tbuckley/cabot-search huggingface dataset:
Successful treatment of severe refractory idiopathic thrombocytopenic purpura with liposomal doxorubicin
Authors: Thomas M. Cosgriff, Marcus L. Black, William Stein
Journal: American Journal of Hematology (1998)

Idiopathic thrombocytopenic purpura (ITP) is refractory to initial treatment (steroids and splenectomy) in 25 to 30% of patients. These patients have a significant risk of fatal hemorrhage. Two patients with ITP refractory to multiple interventions and severe depression of platelet counts responded to treatment with liposomal doxorubicin with a return of platelet counts to normal. The drug is easily administered and was well tolerated. Use of this drug in refractory ITP merits further study. Am. J. Hematol. 57:85–86, 1998. © 1998 Wiley-Liss, Inc.
Gallstones and Estrogens
Authors: F. J. Ingelfinger
Journal: New England Journal of Medicine (1974)

Elsewhere in this issue, a report from the Boston Collaborative Drug Surveillance Program presents findings that are in harmony with an earlier article from the same group to the effect that women of childbearing age who used oral contraceptives appeared to be twice as likely to have gallbladder disease as women of similar age who were non-users.1 In the present survey of post-menopausal women, it was found that the estimated relative risk of those who had taken estrogens for menopausal symptoms was 2.5 times that of a control group. The validity of such correlations made by the Boston Collaborative Drug . . .
More funds needed to advance millennium development goals
Authors: J. Zarocostas
Journal: BMJ (2010)

More funds and a strong dose of political will are needed to keep advancing the millennium development goals, especially some health related goals such as improving maternal health, which is falling short of its target, advocates and experts say.

Although they lauded the progress made in the past three to four years in combating malaria, tuberculosis, and HIV/AIDS, and in lowering childhood mortality rates and fighting hunger, they cautioned that the gains are fragile. If efforts by donors and recipient governments are not sustained the gains could collapse. 

Gunilla Carlsson, Sweden’s minister of international cooperation, warned that millennium development goal 5, to reduce …
Unilateral Aciduria in Renal Artery Stenosis.
Authors: William H. Hulet
Journal: Annals of Internal Medicine (1967)

s1 May 1967Unilateral Aciduria in Renal Artery Stenosis.William H. Hulet, M.D., F.A.C.P.William H. Hulet, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-5-1037_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCurable hypertension of renal vascular origin is a disease that continues to present difficulties in diagnosis. The principal reason for these recurring problems is that the available diagnostic procedures provide only indirect evidence for a correctable renal lesion responsible for hypertension. Further refinement of our understanding of the relationship between the renin-angiotensin-aldosterone system and hypertension will undoubtedly lead to a direct means for assessing the role of a diseased kidney in hypertension. Until then, however, most physicians must rely on an anatomic and functional evaluation of the individual kidneys for the diagnosis of hypertension-producing renal lesions.Unilateral renal artery stenosis... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: William H. Hulet, M.D., F.A.C.P.Affiliations: Coral Gables, Florida PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1967Volume 66, Issue 5Page: 1037-1037KeywordsHypertensionKidneysLesionsRenal arteriesRenal diseasesStenosisVascular diseases ePublished: 1 December 2008 Issue Published: 1 May 1967 PDF downloadLoading ...
Cyclooxygenase-1–selective inhibition prolongs gestation in mice without adverse effects on the ductus arteriosus
Authors: Charles D. Loftin, Darshini B. Trivedi, Robert Langenbach
Journal: Journal of Clinical Investigation (2002)

Preterm delivery is the leading cause of neonatal mortality and contributes significantly to infant morbidity. Classical cyclooxygenase (COX) inhibitors, such as indomethacin, which inhibit both COX-1 and COX-2, are effective for delaying premature labor, but their use is limited by serious complications to the fetus and neonate, including adverse effects on the ductus arteriosus (DA). Using isoform-selective inhibitors, we characterized the roles of the COX isoforms in the initiation of labor and the regulation of fetal and neonatal DA closure in mice. Chronic inhibition of COX-2 during pregnancy (gestation days 15–18) significantly increased neonatal mortality by preventing closure of the DA after birth, whereas acute COX-2 inhibition near the end of term (gestation day 18) constricted the fetal DA. In contrast, the inhibition of COX-1 during pregnancy lacked these prenatal and postnatal adverse effects on the DA and effectively delayed the initiation of full-term labor and LPS-induced preterm labor. These findings suggest that premature fetal DA closure or neonatal patent DA observed following indomethacin tocolysis in women may result from the inhibition of COX-2. Therefore, COX-1–selective inhibitors may provide effective treatment to delay preterm labor with fewer adverse effects on fetal or neonatal health than nonselective or COX-2–selective inhibitors.
TCT-790 Prediction of long-term clinical outcome according to the etiology of mitral regurgitation in patients undergoing MitraClip therapy
Authors: Volker Rudolph, Michael Schlueter, Hermann Reichenspurner, Daniel Lubs, Edith Lubos, Britta Goldmann, Stefan Blankenberg, Stephan Baldus
Journal: Journal of the American College of Cardiology (2012)
Tc-99m TRODAT Findings in a Mercury-Exposed Worker
Authors: Chun-Yi Lin, Saou-Hsing Liou, Chun-Ming Hsiech, Cheng-Kai Huang, Song-Yen Tsai
Journal: Clinical Nuclear Medicine (2008)

