tbuckley/cabot-search huggingface dataset:
Oral budesonide in the treatment of patients with primary biliary cirrhosis with a suboptimal response to ursodeoxycholic acid
Authors: Paul Angulo, Roberta A. Jorgensen, Jill C. Keach, Rolland E. Dickson, Coleman Smith, Keith D. Lindor
Journal: Hepatology (2000)

Ursodeoxycholic acid (UDCA) is a safe and effective medical therapy for most patients with primary biliary cirrhosis (PBC). However, some patients show an incomplete response to UDCA therapy. Treatment with corticosteroids may be of benefit although at the expense of systemic side effects. Budesonide, a corticosteroid with an extensive first-pass hepatic metabolism appeared promising for the treatment of PBC. The aim of this study was to evaluate the safety and estimate the efficacy of budesonide in patients with PBC, who have shown a suboptimal response to UDCA. Twenty-two patients with PBC, 16 women, median age of 50 who had been on UDCA (13-15 mg/kg/d) for a mean of 46 months (range 6-108 months) and had shown a persistent elevation of alkaline phosphatase activity at least 2 times the upper limit of normal were enrolled. Oral budesonide, 9 mg daily was administered for 1 year and patients continued on the same dosage of UDCA. There was a significant, but transitory improvement in serum levels of total bilirubin (P = .001) and a significant, but marginal improvement in serum alkaline phsophatase (P = .001) with combination therapy. The Mayo risk score increased significantly (P = .02) and there was a significant loss of bone mass (P < .001) of the lumbar spine. Budesonide-induced hyperglycemia and cosmetic adverse effects were noted in 2 patients. In conclusion, oral budesonide appears to add minimal, if any, additional benefit to UDCA, and it is associated with a significant worsening of osteoporosis in patients with PBC.
OLM interneurons differentially modulate CA3 and entorhinal inputs to hippocampal CA1 neurons
Authors: Richardson N Leão, Sanja Mikulovic, Katarina E Leão, Hermany Munguba, Henrik Gezelius, Anders Enjin, Kalicharan Patra, Anders Eriksson, Leslie M Loew, Adriano B L Tort, Klas Kullander
Journal: Nature Neuroscience (2012)
The normal range in diagnostic phototesting
Authors: B.L. DIFFEY, P.M. FARR
Journal: British Journal of Dermatology (1989)

Journal Article The normal range in diagnostic phototesting Get access B.L. DIFFEY, B.L. DIFFEY Regional Medical Physics Department, Dryburn Hospital, Durham, U.K. Dr B.L.Diffey, Regional Medical Physics Department, Dryburn Hospital, Durham DH1 5TW, U.K. Search for other works by this author on: Oxford Academic Google Scholar P.M. FARR P.M. FARR Department of Dermatology Royal Victoria Infirmary, Newcastle upon Tyne, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 120, Issue 4, 1 April 1989, Pages 517–524, https://doi.org/10.1111/j.1365-2133.1989.tb01325.x Published: 01 April 1989
Death rates fell significantly after Massachusetts implemented 2006 health reform
Authors: M. McCarthy
Journal: BMJ (2014)

Death from all causes in non-elderly residents of Massachusetts—those age 20 to 64—fell by 2.9% in the four years after it implemented its 2006 health reform law, and deaths from causes amenable to healthcare interventions fell by 4.5%, a new study says.1

The Massachusetts law served as a model for the national US health reform law, the Affordable Care Act—which, like the Massachusetts law, sought to increase health insurance coverage by expanding eligibility for Medicaid, creating a health insurance exchange where people could purchase subsidized private coverage, and establishing an individual mandate that required everyone to obtain health insurance …
Care of the dying in general practice.
Authors: I G Finlay
Journal: BMJ (1985)

The hospice movement has improved the care for the dying patient. But can the hospice experience be easily applied to general practice? In one year in this practice 10 patients were terminally ill, and three of these died at home. The clinical problems encountered over four years are described to illustrate the factors that affect prescribing, which makes caring for a dying patient at home different from that in hospital or even in a hospice.
Adenomyosis as Seen on Blood Flow and Blood Pool Imaging During Bone Scintigraphy
Authors: ALBERT J. MORENO, ELMER J. PACHECO, ALAN L CARPENTER, ANA A. RODRIGUEZ, GOTTLIEB L. TURNBULL
Journal: Clinical Nuclear Medicine (1994)

