tbuckley/cabot-search huggingface dataset:
Abstract B50: Design, synthesis, and functional characterization of new cycle-peptides inhibitors for C-X-C chemokine receptor-4
Authors: L. Portella, M. Napolitano, C. Consales, M. N. Polimeno, C. D'Alterio, C. Arra, R. Vitale, P. Amodeo, S. De Luca, L. Monfregola, G. Castello, S. Scala
Journal: Clinical Cancer Research (2010)

Abstract Inhibition of the axis CXCR4/CXCL12 can affect tumor growth and metastases. Moreover, CXCR4 inhibition increases hematopoietic stem cell mobility in patients undergoing autologous transplantation for myeloma and non-Hodgkin lymphoma. Although several inhibitors were described neither one reached satisfactory efficacy, bioavailability and acceptable toxicity. To develop new CXCR4 inhibitors through a rationale design approach, comparative studies were undertaken evaluating the N-terminal structure of the ligand CXCL12 and v-MIP II, an inhibitory chemokine like produced by the herpes virus 8-Kaposi associated. A common amino acidic motif (RFF) was identified in both structures although in inverted orientation. Having as a core this small domain, a new library (20 units) of cycle-peptide molecules was generated. 20 units of cycle-peptide molecules were synthesized that consists of 5 and 7 amino-acid residues cycled by a S-S bridge designed to interact with the receptor CXCR4. The peptides were characterized for functionally CXCR4 interaction through: 1. inhibition of CXCR4 binding; 2. inhibition of migration CXCL12-induced; 3. inhibition of calcium CXCL12-induced; 4. Inhibition of P-Erk CXCL12-induced. Four peptides were identified as possible CXCR4 inhibitors. These four CXCR4 inhibitory peptides were further evaluated for the in vivo efficacy through inhibition of metastasis formation. B16 mouse melanoma cells transfected with CXCR4 were injected in the vein tail in C57 Bl mice and peptide treatment followed for 10 days. Dramatic reduction in number and size of lung metastases were registered in mice peptides-treated. Moreover, xenograft of human renal cancer cells SN12C-EGFP were subcutaneously injected and systemic peptides treatment followed for 10 days. Statistically significant decrease in tumor growth was showed in peptides treated mice. Taken together the data define three new CXCR4 inhibitory peptides, designed through innovative strategy, effective in “in vivo” deserving further development. Citation Information: Clin Cancer Res 2010;16(7 Suppl):B50
Privacy Beliefs and the Violent Family-Reply
Authors: Nancy S. Jecker
Journal: JAMA (1993)

<h3>In Reply.</h3> —I appreciate Dr Baughan's thoughtful letter and agree with the spirit of his suggestions for further elaborating the analysis of beneficence as it applies to the care of battered patients. My argument was not that justice should replace beneficence and nonmaleficence in the ethical analysis of domestic violence, but that the analysis should be broadened to include justice assessments. Baughan recommends that "the concept of beneficence be elaborated to consider effectiveness" and intimates that narrowly conceived interventions that focus exclusively on the individual patient may be ineffective and hence futile. The remedy then is caring not only for the patient, but for the family as a whole, including family members responsible for violence toward the patient. However, the idea of futility does not imply, as Baughan suggests, that an intervention does not produce an effect or change in the patient's condition. Rather, futility means that an intervention does
1-alpha-hydroxycholecalciferol for renal osteodystrophy.
Authors: A M Brownjohn, F J Goodwin, W Hately, F P Marsh, J L O'Riordan, S E Papapoulos
Journal: BMJ (1977)

Fourteen patients with renal osteodystrophy were treated for at least one year with 1-alpha-hydroxycholecalciferol (1-alpha-OHD3) in a dose varying from 1 microgram/week to 3 microgram/day. Plasma calcium and inorganic phosphorus concentrations increased significantly. The plasma alkaline phosphatase concentration fell in 11 of the 12 patients in whom it was initially raised and returned to normal in seven. Serum parathyroid hormone concentrations were initially raised in all patients, but they decreased significantly with treatment and became normal in eight patients within one year. The 10 patients with radiological abnormalities showed some improvement. Hypercalcaemia occurred in 11 patients, and necessitated a reduction in the dose of 1-alpha-OHD3 in some. 1-alpha-OHD3 was effective in reducing the biochemical and radiological abnormalities of renal osteodystrophy, but it should be used wtih care, and plasma calcium concentrations should be monitored.
Karate and karate injuries.
Authors: G. McLatchie
Journal: British Journal of Sports Medicine (1981)

