tbuckley/cabot-search huggingface dataset:
Osteonecrosis of the Jaw Related to Bevacizumab
Authors: Cherry L. Estilo, Monica Fornier, Azeez Farooki, Diane Carlson, George Bohle, Joseph M. Huryn
Journal: Journal of Clinical Oncology (2008)

Osteonecrosis of the Jaw Related to BevacizumabA 51-year-old female with history of infiltrating ductal carcinoma of the right breast was diagnosed in late 2001 and treated with mastectomy in February 2002.She was subsequently treated with adjuvant chemotherapy with doxorubicin and cyclophosphamide for four cycles followed by hormonal therapy with letrozole for three years.She was diagnosed with a chest wall recurrence, involving the soft tissues in the right axillary and supra-clavicular areas in early 2006 and underwent six cycles of chemotherapy with albumin-bound nanoparticle-paclitaxel.She subsequently underwent a chest wall resection in September 2006, followed by radiation to the chest wall.She started capecitabine at the dose of 1000 mg twice a day, two weeks on and one week off, in October 2006 (in concurrence with radiation therapy to the chest wall).In December 2006, the dose of capecitabine was increased to 1500 mg AM and 1000 mg PM, also two weeks on and one week off.Bevacizumab was also started in late December 2006 at the dose of 15 mg/kg for 3 weeks for a total of 8 doses, the last one in May 2007.Six weeks following the last dose of bevacizumab, the patient presented with a 2-month history of complaints of lower jaw discomfort and what the she described as protruding bone in the lower jaw.The patient denied any recent history of dental or oral surgery.Examination revealed a small area of bone exposure in the left posterior lingual mandible, measuring approximately 1 ϫ 1 mm in diameter.The bone appeared necrotic.The surrounding soft tissue appeared normal with no evidence of infection.The rest of the oral and dental examination was unremarkable.The exposed bone was smoothed with a bone file.The patient was prescribed chlorhexidine 0.12% oral rinse.Bevacizumab and capecitabine were discontinued.A few weeks later, the area of exposed bone had resolved.The overlying mucosa appeared normal.However, there was now a new area of 1 ϫ 1 mm exposed bone in the right posterior lingual mandible (Fig 1A).The bone was mobile and was easily removed.Histological examination of the bony specimen (Fig 1B ) showed devitalized, necrotic bone (NB, black arrowhead) demonstrating a scalloped, "moth-eaten" appearance.Bacterial colonies occupied those areas in which there was loss of mineralized bone.Also
Hominin infant decentration hypothesis: Mirror neurons system adapted to subserve mother-centered participation
Authors: Stein Braten
Journal: Behavioral and Brain Sciences (2004)

Falk's hominin mother-infant model presupposes an emerging infant capacity to perceive and learn from afforded gestures and vocalizations. Unlike back-riding offspring of other primates, who were in no need to decenter their own body-centered perspective, a mirror neurons system may have been adapted in hominin infants to subserve the kind of (m)other-centered mirroring we now see manifested by human infants soon after birth.
Comparing Inhaled Ultrafine versus Fine Zinc Oxide Particles in Healthy Adults
Authors: William S. Beckett, David F. Chalupa, Andrea Pauly-Brown, Donna M. Speers, Judith C. Stewart, Mark W. Frampton, Mark J. Utell, Li-Shan Huang, Christopher Cox, Wojciech Zareba, Günter Oberdörster
Journal: American Journal of Respiratory and Critical Care Medicine (2005)

Zinc oxide is a common, biologically active constituent of particulate air pollution as well as a workplace toxin. Ultrafine particles (< 0.1 microm diameter) are believed to be more potent than an equal mass of inhaled accumulation mode particles (0.1-1.0 microm diameter).
Why doctors should get a life
Authors: Charles Foster
Journal: Journal of the Royal Society of Medicine (2009)

Everybody says that proper medicine is holistic medicine. And surely that is right. A proper doctor doesn't just treat a problem; he treats a person who happens to have a problem. He treats a mind-body-spirit unity. In this respect, doctors are unique among professionals. An accountant discharges his responsibility by getting the bottom line of the balance sheet right. A lawyer discharges his obligation by writing a legally impeccable opinion. But a doctor who treats a diseased kidney rather than the possessor of the diseased kidney is a bad doctor. A good nephrologist is a first-rate GP who knows a lot about kidneys.
Silica Particles Enhance Peripheral Thrombosis
Authors: Abderrahim Nemmar, Benoit Nemery, Peter H. M. Hoet, Nico Van Rooijen, Marc F. Hoylaerts
Journal: American Journal of Respiratory and Critical Care Medicine (2005)

