tbuckley/cabot-search huggingface dataset:
Regulation of Vascular Inflammation and Remodeling by ETS Factors
Authors: Peter Oettgen
Journal: Circulation Research (2006)

The ETS (E26 Transformation-specific Sequence) factors are comprised of a family of transcription factors that share a highly conserved DNA binding domain. Although originally described for their role as protooncogenes in the development of several types of human cancer, they have subsequently been shown to regulate a wide variety of biological processes including cellular growth and differentiation under normal and pathological conditions. As transcription factors, they can either function as activators or repressors of gene expression. Several ETS family members are expressed in cells of vascular origin, including endothelial cells and vascular smooth muscle cells, where they regulate the expression of a number of vascular-specific genes. In the past few years, emerging evidence supports a novel role for selected ETS family members in the regulation of vascular inflammation and remodeling. ETS factor expression can be induced by proinflammatory cytokines, growth factors, and vasoactive peptides. Examples of some of the target genes regulated by ETS factors include adhesion molecules, chemokines, and matrix metalloproteinases. Targeted disruption of selected ETS family members such as Ets-1 in mice is associated with marked reductions in the recruitment of inflammatory cells and vascular remodeling in response to systemic administration of the vasoactive peptide angiotensin II. The purpose of this review is to provide an overview of recent advances that have been made in defining a role for selected members of the ETS transcription factor family in the regulation of vascular-specific gene expression, vascular inflammation, and remodeling.
Safety and efficacy of a novel plastic stent coated with stone-dissolving agents for the treatment of biliary stones in a porcine model
Authors: Xiao Cai, Wei Zhang, Ru Zhang, Xiao Dong Yuan, Qin Yang, Xiao Qi, Bai Li, Yue qin Qian, Xing Wang, Lun Lu, Zheng Xu, Xin Wan
Journal: Endoscopy (2014)

<b>Background and study aim: </b>We previously reported on a plastic stent that was coated with ethylenediaminetetraacetic acid (EDTA) and sodium cholate, which dissolved common bile duct (CBD) stones ex vivo. The aim of this study was to investigate the safety and efficacy of such stents on biliary stones in a live porcine model. <b>Methods: </b>Stents without coating or with degradable membranes containing 0 % or 50 % EDTA and sodium cholate were inserted together with human CBD stones into the porcine CBD. Serum laboratory variables, histological examinations of the bile duct, and the weight change in stones were compared during and after stent placement for 6 months. <b>Results:</b> A total of 16 pigs were included (5 no coating, 5 0 % coating, 6 50 % coating). Biliary stones showed decreased weight in all groups; however, stones in the group with 50 % coated stents showed a greater reduction in weight compared with the no coating and the 0 % coating groups (269 ± 66 mg vs. 179 ± 51 mg [<i>P</i> = 0.09]; 269 ± 66 mg vs. 156 ± 26 mg [<i>P</i> = 0.01], respectively). <b>Conclusions: </b>The plastic stent coated with 50 % agent enhanced CBD stone dissolution in vivo and may be a promising tool for patients with difficult biliary stones.
Coregulation of calcium channels and beta-adrenergic receptors in cultured chick embryo ventricular cells.
Authors: J D Marsh
Journal: Journal of Clinical Investigation (1989)

