tbuckley/cabot-search huggingface dataset:
Doctor who spiked girlfriend's drink to induce abortion is struck off
Authors: C. Dyer
Journal: BMJ (2011)

A former consultant chest physician has been struck off the medical register for trying to poison his lover to induce an abortion, and four of his research publications have been retracted after an investigation for scientific misconduct concluded that he manipulated data.

Edward Erin, a consultant at St Mary’s Hospital in London, was struck off by the General Medical Council for conduct deemed “utterly unacceptable and fundamentally incompatible with his remaining a medical practitioner.” He was sentenced to six years in prison in 2009 for attempting to procure a miscarriage by spiking the drinks of Bella Prowse, his secretary at …
Osseous Gaucher's Disease in Early Childhood
Authors: William E. Harrison, Herbert J. Louis
Journal: JAMA (1964)

A seldom considered cause of pathological fractures in children is Gaucher's disease. In our investigation of a patient with this disease, it was found that the occurrence of extensive bone erosion without splenomegaly has not been previously reported in the very young. Although there is no specific test for the abnormal cerebroside, thorough histological studies corroborated the diagnosis. The elevation of acid phosphatase demonstrated in this case is particularly significant since it is almost invariably associated with this disease and represents a simple confirmatory test. The course of this patient has been unpredictable as might be expected since there is little correlation between the clinical manifestations and the degree of histological infiltration by the abnormal cells.
Abstract 3063: Mcl-1 dependency is a predictive biomarker for apoptotic induction by short-term dinaciclib (SCH 727965) treatment
Authors: Robert Booher, Heather Hirsch, Peter Strack, Leigh Zawel, Stephen Fawell
Journal: Cancer Research (2012)

Abstract Dinaciclib (SCH 727965) is a potent and selective inhibitor of the cyclin-dependent kinases (CDKs) 1, 2, 5 and 9 undergoing clinical testing against a range of solid and hematologic malignancies. From preclinical studies, more than 140 cell lines have been profiled for dinaciclib response in long-term (&amp;gt;72 hrs) viability or clonogenicity assays with &amp;gt;97% of the lines showing IC50 β25 nM. This uniformly low nM potency is likely due to repression of both cell cycle progression and transcription through inhibition of CDK1/2 and CDK9, respectively. CDK9 phosphorylation of the RNA pol II (RNAPII) at Ser2 and 5 is required for transcriptional initiation and elongation. We and others have observed rapid CDK9-dependent effects on cells after short-term dinaciclib exposure, including loss of RNAPII Ser2 phosphorylation followed by rapid elimination of the short half-life, pro-survival protein Mcl-1. Since a cancer cell's ability to avoid apoptosis is dependent on the balance of several Bcl-2 antiapoptotic family members, including Bcl-2, Bcl-xL and Mcl-1, we hypothesized that Mcl-1 dependent cell lines would be more sensitive to dinaciclib treatment. Moreover, we anticipated that this differential sensitivity could be discriminated from longer-term inhibitory cell cycle effects by conducting short-term dinaciclib exposure assays. Here we report the activity of dinaciclib to induce apoptosis on a panel of 25 human solid tumor cell lines with varying levels of Mcl-1 dependency. Mcl-1 dependency in solid tumor cell lines has been reported to correlate with the Mcl-1 to Bcl-xL mRNA ratio or the level of Mcl-1 gene amplification. Cell viability was assessed after an 18 hour, 100 nM dinaciclib treatment while target engagement and induction of apoptosis was determined after 8 hours. With one exception, all cell lines showed potent CDK9 target engagement as determined by loss of RNAPII Ser2 phosphorylation and corresponding reduced Mcl-1 protein levels. We observed that loss of cell viability, measured by ATP content, directly correlated with the Mcl-1/Bcl-xL mRNA ratio. A dramatic increase in PARP cleavage was also observed in cell lines with the highest Mcl-1/Bcl-xL mRNA ratio. Furthermore, the extent of PARP cleavage correlated with levels of caspase-3/7 activity. Bcl-2 levels did not significantly impact the dinaciclib response. These data provide a rationale for utilizing Mcl-1 dependency as a predictive biomarker for dinaciclib anti-cancer response in solid tumor malignancies. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3063. doi:1538-7445.AM2012-3063
Sorbinil and Limited Joint Mobility in Diabetics-Reply
Authors: R. Phillip Eaton
Journal: JAMA (1985)

