tbuckley/cabot-search huggingface dataset:
Antieosinophil serum and the kinetics of eosinophilia in Schistosomiasis mansoni.
Authors: A A Mahmoud, K S Warren, R C Graham
Journal: The Journal of Experimental Medicine (1975)

Mice were exposed to different intensities of infection with Schistosoma mansoni (10, 50, or 200 cercariae) and the kinetics of peripheral and bone marrow eosinophilia was followed for as long as 20 wk. When the schistosomula (immature worms) were migrating from the lungs to the liver there was a mild, transient eosinophilia, but soon after the onset of egg laying by the schistosomes, a major and prolonged increase in eosinophils occurred. This was terminated in the heavier infections by the death of the animals, but showed a spontaneous decline beginning at 18 wk in the lightly infected mice. The effect of S. mansoni eggs on eosinophilia in the blood, bone marrow, and granulomatous lesions was then examined by injecting schistosome eggs into mice intraperitoneally, subcutaneously, and intravenously. While the host response was dependent on the route by which eggs were administered, primary peripheral and bone marrow responses were seen on intravenous injection, and secondary responses occurred on intravenous and subcutaneous injection. In unsensitized and egg-sensitized mice, eosinophils were first seen around eggs injected into the pulmonary microvasculature at 96 and 24 h respectively. When the granulomas were maximal in size eosinophils made up at least 50% of the lesions. Administration of antieosinophil serum profoundly suppressed eosinophils in the peripheral blood, eliminated mature eosinophils and markedly increased eosinophil precursors in the bone marrow, and ablated eosinophils from the tissue lesions, considerably reducing their area.
A3-04: A phase III study by the Norwegian Lung Cancer Group: Pemetrexed + carboplatin vs. gemcitabine + carboplatin as first-line chemotherapy in stage IIIB/IV non-small cell lung cancer
Authors: Bjørn H. Grønberg, Roy Bremnes, Ulf Aasebø, Paal Brunsvig, Øystein Fløtten, Harald Hjelde, Finn Wammer, Frøydis Stornes, Terje Tollåli, Stein Sundstrøm
Journal: Journal of Thoracic Oncology (2007)
EPIDEMIOLOGICAL STUDIES OF CHRONIC FRUSTRATION-HOSTILITY-AGGRESSION STATES
Authors: FREDERICK C. THORNE
Journal: American Journal of Psychiatry (1957)

This paper presents evidence illustrating the transmission of chronic frustration-hostility-aggression states assuming epidemic proportions. Intensive studies were made by clinical-genetic methods of 2 families in both of which the effects of chronic anger states could be demonstrated through 4 generations. It apears that anger has different pathological implications than anxiety in that its outward manifestations may involve other persons in establishing an epidemic of negative reactions. The dynamics of the disorder are outlined with illustrations of individual reactions among those exposed. These frustration-hostility-aggression states are regarded as major psychiatric syndromes since the degrees of personal and social incapacitation may be very great, particularly when many persons become involved in a vicious situational psychopathy.
Particle deposition in the lungs of children.
Authors: D C Muir, A Hislop, L Reid
Journal: Thorax (1969)

Societyreceptor function and importance in states of chronic hypoxia.Microanatomy of Glomic Tissue of the Pulmonary Trunk C. W. EDWARDS The microanatomical structure and cytology of glomic tissue of the pulmonary trunk in man and animals.
RCGP is cleared of ethnic discrimination in clinical skills assessment
Authors: C. Dyer
Journal: BMJ (2014)

A High Court judge has ruled that the clinical skills assessment required to become a GP in the United Kingdom does not unlawfully discriminate against ethnic minority candidates.

