tbuckley/cabot-search huggingface dataset:
Clinical Applications of Serum Guanase Determinations.
Authors: Cyrus Afrasiabi
Journal: Annals of Internal Medicine (1965)

s1 November 1965Clinical Applications of Serum Guanase Determinations.Cyrus Afrasiabi, M.D., James L. Whitehouse, M.S., Edwin M. Knights Jr., M.D., F.A.C.P.Cyrus Afrasiabi, M.D.Search for more papers by this author, James L. Whitehouse, M.S.Search for more papers by this author, Edwin M. Knights Jr., M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-5-909_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA new, highly sensitive liver function test has been developed to aid the clinical laboratory in providing information for the physician for the evaluation of the status of the liver. This test is based on measurement of serum guanase. Guanase, which participates in purine metabolism, is present in high concentration in the liver, but normally only negligible amounts can be found in the blood; thus it can provide an indication of the extent of liver cell damage by its concentration in serum of plasma.To be practical as a liver function test, a procedure must be easily performed by the... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Cyrus Afrasiabi, M.D.; James L. Whitehouse, M.S.; Edwin M. KnightsJr., M.D., F.A.C.P.Affiliations: Southfield, Michigan PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCarbohydrates 1 November 1965Volume 63, Issue 5Page: 909-909KeywordsAttentionBlood cellsBlood plasmaCell metabolismClinical laboratoriesLiverLiver function testsPlasma cellsPurine metabolism ePublished: 1 December 2008 Issue Published: 1 November 1965 PDF downloadLoading ...
BMA view on whistleblowing
Authors: M. Porter
Journal: BMJ (2009)

The question “What are doctors for?” has been considered in the BMJ on more than one occasion. The straightforward answer is that our fundamental responsibility is to provide care of the highest possible quality to our patients and do all we can to guarantee their safety—no matter what obligations we have to any other parties, including our employers.

The BMA’s guidance on whistleblowing recognises the huge …
PATHOLOGY OF THE PROSTATE
Authors: E. O. SMITH
Journal: JAMA (1913)

These cost items do not include distribution.The milk is in Cincinnati, the freight is paid, but the milk has not yet been distributed to the consumer.This certified milk is dis- tributed with the other milk.It is, therefore, impossible for us to distinguish the cost of distributing certified from other products.If we had nothing but certified milk it would be easier.Du. Otto Geier, Cincinnati: Will you analyze the cost of certification?Me. Miller: It includes cap and inspection by the veteri- narian, inspection by the bacteriologist and chemist
Total Distal Penile Necrosis Caused by Condom Catheter
Authors: George Steinhardt
Journal: JAMA (1980)

RECOGNITION of the long-term sequelae of indwelling urethral catheters has led to the increasing use of condom catheter drainage systems in paraplegic and geriatric populations. We present a case of penile necrosis caused by condom catheter and submit recommendations for the care of condom catheter systems. <h3>Report of a Case</h3> An 86-year-old man was discharged from an outlying hospital after recovering from a stroke that resulted in a left-sided hemiparesis. Because of unpredictable voiding, a condom catheter was applied before his discharge from that hospital. The patient was sent home under the care of his wife and daughter. Four days after discharge, the patient was brought to our emergency room because the end of his penis had turned black (Figure). The patient's family had not changed his condom catheter; they had received no instructions regarding its care. A punch cystostomy was performed to divert the urinary stream, and, after appropriate
The effect of intensive endurance exercise training on body fat distribution in young and older men
Authors: Robert S. Schwartz, William P. Shuman, Valerie Larson, Kevin C. Cain, Gilbert W. Fellingham, James C. Beard, Steven E. Kahn, John R. Stratton, Manuel D. Cerqueira, Itamar B. Abrass
Journal: Metabolism (1991)
Reply to Mohammad Issa Dauleh’s Letter to the Editor re: Sandra Lindstedt, Ulla Lindström, Eva Ljunggren, Björn Wullt and Magnus Grabe. Single-Dose Antibiotic Prophylaxis in Core Prostate Biopsy: Impact of Timing and Identification of Risk Factors. Eur Urol 2006;50:832–37
Authors: Magnus Grabe, Björn Wullt
Journal: European Urology (2007)
863. Liver Gene Therapy for Hemophilia with phiC31 Integrase
Authors: Lauren E. Woodard, Annahita Keravala, Robert T. Hillman, Julien Sage, Michele P. Calos
Journal: Molecular Therapy (2006)

