tbuckley/cabot-search huggingface dataset:
Prevention of Lactic Acidemia with Redox Dyes.
Authors: W. E. Huckabee
Journal: Annals of Internal Medicine (1963)

s1 April 1963Prevention of Lactic Acidemia with Redox Dyes.W. E. Huckabee, M.D., W. A. Neill, M.D.W. E. Huckabee, M.D.Search for more papers by this author, W. A. Neill, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-4-712_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPatients with lactic acidosis, previously observed, died within days of onset of the disease and were little helped by alkali therapy. A very high proportion of "excess lactate" in the blood of these patients suggested the basis to be tissue hypoxia, but the cause of the hypoxia is not known; neither hypoxemia nor circulatory failure was present. Attempts were made to determine the protective efficacy against experimental excess lactatemias of substances known to facilitate mitochondrial electron transport and permit tissue oxidations to occur at very low PO2. Two of these were effective in anesthetized dogs, methylene blue and new methylene... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston Mass. (CI) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByLactic acidosisSignificance of blood lactate elevations among patients with acute leukemia and other neoplastic proliferative disorders 1 April 1963Volume 58, Issue 4Page: 712-712KeywordsBloodHypoxiaLactatesLactic acidLactic acidosisMethylene bluePartial pressure of oxygen Issue Published: 1 April 1963 PDF DownloadLoading ...
RANTES Promoter Genotype Is Associated With Diabetic Nephropathy in Type 2 Diabetic Subjects
Authors: Kunihiro Nakajima, Yasushi Tanaka, Takashi Nomiyama, Takeshi Ogihara, Fuki Ikeda, Rei Kanno, Noseki Iwashita, Ken Sakai, Hirotaka Watada, Tomio Onuma, Ryuzo Kawamori
Journal: Diabetes Care (2003)

To evaluate the effect of RANTES gene promoter polymorphism and RANTES receptor (CCR5 gene) promoter polymorphism on diabetic nephropathy in Japanese type 2 diabetic subjects.A total 616 Japanese subjects with type 2 diabetes were recruited. Polymorphisms of -28 C/G and -403 G/A in the RANTES gene promoter region, and of 59029 G/A in the CCR5 gene promoter region were detected by PCR-RFLP (restriction fragment length polymorphism). The association of these genotypes with nephropathy was analyzed.While the RANTES -403 genotype showed no association with nephropathy, the frequency of the -28G allele was significantly higher in the DN2 group (urinary albuminuria-to-creatinine ratio [ACR] >or=300 mg/g creatinine, serum creatinine <2.0 mg/dl) than in the DN0 (ACR <30 mg/g creatinine) and DN1 (ACR >or=30 mg/g creatinine and <300 mg/g creatinine) groups. The frequency of a RANTES -28G-positive genotype (C/G or G/G) was higher in the DN2 group than in the DN0 and DN1 groups (34% vs. 25 and 20%, P = 0.0268, chi(2) = 4.905), and the frequency of a CCR5 59029 A-positive genotype (G/A or A/A) was higher in the DN1 and DN2 groups than in the DN0 group (84 and 85% vs. 76%, P = 0.0123, chi(2) = 6.269). Discriminant analysis showed that the RANTES -28G-positive genotype and CCR5 59029A-positive genotype were independently associated with nephropathy. The percentage of macroalbuminuria was twofold higher in the subjects having -28G or 59029A and threefold higher in the subjects having -28G and 59029A than in the subjects without -28G and 59029A.The RANTES promoter -28G genotype and CCR5 promoter 59029A genotype may be independent risk factors for diabetic nephropathy in patients with type 2 diabetes and may have an additive effect on nephropathy.
Abstract P2-11-17: Pilot Study to Evaluate a Home-based Exercise and Weight Loss Intervention on Cardiopulmonary Fitness and Markers of Breast Cancer Risk in Postmenopausal Breast Cancer Survivors
Authors: D Burnett, JR Klemp, C Porter, KJ Schmitz, CJ Fabian, P Kluding
Journal: Cancer Research (2012)

