tbuckley/cabot-search huggingface dataset:
Right ventricular adaptations and arrhythmias in amateur ultra-endurance athletes
Authors: Caroline Rimensberger, Frederik Carlen, Nicolas Brugger, Christian Seiler, Matthias Wilhelm
Journal: British Journal of Sports Medicine (2013)

Objective Ultra-endurance sports are becoming increasingly popular in middle-aged amateur athletes. Right ventricular (RV) arrhythmogenic remodelling has been described in high-level endurance athletes, like professional cyclists. The clinical relevance for amateurs is unknown. Design We investigated male amateur runners of the 2011 Grand Prix of Bern, a popular 10-mile race in Switzerland. Participants were stratified according to their former participations in long-distance competitions: active controls (leisure-time runners), marathon runners and ultra-endurance athletes (78 and 100 km runners, long-distance triathletes). RV function and morphology were assessed by echocardiography, including two-dimensional speckle tracking. Primary endpoint was RV global strain. Ventricular ectopy was assessed by 24 h ambulatory Holter monitoring. Results were adjusted for lifetime training hours. Results 97 normotensive athletes were included in the final analysis. The mean age was 42±8 years. Compared with active controls and marathon runners, ultra-endurance athletes had significantly more lifetime training hours and participated more often in competitions. Groups showed no differences with regard to RV global strain (–21.8±2.9 vs −23.3±2.8 vs −21.7±2.3%; p=0.973) and RV end-diastolic area (22.1±2.9 vs 22.9±4.2 vs 23.2±3.5 cm 2 ; p=0.694). The number of premature ventricular contractions (PVCs) was weakly associated with the RV size (r=0.208; p=0.042). Overall ventricular ectopy was low (0–486 PVCs/24 h) and equally distributed between the groups. Conclusions In our small sample of amateur athletes, long-term ultra-endurance sport practice was not associated with RV dysfunction or complex ventricular arrhythmias.
Molecular Therapies for Colorectal Cancer Metastatic to the Liver
Authors: Philipp Mayer-Kuckuk, Debabrata Banerjee, Nancy Kemeny, Yuman Fong, Joseph R. Bertino
Journal: Molecular Therapy (2002)

Colorectal cancers are the fourth most commonly diagnosed cancers and will account for over 56,000 deaths in the United States in 2002. A majority of patients with advanced colorectal cancer develop liver metastases during the course of their disease. Treatment of colorectal cancer metastatic to the liver by surgery or chemotherapy is limited and most patients succumb to their disease. Therefore, a broad spectrum of novel treatments, including innovative molecular therapies such as gene and immunotherapy or replication-competent viral therapy, is under preclinical investigation and several clinical trials are in progress. Here we review molecular therapies for colorectal cancer metastatic to the liver. Colorectal cancers are the fourth most commonly diagnosed cancers and will account for over 56,000 deaths in the United States in 2002. A majority of patients with advanced colorectal cancer develop liver metastases during the course of their disease. Treatment of colorectal cancer metastatic to the liver by surgery or chemotherapy is limited and most patients succumb to their disease. Therefore, a broad spectrum of novel treatments, including innovative molecular therapies such as gene and immunotherapy or replication-competent viral therapy, is under preclinical investigation and several clinical trials are in progress. Here we review molecular therapies for colorectal cancer metastatic to the liver.
Isolated Failure of Autonomic Noradrenergic Neurotransmission
Authors: David Robertson, Michael R. Goldberg, Jack Onrot, Alan S. Hollister, Ron Wiley, John G. Thompson, Rose Marie Robertson
Journal: New England Journal of Medicine (1986)

AUTONOMIC disorders are usually characterized by widespread abnormalities in both the sympathetic and the parasympathetic systems; this is true whether the autonomic disorder is associated with central neurologic deficits or is confined to the peripheral autonomic nervous system.1 2 3 Detailed testing can usually identify the extent of the autonomic neuronal damage,4 , 5 but it is uncommon for the abnormality to be localized to a single class of neurons. We have recently evaluated a young woman with autonomic failure in whom the pathophysiologic features of the disorder suggest an isolated failure in the β-hydroxylation of dopamine in the peripheral noradrenergic nerves.Case Report . . .
Lincomycin Hydrochloride: Clinical and Laboratory Studies
Authors: A. M. Geddes, R. A. Sleet, J. McC. Murdoch
Journal: BMJ (1964)

