tbuckley/cabot-search huggingface dataset:
Separation of Specific Antibody-Forming Mouse Cells by their Adherence to Insolubilized Endogenous Hormones
Authors: Kenneth L. Melmon, Yacob Weinstein, G. M. Shearer, Henry R. Bourne, Sara Bauminger
Journal: Journal of Clinical Investigation (1974)

Spleen cells from mice immunized with sheep red cells were separated by differential adherence to insolubilized histamine, catecholamines, and prostaglandins. The hormones were insolubilized by linking them to Sepharose beads through a protein carrier. We measured hemolytic plaque formation (per million splenic leukocytes) of cells which passed through columns of hormone-carrier-Sepharose beads (i.e., those cells that failed to bind). As compared with control (no column) cells, the number of plaque-forming cells was substantially reduced by passage through histamine, epinephrine, isoproterenol, and prostaglandin-E2 columns. Plaque-forming cells were not significantly reduced by passage through carrier Sepharose (another control) or norepinephrine- and prostaglandin-F2α-carrier Sepharose columns. Thus, the ability of an insolubilized hormone preparation to subtract plaque-forming cells roughly correlated with the presence of pharmacologic receptors for the corresponding free hormones, as judged by stimulation of cyclic AMP accumulation in the same cells, reported previously. Both 19S and 7S plaque-forming cells were subtracted by columns prepared from pharmacologically active hormones, but none of the insolubilized hormones stimulated accumulation of intracellular cyclic AMP. The cell membrane phenomenon that allows adherence to a given hormone-carrier-bead column may be identical with the cell receptor.
CHOLECYSTOGRAPHY: A REPORT OF FIFTY-THREE CASES CONTROLLED BY OPERATION
Authors: D. P. D. Wilkie, C. F. W. Illingworth
Journal: BMJ (1925)

CUIOLECYBTOGRAPHY.r MEzDILTJSR rectus may be held taut, and if this is so on the right side it is easy to mistake the condition for appendicitis.
Hysteresis of the RT Interval With Exercise
Authors: Andrew D. Krahn, George J. Klein, Raymond Yee
Journal: Circulation (1997)

The diagnosis of the long-QT syndrome (LQTS) may be difficult to establish in patients with normal or borderline prolongation of the QT interval. Noninvasive markers are needed to identify patients with LQTS.Fourteen patients with known LQTS, 9 unaffected family members, and 40 control subjects underwent modified Bruce protocol exercise testing. The RT interval (peak of R wave to peak of T wave) and rate-corrected RT interval (RTc) were measured during exercise and recovery. The RT interval at 1 minute into recovery was subtracted from the RT interval at a similar heart rate during exercise (deltaRT). The RTc shortened by 61 milliseconds (ms) in the LQTS patients compared with 23 to 26 ms in the other two groups (P=.003 by ANOVA). The RT interval shortened in a linear fashion in all patients but demonstrated persistent shortening during recovery in the LQTS patients. This was manifested as a hysteresis loop in the curve relating the RT interval to cycle length. The hysteresis loop was present in 13 of 14 LQTS patients and only 4 of 40 control subjects. DeltaRT >25 ms had a sensitivity of 73%, a specificity of 92%, a positive predictive value of 79%, and a negative predictive value of 90% for LQTS.Hysteresis of the RT interval with exercise may be useful for the diagnosis of LQTS.
Pseudohypertension Due to Diffuse Vascular Calcification in Chronic Renal Failure
Authors: LARRY J. JACOBS
Journal: Annals of Internal Medicine (1979)

