tbuckley/cabot-search huggingface dataset:
Abstract A51: p53 and p21 mRNA and protein expression in treated synthetic estrogen in mouse transgenic animal model
Authors: Mohd Nazil Salleh, Tan Mei Cheng, Thuaibah Hashim, Henkie Isahwan Ahamd Mulyadi Lai, Wan Khairuzzaman Wan Ramli
Journal: Cancer Research (2013)

Abstract Studies with Diethylstilbestrol (DES) in humans and rodents have resulted in a spectrum of toxic and carcinogenic effects. Previous findings on gene expression profiles following DES treatment showed that p53, p21 and bax was transcriptionally regulated in this model. In the present studies,Reverse Transcriptase in situ Polymerase Chain Reaction and immunohistochemistry techniques for localization and expression of p53, p21 and bax at cellular levels was applied. Animal were housed individually and treated with 500μmole/kg b.w of DES, (ip) once daily up to 4 days. Our results have shown, the expression of p53, p21 and bax mRNA were greater in wild-type compared to p53+/- knockout mice. In addition, p53, p21 and bax mRNA were significantly higher in DES-treated compared to control-vehicle animals. Collectively, similar patterns of expression also were seen in p53 and p21 proteins and scored according to the percentage of positive nuclear staining. Therefore, the combination of p53 and p21 were concluded to be a valuable markers and prognostic for carcinogenesis and progression of endometrial cancer. Citation Format: Mohd Nazil Salleh, Tan Mei Cheng, Thuaibah Hashim, Henkie Isahwan Ahamd Mulyadi Lai, Wan Khairuzzaman Wan Ramli. p53 and p21 mRNA and protein expression in treated synthetic estrogen in mouse transgenic animal model. [abstract]. In: Proceedings of the Third AACR International Conference on Frontiers in Basic Cancer Research; Sep 18-22, 2013; National Harbor, MD. Philadelphia (PA): AACR; Cancer Res 2013;73(19 Suppl):Abstract nr A51.
11023-112 Exercise Training in Postinfarction Patients with Left Ventricular Dysfunction. Preliminary Results of the Exercise in Left Ventricular Dysfunction (ELVD) Trial
Authors: Pantaleo Giannuzzi, Pier L. Temporelli, Marinella Gattone, Ugo Corrà, Amerigo Giordano, Luigi Tavazzi
Journal: Journal of the American College of Cardiology (1995)
Perspectives in spina bifida.
Authors: B M Wright
Journal: BMJ (1979)

does not form calcium complexes in bone- forming tissue.Brucellosis, also mentioned by Brock and Roach, is fortunately uncommon within the British Isles3; but co-trimoxazole,4 either alone or in combination with streptomycin, offers highly effective chemotherapy.In this vulnerable group of patients, if a tetracycline is thought to be obligatory, doxycycline would be the least toxic of the group, as its affinity for calcium has been shown to be less than that of the other tetra- cyclines.5However, even this agent is potentially dangerous in childhood and during pregnancy, and must be avoided if at all possible.
Top-Accessed Article: Combination Gel of 1% Amitriptyline and 0.5% Ketamine to Treat Refractory Erythromelalgia Pain
Authors: Gil Yosipovitch
Journal: JAMA Dermatology (2013)

Sandroni P, Davis MP. Combination gel of 1% amitriptyline and 0.5% ketamine to treatrefractoryerythromelalgiapain:anewtreatmentoption?ArchDermatol.2006; 142(3):283-286. Erythromelalgia is a rare skin disorder characterized by severe burning pain, warmth, and erythema that is aggravated by heat and exercise. It is considered to be a neurovascular disorder associated with a small nerve fiber neuropathy and alteredvoltage-gatedsodiumchannels.Inrecentyears,neuromodulatingagents,such as gabapentin and pregabalin, as well as topical lidocaine, were found to be useful therapies. However, there are cases of erythomelalgia that remain resistant to these conventionaltherapiesandcauseextremesuffering.SandroniandDavisreportusing a novel treatment featuring combination gel of 1% amitryptiline hydrochloride and 0.5% ketamine hydrochloride in lecithin pluronic organogel applied 4 to 5 times a day in 5 patients with intractable erythromelalgia. In 4 of these patients, a significant response was noted, with the improvement rate ranging from 50% to 95%. The rationale for this combination can be explained by specific pathways that aretargeted.KetamineisanN-methyl-Daspartate(NMDA)receptorantagonistand a modulator of glutamatergic receptors. This is important since NMDA and glutamate are known to play a key role in neuropathic pain. Amitriptyline is a tricyclic antidepressant, which helps reduces pain in various disorders owing to its ability to block voltage-gated sodium ion channels. While topical application in limited body areas in this study did not lead to systemic absorption, the safety profile of thispreparationhasnotbeenfullyassessed.Nonetheless,thisanecdotalreportholds
Abstract LB-234: A comparative genomic approach for identifying synthetic lethal interactions in human cancer.
Authors: Michael K. Asiedu, Raamesh Deshpande, Mitchell Klebig, Shari Sutor, Elena Kuzmin, Jeff Piotrowski, Seung Ho Shin, Michael Costanzo, Charles Boone, Dennis A. Wigle, Chad L Myers
Journal: Cancer Research (2013)

