tbuckley/cabot-search huggingface dataset:
Abstract 515: Aurora-A is a determinant of tamoxifen resistance by phosphorylation and activation of ERα in breast cancer.
Authors: Xiangqian Zheng, Jianping Guo, Hua Yang, Lili He, Masayuki Kanai, Domenico Coppola, Ming Gao, Xiubao Ren, Jin Q. Cheng
Journal: Cancer Research (2013)

Abstract Aurora-A kinase is frequently overexpressed/activated in various types of human malignancy including breast cancer. In this study, we demonstrated that Aurora-A induces estrogen receptor α (ERα) transactivation activity in the presence and absence of estrogen. Aurora-A also interacts with and phosphorylates ERα at serine-167 and -305 in vitro and in vivo. As a result, Aurora-A induces ERα transcriptional activity, enhances ERα binding to DNA and transcriptionally up-regulates its targeting genes such as CCDN1 in a phospho-ERα-Ser-167/305 dependent manners. Further, overexpression of Aurora-A decreases whereas depletion of Aurora-A enhances tamoxifen sensitivity in ERα-positive breast cancer cells. Significantly, Aurora-A inhibitor synergized with tamoxifen and overcame tamoxifen-resistance in vitro and in animal model. These data suggest that ERα is a bona fide substrate of Aurora-A and that Aurora-A plays a pivotal role in tamoxifen resistance. Thus, Aurora-A represents a critical therapeutic target in breast cancer endocrine-therapy. Citation Format: Xiangqian Zheng, Jianping Guo, Hua Yang, Lili He, Masayuki Kanai, Domenico Coppola, Ming Gao, Xiubao Ren, Jin Q. Cheng. Aurora-A is a determinant of tamoxifen resistance by phosphorylation and activation of ERα in breast cancer. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 515. doi:10.1158/1538-7445.AM2013-515
Visual Problems of Color. Proceedings of a Symposium held at the (British) National Physical Laboratory, September, 1957
Authors: F. B. Exner
Journal: JAMA (1962)

These volumes open with a Selig Hecht commemorative lecture by Prof. George Wald of Harvard, followed by 3 tributes to Hecht by British and American authorities. These are followed by 40 papers on recent investigations: 12 British, 10 each from the United States and Russia, and 1 each from Canada, France, Italy, Spain, Holland, Sweden, Finland, and Venezuela. There are 2 barriers to easy understanding by the novice, but they are not insuperable and the effort needed for understanding is well rewarded. The first is the number of new words and new uses for old words that comprise the jargon of the participants. In general, however, these eventually become clear in the context. The second barrier lies in the rather technical, and sometimes mathematically obscure, nature of some of the papers. However, most of the papers carry excellent summaries in English. The collective effect reveals that the present state of
TCTAP A-159 Impact of Percutaneous Coronary Intervention for Chronic Total Occlusion in Stroke Patients
Authors: Seung-Woon Rha, Byoung Geol Choi, Se Yeon Choi, Yoonjee Park, Akkala Raghavender Goud, Hu Li, Sunki Lee, Ji Bak Kim, Sung Il Im, Jin Oh Na, Cheol Ung Choi, Hong Euy Lim, Jin Won Kim, Eung Ju Kim, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh
Journal: Journal of the American College of Cardiology (2014)
SLAM is a microbial sensor that regulates bacterial phagosome functions in macrophages
Authors: Scott B Berger, Xavier Romero, Chunyan Ma, Guoxing Wang, William A Faubion, Gongxian Liao, Ewoud Compeer, Marton Keszei, Lucia Rameh, Ninghai Wang, Marianne Boes, Jose R Regueiro, Hans-Christian Reinecker, Cox Terhorst
Journal: Nature Immunology (2010)
Biomonitoring Studies Should Be Used by Regulatory Agencies to Assess Human Exposure Levels and Safety of Bisphenol A
Authors: Laura N. Vandenberg, Ibrahim Chahoud, Vasantha Padmanabhan, Francisco J.R. Paumgartten, Gilbert Schoenfelder
Journal: Environmental Health Perspectives (2010)

