tbuckley/cabot-search huggingface dataset:
An Outpatient Data System
Authors: Paul Y. Ertel
Journal: JAMA (1970)

A computer based outpatient data system, which is used in a major pediatric teaching hospital, was designed to simplify record keeping in a large decentralized clinic operation and to conserve professional time. Family and case demographic information and clinical data are collected as critical bits (selected and unduplicated input). Data acquisition forms serve as integrated components of the patient's record and as vehicles to enhance patient flow. Error surveillance programs, external reports, and internal reports for administrative purposes are generated at nominal cost. In a period of 21 months, the processing of more than 187,000 forms demonstrates the efficacy of the system.
The Effect of Independent Practice Association Plans on Use of Pediatric Ambulatory Medical Care in One Group Practice
Authors: Peter G. Szilagyi
Journal: JAMA (1990)

We compared the use of pediatric ambulatory medical care of 640 children who switched from a traditional Blue Cross plan to more comprehensive independent practice association plans with that of matched patients who remained with Blue Cross in one large, suburban pediatric practice in Rochester, NY. A quasi-experimental, retrospective cohort design was used. Use of pediatric ambulatory medical care by patients in the independent practice association plan and control patients was determined by medical chart review for 1 year before and 1 year after each patient's switch. During the baseline year, patients who would join the independent practice association plan already had 19% more acute-illness visits than control patients. During the second year, patients in the independent practice association plan averaged 42% more acute-illness visits, 22% more well child-care visits, 93% more chronic-illness visits, 27% more after-hours visits, 53% more weekend visits, 185% more laboratory studies, and 70% more referrals. The shift toward independent practice association plans in this open-market setting increased use of ambulatory medical care for pediatric patients.
Suitability of common drugs for patients who avoid animal products
Authors: K. C. Tatham, K. P. Patel
Journal: BMJ (2014)

Many patients avoid eating animal products for various reasons, but how many doctors consider this when prescribing a drug? Even if they do, <b>Kate Tatham</b> and <b>Kinesh Patel</b> find it is hard to determine whether drugs meet the patient's dietary requirements
BACILLI OF THE HOG-CHOLERA GROUP (BACILLUS CHOLERÆ SUIS) IN MAN
Authors: Carl Tenbroeck
Journal: The Journal of Experimental Medicine (1920)

1. The organisms isolated by Hirschfeld from febrile cases resembling paratyphoid fever and named Paratyphoid C can be placed in the hog-cholera bacillus group by their agglutination absorption properties though they are not typical culturally. 2. When fed to a pig a febrile disease resulted from which the animal recovered. After injection of hog-cholera virus the organisms fed were found generally, distributed and some of them had lost cultural characters so that they are brought into the class of typical hog-cholera bacilli except for their low virulence for rabbits. 3. While hog-cholera bacilli have many opportunities to infect man. they either are not able to grow in the human body or, what is less likely, they do grow and lose the characters that distinguish them.
RISK OF HEART FAILURE HOSPITALIZATION OR DEATH FOLLOWING NON-CARDIOVASCULAR HOSPITALIZATION IN PATIENTS WITH MILDLY SYMPTOMATIC HEART FAILURE TREATED WITH CARDIAC RESYNCHRONIZATION THERAPY
Authors: Eric D. Hansen, Valentina Kutyifa, Arthur Moss, Scott McNitt, Ilan Goldenberg, Wojciech Zareba
Journal: Journal of the American College of Cardiology (2013)
Ampullary metastasis from breast cancer: an unusual finding
Authors: R. Rego, M. Atiq, N. Velchala, D. Nevin, D. McElreath, W. McKnight, F. Aduli
Journal: Endoscopy (2009)

A third of women with breast cancer will develop metastatic disease [1]. However, gastrointestinal involvement with metastatic breast cancer is rare and may pose a diagnostic challenge [2] [3] [4]. We present two cases of metastatic breast cancer with unusual gastrointestinal findings.
Influence of training on myocardial responses of rats subjected to conditions of ischaemia and hypoxia
Authors: R. A. CAREY, C. M. TIPTON, D. R. LUND
Journal: Cardiovascular Research (1976)