To examine mechanisms whereby the abundance of functional Ca channels may be regulated in excitable tissue, Ca channel number was estimated by binding of the dihydropyridine (DHP) antagonist 3H (+)PN200-110 to monolayers of intact myocytes from chick embryo ventricle. Beta adrenergic receptor properties were studied in cultured myocytes using [3H]CGP12177, an antagonist ligand. Physiological correlates for alterations in DHP binding site number included 45Ca uptake and contractile response to (+)BAYk 8644, a specific L-type Ca channel activator. All binding and physiological determinations were performed in similar intact cell preparations under identical conditions. 4-h exposure to 1 microM isoproterenol reduced cell surface beta-adrenergic receptor number from 44 +/- 3 to 17 +/- 2 fmol/mg (P less than 0.05); DHP binding sites declined in number from 113 +/- 25 to 73 +/- 30 fmol/mg (P less than 0.03). When protein kinase A was activated by a non-receptor-dependent mechanism, DHP binding declined similarly to 68% of control. Exposure to diltiazem, a Ca channel antagonist, for 18-24 h had no effect on number of DHP binding sites. After 4-h isoproterenol exposure, 45Ca uptake stimulated by BAYk 8644 declined from 3.3 +/- 0.2 nmol/mg to 2.9 +/- 0.3 nmol/mg (P less than 0.01) and BAYk 8644-stimulated increase in amplitude of contraction declined from 168 +/- 7 to 134 +/- 11% (P = 0.02). Thus, elevation of [cAMP] in myocytes is associated with a time-dependent decline in Ca channel abundance as estimated by DHP binding and a decline in physiological responses that are in part dependent on abundance of Ca channels. Binding of a directly acting Ca channel antagonist for 18-24 h does not modulate the number of DHP binding sites.
ROUTINE PERCUTANEOUS CORONARY INTERVENTION VERSUS MEDICAL THERAPY IN CLINICAL PRACTICE: THE ISACS-TC REGISTRY
Authors: Edina Cenko, Beatrice Ricci, Olivia Manfrini, Maria Dorobantu, Zorana Vasiljevic, Božidarka Knežević, Davor Miličić, Sashko Kedev, Dijana Trninic, Mirza Dilic, Olivija Gustienė, Irfan Daullxhiu, Akos Koller, Lina Badimon, Raffaele Bugiardini
Journal: Journal of the American College of Cardiology (2014)
Suprapatellar pouch rupture or extension into the thigh tissue in rheumatoid disease.
Authors: D Schapira, M Nahir
Journal: Annals of the Rheumatic Diseases (1986)

Virtually every study of survival among patients with rheumatoid arthritis indicates that mortality is increased,' 6 and some studies have found that cardio- vascular disease is a major contributor to the decreased survival.7 8 Since there has not been adequate attention paid to the possible link between corticosteroids and atherosclerosis, most mortality studies in rheumatoid arthritis provide insufficient data on corticosteroid use, or the subject is ignored entirely.In a mortality study by Prior et al at least half of the patients had taken corticosteroids for treatment of their disease, but information on dosage and duration of therapy was incomplete.7There have been no comprehensive pathological studies evaluating the long term effects of corticosteroids on the cardiovascular system.Nevertheless, since corticosteroids may induce or exacerbate known coronary risk factors, the prudent course is to avoid prolonged corticosteroid use whenever possible.Any benefit corticosteroids might offer in modifying the course of rheumatoid arthritis may be far outweighed by the potential for accelerating atherosclerotic disease, especially when therapy is initiated in younger individuals.
Heart Disease in Drivers of Public Motor Vehicles as a Cause of Highway Accidents
Authors: Robert L. Levy
Journal: JAMA (1963)

ON MARCH 4, 1963, a bus belonging to the Department of Hospitals of New York City suddenly left the road on Welfare Island and crashed into the East River. In addition to the driver, the vehicle carried ten persons employed by the Department. Of these, six, including the driver, died immediately by drowning, one succumbed one-half hour after the accident, and four survived. One body has not been recovered. This report was prepared at the request of the Commissioner of Hospitals of the City of New York. The medical history of the driver was obtained in part from the Department of Hospitals and in part from the office of the Chief Medical Examiner. The results of the autopsy have been furnished by Dr. Milton Helpern, Chief Medical Examiner of the City of New York. The driver was hired by the Department of Hospitals on March 16, 1953, as a
THE RELATION OF NEUTRAL FAT TO LACTESCENCE OF SERUM 1
Authors: Margaret J. Albrink, Evelyn B. Man, John P. Peters
Journal: Journal of Clinical Investigation (1955)

