tbuckley/cabot-search huggingface dataset:
Congenital Diaphragmatic Hernia in Siblings
Authors: E. E. Philipp, M. O. Skelton
Journal: BMJ (1952)

SUBTERTIAN MALARIA mEDTI 1283 a further two tablets three or four days after the initial dose to prevent a relapse, though this additional dose is not commonly needed.The above doses of chloroquine and camoquin are adult doses.and children and infants are given proportionately less.Some Interesting Cases Most of these have been referred to above, but two cases of malarial pneumonia are here included.Case 1.-An elderly man who had been ill for one week complained of slight headache, had pains all over his body, and felt tired.There was no shivering, no vomiting, and no feverishness.Physical examination, apart from reveal- in8Nsevere anaemia, was entirely negative: He was afebrile, and the spleen was not palpable.He was admitted for investigation, and to my surprise malaria parasites were found in his blood.He was given antimalarial therapy, and remained in hospital ten days.During this time his temperature remained subnormal, and the spleen did not become palpable; also there were no rigors.Quinine followed by pamaquin, and iron preparations for the anaemia, brought about a cure within three months.Case 2.-A young woman complained on admission of headache, generalized body pains, and feverishness.There were no rigors and no other symptoms.Physical examina-
OSTEOMYELITIS WITH BONE TRANSPLANTATION
Authors: FRANK A. HAMILTON
Journal: JAMA (1913)

of the voice sounds by which their quality becomes more amphoric and their duration prolonged into an echo arc the Striking characters which when accentuated hv stelh- oscopic pressure indicate pathologic changes in the vis- cera; (5) that the character and distribution of vocal signs over the normal chest are sufficiently constant, so that a topographic study of the chest by auscultation may definitely suggest, through recognition of departures from the normal, the intensity and distribution of mor- bid changes within the lungs, even when these changes are too slight to appeal to the senses through any other method.
In Praise of Imperfection: My Life and Work
Authors: Carol D. Weiss
Journal: JAMA (1988)

<i>In Praise of Imperfection</i>seems like a disingenuous title for an autobiography of the fourth woman to receive the Nobel Prize in medicine. Yet the title also reveals an outlook that is philosophic and detached, but compassionate and modest. Dr Levi-Montalcini brings this dual perspective to the telling of an extraordinary life story. She was born in 1909 in Turin, Italy. Daughter of successful and highly assimilated "Israelites," she grew up in a comfortable social milieu, isolated from the traumas of World War I and the rise of fascism in the early 1920s. Although she describes her family members and friends with affection, Dr Levi-Montalcini also experienced "a profound sense of isolation." As a child she avoided physical contact with her father and governess, and as an adolescent she felt she had "deficiencies in matters of sociability and sports." Believing that she lacked the natural talents of her siblings—her twin
IDH1 mutations are detected in 6.6% of 1414 AML patients and are associated with intermediate risk karyotype and unfavorable prognosis in adults younger than 60 years and unmutated NPM1 status
Authors: Susanne Schnittger, Claudia Haferlach, Madlen Ulke, Tamara Alpermann, Wolfgang Kern, Torsten Haferlach
Journal: Blood (2010)
The lung in closeview: a corrosion casting study on the vascular system of human foetal trachea
Authors: P Strek, M Nowogrodzka-Zagorska, JA Litwin, AJ Miodonski
Journal: European Respiratory Journal (1994)

The aim of this study was to examine the tracheal vasculature in 5 month human foetuses, and to determine whether it differs from that previously described by other authors for adult human trachea. The vascular bed was visualized using the technique of corrosion casting and examined by scanning electron microscopy. The arrangement of larger vessels: longitudinal tracheo-oesophageal arteries and veins, as well as their segmental branches running circumferentially in the intercartilaginous spaces, was similar to that observed in the trachea of adults. However, no blood sinuses reported to occur in the submucous venular plexus of the human trachea could be found in the foetuses. It is postulated that the possible functions of such sinuses acting as the capacitance system are related to the functional respiratory tract; hence, this vascular specialization is not yet developed in the foetus.
Cancer and Herbs
Authors: David A. Kessler
Journal: New England Journal of Medicine (2000)