The phiC31 integrase system effectively integrates plasmid DNA carrying an attB site into a limited number of endogenous pseudo attP sites in mammalian genomes, leading to robust, long_term expression of transgenes. The phiC31 system has been used to genetically engineer Drosophila and Xenopus and for in vivo and ex vivo gene therapy in several tissues in model organisms including mouse, rat, and rabbit. The integrase system appears to be well suited for long_term gene therapy in humans. In particular, the phiC31 system may allow long_term gene expression in hepatocytes in vivo.
Amantadine in Jakob-Creutzfeldt disease.
Authors: F H Norris
Journal: BMJ (1972)

chest pain radiating to both arms and asso- ciated with sweating.The E.C.G. showed a sinus tachycardia with occasional supraventricular extrasystoles and an inferior in- farct.Serial serum transaminases were raised.The next day she developed a rapid atrial fibrillation for which she was digitalized.However, the dysrhythmia persisted 18 hours and 10 mg verapamil were given intravenously over a period of 20 seconds.Within 10 minutes, her cardiac rate had decreased from 180 per minute to 120 per minute.A tracing at this time showed a
McAlpine's Multiple Sclerosis
Authors: Charles M. Poser
Journal: JAMA (1985)

The first edition of what was immediately hailed as the definitive book on multiple sclerosis appeared 30 years ago. Douglas McAlpine, Charles Lumsden, and Alexander Compston were the original authors. In a subsequent edition, entitled<i>Multiple Sclerosis: A Reappraisal</i>, E. D. Acheson replaced Compston. The present volume, appropriately perpetuating and honoring McAlpine's name, is not only a worthy successor, but is in fact even better than its already excellent predecessors. Once again this book should be considered the overall authority on most, if not all, aspects of multiple sclerosis. Only the sections on treatment and on neuroimaging require updating. An immense amount of data has been collected and critically appraised; applicability to the dayto-day management of patients has been evaluated with proverbial British reticence and common sense. In fact, it is these qualities that make the book so attractive. Acheson's discussion of the possible significance of the epidemiologic data should
Unexplained Steatorrhoea in the Syndrome of Hyponatraemia and Carcinoma of Bronchus
Authors: P. Turner, R. Williams
Journal: BMJ (1962)

BRONCHIAL CARCINOMA MBimns 287 Of patients undergoing resection for bronchial carcinoma, 41% may thus expect to survive for more than three years; and the five-year survival rate was 32.6%.Most patients doomed to a recurrence develop it within 12 months, and the great majority within two years.Patients who are well two years after operation are more likely to die of other natural causes than of metastasis.Of the five-year survivors five originally had adenocarcinomas, seven were anaplastic, and all the rest squamous.Palliative Measures Deep x-ray therapy is indicated as a palliative measure for (1) inoperable anaplastic growths, especially in patients under 45; (2) mediastinal obstruction; (3) Pancoast syndrome; (4) dysphagia; and (5) bone involvement by either primary or secondary growths.
Tumors of the Major and Minor Salivary Glands
Authors: R. J. McKenna
Journal: CA A Cancer Journal for Clinicians (1984)

