tbuckley/cabot-search huggingface dataset:
Dose Sparing with Intradermal Injection of Influenza Vaccine
Authors: Richard T. Kenney, Sarah A. Frech, Larry R. Muenz, Christina P. Villar, Gregory M. Glenn
Journal: New England Journal of Medicine (2004)

The loss of half the U.S. supply of influenza vaccine due to contamination has created a critical shortage. Dose-sparing strategies that use intradermal delivery of vaccines may be one approach to consider.We conducted a randomized, open-label trial outside the influenza season in 100 healthy adults 18 to 40 years of age to compare the immunogenicity and safety of intradermal immunization with influenza vaccine with standard intramuscular immunization. Subjects were randomly assigned to receive either a single intramuscular dose of 0.5 ml of trivalent influenza vaccine, containing at least 15 microg of hemagglutinin per strain, by means of a prefilled syringe or a single intradermal dose of 0.1 ml, containing at least 3 microg of hemagglutinin per strain, by means of a fine-gauge needle; both injections were in the deltoid region. Changes in the hemagglutination-inhibition (HAI) antibody titer were assessed by comparing geometric mean titers and fold increases relative to baseline values and by comparing changes in the seroconversion and seroprotection rates. Local and systemic adverse events were assessed after both types of vaccination.Subjects who received an intradermal injection with one fifth the standard dose of influenza vaccine had increases in the geometric mean HAI titer by a factor of 15.2 for the H1N1 strain in the vaccine, 19.0 for the H3N2 strain, and 12.4 for the B strain on day 21, as compared with respective increases by a factor of 14.9, 7.1, and 15.3 for the intramuscular injection of the standard dose. Seroconversion and seroprotection rates were similar in the two groups on day 21, ranging from 66 to 82 percent and 84 to 100 percent, respectively. Local reactions were significantly more frequent among recipients of intradermal injections than among recipients of intramuscular injections, but such reactions were mild and transient.In this study of young adults, intradermal administration of one fifth the standard intramuscular dose of an influenza vaccine elicited immunogenicity that was similar to or better than that elicited by intramuscular injection. Intradermal administration could be used to expand the supplies of influenza vaccine, but further studies are needed before this strategy can be recommended for routine use.
L-Arginine deficiency and supplementation in experimental acute renal failure and in human kidney transplantation
Authors: Lothar Schramm, Mylinh La, Ekkehart Heidbreder, Markus Hecker, Joe S. Beckman, Kai Lopau, Josef Zimmermann, Johann Rendl, Christoph Reiners, Sabine Winderl, Christoph Wanner, Harald H.H.W. Schmidt
Journal: Kidney International (2002)
Abstract 3541: Combination of the ruthenium compound KP1339 with the tyrosine kinase inhibitor sorafenib: A promising approach for the treatment of human hepatoma
Authors: Petra Heffeter, Bihter Atil, Kushtrim Kryeziu, Ute Jungwirth, Elisabeth Gal, Bernhard K. Keppler, Walter Berger
Journal: Cancer Research (2011)

Abstract Aim of this study was to test the in vitro and in vivo activity of KP1339, a promising ruthenium-based anti-cancer compound, in combination with the tyrosine kinase inhibitor sorafenib against human hepatoma cells. As a first approach, the drugs were tested together against a hepatoma cell line panel (n=7) by MTT assay. Combination of KP1339 with sorafenib induced additive to synergistic effects in all cell lines tested. Especially at higher sorafenib concentrations (10 µM) strong synergism with CI values between 0.1 and 0.5 were observed. Notably, synergistic activity with KP1339 was found in sorafenib-resistant as well as sorafenib-responsive cell lines. Recently, we have presented that KP1339 treatment induced phosphorylation of P38, JNK and erk and led to cell cycle arrest in G2/M Phase. Consequently, the effects of sorafenib on KP1339-induced P38 phosphorylation were investigated. Western blot analyses revealed that sorafenib strongly reduced phosphorylation of P38 and erk after KP1339 treatment. Moreover, addition of sorafenib reduced KP1339-induced G2/M arrest. Finally, the activity of the KP1339/sorafenib combination was evaluated in xenograft experiments (Hep3B cells). KP1339 monotreatment led to a 2.4-fold increase in life span (mean survival 80 days vs. 33 days in control) and thus was superior to sorafenib monotherapy, which induced a 1.9-fold survival increase (60 days). Combination of KP1339 with sorafenib increased the mean survival by 3.9-fold to 96 days. Together, our data indicate that the combination of KP1339 with Sorafenib is very promising in vitro and in vivo especially against human hepatoma cells. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3541. doi:10.1158/1538-7445.AM2011-3541
Influence of adenosine on basal myocardial function: observations in anaesthetised, domestic swine
Authors: H. GEWIRTZ, A. SALVO, Y. SUN, A. S MOST
Journal: Cardiovascular Research (1984)

