tbuckley/cabot-search huggingface dataset:
Faecal Fistula of Two Years and Two Months' Standing Following Herniotomy for Strangulated Hernia: Operation: Cure
Authors: A. Bowlby
Journal: BMJ (1895)

December 31st she was allowed to have a little barley water.She vomited, at 11 P.m. on that day, a little greenish fluid; and on January 1st was ordered to have milk and soda, barley water, and koumiss.The general condition good.The abdo- men was a little distended; flatus was passing freely.She was given a turpentine enema on this night.No fteces passed, but some flatus and the remains of the nutrient enemata.After this the patientwent on steadily towards recovery.There was no further vomiting.On January 9th she had a sponge bun.On January 19th some fish, and on January 21st some fowl.On January 25th she got up, and on February 9th went for a drive.From time to time I have seen Mrs. R. since she passed from my direct observation.In the course of a few months she resumed her ordinary duties, and gradually she found herself able to enjoy unconscious digestion.At the present time she is in vely good health, and shows -no sign of having suffered from any serious disease.ExYAMINATION OF TuMOuR.Length 12-inch; circumference 6 inches.The pyloric open- ing barely admitted the tip of the little finger; the stomach
Cardiac Complications in Amitriptyline Poisoning
Authors: Jonathan Tobis
Journal: JAMA (1976)

THE USE of tricyclic antidepressant medications is increasing as a form of self-poisoning. There have been a number of reports of the anticholinergic effects of amitriptyline hydrochloride and imipramine hydrochloride.<sup>1</sup>Although many cases of cardiotoxicity have been reported,<sup>2</sup>there is little information concerning the treatment of the serious cardiac complications. Physostigmine salicylate has been used successfully to treat the central effects of tricyclic antidepressants, such as agitation, seizures, and coma, as well as their peripheral effects, such as tachycardia.<sup>1</sup>We have used this drug in treating a young woman who had a cardiac arrest subsequent to an amitriptyline overdose. To our knowledge, this is the first reported case of amitriptyline poisoning in which malignant arrhythmias and conduction defects were successfully treated with physostigmine. <h3>Report of a Case</h3> A 22-year-old woman ingested an estimated 750 to 1,000 mg of amitriptyline hydrochloride (Elavil) on March 25, 1975. She was
Antibiotic-Resistant Enterococci and Fecal Indicators in Surface Water and Groundwater Impacted by a Concentrated Swine Feeding Operation
Authors: Amy R. Sapkota, Frank C. Curriero, Kristen E. Gibson, Kellogg J. Schwab
Journal: Environmental Health Perspectives (2007)

The nontherapeutic use of antibiotics in swine feed can select for antibiotic resistance in swine enteric bacteria. Leaking swine waste storage pits and the land-application of swine manure can result in the dispersion of resistant bacteria to water sources. However, there are few data comparing levels of resistant bacteria in swine manure-impacted water sources versus unaffected sources.The goal of this study was to analyze surface water and groundwater situated up and down gradient from a swine facility for antibiotic-resistant enterococci and other fecal indicators.Surface water and groundwater samples (n = 28) were collected up and down gradient from a swine facility from 2002 to 2004. Fecal indicators were isolated by membrane filtration, and enterococci (n = 200) were tested for susceptibility to erythromycin, tetracycline, clindamycin, virginiamycin, and vancomycin.Median concentrations of enterococci, fecal coliforms, and Escherichia coli were 4- to 33-fold higher in down-gradient versus up-gradient surface water and groundwater. We observed higher minimal inhibitory concentrations for four antibiotics in enterococci isolated from down-gradient versus up-gradient surface water and groundwater. Elevated percentages of erythromycin- (p = 0.02) and tetracycline-resistant (p = 0.06) enterococci were detected in down-gradient surface waters, and higher percentages of tetracycline- (p = 0.07) and clindamycin-resistant (p < 0.001) enterococci were detected in down-gradient groundwater.We detected elevated levels of fecal indicators and antibiotic-resistant enterococci in water sources situated down gradient from a swine facility compared with up-gradient sources. These findings provide additional evidence that water contaminated with swine manure could contribute to the spread of antibiotic resistance.
Osteogenic Sarcoma: Advances in Treatment
Authors: N. Jaffe, E. Frei
Journal: CA A Cancer Journal for Clinicians (1976)