Bestselling books perpetuate the myth that natural products such as herbs and other “dietary supplements” tend to be safer than conventional medicines.1 Once relegated to health food stores, these products now fill pharmacy and supermarket shelves. So-called natural substances are more popular than ever. Fueled by congressional passage of the Dietary Supplement Health and Education Act of 1994,2 which deregulated the industry by limiting the role of the Food and Drug Administration (FDA), the popularity of dietary supplements has created a $15-billion-a-year industry.In this issue of the Journal, Nortier et al. present evidence of an association between the use . . .
Effects of corticosteroids on bilirubin metabolism in patients with Gilbert's syndrome
Authors: Hideki Ohkubo, Kunio Okuda, Shinji Iida
Journal: Hepatology (1981)

To elucidate the mechanism whereby corticosteroids decrease the serum bilirubin concentration, changes in bilirubin metabolism were studied in patients with Gilbert's syndrome using a bilirubin load test and/or nicotinic acid test before and after corticosteroid treatment. Steroid administration increased hepatic clearance and uptake of bilirubin; the transfer rate for biliary excretion was unaffected. These results suggest that the main effect was enhancement of hepatic uptake or storage of bilirubin, which may be an important mechanism whereby corticosteroids reduce serum bilirubin concentrations in various liver disorders.
Points from Letters: Abortion and Illegitimacy
Authors: R. T. Booth
Journal: BMJ (1970)

a very obvious reference number so that further information could be obtained from the records library, if required.This would save a great deal, not only of time, but of tattered and bulging records envelopes, which become like a maze when some ear- lier information is required.I make these suggestions having seen this problem from two points of view, and because, from my experience,
Neonatal Barbiturate Withdrawal
Authors: Byron F. Schweigert
Journal: JAMA (1972)

<h3>To the Editor.—</h3> In the report by Bleyer and Marshall of neonatal barbiturate withdrawal in a child whose mother was a barbiturate addict (221:185, 1972), the authors believed this to be the first recorded case of neonatal barbiturate withdrawal syndrome. However, Desmond et al in February 1972 reported neonatal withdrawal in 15 infants born to mothers receiving barbiturates.<sup>1</sup>Of these 15 infants, four were born to mothers receiving physician-prescribed therapy with phenobarbital for anxiety or sedation, and seven infants were born to epileptic mothers who were treated with phenobarbital in combination with other anticonvulsants. The maternal dosage in the first group varied from only 90 to 120 mg of phenobarbital daily. Thus, much smaller doses than those reported by Bleyer and Marshall appear to be capable of causing a barbiturate withdrawal syndrome.
Oral Liquid Furosemide in Congestive Heart Failure
Authors: ROSA NIAZOV
Journal: Annals of Internal Medicine (1985)

Letters and Corrections1 September 1985Oral Liquid Furosemide in Congestive Heart FailureROSA NIAZOV, M.D., JUDITH BAR-YOCHAI, M.D., JOSEPH ALCALAY, M.D., LEON ALKALAY, M.D., D.G.M.ROSA NIAZOV, M.D.Search for more papers by this author, JUDITH BAR-YOCHAI, M.D.Search for more papers by this author, JOSEPH ALCALAY, M.D.Search for more papers by this author, LEON ALKALAY, M.D., D.G.M.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-103-3-477_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Vasko and associates (1) have recently reported the alteration in furosemide absorption in patients with decompensated congestive heart failure. We have recently completed a clinical trial involving 20 bedridden patients with severe decompensated congestive heart failure. The patients were treated at home with the sodium salt of furosemide given orally in liquid form from the content of vials for injections, instead of with tablets. Before the trial all the patients had frequently been hospitalized because of severe congestion or pulmonary edema. During our study, over 36 months, 10 patients did not require hospitalization at all, 9 were...Reference1. VASKOCARTWRIGHTKNOCHELNIXONBRATER MDJJD. Furosemide absorption altered in decompensated congestive heart failure. Ann Intern Med. 1985;102:314-8. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Home Care Unit Kupat-Holim, Rishon-Lezion District Sackler School of Medicine Tel-Aviv Israel PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDrug Absorption in the Management of Congestive Heart Failure: Loop DiureticsEffects of Various Modalities of Oral Furosemide Administration in Mild or Severe Congestive Heart Failure 1 September 1985Volume 103, Issue 3Page: 477-477KeywordsClinical trialsEdemaHeart failureHospitalizationsSaltsSodium Issue Published: 1 September 1985 PDF downloadLoading ...
Inflammation and Coronary Artery Disease
Authors: R. Wayne Alexander
Journal: New England Journal of Medicine (1994)

Recent research suggests that focal inflammation in the coronary arteries may be involved in the genesis of unstable coronary syndromes. In this issue of the Journal, Liuzzo et al.1 report that the acute-phase reactants, C-reactive protein and serum amyloid A protein, were elevated in most of their patients with a diagnosis of unstable angina (based on the initial absence of elevated cardiac-enzyme levels), including those who subsequently proved to have had a myocardial infarction. The patients with elevated levels of acute-phase reactants, which reflect the stimulation of hepatic production by circulating inflammatory mediators such as cytokines, had a less favorable . . .
Arterial oxygenation. Mechanisms for improvement during partial cardiopulmonary support
Authors: H. Don
Journal: JAMA (1974)

THIS case is presented to illustrate the possible roles of factors that relieve arterial hypoxemia during partial venous-arterial extracorporeal oxygenator support (ECOS).<sup>1</sup> <h3>Report of a Case</h3> The patient was a 50-year-old man with a one-year history of rheumatic heart disease. Medical management had been virtually absent because of his refusal to consult a physician regularly. He was admitted to the emergency ward with refractory pulmonary edema and immediately suffered a cardiac arrest. Resuscitation was difficult, requiring nearly three hours, with repeated episodes of cardiac arrest. Cardiac catheterization was not thought advisable because of his critical condition. Six hours after admission, while he was still hypotensive and in coma, replacement of the aortic and mitral valves was performed. After surgery, reexploration was required twice because of bleeding. He was treated with increasing amounts of isoproterenol and dopamine hydrochloride, but remained anuric and hypotensive. Because of rapid atrial fibrillation, counterpulsation by
Controversy over generic substitution
Authors: J. Emery, A. McKenzie, C. Bulsara, D. Holman
Journal: BMJ (2010)

Generic substitution1 has been permitted for several years in Australia but still causes problems for patients. We conducted a qualitative study of 104 Western Australian senior citizens with at least one chronic disease exploring their views and experiences of taking drugs safely. The most important and consistent theme related to generic substitution and …
Abstract 2314: The chromatin structure regulates selective glucocorticoid receptor recruitment to the genome in intact tissue.
Authors: Lars Grontved, Sam John, Songjoon Baek, Ying Liu, John Buckley, Charles Vinson, Greti Aguilera, Gordon L. Hager
Journal: Cancer Research (2013)

Abstract The dissection of regulatory pathways in physiological and pathophysiological states and during pharmacological intervention necessitates the application of biochemical and genomic approaches in intact target tissues. The hypothalamus-pituitary-adrenal axis is a highly conserved neuroendocrine pathway that results in the synthesis of glucocorticoid hormones from the adrenal gland to control reactions to stress and inflammatory processes. Exploiting a mouse model in which animals have been adrenalectomized to remove endogenous glucocorticoids, we monitor changes of the chromatin landscape in liver, following a single glucocorticoid injection, using ChIP-seq and DNase-seq methodologies. We observe that GR exclusively occupies accessible chromatin, demonstrating that accessible chromatin can be highly predictive of transcription factor occupancy in tissue. Importantly, changes in RNA polymerase II recruitment to GR regulated genes are associated with proximal regions of induced and repressed chromatin accessibility. Underscoring the highly tissue-specific GR-dependent transcriptional response, GR binding sites in other cell types are occluded in liver through highly positioned nucleosomes and inaccessible chromatin. Remarkably, we demonstrate that sixty two percent of GR binding sites in liver are associated with C/EBPbeta occupancy. At the majority of these sites chromatin is pre-programmed, suggesting a priming function of C/EBPbeta in GR recruitment. However, at a subset of GR binding sites C/EBPbeta loading is assisted by GR recruitment in conjunction with de novo chromatin remodeling. Disruption of C/EBPbeta binding to chromatin using a dominant negative C/EBP targeted to the liver results in an attenuation of pre-programmed chromatin accessibility, GR recruitment and GR induced chromatin remodeling only at sites occupied by GR and C/EBP. Our results demonstrate a highly cooperative mechanism by which C/EBP regulates selective GR binding to the genome in liver tissue and provides a mechanism for phenotypic similarities described for GR and C/EBP mouse models. We suggest that the selective targeting of GR in other tissues is likely mediated by the combined action of cell-specific priming proteins and chromatin remodelers. Citation Format: Lars Grontved, Sam John, Songjoon Baek, Ying Liu, John Buckley, Charles Vinson, Greti Aguilera, Gordon L. Hager. The chromatin structure regulates selective glucocorticoid receptor recruitment to the genome in intact tissue. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2314. doi:10.1158/1538-7445.AM2013-2314
Pointing with focussing devices
Authors: Wolfram Schultz
Journal: Behavioral and Brain Sciences (1997)

Evolutionary pressure selects for the most efficient way of information processing by the brain. This is achieved by focussing neuronal processing onto essential environmental objects, by using focussing devices as pointers to different objects rather than reestablishing new representations, and by using external storage bound to internal representations by pointers. Would external storage increase the capacity of cognitive processing?
A piece of my mind. Respect for the dead
Authors: D. G. Smith
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Transient analysis of the canine cerebrovascular response to carbon dioxide.
Authors: D A Wilson, R J Traystman, C E Rapela
Journal: Circulation Research (1985)

Cerebral venous outflow and carbon dioxide transients were studied during five different transitional states: (1) on and off 10% carbon dioxide breathing, (2) on and off hyperventilation, (3) on 7% carbon dioxide breathing, (4) on 10% carbon dioxide breathing initiated from 7% carbon dioxide breathing, and (5) on 10% carbon dioxide breathing initiated during intracarotid papaverine infusion, in pentobarbital anesthetized, paralyzed, mechanically ventilated dogs. Plots of the temporal relationships between these variables indicated that cerebral blood flow is closely related with cerebral venous carbon dioxide tension but not arterial carbon dioxide tension. The rate at which flow changed upon transition from one steady state to another was phase dependent, in that longer times were required to establish stable conditions in the on phase than in the off phase. The magnitude of the maximum rates of change in cerebral blood flow achieved during transition was influenced both by the size of the forcing function and the level of flow present at the time the response was initiated. Directional changes had no effect upon the maximum rate of the flow change as long as equivalent-sized forcing functions were employed and the initial blood flow levels were similar between responses. However, faster flow transients could be produced by increasing either of the latter two factors. These findings are consistent with the hypothesis that it is either tissue carbon dioxide tension or cerebral venous carbon dioxide tension that is the important variable regulated by cerebral blood flow. The rate-limiting factor in the response appears to be carbon dioxide delivery rate and not the rate of carbon dioxide diffusion.
862 DECREASED EXPRESSION OF MIR-199A-5P CONTRIBUTES TO INCREASED CELL INVASION BY FUNCTIONAL DEREGULATION OF DDR1 ACTIVITY IN HEPATOCELLULAR CARCINOMA
Authors: Q. Shen, S. Beckebaum, S. Iacob, F. Weber, C.G. Klein, A. Paul, G. Gerken, V.R. Cicinnati
Journal: Journal of Hepatology (2010)
Respiratory Failure from Procainamide-induced Myopathy
Authors: Rajeev V. Venkayya
Journal: Annals of Internal Medicine (1993)

Letters15 August 1993Respiratory Failure from Procainamide-induced MyopathyRajeev V. Venkayya, R. Michael Poole, and William H. PentzRajeev V. VenkayyaSearch for more papers by this author, R. Michael PooleSearch for more papers by this author, and William H. PentzSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-4-199308150-00026 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Procainamide can cause respiratory failure [1-3] that has been attributed to diaphragmatic weakness from impaired neuromuscular junction transmission; in previously reported cases, all but one patient had preexisting myasthenia gravis [3]. We report a patient who, while taking procainamide, developed respiratory failure caused by necrotizing myopathy with diaphragm involvement. Electrodiagnostic evaluation showed no neuromuscular junction abnormality.A 74-year-old man developed supraventricular arrhythmias after coronary artery bypass grafting and was treated with procainamide. Two weeks later arm weakness and back and shoulder pain developed. Physical examination showed muscle tenderness and symmetric proximal weakness. Reflexes and sensation were normal. ...References1. Drachman DA, Skom JH. Procainamidea hazard in myasthenia gravis. Arch Neurol. 1965; 13:316-20. Google Scholar2. Godley PJ, Morton TA, Karboski JA, Tami JA. Procainamide-induced myasthenic crisis. Ther Drug Monit. 1990; 12:411-4. Google Scholar3. Javaheri S, Logemann TN, Corser BC, Guerra LF, Means E. Diaphragmatic paralysis. Am J Med. 1989; 86:623-4. Google Scholar4. Fontiveros ES, Cumming WJ, Hudgson P. Procainamide-induced myositis. J Neurol Sci. 1980; 45:143-7. Google Scholar5. Lewis CA, Boheimer N, Rose P, Jackson G. Myopathy after short term administration of procainamide. Br Med J (Clin Res Ed). 1986; 292:593-4. Google Scholar Author, Article, and Disclosure InformationAuthors: Rajeev V. Venkayya; R. Michael Poole; William H. Pentz PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byToxic MyopathiesNeurological complications of cardiovascular drugsProcainamideNeurologic complications of arrhythmia treatmentANTIDYSRHYTHMIC DRUGSProcainamideElectromyography of the diaphragm in neuromuscular diseasePositive inotropic drugs and drugs used in dysrhythmiasProcainamide 15 August 1993Volume 119, Issue 4Page: 345-346KeywordsAntinuclear antibodiesBiopsyCreatine kinaseElectromyographyMuscle biopsiesMusclesNervesReflexesRespiratory failureUrine ePublished: 15 August 2000 Issue Published: 15 August 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Target Levels for Low-Density Lipoprotein in Patients With Coronary Heart Disease
Authors: Hanna Bloomfield Rubins
Journal: JAMA (1994)

<h3>To the Editor.</h3> —I am writing in reference to the recently published Summary of the Second Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II).<sup>1</sup>The initial guidelines issued by this panel 5 years ago were enormously influential in shaping practice and focusing the debate in this area. Undoubtedly, this update will be widely read and extensively discussed as well. It is therefore unfortunate that the article presents the panel's conclusions without providing its rationale. The article is unreferenced and there is no mention of the methods used to gather and analyze the relevant supporting evidence. The decision to lower the low-density lipoprotein (LDL) cholesterol goal for coronary heart disease (CHD) patients to 100 mg/dL (2.6 mmol/L) is one example of a controversial recommendation<sup>2</sup>for which a discussion of the supporting data