tbuckley/cabot-search huggingface dataset:
A rare cause of facial purpura: endoscopy
Authors: E. Adişen, N. Eroglu, M. Öztaş, M. Gürer
Journal: Endoscopy (2007)

A 43-year-old woman who underwent stomach endoscopy due to gastritis was referred to our department because of an eruption on her face, which had started during the procedure. Due to the frightening appearance of the lesions, the patient and the endoscopist failed to complete the procedure. On dermatologic examination, hundreds of pin-head-sized red macules on the face, oral mucosa, and neck were seen ([Figure 1]). Subconjunctival hemorrhage was also observed ([Figure 2]). There was no pruritus or constitutional symptoms. The patient was otherwise healthy. Hematologic causes were excluded, with normal complete blood count, prothrombin time, and partial thromboplastin time. The rash started to fade spontaneously within 24 hours, and had disappeared completely after 4 days without treatment.
Weight Loss in Amateur Wrestlers and Its Effect on Serum Testosterone Levels
Authors: Richard H. Strauss
Journal: JAMA (1985)

Levels of nine serum hormones, six skin-fold sites, and body weight were measured in 19 male amateur wrestlers during their competitive season and again two months after the season. Percent of body fat was estimated from skin-fold thicknesses. Body weight, body fat, testosterone level, and prolactin level were significantly lower during the wrestling season. Low serum testosterone levels were significantly correlated with low body fat, large loss of body fat, and large weight loss. These findings suggest that the dietary restriction practiced by some wrestlers may affect serum testosterone levels adversely. (<i>JAMA</i>1985;254:3337-3338)
The use of nanoscale topography to modulate the dynamics of adhesion formation in primary osteoblasts and ERK/MAPK signalling in STRO-1+ enriched skeletal stem cells
Authors: Manus J.P. Biggs, R. Geoff Richards, Nikolaj Gadegaard, Chris D.W. Wilkinson, Richard O.C. Oreffo, Matthew J. Dalby
Journal: Biomaterials (2009)
Medical Laboratory Technology and Clinical Pathology
Authors: Frances K. Widmann
Journal: JAMA (1970)

Like soap and cigarette manufacturers, publishing houses now have active competition among their own products. Saunders has two Big Books of clinical pathology running concurrently: the present volume, and theTodd-Sanford Clinical Diagnosis by Laboratory Methods, edited by Davidsohn and Henry. The two are altogether comparable in size and price. The titles provide an important clue to each book's goal. Davidsohn and Henry's title page emphasizesClinical Diagnosis, while Lynch et al stress the wordsMedical Laboratory Technology. By implication, the former is for the physician, the interpreter; the latter for the technologist, the doer. To a considerable degree this premise is true; more detailed and more numerous technical sections will be found in Lynch's book.  A more important reason for Lynch et al's success is the skill with which the authors combine theoretical material with practical details. Pressures of space require all multidiscipline laboratory books to adopt a compact,
Several Research Avenues May Improve Understanding of Multiple Sclerosis
Authors: Marsha F. Goldsmith
Journal: JAMA (1988)

RESTLESS LEGS and lagging libidos are two problems associated with multiple sclerosis for which potential solutions were offered at the 40th annual meeting of the American Academy of Neurology in Cincinnati. Also newly reported is the value of magnetic resonance imaging in studying the progress of this disease. Frederick M. Vincent, MD, clinical associate professor of medicine and psychiatry at Michigan State University College of Human Medicine, East Lansing, presented preliminary data from a small group of patients that, he said, "appear quite promising" for helping to combat the chronic fatigue known to more than 90% of persons with multiple sclerosis. Vincent, who recently served as chief of neurology in the university's Department of Medicine, was treating a patient who did not respond well to amantadine hydrochloride (Symmetrel), the standard drug therapy for multiple sclerosis—associated fatigue. The patient, as it happened, was among the estimated 5% or so of the
Violence and the Brain
Authors: Frederick E. Jackson
Journal: JAMA (1971)

