tbuckley/cabot-search huggingface dataset:
Revisited Physicochemical and Transport Properties of Respiratory Mucus in Genotyped Cystic Fibrosis Patients
Authors: ERIC DENEUVILLE, CATHERINE PERROT-MINOT, FRANÇOIS PENNAFORTE, MICHEL ROUSSEY, JEAN-MARIE ZAHM, CHRISTINE CLAVEL, EDITH PUCHELLE, SOPHIE de BENTZMANN
Journal: American Journal of Respiratory and Critical Care Medicine (1997)

We investigated the physicochemical and transport properties of sputum samples collected in physiotherapy from a well-documented group of 27 cystic fibrosis (CF) patients with identified CF genotypes. Sputum samples were characterized ex vivo for their water content, surface properties (surface tension and contact angle), rheologic properties (viscosity and elastic modulus), and transport properties (mucociliary and cough transport). These data were analyzed in relation to the clinical status of the patients (FEV1, FVC, Shwachman score, Brasfield score, nutritional status), their genotype, and the degree of infection of their sputa (leukocyte and Pseudomonas aeruginosa counts). We observed negative and significant correlations between mucociliary transport and elastic modulus of the patients' sputum (r = − 0.63, p < 0.01), and between the cough transport and contact angle of the sputum (r = − 0.81, p < 0.0001), respectively. The P. aeruginosa count was also significantly correlated with the sputum water content (r = − 0.53, p < 0.02) as well as with the cough transport of the sputum (r = − 0.62, p < 0.01). In CF patients with a sputum leukocyte count > 2,000/mm3, the sputum water content (p < 0.02), FEV1 (p < 0.05) and FVC (p < 0.02) were significantly lower than those of CF patients with a leukocyte count ⩽ 2,000/mm3. CF patients with a homozygous Δ F 508 genotype had significantly greater values of sputum water content (p < 0.05), and cough-transport capacity (p < 0.05) than did heterozygous patients. No correlation was observed between the sputum properties and any of the clinical data. These results suggest that the control of infection should be emphasized in CF, since it can directly or indirectly modulate the degree of hydration, and therefore the physicochemical and transport properties, of airway secretions.
Permanent closure of a pancreatic duct leak by endoscopic coiling
Authors: R. Lüthen, P. Jaklin, M. Cohnen
Journal: Endoscopy (2007)

A 45-year-old man with a history of chronic pancreatitis was admitted with symptoms of upper abdominal pain. Six months earlier, he had undergone a pancreatic tail resection to remove a suspected tumor (histologically found to be a chronic inflammatory lesion), and a symptomatic cyst (with a diameter of 5 cm) ensued locally.
768-6 Lipid Rich Plaques with Thrombus are Common in Unstable Rest Angina: Observations from Atherectomy Tissue Analysis
Authors: Samin K. Sharma, Billie Fyfe, Ram Bongu, Jeremy Asnes, Jonathan D. Marmur, Thomas Cocke, Orlandino D. Almeida, John A. Ambrose
Journal: Journal of the American College of Cardiology (1995)
Calcium, Calcium Regulatory Hormones, and Calcimimetics
Authors: Claus Peter Schmitt, Tobias Odenwald, Eberhard Ritz
Journal: Journal of the American Society of Nephrology (2006)

Calcemia is a risk factor for cardiovascular (CV) events in dialyzed patients. The relation between serum calcium and cardiovascular events is continuous and linear. Calcium plays a potent role in the genesis of cardiovascular dysfunction, particularly by promoting vascular calcification. Parathyroid hormone (PTH) also is associated with increased CV risk in both primary and secondary hyperparathyroidism. There is a nonlinear relationship between PTH and CV risk; both high and low PTH concentrations increase CV risk. The CV risk profile (BP, dyslipidemia) is strikingly ameliorated by the administration of calcimimetics. Apart from lowering PTH, whether calcimimetics have intrinsic effects on CV risk profile is unknown.
Cost-effectiveness and Resource Allocation—Reply
Authors: Anthony Harris, Suzanne R. Hill, David A. Henry
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Radiofrequency ablation of hepatocellular carcinoma: Long-term results and prognostic factors in 235 Western patients with cirrhosis
Authors: Gisèle N'Kontchou, Amel Mahamoudi, Mounir Aout, Nathalie Ganne-Carrié, Véronique Grando, Emmanuelle Coderc, Eric Vicaut, Jean Claude Trinchet, Nicolas Sellier, Michel Beaugrand, Olivier Seror
Journal: Hepatology (2009)

