tbuckley/cabot-search huggingface dataset:
Current Perspectives in Allergy
Authors: Morton L. Podolsky
Journal: JAMA (1984)

British physicians coined the term "hay fever," pioneered the original concepts of allergy, and forged the foundations of treatment. Comparatively recently, their American counterparts rivaled these achievements, especially in the laboratory and field of technology. This book, the collaborative effort of British and American scientists, encompasses the best of both worlds—tradition, theory, and practice—each complementing the other. In clear, explicit, and easily read prose, the authors describe and explain the interactions of the various components of immediate and delayed hypersensitivity responses, the role of hypersensitivity reactions in the pathogenesis of allergic diseases, and the pharmacophysiology of β-adrenergic agents and methylaxanthines. The Americans concentrate on the discovery of IgE, the elucidation of the genetic determinants of IgE immune responses, and the identification of new classes of lipid and peptide mediators of immediate hypersensitivity. The British, who have not labored under Food and Drug Administration constraints, record their experiences and clinical trials
A randomized, placebo-controlled, dose-ranging study of single-dose omalizumab in patients with H1-antihistamine–refractory chronic idiopathic urticaria
Authors: Sarbjit Saini, Karin E. Rosen, Hsin-Ju Hsieh, Dennis A. Wong, Edward Conner, Allen Kaplan, Sheldon Spector, Marcus Maurer
Journal: Journal of Allergy and Clinical Immunology (2011)
Serum Electrophoretic Changes in Polymyositis
Authors: K. Gavrilescu, J. M. Small
Journal: BMJ (1962)

Twenty-seven vesico-vaginal fistulae are presented.Cephalopelvic disproportion is shown to play an important part in their causation.Treatment was by vaginal repair in 17 cases, trans- plantation of the ureters in four, and reconstruction of the anus with closure of the vaginal introitus in one case.Three patients left hospital before their treatment was finished, and the completion of treatment was not seen in two cases.
Letter: Comparison between free thyroxine index and effective thyroxine ratio.
Authors: M L Wellby, M W O'Halloran, J Marshall
Journal: BMJ (1975)

aged 24-50) were then visited without prior waring and their height and weight -easured.Their report heights and weights were on average 05 in (12-7 n) above and 6-1 lb (3'13 kg) below their actual measurements.As in Ashwell and Etchell's paper, overweight was assessed using the Metrpolitan Life Insurance Company tables.2For 90% of the women the reported measurements indicated a lower degree of overwetght than the actual measurements, the difference being roughly proportional to the degree of overweight.As well as broadly dassifying body size as either "overweight," "saitable," or "underweight" Ashwell and Etchell define categories of over-and underweight.In- dividuals 30%, 20%, and 10% above ideal weight were classed as severely, moderately, and mildly overweight respectively, with corresonding groupings for underweight.UJing these categories 15 of the 40 women in our study were classified in a lower category on reported ithan on actual meaurements.Four of these changes were fron the broad classification "overweight" to that of "suitable weight"Our data indicate that reported height and weight should be treated with great caution, as there appears to be systematic underestimation of body size.It may well be that this underestimation of body size as assessed from reported data reflects aware- ness of overweight status.We would sug- gest that any fturther studies on perception of overweight should obtain information on reported as well as actual height and weight and also perceived weight status.-Weare, etc.,
Unusual Appearance of Lingual Thyroid in Congenital Hypothyroidism
Authors: JAMES STRAIN, ELIZABETH OATES, ABDOLLAH SADEGHI-NEJAD
Journal: Clinical Nuclear Medicine (1998)

The differential diagnosis of congenital hypothyroidism includes an absent gland (athyrosis), an ectopic gland (usually lingual), or an inborn error of metabolism (dyshormonogenesis causing goiter). Thyroid scintigraphy can readily distinguish between these etiologies. Abnormalities in thyroid embryonic development and descent can result in midline thyroid tissue located from the base of the tongue to the mediastinum. Multiple ectopic sites of aberrant thyroid migration are rare, however; most ectopic rests appear as a solitary focus. Ectopic lingual thyroid tissue, although usually asymptomatic and uncomplicated, can cause local obstruction (e.g., dysphasia) or hemorrhage (e.g., hemoptysis).
Distinct MHC class I and II alleles are associated with hepatitis C viral clearance, originating from a single source
Authors: Susan M. McKiernan, Richard Hagan, Michael Curry, George S. A. McDonald, Alan Kelly, Niamh Nolan, Anne Walsh, John Hegarty, Emer Lawlor, Dermot Kelleher
Journal: Hepatology (2004)

