tbuckley/cabot-search huggingface dataset:
Influenza Will Not Occur in 1976 if We are Determined to Prevent It
Authors: William R. Barclay
Journal: JAMA (1976)

No one can be certain that a serious influenza epidemic will or will not occur in the United States in 1976-1977. However, major influenza pandemics have occurred approximately every ten years, and the last one recorded was "Hong Kong Flu" in 1968. Therefore, there is a strong possibility of an influenza epidemic in 1976-1977. Characteristically, a minor outbreak of a virulent influenza strain occurs in a limited area several months in advance of a major epidemic from the strain. Therefore, the influenza that occurred in military personnel at Fort Dix early this year may be a harbinger of what could occur in the winter of 1976-1977. The personnel infected in the Fort Dix outbreak were seriously ill; one person died, and the virus isolated appears to be antigenically similar to the virus that swept through the world in 1918 and 1919. Although the 1918 influenza virus and the virus isolated
Characterization of in vivo somatic mutations at the hypoxanthine phosphoribosyltransferase gene of a human control population.
Authors: K Burkhart-Schultz, C B Thomas, C L Thompson, C L Strout, E Brinson, I M Jones
Journal: Environmental Health Perspectives (1993)

The ability to recognize a change in mutation spectrum after an exposure to a toxic substance and then relate that exposure to health risk depends on the knowledge of mutations that occur in the absence of exposure. Toward this end, we have been studying both the frequency and molecular nature of mutations of the hypoxanthine phosphoribosyltransferase (hprt) gene in peripheral blood lymphocytes as surrogate reporters of genetic damage. We have analyzed mutants, one per donor to ensure independence, from a control population in which the quantitative effects of smoking and age on mutant frequency have been well defined. Analyses of cDNA and genomic DNA by polymerase chain reaction and sequencing have identified the mutations in 63 mutants, 45 from males and 18 from females, of which 34 were smokers and 29 were nonsmokers. Slightly less than half of the mutations were base substitutions; they were predominantly at GC base pairs. Different mutations at the same site indicated that there are features of the hprt polypeptide that affect the mutation spectrum. Two pairs of identical mutations indicated that there may also be hot spots. Mutations not previously reported have been detected, indicating that the mutation spectrum is only partly defined. The remainder of the mutations were deletions or insertions/duplications; deletions ranged from one base pair to complete loss of the locus. Despite a small average increase in mutant frequency for smokers, an increased proportion of base substitutions at AT base pairs in smokers (p = 0.2) hinted at a smoking-associated shift in the mutation spectrum.(ABSTRACT TRUNCATED AT 250 WORDS)
Half of poor people in UK are in a working family, report says
Authors: J. Wise
Journal: BMJ (2014)

Half of all people in poverty in the United Kingdom are in a family with someone in paid work, says the annual report written by the New Policy Institute for the social policy research charity the Joseph Rowntree Foundation.1

The report says that the UK labour market has changed significantly in the past 10 years, with a big increase in insecure work such as jobs on zero hours contracts, part time work, and low paid self employment. Getting a job does not necessarily mean getting out of poverty, the report says.

The UK today has 13 million people in …
Growth Hormone–Releasing Hormone Improves Cognitive Function in Older Adults: Sleep On It
Authors: Christian Benedict, Colin D. Chapman, Helgi B. Schiöth
Journal: JAMA Neurology (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Deaths after peritoneal lavage with mercuric chloride solutions: case report and review of the literature.
Authors: T Laundy, A E Adam, J B Kershaw, D J Rainford
Journal: BMJ (1984)

