tbuckley/cabot-search huggingface dataset:
Points from Letters: Added Years
Authors: J. H. Pratt-Johnson
Journal: BMJ (1974)

average superannuable income of the 80 main Swansea principles for the year ended March 1974, a figure which included seniority payments.Published surveys have suggested that the local work load is up to twice the national average.Since April 1974 reorganization has brought all sectors of the profession into management participation with an ever- increasing number of managers in the Health Service whose duties and salaries are pub- lished.The nearest managers to the general practitioner are those at district level and the regional medical officers.For a five-day week they average a superannuable income of £7,500.General practitioners, with other clinicians, provide more than a five-day service but are unique in having to provide their own locums for sickness, study, and annual leave from income; and since reorganization parti- cipation in management through a host of new advisory committees, completely unpaid, make further inroads into the unsocial (leisure) periods.Kindersley recognized a shortfall in remuneration from 1966 which is still uncorrected and increasing.Achieve- ments with dynamism, buying added years, and threshold awards are only tinkering with the problem when the basic contract is faulty.We owe a duty to our dependants and successors to correct the discrepancy or our principal concern, the patient, will find the standard of his primary care in jeopardy.-I am, etc.,
Abstract 3548: Role of synuclein-gamma (SNCG) in paclitaxel resistance and mitogen activated protein kinase activation in uterine papillary serous carcinoma(UPSC)
Authors: Eloise Chapman-Davis, Parin A. Patel, J. Julie Kim, Barbara Buttin
Journal: Cancer Research (2010)

Abstract Objectives: SNCG is a novel prognostic biomarker in UPSC. We have shown that its overexpression correlates with aggressive cellular properties and resistance to paclitaxel in a UPSC cell line (SPEC2) as well as poor prognosis in a pilot set of UPSC patients. The goal of this study was to determine the mechanism of SNCG-associated taxane resistance by evaluating the effect of SNCG on the mitotic checkpoint and its propensity to modulate extracellular signal-regulated protein kinase 1/2 (ERK 1/2) signaling pathways. Methods: A stably transfected SPEC2 cell line was created using shSNCG versus shControl oligonucleotides. Similarly, Ishikawa cells were transiently transfected with an SNCG expression vector versus empty vector. Differences in cell proliferation were measured using a cell viability assay and BrdU incorporation assay after treatment with paclitaxel. Cell cycle analysis was used to study the effect of SNCG on the mitotic checkpoint. Differences in expression of the checkpoint kinase BubR1 due to SNCG were studied using real time PCR, Western blot, 26S ubiquitin-proteasome inhibition, and siRNA to BubR1. ERK and phospho-ERK levels were measured in SPEC2 cells with and without SNCG expression by Western blot. SPEC2 cells were treated with paclitaxel with and without the MEK inhibitor UO126 and apoptosis was measured using cleaved PARP analysis. Results: SNCG overexpression lead to acquired, reversible paclitaxel resistance in endometrial cancer cell lines. SNCG was noted to interfere with mitotic checkpoint function by causing degradation of the critical checkpoint protein BubR1 thereby allowing cells to escape paclitaxel-induced mitotic arrest. SPEC2 cells exhibited sustained activation of ERK which was attenuated by silencing SNCG. When SPEC2 cells were exposed to paclitaxel combined with the MEK inhibitor UO126, decreased cell viability and increased apoptosis was noted compared to either agent alone. SNCG knockdown further enhanced paclitaxel and UO126 sensitivity. Cell cycle analysis revealed that silencing SNCG in SPEC2 cells and adding UO126 acted synergistically in overcoming paclitaxel resistance. Conclusions: SNCG overexpression in UPSC leads to taxane resistance by interacting with the mitotic checkpoint kinase BubR1 causing its degradation. SNCG is also associated with sustained ERK activation. Targeting SNCG in conjunction with MEK inhibition may represent a novel therapeutic strategy to overcome taxane resistance in these cells. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3548.
Stability of Adenoviral Vectors Following Catheter Delivery
Authors: Lisa V. Tsui, Nathalie Zayek, David Frey, Christopher Mello, Gautam Banik, Robert Falotico, James G. McArthur
Journal: Molecular Therapy (2001)

