tbuckley/cabot-search huggingface dataset:
Outcomes of adrenal-sparing surgery or total adrenalectomy in phaeochromocytoma associated with multiple endocrine neoplasia type 2: an international retrospective population-based study
Authors: Frederic Castinetti, Xiao-Ping Qi, Martin K Walz, Ana Luiza Maia, Gabriela Sansó, Mariola Peczkowska, Kornelia Hasse-Lazar, Thera P Links, Sarka Dvorakova, Rodrigo A Toledo, Caterina Mian, Maria Joao Bugalho, Nelson Wohllk, Oleg Kollyukh, Letizia Canu, Paola Loli, Simona R Bergmann, Josefina Biarnes Costa, Ozer Makay, Attila Patocs, Marija Pfeifer, Nalini S Shah, Thomas Cuny, Michael Brauckhoff, Birke Bausch, Ernst von Dobschuetz, Claudio Letizia, Marcin Barczynski, Maria K Alevizaki, Malgorzata Czetwertynska, M Umit Ugurlu, Gerlof Valk, John T M Plukker, Paola Sartorato, Debora R Siqueira, Marta Barontini, Malgorzata Szperl, Barbara Jarzab, Hans H G Verbeek, Tomas Zelinka, Petr Vlcek, Sergio P A Toledo, Flavia L Coutinho, Massimo Mannelli, Monica Recasens, Lea Demarquet, Luigi Petramala, Svetlana Yaremchuk, Dmitry Zabolotnyi, Francesca Schiavi, Giuseppe Opocher, Karoly Racz, Andrzej Januszewicz, Georges Weryha, Jean-Francois Henry, Thierry Brue, Bernard Conte-Devolx, Charis Eng, Hartmut P H Neumann
Journal: The Lancet Oncology (2014)
Applicability of a cryogradient technique for the enrichment of PAH from automobile exhausts: demonstration of methodology and evaluation experiments.
Authors: U Stenberg, T Alsberg, R Westerholm
Journal: Environmental Health Perspectives (1983)

A cryogradient system for the enrichment of polycyclic aromatic hydrocarbons from gasoline and diesel powered vehicles is described. The sampling involves particle trapping on a filter followed by gas phase enrichment in three separate condensers. The filter is extracted with dichloromethane (DCM). For the extraction of the condensers three different solvents have been used; cyclohexane, acetone and DCM. The latter has also been used together with three buffers, pH 3, pH 7 and pH 11. Analyses of polynuclear aromatic hydrocarbons were performed by means of glass capillary gas chromatography and mass spectrometry. These analyses of diluted gasoline exhausts show that of the phenanthrene/anthracene, fluoranthene/pyrene and their monoalkylated forms found, between 90 and 30% are present in the gas phase. For diesel emissions, corresponding values are between 50% and 5%, respectively. However, the distribution of PAH between gas phase and particles is dependent on dilution ratio and filter temperatures. The addition of NO2 (approximately 7 ppm) prior to filter sampling involves degradation of cyclopenteno(cd)pyrene (CPedP) and benzo(a)pyrene (BaP) on the particles from diluted gasoline exhausts. This also occurs with BaP on diesel particles sampled under equivalent conditions. Mutagenicity data from these experiments support the theory of formation of direct-acting mutagens, probably due to nitration. Parallel sampling of particles with Teflon-coated and glass fiber filters does not show that components which are reactive to NO2, e.g., CPcdP, are degraded to a lower extent when glass fiber filters are used.
Retrieval-specific endocytosis of GluA2-AMPARs underlies adaptive reconsolidation of contextual fear
Authors: Priyanka Rao-Ruiz, Diana C Rotaru, Rolinka J van der Loo, Huibert D Mansvelder, Oliver Stiedl, August B Smit, Sabine Spijker
Journal: Nature Neuroscience (2011)
PASSIVE TRANSFER OF CONTACT SENSITIVITY BY TRITIATED THYMIDINE-LABELED LYMPHOID CELLS
Authors: John S. Najarian, Joseph D. Feldman
Journal: The Journal of Experimental Medicine (1963)