A 42-year-old woman presented with intermittent low back and left lower extremity pain. The blood flow and blood pool images of bone scintigraphy showed a large focus of increased activity in the right lower abdomen. Computed tomography showed an enlarged uterus displaced to the right side of the pelvis. At surgery, the uterus was found to be involved with adenomyosis. Three-phase bone scintigraphy consisting of blood flow and blood pool images over the anterior pelvis may be a valuable diagnostic aid in the evaluation of lower back or pelvic pain of a woman.
Diuretic Abuse and Central Pontine Myelinolysis
Authors: Paul M. Copeland
Journal: Psychotherapy and Psychosomatics (1989)

Patients with eating disorders often use diuretics to eliminate fluid to achieve lower body weight. Diuretic abuse can lead to severe hyponatremia. Central pontine myelinolysis, a disruption of the myelinated neurons of the pons, has been associated with rapid correction of severe hyponatremia. A case is presented of a 35-year-old woman who was brought to the emergency service by ambulance complaining of vomiting for 7 days and that she could not hear well because she was 'worn out'. Initial laboratory values included serum Na 91 mEq/l, K 1.6, Cl 46, bicarbonate 33, BUN 4 mg/dl, glucose 306 mg/dl. After 32 h of intravenous fluids, the serum Na was 126, K 4.0, Cl 89, bicarbonate 25, glucose 118 mg/dl. On the 3rd hospital day the serum Na was 139. On the 4th hospital day she was alert and appropriate. On the 5th hospital day, however, she was confabulating and chatty. The serum Na was 139. She progressed to develop a spastic quadriparesis, speech and swallowing difficulties. A magnetic resonance imaging scan showed central pontine myelinolysis. She acknowledged taking 400 mg daily of furosemide and drinking much water. She had a past history of anorexia nervosa. She had a residual weight phobia and strove to keep her weight below 106 lb. Her height was 5 feet, 6 inches. As illustrated by this case, diuretic abuse can cause severe hyponatremia and the subsequent risk of central pontine myelinolysis. In patients with severe chronic or subacute hyponatremia, a safe restoration rate for serum Na has been less than 0.55 mEq/l/h. Serum Na should be below 135 within the first 48 h and hypernatremia should be avoided.
Abstract 1196: FZD7 plays a critical role in triple negative breast cancer proliferation
Authors: Lixin Yang, Xiwei Wu, Xutao Deng, Sean Lau, George Somlo, Yun Yen
Journal: Cancer Research (2011)

Abstract Breast cancer is genetically and clinically heterogeneous. Triple negative cancer is a subtype of breast cancer, most of which is associated with poor outcome and the lack of benefit from target therapy. A pathway analysis in a microarray study was performed using triple negative breast tumor cells compared with non-triple negative breast tumor cells. Overexpression among several Wnt pathway genes, such as FZD7, LRP6 and TCF7 has been observed in triple negative breast tumors. To validate their function, inhibition of FZD7 using FZD7-shRNA was carried out. Noticeably decreased cell proliferation, suppressed invasiveness and colony formation in triple negative MDA-MB-231 and BT-20 cells were observed. Mechanism study indicated that these effects occurred through silencing the canonical Wnt signaling pathway, as evidenced by loss of nuclear accumulation of β-catenin and decreased transcriptional activity of TCF7. Our finding suggests that FZD7 involved canonical Wnt signaling pathway is essential for tumorigenesis of triple negative breast tumor. Thus, FZD7 may be a biomarker and a potential therapeutic target for triple negative breast cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1196. doi:10.1158/1538-7445.AM2011-1196
Alternative Splicing at NAGNAG Acceptor Sites Shares Common Properties in Land Plants and Mammals
Authors: K. Iida, M. Shionyu, Y. Suso
Journal: Molecular Biology and Evolution (2008)

