tbuckley/cabot-search huggingface dataset:
Weight loss and achievement of minimal disease activity in patients with psoriatic arthritis starting treatment with tumour necrosis factor α blockers
Authors: Matteo Nicola Dario Di Minno, Rosario Peluso, Salvatore Iervolino, Anna Russolillo, Roberta Lupoli, Raffaele Scarpa
Journal: Annals of the Rheumatic Diseases (2013)

To evaluate prospectively the effect of weight loss on the achievement of minimal disease activity (MDA) in overweight/obese patients with psoriatic arthritis (PsA) starting treatment with tumour necrosis factor α (TNFα) blockers.Among subjects with PsA starting treatment with TNFα blockers, 138 overweight/obese patients received a concomitant dietary intervention (69 a hypocaloric diet (HD) and 69 a free-managed diet (FD)). Changes in metabolic variables were measured and a complete clinical rheumatological evaluation was made in all patients at baseline and after a 6-month follow-up to define the achievement of MDA.126 subjects completed the study. MDA was more often achieved by HD than by FD subjects (HR=1.85, 95% CI 1.019 to 3.345, p=0.043). A diet was successful (≥5% weight loss) in 74 (58.7%) patients. Regardless of the type of diet, after 6 months of treatment with TNFα blockers, ≥5% of weight loss was a predictor of the achievement of MDA (OR=4.20, 95% CI 1.82 to 9.66, p<0.001). For increasing weight-loss categories (<5%, 5-10%, >10%), MDA was achieved by 23.1%, 44.8% and 59.5%, respectively. A higher rate of MDA achievement was found in subjects with 5-10% (OR=3.75, 95% CI 1.36 to 10.36, p=0.011) and in those with >10% (OR=6.67, 95% CI 2.41 to 18.41, p<0.001) weight loss in comparison with those with <5% weight loss.Regardless of the type of diet, a successful weight loss (≥5% from baseline values) is associated with a higher rate of achievement of MDA in overweight/obese patients with PsA who start treatment with TNFα blockers.
Impact of cytokine gene variants on the prediction and prognosis of hepatocellular carcinoma in patients with cirrhosis
Authors: Arige Tarhuni, Erwan Guyot, Pierre Rufat, Angela Sutton, Valérie Bourcier, Véronique Grando, Nathalie Ganne-Carrié, Marianne Ziol, Nathalie Charnaux, Michel Beaugrand, Richard Moreau, Jean-Claude Trinchet, Abdellah Mansouri, Pierre Nahon
Journal: Journal of Hepatology (2014)
Dermatitis from Optical Whiteners
Authors: R. Mason Bolam
Journal: British Journal of Dermatology (1970)

Journal Article Dermatitis from Optical Whiteners Get access R. Mason Bolam R. Mason Bolam The Royal Victoria Infirmary, Newcastle upon Tyne Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 82, Issue 4, 1 April 1970, Page 421, https://doi.org/10.1111/j.1365-2133.1970.tb06847.x Published: 01 April 1970
Effect of Calcium on Force-Velocity-Length Relations of Heart Muscle of the Cat
Authors: DIRK L. BRUTSAERT, VICTOR A. CLAES, MARK A. GOETHALS
Journal: Circulation Research (1973)

The influence of calcium concentration in the bathing solution on the force-velocity relations of the isolated, electrically excited cat papillary muscle was examined. Shortening velocity was directly measured at minimum loads by unloading or load clamping the muscle from the preload (at the length, Lmax, where maximum active tensio was developed) to 0 (zero-load clamp), 2, 5, 10, and 15% of the total tension, P 0 . All measurements were made in the physiological length range between Lmax and 12.5% below Lmax. Increasing the calcium concentration augmented the measured maximum unloaded shortening velocity and shifted the normalized force-velocity relation when force was expressed as a fraction of P 0 . These observations suggest that the activating calcium has an action more complex than the binding to troponin alone.
Impact of various rice based cropping systems on soil fertility
Authors: S. Porpavai, P. Devasenapathy, K. Siddeswaran, T. Jayaraj
Journal: Journal of Clinical Oncology (2011)

Field experiments with ten cropping systems were evaluated during 2002 to 2006 at Soil and Water Management Research Institute, Thanjavur, Tamil Nadu, India during Kharif (June to Sep), rabi (Oct to Jan) and summer seasons (Feb to Apr). The cropping systems were evaluated for their productivity, and to assess their effect on the soil organic carbon content and soil available nitrogen. Inclusion of legumes in the cropping system improved the organic carbon status of the soil. The cropping systems rice (Oryza sativa) – rice – blackgram (Vigna mungo), onion (Allium cepa) – rice – blackgram, groundnut (Arachis hypogea)– rice – blackgram and rice – rice – greengram, (Vigna radiata) improved the soil organic carbon content and soil available N status. Inclusion of blackgram and greengram in rice based cropping system increased the yield of succeeding crop of rice.

	 

	Key words: Cropping systems, soil organic carbon, soil available N.
Aortobronchial fistula after correction of congenital cardiovascular abnormalities
Authors: SC Hiep-van Casteren, CJ Westermann, RP Hamerlijnck, PH Cornelissen, TT Overtoom
Journal: European Respiratory Journal (1995)

Aortobronchial fistula (ABF) is a rare but highly lethal condition. Four patients with ABF, 10-25 years after surgical repair of a congenital cardiovascular abnormality are reported. All patients presented with haemoptysis. Computed tomographic (CT) scan and aortography were inconclusive in two, diagnostic in one and not performed in another. Three patients underwent operation: all survived and are free of symptoms with a follow-up of 2-8 yrs. The fourth patient died before operation due to massive haemorrhage into the lung. In all patients, the fistula was secondary to aortic interposition of patch grafts.
Life-threatening haemoptysis due to tracheal varices secondary to pulmonary vein obstruction
Authors: Karim Hani Kamel Morcos, Giles Roditi, Stewart Craig
Journal: Thorax (2013)

A 30-year-old man with a 3 day history of increasing breathlessness and frank haemoptysis was suspected of having pulmonary embolism and anticoagulated with heparin. Haemoptysis worsened so anticoagulation was reversed and he was transferred to our institution.

Pulmonary and bronchial angiography revealed a small right pulmonary artery and a prominent right intercostobronchial trunk which was embolised. However, haemoptysis recurred and a contrast enhanced ECG-gated CT scan confirmed a hypoplastic right pulmonary artery and showed thrombosed right pulmonary veins that had no communication to the left atrium, a ‘bulky’ right hilum and thickened bronchial walls with smooth mucosal indentations into the airway lumen …
The response to procainamide during electrophysiologic study for sustained ventricular tachyarrhythmias predicts the response to other medications.
Authors: H L Waxman, A E Buxton, L M Sadowski, M E Josephson
Journal: Circulation (1983)

We evaluated 126 patients with inducible sustained ventricular tachyarrhythmias to assess whether the response to procainamide during electrophysiologic study could predict responses to other conventional antiarrhythmic agents and combinations of agents. Thirty of 42 patients in whom tachycardia was not inducible after the administration of procainamide and 69 of 84 patients in whom ventricular tachycardia was inducible after procainamide underwent serial electrophysiologic studies. Forty-three of 67 antiarrhythmic regimens (64%) tested in the patients in whom ventricular tachycardia could not be induced after procainamide prevented induction of ventricular tachycardia, compared with 10 of 145 regimens (7%) tested in the patients in whom ventricular tachycardia could be induced after procainamide. Sixty of the 69 patients in whom ventricular tachycardia remained inducible after procainamide had ventricular tachycardia induced on all other conventional antiarrhythmic regimens tested. By comparison, of the 30 patients in whom ventricular tachycardia became noninducible after procainamide, 25 had no ventricular tachycardia inducible on at least one other antiarrhythmic regimen tested. Thus, the response to procainamide accurately predicted the response to other conventional antiarrhythmic agents during electrophysiologic study.
IL-10 induces aberrant deletion of dendritic cells by natural killer cells in the context of HIV infection
Authors: Galit Alter, Daniel Kavanagh, Suzannah Rihn, Rutger Luteijn, David Brooks, Michael Oldstone, Jan van Lunzen, Marcus Altfeld
Journal: Journal of Clinical Investigation (2010)

Persistent levels of IL-10 play a central role in progressive immune dysfunction associated with chronic viral infections such as HIV, but the underlying mechanisms are poorly understood. Because IL-10 affects the phenotypic and functional properties of DCs, which are responsible for initiating adaptive immune responses, we investigated whether IL-10 induces changes in DC phenotype and function in the context of HIV infection. Here, we show that IL-10 treatment of immature and mature human DCs in culture induced contrasting phenotypic changes in these populations: immature DCs exhibited aberrant resistance to NK cell-mediated elimination, whereas mature DCs exhibited increased susceptibility to NKG2D-dependent NK elimination. Treatment of immature and mature DCs with HIV resulted in potent IL-10 secretion and the same phenotypic and functional changes observed in the IL-10-treated cells. Consistent with these in vitro data, LNs isolated from individuals infected with HIV exhibited aberrant accumulation of a partially "immature" DC population. Together, these data suggest that the progressive immune dysfunction observed in chronic viral infections might be caused in part by IL-10-induced reversal of DC susceptibility to NK cell-mediated elimination, resulting in the accumulation of poorly immunogenic DCs in LNs, the sites of adaptive immune response induction.
Lessons from Geographic Variations in Predialysis Nephrology Care
Authors: Wolfgang C. Winkelmayer
Journal: Journal of the American Society of Nephrology (2009)

Inadequate access to nephrology subspecialists among patients with advanced chronic kidney disease (CKD) is one of the major public health problems of our discipline. Depending on its definition and the specific geographic and health care setting, between 20 and 66% of patients reaching ESRD do not see a nephrologist in a timely manner to receive adequate management of their progressive kidney failure or the long-term complications of advancing CKD. These patients are also robbed of their ability to receive appropriate education to make informed choices about their preferred treatment modality and to prepare optimally for the treatment option they choose. Thus, it has been shown in numerous countries and health care systems that delayed nephrologic care for patients with advanced CKD is associated with inadequate quality of care during transition from CKD to ESRD and with inferior outcomes on renal replacement therapy (RRT).

Patients who have CKD and experience inadequately late nephrologic care are less likely to initiate RRT using peritoneal dialysis,1 and, when they do, their chances for a technique failure increase.2 When they start RRT using hemodialysis, patients seen inadequately late by a nephrologist are more likely to require temporary or tunneled central venous catheterization and are less likely to use a more preferable peripheral access, particularly arteriovenous fistulas, for initiation of dialysis thereafter.3, …
MiR-96 Downregulates REV1 and RAD51 to Promote Cellular Sensitivity to Cisplatin and PARP Inhibition
Authors: Yemin Wang, Jen-Wei Huang, Philamer Calses, Christopher J. Kemp, Toshiyasu Taniguchi
Journal: Cancer Research (2012)

Abstract Cell survival after DNA damage relies on DNA repair, the abrogation of which causes genomic instability. The DNA repair protein RAD51 and the trans-lesion synthesis DNA polymerase REV1 are required for resistance to DNA interstrand cross-linking agents such as cisplatin. In this study, we show that overexpression of miR-96 in human cancer cells reduces the levels of RAD51 and REV1 and impacts the cellular response to agents that cause DNA damage. MiR-96 directly targeted the coding region of RAD51 and the 3′-untranslated region of REV1. Overexpression of miR-96 decreased the efficiency of homologous recombination and enhanced sensitivity to the PARP inhibitor AZD2281 in vitro and to cisplatin both in vitro and in vivo. Taken together, our findings indicate that miR-96 regulates DNA repair and chemosensitivity by repressing RAD51 and REV1. As a therapeutic candidate, miR-96 may improve chemotherapeutic efficacy by increasing the sensitivity of cancer cells to DNA damage. Cancer Res; 72(16); 4037–46. ©2012 AACR.
Acute focal infections of dental origin
Authors: Ingar Olsen, Arie J. van Winkelhoff
Journal: Periodontology 2000 (2014)

Abstract This article describes the most important pus‐producing acute oral infections (dental infections) that can spread extra‐orally. Most of these infections are spread by bacteria entering the bloodstream. However, dental infections have a number of other pathways for dissemination. By forming abscesses or phlegmon they can reach facial spaces that communicate with each other and then spread downwards to the mediastinum or upwards to the brain. In such cases dental infections can become, if not properly treated, life‐threatening. It seems that early diagnosis and treatment are imperative, and potentially infectious foci should be traced and eliminated. Dental hygiene and prophylaxis to prevent dental biofilm formation are important measures to reduce the risk of these calamities. The more compromised the host defense is, the more importance should be put on these measures. Although commensal bacteria are often involved in these infections, attention should also be paid to specific periodontal pathogens, and a proper microbial diagnosis, obtained using molecular methods plus bacterial sensitivity testing, can provide the patient with optimal care. Drainage of pus must be established where possible so that the optimal effect of antibiotics can be achieved. Penicillin is still the drug of first choice in settings where suspicion of methicillin‐resistant Staphylococcus aureus is low.
People with Rheumatic Diseases Experiences of Health-Promoting Self-Care
Authors: Susann Arvidsson, Stefan Bergman, Barbro Arvidsson, Bengt Fridlund, Anita Bengtsson-Tops
Journal: Annals of the Rheumatic Diseases (2010)

Background: People with rheumatic diseases estimate their health status low. The health status and health belief are influencing the choice of self-care behaviours. Self-care behaviours are common  ...
Transparent Reporting of a Multivariable Prediction Model for Individual Prognosis or Diagnosis (TRIPOD)
Authors: Gary S. Collins, Johannes B. Reitsma, Douglas G. Altman, Karel G.M. Moons
Journal: Circulation (2015)

Prediction models are developed to aid health care providers in estimating the probability or risk that a specific disease or condition is present (diagnostic models) or that a specific event will occur in the future (prognostic models), to inform their decision making. However, the overwhelming evidence shows that the quality of reporting of prediction model studies is poor. Only with full and clear reporting of information on all aspects of a prediction model can risk of bias and potential usefulness of prediction models be adequately assessed.
GM-CSF with biochemotherapy (cisplatin, DTIC, tamoxifen, IL-2 and interferon-alpha): A phase I trial in melanoma
Authors: M.M. Vaughan, J. Moore, P.G. Riches, S.R.D. Johnston, R.P. A'Hern, M.E. Hill, T. Eisen, M.J. Ayliffe, J.M. Thomas, M.E. Gore
Journal: Annals of Oncology (2000)
Endothelial L-Selectin Ligands in Sinus Mucosa during Chronic Maxillary Rhinosinusitis
Authors: Sanna K. Toppila-Salmi, Jyri P. Myller, Tommi V. M. Torkkeli, Jarkko V. Muhonen, Jutta A. Renkonen, Markus E. Rautiainen, Risto L. O. Renkonen
Journal: American Journal of Respiratory and Critical Care Medicine (2005)

Chronic rhinosinusitis is characterized by persistent inflammation of the nasal and paranasal mucosa with numerous emigrated leukocytes. L-selectin on leukocytes and its endothelial glycosylated ligands initiate organ-specific leukocyte infiltration into inflamed tissues.The purpose of this study was to evaluate the endothelial expression of functionally active endothelial L-selectin ligands, sulfated sialyl Lewis x, in maxillary sinus mucosa from patients with chronic rhinosinusitis and from normal control subjects.Maxillary sinus mucosa specimens (116) were obtained surgically and immunohistochemically stained with monoclonal antibodies detecting sialyl Lewis x or sulfated extended core 1 lactosamines. The severity of the inflammation was determined by intraoperative endoscopic findings, computed tomography scans, and histopathologic assessment of the specimens.The percentage of vessels expressing endothelial sulfated sialyl Lewis x epitopes increased during chronic rhinosinusitis compared with uninflamed control tissue, especially in patients with additional allergic rhinitis, and decreased in specimens from aspirin-intolerant patients with preoperative oral corticosteroid treatment. In addition, the expression level of endothelial sulfated sialyl Lewis x epitopes and the number of mucosal eosinophils correlated with the severity of the inflammation, and decreased in specimens taken 9 months postoperatively compared with intraoperative samples, especially in patients with intranasal corticosteroid treatment.Our results suggest that functionally active L-selectin ligands might guide leukocyte traffic into maxillary sinus mucosa preferentially in patients with severe findings of chronic maxillary rhinosinusitis, thus leading to aggravation of the inflammation.
Circulating Surfactant Protein A (SP-A), a Marker of Lung Injury, Is Associated With Insulin Resistance
Authors: José Manuel Fernández-Real, Berta Chico, Masanori Shiratori, Yusuke Nara, Hiroki Takahashi, Wifredo Ricart
Journal: Diabetes Care (2008)

