tbuckley/cabot-search huggingface dataset:
Ectopic Calcification In Sarcoidosis
Authors: Norman Fujita
Journal: JAMA (1974)

To the Editor.—  Hypercalcemia in some patients with sarcoidosis may lead to calcification in the kidneys and other tissues, including the soft tissues of the shoulder, the pulp of the fingers, the metatarsophalangeal joint of the big toe, and the ear cartilage. 1-4 We report an example.  Report of a Case.—  A 65-year-old woman complained in 1962 of blurry vision and shortness of breath on exertion. The chest roentgenogram showed bilateral diffuse reticulonodular infiltration. Noncaseating sarcoid granulomas were found on a scalene-node biopsy negative for acid-fast bacteria. The patient was treated with corticosteroids.  During the course of her illness, the patient was plagued by recurrent uveitis, chorioretinitis, and glaucoma. In 1963, an x-ray film taken when the patient complained of pain in the abdomen revealed a calculus in the lower pole of the right kidney. In 1964, cor pulmonale was controlled with digitalis and diuretics.  During the course of the
Racial Differences in Serum Total Bilirubin Levels in Health and in Disease (Pernicious Anemia)
Authors: Ralph Carmel
Journal: JAMA (1985)

Common usage prescribes a single normal range for serum bilirubin levels. However, we have not only confirmed that men have higher levels than women but have discovered significant racial differences as well. Among 1,538 healthy Americans, blacks had lower mean bilirubin levels than whites of European origin, Latin Americans, and Asians. These racial differences, which were more pronounced among women than men, were maintained in pernicious anemia. Even though bilirubin levels rose in our 174 patients with this disease, they continued to be lower among blacks than among whites and Latin Americans. Moreover, the actual bilirubin level changes caused by pernicious anemia were themselves smaller among blacks. The racial differences, thus, persisted in pernicious anemia despite similar degrees of anemia, whereas the sex differences disappeared. We suggest that the lower serum bilirubin levels in blacks in health and disease do not stem primarily from lower bilirubin production than in whites. (<i>JAMA</i>1985;253:3416-3418)
Transient Childhood Strokes From Internal Carotid Stenosis
Authors: James P. Isaacs
Journal: JAMA (1969)

A seven-year history of repeated right-sided weakness in a 10-year-old child was diagnosed by carotid arteriograms as extracranial stenosis of the left internal carotid artery. Arteriograms also demonstrated multiple congenital abnormalities of the collateral circulation at the circle of Willis. The attacks were triggered by anxiety states which developed from parental disciplinary confrontation or athletic competition. There have been no strokes since the carotid stenosis was corrected surgically five years ago. The stenosis was secondary to scarring, probably of both traumatic and inflammatory origin.
Multifunctional nanoparticles co-delivering Trp2 peptide and CpG adjuvant induce potent cytotoxic T-lymphocyte response against melanoma and its lung metastasis
Authors: Zhenghong Xu, Srinivas Ramishetti, Yu-Cheng Tseng, Shutao Guo, Yuhua Wang, Leaf Huang
Journal: Journal of Controlled Release (2013)
Enteritis and colitis associated with mefenamic acid
Authors: R. Williams, G Glazer
Journal: BMJ (1983)

