tbuckley/cabot-search huggingface dataset:
A Quantitative Synthesis of Mercury in Commercial Seafood and Implications for Exposure in the United States
Authors: Roxanne Karimi, Timothy P. Fitzgerald, Nicholas S. Fisher
Journal: Environmental Health Perspectives (2012)

Background: Mercury (Hg) is a toxic metal that presents public health risks through fish consumption. A major source of uncertainty in evaluating harmful exposure is inadequate knowledge of Hg concentrations in commercially important seafood.Objectives: We examined patterns, variability, and knowledge gaps of Hg in common commercial seafood items in the United States and compared seafood Hg concentrations from our database to those used for exposure estimates and consumption advice.Methods: We developed a database of Hg concentrations in fish and shellfish common to the U.S. market by aggregating available data from government monitoring programs and the scientific literature. We calculated a grand mean for individual seafood items, based on reported means from individual studies, weighted by sample size. We also compared database results to those of federal programs and human health criteria [U.S. Food and Drug Administration Hg Monitoring Program (FDA-MP), U.S. Environmental Protection Agency (EPA)].Results: Mean Hg concentrations for each seafood item were highly variable among studies, spanning 0.3–2.4 orders of magnitude. Farmed fish generally had lower grand mean Hg concentrations than their wild counterparts, with wild seafood having 2- to12-fold higher concentrations, depending on the seafood item. However, farmed fish are relatively understudied, as are specific seafood items and seafood imports from Asia and South America. Finally, we found large discrepancies between mean Hg concentrations estimated from our database and FDA-MP estimates for most seafood items examined.Conclusions: The high variability in Hg in common seafood items has considerable ramifications for public health and the formulation of consumption guidelines. Exposure and risk analyses derived from smaller data sets do not reflect our collective, available information on seafood Hg concentrations.
A novel 18-amino acid deletion in apolipoprotein E associated with lipoprotein glomerulopathy
Authors: Minoru Ando, Jun Sasaki, Han Hua, Akira Matsunaga, Keiko Uchida, Kensuke Jou, Shinichi Oikawa, Takao Saito, Hiroshi Nihei
Journal: Kidney International (1999)
Pathergy in non-Hodgkin lymphoma
Authors: I. A Burney, T. Moatter, T. Siddiqui, N. Yaqoob
Journal: Journal of the Royal Society of Medicine (2003)

Pathergy is the development of a papulopustular lesion around a puncture site on the skin, 24-48 hours after the injection of a sterile substance1. The pathergy test is used in some parts of the world as a diagnostic criterion for Behcet's disease2.
Database study of antibiotic resistant tuberculosis in the United Kingdom, 1994-6
Authors: C. Irish, J. Herbert, D. Bennett, C. Gilham, F. Drobniewski, R. Williams, E G. Smith, J. G Magee, B. Watt, M. Chadwick, J. M Watson
Journal: BMJ (1999)

The global increase in tuberculosis which has occurred in the 1980s and 1990s, and the associated re-emergence of resistance to antituberculous drugs, has focused attention on recent trends in resistance in Europe and the United States.1–3 In the United Kingdom overall drug resistance levels have been low.4 A surveillance system, the UK Mycobacterial Resistance Network (MYCOBNET), was established in 1994 by the Public Health Laboratory Service to record drug resistance in laboratory isolates of tuberculosis. We used data from this network to examine resistance among people with newly diagnosed tuberculosis.

We analysed the data on initial isolates of Mycobacterium tuberculosis complex referred to United Kingdom reference laboratories5 during 1994 to 1996. Initial isolates were defined as the first positive culture from a person from whom no positive culture had been recorded during the past 12 months. Since M bovis isolates are intrinsically resistant to pyrazinamide …
Oestrogens for menopausal flushing.
Authors: E R Broadhurst
Journal: BMJ (1976)

suggested by Mr Pearson and Miss Weaver, record many fewer movements per unit time than when they record for shorter periods.Presumably this is an effect of fatigue and reduced alertness.Recording during meals, conversation, reading, listening to music, etc, is not reliable.We instruct the women to assess and record each fetal movement for periods of 30-60 min three times a day.If the number of movements is less than three per hour the recording is continued for 6-12 hours in the day.From the sum of the movements recorded the rate per 12 hours-daily fetal movement recording (DFMR)-is calculated.Employing this method for a total of 1 5-3 hours a day the computed DFMR in 114 women with a normal outcome varied between 4 and 1440 per 12 hours.The majority of DFMRs were between 200 and 600 per 12 hours.In addition, the number of fetal movements recorded by an electromagnetic device' varied between 25 and 235 per hour.The patients recorded 87'. of
Management of Bacterial Shock
Authors: John N. Minuth
Journal: JAMA (1976)