Passive transfer of tritiated thymidine-labeled lymphoid cells sensitized to the simple chemical DNFB into homologous guinea pigs resulted in positive contact skin reactions 24 hours after skin testing with DNFB. Labeled sensitized cells were found to accumulate at these sites, whereas, labeled nonsensitized lymphoid cells did not appear non-specifically in contact skin reaction sites. The labeled cells were small and large lymphocytes and immature cells of the lymphoid series. The maximum reactions were obtained at 24 hours, with an average of 3.4 per cent of the infiltrating mononuclear cells showing a label. At 48 hours, the macro- and microscopic reactions were similar to the 24 hour reactions but diminished in intensity, and the number of labeled cells in the infiltrates had decreased to 1 per cent of the total infiltrating mononuclear cells. (1/4) to (1/3) of the labeled cells were found within the epidermis in the test skin sites. These data have indicated that contact sensitivity, like tuberculin sensitivity, required the sensitized cell to initiate the skin reaction and that the majority of the cellular infiltrate was the result of non-specific host response to injury.
Epigenetic regulation in murine offspring as a novel mechanism for transmaternal asthma protection induced by microbes
Authors: Stephanie Brand, René Teich, Tanja Dicke, Hani Harb, Ali Ö. Yildirim, Jörg Tost, Regine Schneider-Stock, Robert A. Waterland, Uta-Maria Bauer, Erika von Mutius, Holger Garn, Petra I. Pfefferle, Harald Renz
Journal: Journal of Allergy and Clinical Immunology (2011)
An acute multiorgan thrombotic disorder associated with antiphospholipid antibodies; two `catastrophic' cases
Authors: C. BOERMA, R. DERKSEN, B. VAN DER WIEL
Journal: Annals of the Rheumatic Diseases (1997)

Over the past decade the antiphospholipid syndrome (APS) was defined by the presence of antiphospholipid antibodies (aPL) and clinical manifestations including thrombosis, recurrent fetal loss, thrombocytopenia, chorea, livedo reticularis, heart valve lesions, and renal involvement.1 Asherson et al first drew attention to a catastrophic variant of APS (CAPS) that is characterised by multiple widespread vascular occlusions, leading to multiple organ failure and often death.2 We describe two non-systemic lupus erythematosus (SLE) patients with a strikingly similar clinical presentation of CAPS and emphasise the difficulties in differentiating CAPS from other thrombotic angiopathies.

### CASE REPORT ONE

A 20 year old woman presented with transient hemichorea in 1993. Computed tomography of the brain was normal. From June 1995, episodes of hemichorea reoccurred together with severe frontal headaches. In November 1995 she was admitted to our hospital with rapid deterioration of vision and behavioural changes.

Physical examination showed subcoma, blood pressure 150/115 mm Hg, livedo reticularis, ischaemic skin ulcerations, and a systolic cardiac murmur. Fundoscopy showed arteriolar occlusions, bleeding, and exudates.

Laboratory findings included: platelet count 47 × …
Postnatal growth standards for preterm infants: the Preterm Postnatal Follow-up Study of the INTERGROWTH-21 st Project
Authors: José Villar, Francesca Giuliani, Zulfiqar A Bhutta, Enrico Bertino, Eric O Ohuma, Leila Cheikh Ismail, Fernando C Barros, Douglas G Altman, Cesar Victora, Julia A Noble, Michael G Gravett, Manorama Purwar, Ruyan Pang, Ann Lambert, Aris T Papageorghiou, Roseline Ochieng, Yasmin A Jaffer, Stephen H Kennedy
Journal: The Lancet Global Health (2015)

