tbuckley/cabot-search huggingface dataset:
IMPACT OF IRS-1 GENOTYPES ON PLATELET REACTIVITY AND CARDIOVASCULAR OUTCOMES IN TYPE 2 DIABETES MELLITUS PATIENTS WITH CORONARY ARTERY DISEASE
Authors: Dominick Angiolillo, Esther Bernardo, Martina Zanoni, Piera Capranzano, Giovanni Malerba, Elisabetta Trabetti, Manel Sabate’, Pilar-Jimenez Quevedo, Paola Prandini, Davide Capodanno, Jose’ Luis Ferreiro, Theodore Bass, Pier Franco Pignatti, Antonio Fernandez-Ortiz, Carlos Macaya
Journal: Journal of the American College of Cardiology (2010)
1013 CD163 IS A MECHANISTIC BIOMARKER IN ACUTE LIVER FAILURE REFLECTING A MACROPHAGE ACTIVATION LIKE SYNDROME
Authors: C. Antoniades, E. Triantafyllou, R. Gadhok, R. Abeles, A. Quaglia, W. Khamri, R. Tidswell, M. McPhail, L. Possamai, W. Bernal, M. Heneghan, Y. Ma, G. Auzinger, N. Heaton, M. Thursz, J. Wendon
Journal: Journal of Hepatology (2013)
Haemodialysis in glutethimide poisoning.
Authors: B. Hickson, D. T. Caridis
Journal: BMJ (1969)

June, p. 820) reflect the feelings of many engaged in neonatal care.However, I feel they have not carried their simplification quite far enough.At the moment I am undertaking a large series to compare the Apgar score with a score deduced from only the breathing and heart rate.
OUTCOMES AFTER REPEAT PERCUTANEOUS CORONARY INTERVENTION WITH EVEROLIMUS-ELUTING STENT FOR SIROLIMUS-ELUTING STENT RESTENOSIS LESION WITH STENT FRACTURE
Authors: Yasunari Sakamoto, Toshiya Muramatsu, Reiko Tsukahara, Yoshiaki Ito, Hiroshi Ishimori, keisuke hirano, Masatsugu Nakano, Masahiro Yamawaki, Motoharu Araki
Journal: Journal of the American College of Cardiology (2014)
p53 Mutations in nonmalignant human liver: Fingerprints of aflatoxins?
Authors: Mehmet Ozturk
Journal: Hepatology (1995)

Fifty-eight percent of hepatocellular carcinomas (HCCs) from Qidong, China, contain an AGG to AGT mutation at codon 249 of the p53 tumor suppressor gene, a mutation that is rarely seen in HCCs from Western countries. The population of Qidong is exposed to high levels of aflatoxin B 1 (AFB 1 ), a fungal toxin that has been shown to induce the same mutation in cultured human HCC cells. To investigate the role of AFB 1 and of these p53 mutations in hepatocarcinogenesis, normal liver samples from the United States, Thailand, and Qidong (where AFB 1 exposures are negligible, low, and high, respectively) were examined for p53 mutations. The frequency of the AGG to AGT mutation at codon 249 paralleled the level of AFB 1 exposure, which supports the hypothesis that this toxin has a causative—and probably early—role in hepatocarcinogenesis.
Features of small intestinal pathology (epithelial cell kinetics, intraepithelial lymphocytes, disaccharidases) in a primary Giardia muris infection.
Authors: J Gillon, D Al Thamery, A Ferguson
Journal: Gut (1982)

