tbuckley/cabot-search huggingface dataset:
Short-time-scale left ventricular systolic dynamics. Evidence for a common mechanism in both left ventricular chamber and heart muscle mechanics.
Authors: K B Campbell, S G Shroff, R D Kirkpatrick
Journal: Circulation Research (1991)

Based on the premise that short-time-scale, small-amplitude pressure/volume/outflow behavior of the left ventricular chamber was dominated by dynamic processes originating in cardiac myofilaments, a prototype model was built to predict pressure responses to volume perturbations. In the model, chamber pressure was taken to be the product of the number of generators in a pressure-bearing state and their average volumetric distortion, as in the muscle theory of A.F. Huxley, in which force was equal to the number of attached crossbridges and their average lineal distortion. Further, as in the muscle theory, pressure generators were assumed to cycle between two states, the pressure-bearing state and the non-pressure-bearing state. Experiments were performed in the isolated ferret heart, where variable volume decrements (0.01-0.12 ml) were removed at two commanded flow rates (flow clamps, -7 and -14 ml/sec). Pressure responses to volume removals were analyzed. Although the prototype model accounted for most features of the pressure responses, subtle but systematic discrepancies were observed. The presence or absence of flow and the magnitude of flow affected estimates of model parameters. However, estimates of parameters did not differ when the model was fitted to flow clamps with similar magnitudes of flows but different volume changes. Thus, prototype model inadequacies were attributed to misrepresentations of flow-related effects but not of volume-related effects. Based on these discrepancies, an improved model was built that added to the simple two-state cycling scheme, a pathway to a third state. This path was followed only in response to volume change. The improved model eliminated the deficiencies of the prototype model and was adequate in accounting for all observations. Since the template for the improved model was taken from the cycling crossbridge theory of muscle contraction, it was concluded that, in spite of the complexities of geometry, architecture, and regional heterogeneity of function and structure, crossbridge mechanisms dominated the short-time-scale dynamics of left ventricular chamber behavior.
Pemphigus vegetans with IgG and IgA antidesmoglein 3 antibodies
Authors: S. Morizane, T. Yamamoto, Y. Hisamatsu, K. Tsuji, T. Oono, T. Hashimoto, K. Iwatsuki
Journal: British Journal of Dermatology (2005)

Journal Article Pemphigus vegetans with IgG and IgA antidesmoglein 3 antibodies Get access S. Morizane, S. Morizane Department of Dermatology, Okayama University Graduate School of Medicine and Dentistry, 2‐5‐1 Shikata‐cho, Okayama 700‐8558, Japan Department of Dermatology, Kurume University School of Medicine, Fukuoka, Japan S. Morizane. E‐mail: gmd14058@cc.okayama‐u.ac.jp Search for other works by this author on: Oxford Academic Google Scholar T. Yamamoto, T. Yamamoto Department of Dermatology, Okayama University Graduate School of Medicine and Dentistry, 2‐5‐1 Shikata‐cho, Okayama 700‐8558, Japan Department of Dermatology, Kurume University School of Medicine, Fukuoka, Japan Search for other works by this author on: Oxford Academic Google Scholar Y. Hisamatsu, Y. Hisamatsu Department of Dermatology, Okayama University Graduate School of Medicine and Dentistry, 2‐5‐1 Shikata‐cho, Okayama 700‐8558, Japan Department of Dermatology, Kurume University School of Medicine, Fukuoka, Japan Search for other works by this author on: Oxford Academic Google Scholar K. Tsuji, K. Tsuji Department of Dermatology, Okayama University Graduate School of Medicine and Dentistry, 2‐5‐1 Shikata‐cho, Okayama 700‐8558, Japan Department of Dermatology, Kurume University School of Medicine, Fukuoka, Japan Search for other works by this author on: Oxford Academic Google Scholar T. Oono, T. Oono Department of Dermatology, Okayama University Graduate School of Medicine and Dentistry, 2‐5‐1 Shikata‐cho, Okayama 700‐8558, Japan Department of Dermatology, Kurume University School of Medicine, Fukuoka, Japan Search for other works by this author on: Oxford Academic Google Scholar T. Hashimoto, T. Hashimoto Department of Dermatology, Okayama University Graduate School of Medicine and Dentistry, 2‐5‐1 Shikata‐cho, Okayama 700‐8558, Japan Department of Dermatology, Kurume University School of Medicine, Fukuoka, Japan Search for other works by this author on: Oxford Academic Google Scholar K. Iwatsuki K. Iwatsuki Department of Dermatology, Okayama University Graduate School of Medicine and Dentistry, 2‐5‐1 Shikata‐cho, Okayama 700‐8558, Japan Department of Dermatology, Kurume University School of Medicine, Fukuoka, Japan Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 153, Issue 6, 1 December 2005, Pages 1236–1237, https://doi.org/10.1111/j.1365-2133.2005.06956.x Published: 01 December 2005
Adefovir dipivoxil for the treatment of lamivudine-resistant hepatitis B mutants
Authors: Robert Perrillo, Eugene Schiff, Eric Yoshida, Ann Statler, Kenneth Hirsch, Teresa Wright, Klaus Gutfreund, Patrick Lamy, Alison Murray
Journal: Hepatology (2000)