Brief Reports1 March 1979Pseudohypertension Due to Diffuse Vascular Calcification in Chronic Renal FailureLARRY J. JACOBS, M.D., HOWARD MANTEN, M.D., ROBERT J. MYERBURG, M.D., DAVID S. SHEPS, M.D.LARRY J. JACOBS, M.D.Search for more papers by this author, HOWARD MANTEN, M.D.Search for more papers by this author, ROBERT J. MYERBURG, M.D.Search for more papers by this author, DAVID S. SHEPS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-3-353 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMetastatic soft-tissue calcification is a well-known complication of chronic renal failure. We describe pseudohypertension (that is, cuff systolic blood pressure higher than 300 mm Hg without intravascular hypertension) due to diffuse arterial calcification occurring in a patient with chronic renal failure.A 63-year-old Hispanic man was admitted to the Jackson Memorial Hospital coronary care unit complaining of chest pain. His history was remarkable for chronic renal failure of 4½ years' duration, for which he required hemodialysis three times weekly. He reported that for the past several months his blood pressure had been "unobtainable" at the dialysis center. Communication with the...References1. TAGUCHISUWANGOOL JP: "Pipe stem" brachial arteries. A cause of pseudohypertension. JAMA 228:733, 1974 CrossrefMedlineGoogle Scholar2. PARFITT A: Soft tissue calcification in uremia. Arch Intern Med 124:544-556, 1969 CrossrefMedlineGoogle Scholar3. FRIEDMANNOVACKTHOMSON SSG: Arterial calcification and gangrene in uremia. N Engl J Med 280:1392-1394, 1969 CrossrefMedlineGoogle Scholar4. ROSENFRIEDMANRAIZNERGERSTMANN HSAK: Azotemic arteriopathy. Am Heart J 84:250-255, 1972 CrossrefMedlineGoogle Scholar5. GIPSTEINCOBURNADAMSLEEPARSASELLERSSUKIMASSRY RJDDKAWS: Calciphylaxis in man. A syndrome of tissue necrosis and vascular calcification in 11 patients with chronic renal failure. Arch Intern Med 136:1273-1280, 1976 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Miami School of Medicine Miami, Florida PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPrevalence and clinical characteristics of pseudohypertension in elderly patients prepared for coronary artery angiographyOsler's maneuver: Absence of usefulness for the detection of pseudohypertension in an elderly populationPseudohypertension masquerading as malignant hypertensionBone Disease in Chronic Renal FailureBlood Pressure Measurement in Older Patients With Hypertension 1 March 1979Volume 90, Issue 3Page: 353-354KeywordsArterial calcificationBlood pressureCardiac care unitHispanic peopleHypertensionIschemiaMedical dialysisRenal failureSystolic pressure Issue Published: 1 March 1979 PDF downloadLoading ...
Criteria for Hospitalizing Children Who Have Ingested Products Containing Hydrocarbons
Authors: Nick Anas, Vanthaya Namasonthi, Charles M. Ginsburg
Journal: JAMA (1981)

The clinical records of 950 children who ingested products containing hydrocarbons were reviewed. Eight hundred children were asymptomatic at the time of the initial evaluation and remained so during a six-to eight-hour period of observation. All had normal chest films, and all were treated as outpatients. One hundred fifty other children were admitted to the hospital; 79 were symptomatic at the time of initial medical evaluation and had abnormal chest roentgenograms. Seventy-one other children were asymptomatic but had roentgenographic evidence of pulmonary involvement (36) or had had pulmonary symptoms before arriving at the medical facility (35). Complications (seven) occurred only in symptomatic children who had roentgenographic evidence of pneumonia. These data suggest that the majority of children who are brought for medical evaluation after ingesting hydrocarbon-containing substances do not experience pulmonary complications and therefore do not require hospitalization. Only children who are symptomatic at the time of initial medical evaluation or who became symptomatic during a six- to eight-hour observation period require hospitalization.
Gallbladder Visualization at Twenty-four Hours With Octreotide Scintigraphy Potential False-Positive Finding
Authors: MICHAEL S. KIPPER, LINDA D. KROHN
Journal: Clinical Nuclear Medicine (1997)

Somatostatin receptor scintigraphy with In-111 octreotide has shown excellent accuracy in many neuroendocrine tumors, including carcinoid. Substantial gallbladder activity may be present on early images; however, the administration of a fatty meal and/or the effect of time generally results in little or no image interference by 24 hours. The authors present a patient with metastatic carcinoid whose 4-hour image showed no gallbladder activity but whose 24-hour image showed intense gallbladder concentration. This normal variation must be kept in mind, especially when evaluating the liver for metastatic deposits. Misinterpretation may dramatically affect subsequent patient management.
Eosinophilic fasciitis and eosinophilic cellulitis in a patient with abnormal circulating clonal T cells: increased production of interleukin 5 and inhibition by interferon alfa
Authors: Lars E. French, Michael Shapiro, Jacqueline M. Junkins-Hopkins, Jonathan T. Wolfe, Alain H. Rook
Journal: Journal of the American Academy of Dermatology (2003)
Transurethral Electrovaporization of the Prostate vs. Transurethral Resection
Authors: M. Gallucci, P. Puppo, M. Perachino, P. Fortunato, G. Muto, G. Breda, A. Mandressi, G. Comeri, C. Boccafoschi, F. Francesca, S. Guazzieri, G.L. Pappagallo
Journal: European Urology (1998)
Computer-Assisted Design of Studies Using Routine Clinical Data
Authors: ROBERT L. BLUM
Journal: Annals of Internal Medicine (1986)