In an attempt to correlate host and parasite-related events occurring during the course of a primary Giardia infection in the mouse we have measured epithelial cell kinetics, enzymes, and intraepithelial lymphocytes at different stages of the infection. New methods were developed for the accurate measurement of parasite numbers and distribution within the gut. In jejunum a modest decrease in villus length and intraepithelial lymphocytes at week 1 preceded a pronounced disaccharidase deficiency at week 2, the time of maximum trophozoite numbers, whereas crypt lengthening and increased cell production became maximal at week 3. As trophozoite numbers fell the intraepithelial lymphocyte count and disaccharidase values rose. With the exception of the intraepithelial lymphocyte count, which followed the same pattern as in jejunum but two weeks later, the changes seen in the ileum were the opposite of those in jejunum, suggesting rapid ileal adaptation. The results indicate that the disaccharidase deficiency associated with giardiasis is likely to represent a direct effect of the parasite on the brush border rather than enterocyte immaturity, whereas the intraepithelial lymphocyte response reflects host immunity to the parasite. Profound adaptive changes occur throughout the small intestine in response to a relatively localised insult.
The Value of Corticosteroids in the Treatment of Infectious Mononucleosis
Authors: Charles E. Bender
Journal: JAMA (1967)

Corticotropin or prednisolone was used to treat 66 students who had severe but uncomplicated mononucleosis, after it was clinically apparent that the illness was worsening under conservative management. Treated patients included those with anginose, typhoidal, and hepatic syndromes. Duration of fever after starting treatment was used to assess the drug effect. Each treated patient was matched with an untreated patient which resulted in 66 pairs of patients having minimal biologic variations as well as very similar clinical syndromes and fever ranges. A comparison of the febrile periods in the matched pairs showed an average period of 5.6 days for the untreated group and 1.4 days for the treated group. The difference, 4.2 days, was highly significant.
13 POTENTIAL NEGATIVE IMPACT OF AGING ON HEPATOCARCINOGENESIS AFTER ANTI-VIRAL TREATMENT IN PATIENTS WITH CHRONIC HEPATITIS C AND BENEFIT OF VIRAL ERADICATION BY PEG-INTERFRON/RIBAVIRIN TREATMENT
Authors: Y. Asahina, N. Izuni, I. Hirayama, M. Sato, Y. Yasui, T. Tanaka, N. Komatsu, N. Umeda, T. Hosokawa, K. Ueda, K. Tsuchiya, H. Nakanishi, J. Itakura, M. Kurosaki, S. Miyake
Journal: Journal of Hepatology (2008)
Increased Mammary Uptake on 111In Pentetreotide Scintigraphy
Authors: Stoffel F. J. Van Eeckhoudt, Jaap J. M. Teunissen, Dik J. Kwekkeboom
Journal: Clinical Nuclear Medicine (2012)

The normal scintigraphic features of 111In pentetreotide include uptake in the pituitary, thyroid, liver, spleen, kidneys, urinary bladder, gallbladder, and bowel. In premenopausal women, faint activity can be seen in the breasts. We present 2 cases of symmetrical, markedly increased mammary uptake. Our hypothesis to explain this pattern of uptake is an upregulation of the somatostatin type 2 receptor caused by high blood levels of estradiol during pregnancy. Estradiol levels during the menstrual cycle could therefore explain the variable degree of uptake commonly seen in premenopausal women.
The expression of RAGE and EN-RAGE in leprosy
Authors: M-H. Kim, Y.W. Choi, H.Y. Choi, K.B. Myung, S.N. Cho
Journal: British Journal of Dermatology (2006)

