tbuckley/cabot-search huggingface dataset:
Prognostic value of left ventricular dyssynchrony in patients with heart failure: Reply
Authors: Stephane Garrigue, Hugues Bader
Journal: Journal of the American College of Cardiology (2004)

We thank Dr. Bax and colleagues for their interest in our study ([1][1]) and, above all, for raising several important issues. As they mentioned in their letter, various studies have demonstrated or at least suggested that left ventricular (LV) dyssynchrony might predict response to cardiac
Endovascular coil visible in a visible vessel
Authors: F. Vleggaar, D. Rutgers
Journal: Endoscopy (2007)

A 59-year-old woman collapsed while she was being admitted for chemotherapy for stage IV ovarian cancer. After large-volume resuscitation, upper gastrointestinal endoscopy was performed because of hematemesis. A large ulcer (2 × 2 cm) in the posterior wall of the duodenal bulb with a large, actively bleeding visible vessel (estimated diameter 5 - 6 mm) was seen. Despite repeated local epinephrine injections, heater probe coagulation and endoscopic clipping, arterial bleeding persisted. These endoscopic hemostatic techniques probably failed because the diameter of the bleeding vessel was too large; endoscopic visibility was bad due to persistent fulminant bleeding and the location of the ulcer [1] [2]. Emergency surgery was considered too invasive because of the patient's medical history. Angiography showed massive duodenal bleeding after contrast injection in the gastroduodenal artery. Multiple endovascular coils were successfully placed both distal and proximal to the bleeding focus. [Figure 1] shows selective angiography of the common hepatic artery. Multiple coils are present in the gastroduodenal artery, obstructing the passage of contrast fluid. The patient recovered soon after this intervention. After 4 days, upper gastrointestinal endoscopy was performed because of a slight decrease in the hemoglobin level. A coil was clearly seen in the center of the visible vessel ([Figure 2]).
TC-99m MIBI MYOCARDIAL PERFUSION SCINTIGRAPHY IN PATIENTS WITH LEFT BUNDLE BRANCH BLOCK
Authors: I. W. Gayed, W. H. Moore, W. Vaughn, M. Zaqqa, E. Giles, N. Kutka
Journal: Clinical Nuclear Medicine (1998)

Gayed, I. W.; Moore, W. H.; Vaughn, W.; Zaqqa, M.; Giles, E.; Kutka, N. Author Information
Persistent Human Papillomavirus Infection Is Associated with a Generalized Decrease in Immune Responsiveness in Older Women
Authors: Alfonso J. García-Piñeres, Allan Hildesheim, Rolando Herrero, Matthew Trivett, Marcus Williams, Ivannia Atmetlla, Margarita Ramírez, Maricela Villegas, Mark Schiffman, Ana Cecilia Rodríguez, Robert D. Burk, Mariana Hildesheim, Enrique Freer, José Bonilla, Concepción Bratti, Jay A. Berzofsky, Ligia A. Pinto
Journal: Cancer Research (2006)