The role of cytotoxic T lymphocyte responses, restricted by human leukocyte antigen (HLA) class I alleles, is recognized as highly significant in the successful clearance of hepatitis C virus (HCV). The frequency of class I alleles in females inoculated with HCV genotype 1b from a single source was examined for an association with outcome. Class I typing was performed using polymerase chain reaction sequence-specific primers in 227 female subjects: 141 had chronic infection and 86 had viral clearance. Statistical analysis included χ 2 testing and multiple logistic regression analysis. A*03, B*27, and Cw*01 occurred more frequently in those with viral clearance (39.5%, 14%, and 9.3%, respectively) compared with those with chronic infection (19.1%, 2.1%, and 1.4%, respectively; P ≤ .005). B*08 occurred more often in those with chronic infection compared with viral clearance (39.7% vs. 19.8%; P = .002). In combination with previously reported class II allele associations, over 75% that successfully eliminate HCV carry either A*03, DRB1*0101, or *0401, compared with only 37% of those with chronic infection ( P &lt; .0001). The haplotypes A*03-B*07-DRB1*15-DQB1*0602 and A*02-B*27-Cw*01-DRB1*0101-DQB1*0501 are associated with viral clearance ( P = .004 and .01, respectively). By multiple logistic regression analysis, the alleles A*03, B*27, DRB1*0101, *0401, and *15 are associated with viral clearance, and B*27 has the strongest association (odds ratio [OR] 7.99). The haplotype A*01-B*08-Cw*07-DRB1*03011-DQB1*0201 is associated with chronic infection ( P = .002), being independent for DQB1*0201 (OR 0.27). In conclusion , certain class I alleles are associated with outcome in this homogenous cohort. More significantly, either HLA-A*03, -DRB1*0101, or -*0401 are carried by an overwhelming majority of those subjects who successfully clear HCV. (Hepatology 2004;40:108-114.)
Interventional Electrophysiology and Cardiac Resynchronization Therapy
Authors: J. David Burkhardt, Bruce L. Wilkoff
Journal: Circulation (2007)

Implantable devices have become a readily available option for patients with heart failure. Not only do these patients develop bradycardia and ventricular tachycardia, but their ventricular dysfunction can often improve with cardiac resynchronization therapy. However, this is a complex and rapidly developing clinical science for which the physician chooses techniques and selects patients on the basis of the results of clinical trials, clinical experience, and rapidly evolving tools. The results depend on the interplay of these complex variables. Placement of the left ventricular lead has forced the device physician to develop new skills and/or interdisciplinary relationships with physicians with vascular intervention, imaging, and surgical skills. Familiarity with the cardiac venous anatomy, occlusive venography, venoplasty, guide wire tools, guiding catheters, stenting, and new intracardiac visualization and magnetic intracardiac lead positioning tools are examples of just a few of the novel skills that are useful in the delivery of cardiac resynchronization therapy. Beyond implantation, these patients and devices require specialized follow-up with continued medical therapy and echo-guided adjustments of device programming. Finally, there are ongoing controversies and many as yet unanswered questions that are the subject of ongoing and planned clinical trials.
Abstract 4561: Quantitative phosphoproteomics of an AKT inhibitor in a PTEN-LOF breast model by label free phospho-dMS demonstrates modulation of protein transcription, protein translation, and motility
Authors: An Chi, Heike Keilhack, Hongbo Guo, Kumiko Nagashima, Jannik Andersen, Cloud Paweletz, Ronald Hendrickson
Journal: Cancer Research (2010)

