tbuckley/cabot-search huggingface dataset:
60. Recovery of Vestibular Function Induced by math1 Gene Delivery
Authors: Hinrich Staecker, Mark Praetorius, Douglas E. Brough
Journal: Molecular Therapy (2005)

Over expression of math1 has been demonstrated to induce generation of hair cells in the cochlea in neonatal tissue culture models of the organ of Corti and math 1 generation of hair cells has recently been shown in vivo. We have examined an in vitro organtypic culture model as well as unilateral acute and bilateral chronic models of aminoglycoside vestibular injury. Delivery of Math1 using an adenovector (Ad) resulted in the generation of hair cells in adult mouse utriclular and saccular cultures. Mice treated with aminoglycosides showed recovery of a significant portion of the vestibular neuroepithelium after AdMath1.11D was infused into the inner ear. In vitro BRDU labeling studies suggest that the recovery of vestibular hair cells is due to transdifferentiation of supporting cells. Examination of a cohort of AdMath1.11D treated animals compared to non-vector treated controls, demonstrated recovery of vestibular function using scleral search coil measurement of the horizontal vestibuo-occular reflex (hVOR). These studies suggest that math1 gene delivery may be useful for treatment of balance disorders resulting from loss of vestibular hair cells.
Cerebrospinal-Fluid Transaminase Concentrations in Clinical Cerebral Infarctions
Authors: Joseph B. Green, Desmond S. O'Doherty, Henry A. Oldewurtel, Francis M. Forster
Journal: New England Journal of Medicine (1957)

THE enzyme glutamic oxalacetic transaminase is present in all the tissues of the body except bone. It is found in highest concentration in muscle, heart, brain and liver.1 2 3 LaDue and his co-workers4 5 6 have shown experimentally and clinically that acute destruction of heart and liver tissue increases the transaminase activity of the serum. The determination of this activity has found clinical application in the diagnosis of myocardial infarction.Since the brain is also rich in this enzyme, cerebral infarctions could similarly result in a rise in serum transaminase activity. Moreover, the spinal fluid, being an integral part of the nervous system, . . .
A population‐based epidemiologic analysis of deaths from anaphylaxis in Florida
Authors: M. R. Simon, Z. D. Mulla
Journal: Allergy (2008)

Background: Previous US population‐based epidemiologic studies of anaphylactic deaths have been limited by small populations and/or few deaths. The objective of this study was to determine the 10‐year incidence of death from anaphylaxis in Florida and its descriptive epidemiology. Methods: Patients who died from anaphylaxis from 1996 to 2005 were identified from ICD‐9 and ICD‐10 codes on death certificates statewide. Age, race and gender‐specific anaphylactic death rates were calculated. Results: There were 89 deaths among Florida residents. The individuals with autopsy confirmed diagnoses, and those with clinical diagnoses only, did not differ with regard to race, anaphylactic triggers or the clinical variables of lung and heart disease. Annual death rate for anaphylaxis in Florida was 5.02/10 000 000. The relative risk of death from anaphylaxis was 14.09 for individuals ≥65 years old ( P = 0.0000002) and 6.38 for individuals 35–64 years old ( P = 0.0019) compared with those who were 5–14 years of age. Deaths among Florida residents that occurred in emergency rooms or outpatient settings were 2.11 times as likely to be anaphylactic deaths than deaths that occurred in inpatient settings ( P = 0.0026). The ratios of anaphylactic deaths to total deaths in March and April and in July and August were greater than the ratios for the other bimonthly periods ( P = 0.02). Conclusion: Death from anaphylaxis in Florida was more likely to occur in older individuals, in an emergency department, and in the months of March and April and July and August.
An evidence-based consensus statement on the role and application of endosonography in clinical practice
Authors: F. Maluf-Filho, C. Dotti, B. Halwan, A. Queiros, C. Kupski, D. Chaves, F. Nakao, A. Kumar
Journal: Endoscopy (2009)

See also: Commentaire de travail de F. Maluf-Filho et al., pp. 979Endoscopy 2009; 41(11): 1009-1009DOI: 10.1055/s-0032-1306758
Populations at risk: addressing health effects due to complex mixtures with a focus on respiratory effects.
Authors: M D Lebowitz
Journal: Environmental Health Perspectives (1991)

