Combination H1 and H2 Receptor Antagonist Therapy in Mastocytosis
Authors: RANDY LINDE
Journal: Annals of Internal Medicine (1980)

Letters and Corrections1 May 1980Combination H1 and H2 Receptor Antagonist Therapy in MastocytosisRANDY LINDE, M.D., HARRISON J. SHULL, M.D., SAM MARNEY, M.D., PETER W. STACPOOLE, PH.D., M.D., DAVID RABIN, M.D.RANDY LINDE, M.D.Search for more papers by this author, HARRISON J. SHULL, M.D.Search for more papers by this author, SAM MARNEY, M.D.Search for more papers by this author, PETER W. STACPOOLE, PH.D., M.D.Search for more papers by this author, DAVID RABIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-92-5-716_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Recent reports have detailed the effectiveness of H2 receptor antagonist therapy (1, 2) in the treatment of gastric hypersecretion and diarrhea in systemic mastocytosis. We report another such case in which normal bowel habits returned after treatment with H1 and H2 blocking agents, suggesting that her diarrhea was due to excessive release of mast-cell histamine.A 61-year-old white woman was admitted to Vanderbilt University Hospital in May 1978 because of profuse watery diarrhea. In January 1978, she developed continuous watery diarrhea with as many as 20 bowel movements daily. She denied flushing, headache, dizziness, or palpitations and...References1. HIRSCHOWITZ B and GROARKE J. Effect of Cimetidine on gastric hypersecretion and diarrhea in systemic mastocytosis. Ann Intern Med. 1979;90:769-71. LinkGoogle Scholar2. MCCARTHY D. Report on the United States experience with Cimetidine in Zollinger-Ellison syndrome and other hypersecretory states. Gastroenterology. 1978;74:453-8. CrossrefMedlineGoogle Scholar3. FROLICH J, BLOOMGARDEN Z, OATES J, MCGUIGAN J, and RABINOWITZ D. The carcinoid flush: provocation by pentagastrin and inhibition by somatostatin. N Engl J Med. 1978;299:1055-7. CrossrefMedlineGoogle Scholar4. MCCARTHY D, OLINGER E, MAY R, LONG B, and GARDNER J. H2-histamine receptor blocking agents in the Zollinger-Ellison syndrome. Ann Intern Med. 1976;84:211-2. MedlineGoogle Scholar5. GERRARD J and KO C. Urticaria pigmentosa: treatment with cimetidine and chlorpheniramine. J Pediatr. 1979;94:843-4. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: RANDY LINDE, M.D.; HARRISON J. SHULL, M.D.; SAM MARNEY, M.D.; PETER W. STACPOOLE, PH.D., M.D.; DAVID RABIN, M.D.Affiliations: Vanderbilt University School of Medicine and the Veterans Administration Hospital Nashville, TN 37232 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byGASTROINTESTINAL ABNORMALITIES AND INVOLVEMENT IN SYSTEMIC MASTOCYTOSISCimetidine in DermatologyComparison of the therapeutic efficacy of cromolyn sodium with that of combined chlorpheniramine and cimetidine in systemic mastocytosis. Results of a double-blind clinical trialDermatologic therapy: December, 1979, through November, 1980 1 May 1980Volume 92, Issue 5Page: 716-716KeywordsDiarrheaHabitsHeadachesHistamineMastocytosisReceptor antagonist therapySystemic mastocytosis ePublished: 1 December 2008 Issue Published: 1 May 1980 PDF downloadLoading ...