tbuckley/cabot-search huggingface dataset:
Correction: Dose of Amphotericin B
Authors: BURT ADELMAN
Journal: Annals of Internal Medicine (1979)

Letters and Corrections1 November 1979Correction: Dose of Amphotericin BBURT ADELMAN, M.D.BURT ADELMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-91-5-798_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In our letter on the treatment and diagnosis of aspergillosis in a leukemic patient in the August issue (1), an unfortunate error was made in transcribing the letter from our manuscript. We indicated that amphotericin B was given in a dose of 40 mg q.o.d.; this appeared in print as 40 mg four times a day....Reference1. ADELMANBENTMANROSENTHALSMITHBRIDGESHOLMES BAPBKW. Treatment of aspergillosis in leukemia. Ann Intern Med. 1979;91:323-4. Letter. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: BURT ADELMAN, M.D.Affiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTime to Junk Junk Latin?JAMES O. MORSE, M.D. 1 November 1979Volume 91, Issue 5Page: 798-798KeywordsAmphotericinAspergillosis ePublished: 1 December 2008 Issue Published: 1 November 1979 PDF downloadLoading ...
The Use of Mammography for Screening
Authors: Daniel B. Kopans
Journal: JAMA (1994)

<h3>To the Editor.</h3> —There is a trend on the part of the epidemiologic community to try to find reasons to withdraw support for screening women aged 40 to 49 years for breast cancer and a disturbing lack of balanced scientific analysis. This trend is reflected in the paper by Dr Kerlikowske and colleagues.<sup>1</sup>Their conclusions are biased and certainly more sweeping than the data justify, and the quoted historical data concerning screening are factually incorrect. The meta-analysis cited by the authors used out-of-date numbers. Fletcher et al<sup>2</sup>reported that the mortality benefit in five of the eight randomized, controlled trials for women aged 40 to 49 years ranges from 22% in the Edinburgh study<sup>3</sup>to 49% in the Malmo trial,<sup>4</sup>not the 13% to 23% cited by Kerlikowske et al. It is specious to suggest that these results are "nonsignificant" since the trials were not designed
District Branches of the American Medical Association.
Authors: G. C. Savage
Journal: JAMA (1906)

Nashville, Tenn., Aug. 14, 1906. <h3>To the Editor:</h3> —Since I learned of the intention on the part of the profession of Kansas, Missouri, Oklahoma, Arkansas and Texas to organize the Southwestern District Branch of the American Medical Association, I have been waiting to see if some one else would not give expression to the opinion that such organizations should be effected immediately all over the United States. Two weeks ago I introduced the discussion of this matter at the meeting of the Nashville Academy of Medicine, and found that every member present viewed the matter as I do. They emphasized their desire for such an organization in our territory by the creation of a committee, consisting of Dr. A. B. Cooke of this city and the undersigned, to undertake the work at once. We have called a meeting for this purpose to be held in Chattanooga October 2, at 9
Selective Biliary Cannulation Using Pancreatic Guide-Wire Placement: Further Evidence Needed to Support the Use of an Already Known Technique
Authors: Y. González Lama, L. Abreu, J. Calleja, M. Vera, A. Garrido, P. Escartín
Journal: Endoscopy (2004)

We read with interest the recent article by Maeda et al. [1] about the placement of a guide wire in the pancreatic duct to facilitate selective deep biliary cannulation in difficult cases. We have been using this technique for almost 4 years at our center, since it was previously described by Dumonceau et al. in 1998 [2]. Our experience with the use of this technique has been satisfactory (it increases the rate of bile duct cannulation, with no apparent increase in the rate of adverse events), but it will only be possible to recommend the wider use of this procedure for bile cannulation after the conclusions of an ongoing multicenter trial have been published.
Estradiol coated stents for the prevention of restenosis in native coronary arteries: Results from the randomized multicentric study EASTER
Authors: Flavio Airoldi, Carlo Di Mario, Goran Stankovic, Carlo Briguori, Patrizia Presbitero, Flavio Ribichini, Vassilis Spanos, Matteo Montorfano, Angela Ferrari, Antonio Colombo
Journal: Journal of the American College of Cardiology (2003)
Scientists Probe Role of Genes, Environment in Parkinson Disease
Authors: Bridget M. Kuehn
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Transfusions at Night
Authors: Paul T. Wertlake
Journal: JAMA (1975)