Charts of size at birth are used to assess the postnatal growth of preterm babies on the assumption that extrauterine growth should mimic that in the uterus.The INTERGROWTH-21(st) Project assessed fetal, newborn, and postnatal growth in eight geographically defined populations, in which maternal health care and nutritional needs were met. From these populations, the Fetal Growth Longitudinal Study selected low-risk women starting antenatal care before 14 weeks' gestation and monitored fetal growth by ultrasonography. All preterm births from this cohort were eligible for the Preterm Postnatal Follow-up Study, which included standardised anthropometric measurements, feeding practices based on breastfeeding, and data on morbidity, treatments, and development. To construct the preterm postnatal growth standards, we selected all live singletons born between 26 and before 37 weeks' gestation without congenital malformations, fetal growth restriction, or severe postnatal morbidity. We did analyses with second-degree fractional polynomial regression models in a multilevel framework accounting for repeated measures. Fetal and neonatal data were pooled from study sites and stratified by postmenstrual age. For neonates, boys and girls were assessed separately.From 4607 women enrolled in the study, there were 224 preterm singleton births, of which 201 (90%) were enrolled in the Preterm Postnatal Follow-up Study. Variance component analysis showed that only 0·2% and 4·0% of the total variability in postnatal length and head circumference, respectively, could be attributed to between-site differences, justifying pooling the data from all study sites. Preterm growth patterns differed from those for babies in the INTERGROWTH-21(st) Newborn Size Standards. They overlapped with the WHO Child Growth Standards for term babies by 64 weeks' postmenstrual age.Our data have yielded standards for postnatal growth in preterm infants. These standards should be used for the assessment of preterm infants until 64 weeks' postmenstrual age, after which the WHO Child Growth Standards are appropriate. Size-at-birth charts should not be used to measure postnatal growth of preterm infants.Bill & Melinda Gates Foundation.
The Use of Medical Hyperspectral Technology to Evaluate Microcirculatory Changes in Diabetic Foot Ulcers and to Predict Clinical Outcomes
Authors: Lalita Khaodhiar, Thanh Dinh, Kevin T. Schomacker, Svetlana V. Panasyuk, Jenny E. Freeman, Robert Lew, Tiffany Vo, Alexander A. Panasyuk, Christina Lima, John M. Giurini, Thomas E. Lyons, Aristidis Veves
Journal: Diabetes Care (2007)

Foot ulceration is a serious complication of diabetes, and new techniques that can predict wound healing may prove very helpful. We tested the ability of medical hyperspectral technology (HT), a novel diagnostic scanning technique that can quantify tissue oxy- and deoxyhemoglobin to predict diabetic foot ulcer healing.Ten type 1 diabetic patients with 21 foot ulcer sites, 13 type 1 diabetic patients without ulcers, and 14 nondiabetic control subjects were seen up to 4 times over a 6-month period. HT measurements of oxyhemoglobin (HT-oxy) and deoxyhemoglobin (HT-deoxy) were performed at or near the ulcer area and on the upper and lower extremity distant from the ulcer. An HT healing index for each site was calculated from the HT-oxy and -deoxy values.Hyperspectral tissue oxygenation measurements observed changes in tissue immediately surrounding the ulcer when comparing ulcers that heal and ulcers that do not heal (P < 0.001). The sensitivity, specificity, and positive and negative predictive values of the HT index for predicting healing were 93, 86, 93, and 86%, respectively, when evaluated on images taken at the first visit. Changes in HT-oxy among the three risk groups were noted for the metatarsal area of the foot (P < 0.05) and the palm (P < 0.01). Changes in HT-deoxy and the HT healing index were noted for the palm only (P < 0.05 and P < 0.01, respectively).HT has the capability to identify microvascular abnormalities and tissue oxygenation in the diabetic foot and predict ulcer healing. HT can assist in the management of foot ulceration.
The role of dermal blood vessels in the pathogenesis of malignant atrophic papulosis (Degos' disease).
Authors: MARTIN M. BLACK, KIYOSHI NISHIOKA, GERALD M. LEVENE
Journal: British Journal of Dermatology (1973)