BackgroundWithin the past 3 years, four major evaluations of bisphenol A (BPA) safety have been undertaken. However, these assessments have arrived at quite different conclusions regarding the safety of BPA at current human exposure levels.ObjectivesWe compared the reasons provided by the European Food Safety Authority (EFSA) BPA risk assessment panel for their conclusion that human exposures are negligible with the conclusions reached by the other panels, with all panels having the same body of literature at their disposal.DiscussionThe EFSA panel dismissed ≥ 80 biomonitoring studies that documented significant levels of BPA exposure in humans, including internal exposures to unconjugated BPA, on the basis that they did not match a model of BPA metabolism. Instead, the EFSA panel relied on two toxicokinetic studies—conducted in 15 adults administered BPA—to draw conclusions about exposure levels in the population, including exposures of neonates.ConclusionsAs with all exposure assessments, models should be developed to explain actual data that are collected. In the case of BPA, samples from a large number of human subjects clearly indicate that humans are internally exposed to unconjugated BPA. The dismissal of these biomonitoring studies simply because their results do not conform to a model violates scientific principles. Expert panels should evaluate all data—including human biomonitoring studies—to make informed risk assessments.
Newer Chemical Diagnostic Tests
Authors: Maurice Bell
Journal: JAMA (1968)

Undoubtedly, one of the most striking advances in the diagnosis and treatment of tumors in children in the last ten years has been the association of the excretion of catecholamines and metabolites in urine with neuroblastoma. These investigations were initiated by the report of increased excretion of pressor amines by Mason and his co-workers<sup>12</sup>in 1957 followed by numerous reports in which a whole spectrum of metabolites was investigated (for summary, see Bell<sup>13</sup>). The materials of major interest in the diagnosis of neuroblastoma are illustrated in Fig 1, although in normal adrenal tissue, the pathway is extended beyond norepinephrine to epinephrine. In the majority of cases of neuroblastoma, the pathways noradrenaline to VMA and dopamine to HVA appear to be the most important, but in a minority, the transamination pathway from 4-hydroxy-3-methoxy-phenylalanine (HMPA) to 4-hydroxy-3-methoxyphenyl lactic acid (HMPLA) and HVA is of greater significance.<sup>14</sup> <h3>Problems of Differential</h3>
Associations Between Diabetes, Leanness, and the Risk of Death in the Japanese General Population
Authors: Yuichiro Yano, Kazuomi Kario, Shizukiyo Ishikawa, Toshiyuki Ojima, Tadao Gotoh, Kazunori Kayaba, Akizumi Tsutsumi, Kazuyuki Shimada, Yosikazu Nakamura, Eiji Kajii
Journal: Diabetes Care (2012)

To examine the BMI-stratified associations between diabetes and the risks of all-cause death, cardiovascular disease (CVD) death, and cancer death.Using a prospective study with 12 rural Japanese general populations (n = 3,641, mean age, 53.7 years; 33.5% men), we examined the associations between diabetes and the risk of all-cause death, CVD death, and cancer death. We also examined the effects of BMI and age on such associations.During an average duration of 10.2 years (37,278 person-years), 240 deaths occurred (54 deaths from CVD, 101 from cancer, and 85 from other causes). Cox regression analysis showed leanness (defined as the lowest quartile of entire BMI; mean, 19.5 kg/m(2)), but not obesity (BMI ≥25 kg/m(2)), and diabetes were independently associated with an increased risk of all-cause death (hazard ratio [HR] 1.70 and 1.65, respectively; both P < 0.01.). Stratification with cause-specific deaths showed that leanness and obesity were associated with CVD death (HR 3.77 and 2.94, respectively), whereas diabetes was associated with cancer death (HR 1.87; all P < 0.05). The increased risk of all-cause death in diabetes was substantially higher in lean subjects aged <65 years (HR 3.4) or those aged ≥65 years (HR 4.2), whereas the risk in obese diabetes patients was significant only in subjects aged <65 years (HR 2.32; all P < 0.05).Among the Japanese general population, diabetes confers an increased risk of all-cause death. Particular attention must be paid to the pronounced high mortality in diabetes accompanied with leanness, regardless of age.
Severe Sepsis and Therapy with Activated Protein C
Authors: Joseph E. Parrillo
Journal: New England Journal of Medicine (2005)

