tbuckley/cabot-search huggingface dataset:
Normalization of Antibody Responsiveness in a Patient with Common Variable Hypogammaglobulinemia and HIV Infection
Authors: J J Wright, D L Birx, D K Wagner, T A Waldmann, R M Blaese, T A Fleisher
Journal: New England Journal of Medicine (1987)

COMMON variable hypogammaglobulinemia is an immunodeficiency disorder characterized by decreased serum immunoglobulin levels, impaired antibody responses to most antigens, and increased susceptibility to infection.1 , 2 Cellular immunity may be intact, although at least half the patients have some evidence of decreased cellular immune responses as evaluated by delayed-type hypersensitivity or lymphocyte proliferative responses.3 Several possible mechanisms for common variable hypogammaglobulinemia have been proposed on the basis of in vitro assessment of immunoglobulin production. The majority of patients have an intrinsic defect in B-cell maturation or function that precludes in vivo or in vitro antibody synthesis.4 , 5 A number of patients have impaired . . .
The Hyperventilation Syndrome: Research and Clinical Treatment
Authors: Donald W. Goodwin
Journal: JAMA (1987)

<i>DSM-III</i>—the<i>Diagnostic and Statistical Manual</i>of the American Psychiatric Association—contains some 150 disorders. The newly revised edition contains even more. Neither volume includes the hyperventilation syndrome, the subject of this monograph. The author, Robert Fried, is unhappy about this. He points out that anxious people hyperventilate. Hyperventilation causes anxiety. This is so well known, he believes, that omitting the hyperventilation syndrome is incomprehensible. <i>DSM-III</i>did not overlook breathing. It frequently uses words like "dyspnea," "smothering sensations," or "sighing." Dyspnea, in fact, is the first symptom listed in connection with panic disorder. What bothers the author is that hyperventilation was not only ignored as a syndrome but not even mentioned in the index. Should it have been? There is no question that breathing is almost always affected by anxiety. If this takes the form of hyperventilation, the result is reduced blood CO<sub>2</sub>level and alkalosis. These in turn produce
Microbial eczema of the feet
Authors: K. WEISMANN, N. HJORTH
Journal: British Journal of Dermatology (1982)

Twenty-seven patients were investigated for eczema of the feet which mainly affected the medial interdigital spaces and the dorsal areas of the medial toes. The lesions tended to spread to the dorsum of the foot, rather than the plantar surface as seen in tinea pedis, which typically affects the lateral interdigital spaces. In all patients S. aureus and/or haemolytic streptococci were cultured, whereas scrapings for fungi were negative. All responded well to treatment aimed at eradicating bacteria and dermatitis, but relapses occurred in 33% of the cases. We believe this clinical entity is due to infective dermatitis in which the presence of bacteria provokes an eczematous response in the host, probably due to pre-existing sensitization rather than direct infection.
Determination Of Group 1 and 2 Isoforms From House Dust Mite Using Different Antibody Based Assays
Authors: H. Henmar, L.H. Christensen, G.N. Hansen, G. Larsen, L.B. Andersen, K. Bergmann, L. Lund, M.B. Skydtsgaard
Journal: Journal of Allergy and Clinical Immunology (2011)
Meat, Potatoes, and Growth Hormone
Authors: John D. Crawford
Journal: New England Journal of Medicine (1981)

Most of us consider bigger to be better, at least in the context of height. We speak of a person whose accomplishments are remarkable as a person "of stature." Schoolteachers and pediatric psychologists recognize the favored position of the tall child, whose innate abilities, both intellectual and social, are generally developed more rapidly than those of the small child, whose appearance invites "babying." The world of adults is no less biased, perhaps explaining why no one is more anxious for treatment of a short child than the similarly stigmatized parent.Particularly disadvantaged by their extreme shortness are children with a . . .
Primary Care, 2200 AD
Authors: DARRON R. BROWN
Journal: Annals of Internal Medicine (1987)

Ad Libitum1 May 1987Primary Care, 2200 ADDARRON R. BROWN, M.D.DARRON R. BROWN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-106-5-785_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Excerpt"My interrogator sent me to you. It thinks I'm psychopregnant.""Why? How do you feel?""Well, I'm bloated, and the babies in the condensing vats look so cute . . .""But all women feel this way at times. Do you really think you're psychopregnant?""How do I know? That's why I'm here-to find out if it's just an alpha-2 burst or the real thing ...""Well, let's find out!"The psycho-obstetrician was worried today. Not only was he having that gnawing pain in his chest again, but this was the third woman in the past month who thought... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1987Volume 106, Issue 5Page: 785-785KeywordsThorax Issue Published: 1 May 1987 PDF DownloadLoading ...
Silicone Breast Implant Story.
Authors: B. FREUNDLICH
Journal: Annals of the Rheumatic Diseases (1997)

