Journal: Journal of Clinical Investigation (1982)

Studies were conducted in anesthetized, paralyzed dogs on the effect of aerosolized histamine on phrenic nerve activity. The paralyzed dogs were ventilated in phase with their recorded phrenic nerve activity at a constant inspiratory flow-rate, using a cycle-triggered ventilator. Phrenic nerve activity was measured before and during administration of aerosolized histamine while the inspiratory flow-rate and arterial blood gases were kept constant. In addition, before and after histamine, phrenic nerve activity was recorded for single bursts during which the ventilator was switched off. The effects of histamine on respiratory resistance were prevented by prior administration of isoproterenol and atropine. Although no changes occurred in respiratory resistance, histamine increased the instantaneous magnitude of phrenic nerve activity. The effect was evident early in the inspiratory period and was found even when the lungs were not inflated. Inflation of the lungs excited phrenic nerve activity; this effect increased after histamine. All of these actions of histamine were abolished by vagotomy. We conclude that histamine increased phrenic nerve activity during inspiration by a vagal reflex.