Abstract Among the many types of molecular mechanisms that are currently understood, none is more important for the control of cellular faith than the network of protein kinases and phosphatases. The importance of understanding these signaling networks is furthermore highlighted by the fact that virtually all major pharmaceutical companies have significant projects focused on targeted interference against oncogenic kinases as potential anti-tumor therapies. Yet, a system's wide analysis of signaling phosphorylations by these inhibitors in in vivo (i.e. tissue or xenograft models) is cost prohibitive and rarely performed. The use of mass spectrometry is a powerful approach to study complex mixtures, and some techniques have used either chemical or metabolical isotopic labeling strategies to quantify protein differences between cohorts. While these techniques have been shown to be useful and are routinely applied for cell culture systems, they do not extend readily to in vivo studies as these require either combining of samples or are dependent on the duty cycle of the mass spectrometer. Here we report a generally applicable proteomic approach to identify global protein phosphorylation changes in in-vivo systems. This label-free discovery platform, named phospho-differential mass spectrometry (phospho-dMS) does not require complex mixing or pooling strategies or isotope labeling, and instead identifies statistically significant changes in full scan mass spectrometry data. Hence, in-vivo samples can be analyzed individually, allowing the use of longitudinal designs and within-subject data analysis. We demonstrate phospho-dMS on 27 breast tumor tissues samples (3 concentrations, 3 time points, 3 mice each) excised from a PTEN-LOF mouse model. We quantified in excess of 2000 high confidence phosphorylation events. The most prominent protein modules inhibited by compound treatment (P&amp;lt;0.0001) relate to cytoskeletal machinery such as cell polarity and cytoskeletal reorganization, transcription factors, co-activators, and protein translation with known relevance to cancer. For the first time, using quantitative MS, the topology and significance of phosphorylation networks may be investigated in xenograft, GEM models, and tumor tissue samples marking a new era of cancer signaling research Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4561.
Genome-wide association study identifies two new susceptibility loci for atopic dermatitis in the Chinese Han population
Authors: Liang-Dan Sun, Feng-Li Xiao, Yang Li, Wen-Ming Zhou, Hua-Yang Tang, Xian-Fa Tang, Hui Zhang, Heidi Schaarschmidt, Xian-Bo Zuo, Regina Foelster-Holst, Su-Min He, Mei Shi, Qiang Liu, Yong-Mei Lv, Xi-Lan Chen, Kun-Ju Zhu, Yi-Feng Guo, Da-Yan Hu, Ming Li, Min Li, Yan-Hong Zhang, Xin Zhang, Jian-Ping Tang, Bi-Rong Guo, Hua Wang, Yuan Liu, Xiao-Yan Zou, Fu-Sheng Zhou, Xiao-Yan Liu, Gang Chen, Lin Ma, Shu-Mei Zhang, Ai-Ping Jiang, Xiao-Dong Zheng, Xing-Hua Gao, Pan Li, Cai-Xia Tu, Xian-Yong Yin, Xiu-Ping Han, Yun-Qing Ren, Shun-Peng Song, Zhi-Yong Lu, Xing-Lian Zhang, Yong Cui, Jing Chang, Min Gao, Xiao-Yan Luo, Pei-Guang Wang, Xing Dai, Wei Su, Hui Li, Chun-Pin Shen, Sheng-Xiu Liu, Xiao-Bo Feng, Chun-Jun Yang, Guo-Shu Lin, Zai-Xing Wang, Jian-Qing Huang, Xing Fan, Yan Wang, Yi-Xiao Bao, Sen Yang, Jian-Jun Liu, Andre Franke, Stephan Weidinger, Zhi-Rong Yao, Xue-Jun Zhang
Journal: Nature Genetics (2011)
Stroke Increase Reported in HIV Patients
Authors: Rebecca Voelker
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Persistence of antibody after accelerated immunisation with diphtheria/tetanus/pertussis vaccine.
Authors: M E Ramsay, M J Corbel, K Redhead, L A Ashworth, N T Begg
Journal: BMJ (1991)

