tbuckley/cabot-search huggingface dataset:
Psoriasiform napkin dermatitis—a follow-up study
Authors: E.A. NEVILLE, O.A. FINN
Journal: British Journal of Dermatology (1975)

Journal Article Psoriasiform napkin dermatitis—a follow‐up study Get access E.A. NEVILLE, E.A. NEVILLE Department of Dermatology, Stobhill General Hospital, Glasgow, G21 3UW Search for other works by this author on: Oxford Academic Google Scholar O.A. FINN O.A. FINN Department of Dermatology, Stobhill General Hospital, Glasgow, G21 3UW Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 92, Issue 3, 1 March 1975, Pages 279–286, https://doi.org/10.1111/j.1365-2133.1975.tb03077.x Published: 01 March 1975
Salivary cortisol levels and allergy in children: The ALADDIN birth cohort
Authors: Fredrik Stenius, Magnus Borres, Matteo Bottai, Gunnar Lilja, Frank Lindblad, Göran Pershagen, Annika Scheynius, Jackie Swartz, Töres Theorell, Johan Alm
Journal: Journal of Allergy and Clinical Immunology (2011)
Provider Counseling About Health Behaviors Among Cancer Survivors in the United States
Authors: Susan A. Sabatino, Ralph J. Coates, Robert J. Uhler, Lori A. Pollack, Linda G. Alley, Laura J. Zauderer
Journal: Journal of Clinical Oncology (2007)

To examine provider discussion or counseling of US cancer survivors about diet, exercise, and tobacco use.We used 2000 National Health Interview Survey data to examine whether US cancer survivors reported that, within 1 year, a provider (1) discussed diet, (2) recommended they begin or continue exercise, or (3) asked about smoking. We included survivors more than 1 year beyond diagnosis (n = 1,600) and adults without cancer (AWCs; n = 24,636) who saw/talked to a provider within 1 year. We used generalized linear contrasts in bivariable analyses and logistic regression to calculate predicted marginals adjusted for age, sex, comorbidity, usual source of care, and number of provider visits in the prior year.Few survivors reported discussions or recommendations for all three health behaviors (10% of survivors v 9% of AWCs; P = .57). Although report was more likely than among AWCs, few survivors reported diet discussions (30% of survivors v 23% of AWCs; P < .0001) or exercise recommendations (26% of survivors v 23% of AWCs; P < .005), and a minority were asked about smoking (42% of survivors v 41% of AWCs; P = .41). After adjustment, survivors were less likely to report exercise recommendations than were AWCs (22% v 24%, respectively; P = .02). Colorectal cancer survivors were less likely than were AWCs of similar age range to report exercise recommendations (16% v 27%, respectively; P < .003) or smoking discussions (31% v 41%, respectively; P < .05). Cervical cancer survivors were more likely than AWCs of similar age range to discuss smoking (58% v 43%, respectively; P < .001).Findings from this nationally representative sample suggest that many providers may miss opportunities to counsel survivors about healthy behaviors, perhaps particularly colorectal cancer survivors.
Quantification of macrophage migration inhibitory factor mRNA expression in gastric cancer tissues and its clinical significance
Authors: Y. Mohri, K. Tanaka, M. Ohi, C. Miki, T. Mohri, M. Kusunoki, P. J. Johnson
Journal: Gut (2011)

<h3>Introduction</h3> Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine derived from T cells and the pituitary gland. However, several types of solid cancers also secrete MIF, and this factor has been suggested to play an important role in carcinogenesis and the progression of malignancy. In this study, we quantified MIF mRNA expression of gastric cancer tissues and examined its relationship with clinicopathological factors. <h3>Methods</h3> MIF mRNAs of both tumour and normal tissues were quantified by a real-time monitoring reverse-transcription PCR in 133 patients with gastric cancer. The relationship between the grade of MIF expression and clinicopathological factors such as body weight loss, cell type, stage, and prognosis was examined to investigate the clinical significance of intratumoral expression of MIF. <h3>Results</h3> The mean value of MIF mRNA in tumour tissues was 1.56, whereas that of normal gastric tissue was 0.38 (p=0.0011). The amounts of MIF proteins revealed by ELISA correlated with those of the corresponding mRNAs. Patients with protein malnutrition showed a significantly higher expression of MIF mRNA than other subjects and higher expression of MIF mRNA was significantly associated with unfavourable prognosis (p=0.0197). <h3>Conclusion</h3> The general intratumoral expression and close relation with cancer associated malnutrition suggested that MIF might contribute to tumorigenes.
Association between allergic rhinitis and hospital resource use among asthmatic children in Norway
Authors: V. Sazonov Kocevar, J. Thomas, L. Jonsson, E. Valovirta, F. Kristensen, D. D. Yin, H. Bisgaard
Journal: Allergy (2005)