Voicing opposition to "apartheid" is, in most sectors of South African society, as prudent and fashionable as it is outside South Africa.It is unfortunate that the South African newspapers referred to by Mr Bennun are unavailable to most BMJ readers.A reading in toto of each of the articles referred to does not in fact give the same impression of maltreatment and malpractice produced by Mr Bennun's extracts.65Also, in the case of the trial of Mr Motaung, although Mr Bennun refers to the Rand Daily Mail of 28 and 29 July 1982, and the Sowetan of 29 July, he does not refer to their 30 July issues.On this date, the Rand Daily Mail reported the judge to have summed up: that the accused had lied about the extent of his injuries and the pain he had suffered; that his bullet wounds were not that serious; that' the security police had not deliberately kept him from seeing a doctor or sending him to hospital; that his demeanour in the witness box was thoroughly unsatisfactory; and that he had fabricated his evidence.9According to the Sowetan, the judge found the accused to have been a shrewd person in the witness box and quoted the district surgeon as saying that one shot had grazed the accused's private parts and that he had also suffered a super- ficial wound.10The events giving rise to the trial consisted of multiple killings, attempted killings, and attacks on police and power stations by a gang armed with AK-47 rifles, TNT explosives, and hand grenades.5Mr Bennun is making a sociolegal study of the application of South African security laws.This is, I imagine, a feasible undertaking because of the wealth of independent news- paper reporting and reliable documentation of open court hearings, a set of circumstances now unique in Africa.Without being entirely rhetorical, may I ask Mr Bennun how he would do a similar study of African Common- wealth countries ?What would be the sources of one's research material ?
Electrophysiological effects of glucose-insulin-potassium on sinus node function in patients with and without sinus node dysfunction
Authors: J. SENGES, J. BRACHMANN, E. CZYGAN, I. RIZOS, W. LENGFELDER, W. KUBLER
Journal: Cardiovascular Research (1982)

The electrophysiological effects of glucose (100 g)-insulin (20 U)-potassium (10 mmol·litre−1) infusion (GIK) on three parameters of sinus node function were studied in 14 control subjects (mean age 53±14 yr) and 11 patients (mean age 50±17 yr) with sinus node dysfunction (SND). In a first series of experiments the response to GIK was examined in nine control and 11 SND patients. Following GIK, the mean spontaneous cycle length decreased by 17% (671 to 560 ms; P<0.01) in the control group and by 33% (1066 to 715 ms; P<0.001) in the SND patients; this difference between both groups was statistically significant (P<0.01). In the control group mean corrected sinus node recovery time (CRST) and calculated sinoatrial conduction time (SACT; n=6) were not significntly altered after GIK. In SND patients GIK decreased the mean value of CSRT by 40% (693 to 416 ms; P<0.05) and of calculated SACT (n=6) by 27% (130 to 95 ms; P<0.05); prolonged secondary pauses following termination of rapid atrial pacing in SND patients were also shortened. In a second series of experiments, mannitol (100 g, iv) was administered in five control patients but had no significant effect on the electrophysiological parameters tested. Plasma levels of glucose were significantly increased, by 500% (P<0.01), after GIK; plasma potassium and sodium concentrations decreased by 7 and 5% (P<0.05). The results indicate that GIK had a beneficial effect on sinus node dysfunction.
Intravenous short-term infusion of streptokinase in acute myocardial infarction.
Authors: R Schröder, G Biamino, E R von Leitner, T Linderer, T Brüggemann, J Heitz, H F Vöhringer, K Wegscheider
Journal: Circulation (1983)

Short-term i.v. infusion of streptokinase was performed in 93 patients within 6 hours after the onset of acute myocardial infarction. Twenty-six patients underwent angiography in the acute phase (group A) and 52 underwent angiography in the fourth week only (group B); 15 patients had no angiography. Seven patients died during the hospital stay and six suffered nonfatal reinfarctions. There were no bleeding complications. In 11 of 21 group A patients, occluded coronary arteries were opened within 1 hour after the streptokinase infusion was started. In 84% of groups A and B, the infarct-related coronary artery was patent in the fourth week. In 75% of the patent arteries, the residual luminal diameter stenosis was less than 70%. According to serial serum CK-MB curves, recanalization was achieved mostly within 1-2 hours. Myocardial salvage was indicated by improvement in local contraction disorders in the recanalized group A patients and by the significant relationship between infarct size and time from symptom onset to treatment in group B. These data suggest that a high-dose, short-term, i.v. infusion of streptokinase is a safe and efficient method of restoring coronary blood flow. Expeditious initiation of i.v. streptokinase infusion is a critical determinant for early recanalization and salvage of myocardium. Patients with thrombotically subtotal occlusion probably receive the most benefit. Evaluation of the true impact on survival and myocardial function will require controlled clinical trials.
Pregnancy Following Renal Transplantation in a Patient with Insulin-dependent Diabetes Mellitus
Authors: Frank Vinicor, Alan Golichowski, Ronald Filo, E J Smith, Douglas Maxwell
Journal: Diabetes Care (1984)

