tbuckley/cabot-search huggingface dataset:
Persistent yet reversible asymmetric pauciarthritis (PRAP): a B27-associated cluster.
Authors: T Bitter, M Jeannet, E de Haller, M Lejeune
Journal: Annals of the Rheumatic Diseases (1979)

t 'Minor' features of RS: (1) definite periostitis, (2) calcaneal spurs and/or erosions, (3) plantar fasciitis, (4) extensor tenosynovitis, (5) diffuse "sausage-like' swelling of isolated digits, (6) early morning low back pain (relieved by exercise), ( 7) rapid major weight loss, (8) acute onset. ( 9 mucuous membrane lesions or transient conjunctivitis without genital inflammation.
Stage I and II Follicular Non-Hodgkin’s Lymphoma: Long-Term Follow-Up of No Initial Therapy
Authors: Ranjana Advani, Saul A. Rosenberg, Sandra J. Horning
Journal: Journal of Clinical Oncology (2004)

Purpose To analyze the outcome of no initial therapy in stage I and II follicular small-cleaved (FSC) and follicular mixed (FM) non-Hodgkin’s lymphoma (NHL) on overall survival, time to treatment, incidence and course of transformation, and cause of death. Patients and Methods This was a retrospective analysis. Criteria for selection were patients with stage I and IIA FSC and FM (grades 1 and 2) NHL with therapy deferred for at least 3 months after diagnosis and a minimum follow-up of 1 year. Results Forty-three patients were identified (11 stage I, 32 stage II), with a median age of 58 years. Reasons for no initial therapy included: physician choice (n = 20), large abdominal radiation field required (n = 10), advanced age (n = 7), concern for xerostomia (n = 4), or patient refusal (n = 2). At a median follow-up of 86 months, 27 patients (63%) had not been treated. The median time to treatment in the remaining 16 patients was 22 months. Four of 16 patients transformed to a higher-grade lymphoma. Nine patients died—six due to progressive lymphoma. Estimated survivals at 5, 10, and 20 years were 97%, 85%, and 22%, respectively. Conclusion In selected stage I and II follicular NHL patients, deferred therapy is an acceptable approach, as more than half of our patients remained untreated at a median of 6 or more years, and survival was comparable to that seen in reports with immediate treatment.
Acquisition and synthesis of folates by obligate intracellular bacteria of the genus Chlamydia.
Authors: H Fan, R C Brunham, G McClarty
Journal: Journal of Clinical Investigation (1992)

We undertook studies focused on folate acquisition by Chlamydia trachomatis L2, Chlamydia psittaci 6BC, and C. psittaci francis. Results from in situ studies, using wild-type host cells, confirmed that C. trachomatis L2 and C. psittaci 6BC are sensitive to sulfonamides whereas C. psittaci francis is resistant. In addition C. trachomatis L2 and C. psittaci francis were inhibited by methotrexate in situ whereas C. psittaci 6BC was not. In contrast to C. trachomatis, neither C. psittaci strain was affected by trimethoprim. Surprisingly our results indicate that all three strains are capable of efficient growth in folate-depleted host cells. When growing in folate-depleted cells C. psittaci francis becomes sensitive to sulfonamide. The ability of all three strains to carry out de novo folate synthesis was demonstrated by following the incorporation of exogenous [3H]pABA into intracellular folates and by detecting dihydropteroate synthase activity in reticulate body crude extract. Dihydrofolate reductase activity was also detected in reticulate body extract. In aggregate the results indicate that C. trachomatis L2, C. psittaci francis, and C. psittaci 6BC can all synthesize folates de novo, however, strains differ in their ability to transport preformed folates directly from the host cell.
Tumor-Infiltrating Lymphocytes in Glioblastoma Are Associated with Specific Genomic Alterations and Related to Transcriptional Class
Authors: W. Caleb Rutledge, Jun Kong, Jingjing Gao, David A. Gutman, Lee A.D. Cooper, Christina Appin, Yuna Park, Lisa Scarpace, Tom Mikkelsen, Mark L. Cohen, Kenneth D. Aldape, Roger E. McLendon, Norman L. Lehman, C. Ryan Miller, Matthew J. Schniederjan, Cameron W. Brennan, Joel H. Saltz, Carlos S. Moreno, Daniel J. Brat
Journal: Clinical Cancer Research (2013)