A 28-year-old man at high risk of mercury vapor exposure, having worked in a lamp factory for 5 years, was recruited to the hospital for a neurologic evaluation. This experimental study obtained both the approval of Institutional Review Board and the worker's informed consent. The worker had complained of memory impairment, palpitations, and depression after working in the factory. His biologic urine mercury level was 9.18 μg/g creatinine. There was no abnormality on the brain-CT scan. However, imaging with Tc-99m TRODAT, an agent for dopamine transporter and measuring dopamine innervation of the striatum, showed markedly decreased uptake in bilateral striata especially in the putamen. Based on the worker's occupational history of mercury exposure and biologic urine mercury level, mercury exposure was confirmed.
Identification of a soluble form of a ligand for the lymphocyte homing receptor.
Authors: M Brustein, G Kraal, R E Mebius, S R Watson
Journal: The Journal of Experimental Medicine (1992)

Lymphocytes are engaged in constant trafficking from the blood into secondary lymphoid tissues, such as peripheral lymph nodes (PLN), mesenteric lymph nodes (MLN), and Peyer's patches (PP). The initial step in this process is the binding of lymphocytes to high endothelial venules (HEV), and in the case of trafficking of cells to the PLN, it is required that they bear the L-selectin surface receptor. Using a chimeric protein, combining the extracellular domains of L-selectin with a human immunoglobulin (Ig) G1 Fc region (L-selectin-IgG), we have probed the expression of ligands for this receptor on HEV and in cell lysates. Two sulfated glycoproteins of 50 and 90 kD have been identified in lysates from PLN and MLN, but not PP. Here we show that the 50-kD molecule is secreted in organ cultures in vitro and is present in the blood of normal animals. Indeed, normal serum inhibits lymphocyte binding to HEV by approximately 50% in an in vitro assay. This inhibitory activity can be removed by passage of the serum over an L-selectin-IgG column and has a molecular mass of approximately 50 kD. We speculate on the possible reasons for secretion of a homing receptor ligand.
Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer
Authors: Sakari Vanharanta, Weiping Shu, Fabienne Brenet, A. Ari Hakimi, Adriana Heguy, Agnes Viale, Victor E. Reuter, James J.-D. Hsieh, Joseph M. Scandura, Joan Massagué
Journal: Nature Medicine (2012)
Basic Endocrinology for Students of Biology and Medicine
Authors: Frederick C. Goetz
Journal: JAMA (1967)

The authors intended this book to be a brief summary of mammalian endocrinology, which can serve as an introduction to the subject for students of physiology and biochemistry. A large portion of the material presented comes from human endocrinology, but the authors wisely avoid any detailed consideration of the treatment of human endocrine disorders.  This is a good and useful student handbook which covers the classical areas of endocrinology in a well organized and concise fashion. Unfortunately, it could be considerably better than it is, without a great deal of effort from the authors. Many of the illustrations are borrowed from other sources and lack freshness. Some inaccuracies in dates and figures were easy to spot, and a few of the clinical comments could bear editing by a clinician.  The references are well chosen, and the summarizing tables of information are perhaps the strongest feature of the book.
An Advantageous Marriage
Authors: Harold C. Sox
Journal: Annals of Internal Medicine (2008)

Editorials20 May 2008An Advantageous MarriageHarold C. Sox, MD, EditorHarold C. Sox, MD, EditorSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-148-10-200805200-00013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail This issue marks the marriage of 2 publications with large and loyal readerships—Annals of Internal Medicine and ACP Journal Club. Beginning today, ACP Journal Club will appear within the second monthly issue of Annals rather than as a separate, 6-times-per-year publication.Like any good marriage, the members of this couple will retain their own unique identities. Loyal readers of ACP Journal Club will be pleased to know that its leadership remains in the hands of Brian Haynes and his team of contributing editors, who will continue to use the selection processes and summary formats that have made ACP Journal Club ... Author, Article, and Disclosure InformationAffiliations: Corresponding Author: Harold C. Sox, MD, American College of Physicians, 190 N. Independence Mall West, Philadelphia, PA 19106. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 20 May 2008Volume 148, Issue 10Page: 788KeywordsTouch ePublished: 20 May 2008 Issue Published: 20 May 2008 Copyright & PermissionsCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
The Patient-Centered Medical Home, Electronic Health Records, and Quality of Care
Authors: Lisa M. Kern, Alison Edwards, Rainu Kaushal
Journal: Annals of Internal Medicine (2014)

