tbuckley/cabot-search huggingface dataset:
Disclosure of genetic risk for Alzheimer disease did not increase anxiety or depression in asymptomatic adults
Authors: Jogenananda Pramanik
Journal: Annals of Internal Medicine (2009)

ACP Journal Club17 November 2009Disclosure of genetic risk for Alzheimer disease did not increase anxiety or depression in asymptomatic adultsJogenananda Pramanik, MD, MBBSJogenananda Pramanik, MD, MBBSAllianze College of Medical Sciences, Palau Penang, Malaysia (J.P.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-151-10-200911170-02009 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationGreen RC, Roberts JS, Cupples LA, et al. Disclosure of APOE genotype for risk of Alzheimer’s disease. N Engl J Med. 2009;361:245−54. https://pubmed.ncbi.nlm.nih.gov/19605829Clinical Impact RatingsGIM/FP/GP: Genetics: Geriatrics: Neurology: References1 Weiss D, Marmar C. The Impact of Event Scale–Revised. In: Wilson J, Keane T, eds. Assessing Psychological Trauma and PTSD. New York: Guildford; 1997. Google Scholar2 Butow PN, Lobb EA, Meiser B, Barratt A, Tucker KM. Psychological outcomes and risk perception after genetic testing and counselling in breast cancer: a systematic review. Med J Aust. 2003;178:77-81. [PMID: 12526728] Google Scholar Author, Article, and Disclosure InformationAuthors: Jogenananda Pramanik, MD, MBBSAffiliations: Allianze College of Medical Sciences, Palau Penang, Malaysia (J.P.)This article was published at Annals.org on 3 November 2009. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 17 November 2009Volume 151, Issue 10Page: JC5-9KeywordsAlzheimer diseaseAnxietyChildrenDisabilitiesDisclosureForecastingGenetic counselingGenetic diseasesGeneticsGenotyping ePublished: 17 November 2009 Issue Published: 17 November 2009 Copyright & PermissionsCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Elevated Atypical Creatine Kinases
Authors: Stephen L. Chastain, Catherine H. Ketchum, William E. Grizzle
Journal: JAMA (1986)

To the Editor.—  We read with interest the CASE REPORT by Gibson and Schnur 1 concerning an atypical creatine kinase (CK) in a patient with adenocarcinoma of the lung. The CK profile was unusual in that there was a persistent intermediately migrating electrophoretic band that was initially confused with CK-MB and accounted for the majority of the CK activity. We wish to offer two possible explanations for the atypical CK observed by Gibson and Schnur that coincide with our experimental observations.   Macro CK type 1 is a term used to designate some atypical electrophoretic CK bands occasionally found migrating between CK-MM and CK-MB. Macro CK type 1 is composed of a CK isoenzyme, usually CK-BB or possibly CK-MM, complexed to another serum protein. The isoenzyme is usually complexed with IgG, but IgA and β-lipoprotein complexes have also been identified. We have found that the addition of antiserum to CK-BB to
Ewen Crighton Bramwell
Authors: David J D Farrow
Journal: BMJ (2006)

​FormerFormer general practitioner South Holmwood, Surrey (b Manchester 1930; q Cambridge/London 1955; MBE, DObst RCOG), d 5 July 2005.



Figure 1



After house jobs and service in the Royal Navy Ewen became a general practitioner in South Holmwood, Surrey, in 1962. He was part time consultant medical adviser to Surrey Family Health Services Authority from 1993 to 1996 and was part time GP adviser to South Thames (West) Regional Health Authority from 1994 to 1995. Ewen also had a medicopolitical career, serving on many local and national committees. He was an active member of BMA Council and sat on the General Medical Services Committee. His desire to help those of his profession and their families who fell on hard times was channelled through the work he did for the Cameron Fund. Ewen was made a fellow of the BMA. He leaves a wife, June, and three children.
Outcome and prognostic markers in severe drug-induced liver disease
Authors: Einar Björnsson, Rolf Olsson
Journal: Hepatology (2005)