Adenoviral vectors have shown promise in a variety of preclinical vascular disease models. Intravascular infusion is one methodology to introduce the adenoviral vector into the affected area of the blood vessel. The biocompatibility of the infusion catheter with the adenoviral vector is key for successful local transfer. It has been recently suggested that catheter-based delivery of adenoviral vectors may result in the loss of vector infectivity. We demonstrate here a catheter capable of delivering adenoviral vectors without the loss of viral particle or infectious titers. First- (DeltaE1) and second- (DeltaE1/DeltaE4) generation adenoviral vectors were tested for their biocompatibility with the Crescendo microporous infusion catheter, which is designed for local infusion of therapeutic agents to human coronary or peripheral arteries. We found that incubation of either the DeltaE1 or the DeltaE1/DeltaE4 viral vectors for up to 30 min in the catheter at 37 degrees C did not result in a loss of viral particles or of viral infectivity. Here, we show that the Crescendo catheter is biocompatible with adenoviral vectors and suitable for vascular gene therapy.
Lesions due to Vesicants: Diagnosis and Treatment
Authors: W. E. Chiesman
Journal: BMJ (1944)

MEDICAL JOURNAL109tance to retain, so far as was possible, all cases in the command on at least some form of duty, and to confine evacuation out of the command to psychotic cases and those neurosis cases in which, for various reasons, the ultimate prognosis was regarded as very unfavourable.As a result of practical experi- ence this policy was further developed, and it was decided that psychotic cases, after recovery and if considered suitable on other grounds, should also be retained in the command.This rather radical revision of policy in the case of psychotics was adopted only after careful consideration, but has already proved successful in practice.The following statistics are of interest in assessing the prognosis and the results of treatment.ln a series of 350
Improvement of Diabetic Retinopathy after Hypophyseal-Stalk Section in a Patient Whose Adrenal Glands Had Been Removed
Authors: Herbert Lourie, Arnold Moses, Charles Lloyd
Journal: New England Journal of Medicine (1962)

THE metabolic derangements of diabetes mellitus have been controlled by insulin therapy, but the degenerative changes in this disease continue to take their toll. The changes in the renal and retinal capillaries and the sequelae of these lesions are characteristic of diabetes mellitus. Controversy exists about the causative factors in these degenerative changes.1 The anterior pituitary gland and adrenal cortex have been implicated because of the following observations: the reported worsening of diabetic retinopathy during periods of stress2 , 3; the development of capillary aneurysms in nondiabetic patients during periods of treatment with ACTH and the disappearance of lesions after cessation . . .
Iodine Supplements During and After Pregnancy
Authors: Marisa Rebagliato, Jesus Vioque, Juan José Arrizabalaga
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Public health consequences of global climate change in the United States--some regions may suffer disproportionately.
Authors: J Longstreth
Journal: Environmental Health Perspectives (1999)