European Rheumatologists in Training (EULAR Standing Committee for Education and Training)EURORITS Travel Bursary Scheme was established to improve the interaction between junior rheumatologists in diVerent European countries and increase their awareness, knowledge, and experience of rheumatology as practised throughout Europe.
Utilization of tomotherapy-based topotherapy for emerging breast radiation techniques: boost integration and accelerated partial breast irradiation.
Authors: A McIntosh, K Sheng, SR Khandelwal, DW Arthur, KJ Ruchala, GH Olivera, S Jeswani, PW Read
Journal: Cancer Research (2009)

Abstract Abstract #5148 Background: Helical Tomotherapy-based intensity modulated radiation therapy (IMRT) can be delivered using fixed gantry angles, known as Topotherapy, with daily image guidance. With the advent of accelerated or hypofractionated treatment schemes to shorten courses of radiation, conformality and accuracy is imperative for breast radiotherapy techniques since high doses of targeted radiation are used. The purpose of this study was to characterize the dosimetry of Topotherapy for delivery of Accelerated Partial Breast Irradiation (APBI) and hypofractionated Simultaneous Integrated Boost (SIB) breast irradiation in comparison with conventional techniques.&amp;#x2028; Materials and Methods: Ten patients with early stage left sided breast cancer were evaluated for this study using Topotherapy planning. The planning target volume (PTV) was contoured as the lumpectomy cavity with a 1.5cm margin, and the breast was defined by the tissue encompassed by tangent fields minus the PTV and 5mm of skin. To evaluate SIB, nine patients were comparatively planned using a standard sequential treatment of 50Gy tangents to the whole breast with a 10Gy electron boost in 30 fractions versus Topotherapy integrated boost with the same cumulative dose in 25 fractions versus hypofractionated Topotherapy with 42.4Gy to the breast and 51.2Gy to the PTV in 16 fractions. For evaluation of APBI, 3cm hypothetical lumpectomy cavities were contoured in the four breast quadrants of a single patient, with a similar 1.5cm expansion and breast volume. Plans to deliver 38.5Gy in 10 fractions were generated for each lesion using Topotherapy and compared to 3-dimensional conformal radiation therapy (3DCRT) and IMRT using the dosimetric guidelines from the National Surgical Adjuvant Breast and Bowel Project B-39/Radiation Therapy Oncology Group 0413 protocol.&amp;#x2028; Results: Target coverage and dose to heart and lung were clinically equivalent when comparing Topotherapy APBI and SIB to conventional techniques. For ABPI, the Topotherapy conformality index was superior to 3DCRT for all breast quadrants, but inferior to IMRT for lesions located in the medial quadrants of the breast. For SIB, Topotherapy provided an improvement in conformality over conventional sequential techniques, however there was no intensity modulated comparison. Equivalent target uniformity was observed in all APBI techniques however for SIB, Topotherapy provided a superior uniformity index for the whole breast target.&amp;#x2028; Discussion: Topotherapy is capable of delivering clinically acceptable dosimetry for accelerated or hypofractionated breast radiation without compromising dose to structures at risk. This treatment modality will be utilized in the near future pending FDA approval. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 5148.
What's new in the new editions?
Authors: C. Hawkins
Journal: BMJ (1987)

Gone is the subheading Purity of the Dressers and Surgeons as is the picture of Professor Lister's carbolic spray and the use of leeches (choose the thinnest and most lively) for treating local congestion. Readers will have guessed that I am looking at the original edition and that purity refers to clean hands and dress and not to holiness. It was so full of practical help (much applicable today) with 233 illustrations that its achievement in reaching the centenary and becoming the oldest surgical textbook in the English language is understandable. Walter Pye, a surgeon at St Mary's Hospital, died young and it is a tribute to subsequent editors that its standard has been kept up and purpose maintained: practical help for senior students, young doctors in hospital, and for lone practitioners working in underdeveloped countries. This centenary edition is a worthy tribute and has a new look; the editor has been assisted by John Smith of Sheffield and 25 other contributors. Since 1977 the section on brain death and care of the dying has been expanded and much other material rewritten and brought up to date. The pictures are better, especially the halftones on matt paper; the fracture in the carpal scaphoid bone (page 273) can even be seen. The preface by James Kyle is a masterly statement about the principles of good medical practice? a modern Hippocratic oath.
Potentiation of the cardiovascular effects of nitroglycerin by N-acetylcysteine.
Authors: J D Horowitz, E M Antman, B H Lorell, W H Barry, T W Smith
Journal: Circulation (1983)

