tbuckley/cabot-search huggingface dataset:
Judge rules in favour of "do not resuscitate"
Authors: C. Dyer
Journal: BMJ (1996)

Doctors caring for a severely disabled 23 year old man need not resuscitate him if he has a heart attack or stops breathing, ruled Sir Stephen Brown, England's senior family judge last week. The case went to the High Court in London because staff in the day centre where the man, named as R, spends some of his time had challenged South Buckinghamshire NHS Trust's decision to apply a “do not resuscitate” policy to him.

The Public Law Project, a legal charity, had won leave …
Canine Allergy: A Model of a Spontaneous Hypersensitivity Disease.
Authors: Roy Patterson
Journal: Annals of Internal Medicine (1964)

s1 February 1964Canine Allergy: A Model of a Spontaneous Hypersensitivity Disease.Roy Patterson, M.D., F.A.C.P., Jacob J. Pruzansky, Ph.D.Roy Patterson, M.D., F.A.C.P.Search for more papers by this author, Jacob J. Pruzansky, Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-2-328_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSpontaneous pollen allergy occurs in animals and provides a model of this type of hypersensitivity useful for laboratory investigation. A colony of four dogs with spontaneous pollen allergy has been established in order to study the clinical, immunologic, and pharmacologic abnormalities in these dogs and to compare these findings with those established in the human allergic patient. Clinical manifestations during the pollen season in these dogs include conjunctivitis, dermatitis, rhinitis, and asthma. These symptoms can be reproduced under controlled conditions of exposure to the specific aeroallergen. The immediate type of wheal and erythema reactivity is present and is transferrable to... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, Illinois PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1964Volume 60, Issue 2_Part_1Page: 328-328KeywordsAllergic diseasesAllergy and immunologyAsthmaClinical immunologyConjunctivitisErythemaHypersensitivityPollenResearch laboratoriesRhinitis Issue Published: 1 February 1964 PDF DownloadLoading ...
Eye Manifestations in Polycythemia
Authors: Karl W. Ascher
Journal: JAMA (1971)

To the Editor.—  Reading the important article by Drs. Edwards and Cooley about initial manifestations of polycythemia vera ( 214: 1463, 1970), I recalled experiences from my more than half a century of ophthalmologic research and practice. There are rare patients with therapy-resistant bilateral conjunctivitis of long duration. There is no discharge, no pain, but constant deep redness of both bulbi without preference to the pericorneal or to the equatorial area. Conjunctival and episcleral vessels are engorged and epinephrine instillations may somewhat reduce the redness for short periods. These patients see eye specialists and use prescriptions of eye drops without success.  The condition is easily recognized in good daylight but missed in the darkroom with focal illumination. The unfortunate trend to screen out daylight in ophthalmologic offices contributes to the oversight of this early sign of polycythemia. These patients should benefit from early recognition and proper diagnosis before more serious symptoms
Out of the closet
Authors: J. Napier
Journal: BMJ (1997)

On the day of my interview for a senior house officer rotation in general medicine, a more senior colleague gave me some unusual advice.

“When they ask you about your long term career ambitions, Jackie, you'd better not tell them the truth.”

Obediently, I dodged the question when it came, mentioning a (genuine) interest in neurology and failing to contradict the panel's assumption that I wished to become a neurologist. Having been given the job, I spent the next two years evading further inquiries, much to the exasperation of my consultants. Nearing the end of the rotation, with the ink barely dry on my membership certificate, I announced that I was joining the pharmaceutical industry as a medical adviser.

My news received a mixed reception, from those colleagues who said that they wished that they could do the same thing, to those who accused me, at best, of wasting my talents and, at worst, of betraying my profession. Many assumed that I would be working as a sales representative, this role embodying their sole experience of the industry. Eventually, I gave up trying to correct them.