Two members of the Harvard Medical School staff have teamed together to write a most provocative and interesting book. This is a short monograph compiling their recent work on the organ of behavior, the brain. The central theme in the book is that the limbic system, particularly the amygdala, uncus, hippocampus and cingulum form the primitive "fight or flight" center of the brain. Modifying the species' tendency for basic destructive tendencies is the control exerted by the neocortex. When this stimulus-control system becomes unbalanced, violent acts of rage and destruction are likely to ensue. Supporting this thesis are the authors' facts that 50% of prisoners in a current study had abnormal electroencephalograms, that amygdaloid lesions that are stimulatory have been responsible for violent acts in many patients, that even the ferocious wolverine can be calmed by experimental lesions made in the amygdala, and that sensational crimes of violence have often
THE YELLOW FEVER EPIDEMIC OF 1903 AT LAREDO, TEXAS.
Authors: G. M. GUITERAS
Journal: JAMA (1904)

In accordance with orders from the Surgeon General, I arrived in Laredo, Texas, September 25, in company with Dr. George R. Tabor, state health officer of Texas, whom I met at San Antonio. Dr. Tabor and I discussed the probable situation at Laredo and the steps to be taken to combat the outbreak of yellow fever at that point. Among other things we touched on the necessity of a detention camp. In the name of the Government I offered to establish and run such a camp. The offer, however, was courteously refused by Dr. Tabor for the reason that he believed it would appear derogatory to the dignity of the State of Texas so to do. On our arrival at Laredo we proceeded at once to view the two fatal cases of supposed yellow fever that had occurred during the day, Cortina and Gilkerson. In both the history was that of
THE SAFETY OF ETHYL CHLORIDE, AND THE POSITION OF THE PATIENT DURING GENERAL ANAESTHESIA
Authors: R. W. Hornabrook
Journal: BMJ (1929)

the case which had had no morphine prioir to the operatioii had hail the heroin administered much sooller tlhain in tlhe first case.Since this episode, whiclh nearly ended in.a catastrophe, my practice has been (1) to be quite sure that the lpatient is fully round from the anaesthetic before any hypodermic injection is administered, and (2) to giv- only 1/12 grain of heroin, and to repeat it if necessary.My preference for heroin over moirphine is still very stronlg; buit the above two cases show that its effect o'n the resp)itatory centre may be exceedingly dangerous unless it is given in small doses.It is to draw attention to this fact that I have tlhought it advisable to publish these two cases.
The feed-forward loop between YB-1 and MYC is essential for multiple myeloma cell survival
Authors: K S Bommert, M Effenberger, E Leich, M Küspert, D Murphy, C Langer, R Moll, S Janz, A Mottok, S Weissbach, A Rosenwald, R Bargou, K Bommert
Journal: Leukemia (2012)
Time from diagnosis to intensive chemotherapy initiation does not adversely impact the outcome of patients with acute myeloid leukemia
Authors: Sarah Bertoli, Emilie Bérard, Françoise Huguet, Anne Huynh, Suzanne Tavitian, François Vergez, Sophie Dobbelstein, Nicole Dastugue, Véronique Mansat-De Mas, Eric Delabesse, Eliane Duchayne, Cécile Demur, Audrey Sarry, Valérie Lauwers-Cances, Guy Laurent, Michel Attal, Christian Récher
Journal: Blood (2013)
BAFF enhances chemotaxis of primary human B cells: a particular synergy between BAFF and CXCL13 on memory B cells
Authors: Gamal Badr, Gwenoline Borhis, Eric A. Lefevre, Nada Chaoul, Frederique Deshayes, Valérie Dessirier, Genevieve Lapree, Andreas Tsapis, Yolande Richard
Journal: Blood (2008)
Trends in Permanent Pacemaker Implantation in the United States From 1993 to 2009
Authors: Arnold J. Greenspon, Jasmine D. Patel, Edmund Lau, Jorge A. Ochoa, Daniel R. Frisch, Reginald T. Ho, Behzad B. Pavri, Steven M. Kurtz
Journal: Journal of the American College of Cardiology (2012)
Prolonged Therapy of Advanced Chronic Hepatitis C with Low-Dose Peginterferon
Authors: Adrian M. Di Bisceglie, Mitchell L. Shiffman, Gregory T. Everson, Karen L. Lindsay, James E. Everhart, Elizabeth C. Wright, William M. Lee, Anna S. Lok, Herbert L. Bonkovsky, Timothy R. Morgan, Marc G. Ghany, Chihiro Morishima, Kristin K. Snow, Jules L. Dienstag
Journal: New England Journal of Medicine (2008)

