Benzidine-positive Pigments in Serum of Patients with Sickle Cell Anemia During Painful Crises
Authors: IWAO IUCHI
Journal: Annals of Internal Medicine (1964)

Article1 June 1964Benzidine-positive Pigments in Serum of Patients with Sickle Cell Anemia During Painful CrisesIWAO IUCHI, PH.D., L. W. DIGGS, M.D., J. D. UPSHAW JR., M.D.IWAO IUCHI, PH.D.Search for more papers by this author, L. W. DIGGS, M.D.Search for more papers by this author, J. D. UPSHAW JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-6-1022 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPrevious studies have shown that there is no evidence of a significant increase in the rate of hemolysis of red cells in patients with sickle cell anemia at the time of their painful crisis as compared with the steady state and as revealed by erythrocyte values, reticulocytes and nucleated red cells in circulating blood, and by bile pigments in plasma, urine, and feces (1). Further evidence supporting the thesis that hemolysis is not a major component in the recurrent episodes of pain and fever is furnished by studies of the concentration of benzidine-positive pigments in the plasma. It is the...References1. DIGGS LW: The crisis in sickle cell anemia: hematologic studies. Amer. J. Clin. Path. 26: 1109, 1956. CrossrefMedlineGoogle Scholar2. CROSBYFURTH WHFW: A modification of the benzidine method for measurement of hemoglobin in plasma and urine. Blood 11: 380, 1956. CrossrefMedlineGoogle Scholar3. CROSBYDAMESHEK WHW: The significance of hemoglobinemia and associated hemosiderinuria, with particular reference to various types of hemolytic anemia. J. Lab. Clin. Med. 38: 829, 1951. MedlineGoogle Scholar4. KEITELBLAKELY HGJ: The plasma hemoglobin concentration in sickle cell disease. Amer. J. Dis. Child. 29: 511, 1956. Google Scholar5. HERMAN EC: Serum haptoglobins in hemolytic disorders. J. Lab. Clin. Med. 57: 834, 1961. MedlineGoogle Scholar6. WHITTEN CF: Studies on serum haptoglobin: a functional inquiry. New Eng. J. Med. 266: 529, 1962. CrossrefMedlineGoogle Scholar7. LATHEMJENSON WWN: The renal excretion of hemoglobin in sickle cell anemia, with observations of spontaneously occurring hemoglobinemia and methemalbuminemia. J. Lab. Clin. Med. 59: 137, 1962. MedlineGoogle Scholar8. UPSHAWIUCHIDIGGSLYLE JDILWD: Serum benzidine-positive pigments in sickle cell anemia. J. Lab. Clin. Med. 62: 950, 1963. MedlineGoogle Scholar9. ERLANDSONSCHULMANSMITH MEICH: Studies on congenital hemolytic syndromes. III. Rates of destruction and production of erythrocytes in sickle cell anemia. Pediatrics 25: 629, 1960. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Memphis, TennesseeFrom the Division of Hematology and Laboratory Medicine, University of Tennessee College of Medicine and City of Memphis Hospitals, Memphis, Tennessee.This investigation was supported in part by the ALSAC-St. Jude research grant and in part by grant H-7275, National Heart Institute, National Institutes of Health, United States Public Health Service, Bethesda, Maryland.Dr. Iwao Iuchi is a Fellow in Hematology, University of Tennessee College of Medicine, Memphis, Tennessee.Requests for reprints should be addressed to L. W. Diggs, M.D., 42 N. Dunlap Street, Memphis 3, Tennessee. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByVariation in serum electrolytes and enzyme concentrations in patients with sickle cell disease. 1 June 1964Volume 60, Issue 6Page: 1022-1027KeywordsAnemiaAttentionBlood cellsBlood plasmaHematology and oncologyHemoglobinPlasma cellsResearch laboratoriesReticulocytesUrine Issue Published: 1 June 1964 PDF DownloadLoading ...