<h3>To the Editor.—</h3> Concern for effective and safe use of blood products in this country has led to the present activities in formation of an American Blood Commission. In the interim period, until the American Blood Commission becomes fully operational and resultant benefits become realized by the American public, the medical profession can take a simple action to increase safety substantially in transfusion of blood products. That is strictly to limit transfusion of blood products to daytime periods, except for the relatively small number of transfusions that are critically needed to sustain life. This is a small detail in scheduling of orders for patients that probably escapes attention of most physicians. Evening and night staffing of most hospital nursing units is substantially lower than day shifts. This means that patients receiving blood products during evening or night hours are often poorly observed and somtimes not observed at all. Thus, detection
Caloric restriction delays cardiac ageing in rats: role of mitochondria
Authors: Bernd Niemann, Ying Chen, Hassan Issa, Rolf-Edgar Silber, Susanne Rohrbach
Journal: Cardiovascular Research (2010)

We tested whether long-term caloric restriction (CR) corrects pre-existing manifestations of cardiac ageing in rats.The age-specific effects of CR (-40%, 6 months) on mortality, left ventricular (LV) function, mitochondrial function, oxidative damage, and apoptosis were analysed in young (6 + 6 months) and senescent rats (24 + 6 months). CR in senescent rats significantly reduced mortality. LV and cardiomyocyte hypertrophy were reduced together with the mRNA expression and plasma concentrations of overload indicators BNP/ANP. Mitochondrial function was improved, resulting in lower oxidative damage and apoptotic activation. In particular, the pro-apoptotic Bcl-xS/Bcl-xL isoform pattern, mitochondrial translocation of Bax, release of cytochrome C into cytosol, and caspase-9 activation were reduced in comparison to age-matched rats on the control diet. However, CR resulted only in minor changes in young rats. Serum obtained from old control or CR rats was used for in vitro experiments. H9C2 cardiomyoblasts and adult rat ventricular cardiomyocytes preconditioned with CR serum demonstrated a low Bcl-xS/Bcl-xL ratio. H9C2 cells were resistant against H(2)O(2)-mediated loss of mitochondrial membrane potential, apoptosis activation, and reduced cell viability. Thus, beneficial effects of CR are mediated through circulating factors and can be mimicked with CR serum. However, this protection critically depended on a high Bcl-xL protein expression as seen after siRNA-mediated Bcl-xL knockdown.CR is cardioprotective in senescent myocardium by correcting pre-existing mitochondrial dysfunction and apoptotic activation and by preventing deterioration in LV function. Therefore, interventions that mimic these effects of CR may represent an additional therapeutic option for the aged or failing heart.
Technology transfer—from agnogenic portal vein thrombosis to agnogenic myeloid metaplasia
Authors: Charles L. Witte, Marlys H. Witte
Journal: Hepatology (1988)

In a prospective study of 33 adults with portal vein thrombosis unrelated to a liver tumor, we have assessed the prevalence of primary myeloproliferative disorders using conventional criteria and cultures of bone marrow progenitor cells. A primary myeloproliferative disorder was documented in 14 patients investigated at the time of recognition of portal vein thrombosis. Among these 14 patients, the main clue to the presence of the myeloproliferative disorder was (a) the observation of suggestive abnormalities of peripheral blood cell counts in 4 patients; (b) characteristic findings at bone marrow biopsy or determination of total red cell volume in 3 patients; and (c) formation of “spontaneous” erythroid colonies in cultures of bone marrow progenitor cells in erythropoietin-poor medium in 7 patients. In 2 other patients, agnogenic myeloid metaplasia with myelosclerosis of apparently recent onset developed 5 yr after recognition of portal vein thrombosis. In conclusion, primary myeloproliferative disorders—in a full-blown or latent form, or at an early stage—are a major cause of portal vein thrombosis.
ACUTE SUPPURATIVE PEEITONITIS (LOCAL, SPREADING, DIFFUSE AND GENERAL)ORATION ON SURGERY AT THE FIFTY-EIGHTH ANNUAL SESSION OF THE AMERICAN MEDICAL ASSOCIATION, ATLANTIC CITY, JUNE 4-7, 1907.
Authors: WILLIAM H. WATHEN
Journal: JAMA (1907)

In thanking you for my election at the last annual meeting of the American Medical Association to deliver the Oration on Surgery on this occasion, I beg to express my high appreciation of the great honor conferred; for it is truly an honor to represent, in this capacity, the largest and most representative national medical association of any age or of any country. I feel the honor more keenly because I am but the humble follower of many of America's most distinguished surgeons. In selecting the subject of my address I am mindful of the fact that the essential questions involved in the study of the etiology, pathology, diagnosis and treatment of acute suppurative peritonitis are of equal interest to the internist and the surgeon. The greatest success of surgery in saving life in these cases depends on early surgical diagnosis and timely operation, before pathologic conditions develop that may
Amiodarone: Reevaluation of an Old Drug
Authors: Philip J. Podrid
Journal: Annals of Internal Medicine (1995)

