tbuckley/cabot-search huggingface dataset:
Editor of Journal of American Medical Association.
Authors: R. Tilley
Journal: JAMA (1883)

<h3>Dear Sir:</h3> —In your issue of the 15th inst., page 683, the reporter in the discussion about jequirity in the Chicago Medical Society, has so seriously misquoted me that I must in justice to myself ask of you to correct it. I am represented as saying that " a small quantity of hyd. chl. cor. would increase the efficiency of the remedy." I stated that the inflammation and consequent advantage was unquestionably due to the presence of bacteria, and that an interesting observation would be to know whether the infusion made with a weak solution of bichloride of mercury would destroy its action. Yours truly,
Acyclic retinoid induces partial differentiation, down-regulates telomerase reverse transcriptase mRNA expression and telomerase activity, and induces apoptosis in human hepatoma-derived cell lines
Authors: Ichiro Yasuda, Yoshimune Shiratori, Seiji Adachi, Akihiro Obora, Masao Takemura, Masataka Okuno, Yoshihiro Shidoji, Mitsuru Seishima, Yasutoshi Muto, Hisataka Moriwaki
Journal: Journal of Hepatology (2002)
BCG immunisation of infants by percutaneous multiple puncture.
Authors: D. B. Cundall, D. J. Ashelford, S. B. Pearson
Journal: BMJ (1988)

New diagnoses made after investigation ofunexpected abnormal results ofurine testing Diagnosis No * Long delay before referral (> 12 hours) * Fever * Purulent effluent (and third lavage bag cloudy) * Obvious infection around the catheter * Poor general condition (malnutrition) * Immune suppression * Recent abdominal surgery (for example, catheter insertion) * Recent peritonitis (< 15 days) * Abnormal peritoneal cavity (for example, hernia) * Abnormal peritoneum (for example, asbestosis) * Disconnect systems for attachment of lavage bags
831 HIGH DOSE VERSUS LOW DOSE HEPATIC ARTERIAL INFUSION CHEMOTHERAPY FOR INTRACTABLE, ADVANCED HEPATOCELLULAR CARCINOMA – PROSPECTIVE RANDOMIZED TRIAL
Authors: S.H. Bae, H.Y. Woo, J.Y. Choi, S.K. Yoon, S.G. Kim, Y.S. Kim, J.Y. Park, K.H. Han, B.K. Jang, J.S. Hwang, J.Y. Cheong, S.W. Cho, Y.S. Seo, H.J. Yim, S.H. Um
Journal: Journal of Hepatology (2009)
Glyburide-reversible cardioprotective effect of BMS-180448 is independent of action potential shortening
Authors: G. J. Grover, A. J. D'Alonzo, T. Hess, P. G. Sleph, R. B. Darbenzio
Journal: Cardiovascular Research (1995)

Objective: We determined if action potential duration (APD) shortening and cardioprotection are separable phenomena in ATP-sensitive potassium channel (KATP) openers which protect ischemic myocardium via a glyburide-reversible mechanism. Methods: We determined the effect of the weakly vasodilating KATP opener, BMS-180448, and the less cardiac-selective cromakalim, on APD in normal, hypoxic or ischemic guinea pig papillary muscles or isolated hearts and compared their APD effects with their cardioprotective activity in isolated guinea pig hearts. Results: In isolated ischemic guinea pig hearts, cromakalim and BMS-180448 had similar cardioprotective potencies (EC25 of 3.2 and 3.3 μM, respectively, for increasing time to the onset of contracture). At 10 μM, BMS-180448 produced no APD shortening, yet was equally protective at this concentration compared to cromakalim, which produced profound APD shortening under either hypoxic or ischemic conditions. The cardioprotective effects of both compounds at 10 μM were abolished by 0.3 μM glyburide. Conclusions: APD shortening is not correlated with cardioprotective activity for BMS-180448 and cromakalim while their cardioprotective effects are abolished by glyburide. These results suggest the possibility of reduced proarrhythmic activity in some KATP openers and that their cardioprotective activity is not associated with sarcolemmal KATP opening.
Supravalvular Aortic Stenosis in Association with Mental Retardation and a Certain Facial Appearance
Authors: A. J. BEUREN, J. APITZ, D. HARMJANZ
Journal: Circulation (1962)

Four patients with supravalvular aortic stenosis are reported. In three of these patients a certain facial resemblance was striking, and these three patients were also mentally and physically retarded. The cases are very similar to the four cases recently reported in the literature. Supravalvular aortic stenosis in association with mental retardation and a certain facial appearance may constitute a previously unrecognized clinical syndrome. A systolic thrill and murmur most pronounced in the first right intercostal space and just below the clavicle, with an empty vascular pedicle on the roentgenogram, may be a clue to the clinical diagnosis of supravalvular aortic stenosis. Supravalvular aortic stenosis is best demonstrated by left ventriculography. A collateral circulation between the coronary arteries and the internal mammary artery has been shown in one patient.
The Cost-effectiveness of HMG-CoA Reductase Inhibitors to Prevent Coronary Heart Disease
Authors: Vivian H. Hamilton
Journal: JAMA (1995)

To evaluate the lifetime cost-effectiveness of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors for treatment of high blood cholesterol levels.We added cost data to a validated coronary heart disease (CHD) prevention computer model that estimates the benefits of lifelong risk factor modification. The updated model takes into account the costs of cholesterol reduction, the savings in CHD health care costs attributable to intervention, the additional non-CHD costs resulting from patients' living longer, and the beneficial effects of reducing CHD risk by reducing total cholesterol and increasing high-density lipoprotein cholesterol (HDL-C).Men and women aged 30 to 70 years who were free of CHD, had total cholesterol levels equal to the 90th percentile of the US distribution in their age and sex group, had HDL-C levels equal to the mean of the US distribution in their age and sex group, and were either with or without additional CHD risk factors.Use of 20 mg of lovastatin per day, which on average reduces total serum cholesterol by 17% and increases HDL-C by 7%.Cost per year of life saved after discounting benefits and costs by 5% annually.The increase in HDL-C associated with lovastatin lowered cost-effectiveness ratios by approximately 40%, such that the treatment of hypercholesterolemia was relatively cost-effective for men (as low as $20,882 per year of life saved at age 50 years) and women ($36,627 per year of life saved at age 60 years) with additional risk factors. Non-CHD costs resulting from longer life expectancy after intervention added at most 23% to the cost-effectiveness ratios for patients who began treatment at age 70 years, and as little as 3% for patients at age 30 years.The cost-effectiveness of HMG-CoA reductase inhibitors varied widely by age and sex and was sensitive to the presence of non-lipid CHD risk factors. The additional non-CHD costs due to increased life expectancy may be significant for the elderly. Accounting for the drug effects of raising HDL-C levels increased the proportion of the population for which medication treatment was relatively cost-effective.
Molecular and cytogenetic characterization of a new case of t(5;17)(q35;q21) variant acute promyelocytic leukemia
Authors: C Nicci, E Ottaviani, S Luatti, T Grafone, M Tonelli, M R Motta, M Malagola, G Marzocchi, G Martinelli, M Baccarani, N Testoni
Journal: Leukemia (2005)
Effects of cirrhosis and ageing on the elimination and bioavailability of ranitidine.
Authors: C J Young, T K Daneshmend, C J Roberts
Journal: Gut (1982)

The plasma concentrations of ranitidine after oral and intravenous administration have been measured in 10 healthy young adults, nine cirrhotic patients, and eight healthy elderly people. In the first of these bioavailability was 51 +/- 4% and half life 161 +/- 11 minutes after oral and 124 +/- 5 minutes after intravenous administration. In the cirrhotics bioavailability was increased to 70 +/- 7%, clearance was reduced, and there was a modest increase in half life. In the elderly bioavailability was similar to that in young adults, clearance was markedly reduced, and half life was prolonged to 241 +/- 7 minutes after oral and 194 +/- 11 minutes after intravenous administration. It is predicted that blood levels in cirrhotics and the elderly would be 50 to 60% higher than in healthy young adults after repeated oral administration of similar doses.
Fluoride release process of (resin-modified) glass-ionomer cements versus (polyacid-modified) composite resins
Authors: Ronald M.H. Verbeeck, Erna A.P. De Maeyer, Luc A.M. Marks, Roeland J.G. De Moor, A.M.J.C. De Witte, Luc M. Trimpeneers
Journal: Biomaterials (1998)
Is thyrotropin-releasing hormone a novel neuroendocrine modulator of keratin expression in human skin?
Authors: Y. Ramot, G. Zhang, T. Bíró, L. Langbein, R. Paus
Journal: British Journal of Dermatology (2013)

Hair and epithelial keratins constitute the major structural components of the skin and its appendages, including the hair fibre. While it is appreciated that selected steroid hormones regulate specific keratins, little is known about the neuroendocrine control of human hair keratin expression. Preliminary evidence had suggested that thyrotropin-releasing hormone (TRH) may regulate keratin gene transcription.To clarify whether TRH operates as a novel neuroendocrine regulator of human hair and epithelial keratin expression under physiologically relevant conditions in situ.Microdissected human female scalp hair follicles (HFs) and female scalp skin were treated in serum-free organ culture for 12 h to 6 days with 100 ng mL(-1) TRH or vehicle. Both quantitative immunohistomorphometry and quantitative real-time polymerase chain reaction were utilized to assess expression of selected keratins.TRH significantly increased expression of the hair keratins K31 and K32, while that of K85 and K86, and of the epithelial keratins K14 and K17, was reduced. In the interfollicular epidermis, TRH stimulated expression of K6, K14 and K17, both at the mRNA and protein levels. Stimulation of the same keratins was also evident in the eccrine sweat and sebaceous glands.Selected human hair and epithelial keratins are modulated in situ. This may be relevant to explain hair shaft growth-promoting effects of TRH. Our pilot study suggests that the neuroendocrine controls that regulate the expression of human keratins deserve more systematic exploration and that these may be harnessed therapeutically.
SOME CLINICAL OBSERVATIONS IN RECTAL DISEASES.
Authors: B. SHERWOOD-DUNN
Journal: JAMA (1899)

There is no surgeon of much experience in rectal surgery but has encountered from time to time cases of PRURITUS ANI that defied all his efforts for relief. I have lately discovered, in several of my cases, a cause for chronic pruritus, which has heretofore escaped my attention, and may possibly not have been observed by others. I therefore speak of it in the hope that it may be a source of enlightenment in many cases that have perplexed physicians. I refer to the discovery—in three late instances—of a small superficial ulcer placed between the internal and external sphincters, showing on the posterior surface, but which may be also sometimes found on the anterior surface of the gut, and in the latter situation is very likely to be unnoticed. When one is at a loss to account for any case of pruritus ani, I would therefore advise that this
Bile acid excretion: the alternate pathway in the hamster.
Authors: R Galeazzi, N B Javitt
Journal: Journal of Clinical Investigation (1977)

The quantitative significance of renal excretion of bile acid ester sulfates as an alternate excretory pathway was evaluated in hamsters. After bile duct ligation, total serum bile acid fell from a mean level of 454 microgram/ml at 24 h to 64 microgram/ml by 96 h. During this period the bulk of the bile acid pool could be accounted for as esterified bile acids in urine. Renal pedicle ligation of animals with bile duct obstruction led to retention of the bile acid ester sulfates in serum. Thioacetamide hepatotoxicity diminished ester sulfation of bile acids causing diminished renal secretion with relatively greater retention of nonesterified bile acids in serum. We conclude that secretion of esterified bile acids by the kidney is an efficient alternate pathway for maintaining bile acid excretion in obstructive biliary tract disease. Coexistent hepatocellular disease diminishes ester sulfation and the effectiveness of the alternate pathway in maintaining bile acid excretion.
Disease-associated missense mutations in the EVH1 domain disrupt intrinsic WASp function causing dysregulated actin dynamics and impaired dendritic cell migration
Authors: Austen J. J. Worth, Joao Metelo, Gerben Bouma, Dale Moulding, Marco Fritzsche, Bertrand Vernay, Guillaume Charras, Giles O. C. Cory, Adrian J. Thrasher, Siobhan O. Burns
Journal: Blood (2012)
Real-time magnetic resonance imaging for integrated identification, targeting, and injection of labeled stem cells to porcine myocardial infarction
Authors: Alexander J. Dick, Michael A. Guttman, Venkatesh K. Raman, Dana C. Peters, Jonathan M. Hill, Scott Smith, Greig Scott, Elliot R. McVeigh, Robert J. Lederman
Journal: Journal of the American College of Cardiology (2003)
Morphologic Changes in Erythrocytes in Hypertriglyceridemia
Authors: Emily A Coberly, Richard D Hammer
Journal: New England Journal of Medicine (2014)

A 39-year-old woman with a history of gestational diabetes was admitted with epigastric pain from acute pancreatitis. She had no history of hyperlipidemia, but multiple blood samples were grossly lipemic, and serum triglyceride levels were markedly increased.
Patient's sex does not affect use of thrombolysis
Authors: R. Raine, T. Crayford, J. Chambers
Journal: BMJ (1998)

Editor—Wenger's review of the importance of coronary heart disease in American women is equally applicable to women in Britain.1 Wenger points out that the prognosis is influenced by access to clinical interventions, and she suggests that underuse of thrombolysis in women may have a cascade effect on risk stratification.

Her assertion that patients who have had thrombolytic treatment seem more likely to undergo investigation is unreferenced. In addition, the study quoted as showing lower use of thrombolysis …
Lymphocyte Transformation Induced by Autologous Cells: Stimulation by Cultured Lymphoblast Lines
Authors: Marc E. Weksler, Gary Birnbaum
Journal: Journal of Clinical Investigation (1972)

The ability of cultured lymphoblasts to stimulate autologous lymphocyte transformation in "one-way" mixed leukocyte culture has been studied. Intact, cultured lymphoblasts required physical contact with responding lymphocytes to induce transformation. In quantitative terms, lymphocytes incorporate as much thymidine when mixed with irradiated cultured lymphoblasts as they do in response to phytohemagglutinin. The stimulation of lymphocyte transformation by allogeneic cultured lymphoblasts did not parallel the stimulation of lymphocyte transformation by leukocytes from the donor of the lymphoblast culture. The stimulatory determinants on the cultured lymphoblast are unaffected by neuraminidase but destroyed by trypsin. The trypsin-treated cultured lymphoblasts regain their capacity to stimulate autologous lymphocyte transformation within 48 hr in culture. Cultured lymphoblasts possess concanavalin A binding sites. Concanavalin A inhibits the capacity of cultured lymphoblasts to stimulate autologous lymphocyte transformation. The relevance of these findings to EB virus infection of cultured lymphoblasts and to immune surveillance is discussed.
Suicide during pregnancy and in the first postnatal year.
Authors: L Appleby
Journal: BMJ (1991)

To calculate age adjusted mortality ratios for suicide by women in the first year after childbirth and during pregnancy, and to identify characteristics of postnatal suicide in childbearing women.Retrospective study based on population data for England and Wales from 1973 to 1984.Women aged 15-44 who committed suicide in the year after childbirth or during pregnancy.Observed to expected mortality ratios for the total postnatal sample, for five year age groups, for unmarried mothers, and for suicide after stillbirth; observed to expected mortality ratios for all suicides during pregnancy and for five year age groups; the timing of suicides in relation to delivery; and the frequency of the various methods of suicide.The standardised mortality ratio for postnatal suicide was calculated to be 0.17--that is, the actual total was only one sixth of that expected. The low ratio was not found after stillbirth, which was associated with a rate six times that in all women after childbirth. The low ratio was less pronounced, but still present, in teenage mothers and in unmarried mothers. Women who committed suicide after childbirth most often did so in the first month, and there was a tendency to use violent methods. The standardised mortality ratio for suicide during pregnancy was calculated to be 0.05 of all pregnant women. Teenagers were at substantially increased risk.Women in the first year after childbirth and during pregnancy have a low risk of suicide despite their high rate of psychiatric morbidity. Underreporting of maternal suicides is unlikely to explain the findings, though it may affect their magnitude. Motherhood seems to protect against suicide. Concern for dependants may be an important focus for suicide prevention in clinical practice.
Enhanced Induction by High-Cholesterol Diet of Remnant Gastric Carcinogenesis by N-Methyl-N'-nitro-N-nitrosoguanidine in Rats
Authors: M. Makino, N. Kaibara, S. Koga
Journal: JNCI Journal of the National Cancer Institute (1989)

The influence of bile acids on the development of remnant gastric carcinoma was examined by investigating the incidence of carcinogenesis in noninbred male Wistar rats treated orally with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG; CAS 70-25-7; 1-methyl-3-nitro-1-nitrosoguanidine) and fed a diet containing 1% cholesterol. The high-cholesterol diet did not influence the incidence of carcinoma in the nongastrectomized, MNNG-treated groups of rats. However, in the gastrectomized groups, the incidence of carcinoma was significantly higher in the group given the high-cholesterol diet (60.6%) than in the group given a normal diet (35.5%). Histologically undifferentiated adenocarcinoma was recognized more frequently in the high-cholesterol-diet group. Three gastrectomized rats not treated with MNNG but fed the high-cholesterol diet developed remnant gastric carcinoma (13%), whereas none of the rats given the normal diet did. Because the fecal excretion of bile acids increased significantly in the rats fed the high-cholesterol diet and the gastroduodenal reflux of bile acids was probably accelerated, the increase in the incidence of carcinogenesis in the remnant stomach was considered to be the result of the increase in the reflux of bile acids evoked by a high-cholesterol diet.
Helping the Newly Blind
Authors: W. Askew, J. C. Colligan
Journal: BMJ (1951)

Overweight and obesity are increasing worldwide and now reach about one-third of the world9s population. Obesity also involves patients with inflammatory arthritis. Knowing the impact of obesity on rheumatic diseases (rheumatoid arthritis, ankylosing spondylitis and psoriatic arthritis) is thus an important issue. This article first reviews the epidemiological and clinical data available on obesity in inflammatory rheumatic diseases, that is, its impact on incident disease, disease characteristics and the therapeutic response. The second part of this review gives an overview of the factors potentially involved in the specifics of inflammatory arthritis in patients with obesity, such as limitations in the clinical assessment, diet, microbiota and adipokines.
Coombs' Positive Reactions Associated With Cephaloridine Therapy
Authors: Paul S. York
Journal: JAMA (1968)

<h3>To the Editor:—</h3> A flurry of cases in which difficulty was encountered in minor side crossmatching of blood for transfusion led to an investigation with the following findings: (1) All of the patients were on the urology service. (2) The difficulty coincided in time with a clinical study of cephaloridine by the urology department. (3) Only patients who had received cephaloridine had this problem. The abnormality encountered was a positive reaction to a direct Coombs' test (DCT) on the minor side of the crossmatch (agglutination of the patients' erythrocytes by antihuman globulin reagent). <h3>Report of Cases:—</h3> Because of this observation 37 patients receiving daily injections of 2 to 4 gm of cephaloridine were subjected to the DCT. In eight of these patients the DCT was found positive while none of 420 other crossmatches had a positive DCT. A review of the records of the patients with positive DCT revealed a
A Miniaturized Multipurpose Platform for Rapid, Label‐Free, and Simultaneous Separation, Patterning, and In Vitro Culture of Primary and Rare Cells
Authors: Tohid Fatanat Didar, Kristen Bowey, Guillermina Almazan, Maryam Tabrizian
Journal: Advanced Healthcare Materials (2013)

Abstract Given that current cell isolation techniques are expensive, time consuming, yield low isolation purities, and/or alter target cell properties, a versatile, cost effective, and easy‐to‐operate microchip with the capability to simultaneously separate, capture, pattern, and culture rare and primary cells in vitro is developed. The platform is based on target cell adhesion onto the micro‐fabricated interfaces produced by microcontact printing of cell‐specific antibodies. Results show over 95% separation efficiency in less than 10 min for the separation of oligodendrocyte progenitor cells (OPCs) and cardiomyocytes from rat brain and heart mixtures, respectively. Target cell attachment and single cell spreading can be precisely controlled on the basis of the designed patterns. Both cell types can maintain their biofunctionality. Indeed, isolated OPCs can proliferate and differentiate into mature oligodendrocytes, while isolated cardiomyocytes retain their contractile properties on the separation platform. Successful separation of two dissimilar cell types present in varying concentrations in their respective cell mixtures and the demonstration of their integrity after separation open new avenues for time and cost‐effective sorting of various cell types using the developed miniaturized platform.
Alcohol-dependent doctors.
Authors: M M Glatt
Journal: BMJ (1979)

constituents in the two groups was in exact proportion to the machine-smoked yields of the two types of product.This means that any long-term benefits from switching to a low-tar cigarette are better than the hitherto published short-term switching studies would suggestprovided that any dose-response relationship between "disease" and "tar" intake regresses toward zero, and cigarette consumption does not increase.
Value of Cutaneous Angiomas in the Arteriographic Localization of Spinal-Cord Arteriovenous Malformations
Authors: John L. Doppman, Fremont P. Wirth, Giovanni Di Chiro, Ayub K. Ommaya
Journal: New England Journal of Medicine (1969)

A careful search for segmentally related cutaneous hemangiomas in a series of 28 patients with spinal-cord arteriovenous malformations revealed six with such an association, a much higher prevalence than previously reported. Close scrutiny of the back is required to detect these often minor skin changes. Selective arteriography demonstrated opacification of both the spinal and the cutaneous vascular malformation from the same intercostal or lumbar artery, confirming the similar metameric origin of both lesions. Recognition of the skin lesion in a patient with obscure spinal-cord symptoms is important both as a clue to the etiology of the myelopathy and as an aid in the localization of arterial feeders to the spinal malformation before surgery.