tbuckley/cabot-search huggingface dataset:
The Long-Term Prognosis Following Myocardial Infarction, and Some Factors which Affect It
Authors: DAVID R. COLE, EVELYN B. SINGIAN, LOUIS N. KATZ
Journal: Circulation (1954)

This study was undertaken to establish the long-term prognosis of the initial attack of myocardial infarction. For this purpose, 285 patients who had their initial attack between 1932 and 1942, and who survived the first two months, were followed until their demise or the end of the study (Jan. 1, 1952). Two-thirds of them were found to have lived over 5 years, two-fifths over 10 years and one-tenth over 15 years. Some of the factors which determine long-term survival were analyzed. The importance of recognizing the presence of a large group of mild cases of myocardial infarction capable of long-term survival is stressed.
Trauma to the urinary tract.
Authors: J P Mitchell
Journal: BMJ (1971)

Trauma to thc urinary tract is so large a subject that trauma to each part, even the ureter alone, could present enough interest for a full lecturc.To deal with the whole tract in one lecturc inevitably means that only certain aspects can be considered, and this prescntation today is thereforc in no way a comprehensivc survey. Two PrinciplesThe two principles I wish to discuss are, firstly, the more conservative approach that has developed towards injury of all parts of the urinary tract ovcr the past 20 to 30 ycars, and, secondly, the progress towards a more logical modc of diagnosis and treatment.As regards the morc conservative approach to the kidncy, for examplc, nephrectomy today is a rare operation for trauma.Similarly, in the case of bladdcr and urethral injuries the patient does not have to be rushed to the operating theatre within minutes of the diagnosis being madec bccause of fcar of extravasated urine.Even the uretcr, which may occasionally be the victim of iatrogenic damage, can bc successfully rcanasto- mosed cithcr to its lower end or to another part of the bladder, and no longer does the gynaccologist, having cut the ureter, satisfy himself with tying off this duct deliberatcly, assuming the patient's other kidney to be in satisfactory condition.
Co‐inheritance of Hb Pak Num Po, a novel α1 gene mutation, and α<sup>0</sup> thalassemia associated with transfusion‐dependent Hb H disease
Authors: Vip Viprakasit, Voravarn S. Tanphaichitr, Gavivann Veerakul, Worrawut Chinchang, Siripan Petrarat, Parichat Pung‐Amritt, Douglas R. Higgs
Journal: American Journal of Hematology (2004)

Hb H disease is generally associated with moderate to severe anemia but rarely requires regular blood transfusion. We recently studied two apparently unrelated patients with transfusion-dependent Hb H disease. Hemoglobin studies demonstrated Hb H and Hb Bart's without other detectable abnormal globin species. Extensive molecular analyses of the alpha globin genes and their regulatory sequence (HS-40) revealed that both patients are compound heterozygotes for alpha0 thalassemia (--(SEA)) and a novel point mutation, a thymidine insertion after codon 131 of the alpha1 gene. The resulting frameshift gives rise to a highly unstable alpha globin chain, which we refer to as "Hb Pak Num Po," containing an additional 34 amino acids. This unusual alpha1 globin variant clearly causes alpha thalassemia, but the unexpectedly severe phenotype suggests that this mutation may have additional effects on red cell physiology. A PCR-based (ARMS) assay was developed for rapid detection of this novel mutation, and this might be useful to study the prevalence of this novel mutation which poses potentially significant clinical consequences in populations of Southeast Asia. Detecting carriers of this mutation using the molecular diagnostic procedures described will provide the means to screen and prevent a potentially severe form of alpha thalassemia in Thailand.
Monarticular rheumatoid-like arthritis of seven years' duration following fracture of the radial head
Authors: J. Currey, L H K Therkildsen, E G L Bywaters
Journal: Annals of the Rheumatic Diseases (1986)

AbstractWe report a patient who developed rheumatoid-like arthritis in an elbow joint following a fracture. The arthritis has remained localised to that joint for seven years.
Etiology of the negative chronotropic responses to transient coronary artery occlusion in the anesthetized rhesus monkey.
Authors: W A Alter, R N Hawkins, D E Evans
Journal: Circulation (1978)

Etiology of the negative chronotropic response to coronary artery occlusion was studied in chloralose-anesthetized monkeys. One-minute occlusion of the circumflex (CIRC) coronary artery resulted in marked negative chronotropic responses and consistent alterations in atrial electrograms. These responses were dependent on interruption of flow to a small proximal CIRC branch, and postmortem examination revealed that it perfused the sinus node region. The negative chronotropic response was not dependent on any apparent neural reflexes because it was not affected by autonomic blockade. Coronary artery occlusion in anesthetized monkeys can result in significant decreases in heart rate and changes in atrial electrical activity when flow to the pacemaker region is interrupted. We suggest that (1) rhesus monkeys may be suitable for study of the sick sinus syndrome, and (2) atropine-resistant bradycardia and atrial arrhythmias observed in postinfarction patients may be due to sinus node artery blockade.
Abnormalities of nasal potential difference measurement in Liddle's syndrome.
Authors: E Baker, X Jeunemaitre, A J Portal, P Grimbert, N Markandu, A Persu, P Corvol, G MacGregor
Journal: Journal of Clinical Investigation (1998)