Inflammation and thrombosis are related via interactions between leukocytes, platelets, the vasculature, and the coagulation system. However, the mechanisms behind these interactions remain poorly understood.We have investigated the effects of the well known pulmonary inflammation induced by silica for the development of peripheral thrombogenicity in a hamster model of thrombosis. In addition, the consequences of pulmonary macrophage and circulating monocyte and neutrophil depletion on the thrombogenicity were investigated.Silica particles (2-200 mug/hamster) were intratracheally instilled, and experimental thrombosis in photochemically induced femoral vein lesions was assessed 24 hours later, in association with cellular infiltration in the lung.Intratracheally instilled silica particles (20 and 200 mug/hamster) triggered pulmonary inflammation, together with stimulation of peripheral platelet-rich thrombus formation. Both the selective depletion of lung macrophages by intratracheal administration of clodronate liposomes and the combined depletion of circulating monocytes and neutrophils by intraperitoneal injection of cyclophosphamide significantly reduced silica-induced influx of macrophages and neutrophils in bronchoalveolar lavage, and reduced peripheral thrombogenicity. Silica-induced lung inflammation was accompanied by increased neutrophil elastase levels in bronchoalveolar lavage and in plasma. Specific neutrophil elastase inhibition in the lung did not affect lung inflammation but reduced peripheral thrombogenicity.These findings uncover pulmonary macrophage-neutrophil cross-talk releasing neutrophil elastase into the blood circulation. Elastase, triggering activation of circulating platelets, may then predispose platelets to initiate thrombotic events on mildly damaged vasculature.
Evidence for and Characterization of Suppressor Cells in BALB/c Mice Bearing ADJ-PC5 Plasmacytomas&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: M. L. Padarathslngh, J. H. Dean, T. R. Jerrels, J. L. McCoy, D. D. Lewis, J. W. Northing
Journal: JNCI Journal of the National Cancer Institute (1979)

Journal Article Evidence for and Characterization of Suppressor Cells in BALB/c Mice Bearing ADJ-PC5 Plasmacytomas Get access M. L. Padarathslngh, M. L. Padarathslngh Search for other works by this author on: Oxford Academic PubMed Google Scholar J. H. Dean, J. H. Dean Search for other works by this author on: Oxford Academic PubMed Google Scholar T. R. Jerrels, T. R. Jerrels Search for other works by this author on: Oxford Academic PubMed Google Scholar J. L. McCoy, J. L. McCoy Search for other works by this author on: Oxford Academic PubMed Google Scholar D. D. Lewis, D. D. Lewis Search for other works by this author on: Oxford Academic PubMed Google Scholar J. W. Northing J. W. Northing Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 62, Issue 5, May 1979, Pages 1235–1241, https://doi.org/10.1093/jnci/62.5.1235 Published: 01 May 1979 Article history Received: 23 May 1978 Accepted: 31 October 1978 Published: 01 May 1979
Chronic Care Clinics for Diabetes in Primary Care
Authors: Edward H. Wagner, Louis C. Grothaus, Nirmala Sandhu, Mary Sue Galvin, Mary McGregor, Karen Artz, Eric A. Coleman
Journal: Diabetes Care (2001)

