tbuckley/cabot-search huggingface dataset:
Nitric oxide synthase (NOS) inhibition for one week improves renal sodium and water excretion in cirrhotic rats with ascites.
Authors: P Y Martin, M Ohara, P Gines, D L Xu, J St John, M Niederberger, R W Schrier
Journal: Journal of Clinical Investigation (1998)

Normalization of the increased vascular nitric oxide (NO) generation with low doses of NG-nitro-L-arginine methyl ester (L-NAME) corrects the hemodynamic abnormalities of cirrhotic rats with ascites. We have undertaken this study to investigate the effect of the normalization of vascular NO production, as estimated by aortic cyclic guanosine monophosphate (cGMP) concentration and endothelial nitric oxide synthase (eNOS) protein expression in the aorta and mesenteric artery, on sodium and water excretion. Rats with carbon tetrachloride-induced cirrhosis and ascites were investigated using balance studies. The cirrhotic rats were separated into two groups, one receiving 0.5 mg/kg per day of L-NAME (CIR-NAME) during 7 d, whereas the other group (CIR) was administrated the same volume of vehicle. Two other groups of rats were used as controls, one group treated with L-NAME and another group receiving the same volume of vehicle. Sodium and water excretion was measured on days 0 and 7. On day 8, blood samples were collected for electrolyte and hormone measurements, and aorta and mesenteric arteries were harvested for cGMP determination and nitric oxide synthase (NOS) immunoblotting. Aortic cGMP and eNOS protein expression in the aorta and mesenteric artery were increased in CIR as compared with CIR-NAME. Both cirrhotic groups had a similar decrease in sodium excretion on day 0 (0.7 versus 0.6 mmol per day, NS) and a positive sodium balance (+0.9 versus +1.2 mmol per day, NS). On day 7, CIR-NAME rats had an increase in sodium excretion as compared with the CIR rats (sodium excretion: 2.4 versus 0.7 mmol per day, P < 0.001) and a negative sodium balance (-0.5 versus +0.8 mmol per day, P < 0.001). The excretion of a water load was also increased after L-NAME administration (from 28+/-5% to 65+/-7, P < 0.05). Plasma renin activity, aldosterone and arginine vasopressin were also significantly decreased in the CIR-NAME, as compared with the CIR rats. The results thus indicate that normalization of aortic cGMP and eNOS protein expression in vascular tissue is associated with increased sodium and water excretion in cirrhotic rats with ascites.
Development of a Tongue-Piercing Method for Use With Assistive Technology
Authors: Julia S. Minocha, Jaimee S. Holbrook, Dennis P. West, Maysam Ghovanloo, Anne E. Laumann
Journal: JAMA Dermatology (2013)

Study limitations include the small number of participants, the exclusion of those with chronic conditions that might have delayed wound healing, and the variability of tongue thickness measurements because dimensions changed depending on the position and degree of tongue protrusion.In conclusion, a medic ally appropriate tonguepiercing protocol was developed.It was used to place a magnet-containing barbell that effectively operated the TDS.
Obesity and Asthma
Authors: David A. Beuther, Scott T. Weiss, E. Rand Sutherland
Journal: American Journal of Respiratory and Critical Care Medicine (2006)

Section:ChooseTop of pageAbstract <<OBESITY, AIRWAY INFLAMMAT...EPIDEMIOLOGIC OBSERVATION...OBESITY AND PULMONARY PHY...THE INFLUENCE OF SEX HORM...CONCLUSIONSReferencesCITING ARTICLES
A Loose Standard of Measurement.
Authors: J. L. Tracy
Journal: JAMA (1904)

Toledo, Ohio, Sept. 3, 1904. <h3>To the Editor:</h3> —InThe Journalfor September 4 a writer says that a tumor was "about the size of the distal phalanx of an adult finger," and in the next paragraph he says a gland was "about the size of a marrowfat pea." I presume in the first instance that he refers to the finger as you see it, and not to the bone, because in somewhat awkward English he seems to say that the tumor was 5 cm. in length and 3½ cm. in breadth. It is quite likely that when boys the most of us helped to grow peas, but it is just as likely that the physician who now refers you to a marrowfat pea does so from boyhood memory, and for the last twenty years has not been able to tell one variety of pea from another. "Two feet—the length
CD24 is a marker of exosomes secreted into urine and amniotic fluid
Authors: S. Keller, C. Rupp, A. Stoeck, S. Runz, M. Fogel, S. Lugert, H.-D. Hager, M.S. Abdel-Bakky, P. Gutwein, P. Altevogt
Journal: Kidney International (2007)
Epitope mapping of type VII collagen. Identification of discrete peptide sequences recognized by sera from patients with acquired epidermolysis bullosa.
Authors: J C Lapiere, D T Woodley, M G Parente, T Iwasaki, K C Wynn, A M Christiano, J Uitto
Journal: Journal of Clinical Investigation (1993)

