tbuckley/cabot-search huggingface dataset:
Hepatitis B vaccine continues to provide long-term protection to healthcare workers
Authors: Steven T. Wiersma
Journal: Journal of Hepatology (2009)

Boot et al. describe a case of hepatitis B vaccination failure in a healthcare worker [[1]Boot H.J. van der Waaij L.A. Schirm J. Kallenberg C.G.M. van Steenbergen J. Wolters B. Acute hepatitis B in a healthcare worker: a case report of genuine vaccination failure.J Hepatol. 2009; 50: 426-431Abstract Full Text Full Text PDF PubMed Scopus (31) Google Scholar]. According to this report, the case belongs to two risk groups for hepatitis B virus (HBV) infection: healthcare workers and male homosexuals. The report presents a history of unsafe sex with at least five male partners in the six months prior to the acute infection and no details about occupational exposures. In addition, the molecular epidemiology is that of a HBV isolate prevalent among men who have sex with men (MSM) in the Netherlands. The authors state that "Healthcare workers [HCWs] whose response to the initial hepatitis B vaccination is moderate might be vulnerable to hepatitis B virus infection". However, this case report is not about occupationally acquired hepatitis B infection but rather about sexually transmitted infection from sexual exposure. Furthermore, there are host factors that indicate some immunological dysfunction. The patient had "responded only marginally" to his primary vaccination series (anti-HBs = 10 sample ratio units). In addition, the patient had a reverse CD4:CD8 ratio with decreased T-cell responsiveness against mitogens. Hepatitis B vaccine provides at least 15 years of protection, as demonstrated in a randomized controlled trial of children vaccinated at birth [[2]van der Sande M.A. Waight P. Mendy M. Rayco-Solon P. Hutt P. Fulford T. et al.Long-term protection against carriage of hepatitis B virus after infant vaccination.J Infect Dis. 2006; 193: 1528-1535Crossref PubMed Scopus (111) Google Scholar], and at least 10 years of protection in HCWs [[3]Floreani A. Baldo V. Cristofoletti M. Renzulli G. Valeri A. Zanetti C. et al.Long-term persistence of anti-HBs after vaccination against HBV: an 18 year experience in health care workers.Vaccine. 2004; 22: 608-611Crossref Scopus (115) Google Scholar]. Policy makers should continue to be vigilant about the potential for breakthrough infections, however, they should also remain assured of the excellent performance of this vaccine in the occupational health setting. Behavior change should continue to be seen as an important protective measure in MSM, especially when immune dysfunction could blunt the response to vaccination.
Molecular definition and sequence motifs of the 52-kD component of human SS-A/Ro autoantigen.
Authors: E K Chan, J C Hamel, J P Buyon, E M Tan
Journal: Journal of Clinical Investigation (1991)

Serum SS-A/Ro autoantibodies are commonly found in patients with Sjogren's syndrome, systemic lupus erythematosus, neonatal lupus, and subacute cutaneous lupus. Two proteins of 60 and 52 kD have been described as targets for these autoantibodies. To define the 52-kD component unambiguously, cDNA clones were isolated from human HepG2 and MOLT-4 cell cDNA libraries. The identity of cDNA was established by (a) the specificity of the antibody affinity purified from the recombinant protein, (b) the reactivity of the purified recombinant protein with prototype SS-A/Ro sera in immunoblot and ELISA, and (c) two-dimensional gel comigration of MOLT-4 cell 52-kD protein and the recombinant protein. A 1.9-kb cDNA encoded the complete 52-kD protein containing 475 amino acids (Mr 54,082). Putative zinc-finger domains and a leucine zipper motif were identified in the amino-terminal half of the 52-kD protein, implicating its possible association with DNA/RNA. Sequence homology detected between the 52-kD protein and human ret transforming protein, and mouse T cell gene expression down-regulatory protein rpt-1, may provide leads to the functional role of the 52-kD protein in addition to the possibility that these proteins might constitute members of a subfamily of finger proteins.
Sucralfate-formed esophageal bezoar detected following sudden vomiting
Authors: Y. Kise, R. Aihara, O. Chino, S. Yamamoto, T. Hara, T. Nishi, T. Kenmochi, H. Shimada, H. Makuuchi
Journal: Endoscopy (2006)

