tbuckley/cabot-search huggingface dataset:
Serum Beta-Lipoproteins in the Preand Postmenopausal Female
Authors: Charles L. Heiskell
Journal: JAMA (1961)

A specific immunochemical technique was used for the quantitative measurement of serum beta-lipoproteins in 124 premenopausal and 248 postmenopausal women. The mean premenopausal and postmenopausal levels were 1.9 ± 0.6 and 2.5 ± 1.0 immunocrit units, respectively. There was significant correlation of serum beta-lipoprotein levels with age for the group as a whole, but this appeared to have been the result of a relatively sharp rise in the mean level at the time of the menopause. Postmenopausal patients may benefit from estrogen-replacement therapy, not only for the relief of vasomotor symptoms but also because of the possible prophylactic effects with respect to eventual development of atherosclerotic disease.
UK stillbirth rate stops declining as age of mothers rises
Authors: Owen Dyer
Journal: BMJ (2007)

The United Kingdom's stillbirth rate has stopped declining in recent years, and even current rates of perinatal mortality may be hard to maintain because the average age of British mothers continues to rise, a report from the Confidential Enquiry into Maternal and Child Health says.

The Confidential Enquiry into Maternal and Child Health is a research group mandated by the government to collect confidential statistics from NHS trusts and neonatal networks. Its latest report records stillbirths and perinatal deaths for 2005 in England, Wales, and Northern Ireland.

Slightly more than one in 200 pregnancies ended in a stillbirth, and about one …
Interleukin-5 Expression in the Bone Marrow of Sensitized Balb/c Mice after Allergen Challenge
Authors: ELEANOR M. MINSHALL, ROBERT SCHLEIMER, LISA CAMERON, MIKE MINNICOZZI, ROBERT W. EGAN, JOSE-CARLOS GUTIERREZ-RAMOS, DAVID H. EIDELMAN, QUTAYBA HAMID
Journal: American Journal of Respiratory and Critical Care Medicine (1998)

Interleukin-5 (IL-5) is a potent eosinophilopoietic factor implicated in the chronic inflammatory cell accumulation accompanying bronchial asthma. However, its role in stimulating eosinophil differentiation within the bone marrow following allergen exposure remains to be elucidated. The aims of our study were to determine the expression of IL-5 within the bone marrow of sensitized and control mice after allergen exposure, and to investigate the cellular phenotype of IL-5-producing cells. Sensitized Balb/c mice were challenged with either ovalbumin (OVA) or sterile saline. After 6 h, the mice were exsanguinated and the bone marrow prepared for cytospins. Bone marrow-derived cells from OVA-sensitized mice exhibited an increase in IL-5 immunoreactivity and mRNA compared with those from nonsensitized control mice (p < 0. 05). After allergen challenge, there was a further increase in IL-5 expression (p < 0.05) within the bone marrow. Both sensitization and allergen challenge resulted in an increase in the number of cells expressing major basic protein (MBP) (p < 0.05). In nonsensitized mice, the IL-5 mRNA was expressed predominantly by CD34-positive (CD34+) progenitor cells. Following sensitization and allergen challenge, CD3-positive (CD3+) T lymphocytes were the major source of this cytokine. These results demonstrate the presence of IL-5 within the bone marrow of normal Balb/c mice. After sensitization and allergen challenge, the increase in IL-5-producing cells within the bone marrow is attributed by T lymphocytes.
Safety and Efficacy Of Dupilumab Versus Placebo For Moderate-To-Severe Atopic Dermatitis In Patients Using Topical Corticosteroids (TCS): Greater Efficacy Observed With Concomitant Therapy Compared To TCS Alone
Authors: Diamant Thaci, Margitta Worm, Haobo Ren, Steven Weinstein, Neil Graham, Gianluca Pirozzi, Warren Brooks, Marius Ardeleanu
Journal: Journal of Allergy and Clinical Immunology (2014)
Abstract 3118: The proteasome inhibitor Bortezomib rescues clinically identified unstable missense variants of the DNA mismatch repair protein Msh2
Authors: Tim Arlow, Alison Gammie
Journal: Cancer Research (2012)