To determine the persistence of antibody to diphtheria, tetanus, and pertussis in children receiving an accelerated schedule of primary immunisation.Controlled study of antibody testing of blood samples from children immunised according to various schedules: three doses of triple vaccine completed at 8-13 calendar months, 6-7 calendar months, before 6 calendar months, or three doses followed by diphtheria/tetanus before age 2.Plymouth Health Authority.129 children aged 4 years who had received three doses of diphtheria/tetanus/pertussis vaccine with or without a diphtheria/tetanus booster.Diphtheria and tetanus antitoxin concentrations and antibody titres to pertussis toxin, filamentous haemagglutinin, and agglutinogens 2 and 3.All children had protective concentrations of antitoxin to diphtheria and tetanus (greater than or equal to 0.01 IU/ml). There was no evidence of a significant difference in diphtheria or tetanus antitoxin concentrations and pertussis antibody titres in children immunised with an accelerated course (third dose of triple vaccine before 6 months) compared with those who received a longer course (third dose at 8-13 months) with no booster (geometric mean antitoxin concentration 0.411 (95% confidence interval 0.273 to 0.618) v 0.426 (0.294 to 0.616) for diphtheria and 0.358 (0.231 to 0.556) v 0.299 (0.197 to 0.453) for tetanus; geometric mean antibody titres 903 (500 to 1631) v 1386 (848 to 2266) for pertussis filamentous haemagglutinin, 179 (130 to 248) v 232 (167 to 322) for pertussis toxin, and 2002 (1276 to 3142) v 3591 (2220 to 5809) for agglutinogens 2 and 3).Immunisation with three doses of triple vaccine at monthly intervals completed before 6 months of age probably provides adequate protection against diphtheria, tetanus, and whooping cough which will persist until the age of the preschool booster.
Primary Care as Part of US Health Services Reform-Reply
Authors: Barbara Starfield
Journal: JAMA (1993)

In Reply.  —Dr Barkun and Ms Ryten confirm that provinces in Canada restrict the issuing of licenses to practice. It was not our intent to suggest that academic centers do this, only that it would not be in their interest to produce physicians who would be unable to obtain licenses.  Dr Godfrey's comments are well taken. In some countries, specialists are not paid, or are paid less, if they see a patient without a referral from a primary care provider. Her point about provision of primary care by physician extenders might be broadened; primary care needs to be recognized as an important and intellectually challenging discipline that merits superb training, whatever the type of practitioner.  Dr Goodman argues for the inclusion of dentistry as a primary care discipline. We believe that turf warfare between health-related disciplines is counterproductive in our quest to achieve a highly effective health care system. Primary
Thrombotic thrombocytopenic purpura?hemolytic uremic syndrome (TTP-HUS) following treatment with deoxycoformycin in a patient with cutaneous T-cell lymphoma (Sezary syndrome): A case report
Authors: Joseph W. Leach, Trinh Pham, Dimitris Diamandidis, James N. George
Journal: American Journal of Hematology (1999)

We present a case of a patient who developed all manifestations of thrombotic thrombocytopenic purpura-hemolytic uremic syndrome (TTP-HUS) acutely following treatment of cutaneous T-cell lymphoma (CTCL, Sezary syndrome) with deoxycoformycin (pentostatin). Symptoms and signs included severe thrombocytopenia and microangiopathic hemolytic anemia; hallucinations, confusion and disorientation; oliguric acute renal failure requiring hemodialysis; and fever. No other etiology for these symptoms and signs was present. Complete recovery followed treatment for one month with plasma exchange and glucocorticoids. During the succeeding 20 months she has remained well and her CTCL remains stable on no further treatment. This case and two previously published cases suggest that acute and severe TTP-HUS may be a dose-dependent toxicity of deoxycoformycin (pentostatin). Am. J. Hematol. 61:268–270, 1999. © 1999 Wiley-Liss, Inc.
Ticagrelor Compared With Clopidogrel by Geographic Region in the Platelet Inhibition and Patient Outcomes (PLATO) Trial
Authors: Kenneth W. Mahaffey, Daniel M. Wojdyla, Kevin Carroll, Richard C. Becker, Robert F. Storey, Dominick J. Angiolillo, Claes Held, Christopher P. Cannon, Stefan James, Karen S. Pieper, Jay Horrow, Robert A. Harrington, Lars Wallentin
Journal: Circulation (2011)