Impaired lung function and inflammation have both attracted interest as potentially novel risk factors for glucose intolerance, insulin resistance, and type 2 diabetes. We hypothesized that circulating levels of surfactant protein (SP)-A, which reflects interstitial lung injury, could be associated with altered glucose tolerance and insulin resistance.Circulating SP-A concentration and metabolic variables (including insulin sensitivity by minimal model method, n = 89) were measured in 164 nonsmoking men.Circulating SP-A concentration was significantly higher among patients with glucose intolerance and type 2 diabetes than in subjects with normal glucose tolerance, even after adjustment for BMI, age, and smoking status (ex/never). The most significant differences were found in overweight and obese subjects with altered glucose tolerance (n = 59) who showed significantly increased serum SP-A concentrations (by a mean of 24%) compared with obese subjects with normal glucose tolerance (n = 58) (log SP-A 1.54 +/- 0.13 vs. 1.44 +/- 0.13; P < 0.0001). Insulin sensitivity (P = 0.003) contributed independently to 22% of SP-A variance among all subjects. In subjects with altered glucose tolerance, insulin sensitivity (P = 0.01) and fasting triglycerides (P = 0.02) contributed to 37% of SP-A variance. Controlling for serum creatinine or C-reactive protein in these models did not significantly change the results.Lung-derived SP-A protein was associated with altered glucose tolerance and insulin resistance in 164 nonsmoking men.
Citrulline increases arginine pools and restores nitrogen balance after massive intestinal resection
Authors: S Osowska
Journal: Gut (2004)

Arginine supplementation seems logical in situations where this amino acid becomes essential, for example after massive intestinal resection. Arginine is taken up and metabolised by the liver to a large extent and its supplementation is potentially unsafe. Citrulline is not captured by the liver and passes freely to the kidneys where it is metabolised to arginine, and so is a good candidate to generate arginine and thereby improve nutritional status.Twenty four rats were assigned to four groups: citrulline, arginine, control, and sham. The sham group underwent transection and the three other groups resection of 80% of the small intestine. All rats were fed by enteral nutrition and its composition was as follows: supplementation with citrulline in the citrulline group, supplementation with arginine in the arginine group, and standard polymeric enteral nutrition in the control and sham groups. All groups received isonitrogenous nutrition and citrulline and arginine intakes were equimolar in their respective groups. After 10 days, the rats were sacrificed.Arginine concentration was higher (p<0.05) in plasma and muscle in the citrulline group than in the three other groups. Plasma levels of arginine were 110 (12), 79 (7), 167 (22), and 228 (13) mumol/l in the sham, control, arginine, and citrulline groups respectively. Arginine concentrations in the gastrocnemius were: 0.15 (0.02), 0.16 (0.02), 0.40 (0.05), and 0.94 (0.20) mumol/g, respectively. Citrulline preserved nitrogen balance in resected rats but not in arginine supplemented rats (mean J10: 2.27 (0.29), 1.67 (0.15), 1.98 (0.29), and 2.43 (0.41) g/24 hours in the sham, control, arginine, and citrulline groups, respectively).Supplementing the diet with citrulline is a very efficient means of increasing arginine levels and improving nitrogen balance after massive intestinal resection. The results of this study form a strong rationale for citrulline supplementation in these patients.
Adipose-derived cardiomyogenic cells: in vitro expansion and functional improvement in a mouse model of myocardial infarction
Authors: Bertrand Léobon, Jérôme Roncalli, Carine Joffre, Manuel Mazo, Marie Boisson, Corinne Barreau, Denis Calise, Emmanuelle Arnaud, Mireille André, Michel Pucéat, Luc Pénicaud, Felipe Prosper, Valérie Planat-Bénard, Louis Casteilla
Journal: Cardiovascular Research (2009)

Cells derived from the stroma vascular fraction (SVF) of mouse adipose tissue can spontaneously give rise to rare, functional, cardiac-like cells in vitro. This study aimed to improve the production of adipose-derived cardiomyogenic cells (AD-CMG), to characterize them and to assess their cardiac fate and functional outcomes after their administration in a mouse model of acute myocardial infarction. The culture process optimized to improve in vitro cardiac specification consisted of a primary culture of murine SVF cells in semi-solid methylcellulose medium, a selection of AD-CMG cell clusters, and a secondary culture and expansion in BHK21 medium. AD-CMG cells were CD29+, CD31−, CD34−, CD44+, CD45−, CD81+, CD90−, CD117−, and Flk-1− and expressed several cardiac contractile proteins. After 1, 2, and 4 weeks of their injection in mice having acute myocardial infarction, a strong presence of green fluorescent protein-positive cells was identified by immunohistochemistry as well as quantitative polymerase chain reaction. Echocardiography showed a significant reduction of remodelling and stability of left ventricle ejection fraction in the AD-CMG cell-treated group vs. controls. Vascular density analysis revealed that AD-CMG administration was also associated with stimulation of angiogenesis in peri-infarct areas. Cardiomyogenic cells can be selected and expanded in large amounts from mouse adipose tissue. They can survive and differentiate in an acute myocardial infarction model, avoiding remodelling and impairment of cardiac function, and can promote neo-vascularization in the ischaemic heart.