tbuckley/cabot-search huggingface dataset:
A CASE OF DELHI BOIL OR SORE (SYN: ORIENTAL SORE; ALEPPO BOIL).*
Authors: J. H. STOWERS, Aldo Castellani
Journal: British Journal of Dermatology (1920)

Journal Article A CASE OF DELHI BOIL OR SORE (SYN: ORIENTAL SORE; ALEPPO BOIL). Get access J. H. STOWERS, M.D., J. H. STOWERS, M.D. Search for other works by this author on: Oxford Academic Google Scholar Aldo Castellani, C.M.G., M.D. Aldo Castellani, C.M.G., M.D. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 32, Issue 8-9, 1 August 1920, Pages 263–265, https://doi.org/10.1111/j.1365-2133.1920.tb08989.x Published: 01 August 1920
The Psychedelic "Hip Scene": Return of the Death Instinct
Authors: HARRY R. BRICKMAN
Journal: American Journal of Psychiatry (1968)

The author discusses the relationship between the psychedelic experience and the nonviolent ethic of the growing "hippy" subculture within the frame of reference of Freud's death instinct theory, which held that externalization of the life and death instincts through aggressiveness prevents self-destruction of the individual. The psychedelic episode and the experience of ego dissolution ("dying") are seen as confirming the basic unity of life and death, thus eliminating the individual's need to externalize destructiveness.
The Paradox of the Dead Donor Rule: Increasing Death on the Waiting List
Authors: Robert M. Sade, Andrea Boan
Journal: The American Journal of Bioethics (2014)

James Bernat has been a leading advocate of donation after brain death (DBD) (Bernat 2014) and donation after circulatory death (DCD) (Bernat et al. 2010), as well as an eminent scholar regarding t...
Effective uptake of N-acetylglucosamine-conjugated liposomes by cardiomyocytes in vitro
Authors: Shin-ichi Aso, Hirohiko Ise, Masafumi Takahashi, Satoshi Kobayashi, Hajime Morimoto, Atsushi Izawa, Mitsuaki Goto, Uichi Ikeda
Journal: Journal of Controlled Release (2007)
Potential Bias of Instrumental Variable Analyses for Observational Comparative Effectiveness Research
Authors: Laura Faden Garabedian, Paula Chu, Sengwee Toh, Alan M. Zaslavsky, Stephen B. Soumerai
Journal: Annals of Internal Medicine (2014)

Instrumental variable analysis is an increasingly popular method in comparative effectiveness research (CER). In theory, the instrument controls for unobserved and observed patient characteristics that affect the outcome. However, the results of instrumental variable analyses in observational settings may be biased if the instrument and outcome are related through an unadjusted third variable: an "instrument-outcome confounder." The authors identified published CER studies that used instrumental variable analysis and searched the literature for potential confounders of the most common instrument-outcome pairs. Of the 187 studies identified, 114 used 1 or more of the 4 most common instrument categories: distance to facility, regional variation, facility variation, and physician variation. Of these, 65 used mortality as an outcome. Potential unadjusted instrument-outcome confounders were observed in all studies, including patient race, socioeconomic status, clinical risk factors, health status, and urban or rural residency; facility and procedure volume; and co-occurring treatments. Only 4 (6%) instrumental variable CER studies considered potential instrument-outcome confounders outside the study data. Many effect estimates may be biased by the failure to adjust for instrument-outcome confounding. The authors caution against overreliance on instrumental variable studies for CER.
813-3 Results of Valve Replacement with Mechanical versus Biological Prostheses in Patients on Chronic Renal Dialysis
Authors: John C. Lucke, Ravi N. Samy, B. Zane Atkins, Scott C. Silvestry, James M. Douglas, Steve J. Schwab, Walter G. Wolfe, Donald D. Glower
Journal: Journal of the American College of Cardiology (1995)
Specialist nurses in gastroenterology
Authors: C. Norton, M. A Kamm
Journal: Journal of the Royal Society of Medicine (2002)