Data from experiments in isolated cardiac muscle preparations indicate that adenosine in high concentration (10(-3) mol X litre-1) exerts a negative inotropic effect on the myocardium under basal conditions. The following study was performed to test the hypothesis that adenosine exerts a similar negative inotropic effect when administered in an intact animal model in a dose sufficient to cause maximal coronary vasodilatation. Six open chest anaesthetised pigs were studied as follows. Ultrasonic length sensors were placed in the endocardium of the free wall of the left ventricle in a region perfused by the left anterior descending (LAD) coronary artery. Large increases in endocardial blood flow in response to adenosine administration, which could enhance segmental function ("garden hose effect"), were prevented by inserting an artificial stenosis (73% reduction in lumenal diameter) in the proximal third of the LAD. Measurements of haemodynamics, regional myocardial blood flow (microsphere technique), and regional systolic function were made at control 1, at the end of 10 min of intracoronary adenosine infusion (3.0 mumol X min-1) at a dose which exceeded that previously shown to cause maximal coronary vasodilatation and at second control 20 to 40 min after discontinuation of adenosine infusion.(ABSTRACT TRUNCATED AT 250 WORDS)
Upregulation Of Glucocorticoids Beta Receptors In Severe Rsv Bronchiolitis In Infants
Authors: P.V. Diaz, R. Mammani, R.A. Pinto, A.A. Gaggero, M.R. Bono, J. Guerrero, A. Goecke
Journal: Journal of Allergy and Clinical Immunology (2012)
Antibodies to Silicone Detected In Patients With Severe Inflammatory Reactions
Authors: Teri Randall
Journal: JAMA (1992)

SOME PATIENTS may be capable of mounting specific immune responses to silicone, new research suggests. Researchers have detected increased levels of antibodies specific to silicone in the sera of two patients. Both had severe, chronic inflammatory reactions around implanted Silastic ventriculoperitoneal shunt tubing. Neither had infections that otherwise might have explained the inflammation (<i>Lancet</i>. 1992; 340:510-513). Historically, silicone materials have been generally thought to be immunologically inert. The August 29<i>Lancet</i>article is "the first published study to demonstrate specific immune reactants capable of recognizing silicone material," says first author Randall Goldblum, MD, professor of pediatrics, and human biological chemistry and genetics at the University of Texas Medical Branch at Galveston. The other authors are Galveston researchers Ronald Pelley, MD, Alice O'Donell, MD, Debra Pyron, and John Heggers, PhD. Goldblum and his colleagues detected the antibodies with a modified enzymelinked immunosorbent assay (ELISA), in which Silastic tubing serves as the
20 IN VITRO ACTIVITY AND PHARMACOLOGIC PROPERTIES OF TWO NOVEL SERIES OF HCV PROTEASE INHIBITORS
Authors: D.N. Standring, C. Parsy, F.-R. Alexandre, M. Derock, F. Leroy, T. Convard, M. La Colla, L. Lallos, A.-G. Loi, C. Musiu, T. Marceddu, B. Poddesu, L. Vargiu, M. Liuzzi, D. Surleraux
Journal: Journal of Hepatology (2008)
Lymphographic Alterations of Pelvic Lymphatics After Radiotherapy
Authors: Hervy E. Averette
Journal: JAMA (1963)

LYMPHOGRAPHY is the radiographic visualization of lymph vessels and nodes after intralympathic injection of a radiopaque substance. One application of lymphography is in the preoperative detection of lymphatic involvement by metastatic tumor. During the past 2½ years lymphography has been employed in the study of 109 patients with gynecologic cancer on the Obstetrics-Gynecology Service at the University of Miami School of Medicine. Twenty-seven patients were studied after undergoing radiotherapy for pelvic cancer. It soon became evident that irradiation of pelvic lymphatics could produce lymphographic findings that might be confused with metastasis to the lymphatic system. Examples of lymphographic alterations secondary to radiotherapy are presented in this report.  Technique  Lymphography is best performed when the patient is lying supine on a fluoroscopy table with the feet fixed in an extended position by adhesive tape. Lymphatic vessels are localized for cannulation on the dorsal aspects of the feet by injecting 1
OTA Report Disputes Success of Unconventional Cancer Therapies
Authors: L. Fintor
Journal: JNCI Journal of the National Cancer Institute (1990)

