Pressor Amines and the Carcinoid Flush
Authors: ROBERT J. LEVINE
Journal: Annals of Internal Medicine (1963)

Article1 May 1963Pressor Amines and the Carcinoid FlushROBERT J. LEVINE, M.D., ALBERT SJOERDSMA, M.D., PH.D.ROBERT J. LEVINE, M.D., ALBERT SJOERDSMA, M.D., PH.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-5-818 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt is generally accepted that overproduction of serotonin accounts for the major symptomatology of patients with the malignant carcinoid syndrome. When flushing reactions occur, however, certain facts lead one to question the primacy of serotonin in pathogenesis. With occasional exceptions (1, 2), it has not been possible to demonstrate increased concentrations of serotonin in association with spontaneous or induced flushes in carcinoid patients. Also, we have observed severe flushing in patients who had only slightly increased concentrations of the serotonin end-product, 5-hydroxyindoleacetic acid (5HIAA). Furthermore, it is difficult to induce flushes with serotonin, and those that are induced differ qualitatively...References1. PEARTANDREWSROBERTSON WSTMJI: Serotonin release induced with intravenous adrenaline or noradrenaline. Lancet 1: 577, 1961. CrossrefMedlineGoogle Scholar2. ROBERTSONPEARTANDREWS JIWSTM: The mechanism of facial flushes in the carcinoid syndrome. Quart. J. Med. 31: 103, 1962. MedlineGoogle Scholar3. STACEY RS: Malignant carcinoid tumors. Proc. Roy. Soc. Med. 50: 40, 1957. CrossrefMedlineGoogle Scholar4. SCHNECKLOTHPAGEDEL GRECOCORCORAN RIHFAC: Effects of serotonin antagonists in normal subjects and in patients with carcinoid tumors. Circulation 16: 523, 1957. CrossrefMedlineGoogle Scholar5. PEARTROBERTSONANDREWS WSJITM: Facial flushing produced in patients with carcinoid syndrome by intravenous adrenaline and noradrenaline. Lancet 2: 715, 1959. CrossrefMedlineGoogle Scholar6. LINDENEGFABRICIUS OJ: Carcinoid syndrome. Lancet 2: 108, 1961. CrossrefGoogle Scholar7. 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SJOERDSMAWEISSBACHUDENFRIEND AHS: A clinical, physiologic and biochemical study of patients with malignant carcinoid. Amer. J. Med. 20: 520, 1956. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROBERT J. LEVINE, M.D.; ALBERT SJOERDSMA, M.D., PH.D.Affiliations: Bethesda, MarylandFrom the Experimental Therapeutics Branch, National Heart Institute, National Institutes of Health, Bethesda, Maryland.This paper was presented in part at the Forty-third Annual Session of the American College of Physicians, Philadelphia, Pennsylvania, April 9-13, 1962.Requests for reprints should be addressed to Albert Sjoerdsma, M.D., Ph.D., Experimental Therapeutics Branch, National Heart Institute, National Institutes of Health, Bethesda 14, Maryland. 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MENGEL, M.D.THE RELEASE OF CHEMICAL SUBSTANCES FROM THE PULMONARY AND BRONCHIAL CIRCULATIONEditorialsRELEASE OF A KININ PEPTIDE IN THE CARCINOID SYNDROME 1 May 1963Volume 58, Issue 5Page: 818-828KeywordsAttentionBlood plasmaExcretionHeartIsoproterenolPathogenesisSerotonin ePublished: 1 December 2008 Issue Published: 1 May 1963 PDF downloadLoading ...