A new species is emerging as a powerful force in the healthcare environment. This phenomenon is particularly evident in gastroenterology, although the same changes are occurring in most specialties. Every aspect of gastroenterological care is seeing a rapid development and expansion of specialist nurses. They are taking their place alongside medical specialists, or establishing themselves as the principal carer. What advantages, if any, do they offer over the gastro-enterologist? Are they a serious threat to consultant medical practice, or do they offer an important opportunity to improve patient care?
BH3-only protein Noxa regulates apoptosis in activated B cells and controls high-affinity antibody formation
Authors: Felix M. Wensveen, Ingrid A. M. Derks, Klaas P. J. M. van Gisbergen, Alex M. de Bruin, Joost C. M. Meijers, HaciAli Yigittop, Martijn A. Nolte, Eric Eldering, René A. W. van Lier
Journal: Blood (2011)
Atriogenic Mitral Valve Reflux: Diastolic Mitral Incompetence Following Isolated Atrial Systoles
Authors: JOHN C. P. WILLIAMS, T. PAUL B. O'DONOVAN, RUSSELL A. VANDENBERG, RALPH E. STURM, EARL H. WOOD
Journal: Circulation Research (1968)

Cardiac and aortic pressures were recorded after stellate ganglionectomy and vagotomy. Acute heart block was produced by injecting the atrioventricular node, and atrial and ventricular systoles were controlled electronically to occur independently or in any desired relationship. Angiocardiograms recorded on video tape after injections of 4 ml 69% Renovist into the left ventricle were analyzed with a videodensitometer able to detect small refluxes of contrast medium into the left atrium and correlate them with phases of the cardiac cycle. When ventricular driving was temporarily suspended but atrial driving continued, pressure records indicated mitral valve closure after each atrial systole, but reflux of contrast medium into the atrium occurred after each systole not followed by a normally sequenced ventricular systole. Driving with a 2: 1 atrioventricular stimulation resulted in reflux, with the alternate atrial contraction dissociated from ventricular systole. Thus, the mitral valve was not effectively closed by atrial systoles that were not followed by normally sequenced ventricular systoles.
Antibodies to Muscle and Thymus in Nonmyasthenic Patients with Thymoma
Authors: Dale E. McFarlin, Mahlon Barlow, Arthur J. L. Strauss
Journal: New England Journal of Medicine (1966)

DURING the past five years data relevant to the hypothesis that myasthenia gravis might be caused by or intimately related to immunologic aberrations have been brought forward.1 , 2 Strauss et al.3 demonstrated in vitro a skeletal muscle-binding, complement-fixing serum globulin in some patients with myasthenia gravis. This reactivity was subsequently shown to be associated with the serum immunoglobulins. Beutner and his associates4 confirmed these findings. More recently, van der Geld et al.5 reported that myasthenic serums containing antimuscle reactivity also react with thymic epithelial cell cytoplasmic elements. Reciprocal absorption studies with skeletal muscle and thymus tissues demonstrated common antigenic determinants in . . .
805 RIBAVIRIN NEITHER ENHANCES NOR ANTAGONIZES THE IN VIVO ACTIVITY OF VANIPREVIR IN THE CHIMPANZEE MODEL OF CHRONIC HCV INFECTION
Authors: S. Ludmerer, S. Carroll, C. Fandozzi, D. Graham, D. Hazuda, P. Wuelflng, D.B. Olsen
Journal: Journal of Hepatology (2011)
A Map of the Child: A Pediatrician's Tour of the Body
Authors: J. P. Brosco
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Review of Roberta M. Berry,<i>The Ethics of Genetic Engineering</i><sup>1</sup>
Authors: Erica K. Rangel
Journal: The American Journal of Bioethics (2010)

Since Justice Oliver Wendell Holmes's opinion in the 1927 U.S. Supreme Court case Buck v. Bell [274 U.S. 200 (1927)] authorized the involuntary sterilization of a young woman believed to be mentall...
Peripheral oedema in patients treated with isosorbide dinitrate.
Authors: J C Rodger
Journal: BMJ (1981)

Pulmonary hypertension after lung irradiation in infancyIrradiation of the lung may lead to several complications including pneumonitis, pulmonary fibrosis, pleural effusion, and pneumo- thorax.The development of pulmonary hypertension is less well known and was not recorded in either of two recent reviews of the complications of radiotherapy.' 2 We report a case here. Case reportA 14-year-old girl presented with an 18-month history of syncope and mild dyspnoea on effort.At the age of 7 months a neuroblastoma arising from 'Wohl MEB, Griscom NT, Traggis DG, Jaffe N. Effects of therapeutic irradiation delivered in early childhood upon subsequent lung function.
A Bridge Too Soon
Authors: Roberta Schaffner
Journal: JAMA (1992)