It has long been recognized that the cloudy or lactescent serum occurring in certain diseases contains an abnormally large amount of neutral fat (1), though a quantitative relationship between neutral fat and lactescence has not been established. In the present investigation the ultracentrifuge has been utilized to study the suspended lipid particles which are responsible for such lactescence. By analyzing a variety of clear and lactescent sera having high concentrations of one or more lipid components the relationship of neutral fat to lactescence has been verified and quantitatively defined. METHODS Serum lipids were determined before and after the removal of the suspended lipid particles by flotation in the ultracentrifuge. The technique of Van Eck, Peters, and Man (2) was modified as described below to permit
UK guidelines aim to improve pain management in children
Authors: Z. Kmietowicz
Journal: BMJ (1999)

Nurses and pain specialists in the United Kingdom have developed guidelines to improve the management of acute pain in children. The clinical guidelines are the result of a collaboration between the Royal College of Nursing and the charity Action for Sick Children and have taken on board the views of parents, anaesthetists, nurses, and children.

The guidelines emphasise the need to assess children's pain regularly by asking them how they feel and using pain assessment tools appropriate for …
EXPERIMENTAL NEPHRITIS IN RATS INDUCED BY INJECTION OF ANTI-KIDNEY SERUM
Authors: Joseph E. Smadel
Journal: The Journal of Experimental Medicine (1936)

Nephritis can be induced in rats by the injection of anti-kidney sera obtained from rabbits immunized with suspensions of perfused rat kidney. Anti-kidney sera, thus prepared, contain a number of antibodies capable, on injection into rats, of inducing a severe anaphylactoid reaction with general vascular manifestations that involve the kidney as well as other organs. These sera also contain a nephrotoxic agent that affects the kidney primarily. The nephrotoxic effect is characterized clinically by severe persistent albuminuria with casts, and transient anasarca during the acute disease, but no significant hematuria occurs. When a severe anaphylactoid reaction is superimposed on the nephrotoxic injury, hematuria is an outstanding feature. Nephrotoxin is demonstrable in vivo and is not related quantitatively to the precipitins in the anti-kidney serum against kidney extract. It is most readily obtained by immunization with kidney suspensions, but may occasionally appear after injections of other organ preparations; it does not result from immunization with erythrocytes or serum. Nephrotoxin is present in the globulin fraction of anti-kidney serum. The nephrotoxic action of anti-kidney serum is easily removed by absorption with kidney cells or fat-free kidney tissue. Similar preparations of liver likewise remove it, but less readily. Neither kidney, liver, or brain lipids affect it, nor does absorption with red blood cells or serum. Nephrotoxin appears to be an antibody that is relatively organ specific in its affinities. It differs from the more common antibodies involved in reverse anaphylaxis in one respect, at least: The animal rapidly becomes desensitized against the latter and fails to react, whereas desensitization to nephrotoxin is difficult to secure.
Lithium for Down Syndrome
Authors: Tracy Hampton
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Automated image-based tracking and its application in ecology
Authors: Anthony I. Dell, John A. Bender, Kristin Branson, Iain D. Couzin, Gonzalo G. de Polavieja, Lucas P.J.J. Noldus, Alfonso Pérez-Escudero, Pietro Perona, Andrew D. Straw, Martin Wikelski, Ulrich Brose
Journal: Trends in Ecology & Evolution (2014)
A new potential nano-oncological therapy based on polyamino acid nanocapsules
Authors: Teresa Gonzalo, Giovanna Lollo, Marcos Garcia-Fuentes, Dolores Torres, Juan Correa, Ricardo Riguera, Eduardo Fernandez-Megia, Pilar Calvo, Pablo Avilés, Maria José Guillén, Maria José Alonso
Journal: Journal of Controlled Release (2013)
Inadequacy of Perivascular Edema Hypothesis to Account for Distribution of Pulmonary Blood Flow in Lung Edema
Authors: BLAIR C. RITCHIE, GERTRAUD SCHAUBERGER, NORMAN C. STAUB
Journal: Circulation Research (1969)

