tbuckley/cabot-search huggingface dataset:
PTU-153 A Formal Surveillance Program with Dedicated Endoscopy Lists is Required to Improve Compliance with the British Society of Gastroenterology (BSG) Guidelines for Diagnosis and Management of Barrett’S Columnar-Lined Oesophagus
Authors: K Nemeth, V Shah, A Rasheed
Journal: Gut (2013)

<h3>Introduction</h3> Endoscopic surveillance of Barrett’s oesophagus is recommended by many national societies to detect progression to adenocarcinoma at an earlier stage. Our aim was to audit Aneurin Bevan Health Board (ABHB) compliance with the 2005 British Society of Gastroenterology (BSG) guidelines for the diagnosis and management of Barrett’s columnar-lined oesophagus. <h3>Methods</h3> Aneurin Bevan Health Board electronic prospective histopathological database was searched to identify all cases coded as Barrett’s oesophagus (BO) during the period from 2005 to 2011. Endoscopy reports of all patients were matched with histology reports. A retrospective registry was then constructed including demographics, clinico-pathological features, modes and rates of follow-up, pathological progression and incident cancer rate during the study period. <h3>Results</h3> A total of 773 cases were coded as BO during the period 2005 to 2011. Interrogation of all records confirmed 620 cases to be worthy of inclusion excluding 153 cases due to inadequate data or incorrect coding. The 620 cohort of patients consisted of 406 males and 214 females with a median age of 65 years (range 20 to 97years). BO histological confirmation was attained in 592/620 cases at index endoscopy and during a follow-up endoscopy in 28/620 cases. Intestinal metaplasia was reported in 459/620 cases. Dysplasia was diagnosed in 58/620 cases at index endoscopy; 16/620 of these index cases were reported as indefinite for dysplasia, 32/620 were low grade dysplasia and 10/620 cases were classified as high grade dysplasia. 233/620 (37.6%) patients had on average one follow-up and 100/620 (16.1%) had two or more follow ups during the study period. <h3>Conclusion</h3> Compliance with BSG follow-up recommendations and other practise parameters is poor. We recommend a formal surveillance programme with dedicated endoscopy lists to improve compliance and permit a meaningful assessment of the clinical and cost effectiveness of such strategy. <h3>Disclosure of Interest</h3> None Declared
A Study of Serum Antibody Activity in Workers with Occupational Exposure to Diphenylmethane Diisocyanate
Authors: K. S. Tse, A. Johnson, H. Chan, M. Chan‐Yeung
Journal: Allergy (1985)

The prevalence of sensitization was studied in a group of 76 foundry workers with occupational exposure to diphenylmethane diisocyanate (MDI). Ten workers had clinical evidence of asthma, 40 had non‐asthmatic respiratory symptoms, and 26 were asymptomatic. Specific IgE antibodies to MDI were found in two workers (2.6%) and specific IgG antibodies, in five workers (6.6%). The prevalence of IgE and IgG antibodies was higher in the 10 subjects with asthma than in the non‐asthmatic group. The prevalence of anti‐paratolyl‐monoisocyanate antibodies was not significantly different from that of anti‐MDI antibodies, and both haptenic determinants displayed a high degree of cross‐reactivity in the RAST inhibition test. The role of humoral immunological mechanisms in MDI‐induced asthma is unclear in view of the rather low prevalence of these serum antibodies in this group of workers.
Tc-99m Pyrophosphate Localization in Chest Wall Muscles After Bench Pressing
Authors: MICHAEL R. WILLIAMSON, FRANK ARCHIBEQUE, BRIAN EISENBERG, SUSAN WILLIAMSON, ROBERT ROSENBERG
Journal: Clinical Nuclear Medicine (1989)

A 39–year–old man had right-sided chest pain that was atypical for a cardiac etiology. A previous exercise thallium test had been suggestive of anterolateral Ischemia. An infarct Image using Tc–99m PYP was performed. There was diffuse uptake in the distribution of the pectoralis major muscles. Palpation of the right upper chest reproduced the patient's pain. Further history revealed that the patient has finished a workout at a spa three hours previously. Excessive muscle exertion is a recognized cause of localization of bone–imaging radionuclides in muscle. In performing the bench press, some weight lifters bounce the bar off the chest, and this can lead to chest wall soreness and potentially could cause muscle trauma. This is an alternate explanation for the increased uptake.
Personalized Medicine in the Era of Genomics
Authors: Wylie Burke, Bruce M. Psaty
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Life class lives again
Authors: H V Wyatt
Journal: BMJ (2007)

The teachers at Homerton School of Art were worried that their students could draw still life, but not movement. They made a film with five nude models, always on the move, while the students made drawings on paper arranged on the floor. As a visiting lecturer at Bradford College of Art, I was invited to see the film, and my thoughts turned to my own students—making one or two drawings in a two hour practical …
The Use of Sodium Malate Combinations as a Dietary Substitute for Sodium Chloride.
Authors: JOHN C. KRANTZ
Journal: Annals of Internal Medicine (1930)

Article1 February 1930The Use of Sodium Malate Combinations as a Dietary Substitute for Sodium Chloride.JOHN C. KRANTZ JR., Ph.D.JOHN C. KRANTZ JR., Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-3-8-826 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIntroduction: The prevalence of the prescribing of the diet of salt restriction for patients suffering with chronic interstitial nephritis, edema or hypertension is emphasized by Allen1who estimates this number to be more than two million in the United States. Although the most enthusiastic advocates of the diet of salt restriction claim beneficial results in cases of nephritis, edema and hypertension, little evidence is available in the literature indicating work upon the production of sodium chloride substitutes to increase the palatability of the salt restricted diet. In 1912 Javal2suggested the use of sodium bromide or iodide to improve the...Bibliography1 ALLEN FM: New York State Med. J. (1925), 25, 728. Google Scholar2 JAVAL MA: Zentr. Bioch. Hioph., (1912), 14, 526. Google Scholar2a Tuteur-Klin. Wochenschrift No. 37 (1918) 2467. Google Scholar3 ROSE WC: J. Pharm. Exp. Therap., (1925), 25, 59. Google Scholar4 UNDERHILL : J. Exper. Med., (1913), 18, 322 and 347. ROSE, W. C.: J. Pharm. Exp. Therap., (1925), 24, 123. CrossrefMedlineGoogle Scholar5 SALANTWISE WLS: Journ. Biol. Chem., (1916), 28, 27. CrossrefGoogle Scholar6 DOWNS CR: U. S. Patent 1,374,720, Chem. Abs., (1921), 15, 2641. Google Scholar7 OHTA K: Biochem. Z., (1912), 44, 482. Google Scholar8 WISE LE: Journ. Biol. Chem., (1916), 28, 185. CrossrefGoogle Scholar9 UNDERHILLPACK : J. Pharm. and Exp. Therap., (1925), 25, 467. Google Scholar10 ROSE EC: J. Pharm. and Exp. Therap., (1925), 24, 123. Google Scholar11 BARGERO : Biol. Chem. Centr., (1906), 5, 504. Google Scholar12 RINGERFRANKELJONES : J. Biol. Chem., (1913), 14, 539. CrossrefGoogle Scholar13 MULLIKEN : Identification of Pure Organic Compounds, p. 83, Wiley & Sons. Google Scholar14 UNDERHILLWAKEMAN : J. Biol. Chem., (1922), 54, 701. CrossrefGoogle Scholar15 WILSON : J. Ind. and Eng. Chem., (1925), 17, 74. CrossrefGoogle Scholar46 FISCHER MH: Am. Med. Assn., (1914), 60, 1682. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOHN C. KRANTZJR., Ph.D.Affiliations: Baltimore, Md. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Effect of Sodium Malate Combinations Upon Gastric AcidityJOHN C. KRANTZ JR., Ph.D., A. A. SILVER, M.D., BERNARD J. HOFFMAN 1 February 1930Volume 3, Issue 8Page: 826-834KeywordsDietEdemaHypertensionNephritisSaltsSodiumSodium chloride ePublished: 1 December 2008 Issue Published: 1 February 1930 PDF downloadLoading ...
Comment: Controlled Clinical Trials
Authors: Philip Rubin
Journal: JAMA (1967)

No better demonstration of the directions and dilemmas in reporting cancer results after different forms of therapy can be illustrated than in the statements in this and subsequent articles on breast cancer. The issue of controlled clinical trials and their value and future role in advancing medical knowledge must be surfaced by each physician. Inherent in all decisions to apply cancer therapy is the<i>choice</i>between different modalities: surgery and/or radiotherapy and/ or chemotherapy. Too often, the choice rests on personal prejudices referred to as "fundamental principles" and "my clinical experience" which is small, sporadic, anecdotal, and inadequately analyzed. The alternative to controlled clinical trials is uncontrolled, haphazard clinical experiences. Into which category do you fall and will you continue to fall? The reports of the present contributors as to the value of their surgical results are beclouded by the use of postoperative irradiation. Crile states that 44% of all
Morbidity and Mortality in the Wolfram Syndrome
Authors: Brendan T Kinsley, Michael Swift, Raymonde H Dumont, Ronnie G Swift
Journal: Diabetes Care (1995)

OBJECTIVE To determine the major causes of morbidity and mortality in the autosomal recessive Wolfram syndrome, which is defined by diabetes and bilateral progressive optic atrophy with onset in childhood or adolescence. RESEARCH DESIGN AND METHODS We abstracted and reviewed the medical records of 68 confirmed cases of Wolfram syndrome identified through a nationwide survey of endocrinologists, ophthalmologists, institutes, and homes for the blind. We also reviewed all available autopsy records. RESULTS The most common causes of morbidity and mortality were the neurological manifestations of this syndrome and the complications of urinary tract atony. There was a lower frequency of diabetic ketoacidosis, no histologically proven diabetic glomerulosclerosis, and less severe, more slowly progressive, diabetic retinopathy than in classic type I diabetic patients. Mortality in Wolfram syndrome is much higher than in type I diabetes; 60% of Wolfram syndrome patients die by age 35. Recognition of these clinical differences from classic type I diabetes is important for the proper management of Wolfram syndrome patients. CONCLUSIONS Identification of Wolfram syndrome patients among all diabetic patients presenting in childhood or adolescence is important because the management of patients with this syndrome is different from that of patients with classic type I diabetes.
Alexithymic Asthmatics: Age and Alexithymia across the Life Span
Authors: Robert J. Feiguine, Deborah M. Hulihan, Robert A. Kinsman
Journal: Psychotherapy and Psychosomatics (1982)

The relationship between age and alexithymia was evaluated within a large (n = 476) group of asthmatic patients ranging in age from 14 to 76 years. Alexithymia was found to occur more frequently in the upper age ranges (middle and late adulthood) than in adolescence and early adulthood. Hypotheses regarding this relationship are addressed.
Genome Sequencing of SHH Medulloblastoma Predicts Genotype-Related Response to Smoothened Inhibition
Authors: Marcel Kool, David T.W. Jones, Natalie Jäger, Paul A. Northcott, Trevor J. Pugh, Volker Hovestadt, Rosario M. Piro, L. Adriana Esparza, Shirley L. Markant, Marc Remke, Till Milde, Franck Bourdeaut, Marina Ryzhova, Dominik Sturm, Elke Pfaff, Sebastian Stark, Sonja Hutter, Huriye Şeker-Cin, Pascal Johann, Sebastian Bender, Christin Schmidt, Tobias Rausch, David Shih, Jüri Reimand, Laura Sieber, Andrea Wittmann, Linda Linke, Hendrik Witt, Ursula D. Weber, Marc Zapatka, Rainer König, Rameen Beroukhim, Guillaume Bergthold, Peter van Sluis, Richard Volckmann, Jan Koster, Rogier Versteeg, Sabine Schmidt, Stephan Wolf, Chris Lawerenz, Cynthia C. Bartholomae, Christof von Kalle, Andreas Unterberg, Christel Herold-Mende, Silvia Hofer, Andreas E. Kulozik, Andreas von Deimling, Wolfram Scheurlen, Jörg Felsberg, Guido Reifenberger, Martin Hasselblatt, John R. Crawford, Gerald A. Grant, Nada Jabado, Arie Perry, Cynthia Cowdrey, Sydney Croul, Gelareh Zadeh, Jan O. Korbel, Francois Doz, Olivier Delattre, Gary D. Bader, Martin G. McCabe, V. Peter Collins, Mark W. Kieran, Yoon-Jae Cho, Scott L. Pomeroy, Olaf Witt, Benedikt Brors, Michael D. Taylor, Ulrich Schüller, Andrey Korshunov, Roland Eils, Robert J. Wechsler-Reya, Peter Lichter, Stefan M. Pfister
Journal: Cancer Cell (2014)
The Neurosciences: Paths of Discovery
Authors: Lawrence C. McHenry
Journal: JAMA (1976)

This weighty paperback commemorates the 70th birthday of Francis O. Schmitt. The symposium was organized around "the theme of discovery in neuroscience that... in its demonstration of interdisciplinary interaction" would support the emphasis of Schmitt's career. It focuses on the way scientific discovery and understanding came about through the interaction of individuals with each other, with ideas, with technological developments, and above all else, with those social and organizational influences that created a shared experience in the neuroscience community. The symposium presents the major work in neuroscience over the past 40 years. After an introductory chapter, John Z. Young gives a pithy and inquiring analysis of the aims and methods of neuroscience. Papers by Kennedy, Edelman, and Weiss discuss the many different kinds of nervous systems that have emerged during evolutionary development. Szentágothi and Brodal leave one with the notion that there is a need to reassess the modern neuron
Safety and immunogenicity of a novel recombinant adenovirus type-5 vector-based Ebola vaccine in healthy adults in China: preliminary report of a randomised, double-blind, placebo-controlled, phase 1 trial
Authors: Feng-Cai Zhu, Li-Hua Hou, Jing-Xin Li, Shi-Po Wu, Pei Liu, Gui-Rong Zhang, Yue-Mei Hu, Fan-Yue Meng, Jun-Jie Xu, Rong Tang, Jin-Long Zhang, Wen-Juan Wang, Lei Duan, Kai Chu, Qi Liang, Jia-Lei Hu, Li Luo, Tao Zhu, Jun-Zhi Wang, Wei Chen
Journal: The Lancet (2015)
[510] COMBINATION OF HBV-ACTIVE ANTIRETROVIRAL THERAPY INFLUENCES HBV VIROLOGICAL SUPPRESSION IN AN INTERNATIONAL COHORT OF 120 HIVHBV COINFECTED INDIVIDUALS
Authors: G.Y. Matthews, E. Seaberg, G.J. Dore, S.R. Lewin, S. Bowden, J. Sasadeuz, P. Marks, J. Hoy, S. Locarnini, C.L. Thio
Journal: Journal of Hepatology (2007)
Association of Waking Episodes With Menopausal Hot Flushes
Authors: Yohanan Erlik
Journal: JAMA (1981)

To examine the possible relationship between the occurrence of menopausal hot flushes and waking episodes, a study was conducted of nine postmenopausal women with severe hot flushes and five asymptomatic premenopausal women. Measurement of simultaneous changes of finger temperature and skin resistance over the sternum was used as an objective marker of hot flushes. During cumulative sleep 47 objectively measured hot flushes occurred, and 45 were associated with a waking episode measured by polygraphic techniques. In eight of nine subjects, a significant correlation was observed between the occurrence of hot flushes and waking episodes. A similar association was not observed in premenopausal subjects. Estrogen administered to symptomatic patients resulted in significant reductions of both hot flushes and waking episodes. These data suggest that menopausal flushes are associated with a chronic sleep disturbance, and both can be improved by estrogen therapy. (<i>JAMA</i>1981;245:1741-1744)
Growth arrest and DNA damage‐inducible 34 regulates liver regeneration in hepatic steatosis in mice
Authors: Yuka Inaba, Tomoko Furutani, Kumi Kimura, Hitoshi Watanabe, Sanae Haga, Yoshiaki Kido, Michihiro Matsumoto, Yasuhiko Yamamoto, Kenichi Harada, Shuichi Kaneko, Seiichi Oyadomari, Michitaka Ozaki, Masato Kasuga, Hiroshi Inoue
Journal: Hepatology (2014)

The liver has robust regenerative potential in response to damage, but hepatic steatosis (HS) weakens this potential. We found that the enhanced integrated stress response (ISR) mediated by phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (eIF2α) impairs regeneration in HS and that growth arrest and DNA damage-inducible 34 (Gadd34)-dependent suppression of ISR plays a crucial role in fatty liver regeneration. Although mice fed a high-fat diet for 2 weeks developed moderate fatty liver with no increase in eIF2α phosphorylation before 70% hepatectomy, they showed impaired liver regeneration as a result of reduced proliferation and increased death of hepatocytes with increased phosphorylation of eIF2α and ISR. An increased ISR through Gadd34 knockdown induced C/EBP homologous protein (CHOP)-dependent apoptosis and receptor-interacting protein kinase 3-dependent necrosis, resulting in increased hepatocyte death during fatty liver regeneration. Furthermore, Gadd34 knockdown and increased phosphorylation of eIF2α decreased cyclin D1 protein and reduced hepatocyte proliferation. In contrast, enhancement of Gadd34 suppressed phosphorylation of eIF2α and reduced CHOP expression and hepatocyte apoptosis without affecting hepatocyte proliferation, clearly improving fatty liver regeneration. In more severe fatty liver of leptin receptor-deficient db/db mice, forced expression of hepatic Gadd34 also promoted hepatic regeneration after hepatectomy.Gadd34-mediated regulation of ISR acts as a physiological defense mechanism against impaired liver regeneration resulting from steatosis and is thus a possible therapeutic target for impaired regeneration in HS.
Current status of surgery in dermatology
Authors: C. William Hanke, Ronald L. Moy, Randall K. Roenigk, Henry H. Roenigk, James M. Spencer, Emily P. Tierney, Cynthia L. Bartus, Robert M. Bernstein, Marc D. Brown, Mariano Busso, Alastair Carruthers, Jean Carruthers, Omar A. Ibrahimi, Arielle N.B. Kauvar, Kathryn M. Kent, Nils Krueger, Marina Landau, Aimee L. Leonard, Stephen H. Mandy, Thomas E. Rohrer, Neil S. Sadick, Luitgard G. Wiest
Journal: Journal of the American Academy of Dermatology (2013)
Respiratory Allergy in Patients with Cystic Fibrosis
Authors: L. L. Kulczycki
Journal: JAMA (1961)

