tbuckley/cabot-search huggingface dataset:
Prognostic Value and Temporal Behavior of the Planar QRS-T Angle in Patients With Nonischemic Cardiomyopathy
Authors: Behzad B. Pavri, Matthew B. Hillis, Haris Subačius, Genevieve E. Brumberg, Andi Schaechter, Joseph H. Levine, Alan Kadish
Journal: Circulation (2008)

The planar QRS-T angle can be easily obtained from standard 12-lead ECGs, but its predictive ability is not established. We sought to determine the predictive ability of the planar QRS-T angle in patients with nonischemic cardiomyopathy and to assess QRS-T angle behavior over time.Baseline QRS-T angles from 455 patients in the Defibrillators in Nonischemic Cardiomyopathy Treatment Evaluation (DEFINITE) trial were measured. All patients had nonischemic cardiomyopathy, New York Heart Association class I to III heart failure, and nonsustained ventricular tachycardia or frequent ventricular ectopy. The primary end point (a composite of total mortality, appropriate implantable cardioverter-defibrillator shock, or resuscitated cardiac arrest) occurred in 25 of 172 patients (14.5%) with a QRS-T angle < or =90 degrees and in 72 of 283 patients (25.4%) with a QRS-T angle >90 degrees (hazard ratio, 1.93; 95% confidence interval, 1.23 to 3.05; P=0.002). A QRS-T angle >90 degrees remained a significant predictor of the primary end point (P=0.039) after adjustment for treatment group, age, gender, QRS duration, left bundle-branch block, left ventricular ejection fraction, New York Heart Association class III, atrial fibrillation, and diabetes mellitus. The secondary end point (total mortality) occurred in 17 of the 172 patients (9.9%) with a QRS-T angle < or =90 degrees and in 49 of the 283 patients (17.3%) with a QRS-T angle >90 degrees (hazard ratio, 1.79; 95% confidence interval, 1.03 to 3.10; P=0.016). A sample of 152 patients with multiple follow-up ECGs was analyzed to assess temporal QRS-T angle behavior. Changes in the QRS-T angle correlated with changes in left ventricular ejection fraction and QRS duration over time (P<0.001).A planar QRS-T angle >90 degrees is a significant predictor of a composite end point of death, appropriate implantable cardioverter-defibrillator shock, or resuscitated cardiac arrest in nonpaced, mild to moderately symptomatic patients with nonischemic cardiomyopathy with frequent or complex ventricular ectopy. QRS-T angles changed predictably with left ventricular ejection fraction and QRS duration.
Abstract P4-01-06: High resolution breast PET for monitoring response of breast cancer to neoadjuvant chemotherapy
Authors: JC Nelson, NL Lehde, CJ Green, J Villanueva-Meyer
Journal: Cancer Research (2013)

Abstract Purpose: To evaluate the sensitivity and accuracy of high resolution breast PET for monitoring the response of breast cancer to neoadjuvant chemotherapy. Patients and Methods: High resolution breast PET imaging was performed in 29 women before and following the completion of neoadjuvant chemotherapy in this retrospective patient review study. Tumors were divided into three receptor subtype categories: triple negative, human epidermal growth factor receptor 2 (HER2) positive, and estrogen receptor (ER) positive/HER2 negative. Breast PET was used to characterize lesion morphology, size and maximum FDG uptake. Lesion FDG uptake to background glandular FDG uptake (LTB) was used to allow comparison between imaging studies. Tumor response was assessed dichotomously (i.e. presence or abscence of residual tumor in the surgical specimen) and results were compared to breast PET findings. For discrepant findings, retrospective re-review of the breast PET images was completed with full LTB ratio and Grey/Red evaluation. Results: The average age of the patients was 52.6 years (range 24 - 72 years). Pathology found residual tumor in 66% (19/29). Breast PET images correctly identified residual disease in 17/19 patients and correctly predicted a complete pathological response in 9/10 patients for an overall accuracy of 90% (26/29). One tumor was missed due to poor positioning and a second (&amp;lt;1mm in size) was not identified. One breast PET showed residual uptake which was found to be sclerosis on pathology. The cancer subtype with the highest FDG uptake before chemotherapy was the triple negatives with a LTB ratio of 17.4, next highest was the HER2+ at 16.7 while the HER2 negative group showed the lowest metabolic activity at 11.1. One patient with two tumors in the same breast showed total response of one tumor to neoadjuvant chemotherapy while the second tumor grew in size. Conclusion: High resolution breast PET was highly accurate in identifying tumor response to neoadjuvant chemotherapy. Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P4-01-06.
PROBABLE ERRORS IN THE SIMULTANEOUS MEASUREMENT OF SEPARATE KIDNEY FUNCTIONS
Authors: Calvin Klopp, Nelson F. Young, Howard C. Taylor
Journal: Journal of Clinical Investigation (1945)

