General Side Effects
Authors: JOHN P. UTZ
Journal: Annals of Internal Medicine (1964)

Clinical Staff Conference1 August 1964General Side EffectsJOHN P. UTZ, M.D.JOHN P. UTZ, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-2-340 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe undesirable effects of the administration of the commercially available, colloidal (solubilized) form of amphotericin B may be divided into the idiosyncratic reactions, that is, those that occur in an isolated patient after usually only a small dose of drug, and the side effects that occur in almost every patient and are generally dose related. The idiosyncratic reactions include anaphylactoid shock, thrombocytopenia, acute liver failure, flushing, vertigo, generalized pain, grand mal convulsions, cardiac arrest, and ventricular fibrillation.The side effects of intravenous administration include phlebitis, fever, chills, nausea, vomiting, headache, anorexia, hypokalemia, abnormal renal function, and anemia. The latter three...References1. SEABURYDASCOMB JHHE: Experience with amphotericin B. Ann. NY Acad. Sci. 89: 202, 1960. CrossrefMedlineGoogle Scholar2. TYNESUTZBennettALLING BJJPJEDW: Reducing amphotericin B reactions: a double blind study. Amer. Rev. Resp. Dis. 87: 264, 1963. MedlineGoogle Scholar3. UTZANDRIOLE JPVT: Analysis of amphotericin B treatment failures in systemic fungal disease. Ann. NY Acad. Sci. 89: 277, 1960. CrossrefMedlineGoogle Scholar4. WILSON JW: Therapy of systemic fungous infections in 1961. Arch. Intern. Med. (Chicago) 108: 292, 1961. CrossrefMedlineGoogle Scholar5. WINN WA: Coccidioidomycosis and amphotericin B. Med. Clin. N. Amer. 47: 1131, 1963. CrossrefMedlineGoogle Scholar6. SPICKARDBUTLERANDRIOLEUTZ AWTVTJP: The improved prognosis of cryptococcal meningitis with amphotericin B therapy. Ann. Intern. Med. 58: 66, 1963. LinkGoogle Scholar7. ANDRIOLEKRAVETZ VTHM: The use of amphotericin B in man. JAMA 180: 269, 1962. CrossrefMedlineGoogle Scholar8. OPPELTRALL WWDP: Production of convulsions in the dog with intrathecal corticosteroids. Neurology 11: 925, 1961. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Bethesda, Maryland PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByPancreas preservation with amphotericin B deteriorates islet yield for porcine islet isolationAntifungal macrocycle antibiotic amphotericin B — its present and future. Multidisciplinary perspective for the use in the medical practiceFDA Approved Drug Library Screening Identifies Robenidine as a Repositionable AntifungalComparative evaluation of amphotericin B binding to the native and modified forms of rice lipid-transfer protein: a possible perspective on improving the drug-binding affinity and specificityNonclinical Toxicological Evaluation of Occidiofungin, a Unique Glycolipopeptide AntifungalHIV-associated cryptococcal meningitisA single high dose treatment of kala-azar with Ambisome (amphotericin B lipid complex): a pilot studyAmBisome®: Long Circulating Liposomal Formulation of Amphotericin BSupramolecular lipidic drug delivery systems: From laboratory to clinic A review of the recently introduced commercial liposomal and lipid-based formulations of amphotericin BTwo-hour versus six-hour administration of amphotericin B in the treatment of kala-azarRapid infusion of amphotericin B, revisitedAmphotericin B and its delivery by liposomal and lipid formulationsThe effect of thromboxane A2 receptor antagonism on amphotericin B-induced renal vasoconstriction in the ratDevelopment, Characterization, Efficacy and Mode of Action of Ambisome, A Unilamellar Liposomal Formulation of Amphotericin BComparison of nephrotoxicities of different polyoxyethyleneglycol formulations of amphotericin B in ratsToxicities of Antimicrobial Agents Used to Treat OsteomyelitisAdministration of Antiinfectives in Minimum Volume and Infusion TimesToxicity of amphotericins on chronic administration to mongrel dogsRenal magnesium wasting associated with amphotericin B therapyDelirium and depression associated with amphotericin BIn Vitro and In Vivo Studies of Ambruticin (W7783): New Class of Antifungal AntibioticsTherapeutic Properties of Oral Ambruticin (W7783) in Experimental Pulmonary Coccidioidomycosis of MiceAdministration of Amphotericin BRenal Ultrastructure After Amphotericin BChemistry and biology of the polyene macrolide antibioticsNephrotoxicity of amphotericin B, with emphasis on changes in tubular function 1 August 1964Volume 61, Issue 2Page: 340-343KeywordsConvulsionsDrug administrationFeversHeadachesHeartNauseaShockVentricular fibrillationVertigoVomiting Issue Published: 1 August 1964 PDF DownloadLoading ...