For the treatment of small hepatocellular carcinoma (HCC), radiofrequency ablation (RFA) is in some centers considered a first-line therapeutic option. However, such a strategy is still under debate with regard to tumor and patient characteristics. In this single-center study we assessed the 5-year survival and prognosis factors in 235 consecutive patients with cirrhosis (Child-Pugh A/B: 205/30) who received RFA as first-line treatment for up to three HCC <or=5 cm (307 tumors; mean diameter: 29 +/- 10 mm; 53 multinodular forms). Among these patients, 67 satisfied the criteria for resection according to the Barcelona Clinic Liver Cancer. Complete ablation was obtained in 222 patients (94%). Overall, 337 RFA sessions were performed including iterative RFA for recurrence. Major complications occurred in three patients (0.9%), including one treatment-related death. After 27 +/- 20 months of mean follow-up, local or distant, or both, tumor recurrence occurred in 16, 88, and 11 patients, respectively. Twenty-nine patients underwent transplantation and were removed from the study at this point. Overall 5-year, recurrence-free, and tumor-free (including results of iterative RFA) survival rates were, respectively, 40%, 17%, and 32%. The overall 5-year survival rate was 76% for operable patients. Factors associated with overall survival were prothrombin activity (hazard ratio [HR] = 0.97, 0.96-0.98; P < 0.0001) and serum levels of alpha-fetoprotein (AFP) (HR = 1.02, 1.02-1.02; P < 0.0001), and factors associated with tumor recurrence were multinodular forms (HR = 2.34; 1.52-3.6; P = 0.0001) and serum AFP levels (HR = 1.015, 1.014-1.016; P = 0.015). Tumor size was associated with local recurrence but not with overall and tumor-free survival.RFA is a safe and effective first-line treatment of HCC up to 5 cm in diameter, especially for patients with a single tumor, a low serum AFP level, and well-preserved liver function.
Abstract 2166: In silico identification and biological evaluation of potent small molecule inhibitors targeting GAB1 pleckstrin homology domain
Authors: Sabrina Dumas, Lei Du-Cuny, Sylvestor Moses, Zuohe Song, Shuxing Zhang, Emmanuelle J Meuillet
Journal: Cancer Research (2012)

Abstract The Grb2-associated binder-1 (GAB1) over-expressed in many cancers represents a novel therapeutic target that integrates signals from different systems such as MET and PI3K/Akt pathways. It mediates processes involved in tumor progression and metastasis. In this study we have identified novel inhibitors targeting the pleckstrin homology (PH) domain of GAB1 for cancer treatment. To this end, a homology model of GAB1 PH domain was constructed, followed by structural refinement using molecular dynamics. The resulting structure was applied to high-throughput virtual screening of 5 million compounds and 19 hits were selected for experimental evaluation. We found that 6 compounds bound to the PH domain of GAB1 as measured by surface plasmon resonance spectroscopy, with a KD. Out of these 6 hits, all of them inhibited the HGF-I induced phosphorylation of GAB1 Tyr627 in T47D and inhibited T47D and MDA-MB-231 breast cancer cell lines proliferation. Three of them exhibited selective binding to GAB1 PH domain as compared to the PH domain of IRS-1 and AKT. This demonstrates for the first time the identification of novel GAB1 PH domain inhibitors which may be used for targeted breast cancer therapy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2166. doi:1538-7445.AM2012-2166
Sports Medicine for the Athletic Female
Authors: Letha Y. Hunter
Journal: JAMA (1980)

