tbuckley/cabot-search huggingface dataset:
The Cure of Folly (Extraction of the Stone of Madness)
Authors: M. Therese Southgate
Journal: JAMA (2003)

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The action of metoclopramide on human gastroduodenal motility
Authors: A. G. Johnson
Journal: Gut (1971)

The action of metoclopramide on gastroduodenal motility was studied in 23 subjects: eight symptomless volunteers and 15 patients with varying upper abdominal conditions. The response depended on the basal contraction pattern before the drug was given, irrespective of the clinical diagnosis. The size of the antral contractions was consistently increased and the duodenal contractions became more closely linked to those of the antrum. This demonstrates a mechanism for the increased rate of gastric emptying that is observed clinically after metoclopramide.
Notes of a Case of Enterectomy for Gangrenous Intestine in which the Button of Murphy, of Chicago, was Successfully Employed
Authors: J. Murphy
Journal: BMJ (1895)

April 4th.Since the above was written the patient has gained strength and has left the hospital.He is very emaciated and the malignant growth is rapidly increasing, but he has no abdominal pain and no sickness, and takes ordinary food.The: button has probably dropped back into the disused portion of the intestine.
Assessment of the (14C) aminopyrine breath test in liver disease.
Authors: J Galizzi, R G Long, B H Billing, S Sherlock
Journal: Gut (1978)

Different methods of performing the (14C) aminopyrine breath test have been assessed. A tracer dose of 2 muCi without a loading dose and with a single breath collection at two hours was the method selected, since it gave the best discrimination between patients with hepatocellular diseases and normal subjects (5.2 +/- 0.2%, mean +/- SEM). Reduced values occurred in patients with chronic active hepatitis (with and without cirrhosis) (1.5 +/- 0.2%), alcoholic cirrhosis (1.7 +/- 0.4%) and hepatitis (2.5 +/- 0.3%), and late primary biliary cirrhosis suggesting defective microsomal function with respect to demethylation. Normal results were common in early primary biliary cirrhosis. Two weeks of prednisolone therapy caused some improvement in the breath test in nine of 10 patients with chronic active hepatitis. It is concluded that the (14C) aminopyrine breath test is a simple test for detecting hepatocellular dysfunction, but has no obvious diagnostic advantage over the determination of serum aspartate transaminase and two hour post-prandial bile-acids.
TOLERANCE TO NITROGLYCERIN.
Authors: D. D. STEWART
Journal: JAMA (1905)

In a recent issue ofThe Journal,<sup>1</sup>there appeared a note concerning the administration of nitroglycerin in which the correspondent (Dr. Maddox) referred to a case under treatment at my service in the Jefferson Medical College in 1888. This patient was an interesting example of rapidly-acquired tolerance to the drug, as he was taking, as remarked by Dr. Maddox, when seen by him in the clinic of Dr. Da Costa, 20 grains of pure nitroglycerin daily. It may be of interest to state that this and similar cases in which marked tolerance to nitroglycerin was easily acquired, I made the subject of several papers some years ago. I reported this particular case in the<i>Philadelphia Polyclinic</i>in August and in December, 1888, under the caption of "Remarkable Tolerance to Nitroglycerin." Later, in a paper entitled "Tolerance to Nitroglycerin Easily Acquired: Limitations of Use of the Drug in Chronic Nephritis,"2
UK juniors to be surveyed over action on pay
Authors: L. Beecham
Journal: BMJ (1999)

Representatives of the United Kingdom's 34000 junior hospital doctors have unanimously agreed to survey doctors to find out their views on taking industrial action because of the failure of the pay review body and the health departments to value out of hours work appropriately.

