tbuckley/cabot-search huggingface dataset:
TCTAP A-194 Clinical Outcomes of Bare Metal Stents in Patients with Acute Coronary Syndrome in Rural Health Center- A Single Center Follow up
Authors: Ravi Cherian Mathew, Balasubramaniyan Amirtha Ganesh, Palamalai Arun Prasath, Ashwin Lysander
Journal: Journal of the American College of Cardiology (2014)
The Last Alcoholic Days of F. Scott Fitzgerald
Authors: Howard Markel
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nail scabies as an initial lesion of ordinary scabies
Authors: R. Isogai, A. Kawada, Y. Aragane, T. Tezuka
Journal: British Journal of Dermatology (2002)

Journal Article Nail scabies as an initial lesion of ordinary scabies Get access R. Isogai, R. Isogai Department of Dermatology, Kinki University School of Medicine, Ohno‐Higashi 377–2, Osaka‐Sayama, Osaka 589–8511, Japan Search for other works by this author on: Oxford Academic Google Scholar A. Kawada, A. Kawada Department of Dermatology, Kinki University School of Medicine, Ohno‐Higashi 377–2, Osaka‐Sayama, Osaka 589–8511, Japan Akira Kawada. E‐mail: kawada@med.kindai.ac.jp Search for other works by this author on: Oxford Academic Google Scholar Y. Aragane, Y. Aragane Department of Dermatology, Kinki University School of Medicine, Ohno‐Higashi 377–2, Osaka‐Sayama, Osaka 589–8511, Japan Search for other works by this author on: Oxford Academic Google Scholar T. Tezuka T. Tezuka Department of Dermatology, Kinki University School of Medicine, Ohno‐Higashi 377–2, Osaka‐Sayama, Osaka 589–8511, Japan Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 147, Issue 3, 1 September 2002, Page 603, https://doi.org/10.1046/j.1365-2133.2002.04771.x Published: 01 September 2002
Lymphocyte Sensitization to Carcinoembryonic Antigen (Gold) With Special Reference to Multiple Sclerosis
Authors: E. J. Field, E. A. Caspary
Journal: BMJ (1972)

Lymphocytes from patients with multiple sclerosis are sensitized to carcinoembryonic antigen (C.E.A.) in almost the same degree as are those from subjects with cancer. During pregnancy and the early puerperium there is an even higher degree of cellular sensitization to C.E.A. Patients with neurological diseases other than multiple sclerosis also show significant sensitization to C.E.A. though of less degree than do those with multiple sclerosis. Sensitization to C.E.A. is thus not specifically characteristic of cancer. The unexpected sensitization in multiple sclerosis may be associated with the pronounced degree of gliosis found in that condition.
Suppression of <i>CHK1</i> by ETS Family Members Promotes DNA Damage Response Bypass and Tumorigenesis
Authors: Andrea Lunardi, Shohreh Varmeh, Ming Chen, Riccardo Taulli, Jlenia Guarnerio, Ugo Ala, Nina Seitzer, Tomoki Ishikawa, Brett S. Carver, Robin M. Hobbs, Valentina Quarantotti, Christopher Ng, Alice H. Berger, Caterina Nardella, Laura Poliseno, Rodolfo Montironi, Mireia Castillo-Martin, Carlos Cordon-Cardo, Sabina Signoretti, Pier Paolo Pandolfi
Journal: Cancer Discovery (2015)

The ETS family of transcription factors has been repeatedly implicated in tumorigenesis. In prostate cancer, ETS family members, such as ERG, ETV1, ETV4, and ETV5, are frequently overexpressed due to chromosomal translocations, but the molecular mechanisms by which they promote prostate tumorigenesis remain largely undefined. Here, we show that ETS family members, such as ERG and ETV1, directly repress the expression of the checkpoint kinase 1 (CHK1), a key DNA damage response cell-cycle regulator essential for the maintenance of genome integrity. Critically, we find that ERG expression correlates with CHK1 downregulation in human patients and demonstrate that Chk1 heterozygosity promotes the progression of high-grade prostatic intraepithelial neoplasia into prostatic invasive carcinoma in Pten(+) (/-) mice. Importantly, CHK1 downregulation sensitizes prostate tumor cells to etoposide but not to docetaxel treatment. Thus, we identify CHK1 as a key functional target of the ETS proto-oncogenic family with important therapeutic implications.Genetic translocation and aberrant expression of ETS family members is a common event in different types of human tumors. Here, we show that through the transcriptional repression of CHK1, ETS factors may favor DNA damage accumulation and consequent genetic instability in proliferating cells. Importantly, our findings provide a rationale for testing DNA replication inhibitor agents in ETS-positive TP53-proficient tumors.
STUDIES ON SOUTH AMERICAN YELLOW FEVER
Authors: Nelson C. Davis, Raymond C. Shannon
Journal: The Journal of Experimental Medicine (1929)

Yellow fever virus from M. rhesus has been inoculated into a South American monkey (Cebus macrocephalus) by blood injection and by bites of infected mosquitoes. The Cebus does not develop the clinical or pathological signs of yellow fever. Nevertheless, the virus persists in the Cebus for a time as shown by the typical symptoms and lesions which develop when the susceptible M. rhesus is inoculated from a Cebus by direct transfer of blood or by mosquito (A. aegypti) transmission.
Neutrophils contribute to inflammatory lymphangiogenesis by increasing VEGF-A bioavailability and secreting VEGF-D
Authors: Kar Wai Tan, Shu Zhen Chong, Fiona H. S. Wong, Maximilien Evrard, Sandra Min-Li Tan, Jo Keeble, D. M. Kemeny, Lai Guan Ng, Jean-Pierre Abastado, Véronique Angeli
Journal: Blood (2013)
DENGUE FEVER IN LOUISIANA
Authors: L. C. SCOTT
Journal: JAMA (1923)

The epidemic of dengue fever that prevailed in Louisiana from the early part of September until the latter part of December, 1922, was doubtless introduced into the state from Texas. Reports indicate that Galveston and Houston had been suffering from this disease for some time, and the case dissemination followed closely the course of the Southern Pacific Railroad, the main line of communication between the two states. Shortly after the invasion of southern Louisiana, the epidemic spread diagonally northwest, toward Shreveport, closely approximating the Texas and Pacific line. Subsequent invasion of other cities to the right and left of both railway systems followed in due course. It is quite impossible to know accurately the actual number of cases that occurred; the official reports so far received show less than 8,000. A survey made during the early part of the epidemic indicated that only a fraction of the cases that occurred
An even stronger case for the cognitive impenetrability of visual perception
Authors: Lester E. Krueger
Journal: Behavioral and Brain Sciences (1999)

Pylyshyn could have strengthened his case by avoiding side issues and by taking a sterner, firmer line on the unresolved (and perhaps unresolvable) problems plaguing the sensitivity (d') measure of top-down, cognitive effects, as well as the general (nearly utter!) lack of convincing evidence provided by proponents of the cognitive penetrability of visual perception.
More than Maintenance? A Role for IFT Genes in Planar Cell Polarity
Authors: Kimberly M. Jaffe, Rebecca D. Burdine
Journal: Journal of the American Society of Nephrology (2010)

Once thought to be vestigial organelles, cilia are now recognized as important signaling and sensory centers within some cells.1–3 The process of intraflagellar transport (IFT) controls cilia formation and the targeting of proteins within the cilium. IFT depends on three key components: ( 1 ) An anterograde complex that traffics from the base of the cilium to the tip and consists of the kinesin 2 motor and the IFTB protein complex; ( 2 ) the retrograde complex that brings cargo from the ciliary tip to the base and consists of the cytoplasmic dynein motor and the IFTA protein complex; and ( 3 ) IFTA and B complexes that associate with motors are thought to act as docking sites for IFT cargo.4

In most organisms, loss of the IFTB complex blocks formation of cilia. In zebrafish, however, zygotic mutants in B complex members IFT57, IFT88, and IFT172 still assemble cilia, which degenerate over time, suggesting these IFT proteins are not required for cilia formation. This has led one group to propose that IFT in zebrafish is not required to assemble cilia but rather acts to maintain cilia once they assemble.5

In this issue of JASN , Cao et al. 6 more carefully examine the maternal deposition of IFT57 and IFT72 at the mRNA and protein level. The authors show these proteins …
Changes in glomerular filtration rate following myocardial infarction
Authors: M. C. EFENDIGIL, A. HARLEY, T. DEEGAN, C. S. MCKENDRICK
Journal: Cardiovascular Research (1975)

51Cr EDTA clearance was measured in 10 patients immediately after uncomplicated myocardial infarction and 3 weeks later. The initial values (120 ± 36 ml/min) were significantly higher than the later values (79 ± 23 ml/min). Possible reasons for this are reviewed.
Exercise Acutely Increases Renal Transit Time of Tc-99m Mercaptoacetyltriglycine (MAG3) in a Post-liver Transplant Patient
Authors: Rajan Murthy, Manisha Chahal, Gerald Appel, Steven Bergmann, Ronald Tikofsky, Rashid Fawwaz, Ronald Van Heertum
Journal: Clinical Nuclear Medicine (2006)

This case demonstrates the effect of exercise on the clearance of Tc-99m MAG3 in a patient with renal insufficiency status post-liver transplant. Even after furosemide administration, the tracer was retained in the kidneys after exercise. This is in contrast to normal clearance demonstrated on a baseline study performed 3 days previously.
Abstract 2864: Regulation and targeting of Fyn in cutaneous squamous cell carcinoma
Authors: Sarah Fenton, Mitchell F. Denning
Journal: Cancer Research (2012)

Abstract Over 700,000 cases of cutaneous squamous cell carcinoma (cSCC) occur in the United States every year. Despite this high rate of diagnosis no therapies currently exist that target the molecular mechanism of tumorigenesis. Between 20 and 60% of these tumors contain mutated Ras; however targeting Ras with therapeutics has been unsuccessful in clinical trials. Expression of active H-Ras (G12V) in HaCaT cells (immortalized, non-transformed keratinocytes) results in upregulated expression of Fyn, a Src family kinase that is active in many malignancies and is involved in the elevated invasion/migration of Ras-transformed HaCaT cells. The specific objectives of this project include exploring the mechanism through which Ras activation increases Fyn levels and determining how high levels of Fyn promote cancer cell migration and survival. Using RT-qPCR we verified that Fyn expression is selectively elevated in cells with increased Ras activity, but levels of other Src family kinases (eg Src, Lyn, Yes, Blk, Lck) are not altered. To explore the transcriptional regulation of Fyn in Ras-transformed HaCaT cells we subcloned segments (−2 kb to −50 bp) of the human Fyn promoter in front of firefly luciferase and transfected the reporter constructs into HaCaT and HaCaT-Ras cells (transformed by constitutively active H-Ras). We identified a region −100 to −50 base pairs upstream of the transcription start site that is necessary for Fyn upregulation in HaCaT-Ras cells. The −80 to −65 region of the Fyn promoter contains putative GATA-1, GATA-2, GATA-3, CP2 or TATA transcription factor binding sites. We have also targeted Fyn in Ras-transformed cells using the Src family kinase inhibitor Dasatinib. Already used to treat chronic myelogenous leukemia and Philadelphia chromosome positive acute lymphoblastic leukemia, Dasatinib is also in clinical trials to treat solid tumors. Treatment with varying concentrations of Dasatinib did not reveal greater changes in cell viability, cell cycle progression, apoptosis or autophagy in transformed HaCaT-Ras cells as compared to HaCaT cells. However, upon Dasatinib exposure HaCaT-Ras cells change dramatically in morphology, enhancing cell-cell contacts and reverting from a stellate appearance to the rounded morphology of untransformed HaCaT cells. Due to previous work verifying Fyn's role in promoting the invasion and migration of transformed keratinocytes, we propose that Fyn inhibition in keratinocytes with increased Ras activity will restore cell to cell contacts and provide a potential therapeutic target in the treatment of cSCCs. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2864. doi:1538-7445.AM2012-2864
Pharmacokinetics, interactions with macromolecules and species differences in metabolism of DEHP.
Authors: P W Albro, J T Corbett, J L Schroeder, S Jordan, H B Matthews
Journal: Environmental Health Perspectives (1982)

The recent long-term carcinogenesis bioassay of di(2-ethylhexyl) phthalate (DEHP) in rats and mice reported by the National Toxicology Program was the first such bioassay to implicate DEHP as a hepatocarcinogen. At the levels of DEHP fed (up to 1.2% of the diet for two years), the livers of the rats would have been exposed to unhydrolyzed diester; this would not have been the case at lower dosages. Extrapolation to lower dosages is therefore questionable. We do not have sufficient pharmacokinetic data in mice to evaluate the dose relationships as yet. Rodents differ conspicuously from primates in their manner of metabolizing DEHP, both in terms of the demand made on the oxidation potential of the liver and in the chemical properties of the major metabolites. The relevance of these differences must be determined before rodent species can be considered models for the effects of DEHP in humans. Radioactivity from carbonyl-labeled DEHP did not associate with purified protein, RNA or DNA from rat liver in vivo. Label from 2-ethyl-(1-14C)-hexyl-labeled DEHP or mono(2-ethylhexyl) phthalate (MEHP) did appear to associate strongly with purified DNA, but label from free 14C-labeled 2-ethylhexanol did not. The apparent binding from DEHP and MEHP was not exchangeable, but was not proven to be covalent. This phenomenon needs additional study.
Aortic endothelial cells regulate proliferation of human monocytes in vitro via a mechanism synergistic with macrophage colony-stimulating factor. Convergence at the cyclin E/p27(Kip1) regulatory checkpoint.
Authors: A S Antonov, D H Munn, F D Kolodgie, R Virmani, R G Gerrity
Journal: Journal of Clinical Investigation (1997)

Monocyte-derived macrophages (Mphis) are pivotal participants in the pathogenesis of atherosclerosis. Evidence from both animal and human plaques indicates that local proliferation may contribute to accumulation of lesion Mphis, and the major Mphi growth factor, macrophage colony stimulating factor (MCSF), is present in atherosclerotic plaques. However, most in vitro studies have failed to demonstrate that human monocytes/Mphis possess significant proliferative capacity. We now report that, although human monocytes cultured in isolation showed only limited MCSF-induced proliferation, monocytes cocultured with aortic endothelial cells at identical MCSF concentrations underwent enhanced (up to 40-fold) and prolonged (21 d) proliferation. In contrast with monocytes in isolation, this was optimal at low seeding densities, required endothelial cell contact, and could not be reproduced by coculture with smooth muscle cells. Intimal Mphi isolated from human aortas likewise showed endothelial cell contact-dependent, MCSF-induced proliferation. Consistent with a two-signal mechanism governing Mphi proliferation, the cell cycle regulatory protein, cyclin E, was rapidly upregulated by endothelial cell contact in an MCSFindependent fashion, but MCSF was required for successful downregulation of the cell cycle inhibitory protein p27(Kip1) before cell cycling. Thus endothelial cells and MCSF differentially and synergistically regulate two Mphi genes critical for progression through the cell cycle.
COMPARATIVE EFFECTIVENESS OF RADIAL ACCESS AND BIVALIRUDIN ON PCI-RELATED BLEEDING EVENTS: ANALYSIS FROM THE NATIONAL CARDIOVASCULAR DATA REGISTRY®
Authors: Steven P. Marso, Amit Amin, John A. House, Kevin F. Kennedy, John A. Spertus, Sunil V. Rao, John C. Messenger, John S. Rumsfeld
Journal: Journal of the American College of Cardiology (2010)
Adult linear IgA bullous dermatosis with bronchial involvement
Authors: F. VERHELST, M. DEMEDTS, J. VERSCHAKELEN, E. VERBEKEN, K. MARIEN, C. PEETERS
Journal: British Journal of Dermatology (1987)

Journal Article Adult linear IgA bullous dermatosis with bronchial involvement Get access F. VERHELST, F. VERHELST Division of Lung Disease, Department of Internal Medicine, University Hospitals, Leuven, Belgium Search for other works by this author on: Oxford Academic Google Scholar M. DEMEDTS, M. DEMEDTS Division of Lung Disease, Department of Internal Medicine, University Hospitals, Leuven, Belgium Professor M. Demedts, Universitair Ziekenhuis, Weligerveld I, 8‐3041 Pellenberg, Leuven, Belgium Search for other works by this author on: Oxford Academic Google Scholar J. VERSCHAKELEN, J. VERSCHAKELEN Department of Radiology, University Hospitals, Leuven, Belgium Search for other works by this author on: Oxford Academic Google Scholar E. VERBEKEN, E. VERBEKEN Department of Histopathology, University Hospitals, Leuven, Belgium Search for other works by this author on: Oxford Academic Google Scholar K. MARIËN, K. MARIËN Department of Dermatology, University Hospitals, Leuven, Belgium Search for other works by this author on: Oxford Academic Google Scholar C. PEETERS C. PEETERS Department of Histopathology, University Hospitals, Leuven, Belgium Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 116, Issue 4, 1 April 1987, Pages 587–590, https://doi.org/10.1111/j.1365-2133.1987.tb05884.x Published: 01 April 1987
Abstract 3232: The proteome analysis of mice lung tumors
Authors: Shotaro Yamano, Anna Kakehashi, Yoshiyuki Tago, Keikou Tei, Min Wei, Hideki Wanibuchi
Journal: Cancer Research (2010)

Abstract We have previously shown that lung squamous cell carcinoma (SCC) is induced by 20 weeks treatment with N-nitroso-tris-chloroethylurea (NTCU) The aim of the present study was to investigate the expression patterns of proteins in lung adenocarcinoma (AdCa) and SCC Seven mice were treated with single i p injection of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK, 2 mg/0 1 ml saline/mouse) on the first experimental day and sacrificed after 55 weeks (AdCa-induced model) Twenty six mice were treated topically with NTCU (0 01 M 75 μl/mouse) twice a week for eighteen weeks and sacrificed after 22 weeks (SCC-induced model) SCC and AdCa samples were collected from each group and proteome analysis was carried out by using QSTAR Elite LC-MS/MS 187 proteins were identified with 95% confidence or higher and quantified with ProteinPilot 2 0 Software Significant overexpression of 52 proteins (e g SP-C, TIM) were detected in lung AdCa compared to normal-appearing tissues and 46 proteins (e g cytokeratins 6A, 5, 19) were detected in SCC Expression patterns of proteins largely differed between AdCa and SCC Furthermore AdCa and SCC are suggested to be derived from type II pneumocytes and clara cell, respectively Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3232.
A CASE OF CELLULITIS: FOLLOWING INFECTION BY AN ORGANISM SET FREE BY THE WOUNDING OF AN OLD BLIND DIVERTICULUM OF THE LARGE INTESTINE
Authors: G. H. Makins
Journal: BMJ (1907)

found in the blood; these in turn are produced by some bodies formed in the gastro intestinal tract.The altered growth of the flora of the stomach and intestine in certain nutrient media, as produced in the Fig. 5.-Completely healed ulcer (stomach of dog).feeding experiments, indicates the important factors in the formation of ulcer of the stomach or duodenum, and the relation to other pathological conditions frequently associated with-the lesions.
Cross-talk between Notch and the Estrogen Receptor in Breast Cancer Suggests Novel Therapeutic Approaches
Authors: Paola Rizzo, Haixi Miao, Gwendolyn D'Souza, Clodia Osipo, Jieun Yun, Huiping Zhao, Joaquina Mascarenhas, Debra Wyatt, Giovanni Antico, Lu Hao, Katharine Yao, Prabha Rajan, Chindo Hicks, Kalliopi Siziopikou, Suzanne Selvaggi, Amina Bashir, Deepali Bhandari, Adriano Marchese, Urban Lendahl, Jian-Zhong Qin, Debra A. Tonetti, Kathy Albain, Brian J. Nickoloff, Lucio Miele
Journal: Cancer Research (2008)

Abstract High expression of Notch-1 and Jagged-1 mRNA correlates with poor prognosis in breast cancer. Elucidating the cross-talk between Notch and other major breast cancer pathways is necessary to determine which patients may benefit from Notch inhibitors, which agents should be combined with them, and which biomarkers indicate Notch activity in vivo. We explored expression of Notch receptors and ligands in clinical specimens, as well as activity, regulation, and effectors of Notch signaling using cell lines and xenografts. Ductal and lobular carcinomas commonly expressed Notch-1, Notch-4, and Jagged-1 at variable levels. However, in breast cancer cell lines, Notch-induced transcriptional activity did not correlate with Notch receptor levels and was highest in estrogen receptor α–negative (ERα−), Her2/Neu nonoverexpressing cells. In ERα+ cells, estradiol inhibited Notch activity and Notch-1IC nuclear levels and affected Notch-1 cellular distribution. Tamoxifen and raloxifene blocked this effect, reactivating Notch. Notch-1 induced Notch-4. Notch-4 expression in clinical specimens correlated with proliferation (Ki67). In MDA-MB231 (ERα−) cells, Notch-1 knockdown or γ-secretase inhibition decreased cyclins A and B1, causing G2 arrest, p53-independent induction of NOXA, and death. In T47D:A18 (ERα+) cells, the same targets were affected, and Notch inhibition potentiated the effects of tamoxifen. In vivo, γ-secretase inhibitor treatment arrested the growth of MDA-MB231 tumors and, in combination with tamoxifen, caused regression of T47D:A18 tumors. Our data indicate that combinations of antiestrogens and Notch inhibitors may be effective in ERα+ breast cancers and that Notch signaling is a potential therapeutic target in ERα− breast cancers. [Cancer Res 2008;68(13):5226–35]