<h3>To the Editor.</h3> —I would like to correct a comment made in the February 19,1992, cover story. Dr Southgate<sup>1</sup>stated that the Brooklyn Bridge "was also the first suspension bridge in history to use steel wire for cables and steel for the structure suspended from the cables." The Roebling Bridge, across the Ohio River, connecting Cincinnati, Ohio, and Covington, Ky, was a prototype for the Brooklyn Bridge. It was built to the specifications of architect John Roebling and completed in 1865. Its steel wires and structures support me each day as I drive to work. I believe it to be the first suspension bridge of its type.<sup>2</sup>Ernest Lawson's painting<i>Brooklyn Bridge</i>captures a presence that was presaged by and still echoes in the Roebling Bridge. Dr Schaffner is correct in that the Brooklyn Bridge was not the first suspension bridge to use steel in its structure and
Effects of interleukin 2 on cardiac function in the isolated rat heart.
Authors: P A Sobotka, J McMannis, R I Fisher, D G Stein, J X Thomas
Journal: Journal of Clinical Investigation (1990)

Adoptive immunotherapy with IL 2 is associated with severe cardiovascular toxicities including peripheral and pulmonary edema, hypotension decreased systemic vascular resistance, increased heart rate, and an increased cardiac index. The purpose of this investigation was to determine whether IL 2 alone or in combination with lymphokine-activated killer cells (LAK) cells depress cardiac function using the isolated, perfused, working rat heart preparation. Male Sprague-Dawley rats (250-350 g) were anesthetized and the hearts were removed and placed on the perfusion apparatus. Hearts were perfused with oxygenated Krebs-Henseleit buffer (KHB), or oxygenated KHB containing IL 2 alone, IL 2-Media (cell culture media supplemented with 1,500 U IL 2/ml), LYMPH (cell culture media from cultured mononuclear cells from healthy volunteers), or LAK (cell culture media from cultured lymphocytes harvested from patients receiving IL 2/LAK in the presence of 1,500 U/ml IL 2). The cells were removed before perfusion (n = 9). Cardiac output and coronary flow were measured at 20-min intervals with preload constant (afterload varied or afterload constant (preload varied). The results indicate a significant depression in cardiac function in hearts treated with LAK. This depression was evident at 20 min and was more pronounced at 60 min. Washout of the KHB plus LAK reversed this depression. Thus, IL 2-stimulated/cultured human mononuclear cells produce a soluble factor that produces a reversible severe depression of cardiac function.
Implications of the Mild Coronary
Authors: Samuel Blinder
Journal: JAMA (1962)

<h3>To the Editor:—</h3> In the article, The Fate of the Mild Coronary (<i>JAMA</i><b>177</b>:579 [Aug. 26] 1961), Dr. Likoff poses the practical question: What does the term, mild coronary, imply? Unfortunately, when the attending physician makes such a diagnosis he is apt to minimize the seriousness of a myocardial infarction and permit too many liberties, including a very short period of bed rest. Clinically, we know that the severe chest pain in the average case will subside within 24 hours. I suppose that compared with those cases which on admission are either in shock, in failure, or have various types of arrhythmias that are severe at the onset, the other cases are relatively mild by comparison. The attending physician may indulge in wishful thinking and minimize the seriousness of the underlying pathology. When the patient suddenly becomes seriously ill, everybody seems surprised, including the family, who usually have been
Abnormal Coronary Flow Velocity Reserve After Coronary Intervention Is Associated With Cardiac Marker Elevation
Authors: Joerg Herrmann, Michael Haude, Amir Lerman, Rainer Schulz, Lothar Volbracht, Junbo Ge, Axel Schmermund, Heinrich Wieneke, Clemens von Birgelen, Holger Eggebrecht, Dietrich Baumgart, Gerd Heusch, Raimund Erbel
Journal: Circulation (2001)