The patient-centered medical home (PCMH) model of primary care is being implemented widely, although its effects on quality are unclear. The PCMH typically involves electronic health records (EHRs), organizational practice change, and payment reform.To compare quality of care provided by physicians in PCMHs with that provided by physicians using paper medical records and, separately, with that provided by physicians using EHRs without the PCMH (to determine whether effects were driven by EHRs).Prospective cohort study (2008 to 2010). (ClinicalTrials.gov: NCT00793065).The Hudson Valley, a 7-county, multipayer, multiprovider region in New York.675 primary care physicians in 312 practices and 143,489 patients.Claims for 10 quality measures from the Healthcare Effectiveness Data and Information Set were used. Differences in quality were determined using generalized estimating equations adjusted for 8 physician characteristics and 4 patient characteristics.The PCMH group improved significantly more over time than either the paper group or the EHR group for 4 of the 10 measures (by 1 to 9 percentage points per measure): eye examinations and hemoglobin A1c testing for patients with diabetes, chlamydia screening, and colorectal cancer screening (adjusted P < 0.05 for each). The odds of overall quality improvement in the PCMH group were 7% higher than in the paper group and 6% higher than in the EHR group (adjusted P < 0.01 for each).This study was observational, and the possibility of unmeasured confounders cannot be excluded.The PCMH was associated with modest quality improvement. The aspects of the PCMH that drive improvement are distinct from but may be enabled by the EHR.The Commonwealth Fund and the New York State Department of Health.
Foam-Rubber Padding for Pelvic Traction Post
Authors: Irwin M. Siegel
Journal: JAMA (1966)

To the Editor:—  The degree of traction necessary to reduce and hold a broken hip on a fracture table during surgery will not uncommonly cause severe pudendal pressure at the pelvic traction post. In three instances I have noted vulvar edema and in one case a vulvar decubitus secondary to this pressure.  A simple apparatus to pad the traction post and avoid these sequelae can be fashioned with two commercial foam-rubber heel pads. When the pads are slipped over the post (Figure), an effective perineal cushion is created. Since using this method, we have encountered no further difficulty from traction post pressure.
Bile Salt Structure and Phase Equilibria in Aqueous Bile Salt and Bile Salt-Lecithin Systems
Authors: Martin C. Carey
Journal: Hepatology (1984)

The hydrophilic-hydrophobic balance of bile salt monomers can be readily quantified by their elution sequence during reverse-phase high-performance liquid chromatography. Such studies have demonstrated that subtle variations in bile salt structure have profound effects on the hydrophilic-hydrophobic balance of this important family of detergent-like molecules. The common trihydroxy bile salt, cholate, is more hydrophilic than dihydroxy bile salts with alpha-oriented OH groups. In contrast, dihydroxy bile salts with one equatorial OH function are more hydrophilic than cholate. Hydrophilic bile salts have, in general, higher critical micellar concentrations than do hydrophobic bile salts and their primary micelles polymerize less readily to form secondary micelles either with increasing bile salt concentrations or with increases in ionic strength. Hydrophilic bile salts also disperse lecithin into mixed micelles at a slower rate than do hydrophobic bile salts. The structure of mixed bile salt-lecithin micelles is more complex than previously believed and varies with bile salt-to-lecithin ratio. These micelles are disc-like in which bile salts saturate the lecithin bilayer “core” presumably as reverse micelles, as well as coating the perimeter as a bilayered “ribbon”. The ratio of bile salt to lecithin in the bilayer and the intermicellar monomeric bile salt concentration (critical micellar concentration) determines the macroscopic phase limit. With the common bile salt species, the lecithin-to-bile salt phase limit does not correlate closely with the hydrophilic-hydrophobic balance of the bile salt monomers. However, with very hydrophilic bile salts such as the pansulfated species in physiological ionic strength, the equilibria between the large intermicellar bile salt concentrations and the bile salt molecules interacting with lecithin in mixed micelles favors the former state. As a consequence, the lecithin-to-bile salt molar ratio at the phase limit is greatly reduced. However, when the charges of the sulfate groups are electrostatically shielded (e.g., in 4 MNaCl), the lecithin-to-bile salt molar ratio at the phase limit approaches and even exceeds that of the nonsulfated bile salt species.
Organ transplant improvements, demands draw increasing attention
Authors: P. Gunby
Journal: JAMA (1984)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sonnet for That Beautiful Night
Authors: Lisa June
Journal: Annals of Internal Medicine (2007)