Physical training has been advocated to minimize the problems associated with coronary heart disease; however, the responsible mechanisms are obscure. Rats trained to run on a treadmill were subjected to acute conditions of hypoxia and myocardial ischaemia. Trained rats were better able to maintain a higher level of cardiac performance (dP/dtmax) after hypoxia than non-trained rats, but no advantages were apparent after ischaemia. Biochemical data showed no myocardial differences between the groups in oxygen utilization or energy availability.
A neurobiological approach to imitation
Authors: Jean Decety, Julie Grèzes
Journal: Behavioral and Brain Sciences (1998)

To explore the neural mechanisms engaged by the perception of action with the intent to imitate, positron emission tomographic activation studies were performed in healthy human subjects. We discuss the results in light of the framework proposed by Byrne &amp; Russon, especially the distinction between mechanisms subserving action-level and program-level imitation.
Misuse of Drugs Regulations 1973.
Authors: D A Cahal
Journal: BMJ (1974)

The Misuse of Drugs Regulations 19731 were made in accor dance with the powers granted to the Home Secretary by the Misuse of Drugs Act 1971. The regulations, together with the Misuse of Drugs (Notification of and Supply to Addicts) Regulations 1973,2 came into operation on 1 July 1973. On the same date regulations 1, 2, 5, and schedule 1 of the Misuse of Drugs (Safe Custody) Regulations 19733 came into operation; the remainder will become operative on 1 October 1974.
Long-term synaptic depression in the mammalian brain
Authors: David J. Linden
Journal: Neuron (1994)

A generally accepted hypothesis in neurobiology has been that at the cellular level, memories are stored, at least in part, as long-term alterations in the strength of synaptic tranmission. In recent years, considerable attention has been paid to persistent, use-dependent mechanisms that increase synaptic strength, which are collectively referred to as long-term potentiation (LTP). This review shall examine the opposite phenomenon, use-dependent decreases in synaptic strength, or long-term depression (LTD). LTD is a broad term that is used to describe synaptic depression according to several different learning rules and in a wide variety of brain structures.
A NEEDLE-HOLDER FOR SUBMUCOUS RESECTION OF THE SEPTUM
Authors: Henry B. Hitz
Journal: JAMA (1913)

The principal feature of this holder is its ability to grasp securely a small curved needle, so that a suture may be passed in any direction, leaving a clear view of the operative field. The needle can be instantly released and as readily picked up again and firmly held, which is a distinct advantage over the Yankauer type. It is made after the straight punch-forceps model, the needle being grasped by the movable end in a diagonal plane. The principal advantage of this needle-holder in submucous work is the rapidity with which suturing can be done in any direction with the least possible traumatism to the frequently thin, fragile, mucoperichondrial flap. A new needle-holder for submucous resection of the septum. <h3>The Physician as a Community Asset.</h3> —A well-trained sensible doctor is one of the most valuable assets of a community, worth to-day, as in Homer's time, many another man. To
Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers
Authors: Sam Thiagalingam, Christoph Lengauer, Frederick S. Leach, Mieke Schutte, Stephan A. Hahn, Joan Overhauser, James K.V. Willson, Sanford Markowitz, Stanley R. Hamilton, Scott E. Kern, Kenneth W. Kinzler, Bert Vogelstein
Journal: Nature Genetics (1996)
273Cell to cell communication: miRNA involvement
Authors: M Climent Salarich, G Condorelli, L Elia
Journal: Cardiovascular Research (2014)

Background: Cardiometabolic diseases (CMD) are the primary cause of death and disability in the Western world. The recent developments in genetics and genomics provide a background for further investigating this area with the aim of deepening our understanding of the atherosclerotic phenomena underlying CMD. MicroRNAs (miRs) are short, non-coding RNAs that negatively regulate gene expression, and are involved in cardiovascular diseases. The cross talk between the different cell types of the vessel wall is fundamental in order to maintain the vessel integrity. This phenomenon is dysregulated during atherosclerosis development, inducing a modulation of smooth muscle cells (SMCs) and endothelial cells (ECs) biology. Methods/Results: The aim of this study is to understand whether the SMC-specific miR-143 and -145 might be transferred to ECs, then modulating their biological activity. Indeed, our data revealed that vascular stress is associated with down-regulation of miR-143 and -145 in SMCs: their modulation is responsible for SMC phenotypic switch from a contractile/non proliferative to a migratory/proliferative state. We observed that ECs, which do not normally express miR-143 and -145, do so after being co-cultured with SMCs, indicating that these miRs can be transferred from SMCs to ECs. ECs fed with SMC-conditioned media did not express miR-143 and -145. Instead, direct contact between the two cells types triggered the transfer of the miRs. This indicated that the transfer is not guided by any paracrine mechanism. Then, we observed that the transfer is restricted only to the mature miR sequences as no primary-miR-143/145 could be detected in ECs after co-culture. Conclusion: Our data suggest that dysregulation of miR-143 and -145 genes is causally involved in aberrant SMC plasticity and probably in endothelial pathophysiology encountered during vascular disease.
Asthma and obesity in children: current evidence and potential systems biology approaches
Authors: U. Frey, P. Latzin, J. Usemann, J. Maccora, U. Zumsteg, S. Kriemler
Journal: Allergy (2014)