In this study of 266 living patients with cystic fibrosis, ranging in age from 1 1/2 to 35 years, respiratory allergy was documented in 44 patients, or 16.6 per cent. Although a number of patients had been treated for respiratory allergy prior to the diagnosis of cystic fibrosis, more than half of those patients did not meet the requirements for a diagnosis of allergy. This study included detailed histories, skin tests, sweat tests, x-rays, and repeated clinical evaluation. The sweat-electrolyte level was markedly elevated in patients with cystic fibrosis and was well within the normal range in patients with respiratory allergy alone. It is suggested that cystic fibrosis be considered in the differential diagnosis when dealing with recurrent respiratory tract involvement in patients at all ages; one should be aware of the possible coexistence of allergy in patients with cystic fibrosis.
The Role of Polyneuropathy in Motor Convalescence After Prolonged Mechanical Ventilation
Authors: Frans S. S. Leijten
Journal: JAMA (1995)

To test the hypothesis that prolonged motor recovery after long-term ventilation may be due to polyneuropathy and can be foreseen at an early stage by electromyography (EMG).Cohort study with an entry period of 18 months. Polyneuropathy was identified by EMG studies in the intensive care unit (ICU). During a 1-year follow-up, amount of time was recorded to reach a rehabilitation end point.The general ICU of a community hospital.Fifty patients younger than 75 years who were receiving mechanical ventilation for more than 7 days.A rehabilitation end point was defined as return of normal muscle strength and ability to walk 50 m independently.In 29 of 50 patients, an EMG diagnosis of polyneuropathy was made in the ICU. Patients with polyneuropathy had a higher mortality in the ICU (14 vs 4; P = .03), probably related to multiple organ failure (22 vs 11; P = .08) or aminoglycoside treatment of suspected gram-negative sepsis (17 vs 4; P = .05). Rehabilitation was more prolonged in 12 patients with polyneuropathy than in 12 without polyneuropathy (P = .001). Of nine patients with delays beyond 4 weeks, eight had polyneuropathy, five of whom had persistent motor handicap after 1 year. In particular, axonal polyneuropathy with conduction slowing on EMG indicated a poor prognosis.Polyneuropathy in the critically ill is related to multiple organ failure and gram-negative sepsis, is associated with higher mortality, and causes important rehabilitation problems. EMG recordings in the ICU can identify patients at risk.
Individual and Group Training Program
Authors: Manuel Ruiz Ruiz, Antonio Porras Torres, Federico Martin Ortiz, Eduardo Sanchez Guerrero, Salvador Crossa Ramirez
Journal: Psychotherapy and Psychosomatics (1990)

We describe the experience of a didactic analysis group during a 3-year period in the Academy of Analytical Psychotherapy placing special emphasis on the training of the psychoanalyst, who, apart from carrying out his individual analysis, must complement it with group training. The advantages of the group analysis are given particular attention when evaluating the training of the candidate from the point of view of the psychoanalyst and the 6 doctors who have received this education. In this type of training for individuals and groups the program aims at a deeper study of the aspects of narcissism, the formation of the self and the social ego which we consider to be the fundamental elements in the development of this didactic experience.
764-5 Microvascular Integrity Preserves Contractile Reserve in Post-Infarction Dysfunctioning Myocardium
Authors: Venanzio F. Napoli, Cataldo Memmola, Leonarda Galiuto, Alfredo Marchese, Paolo Colonna, Vito Marangelli, Sabino Iliceto, Paolo Rizzon
Journal: Journal of the American College of Cardiology (1995)