Renal transplantation and peritoneal or hemodialysis are therapeutic options increasingly available to diabetic patients with uremia. We report a patient with insulin-dependent diabetes mellitus (IDDM) and advanced retinopathy and nephropathy who had three pregnancies. Her first pregnancy resulted in a living female with Pierre-Robin syndrome and arthrogryposis. The second pregnancy, 8 mo post-kidney transplantation, necessitated a therapeutic abortion for an anencephalic fetus. Her third pregnancy, 22 mo after kidney transplantation, was associated with intensive diabetes management and resulted in delivery by cesarean section of a healthy boy. Renal and retinal function remained stable during both her second and third pregnancies. As more patients with IDDM achieve fertility post-renal transplantation, aggressive principles of diabetes regulation need to be expanded to include consideration of the interaction of the post-kidney-transplant state and diabetes mellitus during pregnancy.
Caveolar transport through nasal epithelium of birch pollen allergen Bet v 1 in allergic patients
Authors: Sakari Joenväärä, Pirkko Mattila, Jutta Renkonen, Antti Mäkitie, Sanna Toppila-Salmi, Mikko Lehtonen, Paula Salmi, Satu Lehti, Jarno Mäkinen, Raija Sormunen, Timo Paavonen, Risto Renkonen
Journal: Journal of Allergy and Clinical Immunology (2009)
Balanced Salt Solution in the Treatment of Hemorrhagic Shock
Authors: Robert N. McClelland, G. Tom Shires, Charles R. Baxter, C. Dale Coln, James Carrico
Journal: JAMA (1967)

Previous studies show a decreased mortality from hemorrhagic shock when Ringer's lactate solution is given intravenously in addition to replacement of shed blood. The improved survival rate seems related to restoration of a disproportionate extracellular fluid reduction occurring with hemorrhagic shock.<sup>1</sup> The objectives of this study were (1) to define some of the physiological effects of the treatment of hemorrhagic shock with blood replacement and Ringer's lactate solution, and (2) to investigate the theoretical objection that Ringer's lactate solution may aggravate lactic acidosis when used to treat shock. <h3>Materials and Methods</h3> Twenty-four previously splenectomized mongrel dogs ranging in weight from 17 to 26 kg (38 to 58 lb) were anesthetized with pentobarbital given intravenously and breathing was controlled by a respirator using room air. Bilateral femoral artery and vein and external jugular vein cannulizations were done. Mean femoral arterial blood pressure and pulse rate were monitored continuously with a
Portrait of a Lady
Authors: M. Therese Southgate
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Late-onset warfarin-induced skin necrosis: case report and review of the literature
Authors: D.W. Essex, S.S. Wynn, D.K. Jin
Journal: American Journal of Hematology (1998)

Warfarin-induced skin necrosis is a rare complication of therapy with warfarin or other coumarin derivatives. When it occurs it usually appears 3 to 6 days after initiation of therapy and almost always between days 1 and 10. We report a case of late-onset (16 days after initiation of therapy) warfarin-induced skin necrosis and review the literature on this rarely reported variant of warfarin-induced skin necrosis. The skin lesion in our patient was not associated with either deficiency of protein C or resistance to activated protein C. Am. J. Hematol. 57:233–237, 1998. © 1998 Wiley-Liss, Inc.
Suicide Rates for Young People-Reply
Authors: P. C. Holinger
Journal: JAMA (1988)

<h3>In Reply.</h3> —In using epidemiologic data to understand a phenomenon as complex and multidetermined as suicide among youth, it seems best to examine data over extended time periods to avoid false conclusions based on short-term trends. Suicide rates for 15- to 24-year-olds throughout this century in the United States reached their lowest point in the 1940s and 1950s (National Center for Health Statistics, unpublished data, 1920 to 1985).<sup>1</sup>Beginning in the mid-1950s, the suicide rates increased steadily to the high rates of the late 1970s.<sup>2,3</sup>These suicide death rates, per 100 000 population, are outlined in the following tabulation. This shift represented an increase of 234% for 15- to 24-year-olds. In the years 1978 to 1985, the rates for 15- to 24-year-olds have varied between 11.9 and 12.9 per 100 000 population (for 15-to 19-year-olds, the rates varied between 8.0 and 10.0; for 20- to 24-year-olds, between 14.8
The medical ethics of the battlefield
Authors: D. K. Sokol
Journal: BMJ (2011)

