tbuckley/cabot-search huggingface dataset:
ERK1/2 antagonize AMPK-dependent regulation of FcεRI-mediated mast cell activation and anaphylaxis
Authors: Seung-Lark Hwang, Yue Lu, Xian Li, Yong Deuk Kim, You Sook Cho, Yurndong Jahng, Jong-Keun Son, Youn Ju Lee, Wonku Kang, Yoshitaka Taketomi, Makoto Murakami, Tae Chul Moon, Hyeun Wook Chang
Journal: Journal of Allergy and Clinical Immunology (2014)
HLA antigens in systemic lupus erythematosus.
Authors: C Dostal, D Ivanyi, H Macurova, I Hana, J Strejcek
Journal: Annals of the Rheumatic Diseases (1977)

Forty-five patients suffering from systemic lupus erythematosus were studied in respect of their serologically defined HLA antigens. HLA-B8 antigen was found in 37-8% of patients as compared to 22% of controls. Individuals carrying the HLA-B8 antigen have a 2-15 times greater risk of developing systemic lupus erythematosus than those not carrying this antigen.
Aspects of Type 2 Diabetes and Related Insulin-Resistant States
Authors: Zachary T. Bloomgarden
Journal: Diabetes Care (2006)

This is the fourth in a series of articles on presentations at the American Diabetes Association Annual Meeting, San Diego, California, 10–14 June 2005.

Addressing the debate over aerobic versus anaerobic exercise, Sigal et al. (abstract 371) reported results of the Diabetes Aerobic and Resistance Exercise (DARE) clinical trial of 251 previously inactive persons with type 2 diabetes exercising at local YMCAs, supervised by personal trainers. Both aerobic and resistance training improved HbA1c (A1C) similarly over 6months, with the combination of both forms of exercise improving A1C more than either type alone. Goh et al. (abstract 1089) reported a similar study from Singapore comparing 22 persons with type 2 diabetes randomized to either aerobic exercise, with a 10/10-mmHg decrease in blood pressure and a 0.3% decrease in A1C, or resistance training, with a 0.6% decrease in A1C. Morrato et al. (abstracts 1041 and 1063), analyzing the national Medical Expenditure Panel Survey (2000–2002) found that 55% of 97,422 adults ≥18 years of age, but 39% of those with self-reported diabetes, stated they participated in moderate/vigorous activity for at least 30 min at least three times weekly. Among those with BMI <25, 25–29.9, 30–39.9, and ≥40 kg/m2, the likelihood of diabetes was 52, 59, 41, and 13% greater in inactive than in active persons, respectively, adjusting for age, sex, education level, race, ethnicity, and cigarette smoking.

Gaillard et al. (abstract 1086) reported a study of 46 African-American women without diabetes, showing that those with moderately good aerobic fitness had lower weight and blood pressure and higher insulin sensitivity than those with low or very low levels of fitness. Similarly, Snitker et al. (abstract 1094) found that among 80 Amish persons, who habitually engage in physical exercise, the time spent in moderate to vigorous activity correlated directly with the degree …
Impaired glucose tolerance, type 2 diabetes, and carotid wall thickness: the Insulin Resistance Atherosclerosis Study.
Authors: L E Wagenknecht, R B D'Agostino, S M Haffner, P J Savage, M Rewers
Journal: Diabetes Care (1998)

OBJECTIVE: To assess whether people with impaired glucose tolerance (IGT) exhibit an increased risk of atherosclerosis as measured by the thickness of the carotid artery. RESEARCH DESIGN AND METHODS: We examined the relationship between glucose tolerance status and subclinical atherosclerosis in the Insulin Resistance Atherosclerosis Study (IRAS). The IRAS is an epidemiological study of 1,625 Hispanic, African-American, and white men and women, with approximately equal numbers of subjects with normal glucose tolerance (NGT), IGT, and type 2 diabetes as assessed by an oral glucose tolerance test. Half of those with diabetes were previously unaware of their condition and were defined as having new diabetes. Persons using insulin were excluded. The intima-media thickness (IMT) of the common carotid artery (CCA) and internal carotid artery (ICA) was measured as an index of subclinical atherosclerosis using B-mode ultrasonography. RESULTS: Adjusted for demographics and smoking, CCA-IMT increased most notably at the level of established diabetes (802, 822, 831, and 896 microm for NGT, IGT, new diabetes, and established diabetes, respectively). Adjustment for coronary heart disease (CHD) risk factors, which tended to worsen across glucose tolerance category, further minimized the slightly graded relationship. The relationship with the ICA-IMT was steeper and again suggested that the increased wall thickness is associated with diabetes, not with IGT. The relationship between glucose tolerance category and IMT was similar in men and women. CONCLUSIONS: We observed considerably greater IMT among persons with established diabetes but no significant increase in persons with IGT. These data suggest that the increased risk of CHD observed in persons with diabetes may largely develop after the onset of overt diabetes.
Down-regulation of Langerhans cell protein kinase C-β isoenzyme expression in inflammatory and hyperplastic dermatoses
Authors: N.J. REYNOLDS, J.Y. YI, G.J. FISHER, K.D. COOPER, J.J. VOORHEES, C.E.M. GRIFFITHS
Journal: British Journal of Dermatology (1995)

The family of protein kinase C (PKC) isoenzymes plays a fundamental part in signal transduction, and thereby regulates important cellular functions, including growth, differentiation, cytokine production and adhesion molecule expression. In lesional psoriatic skin. Ca2+-dependent PKC activity, PKC-β protein and epidermal Langerhans cell (LC) PKC-β immunostaining are significantly decreased, indicating activation and subsequent down-regulation of PKC. Whether these changes occur in other inflammatory/hyperplastic dermatoses is, however, unknown. We examined PKC-α and PKC-β expression in normal skin, psoriasis, cutaneous T-cell lymphoma (CTCL), lamellar ichthyosis, non-bullous ichthyosiform erythroderma, atopic dermatitis, urushiol-induced allergic contact dermatitis, and sodium lauryl sulphate (SLS)-induced irritant contact dermatitis. Cryostat sections were stained for PKC-α and PKC-β, and the LC marker CDla, using an immunoperoxidase technique and specific monoclonal antibodies. Double-labelling studies, in normal skin, revealed co-expression of PKC-β and CDla by epidermal LCs. Analysis of the number of PKC-β+ and CDla+ epidermal LCs, in diseased compared with normal skin, revealed three categories: (i) in psoriasis and CTCL. the PKC-β+ epidermal LC number was significantly reduced, whereas the CDla+ epidermal LC number was unchanged; (ii) in allergic and irritant contact dermatitis, both PKC-β+ and CDla+ epidermal LCs were significantly reduced in number; and (iii) in atopic dermatitis, the PKC-β+ epidermal LC number was normal, and CDla+ epidermal LCs were significantly increased in number. Moreover, the ratio of epidermal LC PKC+/CDla+ was reduced in all the dermatoses studied, suggesting activation of PKC-β, with subsequent down-regulation. Within the dermis, increased PKC-β staining of infiltrating cells was observed in all the conditions studied except lamellar ichthyosis and non-bullous ichthyosiform erythroderma. These data indicate that: (i) down-regulation of LC FKC-β occurs in a variety of inflammatory and hyperplastic skin disorders, and is not unique to psoriasis, and (iii the pattern of epidermal LC PKC-β and CDla expression varies among the diseases studied. In mice, PKC activation induces LC migration. Thus, down-regulation of epidermal LC PKC-β associated with reduced CDla+ epidermal LCs in allergic and irritant contact dermatitis suggests that PK.C-β may transduce the signal for migration of LCs from human epidermis.
Possibly Unrecognized Forms of Heart Disease
Authors: HOWARD B. BURCHELL
Journal: Circulation (1963)

THE TITLE of this presentation might imply that many forms of heart disease were possibly escaping recognition.Perhaps a more hackneyed title, such as "Pitfalls in Diagnosis, "Missed Diagnoses," or "IRefleetions on Cardiac Diagnosis," would be more appropriate.At the end of the month or semester, one may reflect on his practice and figuratively calculate his diagnostic batting average; the analysis of his errors, minor or major as they mav be, can be a humbling, yet rewarding task.Obviously, all personally unrecognized, or erroneously labeled, forms of heart disease cannot be evaluated during such reflection.It is necessary to have a final diagnosis, ob- tained either on a subsequent occasion or by a colleague in either a clinical or a pathologic, anatomic setting.General categories of missed diagnloses are:(1) rarities, (2) simulators, (3) complicators, and (4) the emotionally obscured. RaritiesThese may be unknown to the physician or even yet to be described.Each specialist un- doubtedly sees a patient, each week or so, who presents a picture so puzzling that he may wonder if some new syndrome is teasingly waiting to be identified.Are there disease states equivalent in rarity to the carcinoid syndrome, primary aldosteronism, renal ar- tery fibromuscular disease with hypertension, and pheoehromocytoma that are escaping Froimi the Mayo Clinic and the Mayo Foundation, Roclhester, Minnesota.
INTRACELLULAR SURVIVAL OF STAPHYLOCOCCI
Authors: Frank A. Kapral, Mehdi Gh. Shayegani
Journal: The Journal of Experimental Medicine (1959)

A tissue culture procedure is described which permits the quantitative evaluation of the intracellular survival of staphylococci within leucocytes. Staphylococcus aureus survived, but did not multiply, within neutrophils and monocytes of normal rabbits. The same was true of normal human blood leucocytes. Staphylococcus albus on the other hand was destroyed by these cells under the same conditions. Rat monocytes destroyed S. aureus and S. albus with equal facility. Although most experiments were carried out in the presence of 50 µg. streptomycin/ml., similar results were obtained without the use of this antibiotic. The applications of the tissue culture procedure with regard to studies on virulence and immunity in staphylococcal disease are discussed.
Ex-vivo expanded human NK cells mediate cytotoxicity and cytokine release against allogeneic cancer cell line by direct recognition and antibody directed cellular cytotoxicity: therapeutic potential use of NK cells for blood and solid tumors
Authors: Abdelhamid Liacini, Noureddine Berka, Faisal Khan
Journal: Journal for ImmunoTherapy of Cancer (2014)

Meeting abstracts Implementation of NK cell therapy is faced by several obstacles: the small number of NK cells in peripheral blood and the difficulties regarding production of effective cytolytic NK cells. We carried out this pilot study to determine if NK cells could be expanded and their
Suctioning and Length of Stay in Infants Hospitalized With Bronchiolitis
Authors: Grant M. Mussman, Michelle W. Parker, Angela Statile, Heidi Sucharew, Patrick W. Brady
Journal: JAMA Pediatrics (2013)

Hospitalizations of infants for bronchiolitis are common and costly. Despite the high incidence and resource burden of bronchiolitis, the mainstay of treatment remains supportive care, which frequently includes nasal suctioning.To examine the association between suctioning device type and suctioning lapses greater than 4 hours within the first 24 hours after hospital admission on length of stay (LOS) in infants with bronchiolitis.Retrospective cohort study. Data were extracted from the electronic health record.Main hospital and satellite facility of a large quaternary care children's hospital from January 10, 2010, through April 30, 2011.A total of 740 infants aged 2 to 12 months and hospitalized with bronchiolitis.Hospital LOS.In the multivariable model adjusted for inverse weighting for propensity to receive deep suctioning, increased deep suction as a percentage of suction events was associated with increased LOS with a geometric mean of 1.75 days (95% CI, 1.56-1.95 days) in patients with no deep suction and 2.35 days (2.10-2.62 days) in patients with more than 60% deep suction. An increased number of suctioning lapses was also associated with increased LOS in a dose-dependent manner with a geometric mean of 1.62 days (95% CI, 1.43-1.83 days) in patients with no lapses and 2.64 days (2.30-3.04 days) in patients with 3 or 4 lapses.For patients admitted with bronchiolitis, the use of deep suctioning in the first 24 hours after admission and lapses greater than 4 hours between suctioning events were associated with longer LOS.
Medact report highlights aftermath of Iraq conflict
Authors: J. Clark
Journal: BMJ (2003)

Months after armed combat against Iraq has ended, the devastating health and environmental effects of the conflict continue and may persist for generations, says a new report from Medact, the UK based charity of health professionals highlighting the health impacts of war and conflict.

The report, a follow up to the charity's 2002 document Collateral Damage ( BMJ 2002 325:1134), contains the results of an eight month survey of publicly available health data and expert organisations in and outside Iraq. Medact estimates that as many as …
Statistical tools for synthesizing lists of differentially expressed features in related experiments
Authors: Marta Blangiardo, Sylvia Richardson
Journal: Genome biology (2007)

Abstract We propose a novel approach for finding a list of features that are commonly perturbed in two or more experiments, quantifying the evidence of dependence between the experiments by a ratio. We present a Bayesian analysis of this ratio, which leads us to suggest two rules for choosing a cut-off on the ranked list of p values. We evaluate and compare the performance of these statistical tools in a simulation study, and show their usefulness on two real datasets.
BFR (bendamustine, fludarabine, and rituximab) allogeneic conditioning for chronic lymphocytic leukemia/lymphoma: reduced myelosuppression and GVHD
Authors: Issa F. Khouri, Wei Wei, Martin Korbling, Francesco Turturro, Sairah Ahmed, Amin Alousi, Paolo Anderlini, Stefan Ciurea, Elias Jabbour, Betul Oran, Uday R. Popat, Gabriela Rondon, Roland L. Bassett, Alison Gulbis
Journal: Blood (2014)
1004 A PROSPECTIVE COHORT STUDY ON ENTECAVIR TREATING PATIENTS WITH ACUTE ON CHRONIC HEPATITIS B LIVE FAILURE (ACHBLF)
Authors: L. Bingliang, X. Dongying, X. Junqiang, Z. Xiaohong, X. Shibing, H. Yubo, G. Zhiliang
Journal: Journal of Hepatology (2010)
THE ASSOCIATION OF PHOTOSENSITIVITY AND ATOPY IN THE CHILD
Authors: W. FRAIN-BELL, M. SCATCHARD
Journal: British Journal of Dermatology (1971)

Journal Article THE ASSOCIATION OF PHOTOSENSITIVITY AND ATOPY IN THE CHILD Get access W. FRAIN‐BELL, W. FRAIN‐BELL Department of Dermatology, University of Dundee, Scotland Search for other works by this author on: Oxford Academic Google Scholar M. SCATCHARD M. SCATCHARD Department of Dermatology, University of Dundee, Scotland Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 85, Issue 2, 1 August 1971, Pages 105–110, https://doi.org/10.1111/j.1365-2133.1971.tb07193.x Published: 01 August 1971 Article history Accepted: 09 January 1971 Published: 01 August 1971
Building the Field of Health Policy and Systems Research: Framing the Questions
Authors: Kabir Sheikh, Lucy Gilson, Irene Akua Agyepong, Kara Hanson, Freddie Ssengooba, Sara Bennett
Journal: PLoS Medicine (2011)

In the first of a series of articles addressing the current challenges and opportunities for the development of Health Policy & Systems Research (HPSR), Kabir Sheikh and colleagues lay out the main questions vexing the field.
Immediate impression of the utility of transesophageal echo is confirmed at follow-up: V.O.T.E. II study
Authors: Ravin Davidoff, Abbas Gohal, Heather Florescue, Michael Picard, Steven Goldstein, Steven Schwartz, Michael Motro, Zvi Vered, Daniel Bicardo, Itzhak Kronzon, Shunichi Homma, MaryAnn McLaughlin, Lee Goldman, Martin E. Goldman
Journal: Journal of the American College of Cardiology (1996)
The Biosynthesis of Collagen
Authors: Michael E. Grant, Darwin J. Prockop
Journal: New England Journal of Medicine (1972)

Micro-Heterogeneity in the Biosynthesis of CollagenDetailed analyses of the structure of the polypeptide chains of collagen has revealed a "micro-heterogeneity" of the amino acid sequences. Sequencing of the first 50 amino acid residues from the NH2-terminal end of the α1 chain of rat skin and tendon collagen indicated that although there were several triplets of the structure -Gly-X-Hypro-, an appreciable fraction of the amino acid in the third position of such triplets was Pro rather than Hypro.109,110 A similar situation has been found for Hypro in most109,110,139,140 but not all141,142 of the triplets that have been . . .
Right-Sided Aortic Arch
Authors: William F. Boyle, Christopher C. Shaw
Journal: New England Journal of Medicine (1957)

THE aorta and its main branches develop from six pairs of branchial arches, which, during the fourth week of pregnancy, conjoin the primitive ventral and dorsal aortas in the embryo.1 In the human being, these six branchial arches become transferred into the permanent major vessels (the aorta and its main branches) during the fifth to the seventh week of embryologic development. Normally, the first and second pairs of arches are absorbed and disappear entirely. The carotid arteries are derived from the third pair of arches. The fourth branchial arch on the left forms the arch of the aorta whereas its . . .
P1173 THE IMPACT OF HIV CO-INFECTION ON RATES AND SEVERITY OF ANEMIA OCCURRING DURING TREATMENT WITH SOFOSBUVIR-CONTAINING HCV REGIMENS: A POOLED ANALYSIS
Authors: S. Naggie, M. Sulkowski, A. Gaggar, L. Stamm, L. Ni, D. Brainard, W. Symonds, J. McHutchison, D. Dieterich, M. Rodriguez-Torres
Journal: Journal of Hepatology (2014)
Consciousness organizes more than itself: Findings from subliminal mere exposure research
Authors: Robert F. Bornstein
Journal: Behavioral and Brain Sciences (2002)

Contrary to Perruchet &amp; Vinter's self-organizing consciousness (SOC) model, subliminal mere exposure (SME) research indicates that stimuli perceived without awareness produce robust effects. Moreover, SME effects are significantly stronger than mere exposure effects produced by clearly recognized stimuli. The SOC model must be revised to accommodate findings from studies that use affect-based outcome measures.
Waterborne Mycobacterium avium Infection
Authors: Pablo Yagupsky
Journal: JAMA (1989)

<h3>To the Editor. —</h3> In a recently published article, du Moulin et al<sup>1</sup>studied hospital tap water for the presence of mycobacteria.<i>Mycobacterium avium</i>, a frequent opportunistic pathogen among patients with the acquired immunodeficiency syndrome (AIDS), was isolated from 41% of the sites investigated.<i>Mycobacterium avium</i>was isolated more frequently from hot water than from cold water and at higher concentrations. The authors suggested that potable hot water systems, by creating aerosols, could serve as environmental sources for<i>M avium</i>infection in AIDS patients, and proposed raising the temperature of hot water to decrease the concentration of mycobacteria and cautioning patients to avoid hot water aerosols by bathing instead of showering to reduce exposure to M avium. Such measures might be reasonable to consider if the pathogenesis and route of infection in AIDS patients were well established. However, it is not yet known whether disseminated<i>M avium</i>disease in
Informing the 2011 UN Session on Noncommunicable Diseases: Applying Lessons from the AIDS Response
Authors: Peter Lamptey, Michael Merson, Peter Piot, K. Srinath Reddy, Rebecca Dirks
Journal: PLoS Medicine (2011)

In advance of the September 2011 UN Summit on non-communicable diseases (NCDs), Rebecca Dirks and colleagues identify lessons from the AIDS epidemic that can inform the response to the growing epidemic of NCDs.
Letter: Hepatic necrosis and trimethoprim-sulfamethoxazole
Authors: C. F. Colucci
Journal: JAMA (1975)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Role of IGF Binding Protein- 1 in the Dawn Phenomenon and Glycemic Control in Children and Adolescents With IDDM
Authors: Kisho Kobayashi, Shin Amemiya, Emi Sawanobori, Kosuke Higashida, Toshihide Ishihara, Koji Kobayashi, Kiyohiko Kato, Shinpei Nakazawa
Journal: Diabetes Care (1997)

OBJECTIVE To clarify the involvement of IGF binding protein (IGFBP)-1 in the dawn rise in plasma glucose and in the overall glycemic control in patients with IDDM. RESEARCH DESIGN AND METHODS Seventy patients with IDDM were divided into three groups according to pubertal development. Blood samples were obtained for measuring plasma glucose, IGFBP-1, and free insulin at 2200, 0500, and 0700 over a 2-day period. Levels of HbA1c, IGF-1, and IGFBP-3 were determined at 0700. Urinary growth hormone (GH) was collected overnight. To examine its frequency, the dawn phenomenon was defined on the basis of the following: 1) change in plasma glucose from 0500 to 0700, 2) plasma glucose level at 0700, and 3) no antecedent hypoglycemia. RESULTS There was a statistically significant link between the dawn changes in plasma glucose and IGFBP-1 (r = 0.37, P &amp;lt; 0.01). The former was not related to the change in free insulin or to the overnight urinary GH level. In stepwise regression analyses, plasma glucose at 0700 = 0.03 IGFBP-1 (P &amp;lt; 0.01) + 0.525 HbA1c (P &amp;lt; 0.01) + 3.696 (R2 = 51%). Approximately half of the patients in each group exhibited the dawn phenomenon; 38% of patients with HbA1c &amp;lt; 8% also showed the dawn phenomenon. CONCLUSIONS We have demonstrated a statistically significant link between the morningrisk in IGFBP-1 and plasma glucose. The free fraction of IGF-1 modulated by acute changes in IGFBP-1 may play a direct role. The dawn phenomenon may occur regardless of pubertal stage or glycemic control in children and adolescents with IDDM.
PARALYSIS FOLLOWING ARTERIAL INJURIES
Authors: H. Burrows
Journal: BMJ (1918)

PAIAALYSIS FOLLOWING ARTERIAL INJURIES.( MIzaLB3ouwm I99 Peans of a syringe, or by more frequent waslings, as in the Carrel-Dakin treatment, will depend on various factors, suclh as personal predisposition, nursing facilities and idiosyncrasies of the patient.It would seenu natural to suppose that quicker and surer results could be obtained by the two-lhourly fluishings of Carrel-Dakin than the daily or twice daily flushings by syringe wlhen dressing the case.Conclusions.