Some individuals in the population may be sensitive or susceptible be to the effects of air pollutants. Such sensitivity may be to specific pollutants or classes of pollutants. However, sensitivity or susceptibility in some individuals can be to all irritants, but the sensitivity is likely to be response specific or organ specific. The U.S. Clean Air Act specifically recognizes that some individuals in the population are sensitive to air pollutants and indicates that such individuals need to be protected by air quality standards. It is usually difficult to determine the cause of sensitivity, though various biological mechanisms have been studied. Biological age may be a factor, with the young being most sensitive and susceptible to being affected. An example is the heightened bronchial lability and responsiveness in the very young that appears to disappear with growth. Susceptibility may be innate (e.g., genetic) and/or induced by events/exposures. Frequently, those with preexisting illnesses are part of the sensitive population because they may often respond, sometimes hyperrespond, to a pollutant exposure that may not affect most people. Asthmatics are excellent examples of individuals who were susceptible to the disease and, once inflicted, are susceptible to the effects of many environmental and nonenvironmental agents. Usually only a fraction of the general population will respond with heightened reactions at lower doses. Such individuals require special evaluation and attention in all exposure-response studies and risk assessments. Thus, the conditions defining populations at risk and the methodologies to discover and study them can be reviewed.
The Arc of the Pulmonary Artery Catheter
Authors: Robert A. Fowler
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Calibration of the Direct Ballistocardiogram
Authors: T. J. REEVES, KATHRYN WILLIS, EARNEST BOOTH, HASKELL ELLISON
Journal: Circulation (1953)

A simple method of calibrating the amplitude of the direct ballistocardiogram, utilizing a standard external force to the body, is described. Such a method tends to neutralize many of the variables in apparatus alignment and sensitivity, and provides a basis for comparison of amplitudes in the same and different subjects. Normals of different age groups were studied and the contrast with abnormals with known cardiovascular disease is shown.
Post-vaccinial Encephalitis
Authors: G. D. S. Briggs
Journal: BMJ (1942)

Post-vaccinial EncephalitisIt is thought that the following two cases may be of interest, especially outside the Servtces, where mass vaccinations are not usual and the possibility of post-vaccinial encephalitis does not readily suggest itself.Of 380 vaccinations performed on a batch of recruits, using the one-scarification method, 220 were successful, with the production of one vesicle, and 160 were failures.It is not known how many of the batch had been vaccinated previously.The two patients were admitted to sick- quarters the same morning.Both had been vaccinated 10 days before; neither had been vaccinated previously, and they were billeted in the same room.Case 1.-Aged 34.This man had not felt well at tea-time the previous day and went to bed irnmediately after tea, com- plaining of malaise, shivering, and headache.During the night he felt worse.He was stiff all over, particularly in his arms and legs, and he vomited several times.He was admitted to sick-quarters early next morning.On admission his tempera- ture was 100.6°, pulse 96, and respirations 20; he was moaning and crying out in a hysterical manner, but was conscious and able to answer questions readily.Soon after admission he became much quieter.The pupils reacted normally to light and accommodation, there was no neck rigidity, Babinski's and Kernig's signs and plantar response were doubtful, and all
Exercise responses in patients treated for pulmonary tuberculosis by thoracoplasty.
Authors: M S Phillips, W J Kinnear, D Shaw, J M Shneerson
Journal: Thorax (1989)