The ruling is a blow for the British Association of Physicians of Indian Origin (BAPIO), which brought a legal challenge against the Royal College of General Practitioners and the General Medical Council over the assessment.1

But Mr Justice Mitting said that the association had won “if not a legal victory, then a moral success” and called on the college to act over the disparity in success rates between white UK graduates and those from …
The effect of diabetes on restenosis
Authors: David J. Frid, Donald F. Fortin, Laura R. Gardner, Charlotte L. Nelson, Jack E. Smith, Frank I. Navetta, David S. Rendall, Rui Ramos, William R. Harlan, James E. Tcheng, Christopher M. O'Connor, Thomas C. Wall, Richard S. Stack, Robert M. Califf
Journal: Journal of the American College of Cardiology (1991)
Biologic and Biochemical Analyses of p16INK4a Mutations From Primary Tumors
Authors: W. G. Yarbrough, R. A. Buckmire, M. Bessho, E. T. Liu
Journal: JNCI Journal of the National Cancer Institute (1999)

BACKGROUND: Point mutations in the tumor suppressor gene p16 INK4a (also known as p16, CDKN2, MTS1, and INK4a) are found in many tumor types. Because the function of the products of these naturally occurring mutants has not been fully explored, we investigated the functional activities of a wide range of naturally occurring p16 mutant proteins. METHODS: Sixteen cancer-associated p16 mutant proteins, resulting from missense mutations, were characterized for their ability to bind and inhibit the cyclin-dependent kinases (CDK4 and CDK6) and to induce cell cycle arrest in G 1 phase. RESULTS/CONCLUSIONS: Among 16 mutants analyzed, nine had detectable functional defects. Three mutants (D84V, D84G, and R87P) had defects in CDK binding, kinase inhibition, and cell cycle arrest. The corresponding mutations are located in the third ankyrin repeat in a highly conserved region believed to form the CDK binding cleft. Three mutants (P48L, D74N, and R87L) had defects in kinase inhibition and cell cycle arrest. Among the 10 mutants with normal CDK binding and inhibitory activity, three mutants (N71S, R80L, and H83Y) had defects only in their ability to induce cell cycle arrest. Thus, p16 mutant proteins that retain CDK4 and CDK6 binding may have more subtle functional defects. All nine mutations leading to functional impairments mapped to the central portion of the p16 protein. Ankyrin repeats II and III appear more critical to p16 function, and mutations in ankyrin repeats I and IV are less likely to disrupt p16 function.
THE TREATMENT OF CERTAIN DISEASES OF PROTOZOAL ORIGIN BY TARTAR EMETIC, ALONE AND IN COMBINATION
Authors: A. Castellani
Journal: BMJ (1916)

OCr. 2r, l9I6 552 MXIA -with tlhe greatest amount of infiltration of the tissues with leprosy bacilli, so they ate most interesting and suggestive.It is too early to say whetlher the drug should be pushed to tlle extent of producinig such reactions, but I am inclined -at present to tlhink they ate decidedly beneficial when moderate in degree, wlhile I have as yet seen no ill effect to follow tlhem, altlhough the possibility of dissemination of *tlhe bacilli in the body must not be lost siglht of.Co fnclusions.
Responding to the Outbreak of Invasive Fungal Infections
Authors: Beth P. Bell, Rima F. Khabbaz
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
“Cotton Wool” Appearance of Paget's Disease
Authors: Puneet Bhargava, Jeffrey H Maki
Journal: New England Journal of Medicine (2010)

A 63-year-old man presented with a long-standing history of sinusitis and 3 weeks of frontal headache. The physical examination was unremarkable. The alkaline phosphatase level was elevated at 434 IU per liter (upper limit of the normal range, 129). The serum calcium level was within normal limits. Radiography of the skull (Panel A) showed thickening of the outer and inner tables of the cranial bones, widening of the diploe, and a “cotton wool” appearance caused by irregular areas of sclerosis (arrows). Computed tomography of the skull (Panel B) confirmed bony expansion, cortical bone thickening, and irregular areas of sclerosis (arrows). . . .
Gastroesophageal Scintigraphy with and without Compression
Authors: MARILYN A. SWANSON, KENNETH L. COX, ROBERT A. CANNON
Journal: Clinical Nuclear Medicine (1981)

This study compares the results of radionuclide gastroesophagography performed by the compression and computer-assisted noncompression techniques. The overall accuracy of the compression and noncompression methods was 71% and 84%, respectively. The use of computer processing significantly enhances the ability to detect minor degrees of reflux and may explain the better results obtained with the noncompression method. Other advantages of the noncompression technique include its technical ease and uniformity and the acquisition of more physiologic data for comparison with results of the acid reflux test.
Infant crying in hunter-gatherer cultures
Authors: Hillary N. Fouts, Michael E. Lamb, Barry S. Hewlett
Journal: Behavioral and Brain Sciences (2004)