The methods developed by Smith and his associates have made possible the separate measurement of glomerular filtration, the effec- tive renal blood flow, and the total functioning mass of tubular tissue (1).During a recent study of the effects of certain steroids on these renal functions in man, it became apparent that their determination could not always be made simultaneously since the administration of test substances for the determination of one function interfered with the determination of another.The extent and manner of this interference is the subject of the present communication. METHODSA. The plasma clearance of mannitol (CM) was used as a measure of glomerular filtration (1).Plasma levels of the compound were maintained between 90 and 200 mgm.per cent.B. The plasma clearance of p-amino hippuric acid (PAH) at levels of from 0.8 to 3.0 mgm.per 100 ml.plasma was used as an index of effective renal blood flow.At these levels, PAH is removed completely from the plasma in a single passage through the kidney (2).C. The functioning tubular mass (Tm) was ascertained by two methods.These were: (1) p-Amino hippuric acid Tm (TmPAH), a measure of the maximum ability of the kidney tubules to secrete that substance (3); plasma
Expression of MAGE, GAGE and BAGE genes in human liver diseases: utility as molecular markers for hepatocellular carcinoma
Authors: Yoshiyuki Kobayashi, Toshihiro Higashi, Kazuhiro Nouso, Harushige Nakatsukasa, Masahiko Ishizaki, Toshihiko Kaneyoshi, Nobuyuki Toshikuni, Kazuya Kariyama, Eiichi Nakayama, Takao Tsuji
Journal: Journal of Hepatology (2000)
FENOFIBRIC AND NICOTINIC ACID PROGRESSIVELY SUPPRESS POSTPRANDIAL TRIGLYCERIDEMIA IN STATIN-TREATED PATIENTS WITH LOW HIGH-DENSITY LIPOPROTEIN CHOLESTEROL
Authors: Richard L. Dunbar, Ramprasad Gadi, Amanda Baer, Harsh Goel, Aurangzeb Baber, Mohammad Rehan, Daniel J. Rader, John Millar
Journal: Journal of the American College of Cardiology (2010)
The rationality of suicide bombers: There is a little bit of crazy in all of us
Authors: Valerie Gray Hardcastle
Journal: Behavioral and Brain Sciences (2014)

Abstract Despite Lankford's descriptions of escapist suicide victims as being unstable, they were making rational decisions, based on their current knowledge and values. Similarly, those who are allegedly indirectly suicidal are not different from other risk-takers. The psychological differences between those who engage in suicidal attacks and those who do not are less than most of us would prefer.
Medical Management of Peripheral Arterial Occlusive Diseases
Authors: Stanford Wessler
Journal: New England Journal of Medicine (1953)

THE treatment of the patient with peripheral arterial insufficiency is increasingly successful. During the course of the disease, however, the physician is frequently called upon to resolve problems about which there is diversity of opinion. These include the significance of vascular calcification, the value of arteriography, the hazards of nicotine, the role of anticoagulant and antispasmodic drugs, the treatment of intermittent claudication, the therapy of acute arterial obstruction and the prophylaxis and management of impending or frank ulceration and gangrene. Finally, opinions differ concerning the indications for sympathectomy, embolectomy, segmental arterial resection and amputation. It is the aim of this . . .
Cushing's Syndrome Associated With Adrenomedullary Hyperplasia
Authors: Yoh-Ichiro Kazama
Journal: JAMA (1986)

