Ibuprofen and Meningoencephalitis
Authors: DAVID R. PERERA
Journal: Annals of Internal Medicine (1984)

Letters and Corrections1 April 1984Ibuprofen and MeningoencephalitisDAVID R. PERERA, M.D., A. KURT SEIFFERT, M.D., H. MCLEAN GREELEY, M.D.DAVID R. PERERA, M.D.Search for more papers by this author, A. KURT SEIFFERT, M.D.Search for more papers by this author, H. MCLEAN GREELEY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-100-4-619_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Meningitis or meningoencephalitis has been reported after the use of Ibuprofen in patients with systemic lupus erythematosus (1-3) or mixed connective tissue disease (4). Recently Von Reyn (5) reported the case of a patient without collagen vascular disease who developed aseptic meningitis after sulindac.A 72-year-old man with osteoarthritis was hospitalized three times over a 5-week period with meningoencephalitis. Four weeks before his first admission, he was started on Ibuprofen therapy, 400 mg four times a day. Two weeks later he developed muscle soreness and aching that progressed to nausea, vomiting, confusion, and combativeness. On examination he...References1. WASNER C. Ibuprofen, meningitis, and systemic lupus erythematosus. J Rheumatol. 1978;5:162-4. MedlineGoogle Scholar2. WIDENERLITTMAN HB. Ibuprofen induced meningitis in systemic lupus erythematosus. JAMA. 1978;239:1062-4. CrossrefMedlineGoogle Scholar3. SAMUELSONWILLIAMSON CH. Ibuprofen associated aseptic meningitis in systemic lupus erythematosus. West J Med. 1979;131:57-79. MedlineGoogle Scholar4. BERNSTEIN R. Ibuprofen-related meningitis in mixed connective tissue disease. Ann Intern Med. 1980;92:206-7. LinkGoogle Scholar5. VON REYN C. Recurrent aseptic meningitis due to sulindac. Ann Intern Med. 1983;99:343-5. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DAVID R. PERERA, M.D.; A. KURT SEIFFERT, M.D.; H. MCLEAN GREELEY, M.D.Affiliations: Group Health Cooperative of Puget Sound 200 16th Avenue East; Seattle, WA 98112 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCentral adverse drug reactions of NSAIDsCharacteristics of Meningitis Caused by IbuprofenDrug-induced aseptic meningitisRisks and Benefits of Nonsteroidal Anti-Inflammatory Drugs in ChildrenDrug-Induced Aseptic MeningitisDrug-induced meningitisPossible Optic Nerve Side Effeects Associated with Nonsteroidal Anti-Inflammatory DrugsDécouverte d'un lupus érythémateux disséminé à l'occasion d'une hépatite à l'ibuprofèneDrug- and Chemical-Induced Aseptic Meningitis: A Review of the LiteratureTrimethoprim-sulfamethoxazole-associated aseptic meningitis: Case reports and review of the literatureResident Article: Ibuprofen-Associated Meningitisin a Woman with Only Serologic Evidence of a Rheumatologic DisorderDrug-related recurrent meningitisRecurrent ibuprofen-induced aseptic meningitis: third episode after only 200 mg of generic ibuprofenAseptic Meningitis Associated with NaproxenASEPTIC MENINGITIS FROM OVER-THE-COUNTER IBUPROFENSevere systemic hypersensitivity reaction to ibuprofen occurring after prolonged therapyIbuprofen and Aseptic MeningitisDANIEL L. BOULAND, M.D., N. LENNARD SPECHT, M.D., DOUGLAS R. HEGSTAD, M.D.Adverse Drug ReactionsAnti-inflammatory analgesics and drugs used in rheumatoid arthritis and gout 1 April 1984Volume 100, Issue 4Page: 619-619KeywordsIbuprofenInterstitial lung diseasesLupus erythematosusMeningitisMeningoencephalitisMixed connective tissue diseaseMyalgiaNauseaOsteoarthritisVomiting ePublished: 1 December 2008 Issue Published: 1 April 1984 PDF downloadLoading ...