tbuckley/cabot-search huggingface dataset:
Genomic Alterations in Human Malignant Glioma Cells Associate with the Cell Resistance to the Combination Treatment with Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand and Chemotherapy
Authors: Yueh-Chun Li, Ching-Cherng Tzeng, Jin H. Song, Fuu-Jen Tsia, Lie-Jiau Hsieh, Shu-Ju Liao, Chang-Hai Tsai, Erwin G. Van Meir, Chunhai Hao, Chyi-Chyang Lin
Journal: Clinical Cancer Research (2006)

Abstract Purpose: Tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) is currently under clinical development as a cancer therapeutic agent. Many human malignant glioma cells, however, are resistant to TRAIL treatment. We, therefore, investigated the genomic alterations in TRAIL-resistant malignant glioma cells. Experimental Design: Seven glioma cell lines and two primary cultures were first analyzed for their sensitivity to TRAIL and chemotherapy and then examined for the genomic alterations in key TRAIL apoptotic genes by comparative genomic hybridization (CGH), G-banding/spectral karyotyping, and fluorescence in situ hybridization (FISH). Results: CGH detected loss of the chromosomal regions that contain the following genes: 8p12-p23 (DR4 and DR5), 2q33-34 (caspase-8), 11q13.3 (FADD), 22q11.2 (Bid), and 12q24.1-q24.3 (Smac/DIABLO) in TRAIL-resistant cell lines. Spectral karyotyping showed numerical and structural aberrations involving the chromosomal regions harboring these genes. A combination of G-banding/spectral karyotyping and FISH further defined the loss or gain of gene copy of these genes and further showed the simultaneous loss of one copy of DR4/DR5, caspase-8, Bid, and Smac in two near-triploid cell lines that were resistant to the combination treatment with TRAIL and chemotherapy. Loss of the caspase-8 locus was also detected in a primary culture in correlation with the culture resistance to the combined TRAIL and chemotherapy treatment. Conclusions: The study identifies chromosomal alterations in TRAIL apoptotic genes in the glioma cells that are resistant to the treatment with TRAIL and chemotherapy. These genetic alterations could be used to predict the responsiveness of malignant gliomas to TRAIL-based therapies in clinical treatment of the tumors.
The Use of Literary Classics in Teaching Medical Ethics to Physicians
Authors: Steven M. Radwany
Journal: JAMA (1987)

The "Great Books Course in Medical Ethics" offered by the Department of Medicine of Evanston Hospital in Evanston, Illinois, is described. The course, a series of monthly seminars for attending staff and medical house staff, is intended as a forum in which great works of literature serve as the springboard for exploring issues of clinical medical ethics. It is taught by an experienced Great Books discussion leader, assisted by an ethicist, a philosopher, and a clinical nephrologist. Participants in the seminars have found them beneficial in enhancing their analytical skills for addressing ethical problems. The course is extracurricular; evaluation is nonstructured and based on participant feedback, which is discussed in the article.
Alloimmune neonatal thrombocytopenia associated with incidental maternal thrombocytopenia
Authors: Robert F. Burrows, John G. Kelton
Journal: American Journal of Hematology (1990)

Abstract In this report, we describe a mother with mild incidental thrombocytopenia who delivered a severely thrombocytopenic infant having alloimmune thrombocytopenia. This coincidental association should be considered because the recognition and proper diagnosis of alloimmune neonatal thrombocytopenia is important, not only in the current pregnancy, but also in future pregnancies.
The case against distributed representations: Lack of evidence
Authors: Simon Farrell, Stephan Lewandowsky
Journal: Behavioral and Brain Sciences (2000)

We focus on two components of Page's argument in favour of localist representations in connectionist networks: First, we take issue with the claim that localist representations can give rise to generalisation and show that whenever generalisation occurs, distributed representations are involved. Second, we counter the alleged shortcomings of distributed representations and show that their properties are preferable to those of localist approaches.
Acute Myocardial Infarction in Doncaster. I--Estimating Size of Coronary Care Unit
Authors: H. C. Smyllie, M. P. Taylor, R. A. Cuninghame-Green
Journal: BMJ (1972)

