tbuckley/cabot-search huggingface dataset:
Beware of multiple names in database linkage research: prevalence of aliases in female prison population
Authors: Ruth Elwood Martin, T Gregory Hislop, Garry D Grams, Veronika Moravan, Betty Calam
Journal: BMJ (2005)

A common strategy for health services research involves linking the records held in administrative databases using personal name data.Studies may also require following individuals over time, again necessitating names.Multiple names became a dilemma in our research of a screening intervention for female prisoners in British Columbia, Canada, such that we excluded from database linkage those women's records with at least five surnames or at least four first given names. 1 We found no reports in the health services research literature regarding multiple names.We describe the distribution of aliases within a female prison population and compare the sociodemographic characteristics of prisoners with and without aliases.We discuss the implications for healthcare studies involving people with multiple names.
Acute pancreatitis due to an impacted juxtapapillary duodenal diverticulum
Authors: P. Lim, S. Kim, I. Kim, S. Kim, S.-O. Lee
Journal: Endoscopy (2012)

A 58-year-old woman presented with severe abdominal pain. Laboratory findings showed markedly raised amylase and lipase concentrations at 1169 IU/L and 5040 IU/L respectively. She denied any alcohol consumption. Triglyceride and calcium levels were within the normal range. An abdominal computed tomography (CT) scan showed a round, 2.7-cm, low density, mass-like lesion with a central area of air density in the second part of the duodenum ([Fig. 1]). Esophagogastroduodenoscopy (EGD) revealed a bezoar impacted in a juxtapapillary duodenal diverticulum (JPDD; [Fig. 2]). The hard phytobezoar was broken up and removed using grasping forceps. After the bezoar had been removed, her pancreatitis improved.
THE STRUCTURE AND FUNCTION OF THE PREDOMINATING SYMPTOM IN SOME BORDERLINE CASES
Authors: LEO H. BARTEMEIER
Journal: American Journal of Psychiatry (1960)

The predominating symptoms of the patients I have been describing have been accompanied by anxiety and they have served the function of protecting them from further developments of their psychoses. These are the patients whom a descriptive psychiatrist might classify as borderline because they have neither delusions nor hallucinations and are, therefore, not regarded as legally commitable. They are unlike the ambulatory schizophrenias described by Gregory Zilboorg, but they are representative of patients who suffer from the same group of illnesses, i.e. schizophrenias which are modified by a predominant symptom that is associated with anxiety.
Perineurioma: an uncommon lesion in the gastrointestinal tract
Authors: N. Muguruma, S. Okamura, Y. Imoto, T. Sueuchi, K. Okamoto, H. Fujimoto, K. Arita, T. Hirose, T. Takayama
Journal: Endoscopy (2012)

A 45-year-old man was referred to our hospital with a gastric nodule. Gastroscopy revealed a flat, pale-colored lesion, approximately 15 mm in diameter, in the gastric body. The lesion showed some nodularity but seemed to be covered with a slightly inflamed mucosa ([Fig. 1]). Endoscopic ultrasound (EUS) showed a thickened mucosal layer, as well as scattered, small hypoechoic areas in the submucosal layer ([Fig. 2]).
Standard diagnostic laparoscopy is superior to NOTES approaches: results of a blinded, randomized controlled porcine study
Authors: D. von Renteln, T. Gutmann, A. Schmidt, M. Vassiliou, H. Rudolph, K. Caca
Journal: Endoscopy (2012)

The use of transluminal endoscopic access via the stomach or colon for flexible diagnostic peritoneoscopy has been proposed, although the diagnostic value of the technique has not yet been fully clarified. In this animal trial, the two main natural orifice transluminal endoscopic surgery (NOTES) approaches - transgastric (TG) and transcolonic (TC) - were compared with standard transabdominal access using both rigid (TAR) and flexible instruments (TAF) for diagnostic laparoscopy. A total of 48 peritoneoscopies were performed using two randomly assigned approaches in 24 anesthetized pigs. The ability of the examinations to detect 576 electrocautery markings simulating intraperitoneal metastases, to achieve complete organ visualization, and to simulate organ biopsies was analyzed. Sensitivities for the detection of lesions were 78.5 %, 59.7 %, 48.6 %, and 38.9 % for TAR, TAF, TC, and TG, respectively; standard laparoscopy was superior to all other approaches (P < 0.01). Among the NOTES approaches, TC was superior for examining the upper abdomen (P = 0.03). Complete organ visualization was better with the transabdominal approach (visual analogue scale TAR 7.15, TAF 6.71) than with the NOTES access routes (TC 5.07, TG 4.35); standard rigid laparoscopy was superior to both NOTES approaches (P < 0.01). Organ biopsy simulation was possible in 87 %, 85 %, 72 %, and 65 % of cases with TAR, TAF, TC, and TG, respectively. Standard rigid laparoscopy was again superior to both NOTES approaches (TAR vs. TC, P = 0.03; TAR vs. TG, P < 0.01). In this experimental trial, rigid standard laparoscopy provided better organ visualization, better lesion detection, and better biopsy capability than the transgastric and transcolonic NOTES approaches. In its current form, NOTES appears to be unsuitable for diagnostic laparoscopy.
Role of microtubules in ischemic preconditioning against myocardial infarction
Authors: Y NAKAMURA, T MIURA, A NAKANO, Y ICHIKAWA, T YANO, H KOBAYASHI, Y IKEDA, T MIKI, K SHIMAMOTO
Journal: Cardiovascular Research (2004)

