tbuckley/cabot-search huggingface dataset:
712 PNPLA 3 RS738409 GG HOMOZYGOTE STATUS IS ASSOCIATED WITH INCREASED RISK OF HEPATOCELLULAR CARCINOMA IN CIRRHOTIC PATIENTS
Authors: S. Hamza, J.M. Petit, D. Masson, V. Jooste, C. Binquet, C. Sgro, B. Guiu, J.P. Bronowicki, G. Thieffin, V. Di Martino, M. Doffoel, H. Barraud, C. Richou, J.L. Jouve, J.J. Raab, A.M. Bouvier, V. Cottet, B. Verges, A. Minello, C. Bonithon Kopp, P. Hillon
Journal: Journal of Hepatology (2012)
Particles in spleens.
Authors: M Tavassoli, R J Ratzan
Journal: BMJ (1972)

54 patients with localized or primary malignant melanoma had circulating cytoplasmic antibody.A few patients formerly positive but who had converted to negative, and some who on clinical grounds had a primary lesion but who had negative tests for cytoplasmic antibody, were found to have developed metastatic lesions.It is postulated that the halo naevus represents a seldom seen interim stage natural protective mechanism-that is, a rejection phenomenon of malignant melanoma.It is the visualization, so to speak, of the sur- veillance system normally so effective in pre- venting malignant melanoma from developing in every individual.The study of such aspects in the behaviour of moles and melanomas raises the question not only why are halo naevi spontaneously rejected and heal, but why do malignant melanomas de- velop and persist in patients who in all other respects appear to have normal and intact immunological mechanisms.-Weare, etc.,
Abstract 340: Predictive value of KRAS mutations in advanced non-small cell lung cancer (NSCLC) patients (pts) treated with chemotherapy (CT)
Authors: Anne-Marie C. Dingemans, Egbert F. Smit, Jules Derks, Wouter Mellema, Danielle Heideman, Robertjan Van Suylen, Erik Thunnissen
Journal: Cancer Research (2011)

Abstract Introduction: KRAS mutation is thought to be related with poor outcome of NSCLC pts. The predictive value of KRAS mutation for response to chemotherapy (CT) has not been established Patients and methods: From a retrospective database from 2 university hospitals all pts with advanced NSCLC treated with palliative platinum containing chemotherapy were selected. Pts were included when archive tumor tissue was available for DNA extraction. High resolution melting followed by PCR sequencing was performed for KRAS exon1 and 2. Results: KRAS mutation analysis was evaluable for 122 pts. All pts had advanced NSCLC and were no candidate for treatment with curative intent. Mean age 61 years (range 24-80 years), 81 males and 41 females. All pts received platinum-containing CT. Response was evaluable for 110 pts: 1 complete response, 21 partial response, 54 stable disease and 54 progressive disease. Median progression free survival (PFS) was 5.7 months (m) (95% CI 4.2-7.2 m), median overall survival (OS) was 7.5 m (94% CI 5.2-9.9 m). 44 pts (36%) had a KRAS mutation. 38% of pts with a KRAS mutation had as best response PD on CT, and 27% of pts without a KRAS mutation had PD, this difference was not significant. No difference in PFS and OS was observed for pts with a KRAS mutation (median PFS 5.3 m, 95% CI 3.2-7.3 m and median OS 6.2 m, 95% CI 4.8-7.3 m) and without a KRAS mutation (median PFS 6.1, 95% CI 5.0-7.2m and median OS 8.9 m, 95% CI 6.4-11.4). Conclusion: In our series KRAS mutation was not predictive for response to platinum containing CT in pts with advanced NSCLC. Furthermore, KRAS mutation was not prognostic. Additional data on specific KRAS mutations will be presented. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 340. doi:10.1158/1538-7445.AM2011-340
Liver Function in Patients with Elevated Serum Cholesterol or Low-Density Lipoproteins
Authors: H. ENGELBERG
Journal: Circulation (1960)

Liver function tests were performed in 42 individuals with increased levels of serum cholesterol and low-density lipoproteins. The tests were normal in 39 patients; the sulfobromophthalein excretion was impaired in 3. These results indicate that disturbances in liver function are not usually involved in elevations of serum triglycerides. Other clinical evidence is discussed which suggests that the heparin lipoprotein-lipase lipolytic mechanism, but not the liver or reticuloendothelial system, occupies the initial role in the removal of alimentary fat from the bloodstream in man.
Sterility and Artificial Insemination
Authors: M. M. White
Journal: BMJ (1943)