A "no refusal" coronary care service (for one year) was offered to a selected sample of 10 general practices (total list 74,657). The patients were admitted to a three-bedded unit in Doncaster Royal Infirmary and data were collected to enable estimation of the size of unit necessary to serve the whole population in the area (census estimate 268,560; total G.P. list 315,811). This estimation was based on:1. The frequency of admission to hospital of suspected acute myocardial infarction in one year, estimated at 978 from the total population.2. The average duration of stay in the unit, which was 2.45 days.3. The distribution of observed occupancy was approximately Poissonian.From these the average expected bed occupancy was calculated as 6.56 and reference to probability tables gave the frequency of overload for different numbers of beds provided. The incidence of acute myocardial infarction in the area is estimated at 275 per 100,000 per annum, on calculations based on the practice list size, and at 323 per 100,000 per annum, on calculations based on census figures.
Involved-Field Radiotherapy for Advanced Hodgkin's Lymphoma
Authors: Berthe M.P. Aleman, John M.M. Raemaekers, Umberto Tirelli, Roberto Bortolus, Mars B. van 't Veer, Marnix L.M. Lybeert, Jo J. Keuning, Patrice Carde, Théodore Girinsky, Richard W.M. van der Maazen, Radka Tomšič, Marjeta Vovk, Achilles van Hoof, Geertrui Demeestere, Pieternella J. Lugtenburg, José Thomas, Wilfried Schroyens, Koenraad De Boeck, Johanna W. Baars, Johanna C. Kluin-Nelemans, Christian Carrie, Malek Aoudjhane, Dominique Bron, Houchingue Eghbali, Wilma G.J.M. Smit, Jacobus H. Meerwaldt, Anton Hagenbeek, Antonella Pinna, Michel Henry-Amar
Journal: New England Journal of Medicine (2003)

The use of involved-field radiotherapy after chemotherapy for advanced Hodgkin's lymphoma is controversial.
Specific IgG, but not specific IgE, antibodies to toluene diisocyanate–human serum albumin conjugate are associated with toluene diisocyanate bronchoprovocation test results
Authors: Hae-Sim Park, Hee-Yeon Kim, Dong-Ho Nahm, Jee-Woong Son, You-Young Kim
Journal: Journal of Allergy and Clinical Immunology (1999)
Effects of two antihistamine drugs on actual driving performance.
Authors: A F Cohen, J Posner
Journal: BMJ (1984)

Case reports CASE 1The patient was a 19 year old previously healthy man who was injured while ski jumping and sustained complete tetraplegia.X ray examinations disdosed fractures of C4 and C5.On admission to hospital he had normal serum concentrations of calcium, phosphate, creatinine, and parathyroid and thyroid hormones.Repeated chest x ray films were normal, as were x ray films of the skull, lumbar spine, and pelvis.
Dietary Fiber and Coronary Heart Disease Prevention
Authors: Gema Frühbeck
Journal: JAMA (1996)

<h3>To the Editor.</h3> —I eagerly read the article by Dr Rimm and colleagues<sup>1</sup>in which the authors concluded that "fiber, independent of fat intake, is an important dietary component for the prevention of coronary disease." These important findings will probably lead to behavioral changes both in the population and in physicians' dietary prescriptions. The food industry also will be urged to develop products to increase fiber intake and to provide product labeling that addresses the fiber content in a more detailed way. However, there is another issue that should be considered and that Rimm and colleagues acknowledge: "We cannot conclusively exclude the possibility that some unknown factor associated with high fiber intake is responsible for the reduction in coronary disease. However, this unknown factor would need to be strongly associated with risk of coronary disease." It is well known that foods with high fiber content are rich in phytic
Inhibition of factor Xa-mediated procoagulant activity of human lung fibroblasts and pleural mesothelial cells
Authors: A Kumar, KB Koenig, AR Johnson, DS Fair, S Idell
Journal: European Respiratory Journal (1995)