OBJECTIVE—To evaluate the impact of primary care group visits (chronic care clinics) on the process and outcome of care for diabetic patients. RESEARCH DESIGN AND METHODS—We evaluated the intervention in primary care practices randomized to intervention and control groups in a large-staff model health maintenance organization (HMO). Patients included diabetic patients ≥30 years of age in each participating primary care practice, selected at random from an automated diabetes registry. Primary care practices were randomized within clinics to either a chronic care clinic (intervention) group or a usual care (control) group. The intervention group conducted periodic one-half day chronic care clinics for groups of ∼8 diabetic patients in their respective doctor’s practice. Chronic care clinics consisted of standardized assessments; visits with the primary care physician, nurse, and clinical pharmacist; and a group education/peer support meeting. We collected self-report questionnaires from patients and data from administrative systems. The questionnaires were mailed, and telephoned interviews were conducted for nonrespondents, at baseline and at 12 and 24 months; we queried the process of care received, the satisfaction with care, and the health status of each patient. Serum cholesterol and HbA1c levels and health care use and cost data was collected from HMO administrative systems. RESULTS—In an intention-to-treat analysis at 24 months, the intervention group had received significantly more recommended preventive procedures and helpful patient education. Of five primary health status indicators examined, two (SF-36 general health and bed disability days) were significantly better in the intervention group. Compared with control patients, intervention patients had slightly more primary care visits, but significantly fewer specialty and emergency room visits. Among intervention participants, we found consistently positive associations between the number of chronic care clinics attended and a number of outcomes, including patient satisfaction and HbA1c levels. CONCLUSIONS—Periodic primary care sessions organized to meet the complex needs of diabetic patients improved the process of diabetes care and were associated with better outcomes.
RECEPTORS ON IMMUNOCOMPETENT CELLS
Authors: Joseph M. Davie, William E. Paul
Journal: The Journal of Experimental Medicine (1971)

Nonimmunized guinea pigs possess rare lymphocytes which bind sufficient 2,4-dinitrophenyl-guinea pig albumin-125I (DNP-GPA) to their surface to be detected by short-term radioautography. The cells occur in the lymph nodes, spleen, peripheral blood, and bone marrow with a frequency of ∼40/100,000 lymphocytes, but are absent from the thymus. The receptors of these cells are largely specific for the haptenic group (ϵ-DNP-L-lysine) as shown by inhibition of DNP-GPA-125I binding with ϵ-DNP-L-lysine and with DNP bovine serum albumin (DNP-BSA). Furthermore, these cells specifically adsorb to agarose beads to which either DNP-GPA, DNP-BSA, or DNP-keyhole limpet hemocyanin (KLH) has been covalently linked. This hapten specific depletion of DNP-GPA-125I antigen-binding cells (ABC) correlates with a similar diminution in the capacity of adsorbed populations to transfer primary responsiveness to DNP-KLH to irradiated syngeneic recipients. Fluoresceinated anti-immunoglobulin binds to the surface of some guinea pig lymphocytes, and all DNP-GPA-125I ABC, as shown by a double-label technique. The great majority of DNP-GPA ABC and human γ-globulin ABC possess surface Ig molecules of the γ2 heavy chain class. Preincubation of cell suspensions with anti-γ2 antibody markedly diminishes the number of DNP-GPA-125I ABC which are detected, strongly suggesting that the receptors of these cells are immunoglobulin molecules, most of which possess γ2 heavy chains. The specificity characteristics of DNP-GPA-125I ABC are strikingly different from those of cells mediating a cellular immune response to DNP-GPA, indicating major differences in the specificity and nature of the receptors of these cell types.
Development and validation of the Mini Asthma Quality of Life Questionnaire
Authors: E.F. Juniper, G.H. Guyatt, F.m Cox, P.J. Ferrie, D.R. King
Journal: European Respiratory Journal (1999)

The 32-item Asthma Quality of Life Questionnaire (AQLQ) has shown good responsiveness, reliability and construct validity; properties that are essential for use in clinical trials, clinical practice and surveys. However, to meet the needs of large clinical trials and long-term monitoring, where efficiency may take precedent over precision of measurement, the 15-item self-administered MiniAQLQ has been developed. The MiniAQLQ was tested in a 9-week observational study of 40 adults with symptomatic asthma. Patients completed the MiniAQLQ, the AQLQ, the Short Form (SF)-36, the Asthma Control Questionnaire and spirometry at baseline, 1, 5 and 9 weeks. In patients whose asthma was stable between clinic visits, reliability was very acceptable for the MiniAQLQ (intraclass correlation coefficient (ICC)=0.83), but not quite as good as for the AQLQ (ICC=0.95). Similarly, responsiveness in the MiniAQLQ (p=0.0007) was good but not quite so good as for the AQLQ (p<0.0001). Construct validity (correlation with other indices of health status) was strong for both the MiniAQLQ and the AQLQ. Criterion validity showed that there was no bias between the instruments (p=0.61) and the correlation between them was high (r=0.90). The Mini Asthma Quality of Life Questionnaire has good measurement properties but they are not quite as strong as those of the original Asthma Quality of Life Questionnaire. The choice of questionnaire should depend on the task at hand.
Genome-Wide Association Studies for Taxane-Induced Peripheral Neuropathy in ECOG-5103 and ECOG-1199
Authors: Bryan P. Schneider, Lang Li, Milan Radovich, Fei Shen, Kathy D. Miller, David A. Flockhart, Guanglong Jiang, Gail Vance, Laura Gardner, Matteo Vatta, Shaochun Bai, Dongbing Lai, Daniel Koller, Fengmin Zhao, Anne O'Neill, Mary Lou Smith, Elda Railey, Carol White, Ann Partridge, Joseph Sparano, Nancy E. Davidson, Tatiana Foroud, George W. Sledge
Journal: Clinical Cancer Research (2015)