Technological advances in the treatment of combatants raise new ethical issues

Athena, goddess of war, gave Asclepius two vials of the Medusa’s blood. The blood from Medusa’s left side could raise the dead; the blood from her right side could kill instantly. The descendants of Asclepius—the thousands of medics who today grace the battlefields of the world—rarely use the right sided blood. Battlefield euthanasia, in which death is hastened to avoid prolonged suffering, is a controversial practice; but it is as old as war itself and, whatever laws or rules prohibit it, will doubtless continue until wars cease. In this column, however, I wish to focus on the dilemmas associated with the left sided blood. When should it be used and when forgone? And who should benefit from it?

The ability to maintain the wounded alive is nothing less than astounding. Medical advances, combined with improved body armour and rapid evacuation, have resulted in lives saved that would have been unsalvageable only 20 years ago. A recent visit to Headley Court, the Defence Medical Rehabilitation Centre, brought home to me the remarkable recoveries …
Long term follow up of small airways obstruction in patients with rheumatoid arthritis
Authors: G D WRIGHT, S D ROBERTS, M B FINCH, B MARTIN
Journal: Annals of the Rheumatic Diseases (1998)

Rheumatoid arthritis (RA) affects the respiratory system in a number of ways, including interstitial lung disease, nodules, pleural effusion, bronchiolitis obliterans, and bronchiectasis.1Isolated small airways obstruction has been described in patients with RA.2-6 Some of the studies, however, included a predominance of smokers2 or patients who were ex-smokers in the analysis.3 4 One study found no evidence of an increase in airways obstruction.7 The incidence and frequency, therefore, of small airways obstruction in non-smoking patients with RA still remains unclear and the natural history of the condition is unknown.

We obtained detailed medical and smoking histories from 54 unselected patients with RA (ARA criteria) in 1988. Patients were questioned specifically regarding the presence of cough, wheeze, dyspnoea or sputum production and had a full respiratory examination. All patients had respiratory function tests and chest radiography. The history, …
Chronic lymphocytic leukemia: Correlation of clinical course and therapeutic response with in vitro testing and morphology of lymphocytes
Authors: William H. Knospe, Stephanie Ann Gregory, Frank E. Trobaugh, Judith A. Stedronsky, Robert Schrek
Journal: American Journal of Hematology (1977)

Abstract Forty‐two patients with chronic lymphocytic leukemia (CLL) were studied for morphology of lymphocytes by light and electron microscopy (EM), in vitro responses of lymphocytes to a battery of physical and chemical agents, overall clinical status, immunologic status, course, and response to therapy. CLL lymphocytes could be classified by EM into four groups on the basis of cell size and nuclear contour and by light microscopy into two groups, small cells and large cells (lymphosarcoma cells). Patient survival did not vary with cell size or morphology as determined by light or electron microscopy. In vitro testing of CLL lymphocytes following exposure to x‐ray, PHA, DMSO 2 hr at 43°, prednisolone, glutaminase, and asparaginase permitted a separation of patients into categories of normal and abnormal in vitro responses. A normal in vitro response predicted a good response to therapy but an abnormal in vitro response did not preclude a good response to therapy. Following therapy, normalization of abnormal EM morphology and in vitro response was seen in some patients. Most patients tested had decreased serum immunoglobulins and abnormal PHA responses. There was a high incidence of infections and second neoplasms. Immunologic deficits could not be correlated with variations in lymphocyte morphology or in vitro response.
The adaptor protein SH2D1A regulates signaling through CD150 (SLAM) in B cells
Authors: Svitlana V. Mikhalap, Larysa M. Shlapatska, Olga V. Yurchenko, Maria Y. Yurchenko, Ganna G. Berdova, Kim E. Nichols, Edward A. Clark, Svetlana P. Sidorenko
Journal: Blood (2004)
The International Military Sports Council (CISM)
Authors: William S. McNamara
Journal: JAMA (1972)