Current risk assessments of the likely regional health impacts of global climate change (GCC) are hindered by two factors. First, dose-response relationships between weather parameters and many of the likely health effects have not been developed, and second, reliable estimates of future regional climates across the United States are still beyond the scope of current modeling efforts. Consequently, probabilistic risk estimates of most of the likely regional health impacts of GCC have such a high degree of uncertainty that their usefulness to health officials dealing with regional issues is very limited. With the numerous pressures on today's health care systems, it is understandable that the possible consequences of GCC have received scant attention from regional health care decision makers. Indeed, the consensus among this community appears to be that any increases in health effects associated with GCC will be easily handled by the current health care system. However, such a position may be naive as the potential exists that an unequal distribution of such effects could overwhelm some regions, whereas others may feel little or no impact. This review of the likely regional impacts of GCC has been structured as a semianalytical look at this issue of distributional effects. Because of the lack of dose-response information and reliable estimates of future regional climates, however, it takes a historical perspective. That is, it assumes that the quality and quantity of health risks a region faces under GCC will be directly related to its recent history of health risks from warm weather/climate-related diseases as well as to the size, characteristics, and distribution of the sensitive subpopulations currently residing within its borders. The approach is semiquantitative; however, it uses national data gathered on a regional level and as such should only be used to generate a hypothesis rather than test it. When applied to the United States, its outcome leads to the hypothesis that if indeed history repeats itself, some states or regions may be more greatly affected by GCC than others, not only because historically they are more prone to summer weather/climate-related diseases, but also because they contain a greater proportion of the sensitive subpopulations in the United States.
Winter virus closes Scottish hospitals
Authors: B. Christie
Journal: BMJ (2002)

A monitoring programme is to be accelerated at Scottish hospitals to check if they are meeting new national standards on infection control. It follows the deaths of three patients at Glasgow's Victoria Infirmary from salmonella poisoning and an outbreak of a gastric virus at several other hospitals.

The viral infection, which causes severe vomiting and fever, has affected many parts of Britain, but Scotland has been worst hit. Almost 300 patients and staff at the Victoria Infirmary contracted the virus, and the hospital was forced to close …
DNA Damage Signaling in Hematopoietic Cells: A Role for Mre11 Complex Repair of Topoisomerase Lesions
Authors: Monica Morales, Yan Liu, Evagelia C. Laiakis, William F. Morgan, Stephen D. Nimer, John H.J. Petrini
Journal: Cancer Research (2008)

Abstract The Mre11 complex promotes DNA double-strand break repair and regulates DNA damage signaling via activation of the ataxia-telangiectasia mutated (ATM) kinase. The hypermorphic Rad50S allele encodes a variant of Rad50, a member of the Mre11 complex. Cells expressing Rad50S experience constitutive ATM activation, which leads to precipitous apoptotic attrition in hematopoietic cells. In this study, we show that ATM activation by the Rad50S-containing Mre11 complex enhances the proliferation of LSK cells, a population consisting of hematopoietic stem cells and multipotent progenitor cells. In Rad50S/S mice, enhanced LSK proliferation triggers apoptotic attrition. This phenotype is mitigated when Rad50S/S is combined with mutations that alter either LSK cell quiescence (myeloid elf-1–like factor/ELF4–deficient mice) or hematopoietic differentiation (p21- and p27-deficient mice), indicating that the LSK population is a primary target of Rad50S pathology. We show that cells from Rad50S/S mice are hypersensitive to camptothecin, a topoisomerase I inhibitor that causes DNA damage primarily during DNA replication. On this basis, we propose that apoptotic attrition of Rad50S/S hematopoietic cells results from enhanced proliferation in the context of topoisomerase-associated DNA damage. Impairment of apoptosis in Rad50S/S mice promotes hematopoietic malignancy, suggesting that primitive hematopoietic cells serve as a reservoir of potentially oncogenic lesions in Rad50S/S mice. These data provide compelling evidence that the Mre11 complex plays a role in the metabolism of topoisomerase lesions in mammals, and further suggest that such lesions can accumulate in primitive hematopoietic cells and confer significant oncogenic potential. [Cancer Res 2008;68(7):2186–93]
Secondary Carcinoma Involving the Left Atrium
Authors: R. D. Caldroney, E. C. Elliott
Journal: CA A Cancer Journal for Clinicians (1984)