Taxane-induced peripheral neuropathy (TIPN) is an important survivorship issue for many cancer patients. Currently, there are no clinically implemented biomarkers to predict which patients might be at increased risk for TIPN. We present a comprehensive approach to identification of genetic variants to predict TIPN.
Diffuse plane xanthomatosis and acquired palmoplantar keratoderma in association with myeloma
Authors: C.H. SMITH, J.N.W.N. BARKER, R.J. HAY
Journal: British Journal of Dermatology (2006)

We report a patient with diffuse plane xanthomatosis, acquired palmoplantar keratoderma, and myeloma. Although diffuse plane xanthomatosis is a recognized manifestation of paraproteinaemia, keratoderma is not. However, successful treatment of the myeloma in our patient coincided with a dramatic improvement in the keratoderma, suggesting a genuine association between the two disorders.
Low Testosterone Levels in Elderly Men With Dysthymic Disorder
Authors: Stuart N. Seidman, Andre B. Araujo, Steven P. Roose, D.P. Devanand, Shan Xie, Thomas B. Cooper, John B. McKinlay
Journal: American Journal of Psychiatry (2002)

A decline in hypothalamic-pituitary-gonadal (HPG) axis function is often seen in elderly men, and dysthymic disorder is common. Symptoms of both HPG axis hypofunction and dysthymic disorder include dysphoria, fatigue, and low libido. The authors compared total testosterone levels in three groups of elderly men.Total testosterone levels were measured in subjects who met DSM-IV criteria for major depressive disorder (N=13) or dysthymic disorder (N=32) and a comparison group (N=175) who had participated in an epidemiological study of male aging and had scored below the median on the Center for Epidemiologic Studies Depression Scale, a well-validated, self-report depression symptom inventory.There were no differences among the three groups in measured demographic variables, including age and weight. Median testosterone levels varied for those with dysthymic disorder (295 ng/dl), major depressive disorder (425 ng/dl), and no depression (423 ng/dl). A test for differences in central tendency showed a statistically significant difference among the three groups. Post hoc pairwise comparisons revealed statistically significant differences between those with dysthymic disorder and those with major depressive disorder and no depression.Total testosterone levels were lower in elderly men with dysthymic disorder than in men with major depressive disorder and men without depressive symptoms. Dysthymic disorder in elderly men may be related to HPG axis hypofunction.
Are skilled players at greater risk of injury in female youth football?
Authors: Torbjørn Soligard, Hege Grindem, Roald Bahr, Thor Einar Andersen
Journal: British Journal of Sports Medicine (2010)

Background Knowledge of skill-related risk factors for injury in football is limited. Objective To investigate whether there is an association between football skills and risk of injury in football. Study Design Prospective cohort study of the incidence of injuries and a retrospective evaluation of the players' skill-level. Methods Exposure and injuries were registered prospectively in 82 of 125 football teams (1665 of 2540 female Norwegian amateur players aged 13–17 years) throughout one football season (March–October 2007). A standardised questionnaire designed to assess the football skills of each player was completed by the coaches after the season. Results Across the different skill attributes, the injury incidence in the high-skilled players varied from 4.4 to 4.9 injuries per 1000 player hours, compared to 2.8 to 4.0 injuries per 1000 player hours in the low-skilled players. Players skilled at ball receiving, passing and shooting, heading, tackling, decision-making when in ball possession or in defence and physically strong players were at significantly greater risk of sustaining any injury, an acute injury and a contact injury than their less skilled teammates (rate ratio: 1.50–3.19, all p&lt;0.05). Conclusions Players with high levels of football skill were at greater risk of sustaining injuries than their less skilled teammates.
Foot orthoses and gait: a systematic review and meta-analysis of literature pertaining to potential mechanisms
Authors: Kathryn Mills, Peter Blanch, Andrew R Chapman, Thomas G McPoil, Bill Vicenzino
Journal: British Journal of Sports Medicine (2009)