Pharmaceutical medicine was never mentioned as a …
731 Interim results of a multiple ascending dose study of R1626, a novel nucleoside analog targeting hcv polymerase in chronic HCV patients
Authors: S. Roberts, G. Cooksley, D. Shaw, H.K. Berns, M.T. Brandl, S.H. Fettner, G. Hill, D. Ipe, K. Klumpp, M. Mannino, E. O'Mara, Y. Tuo, C.B. Washington
Journal: Journal of Hepatology (2006)
ABC of sexually transmitted diseases. Genital herpes.
Authors: M W Adler
Journal: BMJ (1983)

The problems associated with gerital herpes Increasing No curative treatment Recurrent Breakdown relationships / psychosexual problems/ depression ?Cervical dysplasia / carcinoma Neonatal infections Genital infection with herpes simplex virus poses six problems.It is increasing rapidly, it is an unpleasant disease with no cure, and it is recurrent, the last two of which may lead to breakdown of relationships, psychosexual problems, and depression; it may be associated with cervical dysplasia and carcinoma, and, finally, it may cause neonatal and possibly fetal infections.The latest figures (1981) show that 12080 cases (rate 22 per 100000) of genital herpes were seen in departments of genitourinary medicine in the United Kingdom.Even though these figures make it only the sixth most common sexually transmitted disease, it is the one that has shown the greatest increase in the past 10 years (168%).The number of cases and estimated rates in America, ranging from 87 to 217 per 100000, far exceed those in Britain, and there the disease is considered to be of epidemic proportions.Certainly, more cases exist than are diagnosed in departments of genitourinary medicine and these will be managed in general practice or by gynaecologists and dermatologists.
1094-154 Utility of fluorodeoxyglucose-positron emission tomography for predicting left ventricular functional recovery in patients with acute myocardial infarction after successful revascularization: Comparison with technetium-99m tetrofosmin SPECT
Authors: Haruhisa Shirasaki, Jong-dae Lee, Akira Nakano, Hiroyasu Uzui, Toru Geshi, Kiyohiro Toyoda, Naoki Amaya, Toshihiro Mizuguchi, Takanori Ueda
Journal: Journal of the American College of Cardiology (2004)
Primary care research lives
Authors: J. G Hillman, H. K MacNab
Journal: BMJ (2010)

Del Mar thinks that research in primary care is a lost cause1: not so.

One of us (JGH) instituted a glaucoma screening programme in a four partner general practice during 1991-4 using basic equipment (Snellen’s chart with and without a pinhole, ophthalmoscope, Perkins’ tonometer for intraocular pressure, and oculokinetic perimetry charts for visual fields). An additional hope was that screening with these methods might be applied in the developing world, where glaucoma is more prevalent and batteries may be the only energy …
Adult polycystic kidney disease and intracranial aneurysms.
Authors: A Saifuddin, J R Dathan
Journal: BMJ (1987)

Adult polycystic kidney disease and intracranial aneurysmsWe describe for the first time a family whose three members all had adult polycystic kidney disease and intracranial aneurysms. Case reportsCase I-A 34 year old man presented in 1981 with accelerated hypertension.Renal ultrasonography confirmed that he had polycystic kidneys.In 1985 he was admitted with a subarachnoid haemorrhage.Neurosurgery showed a right cerebral haematoma, probably from an intracranial aneurysm.This was evacuated, but he died soon afterwards.Case 2-A 39 year old woman, the sister of the patient in case 1, presented in 1978 with a subarachnoid haemorrhage.Cerebral arteriography showed bilateral intracranial aneurysms, but she was managed conservatively.In 1983 intravenous pyelography showed that she had polycystic kidneys.In 1986 she had a prolonged grand mal fit, and subsequently her renal function deteriorated.She was referred for continuous ambulatory peritoneal dialysis and remained well.Case 3-A 36 year old man, the brother of the patients in cases 1 and 2, presented in 1978 with haematuria.Intravenous urography showed that he had polycystic kidneys.In 1986 his family history became known and he underwent elective cerebral digital subtraction angiography, which showed an aneurysm 6 mm in diameter of the right middle cerebral artery (figure).This was clipped, and he remained well.Cerebral digital subtraction angiography showing aneurysm at trifurcation ofright middle cerebral artery.
Skin Fragility and Blister Formation
Authors: Huan J. Chang
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Investigation of Relation between Epicardial Fat Thicness and Reperfusion and Prognosis in ST Segment Elevated Myocardial Infarction Patients
Authors: Selçuk Kanat, Mevlüt Demir, Reşit Coşkun, Pınar Türker Bayır, Habibe Kafes, Mehmet Yılmaz, Serdar Akyel, Deniz Şahin, Özgül Uçar, Havva Tuğba Gürsoy, Serkan Çay, Mehmet İleri
Journal: Journal of the American College of Cardiology (2013)
The William C. Menninger Memorial Lecture: Biologic and Sociologic Changes Affecting Adaptation in Mid- and Late Life.
Authors: Ewald W. Busse
Journal: Annals of Internal Medicine (1971)