At a meeting of the BMA's Junior Doctors Committee last week angry members called for a new national agreement …
Specific correction of impaired acid hydrolase secretion in storage pool-deficient platelets by adenosine diphosphate.
Authors: B Lages, C A Dangelmaier, H Holmsen, H J Weiss
Journal: Journal of Clinical Investigation (1988)

Storage pool-deficient (SPD) platelets, which have decreased amounts of dense-granule and/or alpha-granule constituents, contain normal amounts of lysosomal acid hydrolases, but in some cases exhibit impaired secretion of these enzymes. We examined this impaired secretion response in SPD patients with varying extents of granule deficiencies, and determined the effects of added dense-granule constituents. Acid hydrolase secretion was impaired in patients with severe dense-granule deficiencies, but not in patients with lesser dense-granule deficiencies, including those with alpha-granule deficiencies as well. When dense-granule constituents (ADP, ATP, serotonin, Ca+2, pyrophosphate) were added to gel-filtered platelets, ADP, but none of the other constituents, completely corrected the impairment of thrombin and A23187-induced secretion in SPD platelets. The concentration of ADP required to normalize thrombin-induced secretion varied markedly, from 0.01 to 10 microM, among the individual patients. Fixation of platelets with formaldehyde before centrifugation did not prevent the enhancement of secretion by ADP. Excess ATP, which acts as a specific antagonist of ADP-mediated responses, completely blocked this enhancement of secretion in SPD platelets by ADP, and partially inhibited acid hydrolase secretion induced by low, but not high, concentrations of thrombin in normal platelets as well. Treatment of normal platelets with acetylsalicylic acid in vivo, but not in vitro, produced an impairment of acid hydrolase secretion similar in extent to that in SPD platelets, but which could not be completely corrected by added ADP. One possible explanation of these results is that the impairment of acid hydrolase secretion may be secondary to the dense-granule deficiency in SPD platelets, and that secreted ADP may potentiate the lysosomal secretion response in normal platelets as well.
Report of the Subcommittee of the Medical Charities Committee
Authors: T. Bridgwater
Journal: BMJ (1897)

DICAL ~~~~~~~~~~~~~~~~~~~~~JOURN can be little doubt that a measure of the kind would be heartily welcomed, and would meet with great support.Your Committee trusts that the session will not terminate before the introduction of the promised Bill.Such a Bill should include: i.The compulsory therapeutic detention of habitual drunkards, after a judicial process, on sworn medical testi- mony, and with every possible safeguarding of the liberty of the subject.2. The establishment and management of special homes for inebriates for the poorest, for criminal and non-criminal inebriate offenders.3. The inclusion of intoxication by any narcotic in the term "'habitual drunkenness."4. The appearance of voluntary applicants for curative detention before one justice instead of two justices as at present, or before some other authorised official.5. Magisterial discretion to award a term of curative restraint in a reformatory or hospital, instead of a term of imprisonment in a gaol.It would also be desirable to have all habitual drunkards under curative treatment subject to State or municipal inspection.The Committee is glad to learn that in Austria, while the authorities are considering the project of special legislation for inebriates, one clinic has been set apart specially for the treatment of habitual drunkards.
IMPACT OF ADDITIONAL KISSING BALLOON TECHNIQUE ON CLINICAL AND ANGIOGRAPHIC OUTCOME AFTER SINGLE DES IMPLANTATION FOR NON-LEFT MAIN BIFURCATION WITHOUT SIDE-BRANCH STENOSIS
Authors: Shinya Sasaki, Toshiya Muramatsu, Reiko Tsukahara, Yoshiaki Ito, Hiroshi Ishimori, Keisuke Hirano, Masatsugu Nakano, Masahiro Yamawaki, Motoharu Araki, Hideyuki Takimura, Yasunari Sakamoto, Ikki Komatsu, Takuro Takama
Journal: Journal of the American College of Cardiology (2011)
Intravenous Gammaglobulin in a Hypothyroid Patient with the Antiphospholipid Antibody Syndrome
Authors: Yasuko Nakamura
Journal: Annals of Internal Medicine (1993)