This article systematically reviews the available literature to improve our understanding of the physiological basis for orthoses under the kinematic, shock attenuation and neuromotor control paradigms. The propositions made under these three paradigms have not been systematically reviewed collectively, and as such, there is no single-point synthesis of this clinically relevant body of evidence and somewhat disparate findings. Our comprehensive search strategy yielded 22 papers. Under each paradigm, the role of orthoses with different design features including combinations of posting, moulding and density was analysed. Where possible, data have been pooled to provide an increased level of confidence in findings. The main findings in the kinematic paradigm were that posted non-moulded orthoses systematically reduced peak rearfoot eversion (2.12° (95% CI 0.72 to 3.53)) and tibial internal rotation (1.33° (0.12 to 2.53)) in non-injured cohorts. In the shock attenuation paradigm, it was found that non-posted moulded and posted moulded orthoses produced large reductions in loading rate and vertical impact force when compared with a control and to a posted non-moulded orthosis. The neuromotor control paradigm seems to be the least conclusive in its outcome. Based on our review, this paper concludes with rudimentary guidelines for the prescription of orthosis, that sports medicine practitioners may use in their clinical decision-making process. The need for further research focusing on the role of injury, particularly in neuromotor control modification and long-term adaptation to orthoses, was highlighted.
Chalk in the prime.
Authors: H Yeo, T Doyle, R Saynor, G H Smith
Journal: Thorax (1986)

After observations of cloudiness in the perfusion circuit at open intracardiac operations, laboratory experiments showed a precipitate in a Hartmann9s solution (compound sodium lactate solution, Ringer-lactate) and sodium bicarbonate based priming fluid used for cardiopulmonary bypass. The precipitate was found to consist of calcium carbonate crystals. The crystals were not dissolved by adding plasma proteins, nor were they sufficiently cleared from the extracorporeal circuit by a 40 microns filter in the arterial line. The crystals may embolise in microvascular beds and thus be a cause of postoperative morbidity. The practice of adding sodium bicarbonate to the pump prime may be unnecessary.
Hepatitis G virus infection in fulminant hepatic failure
Authors: J C Sáiz, M Sans, A Mas, E Olmedo, X Forns, F X López-Labrador, J C Restrepo, J Costa, J M Salmerón, M Guilera, S Ampurdanés, J M Sánchez-Tapias, M T Jiménez de Anta, J Rodés
Journal: Gut (1997)

Background —RNA sequences of the recently identified hepatitis GB virus C (HGBV-C), also named hepatitis G virus (HGV), have been detected in patients with idiopathic fulminant hepatic failure (FHF) but the role of this agent in the disease remains controversial. Aims —To investigate the presence and implications of HGV infection in a large series of Spanish patients with FHF. Patients —Sixty eight patients with FHF, including 19 with idiopathic disease, were studied. In 28 cases, studies were performed before and after liver transplantation. For comparison 200 volunteer blood donors and 22 patients transplanted for chronic liver disease were also studied. Methods —HGV RNA was measured in serum by reverse transcriptase polymerase chain reaction of the 5′ non-coding region. Results —Evidence of HGV infection was found in 3% (6/200) of blood donors and in 19% (13/68) of patients with FHF. HGV infection was more frequent in patients with hepatitis B (24%, 6/25) or hepatitis D (42%, 5/12), than in patients with idiopathic disease (11%, 2/19). Half of the patients with HGV infection used illicit intravenous drugs. Specific clinical features associated with HGV infection were not identified. A very high rate of infection with HGV was observed in patients who underwent liver transplantation, either for FHF (60%, 15/24) or chronic liver disease (45%, 9/20). Conclusions —In our geographical area, HGV infection is relatively frequent in FHF, but it does not seem to play a major role in idiopathic cases.