tbuckley/cabot-search huggingface dataset:
Dynamic metal-thiolate cluster structure of metallothioneins.
Authors: M Vasák
Journal: Environmental Health Perspectives (1986)

113Cd-NMR studies have established that vertebrate and invertebrate metallothioneins contain two unique metal-thiolate clusters. However, it proved to be difficult to account theoretically for all features of the 113Cd-NMR spectra. In a reinvestigation of these features using chromatographically homogeneous 113Cd7-metallothionein we have identified a total of seven 113Cd resonances and have confirmed the massive intensity difference among these signals. From the effects of variations in temperature, ionic strength, and magnetic field on one-dimensional 113Cd-NMR spectra and from two-dimensional J-resolved 113Cd-NMR spectrum it was concluded that the seven 113Cd signals are composed of several overlapping multiplets and indicative of a dynamic organization of the metal-thiolate clusters. The same nonrigid structure is also indicated individually by recent two-dimensional correlated (COSY) 1H-NMR studies of 113Cd7-metallothionein. While showing 113Cd-1H coupling for 19 of the 20 cysteine residues, these studies have evidence for only two "bridging" cysteine ligands of the clusters instead of the expected eight suggesting interferences by metal-thiolate exchange process at the 1H-NMR time scale. Analogous indirect evidence for structural mobility of the clusters comes from EXAFS measurements of Zn7-metallothionein and from measurements of the perturbed angular correlation of gamma-rays (PAC) emis-sion of 111mCd-metallothionein. Thus, while the EXAFS spectra revealed back-scattering from the thiolate ligands, lattice movements within the cluster is believed to preclude back-scattering from neighboring metals. Similarly, in the PAC time spectra the damping of the major oscillatory component was attributed to inordinately large charge fluctuation in the immediate environment of the 111mCd nucleus.(ABSTRACT TRUNCATED AT 250 WORDS)
Amputation for pseudotumour in acquired haemophilia.
Authors: N J Treble, N J Henderson, H Dasani
Journal: BMJ (1984)

Age groupAge specific ovarian cyst hospital discharge rates (per 100 000 women per year).The percentages are the % change between 1962 and 1964 and between 1977 and 1979 rates.We thank Dr J Ashley of the Office of Population Censuses and Surveys for providing unpublished HIPE tables.
A Genomic Region Evolving Toward Different GC Contents in Humans and Chimpanzees Indicates a Recent and Regionally Limited Shift in the Mutation Pattern
Authors: I. Ebersberger
Journal: Molecular Biology and Evolution (2005)

DNA sequences evolving differently in the human and chimpanzee genomes signal recent and regionally limited changes in the process of DNA sequence evolution. Here we present the comparison of 90 kb from the nonrecombining part of the human Y chromosome to the corresponding part of the chimpanzee genome using gorilla as out-group. Our results reveal a significant difference in the region-specific substitution process among the human and chimpanzee lineages. As a consequence, this region experiences a change in its GC content on the human lineage while it resides in compositional equilibrium on the chimpanzee lineage. Based on our analysis, we suggest a recent and species-specific shift in the region's mutation pattern as the cause of its differing evolution in humans and chimpanzees.
Determinants of pulmonary blood volume
Authors: Milena L. Lewis, Julian Gnoj, Vincent J. Fisher, Lynn C. Christianson
Journal: Journal of Clinical Investigation (1970)

Pulmonary blood volume was determined by the radiocardiographic technique in 49 patients coming to cardiac catheterization. Since this method has not been directly compared with the more commonly used double injection of dye. 25 comparisons were carried out in 13 patients of the series. Agreement was good over a range of 4.5-21.1 heart cycles since there was no statistically significant difference between transit time values measured by the two methods. The relation of pulmonary blood volume to other hemodynamic factors in these 49 patients, with and without cardiac or pulmonary disease, was evaluated by means of multiple regression analysis. The analysis carried out for mean transit time indicates that this parameter varies predominately with flow. Pulmonary blood volume, in this series of resting recumbent individuals, varies to a significant degree only with total blood volume and with pulmonary venous pressure. No parameters of vascular distensibility, such as pulmonary vascular resistance, were found to affect the volume of blood in the lungs. The fact that variations in pulmonary blood volume among the subjects could be described by a multiple regression equation linear with respect to total blood volume and pulmonary venous pressure indicates that these variations are the result of passive distention of components of the vascular bed.
Measuring the performance of screening tests
Authors: P. Sedgwick
Journal: BMJ (2014)