Twenty eight subjects (mean age 64 years) who had been treated for tuberculosis by thoracoplasty in the past performed an increasing work rate exercise test, from which maximum oxygen consumption (VO2max), ventilation and heart rate were measured. VO2max was significantly lower than predicted, being 0.75 l/min in 17 subjects, 1.0 l/min in 10, and 1.5 l/min in one. Only one subject achieved a heart rate of 85% of the predicted maximum. The ratio of heart rate to oxygen consumption (HR/VO2) and heart rate at standard interpolated submaximal levels of oxygen uptake at 0.75 l/min (heart rate 0.75) and 1.0 l/min (heart rate 1.0) were normal. VO2max correlated with ventilation at maximal exercise (VE max) (r = 0.87) and FEV1 (r = 0.47). It did not correlate with resting arterial oxygen or carbon dioxide tensions, FEV1, maximum inspiratory pressure, angle of scoliosis, or number of ribs resected. The relation between ventilation and oxygen consumption (VE/VO2) and VE at the submaximal levels of oxygen consumption of 0.75 l/min (VE 0.75) and 1.0 l/min (VE 1.0) were normal. In 10 subjects a plateau of breathing frequency (fmax) was reached, after which the increase in ventilation was achieved by a further increase in tidal volume (VT). These subjects showed significantly lower values for the forced expiratory ratio, VO2max, and VEmax than those with a normal relation between tidal volume and breathing frequency. VEmax was correlated with FEV1 (r = 0.61), FVC (r = 0.46), maximum VT (r = 0.55), change in VT (r = 0.52), fmax (r = 0.56), and change in breathing frequency (r = 0.72). These results indicate that exercise in patients treated for tuberculosis by thoracoplasty is limited by ventilatory capacity and that this is due to a reduction in both dynamic lung volumes and respiratory frequency.
Psoralen and Photoactivation
Authors: LEWIS M. DUBROFF
Journal: Annals of Internal Medicine (1980)

Letters1 March 1980Psoralen and PhotoactivationLEWIS M. DUBROFF, M.D., PH.D.LEWIS M. DUBROFF, M.D., PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-92-3-439_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The valuable article by Perlman and colleagues, "Photochemotherapy and Psoriatic Arthritis: A Prospective Study" (1), successfully shows that nonspondylitic psoriatic arthritis improves with photochemotherapy. From use of 8-methoxypsoralen and long-wave ultraviolet-A light (PUVA), they conclude that PUVA induces an articular response by improving the psoriasis alone: "Since ultraviolet-A light penetrates only to the dermal layer . . . PUVA therapy presumably has no direct anti-inflammatory effect on joints." The data, however, do not allow such a firm conclusion because a group of patients receiving only 8-methoxypsoralen in the absense of light was not included in the study....References1. PERLMANGERBERROBERTSNIGRABARTH SLRTW. Photochemotherapy and psoriatic arthritis: a prospective study. Ann Intern Med. 1979;91:717-22. LinkGoogle Scholar2. DALL 'ACQUAVEDALDIBORDINRODIGHIERO FDFG. New studies on the interaction between 8-methoxypsoralen and DNA in vitro. J Invest Dermatol. 1979;73:191-7. CrossrefMedlineGoogle Scholar3. STERNTHIBODEAUKLEINERMANPARRISHFITZPATRICK RLRJT. Risk of cutaneous carcinoma in patients treated with oral methoxsalen photochemotherapy for psoriasis. N Engl J Med. 1979;300:809-13. CrossrefMedlineGoogle Scholar1. PERLMANGERBERROBERTSNIGRABARTH SLRTW. Photochemotherapy and psoriatic arthritis: a prospective study. Ann Intern Med. 1979;91:717-22. LinkGoogle Scholar2. DALL 'ACQUAVEDALDIBORDINRODIGHIERO FDFG. New studies on the interaction between 8-methoxypsoralen and DNA in vitro. J Invest Dermatol. 1979;73:191-7. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1980Volume 92, Issue 3Page: 439-440KeywordsProspective studiesPsoralen UV APsoriasisPsoriatic arthritis Issue Published: 1 March 1980 PDF downloadLoading ...
Concerted action of various angiogenic factors during acute myocardial infarction in patients: The three lines of defense
Authors: Konstantinos I. Kapetanios, Christos E. Pitsavos, Stamatis Kastelanos, Grigorios P. Vyssoulis, Demosthenes B. Panagiotakos, Emanuel V. Economou, Marina G. Toutouza, Christodoulos Stefanadis, Pavlos K. Toutouzas
Journal: Journal of the American College of Cardiology (2003)
THE GRADIENT OF PERMEABILITY OF THE SKIN VESSELS AS INFLUENCED BY HEAT, COLD, AND LIGHT
Authors: Stephen Hudack, Philip D. McMaster
Journal: The Journal of Experimental Medicine (1932)