To facilitate the analysis of routine, longitudinal, clinical data, we developed a computer program called the RX Study Module. Our prototype uses a small online knowledge base of medicine and biostatistics to help create and execute a detailed statistical study design. The program identifies possible confounding variables, selects methods for controlling them, creates a statistical model, determines patient eligibility criteria, and retrieves data from records. We used the program to examine the hypothesis that daily prednisone administration elevates serum cholesterol. Data from 49 patients with chronic rheumatologic disorders were analyzed from a database of 1787 patients. A regression model was fitted to each patient's record. Changes in cholesterol were significantly correlated (p = 10-5) with changes in prednisone after a lag of at least 1 week and after recorded confounders were controlled: ▵cholesterol = 18. 4 loge(prednisone). Routinely collected patient data may become an important resource for generating and studying new medical hypotheses.
Problems of Antenatal Care in the Tropics
Authors: V. J. Hartfield
Journal: BMJ (1967)

the villages there was no significant change in the incidence of scabies.About a year ago we stopped using benzyl benzoate and started using monosulfiram soap, advising the patients to allow the soap to dry on the skin.In this way an effective concentration of monosulfiram is built up on the skin and in the clothes and bedding.The results have been quite remarkable, and scabies has almost disappeared in some villages.The only obstacle to complete eradication seems to be the cost of the soap at 2s. each in a country where a manual worker earns only 6s. a day when he can find work.I was surprised to see no mention of mono- sulfiram in the copies of the B.M.7.which have reached me so far.-Iam, etc.,
Risk Factors for Senility
Authors: Albert A. Fisk
Journal: JAMA (1985)

This book might have been better entitled "Risk Factors for Old Age" or "for Senescence" than "for Senility." Of the 17 chapters, only four specifically concern themselves with senility, the common term used for chronic dementia. Since the book looks at risk factors for the whole aging process, rather than for just those concerned with dementia, it covers a broad field. Unfortunately, each subject is covered in a somewhat brief fashion. The first four chapters deal with standard gerontological topics, such as a biology and the pathophysiology of aging. The chapter "Risk Factors for Senile Dementia," which best fits the title of the book, is limited to eight pages. The genetic studies on Alzheimer's disease, including studies on histocompatibility and Down's syndrome, are compressed into a one-page summary. A detailed and critical presentation and evaluation of the literature available in this area would have been useful. Conversely, the chapter on
Treatment of Diabetic Diarrhea with Clonidine
Authors: RICHARD N. FEDORAK
Journal: Annals of Internal Medicine (1985)

Stimulation of alpha 2-adrenergic receptors on enterocytes promotes fluid and electrolyte absorption and inhibits anion secretion. Loss of adrenergic innervation may play a role in impaired intestinal fluid and electrolyte absorption in diabetic patients with autonomic neuropathy. Clonidine, an alpha 2-adrenergic agonist, was used to treat three patients with "idiopathic" diabetic diarrhea after other treatments had failed: The volume of diarrhea declined significantly (p less than 0.01). Diarrhea recurred when the drug was withdrawn, but the patient's condition improved again when clonidine treatment was reintroduced. Hypotension did not occur as a side effect presumably because of the autonomic neuropathy of these patients.
Pediatric Duodenal Perforation Demonstrated by Hepatobiliary Imaging
Authors: ATUL MAINI, CHETAN PATEL, SANDEEP AGARWALA, ARBINDER KUMAR, BHARATHI DASAN
Journal: Clinical Nuclear Medicine (2000)

The diagnosis of intestinal perforation in children is difficult. Computed tomography has been a useful investigative modality. A case of duodenal perforation is presented in which radionuclide hepatobiliary imaging was useful.
Genetic variations in HLA-B region and hypersensitivity reactions to abacavir
Authors: Seth Hetherington, Arlene R Hughes, Michael Mosteller, Denise Shortino, Katherine L Baker, William Spreen, Eric Lai, Kirstie Davies, Abigail Handley, David J Dow, Mary E Fling, Michael Stocum, Clive Bowman, Linda M Thurmond, Allen D Roses
Journal: The Lancet (2002)
AIDS: The Burdens of History
Authors: Gert H. Brieger
Journal: JAMA (1989)