Journal Article OTA Report Disputes Success of Unconventional Cancer Therapies Get access Lou Fintor Lou Fintor Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 82, Issue 21, 7 November 1990, Pages 1668–1669, https://doi.org/10.1093/jnci/82.21.1668 Published: 07 November 1990
Anti-HIV efficacy and biodistribution of nucleoside reverse transcriptase inhibitors delivered as squalenoylated prodrug nanoassemblies
Authors: Hervé Hillaireau, Nathalie Dereuddre-Bosquet, Rym Skanji, Fawzia Bekkara-Aounallah, Joachim Caron, Sinda Lepêtre, Sébastien Argote, Laurent Bauduin, Rahima Yousfi, Christine Rogez-Kreuz, Didier Desmaële, Bernard Rousseau, Ruxandra Gref, Karine Andrieux, Pascal Clayette, Patrick Couvreur
Journal: Biomaterials (2013)
THE RETENTION OF S35-LABELLED BOVINE SERUM ALBUMIN IN NORMAL AND IMMUNIZED RABBIT LIVER TISSUE
Authors: Justine S. Garvey, Dan H. Campbell
Journal: The Journal of Experimental Medicine (1957)

The S(35)-label of S(35)-BSA was detected in the liver tissue of rabbits to the extent of 0.02 per cent (10 microg or approximately 10(14) molecules) of the injected material at 140 days after injection. The rate of loss of antigen at the termination of the experiment was of such an order that significant amounts would be expected to persist for at least several years. Data are reported which extend the retention data previously reported on S(35)-labelled hemocyanin. They indicate that amounts of the order of 0.05 per cent (25 microg.) of antigen material persist at 330 days after injection. All of the radioactivity of material retained in the liver tissue 6 weeks after injection was immunologically related to the original S(35)-BSA antigen. Preliminary studies are reported which indicate that the retained antigen is bound to ribonucleic acid. A new method is described for the isolation of p-azophenylsulfonate bovine serum albumin from tissue extracts by means of a Dowex 2 adsorbent.
A Comparison of Right Versus Left Hepatic Duct Endoprosthesis Insertion in Malignant Hilar Biliary Obstruction
Authors: A. A. Polydorou, E. M. Chisholm, A. A. Romanos, J. F. Dowsett, P. B. Cotton, A. R. W. Hatfield, R. C. G. Russell
Journal: Endoscopy (1989)

Endoscopic endoprosthesis insertion plays an increasingly important role in the palliation of jaundice in patients with unresectable malignant hilar biliary obstruction (HBO). Drainage of both obstructed lobes in Types II and III HBO is not necessary to achieve adequate palliation, providing 25 % of the liver volume is drained by a single endoprosthesis. The anatomy of the main hepatic ducts suggests some benefit may accrue from preferential drainage of the left hepatic duct. We have reviewed a consecutive series of 151 patients with Type II and III HBO over a 4-year period to compare the outcome of endoprosthesis placement in either the right (RHD) or left (LHD) hepatic duct, to test this hypothesis.
Sequence variants of the gene encoding chemotractant receptor expressed on Th2 cells (CRTH2) is associated with asthma in an African American (AA) population
Authors: S.K. Huang, R.A. Mathias, E. Ehrlich, B. Plunkett, A. Togias, K.C. Barnes, F. Malveaux, T.H. Beaty
Journal: Journal of Allergy and Clinical Immunology (2003)
Triiodothyronine. Physiological and clinical significance
Authors: H. Gharib
Journal: JAMA (1974)

Triiodothyronine (T<sub>3</sub>) is normally present in human serum, two thirds being a secretory product of thyroid gland and the remaining one third being derived from extrathyroid conversion of thyroxine to T<sub>3</sub>. Serum T<sub>3</sub>determination has become an important factor in the investigation of thyroid physiology and is now available to the clinician in the diagnosis and management of various thyroid disorders. In general, thyrotropinstimulating hormone or thyroxine levels are better diagnostic indexes of hypothyroidism, while T<sub>3</sub>determination is a useful index of thyroid hyperfunction.
CARDIOVASCULAR EFFECTS OF ONE YEAR OF ALAGEBRIUM AND ENDURANCE EXERCISE TRAINING IN HEALTHY OLDER INDIVIDUALS
Authors: Naoki Fujimoto, Jeffrey L. Hastings, Graeme Carrick-Ranson, Keri M. Shafer, Shigeki Shibata, Paul S. Bhella, Shuaib M. Abdullah, Kyler W. Barkley, Kara N. Boyd, Sheryl A. Livingston, Dean Palmer, Benjamin D. Levine
Journal: Journal of the American College of Cardiology (2013)
Role of membrane potential in Ba2+ induced automatieity in guinea pig cardiac myocytes
Authors: F. Valenzuela, M. Vassalle
Journal: Cardiovascular Research (1991)

