Antral Injections of Botulinum A Toxin for the Treatment of Obesity
Authors: Jens D. Rollnik, Peter N. Meier, Michael P. Manns, Michael Gke
Journal: Annals of Internal Medicine (2003)

Letters18 February 2003Antral Injections of Botulinum A Toxin for the Treatment of ObesityJens D. Rollnik, MD, Peter N. Meier, MD, Michael P. Manns, MD, and Michael Gke, MDJens D. Rollnik, MDMedical School Hannover; 30623 Hannover, Germany (Rollnik, Meier, Manns, Gke), Peter N. Meier, MDMedical School Hannover; 30623 Hannover, Germany (Rollnik, Meier, Manns, Gke), Michael P. Manns, MDMedical School Hannover; 30623 Hannover, Germany (Rollnik, Meier, Manns, Gke), and Michael Gke, MDMedical School Hannover; 30623 Hannover, Germany (Rollnik, Meier, Manns, Gke)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-138-4-200302180-00026 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Background: In Germany, approximately 50% of the population are overweight and 20% are obese (1). Overweight and obesity increase the risk for metabolic complications, arterial hypertension, cardiovascular diseases, and cancer (1). Long-term reduction of excess weight may improve many of these health problems, but available treatmentsdiet, exercise, behavioral modification, and pharmacotherapyachieve only short-term, limited weight loss in most patients (2). Botulinum A toxin is a powerful, long-acting inhibitor of muscular contractions in both voluntary and smooth muscles. It has been used to treat neurologic (3, 4) and gastroenterologic disorders, including achalasia and, most recently, idiopathic gastroparesis (5, ...References1. Heseker H, Schmid A. [Epidemiology of obesity]. Ther Umsch. 2000;57:478-81. [PMID: 11026082] CrossrefMedlineGoogle Scholar2. Mun EC, Blackburn GL, Matthews JB. Current status of medical and surgical therapy for obesity. Gastroenterology. 2001;120:669-81. [PMID: 11179243] CrossrefMedlineGoogle Scholar3. Rollnik JD, Matzke M, Wohlfarth K, Dengler R, Bigalke H. Low-dose treatment of cervical dystonia, blepharospasm and facial hemispasm with albumin-diluted botulinum toxin type A under EMG guidance. An open label study. Eur Neurol. 2000;43:9-12. [PMID: 10601802] CrossrefMedlineGoogle Scholar4. Rollnik JD, Hierner R, Schubert M, Shen ZL, Johannes S, Trger M, . Botulinum toxin treatment of cocontractions after birth-related brachial plexus lesions. Neurology. 2000;55:112-4. [PMID: 10891916] CrossrefMedlineGoogle Scholar5. Kolbasnik J, Waterfall WE, Fachnie B, Chen Y, Tougas G. Long-term efficacy of Botulinum toxin in classical achalasia: a prospective study. Am J Gastroenterol. 1999;94:3434-9. [PMID: 10606299] CrossrefMedlineGoogle Scholar6. Miller LS, Szych GA, Kantor SB, Bromer MQ, Knight LC, Maurer AH, . Treatment of idiopathic gastroparesis with injection of botulinum toxin into the pyloric sphincter muscle. Am J Gastroenterol. 2002;97:1653-60. [PMID: 12135014] CrossrefMedlineGoogle Scholar7. Gui D, De Gaetano A, Spada PL, Viggiano A, Cassetta E, Albanese A. Botulinum toxin injected in the gastric wall reduces body weight and food intake in rats. Aliment Pharmacol Ther. 2000;14:829-34. [PMID: 10848669] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Medical School Hannover; 30623 Hannover, Germany (Rollnik, Meier, Manns, Gke) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByEndoscopic intragastric injection of botulinum toxin A in obese patients on bariatric surgery waiting lists: A randomised double-blind study (IntraTox study)Evaluation of endoscopic ultrasound-guided gastric botulinum toxin injections in the treatment of obesityIntragastric Botulinum Toxin A Injection Is an Effective Obesity Therapy for Patients with BMI > 40 kg/m2: a Systematic Review and Meta-analysisIs Intragastric Botulinum Toxin A Injection Effective in Obesity Treatment?The Positive Effects of a Calorie-Restricting High-Protein Diet Combined with Intragastric Botulinum Toxin Type A Application Among Morbidly Obese Patients: A Prospective, Observational Analysis of Eighty-Seven Grade 2 Obese PatientsGastrointestinal Uses of Botulinum ToxinEUS-Guided Intragastric Injection of Botulinum Toxin A in the Preoperative Treatment of Super-Obese Patients: a Randomized Clinical TrialThe Role of Endoscopic Intra-Gastric Botulinum Toxin-A for Obesity TreatmentBotulinum Toxin A for Controlling ObesityTreatment of Gastrointestinal Sphincters Spasms with Botulinum Toxin AGastric Antral Injections of Botulinum Toxin Delay Gastric Emptying but Do Not Reduce Body WeightTratamiento endoscópico de la obesidadBotulinum neurotoxin-A does not spread to distant muscles after intragastric injection: A double-blind single-fiber electromyography studyEffects of intramural administration of Botulinum Toxin A on gastric emptying and eating capacity in obese patientsEndoscopic Ultrasound-Guided Gastric Botulinum Toxin Injections in Obese Subjects: A Pilot StudyIntragastric injection of botulinum toxin for the treatment of obesity. Where are we?Intragastric Injection of Botulinum Toxin A for the Treatment of ObesityTreatment of morbid obesity by intraparietogastric administration of botulinum toxin: a randomized, double-blind, controlled studyBotulinum toxin for gastrointestinal disorders: Therapy and mechanismsEffect of botulinum toxin antral injection on gastric emptying and weight reduction in obese patients: a pilot studySafety and efficacy of therapy with botulinum toxin in obesity: a pilot studyBotulinum toxin type A injections: Adverse events reported to the US Food and Drug Administration in therapeutic and cosmetic casesEndoscopic injection of botulinum toxin in the gastric antrum for the treatment of obesity 18 February 2003Volume 138, Issue 4Page: 359-360KeywordsBody mass indexEatingGastroenterology and hepatologyGastroparesisHypertensionObesityOverweightSmooth musclesToxinsWeight loss ePublished: 18 February 2003 Issue Published: 18 February 2003 CopyrightCopyright © 2003 by American College of Physicians. 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