Hepatitis A Virus-associated Cholecystitis
Authors: Samir Mourani
Journal: Annals of Internal Medicine (1994)

Brief Reports1 March 1994Hepatitis A Virus-associated CholecystitisSamir Mourani, MD, Stuart M. Dobbs, MD, Robert M. Genta, MD, Atul K. Tandon, PhD, and Boris Yoffe, MDSamir Mourani, MDFrom the Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas; BioGenex Laboratories, San Ramon, California., Stuart M. Dobbs, MDFrom the Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas; BioGenex Laboratories, San Ramon, California., Robert M. Genta, MDFrom the Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas; BioGenex Laboratories, San Ramon, California., Atul K. Tandon, PhDFrom the Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas; BioGenex Laboratories, San Ramon, California., and Boris Yoffe, MDFrom the Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas; BioGenex Laboratories, San Ramon, California.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-5-199403010-00008 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Cholestatic hepatitis [1] and cholecystitis [2, 3] are poorly recognized manifestations of acute hepatitis A virus (HAV) infection. Although previous studies showed that HAV-associated RNA and antigen are present predominantly in hepatocytes and, to a lesser extent, in Kupffer cells, the pathogenesis of these abnormalities remains unknown [4]. To understand better the mechanisms of HAV-associated cholestasis and cholecystitis, we did an immunohistochemical analysis of liver and gallbladder specimens from an elderly patient with cholestatic hepatitis A and acalculous cholecystitis. A microscopic examination revealed portal inflammation and pericholangitis as well as cholestasis in the liver and lymphocytic cholecystitis. In contrast to ...References1. Gordon SC, Reddy KR, Schiff L, Schiff ER. Prolonged intrahepatic cholestasis secondary to acute hepatitis A. Ann Intern Med. 1984; 101:635-7. Google Scholar2. Black MM, Mann NP. Gangrenous cholecystitis due to hepatitis A infection. J Trop Med Hyg. 1992; 95:73-4. Google Scholar3. Hermier M, Descos B, Collet JP, Philibert M, Pouillaude JP, Pacros JP. Cholecystite aigue revelatrice de l'hepatite a virus A. Arch Fr Pediatr. 1985; 42:525-9. Google Scholar4. Lemon SM. Type A viral hepatitis. N Engl J Med. 1985; 313:1059-67. Google Scholar5. Shimizu YK, Shikata T, Beninger PR, Sata M, Setoyama H, Abe H, et al. Detection of hepatitis A antigen in human liver. Infect Immun. 1982; 36:320-4. Google Scholar6. Mathiesen LR, Drucker J, Lorenz D, Wagner J, Gerety JJ, Purcell RH. Localization of hepatitis A antigen in marmoset organs during acute infection with hepatitis A virus. J Infect Dis. 1978; 138:369-77. Google Scholar7. Karayiannis P, Jowett T, Enticott M, Moore M, Pignatelli M, Brenes F, et al. Hepatitis A virus replication in tamarins and host immune response in relation to pathogenesis of liver cell damage. J Med Virol. 1986; 18:261-76. Google Scholar8. Taylor GM, Goldin RD, Karayiannis P, Thomas HC. In situ hybridization studies in hepatitis A infection. Hepatology. 1992; 16:642-8. Google Scholar9. Fagan E, Yousef G, Brahm J, Garelick H, Mann G, Wolstenholme A, et al. Persistence of hepatitis A virus in fulminant hepatitis and after liver transplantation. J Med Virol. 1990; 30:131-6. Google Scholar10. Maudgal DP, Wansbrough-Jones MH, Joseph AE. Gallbladder abnormalities in acute infectious hepatitis. Dig Dis Sci. 1984; 29:257-60. Google Scholar Author, Article, and Disclosure InformationAuthors: Samir Mourani, MD; Stuart M. Dobbs, MD; Robert M. Genta, MD; Atul K. Tandon, PhD; Boris Yoffe, MDAffiliations: From the Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas; BioGenex Laboratories, San Ramon, California.Corresponding Author: Boris Yoffe, MD, Division of Digestive Diseases, 151B, Veterans Affairs Medical Center, 2002 Holcombe Boulevard, Houston, TX 77030.Acknowledgments: The authors thank Ms. Irene Bleyzer for technical assistance and Dr. Mary Estes for provision of HAV-infected cell lines.Grant Support: By grants from the Department of Veterans Affairs, by the American College of Gastroenterology, and by BioGenex Laboratories. Dr. Yoffe is a Scientific Consultant for BioGenex Laboratories and Dr. Tandon is a Manager of Research and Development for BioGenex Laboratories. 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Koch, MD, Harry C.M. van den Bosch, MD, and Bert Bravenboer, MD, PhDAcute acalculous cholecystitis as the initial presentation of primary Epstein-Barr virus infectionGallbladder Sludge and Acute Pancreatitis Induced by Acute Hepatitis AAcute Cholecystitis Complicating MumpsAn Unusual Cause of Acalculous Cholecystitis During Pregnancy: Hepatitis A VirusInfluence of load of hepatitis A virus on disease severity and its relationship with clinical manifestations in patients with hepatitis ACholécystite alithiasique révélant une hépatite aiguë au virus de l’hépatite AAcute Viral Cholecystitis Due to Hepatitis A Virus InfectionEndoscopic sonographic evaluation of the thickened gallbladder wall in patients with acute hepatitisThe Association of Hepatitis A Virus Infection, Acalculous Cholecystitis, and Blunt Abdominal Trauma: A Diagnostic ChallengeHepatitis A: Old and NewGallbladder and Pancreatic Involvement in Hepatitis AAcute viral hepatitis 1 March 1994Volume 120, Issue 5Page: 398-400KeywordsAntigensCellsEpitheliumGallbladderHepatitis AHepatitis A virusHepatocytesLiverPathogenesisResearch laboratories ePublished: 15 August 2000 Issue Published: 1 March 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. 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