By synthesizing evolutionary, attachment, and acoustic perspectives, Soltis has provided an innovative model of infant cry acoustics and parental responsiveness. We question some of his hypotheses, however, because of the limited extant data on infant crying among hunter-gatherers. We also question Soltis' distinction between manipulative and honest signaling based upon recent contributions from attachment theory.
Cancer cell–autonomous contribution of type I interferon signaling to the efficacy of chemotherapy
Authors: Antonella Sistigu, Takahiro Yamazaki, Erika Vacchelli, Kariman Chaba, David P Enot, Julien Adam, Ilio Vitale, Aicha Goubar, Elisa E Baracco, Catarina Remédios, Laetitia Fend, Dalil Hannani, Laetitia Aymeric, Yuting Ma, Mireia Niso-Santano, Oliver Kepp, Joachim L Schultze, Thomas Tüting, Filippo Belardelli, Laura Bracci, Valentina La Sorsa, Giovanna Ziccheddu, Paola Sestili, Francesca Urbani, Mauro Delorenzi, Magali Lacroix-Triki, Virginie Quidville, Rosa Conforti, Jean-Philippe Spano, Lajos Pusztai, Vichnou Poirier-Colame, Suzette Delaloge, Frederique Penault-Llorca, Sylvain Ladoire, Laurent Arnould, Joanna Cyrta, Marie-Charlotte Dessoliers, Alexander Eggermont, Marco E Bianchi, Mikael Pittet, Camilla Engblom, Christina Pfirschke, Xavier Préville, Gilles Uzè, Robert D Schreiber, Melvyn T Chow, Mark J Smyth, Enrico Proietti, Fabrice André, Guido Kroemer, Laurence Zitvogel
Journal: Nature Medicine (2014)
Abstract 3418: TWIST1 a new determinant of epithelial to mesenchymal transition in EGFR mutated lung adenocarcinoma
Authors: Karine Pallier, Anatole Cessot, Aurelie Cazes, Pierre-Alexandre Just, Claire Danel, Marc Riquet, Jean-Francois Côté, Stephane Ansieau, Alain Puisieux, Pierre Laurent-Puig, Helene F. Blons
Journal: Cancer Research (2011)

Abstract Metastasis, a recognized multistep biological process, is the main cause of mortality in cancer patients. Although EGFR mutated lung cancers are of better prognosis, a group of patients develop metastasis and died of disease. We previously showed that EGFR mutations were associated with a copy number variation at a locus encompassing the TWIST1 gene on chromosome 7. TWIST1 is a highly conserved developmental gene involved in embryogenesis that turned out to be frequently reactived in cancers promoting both malignant conversion and cancer progression. The aim of this study was to investigate the role of TWIST1 on progression in EGFR mutated lung cancer. Using 6 human lung cell lines with or without EGFR mutations or TWIST1 reactivation, we demonstrated that epithelial-mesenchymal transition (EMT) and the associated mobility were dependent upon TWIST1 expression in cells with EGFR mutation. Indeed, EGF treatment only induced EMT and mobility in cells with TWIST reactivation. EGF treatment induced a translocation of TWIST1 to the nucleus, up-regulated mesenchymal markers and down-regulated epithelial markers at mRNA and protein levels. Moreover, inhibition of either the oncogenic EGF pathway stimulation or TWIST1 expression by small RNA technology reversed the phenomenon suggesting that both EGF pathway activation and TWIST1 reactivation are necessary for EMT in lung cancer with EGFR mutation. In a second step, we analyzed surgical lung cancer specimens from non-smokers with and without EGFR mutations and looked for TWIST1 and epithelial or mesenchymal markers expression. Hierarchical clustering combining TWIST1, epithelial (CDH1, JUP) and mesenchymal (VIM, CDH2) gene mRNA expression in tumors perfectly individualizes the EGFR mutated group as the group with TWIST1 reactivation. Immunohistochemical analysis of lung cancer samples revealed that TWIST1 protein expression was associated with EGFR mutation and low CDH1 expression supporting our in vitro observations. Collectively, our observations support that TWIST1 collaborates with EGF/EGFR mutated signaling pathway in promoting EMT in lung cancers and thereby drives the metastatic dissemination in this group of patients. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3418. doi:10.1158/1538-7445.AM2011-3418
Histological discrimination between autoimmune hepatitis and drug-induced liver injury
Authors: Keiichi Fujiwara, Osamu Yokosuka
Journal: Hepatology (2011)