We report a rare case of esophageal bezoar, thought to have formed after oral intake of sucralfate. A 62-year-old man, who was wheelchair-bound due to paralysis of both lower limbs following surgery for a spinal tumor, and with a history of partial gastrectomy for gastric ulcer, was diagnosed with cancer of the pancreatic head. The patient refused any treatment apart from symptomatic care.
Ectopic expression of decorin protein core causes a generalized growth suppression in neoplastic cells of various histogenetic origin and requires endogenous p21, an inhibitor of cyclin-dependent kinases.
Authors: M Santra, D M Mann, E W Mercer, T Skorski, B Calabretta, R V Iozzo
Journal: Journal of Clinical Investigation (1997)

Decorin belongs to a family of secreted, small, leucine-rich proteoglycans that affect matrix assembly and cellular growth. Ectopic expression of decorin proteoglycan or protein core as a mutated form lacking any glycosaminoglycan side chains induced growth suppression in neoplastic cells of various histogenetic origins, including tumor cells derived from gastrointestinal, genital, skeletal, cutaneous, or bone marrow tissues. Exogenously added recombinant decorin also suppressed overall growth of the parental cell lines. In all stably-transfected clones, growth retardation was specifically associated with induction of the potent cyclin-dependent kinase inhibitor p21, but not p27, and subsequent translocation of p21 protein into the nuclei of decorin-expressing cells. This led to a greater proportion of the cells arrested in G1 phase of the cell cycle. These changes were independent of functional p53 or retinoblastoma protein. De novo expression of decorin in HCT116 human colon carcinoma cells harboring a disrupted p21 gene failed to induce growth suppression, in contrast to the wild-type cells in which p21 and growth arrest could be induced. These findings indicate that ectopic production of decorin protein core can retard the growth of a variety of tumor cells and that endogenous p21 is a required downstream effector of this biological axis.
Emergency Radiology of the Acutely III or Injured Child
Authors: Terrence S. Carden
Journal: JAMA (1979)

The author promises in his introduction to concentrate on evaluation of the plain film, which is a mainstay of diagnosis in emergency medicine. In general, he holds true to his promise but cannot resist the temptation to include examples of computerized axial tomography used in the assessment of the condition of an emergency patient. For this he can be forgiven, since the number, clarity, and relevance of his other illustrations are genuinely helpful to the practitioner of emergency medicine. Particularly relevant are his discussion and illustrations of typical traumatic injuries to the extremities, spine, and head—the bread and butter of emergency medicine. Recent risk-factor analyses of emergency medical practices indicate that the most common claim against emergency physicians involves missed fractures. No competent emergency physicians would be expected to overlook a fracture of serious clinical importance. However, when interpreting scores of extremity, spine, and skull films during a night's duty
Complement Inhibitors And Glomerulonephritis
Authors: William G. Couser
Journal: Journal of the American Society of Nephrology (2003)

I recently gave a talk at a European nephrologic gathering on future therapies for glomerulonephritis (GN). It relied heavily on data from established animal models of renal disease. At the end, the first comment came from a very stern and unhappy-looking clinical nephrologist at the back of the
Effects of intradermally injected leukotriene C4 and histamine in patients with urticaria, psoriasis and atopic dermatitis
Authors: LENNART JUHLIN, SVEN HAMMARSTROM
Journal: British Journal of Dermatology (1982)

Journal Article Effects of intradermally injected leukotriene C4 and histamine in patients with urticaria, psoriasis and atopic dermatitis Get access LENNART JUHLIN, LENNART JUHLIN CIRD, Sophia Antipolis, Valbonne, France, Department of Dermatology, University Hospital, Uppsala, Sweden Prof. Lennart Juhlin, Centre International de Kecherches ermatologiques, Sophia Antipolis, F‐06565 Valbonne, Fance. Search for other works by this author on: Oxford Academic Google Scholar SVEN HAMMARSTRÖM SVEN HAMMARSTRÖM Department of Physiological Chemistry, Karolinska Institute, Stockholm, Sweden Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 107, Issue s23, 1 November 1982, Pages 106–110, https://doi.org/10.1111/j.1365-2133.1982.tb01041.x Published: 01 November 1982
Some Effects of Health Insurance in Canada — From Private Enterprise toward Public Accountability
Authors: C. Barber Mueller
Journal: New England Journal of Medicine (1978)

