tbuckley/cabot-search huggingface dataset:
Charles Brian McShane
Authors: Andrew Clarke
Journal: BMJ (2004)

Former medical officer Home Office Prison Service (b Barking 1928; q Queen's University, Belfast, 1953; DTM), died from heart disease on 28 November 2003.​2003.




Figure 1




Brian entered the Colonial Medical Service in Kenya after graduation and gained the diploma in tropical medicine while serving with the Royal Army Medical Corps. On his return to the United Kingdom he led the medical services for Portland prison, Dorset. The history of East Africa was one of his great passions and he combined his prison medical duties with examining students in tropical medicine from both Nairobi and Dundee universities. He leaves his second wife, Virginia, and three children from his first marriage.
Biased amino acid composition in repeat regions of Plasmodium antigens
Authors: F. Verra, A. L. Hughes
Journal: Molecular Biology and Evolution (1999)

Many malarial antigens contain extensive arrays of tandemly repeated short amino acid sequences, and much of the antibody response induced by malaria infections is directed against these repeats. Indeed, it has been hypothesized that these repeats function to elicit a relatively ineffective T-cell-independent antibody response by the host. In order to test this hypothesis, tandem repeats of Plasmodium species were examined for a bias in composition favoring amino acids likely to form epitopes for the antibody. The genome of Plasmodium is very A+T-rich, and nucleotide compositional bias will, in itself, lead to a high proportion of hydrophilic amino acids. When this bias was controlled for, Plasmodium antigens did not show a higher proportion of hydrophilic amino acids than expected, but there was a significant reduction in the proportion of hydrophobic amino acids in the repeats of the antigens. The amino acid composition of the repeats was thus strikingly different from those seen both in the remainder of the antigens and in a sample of Plasmodium falciparum housekeeping genes.
Canadian aboriginals in Vancouver face AIDS epidemic
Authors: D. Spurgeon
Journal: BMJ (2003)

HIV/AIDS is likely to become the next epidemic facing Canada's aboriginals, with aboriginal injecting drug users in Vancouver becoming infected at twice the rate among non-aboriginal injecting drug users in the city, a new study from the Canadian Medical Association Journal says (2003;168:19-24).

The reason for the higher rate of infection among aboriginal people seems to be related to the frequency with which they inject what are known as speedballs, a combination of cocaine and heroin.

Researchers at the British Columbia Centre for Excellence in HIV/AIDS and the University of British Columbia followed a cohort …
Private sector operations to rise from 4% to 11% of total
Authors: Zosia Kmietowicz
Journal: BMJ (2005)

The NHS is to more than double the number of operations it commissions in the private sector to help deliver the government's targets on waiting times, Patricia Hewitt, the new health secretary announced last week.

In her first speech in her new role, Ms Hewitt told delegates at an NHS managers conference that she was determined to carry on the pace of reform started by her predecessor, John Reid, to create a patient led health service. …
Overprescribing and Self-Medication — Hospital Discord — Every Little Bit Helps
Authors: John Lister
Journal: New England Journal of Medicine (1978)

IN a bid to reduce the National Health Service (NHS) drug bill Dr. James Cameron, chairman of the Council of the British Medical Association, has joined forces with Mr. David Ennals, Secretary of State for Social Services, in a campaign1 to halt the continual rise in the number of prescriptions issued through the NHS. In launching the campaign, which is directed toward doctors and patients alike, Mr. Ennals pointed out that the number of prescriptions issued has risen from 295 million in 1974 to 380 million in 1977. He believed that patient demand and drug advertising are the major causes . . .
A load adjusted performance index enhances prediction of temporal changes in left ventricular ejection fraction among asymptomatic patients with chronic nonischemic aortic regurgitation and initially normal resting function
Authors: Phyllis G. Supino, Jeffrey S. Borer, Clare A. Hochreiter, Edmund M. Herrold, Mary J. Roman, Richard B. Devereux, Paul Kligfield
Journal: Journal of the American College of Cardiology (2002)
Abstract A42: An albumin leader sequence coupled with a cleavage site modification enhances the yield of recombinant c-terminal Mullerian inhibiting substance
Authors: David Pepin, Mien Hoeng, Fotini Nicolaou, Katherine Hendren, Leo Benedict, Amanda Sosulski, Ahmad Al-Moujahed, Demetrious Vavvas, Patricia K. Donahoe
Journal: Clinical Cancer Research (2013)