Lamivudine has been shown to be an effective therapy for chronic hepatitis B, but resistance to this nucleoside agent is common after prolonged use. Five patients with chronic hepatitis B virus (HBV) infection developed resistance to lamivudine after 9 to 19 months of treatment. In 4 patients this occurred after liver transplantation and the remaining individual had stable cirrhosis. In each case, resistance was confirmed to be caused by one or more mutations in the HBV-DNA polymerase gene and was associated with active underlying liver disease. The patients were treated with adefovir dipivoxil in a dose of 5 to 30 mg daily. Two to 4 log 10 reductions in HBV-DNA levels were observed in 4 cases, and the fifth patient became negative by quantitative polymerase chain reaction (PCR) after retransplantation in conjunction with hepatitis B immunoglobulin (HBIg). Virologic improvement was associated with stable or declining serum alanine transaminase levels in 4 patients. HBV-DNA suppression has been sustained during a mean treatment period of 13 months (range 11 to 15 months), including 1 patient in whom lamivudine has been discontinued. Mild changes in renal function were observed during treatment in most cases but did not require early discontinuation of the drug. This study provides evidence that adefovir dipivoxil can be an effective treatment for lamivudine-resistant HBV mutants as well as wild-type HBV.
Treatment for Psoriatic Arthritis
Authors: Bernard A. Schwetz
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Immunohistological study of the development of the cellular infiltrate in the pelage follicles of the DEBR model for alopecia areata
Authors: JIAN-GANG ZHANG, R.F. OLIVER
Journal: British Journal of Dermatology (1994)

The Dundee experimental bald rat (DEBR) undergoes hair loss associated with perifollicular infiltrates of mononuclear cells (MNC), a pathological characteristic of human alopecia areata (AA). To investigate further the pathogenesis of the disease in this animal model, we have studied the development, composition and extent of the perifollicular MNC infiltration in young (6-week-old), prelesional (3-month-old), active lesional, and established lesional DEBR rats, using 6-week- and 6-month-old Wistar rats as normal controls. The proportions of hair follicles showing infiltration by MNC and their main subsets were determined using immunohistochemical staining of serial cryostat sections of flank skin biopsies. There was a good correlation between the degree of leucocyte (OX-1+) infiltration of anagen hair follicles and the development of hair loss. In 6-week-old DEBR skin, there were few perifollicular cells expressing MHC class II, with positively stained dendritic cells in the dermis above the sebaceous gland. There was a sparse perifollicular distribution of CD4+ cells (W3/25) and macrophages (ED-1+). No CD8+ cells (OX-8+) were seen associated with DEBR hair follicles, and only small numbers were present in Wistar rats. In prelesional DEBR rats there was an increased perifollicular presence of MHC class II+ cells, macrophages, and particularly of CD8+ cells, with little change in CD4+ cells. Active and established lesional rats, i.e. animals with overt loss of hair, showed a significant increase in the degree of MNC infiltration and the proportion of infiltrated follicles, the majority of which were in dystrophic anagen. In the perifollicular infiltrate the CD4+:CD8+ ratio was approximately 2:1. An intrafollicular infiltrate was prominent, and was composed of CD8+ cells and macrophages, with bulbar and suprabulbar keratinocytes expressing MHC class II antigens. CD4+ cells were not detected in follicular epithelium. ICAM-1 expression correlated with MNC infiltration. These results show marked similarities to lesional human AA. They also focus on a possible active role for CD8+ cells in the pathogenesis of hair loss in the DEBR rat.
Fibronectin and laminin expression in sentinel lymph nodes of patients with malignant melanoma
Authors: A. Gradilone, P. Gazzaniga, E. Cigna, F. Vasaturo, B. Vincenzi, O. Gandini, I. Silvestri, D. Ribuffo, S. Scarpa, N. Scuderi, A.M. Aglianò
Journal: British Journal of Dermatology (2007)
Detection of Infected Liver Cysts by 111In WBC SPECT/CT in Polycystic Liver Disease
Authors: Jeffrey Alan Belair, Judith Marie Joyce, Eun Jeong Kwak
Journal: Clinical Nuclear Medicine (2013)