To the Editor.—  The association of Cushing's syndrome with increased urinary excretion of catecholamines has been reported, for example, in patients with adrenocorticotropic hormone-secreting pheochromocytoma, 1 or with mixed adrenocortical and medullary tumors. 2 The present report describes a patient with Cushing's syndrome who showed increased urinary excretion of norepinephrine due to the coexistence of adrenal medullary hyperplasia.  Report of a Case.—  A 57-year-old man, who had hypertension and diabetes mellitus for ten years, was admitted to the hospital because of thirst, lassitude, and muscle wasting. He was found to have central obesity, and his face was round and fiery red. At the time of admission, his blood pressure was 180/80 mm Hg and the fasting serum glucose level was 114 mg/dL. His daily requirement of insulin was 28 units. Estimations of plasma cortisol values showed elevated hormone levels without diurnal variation (25.0 and 20.0 μg/dL at 7 AM and
Results of resection for bronchogenic carcinoma in patients over the age of 80.
Authors: T Shirakusa, M Tsutsui, N Iriki, K Matsuba, T Saito, S Minoda, T Iwasaki, N Hirota, J Kuono
Journal: Thorax (1989)

Thirty three patients aged over 80 years underwent resection for bronchogenic carcinoma. The operations performed were: lobectomy (21), segmentectomy (4), wedge resection (2), pneumonectomy (3), carinal resection (1). In two patients no resection was feasible. Three patients died within two months of surgery. The cumulative five year survival rate was 55%, 79% for patients with stage I carcinoma and 31% for stage III. It is considered that resection has an acceptable outcome in patients over 80 years.
1291 COMPLEMENT ALTERNATIVE PATHWAY ACTIVATION IS ASSOCIATED WITH SEVERITY OF NONALCOHOLIC STEATOHEPATITIS
Authors: F.M. Segers, F.J. Verdam, C. de Jonge, B. Boonen, N.D. Bouvy, J.W.M. Greve, W.A. Buurman, S.S. Rensen
Journal: Journal of Hepatology (2013)
Membranous glomerulonephritis in chronic lymphocytic leukemia
Authors: Panayiotis D. Ziakas, Stavroula Giannouli, Erasmia Psimenou, Lydia Nakopoulou, Michalis Voulgarelis
Journal: American Journal of Hematology (2004)

Abstract We present a case of chronic lymphocytic leukemia associated with nephrotic syndrome. Renal biopsy revealed membranous glomerulonephritis accompanied by interstitial monoclonal lymphocytic infiltration. Combination therapy with cyclophosphamide, vincristine, and prednisone (COP) was successful in inducing an effective response in chronic lymphocytic leukemia. Improvement of renal function and proteinuria was also observed. Am. J. Hematol. 76:271–274, 2004. © 2004 Wiley‐Liss, Inc.
Highly angiogenic CXCR4+CD31+ monocyte subset derived from 3D culture of human peripheral blood
Authors: Jin Hur, Jae-Il Choi, Ji-Yeon Yun, Chang-Hwan Yoon, Jae Hee Jang, Seung-Gyun Im, Seung-Bum Ko, Jin-A. Kang, Jonghanne Park, Sang Eun Lee, Ju-Young Kim, Han-Mo Yang, Young-Bae Park, Hyo-Soo Kim
Journal: Biomaterials (2012)
Relationship between arterial pressure and the permeability of arterioles to carbon particles in acute hypertension in the rat
Authors: F. S. GOLDBY, L. J. BEILIN
Journal: Cardiovascular Research (1972)

