tbuckley/cabot-search huggingface dataset:
Motion in Cardiovascular Radiography
Authors: CHARLES T. DOTTER
Journal: Circulation (1955)

The minute has given way to the second as an expression of radiographic exposure duration. It is predicted that the millisecond will be the term of the future. Arterial blood velocity exceeds 50 cm. per second. In cardiovascular radiography, especially angiocardiography, maximum detail cannot be achieved unless the x-ray exposure is short enough to "stop" rapid movement. Practical experience indicates that exposures of 3 milliseconds' duration offer an economic alternative to high speed, serial angiocardiography. A method of achieving such exposures consists of a grid-controlled, hightension, switch tube operated in series with the diagnostic x-ray tube.
Does etretinate exacerbate scabies?
Authors: A. Zlotogorski, V. Leibovici
Journal: British Journal of Dermatology (1987)

Journal Article Does etretinate exacerbate scabies? Get access A. Zlotogorski, A. Zlotogorski Department of Dermatology, Hadassah University Hospital, Jerusalem, Israel Search for other works by this author on: Oxford Academic Google Scholar V. Leibovici V. Leibovici Department of Dermatology, Hadassah University Hospital, Jerusalem, Israel Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 116, Issue 6, 1 June 1987, Page 882, https://doi.org/10.1111/j.1365-2133.1987.tb04915.x Published: 01 June 1987
The role of integrin α2 in cell and matrix therapy that improves perfusion, viability and function of infarcted myocardium
Authors: Ali Ahmadi, Brian McNeill, Branka Vulesevic, Myra Kordos, Laura Mesana, Stephanie Thorn, Jennifer M. Renaud, Emily Manthorp, Drew Kuraitis, Hadi Toeg, Thierry G. Mesana, Darryl R. Davis, Rob S. Beanlands, Jean N. DaSilva, Robert A. deKemp, Marc Ruel, Erik J. Suuronen
Journal: Biomaterials (2014)
Mosaic overgrowth with fibroadipose hyperplasia is caused by somatic activating mutations in PIK3CA
Authors: Marjorie J Lindhurst, Victoria E R Parker, Felicity Payne, Julie C Sapp, Simon Rudge, Julie Harris, Alison M Witkowski, Qifeng Zhang, Matthijs P Groeneveld, Carol E Scott, Allan Daly, Susan M Huson, Laura L Tosi, Michael L Cunningham, Thomas N Darling, Joseph Geer, Zoran Gucev, V Reid Sutton, Christos Tziotzios, Adrian K Dixon, Timothy Helliwell, Stephen O'Rahilly, David B Savage, Michael J O Wakelam, Inês Barroso, Leslie G Biesecker, Robert K Semple
Journal: Nature Genetics (2012)
Abstract 1405: Mesothelin enhances ovarian cancer invasion of by inducing MMP-7 through MAPK/ERK and JNK pathways
Authors: Ming-Cheng Chang, Chi-An Chen, Ying-Cheng Chiang, Tzer-Ming Chen, Wen-Fang Cheng
Journal: Cancer Research (2011)

Abstract Ovarian cancer is a cancer of high mortality in women malignancies. Little is known with its property of tumor progression and no effective molecule could monitor the tumor growth or therapeutic responses of this disease. In our previous studies, we first identified that mesothelin, a secreted protein, over-expressed in ovarian cancer tissues with a poor clinical outcome in chemotherapeutic response of ovarian cancer patients. Besides, mesothelin activated PI3K/Akt signaling to inhibit paclitaxel-induced apoptosis. Here, we investigated the mechanism of mesothelin enhancing the invasion of ovarian cancer and the correlation between mesothelin and metastatic diseases. The expression of mesothelin correlated well with expression of MMP-7 in human ovarian cancer tissues. Mesothelin over-expressed or mesothelin-treated ovarian cancer cells could enhance the migration and invasion of cancer cells through the activation of MMP-7. Mesothelin could regulate the expression of MMP-7 through ERK (extracellular-signal-regulated kinase) 1/2, Akt (phosphoinositide 3-kinase), and JNK (c-jun-N-terminal kinase) pathways. The MMP-7 expression and the migrating ability of mesothelin-treated ovarian cancer cells can be suppressed by the ERK1/2 or JNK specific inhibitor, or decoy AP-1 oligonucleotide in in vitro experiments. The in vivo animal experiments also demonstrated that mice treated with MAPK/ERK or JNK- specific inhibitor could decrease the itnratumoral MMP-7 expression and delay the tumor growth. We concluded that mesothelin enhances ovarian cancer invasion by MMP-7 expression through the MAPK/ERK and JNK signal transduction pathways. And blocking these two pathways can be a potential strategy to inhibit the tumor growth of ovarian cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1405. doi:10.1158/1538-7445.AM2011-1405
Chemotherapy of Solid Carcinoma
Authors: John D. Hurley
Journal: JAMA (1960)