Meeting Abstracts1 May 1971The William C. Menninger Memorial Lecture: Biologic and Sociologic Changes Affecting Adaptation in Mid- and Late Life.Ewald W. Busse, M.D., F.A.C.P.Ewald W. Busse, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-74-5-843_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe behavioral and emotional changes that are frequently observed in mid- and late life are primarily determined by an interaction of biologic changes and socioeconomic factors. Primary aging, a series of biologic alterations, is usually observed as a decline in physiologic efficiency. These declines are widespread, and there is considerable variation between various parts of the body. Changes within the nervous system include alterations in perception, capacities to respond to stimuli, manifestations of anxiety, learning, and memory. These changes interact with social demands and expectations. Important changes within the body and environmental influences are identified. It is particularly important for... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Durham, N.C. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1971Volume 74, Issue 5Page: 843-843KeywordsAgingAnxietyBiologicsEmotionsMemoryMotivationNervous systemPerception Issue Published: 1 May 1971 PDF DownloadLoading ...
Hungarian drug firms threaten to cut supplies to hospitals
Authors: C. Kovac
Journal: BMJ (2002)

Hungary's largest pharmaceutical wholesalers are threatening to cut off drug supplies within a few months to as many as 120 of the country's 160 hospitals, all owned by municipalities or state universities, unless the government provides more money to pay hospitals' expenses.

A report by the Pharmaceutical Wholesalers Association contends that the hospitals owe more than three billion forints (£7.6m; $10.7m; €12.2m) to the country's four top drug …
Court upholds GMC decision over Sally Clark case pathologist
Authors: Clare Dyer
Journal: BMJ (2007)

the consultant pathologist whose failure to disclose the results of micro biological tests on one of Sally Clark's two baby sons led to the quashing of her murder convictions, lost his High Court appeal last week against a finding of serious professional misconduct.Mrs Clark was convicted in 1999 of kill ing babies Christopher and Harry but was cleared on appeal in 2003 after spending three and a half years in prison.She died earlier this year at the age of 42.A coroner ruled this week that the cause of her death was acute alcohol intoxication.A General Medical Council fitness to practise panel found Dr Williams, aged 58, guilty of serious professional misconduct in 2005 for not disclosing the results of tests on her second son, Harry, at or before her trial.Dr Williams was banned from doing Home Office forensic pathology or coro ners' work for three years, although he was allowed to continue working as a consult ant histopathologist at Macclesfield General Hospital, in Cheshire.His lawyers appealed on a range of issues, including delays in bringing his case before the GMC.But Mr Justice Davis ruled last week, "In my judg ment this appeal fails on essentially every ground advanced.There was no procedural unfairness giving rise to injustice; nor were the findings and conclusions of the panel wrong."Mrs Clark was cleared after a second appeal, when previously unreported micro biological results came to light.They showed the presence of Staphylococcus aureus at eight sites of the baby's body, including cerebro spinal fluid, raising the possibility that Harry died from natural causes.Dr Williams told the GMC panel that he had not considered the tests to be relevant and that if the defence had wished to see them, they should have asked for them. Court upholds GMC decision over Sally Clark case pathologistUK NEWS Charity warns of proposed restrictions to asylum seekers' access to care, p 1012 World NEWS �erck to pay ���n in rofeco�i� claims, p 1011 �erck to pay ���n in rofeco�i� claims, p 1011 , p 1011 �mj.com �o�ernment may lea�e some patients out of 1�� week tar�et �o�ernment may lea�e some patients out of 1�� week tar�et
Recurrent Septic Pulmonary Embolization Complicating Maintenance Hemodialysis
Authors: NORMA J. GOODWIN
Journal: Annals of Internal Medicine (1969)

