Itraconazole for Cryptococcal Infection in the Acquired Immunodeficiency Syndrome
Authors: Maria A. Viviani, Anna M. Tortorano, Paolo Carbonera Giani, Claudio Arici, Antonio Goglio, Paolo Crocchiolo, Mauro Almaviva
Journal: Annals of Internal Medicine (1987)

Letters and Corrections1 January 1987Itraconazole for Cryptococcal Infection in the Acquired Immunodeficiency SyndromeMARIA A. VIVIANI, M.D., ANNA M. TORTORANO, Ph.D., PAOLO CARBONERA GIANI, M.D., CLAUDIO ARICI, M.D., ANTONIO GOGLIO, M.D., PAOLO CROCCHIOLO, M.D., MAURO ALMAVIVA, M.D.MARIA A. VIVIANI, M.D.Search for more papers by this author, ANNA M. TORTORANO, Ph.D.Search for more papers by this author, PAOLO CARBONERA GIANI, M.D.Search for more papers by this author, CLAUDIO ARICI, M.D.Search for more papers by this author, ANTONIO GOGLIO, M.D.Search for more papers by this author, PAOLO CROCCHIOLO, M.D.Search for more papers by this author, MAURO ALMAVIVA, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-106-1-166_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Relapses of cryptococcal infection in patients with the acquired immunodeficiency syndrome (AIDS) have been reported frequently, and need of a long-term antifungal therapy is evident (1-3). The new triazole derivative, itraconazole (Janssen Pharmaceutica Beerse, Belgium), seems to be a promising drug for this purpose, as documented by our first results in the treatment of disseminated cryptococcosis in three patients with AIDS (4).All the patients were at first given the conventional therapy and had marked improvement, but treatment was discontinued after 20 to 45 days because of intolerance or toxicity in two patients and because of the...References1. MASUR H. New concepts in the therapy of infections in the acquired immunodeficiency syndrome, pp 802-804. In: FAUCI AS, moderator. The acquired immunodeficiency syndrome: an update. Ann Intern Med. 1985;102:800-13. LinkGoogle Scholar2. KOVACSKOVACSPOLIS JAM. Cryptococcosis in the acquired immunodeficiency syndrome. Ann Intern Med. 1985;103:533-8. LinkGoogle Scholar3. ZUGERLOUIEHOLZMANSIMBERKOFFRAHAL AERMJ. Cryptococcal disease in patients with the acquired immunodeficiency syndrome. Ann Intern Med. 1986;104:234-40. LinkGoogle Scholar4. VIVIANITORTORANOWOESTENBORGHSCAUWENBERGH MARG. Experience with itraconazole in deep mycoses in Northern Italy. Mykosen. 1987. (In press). MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Ospedale L. Sacco Milano Italy PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByTherapy of CryptococcosisCryptococcosisFungal infections in HIV-infected patientsApport des azolés dans le traitement des cryptococcosesCryptococcosis in the era of AIDS--100 years after the discovery of Cryptococcus neoformansItraconazole for the Treatment of Cryptococcosis in CatsDERMATOLOGIC MANIFESTATIONS OF INFECTIOUS DISEASES IN CARDIAC TRANSPLANT PATIENTSPulmonary CryptococcosisOpportunistic/nosocomial infections. Treatment and developmental therapeutics. II. cryptococcosisCryptococcal meningitis: the place of itraconazoleUptake of itraconazole by alveolar macrophagesCryptococcosis in an AIDS patient: Itraconazole efficacy after other therapeutic failuresItraconazole in Antifungal TherapyHigh-dose itraconazole in the treatment of severe mycosesThe Diagnosis and Management of AIDS Patients with Mycotic InfectionsImprovement of amphotericin B activity during experimental cryptococcosis by incorporation into specific immunoliposomesThe value of serum cryptococcal antigen in the diagnosis of cryptococcal infection in patients infected with the human immunodeficiency virusEuropean experience with itraconazole in systemic mycosesTherapeutic effect of the triazole Bay R 3783 in mouse models of coccidioidomycosis, blastomycosis, and histoplasmosisCryptococcal Meningitis in AIDS Patients A Pilot Study of Fluconazole Therapy in 52 PatientsOral Itraconazole Therapy of Cryptococcal Meningitis and Cryptococcosis in Patients with AIDSMycoses in AIDS Patients: An OverviewFungal Infections and AIDSFungal infections in the immunocompromised hostCurrent concepts in CryptococcosisItraconazole vs amphotericin B: in vitro comparative evaluation of the minimal inhibitory concentration (MIC) against clinically isolated yeastsCryptococcosisNeurological complications of infection with human immunodeficiency virus type 1Traitement d'attaque et d'entretien des meningo-encephalites cryptococciques au cours du SIDATherapeutic AgentsTreatment of Mycoses with ItraconazoleTreatment of Infections Associated with Human Immunodeficiency VirusCryptococcosis and AIDSVIRUS DIAGNOSTIC SCANNING ELECTRONMICROSCOPYFungal Infections in AIDSPharmacokinetic profile of orally administered itraconazole in human skinFungal infections in the acquired immunodeficiency syndromeProphylaxis of Aspergillosis in Immunocompromised PatientsAntifungal Agents Used for Deep-Seated Mycotic Infections 1 January 1987Volume 106, Issue 1Page: 166-166KeywordsAIDSAntifungalsCryptococcosisDrugsToxicity Issue Published: 1 January 1987 PDF DownloadLoading ...