Cancer chemotherapy is indicated in patients who are considered fair risks, have primary inoperable or recurrent tumors, and have not been relieved by conventional therapy including palliative surgery and hormone therapy. It is contraindicated when there is much debility and wasting and when the tumor is known not to respond to the proposed agent. In this study of 500 patients, three alkylating agents (nitrogen mustard, triethylene melamine, and triethylene thiophosphoramide) and three antimetabolic agents (methotrexate, 6-mercaptopurine, and 5-fluorouracil) were used. The best results were obtained in cases of breast carcinoma, which manifested a beneficial response for two or more months in 60 cases out of 100. Esophageal carcinomas did not respond to any of these six agents.
Insulin resistance predicts response to peginterferon-alpha/ribavirin combination therapy in chronic hepatitis C patients
Authors: Chia-Yen Dai, Jee-Fu Huang, Ming-Yen Hsieh, Nai-Jen Hou, Zu-Yau Lin, Shinn-Chern Chen, Ming-Yuh Hsieh, Liang-Yen Wang, Wen-Yu Chang, Wan-Long Chuang, Ming-Lung Yu
Journal: Journal of Hepatology (2009)
A TWO-YEAR EVALUATION OF CHLORPROMAZINE IN CLINICAL RESEARCH AND PRACTICE
Authors: SIDNEY MALITZ, PAUL H. HOCH, STANLEY LESSE
Journal: American Journal of Psychiatry (1956)

In conclusion, we believe that chlorpromazine has established itself as a useful therapeutic tool in the treatment of mental illness. It is a relatively safe drug, and although the side-effects are many, serious or permanent sequelae are almost unknown. In regard to its therapeutic effect in our case material much is left to be desired. Its range of application appears to be narrow, being most effective in agitated, hyperactive, and overtly anxious patients, with much more limited value in depression, or with obsessive patients manifesting little or no increase in motor function. It is palliative rather than curative. It can intensify anxiety and precipitate depression and psychotic symptoms as well as alleviate them. Its major advantage lies in its tranquilizing action without accompanying marked drowsiness or confusion. Its value as an adjunct to psychotherapy is still to be evaluated. Chlorpromazine has been a major force in firmly launching us into the era of psychopharmacology. We are still suffering, however, from all the uncertainties and hesitation of a pioneer venture. This should not deter us from continued investigation and progress.
Temporary gastro-electrical stimulation improves gastric emptying and quality of life in patients with refractory gastroparesis
Authors: S. Gibson, L. Clark, N. Jamieson, G. Fullarton
Journal: Gut (2011)

<h3>Introduction</h3> Gastro-electrical stimulation (GES) is an accepted method of managing severe drug refractory gastroparesis. Temporary GES may help select which patients would most benefit from the permanent GES treatment; however, data on the practicality and efficacy of temporary GES are lacking. The aim of this study was to determine the efficacy of temporary GES in patients with refractory gastroparesis. <h3>Methods</h3> Patients with confirmed drug refractory gastroparesis (t ½ &gt; 90 m) were selected for temporary GES. Pre-procedure gastric isotope emptying data, and visual analogue symptom score were prospectively gathered. A temporary GES electrode (model 6414-200 Medtronic Ltd) was inserted endoscopically into the gastric antrum and secured with an Olympus Quickclip (Olympus Corp). Electrodes were then secured trans-nasally and connected to an external GES device (Enterra, Medtronic Ltd) set at 14 Hz frequency and standard amplitude (5–10 mA). Post-procedure gastric isotope emptying studies were repeated on day 4 and patients provided daily symptom scores on a visual analogue scale. Patients scored overall well-being on a scale of −3 (worst) to +3 (best). Nausea and vomiting were judged by patients on a scale of 0 (best) to 4 (worst). <h3>Results</h3> Some 22 patients underwent insertion of a temporary GES electrode with no associated morbidity. Median patient age was 41 (17–62). 17 of the 22 cases of gastroparesis were idiopathic in nature, 3 were post-surgical and 2 were diabetic. Gastric isotope emptying time (t ½) improved in 16/22 patients (73%). The median (interquartile range) pre-operative gastric isotope emptying time (t ½) (minutes) was 251 (139.5–388.5) versus 100.5 (45.5–137) post-operatively (p = 0.005). The overall score of well-being improved in 18/19 patients (95%). The median pre-procedure score was −3 versus 2 post-procedure (p &lt; 0.001). Symptoms of vomiting improved in 14 of 19 patients (74%). Median vomiting score was 3 pre-operatively versus 0 post-operatively (p &lt; 0.001). Symptoms of nausea improved in all 18 patients completing this aspect of the questionnaire with the median score pre-procedure 3 versus 0.5 post-procedure (p &lt; 0.001). Symptoms of pain, early satiety and bloating also demonstrated improvement post procedure. <h3>Conclusion</h3> Temporary GES improves gastric emptying, symptoms and perception of well-being in patients with refractory gastroparesis. The longer-term outcome of permanent GES in these patients is yet to be confirmed.
Health Promotion: Principles and Clinical Applications
Authors: Suzanne W. Fletcher
Journal: JAMA (1982)