Abstract Synthetic lethal interactions enable a novel approach for discovering specific genetic vulnerabilities in cancer cells that can be exploited for the development of therapeutics. This concept has recently been exploited in the development of PARP inhibitors as novel chemotherapeutics for breast cancer. While PARP is not essential in normal cells, BRCA mutant cells are dependent on it for their survival. This led to the successful treatment of BRCA mutant tumors of the breast, ovary, and prostate with the oral PARP inhibitor, olaparib. Therapeutic strategies based on such synthetic-lethal (SL) interactions can enable drug targeting of cancer-specific alterations for otherwise undruggable tumor suppressors. Large-scale analyses of genetic interaction networks in model organisms like yeast suggest that disease-specific networks should not only give rise to destructive phenotypes (e.g. uncontrolled cell growth), but will also present unique vulnerabilities that can be exploited for novel therapies. Despite successes in model organisms such as yeast, discovering synthetic lethal interactions on a large scale in human cells remains a significant challenge. We have used a combination of computational and experimental approach whereby yeast interactions between human orthologs are filtered by cancer association and prioritized by genomic features, and candidates from the prioritized list are then validated in human cell lines using an RNA interference approach. As a proof of principle, we utilized this approach to discover two previously unknown synthetic lethal/sick interactions, one between SMARCB1 (yeast SNF5) and PSMA4 (yeast PRE9), and another between ASPSCR1 (yeast UBX4) and PSMC2 (yeast RPT1) based on shRNA double knock-down in normal human fibroblast cells. These interactions suggest potentially new therapeutic targets for SMARCB1 and ASPSCR1 mutated cancers, and more broadly, illustrate the potential of this cross-species approach. Citation Format: Michael K. Asiedu, Raamesh Deshpande, Mitchell Klebig, Shari Sutor, Elena Kuzmin, Jeff Piotrowski, Seung Ho Shin, Michael Costanzo, Charles Boone, Dennis A. Wigle, Chad L Myers. A comparative genomic approach for identifying synthetic lethal interactions in human cancer. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr LB-234. doi:10.1158/1538-7445.AM2013-LB-234
Back Pain: The History and Physical Examination-Reply
Authors: Richard A. Deyo
Journal: JAMA (1993)

In Reply.  —I thank Drs Abromovitz, Frazier, Kelleher, Rothschild, and Weintraub for their interest and comments. Their letters offer an opportunity to reemphasize several points, and my colleagues and I invite them all to join us in seeking better evidence regarding the accuracy and usefulness of the history and physical examination. There are several parallel but different ways to think about test accuracy, and different ones are being adopted by different generations of clinicians. None is inherently better than any other and some of the writers call attention to the advantages and disadvantages of various statistics. These points are discussed in greater detail by Sackett in his introductory article to the series on the rational clinical examination. 1   We are unaware of data on the reproducibility or validity of the tests proposed by Dr Abromovitz. Some recent studies challenge the role of facet joints as a common cause of back
The Comparative Cost-effectiveness of Statistical Decision Rules and Experienced Physicians in Pharyngitis Management
Authors: Randall D. Cebul
Journal: JAMA (1986)

