tbuckley/cabot-search huggingface dataset:
Cyclin-dependent kinases
Authors: Marcos Malumbres
Journal: Genome biology (2014)

Cyclin-dependent kinases (CDKs) are protein kinases characterized by needing a separate subunit - a cyclin - that provides domains essential for enzymatic activity. CDKs play important roles in the control of cell division and modulate transcription in response to several extra- and intracellular cues. The evolutionary expansion of the CDK family in mammals led to the division of CDKs into three cell-cycle-related subfamilies (Cdk1, Cdk4 and Cdk5) and five transcriptional subfamilies (Cdk7, Cdk8, Cdk9, Cdk11 and Cdk20). Unlike the prototypical Cdc28 kinase of budding yeast, most of these CDKs bind one or a few cyclins, consistent with functional specialization during evolution. This review summarizes how, although CDKs are traditionally separated into cell-cycle or transcriptional CDKs, these activities are frequently combined in many family members. Not surprisingly, deregulation of this family of proteins is a hallmark of several diseases, including cancer, and drug-targeted inhibition of specific members has generated very encouraging results in clinical trials.
Quasiperiodicity and chaos in cardiac fibrillation.
Authors: A Garfinkel, P S Chen, D O Walter, H S Karagueuzian, B Kogan, S J Evans, M Karpoukhin, C Hwang, T Uchida, M Gotoh, O Nwasokwa, P Sager, J N Weiss
Journal: Journal of Clinical Investigation (1997)

In cardiac fibrillation, disorganized waves of electrical activity meander through the heart, and coherent contractile function is lost. We studied fibrillation in three stationary forms: in human chronic atrial fibrillation, in a stabilized form of canine ventricular fibrillation, and in fibrillation-like activity in thin sheets of canine and human ventricular tissue in vitro. We also created a computer model of fibrillation. In all four studies, evidence indicated that fibrillation arose through a quasiperiodic stage of period and amplitude modulation, thus exemplifying the "quasiperiodic transition to chaos" first suggested by Ruelle and Takens. This suggests that fibrillation is a form of spatio-temporal chaos, a finding that implies new therapeutic approaches.
Clinical application of neuromuscular techniques: volume 1 the upper body
Authors: H Wajswelner
Journal: British Journal of Sports Medicine (2005)

Edited by Leon Chaitow, Judith Walker DeLaney. Churchill Livingstone, 2000, £45.99, pp 469, hardcover. ISBN 0443062706

As stated on page 2, imagine removing all the organs of the body, leaving only the connective tissue. What would remain would still resemble the human form, and its function could be readily appreciated, whereas doing the opposite would leave an unrecognisable collection of organs, devoid of form or function. Although there is little scientific evidence presented, such as controlled therapeutic trials, as to why these techniques are effective, this impressive first volume lights the way for practitioners of muscle energy techniques (METs), well …
Dual imaging-guided photothermal/photodynamic therapy using micelles
Authors: Miao Guo, Huajian Mao, Yanli Li, Aijun Zhu, Hui He, Hong Yang, Yangyun Wang, Xin Tian, Cuicui Ge, Qiaoli Peng, Xiaoyong Wang, Xiangliang Yang, Xiaoyuan Chen, Gang Liu, Huabing Chen
Journal: Biomaterials (2014)
Gallium Scanning and Melanoma
Authors: Brian C. Lentle, F.I. Jackson, T.A. Mcpherson
Journal: Annals of Internal Medicine (1983)

Letters and Corrections1 June 1983Gallium Scanning and MelanomaBRIAN C. LENTLE, M.D., F.I. JACKSON, M.B., T.A. MCPHERSON, M.D.BRIAN C. LENTLE, M.D.Search for more papers by this author, F.I. JACKSON, M.B.Search for more papers by this author, T.A. MCPHERSON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-98-6-1025_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Kirkwood and his colleagues do an injustice in reflecting that our data on the same subject lack validation (1). The validation is explicitly spelled out in our article as being derived from biopsy in five patients, major surgery in seven, autopsy in seven, and radiographic examination with or without clinical evidence in eight (2).Like your contributors, we were not able to correlate every individual site of disease with objective evidence of metastases, but we explicitly examined this limitation by showing, using censored survival rates, that an abnormal67Ga-citrate scan was associated with a shorter survival time....References1. KIRKWOOD J, MYERS J, and VLOCK D. Tomographic gallium-67 citrate scanning: useful new surveillance for metastatic melanoma. Ann Intern Med. 1982;97:694-9. LinkGoogle Scholar2. JACKSON F, MCPHERSON T, and LENTLE B. Gallium-67 scintigraphy in multisystem malignant melanoma. Radiology. 1977;122:163-7. CrossrefMedlineGoogle Scholar3. SHYSH A, MALLET-PARET S, LENTLE B, JACKSON F, MCPHERSON T, and JOHNSON G. Influence of intradermal BCG on the biodistribution of radiogallium in mice. Int J Nucl Med Biol. 1981;8:349-56. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: BRIAN C. LENTLE, M.D.; F.I. JACKSON, M.B.; T.A. MCPHERSON, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1983Volume 98, Issue 6Page: 1025-1025KeywordsAutopsyBiopsyMelanomaSurgery ePublished: 1 December 2008 Issue Published: 1 June 1983 PDF downloadLoading ...
THE LYSIS OF GROUP A HEMOLYTIC STREPTOCOCCI BY EXTRACELLULAR ENZYMES OF STREPTOMYCES ALBUS
Authors: Maclyn McCarty
Journal: The Journal of Experimental Medicine (1952)

The lysis of group A hemolytic streptococci by extracellular enzymes of Streptomyces albus has been studied. The most favorable material for fractionation of the lytic enzymes was obtained by surface growth on shallow layers of liquid medium containing an acid hydrolysate of casein, glucose, and salts. The results of fractionation experiments show that the potent proetolytic enzyme of Streptomyces albus is not able to lyse group A streptococci, and that the initiation of lysis is dependent upon the action of a second, non-proteolytic enzyme. The nature of the non-proteolytic enzyme has not been determined. It does not appear to be a ribonuclease or a lysozyme-like enzyme.
ADVANTAGES TO THE DIABETIC OF A DIET RICH IN CARBOHYDRATES
Authors: J. A. Nixon
Journal: BMJ (1930)

Buit eveni if we admiiit that oirationis aic but em1lpty woirds, there exi-sts a far more v-ital evidence that.the torch of inspired entlhusiasnm Is been faithfullyliaiided down from hlis day until now.First, there was thlat (lear ol(1 man Clift, wN-ho like a watch-dog guard(ed his imister's tr'casmres after lhis deatli, when it seemiied that nobody wanitel thliem.For seven years lie liv-ed oii seven shillings a1 wl-eelk, wlhilst lhe kept hiis trust, a111 tlheni later became tlhc first formal (ustodiai of the Multseumiii.The w-atch-dog growvle(l ami(i showed hiis teeth, hut, alas! could (lo no miiore whlien lhis miiaster-'s preciouts papers, miianiy of wh}iel Clift hia(d lhiimlself helped to write, were carted away and seerctly destroyed by HomIie.Clift's (laughterl iairied Richard Oweni, hlo succeeded him in the guard(lianslip of tIme Huniter AtIsecuni anid became the greatest p)ala(ontologist and eomiparativ e anatomist of hiis (lay..He wa-s later transferred to the Natural Histor v Mu.seum at South Kentsinigton.Owen wi-as followedl byPage,(t, a miost niotable torchbearer, whiose ceaseless labours d(lhed no mutell to surgical pathology, .and(iwhose silver- tolngued eloqutelince is remIembered lb many niowv lix-ivig.Tlihen caine tlhe greatest of Huntelr's followers, Lister, wlhose name is held in hionour all tIe world over as the o01e whllose wor'k hias sa.-ed miiore lives anid sufferinig than hav-e been sacrificed by war.Lister it is tirue never liel1 higlh office in this College, tlhoutglh lie was a miiemilber of Couincil foI eight ycars18.His genitle sou1l di(d niot love fighltingr witlh his; detractors, and lie preferred to lpm1Psue1 hlis quiet researchl in. the laboratoryv and at the bedside.Anid lastly, we aire forttmiate in hnaving to-dav, in the per.so of ouir beloved Curi.ator,Sir Arthluiir Keithl, one on 'Whom tlhe miianttle of Jolmi -Hunter seems perfectly to rest, thle deptlh of wlhose lealrinig and the eloquienice of wlhose tomigue fit him so well to be the gui'ardiani of Huniter's lheritage and the exponent of Huinter's inispirationi.Hiunter may tru1ly' be saidl to have raised the idea of Ilie scienitific pursuit of trutilt to tIme level of that comipelling influence in inme's lives wvhich is called religionl.1For lie lhad a vivid faith in Iiis quiest, an uniiquienchable entluisiasinS for hiis ideal li left aim inispiration for all vilo come aftei himil, amid a real hiero for uis to worshibp.
Effect of intermittent high altitude hypoxia on the synthesis of collagenous and non-collagenous proteins of the right and left ventricular myocardium
Authors: B. OSTADAL, E. MIREJOVSKA, J. HURYCH, V. PELOUCH, J. PROCHAZKA
Journal: Cardiovascular Research (1978)

Journal Article Effect of intermittent high altitude hypoxia on the synthesis of collagenous and non-collagenous proteins of the right and left ventricular myocardium Get access B. OŠŤÁDAL, B. OŠŤÁDAL 1 From the Institute of Physiology, Czechoslovak Academy of Sciences and Institute of Hygiene and Epidemiology, Prague 1Address for reprints: Dr Bohuslav OSfadal, CSc, Institute of Physiology, Czechoslovak Academy of Sciences, Bude-jovicka 1083, 142 20 Prague 4—Krc, Czechoslovakia. Search for other works by this author on: Oxford Academic PubMed Google Scholar E. MIŘEJOVSKÁ, E. MIŘEJOVSKÁ From the Institute of Physiology, Czechoslovak Academy of Sciences and Institute of Hygiene and Epidemiology, Prague Search for other works by this author on: Oxford Academic PubMed Google Scholar J. HURYCH, J. HURYCH From the Institute of Physiology, Czechoslovak Academy of Sciences and Institute of Hygiene and Epidemiology, Prague Search for other works by this author on: Oxford Academic PubMed Google Scholar V. PELOUCH, V. PELOUCH From the Institute of Physiology, Czechoslovak Academy of Sciences and Institute of Hygiene and Epidemiology, Prague Search for other works by this author on: Oxford Academic PubMed Google Scholar J. PROCHÁZKA J. PROCHÁZKA From the Institute of Physiology, Czechoslovak Academy of Sciences and Institute of Hygiene and Epidemiology, Prague Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 12, Issue 5, May 1978, Pages 303–308, https://doi.org/10.1093/cvr/12.5.303 Published: 01 May 1978
Withdrawing and withholding life support in the intensive care unit: a Spanish prospective multi-centre observational study
Authors: Andrés Esteban, Federico Gordo, Luis Solsona, Inmaculada Alía, José Caballero, Carmen Bouza, Juan Alcalá-Zamora, Deborah J. Cook, Juan M. Sanchez, Ricardo Abizanda, Gloria Miró, María J. Fernández del Cabo, Eva de Miguel, Jose A. Santos, Begoña Balerdi
Journal: Intensive Care Medicine (2001)
To Breathe or Not to Breathe
Authors: Mary Ellen Avery, Ivan D. Frantz
Journal: New England Journal of Medicine (1977)

Apneic spells, often observed in premature infants, are most frequent in those of lowest gestational age. They are much less common in infants born at term and are rarely noted among normal infants in the months after birth. Occasionally, however, apnea occurs in otherwise healthy infants several months old, who may be capable of resuscitation, and such apneic episodes are considered "near-miss" sudden infant death. Since some of these infants subsequently become victims of sudden and unexplained infant death, they are of extraordinary interest as candidates for study to detect infants at risk of sudden death. It should be noted, . . .
Emphasis: Clinical Practice
Authors: Barkley Beidleman
Journal: New England Journal of Medicine (1967)

IT is usually agreed that within a very few years, the general practitioner, as commonly defined, will have become an anachronism, an organism as defunct as the Great Auk. Various commissions and committees, citizens' and otherwise,1 2 3 4 5 are attempting to redefine, retrain, reinflate and refurbish the fading figure of the general practitioner into a personal family physician for primary comprehensive care, a general medical specialist6 or some similar euphemistically disguised reincarnation.It can be stated very simply that the need for these efforts does not exist. Admittedly, there are not enough physicians in the United States,7 there is a maldistribution of . . .
Learning theory, feed-forward mechanisms, and the adaptiveness of conditioned responding
Authors: Peter D. Balsam, Michael R. Drew
Journal: Behavioral and Brain Sciences (2004)

The specific mechanisms whereby Pavlovian conditioning leads to adaptive behavior need to be elaborated. There is no evidence that it is via reduction in the “destabilizing effect that time lags have on feedback control” (Domjan et al. 2000, sect. 3.3). The adaptive value of Pavlovian conditioning goes well beyond the regulation of social behavior.
Effects of heptanol, class Ic, and class III drugs on reentrant ventricular tachycardia. Importance of the excitable gap for the inducibility of double-wave reentry.
Authors: L Boersma, J Brugada, H Abdollah, C Kirchhof, M Allessie
Journal: Circulation (1994)

Double-wave reentry (DWR) can be a mechanism for acceleration of ventricular tachycardia (VT) with a large excitable gap (EG). The purpose of this study was to determine the effects of heptanol, class Ic, and class III drugs on the inducibility of DWR.In 11 Langendorff-perfused rabbit hearts, a thin ring of anisotropic left ventricular epicardium was created by a cryoprocedure. VT with a revolution time of 180 +/- 26 milliseconds and an EG of 106 +/- 8 milliseconds was induced by incremental pacing. During control, entrainment with 10 stimuli at a 99 +/- 15-millisecond interval terminated VT in seven hearts. In four hearts VT was accelerated from 205 +/- 24 to 115 +/- 14 milliseconds by introduction of a second circulating wave in the ring. In the seven VTs that could not be accelerated, 0.5 mumol/L Org7797 (class Ic) and 1.0 mmol/L heptanol (uncoupling agent) prolonged the cycle length of VT by 32% and 37%, respectively. Because the refractory period (RP) only increased by 11%, the EG prolonged by 71% and the ratio between EG and RP was increased from 0.66 to 1.00. Under these conditions, DWR could be induced in all seven hearts. In the four VTs that could be accelerated during control, administration of the class III drug D-sotalol (35 mumol/L) only slightly slowed VT by 6%. Because the RP was prolonged by 15%, the ratio between the EG and the RP decreased from 0.76 to 0.63. Entrainment now failed to accelerate VT in two of four hearts, whereas in the two other hearts, double-wave reentry self-terminated within eight cycles.Drugs that increase the ratio of EG and RP enhance the susceptibility to acceleration of VT, whereas drugs that decrease this ratio prevent induction of sustained double-wave reentry.
Unearthing uric acid: An ancient factor with recently found significance in renal and cardiovascular disease
Authors: T. Nakagawa, D.H. Kang, D. Feig, L.G. Sanchez-Lozada, T.R. Srinivas, Y. Sautin, A.A. Ejaz, M. Segal, R.J. Johnson
Journal: Kidney International (2006)
Effect of hormone replacement therapy on cardiovascular events in recently postmenopausal women: randomised trial
Authors: L. L. Schierbeck, L. Rejnmark, C. L. Tofteng, L. Stilgren, P. Eiken, L. Mosekilde, L. Kober, J.-E. B. Jensen
Journal: BMJ (2012)

<b>Objective</b> To investigate the long term effect of hormone replacement therapy on cardiovascular outcomes in recently postmenopausal women. <b>Design</b> Open label, randomised controlled trial. <b>Setting</b> Denmark, 1990-93. <b>Participants</b> 1006 healthy women aged 45-58 who were recently postmenopausal or had perimenopausal symptoms in combination with recorded postmenopausal serum follicle stimulating hormone values. 502 women were randomly allocated to receive hormone replacement therapy and 504 to receive no treatment (control). Women who had undergone hysterectomy were included if they were aged 45-52 and had recorded values for postmenopausal serum follicle stimulating hormone. <b>Interventions</b> In the treatment group, women with an intact uterus were treated with triphasic estradiol and norethisterone acetate and women who had undergone hysterectomy received 2 mg estradiol a day. Intervention was stopped after about 11 years owing to adverse reports from other trials, but participants were followed for death, cardiovascular disease, and cancer for up to 16 years. Sensitivity analyses were carried out on women who took more than 80% of the prescribed treatment for five years. <b>Main outcome measure</b> The primary endpoint was a composite of death, admission to hospital for heart failure, and myocardial infarction. <b>Results</b> At inclusion the women on average were aged 50 and had been postmenopausal for seven months. After 10 years of intervention, 16 women in the treatment group experienced the primary composite endpoint compared with 33 in the control group (hazard ratio 0.48, 95% confidence interval 0.26 to 0.87; P=0.015) and 15 died compared with 26 (0.57, 0.30 to 1.08; P=0.084). The reduction in cardiovascular events was not associated with an increase in any cancer (36 in treated group <i>v</i> 39 in control group, 0.92, 0.58 to 1.45; P=0.71) or in breast cancer (10 in treated group <i>v</i> 17 in control group, 0.58, 0.27 to 1.27; P=0.17). The hazard ratio for deep vein thrombosis (2 in treated group <i>v</i> 1 in control group) was 2.01 (0.18 to 22.16) and for stroke (11 in treated group <i>v</i> 14 in control group) was 0.77 (0.35 to 1.70). After 16 years the reduction in the primary composite outcome was still present and not associated with an increase in any cancer. <b>Conclusions</b> After 10 years of randomised treatment, women receiving hormone replacement therapy early after menopause had a significantly reduced risk of mortality, heart failure, or myocardial infarction, without any apparent increase in risk of cancer, venous thromboembolism, or stroke. <b>Trial registration</b> ClinicalTrials.gov NCT00252408.
The effect of bioartificial constructs that mimic myocardial structure and biomechanical properties on stem cell commitment towards cardiac lineage
Authors: Caterina Cristallini, Elisa Cibrario Rocchietti, Lisa Accomasso, Anna Folino, Clara Gallina, Luisa Muratori, Pasquale Pagliaro, Raffaella Rastaldo, Stefania Raimondo, Silvia Saviozzi, Andrea E. Sprio, Mariacristina Gagliardi, Niccoletta Barbani, Claudia Giachino
Journal: Biomaterials (2013)
A phase 1/2 study of an adjuvanted varicella-zoster virus subunit vaccine in autologous hematopoietic cell transplant recipients
Authors: Edward A. Stadtmauer, Keith M. Sullivan, Francisco M. Marty, Sanjeet S. Dadwal, Genovefa A. Papanicolaou, Thomas C. Shea, Sherif B. Mossad, Charalambos Andreadis, Jo-Anne H. Young, Francis K. Buadi, Mohamed El Idrissi, Thomas C. Heineman, Elchonon M. Berkowitz
Journal: Blood (2014)
Transvaginal rigid-hybrid NOTES cholecystectomy: evaluation in routine clinical practice
Authors: G. Linke, I. Tarantino, R. Hoetzel, R. Warschkow, J. Lange, R. Lachat, A. Zerz
Journal: Endoscopy (2010)

Background and study aims: Cholecystectomy using a rigid-hybrid transvaginal natural orifice transluminal endoscopic surgery (NOTES) approach (tvNCC) reduces abdominal wall incisions and might decrease surgical trauma by combining endoluminal access and laparoscopic techniques. We assessed the feasibility and safety of rigid-hybrid tvNCC in routine practice for symptomatic cholecystolithiasis or acute cholecystitis in a patient population with low selection.
Cholesterol efflux potential of sera from mice expressing human cholesteryl ester transfer protein and/or human apolipoprotein AI.
Authors: V Atger, M de la Llera Moya, M Bamberger, O Francone, P Cosgrove, A Tall, A Walsh, N Moatti, G Rothblat
Journal: Journal of Clinical Investigation (1995)

The ability of whole serum to promote cell cholesterol efflux and the relationships between apoprotein and lipoprotein components of human serum efflux have been investigated previously (de la Llera Moya, M., V. Atger, J.L. Paul, N. Fournier, N. Moatti, P. Giral, K.E. Friday, and G.H. Rothblat. 1994. Arterioscler. Thromb. 14:1056-1065). We have now used this experimental system to study the selective effects of two human lipoprotein-related proteins, apoprotein AI (apo AI) and cholesteryl ester transfer protein (CETP) on cell cholesterol efflux, when these proteins are expressed in transgenic mice. The percent efflux values for cholesterol released in 4 h from Fu5AH donor cells to 5% sera from the different groups of mice were in the order: background = human apo AI transgenic (HuAITg) > human CETP transgenic (HuCETPTg) > human apo AI and CETP transgenic (HuAICETPTg) >> apo AI knockout mice. In each group of mice a strong, positive correlation (r2 ranging from 0.64 to 0.76) was found between efflux and HDL cholesterol concentrations. The slopes of these regression lines differed between groups of mice, indicating that the cholesterol acceptor efficiencies of the sera differed among groups. These differences in relative efficiencies can explain why cholesterol efflux was not proportional to the different HDL levels in the various groups of mice. We can conclude that: (a) HDL particles from HuAITg mice are less efficient as cholesterol acceptors than HDL from the background mice; (b) despite a lower average efflux due to lower HDL cholesterol concentrations, HDL particles are more efficient in the HuCETPTg mice than in the background mice; and (c) the coexpression of both human apo AI and CETP improves the efficiency of HDL particles in the HuAICETPTg mice when compared with the HuAITg mice. We also demonstrated that the esterification of the free cholesterol released from the cells by lecithin cholesterol acyltransferase in the serum was reduced in the HuAITg and AI knockout mice, whereas it was not different from background values in the two groups of mice expressing human CETP.
Hypersensitivity to Inhaled Flour Allergens Comparison between Cereals
Authors: B. A. Baldo, S. Krilis, C. W. Wrigley
Journal: Allergy (1980)

Radioallergosorbent testing (RAST) of sera from subjects sensitized to wheat and rye Hour indicated that there is significant reaction with seed extracts of 12 cereals (wheat, durum wheat, triticale, cereal rye, barley, rye grass, oats, canary grass, rice, maize, sorghum and Johnson grass). Results were evaluated in terms of taxonomic relationships and of the electrophoretically determined protein composition of the cereal extracts. RAST uptakes were uniformly low in sera from four rhinitic bakers, yet were significantly above the levels for non‐allergic and cord sera. Much higher RAST uptakes were obtained with sera from four asthmatic bakers when tested with wheat and its close relatives, but there was still reasonably high reactivity with more distantly related cereals. RAST inhibition experiments indicated in a more direct way the extent of cross‐reactivity between grain extracts of wheat, rye, barley and oats. One baker had a history of more severe attacks of breathlessness following inhalation of rye flour compared with wheat Hour. This was confirmed by bronchial challenge testing, but the comparison was not obviously consistent with the results of prick testing or estimation of histamine released from his leucocytes. The results as a whole suggested that the bran layers of cereal grains are at least as allergenic as flour.