Letters15 May 1993Intravenous Gammaglobulin in a Hypothyroid Patient with the Antiphospholipid Antibody SyndromeYasuko Nakamura, MD, Yukiko Uchida, MD, and Masami Murakami, MDYasuko Nakamura, MDSearch for more papers by this author, Yukiko Uchida, MDSearch for more papers by this author, and Masami Murakami, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-10-199305150-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Many reports of thrombocytopenia associated with autoimmune thyroid disease have occurred since Jackson's first description [1]. Most were cases of autoimmune thyroid disease complicated by idiopathic thrombocytopenic purpura. We describe a hypothyroid patient with thrombocytopenia and a paradoxical thromboembolic episode, diagnosed as having an antiphospholipid antibody syndrome because of high serum levels of anticardiolipin antibodies and lupus anticoagulant.A 65-year-old Japanese woman was admitted to our hospital with a goiter and signs and symptoms of hypothyroidism. At 53 years of age, she had had a cerebral infarction. Laboratory data confirmed hypothyroidism as follows: The free-triiodothyronine value was ...References1. Jackson AS, Madison L. Acute hemorrhagic purpura associated with exophthalmic goiter. JAMA. 1931; 96:38-9. Google Scholar2. Parke A, Maier D, Wilson D, Andreoli J, Ballow M. Intravenous -globulin, antiphospholipid antibodies, and pregnancy. Ann Intern Med. 1989; 110:495-6. Google Scholar3. Antonelli A, Bombardieri S, Alberti B, Saracino A, De Vita S, Baschieri L. Variations of thyroid function and autoantibodies in patients with Hashimoto's thyroiditis treated with intravenous gammaglobulin. Presented at the International Hashimoto Symposium Eightieth Anniversary of Hashimoto Disease, 2-5 December 1992, Fukuoka, Japan. Google Scholar4. Marongiu F, Conti M, Martas ML, Sorano GG, Mameli G, Salis G, et al. Anticardiolipin antibodies in Grave's disease: relationship with thrombin activity in vivo. Thrombosis Research. 1991; 64:745-9. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByChapter 13 Endocrine Manifestations of the Antiphospholipid SyndromeChapter 17 Autoimmune Hypothyroidism and Hyperthyroidism in Systemic Autoimmune DiseaseThyroid Disease in Patients with Idiopathic Thrombocytopenia: A Cohort StudyAnticardiolipin antibody in vascular parkinsonismAntiphospholipid antibody syndrome 15 May 1993Volume 118, Issue 10Page: 827-828KeywordsAntibodiesAntibody therapyAutoantibodiesHypothyroidismPlateletsThyroidThyroid diseasesThyroid hormonesThyroid-stimulating hormoneThyroxine Issue Published: 15 May 1993 CopyrightCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
FOXP3–miR-146–NF-κB Axis and Therapy for Precancerous Lesions in Prostate
Authors: Runhua Liu, Bin Yi, Shi Wei, Wei-Hsiung Yang, Karen M. Hart, Priyanka Chauhan, Wei Zhang, Xicheng Mao, Xiuping Liu, Chang-Gong Liu, Lizhong Wang
Journal: Cancer Research (2015)

The tumor-suppressive activity of FOXP3 has been observed in tumor initiation, but the underlying mechanism still remains largely unknown. Here, we identified a FOXP3-microRNA-146 (miR-146)-NF-κB axis in vitro and in vivo in prostate cancer cells. We observed that FOXP3 dramatically induced the expression of miR-146a/b, which contributed to transcriptional inhibition of IRAK1 and TRAF6, in prostate cancer cell lines. Tissue-specific deletion of Foxp3 in mouse prostate caused a significant reduction of miR-146a and upregulation of NF-κB activation. In addition, prostatic intraepithelial neoplasia lesions were observed in miR-146a-mutant mice as well as in Foxp3-mutant mice. Notably, the NF-κB inhibitor bortezomib inhibited cell proliferation and induced apoptosis in prostate epithelial cells, attenuating prostatic intraepithelial neoplasia formation in Foxp3-mutant mice. Our data suggest that the FOXP3-miR-146-NF-κB axis has a functional role during tumor initiation in prostate cancer. Targeting the miR-146-NF-κB axis may provide a new therapeutic approach for prostate cancers with FOXP3 defects.
A Second Genetic Variant on Chromosome 15q24-25.1 Associates with Lung Cancer
Authors: Pengyuan Liu, Ping Yang, Xifeng Wu, Haris G. Vikis, Yan Lu, Yian Wang, Ann G. Schwartz, Susan M. Pinney, Mariza de Andrade, Adi Gazdar, Colette Gaba, Diptasri Mandal, Juwon Lee, Elena Kupert, Daniela Seminara, John Minna, Joan E. Bailey-Wilson, Margaret Spitz, Christopher I. Amos, Marshall W. Anderson, Ming You
Journal: Cancer Research (2010)