The mounting gradient of permeability along the small vessels of the corium is essentially unaltered by active hyperemia produced by heat, cold, or light. Only when the vascular walls are so damaged that rapid leakage ensues, as shown by the development of edema, does the permeability of the capillary web as a whole approximate that of the venules. It is plain that the normal gradient of vascular permeability depends upon the integrity of the vessel wall. The method of experiment described can be utilized for a study of the functional changes which result in the lesions due to burning and freezing.
Experience with the Use of Chlorpromazine and Reserpine in Psychiatry
Authors: George W. Brooks
Journal: New England Journal of Medicine (1956)

THE introduction of the tranquilizing or ataraxic drugs in the treatment of mental illness during 1954 resulted in widespread research in the use of these agents and numerous publications of the findings. Varying results have been obtained, and diverse programs for administration have been suggested. Despite differences in dosage ranges and duration of therapies, most practitioners who have used the ataraxics recognize their role in providing symptomatic relief in many types of psychiatric disorders and in facilitating the introduction of adjunctive therapies and the management of patients. Some practitioners believe that the drugs have brought about or helped bring about . . .
The Prognostic Implications of Plasma Renin in Essential Hypertension
Authors: Norman M. Kaplan
Journal: JAMA (1975)

IN 1972, the hypothesis was proposed that the chances of the major vascular complications of essential hypertension, myocardial infarction and stroke, developing in patients were directly related to the renin status of these patients.<sup>1</sup>The basis for this thesis was the absence of such vascular complications over a ten-year interval among 59 of 219 hypertensive patients who had low plasma renin levels, compared to an incidence of such vascular disease in 11% of 124 patients with normal levels of renin whose mean blood pressures when not receiving therapy were identical. The authors do not claim that a low renin state promises immortality, and they have witnessed vascular complications "in a small proportion" of their group with low levels of renin,<sup>2</sup>but they have repeatedly presented their data as proof of their thesis that low renin levels protect against heart attacks and strokes.<sup>1-5</sup>Moreover, two broad implications have been
The effect of multivalent Sonic hedgehog on differentiation of human embryonic stem cells into dopaminergic and GABAergic neurons
Authors: Tandis Vazin, Randolph S. Ashton, Anthony Conway, Nikhil A. Rode, Susan M. Lee, Verenice Bravo, Kevin E. Healy, Ravi S. Kane, David V. Schaffer
Journal: Biomaterials (2013)
Azithromycin in Patients With Cystic Fibrosis Chronically Infected With Pseudomonas aeruginosa
Authors: Lisa Saiman, Bruce C. Marshall, Nicole Mayer-Hamblett, Jane L. Burns, Alexandra L. Quittner, Debra A. Cibene, Sarah Coquillette, Ann Yunker Fieberg, Frank J. Accurso, Preston W. Campbell III, None for the Macrolide Study Group
Journal: JAMA (2003)

ContextTreatment strategies for cystic fibrosis (CF) lung disease include antibiotics, mucolytics, and anti-inflammatory therapies. Increasing evidence suggests that macrolide antibiotics might be beneficial in patients with CF.ObjectiveTo determine if an association between azithromycin use and pulmonary function exists in patients with CF.Design and SettingA multicenter, randomized, double-blind, placebo-controlled trial conducted from December 15, 2000, to May 2, 2002, at 23 CF care centers in the United States.ParticipantsOf the 251 screened participants with a diagnosis of CF, 185 (74%) were randomized. Eligibility criteria included age 6 years or older, infection with Pseudomonas aeruginosa for 1 or more years, and a forced expiratory volume in 1 second (FEV1) of 30% or more. Participants were stratified by FEV1 (≥60% predicted vs &lt;60% predicted), weight of less than 40 kg vs 40 kg or more, and CF center.InterventionThe active group (n = 87) received 250 mg (weight &lt;40 kg) or 500 mg (weight ≥40 kg) of oral azithromycin 3 days a week for 168 days; placebo group (n = 98) received identically packaged tablets.Main Outcome MeasuresChange in FEV1 from day 0 to completion of therapy at day 168 and determination of safety. Secondary outcomes included pulmonary exacerbations and weight gain.ResultsThe azithromycin group had a mean 0.097-L (SD, 0.26) increase in FEV1 at day 168 compared with 0.003 L (SD, 0.23) in the placebo group (mean difference, 0.094 L; 95% confidence interval [CI], 0.023-0.165; P = .009). Nausea occurred in 17% more participatns in the azithromycin group (P = .01), diarrhea in 15% more (P = .009), and wheezing in 13% more (P = .007). Participants in the azithromycin group had less risk of experiencing an exacerbation than participants in the placebo group (hazard ratio, 0.65; 95% CI, 0.44-0.95; P = .03) and weighed at the end of the study an average 0.7 kg more than participants receiving placebo (95% CI, 0.1-1.4 kg; P = .02).ConclusionAzithromycin treatment was associated with improvement in clinically relevant end points and should be considered for patients with CF who are 6 years or older and chronically infected with P aeruginosa.
School screening for scoliosis: cohort study of clinical course.
Authors: R A Dickson, P Stamper, A M Sharp, P Harker
Journal: BMJ (1980)