Extracellular newly identified RAGE-binding protein (EN-RAGE) is a ligand of the receptor for advanced glycation endproducts (RAGE) and has been termed S100A12. The ligation of EN-RAGE with RAGE on the endothelium, mononuclear phagocytes and lymphocytes triggers cellular activation with the generation of the key proinflammatory mediators interleukin (IL)-1beta and tumour necrosis factor (TNF)-alpha.The aim of this study was to investigate the presence of RAGE and EN-RAGE, their spatial localization and their coexpression in leprosy lesions.Immunohistochemistry and confocal laser scanning microscopy were used to evaluate the expression of RAGE and EN-RAGE in leprosy. By enzyme-linked immunosorbent assay, RAGE and EN-RAGE were detected in the serum.(1) In the multibacillary (MB) and paucibacillary (PB) groups, the level of RAGE production was significantly higher than in patients with atypical mycobacterial infection or sarcoidosis (P < 0.01). In the MB group, the production of RAGE was higher than in the PB group (P < 0.01), and it was higher in patients without the lepra reaction than in patients with the lepra reaction (P < 0.05). (2) In MB, PB and atypical mycobacterial infection, the level of EN-RAGE production was significantly higher than in sarcoidosis (P < 0.01). (3) In the confocal laser scanning microscopic examination, the RAGE and EN-RAGE proteins were detected in lepromatous leprosy. These proteins are spatially colocalized along the cell surface, which is in agreement with their receptor-ligand interaction. (4) A comparable amount of EN-RAGE was detected in the serum of the MB and PB groups. Patients with the reaction showed a higher level of EN-RAGE than patients without the reaction in leprosy.Our data suggest that in leprosy, RAGE and EN-RAGE may be involved in the proinflammatory process rather than the antimycobacterial activity, especially during the lepra reaction. The blockade of the interaction of RAGE and EN-RAGE at the early stage of the inflammatory process may minimize the inflammatory response and consequent tissue damage or the sequelae of leprosy.
Validation of the Quality of Histological Images Obtained of Fresh and Formalin-Fixed Specimens of Esophageal and Gastric Mucosa by Laser-Scanning Confocal Microscopy
Authors: P. Chiu, H. Inoue, H. Satodate, T. Kazawa, T. Yoshida, M. Sakashita, S. Kudo
Journal: Endoscopy (2006)

Background and Study Aims: We have previously reported the success of a method of virtual histology using laser-scanning confocal microscopy (LCM) in vitro on untreated fresh specimens obtained from the gastrointestinal mucosa. In the present study, we aimed to apply LCM to both fresh and formalin-fixed specimens, without additional treatment, in order to validate and compare the quality of the images obtained. Methods: We obtained 18 specimens from 11 patients, either by endoscopic biopsy or following surgical resection. First, we observed the fresh, saline-immersed specimen with LCM using the Fluroview microscope (Olympus Co. Ltd., Tokyo, Japan). We then fixed the specimen with formalin and obtained further LCM images 1 hour, 3 hours, and 24 hours after fixation. Three independent observers observed the images and were asked to assess the origin of the samples, the treatment of the samples, the time after formalin fixation, and whether they showed benign or malignant lesions. We used kappa statistics to compare the agreement among the three observers in each of these four areas of interest. Results: Between January and March 2003, we obtained 191 LCM images from 18 specimens. Thirty images were randomly selected for observation. The overall accuracy for differentiating between esophagus and stomach specimens was 96.6 %. The accuracy of differentiating normal from cancerous lesions was 92.2 %. The differentiation between saline-immersed and formalin-fixed specimens was 59.7 % accurate and the assessment of the time interval after formalin fixation was only 37.3 % accurate. The kappa statistics showed that there was strong interobserver agreement on the differentiation of specimen origin and of cancerous from benign lesions. However, there was no agreement among the observers on the method of specimen preparation or on the estimated time interval after formalin fixation. Conclusions: We concluded that images obtained from fresh specimens using LCM were of a quality good enough to make an accurate diagnosis of upper gastrointestinal carcinoma.
Phenotyping the effect of diet on non-alcoholic fatty liver disease
Authors: Nicole J.W. de Wit, Lydia A. Afman, Marco Mensink, Michael Müller
Journal: Journal of Hepatology (2012)