Background: Preliminary evidence suggests that inadequately controlled allergic rhinitis in asthmatic patients can contribute towards increased asthma exacerbations and poorer symptom control, which may increase medical resource use. The objective of this study was therefore to assess the effect of concomitant allergic rhinitis on asthma‐related hospital resource utilization among children below 15 years of age with asthma in Norway. Methods: A population‐based retrospective cohort study of children (aged 0–14 years) with asthma was conducted using data from a patient‐specific public national database of hospital admissions during a 2‐year period, 1998–1999. Multivariate linear regression, adjusting for risk factors including age, gender, year of admission, urban/rural residence and severity of asthma episode, estimated the association between allergic rhinitis and total hospital days. A multivariate Cox proportional‐hazards model estimated relative hazard of readmission according to concomitant allergic rhinitis status. Results: Among 2961 asthmatic children under 15 years of age with at least one asthma‐related hospital admission over a 2‐year period, 795 (26.8%) had a recorded history of allergic rhinitis. Asthmatic children with allergic rhinitis had a 1.72‐times greater hazard of asthma‐related readmissions than asthmatic children without allergic rhinitis. Multivariate analysis revealed that history of concomitant allergic rhinitis was a significant predictor of increased number of hospital days per year (least‐squares mean difference 0.23 days, P &lt; 0.05). Conclusions: Concomitant allergic rhinitis in asthmatic children was associated with increased likelihood of asthma‐related hospital readmissions and greater total hospital days.
Efficacy of pneumococcal vaccine
Authors: D J Powrie
Journal: Thorax (2003)

▴ Whitney CG, Farley MM, Hadler J, et al . Decline in invasive pneumococcal disease after the introduction of protein-polysaccharide conjugate vaccine. N Engl J Med2003;348:1737–46 [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] ▴ Jackson LA, Neuzil KM, Yu O, et al . Effectiveness of pneumococcal polysaccharide vaccine in older adults. N Engl J Med2003;348:1747–55 [OpenUrl][5][CrossRef][6][PubMed][7][Web of Science][8] S treptococcus pneumoniae is the most common cause of pneumonia in the elderly but it is also responsible for bacteraemia, particularly in the very young. These two studies looked at the impact of two vaccines in preventing pneumonia in the elderly and invasive disease in a younger population. In 2000 a 7-valent polysaccharide vaccine was licensed in the USA for use in young children. The first study assessed the incidence of … [1]: {openurl}?query=rft.jtitle%253DNew%2BEngland%2BJournal%2Bof%2BMedicine%26rft.stitle%253DNEJM%26rft.issn%253D0028-4793%26rft.aulast%253DWhitney%26rft.auinit1%253DC.%2BG.%26rft.volume%253D348%26rft.issue%253D18%26rft.spage%253D1737%26rft.epage%253D1746%26rft.atitle%253DDecline%2Bin%2BInvasive%2BPneumococcal%2BDisease%2Bafter%2Bthe%2BIntroduction%2Bof%2BProtein-Polysaccharide%2BConjugate%2BVaccine%26rft_id%253Dinfo%253Adoi%252F10.1056%252FNEJMoa022823%26rft_id%253Dinfo%253Apmid%252F12724479%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1056/NEJMoa022823&link_type=DOI [3]: /lookup/external-ref?access_num=12724479&link_type=MED&atom=%2Fthoraxjnl%2F58%2F8%2F694.atom [4]: /lookup/external-ref?access_num=000182543500002&link_type=ISI [5]: {openurl}?query=rft.jtitle%253DNew%2BEngland%2BJournal%2Bof%2BMedicine%26rft.stitle%253DNEJM%26rft.issn%253D0028-4793%26rft.aulast%253DJackson%26rft.auinit1%253DL.%2BA.%26rft.volume%253D348%26rft.issue%253D18%26rft.spage%253D1747%26rft.epage%253D1755%26rft.atitle%253DEffectiveness%2Bof%2BPneumococcal%2BPolysaccharide%2BVaccine%2Bin%2BOlder%2BAdults%26rft_id%253Dinfo%253Adoi%252F10.1056%252FNEJMoa022678%26rft_id%253Dinfo%253Apmid%252F12724480%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [6]: /lookup/external-ref?access_num=10.1056/NEJMoa022678&link_type=DOI [7]: /lookup/external-ref?access_num=12724480&link_type=MED&atom=%2Fthoraxjnl%2F58%2F8%2F694.atom [8]: /lookup/external-ref?access_num=000182543500003&link_type=ISI
Breast feeding, parental allergy and asthma in children followed for 8 years. The PIAMA birth cohort study
Authors: S Scholtens, A H Wijga, B Brunekreef, M Kerkhof, M O Hoekstra, J Gerritsen, R Aalberse, J C de Jongste, H A Smit
Journal: Thorax (2009)