Abstract The development of cervical cancer and its precursors are linked to persistent infection with oncogenic types of human papillomavirus (HPV). Host immune responses seem to be determinants of risk for this disease. However, little is known about the immunologic determinants of HPV persistence. Here, we examined the association between lymphoproliferative responses to antigens/mitogens and persistent HPV infection in women older than 45 years. Women included in this study were participants in a 10,000-woman population-based cohort study of cervical neoplasia in Costa Rica. Women older than 45 years and HPV DNA positive at a screening visit were selected as cases (n = 283). We selected a comparably sized control group of HPV DNA–negative women, matched to cases on age and time since enrollment (n = 261). At an additional clinical visit, women were cytologically and virologically rescreened, and cervical and blood specimens were collected. Proliferative responses to phytohemagglutinin (PHA), influenza virus (Flu), and HPV16 virus-like particle (VLP) were lower among women with persistent HPV infection [median counts per minute (cpm): 72,849 for PHA, 1,241 for Flu, and 727 for VLP] than for the control group (median cpm: 107,049 for PHA, 2,111 for Flu, and 2,068 for VLP). The decreases were most profound in women with long-term persistence and were only observed for the oldest age group (≥65 years). Our results indicate that an impairment in host immunologic responses is associated to persistent HPV infection. The fact that effects were evident for all studied stimuli is suggestive of a generalized effect. (Cancer Res 2006; 66(22): 11070-6)
405 SUPERSONIC SHEAR IMAGING IS A NEW POTENT MORPHOLOGICAL NON-INVASIVE TECHNIQUE TO ASSESS OF LIVER FIBROSIS. PART II: COMPARISON WITH FIBROSCAN
Authors: E. Bavu, J.-L. Gennisson, V. Mallet, B.-F. Osmanski, M. Couade, J. Bercoff, M. Fink, P. Sogni, A. Vallet-Pichard, B. Nalpas, M. Tanter, S. Pol
Journal: Journal of Hepatology (2010)
Psychometrics of the Schalling-Sifneos and Toronto Alexithymia Scales
Authors: Laurie Morrison, R.O. Pihl
Journal: Psychotherapy and Psychosomatics (1989)

Two measures of alexithymia, the Schalling-Sifneos (SSPS) and the Toronto Scales (TAS) were administered to 178 male and female undergraduate students. For both measures alexithymia appears to decrease with age. Five factors for the TAS were retained accounting for 35% of the variance and for the SSPS a three-factor solution was determined accounting for 53% of the variance. The robustness of the solution analyzed with the TAS reflected greater stability. The factor structure of the TAS seemed more consistent with the concept of alexithymia than that of the SSPS
Cimetidine and Cardiac Dysrhythmias
Authors: A. B. MEHTA
Journal: Annals of Internal Medicine (1982)

Letters and Corrections1 August 1982Cimetidine and Cardiac DysrhythmiasA. B. MEHTA, M.A., J. M. GOLDMAN, D.M.A. B. MEHTA, M.A.Search for more papers by this author, J. M. GOLDMAN, D.M.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-97-2-283_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: There are isolated reports of disturbances of cardiac rhythm occurring during treatment with both oral and intravenous Cimetidine in a variety of clinical settings (1-3). Such dysrhythmias may be due to antagonism of the action of histamine at H2 receptors in the heart and peripheral vascular system (4) but the pattern of adverse effects is variable, both in nature and in incidence (5). We have recently seen two patients in whom the dysrhythmias may have been due to Cimetidine. Both patients probably had preexisting myocardial abnormalities.A 24-year-old man with chronic granulocytic leukemia was treated with daunorubicin,...References1. JEFFREYSVALE DJ. Cimetidine and bradycardia. Lancet. 1978;1:828. CrossrefGoogle Scholar2. COHENWHEETMANDARJIEKRIKLER JAJD. Life-threatening arrhythmias and intravenous Cimetidine. Be Med J. 1979;2:768. CrossrefMedlineGoogle Scholar3. MACMAHONBAKSHIWALSH BMM. Cardiac arrhythmias after intravenous Cimetidine. N Engl J Med. 1981;305;14:832-3. CrossrefMedlineGoogle Scholar4. SAMUELDUNDEE IJ. Cardiovascular responses after intravenous Cimetidine. J R Soc Med. 1979;72:898. CrossrefMedlineGoogle Scholar5. BOYLEOWENWAREHAM DDK. Modification of cardiovascular effects of histamine infusions in man by chlorpheniramine and Cimetidine. Br J Pharmacol. 1980;70:110P. Google Scholar6. SHULMANSULLIVANWEIDEN HKP. Chronic graft versus host syndrome in man. A J Med. 1980;69:204-17. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of London London, England PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByClinical Aspects of Cardiovascular Effects of H 2 -Receptor AntagonistsDose-dependent heart rate reducing effect of nizatidine, a histamine H2- receptor antagonist.Haemodynamic effects of H 2 -receptor antagonistsHistaminwirkungen am Herzen unter besonderer Berücksichtigung kardialer Nebenwirkungen von H2-Rezeptor-AntagonistenEffect of preanesthetic famotidine on gastric volume and pHAcute Cardiovascular Effects of Intravenous Cimetidine 1 August 1982Volume 97, Issue 2Page: 283-283KeywordsArrhythmiaHeartHistamine Issue Published: 1 August 1982 PDF DownloadLoading ...
Maximizing Antiretroviral Therapy in Developing Countries
Authors: Christopher J. L. Murray
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Electrocardiography in Clinical Practice
Authors: Borys Surawicz
Journal: JAMA (1986)

When I reviewed the 1967 textbook of clinical vectorcardiography by Drs Te-Chuan Chou and Robert A. Helm (<i>JAMA</i>, Jan 15,1968), I referred to it as a "remarkable specimen of superb teaching and clear writing." I felt that the book provided convincing evidence that the vectorcardiogram constructed from corrected orthogonal leads was more than occasionally superior to the electrocardiogram in the diagnosis of myocardial infarction, hypertrophy, and various intraventricular conduction disturbances. From this, one might have predicted a bright future for orthogonal vectorcardiography, particularly when popularized by such masters as Chou and Helm. Yet, a visit to a randomly selected medical center or hospital in this country is likely to reveal that, in today's clinical practice, vectorcardiography is threatened with extinction. Whereas the symmetry of the corrected orthogonal leads and the precision of time markings in the vector loop are no less appealing today than 20 years ago, they are rarely
Women in Academic Medicine-Reply
Authors: Jane Green Schaller
Journal: JAMA (1991)

<h3>In Reply.—</h3> Drs Judi and Robert Goldstone are to be commended for their progressive attitudes and their success in combining satisfactory family lives and careers (they do not tell us whether in private practice or in academic medicine). There are doubtless other professional families like them. But this is not really the point. Despite the hopeful report from Columbia University of Nickerson et al,<sup>1</sup>disquieting evidence still suggests that women are not rising to the top in academic medicine as might be expected. In psychiatry, 19% of the faculty members in 1975 and 24% in 1989 were women, yet in 1989 only 8.5% of full professors of psychiatry were women, and currently only 0.8% (one of 127) of the chairs of psychiatry departments in the United States is a woman. In pediatrics, 28% of faculty in 1975 and 33% in 1989 were women, but in 1989 only 14% of
Plasma glutathione redox state: A novel marker of oxidative stress, correlates with early atherosclerosis in humans
Authors: Salman Ashfaq, Sean C. Beinart, Jerome L. Abramson, Steven D. Rhodes, Claudine Jurkovitz, Viola Vaccarino, Jovonne K. Williams, Dean P. Jones, Arshed A. Quyyumi, William S. Weintraub, David G. Harrison
Journal: Journal of the American College of Cardiology (2003)
Extreme warfarin sensitivity in siblings associated with multiple cytochrome P450 polymorphisms
Authors: Arash Rafii Tabrizi, Sean D. McGrath, Morey A. Blinder, Timothy G. Buchman, Barbara A. Zehnbauer, Bradley D. Freeman
Journal: American Journal of Hematology (2001)

Abstract Warfarin use is complicated by an erratic dose response. Warfarin is metabolized by two distinct subfamilies of the cytochrome P450 (CYP) complex. We describe two siblings with extreme sensitivity to warfarin who share an unusual CYP genotype. These individuals illustrate both the importance of genetics in influencing the metabolism of warfarin as well as the potential utility of genetic testing as a guide to prescribing this medication. Am. J. Hematol. 67:144–146, 2001. © 2001 Wiley‐Liss, Inc.
Alan Hutchinson Fairlamb
Authors: David Fairlamb
Journal: BMJ (2005)

Concentration camp survivor and psychiatrist who became a high profile campaigner on child abuseThe Dutch psychiatrist and psychotherapy professor Dries van Dantzig once confessed to a colleague that he survived Neuengamme concentration camp "by making myself invisible"-which makes his survival seem all the more remarkable, as later he was rarely out of the public arena as a tireless and hard hitting promoter of mental health care.Imprisonment followed by years in a tuberculosis sanatorium may have sharpened the sense of injustice that reportedly drove Van Dantzig in his later public life.Today he is remembered as a merciless debater, publicist, political lobbyist, and film critic.His refusal to take "no for an answer" ensured that mental health and especially child abuse had a higher place on the political agenda of postwar Holland than it otherwise might have had.Van Dantzig was renowned for glaring from the front row at conference speakers with whom he disagreed.He made countless television appearances, and seemed to know a remarkable number of government ministers personally.The simple theme that underpinned his career was that, compared with somatic illness, psychiatric illness was largely ignored and underfunded.He illustrated this by arguing that every year more children would be killed by abuse than would ever die from Creutzfeldt-Jakob disease, which attracted millions more in funding.He suggested that up to 30% of the population had a neurosis, and that cases of child abuse could result in 50 to 80 deaths a year.Dries van Dantzig was born in 1920 into a progressive and left leaning family in Gouda.His education in Amsterdam was disrupted as the second world war broke out while he was still in his teens.He was eventually arrested for his involvement with the resistance and sent to Neuengamme near Hamburg.Of the 5500 Dutchmen sent there only 600 survived.Van Dantzig was among the few who did because, he later claimed, he was able to blend into the background amid such horrors as collecting dead bodies to take to the ovens or eating the food of those who had died.Yet all the time he was sharpening both his observational skills and his acute sense of injustice.
Predictive value of a proteomic signature in patients with non-small-cell lung cancer treated with second-line erlotinib or chemotherapy (PROSE): a biomarker-stratified, randomised phase 3 trial
Authors: Vanesa Gregorc, Silvia Novello, Chiara Lazzari, Sandro Barni, Michele Aieta, Manlio Mencoboni, Francesco Grossi, Tommaso De Pas, Filippo de Marinis, Alessandra Bearz, Irene Floriani, Valter Torri, Alessandra Bulotta, Angela Cattaneo, Julia Grigorieva, Maxim Tsypin, Joanna Roder, Claudio Doglioni, Matteo Giaj Levra, Fausto Petrelli, Silvia Foti, Mariagrazia Viganò, Angela Bachi, Heinrich Roder
Journal: The Lancet Oncology (2014)
Participation of small intraportal stem cells in the restitutive response of the liver to periportal necrosis induced by allyl alcohol
Authors: Leonid Yavorkovsky, Eva Lai, Zoran Ilic, Stewart Sell
Journal: Hepatology (1995)

To determine the involvement of different hepatocyte populations in response to periportal injury, the restitutive response to allyl alcohol (AA) injury was examined. Adult female Sprague-Dawley rats were injected intraperitoneally (IP) with 0.62 mmol/kg AA, killed at 6, 9, 12, 33, 57, 81, and 153 hours after injection, and the livers were examined for injury and for restitutive proliferation by histology, autoradiography, and immunohistochemistry to detect alpha-fetoprotein (AFP), glutathione-s-transferase-p (GST-p), desmin, leukocyte common antigen, albumin, and monoclonal antibodies to liver cells: OV-6, H-4, and T-6. AA produces variable periportal liver necrosis predominantly at 6 to 12 hours. Proliferation of hepatocytes throughout the hepatic cord is seen early after injury in nonnecrotic areas: predominantly in zone II, but also in zones I and III, including some cells adjacent to the central vein. Within 2 to 3 days the necrotic zones are filled with small cells and by 1 week the liver architecture is essentially restored. During the active restitutive reaction from the immediate periportal rim the following cell phenotypes are seen: null cells: -->(AFP+, OV-6-, GST-p-) cells-->(AFP-, OV-6+, GST-p+) cells-->large (AFP-, OV-6-, GST-p-, H-4+) liver cells. Albumin staining was negative. We conclude that restitutive proliferation of periportal necrosis induced by AA appears to be accomplished by proliferation of intraportal (?stem) cells whose progeny differentiate and eventually repopulate the necrotic zone.
Scavenging effects of terbinafine on free radicals in vitro
Authors: None CAMERA, None CANNISTRACI, None BRIGANTI, None COLOMBO, None PICARDO
Journal: British Journal of Dermatology (1999)

One of the goals of antifungal therapy is to combine an anti-inflammatory activity with antimycotic properties, and therefore it is interesting to evaluate the capacity of active antifungal drugs to interfere with different phases of the inflammatory reaction. In order to identify a possible scavenger property of free radical species of the antifungal agent terbinafine, we studied its activity on the reduction of nitrotetrazolium blue chloride (NTB), induced by superoxide anions with the ultraviolet (UV)- and chemical-induced peroxidation of unsaturated lipid targets. NTB reduction was followed by spectrophotometer and the decomposition of squalene or methyl arachidonate by gas chromatography-mass spectrometry. Terbinafine (20 microgram and over) was capable of significantly inhibiting NTB reduction, indicating that the drug scavenges superoxide anion radicals. In these conditions no modifications of the concentration of the drug, as evaluated by high performance liquid chromatography, were observed. The UV- or chemically induced peroxidation of squalene and arachidonic acid was significantly reduced in the presence of 50 microgram of terbinafine, suggesting that the substance interferes with the chemical properties of peroxyl radicals. In all the tests used the degree of inhibition was proportional to the amount of free radicals generated. In conclusion our results indicate that terbinafine, at therapeutic concentrations, can be considered to be a free radical interceptor in vitro and could exert a mild anti-inflammatory activity in vivo.
Allograft Nephrectomy after Transplant Failure
Authors: Heidi M. Schaefer, J. Harold Helderman
Journal: Journal of the American Society of Nephrology (2010)

<h3>BACKGROUND:</h3> Initial hospital discharge to home of technology-dependent children requires extensive training and education of the family caregivers. Education of adult family members should promote positive interactions in a nonthreatening manner while facilitating the development of the knowledge and skills to competently and independently provide all aspects of the medical care. We utilize a training program for adult family members of children who have undergone tracheostomy to facilitate long-term mechanical ventilatory support and who are being prepared for their initial discharge from the hospital to home. A dedicated respiratory therapist family educator directs this program. Multiple teaching tools, activities, and training sessions, based on adult learning theory, are utilized to develop appropriate clinical skills to manage children with tracheostomies and the associated technological supports. <h3>METHODS:</h3> We evaluated the effectiveness of our program by administering a written test to caregivers, at the start and the conclusion of their training. We also surveyed the caregivers about their satisfaction with the educational program and the respiratory therapist family educator9s performance. We also surveyed employees of the durable medical equipment companies used by the families, regarding the caregivers9 knowledge and competency in the home one month following discharge. <h3>RESULTS:</h3> Our program was associated with a statistically significant improvement in caregiver test performance, and the caregivers expressed a high degree of satisfaction with the program. The employees of the durable medical equipment companies perceived a high degree of knowledge and competence on the part of the home caregivers. <h3>CONCLUSION:</h3> Our training program appears to have a positive impact on the educational preparation of caregivers.
Intestinal Absorption — Aspects of Structure, Function and Disease of the Small-Intestine Mucosa
Authors: Leonard Laster, Franz J. Ingelfinger
Journal: New England Journal of Medicine (1961)

MalabsorptionIt is apparent from the preceding discussion that intestinal absorption is the net result of many interdependent physicochemical and biochemical reactions. Since these reactions are potentially vulnerable to disruption by one or more pathologic processes, the general mechanisms that may be responsible for malabsorption are numerous and varied. These mechanisms have been well described and categorized in recent reviews,117 118 119 120 121 122 123 124 125 126 127 and this discussion will not enter upon malabsorption caused by impaired digestive function, deranged motility, excessive secretion (exudative enteropathy) or inadequate small-bowel absorptive surface curtailed by inflammation, infiltration or ablation. Instead, emphasis will be placed on certain aspects of the . . .