Lymphoma in Northern Nigeria-Berry MEDIALTISJHRNAL preponderance of cases in the southern part of this region, would seem to indicate that the relatively cooler and dryer climate of Northern Nigeria is a less favourable environment for the lymphoma syndrome.However, the apparent incidence of disease in an underdoctored area often depends on the incidence of doctors and on their medical interests.A further analysis of the total biopsy figures in this region during 1963-4 reveals CHAD KADUNA C3) KONTAGORA (I) * ( tf ~~~~~~~~~AKKI DA ( 2) PANKSHIN (I) 0 HUMAN (3) MINNA (I) BAMBUR(3) LOKOJ2;;) OWUKARI (I) LAGOS i s _ _ MKAR (2) FIG.3.-Towns from which cases of Burkitt's tumour came.The number of cases from each town is shown in parentheses.that 923 specimens were received from hospitals south of the Garkida-Kaduna-Kontagora line, and only 247 were from north of this line.Moreover, of the 126 children on whom biopsy was made, only 23 came from hospitals north of Kaduna.During the same year 367 biopsies were examined at the Kano Pathology Laboratory.Twenty were from patients of 15 years and under, and 10 of these demonstrated malignant tumours.One, a tumour of jaw in a boy of 31 years, was said to be a lymphosarcoma.It seems reasonable to suppose that this could be another case of Burkitt's tumour (F.Vivarelli, personal communication, 1964).The six other malignant lymphomata of children seen at Kaduna during the year consisted of three lymphosarcomas, two reticulum-cell sarcomas, and one Hodgkin's disease, all involving lymph nodes. SummaryThe lymphoma syndrome undoubtedly occurs in the Northern Region of Nigeria.Eighteen cases were seen at the Kaduna Regional Pathology Laboratory during the year 1963-4, this representing about 50 % of all malignant tumours of child- hood.All the cases came from the southern part of the Northern Region, although one possible additional case was seen at Kano Pathology Laboratory, which receives specimens from the near-by hospitals in the northern part of this region.
Emergence of Extensive Drug Resistance during Treatment for Multidrug-Resistant Tuberculosis
Authors: Helen S. Cox, Caterina Sibilia, Silke Feuerriegel, Stobdan Kalon, Jonny Polonsky, Atadjan K. Khamraev, Sabine Rüsch-Gerdes, Clair Mills, Stefan Niemann
Journal: New England Journal of Medicine (2008)

This report from Uzbekistan describes the development of fluoroquinolone-resistant and extensively drug-resistant tuberculosis during second-line treatment for multidrug-resistant (MDR) tuberculosi...
Abstract 1279: Serum biochemistry and microarray analysis of liver and colonic mucosa in LETO and diabetic OLETF rats treated with 20% caloric restriction and high-fat diet.
Authors: Keisuke Izumi, Chie Takasu, Tetsuyuki Takahashi, Hisanori Uehara
Journal: Cancer Research (2013)

