tbuckley/cabot-search huggingface dataset:
Fertility after Unilateral Orchidectomy and Radiotherapy for Patients with Malignant Tumours of the Testis
Authors: D. W. Smithers, D. M. Wallace, D. E. Austin
Journal: BMJ (1973)

The results of treatment for patients with seminoma of the testis by orchidectomy and irradiation are so satisfactory that retroperitoneal lymph node dissection is no longer practised. However, this operation is still used routinely in some centres for patients with testicular teratomas despite the lack of evidence that it gives better results than those obtained with irradiation followed by removal of lymphographically demonstrable residual tumour and in the face of the high incidence of ejaculatory impotence which follows. On grounds of preservation of sexual function and fertility there is a great advantage to be gained from the latter form of treatment. Thirty-four of our patients between the ages of 25 and 45 years treated by irradiation to the para-aortic and iliac nodes for testicular tumours fathered 52 children to term after their treatment.
Coronary artery disease and its management: Influence on survival in patients undergoing aortic valve replacement
Authors: Charles J. Mullany, Lila R. Elveback, Robert L. Frye, James R. Pluth, William D. Edwards, Thomas A. Orszulak, Louis A. Nassef, Ronald E. Riner, Gordon K. Danielson
Journal: Journal of the American College of Cardiology (1987)
Screening, ethics and the law.
Authors: T. M. Marteau
Journal: BMJ (1992)

Vitamin C depletion and pressure sores EDITOR,-Helen F Goode and colleagues cite the main risk factors for pressure sores in elderly people-namely, acute illness, poor mobility, long periods on high pressure surfaces, incontinence, and confusion.'They did not control for these effects so are unwise to conclude that there is a significant association between vitamin C and the development of pressure sores in elderly subjects with femoral neck fractures, particularly since the patients were unselected.Rather than seek a "clear cut risk factor which determines why one patient should develop a sore given the same conditions as another patient," the authors could perhaps have used an instrument such as the Waterlow pressure sore assessment score.2This instrument acknowledges that the risk of developing pressure sores is multifactorial, but its application allows an appropriate care plan to be constructed, including the allocation of equipment such as mattresses to prevent the condition arising in the first place.'Such a system is used routinely in many units caring for elderly people.
Reply to the Letter to the Editor on ‘Severe hepatic sinusoidal obstruction and oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer: a real entity?’, by M. Sebagh, M. Plasse, F. Lévi &amp; R. Adam (Ann Oncol 2005; 16: 331)
Authors: L. Rubbia-Brandt, G. Mentha, B. Dousset, B. Terris
Journal: Annals of Oncology (2005)
Severe outbreak of surgical sepsis due to Staphylococcus aureus of unusual type and origin.
Authors: R W Payne
Journal: BMJ (1967)

Outbreaks of staphylococcal infection in hospital due to infec- tion arising in the operating-theatre are probably less rethan reports hi the literature would suggest.There are many pos- sible explanations for this natural reticence.However, it is telt that the following outbreak should be Worded since there are a humber of features of general interest. Outbreak in Outfi0iThe outbreak occurred at St. Albans City Hospital-a 400- bedded procial general hospital-in January 1963.Each surgical ward has for some years maintained a wound infection register and it has been the of the clinical pathology department to keep a rewd of all oagulase-positive staphylococci (Staphylococcus aureus) iated from patients n the hospital; a record is also kept of the antibiotic senidvity pattern of each organism.In January 1963 the numbe of patients from whom Staph.aureus was isolated begn to rise (Fig. 1).Nearly all these organs were nt to penicillin, streptomycin, and tetracycline when tested by a routine Multodisk diffusion method.This was a pattern of antibiotic resistance that was uncommon in the hospital at the time.
Abstract 1322: Sensitizing radiation-induced integrin β-1 signaling by targeting uPAR in medulloblastoma cells
Authors: Arun Kumar Nalla, Rama Prasadarao Kotipatruni, Purnachandra Nagaraju Ganji, Daniel Fassett, Jeffrey D. Klopfenstein, Dzung H. Dinh, Meena Gujrati, Jasti S. Rao
Journal: Cancer Research (2010)