In Liddle's syndrome, a rare inherited form of hypertension, epithelial sodium channel mutations appear to cause high blood pressure by increasing sodium reabsorption through sodium channels in the renal distal tubule. This increase in channel activity has not been confirmed previously by in vivo measurement. We have made transnasal potential difference measurements (effective in detection of increased sodium channel activity in cystic fibrosis) in three brothers with genetically proven Liddle's syndrome, their unaffected sister, and 40 normotensive controls. Maximum potential difference after 2 wk off treatment in the affected brothers was -30.4+/-1.2 mV (values mean+/-SD, lumen-negative with respect to submucosa) and was significantly more lumen-negative than that of the control group (-18.6+/-6.8 mV, P = 0.0228) or the unaffected sister (-18.25 mV, P < 0.01). The change in potential difference after topical application of 10(-)4 M amiloride was greater in the Liddle's patients, 14.0+/-2.1 mV, than in controls (7.9+/-3.9 mV, P = 0.0126) or the unaffected sister (5.5 mV, P < 0.05). This is the first in vivo demonstration of increased sodium channel activity in Liddle's syndrome. If these results are confirmed in other kindreds with this condition, then nasal potential difference measurements could provide a simple clinical test for Liddle's syndrome.
A Randomized Comparison of Radial-Artery and Saphenous-Vein Coronary Bypass Grafts
Authors: Nimesh D. Desai, Eric A. Cohen, C. David Naylor, Stephen E. Fremes
Journal: New England Journal of Medicine (2004)

In the past decade, the radial artery has frequently been used for coronary bypass surgery despite concern regarding the possibility of graft spasm. Graft patency is a key predictor of long-term survival. We therefore sought to determine the relative patency rate of radial-artery and saphenous-vein grafts in a randomized trial in which we controlled for bias in the selection of patients and vessels.We enrolled 561 patients at 13 centers. The left internal thoracic artery was used to bypass the anterior circulation. The radial-artery graft was randomly assigned to bypass the major vessel in either the inferior (right coronary) territory or the lateral (circumflex) territory, with the saphenous-vein graft used for the opposing territory (control). The primary end point was graft occlusion, determined by angiography 8 to 12 months postoperatively.Angiography was performed at one year in 440 patients: 8.2 percent of radial-artery grafts and 13.6 percent of saphenous-vein grafts were completely occluded (P=0.009). Diffuse narrowing of the graft (the angiographic "string sign") was present in 7.0 percent of radial-artery grafts and only 0.9 percent of saphenous-vein grafts (P=0.001). The absence of severe native-vessel stenosis was associated with an increased risk of occlusion of the radial-artery graft and diffuse narrowing of the graft. Harvesting of the radial artery was well tolerated.Radial-artery grafts are associated with a lower rate of graft occlusion at one year than are saphenous-vein grafts. Because the patency of radial-artery grafts depends on the severity of native-vessel stenosis, such grafts should preferentially be used for target vessels with high-grade lesions.
What (If Anything) Is Wrong with Residency Overwork?
Authors: Michael J. Green
Journal: Annals of Internal Medicine (1995)

Long work hours during residency are a time-honored tradition. Efforts have recently been made to shorten work hours. This paper examines the main arguments supporting reform: that sleep deprivation is harmful to patients and residents and that it is exploitative. Because the data on the harms and benefits are mixed and because exploitation is difficult to prove, a stronger argument for reducing work hours is an ethical one: that overwork interferes with the development of professional values and attitudes that are an essential part of the moral curriculum of residency. Providing a climate that promotes moral growth during training is an important curricular objective that may be better achieved by shortening work hours, providing better resident supervision, and using substitute workers for some of the noneducational tasks of residency.
Primary Aldosteronism with Aldosterone-Producing Adenoma Consisting of Pure Zona Glomerulosa-Type Cells in a Pregnant Woman
Authors: Kazuto Shigematsu, Noriyuki Nishida, Hideki Sakai, Tsukasa Igawa, Shin Suzuki, Kioko Kawai, Osamu Takahara
Journal: Endocrine Pathology (2009)
Handbook of Treatment of Mental Disorders in Childhood and Adolescence
Authors: A. Herbert Schwartz
Journal: JAMA (1978)