Recurrent episodes of septic pulmonary embolization are described in three patients undergoing maintenance hemodialysis. Abnormalities of serum bilirubin, alkaline phosphatase, and serum glutamic-oxalacetic transaminase were observed in two patients and pericarditis with effusion and atrial fibrillation in one patient. Serial chest roentgenograms showed one or more small areas of infiltration in the peripheral lung fields. There was no correlation between gross evidence of local infection and the occurrence of septic pulmonary embolization. Hemodialysis treatments were often associated with an exacerbation of the clinical picture, suggesting infection in the region of the arteriovenous shunt as the cause. Once septic pulmonary emboli recurred in the same individual, antibacterial therapy was ineffective. The clinical course in these patients suggested that the indwelling foreign body—the arteriovenous shunt—was responsible for the poor response to antibiotics. The recommended treatment for recurrent septic pulmonary embolization complicating maintenance hemodialysis is removal of the shunt and control of systemic infection. Recannulation should be performed in a different extremity only after all signs of systemic infection have resolved.
Treatment of the Acute Urethral Syndrome
Authors: Walter E. Stamm, Kate Running, Mary McKevitt, George W. Counts, Marvin Turck, King K. Holmes
Journal: New England Journal of Medicine (1981)

ACUTE dysuria and frequent urination in young women results most commonly from three conditions: vaginitis, cystitis, and the acute urethral syndrome.1 2 3 In a recent study of women with the urethral syndrome, we found that 71 per cent had abnormal pyuria, defined as ≥8 leukocytes per cubic millimeter of midstream urine. Furthermore, 88 per cent of women with pyuria were found to have lower-urinary-tract infection with less than 105 coliforms or staphylococci per milliliter of urine or with Chlamydia trachomatis.3 Since all these agents should respond to antimicrobial therapy, treatment of women with the acute urethral syndrome has been recommended, . . .
Cost effectiveness has its place, but so does common sense
Authors: R. Rappuoli, J. Wassil, L. Bonefeld, J. Porter
Journal: BMJ (2014)

Cost effectiveness models are useful tools for equitable rationing of health budgets but should not be the only component of the decision making process. This is particularly true for vaccination of children for rare diseases, where crucial parameters are inherently uncertain. In this case, the uncertainty is evident; Christensen and colleagues’ paper is the third iteration of the model,1 with each leading to different conclusions …
Abstract 3414: Disruption of CREB-CREBBP association by 2-Naphthol AS-E phosphate induces cell cycle arrest and apoptosis in non-small cell lung cancer cells .
Authors: Jong Woo Lee, Hee Sun Park, Seung-Hee Ryu, Patricia Koch, Julie Boyer, Daniel Morgensztern, Roy S. Herbst, Jaseok Peter Koo
Journal: Cancer Research (2013)

Abstract The cyclic-AMP response element-binding protein (CREB) plays a critical role in the growth and survival of cancer cells as well as cell metabolism. Our previous studies have shown that enhanced CREB activity correlates with increased growth and survival of non-small cell lung cancer (NSCLC) cell lines. In addition, 2-naphthol AS-E phosphate (NASEp), a small molecule inhibitor of CREB, restricted growth of NSCLC cell lines which was associated with reduced expression of pro-angiogenic factors. NASEp distrupts binding of CREB binding protein (CREBBP) to CREB, however, the mechanism which CREB inhibition by NASEp regulates NSCLC cell growth and survival is not fully understood. Here, we found that NASEp inhibited cell growth, survival, anchorage-independent cell growth and invasion, and also completely blocked the expression of Ki-67 and PCNA, markers of cell proliferation in NSCLC cells. Mechanistically, NASEp caused cell cycle arrest at the sub-G1 or G2 phase through down-regulation of several cyclins (cyclin A2, cyclin B1, cyclin D1 and cyclin E2) and led to apoptosis in NSCLC-derived cell lines. Suppression of cyclin D1 was closely related to decreased expression of activator protein-1 (AP-1). Furthermore, in a murine xenograft model, NASEp significantly reduced tumor burden not only by down-regulating of cyclin E2 and PCNA, but also by induction of apoptosis. Taken together, these results suggest that inhibition of CREB activity through dissociation of CREB-CREBBP by NASEp may be a potent new therapeutic in NSCLC. Citation Format: Jong Woo Lee, Hee Sun Park, Seung-Hee Ryu, Patricia Koch, Julie Boyer, Daniel Morgensztern, Roy S. Herbst, Jaseok Peter Koo. Disruption of CREB-CREBBP association by 2-Naphthol AS-E phosphate induces cell cycle arrest and apoptosis in non-small cell lung cancer cells . [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3414. doi:10.1158/1538-7445.AM2013-3414
711. Treatment of Acute Myeloid Leukemia by rAAV 8 Vector Mediated Human Interferon-β Gene Transfer
Authors: Reuben Benjamin, Andrew M. Davidoff, Pizzey Arnold, Nalini Singh, Asim Khwaja, Jenny McIntosh, Cathy C.Y. Ng, Tony Meager, Meenu Wadhwa, Amit C. Nathwani
Journal: Molecular Therapy (2005)