In recent years, several papers have reported that a special type of alternative splicing (AS) event occurs at the tandem 3′ splice site, termed the “NAGNAG acceptor.” This type of AS event (termed AS-NAGNAG) is well studied in both human and mouse. To illustrate the significance of AS-NAGNAG events, we focused on their occurrence in Arabidopsis thaliana and Oryza sativa (rice). Our study is the first genome-wide approach examining AS-NAGNAG events in land plants. Based on transcripts and genomic sequences, we found 321 and 372 AS-NAGNAG events in Arabidopsis and rice, respectively. These events were significantly enriched in genes encoding DNA-binding proteins, and more than half of all AS-NAGNAG events affected polar amino acid residues. The observed properties of AS-NAGNAG events in plants were similar to those seen in mammals. These results showed that AS-NAGNAG events may provide a mechanism for fine-tuning of DNA-binding proteins in both mammals and land plants. We found 7 gene groups of AS-NAGNAG events that were conserved between Arabidopsis and rice, including 2 groups for RNA-binding proteins. Conservation of the events for RNA-binding proteins is a property also seen in mammals. Furthermore, we found 23 gene groups containing AS-NAGNAG events that occurred in noncorresponding introns of homologous genes. They included 5 groups of DNA-binding proteins, whose number was larger than expected. We think there is a bias with which AS-NAGNAG events are fixed in genes for DNA-binding proteins. Our analysis showed that AS-NAGNAG events found in land plants share similar properties with those in mammals. Based on our results, we propose that AS-NAGNAG events are likely to be a common mechanism in the fine-tuning of protein functions, especially DNA/RNA-binding proteins, in both mammals and plants. Their role might contribute to the construction of complicated transcriptomes and proteomes in the evolutionary history of mammals and land plants.
Volume of procedures and risk of recurrence after repair of groin hernia: national register study
Authors: Pär Nordin, Willem van der Linden
Journal: BMJ (2008)

To determine whether the association between volume and outcome found in major surgery also holds true for a minor operation.Review of outcomes after hernia surgery in Sweden.Surgical units registered with the Swedish hernia register, which in 2004 covered about 95% of all hernia operations in Sweden.86,409 patients over 15 years, who underwent 96,601 unilateral or bilateral groin hernia repairs (94,077 inguinal and 2524 femoral) in 1996-2004 at the participating surgical units.Re-operation for recurrence.There was a significantly higher rate of re-operation in surgeons who carried out 1-5 repairs a year than in surgeons who carried out more repairs. There was no association between outcome and further increases in volume. Although about half of surgeons in Sweden who repair hernias are low volume operators, they performed only 8.4% of all repairs.Sweden's numerous low volume hernia surgeons perform such a small proportion of all operations that the impact of their inferior results on the nationwide re-operation rate is minimal. Volume indicates an approximate minimum value for the number of hernia repairs a surgeon should do each year but the outcome in surgeons who carry out more than that number disqualifies volume as an indicator of proficiency.
Association of Thymic Stromal Lymphopoietin Genetic Variants in Urticaria/Angioedema Induced by Multiple Nsaids
Authors: Maria del Carmen Plaza-Serón, Pedro Ayuso Parejo, Natalia Blanca-López, Inmaculada Doña, María José Torres, Javier Fernández, Jose Julio Laguna, Veronique Goidenau, Luisa Galindo, Rocio Herrera, Gabriela Canto, Miguel Blanca, Jose Antonio Cornejo-García
Journal: Journal of Allergy and Clinical Immunology (2013)
Sunscreen adherence: proffer patient preference
Authors: F.R. Ali, A. Aslam, J.T. Lear
Journal: British Journal of Dermatology (2014)

Journal Article Sunscreen adherence: proffer patient preference Get access F.R. Ali, F.R. Ali Dermatology Centre University of Manchester Salford Royal NHS Foundation Trust Manchester Academic Health Science Centre Manchester M6 8HD U.K Search for other works by this author on: Oxford Academic Google Scholar A. Aslam, A. Aslam Dermatology Centre University of Manchester Salford Royal NHS Foundation Trust Manchester Academic Health Science Centre Manchester M6 8HD U.K Search for other works by this author on: Oxford Academic Google Scholar J.T. Lear J.T. Lear Dermatology Centre University of Manchester Salford Royal NHS Foundation Trust Manchester Academic Health Science Centre Manchester M6 8HD U.K Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 171, Issue 6, 1 December 2014, Page 1567, https://doi.org/10.1111/bjd.13136 Published: 01 December 2014
Abstract 4806: Angiogenesis is independently influenced by interstitial flow and concentration gradients of tumor secreted morphogens
Authors: Venktesh S. Shirure, Steven C. George
Journal: Cancer Research (2014)