In Reply.—  The concerns of Dr Frank that the enzyme aldose reductase may be intracellular and thus unavailable to produce sugar alcohols for collagen incorporation are appropriate. Since the 1959 investigation of Van Heyningen et al 1 with dialyzed extracts of rat lens, all studies of this enzyme have used total tissue extracts with no attempt to distinguish between intracellular and extracellular enzyme. Thus, the actual tissue location of aldose reductase is not established.  In fact, the actual issue is not the location of the enzyme aldose reductase, but in what site the polyol accumulates, independent of its site of generation. Microscopic examination of nerves from galactose-fed rats and streptozotocin-treated diabetic rats has demonstrated accumulation of water in the endoneurial space surrounding the axon, while the axon actually appears to shrink in diameter. 2,3 It has even been suggested that chronic hyperosmolality of endoneurium interstitial fluid could produce axon shrinkage
A Radioimmunoassay Using a Monoclonal Antibody to Monitor the Course of Epithelial Ovarian Cancer
Authors: R C Bast, T L Klug, E St John, E Jenison, J M Niloff, H Lazarus, R S Berkowitz, T Leavitt, C T Griffiths, L Parker, V R Zurawski, R C Knapp
Journal: New England Journal of Medicine (1983)

The murine monoclonal antibody OC 125 reacts with an antigen (CA 125) common to most nonmucinous epithelial ovarian carcinomas. An assay has been developed to detect CA 125 in serum. By this assay, only 1 per cent of 888 apparently healthy persons and 6 per cent of 143 patients with nonmalignant disease had serum CA 125 levels above 35 U per milliliter. In contrast, 83 of 101 patients (82 per cent) with surgically demonstrated ovarian carcinoma had elevated levels of antigen. In 38 patients with epithelial ovarian carcinoma monitored on 2 to 18 occasions during 2 to 60 months, antigen levels ranged from less than 1 to more than 8000 U per milliliter. Rising or falling levels of CA 125 correlated with progression or regression of disease in 42 of 45 instances (93 per cent). Determination of CA 125 levels may aid in monitoring the response to treatment in patients with epithelial ovarian cancer. (N Engl J Med 1983; 309:883–7.)
The Chinese Art of Healing
Authors: Ilza Veith
Journal: JAMA (1972)

This remarkably timely book was not written to exploit the current vogue of interest in Chinese medicine, but it is a new English translation of the original German and Hungarian editions which were simultaneously published in 1963. The book reflects the unusual background of its Hungarian-born author who had elected to lead the life of a Buddhist monk in a Tibetan monastery and even joined it in its eventual exile in Switzerland. The author's long and thorough exposure to Far Eastern life and medical practices has endowed the book with considerable depth and authenticity. The work deals clearly and succinctly with the archaic theories underlying the traditional Chinese medical practices, some of which are now so prominently featured by the recent visitors to China and the Western news media. In this connection it is important to note that even as recently as 1963, acupuncture, although widely used as analgesic for
IMMUNOCHEMICAL STUDIES ON THE GROUP AND TYPE ANTIGENS OF GROUP F STREPTOCOCCI AND THE IDENTIFICATION OF A GROUPLIKE CARBOHYDRATE IN A TYPE II STRAIN WITH AN UNDESIGNATED GROUP ANTIGEN
Authors: Marc F. Michel, Richard M. Krause
Journal: The Journal of Experimental Medicine (1967)

Two antigens, the group-specific carbohydrate and the Type II carbohydrate, have been isolated by cellulose column chromatography from a formamide extract of a Group F streptococcus. Chemical and immunologic analyses indicate that both antigens are free of other cellular components. Both antigens are components of the cell wall although the Type II antigen is probably more superficial than the group antigen. The Type II antigen is composed of rhamnose, glucose, galactose, and galactosamine. The Group F antigen is composed of rhamnose, glucose, galactosamine and a small percentage of glucosamine. A grouplike carbohydrate and the Type II carbohydrate have been isolated from a streptotoccal strain which lacks a serologically detectable streptococcal group antigen. This grouplike carbohydrate, which does not cross-react immunologically with Group F serum, is composed of rhamnose, galactose, and glucosamine. No chemical or immunological differences were observed between the Type II antigen isolated from the Group F strain and the Type II antigen isolated from the nongroupable strain.
Managing Medical Resources
Authors: Christine K. Cassel, Troyen E. Brennan
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TEMPORAL TRENDS AND MICROBIOLOGICAL PREDICTORS OF VALVE REPLACEMENT FOR IE FROM 2000-2011, A NATIONWIDE PERSPECTIVE
Authors: Sadip Pant, Abhishek Deshmukh, Nileshkumar Patel, Kathan Mehta, Neeraj Shah, Ankit Chothani, Smith Giri, Apurva Badheka, Jawahar Mehta
Journal: Journal of the American College of Cardiology (2014)
Lack of Effects of Hypoglycemia on Glucose Absorption in Healthy Men
Authors: Jens Møller, Michael F Laker, Susan M Gillespie, Per G Ovesen, Niels Abildgaard, Rong Tian, Jens O Jørgensen, Niels Møller
Journal: Diabetes Care (1992)

OBJECTIVE To assess the effects of hypoglycemia on glucose absorption by examining the systemic appearance of 3-OMG (a glucose analogue that is transported by the same mechanism as glucose) after oral administration. RESEARCH DESIGN AND METHODS Six healthy males 22–31 yr of age were studied during a hypoglycemic (50 mg [2.7 mM]/100 ml) and a euglycemic (90 mg [5.0 mM]/100 ml) glucose clamp. At 50 min after exposure to insulin, an oral glucose load containing 20 g of glucose and 4.5 g of 3-OMG dissolved in 300 ml of tap water was administered. Insulin administration was interrupted 30 min after oral glucose administration. RESULTS Plasma glucose was clamped at 88 ± 1.3 mg (4.9 ± 0.1 mM)/100 ml during euglycemia and at 50 ± 1.9 mg (2.7 ± 0.1 mM)/100 ml during hypoglycemia. Concentrations of glucagon, growth hormone, cortisol, and epinephrine were significantly elevated during hypoglycemia. After 60 min, circulating 3-OMG concentrations increased to zeniths of 11.4 ± 0.2 mg (585 ± 10.0 mM)/100 ml (hypoglycemia) and 11.6 ± 1.1 mg (585 ± 56.0 μM)/100 ml (euglycemia; P = 0.95). Absorption of 3-OMG was evident between 15 and 20 min after administrations in both situations. Serum insulin was significantly lower during hypoglycemia compared with the control situation (345 ± 50 microM [hypoglycemia], 445 ± 50 μM [euglycemia], P = 0.03). CONCLUSIONS We conclude that hypoglycemia does not seem to affect intestinal absorption of glucose as judged by systemic appearance of 3-OMG.
Reduced lipid peroxidation in dilated hearts of cardiomyopathy turkeys
Authors: D. LAX, S.-L. ZHANG, Y. LI, L. WILLIAMS, J. M BERRY, J. ELSPERGER, N. A STALEY, G. R NOREN, S. EINZIG
Journal: Cardiovascular Research (1988)

Journal Article Reduced lipid peroxidation in dilated hearts of cardiomyopathy turkeys Get access DANIELA LAX, DANIELA LAX **From the Department of Pediatrics, University of Minnesota, Veterans Administration Medical Center, Minneapolis, Minnesota, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar SHU-LUN ZHANG, SHU-LUN ZHANG **From the Department of Pediatrics, University of Minnesota, Veterans Administration Medical Center, Minneapolis, Minnesota, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar YING LI, YING LI **From the Department of Pediatrics, University of Minnesota, Veterans Administration Medical Center, Minneapolis, Minnesota, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar LEE WILLIAMS, LEE WILLIAMS **From the Department of Pediatrics, University of Minnesota, Veterans Administration Medical Center, Minneapolis, Minnesota, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar JAMES M BERRY, JAMES M BERRY **From the Department of Pediatrics, University of Minnesota, Veterans Administration Medical Center, Minneapolis, Minnesota, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar JOSEPH ELSPERGER, JOSEPH ELSPERGER †From the Department of the Hennepin County Medical Center, Veterans Administration Medical Center, Minneapolis, Minnesota, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar NANCY A STALEY, NANCY A STALEY †From the Department of the Hennepin County Medical Center, Veterans Administration Medical Center, Minneapolis, Minnesota, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar GEORGE R NOREN, GEORGE R NOREN †From the Department of the Hennepin County Medical Center, Veterans Administration Medical Center, Minneapolis, Minnesota, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar STANLEY EINZIG STANLEY EINZIG **From the Department of Pediatrics, University of Minnesota, Veterans Administration Medical Center, Minneapolis, Minnesota, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 22, Issue 11, November 1988, Pages 826–832, https://doi.org/10.1093/cvr/22.11.826 Published: 01 November 1988 Article history Received: 08 January 1988 Accepted: 25 May 1988 Published: 01 November 1988
Health in South Asia: Research cannot be funded when health itself has low priority
Authors: Ali Asgar A Behranwala
Journal: BMJ (2004)

Future of Kerala depends on its willingness to learn from pastEditor-The Kerala model in health, cited by Bhutta et al in the theme issue on health in South Asia as replicable for South Asian countries, 1 is facing serious threats.The state has a triple burden of communicable, non-communicable, and traumatic diseases.Stupendous growth of the private sector has resulted in skyrocketing healthcare costs.Lured by the hi tech sophistication of the private sector, people are abandoning basic principles of primary health care.Even poor people prefer private hospitals, and a major reason for sustaining poverty is healthcare cost. 2 The government is reducing its investments in health and education due to fiscal crises and pressure from funding and lending agencies.The opening up of the medical education sector to private entrepreneurs, lack of guidelines for the private practice of government doctors, and shortage of doctors for rural areas are all disturbing developments.Transfer of healthcare institutions under local self-governments is yet to show the desired benefits.The state is developing a long term plan, "Health Vision Kerala 2025," and a health policy.To equip the primary healthcare workforce to face the emerging challenges, 3 job responsibilities were redefined recently.Factors that determined the successful Kerala model, among others, include historically prevalent social justice, commitment of governments to health and education, land reforms, an organised public distribution system, streamlined primary health care, and an organised labour sector.Deterioration in these determinants is likely to have strong negative impact.Kerala should learn from its past to avoid the sad plight of some other Indian states.
Dystonic Symptoms in Children
Authors: Martin Geller
Journal: JAMA (1974)

Eight patients with dystonia, four with hereditary torsion dystonia and four with acquired dystonia, were treated with carbamazepine in doses ranging from 300 to 1,200 mg/day. Drowsiness was the only side effect and periodic blood cell counts remained normal. All have shown sustained improvement of some manifestations of their illness for periods up to one year. (<i>JAMA</i>229:1755-1757, 1974)
Dose of Prophylactic Platelet Transfusions and Prevention of Hemorrhage
Authors: Sherrill J. Slichter, Richard M. Kaufman, Susan F. Assmann, Jeffrey McCullough, Darrell J. Triulzi, Ronald G. Strauss, Terry B. Gernsheimer, Paul M. Ness, Mark E. Brecher, Cassandra D. Josephson, Barbara A. Konkle, Robert D. Woodson, Thomas L. Ortel, Christopher D. Hillyer, Donna L. Skerrett, Keith R. McCrae, Steven R. Sloan, Lynne Uhl, James N. George, Victor M. Aquino, Catherine S. Manno, Janice G. McFarland, John R. Hess, Cindy Leissinger, Suzanne Granger
Journal: New England Journal of Medicine (2010)

We conducted a trial of prophylactic platelet transfusions to evaluate the effect of platelet dose on bleeding in patients with hypoproliferative thrombocytopenia.
Seronegative Lyme Disease and Transitory Atrioventricular Block
Authors: Franjo Pikelj
Journal: Annals of Internal Medicine (1989)

Letters and Corrections1 July 1989Seronegative Lyme Disease and Transitory Atrioventricular BlockFranjo Pikelj, MD, Franc Strle, MD, Martin Mozina, MDFranjo Pikelj, MDSearch for more papers by this author, Franc Strle, MDSearch for more papers by this author, Martin Mozina, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-111-1-90_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:McAllster and coworkers (1) recently reported the cases of four patients with Lyme disease associated with complete heart block. We wish to describe another case. A 28-year-old nun who had previously been healthy was admitted to the hospital on 21 September 1988 after 1 week of exertional dyspnea, rhythm disturbances, and several syncopal episodes with no associated convulsions. She had been bitten by a tick above the left knee at the end of July 1988. Three days later, she had noticed an erythematous rash surrounding the bite, which had increased in size and cleared in the center....References1. McAlisterKlementowiczAndrewsFisherFeldFurman HPCJMS. Lyme carditis: an important cause of reversible heart block. Ann Intern Med. 1989;110:339-45. LinkGoogle Scholar2. StrlePejovnik-PustinekStanekPleterski FAGD. Lyme borreliosis in Slovenia. Zbl Bakt Hyg A. 1989; in press. Google Scholar3. StiernstedtGustafssonKarlssonSvenungssonSköldenberg GRMBB. Clinical manifestations and diagnosis of neuroborreliosis. Ann NY Acad Sci. 1988;539:46-55. CrossrefMedlineGoogle Scholar4. DattwylerVolkmanLuftHalperinThomasGolightly RDBJJM. Seronegative Lyme disease. N Engl J Med. 1988; 319:1441-6. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University Clinical Center Ljubljana Ljubljana Yugoslavia PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPhysical Therapist Recognition and Referral of Individuals With Suspected Lyme DiseaseManagement of suspected Lyme borreliosis: experience from an outpatient parenteral antibiotic therapy serviceLyme borreliosis 1 July 1989Volume 111, Issue 1Page: 90-90KeywordsCardiovascular therapyConvulsionsDyspneaKneesLyme diseaseRashesSyncopeTicks Issue Published: 1 July 1989 PDF downloadLoading ...
Review: Home and clinic BP have limited accuracy compared with ambulatory BP for diagnosing hypertension
Authors: Ross D. Feldman
Journal: Annals of Internal Medicine (2011)

Source Citation Hodgkinson J, Mant J, Martin U, et al. Relative effectiveness of clinic and home blood pressure monitoring compared with ambulatory blood pressure monitoring in diagnosis of hypertension: systematic review. BMJ. 2011;342:d3621. 21705406
The Role of Glycogen Synthase Kinase 3β in the Transformation of Epidermal Cells
Authors: Cuiling Ma, Jian Wang, Ying Gao, Tian-Wen Gao, Gang Chen, Kimberly A. Bower, Mohammed Odetallah, Min Ding, Zunji Ke, Jia Luo
Journal: Cancer Research (2007)

Abstract Glycogen synthase kinase 3β (GSK3β) is a multifunctional serine/threonine kinase. We showed that the expression of GSK3β was drastically down-regulated in human cutaneous squamous cell carcinomas and basal cell carcinomas. Due to its negative regulation of many oncogenic proteins, we hypothesized that GSK3β may function as a tumor suppressor during the neoplastic transformation of epidermal cells. We tested this hypothesis using an in vitro model system, JB6 mouse epidermal cells. In response to epidermal growth factor (EGF) or 12-O-tetradecanoylphorbol-13-acetate (TPA), the promotion-sensitive JB6 P+ cells initiate neoplastic transformation, whereas the promotion-resistant JB6 P− cells do not. JB6 P− cells expressed much higher levels of GSK3β than JB6 P+ cells; JB7 cells, the transformed derivatives of JB6, had the least amount of GSK3β. The activity of GSK3β is negatively regulated by its phosphorylation at Ser9. EGF and TPA induced strong Ser9 phoshorylation in JB6 P+ cells, but phosphorylation was seen at a much lesser extent in JB6 P− cells. EGF and TPA-stimulated Ser9 phosphorylation was mediated by phosphoinositide-3-kinase (PI3K)/Akt and protein kinase C (PKC) pathways. Inhibition of GSK3β activation significantly stimulated activator protein-1 (AP-1) activity. Overexpression of wild-type (WT) and S9A mutant GSK3β in JB6 P+ cells suppressed EGF and TPA-mediated anchorage-independent growth in soft agar and tumorigenicity in nude mice. Overexpression of a kinase-deficient (K85R) GSK3β, in contrast, potentiated anchorage-independent growth and drastically enhanced in vivo tumorigenicity. Together, these results indicate that GSK3β plays an important role in skin tumorigenesis. [Cancer Res 2007;67(16):7756–64]
An unusual but easily treatable cause of dysphagia and dysarthria complicating stroke.
Authors: A J Wright
Journal: BMJ (1985)

A propos de 3 observations. Apres un ictus, surtout si le malade a ete traite par myoresolutifs, la dysarthrie et la dysphagie peuvent etre dues a des luxations de l'articulation temporo-maxillaire. Des controles radiographiques sont conseilles