Effects of Excessive Fructose Intake on Health
Authors: John L. Sievenpiper, Russell J. de Souza, David J.A. Jenkins
Journal: Annals of Internal Medicine (2012)

Letters19 June 2012Effects of Excessive Fructose Intake on HealthJohn L. Sievenpiper, MD, PhD, Russell J. de Souza, ScD, RD, and David J.A. Jenkins, MD, PhD, DScJohn L. Sievenpiper, MD, PhDFrom McMaster University, Hamilton, Ontario L8N 3Z5, Canada, and University of Toronto, Toronto, Ontario M5S 3E2, Canada.Search for more papers by this author, Russell J. de Souza, ScD, RDFrom McMaster University, Hamilton, Ontario L8N 3Z5, Canada, and University of Toronto, Toronto, Ontario M5S 3E2, Canada.Search for more papers by this author, and David J.A. Jenkins, MD, PhD, DScFrom McMaster University, Hamilton, Ontario L8N 3Z5, Canada, and University of Toronto, Toronto, Ontario M5S 3E2, Canada.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-156-12-201206190-00025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We thank Dr. Johnson and colleagues for their comments. Their concern was that people may infer from our data that fructose intake does not promote weight gain. On the contrary, in hypercaloric trials, extreme fructose doses providing excess energy did promote weight gain despite short follow-up; however, energy was a more important factor than substrate. The weight gain was similar to that predicted from excess energy alone. We also found no effect on body weight under the same conditions of excess energy except where the comparisons were isocalorically matched. The level of energy control was unlikely to play ...References1. Sievenpiper JL, Carleton AJ, Chatha S, Jiang HY, de Souza RJ, Beyene J, et al. Heterogeneous effects of fructose on blood lipids in individuals with type 2 diabetes: systematic review and meta-analysis of experimental trials in humans. Diabetes Care. 2009;32:1930-7. [PMID: 19592634] CrossrefMedlineGoogle Scholar2. Ha V, Sievenpiper JL, de Souza RJ, Chiavaroli L, Wang DD, Cozma AI, et al. Effect of fructose on blood pressure: a systematic review and meta-analysis of controlled feeding trials. Hypertension. 2012;59:787-95. [PMID: 22331380] CrossrefMedlineGoogle Scholar3. Wang DD, Sievenpiper JL, de Souza RJ, Chiavaroli L, Ha V, Cozma AI, et al. The effects of fructose intake on serum uric acid vary among controlled dietary trials. J Nutr. 2012;142:916-23. [PMID: 22457397] CrossrefMedlineGoogle Scholar4. Cozma AI, Sievenpiper JL, de Souza RJ, Chiavaroli L, Ha V, Wang DD, et al. Effect of fructose on glycemic control in diabetes: a meta-analysis of controlled feeding trials, Diabetes Care. 2012. [Forthcoming]. Google Scholar5. Livesey G, Taylor R. Fructose consumption and consequences for glycation, plasma triacylglycerol, and body weight: meta-analyses and meta-regression models of intervention studies. Am J Clin Nutr. 2008;88:1419-37. [PMID: 18996880] MedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: John L. Sievenpiper, MD, PhD; Russell J. de Souza, ScD, RD; David J.A. Jenkins, MD, PhD, DScAffiliations: From McMaster University, Hamilton, Ontario L8N 3Z5, Canada, and University of Toronto, Toronto, Ontario M5S 3E2, Canada.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M11-1669. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoEffect of Fructose on Body Weight in Controlled Feeding Trials John L. Sievenpiper , Russell J. de Souza , Arash Mirrahimi , Matthew E. Yu , Amanda J. Carleton , Joseph Beyene , Laura Chiavaroli , Marco Di Buono , Alexandra L. Jenkins , Lawrence A. Leiter , Thomas M.S. Wolever , Cyril W.C. Kendall , and David J.A. Jenkins Effects of Excessive Fructose Intake on Health Richard J. Johnson , Miguel A. Lanaspa , Carlos Roncal-Jimenez , and Laura G. Sanchez-Lozada Metrics 19 June 2012Volume 156, Issue 12Page: 905-906KeywordsBlood pressureBody weightFatty liverFructosesInsulin resistanceLipidsSucroseSystematic reviewsUric acidWeight gain ePublished: 19 June 2012 Issue Published: 19 June 2012 Copyright & PermissionsCopyright © 2012 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...