The biochemical basis of the mechanism of vasodilatation by nitroglycerin (NTG) has not been previously investigated in man. However, evidence from in vitro studies suggests that NTG induces activation of guanylate cyclase via a series of enzymatic reactions that are modulated by the availability of sulfhydryl groups. Cysteine appears to be particularly effective in potentiating guanylate cyclase activation by NTG. To determine whether hemodynamic responsiveness to NTG in man might be modulated by sulfhydryl availability, concentration-response curves for effects of intravenously infused NTG on mean arterial pressure (MAP) and mean pulmonary capillary wedge pressure (PCW) were obtained in 10 patients undergoing cardiac catheterization for investigation of chest pain. NTG infusion was repeated 10 min after the intravenous infusion of 100 mg/kg of the cysteine source N-acetylcysteine (NAC). NAC induced no significant hemodynamic effect, but after NAC infusion there was a significant reduction both in the NTG infusion rate associated with a 10% fall from control values in MAP (25.8 +/- 8.3 to 9.3 +/- 2.7 micrograms/min; p less than .01) and in the infusion rate inducing a 30% reduction in PCW (13.6 +/- 4.6 to 4.2 +/- 1.6 micrograms/min; p less than .02). In a control group of five patients who received no NAC, there was no significant change in responsiveness to NTG between infusions. It is concluded that NAC potentiates the vasodilator effects of NTG in man. This suggests that sulfhydryl availability and/or redox state may be determinants of in vivo responsiveness to NTG.
GP services in Ireland are not adequate to cope with rise in number of old people
Authors: M. Houston
Journal: BMJ (2002)

The Republic of Ireland has neither the right geographical spread of family doctors nor an adequate number to meet future demographic changes, the chairman of the Irish College of General Practitioners said last week.

Dr Richard Brennan was responding to preliminary figures from the 2002 Irish census, which predict a doubling by 2031 of people …
Intestinal perforation in Wegener's granulomatosis.
Authors: J Geraghty, I R Mackay, D C Smith
Journal: Gut (1986)

Wegener9s granulomatosis is a disease characterised by a necrotising vasculitis and granulomatous inflammation. The localised form involves the upper and/or lower respiratory tracts while in the commoner generalised form there is a widespread necrotising vasculitis and renal involvement. Intestinal involvement, which may be severe, has been detected at necropsy in 24% of cases. Gastrointestinal symptoms are uncommon, however, none being mentioned in a recent series of 87 cases. There has been only one reported case of intestinal perforation secondary to Wegener9s granulomatosis. We report a case of small and large bowel perforations in a patient with Wegener9s granulomatosis.
Serologic Evidence of Histoplasmosis in Sanatoriums in the U.S.
Authors: M. L. Furcolow
Journal: JAMA (1962)

A screening procedure was used to select patients on whom further tests for histoplasmosis were indicated. The tests revealed almost 3,400 (7.5%) positive serologic results in a group of 45,000 patients from more than 80 hospitals. Percentages of positive reactions varied with the histoplasmin sensitivity in the area from which the patients were drawn. Evidence is presented to show that at least one-fourth of these patients with positive serologic tests can be proved by adequate cultural procedures to have histoplasmosis, with or without tuberculosis. The seriousness and frequency of the severe type of histoplasmosis makes this a problem of increasing importance to the general practitioner and chest specialist.
Medical Education in the United States: A Change in Format
Authors: C. H. William Ruhe
Journal: JAMA (1974)

Statistics on medical education in the United States were first published inThe Journalin 1901. Subsequently, the issue containing such statistics became known as the  Number, and was published annually for 73 years. The 73RD ANNUAL REPORT ON MEDICAL EDUCATION appeared last year in the Nov 19, 1973, issue ofThe Journal.  This year, for the first time since the compilation began, the statistics on medical education will not appear in the regular pages ofThe Journalbut will rather be published separately in limited numbers. The decision to separate the Education Number was made because of the competition for editorial space.  The content will be similar to that of previous years. An initial section contains a brief review of Recent Events of Special Interest to Medical  including such items as the present status of the Coordinating Council on Medical Education, health manpower and health manpower legislation,
Traumatic Brain Injury Rates
Authors: M. J. Friedrich
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
P17. RIG-I-like helicases induce immunogenic cell death of pancreatic cancer cells
Authors: M Schnurr, A Steger, H Lohr, H Bourhis, S Endres, P Duewell
Journal: Journal for ImmunoTherapy of Cancer (2014)

Meeting abstracts We recently identified RIG-I-like helicases (RLH) as therapeutic targets of pancreatic cancer for counteracting immunosuppressive mechanisms and apoptosis induction. Here, we investigated immunogenic consequences of RLH-induced tumour cell death. Murine pancreatic cancer cells (
Consultant vacancies in the NHS--a short term solution?
Authors: P. Sykes
Journal: BMJ (1996)

There has been much concern recently about the inability of the NHS to attract consultants in many specialties and localities and anyone who has seen the curriculum vitae of applicants for consultant posts cannot fail to have noticed the decline in the number and quality of applicants. Historically, there has always been greater competition in certain specialties and in certain hospitals than in others, but at present even consultant posts in short stay medical and surgical specialties, which have previously been regarded as attractive, remain unfilled.

