tbuckley/cabot-search huggingface dataset:
Phase I Trial of Multiple Large Doses of Murine Monoclonal Antibody CO17-1A. I. Clinical Aspects1
Authors: A. F. LoBuglio, M. N. Saleh, J. Lee, M. B. Khazaeli, R. Carrano, H. Holden, R. H. Wheeler
Journal: JNCI Journal of the National Cancer Institute (1988)

Journal Article Phase I Trial of Multiple Large Doses of Murine Monoclonal Antibody CO17-1A. I. Clinical Aspects1 Get access Albert F. LoBuglio, Albert F. LoBuglio * 3Comprehensive Cancer Center, University of Alabama at BirminghamBirmingham, AL *Dr. Albert F. LoBuglio, Comprehensive Cancer Center, University of Alabama at Birmingham, 237 Tumor Institute, University Station, Birmingham, AL 35294. Search for other works by this author on: Oxford Academic PubMed Google Scholar Mansoor N. Saleh, Mansoor N. Saleh 3Comprehensive Cancer Center, University of Alabama at BirminghamBirmingham, AL4Veterans Administration Medical CenterBirmingham Search for other works by this author on: Oxford Academic PubMed Google Scholar Jeannette Lee, Jeannette Lee 3Comprehensive Cancer Center, University of Alabama at BirminghamBirmingham, AL Search for other works by this author on: Oxford Academic PubMed Google Scholar M. B. Khazaeli, M. B. Khazaeli 3Comprehensive Cancer Center, University of Alabama at BirminghamBirmingham, AL4Veterans Administration Medical CenterBirmingham Search for other works by this author on: Oxford Academic PubMed Google Scholar Richard Carrano, Richard Carrano 5Centocor, Inc. Malvern, PA Search for other works by this author on: Oxford Academic PubMed Google Scholar Howard Holden, Howard Holden 5Centocor, Inc. Malvern, PA Search for other works by this author on: Oxford Academic PubMed Google Scholar Richard H. Wheeler Richard H. Wheeler 3Comprehensive Cancer Center, University of Alabama at BirminghamBirmingham, AL Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 80, Issue 12, 17 August 1988, Pages 932–936, https://doi.org/10.1093/jnci/80.12.932 Published: 17 August 1988 Article history Received: 07 March 1988 Revision received: 10 May 1988 Accepted: 11 May 1988 Published: 17 August 1988
Treatment of Morphine-Type Dependence
Authors: Herbert A. Raskin
Journal: JAMA (1972)

<h3>To the Editor.—</h3> As indicated by Dr. Chappel, "Treatment of Morphine-Type Dependence by Withdrawal Methods" is a definitive statement by the AMA. It should be stressed, however, that these guidelines should be interpreted flexibly and should not substitute for thorough clinical evaluation of each individual patient with appropriate application of the guidelines. The following relate to Dr. Chappel's specific comments: The Committee agrees that deep aches are a common symptom of withdrawal from methadone. All symptoms of opioid withdrawal may be seen in withdrawal from methadone, but they tend to be less intense and more prolonged than those seen in withdrawal from the shorteracting opioids. Insomnia and tension are among those symptoms commonly seen, but when they are protracted over a period of several months and are fluctuating in nature, underlying psychic factors must be considered. Many schedules of withdrawal are possible and medically proper, including that suggested
More than 90% of mothers with HIV fail to get help to stop their babies being born HIV positive
Authors: Oona Mashta
Journal: BMJ (2007)

The UK government should financially support the health services of developing countries to provide the drugs and care that pregnant, HIV positive women need to stop them passing the infection to their babies, a new Unicef report urges.

More than 90% of pregnant, infected women in poor countries miss out on services that could prevent their babies being born with the disease, the report says. 

Every minute a baby is born with HIV, most of whom are destined to die before their second birthday, yet the risk of mothers passing HIV to their babies can be …
CORRIGENDUM: Glycan and lectin microarrays for glycomics and medicinal applications
Authors: Jaroslav Katrlík, Juraj Švitel, Peter Gemeiner, Tibor Kožár, Jan Tkac
Journal: Medicinal Research Reviews (2010)

An incorrect version of Table I appeared in the print and pdf versions of this article in issue 30(2). The correct Table I appears on the following pages. We regret any inconvenience this may have caused.
Identification of a major GpVI-binding locus in human type III collagen
Authors: Gavin E. Jarvis, Nicolas Raynal, Jonathan P. Langford, David J. Onley, Allen Andrews, Peter A. Smethurst, Richard W. Farndale
Journal: Blood (2008)