Epidermolysis bullosa acquisita (EBA) is an acquired blistering skin disease characterized by the presence of IgG autoantibodies that recognize type VII (anchoring fibril) collagen. In this study, we have mapped the antigenic epitopes within the type VII collagen alpha chain by Western immunoblotting analysis with sera from 19 patients with EBA, using bacterial collagenase- or pepsin-resistant portions of type VII collagen and a panel of 12 recombinant fusion proteins corresponding to approximately 80% of the primary sequence of the alpha 1 (VII) collagen polypeptide. These studies identified four major immunodominant epitopes localized within the amino-terminal, noncollagenous (NC-1) domain. In addition to EBA, sera from three patients with bullous systemic lupus erythematosus (BSLE) were tested. The pattern of epitopes recognized by these sera were similar to those noted with EBA, suggesting that the same epitopes could serve as autoantigens in both blistering conditions. In contrast, sera from healthy controls or from patients with unrelated blistering skin diseases did not react with type VII collagen epitopes. Collectively, the results indicate that the immunodominant epitopes in EBA and BSLE lie within the noncollagenous regions of type VII collagen. The precise role of the circulating autoantibodies in the pathogenesis of these blistering diseases remains to be elucidated. Conceivably, however, such antibodies could disrupt the assembly of type VII collagen into anchoring fibrils and/or interfere with their interactions with other extracellular matrix molecules within the cutaneous basement membrane zone.
Composite Outcomes in Cardiovascular Research: A Survey of Randomized Trials
Authors: Eric Lim, Adam Brown, Adel Helmy, Shafi Mussa, Douglas G. Altman
Journal: Annals of Internal Medicine (2008)

Composite end points are common in clinical trials.To describe how composite outcomes are used, constructed, and reported in cardiovascular trials and to evaluate the contribution of individual end points to the composite estimate of effect in those trials.Review of 2-group, parallel-design, randomized cardiovascular trials that used composite end points and were published in 14 clinical journals from 1 January 2000 to 1 January 2007.Published randomized trials in cardiovascular medicine and surgery.Two-group, parallel-design trials published in 14 leading general medical, cardiology, and cardiothoracic surgery journals from 1 January 2000 to 1 January 2007.The types and numbers of individual events included in the composite outcome and P values and risk estimates for the composite outcome.Of 304 trials published that used composite outcomes, 221 (73%) reported a composite primary outcome and 83 (27%) reported a composite secondary outcome. Composite outcomes comprised a median of 3 (interquartile range, 3 to 4) individual outcomes; death was the most common individual outcome. The total number of individual events and the total number of events represented by the composite outcome differed in 79% of trials. P values for composite outcomes were less than 0.050 more frequently than they were 0.050 or greater. Death as an individual end point made a relatively minimal contribution to estimates of effect summarized by the trials' composite end points, whereas revascularization made a greater contribution.All-cause and cardiovascular mortality were not distinguished, and the findings might not apply to trials in other fields.Composite outcomes in cardiovascular trials are frequent and commonly comprise 3 to 4 individual end points that vary in clinical significance. Discrepancies between the total number of individual events in a trial and those reported for composite outcomes are common. Individual outcomes do not contribute equally to composite measures, so the overall estimate of effect for a composite measure cannot be assumed to apply equally to each of its individual outcomes.
Characterization of an Orbital Melanoma and Mucosa Associated Lymphoid Tissue (MALT) Lymphoma by Dual Phase N-Isopropyl-p-I-123 Iodoamphetamine
Authors: Mana Yoshimura, Soichi Akata, Kazuhiro Saito, Hiroaki Shindo, Jinho Park, Hedeji Hirose, Kiyoshi Koizumi, Hiroshi Goto
Journal: Clinical Nuclear Medicine (2007)

Usefulness of N-isopropyl-p-I-123 iodoamphetamine (I-123 IMP) for the detection of malignant melanoma and malignant lymphoma is well known.1–7 The appropriate interval from administration until image acquisition is unusual because the accumulation mechanism is different. We present a case of choroidal melanoma of the right orbit with a history of low-grade mucosa-associated lymphoid tissue lymphoma of the left lacrimal gland. She was followed with magnetic resonance imaging and dual phase I-123 IMP imaging 3 times. Viability of the melanoma was estimated by I-123 IMP delayed image obtained 24 hours after intravenous injection. In spite of cryosurgery twice, the accumulation of the tracer remained unchanged. Subsequent tumor excision proved the lesion to be a viable malignant melanoma. On the other hand, posttherapeutic mucosa-associated lymphoid tissue lymphoma of the left lacrimal gland was followed by the early image obtained 20 minutes after radionuclide injection. The accumulation increased gradually and the recurrence was pointed out. In the same way, magnetic resonance imaging examination was undertaken 3 times. Both lesions were obvious, but the findings were entirely unchanged in each examination.
Foundation is helping carers to reduce risk of sudden infant death syndrome
Authors: A. Deri-Bowen
Journal: BMJ (2001)

EDITOR—Gottlieb reports that more cases of the sudden infant death syndrome (cot deaths) occur in day care than at home.1 Since 1996 the Foundation for the Study of Infant Deaths has recognised that carers have been a neglected group for receiving advice on reducing the risk of the syndrome, information about cot deaths, and bereavement support.

The foundation has …
Should Patients With Zoster Receive Zoster Immune Globulin?
Authors: Sayenna A. Uduman
Journal: JAMA (1975)

Zoster developed in 55 patients, and in 15, generalized disease occurred. Twelve of 14 patients with dissemination had prompt appearance of both complement-fixing (CF) antibody and fluorescent antibody against varicella-zoster (VZ) membrane antigen (FAMA). The geometric mean titers of VZ antibody from the first to the fifth and the sixth through the tenth days following onset of zoster were similar in patients with localized and generalized involvement. Two patients with disseminated zoster had undetectable CF antibody, but VZ FAMA was demonstrable. Because the clinical course of zoster appears to be unrelated to the serologic response to VZ virus, it is unlikely that administration of antibody to patients with zoster would be of benefit in this disease. (<i>JAMA</i>234:1049-1051, 1975)
Clues to the Pathogenesis of Bleeding in von Willebrand's Disease
Authors: Oscar D. Ratnoff, Bruce Bennett
Journal: New England Journal of Medicine (1973)

RECENT studies have demonstrated that the plasma of patients with classic hemophilia, deficient in functional antihemophilic factor (AHF), contains normal or elevated amounts of antigenic material related to AHF.1 2 3 4 In patients with classic hemophilia, the bleeding time is normal, and when whole blood is filtered through glass beads, a normal proportion of platelets is retained. In contrast, the plasma of patients with von Willebrand's disease is deficient both in functional AHF activity and in antigens related to AHF.3 , 4 In most patients with von Willebrand's disease, the bleeding time is prolonged, and platelet retention by columns of glass beads is deficient. . . .
Methane Found in Well Water Near Fracking Sites
Authors: David C. Holzman
Journal: Environmental Health Perspectives (2011)

Quality Management District announced the launch of a two-year study on the Burlington Northern Santa Fe railyard in San Bernardino, a major transportation hub for the Los Angeles -Long Beach port complex.The study, to be conducted by Loma Linda University, will examine respiratory diseases and cancer among 1,200 children and adults in communities surrounding the railyard.A 2008 California Air Resources Board health risk assessment suggested the San Bernardino facility had the worst health impact on surrounding communities of any railyard in California. 6
Rewarding Provider Performance: Aligning Incentives in Medicare
Authors: Woodruff J. English
Journal: Annals of Internal Medicine (2008)

Medical Writings: Book Notes15 April 2008Rewarding Provider Performance: Aligning Incentives in MedicareWoodruff J. English, MDWoodruff J. English, MDFrom Providence St. Vincent Medical Center, Portland, Oregon.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-148-8-200804150-00028 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Rewarding Provider Performance: Aligning Incentives in MedicareInstitute of Medicine. 272 pages. Washington, DC: National Academies Pr; 2007. $39.56. ISBN 9780309102162. Order at www.nap.edu.Field of medicine: Health system management.Format: Hardcover book.Audience: Strategic planners and medical group leaders.Purpose: To offer strategies for improving health care.Content: This book explores how changing Medicare payments could drive system improvements to achieve more desirable results in clinical quality, patient-centered care, and efficiency. We deliver extraordinarily good care in a broken system that does not live up to our expectations. It is plagued by medical errors of omission and commission, widespread ... Author, Article, and Disclosure InformationAffiliations: From Providence St. Vincent Medical Center, Portland, Oregon. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByMeasuring Burden of Care After Catastrophic Illness or InjuryNon-accidental trauma increases length of stay and mortality in pediatric trauma 15 April 2008Volume 148, Issue 8Page: 636KeywordsForecastingGamesHealth careHealth care qualityMedical servicesMedicareMotivationPrevention, policy, and public healthQuality improvementSoftware tools ePublished: 15 April 2008 Issue Published: 15 April 2008 CopyrightCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Adrenomedullin: expression and possible role in human skin and hair growth
Authors: F.B. Muller, S. Muller-Rover, B.P. Korge, S. Kapas, J.P. Hinson, M.P. Philpott
Journal: British Journal of Dermatology (2003)

Journal Article Adrenomedullin: expression and possible role in human skin and hair growth Get access F.B. Müller, F.B. Müller Department of Dermatology, University of Cologne, Cologne, GermanyCentre for Cutaneous Research, Clinical Sciences Research Centre, St Bartholomew's and The Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, 2 Newark Street, London E1 2AT, U.K Search for other works by this author on: Oxford Academic Google Scholar S. Müller‐Röver, S. Müller‐Röver Centre for Cutaneous Research, Clinical Sciences Research Centre, St Bartholomew's and The Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, 2 Newark Street, London E1 2AT, U.KDepartment of Dermatology, University Hospital Eppendorf, Hamburg, Germany Search for other works by this author on: Oxford Academic Google Scholar B.P. Korge, B.P. Korge Department of Dermatology, University of Cologne, Cologne, Germany Search for other works by this author on: Oxford Academic Google Scholar S. Kapas, S. Kapas Centre for Cutaneous Research, Clinical Sciences Research Centre, St Bartholomew's and The Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, 2 Newark Street, London E1 2AT, U.K Search for other works by this author on: Oxford Academic Google Scholar J.P. Hinson, J.P. Hinson Centre for Cutaneous Research, Clinical Sciences Research Centre, St Bartholomew's and The Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, 2 Newark Street, London E1 2AT, U.K Search for other works by this author on: Oxford Academic Google Scholar M.P. Philpott M.P. Philpott Centre for Cutaneous Research, Clinical Sciences Research Centre, St Bartholomew's and The Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, 2 Newark Street, London E1 2AT, U.K Michael P.Philpott. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 148, Issue 1, 1 January 2003, Pages 30–38, https://doi.org/10.1046/j.1365-2133.2003.05016.x Published: 01 January 2003 Article history Accepted: 30 May 2002 Published: 01 January 2003
Recurrence Rates of Genital Herpes
Authors: Lewis Marshall
Journal: Annals of Internal Medicine (1995)

Letters1 June 1995Recurrence Rates of Genital HerpesLewis Marshall and Peter PurnellLewis MarshallSearch for more papers by this author and Peter PurnellSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-122-11-199506010-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In the study by Benedetti and colleagues [1], patients had an unusually low seroprevalence of 13% for herpes simplex virus type 1 (HSV-1) infection. Other authors have reported a seroprevalence ranging from 35% to 60% in the white U.S. population [2, 3]. Previous exposure to HSV-1 favorably influences subsequent morbidity from HSV-2 infection [4] as shown in this study. The high recurrence rates and severe disease in this group may reflect this low rate of previous exposure to HSV-1 and thus are not necessarily applicable to all patients infected with HSV-2. For this reason, we feel that ...References1. Benedetti J, Corey L, Ashley R. Recurrence rates in genital herpes after symptomatic first-episode infection. Ann Intern Med. 1994; 121:847-54. Google Scholar2. Corey L. Herpes simplex virus infections during the decade since the licensure of acyclovir. J Med Virol Suppl. 1993; 1:7-12. Google Scholar3. Nahmias AJ, Lee FK, Beckman-Nahmias S. Seroepidemiological and sociological patterns of herpes simplex virus infection in the world. Scand J Infect Dis Suppl. 1990; 69:19-36. Google Scholar4. Holmes K, ed. Sexually Transmitted Diseases. 2d ed. New York: McGraw-Hill; 1990:397. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1995Volume 122, Issue 11Page: 883KeywordsGenital anatomyHerpes simplexInfectious diseasesMorbidityPatients Issue Published: 1 June 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Assessment of Blood Flow Distal to Coronary Artery Stenoses
Authors: D. Douglas Miller, Thomas J. Donohue, Thomas L. Wolford, Morton J. Kern, Steven R. Bergmann, Carol M. Mechem, Judy J. Hartman
Journal: Circulation (1996)

Background Previous studies have correlated quantitative coronary angiographic stenosis severity with positron emission tomography (PET) myocardial perfusion and proximal measurements of intracoronary flow velocities in normal and diseased coronary arteries. The aim of this study was to correlate regional myocardial blood flow (RMBF) derived from [ 15 O]H 2 O PET with directly measured poststenotic intracoronary Doppler flow velocity data acquired under basal conditions and dipyridamole-induced hyperemia. Methods and Results Eleven consecutive patients 53±13 years old with ischemic chest pain and isolated proximal left coronary artery stenoses (left anterior descending, 9; left circumflex, 2; mean, 59±23% diameter stenosis) underwent [ 15 O]H 2 O myocardial PET and intracoronary Doppler flow velocity studies within 1 week. PET RMBF (mL·g −1 ·min −1 ) and myocardial perfusion reserve (MPR) were calculated in poststenotic and normal reference vascular beds. Poststenotic Doppler average peak flow velocities (APV; cm/s) and coronary flow velocity reserve (CFR) were compared with corresponding PET data and quantitative angiographic lesional parameters. PET RMBF and Doppler APV were linearly correlated ( r =.60; P &lt;.001), as were poststenotic PET MPR and Doppler CFR ( r =.76; P &lt;.0002). Relative coronary flow velocity and MPR ratios between poststenotic and angiographically normal vascular beds were comparably reduced (0.83±0.25 versus 0.86±0.21, respectively; P =NS). Conclusions Intracoronary Doppler flow velocities acquired distal to isolated left coronary artery stenoses correlated with [ 15 O]H 2 O PET regional myocardial perfusion and are useful for assessment of the physiological significance of coronary stenoses in humans.
Notes on Prevention of Tetanus in Injured Persons
Authors: H. J. Parish, L. J. M. Laurent, N. H. Moynihan
Journal: BMJ (1957)

The need for these notes was brought home to us by several requests for guidance from surgeons, casualty officers, and others.We do not consider the decision concerning which injuries require tetanus prevention falls within the scope of this paper,* but when, after clinical assessment of the injury, it has been decided that there is a risk of tetanus infection and that suitable preventive measures should therefore be taken, it is suggested that the following procedures should be adopted. Suggested ProceduresDetermination of Immunity Status.-Inquiryshould be made into the possibility of previous tetanus toxoid admini- stration, in order to determine whether the patient is non- immune or actively immune. (A difficulty may arise in taking the patient's history, as he may confuse previous injections of serum or various prophylactics with injections of tetanus toxoid.)
Development of Garrod's pads in the fingers of a professional violinist.
Authors: H A Bird
Journal: Annals of the Rheumatic Diseases (1987)

Garrod's pads, thickening of the skin and underlying tissues over the interphalangeal joints that can mimic Heberden's and Bouchard's nodes, are thought to be occupational in aetiology and to arise from mechanical factors.In some professional musicians, particularly string players, the functions of the two hands differ markedly.The findings of Garrod's pads isolated to the proximal interphalangeal joints on the middle and index fingers of the left hand in a professional violinist provides an insight into the mechanical factors most likely to produce them.
On the origins of complexity
Authors: Bruce E. Hesse, Gary Novak
Journal: Behavioral and Brain Sciences (2001)

Darwin's theory of natural selection is as applicable to the analysis of the behavior of organisms as it is to their origins. Skinner's theoretical writings have guided operant psychologists in this area. The behavioral account of selection by Donahoe and Palmer (1994) is positively compared to the points on operant selection made by Hull et al. The “general account of selection” was found to be useful.
Detection of Urinary Extravasation by Delayed Technetium-99m DTPA Renal Imaging
Authors: JUNICHI TAKI, NORIHISA TONAMI, TAMIO ABURANO, KINICHI HISADA
Journal: Clinical Nuclear Medicine (1986)

Delayed imaging with Tc-99m DTPA renal scintigraphy demonstrated urinary extravasation in a patient with acute anuria in whom early sequential imaging showed no abnormal extrarenal radionuclide accumulation.