Prevention of Foscarnet Nephrotoxicity
Authors: G. Deray
Journal: Annals of Internal Medicine (1990)

Letters and Corrections15 August 1990Prevention of Foscarnet NephrotoxicityG. Deray, MD, C. Katlama, MD, E. Dohin, MDG. Deray, MD, C. Katlama, MD, E. Dohin, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-113-4-332_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors:Cytomegalovirus infections are a major cause of morbidity and mortality among immunocompromised patients (1). The most widely used drug therapy for treatment of severe infection with cytomegalovirus is ganciclovir (2). Progressive disease due to ganciclovir-resistant cytomegalovirus has, however, been recently reported (3). Moreover, ganciclovir-induced neutropenia is very often a problem in patients treated with zidovudine (AZT). Phosphonoformate (foscarnet) is a pirophosphate analogue that inhibits the DNA polymerase of influenza viruses and acts against the reverse transcriptase of retroviruses (4). Moreover, foscarnet has been shown to be effective in a patient with the acquired immunodeficiency syndrome (AIDS) and...References1. BachBagwellKnappDavisHedstroms MSNKP. 9 (1-3-Dihydroxy-2-propoxymethyl) guanine for cytomegalovirus infections in patients with the acquired immunodeficiency syndrome. Ann Intern Med. 1985,103:381. LinkGoogle Scholar2. EriceChouBironStanatBalfourJordan ASKSHM. Progressive disease due to ganciclovir resistant cytomegalovirus in immuno-compromised patients. N Engl J Med. 1989;320:289-93. CrossrefMedlineGoogle Scholar3. HelgstrandErikssonJohansson EBN. Phosphonoformate. A new antiviral compound. Science. 1978;201:819-21. CrossrefMedlineGoogle Scholar4. ChatisMillerScragerCrumpagker PCLC. Successful treatment with foscarnet of an acyclovir resistant mucocutaneous infection with herpes simplex virus in a patient with acquired immunodeficiency syndrome. N Engl J Med. 1989;320:297-300. CrossrefMedlineGoogle Scholar5. DerayMartinezKatlama GFC. Foscarnet nephrotoxicity. Mechanism, incidence and prevention. Am J Nephrol. 1989;9:316-32. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Hôpital Pitie-Salpetriere 75013 Paris, France PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPediatric onco-nephrology: time to spread the wordMedication-Induced Nephrotoxicity in ChildrenMedication-Associated Glomerular DiseaseMedication-Associated Glomerular DiseaseCombining field effect scanning electron microscopy, deep UV fluorescence, Raman, classical and synchrotron radiation Fourier transform Infra-Red Spectroscopy in the study of crystal-containing kidney biopsiesAntiretroviral Medications: Adverse Effects on the KidneyNephrotoxinsNephrotoxicity as a cause of acute kidney injury in childrenAntiviral agentsAntiviral Therapy For HIV Patients With Renal InsufficiencyDrug-Induced Renal Failure in the ICUDrugs and the retinaAntiviral agentsCircumventing Drug InteractionsAntiviral Therapy For HIV Patients With Renal InsufficiencyAntiviral Therapy For HIV Patients With Renal InsufficiencyAntiviral agentsFoscarnet alters antidiuretic hormone-mediated transportLes pneumonies à cytomégalovirusEsophageal infections: Risk factors, presentation, diagnosis, and treatmentCytomegalovirus infection in acquired immune-deficiency syndromeThe Control of Cytomegalovirus Infection: ChemotherapySystemic antiviral drugs used in ophthalmologyFoscarnet and Ganciclovir in the treatment of CMV retinitis in AIDS patients: A randomised comparisonTreatment of Herpesvirus Infections in Hiv-Infected IndividualsTreatment of CMV RetinitisAntiviral Agents 15 August 1990Volume 113, Issue 4Page: 332-332KeywordsAIDSCytomegalovirus infectionDNA polymeraseDrug therapyInfluenza virusesMorbidityMortalityNeutropeniaProgressive diseasesRetroviruses ePublished: 1 December 2008 Issue Published: 15 August 1990 PDF downloadLoading ...