Abstract Background: BrCa survivors have an estimated 4-fold increase in risk for developing cardiovascular disease compared to women never treated for breast cancer and a nearly 3-fold increase in breast cancer mortality in women with an exercise capacity (VO2max) less than 28mL kg−1 min−1. Cardiac events are the second most common cause of death in long-term breast cancer (BrCa) survivors. Purpose: We conducted a study to investigate the effects of standard exercise or structured exercise on targeted cardiovascular outcomes during a home-based diet and exercise intervention for breast cancer survivors. Method: Cross-sectional within- and between-group design. A total of 19 breast cancer survivors, average age of 52.6+/−9.3, were enrolled in the study. A convenient sample was enrolled into two exercise groups receiving either: standard (150 minutes per week of usual care (exercise without instruction) cardiovascular exercise + resistance training) or structured (150 minutes per week of gradual increased intensity cardiovascular exercise + resistance training) exercise instruction along with a group based behavioral weight loss intervention. All participants underwent baseline and 17 week assessments including maximal exercise testing (VO2max and minutes on the treadmill), measurements of body composition (weight, BMI, % body fat), and assessment of quality of life. Results: We report on the 16 participants who completed the baseline and 17 week assessments (9 = Standard Exercise Group; 7 = Structured Exercise Group). The structured exercise group exhibited significantly greater improvements in measures of cardiorespiratory fitness: VO2max (p = 0.05) and duration on treadmill (p = 0.02). No significant differences were noted for all other cardiorespiratory fitness testing outcomes. Significant improvements from baseline to 17 weeks were seen across both groups for all measures of body composition. Lean body mass did not significantly change from baseline to 17 weeks in both groups. There were no significant between group differences for change in body composition. Conclusion: In this study, both standard exercise and structured exercise improved CR fitness measured by VO2max, but the structured exercise group experienced significantly greater improvements. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P2-11-17.
Cyclosporin A for the treatment of aplastic anemia refractory to antithymocyte globulin
Authors: Ronald Bridges, Graham Pineo, Walter Blahey
Journal: American Journal of Hematology (1987)

Abstract Antithymocyte globulin (ATG) is an established form of therapy for severe aplastic anemia (SAA). However, in patients who do not respond to this treatment and who are not candidates for bone marrow transplantation few successful therapeutic alternatives exist. We report two such patients who have shown a therapeutic response to Cyclosporin A (CSA) (Sandimmune, Sandoz). Case 1, a 15 year old male, and Case 2, a 34 year old female, were diagnosed as having SAA in September 1984 and May 1984 respectively. Treatment with high dose Methylprednisolone (MPN) and ATG in Case 1 and MPN, ATG and Oxymetholone in Case 2 for ten days was ineffective in both cases. Case 1 developed anaphylaxis with both repeat ATG and ALG (antilymphoblast globulin), and Case 2 failed to respond to repeat ATG. Both required frequent packed cells and platelet transfusions. At five and six months respectively following completion of ATG therapy, CSA was started at 10 mg/kg/day in divided doses orally. Renal and liver functions and CSA blood levels were followed. Within six weeks both patients exhibited a hematologic response and were no longer transfusion dependent. On maintenance therapy of 4 mg/kg/day (Case 1) and four months after discontinuing CSA (Case 2) the hematologic values are as follows: hemoglobin 160 and 130 g/L, absolute granulocyte count 3100 and 1640 × 10 9 /L, and platelets 132 and 84 × 10 9 /L respectively. Side effects included hypertrichosis, gingival hyperplasia and mild reversible nephrotoxicity. CSA appears to represent an effective form of therapy for patients with SAA refractory to ATG.
PREDICTORS AND CLINICAL IMPLICATIONS OF MINIMAL ST-SEGMENT ELEVATION IN PATIENTS WITH ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION
Authors: Se Yong Jang, Won Suk Choi, Myung Hwan Bae, Jang Hoon Lee, Dong Heon Yang, Hun Sik Park, Yongkeun Cho, Shung Chull Chae
Journal: Journal of the American College of Cardiology (2014)
Rationale for co-targeting IGF-1R and ALK in ALK fusion–positive lung cancer
Authors: Christine M Lovly, Nerina T McDonald, Heidi Chen, Sandra Ortiz-Cuaran, Lukas C Heukamp, Yingjun Yan, Alexandra Florin, Luka Ozretić, Diana Lim, Lu Wang, Zhao Chen, Xi Chen, Pengcheng Lu, Paul K Paik, Ronglai Shen, Hailing Jin, Reinhard Buettner, Sascha Ansén, Sven Perner, Michael Brockmann, Marc Bos, Jürgen Wolf, Masyar Gardizi, Gavin M Wright, Benjamin Solomon, Prudence A Russell, Toni-Maree Rogers, Yoshiyuki Suehara, Monica Red-Brewer, Rudy Tieu, Elisa de Stanchina, Qingguo Wang, Zhongming Zhao, David H Johnson, Leora Horn, Kwok-Kin Wong, Roman K Thomas, Marc Ladanyi, William Pao
Journal: Nature Medicine (2014)
Region-specific, pacing-induced changes in repolarization in rabbit atrium: An example of sensitivity to the rare
Authors: E SOSUNOV, E ANYUKHOVSKY, D HEFER, T ROSEN, P DANILOJR, M JANSE, M ROSEN
Journal: Cardiovascular Research (2005)

