tbuckley/cabot-search huggingface dataset:
Binding of beta-amyloid to the p75 neurotrophin receptor induces apoptosis. A possible mechanism for Alzheimer's disease.
Authors: M Yaar, S Zhai, P F Pilch, S M Doyle, P B Eisenhauer, R E Fine, B A Gilchrest
Journal: Journal of Clinical Investigation (1997)

Alzheimer's disease is a neurodegenerative disorder characterized by the extracellular deposition in the brain of aggregated beta-amyloid peptide, presumed to play a pathogenic role, and by preferential loss of neurons that express the 75-kD neurotrophin receptor (p75NTR). Using rat cortical neurons and NIH-3T3 cell line engineered to stably express p75NTR, we find that the beta-amyloid peptide specifically binds the p75NTR. Furthermore, 3T3 cells expressing p75NTR, but not wild-type control cells lacking the receptor, undergo apoptosis in the presence of aggregated beta-amyloid. Normal neural crest-derived melanocytes that express physiologic levels of p75NTR undergo apoptosis in the presence of aggregated beta-amyloid, but not in the presence of control peptide synthesized in reverse. These data imply that neuronal death in Alzheimer's disease is mediated, at least in part, by the interaction of beta-amyloid with p75NTR, and suggest new targets for therapeutic intervention.
CRITERION FOR ABNORMALITY IN REGIONAL CEREBRAL BLOOD FLOW STUDIES USING THE INHALATION XENON TECHNIQUE
Authors: A Waxman, C Wong, R Waxman, T Waxman, E Siegel, K Wynn, H Rose
Journal: Clinical Nuclear Medicine (1982)

Waxman, A; Wong, C; Waxman, R; Waxman, T; Siegel, E; Wynn, K; Rose, H Author Information
International Scientific Language.
Authors: W. S. Christopher
Journal: JAMA (1895)

Chicago, Dec. 21, 1895. <h3>To the Editor:</h3> —I have read with great interest your address on "The International Scientific Language" in theJournalof this date. The position taken with regard to French seems to be good although as a matter of fact, Spanish is an easier language even than French, and is now used by a greater number of people than any other language excepting English. Would it not be well, as a means of familiarizing the profession at large, in this country, with one of these languages, to have a page or two of the contents of theJournal, each week in the proposed International language? Very truly yours,
Saving Their Skins
Authors: Sowmya Varada, Dana Alessa
Journal: JAMA Dermatology (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Caecal tumour with hepatic metastases?
Authors: S Rajendra
Journal: Gut (2005)

In patients with gastro-oesophageal reflux disease (GORD), oesophageal and extraoesophageal symptoms are traditionally attributed to increased contact time between the mucosa and refluxates.However, the volume of reflux may be important by increasing the total amount of highly concentrated damaging substances, either by prolonging distal mucosal exposure or by expanding to more proximal areas.To date, it has not been possible to accurately measure the volume of gastro-oesophageal reflux.Determination of the volume of reflux will help to better understand the pathophysiology of GORD and to evaluate the efficacy of antireflux treatments. . . . . . . . .
Reducing Macrophage Proteoglycan Sulfation Increases Atherosclerosis and Obesity through Enhanced Type I Interferon Signaling
Authors: Philip L.S.M. Gordts, Erin M. Foley, Roger Lawrence, Risha Sinha, Carlos Lameda-Diaz, Liwen Deng, Ryan Nock, Christopher K. Glass, Ayca Erbilgin, Aldons J. Lusis, Joseph L. Witztum, Jeffrey D. Esko
Journal: Cell Metabolism (2014)
Review: Insufficient evidence exists about which drugs are associated with delirium; benzodiazepines may increase risk
Authors: Christopher R. Carpenter
Journal: Annals of Internal Medicine (2011)