Abstract Although radiation is an effective therapy, it has several adverse effects, including the induction of secondary (new) tumor within the irradiated field. Several studies have reported this effect with medulloblastoma despite effective radiotherapy during the initial stages. Here, we attempt to capitalize on the radiation-induced aggressive behavior of medulloblastoma cells by examining migration, cell adhesion and matrigel invasion properties. Comparison at the mRNA levels between the matrigel-invading and non-invading cells (with and without radiation) clearly demonstrates the aggressiveness of irradiated medulloblastoma cells. RT-PCR analysis confirmed the increased expression of uPA, uPAR, focal adhesion kinase (FAK), N-Cadherin, and integrins like α3, α5, β1 and β6 in irradiated cells. Increased expression of uPAR and integrin β-1 in irradiated cells was also confirmed by immunofluorescence and immunoprecipitation assays. The interaction between uPAR and integrin β-1 and subsequent downstream signaling is a key process in malignant progression and metastasis and has been recently reported in mediating resistance to radiation. With this view, we aimed to study the effect of siRNA-mediated knockdown of uPAR on cell migration and adhesion in irradiated and non-irradiated medulloblastoma cells. Downregulation of uPAR not only reduced cell migration and adhesion, but also reduced the increased migration and adhesiveness associated with irradiated cells. Apart from specific knockdown of uPAR in siRNA-transfected cells, the increased expression of uPAR and integrin β-1 upon radiation were also reduced both at the transcript and protein levels. Studies of the uPAR/integrin β-1 downstream signaling cascade have shown that uPAR knockdown reduces both the expression and phosphorylation of FAK, paxillin, p130Cas and Rac-1, which are known to be actively involved in coordinating tyrosine kinase based signaling related to cell migration and adhesion. Our in vitro results demonstrate that targeting uPAR might sensitize the radiation-induced aggressiveness of medulloblastoma cells by affecting the uPAR/integrin β-1 signaling pathway. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1322.
Peak Oxygen Uptake Better Predicts Outcome Than Submaximal Respiratory Data in Heart Transplant Candidates
Authors: Karel Pardaens, Johan Van Cleemput, Johan Vanhaecke, Robert H. Fagard
Journal: Circulation (2000)

Many studies have focused on the prognostic power of peak oxygen uptake VO(2) in patients with chronic heart failure, but maximal exercise testing is not without risk. The purpose of the present study was, therefore, to assess the prognostic significance of the steepness of changes in ventilation and carbon dioxide output VO(2) during submaximal exercise in comparison with VO(2).The study population consisted of 284 adult heart transplant candidates who performed a graded maximal bicycle ergometer test with respiratory gas analysis. Using the respiratory data up to a gas exchange ratio of 1.0, 3 submaximal slopes were calculated in each patient. During follow-up (median, 1.33 years), 57 patients died and 149 had >/=1 cardiovascular event. When using Cox proportional hazards analysis, both peak VO(2) and submaximal respiratory slopes predicted outcome before and after accounting for age, sex, and body mass index. However, whereas the prognostic power of peak VO(2) was independent of submaximal respiratory data, the prognostic significance of the slopes was lost after controlling for peak VO(2). Stepwise regression analysis even selected peak VO(2) as an independent prognostic index among the following factors: cause of heart failure, ejection fraction, pulmonary vascular resistance, natremia, and the forced expiratory volume in 1 s.Respiratory data during submaximal exercise are significant predictors of outcome in patients with chronic heart failure, but their prognostic power is inferior to that of peak VO(2). However, these data may be useful when maximal exercise is contraindicated or not achievable.
Functional analysis of naturally occurring DCLRE1C mutations and correlation with the clinical phenotype of ARTEMIS deficiency
Authors: Kerstin Felgentreff, Yu Nee Lee, Francesco Frugoni, Likun Du, Mirjam van der Burg, Silvia Giliani, Ilhan Tezcan, Ismail Reisli, Ester Mejstrikova, Jean-Pierre de Villartay, Barry P. Sleckman, John Manis, Luigi D. Notarangelo
Journal: Journal of Allergy and Clinical Immunology (2015)
Role of passive T-cell death in chronic experimental autoimmune encephalomyelitis
Authors: Shohreh Issazadeh, Kald Abdallah, Tanuja Chitnis, Anil Chandraker, Andrew D. Wells, Laurence A. Turka, Mohamed H. Sayegh, Samia J. Khoury
Journal: Journal of Clinical Investigation (2000)