Purpose: To review the pharmacology, electrophysiology, and toxicity of amiodarone and to discuss the clinical results produced when amiodarone is used as therapy for patients with atrial fibrillation, patients with nonsustained ventricular tachycardia and cardiomyopathy, patients who have recently had myocardial infarctions, and patients who have survived out-of-hospital cardiac arrest caused by ventricular tachycardia or ventricular fibrillation. Data Sources: Animal and clinical studies involving the pharmacology and electrophysiology of amiodarone and clinical trials in which amiodarone was used as therapy for the arrhythmias noted above were reviewed. Study Selection: Relevant studies that reported on the efficacy and toxicity of amiodarone and on long-term therapy using amiodarone were reviewed, and their data were summarized. Reports of ongoing trials using amiodarone were also reviewed and summarized. Results: Amiodarone is useful for the treatment of many rhythm disturbances. Although side effects from this agent are common, serious toxicity necessitating discontinuation of therapy is infrequent. Unlike other antiarrhythmic agents, amiodarone has not been shown to increase mortality in any population studied. Conclusion: Amiodarone, a unique antiarrhythmic agent with many pharmacologic actions, is effective in the treatment of a wide range of rhythm abnormalities. Several large, randomized trials will provide further information about the clinical usefulness of this agent.
Recent Diversification Rates in North American Tiger Beetles Estimated from a Dated mtDNA Phylogenetic Tree
Authors: Timothy G. Barraclough, Alfried P. Vogler
Journal: Molecular Biology and Evolution (2002)

Species-level phylogenies derived from DNA sequence data provide a tool for estimating diversification rates and how these rates change over time, but to date there have been few empirical studies, particularly on insect groups. We use a densely sampled phylogenetic tree based on mitochondrial DNA to investigate diversification rates in the North American tiger beetles (genus Cicindela). Using node ages estimated from sequence data and calibrated by biogeographical evidence, we estimate an average per-lineage diversification rate of at least 0.22 ± 0.08 species/Myr over the time interval since the most recent colonization that led to a radiation within the continent. In addition, we find evidence for a weak, recent increase in the net diversification rate. This is more consistent with a late Pleistocene increase in the speciation rate than with a constant rate of background extinction, but the results are sensitive to the dating method and taxon sampling. We discuss practical limitations to phylogenetic studies of diversification rates.
Supracondylar Fractures of the Humerus in Children
Authors: William J. Mitchell
Journal: JAMA (1961)

A 10-year follow-up study was made of 83 children with supracondylar fractures of the humerus. In one group the initial treatment was closed reduction. The end result in most of these patients included some loss of carrying angle and some limitation of motion at the elbow. In 3 patients the closed reduction was followed promptly by signs of ischemia that had to be relieved by applying Dunlop's traction. In the other group the initial treatment was by Dunlop's method with skin traction; it was followed by minimal loss of elbow motion, less deformity, and no vascular complications. The superior results in the second group were attributed to the effect of continuous traction in preventing medial and lateral tilting of the distal fragment of the humerus.
THE EUSCOPE AS AN AID TO MICROSCOPY
Authors: WILLIAM G. EXTON
Journal: JAMA (1924)

Recent years have witnessed a great expansion in the use of the microscope in industry as well as in science with the result that routine microscopy, which was formerly done by self-selected specialists, must now be entrusted to technicians. The visual acuity of technicians, especially in such routine work as counting objects or searching for casts, tubercle bacilli and other microscopic objects, thus becomes a matter of prime importance, not only because of its effects on reliability and accuracy, but particularly because the maintenance of visual acuity in persons with good vision is wholly dependent on freedom from eyestrain, fatigue and toxins. The physiologic optics of microscopy are rendered exceedingly complex by the multiplicity of fine muscular adjustments, intricate nerve mechanisms and selective action of diverse stimuli on the delicate nerve end structure of the retina. All these are involved in the impairment of visual acuity and the production of
Clinical Trials in Assessing the Effects of Nutrition on Blood Pressure
Authors: Friedrich C. Luft, David A. McCarron
Journal: Annals of Internal Medicine (1983)

Dialogue Summaries1 May 1983Clinical Trials in Assessing the Effects of Nutrition on Blood PressureFriedrich C. Luft, M.D., David A. McCarron, M.D.Friedrich C. Luft, M.D.Search for more papers by this author, David A. McCarron, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-98-5-882_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRandomized clinical trials were advocated as the only reliable method to distinguish between therapies that are not overwhelmingly different. However, the application of such trials to assess the influence of dietary interventions in the treatment of hypertension is difficult. Alterations in dietary behavior are not easily achieved, and require a major degree of cooperation and enthusiasm on the part of the patient. Patient participation imparts a degree of self-selection, because lack of motivation will influence results. Nevertheless, the randomized design has been successfully used to address nutritional issues in hypertension. A cross-over design with random allocation was used in two... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Friedrich C. Luft, M.D.; David A. McCarron, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1983Volume 98, Issue 5_Part_2Page: 882-883KeywordsBehaviorBlood pressureClinical trialsHypertensionMotivationNutrition ePublished: 1 December 2008 Issue Published: 1 May 1983 PDF downloadLoading ...
AN EPIDEMIOLOGICAL STUDY OF RHINITIS (CORYZA) IN CALVES WITH SPECIAL REFERENCE TO PNEUMONIA
Authors: F. S. Jones, Ralph B. Little
Journal: The Journal of Experimental Medicine (1922)