Surgery for salivary gland tumors requires technical skill, competence in head and neck anatomy, and a familiarity with a variety of tumors. Benign salivary tumors at all sites should be 100 percent curable, with a local recurrence rate of less than five percent; these local failures should be curable with further surgery. The majority of parotid tumors are benign. Sixty-two percent of patients with malignant parotid tumors will be alive at five years, 54 percent at 10 years, and 47 percent at 15 years. These survival rates for malignant parotid tumors are better than those for malignant tumors in the submaxillary and minor salivary glands and may be explained in part by the presence of a higher percentage of low-grade malignant tumors in the parotid gland. Since most submaxillary gland tumors are malignant, they are more dangerous than parotid tumors. A total of 80 percent of patients with submaxillary gland tumors die as a result of cancer. Almost all minor salivary gland tumors are malignant; curability relates to size, local extension, histology, and nodal metastases. Forty-five percent are alive at five years, and 21 percent at 15 years. Wide-field radical surgical excision is needed for malignant salivary tumors to minimize local recurrences and treatment failures. Future improvement in treatment results will be made possible by increased awareness of this group of tumors, earlier diagnosis when tumors are still small, more radical extirpation, and greater use of postoperative radiation therapy.
Stem-Cell Transplantation in Myocardial Infarction: A Status Report
Authors: Michael S. Lee, Raj R. Makkar
Journal: Annals of Internal Medicine (2004)

Myocardial infarction is the leading cause of congestive heart failure and death in the industrialized world. Current therapy is limited in preventing the progression of ventricular remodeling and congestive heart failure. Recent interest has focused on stem cells, which are undifferentiated and pluripotent cells that can proliferate, potentially self-renew, and differentiate into cardiomyocytes. Myocardial regeneration with stem-cell transplantation is a possible treatment option to reverse the deleterious hemodynamic and neurohormonal effects that occur after myocardial infarction and can lead to congestive heart failure. Various preclinical animal studies show the potential to regenerate myocardium and improve perfusion to the infarct area to improve cardiac function but also suggest that stem cells may have proarrhythmic effects. Early phase I clinical studies indicate that stem-cell transplantation is feasible and may have beneficial effects on ventricular remodeling after myocardial infarction. Future randomized clinical trials will establish the magnitude of the benefit and the effects on arrhythmias after stem-cell therapy.
STENT DESIGN AFFECTS NEOINTIMAL GROWTH PATTERN IN BIFURCATION LESION AFTER STENT IMPLANTATION: OPTICAL COHERENCE TOMOGRAPHY STUDY
Authors: Takahiro Yoshimura, Masami Nishino, Naotaka Okamoto, Akihiro Tanaka, Atsushi Kikuchi, Takeshi Masaki, Naoki Mori, Daisuke Nakamura, Yasuharu Lee, Masayuki Taniike, Nobuhiko Makino, Hiroyasu Kato, Yasuyuki Egami, Ryu Shutta, Hisaki Morita, Jun Tanouchi, Yoshio Yamada
Journal: Journal of the American College of Cardiology (2011)
Facilitators and guidelines
Authors: K. Barraclough
Journal: BMJ (2002)

She beamed at us enthusiastically across the table. My partners had not yet settled and the room was restless with the Monday lunchtime tension born of expectant patients and inadequate resources.

“I'm your new dementia facilitator,” she said. “I'm developing some new guidelines for you.” She paused dramatically. “And a toolkit.” I imagined some sort of adjustable wrench that would fix dementia. “And the audit?” one of my partners asked. “Is coming later,” our facilitator assured us earnestly. …
Lithium and Thyroid Function in Manic-Depressive Psychosis
Authors: RONALD R. FIEVE, STANLEY PLATMAN
Journal: American Journal of Psychiatry (1968)