It is now a rare issue of this or any comparable medical journal that does not include an article about some aspect of the acquired immunodeficiency syndrome. The AIDS literature seems to be growing even faster than the epidemic itself. Even so, as history is being made, the historians have but just begun to pay serious attention to these remarkable events of the 1980s. Attempts to compare our present plight with past epidemics provide some intellectual challenge, if few sound guides, for policy-making. It is to such questions, as to the need to preserve the historical record itself, that we must now address ourselves. Dr Elizabeth Fee of The Johns Hopkins School of Public Health and Dr Daniel Fox of The Medical School at Stony Brook have compiled a series of a dozen essays that range widely over important historical parallels as well as philosophic and policy issues raised by
Laboratory costs and the NHS reforms
Authors: C Kelleher, P J Roderick, T W Meade
Journal: BMJ (1991)

increased in diabetic subjects."9Non-insulin dependent diabetics have an increased risk of cardiovascular disease'0 even when a correction is made for recognised cardiovascular risk factors."An excess cardiovascular risk may also be associated with impaired glucose tolerance.'2The prevalence of non-insulin dependent diabetes and impaired glucose tolerance may vary between populations but a combined prevalence of over 60% is reported for a Scandinavian population of men aged between 65-84.'3A similar prevalence of glucose intolerance in the study population would undoubtedly result in an increased number of deaths from cardiovascular and non-cardio- vascular causes.An underestimate of diabetes as a cause of death in this population may be available from the Swedish mortality register.The observation of the relation of serum sialic acid and mortality is of undoubted interest but warrants further detailed investigation before serum sialic acid concentration is accorded the status of a risk factor or predictor of mortality.
The Social Contract and the Treatment of Permanent Kidney Failure
Authors: Richard A. Rettig
Journal: JAMA (1996)

MEDICARE, enacted in 1965 to provide health insurance for the elderly, was extended in 1972 to the disabled under 65 years of age. The disability provision, in turn, became the basis for Medicare coverage of those with end-stage renal disease (ESRD)—regardless of age—who were "deemed to be disabled." Eligibility for this entitlement requires that an individual be diagnosed as having ESRD and be fully or currently insured under Social Security, or be the spouse or dependent child of an insured individual. An estimated 92% to 93% of the US population is thus covered for ESRD treatment. Congress justified this near-universal, disease-specific entitlement partly in the expectation that it would adopt some form of national health insurance in 1973 or 1974.<sup>1</sup> Friedman finds Medicare's ESRD a "splendid model" of health care.<sup>2</sup>His view of the matter as an international horse race in which "we're No. 1" raises some interesting
Keeper of the Gate
Authors: Jerome J. Hoffman
Journal: JAMA (1990)

I must confess that I have, at times, fantasized about how confused my old mentors at the Beth Israel Medical Center in New York City would be were they to be resurrected and come face-to-face with the complexities of today's technology. The endless monitors, scanners, imagers, and computers would very likely stun them. Long before that might happen, however, at their first entrance into the old building facing Stuyvesant Park East, the simplest of electrical call-boards and beepers, for good reason, would probably arouse more resentment than astonishment. They could boast of having enjoyed a much better arrangement. They had McCarthy. Tall, chronically flushed, and gray-haired, McCarthy (no one knew his first name), with his old-style stickpin, hornrimmed glasses, ruddy complexion, and dignified mien, resembled nothing so much as a downtown Tammany Hall politician. A protuberant abdomen bulged against the gunmetal buttons of his meticulously maintained whipcord uniform. He held
THE ETIOLOGY OF TRIFACIAL NEURALGIA OR TIC DOULOUREUX AND CLINICAL TREATMENT
Authors: NELSON T. SHIELDS
Journal: JAMA (1913)

The fundamental cause of trifacial neuralgia lies in some structural change. The really painful tic usually occurs about the period of middle life or later and is generally caused by a lesion or lesions within the teeth. All strain, whether mental or physical (and this comprises that common to all diseases and conditions), which a normal amount of sleep cannot relieve or during which the tissue consumed cannot be restored, these abnormal conditions are the foundations for an earlier degeneration of the nerve structure. No injury to the teeth from external causes, and no injury to the dental pulp from constitutional causes ever repairs itself. That is, should a tooth be broken or decayed it can never be restored by natural means, or should a pulp nodule or dentinal tumor form within the pulp from constitutional causes it will never be absorbed. A normal life should be led more on
Psychosomatic Specificity: Experimental Study and Results
Authors: Martin Grotjahn
Journal: JAMA (1969)

Franz Alexander, the founder and first director of the Institute for Psychoanalysis in Chicago, started the Specificity Project in the year 1951, and was the team leader until 1956. Then he left and was followed by Thomas French, and later by George Pollock, who now, three years after the termination of the project, reports about its design, progress, and quantitative findings. As a presentation of this often-discussed and controversial project, the present volume is the first one to be published. It will be followed by further details about the case study by teams of experts in different medical specialties. The diseases studied are bronchial asthma, rheumatoid arthritis, ulcerative colitis, essential hypertension, neurodermatitis, thyrotoxicosis, duodenal peptic ulcer. Statistical analysis seems to indicate that one can indeed differentiate between certain specific diseases, "purely" on the basis of the psychological patterns associated with each one of them.
Medicine and the Universities
Authors: David R. Goddard
Journal: JAMA (1965)

The theme of this communication is that of the reciprocal relationship of medicine and the universities. The association between the two is an old one which can be traced to the universities of Italy and Paris in the 12th century. The medieval universities had several faculties; the conventional four were law, philosophy, theology, and medicine. However, medical schools per se gradually appeared and probably had their origin from the 17th-century schools of Holland and Scotland; as you have heard from Dr. Corner, the University of Pennsylvania's school had its origin in Edinburgh. By and large, medicine has flowered in the great universities, for they have furnished the environment, the protection, the administration, and, frequently, the funds for its development. In turn, the medical faculties have stimulated the universities and often raised their intellectual levels and standards. Although the proprietary schools that developed during the 19th century in the United States
Accelerated Mammary Tumor Onset in a HER2/ <i>Neu</i> Mouse Model Exposed to DDT Metabolites Locally Delivered to the Mammary Gland
Authors: Nakpangi A Johnson, Arline Ho, J. Mark Cline, Claude L Hughes, Warren G Foster, Vicki L Davis
Journal: Environmental Health Perspectives (2012)

Background: The association of DDT (dichlorodiphenyltrichloroethane) with breast cancer is controversial, but animal studies directly linking DDT to risk are lacking. Concerns with DDT reside in its environmental persistence, bioaccumulation in breast adipose tissue, and endocrine-disrupting actions. Whereas most attention has been focused on estrogenic congeners, we tested the cancer-inducing potential of the antiandrogen, p,p´-DDE [1,1-dichloro-2,2-bis(p-chlorophenyl) ethylene], the most prevalent and persistent DDT metabolite.Objectives: We aimed to determine whether developmental exposure to p,p´-DDE stored in adipose tissue surrounding the cancer-prone mammary epithelium of MMTV-Neu mice influences tumor development.Methods: For localized delivery, Elvax 40P pellets containing p,p´-DDE were implanted into the mammary fat pads of prepubertal female mice. We compared mammary tumor development with p,p´-DDE with development in response to its estrogenic isomer, o,p´-DDE [1,1-dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl) ethylene], and a mixture of both isomers.Results: p,p´-DDE implants significantly accelerated mammary tumor onset compared with vehicle Elvax implants. o,p´-DDE had similar results, but only at ≤ 10 months of age. Lipid-adjusted levels of p,p´-DDE in mammary adipose tissue and serum in young mice were within the ranges of human exposure, whereas concentrations in aged mice were low to undetectable. Exposure to a 2:1 ratio of p,p´-DDE:o,p´-DDE did not result in the younger latency observed with the individual isomers.Conclusions: p,p´-DDE exposure at concentrations relevant to human exposure accelerates mammary carcinogenesis in mice, possibly through hormonal and/or other actions. These data suggest that DDE exposure would promote, but not cause, mammary tumorigenesis. Developmental exposure in immature mammary tissue continues to affect tumor onset even after p,p´-DDE levels have declined. Future studies are needed to determine whether early exposure to p,p´-DDE correspondingly predisposes women to early-onset breast cancer.
Cytokines (interferon-γ and tumor necrosis factor–α)-induced nuclear factor–κB activation and chemokine (C-X-C motif) ligand 10 release in Graves disease and ophthalmopathy are modulated by pioglitazone
Authors: Alessandro Antonelli, Silvia Martina Ferrari, Poupak Fallahi, Simona Piaggi, Aldo Paolicchi, Stefano Sellari Franceschini, Mario Salvi, Ele Ferrannini
Journal: Metabolism (2010)