tbuckley/cabot-search huggingface dataset:
A Leap of Faith in Antidepressant Treatment?
Authors: Barbara Mintzes
Journal: JAMA Psychiatry (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2022 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
META-ANALYSIS OF RANDOMIZED TRIALS COMPARING CULPRIT VESSEL ONLY VERSUS SINGLE-SETTING MULTIVESSEL REVASCULARIZATION DURING PRIMARY PCI
Authors: Partha Sardar, Saurav Chatterjee, Fernando Alfonso, Gary Ledley, Marco A. Magalhaes, Harikrishna Makani, Ron Waksman
Journal: Journal of the American College of Cardiology (2014)
An electron-microscopic study of smooth muscle cell dye coupling in the pig coronary arteries. Role of gap junctions.
Authors: J L Bény, J L Connat
Journal: Circulation Research (1992)

Arterial smooth muscles behave like a syncytium, since they are electrically coupled. It is generally assumed that electrical coupling and dye coupling are mediated by gap junctions. No gap junctions could be detected by transmission electron microscopy in media of coronary arteries. We looked for the presence of gap junction protein in vascular smooth muscle by immunohistochemistry with light microscopy. Immunohistologically detectable connexin is expressed by smooth muscle cells of the media of pig coronary arteries, where staining occurs as a discrete punctation. We investigated the dye coupling in strips of pig coronary artery. The fluorescent dye lucifer yellow was microiontophoretically injected into a smooth muscle cell through an intracellular microelectrode. The dye was visualized on the entire strip, then on semithin sections with a fluorescence microscope, and at the ultrastructural level by using an anti-lucifer yellow antibody revealed by the protein A-gold technique. In all the tissues examined, the cells were dye-coupled. We conclude that in arterial media the smooth muscle cells are dye-coupled, despite the absence of detectable gap junctions by transmission electron microscopy, and suggest that dye coupling could occur via isolated gap junction channels.
Points from Letters: Lupus and Lupus Erythematosus
Authors: C. P. Petch
Journal: BMJ (1970)

Any protection of gas exchange may, therefore, be achieved at the expense of right ventricular work, and this could be undesirable.These views are speculative, but this aspect of the treatment of airways obstruction is more conjecture than fact.In view of this, may I suggest a moratorium on claims by pharmaceutical companies so that more information can be obtained to provide a rational basis for discussion and advice.In conclusion, may I suggest that much of this doubt is peripheral to the main problem.Pressurized aerosols should not be prescribed to be used at the discretion of the patient, but the patient should be told the frequency of self-administration.A Ventolin or Alupent inhaler, for example, can be prescribed with one to two puffs at four-hour intervals as the maximum dose.If the patient requires a more frequent dose the family doctor should be informed and corticosteroids or admission to hospital be considered.It is undertreatment with other remedies rather than overtreatment with catecholamines that is the point most of us fail to appreciate.If the recent work on blood-gas changes draws attention to this more important problem, then a greater benefit may accrue.-Iam, etc.,
Health and human rights in contemporary humanitarian crises: is Kosovo more important than Sierra Leone?
Authors: P. Salama, B. Laurence, M. L Nolan
Journal: BMJ (1999)

In 1998, international agencies operating in Kosovo recognised that human rights violations were causing a humanitarian crisis. The language and principles of human rights were used effectively to advocate interventions that addressed the root causes of the conflict.1 As the details of the tragedy in Kosovo have become clearer, the international community has expressed some sense of vindication that the systematic abuse of human rights justified the military intervention. According to some, the NATO led intervention sets an important precedent: human rights were given priority over the rights of a particular state, a challenge to the notion of the absolute inviolability of state sovereignty.2

This increased priority given to human rights is laudable. However, such rights, universal in scope, should not be differentially recognised; their protection must be extended beyond Europe (press release by Sergio Vieira de Mello, undersecretary-general for humanitarian affairs and emergency relief coordinator, UN Office for the Coordination of Humanitarian Affairs, 12 August 1999). The causal link between human rights violations and a humanitarian crisis must be recognised wherever it exists.3 Addressing the roots of contemporary crises requires a detailed analysis that incorporates a study of human rights, followed by multifaceted solutions supported by sustained international attention. The standard assessment of and response to humanitarian needs effectively mitigates human suffering but has virtually no role in preventing its ongoing generation.4

In this article we draw on our collective experience in Sierra Leone to illustrate some of the links between human rights violations and health effects in that country's chronic conflict.