Background —Residual reduction of relative coronary flow velocity reserve (rCVR) after successful coronary intervention has been related to microvascular impairment. However, the incidence of cardiac enzyme elevation as a surrogate marker of an underlying embolic myocardial injury in these cases has not been studied. Methods and Results —A series of 55 consecutive patients with successful coronary stenting, periprocedural intracoronary Doppler analysis, and determination of creatine kinase (CK; upper limit of normal [ULN] for women 70 IU/L, for men 80 IU/L) and cardiac troponin T (cTnT; bedside test, threshold 0.1 ng/mL) before and 6, 12, and 24 hours after intervention were studied. Postprocedural rCVR was the only intracoronary Doppler parameter that independently correlated with cTnT ( r =−0.498, P &lt;0.001) and CK outcome ( r =−0.406, P =0.002). Receiver operating characteristic analysis identified a postprocedural rCVR of 0.78 as the best discriminating value, with a sensitivity of 83.3% and 69.2% and a specificity of 79.1% and 76.2% for detection of cTnT and CK elevation, respectively. Stratified according to this cutoff value, the incidence of cTnT elevation was 52.6% in patients with (n=19) and 5.6% in patients without (n=36) a postprocedural rCVR &lt;0.78 ( P &lt;0.001), associated with a CK elevation &gt;1 times the ULN in 36.8% and 5.6% ( P =0.005) of patients, respectively. Conclusions —Cardiac marker elevation can frequently be found after coronary procedures that are associated with a persistent reduction of rCVR, indicating procedural embolization of atherothrombotic debris with microvascular impairment and myocardial injury as a potential underlying mechanism.
Work and talk – handedness and the stuff of life
Authors: Grant. R. Gillett
Journal: Behavioral and Brain Sciences (2003)

Wittgenstein shifted from a picture theory of meaning to a use-based theory of meaning in his philosophical work on language. The latter picture is deeply congenial to the view that language and the use of our hands in practical activity are closely related. Wittgenstein's theory therefore offers philosophical support for Corballis's suggestion that the development of spoken language is the basis of dominance phenomena.
Chronometric Infusor — An Apparatus for Protracted Ambulatory Infusion Therapy
Authors: Elton Watkins
Journal: New England Journal of Medicine (1963)

IT is desirable to prolong current forms of regional cancer infusion therapy by the use of a mechanism permitting, on an ambulatory, outpatient basis, parenteral administration of fluid containing antimetabolite drugs. A device has been developed and is currently in use on the cancer chemotherapy service at the Lahey Clinic to infuse small volumes of drug (3 to 5 ml. in twenty-four hours) accurately for periods of weeks or even months. The mechanism is also proving valuable in the animal laboratory since it permits the continuous parenteral infusion of drugs into unrestrained large animals (dogs).The miniaturized self-contained infusion assembly . . .
Inhibition of both neutral endopeptidase and endothelin converting enzyme lowers pulmonary pressures in congestive heart failure
Authors: Kenneth Dickstein, Hanka de Voogd, Milutin Miric, Roland Willenbrock, Veselin Mitrovic, Richard Pacher, Gabriele Bambasek, Paul Koopman
Journal: Journal of the American College of Cardiology (2003)
Low-Molecular-Weight Heparin for Treating Venous Thromboembolism
Authors: Maria M.W. Koopman
Journal: Annals of Internal Medicine (1999)

Letters5 January 1999Low-Molecular-Weight Heparin for Treating Venous ThromboembolismMichael Scott Mahoney, MD and Marc Kahn, MDMichael Scott Mahoney, MDSearch for more papers by this author and Marc Kahn, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-130-1-199901050-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In the editorial about the utility of low-molecular-weight heparin (LMWH) in the setting of venous thromboembolism, Koopman and Büller (1) make a strong argument in favor of the increased use of LMWH. However, we are not convinced that LMWH is safer than intravenous unfractionated heparin with regard to significant bleeding. The risk for bleeding is an important end point in the use of LMWH in the clinical setting.As evidence for their statement that LMWH has been shown (at least for deep venous thrombosis) to have “decreased risk of bleeding,” the authors cite their recent review with ...References1. Koopman MM, Büller HR. Low-molecular-weight heparins in the treatment of venous thromboembolism [Editorial]. Ann Intern Med. 1998;128:1037-9. LinkGoogle Scholar2. Turkstra F, Koopman MM, Büller HR. The treatment of deep venous thrombosis and pulmonary embolism. Thromb Haemost. 1997;78:489-96. CrossrefMedlineGoogle Scholar3. Low-molecular-weight heparin in the treatment of patients with venous thromboembolism. The Columbus Investigators. N Engl J Med. 1997; 337:657-62. Google Scholar4. Simonneau G, Sors H, Charbonnier B, Page Y, Laaban JP, Azarian R, et al. A comparison of low-molecular-weight heparin with unfractionated heparin for acute pulmonary embolism. The THESEE Study Group. Tinzaparine ou Heparine Standard: Evaluations dans l'Embolie Pulmonaire. N Engl J Med. 1997; 337:663-9. Google Scholar5. Lensing AW, Prins MH, Davidson BL, Hirsh J. Treatment of deep venous thrombosis with low-molecular-weight heparins. A meta-analysis. Arch Intern Med. 1995;155:601-7. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoLow-Molecular-Weight Heparins in the Treatment of Venous Thromboembolism Maria M.W. Koopman and Harry R. Buller Low-Molecular-Weight Heparin for Treating Venous Thromboembolism Maria M.W. Koopman and Harry R. Büller Metrics 5 January 1999Volume 130, Issue 1Page: 77KeywordsDeep vein thrombosisHemorrhageHeparinLow molecular weight heparinOdds ratioPulmonary diseasesPulmonary embolismSafetyStatistical dataVenous thromboembolism Issue Published: 5 January 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
General practices could be subject to "Ofsted style" ratings within two years
Authors: G. Iacobucci
Journal: BMJ (2013)