ACP Journal Club21 June 2011Review: Insufficient evidence exists about which drugs are associated with delirium; benzodiazepines may increase riskChristopher R. Carpenter, MD, MScChristopher R. Carpenter, MD, MScWashington University, St. Louis, Missouri, USA (C.R.C.)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-154-12-201106210-02010 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationClegg A, Young JB. Which medications to avoid in people at risk of delirium: a systematic review. Age Ageing. 2011;40:23-9. https://pubmed.ncbi.nlm.nih.gov/21068014Clinical Impact RatingsGIM/FP/GP: Mental Health: Hospitalists: Geriatrics: References1 Laurila JV, Pitkala KH, Strandberg TE, Tilvis RS. Confusion assessment method in the diagnostics of delirium among aged hospital patients: would it serve better in screening than as a diagnostic instrument? Int J Geriatr Psychiatry. 2002;17:1112-9. [PMID: 12461759] Google Scholar2 Callahan CM, Hendrie HC, Tierney WM. Documentation and evaluation of cognitive impairment in elderly primary care patients. Ann Intern Med. 1995;122:422-9. [PMID: 7856990] Google Scholar3 Al-Aama T, Brymer C, Gutmanis I, et al. Melatonin decreases delirium in elderly patients: A randomized, placebo-controlled trial. Int J Geriatr Psychiatry. 2011;26:687-94. [PMID: 20845391] Google Scholar4 Larsen KA, Kelly SE, Stern TA, et al. Administration of olanzapine to prevent postoperative delirium in elderly joint-replacement patients: a randomized, controlled trial. Psychosomatics. 2010;51:409-18. [PMID: 20833940] Google Scholar5 Burkhart CS, Dell-Kuster S, Gamberini M, et al. Modifiable and nonmodifiable risk factors for postoperative delirium after cardiac surgery with cardiopulmonary bypass. J Cardiothorac Vasc Anesth. 2010;24:555-9. [PMID: 20227891] Google Scholar Author, Article, and Disclosure InformationAffiliations: Washington University, St. Louis, Missouri, USA (C.R.C.)This article was published at Annals.org on 7 June 2011. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBenzodiazepinics and the treatment of delirium: a literature reviewBehavioral, Psychiatric, and Cognitive Adverse Events in Older Persons Treated with GlucocorticoidsSevere Exacerbation of Psychosis After Sudden Withdrawal of Chlorpromazine in the Treatment of Methamphetamine-Associated Psychosis With Aripiprazole and ChlorpromazinePharmacologic Risk Factors for Post-Operative Delirium in Total Joint Arthroplasty Patients: A Case–Control Study 21 June 2011Volume 154, Issue 12Page: JC6-10KeywordsAntipsychoticsCohort studiesDeliriumDrugsMultivariate analysisOdds ratioOpioidsRisk ratioSystematic reviews ePublished: 21 June 2011 Issue Published: 21 June 2011 Copyright & PermissionsCopyright © 2011 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
The Potential Role of Hypoxia Inducible Factor 1α in Tumor Progression after Hypoxia and Chemotherapy in Hepatocellular Carcinoma
Authors: Zhen Fan Yang, Ronnie T. Poon, Jensen To, David W. Ho, Sheung Tat Fan
Journal: Cancer Research (2004)

Abstract This study investigates the possible molecular basis leading to failure in a treatment that is composed of hypoxia and chemotherapy in a rat orthotopic hepatoma model. Hypoxia was induced by hepatic artery ligation, whereas chemotherapeutic effect was achieved by intraportal injection of cisplatin. High-dose sodium salicylate was administered to achieve transcriptional blockade. Significant prolongation of animal survival was observed in the groups receiving hepatic artery ligation with cisplatin or sodium salicylate. Massive tumor cell necrosis and apoptosis were found in the ligation and all of the combined treatment groups. Up-regulation of hypoxia inducible factor 1α (HIF-1α) and vascular endothelial growth factor (VEGF) at both mRNA and protein levels were detected in the groups receiving ligation and ligation with cisplatin, whereas a decreased level of von Hippel-Lindau tumor suppressor protein was identified in the group receiving ligation with cisplatin. Sodium salicylate enhanced expression of von Hippel-Lindau tumor suppressor protein but down-regulated HIF-1α and VEGF levels after ligation with or without cisplatin. An increased number of activated hepatic stellate cells in the tumors were observed in the ligation and ligation with cisplatin groups, whereas they were greatly reduced by sodium salicylate. In vitro study revealed that under hypoxic condition, both cisplatin and sodium salicylate could remarkably augment P53 and caspase 3 levels. Cisplatin stimulated HIF-1α up-regulation, whereas sodium salicylate suppressed HIF-1α expression. In conclusion, tumor progression after hypoxia and chemotherapy might be related to up-regulation of HIF-1α and subsequent VEGF production, and transcriptional blockade by sodium salicylate could enhance the therapeutic efficacy of hypoxia and chemotherapy.
ABC of ENT. Pain in the ear.
Authors: H Ludman
Journal: BMJ (1980)

