TOXIC HEPATIC NECROSIS (HEPATITIS) DUE TO ISONIAZID: REPORT OF A CASE WITH CIRRHOSIS AND DEATH DUE TO HEMORRHAGE FROM ESOPHAGEAL VARICES
Authors: A. DONALD MERRITT
Journal: Annals of Internal Medicine (1959)

Case Reports1 March 1959TOXIC HEPATIC NECROSIS (HEPATITIS) DUE TO ISONIAZID: REPORT OF A CASE WITH CIRRHOSIS AND DEATH DUE TO HEMORRHAGE FROM ESOPHAGEAL VARICESA. DONALD MERRITT, M.D., BERNARD F. FETTER, M.D.A. DONALD MERRITT, M.D.Search for more papers by this author, BERNARD F. FETTER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-50-3-804 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough isoniazid is an excellent drug in the therapy of tuberculosis, it does give rise to toxic reactions in some 5% of patients.1The first, more common type of reaction is seen in the nervous system and is manifested by various peripheral neuritides. This toxic effect is apparently related to the pharmacologic action of the drug, and varies in incidence and severity with the dosage.2, 3The second, less common group of reactions is felt to be allergic in nature,4, 6with the varied patterns of dermatitis,1drug fever,4, 7, 8leukopenia, purpura1and hepatitis.6, 9, 10Hepatitis is most...Bibliography1. : The toxicity of isoniazid: a report of the Committee on Therapy, Am. Rev. Tuberc. 68: 302, 1953. MedlineGoogle Scholar2. BiehlVilter JPRW: Effect of isoniazid on vitamin B6 metabolism; its possible significance in producing isoniazid neuritis, Proc. Soc. Exper. Biol. and Med. 85: 389, 1954. CrossrefMedlineGoogle Scholar3. BiehlNimitz JPJ: Studies on the use of a high dose of isoniazid. I. Toxicity studies, Am. Rev. Tuberc. 70: 430, 1954. MedlineGoogle Scholar4. Kalbian V: Isonicotinic acid hydrazide hypersensitivity with pyrexial reaction: report of a case, Tubercle 35: 221, 1954. CrossrefMedlineGoogle Scholar5. MelletteAgress SJH: Toxic reactions to PAS and isoniazid accompanied by leukopenia and atypical lymphocytosis, Am. Rev. Tuberc. 69: 824, 1954. MedlineGoogle Scholar6. BrownGoldsteinChapman HGG: Allergy to isoniazid: successful immunization in two cases, Am. Rev. Tuberc. 74: 683, 1956. MedlineGoogle Scholar7. WalshLynnDerbes JJRHVJ: Pyrexia due to isonicotinic acid hydrazide, J. Allergy 27: 548, 1956. CrossrefMedlineGoogle Scholar8. Krasmitz A: Drug fever due to administration of isoniazid, Am. Rev. Tuberc. 68: 249, 1953. MedlineGoogle Scholar9. RandolphJoseph HS: Toxic hepatitis with jaundice occurring in a patient treated with isoniazid, J. A. M. A. 152: 38, 1953. CrossrefMedlineGoogle Scholar10. GellisMurphy SNRV: Hepatitis following isoniazid, Dis. of Chest 28: 462, 1955. CrossrefMedlineGoogle Scholar11. RothsteinBruce ETH: Management of isoniazid intolerance, J. A. M. A. 155: 745, 1954. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication July 19, 1957.From the Departments of Medicine and Pathology, Duke University School of Medicine, Durham, North Carolina.Requests for reprints should be addressed to A. Donald Merritt, M.D., National Institutes of Health, NIAMD, Room 8N252, Bethesda 14, Maryland. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAcute and Fatal Isoniazid-Induced Hepatotoxicity: A Case Report and Review of the LiteratureSafety of rifampin and pyrazinamide for the treatment of latent tuberculosis infectionHepatotoxicity of antibiotics and antifungalsA review of isoniazid-related hepatotoxicity during chemoprophylaxisToxicidad hepatica grave por drogas antituberculosas. 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BOITNOTT, M.D.Schwerer Arzneimittel-Ikterus durch das Tuberculostaticum Isonicotins�urehydrazid (INH) bei einem Kleinkind mit PhenylketonurieIsoniazid jaundice during the treatment of genitourinary tuberculosisInterpretation of the Liver BiopsyTHE HISTOPATHOLOGY OF DRUG-INDUCED LIVER DISEASEEFFECTS OF SOME ANTIMICROBIAL AGENTS ON THE LIVER*Isoniazid jaundice and its relationship to iproniazid jaundiceCase 42-1961DRUG-INDUCED HEPATIC INJURY*HANS POPPER, M.D., F.A.C.P., FENTON SCHAFFNER, M.D., F.A.C.P. 1 March 1959Volume 50, Issue 3Page: 804-810KeywordsAllergy and immunologyDrug therapyDrugsHemorrhageHepatitisHepatitis AIsoniazidNecrosisNervous systemOsteomyelitis Issue Published: 1 March 1959 PDF downloadLoading ...