title Sports Medicine for the Athletic Female is deceiving, as the book is more a general sports medicine text with a slight emphasis on the female athlete than a text exclusively for the female athlete.   book is distinctive in that a variety of professionals have contributed—a physician, therapist, trainer, psychologist, dentist, educator, psychiatrist, coach, and podiatrist—giving it a cosmopolitan flair.  Although much of the information is not new (eg, Subotnick's chapter, The Foot in Sports), this text does present a logically organized overview of the field of sports medicine. Included are such general subjects as famous female athletes, the history of women in sports, and general guidelines for performing the preseason physical examination, including helpful charting schemes for organized athletic team members. Helpful, too, is a discussion of conditions that may require disqualification from competition.  Then follows a discussion of the physiology of exercise, nutrition, conditioning, and rehabilitation.
Alternatives to Adolescent Drug Abuse
Authors: Sidney Cohen
Journal: JAMA (1977)

SUBSTANCE abuse can be thought of as a maladaptive response to personal and interpersonal difficulties in which drug overuse becomes a way of life preferable to the actual life situation. The life situation may really be chaotic and hopeless or boring and meaningless, or it may simply be perceived to be so by the young person. At any rate, life goals, rewarding activities, the ability to enjoy and look ahead to a fulfilling future do not exist. To provide alternative options to a life-style of drug dependence, the substitute activities ought to be pleasure-giving or be significant now or in the foreseeable future. The principle of providing alternatives to drug abuse has been summarized as follows: "Major inroads on drug abuse cannot be made by stressing the undesirability of drugs. It can only be done by offering more desirable alternative involvements—activities, life-styles and satisfactions which are more rewarding than drug
Barrett's oesophagus length is established at the time of initial endoscopy and does not change over time: results from a large multicentre cohort
Authors: Fouad J Moawad, Patrick E Young, Srinivas Gaddam, Prashanth Vennalaganti, Prashanthi N Thota, John Vargo, Brooks D Cash, Gary W Falk, Richard E Sampliner, David Lieberman, Prateek Sharma
Journal: Gut (2015)

<h3>Objective</h3> It is unclear whether Barrett9s oesophagus (BO) length changes over time or whether the full length of the segment is established at the onset of disease recognition. The objectives of this study were to evaluate the association of age and BO length and to evaluate the changes in BO length over time. <h3>Design</h3> This is a prospective, multicentre cohort study involving patients with BO from five centres. Patients were divided into groups based on the decade of initial diagnosis of BO. The mean BO length and the mean change in BO length were calculated for each age decade. The mean change in BO length was also calculated between the index endoscopy and the last surveillance endoscopy. <h3>Results</h3> 3635 patients with BO were included in the study: 87.8% men, 92.8% Caucasians, mean age 60.9 years and mean BO length 3.5 cm. The mean change in BO length was 0.9 cm. The mean BO length did not significantly change for each age category: &lt;30 years (4.6 cm), 30–39.9 years (3.2 cm), 40–49.9 years (3.1 cm), 50–59.9 years (3.1 cm), 60–69.9 years (3.6 cm), 70–79.7 (4.0 cm) and &gt;80 years (4.5 cm), p=0.47. On subgroup analysis of patients with non-dysplastic BO who had at least 1 year of endoscopic follow up, there was a significant decrease in mean change in BO length across age categories ranging from +1.7 to −0.8 cm, p=0.03. <h3>Conclusions</h3> There was no significant difference in BO length by age category in decades. In addition, the change in BO length from index to follow-up endoscopy was similar among patients &gt;30 years. These findings suggest that a patient9s BO segment length attains its full extent by the time of the initial endoscopic examination.
High-Tech Medicine and Rising Health Care Costs
Authors: Alan H. Magazine
Journal: JAMA (1990)