Acute pressor responses to angiotensin, renal extract, and noradrenaline caused irregularity of calibre in the mesenteric arterioles of the rat. The dilated segments of arterioles were permeable to intravenously injected carbon particles, the constricted segments were not. The degree of carbon deposition was related to the mean arterial pressure and not to the dose or nature of the pressor substance. It is suggested that carbon deposition is the result of structural damage to the vessel wall caused by the inability of vascular smooth muscle to withstand high arterial pressure. No evidence was found for the action of a vascular permeability factor of renal origin.
Tonsillectomy and Poliomyelitis
Authors: Gaylord W. Anderson
Journal: JAMA (1963)

<h3>To the Editor:</h3> —The lead editorial of the Sept 1 issue ofThe Journal(<b>181</b>:784) referred to an article on tonsillectomy and poliomyelitis by Dr. Ravenholt of Seattle which was published in the May, 1962, issue of the<i>American Journal of Diseases of Children</i>. In this study, Dr. Ravenholt fails to find any higher incidence of bulbar polio among those who have had their tonsils removed more than a month earlier than among those who still have their tonsils in situ. Your editorial states that Dr. Ravenholt "has presented convincing evidence that bulbar paralysis is not more frequent in tonsillectomized patients" and later that "Previous reports of this association were not supported by age-specific data." I do not know the origin of this editorial, but I am concerned about its inaccuracies and especially the inferences that would be drawn by one who read the editorial but not the original
Some Aspects of the Biological Role of Adenosine 3',5'-monophosphate (Cyclic AMP)
Authors: EARL W. SUTHERLAND, G. ALAN ROBISON, REGINALD W. BUTCHER
Journal: Circulation (1968)

Cyclic AMP (adenosine 3',5'-monophosphate or cyclic adenylate) has now been established as a second messenger mediating many of the effects of a variety of hormones. Several of the metabolic effects mediated by cyclic AMP are discussed, and it is suggested that certain other ("functional" or "mechanical") hormonal effects may be similarly mediated. In particular, the evidence presented supports the hypothesis that the positive inotropic response to the catecholamines is mediated by cyclic AMP. Although knowledge of the biological role of cyclic AMP has not been widely applied clinically, sufficient knowledge has now accumulated to make research in this area desirable.
Hemoglobin Components in Diabetes Mellitus: Studies in Identical Twins
Authors: Robert B. Tattersall, David A. Pyke, Helen M. Ranney, Sally M. Bruckheimer
Journal: New England Journal of Medicine (1975)

The minor components of hemoglobin which are increased in subjects with diabetes mellitus, hemoglobin Ala-c, were measured in identical twins concordant and discordant for diabetes to determine whether the observed increases represent a genetically determined abnormality. The mean values for the proportion of hemoglobins Ala-c in discordant twins differed markedly in the two members of the pair: 10.4 +/- 0.74 per cent for the diabetic twins and 6.85 +/- 0.33 for the nondiabetic twins (t = 4.3811, P less than 0.005). In concordant twins with juvenile onset diabetes, the mean proportion of Hb Ala-c was 11.4 per cent, and no marked differences were observed between members of twin pairs. Four pairs of identical twins concordant for maturity onset diabetes showed lower mean values for Hb Ala-c but did not show marked intra-pair differences. Thus, the abnormal proportions of hemoglobins Ala-c found in the presence of overt diabetes mellitus appear to be a manifestation of a metabolic abnormality of diabetes.
Resection of a leiomyoma of the descending thoracic aorta.
Authors: G Gula, A Cancrini, L Provenzale
Journal: Thorax (1976)

A primary aortic neoplasm in a 4-year-old asymptomatic boy is described. At operation the tumour was found to originate from the descending thoracici aorta. Histologically it proved to be a leiomyoma. The operative findings and pathological features are briefly discussed.
P709A Novel MDM2 inhibitor, SM13, induces p53-dependent apoptosis in vascular smooth muscle cell
Authors: C Del Giudice, A Bertamino, P Campiglia, B Trimarco, G Iaccarino, D Sorriento
Journal: Cardiovascular Research (2014)