Sepsis, severe sepsis, and septic shock represent a spectrum of increasingly severe diseases that result from serious infection and the body's response to microbiologic invasion. Population data suggest that 750,000 cases of severe sepsis occur in the United States annually; this illness is responsible for as many deaths as acute myocardial infarction (215,000, or 9.3 percent of deaths from all causes).13 Almost every discipline in medicine must deal with this disease, from neonatology to orthopedic surgery to emergency medicine, though much of the management is performed by critical care physicians in intensive care units.The pathogenic mechanisms underlying severe . . .
A piece of my mind. Social ... Security
Authors: A. O. Goldstein
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dietary Zinc and Prostate Cancer Risk: A Case-Control Study from Italy
Authors: Silvano Gallus, Roberto Foschi, Eva Negri, Renato Talamini, Silvia Franceschi, Maurizio Montella, Valerio Ramazzotti, Alessandra Tavani, Luigino Dal Maso, Carlo La Vecchia
Journal: European Urology (2007)
Silencing of HSP90 Cochaperone AHA1 Expression Decreases Client Protein Activation and Increases Cellular Sensitivity to the HSP90 Inhibitor 17-Allylamino-17-Demethoxygeldanamycin
Authors: Joanna L. Holmes, Swee Y. Sharp, Steve Hobbs, Paul Workman
Journal: Cancer Research (2008)

Abstract AHA1 (activator of HSP90 ATPase) is a cochaperone of the ATP-dependent molecular chaperone, HSP90, which is involved in the maturation, stabilization/degradation, and function of oncogenic proteins. HSP90 operates in a multimeric complex driven by the binding and hydrolysis of ATP. Treatment of cells with the HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG) results in the degradation of client proteins via the ubiquitin-proteasome pathway. As AHA1 increases the ATPase activity of HSP90, we hypothesized that modulation of AHA1 expression could influence the activity of client proteins and/or the cellular response to 17-AAG. We show that the basal expression of AHA1 is different across a panel of human cancer cell lines, and that treatment with 17-AAG resulted in sustained AHA1 up-regulation. Increasing the expression of AHA1 did not affect the sensitivity to 17-AAG, but did increase C-RAF activity and the levels of phosphorylated MEK1/2 and ERK1/2 without affecting total levels of these proteins or of client proteins C-RAF, ERBB2, or CDK4. Conversely, small interfering RNA–selective knockdown of &amp;gt;80% of AHA1 expression decreased C-RAF activity and reduced the levels of MEK1/2 and ERK1/2 phosphorylation. Moreover, the AHA1 knockdown resulted in a significant (P &amp;lt; 0.05) increase in sensitivity to 17-AAG, due in part to a 2- to 3-fold increase in apoptosis. These results show that the reduction of AHA1 levels could decrease the phosphorylation of key signal transduction proteins, and for the first time, separate the activation and stabilization functions of HSP90. Furthermore, AHA1 knockdown could sensitize cancer cells to 17-AAG. We conclude that modulation of AHA1 might be a potential therapeutic strategy to increase sensitivity to HSP90 inhibitors. [Cancer Res 2008;68(4):1187–97]
Loss of Stat1 decreases megakaryopoiesis and favors erythropoiesis in a JAK2-V617F–driven mouse model of MPNs
Authors: Adrian Duek, Pontus Lundberg, Takafumi Shimizu, Jean Grisouard, Axel Karow, Lucia Kubovcakova, Hui Hao-Shen, Stephan Dirnhofer, Radek C. Skoda
Journal: Blood (2014)
Immune responses against the mutated region of cytoplasmatic NPM1 might contribute to the favorable clinical outcome of AML patients with NPM1 mutations (NPM1mut)
Authors: Jochen Greiner, Vanessa Schneider, Michael Schmitt, Marlies Götz, Konstanze Döhner, Markus Wiesneth, Hartmut Döhner, Susanne Hofmann
Journal: Blood (2013)
Phrenic and diaphragm function after coronary artery bypass grafting.
Authors: M Estenne, J C Yernault, J M De Smet, A De Troyer
Journal: Thorax (1985)

We studied respiratory mechanics and phrenic nerve and diaphragm function in 12 patients on the day before and eight to 13 days after coronary artery bypass grafting. The average vital capacity, functional residual capacity, and total lung capacity decreased by 20.5%, 9.5%, and 14.7% respectively after operation. Eleven patients showed less negative maximum inspiratory mouth pressures at any given lung volume after surgery and the magnitude of the change correlated with the reduction in total lung capacity. In 11 of the 12 patients the conduction times of the right and left phrenic nerves did not change substantially after operation and the ratio of inspiratory electrical activity (Edi) of left and right hemidiaphragms was similar before and after the procedure. One patient, however, showed a considerable increase in left phrenic nerve conduction time and a reduction in the left to right Edi ratio postoperatively. In three patients diaphragm function was also assessed by changes in transdiaphragmatic pressure during supramaximal phrenic nerve stimulation and voluntary increase in inspired volume; in none of the three patients did the transdiaphragmatic pressure swings show any significant change in the postoperative period. These data indicate that phrenic nerve paralysis only occasionally accounts for the postoperative loss of lung volume after coronary artery bypass grafting surgery. The mechanism of these abnormalities therefore remains to be determined.
Persistent Renal Failure Following Methoxyflurane Anaesthesia.
Authors: D. Churchill
Journal: Annals of Internal Medicine (1973)

Meeting Abstracts1 May 1973Persistent Renal Failure Following Methoxyflurane Anaesthesia.D. Churchill, M.D., M. H. Gault, M.D., F.A.C.P., J. Knaack, M.D., C. Cole, M.D., F.A.C.P., R. C. Muehrcke, M.D., F.A.C.P.D. Churchill, M.D.Search for more papers by this author, M. H. Gault, M.D., F.A.C.P.Search for more papers by this author, J. Knaack, M.D.Search for more papers by this author, C. Cole, M.D., F.A.C.P.Search for more papers by this author, R. C. Muehrcke, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-5-827_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPersistent renal dysfunction followed methoxyflurane anaesthesia in 2 patients. Each was elderly and had received 0.2% methoxyflurane for slightly longer than 4 hours. One developed polyuria, hypernatremia, and azotemia, postoperatively. Serum creatinine rose from 0.9 mg/100 ml, preoperatively, to a peak value of 2.9 mg/100 ml on the 8th postoperative day. Ffteen months after surgery the 24-hr creatinine clearance averaged 36 ml/ min, and maximum osmolality was 424 mosmol/kg of water after dehydration and vasopressin, The second patient had a slow rise in serum creatinine from 1.1 mg/100 ml before surgery to a peak value of 7.5 mg/100 ml on... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Montreal, Quebec, and Oak Park, Illinois. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1973Volume 78, Issue 5Page: 827-827KeywordsCreatinineElderlyHypernatremiaRenal failureSurgeryVasopressin Issue Published: 1 May 1973 PDF DownloadLoading ...
Collaboration between medical and veterinary professions on the problem of dog bites
Authors: C. J. Mannion, K. Shepherd, D. Greenberg
Journal: BMJ (2014)

Orritt’s article highlights the inaccurate use of statistics and reporting of dog bite injuries,1 yet a serious clinical problem exists.2

As a surgeon, one of us (CJM) regularly treats patients with wounds caused by dog bites. Any GP or emergency department doctor is likely to say the same. Increasing numbers of veterinary surgeons are also being bitten and injured.