Ad Libitum6 November 2007Sonnet for That Beautiful NightLisa June, MDLisa June, MDFrom Rheumatology Associates, Louisville, KY 40207.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-147-9-200711060-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail He goes to see his mother, still alive,her skin yellow over thinned bones, shut eyes,thankful to sleep rather than to writhe,her unvoiced dreams forcing out faint sighs.In her he sees the ebbing of such lifeas photos in an album fade to gray,snapshots of her as girl and then as wife,he wonders if this is her starring day?From her bed by which wilted flowers sit,she murmurs he “had been such a good boy.”As one of five kids, he savors this bit,a souvenir from childhood, one last toy,and he mulls over this thought, feeling proud,loving his mother in the morphine cloud. Author, Article, and Disclosure InformationAffiliations: From Rheumatology Associates, Louisville, KY 40207.Current Author Address: Lisa June, MD, Rheumatology Associates, 4213 Maryknoll Lane, Louisville, KY 40207. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 6 November 2007Volume 147, Issue 9Page: 665KeywordsBoneEmotionsMorphineRheumatologySleep ePublished: 6 November 2007 Issue Published: 6 November 2007 Copyright & PermissionsCopyright © 2007 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Eleventh Annual Science Reporters Conference Offers Cornucopia of Medical Research Stories
Authors: Andrew A. Skolnick
Journal: JAMA (1992)

A PANEL discussion on the safety of genetically engineered food products served as an "antipasto" for the American Medical Association's (AMA's) 11th annual Science Reporters Conference in Marina Del Rey, Calif. The opening discussion, which was sponsored by the National Association of Physician Broadcasters, was led by four food and nutrition experts who presented a highly palatable view of biotechnological advances in the food supply. However, not every journalist in the audience was convinced that genetically engineered agricultural products were as safe as the panel claimed. Considering how often new studies disagree with previously published scientific findings, the public has a right to doubt scientists when they claim genetically engineered foods are safe, some argued. <h3>Risks vs Benefits</h3> The panelists, Christine M. Bruhn, PhD, a consumer food marketing specialist for the University of California, Davis, Center for Consumer Research; Terry D. Etherton, PhD, professor of animal nutrition, Pennsylvania State University,
Screening for Type 2 Diabetes Mellitus: A Systematic Review for the U.S. Preventive Services Task Force
Authors: Shelley Selph, Tracy Dana, Ian Blazina, Christina Bougatsos, Hetal Patel, Roger Chou
Journal: Annals of Internal Medicine (2015)

Screening for type 2 diabetes mellitus could lead to earlier identification and treatment of asymptomatic diabetes, impaired fasting glucose (IFG), or impaired glucose tolerance (IGT), potentially resulting in improved outcomes.To update the 2008 U.S. Preventive Services Task Force review on diabetes screening in adults.Cochrane databases and MEDLINE (2007 through October 2014) and relevant studies from previous Task Force reviews.Randomized, controlled trials; controlled, observational studies; and systematic reviews.Data were abstracted by 1 investigator and checked by a second; 2 investigators independently assessed study quality.In 2 trials, screening for diabetes was associated with no 10-year mortality benefit versus no screening (hazard ratio, 1.06 [95% CI, 0.90 to 1.25]). Sixteen trials consistently found that treatment of IFG or IGT was associated with delayed progression to diabetes. Most trials of treatment of IFG or IGT found no effects on all-cause or cardiovascular mortality, although lifestyle modification was associated with decreased risk for both outcomes after 23 years in 1 trial. For screen-detected diabetes, 1 trial found no effect of an intensive multifactorial intervention on risk for all-cause or cardiovascular mortality versus standard control. In diabetes that was not specifically screen-detected, 9 systematic reviews found that intensive glucose control did not reduce risk for all-cause or cardiovascular mortality and results for intensive blood pressure control were inconsistent.The review was restricted to English-language articles, and few studies were conducted in screen-detected populations.Screening for diabetes did not improve mortality rates after 10 years of follow-up. More evidence is needed to determine the effectiveness of treatments for screen-detected diabetes. Treatment of IFG or IGT was associated with delayed progression to diabetes.Agency for Healthcare Research and Quality.
ATRIAL THROMBI DETECTION PRIOR TO PULMONARY VEIN ISOLATION: CARDIAC COMPUTER TOMOGRAPHY VERSUS TRANSESOPHAGEAL ECHOCARDIOGRAPHY
Authors: Justues Chang, Sohaib Munir, Shafeequr Salahudeen, Adrian Baranchuk, Cheryl Morris, Michael O'Reilly, Raveen S. Pal
Journal: Journal of the American College of Cardiology (2013)