tbuckley/cabot-search huggingface dataset:
The Risk of AIDS After Hepatitis Vaccination
Authors: Mark J. Upfal
Journal: JAMA (1985)

To the Editor.—  In the recent decision analysis article by Sacks et al 1 in the Dec 28, 1984, issue ofThe Journal, the authors claim to have calculated the maximum rate of hepatitis B vaccine-induced acquired immunodeficiency syndrome (AIDS) to be eight per 100,000 with 95% confidence. This calculation is based on a study of 40,000 persons who had been vaccinated prior to mid-1982. I do not believe that an extrapolation from this population can be expected to hold true for a vaccine manufactured from today's pool of donors. As of June 1982, there were less than 600 reported cases of AIDS in the United States, 2 plus an unknown population of carriers of the disease-inducing agent. As of November 1984, the number of reported cases increased more than tenfold to 6,993, 3 and the number of carriers, still unknown, can be presumed to have increased as well. The
Time course of bronchoconstrictive response in asthmatic subjects to reduced temperature.
Authors: J M Ramsey
Journal: Thorax (1977)

Thirteen young adults with bronchial asthma and a like number of controls were subjected for 45 minutes to a temperature of 2 degrees C after leaving a temperature of 24 degrees C to which they subsequently returned. Pre-exposure examination included VC, FEV1, MMEF, FEV1/VC%, and urinary catecholamines. The pulmonary measurements were repeated at 15, 80, and 200 minutes after exposure. Catecholamines were measured from a second urine sample, the collection of which corresponded to the period during and after the stress. Controls showed no significant pulmonary changes throughout the time of study, but 15 minutes after exposure the asthmatic subjects showed a significant mean decrease of all pulmonary measurements from pre-exposure values. The controls showed a significant mean increase in urinary catecholamines after the stress, whereas those with asthma showed no significant increase.
Successful treatment of subacute cutaneous lupus erythematosus with mycophenolate mofetil
Authors: S. Schanz, A. Ulmer, G. Rassner, G. Fierlbeck
Journal: British Journal of Dermatology (2002)

Journal Article Successful treatment of subacute cutaneous lupus erythematosus with mycophenolate mofetil Get access S. Schanz, S. Schanz Department of Dermatology, University of Tübingen, Liebermeisterstraße 25, D‐72076 Tübingen, Germany Search for other works by this author on: Oxford Academic Google Scholar A. Ulmer, A. Ulmer Department of Dermatology, University of Tübingen, Liebermeisterstraße 25, D‐72076 Tübingen, Germany Search for other works by this author on: Oxford Academic Google Scholar G. Rassner, G. Rassner Department of Dermatology, University of Tübingen, Liebermeisterstraße 25, D‐72076 Tübingen, Germany Search for other works by this author on: Oxford Academic Google Scholar G. Fierlbeck G. Fierlbeck Department of Dermatology, University of Tübingen, Liebermeisterstraße 25, D‐72076 Tübingen, Germany Prof Dr Gerhard Fierlbeck. E‐mail: gerhard.fierlbeck@med.uni‐tuebingen.de Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 147, Issue 1, 1 July 2002, Pages 174–178, https://doi.org/10.1046/j.1365-2133.2002.04875.x Published: 01 July 2002 Article history Accepted: 14 March 2002 Published: 01 July 2002
EZH2 Promotes Expansion of Breast Tumor Initiating Cells through Activation of RAF1-β-Catenin Signaling
Authors: Chun-Ju Chang, Jer-Yen Yang, Weiya Xia, Chun-Te Chen, Xiaoming Xie, Chi-Hong Chao, Wendy A. Woodward, Jung-Mao Hsu, Gabriel N. Hortobagyi, Mien-Chie Hung
Journal: Cancer Cell (2011)
Indirect allorecognition of platelets by T helper cells during platelet transfusions correlates with anti-major histocompatibility complex antibody and cytotoxic T lymphocyte formation [published erratum appears in Blood 1995 Dec 15;86(12):4710]
Authors: JW Semple, ER Speck, YP Milev, V Blanchette, J Freedman
Journal: Blood (1995)
Retrieval of a migrated Polyflex stent – a novel technique
Authors: A. Dinani, R. Cortes, S. Sridhara, S. Reichert, K. Somnay
Journal: Endoscopy (2009)

A 77-year-old woman with cholangitis underwent endoscopic retrograde cholangiopancreatography (ERCP), sphincterectomy, and placement of a stent (CLSO-10-7; Cook Medical Inc., Bloomington, Indiana, USA) in the common bile duct.
Randomised study of effect of different doses of vitamin A on childhood morbidity and mortality
Authors: Christine Stabell Benn, Cesario Martins, Amabelia Rodrigues, Henrik Jensen, Ida Maria Lisse, Peter Aaby
Journal: BMJ (2005)

<h3>Abstract</h3> <b>Objectives</b> To determine whether the dose of vitamin A currently recommended by the World Health Organization or half this dose gives better protection against childhood morbidity and mortality. <b>Design</b> Randomised study. <b>Setting</b> A combined oral polio vaccine and vitamin A supplementation campaign in Guinea-Bissau, Africa. <b>Participants</b> 4983 children aged 6 months to 5 years. <b>Interventions</b> One of two doses of vitamin A (recommended and half); oral polio vaccine. <b>Main outcome measures</b> Mortality and morbidity at six and nine months. <b>Results</b> Mortality was lower in the children who took half the recommended dose of vitamin A compared with the full dose at both six months (mortality rate ratio 0.69, 95% confidence interval 0.36 to 1.35) and nine months (0.62, 0.36 to 1.06) of follow-up. There was a significant interaction between sex and dose, the lower dose being associated with significantly reduced mortality in girls (0.19, 0.06 to 0.66) but not in boys (1.98, 0.74 to 5.29). The lower dose of vitamin A was consistently associated with lower hospital case fatality in girls (0.19, 0.02 to 1.45). Paradoxically, in children aged 6-18 months, the low dose was associated with slightly higher morbidity. <b>Conclusions</b> Half the dose of vitamin A currently recommended by WHO may provide equally good or better protection against mortality but not against morbidity.
Prevention of acute graft-versus-host disease by blocking T-cell entry to secondary lymphoid organs
Authors: Andreas Beilhack, Stephan Schulz, Jeanette Baker, Georg F. Beilhack, Ryosei Nishimura, Enosh M. Baker, Gilad Landan, Edward I. Herman, Eugene C. Butcher, Christopher H. Contag, Robert S. Negrin
Journal: Blood (2007)
Association of both Langerhans cell histiocytosis and Erdheim-Chester disease linked to the BRAFV600E mutation
Authors: Baptiste Hervier, Julien Haroche, Laurent Arnaud, Frédéric Charlotte, Jean Donadieu, Antoine Néel, François Lifermann, Carles Villabona, Bruno Graffin, Olivier Hermine, Aude Rigolet, Camille Roubille, Eric Hachulla, Thierry Carmoi, Maud Bézier, Véronique Meignin, Marie Conrad, Laurence Marie, Elise Kostrzewa, Jean-Marie Michot, Stéphane Barete, Valerie Taly, Karine Cury, Jean-François Emile, Zahir Amoura
Journal: Blood (2014)
Carcinogenicity of malaria and of some polyomaviruses
Authors: Véronique Bouvard, Robert A Baan, Yann Grosse, Béatrice Lauby-Secretan, Fatiha El Ghissassi, Lamia Benbrahim-Tallaa, Neela Guha, Kurt Straif
Journal: The Lancet Oncology (2012)
Alternate-Day Steroid Therapy
Authors: JEFFREY T. KESSLER
Journal: Annals of Internal Medicine (1975)

Comments and Correction1 November 1975Alternate-Day Steroid TherapyJEFFREY T. KESSLER, M.D.JEFFREY T. KESSLER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-83-5-734_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The study of Hunder and colleagues (Ann Intern Med 82:613-618, 1975) showed daily administration of corticosteroids to be superior to an alternate-day regimen in the initial management of giant cell arteritis. However, it may be premature to totally discard the concept of alternate-day steroid therapy in this disease, for two reasons.First, some patients in the alternate-day nonresponder group apparently derived significant benefit on the days that they received steroids, since "typically, the patients receiving alternate-day therapy who did not respond completely felt reasonably well during some portion of the day on which 90 mg of prednisone...References1. SEYBOLDDRACHMAN MD: Gradually increasing doses of prednisone in myasthenia gravis. N Engl J Med 290:81-84, 1974 CrossrefMedlineGoogle Scholar2. FAUCHALDRYGVOLDØYSTESE POB: Temporal arteritis and polymyalgia rheumatica. Clinical and biopsy findings. Ann Intern Med 77:845-852, 1972 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Neurosciences College of Medicine and Dentistry of New Jersey New Jersey Medical School Newark, New Jersey 07103 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1975Volume 83, Issue 5Page: 734-734KeywordsGiant cellsSteroid therapy ePublished: 1 December 2008 Issue Published: 1 November 1975 PDF downloadLoading ...
Skewing Towards Neuroendocrine Phenotype in High Grade or High Stage Androgen-Responsive Primary Prostate Cancer
Authors: Luca Puccetti, Claudiu T. Supuran, Pier P. Fasolo, Enrico Conti, Giancarlo Sebastiani, Sergio Lacquaniti, Roberto Mandras, Maria G. Milazzo, Natalia Dogliani, Paolo De Giuli, Giuseppe Fasolis
Journal: European Urology (2005)
Dermatomyositis sine myositis presenting with calcinosis universalis
Authors: None Olhoffer, None Carroll, None Watsky
Journal: British Journal of Dermatology (1999)

Journal Article Dermatomyositis sine myositis presenting with calcinosis universalis Get access I.H. Olhoffer, I.H. Olhoffer Department of Dermatology, Yale University School of Medicine, 333 Cedar Street, PO Box 208059, New Haven, CT 06520‐8059, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar C. Carroll, C. Carroll Department of Dermatology, Yale University School of Medicine, 333 Cedar Street, PO Box 208059, New Haven, CT 06520‐8059, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar K. Watsky K. Watsky Department of Dermatology, Yale University School of Medicine, 333 Cedar Street, PO Box 208059, New Haven, CT 06520‐8059, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 141, Issue 2, 1 August 1999, Pages 365–366, https://doi.org/10.1046/j.1365-2133.1999.03005.x Published: 01 August 1999
The nature of concussion: a speculative hypothesis
Authors: Paul McCrory
Journal: British Journal of Sports Medicine (2001)

The nature of concussion: a speculative hypothesis Concussion is one of the commonest forms of neurological injury seen throughout the world.Although common in sport, this condition has parallels in the types of injury suffered in motor vehicle crashes, falls, and other forms of brain trauma. 1 Despite the fact that the eVects of brain injuries have been recognised for at least 3000 years and the clinical state of concussion initially described over 1000 years ago, 2 the understanding of the pathophysiology of these injuries remains limited.One issue that remains difficult to reconcile is the absence of consistent neuroimaging abnormalities in the face of dramatic symptoms.This may in part be because concussion is due to a functional rather than structural lesion but also that the anatomical locus may be not cortical as is often assumed. Clinical featuresThe acute symptoms of concussion are described in detail in many published studies.4][5][6][7] The attentional deficit is often loosely described by clinicians as "confusion" or "disorientation".While these terms are often seen as sine qua non of concussion, it is more scientifically appropriate to use the correct terminology.Other recently documented clinical features of acute concussion include convulsive and motor phenomena. 8ost of these symptoms are protean and non-specific in terms of cerebral localisation.The only symptom complex that is more likely to represent cortical or subcortical dysfunction is memory disturbance.Traditional neurological thinking would suggest that the anatomical locus for such symptoms should be in the temporal lobes or orbitotemporal region.www.bjsportmed.com
POSTURAL STABILITY DURING THE TRANSITION FROM DOUBLE-LEG STANCE TO SINGLE-LEG STANCE IN ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTED SUBJECTS
Authors: B Dingenen, L Janssens, S Claes, J Bellemans, F Staes
Journal: British Journal of Sports Medicine (2014)

Background Despite recent advances in rehabilitation and secondary prevention strategies after anterior cruciate ligament reconstruction (ACLR), re-injury rates remain high and long-term outcomes are often disappointing. Deficits in postural stability are shown to be important. Objective To evaluate postural stability during the transition from double-leg stance to single-leg stance in ACLR and non-injured control subjects. Design Cross-sectional (retrospective). Setting Controlled laboratory study. Participants 20 ACLR subjects (15 females, 5 males), 23.1±13.9 months after ACLR and fully returned to their pre-injury sport, and 20 non-injured control subjects (15 females, 5 males) participated in the study. Both groups were matched for age, gender, weight, height and activity level. All ACL injuries were caused by a non-contact injury mechanism. Risk factor assessment A transition task from double-leg stance to single-leg stance with eyes closed was performed while standing on a single force plate. Movement speed was standardized. Both legs of each subject were tested. Main outcome measurements Spatiotemporal center of pressure outcomes were compared between groups and between legs within the same group. Significance was set at P&lt;.05. Results The ACLR group showed a significant increased postural sway after the new stability point during single-leg stance (P=.005). No significant different postural stability outcomes were found between legs in both groups (P&gt;.05). Conclusions Despite the full return to sport, ACLR subjects showed a decreased ability to overcome the postural perturbation created by the transitional movement. These postural stability deficits may leave the lower extremity more vulnerable to ACL re-injury and/or other long-term problems after ACLR. Whether these deficits are a result or a pre-existing risk factor of the initial ACL injury remains unclear. The lack of bilateral differences in the ACLR group may imply that secondary prevention strategies should not only focus on the ACLR leg, but also on the non-ACLR leg.
Relationship Between Parental Trinucleotide GCT Repeat Length and Severity of Myotonic Dystrophy in Offspring
Authors: Joy B. Redman
Journal: JAMA (1993)

To assess the relationship between the GCT repeat number in the myotonic dystrophy gene and the clinical phenotype and examine its predictive utility in prenatal testing.DNA from patients was examined for the length of the myotonic dystrophy GCT repeat region, using both Southern blot analysis and polymerase chain reaction. The results were compared with the clinical onset of disease, as well as with pregnancy outcomes.Patient samples were referred to the Kleberg DNA Diagnostic Laboratory at the Baylor College of Medicine for DNA analysis by geneticists and genetic counselors (84%), neurologists (10%), and obstetricians and other specialists (6%). Clinical features including onset of disease and family pedigrees were determined by the referring centers.A total of 241 patient samples from 118 families referred from primarily genetic or neurological centers for genetic linkage analysis or mutation analysis for myotonic dystrophy. This included 44 families referred for prenatal diagnosis.A relationship between myotonic dystrophy disease onset and length of the GCT repeat allele, parental origin of the disease allele, and results of prenatal diagnosis predictions of disease status were measured.There is a relationship between increasing repeat length and earlier clinical onset of disease. Essentially all (> 99%) myotonic mutations causing myotonic dystrophy are accounted for by GCT repeat amplification. Congenital myotonic dystrophy occurs with as few as 730 GCT repeats but only with alleles of maternal origin. Maternal GCT repeats were found as low as 75 (asymptomatic) that were amplified to result in a child with congenital myotonic dystrophy. Application of DNA diagnosis to 32 pregnancies provided an accurate method for identification of at-risk fetuses and allele enlargement.The GCT repeat in myotonic dystrophy is highly mutable. The triplet repeat amplification is highly specific for mutations involving the myotonin protein kinase gene accounting for myotonic dystrophy. The quantitation of triplet repeats can be more sensitive than physical, ophthalmologic, and electromyography examinations since the mutation can be detected in patients without evidence of myotonic dystrophy clinical findings. The length of the triplet expansion is influenced by the sex of the transmitting parent and is related to the clinical onset of disease features. Prenatal measurement of the GCT triplet repeat has utility for families with myotonic dystrophy risk since mutant and normal repeats are distinguishable and the length of mutant repeat alleles is associated with clinical severity. Thus, GCT triplet measurement provides a highly accurate means of detecting the myotonic dystrophy mutation in patients and offers a new reproductive option for families at risk for myotonic dystrophy.
RETRACTED: FoxP3 Acts as a Cotranscription Factor with STAT3 in Tumor-Induced Regulatory T Cells
Authors: Dewan Md Sakib Hossain, Abir K. Panda, Argha Manna, Suchismita Mohanty, Pushpak Bhattacharjee, Sankar Bhattacharyya, Taniya Saha, Sreeparna Chakraborty, Rajiv K. Kar, Tanya Das, Subhrangsu Chatterjee, Gaurisankar Sa
Journal: Immunity (2013)
Psychiatric Consultation in the Workplace
Authors: Burton C. Einspruch
Journal: JAMA (1994)