West and co-workers obtained inversion of pulmonary blood flow per unit lung volume (Q · /V) in isolated, perfused dog lungs under special pressure-flow conditions in acute edema with high venous pressure. Repeating their experiments, we determined Q · /V by the 133 xenon scanning procedure and weighed the lungs continuously to determine the rate of edema formation. Edema slowly developed spontaneously in six lungs in which pulmonary artery pressure exceeded alveolar pressure, which exceeded venous pressure (zone II). We found no Q · /V changes. In six other zone II lungs we induced edema rapidly with alloxan. We found no changes in Q · /V. In six lungs with high venous pressure in which both pulmonary arterial and venous pressures exceeded alveolar pressure (zone III), we obtained flow inversion when driving pressure was less than 3 mm Hg and blood flow less than 100 ml/min. This confirms West's findings but shows that flow inversion is not related to pulmonary edema in general. We rapidly froze two additional lungs in each set. All showed interstitial perivascular edema, particularly below the hilum. Alveolar walls were more congested and blood vessels more distended at all levels in lungs with high venous pressure than in the other types. We found no vascular compression, kinking, or nipping in lungs showing Q · /V inversion. The perivascular spaces of lungs with spontaneous and alloxan-induced edema were distended with fluid, although flow distribution remained normal. We conclude that closure of dependent lung vessels by the accumulation of interstitial perivascular edema is not an adequate explanation for this phenomenon.
Encyclopedia of Neuroscience
Authors: Donna Bergen
Journal: JAMA (1988)

Notice the subject of this book: not "neurosciences" but "neuroscience." During the past 20 years, rapidly accelerating advances in neurochemistry, neurophysiology, neurobiology, neuropharmacology, neuroanatomy, etc, have brought about an exciting convergence of knowledge and techniques, which leaves the narrow specialist ever more isolated and ineffective. The scientist in neuronal membrane physiology, for example, must integrate knowledge of physics, immunology, anatomy, chemistry, molecular biology, and more, all the while keeping an eye out for possible clinical implications of his or her work. In addition, the nervous system can no longer be viewed as a relatively separate entity, functioning independently of other physiological systems. Hence we have the development of neuroimmunology, neurogenetics, and neuroendocrinology as growing fields of inquiry. The 1305+ pages of Dr George Adelman's<i>Encyclopedia of Neuroscience</i>are thus encyclopedic in scope but not in depth, since fine-honed reviews of all of these fields of knowledge would require many volumes.
Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant
Authors: Torkel Vang, Mauro Congia, Maria Doloretta Macis, Lucia Musumeci, Valeria Orrú, Patrizia Zavattari, Konstantina Nika, Lutz Tautz, Kjetil Taskén, Francesco Cucca, Tomas Mustelin, Nunzio Bottini
Journal: Nature Genetics (2005)
Origins of Concepts in Human Behavior: Social and Cultural Factors
Authors: Marjorie C. Meehan
Journal: JAMA (1977)

In 11 essays, Altschule discusses a variety of psychiatric historical topics. He reports at length on seventh century Isidore of Sentle's description of depression and on George Cheyne's 18th century report of the "English Malady," which is also depression. He tells of the Huron Indians' ideas about dreams and the unconscious, which strangely foreshadow Freud's. Acupuncture in 19th century America, the case history of James Tilly Matthews, and the pneuma concept of the soul are among other topics treated. The entire work shows evidence of much scholarly research and includes lengthy quotations from little-known sources. It is well written, with delightful touches of wit. Not all historians or psychiatrists will agree with Altschule's interpretations, especially since he seems to use his historical material as a basis for expressing his prejudices against psychoanalysis and most other aspects of contemporary psychiatric practice.
What is intradiscal therapy, anyway?
Authors: Phil Gunby
Journal: JAMA (1983)

The patient has clear-cut lumbar disk protrusion. His lower back and leg pain is unremitting. He cannot carry out his everyday activities, and four weeks of bed rest, analgesics, and physiotherapy have not helped. This patient, among the estimated 1% of adult Americans who will have a herniated disk at some time in their lives, could be considered for intradiscal therapy with chymopapain. However, emphasize the American Association of Neurological Surgeons (AANS) and the American Academy of Orthopaedic Surgeons (AAOS), joint sponsors of a number of one-day courses in the procedure: "Ideal candidates for chymopapain injection are also the ideal candidates for surgery." If chymopapain chemonucleolysis is chosen, it is performed either in the operating room or in a radiology department's special-procedures room equipped for sterile surgical techniques. The anesthetized patient (either local or general anesthesia is used) usually is taped to the special operating table on the left side,
Sodium glucose cotransporter 1 ligand BLF501 as a novel tool for management of gastrointestinal mucositis
Authors: Diego Cardani, Claudia Sardi, Barbara La Ferla, Giuseppe D’Orazio, Michele Sommariva, Fabrizio Marcucci, Daniela Olivero, Elda Tagliabue, Hermann Koepsell, Francesco Nicotra, Andrea Balsari, Cristiano Rumio
Journal: Molecular Cancer (2014)