To the Editor.—  Gentamicin sulfate administered to patients with renal failure at intervals between doses as recommended by Shubin and Weil (235:421, 1976) leads to serum levels below 1μg/ml (Ann Intern Med74:192, 1971), which could persist for long periods if renal function improves before the next dose. We recently treated such a patient with traumatic bowel perforation and a creatinine level of 7.5 mg/100 ml with a maintenance dose of 30 mg every eight hours the first day. This was increased to 50 mg by the fourth day because the creatinine level had decreased to 5.1 mg/100 ml. Using the schedule shown by Shubin and Weil, the patient would not have received gentamicin for four full days after his initial loading dose. I believe Chan's nomogram for giving a reduced dose of gentamicin every eight hours (Ann Intern Med76:773, 1972) allows for better control of serious infection by
The case of the neglected alphasyllabary: Orthographic processing in Devanagari
Authors: Chaitra Rao, Shweta Soni, Nandini Chatterjee Singh
Journal: Behavioral and Brain Sciences (2012)

Abstract We applaud Ram Frost for highlighting the need for multicultural perspectives while developing universal models of visual word recognition. We second Frost's proposal that factors like lexical morphology should be incorporated besides purely orthographic features in modeling word recognition. In support, we provide fresh evidence from Hindi (written in Devanagari), an example of hitherto under-represented alphasyllabic orthographies, in which flexible encoding of akṣara (character) position is constrained by the morphological structure of words.
Immunoglobulin-bearing and complement-receptor lymphocytes constitute the same population in human peripheral blood.
Authors: A G Ehlenberger, M McWilliams, J M Phillips-Quagliata, M E Lamm, V Nussenzweig
Journal: Journal of Clinical Investigation (1976)

Complement-receptor lymphocytes have generally been considered to be a subpopulation of bone-marrow derived (B) lymphocytes. However, the present studies show that essentially all cells with integral surface immunoglobulin from normal human peripheral blood bear receptors for the third component of complement. Moreover, after removal of phagocytes, all cells with complement receptors bear surface Ig. Thus, circulating B cells and complement-receptor lymphocytes are the same population.
Further Advantages of a Unique Author Identification Number
Authors: Etienne Joly
Journal: PLoS Medicine (2006)

I read the paper by Chi et al. with interest.The authors found a greater hypoxia response gene expression in carcinomas than stromal cells grown in vitro, but were not sure of the underlying explanation (see Discussion in [1]).The underlying explanation may be the difference in mitotic activity and hence metabolic activity between these two cell types, such that hypoxia may be present within cancer cells, although the surrounding culture media may have similar oxygen levels as the stromal cultures.The differences in mitotic activity could also explain greater hypoxia-related gene expression in clear-cell carcinoma compared with chromophobe carcinoma, normal tissue, or oncocytoma, as clear-cell carcinomas are more active mitotically.Did the authors compare the hypoxia gene expression with mitotic activity in various tumors?
Multifocal Epithelioid Hemangioendothelioma of the Lower Limbs Detected by 18F-FDG PET/MRI
Authors: Giorgio Treglia, Luca Ceriani, Gaetano Paone, Tiziana Rusca, Massimo Bongiovanni, Luca Giovanella
Journal: Clinical Nuclear Medicine (2014)

A 38-year-old man underwent surgical excision of a 1.5-cm subcutaneous nodule of the left leg. Histologic evaluation demonstrated the presence of an epithelioid hemangioendothelioma (EHE). The patient underwent 18F-FDG PET/MRI for staging. This examination demonstrated the presence of several soft tissue and bone lesions in the left lower limb without evidence of distant metastatic disease. The final diagnosis was multifocal EHE of the left lower limb. In this case, 18F-FDG PET/MRI has been very useful in the correct staging of this rare presentation of EHE of the lower limbs.
Analysis of BCL-6, CD95, PIM1, RHO/TTF and PAX5 mutations in splenic and nodal marginal zone B-cell lymphomas suggests a particular B-cell origin
Authors: A Traverse-Glehen, A Verney, L Baseggio, P Felman, E Callet-Bauchu, C Thieblemont, M Ffrench, J-P Magaud, B Coiffier, F Berger, G Salles
Journal: Leukemia (2007)
A comparison between fine-needle biopsy and fiberoptic bronchoscopy in patients with lung lesions
Authors: S. Borgeskov, D. Francis
Journal: Thorax (1974)

<b>Borgeskov, S. and Francis, D. (1974).</b><i>Thorax</i>, <b>29</b>, 352-354. <b>A comparison between fine-needle biopsy and fiberoptic bronchoscopy in patients with lung lesions.</b> We present a series of 40 patients with lung lesions in whom a specific diagnosis was not obtained by conventional methods of examination and in whom tumour was not visualized directly by bronchoscopy with a flexible bronchoscope. Bronchial brushing and blind biopsy-taking were performed and the results were compared with those of fine-needle aspiration biopsy. The percentage of diagnoses for the two methods was 30 and 62 respectively. In 40% of cases the diagnosis was obtained solely by fine-needle aspiration biopsy and in 10% alone with the aid of the flexible bronchoscope.
THE SWINE LUNGWORM AS A RESERVOIR AND INTERMEDIATE HOST FOR SWINE INFLUENZA VIRUS
Authors: Richard E. Shope
Journal: The Journal of Experimental Medicine (1941)

1. The swine lungworm can serve as intermediate host in transmitting swine influenza virus to swine. The virus is present in a masked non-infective form in the lungworm, however, and, to induce infection, must be rendered active by the application of a provocative stimulus to the swine it infests. Multiple intramuscular injections of H. influenzae suis furnish a means of provoking infection. Swine influenza infections can be provoked in properly prepared swine during the autumn, winter, and spring, but not during the summer. The phenomenon, while not regularly reproducible, occurs in well over half the experiments conducted outside the refractory period of summer. No explanation for the failures is apparent. 2. The virus can persist in its lungworm intermediate host for at least 2 years. 3. Swine infected with swine influenza virus by way of the lungworm intermediate host exhibit a more pronounced pneumonia of the posterior lobes of the lung than do animals infected intranasally with virus. The situation of the worms providing the virus will account for this. 4. Occasional swine infested with lungworms carrying influenza virus fail to become clinically ill after provocation but instead become immune. In these it is believed that lungworms containing the virus are localized outside the respiratory tract at the time of provocation. 5. It is believed that the experiments described furnish an explanation for the findings recorded in the preceding paper, in which swine influenza virus infections were induced in apparently normal swine by multiple injections of H. influenzae suis. 6. In a single experiment swine lungworms failed to transmit hog cholera virus.
Welcome award: belated justice
Authors: K W Way
Journal: BMJ (1980)

had low toxicity and gave an overall response rate of 73%0.In the multicentre study in 153 patients there were no drug-related deaths.We conclude that intracavitary bleomycin is well tolerated and is effective as palliative treatment for malignant effusions, preventing the need for frequent aspiration of accumulated fluid.Because of its lack of haematological toxicity it may be used safely in the already leucopenic patient.
Occurrence of different ensuing triggering infections preceding reactive arthritis: a follow up study
Authors: Y. T Konttinen, D. C Nordstrom, V. Bergroth, M. Leirisalo-Repo, S. Santavirta
Journal: BMJ (1988)

5 observations d'arthrite reactive typique. Tous les sujets sont positifs pour HLA-B27, aucun ne presente d'antecedents familiaux de spondylite ankylosante ou d'arthrite rhumatoide. L'arthrite reactive se manifeste 1 a 3 semaines apres l'infection declenchante. Rechutes au bout de 1, 5 a 11 ans. Dans 2 cas les recidives atteignent plusieurs articulations et des signes radiologiques d'erosion sont presents; il s'agirait de syndrome de Reiter chronique
PET/CT Appearance of Non-Hodgkin Lymphoma of the Vermiform Appendix
Authors: Frederico F. Souza, David A. Israel
Journal: Clinical Nuclear Medicine (2008)

We present a case of a 53-year-old man with large B-cell non-Hodgkin lymphoma that infiltrated the vermiform appendix. The patient underwent F-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT scan) for staging, which demonstrated intense abnormal tracer uptake in the appendix. After 2 cycles of chemotherapy (R-CHOP), a follow-up PET/CT scan demonstrated complete resolution of the abnormal tracer uptake within the appendix. This case highlights the contribution of F-18 FDG PET/CT in the diagnosis and post-therapy evaluation of this involvement.
Recent advances in laser treatment of port-wine stains
Authors: S.W. Lanigan, S.M. Taibjee
Journal: British Journal of Dermatology (2004)

Journal Article Recent advances in laser treatment of port‐wine stains Get access S.W. Lanigan, S.W. Lanigan Lasercare Clinics, Birmingham Skin Centre, City Hospital, Dudley Road, Birmingham B18 7QH, U.K Search for other works by this author on: Oxford Academic Google Scholar S.M. Taibjee S.M. Taibjee Lasercare Clinics, Birmingham Skin Centre, City Hospital, Dudley Road, Birmingham B18 7QH, U.K S.M.Taibjee. E‐mail: saleemtaibjee@blueyonder.co.uk Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 151, Issue 3, 1 September 2004, Pages 527–533, https://doi.org/10.1111/j.1365-2133.2004.06163.x Published: 01 September 2004 Article history Accepted: 29 March 2004 Published: 01 September 2004
BILIRUBIN AND UROBILINS IN GERMFREE, EX-GERMFREE, AND CONVENTIONAL RATS
Authors: Bengt E. Gustafsson, Lisa Swenander Lanke
Journal: The Journal of Experimental Medicine (1960)

No urobilinogens are present in the feces or urine of germfree rats. After contamination of germfree animals with feces from conventional animals the exgermfree rats produced urobilins to the same extent as conventional animals on the same diet. The negative urobilin test turned positive in germfree animals infected with a single Clostridium-like microorganism isolated from the intestinal contents of rats with urobilins in the feces. The output increased in these monoinfected animals after superinfection with a strain of E. coli but never reached the values of conventional animals.
beta-adrenergic blockade in essential hypertension: reduced renin release despite renal vasoconstriction.
Authors: J M Sullivan, D F Adams, N K Hollenberg
Journal: Circulation Research (1976)

The acute effects of small doses of intravenous propranolol on renin release and on circulatory dynamics were studied at the time of renal arteriography in 12 persons with essential hypertension. All of the subjects had a normal peripheral renin response to chronic sodium depletion and all had normal renal function. Seven subjects received a 10-mEq sodium diet. At the time of arteriography, arterial blood pressure, pulse rate, cardiac output, renal blood flow, and arterial and renal venous renin activity were measured before and 6-20 minutes after the intravenous administration of propranolol (9-18 mjg/kg). Average renin secretion rate in the salt-depleted subjects fell from 367 +/- 80 (SEM) U/ml per 100 g/min to 122 +/- 51 U/ml per 100 g (P=0.03) and renal plasma flow fell from 189 to 155 ml/min per 100 g (P = 0.018). We also found that in the salt-loaded subjects, renal plasma flow fell from 213 to 184 ml/min per 100 g (P = 0.025), whereas renin secretion did not change significantly in either group. We conclude that propranolol rapidly blocks renin release despite circulatory changes which ordinarily constitute a stimulus for renin secretion, i.e., renal vasoconstriction and reduced renal blood flow.
Combined Care of the Rheumatic Patient
Authors: John F. Beary
Journal: JAMA (1985)

This book is a delight to read. Its theme is the multidisciplinary care of patients with rheumatic disease. The book is organized around three sections. Section I (chapters 1 through 3) reviews diagnosis and therapy of rheumatic diseases from a British perspective, which leads one to useful and interesting insights into the approach we apply to similar problems in the United States. Section II (chapters 4 through 6) reviews the contributions of nursing professionals, occupational therapists, and physiotherapists to patient care. The third section (chapters 7 through 12) lays out a comprehensive "combined care" approach to the many needs of patients suffering from arthritis. A team member called a "metrologist" is described. This person is a nurse practitioner who provides active patient care and also makes clinical assessments and measurements for clinical research protocols. An immediate yield of this innovative approach has been a marked decrease in drug trial drop-out
Distribution and Physiological Roles of ATP-Sensitive K <sup>+</sup> Channels in the Vertebrobasilar System of the Rabbit
Authors: Tetsuhiko Nagao, Setsuro Ibayashi, Seizo Sadoshima, Koji Fujii, Kenichiro Fujii, Yusuke Ohya, Masatoshi Fujishima
Journal: Circulation Research (1996)