Physicians interested in encouraging health promotion activities among their patients have been hampered by the lack of handy references summarizing the health promotion literature and outlining the various strategies and techniques that can be used by individual practitioners. This clearly written and readable book sets out to fill that void. The book gives an overview of epidemiologic, biomedical, statistical, behavioral, and educational principles of health promotion and information about specific applications (in this case, nutrition, weight control, exercise, alcohol use, invalidating tobacco, the appropriate use of drugs, rest and sleep, and stress management). A distinction is made between health promotion activities, ie, efforts to influence patients' health behaviors, and preventive medicine activities, ie, efforts to prevent or detect early specific medical conditions. It is important to understand that the book does not cover the latter. The first section covers principles of health promotion. The chapter on the Health Hazard Appraisal
Spontaneous Gallstone Migration Followed by Endoscopic Retrograde Cholangiography
Authors: M. Tanaka, S. Ikeda
Journal: Endoscopy (1980)

A case in which a medium-sized common bile duct stone spontaneously passed through the papilla into the duodenum is presented. The naturel course of this patient was followed by repeated endoscopic retrograde cholangiography. Acute ulcerous changes caused by the passage of a gallstone and a surprisingly quick recovery are demonstrated by vivid illustrations. The clinical significance of the phenomenon with regard to the patulous sphincter of Oddi or, in contrast, papillary stenosis, is discussed.
Effect of surgical cleaning of the skin on the pathergy phenomenon in Behcet's syndrome.
Authors: I Fresko, H Yazici, M Bayramiçli, S Yurdakul, C Mat
Journal: Annals of the Rheumatic Diseases (1993)

To assess the effect of surgical cleaning of the skin on the pathergy phenomenon in Behçet's syndrome. The pathergy phenomenon was assessed in 183 patients with Behçet's syndrome in a single blind study at 48 hours after a needle prick of the forearm skin, cleaned in the conventional way with alcohol, with 10% povidine iodine, with 100% chlorhexidine, and with a 4% aqueous solution of chlorhexidine. The surgical cleaning of the forearm with povidone iodine before the application of the needle prick reduced the prevalence of the pathergy reaction to 27% from 48% in the conventionally (by alcohol swab) cleaned forearm. Cleaning the forearm with 100% chlorhexidine reduced the prevalence of the pathergy to 36% from 59% in the conventionally cleaned forearm. No significant changes were observed with a 4% aqueous solution of chlorhexidine. Surgical cleaning of the skin with disinfectants of various concentrations reduces the prevalence of a positive pathergy test in Behçet's syndrome. This implies that more than the disruption of the structural integrity of the dermis and epidermis is involved in the production of the pathergy phenomenon in Behçet's syndrome.
PSORIASIS OF THE NAILS
Authors: JOHN ALKIEWICZ
Journal: British Journal of Dermatology (1948)

Journal Article PSORIASIS OF THE NAILS Get access JOHN ALKIEWICZ, M.D. JOHN ALKIEWICZ, M.D. Assistant Professor, University of Poznan Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 60, Issue 6, 1 June 1948, Pages 195–200, https://doi.org/10.1111/j.1365-2133.1948.tb11026.x Published: 01 June 1948
Immune thrombocytopenia attributed to brucellosis and other mechanisms of <i>Brucella</i>‐induced thrombocytopenia
Authors: G. Pappas, M. Kitsanou, L. Christou, E. Tsianos
Journal: American Journal of Hematology (2004)

Abstract Thrombocytopenia often complicates the course of acute brucellosis, mainly due to bone marrow suppression or hypersplenism. Immune thrombocytopenia is also reported in brucellosis, resulting usually in massive thrombocytopenia, purpura, and spontaneous hemorrhage. We describe a case of acute brucellosis in an 85‐year old woman, who presented with fever, purpuric skin lesions, anemia, and rhinorrhagia. The absolute platelet count was 1000/μL. Direct and indirect Coombs tests were positive, and a cold‐agglutinin was detected. The patient was diagnosed as suffering from brucellosis on the basis of a strongly positive serologic reaction and was treated with doxycycline, streptomycin, and a short course of corticosteroids, with a rapid rise in platelet number. Am. J. Hematol. 75:139–141, 2004. © 2004 Wiley‐Liss, Inc.
Abstract 361: ZNF24 may modulate microvascular endothelial cell invasion by regulating MMP2 transcription.
Authors: Di Jia, Marsha A. Moses
Journal: Cancer Research (2013)

Abstract ZNF24 is a C2H2 zinc finger transcription factor that regulates angiogenesis by repressing the transcription of vascular endothelial growth factor (VEGF). It has also been implicated in the control of cell proliferation and differentiation in the central nervous system and in hepatocellular carcinoma. In the current study, we have focused on the role of ZNF24 in modulating endothelial cell motility. We have found that silencing of ZNF24 in human microvascular endothelial cells (HMVEC) leads to significantly decreased cell migration and invasion. Consistently, the protein level and proteolytic activity of matrix metalloproteinase-2 (MMP2), but not those of matrix metalloproteinase-9 (MMP9), are significantly downregulated when ZNF24 is silenced in these cells. We have also determined the effect of ZNF24 silencing on the mRNA levels of endogenous inhibitors of MMPs, the tissue inhibitors of metalloproteinases (TIMPs). While TIMP1 and TIMP4 levels are moderately upregulated by ZNF24 silencing, the level of TIMP2, a major regulator of MMP2 proteolytic activity, and that of TIMP3, are significantly decreased. However, ZNF24 siRNA induces only a moderate decrease in the protein level of TIMP2, suggesting that TIMP2 does not play an important role in the regulation of MMP9 activity by ZNF24. Another major regulator of MMP2 proteolytic activity, membrane-type-1 matrix metalloproteinase (MT1-MMP), also does not exhibit significant changes when ZNF24 is silenced, suggesting that MMP2 is regulated by ZNF24 at the transcriptional level. Indeed, the mRNA level of MMP2 is significantly downregulated when cells are transfected with ZNF24 siRNA, indicating that ZNF24 positively regulates the transcription of MMP2. When compared to normal endothelial cells, tumor endothelial cells exhibit higher levels of endogenous ZNF24, suggesting that ZNF24 may function to increase cell invasion in these cells via upregulation of MMP2. Our current studies are focused on determining whether MMP2 is a direct downstream target of ZNF24 as well as on its role(s) in modulating endothelial cell motility in vivo. (Supported by NIH P01 CA045548, the Breast Cancer Research Foundation and the Advanced Medical Research Foundation) Citation Format: Di Jia, Marsha A. Moses. ZNF24 may modulate microvascular endothelial cell invasion by regulating MMP2 transcription. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 361. doi:10.1158/1538-7445.AM2013-361
Complementary therapeutic effects of dual delivery of insulin‐like growth factor‐1 and vascular endothelial growth factor by gelatin microspheres in experimental heart failure
Authors: Antonio Cittadini, Maria Gaia Monti, Valentina Petrillo, Giovanni Esposito, Giorgia Imparato, Alessia Luciani, Francesco Urciuolo, Emanuele Bobbio, Carlo F. Natale, Luigi Saccà, Paolo A. Netti
Journal: European Journal of Heart Failure (2011)
Pulmonary complications in chronic liver disease
Authors: Victor I. Machicao, Maya Balakrishnan, Michael B. Fallon
Journal: Hepatology (2013)

The association of chronic liver disease with respiratory symptoms and hypoxia is well recognized. Over the last century, three pulmonary complications specific to chronic liver disease have been characterized: hepatopulmonary syndrome (HPS), portopulmonary hypertension (POPH), and hepatic hydrothorax (HH). The development of portal hypertension is fundamental in the pathogenesis of each of these disorders. HPS is the most common condition, found in 5%-30% of cirrhosis patients, manifested by abnormal oxygenation due to the development of intrapulmonary vascular dilatations. The presence of HPS increases mortality and impairs quality of life, but is reversible with liver transplantation (LT). POPH is characterized by development of pulmonary arterial hypertension in the setting of portal hypertension, and is present in 5%-10% of cirrhosis patients evaluated for LT. Screening for POPH in cirrhosis patients eligible for LT is critical since severe POPH is a relative contraindication for LT. Patients with moderate POPH, who respond adequately to medical therapy, may benefit from LT, although sufficient controlled data are lacking. HH is a transudative pleural effusion seen in 5%-10% of cirrhosis patients, in the absence of cardiopulmonary disease. Diagnosis of HH should prompt consideration for LT, which is the ultimate treatment for HH. Conservative management includes salt restriction and diuretics, with thoracentesis and transjugular intrahepatic portosystemic shunt (TIPS) as second-line therapeutic options.
Update in Nephrology
Authors: Janis M. Orlowski
Journal: Annals of Internal Medicine (2004)

Updates from the Annual Session20 January 2004Update in NephrologyJanis M. Orlowski, MDJanis M. Orlowski, MDFrom Chicago, Illinois.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-140-2-200401200-00011 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail This account of important, recent clinical advances in nephrology focuses on 3 key topics of interest: hypertension, proteinuria, and renal-replacement therapy. Two single studies—one in the area of nephrolithiasis and the other dealing with glomerulonephritis in the form of lupus-related nephropathy—are also reviewed. The goal was to select studies that provide pathophysiologic insight into a given problem or that are likely to alter clinical practice.NephrolithiasisAlternative Diet Halved the Risk for Recurrent Calcium Oxalate Stones in Hypercalciuric Men Borghi L, Schianchi T, Meschi T, et al. Comparison of two diets for the prevention of recurrent stones in idiopathic hypercalciuria. ...References1. Levy D, Garrison RJ, Savage DD, Kannel WB, Castelli WP. Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study. N Engl J Med. 1990;322:1561-6. [PMID: 2139921] CrossrefMedlineGoogle Scholar2. Wright RS, Reeder GS, Herzog CA, Albright RC, Williams BA, Dvorak DL, et al . Acute myocardial infarction and renal dysfunction: a high-risk combination. Ann Intern Med. 2002;137:563-70. [PMID: 12353943] LinkGoogle Scholar3. Hilgers KF, Mann JF. ACE inhibitors versus AT(1) receptor antagonists in patients with chronic renal disease. J Am Soc Nephrol. 2002;13:1100-8. [PMID: 11912272] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Chicago, Illinois.Contributing Editor: Jennifer Fisher Wilson.Disclosures: None disclosed.Corresponding Author: Janis M. Orlowski, MD, Rush Medical College, 600 South Paulina, Chicago, IL 60612; e-mail, [email protected]edu. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 20 January 2004Volume 140, Issue 2Page: 106-111KeywordsACE inhibitorsBlood pressureCreatinineDietExcretionHypertensionKidneysMedical dialysisMortalityProteinuria ePublished: 20 January 2004 Issue Published: 20 January 2004 CopyrightCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
The Thyroid Gland in Pregnancy
Authors: Irwin M. Freedberg, Milton W. Hamolsky, A. Stone Freedberg
Journal: New England Journal of Medicine (1957)

Abnormal Thyroid Function in PregnancyHypothyroidism and PregnancyA relation between hypothyroidism and sterility has long been suspected and repeatedly investigated. This complex and controversial subject is beyond the specific scope of this review. It is pertinent, however, to note that the prevalence of sterility in hypometabolism has been reported to be 30 to 45 per cent,55 , 56 and thyroid medication (as well as many other therapeutic agents) has been proposed as a treatment of sterility, with successful results claimed in up to 30 per cent of cases.56 , 57 Profound hypothyroidism, however, is not incompatible with full-term normal pregnancy. Town-send,58 in 1897, . . .
Development of Lung Function in Early Life
Authors: Ah-Fong Hoo, Janet Stocks, Sooky Lum, Angie M. Wade, Rosemary A. Castle, Kate L. Costeloe, Carol Dezateux
Journal: American Journal of Respiratory and Critical Care Medicine (2004)

This study aimed to compare lung growth and development during the first year of life in healthy term infants of low or appropriate birth weight for gestation. Paired measurements of forced expiratory volume in 0.4 second, FVC, and forced expiratory flow when 75% of FVC has been exhaled were obtained, using the raised volume technique, at about 7 weeks and 9 months of age in 80 infants (32 low and 48 appropriate birth weight for gestation) of white, nonsmoking mothers. Forced flows and volumes increased with growth. Longitudinal trends in results were compared between the two groups, using random effects modeling and adjusted for potential confounding factors. After adjustment for sex, age, and length, forced expiratory volume was significantly reduced by an average (95% confidence interval) of 9% (2 to 16%) in low birth weight compared with appropriate birth weight for gestation infants throughout the first year of life, with a similar trend in forced expiratory flow (8% [−2 to 17%]) and FVC (4% [−3 to 11%]). These findings suggest that lung function is reduced in low birth weight for gestation infants born to nonsmoking white mothers and that this is independent of somatic growth during infancy.