Autoantibodies to Nuclear Lamins
Authors: ENG M. TAN
Journal: Annals of Internal Medicine (1988)

Editorials1 June 1988Autoantibodies to Nuclear LaminsENG M. TAN, M.D.ENG M. TAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-108-6-897 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn this issue, Lassoued and colleagues (1) describe findings related to the presence of autoantibodies to lamin proteins B, A, and C in a heterogeneous group of patients with thrombocytopenia, neutropenia, and liver disease. Autoantibodies to lamin proteins have previously been described by McKeon and colleagues (2), Reeves and colleagues (3) and in an unpublished paper (Wesierska-Gadek, J, et al. Antibodies to nuclear lamins in autoimmune liver diseases). The present authors and others have described the characteristics of the immunologic reaction that comprises autoantibodies detectable by Western blotting of lamin B (a protein of 68 kilodaltons) and of lamins A...References1. LASSOUED K, GUILLY M, and DANON F. Antinuclear antibodies specific for lamins: characterization and clinical significance. Ann Intern Med. 1988;108:829-833. LinkGoogle Scholar2. MCKEON F, TUFFANELLI D, FUKUYAMA K, and KIRSCHNER M. Autoimmune response directed against conserved determinants of nuclear envelope proteins in a patient with linear scleroderma. Proc Natl Acad Sci USA. 1983;80:4374-8. CrossrefMedlineGoogle Scholar3. REEVES W, CHAUDHARY N, SALERNO A, and BLOBEL G. Lamin B autoantibodies in sera of certain patients with systemic lupus erythematosus. J Exp Med. 1987;165:750-62. CrossrefMedlineGoogle Scholar4. GERACE L. Nuclear lamina and organization of nuclear architecture. Trends in Biochem. Science. 1986;11:443-6. CrossrefGoogle Scholar5. FRANKE W. Nuclear lamins and cytoplasmic intermediate filament proteins: a growing multigene family. Cell. 1987;48:3-4. CrossrefMedlineGoogle Scholar6. TAN E, CHAN E, SULLIVAN K, and RUBIN R. Antinuclear antibodies (ANAs): diagnostically specific immune markers and clues towards the understanding of systemic autoimmunity. Clin Immunol Immunopathol. 1988;[In press]. CrossrefMedlineGoogle Scholar7. BUNN C, BERNSTEIN R, and MATHEWS M. Autoantibodies against alanyl-tRNA synthetase and tRNA Ala co-exist and are associated with myositis. J Exp Med. 1986; 163:1281-91. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ENG M. TAN, M.D.Affiliations: Scripps Clinic and Research Foundation La Jolla, California PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDr Eng M. Tan: a tribute to an enduring legacy in autoimmunityLamin B1 duplications cause autosomal dominant leukodystrophyClinical associations of anti-lamin autoantibodiesClinical manifestations in patients with autoantibodies specific for nuclear lamin proteinsDiversity and origin of rheumatologic autoantibodiesAutoantibodies to DNA, lamins, and pore complex proteins produce distinct peripheral fluorescent antinuclear antibody patterns on the Hep-2 substrateAutoantibodies to Lamins A and C in Sera of Patients Showing Peripheral Fluorescent Antinuclear Antibody Pattern on HEP-2 CellsIn Vitro Posttranslational Modification of Lamin B Cloned from a Human T-Cell LineAntinuclear Antibodies: Diagnostic Markers for Autoimmune Diseases and Probes for Cell Biology 1 June 1988Volume 108, Issue 6Page: 897-898KeywordsAntibodiesAutoantibodiesAutoimmune diseasesLiver diseasesNeutropeniaProteinsWestern blot ePublished: 1 December 2008 Issue Published: 1 June 1988 PDF downloadLoading ...