Abstract Ten years after the introduction of national medical insurance in Canada, it is possible to view the effect of a comprehensive health-insurance program on the relations among physicians, society and government. With costs of health care paid from the public rather than the private purse, provincial efforts to control the cost of hospital and physician services are increasing, and various methods for cost containment are now visible. Since the budget for these expenses is publicly debated it competes for support against other publicly funded programs. The federal/provincial insurance system is evolving as an instrument of reform in the organization of health services and has led to the introduction of legislation that is changing the health-delivery system. A gradual shift in power between various health agencies, physicians, professional organizations and government is occurring. (N Engl J Med 298:535–539, 1978)
The History of Medicine in Alabama
Authors: S. Lon Conner
Journal: JAMA (1983)

If Dr Howard L. Holley did not exist, it would have been necessary for the Medical Association of the State of Alabama to invent him. Long needed in the state was a chronicle of the turbulent 19th century, during which the state association was chartered in the same year as the American Medical Association. Still pointed to with pride is the reference by an AMA official in those days to the "incomparable Alabama system." Just as the federal government was created by the states, so was the Alabama association created by local societies, and by one in particular: Mobile. The Mobile County Society was born in the early 1840s in response to two threats, charlatans and yellow fever. It seemed an open question in those days which posed the greater peril to the populace of the port city. Such prime movers in Alabama medicine as Drs Jerome Cochran and Josiah
Drug Imprinting
Authors: William O. Robertson
Journal: JAMA (1985)

PRIOR TO 1967, no reliable method short of chemical analysis existed to permit rapid, accurate identification of unknown tablets and capsules. Then, Eli Lilly and Co, Indianapolis, introduced an imprint system (Identicode) that used a three-digit alphanumeric code plus its logotype to perform such identification. Field testing confirmed that a better than 98% accuracy was achieved in less than 12 seconds.<sup>1</sup> In the succeeding decade many other pharmaceutical manufacturers adopted the technique; by 1978 more than 90% of the manufacturers illustrating tablets and capsules in the<i>Physicians' Desk Reference</i>were imprinting their products.<sup>2</sup>Nevertheless, some manufacturers declined to adopt the technology, limiting its potential effectiveness in assisting poison centers in identifying tablets or capsules in cases of accidental or purposeful overdoses, in enabling pharmacists to implement effective quality-control programs, and in helping physicians to identify new patients' prior drugs or weekend visitors' expiring prescriptions or to verify nursing
Otitis Media and Fever-Reply
Authors: Richard H. Schwartz
Journal: JAMA (1982)

In Reply.—  The statement by Drs Wright and Olson that most of our cases [of acute otitis media] were seen by numerous different pediatric residents, among whom there may not be uniform subjective criteria for making the  is the crux of the problem. We agree that such a diagnosis may not be based on uniform subjective criteria. This very fact may be reflected in the ultimate outcome—a higher frequency of fever and otitis media in the Kansas City study. However, in our study, in a private practice setting, all the children were examined by the same pediatrician. Meticulous removal of all gross cerumen and the use of brilliant halogen illumination was the rule; an otoscope head with a rubber gasket on the lens cap ensured a perfect airtight seal.  Table 3 of our article shows that of 290 patients who had acute otitis media, a myringotomy, and a culture,
Antagonists of the Mannose Receptor and the LDL Receptor–Related Protein Dramatically Delay the Clearance of Tissue Plasminogen Activator
Authors: Erik A.L. Biessen, Marco van Teijlingen, Helene Vietsch, Marrie M. Barrett-Bergshoeff, Martin K. Bijsterbosch, Dingeman C. Rijken, Theo J.C. van Berkel, Johan Kuiper
Journal: Circulation (1997)

