Goodpasture's Syndrome
Authors: R. K. MADDOCK
Journal: Annals of Internal Medicine (1967)

Case Studies1 December 1967Goodpasture's SyndromeCessation of Pulmonary Hemorrhage After Bilateral NephrectomyR. K. MADDOCK JR., M.D., L. E. STEVENS, M.D., K. REEMTSMA, M.D., H. A. BLOOMER, M.D., F.A.C.P.R. K. MADDOCK JR., M.D.Search for more papers by this author, L. E. STEVENS, M.D.Search for more papers by this author, K. REEMTSMA, M.D.Search for more papers by this author, H. A. BLOOMER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-6-1258 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn its characteristic form Goodpasture's syndrome is a disease of young white men, who develop fulminating glomerulonephritis, hemorrhagic pneumonitis, and severe anemia. The affliction is usually fatal within a few months, the victim dying in uremia or of massive pulmonary hemorrhage. The consistent clinical course and the histologic findings establish Goodpasture's syndrome as a specific disease, distinct from other disorders involving kidney and lung such as periarteritis nodosa and idiopathic pulmonary hemosiderosis (1). However, the etiology is unknown, the connection between the renal and pulmonary manifestations has not been defined, and treatment is usually unsuccessful.Our recent experiences with two...References1. BENOITRULONTHEILDOOLANWATTEN FLDBGBPDRH: Goodpasture's syndrome: a clinicopathologic entity. Amer. J. Med. 37: 424, 1964. CrossrefMedlineGoogle Scholar2. DE GOWINODAEVANS RLYRH: Nephritis and lung hemorrhage: Goodpasture's syndrome. Arch. Intern. Med. (Chicago) 111: 16, 1963. CrossrefMedlineGoogle Scholar3. TORINGREGORATOS DEG: Goodpasture's syndrome. Report of a case with renal biopsy and autopsy findings. Milit. Med. 128: 628, 1963. CrossrefMedlineGoogle Scholar4. BLOOMWAYNEWRONG VRDJOM: Lung purpura and nephritis (Goodpasture's syndrome) complicated by the nephrotic syndrome. Ann. Intern. Med. 63: 752, 1965. LinkGoogle Scholar5. STANTONTANGE MCJD: Goodpasture's syndrome: pulmonary haemorrhage associated with glomerulonephritis. Aust. Ann. Med. 7: 132, 1958. CrossrefMedlineGoogle Scholar6. DUNCANDRUMMONDMICHAELVERNIER DAKNAFRL: Pulmonary hemorrhage and glomerulonephritis. Report of six cases and study of the renal lesion by the fluorescent antibody technique and electron microscopy. Ann. Intern. Med. 62: 920, 1965. LinkGoogle Scholar7. RUSBYWILSON NLC: Lung purpura with nephritis. Ann. Rev. Med. 16: 301, 1965. CrossrefMedlineGoogle Scholar8. SHIRESCADE DLR: Personal communication. Google Scholar9. CLEVELANDLEEPROUTHUME RJHMGRDM: Preservation of the cadaver kidney for renal homotransplantation in man. Surg. Gynec. Obstet. 119: 991, 1964. MedlineGoogle Scholar10. FREEMANVERTELEASTERLING RMRMRE: Goodpasture's syndrome. Prolonged survival with chronic hemodialysis. Arch. Intern. Med. (Chicago) 117: 643, 1966. CrossrefMedlineGoogle Scholar11. BAXTERGOODMAN JHHC: Nephrotoxic serum nephritis in rats. I. Distribution and specificity of the antigen responsible for the production of nephrotoxic antibodies. J. Exp. Med. 104: 467, 1956. CrossrefMedlineGoogle Scholar12. SCHEERGROSSMAN RLMA: Immune aspects of the glomerulonephritis associated with pulmonary hemorrhage. Ann. Intern. Med. 60: 1009, 1964. LinkGoogle Scholar13. STURGILLWESTERVELT BCFB: Immunofluorescence studies in a case of Goodpasture's syndrome. JAMA 194: 914, 1965. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Salt Lake City, UtahFrom the Departments of Internal Medicine and Surgery, University of Utah College of Medicine and Veterans Administration Hospital, Salt Lake City, Utah.This study was supported in part by grants AM-2 and FR-64, National Institutes of Health, Bethesda, Md.Requests for reprints should be addressed to H. A. Bloomer, M.D., Veterans Administration Hospital, 500 Foothill Blvd., Salt Lake City, Utah 84113. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByPathogenesis: immunogenetic factorsFamilial occurrence of systemic vasculitis and rapidly progressive glomerulonephritisPULMONARY MANIFESTATIONS OF GOODPASTURE'S SYNDROMEBilateral nephrectomy stopped disease progression in plasma-resistant hemolytic uremic syndrome with neurological signs and comaLe syndrome de Goodpasture: rôle d'un facteur épidémiologique ? 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SANDS, F.R.A.C.P.IronGoodpasture's syndrome in a patient with the nail-patella syndromeGoodpasture's Syndrome (Pulmonary Hemosiderosis with Nephritis)Allergic Renal DiseasesExperience with One-Stage Bilateral NephrectomySerial complement studies in a patient with Goodpasture's syndrome treated with bilateral nephrectomy and renal transplantationReversal of hypercoagulable state by bilateral nephrectomyRenal homotransplantationRenal homotransplantationAllergic lung Diseases Not Mediated by IgEProliferative glomerulonephritis and pulmonary hemorrhageAnti-glomerular basement membrane antibody-induced glomerulonephritisPulmonary involvements in the initial phase of rat Masugi nephritisDiseases Due to Immunologic Reactions in the LungsGoodpasture's SyndromeRemission in Goodpasture's syndrome: report of two patients treated by immunosuppression and review of the literatureGoodpasture's Syndrome: Recovery from Severe Pulmonary Hemorrhage After Bilateral NephrectomyANDREW NOWAKOWSKI, ROBERT B. GROVE, LEROY H. KING JR., TATIANA T. ANTONOVYCH, M.D., ROBERT W. FORTNER, MARTIAL R. KNIESER, CHARLES B. CARTER, JAMES H. KNEPSHIELDGoodpasture's SyndromeGoodpasture's syndromeLUNG HAEMORRHAGE AND NEPHRITIS (GOODPASTURE'S SYNDROME)Renal Role in Goodpasture's SyndromeCase 15-1969ULTRA‐FULMINANT GOODPASTURE'S SYNDROMEGLOMERULONEPHRITIS WITH INITIAL LUNG PURPURA (GOODPASTURE'S SYNDROME)Retention of Radioiron in the Lungs of a Woman with Idiopathic Pulmonary HemosiderosisRICHARD L. DEGOWIN, M.D., LEIF B. SORENSEN, M.D., DONALD B. CHARLESTON, M.S., ALEXANDER GOTTSCHALK, M.D., JAMES H. GREENWALD, M.D. 1 December 1967Volume 67, Issue 6Page: 1258-1264KeywordsEtiologyGlomerulonephritisHemorrhageHospital medicineLungsPneumonitisPulmonary diseasesRenal diseasesSaltsSurgery Issue Published: 1 December 1967 PDF DownloadLoading ...