tbuckley/cabot-search huggingface dataset:
Ocular Findings after Allogeneic Hematopoietic Stem Cell Transplantation
Authors: Khalid F. Tabbara, Ahmad Al-Ghamdi, Fahad Al-Mohareb, Mouhab Ayas, Naeem Chaudhri, Fahad Al-Sharif, Hazzaa Al-Zahrani, Said Y. Mohammed, Amr Nassar, Mahmoud Aljurf
Journal: Ophthalmology (2009)
PATIENTS WITH DIABETES MELLITUS AND CORONARY ARTERY DISEASE EXHIBIT HIGHER CAROTID ATHEROSCLEROTIC PLAQUE INFLAMMATION: INSIGHTS FROM A NEW NONINVASIVE METHOD
Authors: Maria I. Drakopoulou, Konstantinos Toutouzas, Georgios Benetos, Pavlos Bounas, Andreas Synetos, Archontoula Michelongona, Charalampos Grassos, Eleftherios Tsiamis, Elias Siores, Christodoulos Stefanadis
Journal: Journal of the American College of Cardiology (2014)
Antineoplastic Drugs as an Occupational Hazard in Hospitals
Authors: LINDA S. FORST
Journal: Annals of Internal Medicine (1985)

Letters and Corrections1 September 1985Antineoplastic Drugs as an Occupational Hazard in HospitalsLINDA S. FORST, M.D., M.S.LINDA S. FORST, M.D., M.S.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-103-3-473-1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The hazards of handling antineoplastic agents by hospital personnel are not mentioned by Patterson and associates (1) in their excellent review of occupational hazards in hospitals. Exposure occurs during mixing, administering, and disposing of these agents. In addition, disposal includes not only the vials and syringes but also contaminated materials used for cleaning spills and urine of patients receiving chemotherapy.The need for regulation of handling is obvious when one considers studies reporting the carcinogenicity of these drugs in laboratory animals; second tumors arising in patients receiving chemotherapy (2); mutagenicity of urine from nurses who handle cytotoxic...References1. PATTERSONCRAVENSCHWARTZNARDELLKASMERNOBLE WDDEJJ. Occupational hazards to hospital personnel. Ann Intern Med. 1985;102:658-80. LinkGoogle Scholar2. ADAMSONSIEBER RS. Antineoplastic agents as potential carcinogens. In: HIATT H, WATSON J, WINSTEN J. Origins of Human Cancer. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory; 1977:435. Google Scholar3. FALCKGROHNSORSAVAINIOHEINONENHOLSTI KPMHEL. Mutagenicity in urine of nurses handling cytostatic drugs. Lancet. 1979;1:1250. CrossrefMedlineGoogle Scholar4. WAKSVIKKLEPPBROGGER HOA. Chromosome analysis of nurses handling cytostatic agents. Cancer Treat Rep. 1981;65:607-10. MedlineGoogle Scholar5. CRUDISTEPHENS CB. Antineoplastic agents: an occupational hazard? Natl Intravenous Ther Assoc. 1981;4:233. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Cook County Hospital Chicago, IL 60612 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNickel, Ruthenium, Rhodium, Palladium, Osmium, and PlatinumNickel, Ruthenium, Rhodium, Palladium, Osmium, and PlatinumCYTOTOXIC DRUG RECONSTITUTION AT THE KUWAIT CANCER CONTROL CENTREOccupational Hazard from Antineoplastic AgentsWILLIAM B. PATTERSON, M.D. 1 September 1985Volume 103, Issue 3Page: 473-473KeywordsChemotherapyDrug regulationDrugsResearch laboratoriesUrine Issue Published: 1 September 1985 PDF downloadLoading ...
Dialysis of Body Cavity Fluid
Authors: R. K. Ausman, Luis Krause, Nathan T. Back
Journal: JAMA (1963)

THE ABNORMAL ACCUMULATION of fluid within the thoracic or abdominal cavities or both is a condition associated with a number of pathological entities. Prominent among these disturbances is the presence of disseminated malignant implants which can produce a recurrent effusion of massive proportions. Symptomatic relief is obtained by paracentesis or thoracentesis, but unfortunately the withdrawal of fluid is required at increasingly frequent intervals. It has been shown<sup>1</sup>that a significant protein content exists in the evacuated material when carcinomatosis is the stimulating factor. Ultimately, the patient suffers from severe malnutrition as protein anabolism fails to rebuild the lost substances. <h3>Technique</h3> A concept involving the retrieval of protein lost when fluid is removed was suggested recently.<sup>2</sup>Recovery is managed by collecting the aspirated material under sterile conditions, concentrating it by dialysis, and infusing it intravenously in the same way plasma is administered. Widespread use of the method has been
Hemorheological alterations, decreased cerebral microvascular oxygenation and cerebral vasomotion compensation in sickle cell patients
Authors: Xavier Waltz, Aurélien Pichon, Danièle Mougenel, Nathalie Lemonne, Marie‐Laure Lalanne‐Mistrih, Stéphane Sinnapah, Vanessa Tarer, Benoit Tressières, Yann Lamarre, Maryse Etienne‐Julan, Olivier Hue, Marie‐Dominique Hardy‐Dessources, Philippe Connes
Journal: American Journal of Hematology (2012)

Sickle cell anemia (SS) is characterized by a reduced cerebral microvascular oxygen saturation (cerebral TOI), which is not associated with hemoglobin concentration. Cerebral TOI has never been studied in sickle cell-hemoglobin C disease (SC). We focused on the relationships between hemorheological alterations and cerebral TOI in sickle cell patients with no cerebral vasculopathy and on the usefulness of TOI variability to assess the cerebral vasomotion activity. The blood rheological profile, the level of cerebral TOI (spatial resolved spectroscopy) and the cerebral TOI variability, which reflects vasomotion activity, were compared between 20 healthy subjects (AA), 21 SC patients, and 21 SS patients. Cerebral TOI exhibited the following order: AA > SC > SS. The low cerebral TOI in SS patients was related to red blood cell aggregation and deformability properties. The cerebral TOI variability of SS and SC patients was increased above healthy values and vasomotion activity was negatively associated with the reduced cerebral TOI in SS patients. We demonstrated that (1) blood rheology could be involved in the reduced cerebral TOI in SS patients but not in SC patients; (2) vasomotion activity is increased in SS and SC patients to compensate for the reduced cerebral TOI.
Margery Shaw, MD, JD: twice counselor
Authors: William A. Check
Journal: JAMA (1982)

Geneticist and lawyer Margery Shaw is profiled and the work of Houston's Institute for the Interprofessional Study of Health Law is discussed. Dr. Shaw, interim director of the Institute, offers her perspectives on current issues in health law, among them the personhood of the fetus and its implications for patient care, wrongful birth and wrongful life suits, and a proposed federal regulation concerning adolescents, contraceptives, and parental notification. Her research in genetics and her theories of genetic counseling and reproductive responsibilities are also touched upon.
Abstract 3846: SGEF is over-expressed in advanced glial tumors and mediates glioma cell invasion and survival
Authors: Shannon P. Fortin, Johnathon Rollo, Kimberly Paquette, Amanda Chan, Juli Ross, Marc Symons, Nhan L. Tran
Journal: Cancer Research (2011)

Abstract Glioblastoma multiforme (GBM) is the most malignant of all primary adult brain tumors, histopathologically characterized by the infiltrative capacity of glioma cells to diffuse into the surrounding normal brain. There are currently no anti-invasion therapies available, and thus the identification and functional understanding of genes that mediate malignant tumor cell dispersion could lead to the discovery of molecular targets which have the potential to respond to therapeutics. We have previously shown that several guanine nucleotide exchange factors for Rho family small GTPases are overexpressed in GBM tumors and play important roles in glioma invasion. Here we report a role for SGEF, a guanine nucleotide exchange factor (GEF) for RhoG, in mediating glioma invasion. SGEF mRNA expression increases in correlation with glioma grade and, within GBM tumors, levels of SGEF expression inversely correlate with patient survival. siRNA-mediated depletion of SGEF decreases in vitro glioma cell migration and ex vivo glioma cell invasion. In addition, genome-wide determination of NF-κB controlled genes in temozolomide-resistant primary GBM xenografts (GBM14-TMZ-R) revealed an increased occupancy of NF-κB on the SGEF gene promoter region via ChIP-on-chip analysis as compared to the parent primary line. In fact, increased phosphorylation of IkBa was detected in GBM-14-TMZ-R. Moreover, inhibition of NF-κB in GBM14-TMZ-R significantly decreases SGEF gene expression, and activation of the NF-κB pathway by TWEAK in GBM cells induces SGEF mRNA expression. Furthermore, siRNA-mediated depletion of SGEF expression enhances chemotherapy-induced cell death in glioma cells. Understanding the role of SGEF in promoting cell motility and chemotherapeutic resistance may direct the development of novel targeted therapeutics for GBM. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3846. doi:10.1158/1538-7445.AM2011-3846
Causal linkage between insulin suppression of lipolysis and suppression of liver glucose output in dogs.
Authors: K Rebrin, G M Steil, S D Mittelman, R N Bergman
Journal: Journal of Clinical Investigation (1996)

Suppression of hepatic glucose output (HGO) has been shown to be primarily mediated by peripheral rather than portal insulin concentrations; however, the mechanism by which peripheral insulin suppresses HGO has not yet been determined. Previous findings by our group indicated a strong correlation between free fatty acids (FFA) and HGO, suggesting that insulin suppression of HGO is mediated via suppression of lipolysis. To directly test the hypothesis that insulin suppression of HGO is causally linked to the suppression of adipose tissue lipolysis, we performed euglycemic-hyperinsulinemic glucose clamps in conscious dogs (n = 8) in which FFA were either allowed to fall or were prevented from falling with Liposyn plus heparin infusion (LI; 0.5 ml/min 20% Liposyn plus 25 U/min heparin with a 250 U prime). Endogenous insulin and glucagon were suppressed with somatostatin (1 microgram/min/kg), and insulin was infused at a rate of either 0.125 or 0.5 mU/min/kg. Two additional experiments were performed at the 0.5 mU/min/kg insulin dose: a double Liposyn infusion (2 x LI; 1.0 ml/min 20% Liposyn, heparin as above), and a glycerol infusion (19 mg/min). With the 0.125 mU/min/kg insulin infusion, FFA fell 40% and HGO fell 33%; preventing the fall in FFA with LI entirely prevented this decline in HGO. With 0.5 mU/min/kg insulin infusion, FFA levels fell 64% while HGO declined 62%. Preventing the fall in FFA at this higher insulin dose largely prevented the fall in HGO; however, steady state HGO still declined by 18%. Doubling the LI infusion did not further affect HGO, suggesting that the effect of FFA on HGO is saturable. Elevating plasma glycerol levels did not alter insulin's ability to suppress HGO. These data directly support the concept that insulin suppression of HGO is not direct, but rather is mediated via insulin suppression of adipose tissue lipolysis. Thus, resistance to insulin control of hepatic glucose production in obesity and/or non-insulin-dependent diabetes mellitus may reflect resistance of the adipocyte to insulin suppression of lipolysis.
Comparison of melanoma guidelines in the U.S.A., Canada, Europe, Australia and New Zealand: a critical appraisal and comprehensive review
Authors: Z.V. Fong, K.K. Tanabe
Journal: British Journal of Dermatology (2013)

There are several well-established guidelines for the staging of melanoma and the size of excisional margins, along with recommendations for sentinel lymph node biopsy. Guidelines have been proposed in the U.S.A. (National Comprehensive Cancer Network), Canada (Cancer Care Ontario and Canadian Medical Association), Europe (European Society for Medical Oncology) and Australia and New Zealand (Australian Cancer Network). The guidelines set by these groups are largely based on current evidence, or expert panel consensus where evidence is lacking. The recommendations are more controversial and varying where there is a lack of level-one evidence in the literature (e.g. screening, adjuvant therapy, follow-up intensity). We review the evidence and available literature for the management of melanoma worldwide.
Sp1 and Sp3 transcription factors are required for trans-activation of the human SERCA2 promoter in cardiomyocytes
Authors: M Brady
Journal: Cardiovascular Research (2003)

Objectives: The sarcoplasmic reticulum (SR) Ca2+ ATPase (SERCA) is essential to the removal of cytosolic calcium following cardiac contraction, and its abundance and activity are significantly altered during perinatal development and in failing myocardium. The objective of the current study was to identify cis regulatory elements and nuclear transcription factors responsible for transactivating SERCA2 gene expression in cardiomyocytes. Methods: Primary cultures of neonatal rat ventricular myocytes were transiently transfected with luciferase (LUX) reporter gene constructs containing deletions of the SERCA2 promoter or which harbored mutations in consensus Sp1 transcription factor binding sites. Cotransfection assays, electrophoretic mobility shift, and supershift assays were also performed to delineate the regulatory role of specific transcription factors. Results: We identified a putative AP-1-like element and a consensus Egr-1 binding site, but neither Egr-1 nor 12-O-tetradecanoylphorbol 13-acetate (TPA) significantly modified human SERCA2 promoter activity in vitro. Maximal activity of the SERCA2 promoter required the proximal 177 bp, and strong activation was observed with a 125-bp construct, within which an Sp1 site and a CAAT box were important. Mutation analysis also revealed the importance of two Sp1 sites between −125 and −200. Sp1 and Sp3 transcription factors were subsequently identified to bind to oligonucleotide probes corresponding to only the two most proximal Sp1 sites. Conclusions: These studies provide direct evidence that regulation of human SERCA2 gene expression in cardiomyocytes depends on transactivation events elicited by Sp1 and Sp3 transcription factors.
Urinary Tract Infections in Older Women
Authors: Lona Mody, Manisha Juthani-Mehta
Journal: JAMA (2014)

Asymptomatic bacteriuria and symptomatic urinary tract infections (UTIs) in older women are commonly encountered in outpatient practice.To review management of asymptomatic bacteriuria and symptomatic UTI and review prevention of recurrent UTIs in older community-dwelling women.A search of Ovid (Medline, PsycINFO, Embase) for English-language human studies conducted among adults aged 65 years and older and published in peer-reviewed journals from 1946 to November 20, 2013.The clinical spectrum of UTIs ranges from asymptomatic bacteriuria, to symptomatic and recurrent UTIs, to sepsis associated with UTI requiring hospitalization. Recent evidence helps differentiate asymptomatic bacteriuria from symptomatic UTI. Asymptomatic bacteriuria is transient in older women, often resolves without any treatment, and is not associated with morbidity or mortality. The diagnosis of symptomatic UTI is made when a patient has both clinical features and laboratory evidence of a urinary infection. Absent other causes, patients presenting with any 2 of the following meet the clinical diagnostic criteria for symptomatic UTI: fever, worsened urinary urgency or frequency, acute dysuria, suprapubic tenderness, or costovertebral angle pain or tenderness. A positive urine culture (≥105 CFU/mL) with no more than 2 uropathogens and pyuria confirms the diagnosis of UTI. Risk factors for recurrent symptomatic UTI include diabetes, functional disability, recent sexual intercourse, prior history of urogynecologic surgery, urinary retention, and urinary incontinence. Testing for UTI is easily performed in the clinic using dipstick tests. When there is a low pretest probability of UTI, a negative dipstick result for leukocyte esterase and nitrites excludes infection. Antibiotics are selected by identifying the uropathogen, knowing local resistance rates, and considering adverse effect profiles. Chronic suppressive antibiotics for 6 to 12 months and vaginal estrogen therapy effectively reduce symptomatic UTI episodes and should be considered in patients with recurrent UTIs.Establishing a diagnosis of symptomatic UTI in older women requires careful clinical evaluation with possible laboratory assessment using urinalysis and urine culture. Asymptomatic bacteriuria should be differentiated from symptomatic UTI. Asymptomatic bacteriuria in older women should not be treated.
Endovascular Aortic Aneurysm Repair
Authors: John R. Kapoor
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Newer Concepts of Whipple's Disease.
Authors: P. R. Holt
Journal: Annals of Internal Medicine (1961)

s1 May 1961Newer Concepts of Whipple's Disease.P. R. Holt, M.D., A. S. Cohen, M.D., K. J. Isselbacher, M.D.P. R. Holt, M.D.Search for more papers by this author, A. S. Cohen, M.D.Search for more papers by this author, K. J. Isselbacher, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-54-5-1049_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWhipple's disease was described and originally considered as an intestinal lipodystrophy. Peroral jejunal biopsy and early exploratory laparatomy have led to a more frequent diagnosis during life, and it has become apparent that the disease is systemic with pathologic involvement of lymph nodes, heart, lungs, and other organs. These tissues show a characteristic infiltration by macrophages filled with periodic acid-Schiff staining inclusions which have now been studied in the electron microscope and which reveal a very striking appearance associated with dense virus-like particles. The significance of these findings will be discussed.It is of importance that while malabsorption is a... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1961Volume 54, Issue 5Page: 1049-1049KeywordsBiopsyCardiovascular therapyElectron microscopyHeart diseasesLipodystrophyLungsLymph nodesPeriodic acid SchiffStainingSystemic diseases ePublished: 1 December 2008 Issue Published: 1 May 1961 PDF downloadLoading ...
Multiple Follicular Papules on the Back of an Elderly Man
Authors: José C. Cardoso, Jonathan Leonard, James Carton, Eduardo Calonje
Journal: JAMA Dermatology (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Hemodialysis Impairs Endothelial Function via Oxidative Stress
Authors: Hiroshi Miyazaki, Hidehiro Matsuoka, Hiroyuki Itabe, Michiaki Usui, Seiji Ueda, Seiya Okuda, Tsutomu Imaizumi
Journal: Circulation (2000)

Background —Patients who undergo hemodialysis experience accelerated atherosclerosis and premature death. Recent evidence suggests that endothelial dysfunction proceeds to and exacerbates atherosclerosis. It remains unknown whether hemodialysis per se causes endothelial dysfunction. Methods and Results —We evaluated endothelial function estimated by flow-mediated vasodilation during reactive hyperemia using high-resolution ultrasound Doppler echocardiography before and after a single session in patients on maintenance hemodialysis. Several studies have shown that the imbalance between pro-oxidant and antioxidant activities in hemodialyzed patients results in high oxidative stress, which causes lipid peroxidation and endothelial injury. Accordingly, we investigated the effects of antioxidative modification during hemodialysis on endothelial function using a vitamin E–coated cellulose membrane dialyzer. Nonspecific endothelium-independent vasodilation was measured after administration of a sublingual glyceryl trinitrate spray (0.3 mg). A single session of hemodialysis by noncoated dialyzer impaired flow-mediated vasodilation ( P &lt;0.05) associated with increased plasma levels of oxidized LDL ( P &lt;0.05), an index of oxidative stress. Hemodialysis by vitamin E–coated membrane prevented dialysis-induced endothelial dysfunction and increases in oxidized LDL. Plasma levels of oxidized LDL were inversely correlated with the magnitudes of flow-mediated vasodilation ( r =−0.53, P &lt; 0.001). Hemodialysis by noncoated or vitamin E–coated membrane did not affect glyceryl trinitrate–induced endothelium-independent vasodilation. Conclusions —Our findings indicate that hemodialysis per se impairs endothelial function, possibly by increasing oxidative stress.