p53 is a known tumor suppressor which leads to apoptotic events in after cellular damage, and it regulates cell cycle arrest and apoptosis. p53 is active in vascular hyperplastic lesions, where it regulates apoptosis of rat aorta Vascular Smooth Muscle Cell (VSMC). Targeting p53 may be, therefore, a novel therapeutic approach for the treatment of restenosis. We have recently characterized a new compound, SM13, which is able to increase p53 by disrupting p53-MDM2 interaction, and its ubiquitination and degradation. Aim of this study is to evaluate p53 ability to inhibit VSMC proliferation. First, we confirmed in VSMC that SM13 efficiently reduces p53/MDM2 interaction and increases p53 levels. SM13 inhibited VSMC proliferation and DNA synthesis in response to FBS 5% in a time dependent manner. Accordingly, the phosphorylation of RB, marker of cell cycle progression, was reduced in SM13 treated cells. In order to evaluate the effect of SM13 on apoptosis, we analyzed the activation of caspase 3. SM13 increased the levels of cleaved caspase 3 suggesting that it regulates proliferation in vitro by inducing p53-dependent apoptosis. In conclusion, our results demonstrate the effectiveness of SM13 to reduce VSMC proliferation, through the activation of a p53-dependent apoptotic pathway and suggest to test it for treatment of vascular disease, in experimental animal model.
Hemangiopoietin, a novel human growth factor for the primitive cells of both hematopoietic and endothelial cell lineages
Authors: Yong Jun Liu, Shi Hong Lu, Bin Xu, Ren Chi Yang, Qian Ren, Bin Liu, Bin Li, Min Lu, Feng Ying Yan, Zhi Bo Han, Zhong Chao Han
Journal: Blood (2004)
"Virtually static" NHS productivity puts prospect of savings at risk
Authors: H. Mooney
Journal: BMJ (2010)

The NHS is showing few signs that it will be able to make the changes needed to save the £20bn (€24bn; $31bn) government target, the UK’s Audit Commission watchdog has warned.

A new report, More for Less 2009/10 , reveals how and where primary care trusts spent their money last year. It shows that many key markers of success in improving NHS productivity have remained “virtually static.”

Although the Audit Commission says that primary care trusts can make savings through cutting staffing costs, increasing day surgery, and reducing emergency admissions, much wider changes will be needed across the NHS if it is to save up …
Improved formulations of antisense oligodeoxynucleotides using wrapped liposomes
Authors: Masahiro Yamauchi, Hiroko Kusano, Etsuko Saito, Takeshi Iwata, Masashi Nakakura, Yasuki Kato, Takaaki Uochi, Shiro Akinaga, Noboru Aoki
Journal: Journal of Controlled Release (2006)
THE FUNCTION OF THE SPLEEN IN THE EXPERIMENTAL INFECTION OF ALBINO MICE WITH BACILLUS TUBERCULOSIS
Authors: Paul A. Lewis, Arthur Georges Margot
Journal: The Journal of Experimental Medicine (1914)

Infection of rats and mice with Bacillus tuberculosis (bovine type) develops a splenic tumor as a typical lesion. Removal of the spleen from mice (albino) greatly increases their resistance to the infection. This increased resistance cannot be explained at present. The infection in the splenectomized mice tends to remain localized as contrasted with an almost septicemic type of disease which is usual in the normal animal. The animals of each group that live more than thirty days are apt to present typical exudative lesions. The removal of the spleen does not therefore grossly change what may be called the capacity of the body for exudation.
2015 GENOME WIDE ANALYSIS OF PATIENTS FROM THE IDEAL STUDY IDENTIFIES A CAUSAL ROLE FOR ITPA GENETIC VARIATION IN RIBAVIRIN-INDUCED HEMOLYTIC ANEMIA
Authors: A.J. Thompson, J. Fellay, D. Ge, T. Urban, K. Shianna, M. Sulkowski, A. Muir, N. Afdhal, I. Jacobson, R. Esteban, F. Poordad, E. Lawitz, J. Mc Cone, M. Shiffman, G. Galler, W. Lee, R. Reindollar, J. King, P. Kwo, R. Ghalib, B. Freilich, L. Nyberg, K. Patel, H. Tillmann, S. Noviello, N. Bopari, K. Koury, L. Pedicone, C. Brass, J.K. Albrecht, D. Goldstein, J.G. Mc Hutchison
Journal: Journal of Hepatology (2010)
Clinicians out of fashion for the Nobel Prize in Medicine and Physiology
Authors: Alan F Hofmann
Journal: Journal of the Royal Society of Medicine (2011)