To the Editor.—  Ginzberg 1 has effectively refuted some simplistic fallacies about the relationship between hightech medicine and rising health care costs. He has also gone beyond the bounds of the traditional narrow debate and focused attention on the larger question: given that demographic factors and public demand will force increased expenditures on health care, how can a democratic society meet that demand? Medical technology can help provide the answer to that in three ways.  First, the medical products industry is a major contributor to the economic growth that Ginzberg suggests is important to balance the effect of future health care expenditures on the overall economy. According to the Department of Commerce, some segments of this industry are expected to grow by 10% in 1990—compared with overall manufacturing growth of 2%. Moreover, the industry chalked up a trade surplus of $1.8 billion in 1989, and exports of US medical products,
TCT-575 Short- and long-term outcomes after percutaneous coronary intervention in patients with lipid core plaque as detected by intracoronary near-infrared spectroscopy.
Authors: Eric Fuh, Owen Mogabgab, Vishal G. Patel, Subhash Banerjee, Emmanouil Brilakis
Journal: Journal of the American College of Cardiology (2013)
Mortality and Causes of Death in a National Sample of Diabetic Patients in Taiwan
Authors: Chin-Hsiao Tseng
Journal: Diabetes Care (2004)

OBJECTIVE—To determine the mortality rate, causes of death, and standardized mortality ratio (SMR) in Taiwanese diabetic patients. RESEARCH DESIGN AND METHODS—A cohort of 256,036 diabetic patients (118,855 men and 137,181 women, aged 61.2 ± 15.2 years) using the National Health Insurance were assembled during the years 1995–1998 and followed up to the end of 2001. Deaths were verified by indexing to the National Register of Deaths. Underlying causes of death were determined from death certificates coded according to the ninth revision of the International Classification of Diseases. The general population of Taiwan was used as reference for SMR calculation. RESULTS—With a total of 1,124,348.4 person-years of follow-up, 43,888 patients died and the crude mortality rate was 39.0/1,000 person-years. Mortality rates increased with age, and diabetic men had a significantly higher risk of death than women. However, mortality rate ratio for men versus women attenuated with increasing age. The overall SMR was 1.63 (1.62–1.65), and SMRs also attenuated in the elderly. Causes of death ascribed to diabetes; cancer; cardiopulmonary disease; stroke; disease of arteries, arterioles, and capillaries; nephropathy; infection; digestive diseases; accidents; and suicide were 28.8, 18.5, 9.0, 10.5, 0.3, 4.8, 6.4, 7.9, 3.2, and 0.8%, respectively. CONCLUSIONS—Approximately 71.2% of the diabetes-related deaths would not be ascribed to diabetes on death certificates in Taiwan. The diabetic men have higher risk of dying than women, and diabetic patients have excess mortality when compared with the general population. For underlying causes of death not listed as diabetes, total cardiovascular death, including cardiopulmonary disease, stroke, and disease of arteries, arterioles, and capillaries, is the most common cause of death, followed by cancer.
Clinical scale zinc finger nuclease (ZFN)-driven gene-editing of PD-1 in tumor infiltrating lymphocytes (TIL) for the potential treatment of metastatic melanoma
Authors: Joal D Beane, Gary K Lee, Zhili Zheng, Nimisha Gandhi, Daniel Abate-Daga, Mini Bharathan, Mary Black, Matthew Mendel, Zhiya Yu, Sadik H Kassim, Smita Chandran, Martin Giedlin, Dale Ando, Ed Rebar, Andreas Reik, Michael Holmes, Philip D Gregory, Nicholas P Restifo, Steven A Rosenberg, Richard A Morgan, Steven A Feldman
Journal: Journal for ImmunoTherapy of Cancer (2014)

Meeting abstracts Multiple inhibitory pathways exist to block the immune response to cancer potentially limiting the effectiveness of adoptive cell transfer (ACT). Programmed cell death-1 (PD-1) is a member of the CD28 superfamily and is expressed on activated T cells. Its ligands, PDL-1 and PDL-2
Comprehensive evaluation of hepatitis B virus reverse transcriptase substitutions associated with entecavir resistance
Authors: Carl J. Baldick, Daniel J. Tenney, Charles E. Mazzucco, Betsy J. Eggers, Ronald E. Rose, Kevin A. Pokornowski, Cheng F. Yu, Richard J. Colonno
Journal: Hepatology (2008)

Virologic resistance emerging during entecavir (ETV) therapy for hepatitis B virus (HBV) requires three substitutions in the viral reverse transcriptase (RT), signifying a high barrier to resistance. Two of these substitutions are associated with lamivudine resistance (LVDr) in the tyrosine-methionine-aspartate-aspartate (YMDD) motif (rtM204V and rtL180M), whereas the other occurs at one or more positions specifically associated with ETV resistance (ETVr): rtT184, rtS202, or rtM250. Although a variety of substitutions at these primary ETVr positions arise during ETV therapy, only a subset give rise to clinical virologic breakthrough. To determine the phenotypic impact of observed clinical and potential new ETVr substitutions, a comprehensive panel of clones containing every possible amino acid at the three primary ETVr positions in LVDr HBV was constructed and analyzed in vitro. A range of replication capacities was observed for the panel, but none of the mutations rescued replication of the LVDr mutant to the wild-type level. More clones with residue rtS202 substitutions were severely impaired than those at rtT184 or rtM250. A wide variety of ETV susceptibilities was observed, ranging from approximately eight-fold (no increase over the LVDr parent) to greater than 400-fold over the wild-type. A correlation was identified between clinically observed substitutions and those displaying higher in vitro replication and resistance, especially those from virologic breakthrough patients.The high number of tolerated and resistant ETVr substitutions is consistent with models predicting that the mechanism for ETVr is through enhancement of LVDr changes in the RT deoxyribonucleotide triphosphate (dNTP)-binding pocket.
14-3-3 Proteins Regulate a Cell-Intrinsic Switch from Sonic Hedgehog-Mediated Commissural Axon Attraction to Repulsion after Midline Crossing
Authors: Patricia T. Yam, Christopher B. Kent, Steves Morin, W. Todd Farmer, Ricardo Alchini, Léa Lepelletier, David R. Colman, Marc Tessier-Lavigne, Alyson E. Fournier, Frédéric Charron
Journal: Neuron (2012)
Molecular defects in ferrochelatase in patients with protoporphyria requiring liver transplantation.
Authors: J Bloomer, C Bruzzone, L Zhu, Y Scarlett, S Magness, D Brenner
Journal: Journal of Clinical Investigation (1998)

Protoporphyria is a genetic disorder in which a deficiency of mitochondrial ferrochelatase activity causes accumulation of protoporphyrin that produces severe liver damage in some patients. In this study, mutations of the ferrochelatase gene were examined in eight unrelated patients who had liver transplantation. RNA was prepared from liver and/ or lymphoblasts, and specific reverse transcriptase-nested polymerase chain reactions amplified and sequenced ferrochelatase cDNAs. Products shorter than normal resulted from an exon 3 deletion in three patients, exon 10 deletion in two, exon 2 deletion in one, and deletion of five nucleotides in exon 5 in one. Sequence of normal-size products revealed no other mutations. Western blot showed a reduced quantity of normal-size ferrochelatase protein in protoporphyria liver compared with normal liver (19-51%, mean 32% of normal). Levels of the mitochondrial protein F1-ATPase beta-subunit were not decreased to a similar degree. Liver ferrochelatase activity was reduced more than could be explained by the decrease in ferrochelatase protein (4-20%, mean 9% of normal). These results establish genetic heterogeneity in the most severe phenotype of protoporphyria. However, the gene mutations found share the property of causing a major structural alteration in the ferrochelatase protein.
The Agnew Clinic-Reply
Authors: M. Therese Southgate
Journal: JAMA (1986)

In Reply.—  I am grateful to Ms Roberts, as I am sure other readers will also be, for identifying Nurse Clymer. With respect to Ms Roberts' second point, that of reaction to the painting, I quote from Lloyd Goodrich,1author of a catalogue raisonne and Eakins' principal biographer:  public reception of the picture was like that of its predecessor [The Gross Clinic]; in polite society it aroused a scandal, and when the artists' jury of the Pennsylvania Academy invited it for the 1891 annual exhibition, the directors refused to let them hang  But that was not the end of it. The following year, when the painting was submitted to the Society of American Artists, the only art organization to which Eakins belonged, they refused to exhibit it. Eakins resigned in bitterness. It was, as Goodrich notes, the last straw.1Moreover, the talk was that Eakins was
Severing the Link Between Coverage Policy and the US Preventive Services Task Force
Authors: Steven H. Woolf, Doug Campos-Outcalt
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal