Effect of Long-Term Propranolol Administration on Parathyroid Hormone and Calcium Concentration in Primary Hyperparathyroidism
Authors: JOSE F. CARO
Journal: Annals of Internal Medicine (1979)

Brief Reports1 November 1979Effect of Long-Term Propranolol Administration on Parathyroid Hormone and Calcium Concentration in Primary HyperparathyroidismJOSE F. CARO, M.D., JAIME H. CASTRO, M.D., JOSEPH A. GLENNON, M.D.JOSE F. CARO, M.D., JAIME H. CASTRO, M.D., JOSEPH A. GLENNON, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-91-5-740 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptBeta adrenergic agonists have been shown to stimulate parathyroid hormone (PTH) secretion from isolated parathyroid cells. This action can be blocked with the β-adrenergic antagonist propranolol. This response appears to differ from that due to calcium itself, since β-blockade does not alter tissue response to calcium and high calcium concentration does not suppress the response to β-adrenergic stimuli (1-3). Short-term in-vivo studies in animals (4) and humans (5) have also shown PTH responsiveness to β-adrenergic agonists and elimination of this response by propranolol.We recently found that propranolol significantly decreased serum levels of PTH, alkaline phosphatase, and the incidence of...References1. SHERWOOD L and ABE M. Adrenergic receptors and the release of parathyroid hormone (PTH). J Clin Invest. 1972;51(6):88a. Abstract. Google Scholar2. WILLIAMS G, HARGIS G, BOWSER E, HENDERSON W, and MARTINEZ N. Evidence for a role of adenosine 3′, 5′-monophosphate in parathyroid hormone release. Endocrinology. 1973;92:687-91. CrossrefMedlineGoogle Scholar3. BROWN E, HURWITZ S, WOODARD C, and AURBACH G. Direct identification of beta-adrenergic receptors on isolated bovine parathyroid cells. Endocrinology. 1977;100:1703-9. CrossrefMedlineGoogle Scholar4. FISCHER J, BLUM J, and BINSWANGER U. Acute parathyroid hormone response to epinephrine in vivo. J Clin Invest. 1973;52:2434-40. CrossrefMedlineGoogle Scholar5. KUKREJA S, HARGIS G, BOWSER E, HENDERSON W, FISHERMAN E, and WILLIAMS G. Role of adrenergic stimuli in parathyroid hormone secretion in man. J Clin Endocrinol Metab. 1975;40:478-81. CrossrefMedlineGoogle Scholar6. CARO J, BESARAB A, BURKE J, and GLENNON J. A possible role for propranolol in the treatment of renal osteodystrophy. Lancet. 1978;2:451-3. CrossrefMedlineGoogle Scholar7. CARO J and BESARAB A. Propranolol therapy for hyperparathyroidism? Lancet. 1978;1:827. Letter. CrossrefMedlineGoogle Scholar8. BROWN E, GARDNER D, WINDECK R, HURWITZ S, BRENNAN M, and AURBACH G. β-Adrenergically stimulated adenosine 3′,5′-monophosphate accumulation in and parathyroid hormone release from dispersed human parathyroid cells. J Clin Endocrinol Metab. 1979;48:618-26. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOSE F. CARO, M.D.; JAIME H. CASTRO, M.D.; JOSEPH A. GLENNON, M.D.Affiliations: University of Rochester School of Medicine Rochester, New YorkThomas Jefferson University Philadelphia, Pennsylvania PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNephrolithiasis in Primary HyperparathyroidismMedical Management of Primary HyperparathyroidismCoexisting Hyperthyroidism Abstract and Primary Hyperparathyroidism with Vitamin D-Deficient Osteomalacia in a Vietnamese Immigrantβ-Adrenergic blockade for the treatment of hyperthyroidismMedical management of asymptomatic primary hyperparathyroidismDisorders of Calcium MetabolismCirculatory and metabolic aspects of β-adrenoceptor blockadeSerum magnesium, calcium, phosphate and PTH following long-term beta-blockade in ischaemic heart diseasePrimary Hyperparathyroidism and Delirium in The Elderlyβ-Adrenergic BlockersPrevention of parathyroid hormone-dependent nephrocalcinosis by chronic administration of the organic phosphorothioate WR-2721HyperparathyroidismDiagnosis of HyperparathyroidismParathyroid Hormone and CalcitoninEffect of bromocriptine on serum PTH, calcium and phosphate levels in azotemic ratsConjugated Estrogens in the Treatment of Postmenopausal Women with HyperparathyroidismROBERT MARCUS, M.D., PHILIP MADVIG, M.D., MARILYN CRIM, M.D., Ph.D., ALLAN PONT, M.D., JON KOSEK, M.D.Surgery of the ParathyroidsMultiple endocrine neoplasia syndromesEffetti Del Blocco Beta-Adrenergico Sulla Secrezione Di Paratormone Nell'Iperparatiroidismo Primitivo Con Nefrolitiasi Calcica RecidivanteMineral Metabolism in Health and DiseaseTreatment of HypercalcemiaThe Medical Management of Primary HyperparathyroidismJOHN P. 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