There are several causes for the present shortfall of consultant applicants: insufficient medical students; a fall out of graduates, particularly women, within three or four years of graduation; and unattractive postgraduate training programmes, which place little emphasis on education, and an undue emphasis on service. Other factors include the change in the work permit regulations, which have abruptly reduced the flow of overseas doctors, and the declining attraction of the consultant post as the pressure on consultants increases as ever more tasks have been allocated to them such as management, training of junior doctors, …
A?-haplotypes: A new group of genetic markers for thalassemic mutations inside the 5? regulatory region of the human A?-globin gene
Authors: George P. Patrinos, Panagoula Kollia, Elisavet Papapanagiotou, Aphrodite Loutradi-Anagnostou, Dimitris Loukopoulos, Manoussos N. Papadakis
Journal: American Journal of Hematology (2001)

This study illustrates the relationship between a group of nucleotide variations within the 5′ regulatory region of the Aγ-globin gene [Aγ-588 A→G, Aγ-499 T→A and the 4-bp deletion (Aγ-225 to -222 AGCA)] and the spectrum of δ- and β-thalassemia mutations in the Hellenic population. These sequence variations, screened by means of denaturing gradient gel electrophoresis, form four separate frameworks (Aγ-haplotypes), each one of which was found to be linked in cis with certain δ- and β-thalassemia mutations found in the Hellenic population. In addition, two novel base substitutions inside the 5′ regulatory region of the Aγ-globin gene (Aγ-521 C→A and Aγ-500 C→T) were identified during this study, which together with Aγ-haplotypes seem to be silent polymorphisms during adult life, as indicated by transient expression assays. Our data show that Aγ-haplotypes represent genetic markers for the spectrum of thalassemic mutations, found in the Hellenic population and can constitute an important genetic repository upon which mutations leading to thalassemia and hemoglobinopathies occurred. Am. J. Hematol 66:99–104, 2001. © 2001 Wiley-Liss, Inc.
Postoperative Myocardial Infarction
Authors: Fred Wasserman, Samuel Bellet, Robert P. Saichek
Journal: New England Journal of Medicine (1955)

RECENT developments in anesthesia, wider use of antibiotics, improved postoperative care and the increasing percentage of older people in the general population1 2 3 account for the performance of a wide range of operative procedures on older age groups, and on patients with known heart disease who are considered to be poor surgical risks. It is recognized that, in these groups particularly, cardiac complications before, during and after surgery present major hazards; of these, postoperative myocardial infarction is of considerable importance. In spite of the significance of this complication there have been relatively few detailed reports on this subject in recent years. . . .
Bordering on environmental disaster.
Authors: C W Schmidt
Journal: Environmental Health Perspectives (2000)

Millions of people live on the U.S.-Mexico border, drawn by employment opportunities from industry and agriculture, and booming growth is expected to continue in the coming decades. But the influx of people has long outstripped the capacity of border towns and cities to provide for their citizens, and a large percentage of the population lives in sprawling, underserviced shantytowns. Although investment in environmental infrastructure on both sides has led to improvements, shortages among necessities such as drinking water, wastewater treatment, and solid waste disposal are at crisis levels. In addition, a host of diseases including gastrointestinal infections, asthma, tuberculosis, multiple myeloma, systemic lupus erythematosus, hepatitis A, neural tube defects, and lead poisoning have been linked to environmental conditions on the border. Ongoing binational studies are attempting to define the breadth of the public and environmental health crisis and find ways to help make the border a healthier place.
Radiation Hazard to Patients
Authors: A. C. Glendinning
Journal: BMJ (1963)

It is suggested that most diaguostic radiologists are familiar with the main recommendations of the Report of the Adrian Committee on radiation hazards and aware of the types of x-ray examination which are undesirable from the viewpoint of radiation hazard. At the same time the fact remains that it is a universal practice in England for requests for x-ray examination to be made wholly by the clinical staff, and frequently by junior staff, very few of whom have even seen the report. This means that patients sent for skeletal examination are seldom seen by the radiologist at all, and those who are subjected to a possibly superfluous gastrointestinal investigation are usually on the screening stand when the radiologist meets them. It is proposed that it is necessary to reveal to practitioners other than radiologists the basic rules set out by the Adrian Committee. If these were generally observed it would remove much of the radiation hazard and at the same time relieve the radiologist from informing his clinical colleagues of the hazard. The directive should come from, and with the authority of, the Adrian Committee itself. (BBB)