The authors report a possible long-termn side effect of lithium treatment in cases of manic-depressive disease. They examined 19 manic-depressive patients who had been on long-term lithium carbonate therapy and found that six had goiters and four others had evidence of thyroid pathology. Related studies and findings are reported, and possible mechanisms underlying the high incidence of thyroid pathology are discussed.
Targeted deletion of 5′HS1 and 5′HS4 of the β-globin locus control region reveals additive activity of the DNaseI hypersensitive sites
Authors: M. A. Bender, Julia N. Roach, Jessica Halow, Jennie Close, Raouf Alami, Eric E. Bouhassira, Mark Groudine, Steven N. Fiering
Journal: Blood (2001)
165 MELD, PROTEIN MALNUTRITION AND PREVIOUS INFECTIONS ARE PREDICTORS OF BACTERIAL INFECTIONS AND SEPSIS IN CIRRHOTIC PATIENTS
Authors: V. Giannelli, C. Lucidi, M. Giusto, A. Ruffa, O. Riggio, L. Ridola, M. Venditti, A.F. Attili, M. Merli
Journal: Journal of Hepatology (2010)
Academic Medical Centers' Conflict of Interest Policies
Authors: David J. Rothman, Susan Chimonas
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Treatment of Epilepsy
Authors: R. Kale
Journal: BMJ (1996)

Ed Simon Shorvon, Fritz Dreifuss, David Fish, David Thomas Blackwell Science, £99.50, pp 835 ISBN 0 6320 3782 2

”The biggest problem, however, is that the gulf between what is now possible and what is actually practised, even in advanced Western economies, and especially the developing countries, is enormous,” says E H Reynolds in the foreword to The Treatment of Epilepsy. This multiauthor textbook documents what is now possible. Whether it will reduce significantly the gulf that Reynolds mentions is doubtful. According to the World Bank's …
Department of Ethnology and Archeology, Pan-American Exposition.
Authors: A. L. Benedict
Journal: JAMA (1900)

Buffalo, N. Y., July 3, 1900. <h3>To the Editor:</h3> —The Pan-American Exposition has seen fit to entrust the care of the Department of Ethnology and Archeology to a practicing physician. I should be very glad if you would allow me to reach your readers with the following request for assistance: Many members of the medical profession are interested in the study of American Ethnology and Archeology, and not a few have valuable collections of Indian relics and skeletons from Indian graves. Those not directly interested in this study are so circumstanced as to be aware of the hobbies of their neighbors and could doubtless furnish the address of collectors. I should be greatly obliged for information and for the loan of collections for the use of this department of the Exposition. Exhibits which represent study in some special line of American Ethnology and Archeology will be particularly suitable.
Interface between adaptive and neoplastic growth in the pancreas.
Authors: D S Longnecker
Journal: Gut (1987)

The adaptive changes of hypertrophy and hyperplasia are diffuse and reversible responses of the pancreas to growth promoting stimuli. Early stages of neoplastic growth in the pancreas have been studied in carcinogen treated animals and preneoplastic lesions including atypical acinar cell foci and nodules, tubular ductal complexes and intraductal hyperplasia were identified. Neoplastic growth is clonal rather than diffuse and involves multiple steps through preneoplastic stages to produce a tumour. The individual steps are commonly regarded as reflecting a series of changes in the genome of the cells. Although the changes are likely to be irreversible, completion of the sequence usually requires a major portion of the lifespan of the host. The rate of progression of preneoplastic lesions to cancer may be modulated by the same factors that control adaptive growth. It follows that such factors will influence the probability that a carcinoma will develop. Cholecystokinin (CCK) seems to provide one example of a hormone/growth factor that can stimulate normal, adaptive, and neoplastic growth, and it is to be expected that other such hormones will be identified.
Are HIV positive asylum seekers an unfair burden on the NHS?
Authors: D. R Chadwick
Journal: BMJ (2003)

The extra burden on the NHS is one of the issues cited in the controversy over the number of asylum seekers entering the United Kingdom. My specialty, which includes care of patients infected with HIV, has seen a considerable increase in the number of new diagnoses of HIV in patients who acquired the virus abroad, such that most new cases in the United Kingdom are now in this category. A major proportion of these patients are asylum seekers, largely from sub-Saharan Africa.

Doctors treating asylum seekers are often required to support applications for exceptional leave to remain in this country, on the grounds that antiretroviral treatment is not widely available (or affordable) in their countries of origin. The growing realisation among doctors and politicians that a sizeable and increasing amount of resources is being taken up in the care of these patients has led to …
Abstract LB-86: Metabolic presentation of bladder cancer in urine
Authors: Jonathan McDunn, Regis Perichon, Steve Goodison, Charles J. Rosser
Journal: Cancer Research (2012)

Abstract Introduction and Objective Recently it has been shown that many oncogenes regulate metabolism, revitalizing interest in Warburg's observation of aerobic glycolysis by tumors. We and others have demonstrated the utility of metabolic signatures for the diagnosis of cancer in minimally invasive clinical samples and the differential diagnosis of cancer by stage and grade using biopsy samples. Here we apply state of the art metabolomic analysis to the diagnosis of bladder cancer from urine samples. Methods A case controlled study of ten transitional cell carcinoma (TCC) patients and matched non-TCC controls was performed. Briefly, clarified urine was extracted into aqueous methanol and characterized using three analytical platforms (gas chromatography mass spectrometry (MS) and ultrahigh performance liquid chromatography tandem MS). Spectral data were compared against an in-house library of over 2500 authentic standards and the relative abundance of each compound within the data set was calculated. Two-group statistics (R) and multivariate analysis (Array Studio, OmicSoft) were performed to identify differentially abundant metabolites. Results Three hundred and sixty-seven compounds were identified in this study and polypharmacy did not compromise the quality of the signal obtained for endogenous metabolites. Thirteen compounds, arising from diverse metabolic pathways, including: energetics, oxidative stress and amino acid catabolism, exhibited statistically significant differences between TCC and non-TCC cases. Principal component (PC) analysis demonstrated that the majority of the information in these metabolites (PC 1) separated TCC from non-TCC cases. Conclusions These data indicate the feasibility of a novel, non-invasive, urine-based diagnostic test to detect the presence of bladder tumors. Such a test could be positioned for use in conjunction with the current standard of care to improve patient management. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr LB-86. doi:1538-7445.AM2012-LB-86
GP accused of being involved in female genital mutilation fails to have charges thrown out
Authors: C. Dyer
Journal: BMJ (2014)

A GP caught in a newspaper sting over female genital mutilation has failed in a bid to have General Medical Council charges against him thrown out on the ground of entrapment.

Ali Mao-Aweys faces an allegation that he offered to help arrange for the procedure to be done on a child or children in the United Kingdom, in meetings and a telephone conversation with an …
THE HISTOLOGIGAL LESIONS OF ACUTE GLANDERS IN MAN AND OF EXPERIMENTAL GLANDERS IN THE GUINEA-PIG
Authors: James Homer Wright
Journal: The Journal of Experimental Medicine (1896)

The glanders nodule in the class of cases studied by us is in no sense analogous to the miliary tubercle in its histogenesis, and our studies afford no support to Baumgarten's views. The primary effect of the bacillus of glanders on a tissue we found to be not a production of epithelioid cells, which undergo necrosis and invasion by leucocytes, as happens in the cases in which the bacillus of tuberculosis is concerned, but to be the production of primary necrosis of the tissue, followed by inflammatory exudation, often of a suppurative character. Degenerative changes rapidly ensue in the inflammatory products. These conclusions are in harmony with the observations of Tedeschi, above referred to.
Bacterial Vaginosis-Reply
Authors: Jay Swedberg
Journal: JAMA (1986)

<h3>In Reply.—</h3> In response to comments by Drs Mengel and Pennachio, our study has a clinical focus—comparing two medication regimens (a single 2-g vs seven-day course of metronidazole) in the treatment of women who presented with symptoms associated with bacterial vaginosis. The patients were predominantly young white women receiving medical care at a community-based family practice residency clinic. The randomly assigned treatment groups were similar in terms of race, age, and parity. Risk factors for bacterial vaginosis were not evaluated. Selection based on risk factors would have invalidated the randomization and added additional assumptions to the interpretation of results. Furthermore, risk factors only provide various degrees of predictability for the occurrence of disease in a population—all the subjects in our study had the disease and were symptomatic. The study by Amsel et al<sup>1</sup>identified only two risk factors (use of intrauterine devices and history of previous<i>Trichomonas vaginalis</i>infection) that