#### Summary points

Human rights violations have contributed to large scale humanitarian crises in protracted conflicts in Kosovo and Sierra Leone

The politico-military intervention in Kosovo exemplifies a growing international commitment to human rights and the recognition that humanitarian responses alone are often insufficient

Humanitarian responses …
Abstract 4840: Blockade of IL-10 production in effector B cells significantly increases their therapeutic efficacy in cancer adoptive immunotherapy
Authors: Fang Zheng, Qin Pan, Martin Egenti, Alfred E. Chang, Qiao Li
Journal: Cancer Research (2012)

Abstract We have previously reported the antitumor reactivity of adoptively transferred effector B cells and the mechanisms by which they mediate tumor regression in a spontaneous metastasis model. 4T1 breast cancer cells were inoculated into syngeneic Balb/c mice to prime tumor-draining lymph node (TDLN). TDLNs were subsequently harvested and B cells activated ex vivo. When adoptively transferred into mice inoculated with 4T1 tumor in the mammary fat pad, these activated B cells alone mediated the inhibition of spontaneous metastases to the lung. In this study, we used IL-10−/− Balb/c mice to generate IL-10−/− TDLN, and evaluated the antitumor immunity of IL-10−/− TDLN B cells. Adoptively transferred IL-10−/− TDLN B cells mediated significantly more effective antitumor immunity than equal numbers of WT TDLN B cells (p&amp;lt;0.05). Activated IL-10−/− effector 4T1 TDLN B cells were capable of killing 4T1 tumor cells in a tumor antigen specific manner in in vitro cytotoxicity assays independent of antibody and complement. Adoptive transfer of IL-10−/− TDLN B cells resulted in the induction of host T and B cell antitumor immunity significantly more than adoptive transfer of WT TDLN B cells (p&amp;lt;0.05). This was evident by significantly modulated cytokine production (e.g. up-regulated IFN-gamma and IL-2 production by host T cells, but down-regulated IL-10 production by host B cells). In addition, adoptively transferred IL-10−/− TDLN B cells increased the production of IgG which bound to 4T1 tumor cells. Furthermore, IL-10−/− TDLN B cell infusion significantly increased tumor cell lysis (CTL) activity mediated by host B cells as well as T cells in an immunologically specific fashion. The molecular and cellular pathways involved in the direct killing of 4T1 tumor cells by IL-10−/- 4T1 TDLN effector B cells and by host B cells subjected to IL-10−/- 4T1 TDLN effector B cell adoptive transfer is under active investigation in our lab. While the role played by B cells in the host immune response to cancer is complex and controversial, our results indicate that removal of IL-10-producing B cell subsets may represent an effective strategy to augment the therapeutic efficacy of TDLN B cells used in adoptive immunotherapy. Mechanistically, adoptive transfer of B cells depleted of IL-10-producing subsets destroys tumor cells directly and confers greater host cellular and humoral antitumor immunity by shifting cytokine production to a Type 1 profile and by producing tumor-reactive antibodies respectively. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4840. doi:1538-7445.AM2012-4840
Five Cases of Extra-Uterine Pregnancy Operated upon at the Time of Rupture
Authors: L. Tait
Journal: BMJ (1884)

sohema will be then any more productive of real gain.I demand for them, however, a share in the advantages.I also pointed out the danger of private workers in the provinces being swamped by London committees -experto crede.I ran that danger, but was not swamped.Some years ago, I was working at the subject of hydrophobia; for some years, I had been collecting mate- rial, and, fortunately, had my MSS. in order, but not quite ready
Educated Guesses: Making Policy about Medical Screening Tests
Authors: K Kelikowske
Journal: BMJ (1994)

Louise B Russell University of California Press, pp 128 ISBN 0-520-08366-0

Educated Guesses tells us that “can't hurt and might help” are not appropriate reasons for recommending a screening test and then provides a framework for policymakers and practitioners to enable them to understand the complex issues and trade offs entailed in recommending medical screening tests.