The<i>Conseil International du Sport Militaire</i>(CISM), in English, the International Military Sports Council, was founded in 1948 by five western European nations and has developed to a highly respected 46 member--nation organization. The CISM Academy conducts research in sports medicine, psychology of sports, diet, new training methods, new coaching techniques, and new mass physical training programs. The council also imparts new information to all member nations in an effort to raise their overall levels of sports performance and physical fitness. Long range goals of the organization involve the use of sports in bridging the language and cultural barriers that separate men and bringing nations closer together.
Extent of atrial participation in atrioventricular-reciprocating tachycardia.
Authors: F Morady, Y S Wang, M M Scheinman, R J Sung, E Shen, W A Shapiro
Journal: Circulation (1983)

Twenty-one patients with atrioventricular (AV) bypass tracts underwent electrophysiologic studies. The bypass tract was left-sided in 15 patients, septal in five and right-sided in one patient. Orthodromic AV-reciprocating tachycardia was induced in all 21 patients, with a mean tachycardia cycle length of 342 +/- 59 msec. The introduction of single stimuli in the high right atrium during tachycardia resulted in simultaneous dissociation of the high right atrial and low septal atrial electrograms in nine patients. In six patients, high right atrial overdrive pacing during tachycardia resulted in simultaneous dissociation of the high right atrial and low septal atrial electrograms for two to five consecutive beats. All patients in whom the low septal atrial electrogram was dissociated from the tachycardia had a left-sided bypass tract. In no patient was the coronary sinus atrial electrogram dissociated from the tachycardia by high right atrial pacing. Dissociation of the low septal atrial electrogram (as recorded in the His bundle electrogram) from AV-reciprocating tachycardia suggests that the portion of the right atrium adjacent to the AV node may not be a necessary link in the tachycardia circuit. This observation suggests that the site of entry of left-sided impulses into the AV node may be different from that of right-sided impulses.
Straight from the Shoulder
Authors: John Halamka
Journal: New England Journal of Medicine (2005)

When I was a resident in emergency medicine, I spent many hours uncovering the identities of John Doe and Jane Doe patients who were unconscious, disoriented, or mute. I searched their belongings for receipts that included an address or scanned their clothing labels for a clue. Sometimes this worked. Often, hours or days passed before a family member was found who knew the patient's medical history and health care preferences. By that time, substantial worry had been endured, and often possibly unwanted medical interventions had occurred.Today, I lead the information-technology efforts at an academic health center, and I have . . .
A novel intermediate stage in the transition between short- and long-term facilitation in the sensory to motor neuron synapse of aplysia
Authors: Mirella Ghirardi, Pier Giorgio Montarolo, Eric R Kandel
Journal: Neuron (1995)

A major difference between short- and long-term memory is that long-term memory is dependent on new protein synthesis. Long-term memory can be further subdivided into a transient, initial phase that is readily susceptible to disruption and a later, more stable and persistent stage. To analyze this transition on the cellular level, we have examined the steps whereby short-term facilitation is converted to a long-term form in the sensorimotor connection of the Aplysia gill-withdrawal reflex. We found that stable long-term facilitation (at 24 hr) requires a higher concentration (100 nM) of serotonin (5-HT) than does short-term facilitation (10 nM). By using low concentrations of 5-HT, which do not produce long-term facilitation, we now have been able to explore the intermediate phases between the short- and long-term processes. By this means we have uncovered a new transient phase that involves three mechanistically different mechanisms--covalent modification, translation, and transcription--each of which can be recruited as a function of the concentration of 5-HT.
ABHD6 Blockade Exerts Antiepileptic Activity in PTZ-Induced Seizures and in Spontaneous Seizures in R6/2 Mice
Authors: Alipi V. Naydenov, Eric A. Horne, Christine S. Cheah, Katie Swinney, Ku-Lung Hsu, Jessica K. Cao, William R. Marrs, Jacqueline L. Blankman, Sarah Tu, Allison E. Cherry, Susan Fung, Andy Wen, Weiwei Li, Michael S. Saporito, Dana E. Selley, Benjamin F. Cravatt, John C. Oakley, Nephi Stella
Journal: Neuron (2014)