Abstract We showed recently that diabetic and mildly obese Otsuka Long-Evans Tokushima Fatty (OLETF) rats were more susceptible to azoxymethane-induced carcinogenesis than control Long-Evans Tokushima Otsuka (LETO) rats, and carcinogenesis was inhibited by 20% caloric restriction (CR) and enhanced by high-fat diet (HFD, control diet with 10% safflower oil). To elucidate the mechanism of cancer susceptibility, we performed serum biochemical analysis and microarray analysis of the liver and colonic mucosa. Male LETO and OLETF rats were given control diet, 20% CR diet or HFD for 5 weeks, and euthanized at 24 weeks of age (n=5, respectively). In both strains, blood glucose, serum triglyceride, total cholesterol, insulin and leptin levels decreased by 20% CR, and increased by HFD. Steatosis of hepatocytes in OLETF rats was ameliorated by 20% CR and enhanced by HFD. Microarray analysis of the liver showed that 20% CR up-regulated metallothionein 1A gene, and down-regulated heat shock 105kDa/110kDa protein 1 (Hsph1) and heat shock 70kDa protein 1B (Hspa1b) genes in both strains. There were no histological differences in the colonic mucosa in both strains and the effect of the dietary difference was not found. Microarray analysis of the colonic mucosa showed that 20% CR down-regulated Hsph1 and Hspa1b genes, and HFD up-regulated fatty acid binding protein 2 in both strains. These data suggest that hyperinsulinemia, hyperlipidemia and oxidative stress by overnutrition exert significant role in cancer susceptibility in OLETF rats. Citation Format: Keisuke Izumi, Chie Takasu, Tetsuyuki Takahashi, Hisanori Uehara. Serum biochemistry and microarray analysis of liver and colonic mucosa in LETO and diabetic OLETF rats treated with 20% caloric restriction and high-fat diet. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1279. doi:10.1158/1538-7445.AM2013-1279
A COMPARATIVE STUDY OF CERTAIN ACTIONS OF ADRENALIN IN THE CAT AND THE RABBIT
Authors: Thomas Stotesbury Githens
Journal: The Journal of Experimental Medicine (1917)

The present investigation brought out the facts that the pupil of the cat is little affected by instillation of adrenalin, but shows, nevertheless, a greater responsiveness to adrenalin when given intravenously than does that of the rabbit, and that the duration of the dilatation effected by intravenous injection is, on the contrary, longer in the rabbit. In regard to the vasoconstricting effect of adrenalin when administered intravenously, it was found that the intensity as well as the duration of the rise of blood pressure was greater in the rabbit than in the cat.
Abstract 2232: Computational modeling reveals druggable cavities at the MKK3 and p38 protein interaction interface.
Authors: Andrei A. Ivanov, Satra Nim, Yuhong Du, Haian Fu
Journal: Cancer Research (2013)

Abstract Mitogen-activated protein kinase (MAPK) cascades play vital roles in transmitting regulatory signals that control diverse physiological processes. Among them, MAPK p38 is critical for immune response, cell survival, and differentiation. The importance of the MKK3-p38 pathway in the development of cancer, asthma, inflammatory and other diseases is well-established. Accordingly, many inhibitors of p38 have been developed, some of which have entered clinical trials. Our research indicates that the MKK3-p38 interaction, upstream of p38 itself, forms a critical node in a network of protein-protein interactions (PPI) important for cell growth. Thus, pathway blockers that target the MKK3-p38 PPI interface may have therapeutic potential beyond p38 kinase inhibitors. To discover MKK3-p38 PPI inhibitors, we took an experimentally-based computational approach, which led to the identification of a PPI interface and molecular tools for therapeutic interrogation. Our biological studies revealed a short inhibitory peptide located at the N-terminus of p38, which effectively disrupts the MKK3-p38 interaction in vitro and in vivo via its binding to MKK3. In this study, the structural organization of MKK3-p38 complex and the molecular mechanisms of peptide binding were investigated with computational modeling methods. We constructed the first model of MKK3, its complex with MAPK p38, and binding of the short inhibitory peptide to the MKK3 surface. Using this model, we have proposed several potentially druggable cavities on the molecular surfaces of both the MKK3 and p38 kinases. We found that the p38 N-terminal peptide can occupy the same cavity on the MKK3 surface as the p38 phosphorylation loop. Further, we have proposed the peptide residues playing the most important role in MKK3 binding. Overall, our data provide a basis for the rational design and screening for small molecule inhibitors of the MKK3-p38 interaction as regulators of the p38 signaling pathway. Citation Format: Andrei A. Ivanov, Satra Nim, Yuhong Du, Haian Fu. Computational modeling reveals druggable cavities at the MKK3 and p38 protein interaction interface. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2232. doi:10.1158/1538-7445.AM2013-2232
Use of Preoxygenation with the Laryngeal Mask Airway in Critical Care
Authors: Luiz F. Souza, Ana C. Pereira, Paulo S. Lavinas
Journal: American Journal of Respiratory and Critical Care Medicine (2007)

