tbuckley/cabot-search huggingface dataset:
Are rheumatoid nodules caused by vasculitis? A study of 13 early cases.
Authors: J J Rasker, F C Kuipers
Journal: Annals of the Rheumatic Diseases (1983)

Rheumatoid nodules are especially found in patients with seropositive rheumatoid arthritis (RA). It is often suggested that the genesis of these lesions is due to a vasculitis in smaller capillary vessels or venules. To test this hypothesis we studied fresh nodules in 13 patients, all with classical or definite RA. In 7 cases a total of 8 nodules were removed within 10 days of origin and in 6 other cases between 2 and 8 weeks. In the former group immunofluorescence was found in 5 out of 8 cases, and in the latter group 3 out of 6 were positive. Immunoglobulin deposition together with complement was found only in cases of 10 days' duration or less. No correlation was found with the patient's age or disease duration, ESR, ANA positivity, Rose titre, haemoglobulin, or use of prednisolone. In 3 out of 7 nodules younger than 7 days no palisade layer was found, whereas in older nodules this layer was always present. Vasculitis was not more frequently present in the cases with younger nodules. Our study does not support the hypothesis that vasculitis is the primary cause of nodules.
Trade agreement could lock NHS into competitive market, campaign groups say
Authors: P. Davies
Journal: BMJ (2013)

European and US health campaigning groups have raised concerns with the US president and European Union leaders about the implications of a forthcoming free trade agreement between the EU and the United States, negotiations for which began in Washington, DC, on 8 July. 

They fear that the Transatlantic Trade and Investment Partnership (TTIP) may damage public services in favour of commercial interests. 

Meanwhile, leaked documents from the EU seem to confirm that opening state owned enterprises to competition is a priority for negotiators.

Sixty three campaigning organisations, trade unions, and consumer groups wrote to Barack Obama, European Commission president Jose Manuel Barroso, and European Council president Herman Van Rompuy on 8 July, denouncing the …
The Health Care of Hispanics
Authors: Rodolfo D. Eichberg
Journal: JAMA (1991)

<h3>To the Editor.—</h3> The January 9, 1991, issue of<i>JAMA</i>contains several articles relating to health care among "Hispanics." I would like the authors to define what they mean by Hispanics. "Hispanic" is neither a race nor a definite group of people. The word<i>Hispanic</i>presumably refers to Spain, although the articles deal with Latin American immigrants. I have a very difficult time understanding who a Hispanic is supposed to be and why these people are grouped together. I see no similarity whatsoever from the racial, biological, cultural, or linguistic point of view among these populations. I am well aware of the fact that<i>Hispanic</i>is a word found in many application forms, statistical analyses, etc, but I was never able to understand what this means. I would like to ask the authors of these articles to explain the similarities between an Argentinian of Italian descent, a Bolivian of Indian
Laparoscopy in Fever of Unknown Origin - Study of Seventy Cases
Authors: J.A. Solis-Herruzo, V. Benita, J.D. Morillas
Journal: Endoscopy (1981)

Laparoscopy was performed on 70 patients with FUO after clinical review and when bacteriological, serological and radiological investigations had failed to reveal the diagnosis. Laparoscopy proved helpful in making the diagnosis in 68.4% of these patients; in 44.2% it provided a definite diagnosis, and in 24.2% it contributed significantly to the establishment of a diagnosis. Laparoscopy was of most use (76.6%) in those patients with physical signs or biochemical results suggestive of an abdominal disorder. In the absence of such sign laparoscopy was helpful in only 20.0% of patients. There was no mortality, and morbidity was insignificant. It is our conclusion that laparoscopy can be recommended in FUO, particularly in patients with signs of abdominal disease.
A CONTRIBUTION TO THE SUBJECT OF RADIOTHERAPY AND PHOTOTHERAPY IN CARCINOMA, TUBERCULOSIS AND OTHER DISEASES OF THE SKIN.
Authors: JAMES NEVINS HYDE
Journal: JAMA (1903)

Since 1894, when Finsen published his first paper on the value of the actinic rays in variola, and the year 1895, when Roentgen presented his historical paper to the Physico-Medical Society of Wurzburg, the literature of the general subject of radiotherapy and photo-therapy has accumulated in geometric proportions. It is not the purpose of the present paper to survey this literature, but merely to present the results of our personal observations and experience in the management of cutaneous diseases by the modern method of light treatment. It is worthy of note, however, that while the present therapeutic use of the<i>x</i>-rays was first suggested as a result of accidents occurring in its use for diagnostic and other purposes, the light-treatment of Finsen and his followers is largely the direct and logical outcome of the work of earlier observers, who studied the influence of light in its various forms on certain
Oncostatin M promotes mucosal epithelial barrier dysfunction, and its expression is increased in patients with eosinophilic mucosal disease
Authors: Kathryn L. Pothoven, James E. Norton, Kathryn E. Hulse, Lydia A. Suh, Roderick G. Carter, Erin Rocci, Kathleen E. Harris, Stephanie Shintani-Smith, David B. Conley, Rakesh K. Chandra, Mark C. Liu, Atsushi Kato, Nirmala Gonsalves, Leslie C. Grammer, Anju T. Peters, Robert C. Kern, Paul J. Bryce, Bruce K. Tan, Robert P. Schleimer
Journal: Journal of Allergy and Clinical Immunology (2015)
Derivation of Stable Microarray Cancer-Differentiating Signatures Using Consensus Scoring of Multiple Random Sampling and Gene-Ranking Consistency Evaluation
Authors: Zhi Qun Tang, Lian Yi Han, Hong Huang Lin, Juan Cui, Jia Jia, Boon Chuan Low, Bao Wen Li, Yu Zong Chen
Journal: Cancer Research (2007)

Abstract Microarrays have been explored for deriving molecular signatures to determine disease outcomes, mechanisms, targets, and treatment strategies. Although exhibiting good predictive performance, some derived signatures are unstable due to noises arising from measurement variability and biological differences. Improvements in measurement, annotation, and signature selection methods have been proposed. We explored a new signature selection method that incorporates consensus scoring of multiple random sampling and multistep evaluation of gene-ranking consistency for maximally avoiding erroneous elimination of predictor genes. This method was tested by using a well-studied 62-sample colon cancer data set and two other cancer data sets (86-sample lung adenocarcinoma and 60-sample hepatocellular carcinoma). For the colon cancer data set, the derived signatures of 20 sampling sets, composed of 10,000 training test sets, are fairly stable with 80% of top 50 and 69% to 93% of all predictor genes shared by all 20 signatures. These shared predictor genes include 48 cancer-related and 16 cancer-implicated genes, as well as 50% of the previously derived predictor genes. The derived signatures outperform all previously derived signatures in predicting colon cancer outcomes from an independent data set collected from the Stanford Microarray Database. Our method showed similar performance for the other two data sets, suggesting its usefulness in deriving stable signatures for biomarker and target discovery. [Cancer Res 2007;67(20):9996–10003]
Regulation of energy substrate metabolism in the diabetic heart
Authors: W Stanley
Journal: Cardiovascular Research (1997)

The effects of diabetes on myocardial metabolism are complex in that they are tied to the systemic metabolic abnormalities of the disease (hyperglycemia and elevated levels of free fatty acid and ketone bodies), and changes in cardiomyocyte phenotype (e.g., down-regulation of glucose transporters and PDH activity). The cardiac adaptations appear to be driven by the severity of the systemic abnormalities of the disease. The diabetes-induced changes in the plasma milieu and cardiac phenotype both cause impaired glycolysis, pyruvate oxidation, and lactate uptake, and a greater dependency on fatty acids as a source of acetyl CoA. Studies in isolated hearts suggest that therapies aimed at decreasing fatty acid oxidation, or directly stimulating pyruvate oxidation would be of benefit to the diabetic heart during and following myocardial ischemia.
Authors' reply to Kremer and Van de Perre
Authors: N. J. Beeching, M. Fenech, C. F. Houlihan
Journal: BMJ (2015)

<h3>Abstract</h3> The rapid emergence of coronavirus disease 2019 (COVID-19) as a global pandemic affecting millions of individuals globally has necessitated sensitive and high-throughput approaches for the diagnosis, surveillance and for determining the genetic epidemiology of SARS-CoV-2. In the present study, we used the COVIDSeq protocol, which involves multiplex-PCR, barcoding and sequencing of samples for high-throughput detection and deciphering the genetic epidemiology of SARS-CoV-2. We used the approach on 752 clinical samples in duplicates, amounting to a total of 1536 samples which could be sequenced on a single S4 sequencing flow cell on NovaSeq 6000. Our analysis suggests a high concordance between technical duplicates and a high concordance of detection of SARS-CoV-2 between the COVIDSeq as well as RT-PCR approaches. An in-depth analysis revealed a total of six samples in which COVIDSeq detected SARS-CoV-2 in high confidence which were negative in RT-PCR. Additionally, the assay could detect SARS-CoV-2 in 21 samples and 16 samples which were classified inconclusive and pan-sarbeco positive respectively suggesting that COVIDSeq could be used as a confirmatory test. The sequencing approach also enabled insights into the evolution and genetic epidemiology of the SARS-CoV-2 samples. The samples were classified into a total of 3 clades. This study reports two lineages B.1.112 and B.1.99 for the first time in India. This study also revealed 1,143 unique single nucleotide variants and added a total of 73 novel variants identified for the first time. To the best of our knowledge, this is the first report of the COVIDSeq approach for detection and genetic epidemiology of SARS-CoV-2. Our analysis suggests that COVIDSeq could be a potential high sensitivity assay for detection of SARS-CoV-2, with an additional advantage of enabling genetic epidemiology of SARS-CoV-2.
Treatment of Hemoptysis.
Authors: Francis Hare
Journal: JAMA (1905)

London, Jan. 21, 1905. <h3>To the Editor:</h3> —In an article entitled "The Control of Internal Hemorrhage by Drugs," Dr. Thomas Luther Coley says: "This group (nitroglycerin and the nitrites) has been recommended for pulmonary hemorrhage. It would seem, however, that the general widening of the blood paths, together with the fact that the heart beats more rapidly under the lowered pressure, would contraindicate its employment. The general widening of the blood paths will frequently increase the caliber of the vessels of the bleeding area." It is a question whether an increase in the caliber of the vessels of a bleeding area is of any importance in circumstances which provide for a fall of blood-pressure in that area. This, however, applies to hemorrhage from the systemic, not from the pulmonary, circulation. In the latter, it is highly improbable that an increase of caliber ever occurs through the action of the nitrites;
Oxidative damage is increased in human liver tissue adjacent to hepatocellular carcinoma
Authors: Christoph Jüngst, Bin Cheng, Ralph Gehrke, Volker Schmitz, Hans Dieter Nischalke, Jan Ramakers, Peter Schramel, Peter Schirmacher, Tilman Sauerbruch, Wolfgang Helmut Caselmann
Journal: Hepatology (2004)

Accumulation of genetic alterations in hepatocarcinogenesis is closely associated with chronic inflammatory liver disease. 8-oxo-2′-deoxyguanosine (8-oxo-dG), the major promutagenic DNA adduct caused by reactive oxygen species (ROS), leads to G:C → T:A transversions. These lesions can be enzymatically repaired mainly by human MutT homolog 1 (hMTH1), human 8-oxo-guanine DNA glycosylase (hOGG1) and human MutY homolog (hMYH). The aim of this study was to evaluate the extent of oxidative damage and its dependence on the cellular antioxidative capacity and the expression of specific DNA repair enzymes in tumor (tu) and corresponding adjacent nontumor (ntu) liver tissue of 23 patients with histologically confirmed hepatocellular carcinoma. 8-oxo-dG levels, as detected by high-pressure liquid chromatography with electrochemical detection, were significantly ( P = .003) elevated in ntu tissue (median, 129 fmol/μg DNA) as compared to tu tissue (median, 52 fmol/μg DNA), and were closely associated with inflammatory infiltration. In ntu tissue, the hepatic iron concentration and malondialdehyde levels were significantly ( P = .001) higher as compared to tu tissue. Glutathione content, glutathione peroxidase activity and manganese superoxide dismutase messenger RNA (mRNA) expression did not show statistical differences between ntu and tu tissue. Real-time reverse transcription polymerase chain reaction revealed in tu tissue significantly ( P = .014) higher hMTH1 mRNA expression compared to ntu tissue. In contrast, hMYH mRNA expression was significantly ( P &lt; .05) higher in ntu tissue. No difference in hOGG1 mRNA expression was seen between tu and ntu. In conclusion , these data suggest that ROS generated by chronic inflammation contribute to human hepatocarcinogenesis. The role of DNA repair enzymes appears to be of reactive rather than causative manner. (Hepatology 2004;39:1663-1672.)
Identification of ultimate DNA damaging oxygen species.
Authors: B Epe, J Hegler, D Wild
Journal: Environmental Health Perspectives (1990)

DNA damage induced by various reactive oxygen species can be characterized using a set of repair endonucleases with defined substrate specificities. DNA damage profiles thus obtained in a cell-free system can be compared with those observed in cellular DNA. Using this approach, we have demonstrated that an illumination of Salmonella typhimurium cells with visible light in the presence of methylene blue gives rise to a DNA damage profile very similar to that of singlet oxygen in a cell-free system. Therefore, the genotoxicity observed under these conditions most probably is attributable to the direct action of this species. The damage consists mainly of base modifications that are subject to repair by uvrABC-independent pathways. Revertant frequencies observed in parallel in the strains TA100 and TA2638 indicate a pronounced mutagenicity of the lesions induced. Exposure of Salmonella typhimurium to tert-butylhydroperoxide gives rise to another form of damage profile that is also different from that produced by hydroxyl radicals in a cell-free system. However, the latter dissimilarity does not exclude hydroxyl radicals as ultimate reactive species, as a very rapid repair of the induced base modifications is observed, which might have distorted the damage profile despite immediate work up.
Effects of electroconvulsive therapy on serum myelin basic protein immunoreactivity.
Authors: M Philpot
Journal: BMJ (1984)

perform a similar study of patients with Crohn's disease.Twenty two consecutive patients with Crohn's disease (11 men, 11 women, mean age 42, range 19-83) attending an outpatient clinic were studied.The Crohn's disease had been present from one month to 22 years (mean 61 years), and a disease activity index' at the time of study was 0-15 (mean 4).A random urine sample was collected, and urinary cc, microglobulin concentration measured by single radial immunodiffusion with the results corrected for urinary creatinine concentration and expressed as mg/g creatinine.Albustix testing was negative, and plasma creatinine concentrations were normal in all patients.Urine cx, microglobulin concentration was increased in 10 patients (> 10 mg/g creatinine) (mean (SD) 37 6 (26) mg/g; range 11-7- 86 mg/g).
Recent findings limiting immunological and photosensitizing hazards of the tetrachlorodecaoxygen anion complex (TCDO) in wound healing promotion
Authors: K.W. STAHL, F.W. KUHNE, E.M. WEILER
Journal: British Journal of Dermatology (1986)

Journal Article Recent findings limiting immunological and photosensitizing hazards of the tetrachlorodecaoxygen anion complex (TCDO) in wound healing promotion Get access K.W. STAHL, K.W. STAHL OXO Research, Technology Park, Neuenheimerfeld 517, D‐6900 Heidelberg Search for other works by this author on: Oxford Academic Google Scholar F.W. KÜHNE, F.W. KÜHNE OXO Research, Technology Park, Neuenheimerfeld 517, D‐6900 Heidelberg Search for other works by this author on: Oxford Academic Google Scholar E.M. WEILER E.M. WEILER Centre for Dermatology, University Hospital, Marburg, Federal Republic of Germany Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 115, Issue s31, 1 August 1986, Pages 142–147, https://doi.org/10.1111/j.1365-2133.1986.tb02126.x Published: 01 August 1986
Laser assisted bioprinting of engineered tissue with high cell density and microscale organization
Authors: Bertrand Guillotin, Agnès Souquet, Sylvain Catros, Martí Duocastella, Benjamin Pippenger, Séverine Bellance, Reine Bareille, Murielle Rémy, Laurence Bordenave, Joëlle Amédée, Fabien Guillemot
Journal: Biomaterials (2010)
Natural history of dyspepsia
Authors: L Agreus
Journal: Gut (2002)

Many individuals in the Western world suffer from heartburn, acid regurgitation, abdominal pain, or bowel habit disturbances. The reported prevalence of dyspepsia is approximately 25% with similar values for gastro-oesophageal reflux disease. While prevalence rates are stable over time, substantial changes occur in the main symptom profiles of sufferers. The economic costs of dyspepsia are considerable.
A comparison of neurocognitive functioning in children previously randomized to dexamethasone or prednisone in the treatment of childhood acute lymphoblastic leukemia
Authors: Nina S. Kadan-Lottick, Pim Brouwers, David Breiger, Thomas Kaleita, James Dziura, Haibei Liu, Lu Chen, Megan Nicoletti, Linda Stork, Bruce Bostrom, Joseph P. Neglia
Journal: Blood (2009)
Symptoms of Depression in Cardiac Failure
Authors: David J. Fish, John A. Dillon
Journal: New England Journal of Medicine (1953)

THE case reported below concerns a patient who, during a period of intense emotional stress, had signs and symptoms of organic disease that were diagnosed as purely functional because of the emotional background.Case ReportB. B., a 43-year-old spinster, was first seen by a psychiatrist (D. J. F.) on February 27, 1953, with the chief complaint of extreme nervousness.She stated that her symptoms had begun approximately 2 years previously, when her father, to whom she was strongly attached, suffered a stroke. She gave up her work to care for him and manage their home. The mother was also . . .
Maintenance therapy with gradual reduction of the interferon dose over one year improves histological response in patients with chronic hepatitis C with biochemical response: results of a randomized trial
Authors: Laurent Alric, Michel Duffaut, Janik Selves, Karine Sandre, Marius Mularczyck, Jacques Izopet, Herve Desmorat, Christophe Bureau, Nadia Chaouche, Bernard Dalbergue, Jean-Pierre Vinel
Journal: Journal of Hepatology (2001)
Nephron Deficiency and Predisposition to Renal Injury in a Novel One-Kidney Genetic Model
Authors: Xuexiang Wang, Ashley C. Johnson, Jan M. Williams, Tiffani White, Alejandro R. Chade, Jie Zhang, Ruisheng Liu, Richard J. Roman, Jonathan W. Lee, Patrick B. Kyle, Leah Solberg-Woods, Michael R. Garrett
Journal: Journal of the American Society of Nephrology (2014)

Some studies have reported up to 40% of patients born with a single kidney develop hypertension, proteinuria, and in some cases renal failure. The increased susceptibility to renal injury may be due, in part, to reduced nephron numbers. Notably, children who undergo nephrectomy or adults who serve as kidney donors exhibit little difference in renal function compared with persons who have two kidneys. However, the difference in risk between being born with a single kidney versus being born with two kidneys and then undergoing nephrectomy are unclear. Animal models used previously to investigate this question are not ideal because they require invasive methods to model congenital solitary kidney. In this study, we describe a new genetic animal model, the heterogeneous stock-derived model of unilateral renal agenesis (HSRA) rat, which demonstrates 50%-75% spontaneous incidence of a single kidney. The HSRA model is characterized by reduced nephron number (more than would be expected by loss of one kidney), early kidney/glomerular hypertrophy, and progressive renal injury, which culminates in reduced renal function. Long-term studies of temporal relationships among BP, renal hemodynamics, and renal function demonstrate that spontaneous single-kidney HSRA rats are more likely than uninephrectomized normal littermates to exhibit renal impairment because of the combination of reduced nephron numbers and prolonged exposure to renal compensatory mechanisms (i.e., hyperfiltration). Future studies with this novel animal model may provide additional insight into the genetic contributions to kidney development and agenesis and the factors influencing susceptibility to renal injury in individuals with congenital solitary kidney.
IVY POISONING: ITS TREATMENT AND PREVENTION
Authors: James B. McNair
Journal: JAMA (1925)

To the Editor:  —Krause and Weidman, in their paper (The Journal, June 27, p. 1996) on the preventive treatment of ivy poisoning, state that Schamberg introduced the method involving the introduction of tincture of Rhus toxicodendron by mouth in 1919.  The use of products from the poison ivy group of plants as remedies to Rhus dermatitis has a history similar to the general history of isopathy. However, as these poisonous Rhus plants are native to North America and Asia only, the beginnings of the use of isopathic remedies in this instance is to be looked for in these countries and not in Europe.  A review of the literature shows that, in the treatment of Rhus dermatitis, Rhus charcoal and Rhus ashes have been used externally; and Rhus infusions and Rhus tinctures have been used internally; and Rhus tinctures have been used hypodermically. There are also instances of Rhus poisoning from
It Would Indeed Be Remarkable
Authors: Russell L. Malcolm
Journal: JAMA (1975)

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