We have analyzed the adhesion of human and murine platelets, and of recombinant human and murine GpVI ectodomains, to synthetic triple-helical collagen-like peptides. These included 57 peptides derived from the sequence of human type III collagen and 9 peptides derived from the cyanogen bromide fragment of bovine type III collagen, alpha1(III)CB4. We have identified several peptides that interact with GpVI, in particular a peptide designated III-30 with the sequence GAOGLRGGAGPOGPEGGKGAAGPOGPO. Both human and murine platelets bound to peptide III-30 in a GpVI-dependent manner. III-30 also supported binding of recombinant GpVI ectodomains. Cross-linked III-30 induced aggregation of human and murine platelets, although with a lower potency than collagen-related peptide. Modifications of the peptide sequence indicated that the hydroxyproline residues play a significant role in supporting its GpVI reactivity. However, many peptides containing OGP/GPO motifs did not support adhesion to GpVI. These data indicate that the ability of a triple-helical peptide to bind GpVI is not solely determined by the presence or spatial arrangement of these OGP/GPO motifs within the peptides.
GASTROCAMERA STUDIES IN ROSACEA
Authors: LIONEL FRY, J. C. SWANN
Journal: British Journal of Dermatology (1968)

SUMMARY.— Ten patients with rosacea were examined with the gastro‐camera. No abnormality of the gastric mucosa was found. Gastric biopsy in 5 of the patients showed no histological abnormality and histochemically the succinic dehydrogenase content of the parietal cells was also normal.
Prevalence of factor V Leiden among women with pulmonary embolism or deep vein thrombosis during pregnancy or oral contraceptive use
Authors: Denise R. Hirsch, Katrina M. Mikkola, Peter W. Marks, Edward A. Fox, David M. Dorfman, Bruce M. Ewenstein, Samuel Z. Goldhaber
Journal: Journal of the American College of Cardiology (1996)
GW25-e2175 Reduced Desensitization of Angiotensin II-1 Receptor on Rat Thoracic Aortic Vascular Smooth Muscle Caused by Autoantibodies against Angiotensin II-1 Receptor and the Underlying Mechanisms
Authors: Zhang Huijun, Liu Huirong
Journal: Journal of the American College of Cardiology (2014)
Effect of a Multivitamin and Mineral Supplement on Infection and Quality of Life
Authors: Thomas A. Barringer, Julienne K. Kirk, Amy C. Santaniello, Kristie Long Foley, Robert Michielutte
Journal: Annals of Internal Medicine (2003)

Background: Use of multivitamin and mineral supplements is common among U.S. adults, yet few well-designed trials have assessed the reputed benefits. Objective: To determine the effect of a daily multivitamin and mineral supplement on infection and well-being. Design: Randomized, double-blind, placebo-controlled trial. Setting: Primary care clinics at two medical centers in North Carolina. Participants: 130 community-dwelling adults stratified by age (45 to 64 years or 65 years) and presence of type 2 diabetes mellitus. Intervention: Multivitamin and mineral supplement or placebo taken daily for 1 year. Measurements: Incidence of participant-reported symptoms of infection, incidence of infection-associated absenteeism, and scores on the physical and mental health subscales of the Medical Outcomes Study 12-Item Short Form. Results: More participants receiving placebo reported an infectious illness over the study year than did participants receiving multivitamin and mineral supplements (73% vs. 43%; P < 0.001). Infection-related absenteeism was also higher in the placebo group than in the treatment group (57% vs. 21%; P < 0.001). Participants with type 2 diabetes mellitus (n = 51) accounted for this finding. Among diabetic participants receiving placebo, 93% reported an infection compared with 17% of those receiving supplements (P < 0.001). Medical Outcomes Study 12-Item Short Form scores did not differ between the treatment and placebo groups. Conclusions: A multivitamin and mineral supplement reduced the incidence of participant-reported infection and related absenteeism in a sample of participants with type 2 diabetes mellitus and a high prevalence of subclinical micronutrient deficiency. A larger clinical trial is needed to determine whether these findings can be replicated not only in diabetic persons but also in any population with a high rate of suboptimal nutrition or potential underlying disease impairment.
Characterization of Plaque Components With Intravascular Ultrasound Elastography in Human Femoral and Coronary Arteries In Vitro
Authors: Chris L. de Korte, Gerard Pasterkamp, Anton F. W. van der Steen, Hein A. Woutman, Nicolaas Bom
Journal: Circulation (2000)