A handbook should be small and easy to carry. A handbook of treatment should be concise and specific, telling what to do and when. If these two statements sum up your expectations, then the word "handbook" should be deleted from the title of this book. It is 28×23×5 cm and covers a difficult and confusing field. Twenty-four chapters, ranging from a few to 30 or more pages, provide a thorough description of child and adolescent therapy. The book includes topics such as therapeutic nurseries, speech disorders, and child abuse, as well as the expected ones such as chemotherapy and behavior therapy. The several varieties of treatment for the antisocial child and the psychotic child are given separate chapters. All of the chapters provide a clear presentation of their respective fields. Particularly noteworthy are the sections on behavioral therapy, family therapy, minimal brain dysfunction, and enuresis. The discussions of learning disabilities
Cross sensitivity to antithyroid drugs.
Authors: A. Smith, R. F. Gledhill, P. Jenkins
Journal: BMJ (1989)

Erythromelalgia due to calcium antagonists may be more frequent than reported.It is probably often reported as flushing or paraesthesia of the hands and feet.Doctors prescribing these drugs should be aware of this inverse Raynaud's phenomenon and withdraw the drug(s) before sending their patients for extensive investigations.1
Resident's Guide to Starting in Medical Practice
Authors: Donald L. Madison
Journal: JAMA (1995)

Each year, 17 000 US  graduates and 7000 international  graduates begin residency training in the United States. Three or more years later these physicians will confront another career crossroads. Most will enter some form of practice, after having weighed their options and opportunities to join this or that practice organization, hang out a shingle on their own, or do something else.  This handbook, prepared by physicians in emergency medicine—one is listed as editor, the others are medical contributors, but only the preface has a byline—is an attempt to allay the common complaint [by residents] of never receiving any significant advice or training regarding the nonmedical aspects of starting in  practice after residency. The sheer number of residents coming out every year would suggest that an eager audience might await a handbook with a title like this one. Unfortunately, few of them will find here the information they
Medtronic submits full data on spinal protein to independent scrutiny
Authors: D. Cohen
Journal: BMJ (2011)

The company at the centre of an investigation by a US Senate committee into an alleged failure to mention the side effects of a spinal treatment it makes has agreed to fund an independent review into the safety and effectiveness of the product. It is the first time that a medical technology company has agreed to this type of detailed scrutiny.

Medtronic announced in early August that it will give Yale University $2.5m (£1.5m; €1.7m) to review all published and unpublished data on the safety and effectiveness of Infuse Bone Graft, a recombinant bone morphogenetic protein 2 (rhBMP-2) that is used to stimulate bone growth in spine fusion surgery.

In what the company describes as “unprecedented in the medical industry,” academics will be granted access to full patient data possessed by Medtronic—and not …
Corticosteroids for patients with septic shock. Authors' reply
Authors: Julian M. Brown, Christina L. Schenarts, Juan A. March, Julian Millo, Steven M. Opal, Jan G. Zijlstra, Iwan C. C. Van Der Horst, Jaap E. Tulleken, Tjip S. Van Der Werf, Jack J. M. Ligtenberg, David R. Williamson, Martin Albert, Marco Charneux, Babak Mokhlesi, Djillali Annane, Véronique Sebille, Eric Bellissant
Journal: JAMA (2003)
Evaluation of noninvasive tests of cardiac damage in suspected cardiac contusion.
Authors: R T Potkin, J A Werner, G B Trobaugh, C H Chestnut, C J Carrico, A Hallstrom, L A Cobb
Journal: Circulation (1982)

Nonpenetrating trauma to the chest can result in cardiac damage that may be overlooked because of associated injuries and the lack of obvious thoracic injury. The clinical diagnosis of important cardiac damage in this setting is difficult. We evaluated noninvasive tests for detecting myocardial damage in 100 patients with severe, nonpenetrating chest trauma. The noninvasive tests included serial ECG, serial total CPK and CPK-MB enzymes, continuous Holter monitor recording to detect dysrhythmia, and technetium-99m pyrophosphate scintigraphy. Peak CPK-MB elevations occurred in 72 patients. ECG abnormalities were noted in 70 patients, and 27 patients had Lown grade 3 or greater dysrhythmias. Fifteen patients died and all had autopsies. The noninvasive abnormalities were nonspecific and did not reflect myocardial contusion that led to clinically important cardiac complications.
Christmas Disease Associated with Factor VII Deficiency
Authors: W. N. Bell, H. G. Alton
Journal: BMJ (1955)