In patients with chronic hepatitis C who do not have a response to antiviral treatment, the disease may progress to cirrhosis, liver failure, hepatocellular carcinoma, and death. Whether long-term antiviral therapy can prevent progressive liver disease in such patients remains uncertain.We conducted a randomized, controlled trial of peginterferon alfa-2a at a dosage of 90 microg per week for 3.5 years, as compared with no treatment, in 1050 patients with chronic hepatitis C and advanced fibrosis who had not had a response to previous therapy with peginterferon and ribavirin. The patients, who were stratified according to stage of fibrosis (622 with noncirrhotic fibrosis and 428 with cirrhosis), were seen at 3-month intervals and underwent liver biopsy at 1.5 and 3.5 years after randomization. The primary end point was progression of liver disease, as indicated by death, hepatocellular carcinoma, hepatic decompensation, or, for those with bridging fibrosis at baseline, an increase in the Ishak fibrosis score of 2 or more points.We randomly assigned the patients to receive peginterferon (517 patients) or no therapy (533 patients) for 3.5 years. The level of serum aminotransferases, the level of serum hepatitis C virus RNA, and histologic necroinflammatory scores all decreased significantly (P<0.001) with treatment, but there was no significant difference between the groups in the rate of any primary outcome (34.1% in the treatment group and 33.8% in the control group; hazard ratio, 1.01; 95% confidence interval, 0.81 to 1.27; P=0.90). The percentage of patients with at least one serious adverse event was 38.6% in the treatment group and 31.8% in the control group (P=0.07).Long-term therapy with peginterferon did not reduce the rate of disease progression in patients with chronic hepatitis C and advanced fibrosis, with or without cirrhosis, who had not had a response to initial treatment with peginterferon and ribavirin. (ClinicalTrials.gov number, NCT00006164.)
Intracranial Aneurysm With Panhypopituitarism
Authors: Joel Curtis
Journal: JAMA (1968)

Aneurysm of the left carotid artery with resultant panhypopituitarism was seen in a patient with associated aneurysm of thoracic and abdominal aorta. Hypopituitarism is thought to have resulted from he presence of the aneurysm with atrophy of the pituitary gland.
ESSENTIAL VASCULAR HYPERTENSION
Authors: JOSEPH H. BARACH
Journal: JAMA (1922)

Vascular hypertension, according to our present day conception, is found in one group of individuals who have demonstrable pathologic lesions. These lesions when discovered are usually of the atherosclerotic type. The greatest damage caused by these lesions occurs in the brain, in the heart and in the kidneys. Vascular hypertension occurs in another group of individuals in whom all the diagnostic methods of today fail to reveal which organ is at fault. This type of case has been designated essential vascular hypertension. Since the etiology of hypertension is an unsolved problem, it is our duty to continue its discussion. This paper deals with some etiologic factors in the life history of these patients, and above all is an attempt to show there is a continuity in this disease, from the early to the later life of the individual. Essential vascular hypertension is not a spontaneous occurrence. During the last three
Enhancing Prescription Drug Innovation and Adoption
Authors: G. Caleb Alexander, Alec B. O'Connor, Randall S. Stafford
Journal: Annals of Internal Medicine (2011)

The adoption and use of a new drug would ideally be guided by its innovation and cost-effectiveness. However, information about the relative efficacy and safety of a drug is typically incomplete even well after market entry, and various other forces create a marketplace in which most new drugs are little better than their older counterparts. Five proposed mechanisms are considered for promoting innovation and reducing the use of therapies ultimately found to offer poor value or have unacceptable risks. These changes range from increasing the evidence required for U.S. Food and Drug Administration approval to modifying the structure of drug reimbursement. Despite the challenges of policy implementation, the United States has a long history of successfully improving the societal value and safe use of prescription medicines.
Rapid-Test Sensitivity for Novel Swine-Origin Influenza A (H1N1) Virus in Humans
Authors: Dennis J. Faix, Sterling S. Sherman, Steven H. Waterman
Journal: New England Journal of Medicine (2009)

To the Editor: The Naval Health Research Center serves as the Navy hub for the Department of Defense's Global Emerging Infections Surveillance and Response System (GEIS), in which it monitors influenza-like illness among recruit trainees of all military services, military dependents, and crew members of large Navy ships (population, >1000). The center works in collaboration with the Border Infectious Disease Surveillance Project of the Centers for Disease Control and Prevention (CDC), which monitors populations located on the border between California and Mexico. The first two human cases of novel swine-origin influenza A (H1N1) virus (S-OIV), known as swine flu, in . . .
Abstract LB-15: Oncogenic BRAF mutation, IGFBP7 silencing and evasion of senescence in colorectal tumorigenesis
Authors: Kevin J. Spring, Mariska Miranda, Winnie Fernando, Kazutomo Togashi, Graeme P. Young, Barbara A. Leggett
Journal: Cancer Research (2010)

Abstract Serrated polyps are now recognized as the precursor lesion from which sporadic BRAF (V600E) mutant/CIMP-H colorectal cancers (CRC) develop, but it appears likely BRAF mutation alone is not enough to drive progression to carcinoma. CIMP is generally localized to the proximal colon and may cause the epigenetic silencing of key genes such as IGFBP7 that may act in concert with BRAF mutation to promote neoplasia. We are conducting a detailed molecular analysis of the mechanism of serrated neoplasia involving IGFBP7 and evasion of oncogene-induced senescence (OIS). Normally senescence functions as a defense mechanism against tumorigenesis in precursor lesions. We have analysed 44 CRCs and 217 colorectal polyps including 45 advanced serrated polyps (sessile serrated adenomas, serrated adenomas and mixed polyps) and 109 simple serrated polyps (goblet cell rich hyperplastic polyps and microvesicular hyperplastic polyps) for BRAF, K-ras and CIMP relative to clinicopathologic variables. In addition a MethyLight assay was developed to determine IGFBP7 methylation patterns in serrated polyps and cancers. For serrated polyps, both BRAF mutation (75.5%) and CIMP (46.6%) was most frequent in advanced serrated polyps (ASPs). Overall the frequency of CIMP was significantly associated with proximal location (P&amp;lt;0.0001) and larger size (P&amp;lt;0.005). When serrated polyps were analyzed separately, histological type and location showed strong associations, with CIMP frequency differing significantly in proximal vs distal BRAF mutant ASPs and GC/MV-HPs. We find that BRAF mutation is highly associated with both SSAs and MV-HPs throughout the colorectum, but only in proximal SSAs is CIMP highly associated with BRAF mutation (70.8%). For CRCs we found IGFBP7 methylation frequently associated with CIMP and BRAF mutation (87%). For serrated polyps, IGFBP7 methylation was significantly associated with ASPs (P&amp;lt;0.0002), larger size (P&amp;lt;0.0002) and proximal location (P&amp;lt;0.0004). In advanced serrated polyps, which harbour both BRAF mutation and exhibit CIMP, methylation of IGFBP7 was observed 65% of cases. We are currently determining p53 expression levels, Ki67 and the senescence markers p19ARF and Dec1 in different serrated polyp types. This investigation will provide evidence for the involvement of IGFBP7 loss, by DNA hypermethylation, in the evasion of senescence and resulting in the progression of BRAF mutant/CIMP-H carcinoma of the colon. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr LB-15.
Personnel Selection in the Medical Sciences
Authors: Michael B. Shimkin
Journal: JAMA (1964)

<h3>To the Editor:—</h3> The process of selection and appointment of individuals to important professional positions in the United States is difficult to describe and even more difficult to defend. The usual mechanism is the designation by a dean and advisors of a "search" committee, which arrive at a slate of names on the basis of discussions among themselves and contacts with their friends or persons that presumably know the personnel market in the field. Into this pot are often thrown names of individuals, backed by influential administrative or faculty members, who are known to be interested through informal conversations or, perhaps, simple osmosis. It is seldom that the availability of the post becomes generally known. This occurs often as an open secret after the offer has been turned down by some candidates, contacted after the ceremony of obtaining permission from the employer in order to avoid the criticism of personnel
Evaluation of Skin Vasomotor Reflexes in Response to Deep Inspiration in Diabetic Patients by Laser Doppler Flowmetry: A new approach to the diagnosis of diabetic peripheral autonomic neuropathy
Authors: Yoshimasa Aso, Toshihiko Inukai, Yoshihiro Takemura
Journal: Diabetes Care (1997)

OBJECTIVE To evaluate the peripheral sympathetic function in feet of NIDDM patients by means of laser Doppler flowmetry. RESEARCH DESIGN AND METHODS After deep inspiration, we measured the vasoconstrictor response in the feet of 51 patients with NIDDM, as compared with those of 20 healthy control subjects, using laser Doppler flowmetry. Subjects whose skin temperature was &amp;lt; 32°C were excluded from our study because a skin temperature of ∼ 34°C is the optimal temperature for the evaluation of skin vasomotor reflexes in response to a deep inspiration by laser Doppler flowmetry. RESULTS The vasoconstrictor response to deep inspiration in the big toe was significantly decreased in NIDDM patients compared with healthy subjects (26.8 ± 2.0 vs. 48.3 ± 18.5%, P &amp;lt; 0.0001). In NIDDM patients, the vasoconstrictor response was positively correlated with the duration of diabetes, the median motor and sensory nerve conduction velocities, the coefficient of variation of the R-R interval at rest, and the postural fall in systolic blood pressure. The vasoconstriction was inversely correlated with the vibratory perception threshold. CONCLUSIONS Vasomotor reflexes in the lower limbs were markedly impaired in NIDDM patients. The measurement of vasoconstrictor responses to deep inspiration by using laser Doppler flowmetry is a novel and useful method for detecting peripheral sympathetic failure in diabetic patients.
Esophageal Stenosis Caused by Peptic Esophagitis or Ulceration
Authors: Edward B. Benedict, J. E. O'N. Gillespie
Journal: New England Journal of Medicine (1954)

SINCE operations on the esophagus are now commonplace and since peptic stenosis of the esophagus is of great current interest to the internist, radiologist, endoscopist and thoracic surgeon, it seems appropriate to review this controversial subject and bring it up to date.Etiology Incidence Vinson1 found 40 cases of unknown origin among 243 patients with benign stenosis of the esophagus. Benedict and Sweet2 reported 60 cases of what is now termed peptic stenosis among 1000 patients undergoing esophagoscopy. Of 1340 patients examined in this clinic, 119 (8.7 per cent) had peptic stenosis (100 of these being the basis of a . . .
Mechanisms of hypercapneic pulmonary hypertension
Authors: A. SUSMANO, M. PASSOVOY, R. A. CARLETON
Journal: Cardiovascular Research (1977)

Journal Article Mechanisms of hypercapneic pulmonary hypertension Get access A. SUSMANO, A. SUSMANO 2 From the Department of Medicine, Section of Cardiology, Rush-Presbyterian-St Luke's Medical Center, and Rush Medical College, Chicago, Illinois 2Correspondence to: Dr Armando Susmano, Director, Division of Cardiology, Mount Sinai Hospital Medical Center, California Avenue at 15th Street, Chicago, Illinois 60608, USA. Search for other works by this author on: Oxford Academic PubMed Google Scholar M. PASSOVOY, M. PASSOVOY From the Department of Medicine, Section of Cardiology, Rush-Presbyterian-St Luke's Medical Center, and Rush Medical College, Chicago, Illinois Search for other works by this author on: Oxford Academic PubMed Google Scholar R. A. CARLETON R. A. CARLETON From the Department of Medicine, Section of Cardiology, Rush-Presbyterian-St Luke's Medical Center, and Rush Medical College, Chicago, Illinois Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 11, Issue 5, September 1977, Pages 440–445, https://doi.org/10.1093/cvr/11.5.440 Published: 01 September 1977
Cotton dust produces an increase in intraepithelial mucosubstances in rat airways.
Authors: T Gordon, J R Harkema
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

Occupational exposure to endotoxin-contaminated organic dusts is associated with a variety of adverse pulmonary effects, including chronic bronchitis and sputum production. We have previously demonstrated in F344 rats that inhaled endotoxin rapidly induces an increase in the volume of stored intraepithelial mucosubstances (Vs) in the respiratory tract. The present study examined whether endotoxin-contaminated cotton dust can produce a similar increase in Vs in this animal model. Rats were exposed to air or 1.5 to 15.0 mg/m3 cotton dust for 2 h/d for 3 d. Twenty-four hours after the final exposure, the nasal cavity and lungs were fixed in formalin and the presence of Alcian blue/periodic acid-Schiff-staining mucosubstances determined by morphometry. Exposure to cotton dust produced concentration-dependent changes in Vs in the nasal septum and intrapulmonary airways. Statistically significant increases in Vs were observed in the epithelial lining of the nasal septum of animals exposed to 5.3 and 14.5 mg/m3 cotton dust (equivalent to 2.8 and 8.9 micrograms/m3 endotoxin). Vs in the intrapulmonary airways was also significantly increased at these concentrations. No significant changes were observed in the nasal septum or intrapulmonary airways after exposure to 1.8 mg/m3 cotton dust. These results are consistent with the hypothesis that endotoxin may contribute to the increase in human cases of chronic bronchitis reported in occupational settings in which endotoxin-contaminated dusts are encountered.