A common variant on chromosomal region 15q24-25.1, marked by rs1051730, was found to be associated with lung cancer risk. Here, we attempted to confirm the second variant on 15q24-25.1 in several large sporadic lung cancer populations and determined what percentage of additional risk for lung cancer is due to the genetic effect of the second variant. SNPs rs1051730 and rs481134 were genotyped in 2,818 lung cancer cases and 2,766 controls from four populations. Joint analysis of these two variants (rs1051730 and rs481134) on 15q24-25.1 identified three major haplotypes (G_T, A_C, and G_C) and provided stronger evidence for association of 15q24-25.1 with lung cancer (P = 9.72 x 10(-9)). These two variants represent three levels of risk associated with lung cancer. The most common haplotype G_T is neutral; the haplotype A_C is associated with increased risk for lung cancer with 5.0% higher frequency in cases than in controls [P = 1.68 x 10(-7); odds ratio (OR), 1.24; 95% confidence interval (95% CI), 1.14-1.35]; whereas the haplotype G_C is associated with reduced risk for lung cancer with 4.4% lower frequency in cases than in controls (P = 7.39 x 10(-7); OR, 0.80; 95% CI, 0.73-0.87). We further showed that these two genetic variants on 15q24-25.1 independently influence lung cancer risk (rs1051730: P = 4.42 x 10(-11); OR, 1.60; 95% CI, 1.46-1.74; rs481134: P = 7.01 x 10(-4); OR, 0.81; 95% CI, 0.72-0.92). The second variant on 15q24-25.1, marked by rs481134, explains an additional 13.2% of population attributable risk for lung cancer.
Questions of the Month for the Noninternist
Authors: FRANK COLE
Journal: Annals of Internal Medicine (1971)

Letters and Comments1 January 1971Questions of the Month for the NoninternistFRANK COLE, M.D.FRANK COLE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-74-1-148_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I answered the four Questions of the Month in the September 1970 issue of the ANNALS. I got them all right, four out of four.This shows that multiple choice questions are bad or that anesthesiologists are good. You see, I have my Boards, only they're in anesthesiology. Do I get them in medicine?I showed them to a lawyer and he got two out of four.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Lincoln, Nebr. 68502 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1971Volume 74, Issue 1Page: 148-148KeywordsAnesthesiology ePublished: 1 December 2008 Issue Published: 1 January 1971 PDF downloadLoading ...
Calcium antagonists in hypertension: relation to abnormal sodium transport.
Authors: A M Heagerty, R F Bing, H Thurston, J D Swales
Journal: BMJ (1983)

Leucocyte sodium efflux rate constants and intracellular electrolyte contents were estimated in 13 patients with untreated essential hypertension. There was no correlation between intracellular sodium or potassium content or efflux rate constant and blood pressure. The patients were then treated with oral nifedipine and blood pressure controlled. Sodium efflux rate constants and electrolyte contents were estimated one and three months after the start of treatment. There was a significant fall in blood pressure, but mean sodium efflux rate constant and intracellular sodium content were unchanged. There was no correlation between the fall in blood pressure, initial sodium efflux, or intracellular sodium content. These data do not support the hypothesis that the sodium pump and intracellular sodium content have a direct role in generating raised blood pressure, or that treatment of hypertension with calcium antagonists corrects a fundamental alteration of calcium-sodium exchange across the cell membrane.
Free radicals mediate endothelial dysfunction of coronary arterioles in diabetes
Authors: R Ammar
Journal: Cardiovascular Research (2000)

Previous studies have demonstrated that vascular responses to acetylcholine (ACh) are impaired in diabetes mellitus (DM).Since reactive oxygen species (ROS) generation is increased in various disease states including DM, and a direct reaction between nitric oxide (NO) and superoxide anion has been demonstrated, we tested the hypothesis that inhibition of ROS will restore coronary microvascular responses to ACh in a dog model of DM (alloxan 60 mg/kg, i.v., 1 week prior to study).Changes in coronary microvascular diameters in diabetic (blood glucose >200 mg%) and normal animals to ACh (1-100 microM, topically) in the presence and absence of superoxide dismutase and catalase were measured using intravital microscopy coupled to stroboscopic epi-illumination and jet ventilation.In diabetic animals in the absence of ROS scavengers, ACh induced coronary microvascular dilation was impaired when compared to normal animals (ACh 100 microM: DM=25+/-5%; normal=64+/-13%, P<0.05). Topical application of SOD (250 U/ml) and catalase (250 U/ml) restored to normal ACh induced coronary microvascular responses in DM while having no affect in normal animals. Responses to adenosine and nitroprusside were not different between normal and diabetic groups.These data provide direct evidence that oxygen-derived free radicals contribute to impaired endothelium-dependent coronary arteriolar dilation in diabetic dogs in vivo.
D'Aix en Savoye a Aixilia: pour les curieux et curistes d'Aix-les-Bains
Authors: F. Bach
Journal: Annals of the Rheumatic Diseases (1973)

doyens of French Rheumatology, played an active part.In this small book Dr. Frangon presents reminiscences of his own, and of his father and grand- father, all of whom practised with conspicuous success at Aix-les-Bains, and who are now succeeded in tum by Dr. Fran9on's son Jean.Dr. Francon describes vividly some of the many personalities who have visited Aix-les-Bains and have taken 'the cure', among them Balzac, Lamartine, Maupaussant, Verlaine, Queen Victoria, and Dom Pedron, the Emperor of Brazil.Dr. Frangon paints a convincing and charming picture of these celebrities and of their annual sojourn at Aix-les- Bains.He points out that these were the private patients of the past, the predecessors of those sent by the Securite Sociale-the French National Health Service.Today 90 per cent. of those who are treated at Aix are paid for by the State.He discusses the benefit they received from their treatment and briefly notes that taking the waters is sans risques iatrogenes, suggesting that 'the cure' at Aix may well be less dangerous than swallowing some of the pills that we are accustomed to prescribe for our rheumatic patients.
The Primary-Care Practitioner — Specialist or Jack-of-All-Trades
Authors: Peter Draper, Helen L. Smits
Journal: New England Journal of Medicine (1975)

Abstract Primary-care physicians, too often viewed as low-level generalists, are more appropriately thought of as specialists whose work demands specific skills. These physicians function as managers, advocates, educators, and counselors for their patients while also serving as co-ordinators of other professionals involved in primary care. The basis for education in primary care should be a recognition of the specialized nature of the work that primary-care physicians perform. Faculty members in primary-care programs should themselves be primary-care physicians; these educators deserve the same titles and status given other clinical specialists within the academic community. The setting of standards for primary-care practice and the design of research into areas such as the quality of care are tasks that should be undertaken by, or in collaboration with, physicians who are primary-care specialists. (N Engl J Med 293:903–907, 1975)
Encrustation of a Metal Alloy Urinary Stent: A Mechanistic Investigation
Authors: George A. Barbalias, C. Bouropoulos, N.V. Vagenas, N. Bouropoulos, Dimitrios Siablis, Evangelos N. Liatsikos, Dimitrios Karnabatidis, P.G. Koutsoukos
Journal: European Urology (2000)
Mixed Lymphohematopoietic Chimerism and Response in Wegener's Granulomatosis
Authors: Martin Bornhäuser, Martin Aringer, Christian Thiede
Journal: New England Journal of Medicine (2010)

To the Editor: Animal models have shown that allogeneic hematopoietic stem-cell transplantation can lead to remission of experimental autoimmune disease that is attributed to a “graft-versus-autoimmunity” effect,1 wherein donor hematopoietic and immune cells apparently tolerize autoreactive recipient T cells and B cells.2 Autologous hematopoietic stem-cell transplantation is more commonly performed in patients with severe refractory autoimmune disease; allogeneic hematopoietic stem-cell transplantation in such patients has rarely been reported.3 However, remission after autologous hematopoietic stem-cell transplantation may not be durable in many diseases4; therefore, clinical studies exploring the potentially curative approach of allogeneic hematopoietic stem-cell transplantation may be warranted in . . .