Background— In the Platelet Inhibition and Patient Outcomes (PLATO) trial, a prespecified subgroup analysis showed a significant interaction between treatment and region ( P =0.045), with less effect of ticagrelor in North America than in the rest of the world. Methods and Results— Reasons for the interaction were explored independently by 2 statistical groups. Systematic errors in trial conduct were investigated. Statistical approaches evaluated the likelihood of play of chance. Cox regression analyses were performed to quantify how much of the regional interaction could be explained by patient characteristics and concomitant treatments, including aspirin maintenance therapy. Landmark Cox regressions at 8 time points evaluated the association of selected factors, including aspirin dose, with outcomes by treatment. Systematic errors in trial conduct were ruled out. Given the large number of subgroup analyses performed and that a result numerically favoring clopidogrel in at least 1 of the 4 prespecified regions could occur with 32% probability, chance alone cannot be ruled out. More patients in the United States (53.6%) than in the rest of the world (1.7%) took a median aspirin dose ≥300 mg/d. Of 37 baseline and postrandomization factors explored, only aspirin dose explained a substantial fraction of the regional interaction. In adjusted analyses, both Cox regression with median maintenance dose and landmark techniques showed that, in patients taking low-dose maintenance aspirin, ticagrelor was associated with better outcomes compared with clopidogrel, with statistical superiority in the rest of the world and similar outcomes in the US cohort. Conclusions— The regional interaction could arise from chance alone. Results of 2 independently performed analyses identified an underlying statistical interaction with aspirin maintenance dose as a possible explanation for the regional difference. The lowest risk of cardiovascular death, myocardial infarction, or stroke with ticagrelor compared with clopidogrel is associated with a low maintenance dose of concomitant aspirin. Clinical Trial Registration— URL: http://www.clinicaltrials.gov . Unique identifier: NCT00391872.
RELATION OF THE PUBLIC SCHOOL TO THE SEMINARY AND COLLEGE AS TO PSYCHOSES.
Authors: F. SAVARY PEARCE
Journal: JAMA (1903)

This topic is an important one to the educator and to the parent or guardian of the growing youth of our fair land, America, which claims so justly to be a leader in earthly pursuits. That we are going a little too rapidly toward progression of the mind in these almost too strenuous days of advancement is pretty clear to the thinker or man of larger experience. The result of "wear and tear" on the nervous system must be remembered to be much greater in youths from 14 to 18 years, i. e., during the development of adolescence with its wonderful attendant physiologic, physical and psychic readjustment of the organization. The paper written on this subject must not include as a fundamental basis for study the hardy westerners' children of the plains, nor the country school boy who is forced to healthy physical exercise in his trudging along the country
Robot-assisted Sacrocolpopexy for Pelvic Organ Prolapse: A Systematic Review and Meta-analysis of Comparative Studies
Authors: Maurizio Serati, Giorgio Bogani, Paola Sorice, Andrea Braga, Marco Torella, Stefano Salvatore, Stefano Uccella, Antonella Cromi, Fabio Ghezzi
Journal: European Urology (2014)
Stokes-Adams Attacks Complicating Acute Myocardial Infarction
Authors: Henry H. Gale, Henri L. Enfroy
Journal: New England Journal of Medicine (1959)

THE classic therapy for Stokes-Adams seizures has A long been the epinephrinelike drugs, administered orally or parenterally.1 Epinephrine may relieve such seizures by ventricular acceleration after diminution of the grade of atrioventricular block or by direct stimulation of an idioventricular pacemaker. Before epinephrine is used, however, it is important to determine that the syncope is due to asystole or bradycardia rather than abnormal ventricular rhythm of a prefibrillatory type in which epinephrine may precipitate fatal ventricular fibrillation.Both atrial and ventricular rates are increased by epinephrine in complete heart block. The effect on the rate of the atrial contraction bears . . .
Optimizing Health for Persons With Multiple Chronic Conditions
Authors: Anand K. Parekh, Richard Kronick, Marilyn Tavenner
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal