D-Penicillamine-Induced Polymyositis in Rheumatoid Arthritis
Authors: BOBB G. CUCHER
Journal: Annals of Internal Medicine (1976)

Letters1 November 1976D-Penicillamine-Induced Polymyositis in Rheumatoid ArthritisBOBB G. CUCHER, M.D., A. L. GOLDMAN, M.D.BOBB G. CUCHER, M.D.Search for more papers by this author, A. L. GOLDMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-85-5-615 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptD-penicillamine is an effective treatment for active rheumatoid arthritis (1). As more experience is gained with this drug, the more apparent becomes its spectrum of toxicity. A lupus-like syndrome (2) and polymyositis (3) have been reported as complications of D-penicillamine therapy. This report describes a patient who, 1 month after beginning therapy for rheumatoid arthritis, manifested signs and symptoms of polymyositis associated with myocarditis, proteinuria, and hypocomplementemia.A 58-year-old woman was admitted to Columbia Hospital in Milwaukee, Wisconsin, 12 May 1975, for weakness. She had been in good health until 2½ years before admission when she was diagnosed as having...References1. : Controlled trial of D-penicillamine in severe rheumatoid arthritis. Lancet 1:275-280, 1973 MedlineGoogle Scholar2. HARPEY J, CAILLE B, and MOULIAS P: Lupus-like syndrome induced by D-penicillamine in Wilson's disease. Lancet 1:292, 1971 CrossrefMedlineGoogle Scholar3. SCHRAEDER P, PETERS H, and DAHL D: Polymyositis and penicillamine. Arch Neurol 27:456-457, 1972 CrossrefMedlineGoogle Scholar4. BOHAN A and PETER J: Polymyositis and dermatomyositis. N Engl J Med 292:344-347, 403-407, 1975 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: BOBB G. CUCHER, M.D.; A. L. GOLDMAN, M.D.Affiliations: Department of Medicine Columbia Hospital The Medical College of Wisconsin Milwaukee, WI 53226 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byJoint and muscle inflammatory disease: A scoping review of the published evidenceGold salts, D-penicillamine and allopurinolChapter 12 Neurotoxicology of neuromuscular transmissionGold salts, D-penicillamine and allopurinolDermatomyositis and DrugsNephrotoxicity of gold salts, D-penicillamine, and allopurinolD-penicillamine-induced myositis in rheumatoid arthritisOcular myasthenia: A protean disorderD-penicillamine induced polymyositis causing complete heart blockPolymyositis complicating d -penicillamine treatmentEfficacy of intravenous gammaglobulin therapy in chronic refractory polymyositis and dermatomyositis: An open study with 20 adult patientsRheumatic syndromes caused by antirheumatic drugsA Classification of Polymyositis and DermatomyositisAdverse Drug Reactions in the Horsed-penicillamine: Chemistry and clinical use in rheumatic diseaseD-penicillamine–induced polymyositis in patients with rheumatoid arthritisInflammatory Myopathy IPenicillamine-induced MyositisLess Common Causes of Myositisd-Penicillamine-induced myasthenia gravis in primary biliary cirrhosisCimetidine and PolymyositisFatal Polymyositis in D-Penicillamine-Treated Rheumatoid ArthritisDEBORAH R. DOYLE, M.D., THOMAS L. McCURLEY, M.D., JOHN S. SERGENT, M.D.d-Penicillamine-induced neuromuscular disease in guinea pigsD-Penicillamine-induced pemphigus syndromeHapten immunology and allergic reactions in humansTherapeutic quandaryPenicillamine-induced myositis in rheumatoid arthritisAdverse Effects of D-Penicillamine in Rheumatoid ArthritisHOWARD B. STEIN, M.D., A. CAROLINE PATTERSON, M.B., ROBERT C. OFFER, M.D., CHRISTOPHER J. ATKINS, M.B., ALVENA TEUFEL, R.N., HAROLD S. ROBINSON, M.D.Penicillamine-induced myasthenia gravisPtosis and Weakness after Start of D-Penicillamine TherapySTEVEN G. ATCHESON, M.D., JOHN R. WARD, M.D.DRUG-INDUCED MYOPATHIES IN MANToxicity of D-penicillamine in rheumatoid arthritisHeavy metal antagonistsPenicillamine-Inducedpolymyositis-DermatomyositisNeuromuscular Manifestations of Rheumatoid Arthritis: A Clinical and Histomorphological AnalysisD-Penicillamine-Induced Myasthenia Gravis in Rheumatoid ArthritisROBERT A. GORDON, M.D., JOHN W. BURNSIDE, M.D., F.A.C.P. 1 November 1976Volume 85, Issue 5Page: 615-616KeywordsAdverse reactionsMyocarditisPolymyositisProteinuriaRheumatoid arthritisSigns and symptomsToxicity ePublished: 1 December 2008 Issue Published: 1 November 1976 PDF downloadLoading ...