Tumor-infiltrating lymphocytes (TIL) have prognostic significance in many cancers, yet their roles in glioblastoma have not been fully defined. We hypothesized that TILs in glioblastoma are associated with molecular alterations, histologies, and survival.
AMENORRHEA IN ELITE ATHLETICS ATHLETES: PREVALENCE AND ASSOCIATIONS TO ATHLETICS INJURY
Authors: M Rost, J Jacobsson, Ö Dahlström, M Hammar, T Timpka
Journal: British Journal of Sports Medicine (2014)

Background Knowledge is lacking about the associations between sport injuries and components of the female athlete triad. Objective To assess the prevalence of amenorrhea in elite female athletics athletes and if athletes with history of amenorrhea are at higher injury risk than athletes with regular menstrual cycles or on combined oral contraceptives. Design Cohort study during a period of 52 weeks. Setting Swedish female youth and adult elite athletics athletes. Participants Athletes ranked in the national top-10 in each event were invited to take part in a 52-week surveillance study. Among the female athletes that consented to participate (n=161), 149 (92%) completed a baseline gynecological survey. Risk factor assessment Amenorrhea, event group, previous injury, training volume and intensity (measured by the TLRI), and interactions with age. Main outcome measurements Time to first injury causing full or partial time loss from athletics. Results 37 (25%) athletes reported having history of amenorrhea. More runners reported amenorrhea (P=.017; Cramer's V=0.19) than athletes in the throwing and jumping event groups; this difference in amenorrhea prevalence was distributed to adult runners only (P=.016; Cramer's V=0.26). Additionally, there was a tendency for that runners with a lower BMI had a prevalence of amenorrhea (P=.062). Sixty-six percent of the athletes sustained an injury during the study period. Cox proportional hazards regression analyses did not show statistical associations between amenorrhea and athletics injury. Conclusions Swedish female athletics athletes reported a high prevalence of amenorrhea compared to the normal population. Athletes with extended exposure to participation in running events with high demands on aerobic performance sufferred more extensively from amenorrhea. No associations with injury incidence could be established, but this finding needs to be confirmed in studies with larger sample size. Further studies of amenorrhea and its health implications among female athletes are warranted.
Common variants at 5q22 associate with pediatric eosinophilic esophagitis
Authors: Marc E Rothenberg, Jonathan M Spergel, Joseph D Sherrill, Kiran Annaiah, Lisa J Martin, Antonella Cianferoni, Laura Gober, Cecilia Kim, Joseph Glessner, Edward Frackelton, Kelly Thomas, Carine Blanchard, Chris Liacouras, Ritu Verma, Seema Aceves, Margaret H Collins, Terri Brown-Whitehorn, Phil E Putnam, James P Franciosi, Rosetta M Chiavacci, Struan F A Grant, J Pablo Abonia, Patrick M A Sleiman, Hakon Hakonarson
Journal: Nature Genetics (2010)
Randomized phase II trial of irinotecan and bevacizumab as neo-adjuvant and adjuvant to temozolomide-based chemoradiation compared with temozolomide-chemoradiation for unresectable glioblastoma: final results of the TEMAVIR study from ANOCEF
Authors: B. Chauffert, L. Feuvret, F. Bonnetain, L. Taillandier, D. Frappaz, H. Taillia, R. Schott, J. Honnorat, M. Fabbro, I. Tennevet, F. Ghiringhelli, J.S. Guillamo, X. Durando, D. Castera, M. Frenay, C. Campello, C. Dalban, J. Skrzypski, O. Chinot
Journal: Annals of Oncology (2014)
Comparing Adult and Pediatric Rhabdomyosarcoma in the Surveillance, Epidemiology and End Results Program, 1973 to 2005: An Analysis of 2,600 Patients
Authors: Iyad Sultan, Ibrahim Qaddoumi, Sameer Yaser, Carlos Rodriguez-Galindo, Andrea Ferrari
Journal: Journal of Clinical Oncology (2009)