Alpha-interferons are widely used in the treatment of hematological malignancies such as CML, multiple myeloma and hairy cell leukemia. However their efficacy in the management of acute myeloid leukemia (AML) has not been fully evaluated. Furthermore the antitumour effects of the related |[beta]|-interferon have also not been systematically investigated in AML. Treatment with recombinant interferon is limited by its short half-life and its side effects which frequently results in failure to achieve stable therapeutic levels. We have therefore adopted a gene therapy approach using rAAV type 8 vectors to deliver sustained systemic expression of human IFN-|[beta]| invivo and evaluated the subsequent effect on tumour development in murine xenograft models using both AML cell lines as well as primary cells.
Origin of Smooth Muscle Progenitor Cells: Different Conclusions From Different Models
Authors: Masataka Sata, Kimie Tanaka, Ryozo Nagai
Journal: Circulation (2003)

We read with interest the recent article by Hu et al 1 who investigated the origin of smooth muscle cells (SMCs) in transplant atherosclerotic lesions.][4] We are concerned that such opposite conclusions are drawn using different experimental systems to test the hypothesis.Hu et al 1 used a novel mouse model of arterial transplantation.The authors grafted a donor aorta to a recipient carotid artery using the cuff technique in the absence of immunosuppressants.The pathophysiology of vasculopathy in the authors' model may differ from that of arteriosclerosis observed in immunosuppressed cardiac allografts, as many studies have suggested that immunosuppressants potentially affect the pathogenesis of transplant arteriosclerosis.By inducing 3 distinct types of mechanical vascular injuries to a single mouse, we found that recruitment of bone marrow-derived cells to vascular lesions depends largely on the type of model used (K.Tanaka and M. Sata, unpublished observation, 2002).We detected a robust contribution of bone marrow-derived cells after mechanical endovascular injury, whereas there were only a few marker-positive cells in the neointima after ligation of the common carotid artery.We seldom found bone marrow-derived cells in the lesion induced by perivascular cuff replacement.These results suggest that in certain types of models, we may underestimate the potential contribution of bone marrow cells in vascular remodeling.Furthermore, Hu et al 1 used a transgenic mouse that expresses LacZ in vascular SMCs under the transcriptional control of the SM22 promoter.Human vascular SMCs are quite heterogeneous in the expression of differentiation markers, although ␣-actin is abundantly expressed in all SMCs. 5 Thus, some ␣-actin-positive cells may not express LacZ in the transgenic mouse.Consequently, although the transgenic mice are useful to identify SMCs, they may not be adequate to identify "SMC-like cells" in the neointima.Finally, we are aware that irradiation and bone marrow transplantation have tremendous effects on many tissues, even when the blood system appears to have been reconstituted.Therefore, Hu et al 1 might have underestimated the potential contribution of bone marrow cells to graft vasculopathy.We also believe that there are other sources of smooth muscle progenitors.We suggest caution before extrapolating the conclusions provided by Hu et al to the pathogenesis of graft vasculopathy.