Abstract Background Recent studies demonstrated that engagement of sodium glucose transporter 1 (SGLT-1) by orally administered D-glucose protects the intestinal mucosa from lipopolysaccharide (LPS)-induced injury. We tested whether SGLT-1 engagement might protect the intestinal mucosa from doxorubicin (DXR)- and 5-fluorouracil (5-FU)-induced injury in animal models mimicking acute or chronic mucositis. Methods Mice were treated intraperitoneally with DXR, alone or in combination with 5-FU, and orally with BLF501, a glucose-derived synthetic compound with high affinity for SGLT-1. Intestinal mucosal epithelium integrity was assessed by histological analysis, cellular proliferation assays, real-time PCR gene expression assays and Western blot assays. Student’s t-test (paired two-tailed) and χ 2 analyses were used for comparisons between groups. Differences were considered significant at p &lt; 0.05. Results BLF501 administration in mice treated with DXR and/or 5-FU decreased the injuries to the mucosa in terms of epithelial integrity and cellular proliferative ability. Co-treatment with BLF501 led to a normal expression and distribution of both zonula occludens-1 (ZO-1) and beta-catenin, which were underexpressed after treatment with either chemotherapeutic agent alone. BLF501 administration also restored normal expression of caspase-3 and ezrin/radixin/moesin (ERM), which were overexpressed after treatment with DXR and 5-FU. In SGLT1-/- mice, BLF501 had no detectable effects. BLF501 administration in wild-type mice with growing A431 tumors did not modify antitumor activity of DXR. Conclusions BLF501-induced protection of the intestinal mucosa is a promising novel therapeutic approach to reducing the severity of chemotherapy-induced mucositis.
Serum Antithrombin Content in Pregnancy
Authors: J. C. W. MacFarlane, A. P. Norman
Journal: BMJ (1954)

MEDITALS URNAL5 matrix, which is flexible enough to allow the fibrils to show their elasticity due to changes in orientation.The experiments undertaken show that with advancing age, beginning at the end of the third decade, there are changes in the collagen structure of both nucleus pulposus and annulus fibrosus which affect both factors.The nucleus loses its gel properties, as seen by the in- creased orientation and crystallization of the collagen with advancing age, whilst the collagen of annulus fibrosus under- goes similar changes, the fibrils being laid down in a uniaxial arrangement which inhibits its elastic mechanism.In these circumstances the intervertebral disk loses its normal physiological function, with secondary effects upon its asso, ciated spinal joints, particularly impaired mobility. SunmnaryThe collagenous changes in the human intervertebral disks with age have been studied, using x-ray crystallo- graphic methods.The x-ray diffraction diagrams so obtained prove that the elasticity of the annulus fibrosus is dependent upon the orientation and mobility of the collagen fibrils, properties which decrease with advancing age after the third decade.The x-ray diffraction diagrams of the nucleus pulposus show that increased orientation and ultimate crystallization of the collagen occurs with advancing age, indicat- ing loss of gel structure and hence impaired elasticity.The combination of these factors will explain the reduced elasticity of the intervertebral disk with age.
e-Cigarettes Match Nicotine Patches in Smoking Quit Rates
Authors: Anita Slomski
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The potential role of plasma neurohormones in the follow-up of unoperated or physiologically repaired congenitally corrected transposition of the great arteries
Authors: Ali Dodge-Khatami, Igor I. Tulevski, Gerd B. Bennink, J.F. Hitchcock, B.A. de Mol, Ernst E. van der Wall, Barbara JM. Mulder
Journal: Journal of the American College of Cardiology (2002)