Une observation: lavage peritoneal au moyen d'une solution de chlorure mercurique au cours d'une operation pour epithelioma glandulaire kystique de l'ovaire; la malade meurt le 6eme jour d'intoxication mercurielle (ascite, insuffisnance renale, epanchements pleuraux, œdeme pulmonaire, colite avec ulcerations)
Letter: Suppository inserter: new aid for the disabled.
Authors: A T Day
Journal: BMJ (1973)

necrotic that cortical damage becomes notable.Sometimes part or all of the necrotic papillae are cast off, but in other cases they remain in situ.In this event, cortical damage is more severe.Indeed, we have noted that when the papilla is shed leaving a sharp line of demarcation, as in the combination of infection and diabetes or of analgesic damage and infection, cortical damage may be remarkably slight.The determinant of cortical damage appears to us to be the degree of obstruction imposed by a necrotic papilla remaining in situ or by sclerosis at the line of separation.Perhaps it is a matter of semantics, but
Evaluation of mechanical prototype machines for continuous separation of respirable cotton dust fractions.
Authors: L B DeLuca
Journal: Environmental Health Perspectives (1986)

The original cotton particulates analyzer used stationary screens to separate aerodynamically the coarse and fine dust fractions from small samples of cotton. By replacing stationary with rotary screens that were continuously cleaned, larger supplies of respirable dust were obtained without interruption. A ginned and a waste cotton were used to test two methods of separation: a rotating 38-micron screen and a tandem rotating 710- or 38- micron screen and cyclone. The fine dust fractions from both systems were captured on filters and examined gravimetrically, by Coulter counter, and scanning electron microscope. The dust passing 38 micron stationary or rotary screens contained particles of 15 micron maximum diameter whereas dust from the 710-gmm rotary screen and tandem cyclone exhibited particles of 10 micron maximum diameter and lint fragments. Dust fractions with particles less than 10 micron diameter and free of lint were obtained with a 38-micron rotary screen and tandem cyclone.
Chemokines and Pro-Inflammatory Cytokines in Down’s Syndrome: An Early Marker for Alzheimer-Type Dementia?
Authors: Mauro G. Carta, Paolo Serra, Assunta Ghiani, Elisabetta Manca, Maria Carolina Hardoy, Gennaro S. Del Giacco, Giacomo Diaz, Bernardo Carpiniello, Paolo E. Manconi
Journal: Psychotherapy and Psychosomatics (2002)

People with Down's syndrome (DS) show early Alzheimer-like dementia. It has been suggested that the pro-inflammatory cytokine class plays a role in Alzheimer's disease (AD). The study aims at verifying whether pro-inflammatory cytokines in DS are correlated with age, affective symptoms and intellectual decline to a different degree than in subjects with non-DS learning disabilities.19 subjects with DS; controls: sex- and age-matched individuals with learning disabilities caused by perinatal ischaemic damage. The level of mental retardation was assessed according to DSM-IV; psychopathological symptoms were measured by the Assessment and Information Rating Profile. Serum levels of cytokines were determined with ELISA.DS patients showed higher levels of cytokines and chemokines, with the exception of RANTES; but the only significant difference detected was for MIP-1alpha. A correlation between the degree of mental retardation and IL-6, and between MIP-lalpha and age was found in patients with DS, but not in controls.The data obtained suggest a possible involvement of chemokines in the inflammatory and degenerative processes similar to AD in DS. Further longitudinal research is required to confirm these findings.
Inquiry into lung transplant fiasco in Quebec
Authors: D. Spurgeon
Journal: BMJ (1997)

The Quebec College of Physicians has been placed by the province's health minister, Jean Rochon, in the unenviable position of explaining a mess the minister himself created.

Some months ago Mr Rochon ordered all lung transplant operations to be transferred from Montreal, where they had been carried out successfully for years, to Sainte-Foy, a suburb of Quebec City (1 February, p 325). His decision, unpopular with patients and surgeons alike, was …
Primary Familial Bilateral Carpal Tunnel Syndrome
Authors: ROBERT G. GRAY
Journal: Annals of Internal Medicine (1979)

We identified bilateral carpal tunnel syndrome in 19 of 43 living persons of a nonconsanguineous family. No single common etiologic feature was seen. Sixty-three percent of the afflicted kindred had symptomatic digital flexor tenosynovitis. Noninflammatory thickening of the flexor retinaculum or tendon sheaths, or both, was the commonest surgical finding. The 44% prevalence, early age of onset, and equal sex ratio differ from idiopathic carpal tunnel syndrome. Family pedigree suggests an inheritable disorder transmitted by an autosomal dominant gene with a high degree of penetrance.
Doctors vote for English health bill to be withdrawn
Authors: Jacqui Wise
Journal: BMJ (2011)