Louise Russell discusses screening for three medical conditions - cervical cancer, prostatic cancer, and high serum cholestrol concentration. In selecting these conditions, Russell reminds …
Screening of patients with retinitis pigmentosa for heredopathia atactica polyneuritiformis (Refsum's disease).
Authors: J M Goldman, M E Clemens, F B Gibberd, J D Billimoria
Journal: BMJ (1985)

Endoscopic Teflon injection for a refluxing ureteric stump after simple nephrectomy Persistence of vesicoureteric reflux into adult life is unusual nowadays given the aggressive investigation of childhood urinary tract in- fections.We report a case in which a simple nephrectomy performed for apparent end stage calculous disease of the kidney was complicated by the discovery, postoperatively, that the renal abnormality was due to unrecognised vesicoureteric reflux.be normal.
Cerebrovascular accident in β‐thalassemia major (β‐TM) and β‐thalassemia intermedia (β‐TI)
Authors: Mehran Karimi, Maryam Khanlari, Eliezer A. Rachmilewitz
Journal: American Journal of Hematology (2007)

Abstract Chronic hypercoagulable state expressed clinically by thromboembolic events has been described in thalassemia. One of the affected organs is the brain where symptomatic and asymptomatic damage has been reported. The present report describes seven cases who presented with the signs of cerebrovascular accident (CVA), five ischemic and two with hemorrhage. Two of them died. All patients were splenectomized, five received regular blood transfusions, and their ferritin levels were between 1,200 and 3,000 mg %. In addition, four patients had congestive heart failure and atrial fibrillation, and three had “Bronze diabetes,” The recommendation on the basis of the results is that well‐designed clinical trials are indicated to monitor asymptomatic brain damage by magnetic resonance imaging in splenectomized patients over the age of 20 years, who are not regularly transfused and have a high risk to develop thromboembolic events. In this subset of patients, anticoagulant and/or antiplatelet therapy should be considered. Moreover, treatment of additional complications resulting from iron overload, which may contribute to the etiology of CVA such as cardiac failure and arrhythmia with or without “bronze diabetes,” is mandatory. Am. J. Hematol., 2008. © 2007 Wiley‐Liss, Inc.
Glutathione S-Transferase-P1 Expression Correlates with Increased Antioxidant Capacity in Transitional Cell Carcinoma of the Urinary Bladder
Authors: Ana Savic-Radojevic, Jasmina Mimic-Oka, Marija Pljesa-Ercegovac, Marija Opacic, Dejan Dragicevic, Tamara Kravic, Milan Djokic, Sava Micic, Tatjana Simic
Journal: European Urology (2007)
Cancer units are implementing changes from generic to specialist practice
Authors: R A Haward, Z. Amir
Journal: BMJ (1997)

Editor–The Policy Framework for Commissioning Cancer Services produced by the chief medical officers of England and Wales, with equivalent documents in Scotland and Northern Ireland, recommends appreciable changes in the provision of cancer services.1 The report introduces a network of services linking primary care, cancer units, and cancer centres. The concept of cancer units is new and requires changes in clinical organisation.2 Implementation of this policy demands an increase in clinical or medical oncology sessions at unit level to a minimum of five weekly sessions. A …
Rapid Diagnosis of Sedative Intoxication by Gas Chromatography
Authors: H. ALLAN BLOOMER
Journal: Annals of Internal Medicine (1970)

The increasing use of diuresis and dialysis for treating patients with drug coma has created a need for rapid and detailed toxicologic information about the unconscious patient. A gas chromatography method was used to screen plasma in 41 patients with suspected drug coma. In 37 instances either a barbiturate, meprobamate, glutethimide, or a combination of these sedatives was found in sufficient concentrations to explain the coma. In over one half of these cases the history available at the time of admission was unreliable for determining the responsible drug. Gas-liquid chromatography is uniquely suited for the rapid diagnosis of drug intoxication since it permits simultaneous identification and measurement of a variety of sedative agents.
Aspirin‐sensitive urticaria: provocation with a leukotriene receptor antagonist
Authors: None Ohnishi‐Inoue, None Mitsuya, None Horio
Journal: British Journal of Dermatology (1998)