Journal Article Role of membrane potential in Ba2+ induced automatieity in guinea pig cardiac myocytes Get access Fermin Valenzuela, Fermin Valenzuela Search for other works by this author on: Oxford Academic PubMed Google Scholar Mario Vassalle Mario Vassalle Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 25, Issue 5, May 1991, Pages 421–430, https://doi.org/10.1093/cvr/25.5.421 Published: 01 May 1991 Article history Received: 03 July 1990 Accepted: 17 December 1990 Published: 01 May 1991
The Continuing Epidemics of Obesity and Diabetes in the United States
Authors: Ali H. Mokdad
Journal: JAMA (2001)

Recent reports show that obesity and diabetes have increased in the United States in the past decade.To estimate the prevalence of obesity, diabetes, and use of weight control strategies among US adults in 2000.The Behavioral Risk Factor Surveillance System, a random-digit telephone survey conducted in all states in 2000, with 184 450 adults aged 18 years or older.Body mass index (BMI), calculated from self-reported weight and height; self-reported diabetes; prevalence of weight loss or maintenance attempts; and weight control strategies used.In 2000, the prevalence of obesity (BMI >/=30 kg/m(2)) was 19.8%, the prevalence of diabetes was 7.3%, and the prevalence of both combined was 2.9%. Mississippi had the highest rates of obesity (24.3%) and of diabetes (8.8%); Colorado had the lowest rate of obesity (13.8%); and Alaska had the lowest rate of diabetes (4.4%). Twenty-seven percent of US adults did not engage in any physical activity, and another 28.2% were not regularly active. Only 24.4% of US adults consumed fruits and vegetables 5 or more times daily. Among obese participants who had had a routine checkup during the past year, 42.8% had been advised by a health care professional to lose weight. Among participants trying to lose or maintain weight, 17.5% were following recommendations to eat fewer calories and increase physical activity to more than 150 min/wk.The prevalence of obesity and diabetes continues to increase among US adults. Interventions are needed to improve physical activity and diet in communities nationwide.
Transureteral Phonocatheter Recording of the Renal Arterial Pulse
Authors: HERBERT L. TANENBAUM, WILLIAM S. KISER
Journal: Circulation (1964)

The renal artery and iliac artery pulses were recorded indirectly during split renal function studies in hypertensive patients suspected of having renal vascular lesions. A phonocatheter was easily passed up each ureter and the pulses were recorded at the level of the crossing of the iliac artery and again in the renal pelvis. In patients with renal vascular occlusion, there was a distinct diminution in the amplitude of the transmitted renal arterial pulse as compared to the unoccluded side. The recording of vascular bruits from each side was helpful in localizing their origin. Selected cases confirmed at surgery were presented.
1147-211 Determinants of muscular damage with external cardioversion of atrial fibrillation: Results of a randomized trial comparing biphasic with monophasic shock
Authors: Stefano Fumagalli, Lorenzo Boncinelli, Nadia Boni, Margherita Padeletti, Adriana Virgillo, Caterina Franceschini, Massimo Aglietti, Niccoló Marchionni
Journal: Journal of the American College of Cardiology (2004)
Later effects of grounding of tanker Braer on health in Shetland
Authors: D Campbell, D Cox, J Crum, K Foster, A Riley
Journal: BMJ (1994)

radiographic investigations did not benefit patients.Radiology staff enforced the guidelines that were issued to other staff in September 1992 and also rejected request cards on which the only information provided was "pre-op."The rate of requests for preoperative chest radiography fell from 24% to 7%, which represents an annual reduction of nearly 3500 examinations.We can monitor the rate of preoperative chest radiography easily, using computers both in the radiology department and in the operating theatres; we intend to keep the rate at or below 7%.We thank our radiography and clerical colleagues for their essential contribution.1 Royal College of Radiologists Working Party (1993).Making the best use of a department of clinical radiology: guidelines for doctors.2nd ed.
Allogeneic hematopoietic stem cell transplantation (allo SCT) for chronic myeloid leukemia in the imatinib era: evaluation of its impact within a subgroup of the randomized German CML Study IV
Authors: Susanne Saussele, Michael Lauseker, Alois Gratwohl, Dietrich W. Beelen, Donald Bunjes, Rainer Schwerdtfeger, Hans-Jochem Kolb, Anthony D. Ho, Christiane Falge, Ernst Holler, Günter Schlimok, Axel R. Zander, Renate Arnold, Lothar Kanz, Robert Dengler, Claudia Haferlach, Brigitte Schlegelberger, Markus Pfirrmann, Martin C. Müller, Susanne Schnittger, Armin Leitner, Nadine Pletsch, Andreas Hochhaus, Joerg Hasford, Rüdiger Hehlmann
Journal: Blood (2009)
Biology, blind men, and elephants
Authors: B. Y. Yankelowitz
Journal: BMJ (1978)

an imaginary balance sheet, between the hour in Slagthorpe and the week in Killarney or Vancouver, all expenses paid.And most people are terribly polite and kind, putting you up in their own houses, arranging dinner parties, or taking you to the local beauty spots.* * *Lest you think my stories paranoid exaggerations, however, let me end with the true account of Sir Gavin Walpole-Wilson, a very senior physician asked to speak to students on an MRCP course at a foremost medical establishment.Although he had been promised a parking space, the porter knew nothing about him and refused to allow his car into the hospital grounds; however, caution had led him to arrive half an hour early, most of which he spent finding a parking meter.Nobody met him outside the lecture theatre, which was in darkness when he entered; fortunately, as he was silhouetted against the light he was recognised by the lecturer, who was one of his former registrars."Ah, Sir Gavin," he called out, "come and sit here at the front."At the end of this lecture, Sir Gavin gave his; there was a lively discussion, which was ended by a cleaner saying that she needed the occupants out in order to clean up the room.By now it was 2 pm and no host had appeared.Sir Gavin made his way back to his car, and drove the 50 miles to his home, where his wife made him a cup of
Clinical Predictors of Severe Cerebral Amyloid Angiopathy and Influence of<i>APOE</i>Genotype in Persons With Pathologically Verified Alzheimer Disease
Authors: John M. Ringman, Michael C. Sachs, Yan Zhou, Sarah E. Monsell, Jeffrey L. Saver, Harry V. Vinters
Journal: JAMA Neurology (2014)

<h3>Importance</h3> Although cerebral amyloid angiopathy (CAA) has important clinical implications, our understanding of it and ability to diagnose it are limited. <h3>Objective</h3> To determine pathological correlates and clinical factors identifiable during life that predict the presence of severe CAA in persons with pathologically confirmed Alzheimer disease (AD). <h3>Design, Setting, and Participants</h3> We compared demographic and clinical variables at the earliest visit during life at which participants were found to have cognitive impairment and compared pathological variables between persons ultimately found to have no or severe CAA at autopsy using logistic regression. Analyses were repeated separately for carriers and noncarriers of the<i>APOE</i>ε4 allele. Data were obtained from the Uniform Data Set, which comprises longitudinal clinical assessments performed in the Alzheimer's Disease Centers funded by the National Institute on Aging. Participants included 193 persons with AD and severe CAA and 232 persons with AD and no CAA. All participants had cognitive impairment and met National Institute on Aging–Reagan Institute neuropathological criteria for AD. <h3>Main Outcomes and Measures</h3> Prevalence of demographic characteristics and the<i>APOE</i>ε4 allele and odds ratios (ORs) of clinical variables for the prediction of severe CAA. <h3>Results</h3> Persons with severe CAA compared with those without CAA were more likely to carry an<i>APOE</i>ε4 allele (64.9% vs 42.8%, respectively;<i>P</i> &lt; .001), to be Hispanic (6.8% vs 1.3%, respectively;<i>P</i> = .003), to have had a transient ischemic attack (12.5% vs 6.1%, respectively; OR = 2.1; 95% CI, 1.0-4.4), and to have lower degrees of diffuse amyloid plaque pathology (mean [SD] Consortium to Establish a Registry for Alzheimer's Disease score, 1.2 [0.5] vs 1.4 [0.8], respectively;<i>P</i> = .01). Those with CAA compared with those without CAA more commonly had intracerebral hemorrhage (9.3% vs 3.5%, respectively;<i>P</i> = .01), cortical microinfarcts (20.7% vs 12.9%, respectively;<i>P</i> = .03), and subcortical leukoencephalopathy (20.5% vs 12.1%, respectively;<i>P</i> = .02). Noncarriers of the<i>APOE</i>ε4 allele with severe CAA compared with those without CAA had a higher prevalence of stroke (11.1% vs 3.9%, respectively; OR = 3.8; 95% CI, 1.0-14.6) and hypercholesterolemia (50.0% vs 32.7%, respectively; OR = 2.3; 95% CI, 1.1-4.7). <h3>Conclusions and Relevance</h3> Being Hispanic and having had a transient ischemic attack–like episode were predictors of CAA in persons with AD. Less diffuse parenchymal amyloid pathology in persons with severe CAA suggests a difference in β-amyloid trafficking.