Fluorescent Antinuclear Antibodies and Anti-SS-A/Ro in Patients with Immune Thrombocytopenia Subsequently Developing Systemic Lupus Erythematosus
Authors: MICHAEL J. ANDERSON
Journal: Annals of Internal Medicine (1985)

Brief Reports1 October 1985Fluorescent Antinuclear Antibodies and Anti-SS-A/Ro in Patients with Immune Thrombocytopenia Subsequently Developing Systemic Lupus ErythematosusMICHAEL J. ANDERSON, M.D., CAROL L. PEEBLES, M.S., ROBERT McMILLAN, M.D., JOHN G. CURD, M.D.MICHAEL J. ANDERSON, M.D., CAROL L. PEEBLES, M.S., ROBERT McMILLAN, M.D., JOHN G. CURD, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-103-4-548 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA positive test for antinuclear antibodies in a patient with chronic immune thrombocytopenic purpura often presents diagnostic and therapeutic problems. Immune thrombocytopenia is the earliest clinical manifestation in a small percentage (3% to 16%) of patients who subsequently develop systemic lupus erythematosus (1, 2). Early recognition of those patients with immune thrombocytopenia who will ultimately develop more serious manifestations of systemic lupus erythematosus would allow better management of their disease.The fluorescent antinuclear antibody assay, although positive in patients with systemic lupus erythematosus, is not specific (3). The presence of autoantibodies to certain defined nuclear antigens is commonly associated with...References1. KARPATKIN S. Autoimmune thrombocytopenic purpura. Blood. 1980;56:329-43. CrossrefMedlineGoogle Scholar2. DOANBOURONCLEWISEMAN DBB. Idiopathic and secondary thrombocytopenic purpura: clinical study and evaluation of 381 cases over a period of 28 years. Ann Intern Med. 1960;53:861-76. LinkGoogle Scholar3. TANCOHENFRIES EAJ. The 1982 criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1982;25:1271-7. CrossrefMedlineGoogle Scholar4. TAN E. Autoantibodies in systemic lupus erythematosis. In: CUMMINGS NB, MICHAEL AF, WILSON CB, eds. Immune Mechanisms in Renal Disease. New York: Plenum Publishing Corporation; 1982: 489-98. Google Scholar5. NAKAMURAMOLDENTANPEEBLES RDEC. Autoantibodies to nuclear antigens (ANA). In: Advances in Laboratory Tests and Significance in Systemic Rheumatic Diseases. Chicago: American Society of Clinical Pathology; 1984. Google Scholar6. FROMMHAGEN L. The solubility and other physiochemical properties of human globulin labeled with fluorescein isothrocyantate. J Immunol. 1965;95:442-5. MedlineGoogle Scholar7. MORLEYBERNSTEINBUNN KRC. Thrombocytopenia and anti-Ro [Letter]. Lancet. 1981;2:940. CrossrefMedlineGoogle Scholar8. MADDISONMOGAVEROPROVOSTREICHLIN PHTM. The clinical significance of autoantibodies to a soluble cytoplasmic antigen in systemic lupus erythematosis and other connective tissue disorders. J Rheum. 1979;6:189-95. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: U.S. Navy Hospital, San Diego Scripps Clinic and Research Foundation La Jolla, California PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byANA-positive primary immune thrombocytopaenia: a different clinical entity with increased risk of connective tissue diseasesChildhood‐onset systemic lupus erythematosus and immune thrombocytopenia: Prevalence and risk factorsRole of antithyroid autoimmunity as a predictive biomarker of chronic immune thrombocytopeniaFeatures associated with hematologic abnormalities and their impact in patients with systemic lupus erythematosus: Data from a multiethnic Latin American cohortAutoimmunity and Novel Therapies in Immune-Mediated ThrombocytopeniaPrimäre Immunthrombozytopenie des Erwachsenen – Diagnostik und Therapie, Konsensus-Statement der Österreichischen Gesellschaft für Hämatologie und Onkologie (ÖGHO)Prevalence of Autoantibodies Related to Some Autoimmune Disorders in Patients With Chronic Idiopathic Thrombocytopenic PurpuraAntinuclear antibody (ANA)–positive thrombocytopenia: primary, but with a differenceThe ITP syndrome: pathogenic and clinical diversityA positive antinuclear antibody test predicts for a poor response to initial steroid therapy in adults with idiopathic thrombocytopenic purpuraPrevalence and clinical significance of the positive antinuclear antibody in children with idiopathic thrombocytopenic purpuraPrevalence and clinical significance of elevated antinuclear antibody test in children and adult patients with idiopathic thrombocytopenic purpuraRisk factors for future development of systemic lupus erythematosus in children with idiopathic thrombocytopenic purpuraSLE-Associated TestsANTIBODIES TO NONHISTONE ANTIGENS IN SYSTEMIC LUPUS ERYTHEMATOSUSEvidence-based guidelines for the use of immunologic tests: Antinuclear antibody testingAutoimmune thrombocytopenia in primary antiphospholipidsyndrome and systemic lupus erythematosus: The response to splenectomyGrand Rounds from International Lupus Centres A young woman with SLE: diagnostic and therapeutic challengesClinical Significance of the Antinuclear Antibody Test in Selected Children with Idiopathic Thrombocytopenic PurpuraSpecific antiplatelet autoantibodies in patients with antiphospholipid antibodies and thrombocytopeniaFamilial lupoid thrombocytopeniaCytopenias and anti-Ro (SS-A) antibodies: A report of 11 casesAntinuclear antibodies in patients with chronic idiopathic autoimmune thrombocytopenia followed 2–30 yearsBleeding Disorders in PregnantPatients with Rheumatic DiseasesLUPOID THROMBOCYTOPENIA 1 October 1985Volume 103, Issue 4Page: 548-550KeywordsAntigensAntinuclear antibodiesAutoantibodiesAutoimmune diseasesCardiovascular therapyIdiopathic thrombocytopenic purpuraLupus erythematosusSystemic lupus erythematosus Issue Published: 1 October 1985 PDF downloadLoading ...