Purpose To compare clinical features and outcomes of adults and children reported to have rhabdomyosarcoma. Patients and Methods We analyzed data from 1,071 adults (age &gt; 19 years) and 1,529 children (age ≤ 19 years) reported in the public-access Surveillance, Epidemiology and End Results database as having rhabdomyosarcoma, diagnosed from 1973 to 2005. Survival estimates were determined using survival time with the end point being death from any cause. Results Adults with rhabdomyosarcoma had significantly worse outcome than children (5-year overall survival rates, 27% ± 1.4% and 61% ± 1.4%, respectively; P &lt; .0001). Tumors in adults were more likely to be at an unfavorable site (65% v 55%; P &lt; .0001) and to have histologies that are unusual during childhood, particularly the pleomorphic subtype (19%) and not otherwise specified (43%). Regional and distant spread was not more frequent in adults. Adults had significantly worse outcome than children with similar tumors. The most significant difference was in localized disease; 5-year survival estimates were 82% ± 2.0% for children and 47% ± 2.9% for adults (P &lt; .0001). Multivariate analysis showed that age, histologic subtype, primary site location, stage, and local control with surgery and/or radiation were significant predictors of survival. However, alveolar subtype and unfavorable primary site lost significance when analysis was restricted to adults. Conclusion Adults reported to have rhabdomyosarcoma had worse survival than children with similar tumors. Predictors of poor outcome in children were valid in adults except for alveolar histology and unfavorable tumor site.
Global Gene Expression Profile of Nasopharyngeal Carcinoma by Laser Capture Microdissection and Complementary DNA Microarrays
Authors: Virote Sriuranpong, Apiwat Mutirangura, John W. Gillespie, Vyomesh Patel, Panomwat Amornphimoltham, Alfredo A. Molinolo, Veerachai Kerekhanjanarong, Siripornchai Supanakorn, Pakpoom Supiyaphun, Samreung Rangdaeng, Narin Voravud, J. Silvio Gutkind
Journal: Clinical Cancer Research (2004)

Abstract A number of genetic and epigenetic changes underlying the development of nasopharyngeal carcinomas have recently been identified. However, there is still limited information on the nature of the genes and gene products whose aberrant expression and activity promote the malignant conversion of nasopharyngeal epithelium. Here, we have performed a genome-wide transcriptome analysis by probing cDNA microarrays with fluorescent-labeled amplified RNA derived from laser capture microdissected cells procured from normal nasopharyngeal epithelium and areas of metaplasia-dysplasia and carcinoma from EBV-associated nasopharyngeal carcinomas. This approach enabled the identification of genes differentially expressed in each cell population, as well as numerous genes whose expression can help explain the aggressive clinical nature of this tumor type. For example, genes indicating cell cycle aberrations (cyclin D2, cyclin B1, activator of S-phase kinase, and the cell cycle checkpoint kinase, CHK1) and invasive-metastatic potential (matrix metalloproteinase 11, v-Ral, and integrin β4) were highly expressed in tumor cells. In contrast, genes underexpressed in tumors included genes involved in apoptosis (B-cell CLL/lymphoma 6, secretory leukocyte protease inhibitor, and calpastatin), cell structure (keratin 7 and carcinoembryonic antigen-related cell adhesion molecule 6), and putative tumor suppressor genes (H-Ras-like suppressor 3, retinoic acid receptor responder 1, and growth arrested specific 8) among others. Gene expression patterns also suggested alterations in the Wnt/β-catenin and transforming growth factor β pathways in nasopharyngeal carcinoma. Thus, expression profiles indicate that aberrant expression of growth, survival, and invasion-promoting genes may contribute to the molecular pathogenesis of nasopharyngeal carcinoma. Ultimately, this approach may facilitate the identification of clinical useful markers of disease progression and novel potential therapeutic targets for nasopharyngeal carcinoma.
DNA methylation and childhood asthma in the inner city
Authors: Ivana V. Yang, Brent S. Pedersen, Andrew Liu, George T. O'Connor, Stephen J. Teach, Meyer Kattan, Rana Tawil Misiak, Rebecca Gruchalla, Suzanne F. Steinbach, Stanley J. Szefler, Michelle A. Gill, Agustin Calatroni, Gloria David, Corinne E. Hennessy, Elizabeth J. Davidson, Weiming Zhang, Peter Gergen, Alkis Togias, William W. Busse, David A. Schwartz
Journal: Journal of Allergy and Clinical Immunology (2015)
Regulatory T Cells Recruited through CCL22/CCR4 Are Selectively Activated in Lymphoid Infiltrates Surrounding Primary Breast Tumors and Lead to an Adverse Clinical Outcome
Authors: Michael Gobert, Isabelle Treilleux, Nathalie Bendriss-Vermare, Thomas Bachelot, Sophie Goddard-Leon, Vanessa Arfi, Cathy Biota, Anne Claire Doffin, Isabelle Durand, Daniel Olive, Solène Perez, Nicolas Pasqual, Christelle Faure, Isabelle Ray-Coquard, Alain Puisieux, Christophe Caux, Jean-Yves Blay, Christine Ménétrier-Caux
Journal: Cancer Research (2009)