Abstract Msh2 is required for DNA mismatch repair in eukaryotes. Deleterious mutations in human MSH2 account for approximately half of the alleles associated with Hereditary Nonpolyposis Colorectal Cancer (HNPCC) or Lynch Syndrome. Previously, we characterized clinically-identified MSH2 missense mutations, using yeast as a model system and found that the most common cause of defective DNA mismatch repair was low levels of the variant Msh2 proteins. Here, we measured the half-lives of the Msh2 variants and found that increased protein turnover was responsible for the low cellular levels. Additionally, restoring levels with increased gene dosage fully restored mismatch repair function in 10 of the 21 variants in a DNA polymerase proofreading defective strain background in which mismatch repair is essential. Using immunoprecipitation, we detected high molecular weight ubiquitinated species of unstable Msh2 variants when over-expressed. Additionally, genetic and chemical inhibition of the proteasome stabilized low-level Msh2 missense variants. We identified San1, an ubiquitin ligase known to target misfolded nuclear proteins, as responsible for targeting the MSH2 missense variants. Deletion of San1 restored protein levels for all but one variant, but did not elevate wild-type Msh2 levels. Additionally, mismatch repair function was significantly improved when the Msh2 variants that had displayed high-copy restoration of function were expressed in a san1α strain. Taken together, these results indicate that the ubiquitin-mediated proteasome degradation pathway is the major mechanism for increased turnover of the clinically identified Msh2 variants. Human MutSα, comprised of Msh2 and Msh6, is also regulated by the ubiquitin-mediated pathway, underscoring the conservation of regulation as well as function for mismatch repair in eukaryotes. Additionally, it is well established that mismatch repair defective tumors are resistant to standard chemotherapeutic regimens. Of therapeutic significance, the clinically approved drug Bortezomib partially restored levels and mismatch repair function in two different msh2 missense variants. In this regard, Bortezomib may prove to be a valuable adjuvant chemotherapeutic for individuals with particular alleles of MSH2. Our results provide the foundation for an innovative therapeutic regime for certain mismatch repair defective cancers that are refractory to conventional chemotherapies. Currently we are testing the rescue phenotype in human cells. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3118. doi:1538-7445.AM2012-3118
Misfolding and interactions of Aß proteins: Insight from single molecule experiments and computational analyses
Authors: Lv Zhengjian, Yuliang Zhang, Alexey Krasnoslobodsev, Robin Roychaudhuri, Margaret Condron, David Teplow, Sandor Lovas, Luda Shlyakhtenko, Yuri Lyubchenko
Journal: Molecular Neurodegeneration (2013)

Background The current model for the development of Alzheimer’s (AD), Parkinson’s, Huntington’s, prion, and other neurodegenerative diseases involves protein misfolding as the early step followed by spontaneous aggregation, with specific proteins identified as the primary initiators for disease development. Therefore, elucidating the properties of the disease-prone misfolded states, understanding the mechanism of their formation, and identification of their most toxic forms will open prospects for the development of early diagnostics and specific therapeutics for these diseases.
Free fatty acids and arrhythmias following acute coronary artery occlusion in pigs
Authors: A. S. MOST, R. J. CAPONE, P. A. MASTROFRANCESCO
Journal: Cardiovascular Research (1977)

The arrhythmogenic potential of elevated serum free fatty acids (FFA) was investigated in closed-chest pigs following acute coronary artery occlusion. Animals both with and without ventricular irritability before the FFA rise were studied. No significant increase in PVC frequency occurred and only 1 out of 17 animals developed ventricular fibrillation in the 60 min following acute FFA elevation. In this situation, FFA did not significantly influence the appearance of arrhythmias.
AMMONIUM UPTAKE BY THE EXTREMITIES AND BRAIN IN HEPATIC COMA, 12
Authors: Leslie T. Webster, George J. Gabuzda
Journal: Journal of Clinical Investigation (1958)

disease were found to remove significant amounts of ammonium from a given volume of blood.However, in other instances they failed to do so, and thereby contributed indirectly to the increased blood ammonium concentrations observed. METHODSThree groups of patients were studied.The first con- sisted of 24 hospitalized patients without liver disease, the second of 27 patients with hepatic cirrhosis, and the third of 23 patients with hepatic cirrhosis and either impending hepatic' coma or coma.The last group is referred to subsequently as the "coma" group.Patients in the "coma" group were divided into one group with- out an added nitrogen load and a second group of pa- tients with an added nitrogen load in the form of blood in their gastrointestinal tracts (evidence of upper gastro- intestinal hemorrhage or massive epistaxis and blood swallowing).Pertinent clinical and laboratory data on all patients are presented in Tables I, II and III.Patients were observed on the wards of Cleveland City Hospital, Crile Veterans Administration Hospital, and Boston City Hospital.5Confusion, coma and "flapping" tremor were graded from first to fourth degree; first degree indicated a mild, and fourth degree a serious, disturbance for each condition as previously described (20).Estimated daily protein intakes ranged from 30 to 100 grams for patients not in the "coma" group.Pro- tein was withheld from confused or comatose patients for at least 24 and usually more than 48 hours before blood sampling.Control was instituted over most factors known to in- crease blood ammonium (NHL-N) concentrations in pa- tients with hepatic disease.No patient received am- monium salts within 72 hours of blood sampling.Blood samples were obtained only when patients had not re- ceived nitrogenous foods for the preceding 12 hours (13).Active gastrointestinal bleeding and epistaxis (15) were absent in all patients except some in the "coma" group.Because urea given intravenously may cause prompt in- creases in blood NH4-N concentrations (13), patients 4Characterized by mental confusion and a "flapping" tremor (19). 5Five patients in the " coma" group were studied at Boston City Hospital.Six patients in the cirrhosis group and one in the " coma" group were observed at Crile Veterans Administration Hospital in Cleveland.
Nutrition in General Practice: Giving Advice to Women
Authors: Neva L. Crogan
Journal: Annals of Internal Medicine (1998)

Medical Writings1 July 1998Nutrition in General Practice: Giving Advice to WomenNeva L. Crogan, MN, RN, CSNeva L. Crogan, MN, RN, CSWashington State University, Mead, Washington.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-129-1-199807010-00030 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Nutrition in General Practice: Giving Advice to Women; Seabrook N. 202 pages. Boston: Butterworth-Heinemann; 1997. $35.00. ISBN 0750634642. Order phone 800-366-2665.Field of medicine: Women's health.Format: Softcover book.Audience: Primary care physicians, nurse practitioners, health science students, and dietitians.Purpose: To bring together, in one publication, information on dietary interventions that can be used by health care practitioners treating or counseling women.Content: This is a good resource manual for health care practitioners who give dietary advice to women. It contains information on the role of nutrition in the prevention of chronic conditions and the treatment of acute conditions, ... Author, Article, and Disclosure InformationAuthors: Neva L. Crogan, MN, RN, CSAffiliations: Washington State University, Mead, Washington. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1998Volume 129, Issue 1Page: 79KeywordsHealth careNursesNutritionObesityObstetrics and gynecologyOsteoporosisPregnancyPremenstrual syndromePrimary carePrimary care physicians ePublished: 15 August 2000 Issue Published: 1 July 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Exploring Causes of Paralysis in Spina Bifida
Authors: Charles Marwick
Journal: JAMA (1989)

AN UNUSUAL CASE of spina bifida has set two neurosurgeons on a road that may eventually lead to a better understanding of events that cause the paralysis in this condition. About 3 years ago, pediatric neurosurgeon Dan S. Heffez, MD, repaired a myelomeningocele in a 6-month-old infant. "In this particular case the typical malformed spinal cord seen in classic spina bifida was present but the cord, instead of being exposed, was covered by a full thickness of skin," he says. "This is very unusual," Heffez points out. "It's only been reported once or twice before." "But what was most important about this case was that there was no paralysis. So here was a patient with half the characteristics of a myelomeningocele; that is, the cord was structurally malformed and was outside the spinal column but—since it was fully covered by skin—it had not been exposed to the intrauterine environment." Spina
PREDICTORS OF POOR RENAL FUNCTION AFTER CARDIAC SURGERY: ROLE OF ACE INHIBITORS
Authors: Haroon Chughtai, Kirit C. Patel, Muzammil Musani, Muhammed Janjua, Maryam Qadir, John F. Cotant, Usman Master, Michele Degregorio, Abdul R. Halabi
Journal: Journal of the American College of Cardiology (2011)
Treating Small Hepatocellular Carcinomas
Authors: Roger Williams, Paolo Rizzi
Journal: New England Journal of Medicine (1996)

Many factors influence the survival of patients with hepatocellular carcinoma, quite apart from treatment, the most important being the size of the tumor at the time of diagnosis and the severity of the underlying cirrhosis.1 Small hepatocellular carcinomas have relatively long tumor-doubling times, as compared with large, symptomatic hepatocellular carcinomas. In a recent study, the three-year survival rate among 260 patients with well-compensated cirrhosis and hepatocellular carcinomas 5 cm or less in diameter was 79 percent with surgical treatment and 26 percent without treatment; among 131 patients with more advanced liver disease, the comparable rates were 40 percent and 13 . . .
Incidence of Leukemia, Lymphoma, and Multiple Myeloma in Czech Uranium Miners: A Case–Cohort Study
Authors: Vladimír Řeřicha, Michal Kulich, Robert Řeřicha, David L. Shore, Dale P. Sandler
Journal: Environmental Health Perspectives (2006)

Uranium miners are chronically exposed to low levels of radon and its progeny. We investigated whether radon exposure is associated with increased incidence of leukemia, lymphoma, or multiple myeloma in this population.We conducted a retrospective case-cohort study in 23,043 uranium miners and identified a total of 177 incident cases of leukemia, lymphoma, and myeloma. Detailed information on occupational radon exposure was obtained for the cases and a randomly selected subcohort of 2,393 subjects. We used the proportional hazards model with power relative risk (RR) function to estimate and test the effects of cumulative radon exposures on incidence rates.Incidence of all leukemia combined and chronic lymphocytic leukemia (CLL) alone was positively associated with cumulative radon exposure. The RR comparing high radon exposure [110 working level months (WLM) ; 80th percentile] to low radon exposure (3 WLM ; 20th percentile) was 1.75 [95% confidence interval (CI) , 1.10-2.78 ; p = 0.014] for all leukemia combined and 1.98 (95% CI, 1.10-3.59 ; p = 0.016) for CLL. Myeloid leukemia and Hodgkin lymphoma were also associated with radon, but RRs were not statistically significant. There was no apparent association of radon with either non-Hodgkin lymphoma or multiple myeloma. Exposure to radon and its progeny was associated with an increased risk of developing leukemia in underground uranium miners. CLL, not previously believed to be radiogenic, was linked to radon exposure.
Glucocorticoid Receptors: ATP and Cell Cycle Dependence, Phosphorylation, and Hormone Resistance
Authors: Jack E. Bodwell, Jiong-Ming Hu, Li-Ming Hu, Allan Munck
Journal: American Journal of Respiratory and Critical Care Medicine (1996)

"Glucocorticoid Receptors: ATP and Cell Cycle Dependence, Phosphorylation, and Hormone Resistance." American Journal of Respiratory and Critical Care Medicine, 154(2_pt_2), pp. S2–S6
Clonal mast cell disorders in patients with systemic reactions to Hymenoptera stings and increased serum tryptase levels
Authors: Patrizia Bonadonna, Omar Perbellini, Giovanni Passalacqua, Beatrice Caruso, Sabrina Colarossi, Daniela Dal Fior, Luca Castellani, Chiara Bonetto, Francesco Frattini, Annarita Dama, Giovanni Martinelli, Marco Chilosi, Gianenrico Senna, Giovanni Pizzolo, Roberta Zanotti
Journal: Journal of Allergy and Clinical Immunology (2009)
Synchronization and recruitment in acute leukemia
Authors: Beatrice C. Lampkin, Takeshi Nagao, Alvin M. Mauer
Journal: Journal of Clinical Investigation (1971)

The in vivo effects of several chemotherapeutic agents on the mitotic cycle of leukemic blasts in the bone marrow were evaluated by serial measurements of cells in mitosis and in deoxyribonucleic acid (DNA) synthesis as indicated by ability to incorporate tritiated thymidine or tritiated deoxyuridine. 28 studies were done in 23 children and 1 adult. The changes in the marrow after a single injection of L-asparaginase, hydrocortisone, cyclophosphamide, cytosine arabinoside, methotrexate, and an exchange transfusion (62% of the total blood volume) were evaluated. L-asparaginase and hydrocortisone were found to arrest the entry of cells into the S period. Cyclophosphamide appeared to inhibit DNA synthesis, arrest cells in mitosis, and inhibit the entry of cells into the S period. Cytosine arabinoside, and methotrexate inhibited DNA synthesis. During the period of time the cells were inhibited in the S phase by these two drugs, cells continued to enter the S period. Thus partial synchronization was achieved after these two drugs. An exchange transfusion had no consistent effect on the mitotic cycle, but partial synchronization in the S period was seen in one patient. To take advantage of the ability of cystosine arabinoside, to synchronize leukemic cells in the S phase, a second cycle-dependent drug was given at the time the leukemic blasts were synchronized. The second cycle-dependent drugs evaluated were vincristine, methotrexate, and cytosine arabinoside given by intravenous drip over a 12 hr period. Recruitment was found after cytosine arabinoside alone, and after prior synchronization with cytosine arabinoside and then the administration of either of these drugs. The results of these studies indicate that a greater therapeutic advantage can be achieved by a second cycle-dependent drug after synchronization than after the second drug alone.
Cardiac angiography without cine film: Erecting a “Tower of Babel” in the cardiac catheterization laboratory
Authors: Steven E. Nissen, Carl J. Pepine, Thomas M. Bashore, Peter C. Block, Lawrence I. Bonchek, Jeffrey A. Brinker, Blase Carabello, John S. Douglas, Jonathan L. Elion, John W. Hirshfeld, David R. Holmes, Warren L. Johnson, W.Peter Klinke, David C. Levin, G.B.John Mancini, Charles E. Mullins, James D. Thomas, Eric J. Topol, John H.K. Vogel, Merrill A. Wondrow
Journal: Journal of the American College of Cardiology (1994)
High Levels of Systemic Myeloperoxidase Are Associated With Coronary Plaque Erosion in Patients With Acute Coronary Syndromes
Authors: Giuseppe Ferrante, Masataka Nakano, Francesco Prati, Giampaolo Niccoli, Maria T. Mallus, Vito Ramazzotti, Rocco A. Montone, Frank D. Kolodgie, Renu Virmani, Filippo Crea
Journal: Circulation (2010)

Background— Systemic levels of myeloperoxidase predict prognosis in patients with acute coronary syndromes and are considered a marker of plaque vulnerability. It is not known whether myeloperoxidase is associated with different coronary morphologies (ie, rupture or erosion of the culprit lesion) in patients with acute coronary syndrome. Methods and Results— Twenty-five consecutive patients (aged 67±11 years; 15 men [60%]; 13 [52%] with non–ST-segment elevation acute coronary syndrome and 12 [48%] with acute ST-segment elevation myocardial infarction) were enrolled. Optical coherence tomography classified the culprit lesion as ruptured in 18 (72%) or eroded in 7 patients (28%) and detected intraluminal thrombus in 89% of ruptured plaques and 100% of eroded plaques. Baseline systemic levels of serum myeloperoxidase were significantly higher in patients with an eroded plaque than in those with a ruptured plaque (median, 2500 ng/mL; 25th to 75th percentile, 1415 to 2920 versus median, 707 ng/mL; 25th to 75th percentile, 312 to 943; P =0.001), whereas C-reactive protein levels did not differ significantly (median, 11.3 mg/L; 25th to 75th percentile, 1.3 to 28.5 versus median, 3.9 mg/L; 25th to 75th percentile, 1.3 to 17.8; P =0.76, respectively). In addition, the density of myeloperoxidase-positive cells within thrombi overlying plaques in postmortem coronary specimens retrieved from sudden coronary death victims was significantly higher in lesions with erosion (n=11) than ruptures (n=11) (median, 1584; 25th to 75th percentile, 1088 to 2135 cells/mm 2 versus median, 579; 25th to 75th percentile, 442 to 760 cells/mm 2 ; P =0.0012). Conclusions— Systemic myeloperoxidase levels are significantly elevated in patients with acute coronary syndrome presenting with eroded culprit plaque compared with patients presenting with ruptured culprit plaque. Consistently, in postmortem coronary specimens, luminal thrombi superimposed on eroded plaques contain a higher density of myeloperoxidase-positive cells than thrombi superimposed on ruptured plaques. This study supports the concept that elevations in selective inflammatory biomarkers reflect specific acute complications of coronary atherosclerosis.
Exacerbation of pemphigus by rifampicin
Authors: S. MIYAGAWA, Y. YAMASHINA, T. OKUCHI, Y. KONOIKE, T. KANO, K. SAKAMOTO
Journal: British Journal of Dermatology (1986)

Rifampicin therapy caused exacerbation of skin lesions, rising serum pemphigus antibody titres, and decreased serum betamethasone levels in a 59-year-old man with pemphigus vulgaris. Exacerbation of pemphigus was confined to the period of rifampicin therapy and seems to be best explained by the effect of rifampicin on the metabolism of betamethasone. Physicians prescribing rifampicin for the treatment of tuberculosis should be aware of its potential to produce such an important adverse reaction.
REMARKS on a CASE of HORSESHOE KIDNEY SIMULATING MALIGNANT DISEASE of the ABDOMEN
Authors: T. Oliver
Journal: BMJ (1898)

euchinin gr.xv once a day.On October 30th he returned to me to report that he had had no fever after the second dose.He said that he was taking a supply of ouchinin back to Cayenne with him.He had some tinnitus, but not much.CASB v.-November 8th, 1897.Rev. , European, had tertian ague.He was ordered euchinin gr.xv once a day.The fever left after first dose, and did not return.He found it 'stronger" than quinine, and said that half the dose was sufficient to keep away ague, while even that caused noises in the ears.