Non-alcoholic fatty liver disease (NAFLD) is associated with the growing incidence of metabolic syndrome. Diet is an important contributor to the pathogenesis of NAFLD. In this review, we focused on recent publications reporting on the effect of macro- and micronutrients on development and progression of NAFLD. In general, saturated fat and fructose seem to stimulate hepatic lipid accumulation and progression into NASH, whereas unsaturated fat, choline, antioxidants, and high-protein diets rich in isoflavones seem to have a more preventive effect. Knowledge of the underlying mechanisms by which diet affects NAFLD is expanding, not in the least due to innovative techniques, such as genomics tools that provide detailed comprehensive information on a large high-throughput scale. Although most nutrients seem to interfere with the balance between hepatic de novo lipogenesis (endogenous synthesis of fatty acids) and lipid oxidation (burning fat for energy), there are also indications that diet can trigger or prevent hepatic lipid accumulation by influencing the interaction between liver, gut, and adipose tissue. This review now gives a current detailed overview of diet-mediated mechanisms underlying NAFLD development and progression and summarizes recent results of genomics (transcriptomics, proteomics and metabolomics) studies that contribute to improved staging, monitoring and understanding of NAFLD pathophysiology.
Determinants for sustained HBeAg response to lamivudine therapy
Authors: Rong-Nan Chien, Chau-Ting Yeh, Sun-Lung Tsai, Chia-Ming Chu, Yun-Fan Liaw
Journal: Hepatology (2003)

There are inconsistent data on the durability of hepatitis B e antigen (HBeAg) seroconversion after lamivudine is discontinued. The aim of this study was to examine the determinants for sustained HBeAg response to lamivudine therapy. Both host and viral factors as well as the drug factor were compared between 43 patients with sustained HBeAg response and 39 patients whose response was not sustained. All of them received a mean period of 16 months (range, 3–55 months) lamivudine therapy and had achieved complete response (HBeAg seroconversion plus HBV DNA seroclearance by hybrid capture assay and normal alanine aminotransferase [ALT]) and were followed–up for a mean period of 44 months (range, 12–88 months). Stepwise logistic regression model was used to estimate the sustained response on the presence of the following variables: age; gender; pretherapy ALT; total bilirubin and HBV DNA levels; time to HBeAg seroconversion; additional lamivudine treatment after HBeAg seroconversion; total duration of treatment; hepatitis activity index scores; periportal, intralobular, and portal inflammation and fibrosis scores; scores excluding fibrosis; status of precore mutation; basal core promoter mutation; and genotype. The results showed that genotype (OR, 5.922; 95% CI, 1.611–21.768; P = .007), age (OR, 0.943; 95% CI, 0.891–0.997; P = .040), and additional treatment (OR, 1.097; 95% CI, 1.028–1.171; P = .005) were independent factors to sustained HBeAg response. Further categorical analysis disclosed that patients with genotype B, age ≤36 years, and additional lamivudine treatment over 8 months have higher sustained response. In conclusion, HBV genotype, age, and additional treatment are the major determinants for the sustained HBeAg response to lamivudine therapy.
Extramedullary Acute Myeloid Leukemia and the Use of FDG-PET/CT
Authors: Sonali Rao, Amelia Langston, James R. Galt, Raghuveer K. Halkar
Journal: Clinical Nuclear Medicine (2009)

Extramedullary acute myeloid leukemia (AML) is a leukemic infiltration outside the bone marrow and is common in monocytic and myelomonocytic leukemia. The incidence is rare (0.6%-7.4%) and the clinical diagnosis requires a high index of suspicion. Fluorodeoxyglucose-positron emission tomography (FDG-PET) is used to detect, stage, and restage solid tumors, including lymphomas and Richter transformation. However its role in the management of liquid tumors and specifically in extramedullary AML has not been assessed. We present a case of a 64-year-old man who was diagnosed with AML and subsequently had recurrent extramedullary AML relapses. This case demonstrates the usefulness of FDG-PET for staging and assessment of the treatment response.
Raised cardiac troponins
Authors: Peter Ammann, Matthias Pfisterer, Thomas Fehr, Hans Rickli
Journal: BMJ (2004)