The composition of plaque is a major determinant of coronary-related clinical syndromes. Intravascular ultrasound (IVUS) elastography has proven to be a technique capable of reflecting the mechanical properties of phantom material and the femoral arterial wall. The aim of this study was to investigate the capability of intravascular elastography to characterize different plaque components.Diseased human femoral (n=9) and coronary (n=4) arteries were studied in vitro. At each location (n=45), 2 IVUS images were acquired at different intraluminal pressures (80 and 100 mm Hg). With the use of cross-correlation analysis on the high-frequency (radiofrequency) ultrasound signal, the local strain in the tissue was determined. The strain was color-coded and plotted as an additional image to the IVUS echogram. The visualized segments were stained on the presence of collagen, smooth muscle cells, and macrophages. Matching of elastographic data and histology were performed with the use of the IVUS echogram. The cross sections were segmented in regions (n=125) that were based on the strain value on the elastogram. The dominant plaque types in these regions (fibrous, fibro-fatty, or fatty) were obtained from histology and correlated with the average strain and echo intensity. The strain for the 3 plaque types as determined by histology differed significantly (P=0.0002). This difference was mainly evident between fibrous and fatty tissue (P=0.0004). The plaque types did not reveal echo-intensity differences in the IVUS echogram (P=0.882).Different strain values are found between fibrous, fibro-fatty, and fatty plaque components, indicating the potential of intravascular elastography to distinguish different plaque morphologies.
A mobile surgery for single homeless people in London.
Authors: S. S. Ramsden, P. Nyiri, J. Bridgewater, D. J. el-Kabir
Journal: BMJ (1989)

Little is known about the social and medical characteristics of people who regularly sleep rough, or whether medical care can be targeted at these people. In 1987 a mobile surgery was used to provide primary health care at two sites in central London where many single homeless people sleep outdoors. One hundred and forty six patients were seen with illnesses ranging from scabies to osteomyelitis and tuberculosis. Sociodemographic data showed the patients to be generally an isolated group with deprived and unstable backgrounds, often compounded by alcohol abuse. Over a third of the patients from one site attended a drop in surgery for homeless people in Soho within a month after seeing a doctor in the mobile surgery. This suggests that the project can be a first step in integrating this isolated group with health care facilities.
Abstract 1993: Higher activity of cell proliferation is associated with poor survival in lung adenocarcinoma
Authors: Jo-Yang Lu, Tzu-Hung Hsiao, Konan Peck, Eric Y. Chuang, Liang-Chuan Lai
Journal: Cancer Research (2010)

Abstract The number of patients with lung adenocarcinoma, a major histological type of lung cancer, has soared recently. Although some lung adenocarcinoma patients could be diagnosed at early stages and received surgical resection, nearly 50% of patients still died from recurrence. This phenomenon indicates that using only traditional prognostic factors, like TMN staging, is not sufficient for regimen decision. Here we proposed a bioinformatic method to evaluate the activity of cell cycle from expression profiles and proved that the activity of cell cycle can be applied as prognostic factor of lung adenocarcinoma, especially for early stages. A gene set named as cell cycle signature (CCS), which correlated with cell cycling, was used to measure the activity of tumor proliferation. The E2F1 target genes and E2F3 target genes were also applied to measure the E2F signaling pathway activity, which was regulated by the cell cycle. The prognostic ability of these gene sets was evaluated by applying Cox hazard proportional analysis to three microarray datasets of lung adenocarcinoma. Our result revealed that the association between high activities of cell cycle and poor survival outcomes existed in lung adenocarcinoma patients. The result of Cox hazard proportional analysis showed that the CCS and E2F1/E2F3 target genes are significant contributors to survival risk. The p-values of CCS, E2F1/E2F3 target genes were all showed significant (p&amp;lt;0.05), and these three gene sets still gave statistical significances after the survival analysis was applied on only early stage lung adenocarcinoma. The hazard ratios of CCS, E2F1 target genes and E2F3 target genes were 5.69, 3.32, and 3.96, respectively; all p-values were smaller than 0.002. We demonstrated that the three gene sets, which accountable for the activity of cell cycle, can be applied as prognostic factors for lung adenocarcinoma, including early stage patients. Our data inferred that tumor with higher activity of proliferation is malignant eventhough its size may still be small. This finding is valuable in predicting the survival of early stage lung adenocarcinoma patients and might be useful for making treatment decisions. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1993.
Fine specificity of serum anticollagen molecules in experimental immune synovitis.
Authors: T F Kresina, I A Rosner, V M Goldberg, R W Moskowitz
Journal: Annals of the Rheumatic Diseases (1985)