Ashrafian et al. propose that the proportion of clinicians receiving the Nobel Prize for discoveries in Physiology and Medicine is decreasing.1 I believe that Alfred Nobel and his advisors could never have envisioned the explosive development of biochemistry, pharmacology, cell biology and genetics that would occur in the 20th century. In 1895, the year that Nobel's will was opened, there was not a single professor of Biochemistry, Pharmacology, Cell Biology or Genetics in the United States or Great Britain. The present categories of prizes are probably immutable. Were they to be altered to reflect current research activity, one could reasonably propose that an additional category of ‘biology’ be added for seminal discoveries in the basic sciences mentioned above.
Burn Toxaemia Treated by Rapid Vene-section and Transfusion
Authors: M. C. Oldfield
Journal: BMJ (1947)

Stsite Medical ServiceSIR,-It is, I think, high time that we were told of the negotiations at present going on between the B.M.A. and the Government.What are the conditions ?What is to happen to existing stocks of drugs, dressings, etc. ?
Effects of ursodeoxycholic acid on serum liver enzymes and bile acid metabolism in chronic active hepatitis: A dose-response study
Authors: Andrea Crosignani, Pier Maria Battezzati, Kenneth D. R. Setchell, Maurizia Camisasca, Emanuela Bertolini, Aldo Roda, Massimo Zuin, Mauro Podda
Journal: Hepatology (1991)

The effect of ursodeoxycholic acid administration on liver function tests and on bile acid metabolism was investigated in 18 patients with chronic active hepatitis. Three different doses of ursodeoxycholic acid--250 mg, 500 mg and 750 mg--were administered daily to each patient for consecutive 2-mo periods. The order of doses was randomly assigned according to a replicated Latin-square design. A significant decrease in serum transaminases and gamma-glutamyl transpeptidase occurred with the lowest dose of ursodeoxycholic acid, which corresponded to 4 mg/kg body wt/day, and no further significant decrease with the higher doses was seen. Biliary bile acid composition was determined by high-performance liquid chromatography and gas chromatography-mass spectrometry. At entry the relative proportions of major bile acids were similar to those observed in normal individuals. During treatment the mean percentage of ursodeoxycholic acid in bile (22% with the 250 mg dose, 32% with the 500 mg dose and 34% with the 750 mg dose) was lower than values previously reported for patients with gallstones and normal liver function. The major bile acids were cholic, chenodeoxycholic and deoxycholic acids. A number of unusual bile acids were identified by gas chromatography-mass spectrometry, but these accounted for only 3% to 5% of the total and did not change during ursodeoxycholic acid therapy. No correlation between the improvement in liver function tests and the percentage of ursodeoxycholic acid in bile existed. These data suggest that even a slight enrichment of bile with ursodeoxycholic acid, as is attained with 250 mg/day, is effective in improving biochemical markers of liver function in patients with chronic active hepatitis.
An intergenic region on chromosome 13q33.3 is associated with the susceptibility to kidney disease in type 1 and 2 diabetes
Authors: Marcus G. Pezzolesi, G. David Poznik, Jan Skupien, Adam M. Smiles, Josyf C. Mychaleckyj, Stephen S. Rich, James H. Warram, Andrzej S. Krolewski
Journal: Kidney International (2011)
How Can You Patent Genes?
Authors: Rebecca S. Eisenberg
Journal: The American Journal of Bioethics (2002)

What accounts for the continued lack of clarity over the legal procedures for the patenting of DNA sequences? The patenting system was built for a "bricks-and-mortar" world rather than an information economy. The fact that genes are both material molecules and informational systems helps explain the difficulty that the patent system is going to continue to have.