Although involvement of the heart by metastatic cancer is not uncommon, it is particularly unusual for such tumors to involve the endocardial surface and obstruct blood flow, in the patient described, a large cell, undifferentiated carcinoma of the lung migrated down the pulmonary vein into the left atrium. The clinical picture was consistent with the intermittent ball-valve effect seen with atrial myxomas. The frequency and clinical effects of secondary carcinomas involving the endocardial surface are discussed.
Lessons from health during the transition from communism
Authors: Martin McKee, Ellen Nolte
Journal: BMJ (2004)

Countries that are in transition from communism provide the opportunity for comparing the effects on health of communist and democratic political systems Summary pointsCountries in transition from communism provide valuable information on the effects of democracy on health Health improvements have been greatest in countries that have embraced democracy most enthusiastically Lack of democratic structures in some countries of the former Soviet Union acts as a barrier to the implementation of healthy public policies Content relevant to developing countries of four leading medical journals in January 2002 and January 2003.
ON THE CONSOLIDATION OF THE PUBLIC AND PROFESSIONAL INTERESTS OF MEDICAL MEN
Authors: V. Horsley
Journal: BMJ (1903)

I wish at the outset to endorse heartily what has fallen from the President to the effect that the interests of the profession are the interests of the public.Of course, this is a very difficult point for mem- bers of the lay public to grasp.They do not realize at the present time how -absolutely, whatever helps forward the medical profession, will of necessity help forward their in- terests to a much wider extent.Now, as to our interests as members of the profession.THE NEEDS OF THE PRACTITIONER.It seems to me we can judge of those interests best if we consider for a moment what are the requirements of the practitioner.Now the requirements of all of us as practitioners may be divided under two heads.First social, and secondly scientific. SOCIAL.As regards our social requirements-that is our requirements in relation to the community at large-we require freedom to practise our profession while at the same time, if possible, we should be defended from unjust attacks.Secondly, we require security for our legal rights to practise.We have legal rights under the Medical Acts, but we have very little security for those rights; and we want also support against illicit competition such as quackery, medical aid societies, and so forth.So much for our social requirements. SCIENTIFIC.In order that we may practise our profession properly we require opportunities of meeting for the discussion of medical and scientific questions, and we require, above all, in addition to those opportunities, a system for the rapid diffusion of knowledge.LOCAL MEDICAL SOCIETTES.Now, during the last 150 years to meet those requirements various societies and associations have been formed.But the formation of medical societies is a much more modern affair, think, than is generally understood.I have put together in a diagram the dates at which the learned medical societies in England were founded, and if you begin at i8oo, the date on which the Leicester Society was founded, you will find a"cording to this scale, that until i88o very few were insti- tuted, whereas in the decade from 1890 to 1900 no less than twenty-three societies were formed.MEDICAL SOCIETIES (ENGLAND).25q 15-IC-A44 M~2 El Learned.
Small-Bowel Obstruction
Authors: Fabrice Dedouit, Philippe Otal
Journal: New England Journal of Medicine (2008)

A 72-year-old woman presented with a 2-day history of abdominal pain associated with nausea and vomiting. Over the previous 10 years, she had had progressive Alzheimer's disease, requiring her to live in a long-term care facility. On physical examination, there were no abdominal scars or umbilical, inguinal, or femoral hernias. Laboratory tests revealed a normal white-cell count, and an abdominal radiologic examination was suggestive of a complete small-bowel obstruction (Panel A). Computed tomography showed small-bowel obstruction by an intraluminal mass (Panel B, arrow). This mass had a hyperdense periphery and an aerated core. During laparotomy, an enterotomy was performed and . . .
Immediate and Delayed Neurotoxicity After Mechlorethamine Preparation for Bone Marrow Transplantation
Authors: KEITH M. SULLIVAN
Journal: Annals of Internal Medicine (1982)