Alcohol abuse by adolescents is widespread in the UK, has complex cultural, economic and biological origins and is associated with adverse health consequences. Affected young people present medically with intoxication or its consequences such as injury, self harm and sometimes physiological dependence. Practitioners have greater capacity to respond effectively than they may believe. Modest concerted effort could make the medical profession much more relevant to the needs of these often troubled youth.
THE AETIOLOGY, PATHOLOGY AND COURSE OF GIANT-CELL ARTERITIS.*.
Authors: P. D. C. KINMONT, D. I. McCALLUM
Journal: British Journal of Dermatology (1965)

Journal Article THE AETIOLOGY, PATHOLOGY AND COURSE OF GIANT‐CELL ARTERITIS.: THE POSSIBLE ROLE OF LIGHT SENSITIVITY. Get access P. D. C. KINMONT, M.B.E., M.D., M.R.C.P., P. D. C. KINMONT, M.B.E., M.D., M.R.C.P. Consultant Dermatologist, Derbyshire Royal Infirmary, Derby Search for other works by this author on: Oxford Academic Google Scholar D. I. McCALLUM, M.C., M.D., D.P.H., F.R.C.P.E. D. I. McCALLUM, M.C., M.D., D.P.H., F.R.C.P.E. Consultant Dermatologist, Nottingham General Hospital, Nottingham Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 77, Issue 4, 1 April 1965, Pages 193–202, https://doi.org/10.1111/j.1365-2133.1965.tb14630.x Published: 01 April 1965
A second case of prothrombin puerto rico I in the united states
Authors: Stephen J. Kling, Kimberly A. Jones, George M. Rodgers
Journal: American Journal of Hematology (2006)

Abstract Prothrombin deficiency is a very rare autosomal recessive bleeding disorder associated with mild to severe bleeding symptoms. We identified this bleeding disorder in a US‐born patient as due to prothrombin Puerto Rico I. Unlike other prothrombin deficiencies, prothrombin Puerto Rico I is a series of concordant polymorphisms found in people of Puerto Rican descent with a much higher frequency than those prothrombin deficiencies found in the general population. This case underscores the importance of family history in identifying rare bleeding disorders. Am. J. Hematol 2007. © 2006 Wiley‐Liss, Inc.
BLOOD LEVELS OF 17-HYDROXYCORTICOSTEROIDS FOLLOWING THE ADMINISTRATION OF ADRENAL STEROIDS AND THEIR RELATION TO LEVELS OF CIRCULATING LEUKOCYTES 1
Authors: Don H. Nelson, Avery A. Sandberg, J. G. Palmer, Frank H. Tyler
Journal: Journal of Clinical Investigation (1952)

occurrence of neutrophilia and lymphopenia following the administration of ACTH or adrenal cortical extracts to mice. In 1948 these findings were confirmed in man by Hills, Forsham and Finch (2), who noted, in addition, a pronounced fall in eosinophils. These changes in the blood have been used widely as an index of adrenal cortical activity. With the development of a method for the determination of 17-hydroxycorticosteroids in small quantities of blood or plasma (3) it has become possible to determine the relationship of the changes in blood steroid levels to the changes in leukocytes. In order to investigate this relationship, standard doses of various corticosteroids were administered to normal individuals and the alterations in blood 17-hydroxycorticosteroids and in leukocytes were observed at intervals thereafter.
Thirteen women die from mass sterilisation in Chhattisgarh
Authors: S. Bagcchi
Journal: BMJ (2014)

The death toll from a government run mass sterilisation programme in the Indian state of Chhattisgarh reached 13 on 12 November, with a further 14 women described as “seriously ill.” 