The combination of high aminotransferases (hepatocellular injury) and jaundice has been reported to lead to a mortality rate of 10% to 50% for different drugs, a phenomenon known as "Hy's rule." However, Hy's rule has never been validated, and limited data exist on predictors for outcome in hepatocellular and other forms of drug-induced liver disease. All reports of suspected hepatic adverse drug reactions received by the Swedish Adverse Drug Reactions Advisory Committee (1970-2004) were reviewed. Cases with bilirubin levels 2 or more times the upper limit of normal (ULN) were analyzed. A total of 784 cases were retrieved-409 with hepatocellular injury, 206 with cholestatic injury, and 169 with mixed liver injury. The mortality/transplantation rate was 9.2%, and bilirubin (median 18.7 x ULN [IQR 12.6-25]; range 4.5-42) was higher (P < .0001) in the deceased/transplant recipients compared with the surviving patients (median 5.5 x ULN [IQR 3.3-9.5]; range 2.0-38). A total of 7.8% with cholestatic and 2.4% with a mixed pattern died. The mortality rate in hepatocellular injury for different drugs varied from 40% (6 of 15) for halothane to 0% (0 of 32) for erythromycin, in total 12.7%. Using logistic regression analysis, age, aspartate aminotransferase (AST) and bilirubin were found to independently predict death or liver transplantation in the hepatocellular group, whereas among patients with cholestatic/mixed liver injury, bilirubin was the only independent predictor. In conclusion, hepatocellular jaundice has a high but variable mortality rate, depending on the drug involved. The AST and bilirubin levels are the most important predictors of death or liver transplantation.
Comparison of parent knowledge, therapy utilization and severity of atopic eczema before and after explanation and demonstration of topical therapies by a specialist dermatology nurse
Authors: M.J. Cork, J. Britton, L. Butler, S. Young, R. Murphy, S.G. Keohane
Journal: British Journal of Dermatology (2003)

Journal Article Comparison of parent knowledge, therapy utilization and severity of atopic eczema before and after explanation and demonstration of topical therapies by a specialist dermatology nurse Get access M.J. Cork, M.J. Cork Paediatric Dermatology Clinic, Sheffield Children's Hospital, Sheffield S10 2TH, U.KDermatology–Biomedical Genetics, Division of Genomic Medicine, andRupert Hallam Department of Dermatology, Royal Hallamshire Hospital, Sheffield S10 2JF, U.K M.J.Cork. E‐mail: m.j.cork@sheffield.ac.uk Search for other works by this author on: Oxford Academic Google Scholar J. Britton, J. Britton Department of Dermatology, The General Infirmary at Leeds, Leeds LS1 3EX, U.K Search for other works by this author on: Oxford Academic Google Scholar L. Butler, L. Butler Rupert Hallam Department of Dermatology, Royal Hallamshire Hospital, Sheffield S10 2JF, U.K Search for other works by this author on: Oxford Academic Google Scholar S. Young, S. Young Paediatric Dermatology Clinic, Sheffield Children's Hospital, Sheffield S10 2TH, U.K Search for other works by this author on: Oxford Academic Google Scholar R. Murphy, R. Murphy Department of Dermatology, Chesterfield and North Derbyshire Royal Hospital, Calow, Chesterfield S44 5BL, U.K Search for other works by this author on: Oxford Academic Google Scholar S.G. Keohane S.G. Keohane Milford Dermatology Unit, St Mary's Hospital, Portsmouth PO3 6AD, U.K Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 149, Issue 3, 1 September 2003, Pages 582–589, https://doi.org/10.1046/j.1365-2133.2003.05595.x Published: 01 September 2003 Article history Accepted: 08 March 2003 Published: 01 September 2003
JOINT PHARMACOLOGIC INVESTIGATIONS BY THE AMERICAN MEDICAL ASSOCIATION AND THE AMERICAN PHARMACEUTICAL ASSOCIATION.
Authors: H. H. RUSBY
Journal: JAMA (1896)

When one examines the pharmacologic portions of the many ponderous volumes composing the index to the Surgeon-General's library, and those of the Index Medicus, by which the former has been succeeded, remembering that a very large part of pharmaceutic literature is not here represented, the conviction is forced upon him that our knowledge of the practical utility of medicinal plants is small beyond all reasonable comparison with the amount of time that has been bestowed upon their study. This fact is not difficult to explain, at least in part. It is largely due to the method, or rather want of method which has prevailed, by which partial investigations have been made by individuals without regard to their relation to the complementary parts, these being left undone, the part performed remaining unutilized and becoming finally buried and forgotten. This neglect has been made farther operative by the habit of investigators of
CD8+ dermal T cells from a sulphamethoxazole-induced bullous exanthem proliferate in response to drug-modified liver microsomes
Authors: M. HERTL, F. JUGERT, H.F. MERK
Journal: British Journal of Dermatology (2006)

There is evidence that T lymphocytes play a critical role in the pathogenesis of drug‐induced bullous exanthems. Sulphonamides are known to be among the most frequent aetiological agents in these severe drug‐induced cutaneous hypersensitivity reactions. Several studies indicate that cytochrome P450‐dependent metabolites of sulphonamides act as the nominal allergens. A 70‐year‐old woman with a severe blistering exanthem caused by cotrimoxazole (sulphamethoxazole and trimethoprim) was studied. We employed an in vitro approach to determine whether cytochrome P450‐dependent enzymes activated drug‐specific T lymphocytes from this patient. Immunohistochemical analysis of involved skin revealed a majority of epidermal CD8+ T lymphocytes, whereas the dermal infiltrate was composed of both CD4+ and CD8+ T cells. Dermal T lymphocytes isolated from lesional skin proliferated in response to sulphamethoxazole, but not to trimethoprim, in the presence of autologous mononuclear cells used as antigen‐presenting cells. The antigen‐specific response of sulphamethoxazole‐specific T cells was significantly augmented in the presence of murine liver microsomes with P450‐dependent catalytic activities. Our observations suggest that some cutaneous hypersensitivity reactions to sulphamethoxazole are due to drug‐specific T lymphocytes. Cytochrome P450‐dependent enzymes may play a critical role in the formation of the nominal antigen, which is recognized by antigen‐specific T cells.
Partnerships in Healthcare: Transforming Relational Processes
Authors: Robert M. Arnold
Journal: Annals of Internal Medicine (1999)

Medical Writings: Book Notes5 January 1999Partnerships in Healthcare: Transforming Relational ProcessesRobert M. Arnold, MDRobert M. Arnold, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-130-1-199901050-00039 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Suchman AL, Botelho RJ, Hinton-Walker P; eds. 343 pages. Rochester, NY: Univ of Rochester Pr; 1998. $95.00. ISBN 1878822802. Order phone 716-275-0419.Field of medicine: Quality improvement, delivery of health care, and patient–physician relationships.Format: Hardcover book.Audience: Health care providers, including physicians, nurses, and social workers; health care administrators; and health care educators.Purpose: To improve the quality of partnership processes within the health care system.Content: This book is divided into five sections. The first section contains conceptual material that is generic to partnerships at all levels. Each of the four subsequent sections deals with partnerships at various ... Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 5 January 1999Volume 130, Issue 1Page: 87-88KeywordsComputer softwareHealth careHealth care providersPrevention, policy, and public healthQuality improvement ePublished: 15 August 2000 Issue Published: 5 January 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Brain evolution: How constrained is it?
Authors: Georg F. Striedter
Journal: Behavioral and Brain Sciences (2001)

Allometric analyses suggest that there are some developmental constraints on brain evolution. However, when one compares animals of similar body size, these constraints do not appear to be very tight. Moreover, the constraints often differ between taxonomic groups. Therefore, one may ask not only what causes developmental constraints but also how (and why) these constraints might be altered (or circumvented) during the course of evolution.
Death, come closer
Authors: R. Smith
Journal: BMJ (2003)

Facilitating consent for trials in dying patientsResearch in palliative care settings needs novel approaches.As obtaining fully informed consent is usually impossible, research on drugs that could benefit dying patients is particularly difficult.Rees and Hardy (p 198) have developed a novel advance consent process to support a trial comparing two of the drugs commonly used for the control of "death rattle."If generally accepted, this may facilitate the research necessary to advance the care of dying patients.
Cardiovascular Abnormalities Following Surgery for Left-to-Right Shunts
Authors: RICHARD D. LUEKER, JOHN H. K. VOGEL, S. GILBERT BLOUNT
Journal: Circulation (1969)

Seventy-two patients with left-to-right shunts were studied an average of 5 years after operation. Persistent residual shunts occurred in 24 of the 72 patients and were unsuspected clinically in 11. While significant residual shunts were usually suspected in the group with ventricular septal defects (VSD), residual shunts in the group with atrial septal defects (ASD) were frequently unsuspected. Abnormalities in pulmonary vascular reactivity as determined by excessive responses to hypoxia or exercise, or both, were noted in a significant number of cases of VSD and patent ductus arteriosus. Such unusual reactivity was not seen as frequently in the ASD group. Low cardiac output responses to exercise were noted in nearly half of the patients. These studies illustrate the importance of long-term follow-up hemodynamic studies on postoperative patients with left-to-right shunts and indicate the necessity for exercise and hypoxia studies in addition to resting observations.
Abstract A95: Therapeutic effects of standardized <i>Wedelia chinensis</i> extract on prostate cancer in vivo
Authors: Pei-Wen Hsiao Hsiao, Chin-Hsien Tsai, Yu-Chih Hsiao Yang, Ming-Ting Lee
Journal: Cancer Research (2013)

Abstract Globally, prostate cancer is the sixth leading cause of cancer-related death in men with higher prevalence in Western countries. Signaling pathway of androgen receptor plays a central role in the prostate cancer progression. Accordingly, approaches and molecular mechanisms to ablate the androgen receptor function in prostate cancer have been actively studied to improve the disease treatment. However, the disease inevitably develops resistance to all forms of hormonal therapies. To mimic the clinical progression of human prostate cancer in mouse model, we implant human prostate cancer cell lines that were tagged with Luc2 reporter by lentivirus-mediated infection in the prostate gland of nude mouse. After tumor established, the orthotopic xenograft were treated with castration and progressed to castration-resistant prostate cancer (CRPC). While chemotherapy of the CRPC with intravenous docetaxel induced initial tumor regression, the tumors inevitably recurred with subsequent metastasis. We prepared a standardized herbal medicine from Wedelia chinensis plant with compounds that attenuate prostate cancer growth in vivo. Here, we investigated the combinational effect of the herbal remedy and docetaxel in the treatment of CRPC. In contrast to the docetaxel monotherapy, the docetaxel plus herbal remedy significantly delayed the tumor recurrence at primary site and distant sites, among which the CRPC in 27% mice was cured. The promising therapeutic effects of candidate herbal medicine against locally advanced tumor and subsequent metastases warrant further analyses for the underlying cellular and molecular mechanisms. (Supported by Academia Sinica, Career Development Award) Citation Format: Pei-Wen Hsiao Hsiao, Chin-Hsien Tsai, Yu-Chih Hsiao Yang, Ming-Ting Lee. Therapeutic effects of standardized Wedelia chinensis extract on prostate cancer in vivo. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Invasion and Metastasis; Jan 20-23, 2013; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2013;73(3 Suppl):Abstract nr A95.
Abstract or not abstract? Well, it depends …
Authors: Alison Pease, Alan Smaill, Markus Guhe
Journal: Behavioral and Brain Sciences (2009)

Abstract The target article by Cohen Kadosh &amp; Walsh (CK&amp;W) raises questions as to the precise nature of the notion of abstractness that is intended. We note that there are various uses of the term, and also more generally in mathematics, and suggest that abstractness is not an all-or-nothing property as the authors suggest. An alternative possibility raised by the analysis of numerical representation into automatic and intentional codes is suggested.
Coffee consumption and pancreatic cancer: temporal and spatial correlation.
Authors: M A Benarde, W Weiss
Journal: BMJ (1982)

An examination of available data on per caput consumption of coffee and pancreatic cancer mortality in the United States since 1950 shows a temporal association. A rise and fall in coffee consumption was followed by a rise and fall in the incidence of pancreatic cancer with roughly a 10-year lag. Nevertheless, there were inconsistencies in this relationship was also found between the consumption of coffee and pancreatic cancer mortality in 13 countries. While this relationship suggests an association, major inconsistencies case doubt on the possibility that it is one of cause and effect. This may be due to confounding, particularly by cigarette smoking and cancer of the pancreas is much more consistent with a causal relationship.
A Stable System for the High-Titer Production of Multiply Attenuated Lentiviral Vectors
Authors: Natacha Klages, Romain Zufferey, Didier Trono
Journal: Molecular Therapy (2000)

Lentiviral vectors open exciting perspectives for the genetic treatment of a wide array of inherited and acquired diseases, owing to their ability to govern the efficient delivery, integration, and long-term expression of transgenes into nondividing cells both in vitro and in vivo. The genomic complexity of HIV, where a whole set of genes encode virulence factors essential for pathogenesis but not required for gene transfer, allowed a major step toward clinical acceptability through the creation of multiply attenuated packaging systems. Until now, however, vector particles could only be produced by transient transfection because no high-output, stable packaging cell line was available that produced the latest generation of HIV-based vectors. Here we describe such a line, based on the doxycycline-repressible expression of HIV-1 Rev/Gag/Pol and of the vesicular stomatitis virus G envelope (VSV G) in 293 human embryonic kidney cells. Upon induction, the LVG clones can produce 1 to 20 HeLa-transducing units per cell per day for about a week, a yield that compares favorably with that of transiently transfected 293T cells. These virions exhibit functional properties similar to those of viruses produced transiently, in particular the ability to transduce nonmitotic targets. This system will facilitate the further development of lentiviral vectors for gene therapy.
Eikenella Corrodens Vertebral Osteomyelitis
Authors: LOUISE EMMETT, KEVIN C. ALLMAN
Journal: Clinical Nuclear Medicine (2000)

A 53-year-old man returned from a trip to Thailand and reported a 3-week history of severe nocturnal back pain and low-grade fevers. A magnetic resonance imaging (MRI) study performed within 1 week of the onset of symptoms showed a contrast-enhancing lesion consistent with hemangioma in the T11 vertebral body. A three-phase radionuclide bone study obtained 4 weeks later revealed intense vascularity and delayed uptake in T10 and T11, consistent with osteomyelitis. A computed tomographic (CT) scan subsequently showed bony destruction of T11 with a paraspinal soft tissue mass. Cultures of the paraspinal fluid grew Eikenella corrodens and a secondary growth of coagulase-negative Staphylococcus. E. corrodens is a small, fastidious, gram-negative anaerobic bacillus that is a normal oropharyngeal resident. The most common presentations of infection are hand abscesses after fist fights and osteomyelitis of the mandible, related to poor dental hygiene. Osteomyelitis elsewhere is rare, and the time to make a correct diagnosis is frequently prolonged. It has been reported previously in the spine of an otherwise healthy middle-aged man. The authors hypothesize that infection in the current patient may have been precipitated by transient bacteremia, with seeding of the vertebral hemangioma and subsequent infection of surrounding bone.
Heavy smoking may cause irreversible damage to arteries
Authors: J. Wise
Journal: BMJ (1998)

<h3>Introduction</h3> Worldwide, indigenous communities including American Indian(AI) youth in the United States experience poor sexual health outcomes. Inconsistent condom use among AI youth is a primary factor driving these inequalities. The Protection Motivation Theory (PMT) is valuable in explaining condom use intention (CUI) among youth and can inform the development of interventions to improve CUI and actual condom use. This analysis identifies factors of the PMT across sex and sexual experience, for predicting CUI among AI youth. <h3>Methods</h3> 267 AIs ages 13–19 from one reservation community completed a self-report measuring sociodemographic variables, psychosocial intentions and behaviours and PMT constructs (self-efficacy, response efficacy, response cost, intrinsic reward, extrinsic reward, severity, and vulnerability). Analyses were conducted using generalised estimating equation regression models, Poisson for dichotomous. <h3>Results</h3> Mean age was 15.1 years, 56% were girls and 22% sexually experienced. Among inexperienced youth, belief condoms prevent HIV, perceived severity of HIV and extrinsic rewards of sex were significantly associated with CUI. Among girls and boys, belief condoms prevent HIV, vulnerability to HIV and extrinsic rewards were significantly associated with CUI. Perceived severity was associated with CUI among boys and intrinsic rewards among girls. <h3>Conclusion</h3> This is the first study to examine PMT constructs by sex and sexual experience among AI youth. Among all but sexually active youth, PMT factors were associated with CUI indicating utility for the PMT in predicting CUI among AI youth. Results indicate HIV prevention programs may be more impactful if tailored by sex and sexual experience; among AI boys and inexperienced youth, knowledge about consequences of unsafe sex may be beneficial while addressing factors associated with internal satisfaction from sexual risk behaviours may be efficacious for girls. Programs addressing factors associated with CUI by sex and sexual experience may be more efficacious in reducing risk behaviours among AI youth.