Journal Article The role of dermal blood vessels in the pathogenesis of malignant atrophic papulosis (Degos' disease): A STUDY OF TWO CASES USING ENZYME HISTOCHEMICAL, FIBRINOLYTIC, ELECTRON‐MICROSCOPICAL AND IMMUNOLOGICAL TECHNIQUES Get access MARTIN M. BLACK, MARTIN M. BLACK Department of Histopathology, Institute of Dermatology, London WC2H 7BJ, and Department of Immunology, Institute of Dermatology, Homerton Grove, London E9 6BX Search for other works by this author on: Oxford Academic Google Scholar KIYOSHI NISHIOKA, KIYOSHI NISHIOKA Department of Histopathology, Institute of Dermatology, London WC2H 7BJ, and Department of Immunology, Institute of Dermatology, Homerton Grove, London E9 6BX Search for other works by this author on: Oxford Academic Google Scholar GERALD M. LEVENE GERALD M. LEVENE Department of Histopathology, Institute of Dermatology, London WC2H 7BJ, and Department of Immunology, Institute of Dermatology, Homerton Grove, London E9 6BX Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 88, Issue 3, 1 March 1973, Pages 213–219, https://doi.org/10.1111/j.1365-2133.1973.tb07537.x Published: 01 March 1973 Article history Accepted: 17 August 1972 Published: 01 March 1973
RETRACTED ARTICLE: Genomic amplification and high expression of EGFR are key targetable oncogenic events in malignant peripheral nerve sheath tumor
Authors: Xiaoling Du, Jilong Yang, Antti Ylipää, Ze Zhu
Journal: Journal of Hematology & Oncology (2013)

The dismal outcome of malignant peripheral nerve sheath tumor (MPNST) highlights the necessity of finding new therapeutic methods to benefit patients with this aggressive sarcoma. Our purpose was to investigate epidermal growth factor receptor (EGFR) as a potential therapeutic target in MPNSTs.We performed a microarray based-comparative genomic hybridization (aCGH) profiling of two cohorts of primary MPNST tissue samples including 25 patients treated at The University of Texas MD Anderson Cancer Center (MD Anderson) and 26 patients from Tianjin Medical University Cancer Institute & Hospital (TMUCIH). Fluorescence in situ hybridization (FISH) method was used to validate the gene amplification detected by aCGH analysis. Another independent cohort of 56 formalin fixed paraffin embedded (FFPE) MPNST samples was obtained to explore EGFR protein expression by immunohistochemical analysis. Cell biology detection and validation were performed on human MPNST cell lines ST88-14 and STS26T.aCGH and pathway analysis of the 51 MPNSTs identified significant gene amplification events in EGFR pathway, including frequent amplifications of EGFR gene itself, which was subsequently validated by FISH assay. High expression of EGFR protein was associated with poor disease-free and overall survival of human MPNST patients. In human MPNST cell lines ST88-14 and STS26T, inhibition of EGFR by siRNA or Gefitinib led to decreased cell proliferation, migration, and invasion accompanied by attenuation of PI3K/AKT and MAPK pathways.These results suggest that EGFR is a potential therapeutic target for MPNST.
Haematological consequences of methotrexate therapy
Authors: H. Baker
Journal: British Journal of Dermatology (1986)

Journal Article Haematological consequences of methotrexate therapy Get access H. Baker H. Baker The London Hospital, Whitechapel, London E1 1BB, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 115, Issue 2, 1 August 1986, Page 253, https://doi.org/10.1111/j.1365-2133.1986.tb05731.x Published: 01 August 1986
Intentional relations and social understanding
Authors: John Barresi, Chris Moore
Journal: Behavioral and Brain Sciences (1996)