Background Clinical application of tissue plasminogen activator (TPA) as a fibrinolytic agent is complicated by its rapid clearance from the bloodstream, which is caused by TPA liver uptake. The mannose receptor on endothelial liver cells and the LDL receptor–related protein (LRP) on parenchymal liver cells were reported to contribute to liver uptake. Methods and Results In this study, we addressed whether TPA clearance can be delayed by inhibiting receptor-mediated endocytosis of TPA. A series of cluster mannosides was synthesized, and their affinity for the mannose receptor was determined. A cluster mannoside carrying six mannose groups (M 6 L 5 ) displayed a subnanomolar affinity for the mannose receptor ( K i =0.41±0.09 nmol/L). Preinjection of M 6 L 5 (1.2 mg/kg) reduced the clearance of 125 I-TPA in rats by 60% because of specific inhibition of the endothelial cell uptake. The low toxicity of M 6 L 5 , combined with its accessible synthesis and high specificity for the mannose receptor, makes it a promising agent to improve the pharmacokinetics of TPA. Blockade of LRP by 39-kD receptor-associated protein (GST-RAP) also inhibited TPA clearance by 60%. Finally, combined preinjection of M 6 L 5 and GST-RAP almost completely abolished reduced liver uptake of TPA and delayed its clearance by a factor of 10. Conclusions It can be concluded that (1) the mannose receptor and LRP appear to be the sole major receptors responsible for TPA clearance and (2) therapeutic levels of TPA can be maintained for a prolonged time span by coadministration of the aforementioned receptor antagonists.
Surgical treatment of 125 patients with non-small cell lung cancer and chest wall involvement.
Authors: C. C. Pitz, A. Brutel de la Riviere, H. R. Elbers, C. J. Westermann, J. M. van den Bosch
Journal: Thorax (1996)

BACKGROUND: The optimum operative procedure for lung cancer with chest wall invasion (T3) remains controversial. In this study results of en bloc resection and extrapleural dissection are reviewed to determine survival characteristics. METHODS: Between 1977 and 1993 125 patients underwent surgery for primary non-small cell lung cancer with chest wall invasion. Patients with superior sulcus tumours, metastatic carcinomas, synchronous tumours, or recurrences were excluded. Extrapleural dissection was performed in 73 patients and en bloc resection (range 1-4 ribs) in 52. Resection was regarded as complete in 86 and incomplete in 39 patients. Actuarial survival time was estimated and risk factors for late death were identified. RESULTS: Hospital mortality was 3.2%. (n = 4). Estimated mean five year survival was 24% for all hospital survivors (n = 121), 11% for patients with incomplete resection, and 29% for patients having a complete resection. In patients who underwent complete resection mediastinal lymph node involvement and intrapleural tumour spill worsened the prognosis. Patients with adenocarcinoma had a better chance of long term survival. No relationship was found between survival and age, type of operative procedure, depth of chest wall invasion, and postoperative radiotherapy. CONCLUSIONS: Both operative procedures show reasonable survival results. Incomplete resection, mediastinal lymph node involvement, and intrapleural tumour spill adversely influence survival.
Under-reporting and Poor Adherence to Monitoring Guidelines for Severe Cases of Isoniazid Hepatotoxicity
Authors: Paul H. Hayashi, Robert J. Fontana, Naga P. Chalasani, Andrew A. Stolz, Jay A. Talwalkar, Victor J. Navarro, William M. Lee, Timothy J. Davern, David E. Kleiner, Jiezhun Gu, Jay H. Hoofnagle, Naga Chalasani, Raj Vuppalanchi, Jean Molleston, Lawrence Lumeng, Audrey Corne, Angie Plummer, Herbert Bonkovsky, Petr Protiva, James Freston, Robert Rosson, Robert A. Levine, Benedict Maliakkal, Paul Appleton, Mariola Smialek, Robert J. Fontana, Hari Conjeevaram, Rich Moseley, Stuart Gordon, Suzanne Welch, Jessica Worley, Jordan Kridler, Sonal Trivedi, Sweta Kochlar, Paul Watkins, Paul H. Hayashi, Mark Russo, Harry Guess, Kimberly Beaver, Alastair Smith, James Lewis, Susan Pusek, Tracy Russell, Lorraine Mehltretter, Tim Davern, Maurizo Bonacini, Kristine Partovi, Katharine Fajardo, Seaton Tai, William M. Lee, Don Rockey, Anne Larson, Lafaine Grant, Kenni Landgraf, Andrew Stoltz, Neil Kaplowitz, Susan Milstein, Jayant Talwalker, Stephanie Johnson, Victor Navarro, Rajender Reddy, Maricruz Vega, Amina Wirjosemito, Kristina Evans, James Rochon, John McHutchison, Hans Tilllmann, Mary Maggio, Hongqiu Yang, Kathy Galan, Elaina Cosslin, Lesley Sunas, Morgan Collini, Tanya Rose, Michelle Crowder, Carmel Scharenbroich, Hoss Rostami, Sherry Jiezhun, Tarka Monroe, Alex Hammett, Nidia Rosado, Jose Serrano, Leonard Seeff, Jay Hoofnagle, David Toke, Dana Witt, Heather Higgins, David Kleiner, Mark Avigan, John Senior
Journal: Clinical Gastroenterology and Hepatology (2015)
Deficiency of Suppressor T Cells in the Hyperimmunoglobulin E Syndrome
Authors: Raif S. Geha, Ellis Reinherz, Donald Leung, Kelly T. McKee, Stuart Schlossman, Fred S. Rosen
Journal: Journal of Clinical Investigation (1981)

The status of suppressor T cells (Ts) was assessed in seven children with the hyper IgE syndrome (recurrent staphylococcal infections, eczematous skin rash, and elevated serum IgE) to determine whether a deficiency in Ts is associated with increased IgE synthesis. When circulating T cells and their subsets were enumerated with the aid of monoclonal antibodies that identify T cells (T3), helper/inducer T cells (T4), and suppressor/cytotoxic T cells (T8), there was a selective deficiency of T3+ cells (51.7±11.2% vs. 66±5% for normal controls) and of T8+ cells (7.5±4.4% vs. 22±4% for normal controls) but not of T4+ cells (36.5±7.5% vs. 37±3% for normal controls).
Space Physiology and Medicine
Authors: Dana B. Mirkin
Journal: JAMA (1994)

Progressing through the final decade, one pauses to reflect upon the many accomplishments of the 20th century, not the least of which is human spaceflight. In less than 100 years powered flight has been achieved and has rapidly advanced to sustained travel and exploration in outer space. The rich scientific discoveries associated with spaceflight have enhanced our understanding of human physiology in extreme environments and will, no doubt, influence the practice of medicine by those who participate in this great adventure. The hazards are many and include radiation, microgravity, motion sickness, depressurization, launch and reentry forces, meteoroids, orbital debris, changes in circadian rhythm, extreme temperature changes, isolation, cramped quarters, the potential for systems failure, and so on. Imagine, if you will, the practice of medicine in a hostile environment in which common everyday functions such as eating, exercise, work, hygiene, sleep, and even breathing present challenges to be overcome yet
Bipolar Brain Chemistry
Authors: Rebecca Voelker
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Initial Management of Glycemia in Type 2 Diabetes Mellitus
Authors: David M. Nathan
Journal: New England Journal of Medicine (2002)

An asymptomatic 45-year-old Hispanic man has a fasting plasma glucose level of 142 mg per deciliter (7.9 mmol per liter) on initial evaluation and 139 mg per deciliter (7.7 mmol per liter) on reevaluation. Other than a steady gain in weight since college and borderline hypertension, his medical history is unremarkable. He is 175 cm (5 ft 9 in.) tall and weighs 95 kg (209 lb; body-mass index, 31.2), and his blood pressure is 138/88 mm Hg. Physical examination is notable only for abdominal obesity and absent ankle reflexes. How should this patient be treated?
Extending Brady Background Checks Opposed
Authors: Thomas Cole
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal