ACE Inhibitors for Scleroderma Renal Crisis
Authors: Noemi Esparza, Andrés Purroy, Liliana Mesa
Journal: Annals of Internal Medicine (1991)

Letters1 February 1991ACE Inhibitors for Scleroderma Renal CrisisNoemi Esparza, MD, Andrés Purroy, DM, DPhil, Liliana Mesa, MDNoemi Esparza, MDSearch for more papers by this author, Andrés Purroy, DM, DPhilSearch for more papers by this author, Liliana Mesa, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-114-3-249 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: We read with great interest the review by Steen and colleagues (1) on the outcome of scleroderma renal crisis before and after the availability of angiotensin converting enzyme (ACE) inhibitors. Of the 55 patients in the study who had scleroderma renal crisis, the continuation or acceleration of renal insufficiency in 4 patients raised the question of captopril-related renal toxicity. The authors concluded that Captopril could not have caused renal deterioration in these patients because none of the 4 patients had peripheral blood or urine eosinophilia or improvement of renal failure after withdrawal of captopril.We wish to...References1. Steen V, Costantino J, Shapiro A, and Medsger T. Outcome of renal crisis in systemic sclerosis: Relation to availability of angiotensin converting enzyme (ACE) inhibitors. Ann Intern Med. 1990;113: 352-7. LinkGoogle Scholar2. Luderer J, Schoolwerth A, Sinicrope R, Ballard J, Lookingbill D, and Hayes A. Acute renal failure, hemolytic anemia and skin rash associated with captopril therapy. Am J Med. 1981;71:493-500. CrossrefMedlineGoogle Scholar3. Grünfeld J, Kleinknecht D, and Droz D. Acute interstitial nephritis. In: Schrier RW, Gotlschalk CW, eds. Diseases of the Kidney, v 5. Boston: Little, Brown and Company; 1988:1461-87. Google Scholar1. Steen V, Costantino J, Shapiro A, and Medsger T. Outcome of renal crisis in systemic sclerosis: relation to availability of angiotensin converting enzyme (ACE) inhibitors. Ann Intern Med. 1990;113: 352-7. LinkGoogle Scholar2. Traub Y, Shapiro A, and Rodnan G. Hypertension and renal failure (scleroderma renal crisis) in progressive systemic sclerosis. Medicine (Baltimore). 1983;62:335-52. CrossrefMedlineGoogle Scholar1. Steen V, Costantino J, Shapiro A, and Medsger T. Outcome of renal crisis in systemic sclerosis: relation to availability of angiotensin converting enzyme (ACE) inhibitors. Ann Intern Med. 1990;113: 352-7. LinkGoogle Scholar2. Loutzenhiser R and Epstein M. Effects of calcium antagonists on renal hemodynamics. Am J Physiol. 1985;249:F619-29. MedlineGoogle Scholar3. Palier M. Effects of the prostaglandin E analog misoprostil on cyclosporine nephrotoxicity. Transplantation. 1988;45:1126-31. CrossrefMedlineGoogle Scholar1. Steen V, Costantino J, Shapiro A, and Medsger T. Outcome of renal crisis in systemic sclerosis: relation to availability of angiotensin converting enzyme (ACE) inhibitors. Ann Intern Med. 1990;113: 352-7. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Noemi Esparza, MD; Andrés Purroy, DM, DPhil; Liliana Mesa, MDAffiliations: Universidad de Navarra 31080 Pamplona Spain PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMMP-12 Deficiency Attenuates Angiotensin II-Induced Vascular Injury, M2 Macrophage Accumulation, and Skin and Heart Fibrosis 1 February 1991Volume 114, Issue 3Page: 249-250KeywordsACE inhibitorsAngiotensin converting enzymeBloodEosinophiliaRenal failureSclerodermaToxicityUrine ePublished: 1 December 2008 Issue Published: 1 February 1991 PDF downloadLoading ...