Abstract Mullerian Inhibiting Substance (MIS) has been shown to inhibit ovarian cancer cells both in-vitro and in-vivo. MIS inhibits a putative ovarian cancer progenitor cell population enriched by a panel of CD44+, CD24+, Ep-CAM+, and E-cadherin- cell surface markers. In order to accommodate clinical testing of MIS in ovarian cancer patients, the production of recombinant human MIS must be optimized to increase yield and purity. Here, we show that the substitution of the MIS leader sequence to that of human serum albumin (HSAL), combined with a modification of the endogenous cleavage site from RAQR/S to a furin/kex2 RARR/S consensus site results in high expression, increased c-terminus cleavage and a reduction in unwanted cryptic internal cleavage products when produced in CHO cells. Purified MIS containing the HSAL modification displays increased potency to induce regression of the Mullerian duct in fetal rat embryonic urogenital ridge assays, reflecting the increased cleavage. The modifications herein described, which may be applicable to other TGF-beta family members, will facilitate production of active recombinant c-terminal MIS for clinical trials in ovarian cancer. Citation Format: David Pepin, Mien Hoeng, Fotini Nicolaou, Katherine Hendren, Leo Benedict, Amanda Sosulski, Ahmad Al-Moujahed, Demetrious Vavvas, Patricia K. Donahoe. An albumin leader sequence coupled with a cleavage site modification enhances the yield of recombinant c-terminal Mullerian inhibiting substance. [abstract]. In: Proceedings of the AACR Special Conference on Advances in Ovarian Cancer Research: From Concept to Clinic; Sep 18-21, 2013; Miami, FL. Philadelphia (PA): AACR; Clin Cancer Res 2013;19(19 Suppl):Abstract nr A42.
Bone-Marrow Aspiration and Biopsy
Authors: ARKADI M. RYWLIN
Journal: Annals of Internal Medicine (1975)

Comments and Correction1 August 1975Bone-Marrow Aspiration and BiopsyARKADI M. RYWLIN, M.D.ARKADI M. RYWLIN, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-83-2-282_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In a recent paper, "Bilateral Trephine Bone-Marrow Biopsies in Lymphoma and Other Neoplastic Diseases," (1) the authors state that "the superiority of bone-marrow biopsy over bone-marrow aspiration in defining extent of disease has been well established in Hodgkin's and non-Hodgkin's malignant lymphoma and carcinoma metastatic to bone marrow." A review of the quoted references shows that histologic sections were found to be superior to smears in evaluating the presence of malignant lymphoma or metastatic carcinoma in bone marrow. Histologic sections of bone marrow can be obtained by aspiration as well as biopsy. To the best of my...References1. BRUNNINGBLOOMFIELDMCKENNA RCR: Bilateral trephine bone-marrow biopsies in lymphoma and other neoplastic diseases. Ann Intern Med 82:365-366, 1975 LinkGoogle Scholar2. RYWLINMARVANROBINSON APM: A simple technic for the preparation of bone-marrow smears and sections. Am J Clin Pathol 53:389-393, 1970 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ARKADI M. RYWLIN, M.D.Affiliations: Department of Pathology and Laboratory Medicine Mount Sinai Medical Center of Greater Miami Miami Beach, Florida 33140 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1975Volume 83, Issue 2Page: 282-283KeywordsBiopsyBone marrowHodgkin lymphomaLymphoma ePublished: 1 December 2008 Issue Published: 1 August 1975 PDF downloadLoading ...
NOTE ON A PARACOLON BACILLUS FOUND IN THE URINE
Authors: W. Mair
Journal: BMJ (1906)

Hence the boiling witlh acid must be performed with care.7. The glycerose formned combines with one molecule of plienyl-hydrazine to form a hydrazone: CH20H CH20H CHOII + C6H, NII :NHi2 = CHOH + H20 pheniyl-hydrazine C/H CI~~~,/H \N,HC6H5 hydrazone.Then in the presencie of excess of phenyl-lhydrazine, time secondary alcohol group of the hydrazoiie is oxidized and another molecule of plhenyl-hydrazine is linked on, with the formationl of ani osazonie: CH120H CH20H CH2OH CHOHI C=O (-,=N 1.<,;H, /H I~6H H \N2HC6H, <\N2HCII \N2H.C6.H5.hydrazone.intermediate osazone.ketonic body.
Metabolism in Parkinsonian patients.
Authors: F. Carswill, I. W. Dymock
Journal: BMJ (1969)

known supraventricular arrhythmia prior to cardioversion.Eight patients had rheumatic disease of the mitral valve, with dominant stenosis in five cases, and dominant incompe- tence in three.Four patients had ischaemic heart disease, ten patients had arterial fibrilla- tion, and two had arterial flutter.All patients received premedication for cardiac catheterization, and it was reported that in most cases the behaviour of the mean systemic arterial pressure paralleled that of cardiac output, and no consistent change in peripheral resistance was observed.Such a comparison with healthy ambulatory patients undergoing routine conservation appears irregular, while the complete absence of controls during the investigation is open to criticism.Interpretation of Figs. 1 and 5 may depend on all or any of the following: timing, dose, solution strength of increment related to transient obstructions, operative stimuli, manual pressure on the tissues, and ineffective packing.The omission on a graph of one or more known synchronized variables, resulting in possible interpolation, can be misleading for future investigators.The inhalation of radiopaque materials may be irrelevant, as lung aspiration can occur in non-anaesthetized patients during sleep.3The observations on salivation conflict with the findings of Shafto,4 who expressed no trouble from this in 500 young patients anaesthetized with methohexitone.The data would suggest an incremental methohexitone technique pushed to the limit.Most experienced operators would have treatment planned to avoid it.With no reported morbidity following this investigation, there may be a compensatory factor at present obscure which may even highlight the inherent safety of methohexitone.-Iam, etc.,
"OPERATION FOR CORRECTION OF MILD CLAW-FOOT, THE RESULT OF INFANTILE PARALYSIS"
Authors: Hugh A. Thompson
Journal: JAMA (1926)

<h3>To the Editor:</h3> —Drs. Frank D. Dickson and Rex L. Diveley, who wrote on this subject (The Journal, October 16, p. 1275) seem to have devised a successful operation for this condition, and, being a clinician myself, I have only praise and admiration for anybody that perfects a cure for anything. My criticism of this article, therefore, is in the friendliest spirit and is made solely for the purpose of keeping physiology straight. In the opening paragraph appears the following statement: In all cases of claw-foot due to anterior poliomyelitis, there is weakness or paralysis of the flexor longus hallucis and the flexor longus digitorum, with overaction of the corresponding extensor tendons, resulting in prominence of the ball of the foot and the development of hammer toes. This seems to imply a false conception of the causative factor in the production of claw-foot. The action of the long toe flexors
Hypertension and raised serum lipids.
Authors: G W Thomas, J I Mann, L J Beilin, J G Ledingham, S Wynn
Journal: BMJ (1977)

Hypertension and raised serum lipidsAbout 30",, of patients seen in our lipid clinic during 1976 had raised blood pressure, and many patients attending the hypertension clinic have hyperlipidaemia.This apparent association between hyper- tension and hyperlipidaemia could have arisen because hypertensives tend to have lipid concentrations measured more frequently than people with no risk factors for vascular disease, or might have been due to treatment.We examined the association further by studying fasting lipid, glucose, and insulin concentrations in untreated hyper- tensives and in controls.
Role of interleukin 33 in human immunopathology
Authors: G E J Murphy, D Xu, F Y Liew, I B McInnes
Journal: Annals of the Rheumatic Diseases (2009)

Interleukin 33 (IL33) is a recently described member of the IL1 superfamily of cytokines. Originally defined on the basis of T-cell subset differentiation, IL33 is now recognised to mediate a wider role in regulating components of the innate immune response also, particularly via mast cell activation. In this paper the basic biology of IL33 is described together with that of its cognate receptor, ST2L, and the existing knowledge base for its potential role in mediating human pathology across a range of diseases is defined.
Citrullinated fibrinogen detected as a soluble citrullinated autoantigen in rheumatoid arthritis synovial fluids
Authors: Y Takizawa
Journal: Annals of the Rheumatic Diseases (2006)

<b>Background:</b> Anti-citrullinated protein antibodies (ACPA) are specifically and frequently detected in sera of patients with rheumatoid arthritis (RA). Citrullinated fibrin or fibrinogen is a candidate autoantigen of such antibodies. <b>Objective:</b> To investigate the presence of citrullinated fibrinogen (cFBG) in the plasma or synovial fluid of patients with RA and control patients, and to determine cFBG levels and their relationship with serum markers for RA if it is present. <b>Methods:</b> A sandwich enzyme linked immunosorbent assay (ELISA) to measure cFBG was established using monoclonal antibodies cF16.1 and cF252.1, generated by immunising mice with R16Cit and R252Cit, the fibrinogen Aα chain derived sequences with citrulline at position 16 and 252, respectively, and the presence of cFBG was further investigated with immunoprecipitation-western blotting. <b>Results:</b> Positive signals were detected in 11/15 RA synovial fluids (RASFs), but not in osteoarthritis synovial fluids or RA plasma with sandwich ELISA for cFBG using cF16.1 and an anti-modified citrulline (AMC) antibody. The presence of cFBG in RASFs was confirmed by immunoprecipitation-western blotting. Furthermore, most RA sera strongly reacted against R16Cit. No relationship was seen between RASF cFBG levels and C reactive protein or anti-cyclic citrullinated peptide antibody levels of the paired sera. <b>Conclusion:</b> cFBG is detected as a soluble citrullinated autoantigen in RASFs and may therefore be a genuine candidate antigen for ACPA in patients with RA.
Contrast-associated nephropathy and clinical outcome of patients with chronic renal insufficiency undergoing cardiac catheterization: Lack of additive benefit of acetylcysteine to saline hydration
Authors: Ilan Goldenberg, Michael Jonas, Shlomi Matetzki, Michael Shechter, Oren Agranat, Yedael Har-Zahav, Dan Elian, Victor Guetta
Journal: Journal of the American College of Cardiology (2003)
LIMITATIONS IN DENTAL EDUCATION.
Authors: EUGENE S. TALBOT
Journal: JAMA (1900)

In dealing with limitations in dental education, we are brought face to face with their greatest evil—di-divorcement of dental from medical teaching. Removal of a special department from general medicine and tuition along narrow lines have so narrowed teaching that even diseases of the general system which affect the mouth, jaws and teeth are excluded. The medical profession has been content to let the dentist entirely alone. In studying systemic diseases, therefore, it has not trespassed on the field of dentistry. The result is that study of the general diseases which affect the mouth, jaws and teeth have been neglected. Limitations of a dental education have prevented the dentist from associating local diseases with systemic causes. The very title, "Doctor of Dental Surgery," has so closely and exclusively limited the profession, as it is called, that the dentist is known by the laity as doctor of the teeth. A letter
A Telephone- and Text Message-Based Telemedicine Concept for Patients with Mental Health Disorders: Results of a Randomized Controlled Trial
Authors: Neeltje van den Berg, Hans-Jörgen Grabe, Sebastian E. Baumeister, Harald J. Freyberger, Wolfgang Hoffmann
Journal: Psychotherapy and Psychosomatics (2015)

Background: A telemedicine care concept based on telephone contacts and individualized text messages was developed for patients with mental disorders to continue treatment after therapy in a psychiatric day hospital. The primary objective of this study was to evaluate the effectiveness of the telemedicine interventions. Methods: The study had a 3-armed, randomized design with 2 intervention arms (intervention 1: telephone contacts; intervention 2: telephone contacts and short text messages; both took place over a period of 6 months and in addition to usual care), and a control group with usual care. Primary outcomes were 18-item Brief Symptom Inventory (BSI-18) scores for anxiety, depression and somatization. All participants were recruited from psychiatric day hospitals. The study was registered in the German Clinical Trials Register (DRKS00000662). Results: 113 participants were analyzed 6 months after starting the intervention. The average BSI-18 anxiety score after 6 months was -2.04 points lower in intervention group 2 than in the control group (p value: 0.042). The difference in BSI depression score between these two groups was marginally significant (p value: 0.1), with an average treatment effect of -1.73. In an exploratory sensitivity analysis restricted to the 75% of patients with the highest symptom scores at baseline, intervention group 1 yielded a significant effect for anxiety and depression compared to the control group (p = 0.036 and 0.046, respectively). Conclusions: Telemedicine provides a novel option in psychiatric ambulatory care with statistically significant effects on anxiety. A positive tendency was observed for depression, especially in cases with higher symptom load at baseline. © 2015 S. Karger AG, Basel.
Extended preservation of rat liver graft by induction of heme oxygenase-1
Authors: Claudio A. Redaelli, Ying-Hua Tian, Thomas Schaffner, Monika Ledermann, Hans U. Baer, Jean-François Dufour
Journal: Hepatology (2002)

Livers can be preserved only for a short period without jeopardizing the transplantation outcome. Heat shock proteins (HSPs) protect against ischemia and reperfusion injury. We studied whether their induction and, in particular, the induction of heme oxygenase 1 (HO-1), improves transplantation survival after an extended time of cold storage. Rats were subjected to heat preconditioning (42°C for 20 minutes). Livers were harvested 24 hours later, preserved in cold University of Wisconsin solution for 44 hours, and transplanted in isogeneic rats (arterialized transplantation). HO-1 was specifically induced and inhibited by cobalt protoporphyrin and tin protoporphyrin, respectively. All animals receiving a graft without preconditioning and subjected to 44 hours of cold preservation died within 3 days, whereas 89% of rats who received a graft exposed to heat survived for 3 weeks ( P = .0004). Preconditioning reduced serum aspartate transaminase (AST) and lactate dehydrogenase activities after reperfusion, improved bile flow, and decreased the histologic lesions of reperfusion injury. These significant effects of heat preconditioning were prevented by administration of tin protoporphyrin and could be reproduced by administration of cobalt protoporphyrin. In grafts without preconditioning, only a small fraction (&lt;5%) of hepatocytes were positive with the terminal deoxynucleotide transferase-mediated dUTP nick-end labeling (TUNEL) assay, and even less expressed activated caspase 3. Preconditioning tended to reduce the number of positive cells and to stimulate the expression of antiapoptotic Bcl-X L . In conclusion, heat preconditioning and, specifically, overexpression of HO-1 improve posttransplantation survival and graft function after prolonged cold ischemia preservation. The mechanism underlying these beneficial effects does not appear to be prevention of apoptosis.
L. DUNCAN BULKLEY AND CANCER
Authors: Henry H. Whitehouse
Journal: JAMA (1924)

<h3>To the Editor:</h3> —InThe Journal, April 19, p. 1285, there is a letter from Dr. Albert G. Hulett concerning Dr. L. Duncan Bulkley's cancer treatment. This letter gives the impression that he is, at present, conducting a "medical" cancer clinic in the Skin and Cancer Hospital. Regarding Bulkley's extravagant claims, the previous secretary of the medical board of the Skin and Cancer Hospital, Dr. George Semken, repudiated all his claims and pretensions in two letters, published inThe Journal, June 23, 1923, p. 1867, and Oct. 22, 1921, p. 1357. Dr. Bulkley asserted that he held the position of senior physician. There is no such position in the Skin and Cancer Hospital. In the last annual report, Dr. Bulkley is down as dermatologist emeritus. It is a number of years since Dr. Bulkley had a clinic in the hospital, and then it was related to general dermatology; that was
THE SALIVARY CURVE: A PSYCHIATRIC THERMOMETER ?
Authors: GEORGE F. SUTHERLAND
Journal: American Journal of Psychiatry (1959)

The method offers a most promising field of investigation for those who are prepared to invest the time and effort to learn the technique. It seems reasonable to anticipate that a considerable saving in time could be effected, for example, in the testing of therapeutic procedures by having recourse to an objective measure rather than impressions that rely upon statistical analysis for verification. It might be mentioned that one "sputnik" is more convincing than all the statistical evidence in the world. At least one of the more venturesome pharmaceutical companies has already taken advantage of the motor conditional reflex in rats in arriving at suggested doses for each of its new tranquilizers. It is interesting to reflect that the medical profession accept the findings of the drug manufacturers obtained by a less precise method by comparison, yet seem reluctant to explore a much more exact technique in the clinical application of the drugs themselves.