Serum anticollagen antibodies to the native and denatured interstitial collagens were measured by solid phase radioimmunoassay (RIA) in a rabbit model of IgG-induced immune synovitis. Serum antibodies binding the native interstitial collagens and denatured type II collagen were observed in 100% of the animals tested (n = 6). Titerable antibodies to the alpha 1 (III) collagen polypeptide chain were observed in 83% of the animals, whereas serum antibodies to denatured type I collagen were observed in 33%. Inhibition studies showed that the observed serum anticollagen antibodies were conformationally dependent and collagen type specific. In addition these antibody populations varied in their affinities by as much as a factor of 2.81 for the specific substrates. Mean value of the average binding constants (Ka) for synovitis anticollagen antibodies binding native type II collagen was 5.47 X 10(6)mol; while the Ka determined for synovitis antibodies binding denatured type III collagen was 1.94 X 10(6)/mol. The data indicate that unique anticollagen antibody populations are expressed in the serum of animals with experimental IgG-induced chronic immune synovitis.
Prediction and Prognostication in Coronary Heart Disease
Authors: Henry Blackburn
Journal: New England Journal of Medicine (1974)

The physician is frequently asked these simple and seemingly innocuous questions: "Does emotional stress bring on heart attacks?" "Is coffee drinking bad for you?" "Is exercise good for you?" "Which coronary risk factor is the most important?" Such cocktail-hour questions from patients, colleagues and friends are among the more difficult in medicine to answer with assurance.Approaches to the scientific study of questions about coronary risk are illustrated in two articles contained in this issue, one by Friedman and his co-authors on the total leukocyte count, and one by Jenkins et al. about answers to a behavioral questionnaire, both in . . .
"Primary Myxoedema" in a Man of 30
Authors: F. R. M. Young
Journal: BMJ (1955)

Since this paper was written a case of this syndrome associated with hypertrophic pyloric stenosis has been recognized in a 2-months-old infant (Keay and Lewis, 1954).These authors, however, described bthe oedema of the extremities in their patient as non-pitting in character.
Understanding the temporal relationship of ATP loss, calcium loading, and rigor contracture during anoxia, and hypercontracture after anoxia in cardiac myocytes
Authors: D Stowe
Journal: Cardiovascular Research (1999)

See article by Ladilov et al. [9] (pages 408–416) in this issue. 

Much research effort has been directed toward understanding the pathogenesis of cardiac ischemia reperfusion injury and developing methods to ameliorate the degree of damage. The interesting discover by Murry et al., reported 13 years ago, that a brief period of ischemia and reperfusion can partially protect the heart from reperfusion damage after a subsequent period of ischemia has sparked intense interest in the area of cardioprotection [1]. Hans Michael Piper and his collaborators, working mostly at the University of Dusseldorf and Justus-Liebig University, have contributed substantially to our knowledge of the pathophysiology of ischemia and reperfusion. They are mostly using a model of simulated ischemia (anoxia, acidosis, and substrate depletion) in which cell shortening of isolated cardiomyocytes during anoxia (rigor contracture) and during re-oxygenation (hypercontracture) are measured temporally with indices of metabolism and myocyte ion concentrations. They have proposed that the increase in contracture on re-oxygenation (hypercontracture) leading to cell injury (oxygen paradox) is due to the occurrence of Ca2+ overloading at the time of ATP repletion (calcium paradox) [2,3].

More recently, Yury V. Ladilov, working with Dr. Piper and others, have begun to better understand the mechanisms of myocyte dysfunction during and after simulated ischemia and the pathways by which dysfunction can be reduced by treatments applied before simulated ischemia. In recent studies they have examined carefully the importance of Na+ H+ exchange and reverse Na+ Ca2+ exchange in causing Na+ and Ca2+ loading as contributing to myocyte contracture and its reduction by acidosis and Na+ H+ exchange inhibition [4,5].