The origins of karate and its evolution as a sport are described. Karate injuries tend to occur in three main areas: the head and neck, the viscera, and the limbs. Effective legislation controlling karate, which could help prevent injuries, is lacking at the moment and should be established. Recommendations for the prevention of injury include the introduction of weight classes, mandatory provision of protective equipment such as padded flooring, and the outlawing of certain uncontrollable methods of attack.
Postcaval Ureter
Authors: Raymond O. Olson, George Austen
Journal: New England Journal of Medicine (1950)

POSTCAVAL ureter, also known as "circumcaval" or "retrocaval" ureter, is a congenital anomaly, primarily of the vascular system, that has been recognized and reported with increasing frequency in the past ten years. However, since the original description of the first observed case by Hochstetter1 in 1893, the total of published cases to date is still less than 40. Thus, the condition may be considered among the more unusual and infrequent of clinical entities. Inasmuch as an accurate preoperative diagnosis was made in only 4 of the previously reported 17 cases found at surgical exploration, we consider it worth while to . . .
ED-02 * A SEER-MEDICARE DATA ANALYSIS OF ELDERLY GLIOBLASTOMA PATIENTS: TREATMENT PATTERNS, OUTCOMES AND COST
Authors: E. Burton, B. Ugiliweneza, S. Woo, S. Skirboll, M. Boakye
Journal: Neuro-Oncology (2014)

BACKGROUND: Elderly GBM patients may not tolerate 6 weeks of radiotherapy (RT) and concurrent temozolomide (TMZ). Treatments utilizing hypofractionated RT and/or chemotherapy are alternatives. In this study, we use a population based database to determine treatment patterns, cost and outcomes. METHODS: The surveillance epidemiology and end-result (SEER) Medicare linked database was used to identify 3759 patients aged > 66 with GBM diagnosed between 1997 and 2009. Patients were stratified by initial treatment after surgery into 6 groups: no treatment, standard RT +/- TMZ, hypofractionated RT +/- TMZ or TMZ alone. RESULTS: Median age of 3759 patients was 74 years (range 66-97). Forty-eight percent (n = 1818) received standard RT without TMZ, 10% (n = 386) standard RT with TMZ. Twenty-nine percent (n = 1094) no treatment after diagnostic surgery. Ten percent (n = 390) received hypofractionated RT without TMZ. One percent (n = 43) hypofractionated RT with TMZ and less than 1% (n = 28) TMZ alone. Median survival for all patients was 6 months (range 0-121). Those that received no therapy had a median survival of 2 months (range 0-89). Patients that received standard RT +/- TMZ had median survivals of 11 (range 2-56) and 9 months (range 1-121) respectively (p = 0.01). Compared to the no therapy group, patients that had hypofractionated RT +/- TMZ or TMZ alone had improved median survivals of 3 months (range 1-29, AHR 0.48; 95% CI, 0.36-0.66), 4 months (range 0-33, AHR 0.55; 95% CI, 0.49-0.62) and 6 months (range 1-24, AHR 0.43; 95% CI, 0.29-0.62) respectively. Median post-surgery total treatment cost for patients receiving hypofractionated RT +/- TMZ or TMZ alone was $50,634, $27,284 and $39,708 respectively. CONCLUSIONS: Hypofractionated RT +/- TMZ or TMZ alone appear to improve survival in elderly GBM patients deemed not suitable for standard RT/TMZ. In some cases TMZ alone may be a more cost effective therapy with similar survival.
Natural Allelic Variations in Glutathione Peroxidase-1 Affect Its Subcellular Localization and Function
Authors: Soumen Bera, Frank Weinberg, Dede N. Ekoue, Kristine Ansenberger-Fricano, Mao Mao, Marcelo G. Bonini, Alan M. Diamond
Journal: Cancer Research (2014)