SPECT/CT imaging can provide improved diagnostic information over traditional planar scintigraphy and SPECT, with more precise anatomic localization and observer confidence. We present 2 patients with polycystic liver disease (PCLD), both with constitutional symptoms and bacteremia. In WBC SPECT/CT images revealed increased WBC localization within a single liver cyst in each case, subsequently drained under imaging guidance. Cultures confirmed the presence of infection, allowing for appropriately directed antibiotic therapy and successful treatment outcomes. These cases illustrate the incremental value of In WBC SPECT/CT fusion imaging for the evaluation of bacteremia in complicated patients.
Autoantibodies to the C-terminal subunit of RLIP76 induce oxidative stress and endothelial cell apoptosis in immune-mediated vascular diseases and atherosclerosis
Authors: Paola Margutti, Paola Matarrese, Fabrizio Conti, Tania Colasanti, Federica Delunardo, Antonella Capozzi, Tina Garofalo, Elisabetta Profumo, Rachele Riganò, Alessandra Siracusano, Cristiano Alessandri, Bruno Salvati, Guido Valesini, Walter Malorni, Maurizio Sorice, Elena Ortona
Journal: Blood (2007)
Treatment of enteric fever
Authors: C. M Parry, N. J Beeching
Journal: BMJ (2009)

Fluoroquinolones remain the best option in areas where resistance is uncommon

Enteric fever (typhoid and paratyphoid), caused by Salmonella enterica serovar Typhi or serovar Paratyphi A, represents a major burden of disease in communities that lack clean water and adequate sanitation. More than 27 million cases of enteric fever occur worldwide each year, with 216 000 deaths.1 Community based studies in Asia have shown a yearly incidence greater than 400/100 000 population in infants and children.2 In developed countries, returning travellers or those visiting friends and relatives in their family’s country of origin are at risk.3 In endemic areas, most patients are treated with oral antibiotics as outpatients, and only those with severe disease need hospital admission. Relapse may complicate the illness, and faecal carriage can become chronic and lead to onward transmission. In the linked systematic review (doi:10.1136/bmj.b1865), Thaver and colleagues compare the effectiveness of fluoroquinolones as firstline agents with that of other antibiotics for treating enteric fever.4

Until the late 1980s, two to three …
Preventive cardiology and cardiac rehabilitation
Authors: Aashish Contractor
Journal: British Journal of Sports Medicine (2010)

Cardiovascular disease is the leading cause of death in India. It has reached epidemic proportions, and needs to be addressed through primary and secondary prevention measures. The field of preventive cardiology and cardiac rehabilitation is in its nascent stages in India and these services need to expand widely for the country to effectively manage this epidemic. This talk will focus on the various aspects of cardiac rehabilitation, including cardiovascular disease risk factor reduction, role of exercise in reducing cardiac morbidity and mortality, and the appropriate exercise prescription for those with heart disease.
A CHANGE IN RABBIT FIBROMA VIRUS SUGGESTING MUTATION
Authors: C. H. Andrewes, R. E. Shope
Journal: The Journal of Experimental Medicine (1936)

A strain of rabbit fibroma virus (changed virus) producing partly fibromatous, partly inflammatory, lesions is believed to represent a mixture of the original virus with a strain (inflammatory virus) causing only necrotic and inflammatory lesions. The inflammatory virus does not represent a contamination from without, but probably arose as a mutant from the original strain. The occurrence of mutation amongst viruses and the propriety of using the word in this field are briefly discussed. Consideration is also given to the nature of the change in the virus which leads to a tissue reaction so widely different from that produced by the original strain.
Pulmonary Compliance in Patients with Periodic Breathing
Authors: HAROLD A. LYONS, FRANK BURNO, RICHARD W. STONE
Journal: Circulation (1958)

A study of pulmonary compliance in patients with periodic breathing was made. The elastic properties of the lung were found to be normal in some patients and grossly decreased in others. Two types of periodic breathing mechanics were found: in one there are similar variations of tidal volumes and unchanged pulmonary compliance; in the other a constant fluctuation of the intraesophageal pressure associated with the variations in tidal volume.
Superior vena cava to right pulmonary artery anastomosis: Results in 46 infants and children
Authors: D. Hunt, W. S. Edwards, P. B. Deverall, L. M. Bargeron
Journal: Thorax (1970)

Superior vena cava to right pulmonary artery anastomoses have been constructed in 46 infants and children with cyanotic congenital heart disease associated with low pulmonary blood flow and low pulmonary vascular resistance. All children had lesions not currently amenable to corrective operative procedures. Good or excellent results, albeit with persistent mild to moderate cyanosis, followed operation in 31 children and have been maintained for up to eight years. There were 15 hospital and two late deaths. Although there has been a significant absence of late complications, it is probable that the caval anastomosis results in a fixed level of pulmonary blood flow and thus fixed effort tolerance. Thus, when puberty with its demands for increased physical activity occurs, these patients may require further surgery, such as a systemic to pulmonary artery anastomosis to increase pulmonary blood flow.
Opioid Analgesics—Risky Drugs, Not Risky Patients
Authors: Deborah Dowell, Hillary V Kunins, Thomas A Farley
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Constitutional Hyperbilirubinemia
Authors: Morton P. Eanet, Irving B. Brick
Journal: New England Journal of Medicine (1955)