Researchers assessed the performance of the SCOFF questionnaire as a screening tool in primary care for eating disorders. The questionnaire consists of five questions related to the core features of anorexia nervosa and bulimia nervosa. The study participants were 341 consecutive female attendees aged 18-50 years at two general practices. All women completed the SCOFF questionnaire and underwent a clinical diagnostic interview. If a woman responded “yes” to two or more of the five questions on the SCOFF questionnaire she was identified as “positive” and at “high risk” of eating disorders; otherwise she was identified as “negative” and at “low risk” of eating disorders. A diagnosis of eating disorders was confirmed through a clinical diagnostic interview for eating disorders based on criteria from the Diagnostic and Statistical Manual of Mental Disorders (fourth edition).1

The SCOFF questionnaire had a sensitivity of 84.6%, specificity of 89.6%, positive predictive value of 24.4%, and negative predictive value of 99.3%.

Which of the following statements, if any, are true?

Statements a , b , c , and d are all true.

It would be impractical for all women in primary care to have a clinical diagnostic interview for eating disorders. Not only would this be time consuming and expensive, but it would probably be inconvenient and unnecessary for most women. …
Reconnecting data analysis and research design: Who needs a confidence interval?
Authors: Andrew F. Hayes
Journal: Behavioral and Brain Sciences (1998)

Chow illustrates the important role played by significance testing in the evaluation of research findings. Statistics and the goals of research should be treated as both interrelated and separate parts of the research evaluation process – a message that will benefit all who read Chow's book. The arguments are especially pertinent to the debate over the relative merits of confidence intervals and significance tests.
Effects of Enalapril in Insulin-Dependent Diabetic Subjects With Mild to Moderate Uncomplicated Hypertension
Authors: Philippe Passa, Hervé LeBlanc, Michel Marre
Journal: Diabetes Care (1987)

The antihypertensive efficacy of enalapril and its effects on the metabolism and kidney function were investigated in 11 insulin-dependent diabetic subjects with uncomplicated mild to moderate hypertension. During a short-term single-blind controlled trial, one daily dose of 20 or 40 mg enalapril significantly reduced both systolic and diastolic blood pressure. In the supine position, mean systolic blood pressure declined from 169 +/- 6 to 142 +/- 6 mmHg (P less than .01) and mean diastolic blood pressure from 101 +/- 1.5 to 85 +/- 2 mmHg (P less than .001). No changes in heart rate or postural hypotension were observed. During 1 yr of treatment, the antihypertensive efficacy of enalapril did not decline, and no clinical side effects were observed. Inhibition by enalapril of angiotensin-converting enzyme did not modify daily insulin requirements, glycemic control, uricemia, or lipid metabolism; kalemia and the markers of diabetic nephropathy were not significantly altered. These results suggest that enalapril once daily should be used as the first step in the treatment of diabetic patients with mild to moderate hypertension.
Phylostratigraphic Bias Creates Spurious Patterns of Genome Evolution
Authors: Bryan A. Moyers, Jianzhi Zhang
Journal: Molecular Biology and Evolution (2014)

Phylostratigraphy is a method for dating the evolutionary emergence of a gene or gene family by identifying its homologs across the tree of life, typically by using BLAST searches. Applying this method to all genes in a species, or genomic phylostratigraphy, allows investigation of genome-wide patterns in new gene origination at different evolutionary times and thus has been extensively used. However, gene age estimation depends on the challenging task of detecting distant homologs via sequence similarity, which is expected to have differential accuracies for different genes. Here, we evaluate the accuracy of phylostratigraphy by realistic computer simulation with parameters estimated from genomic data, and investigate the impact of its error on findings of genome evolution. We show that 1) phylostratigraphy substantially underestimates gene age for a considerable fraction of genes, 2) the error is especially serious when the protein evolves rapidly, is short, and/or its most conserved block of sites is small, and 3) these errors create spurious nonuniform distributions of various gene properties among age groups, many of which cannot be predicted a priori. Given the high likelihood that conclusions about gene age are faulty, we advocate the use of realistic simulation to determine if observations from phylostratigraphy are explainable, at least qualitatively, by a null model of biased measurement, and in all cases, critical evaluation of results.
Renal Artery Thrombosis: Systemic Contraceptive-Induced or Spontaneous?
Authors: JESUS MONTOLIU
Journal: Annals of Internal Medicine (1979)