Protein kinase C (PKC) activation and translocation occur during ischemic preconditioning and activation of specific PKC isoforms has been found to be an important link …
THE INTERRELATION OF NEUROLOGY, PSYCHIATRY AND PSYCHOANALYSIS
Authors: ROY R. GRINKER
Journal: JAMA (1941)

The relationship of clinical neurology, psychiatry and psychoanalysis as specialties of medical practice is not clearly understood by the lay public or by the medical profession. These fields are thought of sometimes as sharply isolated, are often confused with one another, or are considered together as one special branch of medicine. I consider that they are intimately interrelated, and my thesis is that the future progress of all three in practice and research is dependent on a diffusion through the artificial boundaries of the fundamental principles, methodologies and recognized facts of each. The integrated neuropsychiatry that results will be a legitimate member of the medical sciences broad enough to include normal and abnormal psychology hitherto largely ignored by medicine. By accepted definition, clinical neurology is that branch of medicine concerned with the investigation, methods of examination, diagnosis and treatment of organic diseases of the nervous system. Its technics, although specialized,
A CASE OF DOUBLE PERFORATING GASTRIC ULCER
Authors: L. L. Keays
Journal: BMJ (1903)

DOUBLE PERFORATING GASTRIC ULCER. 1 Z459 aged 52.The cut ends of the oesophagus and duodenum wete closed by suture, and a lateral anastomosis made between the *oesophagus and a loop of small intestine.The patient was alive nine mnonths later.[This case is, perhaps, open to question.A lateral anastomosis with a normal oesophagus
Psychological medicine. Schizophrenia and related paranoid psychoses.
Authors: P F Kennedy
Journal: BMJ (1975)

This paper considers the treatment of schizophrenia and those conditions called paranoid states. The latter include patients with delusions of a fairly fixed, elaborated kind, often with hallucinations, who do not show the same degree of personality deterioration as is found in the course of schizophrenia. The older the patient the more often paranoid state is diagnosed in preference to schizophrenia, but the relationship between these types of psychosis is not well understood. However, modern methods of treatment have much in common.
Distribution of cardiac output, oxygen consumption and lactate production in canine endotoxin shock
Authors: A A VAN LAMBALGEN, W BRONSVELD, G C VAN DEN BOS, L G THIJS
Journal: Cardiovascular Research (1984)

Endotoxin causes shock accompanied by compensatory changes such as redistribution of cardiac output and increased oxygen extraction. We studied these effects in anaesthetised dogs (etomidate: 4 mg X kg-1 X h-1, n = 14) randomly assigned to a control (n = 6) and a shock group (endotoxin 1.5 mg X kg-1; n = 8). We measured left ventricular pressure, LVEDP and LVdP/dt (Millar microtip), mean systemic, central venous and pulmonary artery pressure (Statham P23Db), cardiac output (thermodilution), organ flow (microspheres, 15 micron, 5 labels), bloodgases (PO2, PCO2), pH and lactate. All measurements were performed before and at 60, 90, 120 and 150 min after endotoxin or saline. Sixty minutes after endotoxin mean systemic pressure, LVdP/dt and cardiac output had decreased (by 60, 50 and 35%), while heart rate had increased (by 30%). Arterial PO2 was lower after endotoxin (-29%), haematocrit and mixed venous PCO2 were higher (+16 and +38%) and arterial pH had decreased from 7.34 to 7.14. After endotoxin perfusion of heart and adrenals did not change but muscle perfusion increased (by 33% at t = 90). Endotoxin caused vasoconstriction in spleen and kidneys: the percentage of cardiac output to these organs thus decreased (by 50 and 69%). Sixty minutes after endotoxin we found vasodilatation in the hepatic arterial, pancreatic, and gastrointestinal beds. Later the percentage of cardiac output to these beds decreased. Systemic arterio-venous shunting fell (from 6.5 to 0.7%). Systemic and splanchnic oxygen extraction increased (by 66 and 71% at t = 60): oxygen consumption hardly changed; 60 min after endotoxin it tended to decrease. During shock serum lactate rose (by 167% at t = 60) before oxygen consumption fell. Myocardial oxygen consumption did not alter during shock but the tension time index decreased.
POST-ISCHEMIC MYOCARDIAL STUNNING IS SUPERIOR TO TRANSIENT ISCHEMIC DILATION TO DETECT MULTI-VESSEL CORONARY ARTERY DISEASE
Authors: Satoshi Hida, Taishiro Chikamori, Hirokazu Tanaka, Yuko Igarashi, Chie Shiba, Yasuhiro Usui, Tsuguhisa Hatano, Akira Yamashina
Journal: Journal of the American College of Cardiology (2011)