Extravascular fibrin deposition characterizes diverse forms of lung and pleural injury. Fibrin formation in these compartments is locally potentiated by the assembly and expression of the prothrombinase procoagulant complex (factors Xa, Va and II) at the surface of human lung fibroblasts and pleural mesothelial cells. We sought to identify structural domains on factor Xa that mediate expression of prothrombinase activity by these cells. In order to accomplish this objective, we used panels of monoclonal antibodies (MoAbs) to factor X to block prothrombinase assembly and function on the surface of cultured human lung fibroblasts and pleural mesothelial cells. Of 30 factor X MoAbs that recognized native factors X and Xa, 10 completely inhibited factor Xa function (prothrombin activation), and five others neutralized Xa function without affecting cell-binding, presumably by blocking the prothrombin binding site. Western blots showed that these inhibitory MoAbs reacted with the Xa heavy-chain. One MoAb that recognized the factor Xa light-chain blocked prothrombin activation at the factor Va binding site. Our results indicate that prothrombinase activity at the surface of lung parachymal or pleural cells can be blocked by MoAbs that interact with either the heavy- or light-chain of factors X. Antibodies that neutralize cell surface-expressed prothrombin activation offer a potential means to arrest pericellular fibrin formation in the lung and pleural space.
A common haplotype of the IL-31 gene influencing gene expression is associated with nonatopic eczema
Authors: Florian Schulz, Ingo Marenholz, Regina Fölster-Holst, Christiane Chen, Alexander Sternjak, Ria Baumgrass, Jorge Esparza-Gordillo, Christoph Grüber, Renate Nickel, Stefan Schreiber, Monika Stoll, Michael Kurek, Franz Rüschendorf, Norbert Hubner, Ulrich Wahn, Young-Ae Lee
Journal: Journal of Allergy and Clinical Immunology (2007)
Clinical and immunological evidence that low doses of pentavalent antimonials are effective in maintaining long‐term cure of <i>Leishmania (Viannia) braziliensis</i> cutaneous lesions
Authors: R. Vieira‐Gonçalves, R.S. Nogueira, J.F. Heringer, C.O. Mendes‐Aguiar, A. Gomes‐Silva, J.R. Santos‐Oliveira, M.P. Oliveira‐Neto, A.M. Da‐Cruz
Journal: British Journal of Dermatology (2015)
Mediation of liability claims
Authors: R. P. Bergen
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A CASE OF KERATODERMIA BLENNORRHAGICA
Authors: ROBERT GIBSON
Journal: British Journal of Dermatology (1923)

Journal Article A CASE OF KERATODERMIA BLENNORRHAGICA Get access ROBERT GIBSON, M.D. ROBERT GIBSON, M.D. Hon. Dermatologist, Salford Royal Hospital; Hon. Assistant Physician, Manchester and Salford Hospital for Skin Diseases Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 35, Issue 4, 1 April 1923, Page 151, https://doi.org/10.1111/j.1365-2133.1923.tb09098.x Published: 01 April 1923
Diastolic bulging of the interventricular septum toward the left ventricle. An echocardiographic manifestation of negative interventricular pressure gradient between left and right ventricles during diastole.
Authors: H Tanaka, C Tei, S Nakao, M Tahara, S Sakurai, T Kashima, T Kanehisa
Journal: Circulation (1980)

Diastolic bulging of the interventricular septum (IVS) toward the left ventricle was observed by real-time cross-sectional echocardiography in three patients with primary pulmonary hypertension and one patient with secondary pulmonary hypertension after closure of an atrial septal defect. M-mode echocardiography showed a characteristic abnormal pattern of septal motion in diastole and in systole. In two patients, we attempted to correlate M-mode motion to the interventricular pressure gradient. During diastole, the interventricular pressure gradient between the left and right ventricles was negative and the pressure gradient curve was very similar to the M-mode echogram of the IVS. Banding studies in which acute right ventricular hypertension was produced in dogs showed similar shape changes, suggesting that the diastolic shape and motion of the septum are determined by the interventricular pressure gradient between the ventricles. Diastolic bulging of the IVS toward the left ventricle in our patients results from negative interventricular pressure gradient between the left and right ventricles during diastole.
Genomics and complex liver disease: Challenges and opportunities
Authors: Brian D. Juran, Konstantinos N. Lazaridis
Journal: Hepatology (2006)

