The Significance of Fever in Neoplastic Disease
Authors: ANN A. BROWDER
Journal: Annals of Internal Medicine (1961)

Article1 December 1961The Significance of Fever in Neoplastic DiseaseANN A. BROWDER, M.D., JOHN W. HUFF, M.D., ROBERT G. PETERSDORF, M.D.ANN A. BROWDER, M.D., JOHN W. HUFF, M.D., ROBERT G. PETERSDORF, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-55-6-932 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFever is often a manifestation of neoplastic disease, and the literature is replete with case reports of patients who were febrile for months and even years before exhaustive investigation revealed a cryptic neoplasm. Hypernephroma is the prototype of tumor frequently associated with fever and is described in several series of patients with fever of unknown etiology (1-3). Actually, however, fever is a relatively rare symptom of renal cell carcinoma. Israel (4) reported that only 8.2% of 146 patients with hypernephroma were febrile, and Soloway (5) noted pyrexia in eight among his 130 patients. Among 273 patients with renal neoplasms reported...References1. HAMMANWAINWRIGHT LCW: Diagnosis of obscure fever. Bull. Johns Hopkins Hosp. 58: 109, (part 1); 307 (part 2), 1936. Google Scholar2. KINTNERROWNTREE ARLG: Long continued, low grade idiopathic fever: analysis of 100 cases. J. A. M. A. 102: 889, 1934. CrossrefGoogle Scholar3. PETERSDORFBEESON RGPB: Fever of unexplained origin: report on 100 cases. Medicine 40: 1, 1961. CrossrefMedlineGoogle Scholar4. ISRAEL J: Ueber einige neue Erfahrungen auf dem Gebiete der Nieren Chirugie. Deutsch. Med. Wschr. 22: 345, 1896. CrossrefGoogle Scholar5. SOLOWAY HM: Renal tumors: a review of 130 cases. J. Urol. 40: 477, 1938. CrossrefGoogle Scholar6. BERGERSINKOFF LMW: Systemic manifestations of hypernephroma: a review of 273 cases. Amer. J. Med. 22: 791, 1957. CrossrefMedlineGoogle Scholar7. 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Author, Article, and Disclosure InformationAffiliations: Seattle, WashingtonFrom the Department of Medicine, University of Washington School of Medicine, and King County Hospital, Seattle, Washington.This study was supported by Training Grant 2E-146, United States Public Health Service.Requests for reprints should be addressed to Robert G. Petersdorf, M.D., King County Hospital, 325 Ninth Avenue, Seattle 4, Washington. 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FINCH, M.D., F.A.C.P., YALE R. NEMERSON, M.D., MARSHALL G. BARNES, M.D.Infectious Complications of Neoplastic DiseasePersistent Perplexing Pyrexia: Some Comments on Etiology and DiagnosisCase 21-1967Infectious Complications of Chemotherapy in a Protected EnvironmentFever of Unknown OriginInfections, fever and host resistance in neoplastic diseasesTHE MANAGEMENT OF THE PATIENT WITH INOPERABLE MALIGNANT DISEASE 1 December 1961Volume 55, Issue 6Page: 932-942KeywordsFeversFistulasHospital medicineHospitalsLymphomaMedical servicesRenal cancerRenal cell carcinomaSarcomaUrinary tract infections Issue Published: 1 December 1961 PDF downloadLoading ...