We read with interest the article by Suzuki et al.1 We were surprised that only 1 (4%) of the autoimmune hepatitis (AIH) cases whose diagnoses were made by experienced hepatologists in Mayo Clinic showed "typical" histology, and that complete agreement on histological diagnosis among four experienced hepatopathologists was less than 50%, if biopsy slides were evaluated blinded to the clinical information. We realized that we should renew our awareness of evaluating liver histology. In daily clinical practice, it is often very difficult in distinguishing drug-induced liver injury (DILI) from AIH with acute presentation of the disease (i.e., acute AIH) as a cause of acute hepatitis. As the investigators described, there is no pathognomonic feature for AIH or DILI, so the evaluation of liver histology in determining AIH versus DILI is important. The diagnosis of AIH is challenging and that of acute onset AIH is even more challenging and difficult, because patients show acute presentation, such as acute hepatitis, and may not have typical clinicopathological features of AIH, and because there is no gold standard for it. Some acute AIH cases are at risk of losing the timing of starting immunosuppressive therapy, develop into severe or fulminant form, and are sometimes resistant to immunosuppressive therapy and have a poor prognosis. It is most important to exclude other causes systematically and apply the International AIH Group original revised scoring system,2 rather than simplified the scoring system.3, 4 Especially, precise pathological evaluation plays an important role in the differential diagnosis.5 As the investigators commented in the Discussion, the sample size was too small and there was a possibility that some of the observed histological features may have been influenced by clinical presentation of AIH (i.e., acute versus chronic presentation). Therefore, it is important to show how many patients of the examined 28 AIH cases were clinically and histologically "acute AIH" who usually present atypical clinicopathological features and may have influenced the histological findings of their study. Keiichi Fujiwara M.D., Ph.D.*, Osamu Yokosuka M.D., Ph.D.*, * Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Randomized Phase II Study of Temozolomide Given Every 8 Hours or Daily With Either Interferon Alfa-2b or Thalidomide in Metastatic Malignant Melanoma
Authors: S. Danson, P. Lorigan, A. Arance, A. Clamp, M. Ranson, J. Hodgetts, L. Lomax, L. Ashcroft, N. Thatcher, M.R. Middleton
Journal: Journal of Clinical Oncology (2003)

Purpose: Temozolomide is an imidazotetrazine with a mechanism of action similar to dacarbazine and equivalent activity in melanoma. It is well tolerated and is a candidate for combination chemotherapy and schedule manipulation. In this study, we combined temozolomide with interferon alfa-2b and, separately, with thalidomide, and we administered temozolomide alone in a compressed schedule. The objectives of this randomized phase II, two-center study were to determine response rates, overall survival, and tolerability of the regimens in patients with advanced metastatic melanoma. Patients and Methods: One hundred eighty-one patients with metastatic melanoma were randomly assigned to receive up to six 4-weekly cycles consisting of temozolomide 200 mg/m 2 every 8 hours for five doses, or temozolomide 200 mg/m 2 daily for days 1 to 5 plus interferon alfa-2b 5 MU (million International Units) subcutaneously three times a week, or temozolomide 150 mg/m 2 (increased after one cycle to 200 mg/m 2 ) daily on days 1 to 5 plus thalidomide 100 mg daily days 1 to 28. Results: The treatment arms were well balanced for known prognostic factors. Median survival was 5.3 months for 8-hourly temozolomide, 7.7 months for temozolomide/interferon, and 7.3 months for temozolomide/thalidomide; and 1-year survivals were 18%, 26%, and 24%, respectively. Response or disease stabilization occurred in 20% of patients (95% confidence interval [CI], 10% to 33%) given 8-hourly temozolomide, 21% (95% CI, 12% to 33%) given temozolomide/interferon, and 25% (95% CI, 15% to 38%) given temozolomide/thalidomide. Grade 3 or 4 nonhematologic toxicities were similar in each arm except for infection, which was more frequent with 8-hourly temozolomide. There were fewer instances of grade 3 or 4 myelotoxicity with temozolomide/thalidomide. Conclusion: Of the three regimens tested, the combination of temozolomide and thalidomide seems the most promising for future study.
TCT-493 Renal Sympathetic Denervation In Patients With Resistant Hypertension - Inducing An Immediate And Persisting 24h Ambulatory Blood Pressure (ABPM) Reduction - Results From The Halle-RDN-Registry
Authors: Alexander Plehn, Sebastian Dietz, Henning Lemm, Maria Leuthold, Silke Markau, Daniel Medenwald, Therese Schubert, Alexander Vogt, Karl Werdan
Journal: Journal of the American College of Cardiology (2013)
Advice on long term corticosteroid treatment may be misleading
Authors: G J Gibson, K Prowse
Journal: BMJ (1997)

<h3>Abstract</h3> Soybean (<i>Glycine max</i>) yields are threatened by multiple stresses including soil salinity. <i>GmSALT3</i> confers net shoot exclusion for both Na+ and Cl<sup>−</sup> and improves salt tolerance of soybean; however, how the ER-localised GmSALT3 achieves this is unknown. Here, GmSALT3’s function was investigated in heterologous systems and near-isogenic lines that contained the full-length <i>GmSALT3</i> (NIL-T; salt-tolerant) or a truncated transcript <i>Gmsalt3</i> (NIL-S; salt-sensitive). GmSALT3 restored growth of K+-uptake-defective <i>E. coli</i> and contributed toward net influx and accumulation of Na+, K+, and Cl<sup>−</sup> in <i>Xenopus laevis</i> oocytes, while <i>Gmsalt3</i> was non-functional. A time-course analysis of the NILs confirmed that shoot Cl<sup>−</sup> exclusion breaks down prior to Na+ exclusion, while grafting showed that shoot Na<sup>+</sup> exclusion occurs via a root xylem-based mechanism. In contrast, NIL-T plants exhibited significantly greater Cl<sup>−</sup> content in both the stem xylem and phloem sap compared to NIL-S, indicating that shoot Cl<sup>−</sup> exclusion likely depends upon novel phloem-based Cl<sup>−</sup> recirculation. NIL-T shoots grafted on NIL-S roots contained low shoot Cl<sup>−</sup>, which confirmed that Cl<sup>−</sup> recirculation is dependent on the presence of GmSALT3 in shoots. Overall, these findings provide new insights on GmSALT3’s impact on salinity tolerance and reveal a novel mechanism for shoot Cl– exclusion in plants. <h3>Highlight</h3> GmSALT3 improves soybean salt tolerance. Here, using heterologous expression, we found GmSALT3 is a functional ion transporter, and, <i>in planta</i> that it confers shoot salt exclusion through root-based Na<sup>+</sup> xylem exclusion and shoot-based Cl<sup>−</sup> exclusion via phloem derived Cl<sup>-</sup> recirculation.
Global nail dystrophy associated with human papillomavirus type 57 infection
Authors: None McCown, None Thiers, None Cook, None Acker
Journal: British Journal of Dermatology (1999)

Verrucae vulgares frequently induce nail dystrophy when infection of the nail matrix occurs. Classic periungual warts are easily recognized by the experienced physician. We report a very unusual presentation of human papillomavirus (HPV) infection of the nail matrix and nail bed involving all 20 nails in an otherwise immunocompetent patient. Viral typing by in situ hybridization revealed HPV type 57. To our knowledge, this is the first association between dystrophy of all 20 nails and HPV infection. However, as the ease of HPV typing improves, a variety of previously unrecognized cutaneous lesions is likely to be associated with HPV infection.
Effect of diazepam on sleep in patients with chronic airflow obstruction.
Authors: J A Wedzicha, P J Wallis, D A Ingram, D W Empey
Journal: Thorax (1988)

The effect of a single dose of diazepam on sleep and respiration was studied in nine patients with chronic airflow obstruction with moderate arterial hypoxaemia but no hypercapnia. Diazepam improved sleep duration without exacerbating nocturnal hypoxaemia and there was no change in the number of apnoeic events after a single 5 mg dose at night.