Inflammatory causes of pain in the ear are evident from inspecting the external ear and tympanic membrane.Injuries to the pinna with haematoma are obvious from the history.Perichondritis of the pinna is a rare complication of injury, usually surgical.Acute otitis externa may be a diffuse inflammation or a furuncle.A furuncle is a very tender swelling in the outer ear canal (there are no hair follicles in the bony meatus).Hearing is impaired only if the meatus is blocked by swelling or discharge, and fever occurs only when infection spreads in front of the ear, as cellulitis or erysipelas.Tender enlarged nodes may be palpable in front or behind the ear, but the tenderness is superficial, unlike the tenderness on deep pressure in acute otitis media.The pinna is tender on movement, which, again, does not occur in acute otitis media.Any discharge is thick and scanty, unlike the copious mucoid discharge of middle ear infection.
GENE EXPRESSION OF THE UBIQUITIN-PROTEASOME PATHWAY IS REFLECTED BY VENTILATORY EXPIRED GAS ANALYSIS INDICES AT PEAK EXERCISE IN HEART FAILURE
Authors: Karla M. Daniels, Stewart Lecker, Alexandra Zavin, Kelly Allsup, Jacob Joseph, Ross Arena, P. Christian Schulze, Peirang Cao, Mahalakshmi Santhanam, Daniel Forman
Journal: Journal of the American College of Cardiology (2012)
False Negative F-18 FDG PET/CT in Nonsmall Cell Lung Cancer Bone Metastases
Authors: Young-Sil An, Joon-Kee Yoon, Myoung-Hoon Lee, Chul-Woo Joh, Seok-Nam Yoon
Journal: Clinical Nuclear Medicine (2005)

Tc-99m MDP bone scintigraphy is frequently performed for suspected skeletal metastases in lung cancer. F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) has also proved useful for staging nonsmall cell lung cancer, and it offers superior spatial resolution and improved specificity for bone metastases. Although F-18 FDG-PET is superior to Tc-99m MDP bone scintigraphy for the detection of bone metastases, the sensitivity for sclerotic (osteoblastic) metastases by F-18 FDG PET/CT is lower than for lytic metastases. These bone metastases may not be glycolytically active and may be below the requisite tumor mass needed for FDG accumulation. We describe the case of false-negative F-18 FDG PET/CT findings in a 57-year-old woman who demonstrated sclerotic bone metastases from nonsmall cell lung cancer. F-18 fluoride PET demonstrates a similar uptake pattern as Tc-99m MDP.
Scientists, Officials Eye Tools Aimed at Combating Abuse of Painkillers
Authors: Bridget M. Kuehn
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The French Triple Centenary, I2 October 1989
Authors: W.A.D. Griffiihs, D.S. Wilkinson
Journal: British Journal of Dermatology (1990)

Journal Article The French Triple Centenary, I2 October 1989 Get access W.A.D. Griffiihs, W.A.D. Griffiihs St John's Hospital for Diseases of the Skin, Lisle Street, London WC2 H 7BT; U.K. Search for other works by this author on: Oxford Academic Google Scholar D.S. Wilkinson D.S. Wilkinson Whitecroft, Hervines Road, Amersham, Bucks HP6 5HT Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 122, Issue 6, 1 June 1990, Pages 845–846, https://doi.org/10.1111/j.1365-2133.1990.tb06282.x Published: 01 June 1990
Managing Sleep Complaints
Authors: Calvin Stafford
Journal: JAMA (1983)

This highly readable little book is designed to present a current inventory of clinical information pertinent to diagnosis and treatment of commonly encountered sleep problems that are presently the subject of considerable interest in both the professional and lay community. What was once the stepchild of clinical medicine is now becoming a recognized discipline.  This book presents a differential diagnosis of the various sleep-related complaints utilizing the new Association of Sleep Disorders Centers classification of sleep disorders. The classification is outlined and discussed in the opening chapter. The physiology of normal sleep is concisely presented with particular attention given to staging, age-related changes, and endocrine function. The material provides sufficient background for the discussion of sleep pathology in the subsequent chapters.  Insomnias are concisely presented. Medical factors, drugs, alcohol, and special considerations in the geriatric population are appropriately emphasized in the initial chapter. The insomnias related to major mental disorders
Retrospective diagnosis of congenital rubella.
Authors: J L Iuorio, C S Hosking, C Pyman
Journal: BMJ (1984)

One hundred and five children and adolescents with impaired hearing and 19 with impaired vision underwent in vitro tests (lymphocyte responsiveness and serum antibody to rubella) for retrospective diagnosis of intrauterine rubella. Tests yielded results consistent with intrauterine rubella in 30 (29%) of the patients with impaired hearing but only one (5%) of those with impaired vision. In addition, the reported incidence (10.8%) of rubella as a cause of deafness was obtained by questioning parents before the tests. Of 27 patients with impaired hearing of unknown aetiology but reported rubella contact during the pregnancy, seven (26%) had test results consistent with intrauterine rubella. The incidence of intrauterine rubella as a cause of deafness is probably underestimated when the diagnosis is based on the presence of several classic features.
Therapy of Choriocarcinoma and Related Trophoblastic Tumors with Folic Acid and Purine Antagonists
Authors: Min Chiu Li, Roy Hertz, Delbert M. Bergenstal
Journal: New England Journal of Medicine (1958)