Twenty-four patients, including two with aplastic anemia and 22 with malignancy, underwent marrow transplantation after preparation with mechlorethamine, 0.3 to 2.0 mg/kg body weight. Fourteen of the 21 neurologically evaluable recipients developed immediate neurotoxicity a median of 4 days after treatment (range, 0 to 34 days). Confusion and disorientation were observed in six patients, headache in six, hallucinations in four, lethargy in four, tremors in three, paraplegia in one, seizure in one, and vertigo in one. Whereas acute symptoms cleared in 11 patients, three remained symptomatic until death. Twelve evaluable patients survived more than 60 days; all six with previous acute toxicity subsequently developed delayed onset of new neurologic findings (personality change, confusion, seizure, diplopia, or dementia) a median of 169 days (range, 70 to 248 days) after treatment. Cerebrospinal fluid analysis was usually normal but cerebral computed tomographic scans showed ventricular enlargement and electroencephalograms showed diffuse slowing. Postmortem histologic examination of brain showed neuronal degenerative changes with increased vascularity, gliosis, and perivascular fibrosis. Neurotoxicity appeared to increase with age and mechlorethamine dose and was commoner in patients given additional procarbazine or cyclophosphamide.
Effectiveness of vertebroplasty using individual patient data from two randomised placebo controlled trials: meta-analysis
Authors: M. P. Staples, D. F. Kallmes, B. A. Comstock, J. G. Jarvik, R. H. Osborne, P. J. Heagerty, R. Buchbinder
Journal: BMJ (2011)

To determine whether vertebroplasty is more effective than placebo for patients with pain of recent onset (≤ 6 weeks) or severe pain (score ≥ 8 on 0-10 numerical rating scale).Meta-analysis of combined individual patient level data.Two multicentred randomised controlled trials of vertebroplasty; one based in Australia, the other in the United States.209 participants (Australian trial n = 78, US trial n = 131) with at least one radiographically confirmed vertebral compression fracture. 57 (27%) participants had pain of recent onset (vertebroplasty n = 25, placebo n = 32) and 99 (47%) had severe pain at baseline (vertebroplasty n = 50, placebo n = 49).Percutaneous vertebroplasty versus a placebo procedure.Scores for pain (0-10 scale) and function (modified, 23 item Roland-Morris disability questionnaire) at one month.For participants with pain of recent onset, between group differences in mean change scores at one month for pain and disability were 0.1 (95% confidence interval -1.4 to 1.6) and 0.2 (-3.0 to 3.4), respectively. For participants with severe pain at baseline, between group differences for pain and disability scores at one month were 0.3 (-0.8 to 1.5) and 1.4 (-1.2 to 3.9), respectively. At one month those in the vertebroplasty group were more likely to be using opioids.Individual patient data meta-analysis from two blinded trials of vertebroplasty, powered for subgroup analyses, failed to show an advantage of vertebroplasty over placebo for participants with recent onset fracture or severe pain. These results do not support the hypothesis that selected subgroups would benefit from vertebroplasty.
The Effect of China's One-Child Family Policy after 25 Years
Authors: Therese Hesketh, Li Lu, Zhu Wei Xing
Journal: New England Journal of Medicine (2005)

In 1979, China implemented the one-child family policy, which restricts many couples to a single offspring. The authors describe the policy's success in slowing population growth as well as its adverse consequences, such as increasing the ratio of men to women.
Dexamethasone receptors in human epidermis
Authors: A. HUGHES, H.J. YARDLEY
Journal: British Journal of Dermatology (1982)

Journal Article Dexamethasone receptors in human epidermis Get access A. HUGHES, A. HUGHES Department of Medicine, The Medical School, Birmingham 615 2TJ Search for other works by this author on: Oxford Academic Google Scholar H.J. YARDLEY H.J. YARDLEY Department of Biological Sciences, University of Keele, Staffs Dr H.J.Yardley, Department of Biological Sciences, University of Keele, Staffs ST5 5BG. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 106, Issue 3, 1 March 1982, Pages 299–302, https://doi.org/10.1111/j.1365-2133.1982.tb01727.x Published: 01 March 1982 Article history Accepted: 18 May 1981 Published: 01 March 1982