Sickle Cell Trait, Refractory Anemia, and Nutritional Anemia with Variable Expression of A and S Hemoglobin
Authors: HARVEY E. GRODE
Journal: Annals of Internal Medicine (1966)

Case Studies1 August 1966Sickle Cell Trait, Refractory Anemia, and Nutritional Anemia with Variable Expression of A and S HemoglobinHARVEY E. GRODE, M.D., JOHN LASZLO, M.D.HARVEY E. GRODE, M.D.Search for more papers by this author, JOHN LASZLO, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-2-321 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA patient is reported with sickle trait, refractory anemia, and nutritional anemia, whose red cells were found to alter the percentage of A and S hemoglobin by nongenetic factors. While it is unusual but not surprising to discover a patient with this combination of anemias, it is remarkable to find a concomitant alteration in hemoglobin expression.A clinical summary on this patient is presented and possible mechanisms discussed.CASE SUMMARYV.A.H. 4805, a 40-year-old Negro handyman, had a pertinent medical history dating back to July, 1950, when he consulted a physician because of dizziness, weakness, throbbing headache, and vomiting. At...References1. MYERSONHARRISONLOHMULLER RMEHW: Incidence and significance of abnormal hemoglobins. Amer. J. Med. 26: 543, 1959. CrossrefMedlineGoogle Scholar2. HARRIS JW: Red Cell. Harvard University Press, Cambridge, 1963, p. 340. Google Scholar3. HAVARD CW: Investigation of refractory anaemias. Quart. J. Med. 31: 21, 1962. MedlineGoogle Scholar4. HEATONCROSBYCOHEN LVWHA: Splenectomy and the treatment of hypoplasia of the bone marrow, with a report of 12 cases. Ann. Surg. 146: 637, 1957. CrossrefMedlineGoogle Scholar5. 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New Eng. J. Med. 271: 541, 1964. CrossrefMedlineGoogle Scholar28. COLOMBOBAGLIONI BC: Regulation of hemoglobin synthesis at the polysome level. J. Molec. Biol. 16: 51, 1966. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: HARVEY E. GRODE, M.D.; JOHN LASZLO, M.D.Affiliations: Durham, North CarolinaFrom the Duke University Medical Center and the Section of Hematology, Veterans Administration Hospital, Durham, N. C.This study was supported in part by grant CA 05634-05, the National Institutes of Health, Bethesda, Md.Dr. Grode is a Clinical Fellow in Hematology at the Duke University Medical Center, supported by grant T4 CA-5042, the National Institutes of Health, Bethesda, Md.Requests for reprints should be addressed to John Laszlo, M.D., Chief, Hematology Section, Veterans Administration Hospital, Durham, N. C. 27705. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe synthesis of abnormal haemoglobinsInherited disorders of hemoglobin synthesis and pregnancySickle-Cell Trait 1 August 1966Volume 65, Issue 2Page: 321-325KeywordsAnemiaGeneticsHeadachesHematology and oncologyHemoglobinHemolytic anemiaMegaloblastic anemiaNutritionVeteran careVomiting ePublished: 1 December 2008 Issue Published: 1 August 1966 PDF downloadLoading ...