It is unclear how the association between breast feeding and asthma develops with age of the child and how this association over time is influenced by maternal or paternal allergy. These factors--the age of the child and maternal or paternal allergy--might partly explain the conflicting results observed in cross-sectional studies.The study population consisted of 3115 Dutch children born in 1996/1997 who participated in the PIAMA (Prevention and Incidence of Asthma and Mite Allergy) birth cohort study. Data on breast feeding and asthma (based on wheeze, dyspnoea and prescription of inhaled steroids) were collected by yearly questionnaires. At 8 years, specific immunoglobulin E (IgE) to airborne allergens and bronchial responsiveness were measured. Data were analysed by logistic regression and generalised estimating equations (GEEs), and stratified by maternal and paternal allergic status.35% (n = 1081) of the children were breast fed for >16 weeks. At 8 years of age, 12.6% (n = 392) had asthma. Breast feeding (>16 weeks vs no breast feeding) was significantly associated with a lower asthma prevalence from 3 to 8 years of age, in children of both non-allergic and allergic mothers. The inverse association between breast feeding and sensitisation to airborne allergens at 8 years was non-significant. Breast feeding was not associated with bronchial hyper-responsiveness. No interaction between breast feeding and gender, maternal allergy or paternal allergy was observed in any of the associations.Breast feeding is associated with a lower asthma risk in children until 8 years of age without evidence of attenuation and regardless of the family history of allergy.
Type 2 angiotensin II receptor is downregulated in cardiomyocytes of patients with heart failure
Authors: Toshiyuki Matsumoto, Ryoji Ozono, Tetsuya Oshima, Hideo Matsuura, Taijiro Sueda, Goro Kajiyama, Masayuki Kambe
Journal: Cardiovascular Research (2000)

The human heart expresses type 2 angiotensin (AT(2)) receptor, but the function is poorly defined.In the present study, we investigated (1) the cellular localization of the AT(2) receptor and (2) the relationship between the AT(2) receptor protein expression and the cardiac function of patients with ischemic heart disease. The receptor localization was assessed by immunohistochemistry and the protein expression was quantified by Western blotting in atrial tissues freshly obtained from 22 patients undergoing coronary artery bypass graft surgery (63.0+/-11.0 years old; male ratio, 85%). Prior to the surgery, blood was drawn for determination of atrial-natriuretic hormone level and the left ventricular function was assessed by ultrasound cardiography.The results of immunohistochemistry showed that the AT(2) receptor was localized to cardiomyocytes and was not present in fibroblasts, vascular smooth muscles, or vascular endothelium. Atrial tissues showed various degrees of structural remodeling, but the localization of the AT(2) receptor was not altered in any tissue sections. The amount of the AT(2) receptor was negatively correlated with end-diastolic left ventricular diastolic dimension (r=-0.56, P<0.01), calculated left ventricular mass index (r=-0.51, P<0.02) and the plasma atrial natriuretic peptide (ANP) concentration (r=-0. 62, P<0.01) and positively correlated with left ventricular ejection fraction (r=0.48, P<0.05).(1) The AT(2) receptor is localized to cardiomyocytes independently of the cardiac function. (2) Left ventricular dysfunction is associated with decreased expression of myocardial AT(2) receptor protein.
Signatures of Ecological Resource Availability in the Animal and Plant Proteomes
Authors: James J. Elser, William F. Fagan, Sankar Subramanian, Sudhir Kumar
Journal: Molecular Biology and Evolution (2006)

Although substantial and ecologically significant differences in elemental composition are well documented for whole organisms, little is known about whether such differences extend to lower levels of biological organization, such as the elemental composition of major molecules. In a proteome-scale investigation of 9 plant genomes and 9 animal genomes, we find that the nitrogen (N) content of plant proteins is lower than that in animal proteins. Furthermore, protein N content declines with the intensity of gene expression for plants, whereas the N content of animal proteins shows no consistent pattern with expression. Additional analyses indicate that the differences in N content between plant and animal proteomes and in plant proteins as a function of gene expression cannot be attributed to protein size, GC content, gene function, or amino acid properties. These patterns suggest that ecophysiological selection has operated to conserve N in plants via decreased reliance on N-rich amino acids. This inference was supported by an analysis of conserved and variable sites indicating that the N content of plant amino acids coded by variable sites is similar to that of the sites conserved between plant and animal genomes and shows no association with expression level. In contrast, in animals, the N content of amino acids coded by variable sites is significantly higher than that for conserved sites, suggesting relaxation of selective constraints for N usage in the animal lineage. This constitutes the first evidence for an influence of environmental resource availability on proteomes of multicellular organisms.
Investigation of promoter variations in dendritic cell-specific ICAM3-grabbing non-integrin (DC-SIGN) (CD209) and their relevance for human cytomegalovirus reactivation and disease after allogeneic stem-cell transplantation
Authors: M. Mezger, M. Steffens, C. Semmler, E.-M. Arlt, M. Zimmer, G.-I. Kristjanson, T.F. Wienker, M.R. Toliat, T. Kessler, H. Einsele, J. Loeffler
Journal: Clinical Microbiology and Infection (2008)
Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses
Authors: Sindy H Wei, Hugh Rosen, Melanie P Matheu, M Germana Sanna, Sheng-Kai Wang, Euijung Jo, Chi-Huey Wong, Ian Parker, Michael D Cahalan
Journal: Nature Immunology (2005)
Respiratory muscles and weaning failure
Authors: T Vassilakopoulos, S Zakynthinos, Ch Roussos
Journal: European Respiratory Journal (1996)

Weaning failure is, unfortunately, a rather common phenomenon for mechanically-ventilated patients (especially those with chronic obstructive pulmonary disease (COPD)), and the respiratory muscles play a pivotal role in its development. Weaning fails whenever an imbalance exists between the ventilatory needs and the neurocardiorespiratory capacity. This can happen if there is an increase in the energy demands of the respiratory muscles, a decrease in the energy available, a decrease in neuromuscular competence, or if the respiratory muscles pose an impediment to the heart and blood flow. The imbalance created will lead to weaning failure through the development of respiratory muscle fatigue, hypercapnia, dyspnoea, anxiety and organ dysfunction.
Prospective use of serial questionnaires to evaluate the therapeutic efficacy of 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) in suspected lung cancer
Authors: G J Herder
Journal: Thorax (2003)

<b>Background:</b> A study was undertaken to study the effect of <sup>18</sup>F-fluorodeoxyglucose (FDG) positron emission tomography (PET) on the diagnosis and management of clinically problematic patients with suspected non-small cell lung cancer (NSCLC). <b>Methods:</b> A prospective before-after study was performed in a cohort of all 164 patients (university/community settings) referred for PET between August 1997 and July 1999. PET was restricted to cases where non-invasive tests had failed to solve clinical problems. The impact on diagnostic understanding and management was assessed using questionnaires (intended treatment without PET, actual treatment choice after PET, post hoc clinical assessment). <b>Results:</b> Diagnostic problems especially pertained to unclear radiological findings (n=112; 63%), mediastinal staging (n=36; 20%), and distant staging issues (n=16; 9%). PET findings were validated by reviewing medical records. PET had a positive influence on diagnostic understanding in 84%. Improved diagnostic understanding solely based on PET was reported in 26%. According to referring physicians, PET resulted in beneficial change of treatment in 50%. Cancelled surgery was the most frequent change in treatment after PET (35%). <b>Conclusion:</b> FDG PET applied as "add on" technology in patients with these clinical problems appears to be a clinically useful tool, directly improving treatment choice in 25% of patients. The value of increased confidence induced by PET scanning requires further evaluation.
Employment perspectives of patients with ankylosing spondylitis
Authors: A M J Chorus
Journal: Annals of the Rheumatic Diseases (2002)

To assess the labour market position of patients with ankylosing spondylitis (AS) in relation to disease duration and to identify potential factors in relation to withdrawal from the labour force.A cross sectional mail survey was conducted among 658 patients with AS. Participation in the labour force was defined as having a paid job. The independent effect of duration of disease was examined by an indirect method of standardisation. A broad variety of risk factors were examined separately and in a combined analysis, including sociodemographic factors, disease related variables, coping styles, and work related factors. Attributable and preventable fractions were calculated from the combined analyses to assess the relative importance of the contributing factors.Probability of participation in the labour force was similarly reduced in patients with AS with different durations of disease. Pacing to cope with limitations was the most relevant factor in increasing the risk of withdrawal from the labour force, accounting for 73% of withdrawals. Coping with limitations by often seeking creative solutions, high disease activity, increased age, and insufficient support from colleagues or management were also positively associated with withdrawal from the labour force. Technical or ergonomic adjustments of the workplace, working in large companies, and coping with dependency style through frequent acceptance were negatively associated. Of these factors, technical or ergonomic adjustment was the most relevant in terms of reducing the risk.Sociodemographic factors, disease related factors, coping styles, and work related factors contribute simultaneously to withdrawal from the labour force.
Reptin is required for the transcription of telomerase reverse transcriptase and over-expressed in gastric cancer
Authors: Wenjuan Li, Jiping Zeng, Qiao Li, Li Zhao, Tiantian Liu, Magnus Björkholm, Jihui Jia, Dawei Xu
Journal: Molecular Cancer (2010)

Abstract Background Telomerase is activated in oncogenesis, which confers an immortal phenotype to cancer cells. The AAA + ATPase Reptin is required for telomerase biogenesis by maintaining telomerase RNA (hTER) stability and is aberrantly expressed in certain cancers. Given its role in chromatin remodeling and transcription regulation, we determined the effect of Reptin on the transcription of the telomerase reverse transcriptase ( hTERT ) gene, a key component of the telomerase complex and its expression in gastric cancer. Results Knocking down Reptin or its partner Pontin using small interfering RNA in gastric and cervical cancer cells led to significant decreases in hTERT mRNA, but hTERT promoter activity was inhibited in only Reptin-depleted cells. Reptin interacted with the c-MYC oncoprotein and its stimulatory effect on the hTERT promoter was significantly dependent on functional E-boxes in the promoter. Moreover, Reptin bound to the hTERT proximal promoter and the loss of the Reptin occupancy led to dissociation of c-MYC from the hTERT promoter in Reptin-depleted cells. Reptin inhibition dramatically impaired clonogenic potential of gastric cancer cells by inducing cell growtharrest and over-expression of Reptin was observed in primary gastric cancer specimens. Conclusions The hTERT gene is a direct target of Reptin, and hTERT transcription requires constitutive expression of Reptin and its cooperation with c-MYC. Thus, Reptin regulates telomerase at two different levels. This finding, together with the requirementof Reptin for the clonogenic potential of cancer cells and its over-expression in gastriccancer and other solid tumors, suggests that Reptin may be a putative therapeutic target.
Supersensitivity and gastric emptying after vagotomy
Authors: J. Tinker, N. Kocak, T. Jones, H. I. Glass, A. G. Cox
Journal: Gut (1970)

Investigations were carried out in man and dog to study the validity of Cannon9s law of denervation supersensitivity in relation to parasympathetic denervation of the stomach. Subthreshold doses of carbachol did not accelerate gastric emptying before vagotomy but caused a significant increase in the rate of gastric emptying after vagotomy. These findings may be relevant to aberrations of gastrointestinal motility after vagotomy and may provide the basis of a test for completeness of gastric vagotomy.