Positive pressure ventilation (PPV) greatly benefits critically ill patients, but frequently endotracheal intubation is required. The recent article on rapid-sequence intubation (RSI) preceded by noninvasive ventilation (NIV) by Baillard and colleagues may have a tremendous impact on practice (1). RSI was meant to reduce pulmonary aspiration in surgical patients. As little as 30 ml of gastric fluids predisposes the patient to pulmonary aspiration. Thus, supraglottic ventilation is usually avoided (2). In addition, spontaneous vomiting and regurgitation are common during acute illness as predisposing factors for surgeryrelated aspiration. Even trained anesthesiologists using collapsible flow-filled bags coupled to adjustable pressure relief valves cannot always avoid gastric inflation in healthy patients. Thus, early sealing of the trachea is always warranted. While 1 per 2,000–7,000 adults undergoing general anesthesia aspirates gastric contents, laborious intubations in the critical care setting are associatedwithmuch higher rates of regurgitation and aspiration (3). RSI is not a rigid technique but an evolving concept. Recent modifications have included administration of opioids, use of video devices, and omission of cricoid pressure, but avoidance of PPVwas considered for over five decades as dogma. Although the benefits of PPV are unquestionable, facial mask PPV is not necessarily safe. The data to support delivering pressures of 15 cm H2O were extrapolated from articles citing work with 9 asphyxiated and 4 fresh stillborn babies as well as 60 anesthetized adults (4, 5). An intermediate approach to preoxygenation in many critical care patients would be the laryngeal mask airway (LMA). Its introduction spares laryngoscopy and demands less pharmacological modulation, resulting in a smooth induction. Initially, the classic LMA was an alternative to the face mask, but it has proved to be an excellent protection to the trachea and an instant bridge to cuffed tubes (6). Like others, we have used these versatile devices in trauma and resuscitation, and in critical care patients. The LMA family also excels in the case of accidental extubations and many difficult airway situations. The LMA ProSeal (LMA North America, Inc., San Diego, CA) seals the airway even more effectively than the classic LMA and has an extra lumen to use in gastric suctioning. Using pressures of up to 20 to 30 cmH2O, this model helps to overcome low compliance lungs. Future studies should define the safety profile of PPV RSI in critical care patients. A recent audit on perioperative pulmonary aspiration disclosed both lowmorbidity (1/16, 573) andmortality (1/99, 441) whenPPVRSIwas used (3).Meanwhile, practitioners should keep in mind that the technique proposed is an attractive intervention to ameliorate severe hypoxia in selected patients.
The hidden curriculum in undergraduate medical education: qualitative study of medical students' perceptions of teaching
Authors: Heidi Lempp, Clive Seale
Journal: BMJ (2004)

To study medical students' views about the quality of the teaching they receive during their undergraduate training, especially in terms of the hidden curriculum.Semistructured interviews with individual students.One medical school in the United Kingdom.36 undergraduate medical students, across all stages of their training, selected by random and quota sampling, stratified by sex and ethnicity, with the whole medical school population as a sampling frame.Medical students' experiences and perceptions of the quality of teaching received during their undergraduate training.Students reported many examples of positive role models and effective, approachable teachers, with valued characteristics perceived according to traditional gendered stereotypes. They also described a hierarchical and competitive atmosphere in the medical school, in which haphazard instruction and teaching by humiliation occur, especially during the clinical training years.Following on from the recent reforms of the manifest curriculum, the hidden curriculum now needs attention to produce the necessary fundamental changes in the culture of undergraduate medical education.
Oligoarginine-linked polymers as a new class of penetration enhancers
Authors: Shinji Sakuma, Masaya Suita, Yoshie Masaoka, Makoto Kataoka, Noriko Nakajima, Norihiro Shinkai, Hitoshi Yamauchi, Ken-ichiro Hiwatari, Hiroyuki Tachikawa, Ryoji Kimura, Shinji Yamashita
Journal: Journal of Controlled Release (2010)
Endosonographic detection of dumbbell-shaped jejunal GIST using double balloon enteroscopy
Authors: N. Matsui, K. Akahoshi, Y. Motomura, M. Kubokawa, M. Kimura, J. Ohuchi, K. Honda, A. Murata, S. Endoh, M. Miyazaki, M. Oya, S. Nakano, K. Nakamura
Journal: Endoscopy (2008)