A visual examination of 1764 Oxford schoolchildren for scoliosis was followed by low-dose radiography of the spine in those who showed evidence of asymmetric body topography; radiography was repeated a year later to assess progression. Forty-four children had curves of 10 degrees or more. Two had a congenital abnormality and the remaining 42 were classified according to the type of curve: sacral tilt (compensatory), spinal (idiopathic), or combined (sacral tilt and spinal). Progression occurred in 6 (14%) children, none of whom had only a sacral tilt. These results suggest that only by measuring sacral tilt can benign compensatory curves be differentiated from true idiopathic scoliosis.
Risks of Needle Biopsy of the Liver
Authors: R. Terry
Journal: BMJ (1952)

_~~~~~~~~~~~MIA JORA will therefore end in complete refractoriness, at which stage only free folic acid will produce haematological benefit.Without doubt, however, other unknown factors are in- volved, for folic acid is not always completely successful in curing the anaemia.Whatever the explanation, the beneficial clinical, nutri- tional, and haematological effect of folic acid in idiopathic steatorrhoea accompanied by megaloblastic anaemia makes accurate diagnosis a matter of great importance.It is all too easy, if anaemia is macrocytic and megaloblastic and associated with a histamine-fast achlorhydria, to diagnose Addisonian pernicious anaemia.In all such cases a careful assessment of the initial effect of parenteral liver extract or vitamin Bi is necessary, and, if not classical, a fat-balance test should be the next investigation irrespective of the gross appearance of the stools or a history of intestinal dysfunc- tion.A positive result from this somewhat laborious pro- cedure is an indication for vitamin B12 or liver to give place to folic acid. SununarySeven cases diagnosed as Addisonian pernicious anaemia before the age of 30, in the period 1937-49, were reinvestigated during 1950.Alimentary symptoms were insignificant, but in three patients the initial response to parenteral liver was suboptimal.The diagnosis was confirmed in three patients ; but four, including all three who responded poorly to liver in the beginning, were proved to be suffering from idiopathic steatorrhoea.These latter cases are described in detail, and their differentiation from Addisonian pernicious anaemia is discussed.Various clinical, haematological, biochemical, and radiological features were suggestive of steatorrhoea; the demonstration of defective fat absorption was con- clusive.No evidence of deficiency of the fat-soluble vitamins D and K was found.The therapeutic importance of accurate diagnosis of occult steatorrhoea is stressed.I wish to thank Professor Sir John McNee, in whose wards the patients were investigated and treated, for much encouragement and helpful
Prenatal Diagnosis of Ornithine Transcarbamylase Deficiency with Use of DNA Polymorphisms
Authors: Joyce Fox, Adelle M. Hack, Wayne A. Fenton, Mitchell S. Golbus, Susan Winter, Frantisek Kalousek, Rima Rozen, Saul W. Brusilow, Leon E. Rosenberg
Journal: New England Journal of Medicine (1986)

ORNITHINE transcarbamylase is a hepatic urea-cycle enzyme that is required for the detoxification of ammonia and the biosynthesis of urea.1 Human ornithine transcarbamylase deficiency, an X-linked disorder,2 , 3 results in severe and often fatal neonatal ammonia intoxication in hemizygous affected males. The neurologic outcome in affected boys who survive the neonatal period is poor; they have a high incidence of mental retardation, cerebral palsy, and seizure disorders.4 Prenatal diagnosis of ornithine transcarbamylase deficiency has been difficult because the enzyme is not expressed in amniocytes and because no metabolic products of this disorder have been detected in amniotic fluid. Prenatal diagnosis by . . .