Glutathione peroxidase 1 (GPx-1) has been implicated in the etiology of several common diseases due to the association between specific allelic variations and cancer risk. The most common among these variations are the codon 198 polymorphism that results in either a leucine or proline and the number of alanine repeat codons in the coding sequence. The molecular and biologic consequences of these variations remain to be characterized. Toward achieving this goal, we have examined the cellular location of GPx-1 encoded by allelic variants by ectopically expressing these genes in MCF-7 human breast carcinoma cells that produce undetectable levels of GPx-1, thus achieving exclusive expression in the same cellular environment. A differential distribution between the cytoplasm and mitochondria was observed, with the allele expressing the leucine-198 polymorphism and 7 alanine repeats being more cytoplasmically located than the other alleles examined. To assess whether the distribution of GPx-1 between the cytoplasm and mitochondria had a biologic consequence, we engineered derivative GPx-1 proteins that were targeted to the mitochondria by the addition of a mitochondria targeting sequence and expressed these proteins in MCF-7 cells. These cells were examined for their response to oxidative stress, energy metabolism, and impact on cancer-associated signaling molecules. The results obtained indicated that both primary GPx-1 sequence and cellular location have a profound impact on cellular biology and offer feasible hypotheses about how expression of distinct GPx-1 alleles can affect cancer risk. Cancer Res; 74(18); 5118-26. ©2014 AACR.
The Roentgen Diagnosis of Trauma
Authors: Ben L. Allen
Journal: JAMA (1965)

Although Dr. Zatzkin addresses this book chiefly to radiology residents, anyone who participates in the management of accident victims will find it of value. Hundreds of radiographs illustrate the volume, giving it the appearance of an atlas. On nearly every page there are several x-ray reproductions, all of excellent quality. For most of them there is a pedagogic, step-by-step analysis which helps the reader systematize his reading of films. In the sections on fractures and dislocations, line drawings portray the various types of injury and diagrammatically indicate the roentgen differences between them. The text consists of brief clinical discussions which include the usual mechanism of a particular injury and an outline for the most effective roentgenographic evaluation of the injured part. The text, the illustrations, and the x-ray photographs correlate well to analyze trauma affecting specific regions. The author devotes over one half of the book to skeletal injuries, including
Getting to the finish line with mTORC1-targeted therapy
Authors: Elizabeth Henske
Journal: Journal of Clinical Investigation (2012)

The mammalian target of rapamycin (mTOR) pathway is activated in the majority of human malignancies and thus seems a likely therapeutic target. However, this pathway is genetically complex, complicating studies using pharmacologic mTOR inhibitors. In this issue of the JCI, Hoshii et al. examined mice deficient in one of the mTOR effector complex proteins, Raptor, to elucidate the role of mTORC1 in leukemia. They convincingly demonstrate that Raptor deficiency, with consequent mTORC1 inhibition, blocks differentiation of leukemia cells and prolongs survival, but also allows a population of leukemia-initiating cells to persist in what appears to be a state of dormancy. Translating this new understanding into effective therapeutic strategies will require further study of the molecular mechanisms that underlie these processes.
Symptoms after accelerated immunisation.
Authors: M. E. Ramsay, M. Rao, N. T. Begg
Journal: BMJ (1992)

OBJECTIVE--To document the incidence of symptoms after accelerated immunisation with diphtheria-tetanus-pertussis vaccine. DESIGN--Controlled study of children immunised with adsorbed diphtheria-tetanus-pertussis vaccine at accelerated and standard schedules. SETTING--Colchester and north Hertfordshire. SUBJECTS--107 children scheduled to receive immunisation at 2, 3, and 4 months of age and 115 children scheduled to receive immunisation at 3, 4 1/2 to 5, and 8 1/2 to 11 months of age. MAIN OUTCOME MEASURES--Parentally recorded symptoms, axillary temperatures, and size of local redness and swelling at the injection site during the seven days after immunisation. RESULTS--In general symptoms occurred less frequently with the accelerated schedule. Proportions of parents reporting axillary temperatures greater than 37.2 degrees C or local redness or swelling greater than 2.5 cm after the third dose of vaccine were significantly reduced in the accelerated schedule group. CONCLUSION--Immunisation at 2, 3, and 4 months of age is likely to cause fewer reactions than immunisation at 3, 4 1/2 to 5, and 8 1/2 to 11 months of age.
Cyclic Adenosine Monophosphate Phosphodiesterase Type 4 Protects Against Atrial Arrhythmias
Authors: Cristina E. Molina, Jérôme Leroy, Wito Richter, Moses Xie, Colleen Scheitrum, Illkyu-Oliver Lee, Christoph Maack, Catherine Rucker-Martin, Patrick Donzeau-Gouge, Ignacio Verde, Anna Llach, Leif Hove-Madsen, Marco Conti, Grégoire Vandecasteele, Rodolphe Fischmeister
Journal: Journal of the American College of Cardiology (2012)
Preparation of Skin for Lumbar Puncture
Authors: Sidney Kahn
Journal: JAMA (1969)

