Calcitonin—A Progress Report
Authors: J. L. H. O'RIORDAN
Journal: Annals of Internal Medicine (1969)

Editorial Notes1 October 1969Calcitonin—A Progress ReportJ. L. H. O'RIORDAN, M.R.C.P.J. L. H. O'RIORDAN, M.R.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-71-4-859 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTwo years ago when the subject was reviewed here (1), it was forecast that the structure of porcine calcitonin (or thyrocalcitonin) would soon be known. It was suggested that the structure of human calcitonin might be elucidated by analyses of differences. Surprisingly, these predictions have been surpassed (2). Last year three groups almost simultaneously (3-5) described the amino acid sequence of porcine calcitonin, and shortly after that in two laboratories the complete synthesis of the 32 amino acid peptide was achieved. At the end of last year human calcitonin was isolated, and its sequence was determined (6); it occurs in...References1. O'RIORDAN JL: Thyrocalcitonin. Ann. Intern. Med. 67: 903, 1967. LinkGoogle Scholar2. TAYLOR S (Editor): Calcitonin, 1969. Proceedings of a Symposium held July 21-24, 1969. Heinemann Medical Books Ltd., London, in press. Google Scholar3. BELL PH, BARG WF, COLUCCI DF, DAVIES MC, DZIOBKOWSKI C, ENGLERT ME, HEYDER E, PAUL R, and SNEDEKER EH: Purification and structure of porcine calcitonin 1. J. Amer. Chem. Soc. 90: 2704, 1968. CrossrefMedlineGoogle Scholar4. POTTS JT, NIALL HD, KEUTMANN HT, BREWER HB, and DEFTOS LJ: The amino acid sequence of porcine thyrocalcitonin. Proc. Nat. Acad. Sci. USA 59: 1321, 1968. CrossrefMedlineGoogle Scholar5. NEHER R, RINIKER B, ZUBER H, RITTEL W, and KAHNT FW: Thyrocalcitonin II. Struktur von α-thyrocalcitonin. Helv. Chim. Acta 51: 917, 1968. CrossrefMedlineGoogle Scholar6. NEHER R, RINIKER B, RITTEL W, and ZUBER H: Menschliches Calcitonin III: Struktur von Calcitonin M und D. Ibid., p. 1900. Google Scholar7. CLARK MB, BOYD GW, BYFIELD PG, and FOSTER G: A radio immunoassay for human calcitonin M. Lancet 2: 74, 1969. CrossrefMedlineGoogle Scholar8. COPP DH, BROOKS CE, Low BS, NEWSOME F, O'DOR RK, PARKES CO, and WALKER V: Calcitonin and ultimobranchial function in lower vertebrates, in Calcitonin, 1969. Proceedings of a Symposium held July 21-24, 1969. Heinemann Medical Books Ltd., London, in press. Google Scholar9. WEST TE, O'RIORDAN JL, and CARE AD: The clearance of homologous calcitonin. J. Endocr. In press. Google Scholar10. HAZARD JB, HAWK WA, and CRILE G: Medullary (solid) carcinoma of the thyroid—a clinicopathologic entity. J. Clin. Endocr. 19: 152, 1959. CrossrefMedlineGoogle Scholar11. CUNLIFFE WJ, BLACK MM, HALL R, JOHNSTON ID, HUDGSON P, SHUSTER S, GUDMUNDSSON TV, JOPLIN GF, WILLIAMS ED, WOODHOUSE NJ, GALANTE L, and MACINTYRE I: A calcitonin-secreting thyroid carcinoma. Lancet 2: 63, 1968. CrossrefGoogle Scholar12. WILLIAMS ED: Medullary carcinoma of the thyroid, in Calcitonin, 1969. Proceedings of a Symposium held July 21-24, 1969. Heinemann Medical Books Ltd., London, in press. CrossrefGoogle Scholar13. POTTS JT, PARSONS JA, NEER RM, KRANE SM, DEFTOS LJ, and SHIELDS CL: Pharmacology of calcitonin: human and animal studies. Ibid. Google Scholar14. WEST TE and O'RIORDAN JL: The effects of porcine calcitonin in hypercalcaemia. In preparation. Google Scholar15. MILHAUD G, MOUKHTAR MS, PERAULT-STAUB AM, ARDAILLOU R, BLOCH-MICHEL H, COUTRIS G, GAREL JM, JOB JC, KLINGER E, LAMBERTZ JM, SIZONENKO P, and TUBIANA M: Thyrocalcitonin in man, in Calcitonin, 1969. Proceedings of a Symposium held July 21-24, 1969. Heinemann Medical Books Ltd., London, in press. Google Scholar16. HIOCO D, BORDIER P, MIRAVET L, DENYS H, and TUN-CHOT S: Effect of calcitonin in man: biological, isotopic and morphologic studies. Ibid. Google Scholar17. BIJVOET O, VAN DER SLUYS VEER J, WILDIERS J, and SMEENK D: Effects of long term calcitonin administration to patients. Ibid. Google Scholar18. MACINTYRE I: Human calcitonin: practical and theoretical consequences. Ibid. Google Scholar19. PEACOCK M and NORDIN BE: The role of the kidney in serum calcium homeostasis. Ibid. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: J. L. H. O'RIORDAN, M.R.C.P.Affiliations: The Middlesex Hospital London W.1 England PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1969Volume 71, Issue 4Page: 859-860KeywordsAmino acidsCalcitonin ePublished: 1 December 2008 Issue Published: 1 October 1969 PDF downloadLoading ...