I keenly anticipated reading Dr Len Sperry's<i>Psychiatric Consultation in the Workplace</i>. I was prompted by his extensive experience as a psychiatrist working with large corporations, his frequent publications, and the growing demand for such consultation. Sperry's work is a useful guide, especially now when many psychiatrists, attempting to balance their clinical schedules during a decline in demand for typical services, seek alternative roles. Workplace psychiatry includes most of the functions performed by psychiatrists, but in the work setting they deal not with individual family systems but with the stresses of larger systems in the workplace. Consultations also differ because most workplaces are directed primarily toward making money. Hence, humans, with all their foibles, operating under psychological drives toward pleasure, physiological drives toward rest, and various character structures, face with different degrees of success the requirements of productive work. It is incorrect to repeat the cliché that most people love
Sweeping changes are needed to boost research in India, say researchers
Authors: Priyanka Pulla
Journal: BMJ (2014)

Indian biomedical researchers have echoed Prime Minister Narendra Modi’s recent admission that India is lagging behind in medical research. Modi made his comments in an address at the All India Institute of Medical Sciences, New Delhi, on 20 October. 

Researchers told The BMJ that acknowledgment of the problem by the prime minister is a good sign, but widespread structural changes are needed for the problem to be addressed effectively. 

Satyajit Mayor, a biologist and the director of the National Centre for Biological Sciences in Bangalore, said, “That clinical and biomedical research is at a very low ebb in the country is absolutely true, even though there is a huge opportunity because of the genetic diversity among our people. It is a major matter of concern in terms of the policies the government should put in place.” 

One reason for the lack of progress in medical research, the researchers said, is …
KERATINOCYTE PROLIFERATIVE HIERARCHIES CONFER PROTECTIVE MECHANISMS IN SURFACE EPITHELIA
Authors: W.J. Hume
Journal: British Journal of Dermatology (1985)

Journal Article KERATINOCYTE PROLIFERATIVE HIERARCHIES CONFER PROTECTIVE MECHANISMS IN SURFACE EPITHELIA Get access W.J. Hume W.J. Hume Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester M20 9BX, U.K. Dr W.J. Hume, Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester M20 9BX, England. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 112, Issue 4, 1 April 1985, Pages 493–502, https://doi.org/10.1111/j.1365-2133.1985.tb02326.x Published: 01 April 1985
Meeting information needs of patients with incurable progressive disease and their families in South Africa and Uganda: multicentre qualitative study
Authors: L. Selman, I. J Higginson, G. Agupio, N. Dinat, J. Downing, L. Gwyther, T. Mashao, K. Mmoledi, A. P Moll, L. M. Sebuyira, B. Panajatovic, R. Harding
Journal: BMJ (2009)

<b>Objectives</b> To explore the information needs of patients with progressive, life limiting disease and their family caregivers in South Africa and Uganda and to inform clinical practice and policy in this emerging field. <b>Design</b> Semistructured qualitative interview study. <b>Setting</b> Four palliative care services in South Africa and one in Uganda, covering rural, urban, and peri-urban locations. <b>Participants</b> 90 patients and 38 family caregivers enrolled in palliative care services; 28 patients had cancer, 61 had HIV infection (including 6 dual HIV/cancer diagnoses), and 1 had motor neurone disease. <b>Results</b> Five themes emerged from the data. (1) Information sources: a lack of information from general healthcare providers meant that patients and caregivers had to draw on alternative sources of information. (2) Information needs: patients and caregivers reported needing more information in the key areas of the causes and progression of the disease, its symptoms and treatment, and financial/social support. (3) Impact of unmet needs: poor provision of information had a detrimental effect on patients' and caregivers' ability to cope. (4) Communication: negative experiences of communication with general healthcare staff were reported (misinformation, secrecy, insensitivity). (5) Barriers to effective provision of information: barriers related to symptoms, culture, time constraints in hospital, and paternalism in general health care. <b>Conclusions</b> Lack of information was a major theme for both patients and carers, who had important unanswered questions relating to living with a progressive incurable disease. Evidence based recommendations for clinicians are presented, including the proactive provision of information tailored to individual patients and families.