CONSTITUTIONAL hyperbilirubinemia, or constitutional hepatic dysfunction, is a frequently unrecognized and misdiagnosed form of liver disease, first described in a series of articles by Gilbert and his associates1 2 3 4 5 6 in 1907 as "Cholémie simple familiale." Although this disease is often familial, sporadic cases occur and occasionally present an interesting clinical problem in the differential diagnosis of jaundice.These patients have a mild acholuric jaundice in which hemolytic, hepatic or biliary disease is usually suspected. Most of the cases occur in young adults. The patient may be asymptomatic, but frequently complains of abdominal pain, easy fatigability, anorexia and irritability. The only significant . . .
Relaxation–Systolic Pressure Relation
Authors: Thierry C. Gillebert, Adelino F. Leite-Moreira, Stefan G. De Hert
Journal: Circulation (1997)

Abstract This contribution reviews the regulation of left ventricular pressure (LVP) fall by load and relates this regulation to left ventricular contractility. Load regulation of LVP fall has to be distinguished from neurohumoral regulation, from effects induced by arterial reflected waves and from long-term load effects on contractility. The response of LVP fall to a moderate elevation of systolic LVP is highly variable. It depends on the ratio between the actual systolic pressure and peak isovolumetric pressure, defined as “relative load”. Up to a relative load of 81% to 84%, LVP fall accelerates. Above this relative load, LVP fall decelerates. Depending on the level of relative load there is a wide variety of effects ranging from moderate acceleration of LVP fall to marked deceleration of LVP fall. Acceleration of LVP fall in response to a load elevation is associated with normal cardiac function, while slowing of LVP fall is associated with impaired cardiac function. Similar but opposite effects are observed with reductions of systolic LVP. Effects of changes in systolic LVP on time constant τ reveal a fair correlation with systolic elastance (Ees), peak dP/dt max and regional fractional shortening (or ejection fraction). There is an excellent correlation with measured isovolumetric LVP, indicating that contraction-relaxation coupling is close when contractility is expressed in terms of peak isovolumetric pressure. Assessment of contractility with systolic LVP-relaxation relation is precise and load independent and can be performed with the sole use of a high-fidelity pressure gauge positioned in the left ventricular cavity.
The Aging Process
Authors: Robert K. Finley
Journal: JAMA (1962)

<h3>To the Editor:—</h3> Most things are made better by getting older. Cheese, whisky, furniture, brick houses, and friends improve with age. Cheese gets mellow, whisky gets smoother, furniture softer, brick houses warmer, and friends truer, all with the passage of time. Aging is a dynamic process, a series of reactions between the object and its environment which is continually taking place. These reactions produce subtile changes in the substance, most of which are beneficial. The output of medical literature and related writings is growing by horrifying degrees. New journals are being born at the rate of 100 per year. Their birth acceleration approaches the breeding rate of rabbits. It is estimated that in 2 years there will be 220,000 medical articles appearing in 13,000 medical journals printed on about one million pages. To be current a physician would have to read about 36 journals daily. Cataloguing, abstracting, indexing, binding, and
LEITER'S APPARATUS FOR THE EAR, MODIFIED BY AMBERG.
Authors: EMIL AMBERG
Journal: JAMA (1901)

The modified Leiter's apparatus, for the application of hot and cold water to the ear, is made of inflexible material. The long lead tubing is avoided. The apparatus is slightly bent, adapting itself to the contour of the head. Figures 1 and 2 fully explain the construction. The short tubes can be easily cleansed. Different sizes are required for different ears. The opening of the inlet is about twice as large in diameter as the opening of the outlet. For this latter idea I am indebted to the instrument maker, Charles Karlson, of Detroit.
Disposable Skin Hook
Authors: Gordon Lowell
Journal: JAMA (1968)

To the Editor:—  A skin hook, constructed at the time of surgery from a disposable injection needle, has been used for the past year in the dermatology department with gratifying results (Figure).  Preparation:—  The skin hook is prepared as follows: (1) Select a needle of the appropriate size for the anticipated surgery. (2) With a special instrument, or an old hemostat, bend the needle point toward the bevel. (3) Twist bent needle on handle snugly. (4) Examine the point to be sure the metal did not break or crack. (5) Before using the instrument, test the strength of the newly made hook on a sterile cloth. This is important to insure that a small piece of metal is not lost in the surgical wound.  Advantages:—  There are seven advantages to this method: (1) A sharp hook is readily available. (2) Instrument costs are reduced. The handle is reusable. (3) The