<h3>To the Editor:—</h3> Harvey Bernard, MD, (<b>208</b>:1196, 1969), advised preparing the skin for lumbar puncture with a hexachlorophene-containing soap followed by benzalkonium chloride. James A. Visconti, PhD, and Donald Schneider RPh; then wrote you (<b>209</b>:2057, 1969) pointing out, quite properly, that soaps are anionic and consequently incompatible with cationic detergents such as benzalkonium chloride. They therefore advised removing the soap by thorough rinsing with water before applying the germicide. However, it is almost impossible to remove all soap with water. Water and soap constitute a colloidal suspension; if you rub the skin after what you consider a complete removal of soap with water, you can usually stir up a few more suds, sufficient to inactivate the cationic germicide. Alcohol and soap, on the other hand, are 100% soluble in one another. If you, therefore, expect a quaternary ammonium antiseptic to act effectively after preliminary preparation with soap, 70%
Loss of microRNA 122 expression in patients with hepatitis B enhances hepatitis B virus replication through cyclin G1-modulated P53 activity
Authors: Saifeng Wang, Lipeng Qiu, Xiaoli Yan, Wensong Jin, Yanzhong Wang, Lizhao Chen, Erjie Wu, Xin Ye, George F. Gao, Fusheng Wang, Yu Chen, Zhongping Duan, Songdong Meng
Journal: Hepatology (2011)

Hepatitis B virus (HBV) causes chronic infection in about 350 million people worldwide. Given the important role of the most abundant liver-specific microRNA, miR-122, in hepatic function and liver pathology, here we investigated the potential role and mechanism of miR-122 in regulating HBV replication. We found that miR-122 expression in liver was significantly down-regulated in patients with HBV infection compared with healthy controls, and the miR-122 levels were negatively correlated with intrahepatic viral load and hepatic necroinflammation. The depletion of endogenous miR-122 by its antisense inhibitor led to enhanced HBV replication, whereas overexpression of miR-122 by transfection of mimic or its expression vector inhibited viral production. We next identified cyclin G(1) as an miR-122 target from multiple candidate target genes that are involved in the regulation of HBV replication. Overexpression and knockdown studies both showed that cyclin G(1) regulated viral replication in HBV transfected cells. We also observed that cyclin G(1) expression was up-regulated in HBV-infected patients, and cyclin G(1) levels were inversely associated with miR-122 expression in liver tissues. Using coimmunoprecipitation, a luciferase reporter system, and electrophoretic mobility shift assay, we further demonstrated that cyclin G(1) specifically interacted with p53, and this interaction blocked the specific binding of p53 to HBV enhancer elements and simultaneously abrogated p53-mediated inhibition of HBV transcription. Finally, we show that miR-122 suppressed HBV replication in p53 wildtype cells but not in null isogenic cells.miR-122 down-regulates its target cyclin G(1) , and thus interrupts the interaction between cyclin G(1) and p53 and abrogates p53-mediated inhibition of HBV replication. Our work shows that miR-122 down-regulation induced by HBV infection can impact HBV replication and possibly contribute to viral persistence and carcinogenesis.
The Physician Payment Review Commission Report to Congress
Authors: Philip R. Lee
Journal: JAMA (1989)