Prior to 1972, no progress had been achieved in the treatment of osteogenic sarcoma.A maximum of 20 percent of patientswere cured by amputation.There was no effective systemic treat ment.This article presents some of the major advances in the management of osteogenic sarcoma during the past four years.Osteogenic sarcoma may be divided into three stages: primary tumor, micro metastases and overt metastatic disease.(Table I.) Patients in the primary tumor stage have, in the past, generally been treated by amputation.In the absence of systemic treatment, 80-90 percent of pa tients in the micrometastatic stage, that is those with subclinical disease, re lapsed three to 12 months after control of the primary tumor.Patients with overt metastatic disease, the third stage, usu ally develop progressive respiratory fail ure and die at a median of six months following the appearance of overt pul
Patient Education Program Proposed
Authors: Stuart L. Nightingale
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pedophilia and Exhibitionism: A Handbook
Authors: L. Clovis Hirning
Journal: JAMA (1965)

The title brings together two quite unrelated clinical conditions which, the authors explain, are the most common sexual offenses. This creates an ambiguity, suggesting that there is a causal relation between the two conditions, comparable to writing a book on "cancer and heart disease" simply because they might be the most common causes of death. We are really dealing here with two separate books, something the title ought to reflect more clearly. There are 96 pages devoted to pedophilia and 58 devoted to exhibitionism. The remainder consists of appendices. The volume, representing the collaboration of three people of diverse disciplines, justifies in many ways the term "handbook," if we consider it a source of information, particularly statistical information. The book has many tables and graphs, with all kinds of interesting facts concerning the offender, the victim, the offenses, and the like. There is an implied objective, which may be inferred
Free Care, Cholestyramine, and Health Policy
Authors: David U. Himmelstein, Steffie Woolhandler
Journal: New England Journal of Medicine (1984)

Over the past decade the efficacy and cost of medical interventions have been subject to increasing scrutiny with quantitative techniques, such as the randomized controlled trial and cost-effectiveness analysis. Such studies provide invaluable guidance for the clinician choosing from a limited range of options in caring for an individual patient. However, in the field of health policy myriad competing programs, services, institutions, and interests must be weighed. Unfortunately, quantitative methods are virtually always used to compare two, or at most a few, alternative strategies. Since the relative cost effectiveness of an intervention may appear radically different depending on the alternative . . .
Abstract 1390: In vivo tracking of cancer-cell-derived exosomes
Authors: Kimi Homma, Atsushi Suetsugu, Takahiro Ochiya, Robert M. Hoffman
Journal: Cancer Research (2012)

Abstract The goal of the present study was to determine if exosomes play a role in cell-to-cell communication to promote tumor metastasis. Green fluorescence protein (GFP) was linked to CD63, which is a general marker of exosomes, in order to track breast-cancer-cell-derived exosomes cancer in nude mice. Breast cancer cells transferred their own exosomes to other cancer cells and normal lung tissue cells in culture. In the nude mouse, breast cancer cells secreted GFP exosomes into the tumor micro environments as well as the circulation. Numerous GFP in exosomes were visualized in breast cancer metastases in nude mice. The results of this study suggest that tumor-derived exosomes may contribute to formation of a niche to promote metastasis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1390. doi:1538-7445.AM2012-1390
Institute of Medicine Medical Error Figures Are Not Exaggerated
Authors: Lucian L. Leape
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Colonial Morphology Of Neisseria gonorrhoeae
Authors: B. B. Diena
Journal: JAMA (1974)

To the Editor.—  We have read recently with great interest the article by Brown and Kraus (228:862, 1974) regarding the recognition of the five colony types of Neisseria gonorrhoeae . The color photography truly enhances the morphological differences of the colony types.  Our observations agree with those of Brown and Kraus, and we are happy that, for the first time, there has been a clear indication in the literature of dark and light types 1 and 2. We have previously found type 1 and 2 gonococci to have variants, and we have designated the lighter variants types la and 2a. Under our experimental conditions, each of the colony types 1, la, 2, and 2a has reproduced true to the characteristics of the original types, and was shown, therefore, to be a stable variant .  Of interest to us, and not previously mentioned, is the fact that on prolonged incubation, types 1 and
Gastric mucosal mast cells in atopic subjects
Authors: G. F. Bagnato, E. Di Cesare, R. A. Caruso, S. Gulli, A. Cugliari, A. Morabito Lo Prete, M. Previti, M. Muscarà, M. Bottari
Journal: Allergy (1995)

Intragastral allergen provocation under endoscopic control (IPEC) allows direct observation of gastric mucosa reactions after contact with inhalant allergens that reach the stomach. We selected patients with proved atopy to Parietaria but without clinical and endoscopic signs of gastric disease, and we tested them with the specific inhalant allergen during IPEC, recording gastric macroscopic reaction and mucosal mast‐cell changes in biopsy specimens. All atopic patients showed visible changes in gastric mucosa quantified as IPEC score. Mast‐cell numbers detected in atopic patients (135.4 ± 102.6/mm 2 of stromal area) were significantly higher than in nonatopic subjects (59.8 ± 25.4/mm 2 ; P &lt;0.03) and were positively correlated to atopic IPEC score ( P &lt;0.01). In addition, 6/12 atopics who had both higher mast‐cell counts and IPEC score showed an intraepithelial distribution of gastric mast cells which displayed ultrastructural features of partial degranulation. It is likely that changes observed in our patients with allergy to Parietaria reflect a subclinical activation of mast cells in the gastric mucosa.
Cashew nut causes more severe reactions than peanut: case‐matched comparison in 141 children
Authors: A. T. Clark, K. Anagnostou, P. W. Ewan
Journal: Allergy (2007)

Background: Cashew nut allergy is becoming common, but the risk of severe reactions in comparison with peanut allergy is unknown. Method: A case‐matching study of children with a recent history of a reaction after definite nut ingestion, with positive skin prick test. Children whose worst ever reaction was to cashew nut (cashew group), were matched with two children each whose worst ever reaction was to peanut (peanut group) for sex, age of reaction and presentation, amount ingested, and asthma. Severity of the worst clinical reactions to date was compared. Results: A total of 47 children in the cashew group were matched to 94 in the peanut group. There were no differences in clinical features between groups for matching criteria, except asthma (more prevalent in the peanut group). Wheezing and cardiovascular symptoms were reported more frequently during reactions in the cashew compared with the peanut group: odds ratios (OR) 8.4 (95% CI: 3.2–22.0) and 13.6 (95% CI: 5.6–32.8), respectively. The cashew group received intramuscular adrenaline more frequently: OR 13.3 (95% CI: 5.5–32.2). Overall, the OR for a severe reaction (severe dyspnoea and/or collapse) in the cashew group was 25.1 (95% CI: 3.1–203.5). Conclusions: Previous studies show cashew nut can cause severe reactions; this is the first study to show by case‐matching that severe clinical reactions occur more frequently in cashew compared with peanut allergy. The nut type which caused the worst reaction to date should be considered when providing emergency medication.
Sarcoidosis associated with vemurafenib
Authors: A. Adam, L. Thomas, N. Bories, D. Zaharia, B. Balme, N. Freymond, S. Dalle
Journal: British Journal of Dermatology (2013)

Journal Article Sarcoidosis associated with vemurafenib Get access A. Adam, A. Adam Unit of Dermatology Centre Hospitalier Lyon‐Sud, Hospices Civils de Lyon 165 chemin du grand Revoyet 69495 Pierre‐ Bénite FranceUniversité Claude Bernard Lyon 1 Faculté de Médecine Lyon‐Est 8 avenue de Rockefeller 69008 Lyon France Search for other works by this author on: Oxford Academic Google Scholar L. Thomas, L. Thomas Unit of Dermatology Centre Hospitalier Lyon‐Sud, Hospices Civils de Lyon 165 chemin du grand Revoyet 69495 Pierre‐ Bénite FranceUniversité Claude Bernard Lyon 1 Faculté de Médecine Lyon‐Est 8 avenue de Rockefeller 69008 Lyon France Search for other works by this author on: Oxford Academic Google Scholar N. Bories, N. Bories Unit of Dermatology Centre Hospitalier Lyon‐Sud, Hospices Civils de Lyon 165 chemin du grand Revoyet 69495 Pierre‐ Bénite France Search for other works by this author on: Oxford Academic Google Scholar D. Zaharia, D. Zaharia Unit of Dermatology Centre Hospitalier Lyon‐Sud, Hospices Civils de Lyon 165 chemin du grand Revoyet 69495 Pierre‐ Bénite FranceUniversité Claude Bernard Lyon 1 Faculté de Médecine Lyon‐Est 8 avenue de Rockefeller 69008 Lyon France Search for other works by this author on: Oxford Academic Google Scholar B. Balme, B. Balme Unit of Pathology and Unit of Pneumonology Hospices Civils de Lyon Centre Hospitalier Lyon‐Sud 165 chemin du grand Revoyet 69495 Pierre‐Bénite France Search for other works by this author on: Oxford Academic Google Scholar N. Freymond, N. Freymond Unit of Pathology and Unit of Pneumonology Hospices Civils de Lyon Centre Hospitalier Lyon‐Sud 165 chemin du grand Revoyet 69495 Pierre‐Bénite France Search for other works by this author on: Oxford Academic Google Scholar S. Dalle S. Dalle Unit of Dermatology Centre Hospitalier Lyon‐Sud, Hospices Civils de Lyon 165 chemin du grand Revoyet 69495 Pierre‐ Bénite FranceUniversité Claude Bernard Lyon 1 Faculté de Médecine Lyon‐Est 8 avenue de Rockefeller 69008 Lyon FranceCancer Research Center of Lyon 8 avenue de Rockefeller 69008 Lyon France Correspondence: Stéphane Dalle. E‐mail: stephane.dalle@chu-lyon.fr Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 169, Issue 1, 1 July 2013, Pages 206–208, https://doi.org/10.1111/bjd.12268 Published: 01 July 2013
Do it yourself cardioversion.
Authors: J. A. McKnight, K. Balnave, D. B. O'Keeffe
Journal: BMJ (1988)

Medical history taking sometimes elicits unusual and interesting stories.Patients' perceptions and managements of their problems before they seek medical attention can produce some surprises.Unusual remedies that work may later be explained bv accepted medical logic.This is certainly true of the case reported here.
Lower Limb Amputation and the Diabetic Foot
Authors: S. W. Balkin
Journal: JAMA (1995)

<h3>To the Editor.</h3> —The figure consistently quoted as the number of lower extremity amputations among patients with diabetes in the United States is around 50000 yearly.<sup>1</sup>Without further clarification, use of this single figure misleads the less informed by leaving an erroneous perception of lost feet or limbs. A breakdown of lower extremity amputations by anatomic site puts this major complication in perspective. Using a 10-year aggregate (1983 to 1992), the National Center for Health Statistics shows a yearly mean of 51 434 nontraumatic amputations in nonfederal short-stay hospitals (unpublished data, Centers for Disease Control and Prevention, June 1994). However, the figure not generally reported is that 51% of that total represents lost toes (39%) and forefoot (12%), neither of which requires prostheses or rehabilitation. Data also show a yearly mean of 47% of amputations were at the knee, 28% below and 19% above. There was an overall decrease
Effects of Beer on Breast-fed Infants-Reply
Authors: Sheila B. Blume
Journal: JAMA (1993)

<h3>In Reply.</h3> —I read Drs Mennella and Beauchamp's contribution to the debate about beer and lactation with interest. In my reply to a question about prescribing beer to breast-feeding mothers, I remarked that the possible long-term effects of early exposure to small amounts of ethanol in infants were unknown, but that physicians should be wary about<i>ever</i>prescribing alcohol as a drug to their patients for<i>any</i>indication. Since that reply was written, Little and colleagues<sup>1</sup>reported on a study of the relationship between child development at age 1 year and postnatal alcohol intake (through breast-feeding). The subjects were 400 infants born to members of a health maintenance organization, primarily white, middle-class, educated women. An estimate was made of each infant's total exposure to alcohol through breast milk, based on maternal intake and the number of days of breast-feeding for each month. The findings were controlled for levels of
WARNING ON USE OF PHENOL-CAMPHOR IN CASES OF "ATHLETE'S FOOT"
Authors: Herbert O. Calvery
Journal: JAMA (1942)