Abstract Organisms engage in various activities that are directed at objects, whether real or imagined. Such activities may be termed “intentional relations.” We present a four-level framework of social understanding that organizes the ways in which social organisms represent the intentional relations of themselves and other agents. We presuppose that the information available to an organism about its own intentional relations (or first person information) is qualitatively different from the information available to that organism about other agents’ intentional relations (or third person information). However, through the integration of these two sources of information, it is possible to generate representations of intentional relations that are uniformly applicable to the activities of both self and other. The four levels of the framework differ in the extent to which such integration occurs and in the degree to which imagination is involved in generating these representations. Most animals exist at the lowest level, at which integration of first and third person sources of information does not occur. Of nonhuman species, only great apes exhibit social understanding at intermediate levels, at which integration of these sources of information provides uniform representations of intentional relations. Only humans attain the highest level, at which it is possible to represent intentional relations with mental objects. We propose that with the development of the imagination, children progress through three stages, equivalent to the later three levels of the framework. The abnormalities in social understanding of autistic individuals are hypothesized to result from a failure to develop integrated representations of intentional relations.
Melastatin Expression and Prognosis in Cutaneous Malignant Melanoma
Authors: Lyn M. Duncan, James Deeds, Frank E. Cronin, Michael Donovan, Arthur J. Sober, Michael Kauffman, Jeanette J. McCarthy
Journal: Journal of Clinical Oncology (2001)

Melastatin (MLSN-1), a novel melanocyte-specific gene recently identified using a genomic approach, is expressed in murine and human melanoma cells at levels inversely proportional to metastatic rates in vivo. We studied the relationship between expression of melastatin mRNA in the primary cutaneous tumor and prognosis in patients with localized malignant melanoma.Melastatin mRNA was evaluated by in situ hybridization in primary cutaneous melanoma from 150 patients with localized disease (American Joint Committee on Cancer [AJCC] stage I and II). Multivariate Cox proportional hazards regression analysis was performed to assess the prognostic utility of melastatin mRNA expression while adjusting for other prognostic indicators.Uniform melastatin mRNA expression in the primary tumor was correlated with prolonged disease-free survival (P < .0001). Multivariate analysis revealed that melastatin status, mitotic rate, and tumor thickness influence disease-free survival independently. The 8-year disease-free survival rate in AJCC stage I patients whose tumors diffusely expressed melastatin mRNA was 100%, whereas in stage I patients with melastatin loss, the disease-free survival rate was 77% +/- 15% (median +/- SE). In patients with stage II disease whose tumors diffusely expressed melastatin mRNA, the 8-year disease-free survival rate was 90% +/- 7%, whereas in patients with melastatin loss, the disease-free survival rate was 51% +/- 8%.Downregulation of melastatin mRNA in the primary cutaneous tumor is a prognostic marker for metastasis in patients with localized malignant melanoma and is independent of tumor thickness and other variables. Used in combination, melastatin status and tumor thickness allow for the identification of subgroups of patients at high and low risk of developing metastatic disease.
Cerebrospinal Fluid Amine Metabolites in Affective Illness: The Probenecid Technique
Authors: FREDERICK K. GOODWIN, ROBERT M. POST, DAVID L. DUNNER, EDNA K. GORDON
Journal: American Journal of Psychiatry (1973)

Probenecid inhibits the removal of 5-HIAA and HVA (the major metabolites of serotonin and dopamine) from the cerebrospinal fluid. The accumulation of these metabolites following high doses of probenecid was studied in patients with affective illness in order to assess central amine function. The metabolite accumulation was increased by administering the appropriate precursors (which increase amine synthesis) and was decreased by administering specific synthesis inhibitors. Compared with controls, the depressed patients had low HVA accumulation, while addicts on methadone had low 5-HIAA accumulation. Within the group of depressed patients, HVA accumulation was higher in bipolar than in unipolar patients.
Comparative Mortality Associated With Ziprasidone and Olanzapine in Real-World Use Among 18,154 Patients With Schizophrenia: The Ziprasidone Observational Study of Cardiac Outcomes (ZODIAC)
Authors: Brian L. Strom, Sybil M. Eng, Gerald Faich, Robert F. Reynolds, Ralph B. D'Agostino, Jeremy Ruskin, John M. Kane
Journal: American Journal of Psychiatry (2010)

The authors compared 1-year mortality rates associated with ziprasidone and olanzapine in real-world use.The Ziprasidone Observational Study of Cardiac Outcomes (ZODIAC) was an open-label, randomized, postmarketing large simple trial that enrolled patients with schizophrenia (N=18,154) in naturalistic practice in 18 countries. The primary outcome measure was nonsuicide mortality in the year after initiation of assigned treatment. Patients were randomly assigned to receive treatment with either ziprasidone or olanzapine and followed for 1 year by unblinded investigators providing usual care. A physician-administered questionnaire was used to collect baseline demographic information, medical and psychiatric history, and concomitant medication use. Follow-up information on hospitalizations and emergency department visits, patients' vital status, and current antipsychotic drug status was collected and reported by treating psychiatrists. Post hoc analyses of sudden death, a secondary endpoint, were also conducted.The incidence of nonsuicide mortality within 1 year of initiating pharmacotherapy was 0.91 for ziprasidone (N=9,077) and 0.90 for olanzapine (N=9,077). The relative risk was 1.02 (95% CI=0.76-1.39). This finding was confirmed in numerous secondary and sensitivity analyses.Despite the known risk of QTc prolongation with ziprasidone treatment, the findings of this study failed to show that ziprasidone is associated with an elevated risk of nonsuicidal mortality relative to olanzapine in real-world use; the study excludes a relative risk larger than 1.39 with a high probability. However, the study was neither powered nor designed to examine the risk of rare events like torsade de pointes.
Lipoprotein Apheresis in Patients With Maximally Tolerated Lipid-Lowering Therapy, Lipoprotein(a)-Hyperlipoproteinemia, and Progressive Cardiovascular Disease
Authors: Josef Leebmann, Eberhard Roeseler, Ulrich Julius, Franz Heigl, Ralf Spitthoever, Dennis Heutling, Paul Breitenberger, Winfried Maerz, Walter Lehmacher, Andreas Heibges, Reinhard Klingel
Journal: Circulation (2013)

Lipoprotein(a) (Lp(a)) hyperlipoproteinemia is a major risk factor for cardiovascular disease, which is not affected by treatment of other cardiovascular risk factors. This study sought to assess the effect of chronic lipoprotein apheresis (LA) on the incidence of cardiovascular events in patients with progressive cardiovascular disease receiving maximally tolerated lipid-lowering treatment.In a prospective observational multicenter study, 170 patients were investigated who commenced LA because of Lp(a)-hyperlipoproteinemia and progressive cardiovascular disease. Patients were characterized regarding plasma lipid status, lipid-lowering drug treatment, and variants at the LPA gene locus. The incidence rates of cardiovascular events 2 years before (y-2 and y-1) and prospectively 2 years during LA treatment (y+1, y+2) were compared. The mean age of patients was 51 years at the first cardiovascular event and 57 years at the first LA. Before LA, mean low-density lipoprotein cholesterol and Lp(a) were 2.56±1.04 mmol·L(-1) (99.0±40.1 mg·dL(-1)) and Lp(a) 3.74±1.63 µmol·L(-1) (104.9±45.7 mg·dL(-1)), respectively. Mean annual rates for major adverse coronary events declined from 0.41 for 2 years before LA to 0.09 for 2 years during LA (P<0.0001). Event rates including all vascular beds declined from 0.61 to 0.16 (P<0.0001). Analysis of single years revealed increasing major adverse coronary event rates from 0.30 to 0.54 (P=0.001) for y-2 to y-1 before LA, decline to 0.14 from y-1 to y+1 (P<0.0001) and to 0.05 from y+1 to y+2 (P=0.014).In patients with Lp(a)-hyperlipoproteinemia, progressive cardiovascular disease, and maximally tolerated lipid-lowering medication, LA effectively lowered the incidence rate of cardiovascular events.https://drks-neu.uniklinik-freiburg.de. Unique identifier: DRKS00003119.