THE PHYSICIAN Payment Review Commission has developed proposals to rationalize the pattern of payments to physicians by Medicare and to slow the rate of increase in program costs so that they are affordable to beneficiaries and taxpayers. It outlines these proposals in its 1989 report, submitted to Congress today. The Commission was created in 1986 to advise Congress on reform of the methods used by Medicare to pay physicians. The Congress expanded its charge in 1988 to include consideration of policies designed to slow the rates of increase in expenditures and utilization of physicians' services. Medicare is the nation's largest payer of medical bills in an industry that now accounts for more than 11% of the gross national product. Its expenditures have grown rapidly over the years, with spending for physicians' services being the fastest growing portion, rising an average of 15% a year. Taxpayers and beneficiaries pay for these
Just a Little Bit More About Drug Lag
Authors: Donald Kennedy
Journal: JAMA (1978)

IN AN article in the May 12, 1978, issue of<i>JAMA</i>, William Wardell, MD, PhD, delivered a lengthy rebuttal to an earlier article of mine on the so-called "drug lag." Because both sides of the argument have been stated in fairly extended form, I am satisfied to leave to the fair-minded reader the judgment of those issues in which we genuinely differ. I do, however, want to make a few points in an effort to limit the controversy to those areas in which real differences do exist. Dr Wardell begins his article with an extended series of quotations from articles, testimony, and other sources for the purpose of showing inconsistencies between my own stated views and those of my predecessors and colleagues at the Food and Drug Administration. These quotations and the speeches of mine that Dr Wardell cites should be compared carefully by anybody who thinks that there is really
Dialysis in Acute Kidney Injury — More Is Not Better
Authors: Joseph V. Bonventre
Journal: New England Journal of Medicine (2008)

Acute kidney injury is associated with morbidity and mortality rates of more than 50% in critically ill patients, despite the potential for recovery of renal function and many advances in medical management.1 To manage the care of patients with acute kidney injury, we must optimize their hemodynamic and volume status, correct metabolic abnormalities, provide adequate nutrition, and minimize progression of injury. Dialysis is often required, and critical factors to consider when designing a dialysis strategy for patients with acute kidney injury are determining the extent of dialysis and fluid removal, determining when to start dialysis, and selecting the most appropriate . . .
Career Intentions of MD/PhD Program Graduates—Reply
Authors: Dorothy A. Andriole, Alison J. Whelan, Donna B. Jeffe
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Enhanced Tumor Growth of Both Primary and Established Human and Murine Tumor Cells in Athymic Mice After Coinjection With Matrigel
Authors: R. Fridman, M. C. Kibbey, L. S. Royce, M. Zain, T. M. Sweeney, D. L. Jicha, J. R. Yannelli, G. R. Martin, H. K. Kleinman
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article Enhanced Tumor Growth of Both Primary and Established Human and Murine Tumor Cells in Athymic Mice After Coinjection With Matrigel Get access Rafael Fridman, Rafael Fridman Laboratory of Developmental Biology, National Institute of Dental Research, National Institutes of HealthBaltimore, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Maura C. Kibbey, Maura C. Kibbey Laboratory of Developmental Biology, National Institute of Dental Research, National Institutes of HealthBaltimore, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Leah S. Royce, Leah S. Royce Laboratory of Developmental Biology, National Institute of Dental Research, National Institutes of HealthBaltimore, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Mona Zain, Mona Zain Laboratory of Developmental Biology, National Institute of Dental Research, National Institutes of HealthBaltimore, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Thomas M. Sweeney, Thomas M. Sweeney Laboratory of Developmental Biology, National Institute of Dental Research, National Institutes of HealthBaltimore, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Douglas L. Jicha, Douglas L. Jicha Surgery Branch, Division of Cancer Treatment, National Cancer Institute), National Institutes of HealthBathesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar John R. Yannelli, John R. Yannelli Surgery Branch, Division of Cancer Treatment, National Cancer Institute), National Institutes of HealthBathesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar George R. Martin, George R. Martin Gerontology Research Center, National Institute on Aging, National Institutes of HealthBaltimore, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Hynda K. Kleinman Hynda K. Kleinman * Gerontology Research Center, National Institute on Aging, National Institutes of HealthBaltimore, Md. *Correspondence to : Hynda K. Kleinman. PhD. National Institute of Dental Research, Bldg 30, Rm 407, National Lnstitutes of Health, Bethesda, MD 20892 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 11, 5 June 1991, Pages 769–774, https://doi.org/10.1093/jnci/83.11.769 Published: 05 June 1991 Article history Received: 19 November 1990 Revision received: 28 February 1991 Accepted: 13 March 1991 Published: 05 June 1991