Experiences in the Treatment of North American Blastomycosis with 2-Hydroxystilbamidine
Authors: WILLIAM R. LOCKWOOD
Journal: Annals of Internal Medicine (1962)

Article1 October 1962Experiences in the Treatment of North American Blastomycosis with 2-HydroxystilbamidineWILLIAM R. LOCKWOOD, M.D., JOHN F. BUSEY, M.D., BLAIR E. BATSON, M.D., FRED ALLISON JR., M.D.WILLIAM R. LOCKWOOD, M.D.Search for more papers by this author, JOHN F. BUSEY, M.D.Search for more papers by this author, BLAIR E. BATSON, M.D.Search for more papers by this author, FRED ALLISON JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-57-4-553 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe dramatic antifungal effect of stilbamidine in control of systemic blastomycosis in human beings, reported by Schoenbach, Miller, Ginsberg, and Long in 1951, represented the first substantial and effective therapy for this disease (1). Their observations were confirmed by others, but a significant incidence of peripheral neuropathy associated with use of the drug led to investigation of other, though structurally similar, agents. Shortly thereafter, 2-hydroxystilbamidine was found to exhibit similar antimycotic properties although it was less active than stilbamidine on a weight basis (2). Furthermore, 2-hydroxystilbamidine was clearly less toxic than stilbamidine and soon replaced it as the treatment of...References1. SCHOENBACHMILLERGINSBERGLONG EBJMMPH: Systemic blastomycosis treated with stilbamidine—a preliminary report. JAMA 146: 1317, 1951. CrossrefMedlineGoogle Scholar2. SNAPPERMCVAY ILO: The treatment of North American blastomycosis with 2-hydroxystilbamidine. Amer. J. Med. 15: 602, 1953. CrossrefGoogle Scholar3. HARRELLCURTIS ERAC: The treatment of North American blastomysosis with amphotericin B. Arch. Derm. 76: 561, 1957. CrossrefGoogle Scholar4. HARRELLCURTIS ERAC: North American blastomycosis. Amer. J. Med. 27: 750, 1959. CrossrefGoogle Scholar5. SEABURYDASCOMB JHHE: Experiences with amphotericin B for the treatment of systemic mycoses. Arch. Intern. Med. 102: 960, 1958. CrossrefGoogle Scholar6. ABERNATHYJANSEN RSGT: Therapy with amphotericin B in North American blastomycosis. Ann. Intern. Med. 53: 1196, 1960. LinkGoogle Scholar7. WILSON JW: Therapy of systemic fungous infections in 1961. Arch. Intern. Med. 108: 182, 1961. CrossrefGoogle Scholar8. WINDOMSANFORDPRITCHARDABERNATHYMUCHMORE REJPJARSHG: The hematotoxicity of amphotericin B. Clin. Res. 9: 47, 1961. Google Scholar9. EVANSBAKER JHRD: Treatment of experimental aspergillosis with amphotericin B. Antibiot. Chemother. (Wash.) 9: 209, 1959. MedlineGoogle Scholar10. BAUMSCHWARZ GLJ: North American blastomycosis. Amer. J. Med. Sci. 238: 661, 1959. CrossrefGoogle Scholar11. ALLISONWHITEHEADLANCASTERWOODBRIDGE FAEMGHE: Simultaneous infection by H. capsulatum and B. dermatitidis. Amer. J. Med. 32: 476, 1962. CrossrefMedlineGoogle Scholar12. MARTINSMITH DSDT: Blastomycosis. I. A review of the literature. Amer. Rev. Tuberc. 39: 275, 1939. Google Scholar13. SCHWARZBAUM JGL: Blastomycosis. Amer. J. Clin. Path. 21: 999, 1951. CrossrefMedlineGoogle Scholar14. SMITHHARRISCONANTSMITH JGJWNFDT: An epidemic of North American blastomycosis. JAMA 158: 641, 1955. CrossrefMedlineGoogle Scholar15. ABERNATHY RS: Clinical manifestations of pulmonary blastomycosis. Ann. Intern. Med. 51: 707, 1959. LinkGoogle Scholar16. LITTMANHOROWITZSWADEY MLPLJG: Coccidioidomycosis and its treatment with amphotericin B. Amer. J. Med. 24: 568, 1958. CrossrefMedlineGoogle Scholar17. SEABURY JH: Experiences with amphotericin B. Chemotherapia (Basel) 3: 81, 1961. CrossrefMedlineGoogle Scholar18. BUSEY JF: Blastomycosis cooperative study. Preliminary report of retrospective analysis of Veterans Administration cases. To be published. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Jackson, MississippiFrom the Departments of Medicine and Pediatrics, University of Mississippi Medical Center, and Jackson Veterans Administration Hospital, Jackson, Mississippi.Presented in part at the annual meeting of the Southern Society for Clinical Research, New Orleans, Louisiana, January 20, 1962.Dr. Lockwood is a Post Doctoral Fellow of the National Heart Institute, United States Public Health Service.Requests for reprints should be addressed to Fred Allison, Jr., M.D., Department of Medicine, The University of Mississippi Medical Center, 2500 North State Street, Jackson 6, Mississippi. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByClinical Application and Side Effects of Antifungal AgentsBlastomycosis in children: A review of the literatureThe spectrum of primary blastomycotic meningitis: A review of central nervous system blastomycosisAntifungal agentsNorth American BlastomycosisNorth American BlastomycosisBlastomycosis in childhood: treatment with amphotericin B and a review of the literatureAußereuropäische MykosenMycotic Infections of Interest to Thoracic SurgeonsAntimicrobial therapy in systemic fungal infectionsThe Use of Amphotericin B in Blastomycosis, Cryptococcosis and Histoplasmosis 1 October 1962Volume 57, Issue 4Page: 553-562KeywordsAntifungalsBlastomycosisDrugsHeartHospital medicineMedical servicesNauseaPediatricsPeripheral neuropathySystemic diseases Issue Published: 1 October 1962 PDF DownloadLoading ...