We examined whether probability-based decisions for streptococcal pharyngitis, using probabilities derived from predictive models along with Tompkins' decision rules, could be more cost-effective than the actual decisions of ten physicians. We retrospectively calculated the probability of a positive throat culture ("disease") for each of 310 patients using four different models based on discriminant analysis (1), a branching algorithm (2), and logistic regression (3 and 4). "Projected decisions" were based on these probabilities and Tompkins' rules. We calculated direct medical and indirect costs per correct action taken (diseased patient-treated or nondiseased patient-not treated). Two models' projected decisions were more cost-effective than the physicians'. Model 1 primarily would have reduced treatment costs (leaving no diseased patient untreated); model 4 primarily would have reduced throat culture costs (with 15% projected undertreatment). While using statistical decision rules may be cost-effective in this setting, their adoption should be consistent with physician and patient priorities. (<i>JAMA</i>1986;256:3353-3357)
Review and Notes: Medical Software: Reference Manager: Bibliography Management SoftwareVersion 6.01. Carlsbad, CA
Authors: Daniel Mimouni
Journal: Annals of Internal Medicine (1996)

Literature of Medicine1 January 1996Review and Notes: Medical Software: Reference Manager: Bibliography Management SoftwareVersion 6.01. Carlsbad, CAResearch Information Systems; 1994. Single-user price, $349.00; optional capture module $149.00. Order phone 619-438-5526. Requires Microsoft Windows 3.1 and 2MB RAM. Also available for Macintosh (version 2.08), which requires System 4.2 or higher and 1MB RAMDaniel Mimouni, MD and Eytan Z. Blumenthal, MDDaniel Mimouni, MDBeilinson Medical Center, Petah-Tiqva, 49100 IsraelHadassah University Hospital Jerusalem, 91120 IsraelSearch for more papers by this author and Eytan Z. Blumenthal, MDBeilinson Medical Center, Petah-Tiqva, 49100 IsraelHadassah University Hospital Jerusalem, 91120 IsraelSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-124-1_Part_1-199601010-00038 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Bibliographic software packages perform two important tasks that are indispensable for researchers and clinicians. First, they create, store, and maintain bibliographic databases consisting of references that can be typed in or downloaded from a commercial vendor of bibliographic data (such as Grateful Med, Paper-Chase, or a CD-ROM-based MEDLINE system). Second, they generate a perfectly punctuated and styled citation list, ready to be attached to a manuscript or grant proposal, that can be formatted to the precise specifications of any given journal.Among the numerous packages on the market, Reference Manager is an excellent choice because of its well-designed, clear interface ... Author, Article, and Disclosure InformationAuthors: Daniel Mimouni, MD; Eytan Z. Blumenthal, MDAffiliations: Beilinson Medical Center, Petah-Tiqva, 49100 IsraelHadassah University Hospital Jerusalem, 91120 Israel PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1996Volume 124, Issue 1_Part_1 Page: 79-80 Keywords Computer software Computers Databases Information technology Internet ePublished: 15 August 2000 Issue Published: 1 January 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
The influence of mesenteric denervation on the inhibition of gastric secretion by fat in the intestine
Authors: J. Isaza, K. Sugawara, J. Curt, E. R. Woodward
Journal: Gut (1971)

The inhibitory effect of fat in the upper small intestine was studied in dogs prepared with a Heidenhain pouch, gastric fistula, and jejunal fistula. Gastric secretion was stimulated by a constant intravenous infusion of pentagastrin, and emulsified olive oil was introduced into the jejunum. The small intestine of the dog was denervated by complete transection of the mesentery except for the superior mesenteric vessels. After intestinal denervation inhibition of the vagally innervated stomach was almost abolished while that in the Heidenhain pouch was unchanged. It is concluded that either autonomic innervation is important in the formation of enterogastrone or, more likely, that efferent inhibitory fibres in the vagus to the stomach act synergistically with enterogastrone.
Rescuing age-related memory loss
Authors: Monica Hoyos Flight
Journal: Nature Reviews Drug Discovery (2011)

Forgetfulness, distractibility and impaired executive function are manifestations of the normal ageing process in both humans and monkeys, and can be observed as early as in middle age.This decline in working memory is associated with prefrontal cortex (PFC) dysfunction, but the underlying molecular basis was unknown until now.Arnsten and colleagues, reporting in Nature, show from in vivo recordings that PFC neurons in aged monkeys have weaker connections and fire less robustly than in younger animals.Furthermore, this condition can be rescued by modulating the neurochemical environment.
Stapes Surgery for Otosclerosis
Authors: G. Kelemen
Journal: JAMA (1962)

