Co-trimoxazole Desensitization in Bone Marrow Transplantation
Authors: THOMAS E. HUGHES
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 July 1986Co-trimoxazole Desensitization in Bone Marrow TransplantationTHOMAS E. HUGHES, B.S., JEFFREY D. ALMGREN, B.S., ROBERT W. MCGUFFIN, M.D., ROBERTA J. OMOTO, M.D.THOMAS E. HUGHES, B.S.Search for more papers by this author, JEFFREY D. ALMGREN, B.S.Search for more papers by this author, ROBERT W. MCGUFFIN, M.D.Search for more papers by this author, ROBERTA J. OMOTO, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-105-1-148 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Co-trimoxazole (trimethoprim sulfamethoxazole) is a safe and effective oral anti-infective agent commonly used in recipients of bone marrow transplants for prophylaxis against infection, particularlyPneumocystis cariniipneumonia. Since the institution of co-trimoxazole as a prophylactic agent, the morbidity ofP. cariniiinterstitial pneumonia has decreased (1, 2). However, the occurrence of a hypersensitivity reaction to co-trimoxazole can prevent its administration. Penicillin V may be substituted for bacterial prophylactic coverage after transplantation, but it is not effective against P. carinii. Successful desensitization to co-trimoxazole would permit continued use of this most effective agent for prophylaxis or treatment of...References1. MEYERSATKINSON JK. Infection in bone marrow transplantation. Clin Haematol. 1983;12:791-811. CrossrefMedlineGoogle Scholar2. MEYERSTHOMAS JE. Infection complicating bone marrow transplantation. In: Young LS, Rubin RH, eds. Clinical Approach to Infection in Immunocompromised Hosts. New York: Plenum Medical Books; 1982:507-51. Google Scholar3. PATTERSONANDERSON RJ. Allergic reactions to drugs and biologic agents. JAMA. 1982;248:2637-45. CrossrefMedlineGoogle Scholar4. MATHEWS K. Clinical spectrum of allergic and pseudoallergic drug reactions. J Allergy Clin Immunol. 1984;74(4 part 2):558-66. CrossrefMedlineGoogle Scholar5. SULLIVAN T. Allergic reactions to antimicrobial agents: a review of reactions to drugs not in the beta-lactam antibiotic class. J Allergy Clin Immunol. 1984;74(4 part 2):594-9. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: THOMAS E. HUGHES, B.S.; JEFFREY D. ALMGREN, B.S.; ROBERT W. MCGUFFIN, M.D.; ROBERTA J. OMOTO, M.D.Affiliations: Seattle Veterans Administration Medical Center Seattle, WA 98108 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDrug allergy: A 2022 practice parameter updateSulfonamide desensitization in solid organ transplant recipients: A protocol‐driven approach during the index transplant hospitalizationSulfonamide Hypersensitivity: Fact and FictionSulfonamide Drug AllergySuccessful desensitization protocol for hypersensitivity reaction probably caused by dabrafenib in a patient with metastatic melanoma: Table 1.Successful Outpatient Graded Administration of Trimethoprim-Sulfamethoxazole in Patients Without HIV and With a History of Sulfonamide Adverse Drug ReactionDesensitization to imatinib in patients with leukemiaA 5-day course of oral desensitization to trimethoprim/sulfamethoxazole (T/S) in patients with human immunodeficiency virus type-1 infection who were previously intolerant to T/STolerance induction to cotrimoxazoleTrimethoprim/Sulfamethoxazole DesensitizationDesensitization to trimethoprim/sulfamethoxazole in HIV-infected patientsISSUES IN TOXOPLASMOSISManagement of the patient with allergic reactions to antibioticsDesensitization to sulfonamides in patients with HIV infectionPneumocystis cariniiTrimethoprim-sulfamethoxazole desensitization in AIDSTrimethoprim-Sulfamethoxazole Desensitization in the Acquired Immunodeficiency SyndromeR. MACLEAN SMITH, M.D., GARY K. IWAMOTO, M.D., HAL B. RICHERSON, M.D., JOHN P. FLAHERTY, M.D. 1 July 1986Volume 105, Issue 1Page: 148-148KeywordsAntimicrobialsBone marrowBone marrow transplantationHypersensitivityInterstitial lung diseasesMorbidityPenicillinPneumocystis carinii pneumoniaProphylaxisTransplantation ePublished: 1 December 2008 Issue Published: 1 July 1986 PDF downloadLoading ...