Abstract Angiogenesis facilitates growth and entry of tumors into the systemic circulation leading to metastasis. Morphogens, such as vascular endothelial growth factor (VEGF), secreted by the tumors are believed to guide nearby vasculature towards the tumor. The distribution of morphogens in tissues is affected by interstitial fluid flow, which also exerts forces in the tissue microenvironment. Numerous cells in the tumor microenvironment can sense and respond to force, yet our understanding of the independent effect of interstitial flow in tumor angiogenesis is limited. This is due, in part, to inadequate experimental models that cannot decouple spatial morphogen concentrations and interstitial flow. Notably, control of these parameters is not possible in animal models, and 2D cell systems lack the complexity of in vivo tissue. We addressed these limitations by designing a microfluidic platform of polydimethlsiloxane (PDMS) polymer consisting of three parallel microporous tissue compartments (&amp;lt; 0.1 mm3 total volume) that are media-fed with microfluidic lines. Endothelial colony forming cell-derived endothelial cells (ECFC-EC) and stromal fibroblasts in extracellular matrix proteins (e.g., fibrin and collagen) seeded in the central compartment formed interconnected microvascular networks with hollow lumens in 7-14 days. A mathematical model of mass and momentum transport in the microfluidic device was used to determine experimental conditions that either minimize the concentration gradients or the interstitial flow across the tissue chamber. The conditions were validated experimentally using various molecular size fluorescent dextrans. In the absence of a concentration gradient, microvessels demonstrated a striking bias for angiogenesis against the direction of the interstitial flow. Furthermore, the extent of migration against the flow increased with increasing interstitial flow. In separate experiments with minimal/no interstitial flow, angiogenisis is biased towards a positive concentration gradient of the morphogens such as VEGF. In conclusion, we have developed a novel microfluidic platform that can decouple the effects of concentration gradients and interstitial flow. Using this platform we show that angiogenesis is independently influenced by interstitial flow and concentration gradients of tumor secreted morphogens. Citation Format: Venktesh S. Shirure, Steven C. George. Angiogenesis is independently influenced by interstitial flow and concentration gradients of tumor secreted morphogens. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4806. doi:10.1158/1538-7445.AM2014-4806
Checks and Balances in Peer Review: Advice from the Patrick Case
Authors: Deborah M. Prout
Journal: Annals of Internal Medicine (1988)

Editorials1 November 1988Checks and Balances in Peer Review: Advice from the Patrick CaseDeborah M. Prout, MASDeborah M. Prout, MASSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-9-689 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptToo often the concept of "checks and balances" is relegated to forgotten civics classes and to texts on government. In a society seeking news in brief, and among physicians desiring certitude in law and public policy, headlines such as that carried by the New York Times on the Patrick case seem to say it all: "Doctors Can Sue in Peer Reviews, Justices Declare" (1).But legislative determinations, and hence the law, are best understood when viewed through the prism of checks and balances.Patrick v. Burget et al. (2) is a stunning example of a case in which the nuances...References1. Doctors can sue in peer reviews, justices declare. New York Times. 17 May 1988:A1. Google Scholar2. United States Supreme Court. Timothy A. Patrick v. William M. Burget el al. No. 86-1145. Certiorari to the United States Court of Appeals for the Ninth Circuit. 16 May 1988. Google Scholar3. Dolin L. Antitrust law versus peer review. N Engl J Med. 1985;313:1156-7. CrossrefMedlineGoogle Scholar4. United States Supreme Court. Timothy A. Patrick v. William M. Burget et al. No. 86-1145. Certiorari to the United States Court of Appeals for the Ninth Circuit. 16 May 1988:4. Google Scholar5. United States Supreme Court. Timothy A. Patrick v. William M. Burget et al. No. 86-1145. Certiorari to the United States Court of Appeals for the Ninth Circuit. 16 May 1988:11. Google Scholar6. United States Supreme Court. Timothy A. Patrick v. William M. Burget et al. No. 86-1145. Certiorari to the United States Court of Appeals for the Ninth Circuit. 16 May 1988:6. Google Scholar7. Waxman H. Medical malpractice and quality of care. N Engl J Med. 1987;316:943-4. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Public Policy American College of Physicians Washington, DC Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByOh What a Tangled Web We Weave 1 November 1988Volume 109, Issue 9Page: 689-690KeywordsPeer reviewPublic policy Issue Published: 1 November 1988 PDF DownloadLoading ...
Renal Parenchymal Malakoplakia
Authors: Pravit Cadnapaphornchai, Barbara F. Rosenberg, Saadi Taher, Eric H. Prosnitz, Franklin D. McDonald
Journal: New England Journal of Medicine (1978)