In subsets of patients paroxysmal firing of ectopic foci in pulmonary veins or coronary sinus is an important cause of atrial fibrillation. This appears to represent a rare event overriding a dominant sinus mechanism to alter the rhythmic firing of the atrium. Hence, we tested the hypothesis that a rare stimulation pattern might alter the myocardial substrate, making it more susceptible to the initiation of arrhythmias.In isolated right and left rabbit atria, a "rare" burst pacing protocol (BPP) was applied as follows: over 3 h, preparations were driven for 4.5 min from sinus node (SN) or Bachmann's bundle (BB) regions at cycle length (CL)=400 ms followed by 30 s of stimulation from coronary sinus (CS) or pulmonary vein (PV) at CL=200 ms. Microelectrodes were used to record action potentials at the end of 4.5 min of pacing at CL=400 ms. We then intervened with 5-min bigeminal pacing to probe atrial vulnerability to arrhythmias: S1 was delivered from SN or BB and S2 from CS or PV, respectively. S1-S2 interval was the shortest eliciting a propagated response.BPP shortened repolarization in CS and PV regions but not in SN or BB, resulting in increased dispersion of repolarization in right and decreased in left atria. Propranolol, atropine and losartan failed to alter the decrease in repolarization induced by BPP whereas apamin, nifedipine and ryanodine prevented BPP effects. Before BPP, bigeminy did not induce arrhythmias in either atrium, but after BPP, bigeminy significantly increased the incidence of arrhythmias in the right atrium.BPP from foci outside the regions of dominant activation alters dispersion of atrial repolarization. Modulation of apamin-sensitive channels may contribute to the shortening of repolarization in CS and PV regions. Alterations of atrial repolarization gradient create an arrhythmogenic substrate and may be an early step in atrial electrophysiologic remodeling.
Catheter Ablation of Arrhythmias
Authors: MARK E. JOSEPHSON
Journal: Annals of Internal Medicine (1984)

The ability to localize the sites of origin of arrhythmias or those sites critical to their maintenance or their life-threatening consequences has provided the potential for ablating these arrhythmias by delivering shocks through catheters at these critical sites. The capability of treating various arrhythmias by the delivery of shocks through catheters placed at specific intracardiac sites is being studied. These techniques are being evaluated for the creation of atrioventricular blocks to control the ventricular response during supraventricular arrhythmias and for the ablation of bypass tracts and foci of ventricular tachycardia. Complications, including cardiac rupture, and variable success rates make it imperative that such studies only be done by well-trained electrophysiologists. As current techniques evolve, catheter ablation may prove to be a reasonable alternative to pharmacologic or surgical management of patients with disabling arrhythmias.
p90RSK2 is essential for FLT3-ITD– but dispensable for BCR-ABL–induced myeloid leukemia
Authors: Shannon Elf, Dean Blevins, Lingtao Jin, Tae-Wook Chung, Ifor R. Williams, Benjamin H. Lee, Jian-Xin Lin, Warren J. Leonard, Jack Taunton, Hanna J. Khoury, Sumin Kang
Journal: Blood (2011)
Response to Costa
Authors: Yau-Jiunn Lee, Jack C.-R. Tsai
Journal: Diabetes Care (2002)

I am very grateful to Costa et al. (1) for their letter in this issue of Diabetes Care , because their findings give me the opportunity to clarify several important points. Our recent paper (2) associated ACE gene insertion/deletion (I/D) polymorphism with metabolic syndrome (MS) in Chinese type 2 diabetic patients. Although Costa et al. showed a similar prevalence of MS in Brazilian type 2 diabetic patients, they did not find any association between ACE gene I/D polymorphism and MS. While we believe their findings are interesting, we do not believe that they can be used to support their claim that our findings came about by chance. The prevalence of MS in patients with type 2 diabetes among different ethnic populations could not be evaluated and compared until MS was defined by the World Health …
Lactating mothers infected with Ebola virus: EBOV RT-PCR of blood only may be insufficient
Authors: M Moreau, C Spencer, J G Gozalbes, R Colebunders, A Lefevre, S Gryseels, B Borremans, S Gunther, D Becker, J A Bore, F R Koundouno, A Di Caro, R Wölfel, T Decroo, M Van Herp, L Peetermans, A M Camara
Journal: Eurosurveillance (2015)