The introduction of double balloon enteroscopy (DBE) into clinical practice has enabled us to examine lesions, even those located in the jejunum [1]. DBE has also been reported to be useful for the treatment of bleeding jejunal lesions [2]. We report a case of gastrointestinal stromal tumor (GIST) of the jejunum, a precise preoperative diagnosis of which was made with DBE.
Regulatory bodies can discipline expert witnesses
Authors: Clare Dyer
Journal: BMJ (2006)

Doctors and other expert witnesses in court cases have no immunity from disciplinary action by their regulatory body, the Court of Appeal ruled last week in London.

Three judges, headed by the master of the rolls, Sir Anthony Clarke, overturned a High Court ruling last February that extended expert witnesses' immunity from civil action to cover disciplinary action by regulatory bodies—unless a judge made a complaint ( BMJ 2006;332: 439).

The case began in …
Faith and Healing
Authors: Linda Gundersen
Journal: Annals of Internal Medicine (2000)

Currents18 January 2000Faith and HealingLinda GundersenLinda GundersenSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-2-200001180-00102 SectionsAboutFull Text ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Studies suggesting that church going, religious beliefs, and prayer can improve morbidity and mortality have increasingly received attention in medical journals and the general media. One study at Duke University concluded that steady church attendance improves health and prolongs life (J Gerontol A Biol Sci Med Sci. 1999; 54:M370-6). Some authorities, however, believe that researchers often use flawed methods to study the relation between health and religion. They point out that the cause-and-effect relations are frequently unclear because religious persons, who are often defined as regular attendees of worship services, are in general already healthier than nonreligious persons. In fact, ... Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySpirituality in general practice: a qualitative evidence synthesisItalian validation of the Brief Rcope scale for religious copingThe biochemistry of beliefComparison of middle-age and young women inpatients with eating disordersProfile of 50 Women with Midlife-Onset Eating DisordersTreatment Responses of Inpatient Eating Disorder Women with and without Co-occurring Obsessive-compulsive DisorderPsychiatric Comorbidities of Female Inpatients With Eating DisordersManagement Strategies for Patients With Amyotrophic Lateral Sclerosis From Diagnosis Through DeathThe prevalence, patterns of usage and people's attitude towards complementary and alternative medicine (CAM) among the Indian community in Chatsworth, South AfricaThe Importance of Prayer for Mind/Body HealingSpirituality and MedicineImportance of Faith on Medical Decisions Regarding Cancer CareTowards clarification of the meaning of spiritualityNursing the spirit: the Framework of Systemic OrganizationReligious Involvement, Spirituality, and Medicine: Implications for Clinical PracticeAndere MaßnahmenShould Physicians Prescribe Religious Activities? 18 January 2000Volume 132, Issue 2Page: 169-172KeywordsAlcoholicsAlcoholismBehaviorCardiac care unitDeath ratesHealth careHealth economicsPatientsStrokeSurgery ePublished: 15 August 2000 Issue Published: 18 January 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.Loading ...
THE CORRELATION BETWEEN VENTRICULAR FUNCTION AND THE QUANTITATIVE ANALYSIS OF EXERCISE AND REST THALLIUM MYOCARDIAL SCINTIGRAPHY
Authors: Michael L. Goris, Joseph Hung, Johan Vanhaecke, Jean-Louis Barat, Jack H. Paldi, Robert F. DeBusk
Journal: Clinical Nuclear Medicine (1981)

Goris, Michael L.; Hung, Joseph; Vanhaecke, Johan; Barat, Jean-Louis; Paldi, Jack H.; DeBusk, Robert F. Author Information
Professor Hamburger on renal transplantation
Authors: J. Hamburger
Journal: JAMA (1971)

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