<h3>To the Editor:—</h3> I was pleased to note in the current issue ofThe Journalyour comments on phenol-camphor for "athlete's foot," especially since it warns again that the phenol-camphor preparation should not be applied to the wet skin. Our previous experience with phenol-camphor mixtures caused us to be a little bit dubious about the clinical note which appeared inThe Journalof Dec. 6, 1941, but we did not immediately begin any investigations of these preparations and, as a matter of fact, did not perform any experiments until a casecame to our attention which resulted from the appearance of an item in<i>Science Supplement</i>of Dec. 19, 1941. In the item in<i>Science Supplement</i>it states: "The remedy consists of a mixture of three parts phenol and one part camphor which can be prepared by any pharmacist." The injury which came to our attention, as I said, was the
Association of Androgenetic Alopecia With Mortality From Diabetes Mellitus and Heart Disease
Authors: Lin-Hui Su, Li-Sheng Chen, Sheng-Che Lin, Hsiu-Hsi Chen
Journal: JAMA Dermatology (2013)

Identifying predictors of mortality from diabetes mellitus (DM) and heart disease can help shape treatment strategies. Presence of androgenetic alopecia (AGA) might be such a predictor.To determine whether the presence of AGA is associated with an elevated rate of mortality from DM and heart disease in both sexes after adjustment for potential confounders.A population-based prospective cohort study.Community-based integrated screening in Taiwan.A total of 7252 subjects aged 30 to 95 years participated in the baseline AGA survey using the Norwood and Ludwig classifications between April and June 2005. Baseline information on metabolic syndrome (MetS) and other possible risk factors was also collected. We then followed this cohort over time to ascertain death and cause of death until December 2010. INTERVENTIONS OR EXPOSURES: Application of Norwood and Ludwig ALA classifications to study population.Deaths from DM and heart disease.Among the 7126 subjects (2429 men and 4697 women) who provided complete data, there were 70 deaths from DM and heart disease during the 57-month follow-up period. Subjects with moderate to severe AGA vs normal or mild AGA had a significantly higher risk of mortality from DM (adjusted hazard ratio [HR], 2.97; 95% CI, 1.26-7.01) (P = .01) and heart disease (adjusted HR, 2.28; 95% CI, 1.00-5.23) (P = .05) after adjusting for age, family history of DM or heart disease, and MetS.AGA is an independent predictor of mortality from DM and heart disease in both sexes. This finding may have significant implications for the identification of risk factors for DM and heart disease in patients with moderate or severe AGA, regardless of whether MetS is present.
Gene Therapy: Suppression of VEGF by Reversible‐PEGylated Histidylated Polylysine in Cancer Therapy (Adv. Healthcare Mater. 11/2014)
Authors: Xiaojun Cai, Haiyan Zhu, Haiqing Dong, Yongyong Li, Jiansheng Su, Donglu Shi
Journal: Advanced Healthcare Materials (2014)

On page 1818, Y. Y. Li, D. Shi, and co-workers show that reversible PEGylation and histidylation of polylysine catiomer critically function to facilitate the efficient delivery of siRNA-VEGF. The unique structural designs significantly affect the gene transfection efficiencies both in vitro and in vivo, and further result in effective inhibition of tumor growth on the murine xenograft models.
445 A PHASE 2B TRIAL COMPARING 24 TO 48 WEEKS TREATMENT WITH TEGOBUVIR (GS-9190)/PEG/RBV TO 48 WEEKS TREATMENT WITH PEG/RBV FOR CHRONIC GENOTYPE 1 HCV INFECTION
Authors: E. Lawitz, I. Jacobson, E. Godofsky, G.R. Foster, R. Flisiak, M. Bennett, M. Ryan, J. Hinkle, J. Simpson, J. McHutchison, D. Oldach
Journal: Journal of Hepatology (2011)