Both obesity and asthma are highly prevalent, complex diseases modified by multiple factors. Genetic, developmental, lung mechanical, immunological and behavioural factors have all been suggested as playing a causal role between the two entities; however, their complex mechanistic interactions are still poorly understood and evidence of causality in children remains scant. Equally lacking is evidence of effective treatment strategies, despite the fact that imbalances at vulnerable phases in childhood can impact long-term health. This review is targeted at both clinicians frequently faced with the dilemma of how to investigate and treat the obese asthmatic child and researchers interested in the topic. Highlighting the breadth of the spectrum of factors involved, this review collates evidence regarding the investigation and treatment of asthma in obese children, particularly in comparison with current approaches in 'difficult-to-treat' childhood asthma. Finally, the authors propose hypotheses for future research from a systems-based perspective.
Big pharma and big medicine in big trouble
Authors: D. Spence
Journal: BMJ (2013)

Peter Gotzsche, chief of the Nordic Cochrane Center in Copenhagen, is a tough guy, happy to push over the apple cart of perceived wisdom right in front of the vendors, wearing an expression that seems to cry out, “Come and get me if you think you’re hard enough.” Like a Nordic police investigator, in his new book Deadly Medicines and Organised Crime: How Big Pharma Has Corrupted Healthcare he systematically sets out the case against the drug industry.⇑

It’s a classic courtroom drama, with lies and corruption on a truly …
Inhibition of TGF-alpha gene expression by vitamin A in airway epithelium.
Authors: L A Miller, Y H Zhao, R Wu
Journal: Journal of Clinical Investigation (1996)

The autocrine/paracrine growth mechanism has been implicated in the regulation of bronchial epithelial cell proliferation. By inhibiting the expression of the transforming growth factor-alpha (TGF-alpha) gene product, vitamin A is able to suppress the proliferation of tracheobronchial epithelial cells in culture. Similar repressions in TGF-alpha mRNA levels by retinol were observed in airway explant cultures and in a cell line immortalized from normal human bronchial epithelial cells. Both the nuclear run-on transcriptional assay and the transfection study with the chimeric construct of the TGF-alpha promoter and chloramphenicol acetyltransferase reporter gene partly suggest a transcriptional downregulation mechanism of TGF-alpha gene expression by the retinol treatment; however, this inhibition at the transcriptional level cannot account for the total inhibition at the mRNA level. These results suggest that a downregulation of the expression of the TGF-alpha gene at the transcriptional and post-transcriptional levels by vitamin A may precede the essential event associated with the homeostasis of normal conducting airway epithelium.
Endosonographic Diagnosis of Intraluminal Diverticulum
Authors: F. Maluf-Filho, F. P. Lopasso, S. E. Matuguma, R. S. Azzam, P. Sakai, S. Ishioka, T. Tomishigue
Journal: Endoscopy (1998)

After a long symptom period of 19 years a submucosal tumor was suspected on endoscopy to account for the patient's intermittent nausea and abdominal pain. Duodenal waterfilling during endoscopic ultrasound led to the endosonographic diagnosis of an intraluminal duodenal diverticulum which was removed surgically. The patient became completely asymptomatic.
Cerebral and meningeal multiple myeloma after autologous stem cell transplantation. A case report and review of the literature
Authors: S�ren L. Petersen, Aase Wagner, Peter Gimsing
Journal: American Journal of Hematology (1999)