The diagnosis of two patients with aspirin-induced urticaria (AIU) was confirmed by oral provocation with aspirin, other non-steroidal anti-inflammatory drugs, and food additives. Low doses of a novel leukotriene (LT) receptor antagonist, ONO-1078 (ONO, Japan) induced urticaria in these patients, while the same doses of ONO-1078 did not provoke any eruptions in 10 normal healthy volunteers or five patients with aspirin-unrelated chronic urticaria. This is the first report that a selective LTD4/LTE4 receptor antagonist that is effective as an antiasthmatic agent evoked urticaria in patients with AIU. Our observation suggests that the pathogenesis of AIU depends on the stimulation of LT receptors. The accumulation of results of anti-LT therapy may provide clues to resolve the pathogenetic mechanisms of this disorder.
Effectiveness of Adenoidectomy and Tympanostomy Tubes in the Treatment of Chronic Otitis Media with Effusion
Authors: G A Gates, C A Avery, T J Prihoda, J C Cooper
Journal: New England Journal of Medicine (1987)

To study the effectiveness of adenoidectomy and of the placement of tympanostomy tubes in the treatment of chronic otitis media with effusion, we randomly assigned 578 children, aged four through eight years, to receive bilateral myringotomy and no additional treatment (Group 1), placement of tympanostomy tubes (Group 2), adenoidectomy (Group 3), or adenoidectomy and placement of tympanostomy tubes (Group 4). The 491 children who underwent one of these treatments were examined at six-week intervals for up to two years. The mean time spent with effusion of any type in either ear over the two-year follow-up in the four groups was 51, 36, 31, and 27 weeks, respectively (P less than 0.0001), comparing Group 1 with each of the other groups. Hearing was equivalent in Groups 2, 3, and 4, and was significantly better than in Group 1. The most frequent sequela, purulent otorrhea, occurred one or more times in 22, 29, 11, and 24 percent of the subjects in Groups 1, 2, 3, and 4, respectively (P less than 0.001). Adenoidectomy plus bilateral myringotomy lowered the overall post-treatment morbidity (as measured by hearing acuity in the most severely affected ear [P = 0.0174] and the number of surgical retreatments required [P = 0.009]) more than did tympanostomy tubes alone and to the same degree as did adenoidectomy and tympanostomy tubes. We conclude that adenoidectomy should be considered when surgical therapy is indicated in children four to eight years old who are severely affected by chronic otitis media with effusion.
Preclinical vascular damage in white postmenopausal women: the relevance of osteoprotegerin
Authors: Donatella Siepi, Simona Marchesi, Gaetano Vaudo, Graziana Lupattelli, Francesco Bagaglia, Matteo Pirro, Matteo Brozzetti, Anna Rita Roscini, Elmo Mannarino
Journal: Metabolism (2008)
Alopecia as a Side Effect of Treatment of Epilepsy with Trimethadione
Authors: Jean Holowach, Howard V. Sanden
Journal: New England Journal of Medicine (1960)

RECENTLY, we observed 2 patients in whom alopecia developed during trimethadione‡ therapy. In each case withdrawal of the drug was followed by prompt regrowth of scalp hair. Such a side reaction to this drug has not previously been reported in the medical literature. During the fourteen years in which it has been used in clinical medicine, the manufacturer had received only 2 reports (both in 1959) of hair loss occurring in patients whose therapeutic regimen included trimethadione.§ Further details and follow-up data in these 2 cases were not submitted to the manufacturer.Case ReportsCase 1. M.M., an 8-year-old girl, . . .
Selective estrogen receptor modulation attenuates proteinuria-induced renal tubular damage by modulating mitochondrial oxidative status
Authors: Yuko Nishi, Minoru Satoh, Hajime Nagasu, Hiroyuki Kadoya, Chieko Ihoriya, Kengo Kidokoro, Tamaki Sasaki, Naoki Kashihara
Journal: Kidney International (2013)
Nucleation time and lipid and protein composition of gallblader bile after administration of urso or a cheno-urso combination
Authors: S.Ginanni Corradini, M. Angelico, L. Boiocchi, C. Giambalyo, L. Giacomelli, L. Basso, A. Cantafora, L. Capocaccia
Journal: Journal of Hepatology (1991)
THE BEHAVIOR OF CHILDREN RECEIVING BENZEDRINE
Authors: Charles Bradley
Journal: American Journal of Psychiatry (1937)

The psychological reactions of 30 behavior problem children who received benzedrine sulfate for one week were observed. There was a spectacular improvement in school performance in half of the children. A large proportion of the patients became emotionally subdued without, however, losing interest in their surroundings. A variety of other definite behavior changes were also noted. Dosage, unfavorable responses, and duration of effect of the drug are discussed, and it is suggested that its use in the treatment of children with behavior disorders be supervised by physicians trained in child psychiatry.
Electrocardiographic Changes during Hemodialysis with the Artificial Kidney
Authors: ALBERT L. RUBIN, GLENN D. LUBASH, BURTON D. COHEN, DAVID BRAILOVSKY, WARREN S. BRAVEMAN, E. HUGH LUCKEY
Journal: Circulation (1958)

Rapid alteration of plasma, electrolyte concentrations during dialysis with the artificial kidney may be associated with changes in the electrocardiogram and in cardiac function. In this study, the electrocardiographic changes encountered during 33 hemodialyses are described and correlated with abnormal electrolyte patterns and their correction.
A Comparison of the Frequency of Hepatitis-B Antigen and Antibody in Hospital and Nonhospital Personnel
Authors: Thomas L. Lewis, Harvey J. Alter, Thomas C. Chalmers, Paul V. Holland, Robert H. Purcell, David W. Alling, Donald Young, Lawrence D. Frenkel, Stephanie L. Lee, Margaret E. Lamson
Journal: New England Journal of Medicine (1973)

Abstract The frequency of hepatitis B antigen and antibody among health-care personnel was compared with that among matched controls with no exposure to patients or blood products. The frequency of the antigen in personnel and controls did not differ significantly. However, the causes may have been different, the antigen correlating with past transfusion in the controls but not in personnel. A history of past hepatitis did not correlate with antigenemia in either population, impugning the validity of hepatitis history as a cause for donor exclusion. Antibody was twice as frequent in health personnel, indicating increased exposure to the antigen; antibody correlated with past hepatitis in personnel, but not in controls, suggesting that overt hepatitis B infection is more common among health personnel. The frequency of hepatitis B antigen among health workers is not currently alarming, but the risk that each antigen-positive health worker represents to his patients remains unknown. (N Engl J Med 289:647–651...
Case of Multiple Embolism with Repeated Embolectomy
Authors: E. N. Callum
Journal: BMJ (1948)

TWO CASES OF TETANUS NEONATORUM MEDICALTIJHRNAL 981 brands of baby powder were obtained to act as controls.All the samples of powder of the brand used in Case 2 showed the presence of numerous anaerobic organisms, though Cl. tetani was not isolated, while the control powders gave no such growth.The makers of the suspect powder were approached and submitted the various raw materials used in its manufacture.These were: aluminium silicate (kaolin), magnesium Silicate, boric acid, and perfume.The last three ingredients proved to be blameless, but from the kaolin an anaerobic spore-bearing bacillus was isolated, which, however, proved to be avirulent on animal inoculation.The use of this kaolin in the manufacture of the powder was discontinued by the manufacturers.Summary Two cases of tetanus neonatorum are described.Investigation of the origin of the infection suggests that the dusting powder used in one case may have been the cause.The origin of infection in the other case remains uncertain.Our thanks are due to Prof. N. B. Capon for permission to publish the case histories; to Prof. W. M
Contraceptive information and promiscuity.
Authors: M E Denyer, R K Sanders
Journal: BMJ (1977)

and cutaneous anergy to DNCB'2-15 in a substantial proportion of patients with in- flammatory bowel disease, Crohn's disease, and ulcerative colitis alike.We have also noted that in ulcerative colitis the anergy appears to reverse after colectomy, whereas in Crohn's disease it persists despite surgical resection.'4 15 These facts should help provide a clear and definitive answer to your rhetorical "fact or fiction" question.The establishment of anergy as a feature of Crohn's disease may not be a "breakthrough," but it certainly is a fact.