Abstract Immunohistochemical analysis of FOXP3 in primary breast tumors showed that a high number of tumor-infiltrating regulatory T cells (Ti-Treg) within lymphoid infiltrates surrounding the tumor was predictive of relapse and death, in contrast to those present within the tumor bed. Ex vivo analysis showed that these tumor-infiltrating FOXP3+ T cells are typical Treg based on their CD4+CD25highCD127lowFOXP3+ phenotype, their anergic state on in vitro stimulation, and their suppressive functions. These Ti-Treg could be selectively recruited through CCR4 as illustrated by (a) selective blood Treg CCR4 expression and migration to CCR4 ligands, (b) CCR4 down-regulation on Ti-Treg, and (c) correlation between Ti-Treg in lymphoid infiltrates and intratumoral CCL22 expression. Importantly, in contrast to other T cells, Ti-Treg are selectively activated locally and proliferate in situ, showing T-cell receptor engagement and suggesting specific recognition of tumor-associated antigens (TAA). Immunohistochemical stainings for ICOS, Ki67, and DC-LAMP show that Ti-Treg were close to mature DC-LAMP+ dendritic cells (DC) in lymphoid infiltrates but not in tumor bed and were activated and proliferating. Furthermore, proximity between Ti-Treg, CD3+, and CD8+ T cells was documented within lymphoid infiltrates. Altogether, these results show that Treg are selectively recruited within lymphoid infiltrates and activated by mature DC likely through TAA presentation, resulting in the prevention of effector T-cell activation, immune escape, and ultimately tumor progression. This study sheds new light on Treg physiology and validates CCR4/CCL22 and ICOS as therapeutic targets in breast tumors, which represent a major health problem. [Cancer Res 2009;69(5):2000–9]
GASTRO-INTESTINAL SEPSIS A CAUSE OF MENIERE'S SYMPTOMS
Authors: T. M. Hovell
Journal: BMJ (1917)

lhealthy joints which had been confined for months came out undamaged from montlhs of continuously enforced rest.Yet there is one of hlis observations wlhich does bear on the utility of movement in preventing ankylosis.He remarks on the rarity of ankylosis in the joints between ribs and spine.Tlhey are joints at whiclh movements go
Enhanced Thromboxane Biosynthesis in Patients with Chronic Obstructive Pulmonary Disease
Authors: GIOVANNI DAVÌ, STEFANIA BASILI, MARIO VIERI, FRANCESCO CIPOLLONE, STELLA SANTARONE, CESARE ALESSANDRI, PIERPAOLO GAZZANIGA, CORRADO CORDOVA, FRANCESCO VIOLI
Journal: American Journal of Respiratory and Critical Care Medicine (1997)

Thrombotic complications of pulmonary circulation occur in patients with chronic obstructive pulmonary disease (COPD). In the present study, we sought to evaluate in vivo platelet activation through the measurement of 11-dehydro-thromboxane (Tx) B2, TxA2 major metabolite in the urine, in 29 patients with COPD, compared with 29 sex- and age-matched healthy subjects. The urinary excretion of 11-dehydro-TxB2 was significantly higher in patients with COPD than in control subjects: median (range), 753 (277–4,409) and 275 (129–612) pg/mg creatinine, respectively; p < 0.0001). Moreover, 11-dehydro-TxB2 excretion was inversely related with arterial oxygen tension (rho = − 0.46; p = 0.0145). In five of the 29 patients a short-term therapeutic course with oxygen supplementation induced a significant decrease of urinary 11-dehydro-TxB2 excretion: median range, 941 (452–2,640) to 445 (166–1,560) pg/mg creatinine. Moreover, selective inhibition of platelet cyclooxygenase activity by low-dose aspirin was associated with more than 90% inhibition of thromboxane metabolite excretion, demonstrating its being of platelet origin. Plasma levels of prothrombin fragment F1 + 2 were higher in patients than in control subjects (2.6 ± 1.5 versus 0.9 ± 0.4 nM, p = 0.0001). No relation between 11-dehydro-TxB2 excretion and plasma F1 + 2 levels was found. We conclude that platelet TxA2 biosynthesis is enhanced in patients with COPD and may be influenced by arterial oxygen tension changes. Davı̀ G, Basili S, Vieri M, Cipollone F, Santarone S, Alessandri C, Gazzaniga PP, Cordova C, Violi F, Chronic Obstructive Bronchitis and Haemostasis Study Group. Enhanced thromboxane biosynthesis in patients with chronic obstructive pulmonary disease.
Synergy Between Adiposity, Insulin Resistance, Metabolic Risk Factors, and Inflammation in Adolescents
Authors: Rae-Chi Huang, Trevor A. Mori, Valerie Burke, John Newnham, Fiona J. Stanley, Louis I. Landau, Garth E. Kendall, Wendy H. Oddy, Lawrence J. Beilin
Journal: Diabetes Care (2009)

OBJECTIVE The purpose of this study was to investigate relationships between inflammatory markers and components of a metabolic syndrome cluster in adolescents. RESEARCH DESIGN AND METHODS This was a cross-sectional analysis of an Australian childhood cohort (n = 1,377) aged 14 years. Cluster analysis defined a “high-risk” group similar to adults with metabolic syndrome. Relevant measures were anthropometry, fasting insulin, glucose, lipids, inflammatory markers, liver function, and blood pressure. RESULTS Of the children, 29% fell into a high-risk metabolic cluster group compared with 2% by a pediatric metabolic syndrome definition. Relative to the “low-risk” cluster, they had higher BMI (95% CI 19.5–19.8 vs. 24.5–25.4), waist circumference (centimeters) (95% CI 71.0–71.8 vs. 83.4–85.8), insulin (units per liter) (95% CI 1.7–1.8 vs. 3.5–3.9), homeostasis model assessment (95% CI 1.7–1.8 vs. 3.5–3.9), systolic blood pressure (millimeters of mercury) (95% CI 110.8–112.1 vs. 116.7–118.9), and triglycerides (millimoles per liter) (95% CI 0.78–0.80 vs. 1.25–1.35) and lower HDL cholesterol (millimoles per liter) (95% CI 1.44–1.48 vs. 1.20–1.26). Inflammatory and liver function markers were higher in the high-risk group: C-reactive protein (CRP) (P &amp;lt; 0.001), uric acid (P &amp;lt; 0.001), alanine aminotransferase (ALT) (P &amp;lt; 0.001), and γ-glutamyl transferase (GGT) (P &amp;lt; 0.001). The highest CRP, GGT, and ALT levels were restricted to overweight children in the high-risk group. CONCLUSIONS Cluster analysis revealed a strikingly high proportion of 14 year olds at risk of cardiovascular disease–related metabolic disorders. Adiposity and the metabolic syndrome cluster are synergistic in the pathogenesis of inflammation. Systemic and liver inflammation in the high-risk cluster is likely to predict diabetes, cardiovascular disease, and nonalcoholic fatty liver disease.
A proof-of-principle pharmacokinetic, pharmacodynamic, and clinical study with purine nucleoside phosphorylase inhibitor immucillin-H (BCX-1777, forodesine)
Authors: Varsha Gandhi, John M. Kilpatrick, William Plunkett, Mary Ayres, Leigh Harman, Min Du, Shanta Bantia, Jan Davisson, William G. Wierda, Stefan Faderl, Hagop Kantarjian, Deborah Thomas
Journal: Blood (2005)
Uric acid regulates hepatic steatosis and insulin resistance through the NLRP3 inflammasome-dependent mechanism
Authors: Xingyong Wan, Chengfu Xu, Yiming Lin, Chao Lu, Dejian Li, Jianzhong Sang, Haijian He, Xiao Liu, Youming Li, Chaohui Yu
Journal: Journal of Hepatology (2015)
Adverse Prognostic Effect of Methylation in Colorectal Cancer Is Reversed by Microsatellite Instability
Authors: Robyn Lynne Ward, Kay Cheong, Su-Lyn Ku, Alan Meagher, Terence O’Connor, Nicholas John Hawkins
Journal: Journal of Clinical Oncology (2003)