TUMORS of trophoblastic origin may arise either in the uterus or in the gonads. They are characteristically highly malignant and spread rapidly both by direct extension and by metastasis to lungs and brain and less commonly to numerous other sites.We wish to report our experience with the treatment of 6 women and 5 men suffering from choriocarcinoma or related trophoblastic disease. We have previously reported our initial findings in 3 of these women and have also outlined our rationale for the use of an especially devised regimen of intensive, intermittent therapy with methotrexate (4-amino-N10 methyl pteroyglutamic acid).1 MethodsThe . . .
Interleukin-2 Therapy, Central Venous Catheters, and Nosocomial Sepsis
Authors: Eitan Shiloni
Journal: Annals of Internal Medicine (1990)

Letters and Corrections1 June 1990Interleukin-2 Therapy, Central Venous Catheters, and Nosocomial SepsisEitan Shiloni, MD, Eitan Gross, MD, Mervyn Shapiro, MDEitan Shiloni, MDSearch for more papers by this author, Eitan Gross, MDSearch for more papers by this author, Mervyn Shapiro, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-112-11-882_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:Snydman and colleagues (1) recently addressed the frequency of nosocomial infection in interleukin-2 (IL-2) therapy for advanced malignancies. The issue is specifically one of central-venous-catheter-related sepsis. Patients in this study had subclavian double-lumen catheters placed for intravenous access. Only 2 of the 20 episodes of bacteremia reported were clearly not catheter-related; the other 18 were regarded as definitely (n= 12) or probably (n= 2) catheter-related, or were suspected of being catheter-related (n= 4). Another recent study (2) was done at the National Cancer Institute to determine the efficacy of prophylactic antimicrobial drugs in preventing...References1. Snydman D, Sullivan B, Gill M, Gould J, Parkinson D, and Atkins M. Nosocomial sepsis associated with interleukin-2. Ann Intern Med. 1990;112:102-7. LinkGoogle Scholar2. Bock S, Lee R, and Fisher B. Prophylactic antibiotics decrease infection in patients receiving immunotherapy with interleukin-2. J Clin Oncol. 1990;8:161-9. CrossrefMedlineGoogle Scholar3. Klempner M, Noring R, Mier J, and Atkins M. Interleukin-2 (IL-2) treatment induces a profound neutrophil chemotactic defect [Abstract 1339]. Twenty-eighth Interscience Conference on Antimicrobial Agents and Chemotherapy. October 1988. Google Scholar4. Lee R, Lotze M, and Skibber J. Cardiorespiratory effects of immunotherapy with interleukin-2. J Clin Oncol. 1989;7:7-20. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Eitan Shiloni, MD; Eitan Gross, MD; Mervyn Shapiro, MDAffiliations: Hadassah University Hospital Jerusalem Israel PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPathogenesis of infections related to intravascular catheterization 1 June 1990Volume 112, Issue 11Page: 882-883KeywordsAntimicrobialsBacteremiaCancer preventionCathetersDrugsNosocomial infectionsSepsis ePublished: 1 December 2008 Issue Published: 1 June 1990 PDF downloadLoading ...
Infection after caesarean section
Authors: M. J Turner, M. Rasmussen
Journal: BMJ (1989)

antibiotics in these high risk situations has re- peatedly been shown to reduce the incidence of subsequent infection.In the labour ward attention to basic principles of asepsis and surgery can easily fall.This is understandable for a variety of reasons, but none the less it remains unacceptable.Lessons which were learnt by our predecessors from maternal deaths in the preantibiotic era are often forgotten by junior doctors, to whom antibiotics can become the panacea of all ills.By all means let us use prophylactic antibiotics for caesarean section in patients at high risk, but at the same time let us audit the figures for our own units and make sure that they are not being used to compensate for lack of proper attention to basic obstetric, aseptic, and surgical techniques.These result in savings that cost nothing.
A SUGGESTION FOR TREATMENT OF CERTAIN FORMS OF COCCYDYNIA
Authors: O. Beddard
Journal: BMJ (1912)

CASES of rutpture of the uiterus in wllicl tle fetus lhas been wlholly expelled into the abdominal cavity are amlong the imiost unfavourable for treatment that can be met with.Tlle patient only too often succumibs as the restult of sshock, haeinorrliage, or pelitonitis, in -spite of operative ,treatment.As I have been forttunate enouglh to lhave two stuch cases that recovered, operation being performed withini a short tinle of the occurrence of the rnpture, I thinlk it worth while to record them.CAS,E L l. A. 8., 35, was admitte(l inito the London HoSLpital with a diagnosis of ruLpture of the uteruts after applicationi of forcevI with the head above the h)rim.Onaccount of ihaemorrhage the forceps were takeni off and( examlination made.The painis ceased, the head was found to have recededl, thie initestine could be felt in the vagina, anid the fetuis was easily palpable und(ler