Doctors attending the BMA’s special representative meeting today in London voted overwhelmingly for the withdrawal of the Health and Social Care Bill, saying that the current plans for reform are too extreme and too rushed and will have a negative effect on the care of patients. Representatives also backed a motion calling on the BMA to lobby against the introduction of legislation that obliges commissioners to always seek “any willing provider” and calling for the NHS to be the preferred provider wherever NHS provision is accepted to be of good quality. The meeting also called on the health secretary to:
Vascular dysfunction after repair of coarctation of the aorta
Authors: Marcello de Divitiis, Carlo Pilla, Mia Kattenhorn, Mariutzka Zadinello, Ann Donald, Paul Leeson, Sharon Wallace, Andrew Redington, John E. Deanfield
Journal: Circulation (2001)

Patients with repaired coarctation are at increased risk of hypertension and cardiovascular disease despite successful repair. We studied the function of conduit arteries in upper and lower limbs of patients late after successful coarctation repair and its relation to age at surgery.Flow-mediated dilatation (FMD) and the dilatation after sublingual nitroglycerin (NTG, 25 microgram) were measured by using high-resolution ultrasound in the brachial artery in 64 coarctation patients (44 males and 20 females, aged 19+/-10 years; median age at operation 4 months) and 45 control subjects (28 males and 17 females, aged 19+/-10 years) and in the posterior tibial artery in 37 patients and 22 control subjects. Arterial stiffness was determined by pulse-wave velocity (PWV) of the brachioradial and femoral-dorsalis pedis tracts. Patients, compared with control subjects, had lower brachial FMD (7.16+/-3.4% versus 8.62+/-2.3%, respectively; P=0.02) and NTG (11.46+/-4.3% versus 13.21+/-4.6%, respectively; P=0.046) and higher brachioradial PWV (9.17+/-3.1 versus 8.06+/-1.9 m/s, respectively; P=0.05). In contrast, posterior tibial FMD, NTG, and lower limb PWV were comparable. Age (months) at the time of repair was related to brachioradial PWV (r=0.42, P=0.002) but not to brachial FMD or NTG.Patients with repaired aortic coarctation have impaired conduit artery function, with abnormal responses to flow and NTG, and increased vascular stiffness confined to the upper part of the body. Early repair is associated with preserved elastic properties of conduit arteries, but reduced reactivity remains.
THE PATHOLOGY OF SYPHILIS IN A NEW LIGHT.*
Authors: JOHAN ALMKVIST
Journal: British Journal of Dermatology (1937)

Journal Article THE PATHOLOGY OF SYPHILIS IN A NEW LIGHT. Get access JOHAN ALMKVIST, M.D. JOHAN ALMKVIST, M.D. Stockholm Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 49, Issue 1, 1 January 1937, Pages 1–12, https://doi.org/10.1111/j.1365-2133.1937.tb11143.x Published: 01 January 1937
Persistent diffuse pulmonary interstitial emphysema mimicking pulmonary emphysema
Authors: Y Demura, T Ishizaki, M Nakanishi, S Ameshima, H Itoh
Journal: Thorax (2007)

A 69-year-old male non-smoker with a history of atopic asthma of >30 years had recently been diagnosed with pulmonary emphysema (chronic obstructive pulmonary disease, COPD) because of exertional dyspnoea and chronic airflow limitation without bronchodilator responsiveness. A laboratory examination revealed a high serum IgE level (1219 U/ml) and a normal α1-antitrypsin level (142 mg/dl), and the flow-volume curve showed severe chronic airflow obstruction (vital capacity (VC) 2.47 litres (72.3% predicted), forced expiratory volume …
Inducibility of the 70 kD Heat Shock Protein in Peripheral Blood Monocytes Is Decreased in Human Acute Respiratory Distress Syndrome and Recovers Over Time
Authors: PHILIPPE DURAND, MARIA BACHELET, FABRICE BRUNET, MARIE JEANNE RICHARD, JEAN-FRANÇOIS DHAINAUT, JOSETTE DALL'AVA, BARBARA S. POLLA
Journal: American Journal of Respiratory and Critical Care Medicine (2000)

The heat shock/stress proteins (HSP), and, in particular, the inducible, cytosolic Hsp70, represent an extremely conserved response to many different cellular injuries, including reactive oxygen species (ROS). Hsp70 has been shown to confer to cells and tissues protection against the deleterious effects of ROS or cytokines, both in vitro and in animal models of acute respiratory distress syndrome (ARDS). We hypothesized that Hsp70 expression levels in peripheral blood monocytes (PBM) of patients with ARDS, would correlate with disease severity. We prospectively included 13 patients with previous ARDS (50 +/- 17 yr; range, 20 to 76 yr), nine ventilated patients with non-ARDS/ALI disease (45 +/- 20 yr; range, 19 to 76 yr), and 14 healthy volunteers (45 +/- 20 yr; range, 22 to 77 yr). PBM activation state was evaluated according to their membrane expression of CD16, and oxidative status according to plasma lipid peroxidation products. Both baseline expression and Hsp70 inducibility (after in vitro heat shock) were examined in PBM, using flow cytometric analysis. We found that basal expression of Hsp70 in PBM was similar for patients and control subjects, whereas Hsp70 inducibility- a reflection of the ability to mount a stress response-was significantly reduced in the patients with ARDS (p = 0. 02). Among all correlation analyses we considered between Hsp70 inducibility on the one hand, clinical and laboratory biomarkers for disease severity and outcome in the patients with ARDS on the other, only the duration of ventilatory support was significant (p < 0.003). As an approach to distinguish between disease and ventilation, we also analyzed a group of, ventilated patients without ARDS. Our results indicate that in patients with ARDS, Hsp70 inducibility in PBM is decreased, but it recovers over time with duration of ventilatory support.
Morphology of vulnerable coronary plaque: insights from follow-up of patients examined by intravascular ultrasound before an acute coronary syndrome
Authors: Masakazu Yamagishi, Mitsuyasu Terashima, Kojiro Awano, Mikihiro Kijima, Satoshi Nakatani, Satoshi Daikoku, Kenichi Ito, Yoshio Yasumura, Kunio Miyatake
Journal: Journal of the American College of Cardiology (2000)
Comparison of Injection Sclerotherapy and Laser Photocoagulation for Bleeding Peptic Ulcers
Authors: R. Pulanić, B. Vucelić, M. Rosandić, M. Opacić, N. Rustemović, Ž. Krznarić, T. Brkić, N. Jokić-Begić
Journal: Endoscopy (1995)

The most widely used endoscopic procedures in the management of patients with bleeding peptic ulcer are at present sclerotherapy and thermal methods. In an attempt to assess the most effective method of achieving hemostasis, we compared injection sclerotherapy and laser photocoagulation in terms of the efficacy of initial hemostasis, rebleeding, need for surgery, mortality, and the appearance of the ulcer after the hemostatic procedure.In this prospective, randomized trial, 160 patients were treated with injection sclerotherapy (1% polidocanol), and 155 patients with laser photocoagulation (Nd:YAG laser) in cases of Forrest I, Forrest IIa, and Forrest IIb hemorrhage. The bleeding activity was classified according to the modified Forrest criteria. Polidocanol injection and Nd:YAG laser photocoagulation were not preceded by epinephrine administration.There were no significant overall differences between the groups in the outcome in terms of definitive hemostasis, rebleeding, urgent surgery, and death (p = 0.487). In the case of the subgroup with Forrest I lesions, laser photocoagulation was more efficacious than sclerotherapy (p = 0.0078). In the Forrest IIa and Forrest IIb subgroups, the two methods were equally effective (p = 0.202 and 0.513 respectively). In the sclerotherapy patients, definitive initial hemostasis in Forrest IIa was achieved in 100%, whereas in the laser group this rate was 92%, with 28% of patients initially developing hemorrhage after one or two laser pulses. Ulcer healing was slower following sclerotherapy than after photocoagulation.Injection sclerotherapy and laser photocoagulation are equally effective in achieving definitive hemostasis in bleeding peptic ulcers. Laser photocoagulation is more efficacious in patients with active bleeding, whereas injection sclerotherapy is more effective in patients with a nonbleeding visible vessel.
Failure Patterns Relative to Radiation Treatment Fields for Stage II–IV Thymoma
Authors: Andreas Rimner, Daniel R. Gomez, Abraham J. Wu, Weiji Shi, Ellen D. Yorke, Andre L. Moreira, David Rice, Ritsuko Komaki, Kenneth E. Rosenzweig, Gregory J. Riely, James Huang
Journal: Journal of Thoracic Oncology (2014)
Substance Abuse and Violent Crime in Patients With Schizophrenia—Reply
Authors: Seena Fazel
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The World Medical Association.
Authors: H Hillman
Journal: BMJ (1979)

When he finished reading the paper he tore it into small pieces and started throwing the pieces out of the window.The second man said, "What are you doing that for ?" and the first man answered, "I do it to keep down the elephants."Whereupon the second man said, "There aren't any elephants" and the first replied, "Effective, isn't it ?"
Pancreatitis after renal transplantation.
Authors: P Corrodi, M Knoblauch, U Binswanger, E Scholzel, F Largiader
Journal: Gut (1975)

Pancreatitis is seldom seen as a severe complication of renal transplantation. In a review on 1321 renal transplants, 23 cases with 12 deaths are reported (Johnson and Nabseth, 1970). Single case reports may be added. In our departments pancreatitis has proved to be a fairly frequent complication. It developed in 10 (7 percent) of 147 patients with renal transplantation one week to seven and a half years after transplantation (patients with primary hyperparathyroidism excluded). Three of the eight acute cases had haemorrhagic pancreatitis, in two of them leading to death. Two patients had chronic calcifying pancreatitis. Pancreatitis was complicated in one case by abscess formation and in two by severe haemorrhage into a pseudo-cyst. In two patients the diagnosis was made at necropsy only and death was probably not related to the acute pancreatitis. The exact pathogenesis of pancreatitis after renal transplantation cannot be precisely assessed. Possible contributing factors are treatment with corticosteroids, azathioprin, and L-asparaginase, early hypercalcaemia after transplantation, surgery, infections of bacterial or viral origin, and unknown immunological processes.
Eberth's Typhoid Bacillus
Authors: J. Coats
Journal: BMJ (1882)

since the introduction of artificial digestives.Pepsine, in its various forms, and hydrochloric acid, were long used in stomach digestion, before their value was recognised in rectal alimentation.Pepsine is now very much replaced by the preparations of pancreatine, the latter possessing the double power of acting on proteids as well as on starch.
THE SPECIFICITY OF KERATEINE DERIVATIVES
Authors: L. Pillemer, E. E. Ecker, E. W. Martiensen
Journal: The Journal of Experimental Medicine (1939)

Carboxymethyl, alpha-carboxyethyl-, alpha-carboxy-n-propyl-, alpha-carboxyisopropyl-, alpha-carboxy-n-butyl, alpha-carboxyisobutyl, alpha-carboxyamyl-, benzyl-, and beta-phenylethylkeratemes were prepared from the parent protein, reduced keratin or kerateine. Chemical analysis disclosed that the various compounds differed in their isoelectric points and solubilities depending on the nature of the substituent group introduced. In general, it was found that in so far as could be determined, nearly all of the available sulfhydryl groups were substituted, while no detectable substitution of the free amino groups of the proteins occurred. The results of the serologic studies revealed that the kerateine derivatives acquired a new immunologie character dependent on the nature of the introduced determinant group. Inhibition tests confirmed the results obtained. Evidence was also produced to show that the grouping See PDF for structure may play a rôle in some of the reactions observed.