tbuckley/cabot-search huggingface dataset:
Association between Lung Function in Adults and Plasma DDT and DDE Levels: Results from the Canadian Health Measures Survey
Authors: Ming Ye, Jeremy Beach, Jonathan W. Martin, Ambikaipakan Senthilselvan
Journal: Environmental Health Perspectives (2014)

Although DDT [1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane] has been banned in many countries since the 1970s, it may still pose a risk to human respiratory health. In agriculture, DDT exposures have been associated with asthma and chronic bronchitis. However, little is known about the effect of DDT on lung function.We used data on 1,696 participants 20-79 years of age from the Canadian Health Measures Survey (CHMS) and conducted multiple regression analysis to estimate associations between plasma p,p´-DDT/DDE and lung function.Almost all participants (> 99.0%) had detectable concentrations of plasma p,p´-DDE, but only 10.0% had detectable p,p´-DDT. Participants with detectable p,p´-DDT had significantly lower mean FVC (difference = 311 mL; 95% CI: -492, -130; p = 0.003) and FEV1 (difference = 232 mL; 95% CI: -408, -55; p = 0.015) than those without. A 100-ng/g lipid increase in plasma p,p´-DDE was associated with an 18.8-mL decrease in mean FVC (95% CI: -29, -9) and an 11.8-mL decrease in mean FEV1 (95% CI: -21, -3). Neither exposure was associated with FEV1/FVC ratio or FEF25%-75%.DDT exposures, which may have occurred decades ago, were still detectable among Canadians. Plasma DDT and DDE were negatively associated with lung function parameters. Additional research on the potential effects of DDT use on lung function is warranted.
Mode of delivery and survival in babies weighing less than 2000 g at birth.
Authors: M L Smith, S A Spencer, D Hull
Journal: BMJ (1980)

A retrospective study of babies weighing less than 2000 g at birth admitted over a four-year period to Nottingham City Hospital Neonatal Unit showed a higher incidence of lower Apgar scores and the need for intubation in babies born by caesarean section and breech deliveries. Mortality in those delivered by the breech (35%) was statistically higher than those by caesarean section (10%) or vertex (14%). It is concluded that small babies born by breech delivery have a higher mortality than when delivered vaginally and should have the benefit of caesarean section.
Treatment of Bell Palsy
Authors: John F. Steiner
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MEDICALLY MANAGED PATIENTS WITH NON ST SEGMENT ACUTE CORONARY SYNDROMES HAVE HETEROGENOUS OUTCOMES, BASED ON PERFORMANCE OF ANGIOGRAPHY, EXTENT OF ANGIOGRAPHIC DISEASE AND AGE
Authors: Philippe Steg, Etienne Puymirat, Emmanuel Sorbets, Laurent J. Feldman, Meyer Elbaz, Bernard Ritz, Arnaud Hueber, Tabassome Simon, Nicolas Danchin
Journal: Journal of the American College of Cardiology (2013)
Japan tackles dioxin levels
Authors: C. Wallerstein
Journal: BMJ (1999)

Authorities in Japan are taking urgent steps to counter the potentially harmful effects of high concentrations of dioxin in the environment.

Recycling is almost unheard of in this heavily industrialised nation, where at least 75%of all waste is burnt, and Japan has 10 times more incinerators than the United States. Around 90%of the country's emissions of dioxin, a known carcinogen, are reported …
Data Discrepancies in Meta-analyses That Use Standarized Mean Differences—Reply
Authors: Peter C. Gøtzsche, Britta Tendal
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Looming Shortage of Physicians Raises Concerns About Access to Care
Authors: Mike Mitka
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Case of Verruca Planae Juveniles
Authors: CHALMERS WATSON
Journal: British Journal of Dermatology (1903)

Journal Article Case of Verruca Planæ Juveniles Get access CHALMERS WATSON, M.B., F.R.C.P.E. CHALMERS WATSON, M.B., F.R.C.P.E. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 15, Issue 5, 1 May 1903, Pages 178–181, https://doi.org/10.1111/j.1365-2133.1903.tb16498.x Published: 01 May 1903
Detection of Breast Cancer
Authors: Myron Moskowitz
Journal: JAMA (1986)

<h3>To the Editor.—</h3> In the article by Wertheimer et al,<sup>1</sup>the statement is made that there would not be enough radiologists available to analyze the mammograms. This is an incorrect assumption based on wishful thinking rather than fact. There are at least 20 000 radiologists active in this country today who are members of the American College of Radiology. There are other radiologists who are not active members. If there are, indeed, 50 million women older than age 40 years (the census projections for 1990 as indicated by these authors), it would be necessary for every radiologist to examine 2500 women per year, which, assuming 208 working days, would require that each radiologist perform 12 mammograms a day. In Falun, Sweden, one radiologist routinely examines 100 women a day, and in the Breast Cancer Detection Demonstration Project, examinations of 40 women each day were routinely done. In our own
A focused parameter update: Hereditary angioedema, acquired C1 inhibitor deficiency, and angiotensin-converting enzyme inhibitor–associated angioedema
Authors: Bruce L. Zuraw, Jonathan A. Bernstein, David M. Lang, Timothy Craig, David Dreyfus, Fred Hsieh, David Khan, Javed Sheikh, David Weldon, David I. Bernstein, Joann Blessing-Moore, Linda Cox, Richard A. Nicklas, John Oppenheimer, Jay M. Portnoy, Christopher R. Randolph, Diane E. Schuller, Sheldon L. Spector, Stephen A. Tilles, Dana Wallace
Journal: Journal of Allergy and Clinical Immunology (2013)
Lymphoma-Associated “Ivory Rib”
Authors: Kenneth S Stewart, Donald L Steinweg
Journal: New England Journal of Medicine (2003)

An 81-year-old woman was admitted with increasing generalized weakness, anorexia, and a weight loss of 7 kg (15 lb) over the previous three months. The only finding on physical examination was marked cachexia. Laboratory evaluation revealed anemia (hemoglobin level, 7.4 g per deciliter), leukocytosis (white-cell count, 15,400 per cubic millimeter), and thrombocytosis (platelet count, 450,000 per cubic millimeter). The chest radiograph showed a sclerotic 11th rib on the right side (Panel A, arrows). Subsequent bone scanning showed homogeneous uptake along the entire affected rib (Panel B, arrows). Bone marrow biopsy and rib biopsy led to a diagnosis of diffuse large-cell . . .
Essential and Partially Overlapping Role of CD3γ and CD3δ for Development of αβ and γδ T Lymphocytes
Authors: Baoping Wang, Ninghai Wang, Mariolina Salio, Arlene Sharpe, Deborah Allen, Jian She, Cox Terhorst
Journal: The Journal of Experimental Medicine (1998)

CD3γ and CD3δ are two highly related components of the T cell receptor (TCR)–CD3 complex which is essential for the assembly and signal transduction of the T cell receptor on mature T cells. In gene knockout mice deficient in either CD3δ or CD3γ, early thymic development mediated by pre-TCR was either undisturbed or severely blocked, respectively, and small numbers of TCR-αβ+ T cells were detected in the periphery of both mice. γδ T cell development was either normal in CD3δ−/− mice or partially blocked in CD3γ−/− mice. To examine the collective role of CD3γ and CD3δ in the assembly and function of pre-TCR and in the development of γδ T cells, we generated a mouse strain with a disruption in both CD3γ and CD3δ genes (CD3γδ−/−). In contrast to mice deficient in either CD3γ or CD3δ chains, early thymic development mediated by pre-TCR is completely blocked, and TCR-αβ+ or TCR-γδ+ T cells were absent in the CD3γδ−/− mice. Taken together, these studies demonstrated that CD3γ and CD3δ play an essential, yet partially overlapping, role in the development of both αβ and γδ T cell lineages.
Baseline Ad5 serostatus does not predict Ad5 HIV vaccine–induced expansion of adenovirus-specific CD4+ T cells
Authors: Natalie A Hutnick, Diane G Carnathan, Sheri A Dubey, George Makedonas, Kara S Cox, Lisa Kierstead, Sarah J Ratcliffe, Michael N Robertson, Danilo R Casimiro, Hildegund C J Ertl, Michael R Betts
Journal: Nature Medicine (2009)
Statin Therapy Accelerates Reendothelialization
Authors: Dirk H. Walter, Kilian Rittig, Ferdinand H. Bahlmann, Rudolf Kirchmair, Marcy Silver, Toshinori Murayama, Hiromi Nishimura, Douglas W. Losordo, Takayuki Asahara, Jeffrey M. Isner
Journal: Circulation (2002)

Background — Primary and secondary prevention trials suggest that statins possess favorable effects independent of cholesterol reduction. We investigated whether statin therapy may also accelerate reendothelialization after carotid balloon injury. Methods and Results — Simvastatin treatment in 34 male Sprague-Dawley rats accelerated reendothelialization of the balloon-injured arterial segments (reendothelialized area at 2 weeks, 12.3±1.8 versus 5.4±1.1 mm 2 , P &lt; 0.01) and resulted in a dose-dependent (0.2 or 1 mg/kg IP) significant reduction in neointimal thickening at 2, 3, and 4 weeks compared with saline-injected controls (n=18). To elucidate the mechanism, we investigated the contribution of bone marrow–derived endothelial progenitor cells (EPCs) by bone marrow transplantation from Tie2/lacZ mice to background mice or nude rats. X-gal staining of mouse carotid artery specimens revealed a 2.9-fold increase in the number of β-gal–positive cells per square millimeter appearing on the carotid artery luminal surface at 2 weeks, and double-fluorescence immunohistochemistry disclosed a significant 5-fold increase in the number of double-positive cells (β-gal, isolectin B4) on the luminal surface in carotid arteries of statin-treated nude rats (20±3 versus 4±1 cells/mm surface length, P &lt;0.005). Statins increased circulating rat EPCs (2.4-fold at 2 weeks and 2.5-fold at 4 weeks, P &lt;0.001) and induced adhesiveness of cultured human EPCs by upregulation of the integrin subunits α 5 , β 1 , α v , and β 5 of human EPCs as shown by reverse transcription–polymerase chain reaction and fluorescence-activated cell sorting. Conclusions — These findings establish additional mechanisms by which statins may specifically preempt disordered vascular wall pathology and constitute physiological evidence that EPC mobilization represents a functionally relevant consequence of statin therapy.
FDA told to act to wean US citizens off high salt diet
Authors: B. Roehr
Journal: BMJ (2010)

The US Food and Drug Administration has been called on to regulate the amount of sodium added to foods after a report found that several decades of voluntarily efforts to reduce the unacceptably high levels of sodium that US citizens consume have failed. 

The report by the Institute of Medicine found that the average US citizen consumes 3400 milligrams of sodium a day, more than double the 1500 mg believed to be an adequate intake for a person under the age of 50 (older people need less). More than three quarters of sodium comes from processed and restaurant foods. The report recommends reducing consumption to 2300 …
Primary Care: Balancing Health Needs, Services, and Technology
Authors: Robert A. Witzburg
Journal: Annals of Internal Medicine (1999)

Medical Writings: Book Notes18 May 1999Primary Care: Balancing Health Needs, Services, and TechnologyRobert A. Witzburg, MDRobert A. Witzburg, MDBoston University School of Medicine, Boston, Massachusetts. (Witzburg)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-130-10-199905180-00030 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Starfield B. 438 pages. New York: Oxford Univ Pr; 1998. $49.95. ISBN 0195125428. Order phone 800-451-7556.Field of medicine: Health policy and health services.Format: Clothbound book.Audience: Physicians; health care professionals; and others involved in the study, development, or management of health systems.Purpose: To elucidate the role of primary care as an organizing focus for health care systems and to explore the empirical data on its effectiveness.Content: This book is a compilation of important work that defines the role of primary care as a clinical discipline and as a building block for health care systems. The first ... Author, Article, and Disclosure InformationAuthors: Robert A. Witzburg, MDAffiliations: Boston University School of Medicine, Boston, Massachusetts. (Witzburg) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySex, Immigration, and Patterns of Access to Primary Care in CanadaCurrent management of adults receiving oral anti-cancer medications: A scoping review protocolCurrent management of adults receiving oral anti-cancer medications: A scoping review protocolCurrent management of adults receiving oral anti-cancer medications: A scoping review protocolCurrent management of adults receiving oral anti-cancer medications: A scoping review protocol 18 May 1999Volume 130, Issue 10 Page: 868 Keywords Computer software Health care Health care policy Information technology Medical services Primary care ePublished: 15 August 2000 Issue Published: 18 May 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
AMA's Bureau of Investigation exposed fraud
Authors: Terra Ziporyn
Journal: JAMA (1985)

The American Medical Association has had a longstanding interest in debunking patent medicines and exposing quacks. Besides its campaign against patent medicine advertisement in the early 20th century (see main story), in fact, for many years the AMA's Bureau of Investigation analyzed suspicious nostrums and alerted both the medical profession and the public to unscrupulous promoters. Originally headed by Arthur J. Cramp, MD, the bureau was formed in 1906 under the name "Propaganda Department." (Until about 1920, "propaganda" simply meant information.) This department prepared abstracts of government reports on the chemical composition of nostrums seized in interstate commerce. It also arranged to have many widely advertised nostrums examined in the AMA's Chemical Laboratory and published the results inThe Journal. Later years brought increased activity to the department, whose name was changed to the Bureau of Investigation in 1925. The bureau added other forms of quackery to its investigations and
Effect of Oxygen Therapy on Oedema in Patients with Cor Pulmonale
Authors: P. Effersoe, H. S. Kristensen, H. C. A. Lassen
Journal: BMJ (1960)

prominent and distressing feature.The attack resembles closely that described by Baybutt (1959) in an infant who had received a first injection of gamma-globulin, but in that instance both parents had suffered from severe allergic disease.Though the patient survived, the response to treatment was disappointing.Adrenaline, which was used perhaps in too small doses, had a very temporary effect on the asthma, and even large doses of antihistamine and steroids did not control the urticaria and vomiting for 48 hours.My impression was that large doses of sodium phenobarbitone were more valuable than all the other measures, and, given the same situation again, I would use sedatives earlier.Again in retrospect, the trial dose of tetanus antitoxin was too large, though it may be noted that the patient did not give a personal or family history of allergic disease.Parish, Laurent, and Moynihan (1957) suggest 0.2 ml. of a 1 in 10 dilution for subjects with a history of allergy, but a I in 100 dilution (with tenfold increments at intervals of half an hour) would be safer, though somewhat more tedious.The invalidism caused by serum sickness, the difficult decisions on whether to give tetanus antitoxin or not which face the casualty surgeon, and the occasional frightening reaction such as the present one, should give a stimulus to a bigger campaign of active immunization.The considerable hazards of injecting tetanus antitoxin and the even greater risks of tetanus can both be eradicated by an all-out drive to increase active immunization.Personal records of all preventive inoculations-and of allergy, etc.-are very important.Summary A woman casualty officer developed urticarial swelling of the eyelids after giving tetanus antitoxin.Despite the absence of an allergic history, a test dose of 0.2 ml. of a 1 in 10 dilution of tetanus antitoxin precipitated a severe and prolonged allergic reaction.The asthma, urticaria, vomiting, and collapse lasted 48 hours, but subsided after adrenaline, antihistamines, and 1,900 mg. of hydrocortisone.It is presumed that the patient was sensitized by tetanus antitoxin entering the conjunctival sacs.The intense reaction to a test dose of tetanus antitoxin confirmed the high degree of sensitivity which had developed.Such cases can be avoided only if a more vigorous active immunization campaign succeeds in making passive immunization unnecessary.I wish to acknowledge the help given by Dr.
Eosinophilic granuloma of the lung presenting as a solitary pulmonary nodule.
Authors: C J Fichtenbaum, G M Kleinman, R G Haddad
Journal: Thorax (1990)

A symptomless 58 year old man had an eosinophilic granuloma of the lung that presented as a solitary pulmonary nodule rather than the usual diffuse reticulonodular shadow on the chest radiograph. Only one previous case presenting in this way has been described.
Immune deficiency caused by impaired expression of nuclear factor-κB essential modifier (NEMO) because of a mutation in the 5′ untranslated region of the NEMO gene
Authors: Jana L. Mooster, Caterina Cancrini, Alessandra Simonetti, Paolo Rossi, Gigliola Di Matteo, Maria Luisa Romiti, Silvia Di Cesare, Luigi Notarangelo, Raif S. Geha, Douglas R. McDonald
Journal: Journal of Allergy and Clinical Immunology (2010)
P7 Radical treatment for lung cancer: impact of recent service improvements: Abstract P7 Table 1.
Authors: M Gornasa, H Essa, H Sheikh, R Shah, SCO Taggart
Journal: Thorax (2013)

<h3>Introduction</h3> The Salford Lung Cancer Service (SLCS) has introduced a number of improvements in care including PET-CT scanning (2005), EBUS (2008), a Northwest Sector MDT for treatment decisions (2009), CPEX testing (2009), IMRT/stereotactic radiotherapy (2011) and development of a surgical high risk MDT (2011). The SLCS holds a data-base of all patients having surgery or radical radiotherapy (DXT) each year since 2000. This study sets out to review our performance for patients receiving either surgery or radical DXT from 2005 to 2012. <h3>Methods</h3> The data-base was used in parallel to reviewing each patient record to determine surgical procedure, presence or absence of pre-operative or pre-DXT histology and final tumour stage. For comparative analysis of the effect of these new developments on service delivery, each year was pooled into 2 main groups; Group A (2005–2008) and Group B (2009–2012). Tests for significance were performed using Chi-Squared tables at 5% level. <h3>Results</h3> Overall, a total of 178 patients underwent surgery and 138 DXT (See Table). Patients receiving surgery or DXT increased by 62% &amp; 46% respectively from Group A to B although no evidence of any significant change in the proportion of patients having surgery compared with DXT was seen between Group A/B (p = 0.75). Compared with 2005 (n = 18), 29 patients underwent surgery in 2012 (p = 0.08). The proportion of wedge/segmentectomy resections (W/S) doubled over time although this change did not reach significance (p = 0.22). Similar non-significant changes in the proportion of surgical patients with stage 1 disease (p = 0.92), post-operative N2 disease (p = 0.81) and pre-operative histology (p = 0.58) were observed between Group A/B. In contrast, the rate of pre-DXT histology increased significantly from 34% to 65% (p = 0.0007). Overall concordancy between pre-operative and final histology was 97%. In 6 patients not having pre-operative histology, the final diagnosis was malignant neuroendocrine tumour. <h3>Conclusions</h3> Improvements in the SLCS over the last 4 years have led to parallel rises in surgical and DXT rates. The rise in surgery numbers likely reflects better patient selection and increase in use of W/S whereas that for DXT appears to be the result of improved diagnostics reflected by significantly higher rates of histological diagnosis.