The concept of genetic susceptibility in the contribution to human disease is not new. What is new is the emerging ability of the field of genomics to detect, assess, and interpret genetic variation in the study of susceptibility to development of disease. Deciphering the human genome sequence and the publication of the human haplotype map are key elements of this effort. However, we are only beginning to understand the contribution of genetic predisposition to complex liver disease through its interaction with environmental risk factors. In the coming decade, we anticipate the development of human studies to better dissect the genotype/phenotype relationship of complex liver diseases. This endeavor will require large, well-phenotyped patient populations of each disease of interest and proper study designs aimed at answering important questions of hepatic disease prognosis, pathogenesis, and treatment. Teamwork between patients, physicians, and genomics scientists can ensure that this opportunity leads to important biological discoveries and improved treatment of complex disease.
Use and abuse of psychiatric testimony.
Authors: D Chiswick
Journal: BMJ (1985)

Most of the principles that govern the physician patient relationship are altered in the forensic psychiatric situation where the physician's principal obligation is to the referring agent, prosecution, defense, or court. Chiswick, a senior lecturer in forensic psychiatry at the Royal Edinburgh Hospital, identifies three issues which may lead to misuse of legitimate psychiatric testimony--difficulty in evaluating the testimony as compared to other forensic evidence, the limits of psychiatry in determining diminished responsibility and dangerousness, and the extent to which the physician will follow his "ethical conscience." The author urges forensic psychiatrists to define the limits and relevance of their skills in order to preserve their professional and ethical standards.
EVALUATION OF SKIN GRAFT VIABILITY USING XE-133 SALINE CLEARANCE RATES
Authors: Stephen R. Bunker, Jaykumar C. Patel, Thomas E. Smith, Michael F. Hartshorne, Robert D. Karl, Michael A. Cawthon, William H. Howard
Journal: Clinical Nuclear Medicine (1983)

Bunker, Stephen R.; Patel, Jaykumar C.; Smith, Thomas E.; Hartshorne, Michael F.; Karl, Robert D. Jr.; Cawthon, Michael A.; Howard, William H. III Author Information
Pneumocystis carinii pneumonia. Needle-biopsy diagnosis and successful treatment
Authors: J. P. Lillehei
Journal: JAMA (1968)

Respiratory symptoms and diffuse pulmonary infiltrate developed in two patients under treatment for leukemia.<i>Pneumocystis carinii</i>pneumonia was suspected and then confirmed by open-lung biopsy in one and by percutaneous needle biopsy of the lung in the other. Both patients recovered promptly from the pneumonia during a 10- to 14-day course of treatment with intramuscularly administered pentamidine isethionate. In both patients hypoglycemia occurred during treatment, and subcutaneous abscesses at the drug injection sites developed in one patient.
Geriatric medicine and disabled living.
Authors: J F Harrison
Journal: BMJ (1981)

Forty-one couples facing the prospect of separation by death were interviewed about how the nature and prognosis of their illness had been discussed with them by their general practitioner hospital staff, and the staff of the continuing care unit to which they were admitted.Communication between husband and wife and how they coped with telling their parents and their children was also assessed.Treatment was given when they were anxious or dissatisfied about the quality of communication in any of these areas.The couples found hospital doctors least successful at communication.Almost all who were dissatisfied wanted more information, not less.The wish to protect dependent relatives conflicted with the wish to be open, making decisions very difficult.Considerable suffering is caused by poor communication, and much of this is avoidable.
NICE recommends same day surgery for hip fracture patients
Authors: S. Mayor
Journal: BMJ (2011)

Patients with hip fracture should undergo surgery the same day or the day after hospital admission and undergo a coordinated programme to prevent long term disability and complications, recommends guidance from the National Institute for Health and Clinical Excellence.

Current outcomes for the 70 000 to 75 000 people each year in the United Kingdom who have a hip fracture are poor, with about 10% of people dying within one month and one third dying within 12 months of the fracture. Most of these deaths are not caused by the hip fracture itself but by pre-existing illness, so the new guideline proposes measures to diagnose …
Perspectives in Neurological Surgery
Authors: Dawn Bick
Journal: JAMA (1993)

<i>Perspectives in Neurological Surgery</i>, edited by Daniel L. Barrow of the Division of Neurosurgery, Department of Surgery, at Emory University, is a new series of reviews by noted authors on a wide variety of subjects dealing with all major aspects of neurological surgery. The editorial board consists of an optimal mixture of leading senior neurosurgeons and young, up and coming, yet experienced junior neurosurgical faculty. Considering the large number of currently available neurosurgically oriented periodicals,<i>Perspectives in Neurological Surgery</i>is rather unique in its scope and perspective. To paraphrase the preface from the first issue, this periodical is neither a journal nor a book. Each hardbound issue is a combination of in-depth reviews of particular topics of contemporary interest and a variety of shorter, highly focused articles. Each issue includes a section entitled "Feature," which contains primarily comprehensive subject reviews. Other sections are "Focus on Technique," describing detailed preoperative, operative,
Studies on Hepatic Dysfunction: I. Carbon Tetrachloride Poisoning
Authors: J. Beattie, P. H. Herbert, C. Wechtel, C. W. Steele
Journal: BMJ (1944)

The interest of the case, recorded below lies in the success- ful use of a method of treatment not hitherto applied to man.It was felt that the following considerations, which seemed to indicate a probably fatal outcome, justified its adoption: (1) The large quantity of carbon tetrachloride alleged to have been swallowed-30 to 40 ml.The maxi- mum therapeutic dose is 4 ml., but fatalities have been reported with doses as low as 1.5 ml.(2) The probably complete absorption of the drug.Immediate symptoms indicated a rapid entry into the circulation.Vomiting was not induced until 45 minutes after ingestion.(3) The speed with which the liver enlarged.(4) The delay of 19 hours between the accident and the institution of treatment. Case HistoryAn Army Air Force sergeant-pilot (white) aged 23 ingested by mis- take " two large swallows ' of carbon tetrachloride at 4.15 p.m. on Oct. 2. 1943.The quantity was determined later to be between 30 and 40 ml.No food had been taken since breakfast at 7.15 a.m.The patient noted an immediate " hot burning sensation " in his " throat and stomach."He became rapidly " dizzy and lightheaded," but was able to walk with assistance to the camp infirmary.At 4.35 p.m. he was given large quantities of salt and water by mouth to induce vomiting.This did not occur until 45 minutes after the accident, and was not repeated.The medical officer observed that at this time the patient was confused mentally, and subsequent questioning revealed that there had been a loss of memory of events between his arrival at the camp infirmary and his transfer to hospital at 6.30 p.m. On admission to hospital he was put to bed and given 1+ gr. of luminal to alleviate his apprehen- sion and restlessness.He was still dizzy and nauseated throughout the night, but vomited only once.He refused food on the evening of admission and on the morning of the following day-Oct. 3.At 11 a.m. on Oct. 3 he came under our observation.One of us (W.) examined the patient, who was restless and complained of dizziness.Jerking movements of the limbs and rolling of the head from side to side were observed.The pharynx was red and injected.Abdominal palpation revealed a tender liver with rounded edge.This edge extended 2 in.below the costal margin in the right anterior axillary line and 11 in.below the costal margin in the left anterior axillary line.It was also palpated 1 in.above the umbilicus.All these and subsequent measurements were taken during normal respiration, and were confirmed by three observers.No other abnormal signs or symptoms were noted.At 12.30 p.m. the patient was given 2 g. of dl-methionine by mouth.This was retained.At 3.30 p.m. 1 ml. of a casein-digestmethionine solution was injected slowly into an antecubital vein.There was no immediate reaction.Five minutes later 5 ml.was injected, also without reaction.Continuous infusion of the solution by a Murphy drip apparatus was begun immediately.The rate of infusion was about 2 ml.a, minute.At 6.30 p.m., when 436 ml. of