The mechanisms of chronic disease and recovery from relapses in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis, are unknown. Deletion of myelin-specific lymphocytes by apoptosis may play a role in termination of the inflammatory response. One pathway of apoptosis is the passive cell death or “cell death by neglect” pathway, which is under the control of the Bcl family of genes. To investigate the role of passive cell death pathway in EAE, we used mice with transgenic expression of the long form of the bcl-x gene (Bcl-xL) targeted to the T-cell lineage. We found that mice transgenic for Bcl-xL have an earlier onset and a more chronic form of EAE induced by myelin oligodendrocyte glycoprotein (MOG) peptide 35–55 compared with wild-type littermate mice. This was not due to an expanded autoreactive cell repertoire. Primed peripheral lymphocytes from Bcl-xL transgenic mice showed increased proliferation and cytokine production to MOG peptide in vitro compared with lymphocytes from wild-type animals. Immunohistologic studies demonstrated increased cellular infiltrates, immunoglobulin precipitation, and demyelination in the Bcl-xL transgenic central nervous system (CNS) compared with controls. There was also a decreased number of apoptotic cells in the CNS of Bcl-xL transgenic mice when compared with littermates at all time points tested. This is the first report of an autoimmune disease model in Bcl-xL transgenic mice. Our data indicate that the passive cell death pathway is important in the pathogenesis of chronic EAE. These findings have implications for understanding the pathogenesis of multiple sclerosis and other autoimmune diseases.
Diuretic treatment of resistant hypertension.
Authors: L E Ramsay, J H Silas, S Freestone
Journal: BMJ (1980)

In patients with hypertension resistant to three or four drugs including a thiazide diuretic substitution of frusemide for the thiazide, or the addition of spironolactone, produced significant reductions in blood pressure and body weight. The response did not depend on the presence of overt fluid retention, renal impairment, or the use of antihypertensive drugs of high potency. Women had larger responses than men. Expansion of the plasma or extracellular fluid volume is an important cause of resistance to treatment even when a thiazide diuretic is used. An increase in diuretic treatment should be tried before using the postganglionic adrenergic blockers or minoxidil in resistant hypertension.
Abstract 3592: Preclinical combination strategies for development of JI-101, a selective inhibitor of Ephrin B4, VEGF R2 and PDGF-Rβ
Authors: Glynn W. Gilcrease, Mark Wade, Ramesh Mullangi, Sreesha Srinivasa, Jonathan Northrup, Raman Govindarajan, Sunil Sharma
Journal: Cancer Research (2011)

Abstract Background: JI-101 is a novel, highly selective and potent angiogenesis inhibitor with unique EphB4 activity along with VEGFR2 and PDGFRβ inhibitor activity. JI-101 shows a good pre-clinical profile and is well tolerated to date in phase 1 and early phase 2 clinical trials. In order to investigate combination partners, in vitro and in vivo studies were undertaken to combine JI-101 with chemotherapies and various targeted agents. Materials and Methods: Cancer cell lines from different tissue types were seeded on 96 well plates at a density of 2,000 cell per well and allowed to adhere overnight. To determine if JI101 could enhance the toxic effects of traditional chemotherapy, cells were incubated with 10-0.003 μM Gemcitabine, Oxaliplatin and 5-Fluorouricil in the presence or absence of 1 μM JI101. To determine the effect of JI101 with other targeted therapies, cells were incubated with 10-0.03 μM JI101, Axitininb, and Imantinib and 1-0.003 μM BEZ235. In addition, cells incubated with BEZ235 were combined with 1 μM of JI101, Axitininb or Imatinib. Cells were incubated with the drugs for 96 hours at 37oC in a cell culture incubator. After incubation cell viability was tested with the MTS Assay. Results: Toxicity profiles of traditional chemotherapies were not significantly altered when combined with JI101. Incubation of BEZ235 with multiple cancer cell lines resulted in dose dependent toxicity to the cells whereas JI101, Axitinib and Imatinib showed little to no toxicity in the cancer cell lines tested. Coincubation of the PI3 kinase/mTOR inhibitor BEZ235 with JI101, an EphB4, VEGFR2, and PDGF-Rβ or Axitinib a specific VEGF-R2 inhibitor enhanced the cellular toxicity of BEZ235 in a cell line specific manner. Conclusions: JI-101 is highly synergistic with mTOR inhibitors and PI 3 kinase inhibitors in vitro and in vivo. The molecular mechanism will be presented for this synergy. A combination trial of JI101 and PI3 kinase inhibitor or JI101 and mTOR inhibitor is indicated. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3592. doi:10.1158/1538-7445.AM2011-3592
Effect of inhibition of lipolysis on heart failure following acute coronary occlusion in the dog
Authors: J. K. Kjekshus
Journal: Cardiovascular Research (1974)

The extent and severity of myocardial ischaemic injury produced by acute coronary artery occlusion has been found to be effectively reduced by inhibiting hormone sensitive lipase activity. Results suggest that the 'power failure' induced by occlusion of a major coronary artery is less severe during antilipolytic treatment than during control occlusion without treatment.
Genome-Wide Linkage Analysis of Systolic and Diastolic Blood Pressure
Authors: Treva Rice, Tuomo Rankinen, Michael A. Province, Yvon C. Chagnon, Louis Pérusse, Ingrid B. Borecki, Claude Bouchard, D. C. Rao
Journal: Circulation (2000)

Blood pressure (BP), an important risk factor for coronary heart disease, is a complex trait with multiple genetic etiologies. While some loci affecting BP variation are known (eg, angiotensinogen), there are likely to be novel signals that can be detected with a genome scan approach.A genome-wide scan was performed in 125 random and 81 obese families participating in the Québec Family Study. A multipoint variance-components linkage analysis of 420 markers (353 microsatellites and 67 restriction fragment length polymorphisms) revealed several signals (P:<0.0023) for systolic BP on 1p (D1S551, ATP1A1), 2p (D2S1790, D2S2972), 5p (D5S1986), 7q (D7S530), 8q (CRH), and 19p (D19S247). Suggestive evidence (0.0023<P:<0.01) was found on 3q, 10p, 12p, 14q, and 22q. The results were encouraging for HSD3B1 (P:<0.03), AGT (P:<0.03), ACE (P:<0.02), and adipsin (P:<0.005) but null with regard to other candidates (eg, renin, and glucocorticoid and adrenergic receptors).Multiple linkage regions support the notion that risk for hypertension is due to multiple (ie, oligogenic) susceptibility loci. Comparisons across the complete, random, and obese samples suggest that some regions are specific to BP and others may involve obesity (eg, pleiotropy, epistasis, or gene-environment interaction). Some of these areas harbor known candidates. Others involve novel regions, some of which replicate previous reports and provide a focus for future studies to identify novel genes that influence interindividual variation in BP.
EXPERIMENTAL CHROMIUM DERMATITIS
Authors: CAREY P. McCORD
Journal: JAMA (1930)

One of the hoary traditions of industrial hygiene is that chromium compounds will not attack the unbroken skin. In view of the increasing use of chromium through the advent of chromium plating, stainless steel and photolithography, all resulting in increased exposure to chromium, it becomes desirable to point out the error in the assumption that a break in the integument is requisite to chromium action. In the past, chromium dermatoses with a preinjured skin have been described, but these statements have been effectively overshadowed by the repeated implication that an injured skin is a necessary forerunner to chromium action. This situation is largely due to confusion between "chrome holes" and chromium dermatitis. The deep undermining "chrome hole" is nearly always preceded by a break in the integument, while the superficial dermatitis may follow direct irritation of normal skin. In support of this attitude we present observations from the experimental application
Peptidases released by necrotic cells control CD8+ T cell cross-priming
Authors: Jaba Gamrekelashvili, Tamar Kapanadze, Miaojun Han, Josef Wissing, Chi Ma, Lothar Jaensch, Michael P. Manns, Todd Armstrong, Elizabeth Jaffee, Ayla O. White, Deborah E. Citrin, Firouzeh Korangy, Tim F. Greten
Journal: Journal of Clinical Investigation (2013)

Cross-priming of CD8+ T cells and generation of effector immune responses is pivotal for tumor immunity as well as for successful anticancer vaccination and therapy. Dead and dying cells produce signals that can influence Ag processing and presentation; however, there is conflicting evidence regarding the immunogenicity of necrotic cell death. We used a mouse model of sterile necrosis, in which mice were injected with sterile primary necrotic cells, to investigate a role of these cells in priming of CD8+ T cells. We discovered a molecular mechanism operating in Ag donor cells that regulates cross-priming of CD8+ T cells during primary sterile necrosis and thereby controls adaptive immune responses. We found that the cellular peptidases dipeptidyl peptidase 3 (DPP-3) and thimet oligopeptidase 1 (TOP-1), both of which are present in nonimmunogenic necrotic cells, eliminated proteasomal degradation products and blocked Ag cross-presentation. While sterile necrotic tumor cells failed to induce CD8+ T cell responses, their nonimmunogenicity could be reversed in vitro and in vivo by inactivation of DPP-3 and TOP-1. These results indicate that control of cross-priming and thereby immunogenicity of primary sterile necrosis relies on proteasome-dependent oligopeptide generation and functional status of peptidases in Ag donor cells.
CLINICAL LECTURE on CASES of PERITYPHLITIC ABSCESS of CAeCAL ORIGIN: Delivered at the Manchester Royal Infirmary
Authors: F. A. Southam
Journal: BMJ (1898)

Queen's Hospital on September 218t, I896, unAer the care of Dr. Foxwell (by whom he was subsequently transfet red to my care), having been sent in as a case of typhoid fever.About ten years ago he fell down and hurt his head, and subsequently had a discharge from the right ear, which, with short periods of intermission, had continued to the present time.He was able to work until a month ago; then the discharge became more profuse, and he suffered from pain in the frontal region at night.He remained in bed, but became worse.There had not been any vomiting, but there was a history from the friends of several fits and two rigors.Ten days ago a painful swelling was noticed below the right ear, which inereased and became more painful.There was a foul discharge from the right ear.The temperature was 1030, pulse 84; tongue very foul, a'nd coveredwith thick white fur; knee-jerks absent, no paralysis; double optic neuritis.On the 24th fluctuations were detected in the swelling in the neck, and he was seen by me on the 25th.An incision was at once made, and some ounces of very foul pus evacuated.for two days after this he was more comfortable, but his temperature kept high, and on the 27th he had a rigor, his temperature rising to 105 20.Although there was no recur- rence of the rigors he kept in an unsatisfactory condition, temperature varying from 980 to I050, pulse from 70 to I00.On October 2nd the abscess cavity was explored with a view of ligaturing and removing, if necessary, the right internal jugular vein, but no trace of it could be found, and I concluded that it had been destroyed by the suppuration His subsequent condition became more unsatisfactory, and it was deemed advisable to explore further.He was therefore trephined on October 14th.over the right temporo-pphenoidal lobe, and both this -and the cerebellum carefully explored with a needle.No abscess cavity was found.A crown of bone was then removed to open both the mastoid antrum and lateral sinus; the former contained a small quantity of caseous pus, the latter a blood clot The opening was packed with iodoform gauze.There was little change in the patient's condition after the -Operation; if anything he was more irritable and restless, and he refused food.There was no further vomiting.He gradually sank, and died on the night of the z5th.Po8t-mortem no trace of the right internal jugular vein could be found.The lateral sinus was thrombosed with blood clot, which had not become organised.In the white matter of the brain there were eight small abscesses found, evidently secondary; none elsewhere.
Rehabilitation After Cardiac Surgery-Reply
Authors: Alfred A. Rimm
Journal: JAMA (1976)

We appreciate the thoughtful comments of Drs Fisch and McGuire. We agree with Dr Fisch that factors other than those studied in our article could affect retirement status and changes in occupation. It is not clear, however, to what extent such changes may have contributed to the claims of reduced angina following the aortocoronary bypass operation.  We question whether the change to lighter work and the placebo effect are the two factors explaining the improvement in angina following surgery. Objective clinical measurements 1,2 using presurgical and postsurgical treadmill testing has shown that the bypass procedure does, in fact, reduce or eliminate anginal symptoms. In some marginal cases, however, it may be possible that a reduction of physical exertion may be a way of avoiding the anginal attack.  The question of incapacitation and working ability is an interesting one and deserves more study. In the case of ischemic heart
Near-tetraploid acute myeloid leukemias: an EGIL retrospective study of 25 cases
Authors: M-C Béné, G Castoldi, A Derolf, R Garand, T Haas, T Haferlach, W Knapp, E Kuhlein, P Lemež, W-D Ludwig, I Marinov, E Matutes, K Michalová, A Porwit-MacDonald, A Orfao, C Schoch, P Talmant, M B van't Veer, Z Zemanová, M Zühlsdorf
Journal: Leukemia (2006)
487 THE INTERMEDIATE FILAMENT PROTEIN SYNCOILIN MEDIATES INTRACELLULAR CALCIUM INCREASE IN MOUSE HEPATIC STELLATE CELLS
Authors: E. Van Rossen, Z. Liu, L.A. van Grunsven, J. Van der Straeten, J. Van Daele, T. Roskams, J.-P. Timmermans, H. Reynaert, A. Geerts
Journal: Journal of Hepatology (2008)