Clearly, research is needed to establish accurate dog …
Actinomycotic Cerebral Abscess
Authors: Paul Teng
Journal: JAMA (1961)

THE INCIDENCE of cerebral actinomycosis is infrequent. In a few clinical reports found in the literature, it has been often bracketed with cerebral nocardiosis because of their many clinical similarities. Yet, these 2 are distinctly separate diseases. They differ from each other as both from tuberculosis. Prior to the advent of chemotherapy and antibiotic therapy, cerebral infection by Actinomyces bovis was invariably fatal. Since 1949, 9 survived cases of antinomycotic brain abscess, including the 2 of this report, have been recorded in the literature. 1,2,3,5,6,9   The present communication concerns a report of 2 instances of actinomycotic brain abscess and a review of literature, with particular reference to the selection of antibiotics in the treatment of this condition.  Report of Cases  Case 1.—  A 45-year-old, right-handed grocery clerk was admitted to the hospital on Aug. 10, 1958, with a history of frontal headache, dizziness, unsteady gait, and difficulty in speech
Nimesulide, Thrombocytopenic Purpura, and Human Immunodeficiency Virus (HIV) Infection
Authors: M.B. Pasticci, F. Menichetti, F. Di Candilo
Journal: Annals of Internal Medicine (1990)

Letters and Corrections1 February 1990Nimesulide, Thrombocytopenic Purpura, and Human Immunodeficiency Virus (HIV) InfectionM.B. Pasticci, MD, F. Menichetti, MD, F. Di Candilo, MDM.B. Pasticci, MDSearch for more papers by this author, F. Menichetti, MDSearch for more papers by this author, F. Di Candilo, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-112-3-233_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:A 29-year-old man has been followed since 1987 at the Infectious Diseases Institute for a HIV infection contracted by intravenous drug abuse. His hematology values were always within the normal range, with the exception of a slight decrease of CD4 lymphocytes (0.478 X 109/L). His follow-up was uneventful until April 1989 when the patient developed purpuric lesions on the legs after 2 days of nimesulide therapy. When the drug was withdrawn, the lesions subsided completely. Two months later the patient was hospitalized at the Infectious Diseases Institute because of thrombocytopenic purpura. At admission, he had purpuric lesions...References1. MorrisDistenfeldAmorosiKarpatkin LAES. Autoimmune thrombocytopenic purpura in homosexual men. Ann Intern Med. 1982;96:714-8. LinkGoogle Scholar2. Von dem BorneHeimerhorstVan LeeuwenPegelsVon RieszEngelfriet AFEHEC. Autoimmune thrombocytopenia: detection of platelet autoantibodies with the suspension immunofluorescence test. Br J Haematol. 1980;45:319-27. CrossrefMedlineGoogle Scholar3. DeykinHellerstein DL. The assessment of drug-dependent and isoimmune antiplatelet antibodies by the use of platelet aggregometry. J Clin Invest. 1972;51:3142-53. CrossrefMedlineGoogle Scholar4. HackettKeltonPowers TJP. Drug-induced platelet destruction. Semin Thromb Hemostas. 1982;8:116-37. CrossrefMedlineGoogle Scholar5. BiscariniPatoiaDel Favero LLA. Nimesulide. Drugs of Today. 1988;24:23-7. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByNimesulideReview Nimesulide: Some Pharmaceutical and Pharmacological Aspects—An UpdateNimesulideAnti-inflammatory analgesics and drugs used in rheumatoid arthritis and gout 1 February 1990Volume 112, Issue 3Page: 233-234KeywordsDrug abuseDrugsHIVHIV infectionsHematology and oncologyInfectious diseasesLesionsLymphocytes Issue Published: 1 February 1990 PDF DownloadLoading ...
Experts Debate Merits of 1-Day Opiate Detoxification Under Anesthesia
Authors: Joan Stephenson
Journal: JAMA (1997)

AT 7 AM on a Monday morning last fall, a 41-year-old Philadelphia man arrived at a private clinic in a nearby New Jersey town for a controversial treatment that he hoped would help him uproot a 20-year-old opiate addiction. Previous attempts to kick his narcotic habit had been unsuccessful because the misery of withdrawal-related symptoms and ceaseless drug craving posed insurmountable obstacles, he said. But what drew him and hundreds of others to the Merchantville, NJ, clinic was the allure of what some centers have touted as virtually painless opiate detoxification achieved in hours rather than days or weeks. The basic approach, which builds on studies carried out during the past 2 decades, involves administering an opiate antagonist such as naloxone hydrochloride or naltrexone hydrochloride to displace heroin or other narcotics from a patient's opiate receptors. Various combinations of other drugs, such as clonidine hydrochloride, ondansetron hydrochloride, and somatostatin, are