DNA methylation is an important biologic event in colorectal cancer and in some cases is associated with the development of microsatellite instability (MSI). In this study, we sought to determine the prognostic significance of DNA methylation, both in univariate analysis and in concert with other clinicopathologic factors known to influence outcome.Fresh tissue (625 cancers) was obtained from 605 individuals (age range, 29 to 99 years) undergoing curative surgery for colorectal cancer at one institution during a period of 8 years. Clinicopathologic details were recorded for all tumors, including stage, grade, type, vascular space invasion, and clinical follow-up to 5 years. Microsatellite status was assessed using standard markers. Methylation of p16 and hMLH1 promoters was determined by methylation-specific polymerase chain reaction (PCR), whereas methylation at methylated-in-tumor loci (MINT)1, MINT2, MINT12, and MINT31 loci were assessed by bisulfite-PCR.Patients with microsatellite unstable tumors (12%) had better disease-specific survival than those with microsatellite stable (MSS) tumors (univariate analysis: hazard ratio [HR], 0.53; 95% CI, 0.27 to 1.0). Overall survival of individuals with MSS tumors was influenced by three independently significant factors: tumor stage (HR, 7.3; 95% CI, 5.1 to 10.4), heavy tumor methylation (HR, 2.1; 95% CI, 1.1 to 4.0), and vascular space invasion (HR, 1.9; 95% CI, 1.3 to 2.9). In MSS tumors, methylation at any single site was not independently predictive of survival. Neither methylation nor microsatellite status predicted a favorable response to chemotherapy.DNA methylation is associated with a worse outcome in colorectal cancer, but this adverse prognostic influence is lost in those methylated tumors showing MSI. The mechanisms of these events warrant additional investigation.
Small Bowel Motility Affects Glucose Absorption in a Healthy Man
Authors: Matthijs P. Schwartz, Melvin Samsom, Willem Renooij, Leo W. van Steenderen, Marc A. Benninga, Erwin-Jan M. van Geenen, Margot A. van Herwaarden, Martin B.M. de Smet, André J.P.M. Smout
Journal: Diabetes Care (2002)

To investigate the relationship between duodenojejunal motor activity and glucose absorption and to evaluate the effect of modification of duodenojejunal motility on glucose absorption by using the prokinetic drug cisapride.We examined seven healthy males, mean age 22 years, who were treated with cisapride 10 mg t.i.d. and placebo during 3 days in a randomized order, with a 2-week time interval. Duodenojejunal manometry was performed after each treatment on the morning of day 3, using an 18-lumen catheter. A liquid nutrient (3 kcal/min) was administered intraduodenally for 30 min, followed by a bolus of the glucose analog 3-O-methylglucose (3-OMG). Plasma 3-OMG concentrations were measured to assess absorption kinetics.The area under the 3-OMG concentration curve in the first 30 min after infusion was related to the number of antegrade propagated pressure waves (r = 0.49, P < 0.05), but not to the peak concentration, time to peak, and absorption fraction. The mean amplitude of pressure waves was higher during cisapride than placebo (P < 0.05), but the reoccurrence of interdigestive motility, numbers of pressure waves, and propagated pressure waves, as well as 3-OMG absorption characteristics, were not significantly different between the two treatments. During both treatments >60% of antegrade propagated pressure waves were propagated over a very short distance (1.5 cm).Glucose absorption in the human small intestine is related to short-traveling propagated intestinal contractile activity. Cisapride increases the amplitude of pressure waves, but does not affect the organization of pressure waves or the absorption of 3-OMG.