Meningeal involvement of multiple myeloma is a very rare complication. Defining meningeal myelomatosis (MeM) as the presence of plasma cells in the cerebrospinal fluid in a patient with multiple myeloma, we have found 53 previously reported cases in the literature, where the diagnosis MeM has been made while the patient was alive. Using Kaplan Meier statistics we have found the median survival, from the time of diagnosis of MeM, to be 1.5 months. We report a case with MeM and possible cerebral myeloma shortly after autologous stem cell transplantation, and compare it with earlier published cases. Am. J. Hematol. 62:228–233, 1999. © 1999 Wiley-Liss, Inc.
Treatment of Hypercalcemia With Etidronate Disodium
Authors: J. I. Zweig, N. Shafer
Journal: JAMA (1980)

<h3>To the Editor.—</h3> Hypercalcemia can occur as an accompaniment of malignant tumors with extensive bone metastasis. The increased serum calcium results probably from bone destruction and calcium reabsorption in the metastatic sites. Etidronate disodium has the property of complexing with the calcium within the bone and partially displacing the phosphate. Phosphonate bonding decreases the rate of calcium dissolution from the bone.<sup>1-3</sup> Based on these considerations, a patient with breast cancer who hadwidespread extensive bone metastasis, intractable excruciating bone pain, and hypercalcemia, and who was no longer responsive to any form of therapy, started receiving etidronate disodium, 600 mg daily, as a last resort after the pain could no longer be controlled with analgesic medication. While the patient was receiving this drug, the serum calcium value promptly returned to normal levels (Table). It is evident that a temporal relationship exists between institution of therapy with etidronate and the serum
Rosette Inhibition Test in Severely Burned Patients
Authors: H. M. Chapel, J. R. Batchelor
Journal: BMJ (1973)

The rosette inhibition test has been advocated as a test of immune reactivity in patients given transplants. We have done the test in lymphocytes from patients with severe burns, non-burnt control patients, and normal subjects. There was no correlation with the period of immunosuppression which follows a severe burn, though both groups of patients showed a wider range of minimal inhibitory concentrations (M.I.C.) than the normal group. Wide day-to-day variation of M.I.C. in burn and control patients was noted; this seemed to correlate with the ratio of sodium to potassium excreted in the urine. In-vitro experiments suggest that the M.I.C. is correlated with a plasma constituent which may be similar in action to hydrocortisone and that the rosette inhibition test is not a direct measure of immune reactivity.
When Do Genetic Researchers Have a Duty to Recontact Study Participants?
Authors: Christopher H. Wade, Andrea L. Kalfoglou
Journal: The American Journal of Bioethics (2006)

Click to increase image sizeClick to decrease image size ACKNOWLEDGMENTS The authors would like to thank Kim Kaphingst, Vivian Ota Wang, and Colleen McBride for their constructive criticism of this manuscript. 1. The opinions expressed in this article are those of the authors and do not reflect the opinions or policies of the National Human Genome Research Institute, the National Institutes of Health, or the Department of Health and Human Services.
The Medical-Psychiatric Unit: A Novel Psychosomatic Approach
Authors: Giovanni A. Fava, Thomas N. Wise, George Molnar, Maria Zielezny
Journal: Psychotherapy and Psychosomatics (1985)

A retrospective chart review of 600 general hospital patients, of whom 200 had been admitted to a medical-psychiatric unit, 200 to a conventional psychiatric unit and 200 to medical-surgical units, and for whom psychiatric consultation had been requested, disclosed significant differences in the patient populations of these services. The data suggest that consultation psychiatry and medical-psychiatric units serve two different subgroups of patients with combined physical and psychiatric illness. A comprehensive model of clinical psychosomatic medicine encompassing consultation psychiatry, liaison psychiatry, medical-psychiatric units and after-care medical-psychiatric clinics, is proposed.
Israel adopts tough laws on rabies
Authors: J. Siegel-Itzkovich
Journal: BMJ (1998)

Israel will soon become the first country in the world to require all pet dogs and cats to have an identifying microchip inserted under their skin and to be vaccinated against rabies.

The new rules, approved by the economics committee of the Knesset, was welcomed by veterinarians but disappointed animal welfare groups. Professor Shimshony, chief veterinarian at the Agriculture Ministry, said that the new rules will save many people from having to be …
Tick-borne Relapsing Fever
Authors: R. C. Wood, K. C. Dixon
Journal: BMJ (1945)

An outbreak of epidemic diarrhoea and vomiting of unknown origin is described.Epidemiological data and previous published work suggest that the infection is due to a virus.We cannot recall a similar epidemic in this area during the past 17 years.We believe the outbreak has been widespread over the country.A field inquiry to determine its extent would be of interest.We wish to thank all the general practitioners who co-operated so well in supplying much of the data for this paper, also Miss Matthews, supervisor of the maternity department, for her assistance; Dr. J. L. Burn, medical officer of health for Salford, for assistance in making inquiries from the practitioners and at the various public health departments; and Dr.
Reviews and Notes: A Measure of Malpractice: Medical Injury, Malpractice Litigation, and Patient Compensation
Authors: Vanessa Merton
Journal: Annals of Internal Medicine (1994)

Literature of Medicine1 March 1994Reviews and Notes: A Measure of Malpractice: Medical Injury, Malpractice Litigation, and Patient CompensationVanessa MertonVanessa MertonPace University School of Law, White Plains, NY 10603Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-5-199403010-00035 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail A Measure of Malpractice: Medical Injury, Malpractice Litigation, and Patient CompensationPaul C. Weiler, Howard H. Hiatt, Joseph P. Newhouse, William G. Johnson, Troyen A. Brennan, and Lucian L. Leape. 175 pages. Cambridge, Massachusetts: Harvard University Press; 1993. $29.95.Undoubtedly this decade's most important book about medical negligence, A Measure of Malpractice provides a welcome antidote to the mythology and disinformation that has permeated most policy debate on the subject. This terse report, dense in data but not in style, summarizes in surprising detail the monumental work of the Harvard Medical Practice Study—distilling into one slender book the observations and ... Author, Article, and Disclosure InformationAffiliations: Pace University School of Law, White Plains, NY 10603 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1994Volume 120, Issue 5Page: 444-445KeywordsHealth careHealth care providersHealth economicsInsuranceMorbidityMortalityPatient advocacyPopulation statisticsResearch designTwins ePublished: 15 August 2000 Issue Published: 1 March 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
The Computer-Stored Medical Record-Reply
Authors: Thomas L. Lincoln
Journal: JAMA (1989)

<h3>In Reply. —</h3> In their letter, the writers make multiple assertions ad hominem, but only limited space is available for a short rebuttal. We editorialized that the computer-stored medical record should serve the patient first and that technical design should be subservient to that goal. The task is difficult. Elsewhere<sup>1</sup>we note that "problems... arise when one attempts to integrate the rich knowledge-base and behavioral variety of health care with the logical constraints of computer-oriented information processing." Everyone has experienced computerized procedures that are dictatorial or infuriatingly awkward—mocking Wiener's ideal (and warning) that computers should promote "the human use of human beings." A timely article<sup>3</sup>subtitled "New Technologies, Obsolete Organizations" recently reviewed the relative merits of a consistent overall design vs incremental improvement via networked islands of automation, citing Federal Express as a system that needs all of its parts to offer a significant new service. These authors
GUNSHOT WOUND OF THE BOWELS.
Authors: O. S. HUTCHINS
Journal: JAMA (1905)

<h3>Patient.</h3> —June 18, 1905, a girl, 13 years of age, while carelessly handling a 22-caliber rifle, shot herself in the abdomen one and one-half inches to the right and slightly below the middle of a line drawn from the umbilicus to the os pubis. She resided at a farmhouse ten miles in the country. Patient had vomited before I reached her, four hours after the accident, and was in considerable pain with limbs drawn up. There was increased pain on slight pressure over the bowels. Considerable shock was present. <h3>Operation.</h3> —Preparation for operation was commenced immediately. Under anesthetic, median incision was made into peritoneum. Considerable free and clotted blood was found, which was scooped out. The first loop of bowel in region of entrance of bullet into peritoneum was grasped, pulled out, and six openings in the small bowel were found in searching nearly its whole length. The openings were
Robert Cox Zeta Marion Ursula Eastes Henry Colin Geldard Grace Edith Harland (nee Mellows) John Charles Harland John Howard Inskip Griselda Jenner (nee Seggie) Jacqueline Vyvienne Keighley (nee Burch) Mary Lennox Ronald Blackwood Pridie Creasy Selabhaya Ratnatunga
Authors: J. Webster
Journal: BMJ (2000)