A new rating system to assess NHS services in England, akin to the school rating system used by Ofsted, the official body that inspects schools, could be rolled out to general practices in less than two years. However, it may need a longer development period before being extended to hospitals, experts have concluded.

Last year the health secretary, Jeremy Hunt, commissioned the health policy think tank the Nuffield Trust to conduct an independent review to assess the feasibility of proposals to reintroduce a simple ratings system for NHS services.1 The review identified a “clear gap” in the availability of information to patients that could properly inform them about the quality of care and improve the accountability of providers.

But it said that ministers should ensure that a range of measures were taken before they pressed ahead with plans, including assessing how and when services could adopt the new system and evaluating the costs and benefits …
More on Alternative Medicine
Authors: Ted J. Kaptchuk
Journal: Annals of Internal Medicine (2000)

Letters18 April 2000More on Alternative MedicineTed J. KaptchukTed J. KaptchukHarvard Medical School; Boston, MA 02215 (Kaptchuk)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-8-200004180-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Dr. Sergeant's discussion of the “inevitable truths” underlying medicine is eloquent. The term “faux medicine” is a creative addition to the groups of terms (such as “unproven” and “unscientific”) that view the common thread of alternative medicine as a bogus, primitive, and delusional conceptual model.Indeed, science and technology have bestowed much of humanity with enormous material benefits. But for most patients in the waiting room, their health care is not reducible to a scientific event. As Dr. Sergeant has implied, disease may be a physical fact, but existential, personal, and subjective considerations necessarily linger whenever health is ...References1. Eisenberg L. Disease and illness: distinctions between professional and popular ideas of sickness. Cult Med Psychiatry. 1977;1:9-23. CrossrefMedlineGoogle Scholar2. Hahn RA. “Treat the patient, not the lab.” Internal medicine and the concept of ‘person.’. Cult Med Psychiatry. 1982;6:219-36. CrossrefMedlineGoogle Scholar3. Hunter KM. Doctor's Stories. The Narrative Structure of Medical Knowledge. Princeton: Princeton Univ Pr; 1991. Google Scholar4. Cassel EJ. The nature of suffering and the goals of medicine. N Engl J Med. 1982;306:636-45. CrossrefGoogle Scholar5. Hauerwas S. Suffering Presence. Notre Dame, IN: Univ of Notre Dame Pr; 1986. Google Scholar Author, Article, and Disclosure InformationAuthors: Ted J. KaptchukAffiliations: Harvard Medical School; Boston, MA 02215 (Kaptchuk) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAlternative Views on Alternative Medicine Charles M. Bagley Jr. Alternative Views on Alternative Medicine Allen F. Shaughnessy Alternative Views on Alternative Medicine Arunabha Ganguly Alternative Views on Alternative Medicine Edzard Ernst Alternative Views on Alternative Medicine Ted J. Kaptchuk and David M. Eisenberg More on Alternative Medicine Michael J. Sergeant Metrics 18 April 2000Volume 132, Issue 8Page: 675KeywordsFearHealth care ePublished: 15 August 2000 Issue Published: 18 April 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...