Binary file ES_Abstracts_Final_ECDC.txt matches
The E7 Protein of Cutaneous Human Papillomavirus Type 8 Causes Invasion of Human Keratinocytes into the Dermis in Organotypic Cultures of Skin
Authors: Baki Akgül, Ramón García-Escudero, Lucy Ghali, Herbert J. Pfister, Pawel G. Fuchs, Harshad Navsaria, Alan Storey
Journal: Cancer Research (2005)

Abstract Human papillomaviruses (HPV) have been implicated in the development of nonmelanoma skin cancer (NMSC). The molecular mechanisms by which these viruses contribute towards NMSC are poorly understood. We have used an in vitro skin-equivalent model generated by transducing primary adult human epidermal keratinocytes with retroviruses expressing HPV genes to investigate the mechanisms of viral transformation. In this model, keratinocytes expressing HPV genes are seeded onto a mesenchyme composed of deepidermalized human dermis that had been repopulated with primary dermal fibroblasts. Expression of the HPV8 E7 gene caused both an enhancement of terminal differentiation and hyperproliferation, but most strikingly, the acquisition of the ability to migrate and invade through the underlying dermis. The basement membrane integrity was disrupted in a time-dependent manner in areas of invading keratinocytes, as evidenced by immunostaining of its protein components collagen types VII, IV, and laminin 5. This was accompanied by the overexpression of extracellular matrix metalloproteinases MMP-1, MMP-8, and MT-1-MMP. These results suggest that the cutaneous HPV type 8 that is frequently found in NMSC of epidermodysplasia verruciformis patients may actively promote an invasive keratinocyte phenotype. These findings also highlight the importance of epithelial-extracellular matrix-mesenchymal interactions that are required to support cell invasion.
TCT-96 Safety and Early Efficacy of the Lariat Procedure: Results from the U.S. Left Atrial Appendage Ligation Consortium
Authors: Matthew J. Price, J.D. Burkhardt, Luigi Di Biase, Jeffrey Goldstein, Bradley P. Knight, Albert C. Lin, Andrea Natale, Taral K. Patel, Ashish Pershad, Steven Yakubov
Journal: Journal of the American College of Cardiology (2013)
Atopic eczema in monozygotic twins with Dubowitz syndrome
Authors: None MOhrenschlager, None Beham, None Abeck, None Ring
Journal: British Journal of Dermatology (1998)

Journal Article Atopic eczema in monozygotic twins with Dubowitz syndrome Get access MÖhrenschlager, MÖhrenschlager Department of Dermatology and Allergy, Biederstein, Technical University of Munich, D‐80802 Munich, Germany Search for other works by this author on: Oxford Academic Google Scholar Beham, Beham Department of Dermatology and Allergy, Biederstein, Technical University of Munich, D‐80802 Munich, Germany Search for other works by this author on: Oxford Academic Google Scholar Abeck, Abeck Department of Dermatology and Allergy, Biederstein, Technical University of Munich, D‐80802 Munich, Germany Search for other works by this author on: Oxford Academic Google Scholar Ring Ring Department of Dermatology and Allergy, Biederstein, Technical University of Munich, D‐80802 Munich, Germany Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 138, Issue 6, 1 June 1998, Pages 1091–1092, https://doi.org/10.1046/j.1365-2133.1998.02288.x Published: 01 June 1998
GASTROSTOMY—PRESENTATION OF ILLUSTRATIVE CASE.
Authors: J. A. BAUGHMAN
Journal: JAMA (1898)

Mrs. R. E., 20 years of age, in August, 1895, swallowed an indefinite quantity of a solution of potassium hydrate, commonly known as concentrated lye, of uncertain strength. Whether any of the chemical reached the stomach is not known, but its escharotic effect was markedly exerted in the esophagus. I did not see the case for some weeks after the accident and am unable to say what, if any, constitutional effects the drug produced. The attending physician treated the case by quieting pain, giving demulcent drinks and liquid food. No attempt was made to preserve the lumen of the esophagus by the systematic passage of bougies during the time cicatricial contraction was taking place. While such a procedure is advocated in many of our text-books it is of doubtful utility; for gradually and persistently stenosis and atresia succeed each other. In December, 1895 the case was referred to me, as
Differential effect of cyclosporin A on activation signaling in human T cell lines.
Authors: B Manger, K J Hardy, A Weiss, J D Stobo
Journal: Journal of Clinical Investigation (1986)

Different T cell lines, which can be induced to secrete interleukin 2 (IL-2) in vitro, were used to dissect the effect of cyclosporin A (CsA). The T leukemia cell Jurkat requires an increase in cytoplasmic calcium concentration ([Ca++]i) and phorbol myristate acetate (PMA) for the induction of IL-2 production, which is completely blocked by CsA. Another T cell line, HUT 78, also produces IL-2 in response to a rise in [Ca++]i and PMA; however, in HUT 78, PMA alone induces low levels of IL-2 production that is not blocked by CsA. After treatment with 5-azacytidine, HUT 78 cells produced maximal levels of IL-2 in response to PMA alone without requiring [Ca++]i increasing stimuli. In these cells no inhibitory effect of CsA on PMA-induced activation could be demonstrated. In addition, CsA does not inhibit PMA-induced translocation of protein kinase C. These data suggest that CsA does not globally inhibit IL-2 gene expression, but rather interferes with signaling events of T cell activation.
Prognostic Significance of FDG PET/CT on the Follow-up of Patients of Differentiated Thyroid Carcinoma With Negative I131 Whole- Body Scan and Elevated Thyroglobulin Levels
Authors: Carol S. Marcus
Journal: Clinical Nuclear Medicine (2013)

David Geffen School of Medicine at UCLA Los Angeles, CA [email protected] Conflicts of interest and sources of funding: none declared.
1029. Integrin and Serotype 3 Receptor-Targeted Virotherapy Using a Telomerase-Selective Oncolytic Adenovirus
Authors: Yosuke Kawakami, Angel A. Rivera, Minghui Wang, Dirk M. Nettelbeck, Mariam A. Stoff-Khalili, Mack N. Barnes, Gene P. Siegal, Ronald D. Alvarez, David T. Curiel
Journal: Molecular Therapy (2005)

Conditionally replicative adenovirus (CRAd) is a cervical cancer gene therapy strategy which seeks to achieve selective viral replication in tumor cells. Oncolysis of infected cells creates a |[ldquo]|bystander effect|[rdquo]|, leading to infection of neighboring cancer cells with progeny virus. However, cervical cancer cells are relatively resistant to infection by adenovirus (Ad), thus limiting the capability of CRAd agents to achieve effective lateralization within the tumor. The objective of this proposal was to establish an efficient and selective infectivity-enhanced CRAd-based therapeutic modality for cervical cancer. We have developed methods to dramatically improve the ability of Ad to infect cervical cancer cells by replacing the knob region of Ad serotype 5 fiber with Ad serotype 3 knob (Ad5/3 chimera) and by putting an Arg-Gly-Asp (RGD)-4C motif in the HI loop of the Ad fiber knob region (RGD modification). Human telomerase reverse transcriptase (hTERT) promoter, which is active in many cancers but mostly inactive in normal organs including the liver, maintains this useful profile in our CRAd construct for cervical cancer. We employed recombinant Ad vectors containing luciferase reporter genes under the control of cytomegalovirus (CMV) promoter with or without fiber mutation (Ad5/3LucRGD and Ad5Luc) to evaluate transductional activity in cervical cancer cell lines in vitro. Then, we evaluated the oncolytic effect of hTERT-CRAd (Ad5/3hTERT E1-RGD and AdhTERT E1) in cervical cancer cell lines by both an MTS assay and crystal violet assay. hTERT-CRAd showed selective oncolysis in hTERT-positive cervical cancer cells but not in the hTERT negative, normal cells. Ad5/3Luc-RGD Ad showed increased reporter gene expression in cervical cancer cell line, HeLa (12.7 times more compare to Ad5Luc in a luciferase assay). Moreover, oncolysis with hTERT-CRAd in cervical cancer cells was much enhanced in Ad5/3RGD retaining the specificity both in a MTS assay and crystal violet assay. These results suggest that infectivity enhancement with mutant fiber is especially effective for enhancing oncolysis. This infectivity-enhanced hTERT-CRAd may thus be useful in the gene therapy of cervical cancer.
[557] HEPATITIS C VIRUS CARRIERS WITH NORMAL ALANINE AMINOTRANSFERASES: ANALYSIS OF FACTORS INVOLVED IN FIBROSIS PROGRESSION
Authors: R. Rapetti, C. Fabris, L. Aguggia, R. Minisini, L. Franchini, R. Mella, P. Toniutto, C. Smirne, C. Colletta, C. Vandelli, M. Pirisi
Journal: Journal of Hepatology (2007)