The effect of an opener (levcromakalim) and a blocker (glibenclamide) of ATP-sensitive K+ (KATP) channels was investigated in the vertebrobasilar system of the rabbit. Arterial tension and membrane potential were measured by the isometric tension recording method and the microelectrode technique, respectively. Glibenclamide (10(-6) mol/L) depolarized the membrane and potentiated the contraction to histamine in vertebral arteries. The sensitivity to the relaxant effects of levcromakalim was in the following descending order: vertebral > proximal basilar > distal basilar > superior cerebellar arteries. Vertebral arteries were approximately 50 times more sensitive to levcromakalim than were superior cerebellar arteries. The relaxation to levcromakalim was abolished by glibenclamide (10(-6) mol/L). Glibenclamide attenuated vasorelaxation to adenosine in proximal arteries (vertebral and proximal basilar) but not in superior cerebellar arteries. Levcromakalim (7 x 10(-8) mol/L) and adenosine (10(-5) mol/L) induced glibenclamide-sensitive membrane hyperpolarization in vertebral arteries but not in distal basilar arteries. These results suggest that KATP channels contribute to the determination of resting membrane potential and resting tone in vertebral arteries. Furthermore, there is a marked heterogeneity in the sensitivity to an opener of KATP channels, and the heterogeneity has a functional link to the mechanism underlying vasorelaxation to adenosine in the vertebrobasilar system of the rabbit.
Feasibility, sensitivity, and reliability of laser-induced fluorescence imaging of green fluorescent protein-expressing tumors in vivo
Authors: Severine Wack, Amor Hajri, Francine Heisel, Malgorzata Sowinska, Cedric Berger, Maurice Whelan, Jacques Marescaux, Marc Aprahamian
Journal: Molecular Therapy (2003)

Whole-body imaging of green fluorescent protein (GFP) can be used to test the efficiency of gene carriers for in vivo transduction. The aim of the current study was to determine the sensitivity and the accuracy of a GFP imaging procedure by in vivo investigation of GFP-expressing tumor cells. An improved method of whole-body GFP imaging made use of a laser excitation source and band-pass filters matched specifically to GFP and constitutive tissue fluorescence emission bands. Processing of the primary GFP fluorescence images acquired by the CCD camera subtracted background tissue autofluorescence. Our approach achieved 100% sensitivity and specificity for in vivo detection of 10%-transfected BxPc3 pancreatic tumor after subcutaneous grafting or orthotopical implantation in the pancreas of nude mice. It also detected less transfected tumors (i.e., 1 to 5%) but with a loss in sensitivity (50% of cases). The system was employed over a 5-week period to monitor the persistence of GFP expression in 10%-transfected BxPc3 tumors orthotopically implanted in the pancreas of two nude mice, allowing the direct visualization of tumor progression and spread. In facilitating the temporal-spatial follow-up of GFP expression in vivo, the optimized laser-induced fluorescence imaging device can support preclinical investigations of vectors for therapeutic gene transduction through regular, harmless, real-time monitoring of theirin vivo transductional efficacy and persistence.
THE NATURE OF THE RESPONSE OF THE MUSCLES TO FARADIC STIMULATION
Authors: F. A. CAJORI
Journal: JAMA (1928)

Electricity has found a rather wide use in medicine, and various forms of it have been employed therapeutically in the treatment of many diseases. There is as yet insufficient knowledge of the physiologic response of the body to the several forms of the electric current to make possible an explanation of the benefit that is alleged to occur in many cases from such treatment.  A number of workers have reported that a general stimulation of metabolism, as evidenced by an increased excretion of metabolic end-products, follows several kinds of electrical stimulation. The work of Steel1may be mentioned in this connection. He determined the urinary output of water, total solids, nitrogen, urea, creatinine and sulphur for a three day period, during which his subject received certain electrical treatments, and contrasted the results with the composition of the urine of the same subject for like periods before and after. In
Prostate Cancer Screening—Time to Abandon One-Size-Fits-All Approach?
Authors: Jeri Kim, John W. Davis
Journal: JAMA (2011)

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