Letters1 October 1979Renal Artery Thrombosis: Systemic Contraceptive-Induced or Spontaneous?JESUS MONTOLIU, M.D.JESUS MONTOLIU, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-91-4-657_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In the June issue, Dr. Golbus and colleagues report a case of renal artery thrombosis secondary to oral contraceptives (1). It is not my intention to question the relation between such medication and the development of thrombosis, but I wish to comment on the author's statement that spontaneous renal artery thrombosis has not been previously described in the absence of trauma, anatomic abnormalities, or predisposing illnesses such as polycythemia or thromboangiitis obliterans.Two cases of spontaneous renal artery thrombosis were reported in 1973 by Walsh and associates (2). No predisposing factors were present, and histopathologic examination of...References1. GOLBUSSWERDLINMITASROWLEYJAMES SAJWD. Renal artery thrombosis in a young woman taking oral contraceptives. Ann Intern Med. 1979;90:939-40. LinkGoogle Scholar2. WALSHO'SULLIVANHANSON AGJ. Renal artery thrombosis. Br J Urol. 1973;45:578-80. CrossrefMedlineGoogle Scholar3. MONTOLIUBOTEYTORRASDARNELLREVERT JAAAL. Renin-induced massive proteinuria in man. Clin Nephrol. 1979;11:267-71. MedlineGoogle Scholar4. MAGILLIGANDEWEESEMAYROB DJAC. The occluded renal artery. Surgery. 1975;78:730-8. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Toronto Western Hospital Toronto, ON M5T 2S8 Canada PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1979Volume 91, Issue 4Page: 657-657KeywordsOral contraceptive therapyPolycythemiaRenal arteriesThrombosis Issue Published: 1 October 1979 PDF downloadLoading ...
Enzalutamide — A Major Advance in the Treatment of Metastatic Prostate Cancer
Authors: Nicholas J. Vogelzang
Journal: New England Journal of Medicine (2012)

In this issue of the Journal, Scher et al. describe the strikingly positive results of a phase 3 trial of a new nonsteroidal antiandrogen agent, enzalutamide, as compared with placebo in metastatic castration-resistant prostate cancer.1 Not only was survival significantly improved among patients who had undergone previous chemotherapy with docetaxel (a treatment that is a watershed event in the lives of most patients), but the incidence of adverse events of grade 3 or higher was lower among the patients receiving enzalutamide than among those receiving placebo (a finding that suggests that the "toxicity" of placebo is related to underlying disease-related . . .
Exercise-Related Ventricular Premature Complexes in Coronary Heart Disease
Authors: RICHARD H. HELFANT
Journal: Annals of Internal Medicine (1974)

This study correlates the presence of exercise-related ventricular premature complexes with both exercise-induced ST-segment depression and coronary arteriographic and ventriculographic findings in 60 patients evaluated for chest pain. Of 38 patients in whom ventricular premature complexes were either precipitated or increased with exercise, 22 had coronary disease, 10 showed a cardiomyopathy, and 6 were normal. Twelve of the 22 coronary patients had 3-vessel disease, 6 had 2-vessel disease and 4 had 1-vessel disease. Sixteen of these 22 also showed coronary collaterals and left ventricular contraction abnormalities (asynergy). Twenty of the 22 showed ≥2 mm ST-segment depression with exercise, in addition to the ventricular premature complexes (P < 0.001). Twenty-two patients showed a decrease in ventricular premature complexes with exercise. Six had coronary disease, eight had a cardiomyopathy, and eight were normal. None of the six with coronary disease had 3-vessel disease, two had 2-vessel disease, and four had disease of 1 vessel. Collaterals and asynergy were found in one of the six patients. None of the patients in this group showed ST-segment depression with exercise.
Married women have lower risk of dying from heart disease than single women, says UK study
Authors: J. Wise
Journal: BMJ (2014)

Women who are married or living with a partner have a similar risk of developing ischaemic heart disease to unmarried women but a substantially lower risk of dying from it, data from the Million Women cohort have shown.1

Being married has been associated with lower mortality from heart disease in men in some studies, but there has been less evidence of an association among women.