Stapedial and peristapedial surgery, practiced on a fairly large scale around the turn of the century, was dormant until about 10 years ago, when, revived, it reached an unprecedented degree of prestige. From the beginning of this renaissance the author was one of the protagonists, not merely performing the surgical intervention, but also working out the difficult question of indications and thoroughly evaulating the results. Hence, he was most competent to give a survey of the status of the problems which stand in the foreground of interest. After discussing the pathology of stapes ankylosis, the physiologic considerations regarding the basis of the hearing loss are analyzed. Differential diagnosis, indications for surgery, surgical techniques, evaluation of results, and semicircularcanal fenestration are dealt with in separate chapters. Some 29 detailed case histories accompany the abundantly illustrated work, leaving little doubt, that albeit many surgical and other problems remain to be solved, long-lasting
Phase II study of pegylated liposomal doxorubicin (PLD) and carboplatin (Cb) can be administered with trastuzumab (H) in patients with metastatic breast cancer.
Authors: RP Collea, FW Kruter, JE Cantrell, TK George, S Kruger, AM Favret, DL Lindquist, AM Melnyk Jr., RE Pluenneke, SH Shao, MW Crockett, L Asmar, JA O'Shaughnessy
Journal: Cancer Research (2009)

Abstract Abstract #6118 Background: PLD and Cb are active in metastatic breast cancer (MBC) but no data exist regarding the antitumor activity of the combination. Both agents are synergistic with H in preclinical studies. The primary objective of this study was to determine the objective response rates (ORR) produced by PLD+Cb ± H.&amp;#x2028; Patients and Methods: 133 patients (pts) were registered to the study; 125 pts were treated and were stratified by HER2 status; 124 pts are currently evaluable for response. Pts had measurable disease per RECIST criteria and had received no more than 1 prior chemotherapy regimen for MBC; HER2+ pts received therapy first-line therapy for metastatic and 4% received prior adjuvant H. All pts received PLD 30 mg/m2 IV followed by Cb, AUC=5 IV on Day 1 of 28-day cycles. In addition to PLD+Cb, HER2+ pts received H on Day 1 and Day 15 (8 mg/kg IV first dose; 4 mg/kg IV subsequent doses).&amp;#x2028; Results: 79 pts and 46 pts received at least 1 dose of study drug on PLD+Cb (Arm 1) and PLD+Cb+H (Arm 2), respectively. Median age was 56 years. Estrogen receptor (ER) or progesterone receptor (PR) + pts and ER and PR- pts in Arm 1/Arm 2 were 63%/55% and 36%/45%, respectively, 49%/43%; pts were treated with prior doxorubicin in Arm 1/Arm 2 and 51%/30%. With prior taxane in Arm 1/Arm 2, of 79 pts on Arm 1 evaluable for response, 27% had an objective response compared with 53% of the 45 pts currently evaluable on Arm 2. Median overall survival was 17 months in Arm 1 and as not been reached in Arm 2. Median PFS is 5 and 10 months for Arm 1 and 2, respectively. The most common Grade 3-4 treatment-related toxicities for Arm 1/Arm 2 were: neutropenia 23%/35%, leukopenia 13%/22%, thrombocytopenia 20%/17%, fatigue 6%/13%, and anemia 11%/9%.&amp;#x2028; Conclusion: PLD+Cb in combination have moderate activity in MBC; also, the addition of H to PLD+Cb in HER2+ pts enhanced its activity. Preliminary toxicity results suggest that PLD can be safely combined with H with minimal cardiac toxicity. Final data analyses from this fully enrolled study will be reported at SABCS 2008.&amp;#x2028; This research was supported, in part, by a research grant from Ortho Biotech Clinical Affairs, LLC, Bridgewater, NJ. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 6118.
Lipoid pneumonia: an occupational hazard of fire eaters.
Authors: B Beermann, T Christensson, P Moller, A Stillstrom
Journal: BMJ (1984)

started.The chest pain was very intense and was relieved first after inter- costal blockade and high doses of dextropropoxyphene and paracetamol.The patient's condition deteriorated during the next week with fever up to 39-4°C.Analysis of blood gases showed a fall of oxygen pressure P02 to 8-4 kPa (63 mm Hg), and the pulmonary infiltrates increased in size and pleural effusion appeared (fig 2).Erythrocyte sedimentation rate increased to 131 FIG 1-Chest x ray film immediately after inhalation of liquid paraffins.
Oral, nonabsorbable antibiotics prevent infection in cirrhotics with gastrointestinal hemorrhage
Authors: Antoni Rimola, Felipe Bory, Josep Teres, Rosa M. Perez-Ayuso, Vicente Arroyo, Joan Rodes
Journal: Hepatology (1985)

To investigate if oral, nonabsorbable antibiotics prevent bacterial infections in cirrhotics with gastrointestinal hemorrhage, 140 consecutive patients were randomly allocated into two groups: 68 patients (Group I) were given oral, non absorbable antibiotics (gentamicin + vancomycin + nystatin or neomycin + colistin + nystatin) from the inclusion into the trial up to 48 hr after cessation of the hemorrhage, or until emergency surgery or death in those cases who continued bleeding; and 72 patients (Group II) did not receive oral, nonabsorbable antibiotics. Both groups were similar in relation to clinical and laboratory data and characteristics of the hemorrhage. The incidence of infection was significantly lower in Group I than in Group II (11 patients in Group I and 25 in Group II developed proved infections; p less than 0.025). This difference was due to the fact that spontaneous bacteremia and peritonitis and urinary tract infection caused by enteric bacteria occurred almost exclusively in Group II. Two patients of Group I and 10 of Group II developed spontaneous bacteremia and/or peritonitis caused by enteric bacteria (p less than 0.025). These results indicate that prophylactic administration of oral, nonabsorbable antibiotics markedly reduces the incidence of infections caused by enteric bacteria in cirrhotic patients with gastrointestinal hemorrhage.
Turning tumor inhibition into activation: engineering T cells with chimeric signaling receptors
Authors: Ramona Schlenker, Matthias Leisegang, Wolfgang Uckert, Elfriede Noessner
Journal: Journal for ImmunoTherapy of Cancer (2014)

Meeting abstracts Poor in vivo persistence and loss of function of adoptively transferred T cells in the tumor milieu are known shortcomings of adoptive T cell therapy (ATT). Providing costimulation might help to improve ATT efficiency. However, human CD8 T effector cells are largely CD28 negative
Influence of Surface‐Imprinted Nanoparticles on Trypsin Activity
Authors: António Guerreiro, Alessandro Poma, Kal Karim, Ewa Moczko, Jessica Takarada, Isabel Perez de Vargas‐Sansalvador, Nicholas Turner, Elena Piletska, Cristiana Schmidt de Magalhães, Natalia Glazova, Anastasia Serkova, Aleksandra Omelianova, Sergey Piletsky
Journal: Advanced Healthcare Materials (2014)

Here, the modulation of enzyme activity is presented by protein-imprinted nanoparticles produced using a solid-phase approach. Using trypsin as target, binding of the nanoparticles to the enzyme results in its inhibition or in stabilization, depending on the orientation of the immobilized enzyme used during imprinting.
Variation in response to cytotoxicity of cigarette smoke.
Authors: J M Hopkin, V S Tomlinson, R M Jenkins
Journal: BMJ (1981)

The cytotoxic effect of cigarette smoke condensate on human polymorphs was investigated in vitro by the method of vital dye exclusion. Exposure to 1/800 of the smoke from one high-tar cigarette killed a detectable proportion of a population of 10(6) cells. The response among the cells from 40 healthy people varied widely, the percentage of dead cells ranging from 3% to 66% and from 17% to 87% at exposure levels of 125 micrograms and 250 micrograms cigarette smoke condensate respectively. Differences in individuals' responses were reproducible and unrelated to age or sex or smoking habit. The cells from 10 patients with irreversible obstructive airways disease and probable emphysema were significantly more sensitive than those from 10 patients with no respiratory disability matched for age and smoking habits. Genetically influenced variation in cellular response to cytotoxicity may be an important determinant of the risk of developing emphysema among smokers.
Isolated Pancreas Transplantation for Type 1 Diabetes
Authors: David M. Nathan
Journal: JAMA (2003)

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