The deaths triggered outrage across central India, where protesters took to the streets, smashed cars, and asked for the resignation of Raman Singh, the chief minister of Chhattisgarh.1

The sterilisations took place on 8 November in Bilaspur. A 59 year old doctor, R K Gupta, performed laparoscopic sterilisations on 83 women at a mass sterilisation camp held under a government …
Pneumatosis Intestinalis After Jejunoileal Bypass
Authors: René Menguy
Journal: JAMA (1976)

JEJUNOILEAL bypass for gross, morbid obesity has become widely accepted during the past few years. As one would expect from an operation creating major perturbations in the anatomy and physiology of the alimentary tract, the price paid, in terms of undesirable side effects for the often spectacular results, has been high, albeit not prohibitively so. Among the unanticipated and apparently specific complications of this operation that have been discovered recently is that of pneumatosis intestinalis in the bypassed intestine. Two cases have been reported by Passaro et al<sup>1</sup>and one by Martyak and Curtis.<sup>2</sup>All three cases were characterized by severe gaseous distension of the small bowel associated with subserosal air dissection and, in two instances, with pneumoperitoneum. One patient in our series has had this complication, and under circumstances that enabled us to understand the mechanism of its development. If our interpretation is correct, this complication should
Medical audit in general practice.
Authors: M. Lawrence
Journal: BMJ (1992)

different scales are used.In such a case the intraclass correlation coefficient computed for each method will indicate which is the more reliable, provided each method of measurement uses the same population, as in a dataset we recently examined.'In summary, we agree with Chinn when she says that "the intraclass correlation coefficient should be used only for comparative purposes.The within-subject standard deviation or 95 per cent range for change should be calculated as the absolute measure of repeatability."2
THE TESTING OF AGENTS AND METHODS FOR THE TREATMENT OF HYPERTENSION
Authors: Royall M. Calder
Journal: JAMA (1942)

<h3>To the Editor.—</h3> The article entitled "Experimental Observations on the Treatment of Hypertension," by Goldblatt and others (The Journal, August 8) merits amplification. The authors state that "since it is now possible to test the effect of renal extracts [and other therapeutic agents] on experimental hypertension in animals, they should not be made available for general use... until more consistent results have been obtained in many tests on animals with experimental hypertension." It can hardly be disputed that, if a given agent or method is efficacious in the treatment of experimental hypertension in animals, it is at least worth a trial in human medicine; but the converse would be true only if it was established that irreversible arterial and arteriolar sclerosis invariably precedes and determines hypertension in man. In this connection the most that Dr. Goldblatt has ever contended in his writings is that arteriolar sclerosis "probably precedes" and "is
Abstract 421: Dystroglycan glycosylation status predicts Gleason grade and influences prostate tumor growth
Authors: Alison K. Esser, Christine J. Weydert, Melissa M. Meier, Daniel Beltran-Valero de Bernabe, Brian J. Smith, Michael B. Cohen, Kevin P. Campbell, Michael D. Henry
Journal: Cancer Research (2010)

Abstract Dystroglycan, an extracellular matrix receptor, is expressed in many tissues including muscle, neural, adipose and epithelial where its function includes roles in polarity, basement membrane formation and tissue morphogenesis. Loss of dystroglycan expression has been shown in many epithelial cancers including prostate cancer yet the underlying mechanism remains unclear. Here, we investigate the role of DG in prostate cancer progression. We show that staining for the extracellular αDG subunit with the glycosylation-sensitive IIH6 anti-αDG antibody as well as the transmembrane βDG subunit are independent predictors of Gleason score in clinical prostate cancer specimens. In addition, increased αDG glycosylation due to expression of LARGE, a putative glycosyltransferase, in prostate cancer cell lines results in decreased tumor growth in prostate cancer xenografts. We determined that this reduction in growth is specific to the effect of LARGE on dystroglycan. Therefore our work has shown that the extent of αDG glycosylation predicts Gleason scores in prostate cancer and that LARGE dependent glycosylation of αDG regulates tumor growth. This work is supported by a grant from the National Institutes of Health R01-CA130916 Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 421.
Comparison of the 24-Hour Intraocular Pressure–Lowering Effects of Latanoprost and Dorzolamide/Timolol Fixed Combination after 2 and 6 Months of Treatment
Authors: Anastasios G.P. Konstas, Vassilios P. Kozobolis, Sevasti Tsironi, Irene Makridaki, Rallitsa Efremova, William C. Stewart
Journal: Ophthalmology (2008)