The …
Topical vitamin D3 derivatives for recalcitrant warts in three immunocompromised patients
Authors: K. Egawa, T. Ono
Journal: British Journal of Dermatology (2004)

Journal Article Topical vitamin D3 derivatives for recalcitrant warts in three immunocompromised patients Get access K. Egawa, K. Egawa Department of Dermatology, Kumamoto University School of Medicine, 1‐1‐1 Honjo, 860‐0811 Kumamoto, Japan E‐mail: kuroibo@kaiju.medic.kumamoto‐u.ac.jp Search for other works by this author on: Oxford Academic Google Scholar T. Ono T. Ono Department of Dermatology, Kumamoto University School of Medicine, 1‐1‐1 Honjo, 860‐0811 Kumamoto, Japan E‐mail: kuroibo@kaiju.medic.kumamoto‐u.ac.jp Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 150, Issue 2, 1 February 2004, Pages 374–376, https://doi.org/10.1111/j.1365-2133.2003.05766.x Published: 01 February 2004
A Question About Smoking
Authors: Cuthbert Tunstall
Journal: JAMA (1965)

<h3>To the Editor:—</h3> There is statistical evidence that pulmonary carcinoma is more likely to occur in cigarette smokers than in nonsmokers or smokers of cigars or pipes. There is also statistical evidence that in two rather large groups of people in England, who had comparable smoking habits, carcinoma of the lung was much more common among those who lived in London amid the fumes of burning petroleum than among those who lived in a rural environment. I think that it was during or about the time of World War II, that manufacturers began the production of really practical cigarette lighters which burn petroleum products. At about that time the lighters came into extensive use. It was also since then that the vociferous minority of nonsmokers began to pile up their anticigarette statistics. From the nature of their smokes, cigarette smokers have to light their smokes more often than cigar smokers.
Cutaneous Langerhans cell histiocytosis in an elderly man successfully treated with narrowband ultraviolet B
Authors: S. Imafuku, S. Shibata, A. Tashiro, M. Furue
Journal: British Journal of Dermatology (2007)

Journal Article Cutaneous Langerhans cell histiocytosis in an elderly man successfully treated with narrowband ultraviolet B Get access S. Imafuku, S. Imafuku Division of Dermatology, Kitakyushu Medical Center, Kitakyushu, JapanDepartment of Dermatology, School of Medicine, Fukuoka University, 45‐1 Nanakuma, Fukuoka City 814‐0180, Japan Search for other works by this author on: Oxford Academic Google Scholar S. Shibata, S. Shibata Division of Dermatology, Kitakyushu Medical Center, Kitakyushu, Japan Search for other works by this author on: Oxford Academic Google Scholar A. Tashiro, A. Tashiro Division of Dermatology, Kitakyushu Medical Center, Kitakyushu, Japan Search for other works by this author on: Oxford Academic Google Scholar M. Furue M. Furue Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan E‐mail: dermatologist@mac.com Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 157, Issue 6, 1 December 2007, Pages 1277–1279, https://doi.org/10.1111/j.1365-2133.2007.08204.x Published: 01 December 2007
Sympathetic neurotransmission in the Watanabe heritable hyperlipidaemic rabbit mesentery artery
Authors: A L Stewart-Lee, J Aberdeen, G Burnstock
Journal: Cardiovascular Research (1991)

Study objective — The aim was to examine sympathetic neurotransmission in the mesenteric artery of atherosclerotic (Watanabe heritable hyperlipidaemic, WHHL) rabbits. Design — Contractile responses to perivascular nerve stimulation (8-64 Hz) and exogenous application of the cotransmitters noradrenaline (0.1-100 μM) and adenosine triphosphate (1 μM) were measured. Catecholamine containing nerves were localised using fluorescence histochemistry. Experimental material — Female WHHL rabbits at 4, 6, and 12 months of age were used, with New Zealand white (NZW) rabbits as controls. Measurements and main results — The contractile responses to nerve stimulation were significantly smaller in 12 month old WHHL compared to NZW rabbits, although there was no difference at 4 and 6 months of age. Contractile responses of WHHL vessels to noradrenaline (0.1-100 μM) were greater than NZW controls at 4 months, but no differences were seen at 6 and 12 months. Contractile responses to α, β-methylene ATP (0.1 μM) were greater in WHHL rabbits at 6 months but were unchanged at 4 and 12 months. There was no difference in the contractile responses to potassium chloride (120 mM) between 4,6, and 12 month old WHHL and NZW rabbits. There was no variation in either strain of rabbit in the density of catecholamine containing nerves between 4 and 12 months of age. Conclusions — The reduction of sympathetic neurotransmission in WHHL rabbits at 12 months of age may largely be due to a reduction in the release of the cotransmitters noradrenaline and ATP. The reduced contractile response to nerve stimulation in 12 month old WHHL rabbits is discussed in terms of "protection" of the mesenteric artery from potential vasopasm and atherogenesis.
Reconsideration of echocardiographic standards for mitral valve prolapse: Lack of association between leaflet displacement isolated to the apical four chamber view and independent echocardiographic evidence of abnormality
Authors: Robert A Levine, Evagelos Stathogiannis, John B Newell, Pamela Harrigan, Arthur E Weyman
Journal: Journal of the American College of Cardiology (1988)
890-2 Initial results from the substrate mapping and ablation in sinus rhythm to halt ventricular tachycardia trial (SMASH VT)
Authors: Vivek Y Reddy, Allison W Richardson, Petr Neuzil, Krit Jongnarangsin, Stepan Kralovec, Lucie Sediva, Milos Taborsky, Matt Reynolds, Mark E Josephson
Journal: Journal of the American College of Cardiology (2004)
Plasma polyunsaturated fatty acid profile and delta-5 desaturase activity are altered in patients with type 2 diabetes
Authors: Satoshi Imamura, Tomoaki Morioka, Yuko Yamazaki, Ryutaro Numaguchi, Hiromi Urata, Koka Motoyama, Katsuhito Mori, Shinya Fukumoto, Tetsuo Shoji, Masanori Emoto, Masaaki Inaba
Journal: Metabolism (2014)
Delivering Care to Long-Term Adult Survivors of Hematopoietic Cell Transplantation
Authors: Karen L. Syrjala, Paul J. Martin, Stephanie J. Lee
Journal: Journal of Clinical Oncology (2012)

This review highlights long-term and late consequences of hematopoietic cell transplantation (HCT) as well as strategies to manage or prevent complications that are more prevalent after HCT than most other cancer treatments. Chronic graft-versus-host disease stands out as a unique late effect of allogeneic HCT that is not seen after other types of cancer treatment. However, many other complications seen after solid tumor treatments are also common after HCT, including infections, second cancers, bone loss, and cardiovascular, pulmonary, renal, and endocrine dysfunction. Symptoms and syndromes that are reported after HCT include sexual dysfunction, cognitive problems, fatigue, insomnia, musculoskeletal symptoms, emotional distress, anger, and depression. Addressing these complex potential or actual complications requires diligent routine health care to intervene early or, when possible, to prevent late complications. To accomplish early detection and prevention of life-threatening complications, HCT survivors should undergo an annual comprehensive physical examination that includes screening for functional and psychosocial consequences of treatment and encouraging healthy lifestyle behaviors. Clinicians can link survivors to numerous online, print, and video resources to help them advocate for their health needs.
Marital Changes After Intestinal Bypass Surgery
Authors: John R. Neill
Journal: JAMA (1978)

A retrospective interview study was undertaken of 14 spousal pairs in which one member had undergone the intestinal bypass procedure for massive obesity. Much unanticipated marital discord occurred. Sexual problems were particularly troublesome and affected both members in the spousal pairs. The results point to the role of massive obesity as a selective and stabilizing factor in the marriages of this subset of overweight persons.