Effects of Testosterone Replacement on Response to Sildenafil Citrate
Authors: Matthew Spitzer, Shehzad Basaria, Thomas G. Travison, Shalender Bhasin
Journal: Annals of Internal Medicine (2013)

Letters2 April 2013Effects of Testosterone Replacement on Response to Sildenafil CitrateMatthew Spitzer, MD, Shehzad Basaria, MD, Thomas G. Travison, PhD, and Shalender Bhasin, MDMatthew Spitzer, MDFrom Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts.Search for more papers by this author, Shehzad Basaria, MDFrom Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts.Search for more papers by this author, Thomas G. Travison, PhDFrom Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts.Search for more papers by this author, and Shalender Bhasin, MDFrom Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-158-7-201304020-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We agree with Dr. Smoger's comment that testosterone measurements vary because of multiple factors, including assay variation, diurnal and pulsatile secretory rhythms, and variations in sex hormone–binding globulin levels. We measured testosterone between 7:30 and 10:00 a.m. by liquid chromatography–tandem mass spectrometry, which is widely considered the reference method with the highest sensitivity and specificity. However, we concur that additional measurements of testosterone during screening would have been valuable.Obesity is associated with decreased sex hormone–binding globulin, and we agree that it might have played some role in the low levels of total testosterone (1). As such, we ...References1. Bhasin S, Cunningham GR, Hayes FJ, Matsumoto AM, Snyder PJ, Swerdloff RS, et al; Task Force, Endocrine Society. Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2010;95:2536-59. [PMID: 20525905] CrossrefMedlineGoogle Scholar2. Bhasin S, Pencina M, Jasuja GK, Travison TG, Coviello A, Orwoll E, et al. Reference ranges for testosterone in men generated using liquid chromatography tandem mass spectrometry in a community-based sample of healthy nonobese young men in the Framingham Heart Study and applied to three geographically distinct cohorts. J Clin Endocrinol Metab. 2011;96:2430-9. [PMID: 21697255] CrossrefMedlineGoogle Scholar3. Rosen RC, Allen KR, Ni X, Araujo AB. Minimal clinically important differences in the erectile function domain of the International Index of Erectile Function scale. Eur Urol. 2011;60:1010-6. [PMID: 21855209] CrossrefMedlineGoogle Scholar4. Janjic MM, Stojkov NJ, Bjelic MM, Mihajlovic AI, Andric SA, Kostic TS. Transient rise of serum testosterone level after single sildenafil treatment of adult male rats. J Sex Med. 2012;9:2534-43. [PMID: 22429315] CrossrefMedlineGoogle Scholar5. Rosen RC, Cappelleri JC, Gendrano N. The International Index of Erectile Function (IIEF): a state-of-the-science review. Int J Impot Res. 2002;14:226-44. [PMID: 12152111] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M12-0805. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoEffect of Testosterone Replacement on Response to Sildenafil Citrate in Men With Erectile Dysfunction Matthew Spitzer , Shehzad Basaria , Thomas G. Travison , Maithili N. Davda , Amanda Paley , Beth Cohen , Norman A. Mazer , Philip E. Knapp , Samson Hanka , Kishore M. Lakshman , Jagadish Ulloor , Anqi Zhang , Katie Orwoll , Richard Eder , Lauren Collins , Nurahmed Mohammed , Raymond C. Rosen , Leonard DeRogatis , and Shalender Bhasin Effects of Testosterone Replacement on Response to Sildenafil Citrate Steven Smoger Effects of Testosterone Replacement on Response to Sildenafil Citrate Allen D. Seftel and Geoffrey Hackett Effects of Testosterone Replacement on Response to Sildenafil Citrate Antonio Aversa , Emmanuele A. Jannini , Mario Maggi , and Andrea Lenzi Metrics Cited bySexual function of the ageing maleRisks and Benefits of Late Onset Hypogonadism Treatment: An Expert Opinion 2 April 2013Volume 158, Issue 7Page: 570-571KeywordsCellsClinical trialsConflicts of interestDisclosureGlobulinsHuman sexual behaviorObesitySpecificityTestosterone ePublished: 2 April 2013 Issue Published: 2 April 2013 Copyright & PermissionsCopyright © 2013 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...