Objective: The role of microtubules in ischemic preconditioning (PC) was investigated in isolated perfused rabbit hearts.
183. Development of Ex-Vivo Gene Therapy Procedures for Central Nervous System Diseases, Based on Homologous Recombination in Human Neural Stem Cells
Authors: Carlos A. Bueno Lopez, Alberto Martinez Serrano
Journal: Molecular Therapy (2005)

Current experimental gene therapy procedures for neurodegenerative diseases of the nervous system generally pose safety problems, are not highly reproducible, nor predictable, and are of limited duration. The work reported here aims at developing a new ex-vivo gene therapy system based on homologous recombination [HR] in human neural stem cells [hNSCs].This strategy should allow to carry out gene transfer in a controlled, efficient and completely safe way, in the long term, while also offering the possibility of physiological regulation of the transgene expression.
Effect of coroners' rules on death certification for alcoholic liver disease.
Authors: J D Maxwell, P Knapman
Journal: BMJ (1985)

Etude retrospective des certificats de deces de malades morts d'affections hepatiques d'origine alcoolique ou non. Les certificats sont souvent vagues ou incorrects, en cas d'affection d'origine alcoolique, dans les annees ou la loi considerait ces maladies comme entrant dans la categorie des intoxications, ce qui necessitait une enquete. la modification de la loi permet (depuis 1984) une amelioration des certificats de deces
Another hazard of gold therapy.
Authors: J A Rennie
Journal: Annals of the Rheumatic Diseases (1982)

reading the paper by Dr Gibson and his colleagues deal- ing with the influence of allopurinol treatment on renal function in gout.'In the discussion which followed the original presentation of this work at the society's meeting in November 1979 several speakers pointed out impor- tant criticisms of design and analysis which these authors have left unanswered.In my opinion these errors must continue to cast doubt on the validity of the conclusions they have drawn.Central to these criticisms is the allocation of patients to treatment groups.Three patients who were prescribed col-
Students Challenged to Make Ethics Part of Their 'Habit of Thought'
Authors: Teri Randall
Journal: JAMA (1992)

FOR 100 YEARS, Creighton University School of Medicine, has had to deal with a challenge to which the majority of medical schools haven't had to devote one moment of thought: how to remain faithful to the specific religious tradition upon which the school was founded and at the same time prepare students-from a variety of religious and nonreligious perspectives—for a secular world. One of the most distinguishing characteristics of this medical school is that, as one of only four Jesuit medical schools in the country, it continuously seeks to define its Roman Catholic identity and the way this is manifested in contemporary medical education. Perhaps one of the most evident manifestations is Creighton's heavy emphasis on medical ethics, in both teaching and research. Creighton's Center for Health Policy and Research has seven faculty members, a remarkably large program for a school of this size. The faculty comes from a broad
Diastolic Tissue Doppler Indexes Correlate With the Degree of Collagen Expression and Cross-Linking in Heart Failure and Normal Ejection Fraction
Authors: Mario Kasner, Dirk Westermann, Begoña Lopez, Regina Gaub, Felicitas Escher, Uwe Kühl, Heinz-Peter Schultheiss, Carsten Tschöpe
Journal: Journal of the American College of Cardiology (2011)
Abstract 3490: Measurement of Gifinitib (ZD1839) effect on electrophysiological properties of head and neck cancer cells using Dielectrophoresis (DEP)
Authors: Sina Mahabadi, Michael Pycraft Hughes, Fatima Hanna Labeed
Journal: Cancer Research (2014)

Abstract Introduction: Dielectrophoresis (DEP) is a physical phenomenon which can be used to determine the dielectric properties of the cells through applying a non-uniform electric field. Electrophysiological properties such as the conductivity and permittivity of the membrane and cytoplasm can be determined by this method, which has already been applied in cancer research. Gifinitib (Iressa) or ZD1839 is one of the most commonly used drugs for treatment of cancer such as breast and head and neck. This drug damages the local tumours through blocking the activity of EGFR (epidermal growth factor receptor) which is one of the most common factors in proliferation of the cancer cells. In this study, the effect of Gifinitib (Iressa) treatment was investigated through analysis of the electrophysiological properties of the HN5 (Head and Neck Carcinoma cells) using a DEPtech 3DEP dielectrophoresis analysis device. Results: The cell membrane capacitance for HN5 cells post twenty two hours of drug treatment became substantially lower. Significant changes were also observed in the cytoplasm over the 22-hour period. Conclusion: The results indicated a substantial reduction in the membrane parameters of HN5 cells, and these results can be attributed to the interaction between the drug and the EGFR in these cells. DEP appeared to be a reliable method for assessing the action of EGFR inhibitors for drug discovery. Citation Format: Sina Mahabadi, Michael Pycraft Hughes, Fatima Hanna Labeed. Measurement of Gifinitib (ZD1839) effect on electrophysiological properties of head and neck cancer cells using Dielectrophoresis (DEP). [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3490. doi:10.1158/1538-7445.AM2014-3490
Small nucleolar RNA expression profiling identifies potential prognostic markers in peripheral T-cell lymphoma
Authors: Wilfried Valleron, Loic Ysebaert, Laure Berquet, Virginie Fataccioli, Cathy Quelen, Antoine Martin, Marie Parrens, Laurence Lamant, Laurence de Leval, Christian Gisselbrecht, Philippe Gaulard, Pierre Brousset
Journal: Blood (2012)
Anaphylaxis after dichloralphenazone treatment.
Authors: S Perl
Journal: BMJ (1977)

2 Total mortality IcVM P150 - ll, 0 50 0 Cholesterol TryglycerideWt Ht Wt Ht <78 >78 <7-8 >78 <17 >17 <17 >17 <44 >44 <44 >44 Non-smokers Smokers Non-smokers Smokers Non-smokers Smokers FIG 4-Total mortality and cardiovascular mortality in relation to cigarette smoking and other variables.
Heparin‐induced thrombocytopenia presenting with thrombosis of multiple saphenous vein grafts and myocardial infarction
Authors: Ernesto Ayala, Manuel F. Rosado, Daniel Morgensztern, Mohamed A. Kharfan‐Dabaja, John J. Byrnes
Journal: American Journal of Hematology (2004)

Abstract We report herein a patient with coronary artery disease that developed heparin‐induced thrombocytopenia after coronary artery bypass graft with resulting thrombosis of multiple saphenous vein grafts and myocardial infarction after heparin exposure. The patient required lepirudin and a cardiac catheterization with placement of stents. Am. J. Hematol. 76:383–385, 2004. © 2004 Wiley‐Liss, Inc.
Treatment of patients with psoriasis by PUVA therapy and mechlorethamine
Authors: G. MAUDUIT, G. SALLE, A.M. SCHOTT, J. THIVOLET
Journal: British Journal of Dermatology (1986)

Journal Article Treatment of patients with psoriasis by PUVA therapy and mechlorethamine Get access G. MAUDUIT, G. MAUDUIT Clinique Dermatologique, INSERM U. 209, Hopital Edouard Herriot, 69437 Lyon Cédex 08, France Search for other works by this author on: Oxford Academic Google Scholar G. SALLE, G. SALLE Clinique Dermatologique, INSERM U. 209, Hopital Edouard Herriot, 69437 Lyon Cédex 08, France Search for other works by this author on: Oxford Academic Google Scholar A.M. SCHOTT, A.M. SCHOTT Clinique Dermatologique, INSERM U. 209, Hopital Edouard Herriot, 69437 Lyon Cédex 08, France Search for other works by this author on: Oxford Academic Google Scholar J. THIVOLET J. THIVOLET Clinique Dermatologique, INSERM U. 209, Hopital Edouard Herriot, 69437 Lyon Cédex 08, France Professor J.Thivolet. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 115, Issue s31, 1 August 1986, Pages 82–85, https://doi.org/10.1111/j.1365-2133.1986.tb02115.x Published: 01 August 1986
Serum levels of type I procollagen C-terminal propeptide, insulin-like growth factor-I (IGF-I), and IGF binding protein-3 in obese children and adolescents: Relationship to gender, pubertal development, growth, insulin, and nutritional status
Authors: Adriano Falorni, Vittorio Bini, Gabriele Cabiati, Francesco Papi, Sergio Arzano, Federica Celi, Massimo Sanasi
Journal: Metabolism (1997)
Comparison of surrogate and direct measurement of insulin resistance in chronic hepatitis C virus infection: Impact of obesity and ethnicity
Authors: Khoa D. Lam, Peter Bacchetti, Fahim Abbasi, Claudia E. Ayala, Samuel M. Loeb, Vidhi Shah, Michael J. Wen, Gerald M. Reaven, Jacquelyn J. Maher, Mandana Khalili
Journal: Hepatology (2010)

Studies using surrogate estimates show high prevalence of insulin resistance in hepatitis C infection. This study prospectively evaluated the correlation between surrogate and directly measured estimates of insulin resistance and the impact of obesity and ethnicity on this relationship. Eighty-six nondiabetic, noncirrhotic patients with hepatitis C virus (age = 48 ± 7 years, 74% male, 44% white, 22% African American, 26% Latino, 70% genotype 1) were categorized into normal-weight (body mass index [BMI] &lt; 25, n = 30), overweight (BMI = 25-29.9, n = 38), and obese (BMI ≥ 30, n = 18). Insulin-mediated glucose uptake was measured by steady-state plasma glucose (SSPG) concentration during a 240-minute insulin suppression test. Surrogate estimates included: fasting glucose and insulin, glucose/insulin, homeostasis model assessment (HOMA-IR), quantitative insulin sensitivity check index (QUICKI), insulin (I-AUC) and glucose (G-AUC) area under the curve during oral glucose tolerance test, and the Belfiore and Stumvoll indexes. All surrogate estimates correlated with SSPG, but the magnitude of correlation varied (r = 0.30-0.64). The correlation coefficients were highest in the obese. I-AUC had the highest correlation among all ethnic and weight groups (r = 0.57-0.77). HOMA-IR accounted for only 15% of variability in SSPG in the normal weight group. The common HOMA-IR cutoff of ≤3 to define insulin resistance had high misclassification rates especially in the overweight group independent of ethnicity. HOMA-IR &gt; 4 had the lowest misclassification rate (75% sensitivity, 88% specificity). Repeat HOMA-IR measurements had higher within-person variation in the obese (standard deviation = 0.77 higher than normal-weight, 95% confidence interval = 0.25-1.30, P = 0.005). Conclusion: Because of limitations of surrogate estimates, caution should be used in interpreting data evaluating insulin resistance especially in nonobese, nondiabetic patients with HCV. Hepatology 2010
Genotype-Phenotype Aspects of Type 2 Long QT Syndrome
Authors: Wataru Shimizu, Arthur J. Moss, Arthur A.M. Wilde, Jeffrey A. Towbin, Michael J. Ackerman, Craig T. January, David J. Tester, Wojciech Zareba, Jennifer L. Robinson, Ming Qi, G. Michael Vincent, Elizabeth S. Kaufman, Nynke Hofman, Takashi Noda, Shiro Kamakura, Yoshihiro Miyamoto, Samit Shah, Vinit Amin, Ilan Goldenberg, Mark L. Andrews, Scott McNitt
Journal: Journal of the American College of Cardiology (2009)
Census of mental hospital patients and life expectancy of those unlikely to be discharged.
Authors: T Bewley, J M Bland, M Ilo, E Walch, G Willington
Journal: BMJ (1975)

A census in a London mental hospital was performed so that the numbers of patients requiring permanent care for the next 20 to 40 years could be estimated. Of 1467 resident patients 20% had been admitted in the preceding five months and 15% in the year before that. Of the 65% who had been in hospital for over 17 months 1% (16 patients) had been in hospital for over 5o years. Altogether 257 (18%) patients would probably be discharged, 339 (23%) might possibly be discharged if there were adequate community facilities, but 871 (59%) were not likely to be discharged; 239 patients under the age of 65 who had been admitted between 1950 and 1973 were unlikely to be discharged. There were about 10 new younger long-stay patients from each year's admissions. Three conditions--schizophrenia, organic brain syndrome, and affective illness--affected 79% of the population. Fourteen per cent had been employed on admission and 28% were considered employable or possibly employable. Half of those who might be considered for discharge (296) would need a hostel. No rehabilitation was needed or possible for 40% of the patients; 299 (20%) patients were chairbound or bedridden and 400 (27%) were totally dependent on nursing and 587 (40%) partly dependent. Twenty months after the census 361 (25%) patients had left (59 had been readmitted), 284 (19%) had died, and 822 (56%) had remained as inpatients. The most realistic future prediction was that 210 (14%) of these patients would still be in the hospital in 20 years and 43 (3%) in 40 years. In the light of these findings and the scarceness of resources current Department of Health and Social Security plans for phasing out mental hospitals must be challenged.
Physical Activity, Diet, and Risk of Alzheimer Disease
Authors: Nikolaos Scarmeas
Journal: JAMA (2009)

Both higher adherence to a Mediterranean-type diet and more physical activity have been independently associated with lower Alzheimer disease (AD) risk but their combined association has not been investigated.To investigate the combined association of diet and physical activity with AD risk.Prospective cohort study of 2 cohorts comprising 1880 community-dwelling elders without dementia living in New York, New York, with both diet and physical activity information available. Standardized neurological and neuropsychological measures were administered approximately every 1.5 years from 1992 through 2006. Adherence to a Mediterranean-type diet (scale of 0-9; trichotomized into low, middle, or high; and dichotomized into low or high) and physical activity (sum of weekly participation in various physical activities, weighted by the type of physical activity [light, moderate, vigorous]; trichotomized into no physical activity, some, or much; and dichotomized into low or high), separately and combined, were the main predictors in Cox models. Models were adjusted for cohort, age, sex, ethnicity, education, apolipoprotein E genotype, caloric intake, body mass index, smoking status, depression, leisure activities, a comorbidity index, and baseline Clinical Dementia Rating score.Time to incident AD.A total of 282 incident AD cases occurred during a mean (SD) of 5.4 (3.3) years of follow-up. When considered simultaneously, both Mediterranean-type diet adherence (compared with low diet score, hazard ratio [HR] for middle diet score was 0.98 [95% confidence interval {CI}, 0.72-1.33]; the HR for high diet score was 0.60 [95% CI, 0.42-0.87]; P = .008 for trend) and physical activity (compared with no physical activity, the HR for some physical activity was 0.75 [95% CI, 0.54-1.04]; the HR for much physical activity was 0.67 [95% CI, 0.47-0.95]; P = .03 for trend) were associated with lower AD risk. Compared with individuals neither adhering to the diet nor participating in physical activity (low diet score and no physical activity; absolute AD risk of 19%), those both adhering to the diet and participating in physical activity (high diet score and high physical activity) had a lower risk of AD (absolute risk, 12%; HR, 0.65 [95% CI, 0.44-0.96]; P = .03 for trend).In this study, both higher Mediterranean-type diet adherence and higher physical activity were independently associated with reduced risk for AD.
Abstract 5592: Lovastatin and low dose celecoxib decrease proliferation and inflammation in a cellular model of lung pre-malignancy
Authors: Jeanette L. Grant, Tonya C. Walser, Jane Yanagawa, Gina Lee, John D. Minna, Sri Prasad, Saswati Hazra, Steven M. Dubinett
Journal: Cancer Research (2010)

Abstract Statin drugs, such as lovastatin and pravastatin, block the cellular synthesis of cholesterol by inhibiting the function of HMG-CoA reductase. In a prospective study, patients undergoing statin treatment for prevention of atherosclerosis were at a lower risk of developing certain cancers, including lung and breast, suggesting a possible use for lovastatin in the chemoprevention of lung cancer. Here, we show that lovastatin dose-dependently decreases proliferation in both histologically normal and Kras-mutated human bronchial epithelial cells (HBECs) through the inhibition of cholesterol production. However, increased expression of PGE2, which we and others have shown to contribute to lung cancer progression, was noted with lovastatin treatment alone. Lovastatin up-regulates the production of PGE2 by up-regulating COX-2 expression and simultaneously down-regulating metabolism of PGE2 via down-regulation of 15-PGDH expression. Treatment with the cholesterol precursor, mevalonic acid, inhibited up-regulation of PGE2 and blocked dose-dependent anti-proliferative activity of lovastatin, indicating sterol-dependence. Treatment with both lovastatin and low dose (0.1uM) celecoxib, a COX-2 inhibitor, decreased PGE2 protein production in vector control and Kras-mutated HBECs. These findings suggest that the combination of lovastatin and low dose celecoxib overcomes up-regulation of PGE2 by lovastatin alone and that the combination represents a potentially effective lung cancer chemopreventative regimen worthy of further investigation. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 5592.
Kenneth Fawcett Mole
Authors: A. Fraser, M. Laurence
Journal: BMJ (2010)

Kenneth Fawcett Mole was born in China, where his father was a medical missionary. Returning to England for his final schooling, he won an organ scholarship to Oxford, where he read classics and philosophy. At the outbreak of the second world war his grounding in Buddhist philosophy led him to register as a conscientious objector, and he joined the Friends Ambulance Service, but his experiences with them during the London Blitz made him enlist in the armed services. Posted to India with the Royal Air Force, he was recruited into the Intelligence …