During the month of November there occurred an outbreak of pneumonia among the calves in a large dairy. Thirty-two calves in one barn were exposed to the disease. Ten clinical cases developed. Two died of diffuse pneumonia. From these bovisepticus Group I organisms were obtained at autopsy. Four affected with pneumonia and eight other calves which failed to show symptoms of pneumonia developed a purulent rhinitis. From the nasal exudate of these cases Group I organisms were cultivated. The characteristic rhinitis was reproduced experimentally by brushing the nasal mucosa with a swab dipped in culture. Certain of the calves which suffered from the spontaneous rhinitis continued to carry the organisms in the nasal passages for periods as long as 121 days. After the first outbreak had subsided practically all calves introduced into this barn developed a milder type of rhinitis associated with organisms of Group II bovisepticus. 25 per cent of such calves continued to carry the organism on the nasal mucosa for periods of 50 to 73 days. It was possible to induce nasal infection in calves with pure cultures of this organism.
Unanticipated Admission to the Hospital Following Ambulatory Surgery
Authors: Barbara S. Gold, Deborah S. Kitz, John H. Lecky, John M. Neuhaus
Journal: JAMA (1989)

We conducted a case-control study to identify clinical and demographic risk factors for admission to the hospital following ambulatory surgery. Of 9616 adult patients who underwent ambulatory surgery at a university-affiliated hospital between 1984 and 1986, one hundred were admitted. The most common reasons for admission were pain (18), excessive bleeding (18), and intractable vomiting (17). The mean age (+/- SD) of patients who were admitted was 37 +/- 13 years, and 96% had American Society of Anesthesiologists' physical status scores of 1 or 2. Factors that were independently associated with an increased likelihood of admission were general anesthesia (odds ratio, 5.2), postoperative emesis (odds ratio, 3.0), lower abdominal and urologic surgery (odds ratio, 2.9), time in the operating room greater than 1 hour (odds ratio, 2.7), and age (odds ratio, 2.6). Our results indicate that the likelihood of unanticipated admission is related more to the type of anesthesia and surgical procedure rather than to the patient's clinical characteristics.
Diagnostic role of endoscopic ultrasound in selecting patients with early barrett neoplasia for endoscopic therapy
Authors: A. Barnabas, A. A. Bailey, B. Sgromo, N. Maynard, R. Marshall, B. Braden
Journal: Gut (2011)

<h3>Introduction</h3> Correct staging is essential in selecting patients with early oesophageal neoplasia for endoscopic therapy. We prospectively investigated the diagnostic value of endoscopic ultrasound (EUS) in predicting submucosal infiltration in early Barrett neoplasia. <h3>Methods</h3> Patients with histologically proven high grade dysplasia or intramucosal cancer who were referred for potential endoscopic treatment were included in this prospective study. All patients underwent EUS staging with radial echoendoscopic ultrasound probes (7.5 MHz). A (15 MHz) radial miniprobe was used to assess focal lesions in higher definition. <h3>Results</h3> 40 patients (31 men) were included. Thereof, 14 underwent oesophagectomy, 24 had endoscopic mucosal resection using the Duette Multiband device, 2 had both procedures. Final pathological results revealed 15 submucosa infiltrating cancers and 25 neoplastic lesions limited to the mucosa. One submucosal infiltration was missed by EUS. 5 intramucosal cancers were overstaged; 3 of these were within a stricture, one in an ulcer. For detecting submucosal invasion, EUS had a sensitivity of 93.3% (95%CI: 76.1 to 98.8%), a specificity of 84% (73.6 to 87.3%), a negative predictive value of 95.5% (83.7 to 99.2%), and a positive predictive value of 77.8% (63.4 to 82.3%). <h3>Conclusion</h3> Stricturing and ulceration may result in EUS overstaging of early oesophageal neoplasia, but this would render endoscopic therapy difficult also. Knowing these limitations EUS is useful in assessing suitability for endoscopic therapy.
Graduated compression stockings did not prevent deep venous thrombosis after stroke and increased skin complications
Authors: Allen J. Blaivas
Journal: Annals of Internal Medicine (2009)

Source Citation CLOTS Trials Collaboration. Effectiveness of thigh-length graduated compression stockings to reduce the risk of deep vein thrombosis after stroke (CLOTS trial 1): a multicentre, randomised controlled trial. Lancet. 2009;373:1958-65. 19477503