Reversible Cardiomyopathy Associated with Cocaine Intoxication
Authors: Saurabh K. Chokshi
Journal: Annals of Internal Medicine (1989)

Brief Reports15 December 1989Reversible Cardiomyopathy Associated with Cocaine IntoxicationSaurabh K. Chokshi, MD, Richard Moore, MD, Natesa G. Pandian, MD, Jeffrey M. Isner, MDSaurabh K. Chokshi, MD, Richard Moore, MD, Natesa G. Pandian, MD, Jeffrey M. Isner, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-111-12-1039 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCocaine intoxication typically produces a profoundly enhanced sympathomimetic state and has been temporally associated with various serious, including fatal, medical disorders. Chief among these disorders are cardiovascular complications, principally acute myocardial infarction (1). Dilated cardiomyopathy has been reported only rarely in association with cocaine abuse (2, 3). We describe a patient who developed an acutely dilated cardiomyopathy temporally related to smoking ("free-basing") the "crack" formulation of cocaine. Over 2 weeks, however, serial noninvasive studies showed reversal of her cardiomyopathy with a marked improvement in left ventricular systolic function. This patient's course was similar to that of patients with reversible catecholamine...References1. IsnerEstesThompson JMP. Acute cardiac events temporally related to cocaine abuse. N Engl J Med. 1986;315:1438-43. CrossrefMedlineGoogle Scholar2. WienerLockhartSchwartz RJR. Dilated cardiomyopathy and cocaine abuse: report of two cases. Am J Med. 1986;81:699-701. CrossrefMedlineGoogle Scholar3. Duell P. Chronic cocaine abuse and dilated cardiomyopathy [Letter]. Am J Med. 1987;83:601. CrossrefMedlineGoogle Scholar4. LamShubSheps JCS. Reversible dilatation of hypertrophied left ventricle in pheochromocytoma: serial two dimensional echocardiographic observations. Am Heart J. 1985;109:613-5. CrossrefMedlineGoogle Scholar5. Imperato-McGinleyGautierEhlersZulloGoldsteinVaughan JTKMDE. Reversibility of catecholamine-induced dilated cardiomyopathy in a child with a pheochromocytoma. N Engl J Med. 1987;316:793-7. CrossrefMedlineGoogle Scholar6. ScullyMarkMcNeelyMcNeely REWB. Case records of the Massachusetts General Hospital. Case 15-1988. A 26-year-old woman with cardiomyopathy, multiple strokes, and an adrenal mass. N Engl J Med. 1988;318:970-81. CrossrefMedlineGoogle Scholar7. KarchBillingham SM. Myocardial contraction bands revisited. Hum Pathol. 1986;17:9-13. CrossrefMedlineGoogle Scholar8. TazelaarKarchStephensBillingham HSBM. Cocaine and the heart. Hum Pathol. 1987;18:195-9. CrossrefMedlineGoogle Scholar9. HoffmanGoodman CP. Pulmonary edema in cocaine smokers. Radiology. 1989;172:463-5. CrossrefMedlineGoogle Scholar10. MorcosFairhurstHenry NAW. Direct but reversible effects of cocaine on the myocardium [Abstract]. J Am Coll Cardiol. 1988;11:71A. Google Scholar11. HaguePerreaultMorgan NCJ. Effects of cocaine on intracellular Ca++ handling in mammalian myocardium [Abstract]. Circulation. 1988;78:359. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From Tufts University School of Medicine, Boston, Massachusetts. For current author addresses, see end of text. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByStroke and Substance AbuseCharacteristics, trends, outcomes, and costs of stimulant-related acute heart failure hospitalizations in the United StatesDrugs and sudden cardiac deathDrugs of Abuse and CardiotoxicityDrug-Induced Takotsubo CardiomyopathyMiocardiopatía de takotsubo desencadenada por la utilización o exposición a drogas de abuso, sustancias químicas o venenos de origen animalCocaineCocaineStroke and Substance AbuseTreating cocaine cardiotoxicity: Does receptor subtype matter?Long-term outcomes in heart transplantation using donors with a history of past and present cocaine use†Stimulant-related Takotsubo cardiomyopathyPathophysiology of Heart FailureDrug-Related Diseases of the Coronary ArteryCardiovascular Toxicity as a Result of Recreational DrugsForensic Pathology Related to Cardiovascular ToxicityAddiction aux drogues stimulantes (cocaïne, méthamphétamine et nouveaux produits de synthèse)HIV Infection and Stroke: the Changing Face of a Rising ProblemCardiac Fas-Dependent and Mitochondria-Dependent Apoptosis after Chronic Cocaine AbuseCharacteristics, Management, and Outcomes of Cocaine-Positive Patients With Acute Coronary Syndrome (from the National Cardiovascular Data Registry)Drug-Related Diseases of the Coronary Artery2012 ACCF/AHA Focused Update Incorporated Into the ACCF/AHA 2007 Guidelines for the Management of Patients With Unstable Angina/Non–ST-Elevation Myocardial Infarction2012 ACCF/AHA Focused Update Incorporated Into the ACCF/AHA 2007 Guidelines for the Management of Patients With Unstable Angina/Non–ST-Elevation Myocardial InfarctionRole of Imaging in the Detection of Reversible CardiomyopathyCocaineElectrocardiographic findings associated with cocaine use in humans: a systematic reviewHemodynamic and Arrhythmogenic Effects of Cocaine in Hypertensive Individuals2011 ACCF/AHA Focused Update Incorporated Into the ACC/AHA 2007 Guidelines for the Management of Patients With Unstable Angina/Non–ST-Elevation Myocardial Infarction2011 ACCF/AHA Focused Update Incorporated Into the ACC/AHA 2007 Guidelines for the Management of Patients With Unstable Angina/Non–ST-Elevation Myocardial InfarctionStroke and Substance AbuseStimulating Stuff: The Pathological Effects of Cocaine and Amphetamines on the Cardiovascular SystemExcited Delirium, Restraints, and Unexpected DeathCocaine and the HeartDrugs of Abuse and CardiotoxicitySeriously StressedCocaine CardiotoxicityRescue extracorporeal circulation as bridge to recovery in fulminant cocaine-induced heart failureInfluence of Donor Cocaine Use on Outcome After Cardiac Transplantation: Analysis of the United Network for Organ Sharing Thoracic RegistryManagement of Cocaine-Induced Chest PainMyocardial Alterations in Drug AbusersACC/AHA 2007 Guidelines for the Management of Patients With Unstable Angina/Non–ST-Elevation Myocardial InfarctionACC/AHA 2007 Guidelines for the Management of Patients With Unstable Angina/Non–ST-Elevation Myocardial InfarctionRadiology of Recreational Drug AbuseRecovery from cardiomyopathy after abstinence from cocaineCardiac Arrest in Patients Who Smoke Crack CocaineSubstance Abuse and the HeartCardiovascular Involvement in Acquired Immune Deficiency SyndromeCocaïnePathology of Drug AbuseTransient Left Ventricular Apical Ballooning After Cocaine Use: Is Catecholamine Cardiotoxicity the Pathologic Link?Cocaine-Induced Chest PainCauses and Evaluation for Reversible EtiologiesEvaluation and Management of the Patient Who Has Cocaine-associated Chest PainCocaine-Associated Chest PainTOXIC CARDIOPATHIESIntravascular Ultrasound-Guided Percutaneous Coronary Intervention in a Human Immunodeficiency Virus-Positive Patient with Cocaine-Associated Acute Myocardial Infarction: Case Report and ReviewStroke and Substance AbuseCocaineCardiac Manifestations in Human Immunodeficiency Virus InfectionProlonged Cardiac Dysfunction After Withdrawal of Chronic Cocaine Exposure in RatsCocaine Produces Cardiac Hypertrophy by Protein Kinase C Dependent MechanismsCardiovascular disorders associated with cocaine use: myths and truthsDisfunción miocárdica aguda reversible tras anestesia intranasal con cocaínaExaggerated cardiovascular effects of cocaine in conscious dogs with pacing-induced dilated cardiomyopathyCocaine use and cardiovascular complicationsCocaine-Associated Chest PainPathophysiology of cocaine abuseDiastolic filling abnormalities by color kinesis in newborns exposed to intrauterine cocaineDrug-Related Diseases of the Coronary ArteryCardiovascular Complications of Cocaine UseCan cocaine abuse exacerbate the cardiac toxicity of human immunodeficiency virus?Cardiomyopathy in AIDS: A pathophysiological perspectiveACC/AHA guidelines for the management of patients with unstable angina and non–st-segment elevation myocardial infarctionA Hunt for Reversibility: Necessary and Fruitful EndeavorToxische Schäden des Herzens durch Alkohol, Anthrazykline und KokainAnaesthetic implications of drug abuse in trauma patientsEffects of the Intracoronary Infusion of Cocaine on Left Ventricular Systolic and Diastolic Function in HumansControlled Laboratory Studies on the Effects of Cocaine in Combination with Other Commonly Abused Drugs in HumansCocaína y corazónCocaine: Pathophysiology and clinical toxicologyCARDIAC INVOLVEMENT IN HIV INFECTIONMechanism of the Systemic, Left Ventricular, and Coronary Vascular Tolerance to a Binge of Cocaine in Conscious DogsAcute, reversible pumonary hypertension associated with cocaine useHalogenated Mazindol Analogs as Potential Inhibitors of the Cocaine Binding Site at the Dopamine TransporterAIDS and the heart: Clinicopathologic assessmentVasospasm and Thrombus Formation as Possible Mechanisms of Stroke Related to Alkaloidal CocaineCardiovascular Complications of CocaineCardiac complications of cocaine abuseCardiovascular Manifestations of Cocaine AbuseCocaine Chest Pain12-Lead and continuous ECG recordings of subjects during inpatient administration of smoked cocaineIntracoronary versus intravenous effects of cocaine on coronary flow and ventricular function.Human immunodeficiency virus infection and systolic myocardial performanceAcute Reversible Cardiomyopathy Associated With the Systemic Inflammatory Response SyndromeSarcoid Cardiomyopathy Precipitated by Pregnancy With Cocaine ComplicationsPsychostimulantsDisorders of Spinal Cord, Nerve, and MuscleEvidence in support of the spasm of resistance vessel concept of ischemic heart disease: An update in 1993Acute intravenous cocaine causes transient depression followed by enhanced left ventricular function in conscious dogs.Cardiac transplantation for probable cocaine-related cardiomyopathy and retransplantation after biventricular supportManagement of cocaine-induced cardiovascular complicationsFrequency of left ventricular dysfunction and other echocardiographic abnormalities in human immunodeficiency virus seronegative intravenous drug usersCocaine: Medical ToxicityReversibility of cocaine-induced cardiomyopathyAdditive myocardial depressant effects of cocaine and ethanolHemodynamic effects of intranasal cocaine in humansCardiovascular Complications of CocaineRecurrent Coronary Vasoconstriction Caused by Intranasal Cocaine: Possible Role for MetabolitesWalter C. Brogan III, MD, PhD, Richard A. Lange, MD, D. Brent Glamann, MD, L. David Hillis, MDConcurrent myocardial and cerebral infarctions after intranasal cocaine use.The effects of acute and chronic cocaine use on the heart.Cardiovascular Complications of Cocaine AbuseCocaine-induced Myocardial Infarction in Patients with Normal Coronary ArteriesRobert L. Minor Jr., MD, Brook D. Scott, MD, Donald D. Brown, MD, Michael D. Winniford, MDRecurrent embolic stroke and cocaine-related cardiomyopathy.Cardiac manifestations of acquired immune deficiency syndrome: A 1991 updateCardiovascular Effects of Cocaine AbuseCocaine: The Newest Risk Factor for Cardiovascular DiseaseCardiovascular complications of cocaineThe cardiovascular effects of cocaineThis and that: The ethnopharmacology of simple phenethylamines, and the question of cocaine and the human heartDrugs of abuseCocaine-induced heart diseasesEmbolic stroke after smoking "crack" cocaine.Cerebrovascular Complications of the Use of the Crack Form of Alkaloidal Cocaine 15 December 1989Volume 111, Issue 12Page: 1039-1040KeywordsAcute myocardial infarctionBloodCardiomyopathiesCatecholaminesCocaineDilated cardiomyopathyHeartIntoxicationLungsMuscular dystrophies Issue Published: 15 December 1989 PDF DownloadLoading ...