BMMD H complained of indigestion, but, on questioning, he said he was " a martyr to attacks of indigestion."Case T found that his rheumatic pains, for which he had had many medical remedies, cleared " miraculously " while he was under treat- ment, but they returned as soon as the treatment was stopped.The patients who were under observation for less than six months were asked to communicate with us should there be a relapse, but as yet we have had no response.Two cases of subacute disseminated lupus erythematosus were also treated with chloroquine sulphate with no satisfactory clinical response. Summary and ConclusionsEighteen cases of chronic discoid lupus erythematosus were treated with chloroquine sulphate by mouth.The results are tabulated and discussed.It is considered that chloroquine sulphate is as effi- cient a form of palliative therapy as any previously used, though not as yet the answer for the chronic disease.There is still a place for CO2 snow treatment where there is a single discoid lesion.I have to thank Dr. Alice Carleton, consulting dermatologist, the Radcliffe Infirmary, Oxford, for
Two types of febrile seizure: anoxic (syncopal) and epileptic mechanisms differentiated by oculocardiac reflex
Authors: J B P Stephenson
Journal: BMJ (1978)

The duration of cardiac asystole induced by ocular compression was measured in 100 consecutive children referred for electroencephalographic examination after one or more febrile convulsions (FC). The children were classified into three groups-namely, those with anoxic FCs, those with epileptic FCs, and "others"-according to the appearances of the FC and the electroencephalogram (EEG). In 14 children the description of the FC suggested non-epileptic anoxic cerebral seizures such as are seen after prolonged syncope or breath-holding. In 35 children the FCs were assumed to be epileptic in mechanism on the basis of unilateral (hemiclonic) twitching, known cerebral disease, a family history of epilepsy, or spikes on the EEG. In the 51 "others" the FCs could not be classified. Definitely abnormal asystole (four seconds or over) was induced by ocular compression in half the anoxic group, in 16% of the "others," but in none of the epileptic group. The differences between the degree of asystole induced in each of the three groups was highly significant (P=0.005).These results support the hypothesis that vagal-mediated cerebral ischaemic anoxia is implicated in the genesis of FCs that resemble anoxic seizures and in a substantial number of those without an obvious epileptic mechanism. The significance, genetics, management, and prognosis of FCs must now be re-examined in this light.
Impact of primary biliary cirrhosis on perceived quality of life: The UK-PBC national study
Authors: George F. Mells, Greta Pells, Julia L. Newton, Andrew J. Bathgate, Andrew K. Burroughs, Michael A. Heneghan, James M. Neuberger, Darren B. Day, Samantha J. Ducker, Richard N. Sandford, Graeme J. Alexander, David E.J. Jones
Journal: Hepatology (2013)

Abstract Primary biliary cirrhosis (PBC) has a complex clinical phenotype, with debate about the extent and specificity of frequently described systemic symptoms such as fatigue. The aim of this study was to use a national patient cohort of 2,353 patients recruited from all clinical centers in the UK to explore the impact of disease on perceived life quality. Clinical data regarding diagnosis, therapy, and biochemical status were collected and have been reported previously. Detailed symptom phenotyping using recognized and validated symptom assessment tools including the PBC-40 was also undertaken and is reported here. Perception of poor quality of life and impaired health status was common in PBC patients (35% and 46%, respectively) and more common than in an age-matched and sex-matched community control group (6% and 15%, P &lt; 0.0001 for both). Fatigue and symptoms of social dysfunction were associated with impaired perceived quality of life using multivariate analysis. Fatigue was the symptom with the greatest impact. Depression was a significant factor, but appeared to be a manifestation of complex symptom burden rather than a primary event. Fatigue had its greatest impact on perceived quality of life when accompanied by symptoms of social dysfunction, suggesting that maintenance of social networks is critical for minimizing the impact of fatigue. Conclusion : The symptom burden in PBC, which is unrelated to disease severity or ursodeoxycholic acid response, is significant and complex and results in significant quality of life deficit. The complexity of symptom burden, and its lack of relation to disease severity and treatment response, suggest that specific approaches to symptom management are warranted that address both symptom biology and social impact. (Hepatology 2013;58:-)
Episodic Rage Associated with Primary Aldosteronism Resolved with Adrenalectomy
Authors: David J. Houlihan
Journal: Psychotherapy and Psychosomatics (2011)

Letters| June 30 2011 Episodic Rage Associated with Primary Aldosteronism Resolved with Adrenalectomy Subject Area: Psychiatry and Psychology David J. Houlihan David J. Houlihan Veterans Affairs Medical Center, Tomah, Wisc., USA Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (2011) 80 (5): 306–307. https://doi.org/10.1159/000323618 Article history Received: November 29 2010 Accepted: December 15 2010 Published Online: June 30 2011 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation David J. Houlihan; Episodic Rage Associated with Primary Aldosteronism Resolved with Adrenalectomy. Psychother Psychosom 1 July 2011; 80 (5): 306–307. https://doi.org/10.1159/000323618 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search This content is only available via PDF. © 2010 S. Karger AG, Basel2011Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Article PDF first page preview Close Modal You do not currently have access to this content.