MALAKOPLAKIA, described in 1902,1 is an unusual chronic inflammatory disease generally confined to the collecting system of the urinary tract. Renal parenchymal involvement is rare and was bilateral in only five2 3 4 5 6 of the 11 reported cases. Two of these patients4,5 had evidence of obstruction that could have caused the compromised renal function. The two patients with bilateral renal parenchymal malakoplakia and renal failure described below had no evidence of obstruction.Case ReportCase 1. A 35-year-old woman was admitted to Detroit General Hospital with severe bilateral low-back pain. Four days before admission she had weakness, fever, dysuria and urinary frequency. . . .
Lovastatin and Visual Changes
Authors: Lawrence E. Mieczkowski, James M. Holahan
Journal: Annals of Internal Medicine (1989)

Letters and Corrections1 March 1989Lovastatin and Visual ChangesLawrence E. Mieczkowski, MD, James M. Holahan, ODLawrence E. Mieczkowski, MDSearch for more papers by this author, James M. Holahan, ODSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-110-5-410_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: Lovastatin is an effective and well-tolerated medication for patients with hypercholesterolemia (1). A potent inhibitor of the rate-limiting enzyme 3-hydroxy-3-methylglutaryl enzyme A in cholesterol synthesis, it has not been associated with cataract formation, unlike earlier investigative drugs that blocked cholesterol synthesis (2). Although new lens opacities have developed in some patients receiving lovastatin, others "lost" opacities, and drug therapy was not discontinued in any of the patients because of ocular side effects (3). We report a case of significant visual changes that occurred in a patient soon after the institution of lovastatin therapy.A 52-year-old man had...References1. HavelHunninghakeIllingworth RDD. Lovastatin (mevinolin) in the treatment of heterozygous familial hypercholesterolemia. Ann Intern Med. 1987;107:609-15. LinkGoogle Scholar2. LaughlinCarey RT. Cataracts in patients treated with triparanol. JAMA. 1962;181:129-30. CrossrefGoogle Scholar3. HunninghakeMillerGoldberg DVI. Lovastatin: follow-up ophthalmologic data [Letter]. JAMA. 1988;259:354-5. CrossrefMedlineGoogle Scholar4. Aine E. Refractive errors in a Finnish rural population. Acta Ophthalmol. 1984;62:944-54. CrossrefGoogle Scholar5. The 1989 Physician's Desk Reference. 43rd ed. Oradell, New Jersey: Medical Economics Company, Inc.; 1988. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByLong Term Clinical Tolerance of Lovastatin (Mevinolin) and Simvastatin (Epistatin)Lovastatin and Visual ChangesFrank W. Newell, MD 1 March 1989Volume 110, Issue 5Page: 410-411KeywordsCholesterolDrug synthesisDrug therapyDrugsEnzymes Issue Published: 1 March 1989 PDF DownloadLoading ...
Fatal heat stroke in a long distance runner
Authors: M Khogali, K Gumaa, M K Y Mustafa
Journal: BMJ (1983)

muscular 29 year old man, was admitted with a high body temperature, tachycardia, and peripheral circulatory failure with a metabolic acidosis.Over the next six hours the metabolic acidosis progressed and he developed wide- spread haemorrhages in muscle and in mucous membranes and skin.On further inquiry we note he was found to have hypertonicity of muscles and hyperreflexia.Also, just before the terminal cardiac arrest he was severely acidotic with a pH of 7 08 and a base excess of -19 7. The serum lactate concentration at that time was raised at 2 9 mmol/l (26-1 mg/100 ml) (normal 1-8 mmol/l (16 2 mg/100 ml)).We believe that malignant hyperpyrexia could explain the clinical findings.This diagnosis carries an important therapeutic implication, as dantrolene has been shown to be effective in treating this condition.