Takotsubo cardiomyopathy is a transient left-ventricular dysfunction that typically occurs in elderly women due to emotional or physical stress. An 85-y-old woman underwent flexible bronchoscopy to evaluate her malignant lymphoma. After flexible bronchoscopy, she experienced takotsubo cardiomyopathy diagnosed by left ventriculography and subsequent generalized tonic-clonic seizure diagnosed by electroencephalography. Magnetic resonance imaging of her brain after 1 d showed post-convulsive encephalopathy. We believe that these 2 consecutive incidents were caused by the physical stress of the flexible bronchoscopy.
Dust-mite-allergen concentrations in asthmatics' bedrooms in the Quad Cities (Illinois, USA) after the Mississippi River floods of 1993
Authors: L. Curtis, M. Ross, P. Scheff, V. Persky, R. Wadden, V. Ramakrishnan, D. Hryhorczuk
Journal: Allergy (1997)

This study aimed to measure allergens from Dermatophagoides farinae and D. pteronyssinus and to examine possible relationships of these mite allergens with flooding and other housing factors. A total of 313 dust samples were collected from the bedrooms of 57 asthmatics in 45 homes in the Quad Cities (Illinois, USA) and analyzed by ELISA for the presence of the D. farinae and D. pteronyssinus allergens. Twenty of these homes had some flooding in the last 12 months due to the Mississippi River floods of 1993 and/or other factors. The log‐transformed least‐squares means of allergens collected were 28 ng/m 2 for the D. farinae allergen and 26 ng/m 2 for the D. pteronyssinus allergen. D. farinae allergen levels were significantly higher in homes located in the valley, in homes during the summer months, in homes with furred or feathered pets, in homes which had not been flooded in the last year, and in homes where rugs had been steam‐cleaned in the last 12 months. D. pteronyssinus allergen levels were significantly higher in homes located in the valley, in homes during April and July‐September, in homes with furred or feathered pets, and in homes with no dehumidifier.
Differentiation of an Unclear Splenic Lesion in a Patient With Cholangiocarcinoma
Authors: Constantin Lapa, Ulrich Steger, Christian O. Ritter, Vanessa Wild, Ken Herrmann
Journal: Clinical Nuclear Medicine (2014)

Here we report on a 51-year-old man with the primary diagnosis of cholangiocarcinoma. Workup with CT and contrast-enhanced ultrasound revealed an additional lesion in the spleen, raising the concern for metastasis. Combined FDG PET/CT revealed a different metabolic pattern, making a metastasis unlikely. Histopathology of the splenic lesion confirmed sclerosing angiomatoid nodular transformation, a rare benign lesion of the spleen.
Atlas of Diagnostic Cytology
Authors: Tilde S. Kline
Journal: JAMA (1978)

<b>Aspiration Cytology of the Breast</b>(Volker Schnider, trans), by Hubert Schondorf, 141 pp, 92 illus, np, Philadelphia, Saunders, 1978. Two new books on cytology are available. One confines itself to a specialized procedure in a specific area—aspiration biopsy of the breast; the second is a text of general clinical cytology that describes both exfoliative cytology and aspiration biopsies. The<i>Atlas of Diagnostic Cytology</i>covers systemic cytology with an introductory chapter on the components of a cell as viewed by electron microscopy and a chapter on cytogenetics. Although this is a broad spectrum for a 227-page atlas, the author does a commendable job. The more than 350 color plates, although they measure only 6.1×3.8 cm, are beautifully clear. The photographs are chiefly of Papanicolaou preparations as well as a few illustrations of cells, air dried and stained by May-Grunwald-Giemsa, histochemical stains, and fluorescent stains. There are also some corresponding illustrations of
Prevention of Sea-sickness in Assault Craft
Authors: I. G. W. Hill, A. I. Guest
Journal: BMJ (1945)

over 650 cases of cutaneous sensitivity to sulphonamides have been seen in North Africa and Italy; of these, 500 are reported and classified into 16 various types.These reactions were due to the treatment of many different con- ditions, from major wounds and burns to slight grazes, impetigo, and chancroid.Only 3 of the types described are liable to cause a grave or prolonged illness-i.e., the pemphigoid, the suiphonamide-light eruption, and the sulphonamide contact dermatitis.Sulphonamide-light dermatitis accounted for 72.2%, and contact dermatitis and its complications for 17.2%-i.e., 90% of the total.Most cases of reaction were due to the use of sulphanilamide in powder form; the safest drugs appeared to be sulphadiazine and sulphaguanidine.Acriflavine can reactivate a sulphonamide-light or contact der- matitis just as may cocaine.No race is exempt from this sensitization-skin colour and texture make little or no difference.Sulphonamide reactions are uncommon in U.S. troops compared with British.The local application of sulphonamides is contraindicated in skin diseases, though there is little risk if the drugs are used with certain precautions.Intramuscular penicillin appears to be the treatment of choice in two types-the pemphigoid and the severe light dermatitis.
Patients with tuberculosis in rural India should receive food supplements during treatment, researchers say
Authors: S. Bagcchi
Journal: BMJ (2013)

Researchers have urged nutritional support for rural people in India during their treatment for pulmonary tuberculosis.1

In a retrospective study conducted at Jan Swasthya Sahyog—a non-profit voluntary organisation based in Chhattisgarh—Indian and Canadian researchers have found that undernutrition is a substantially prevalent comorbidity in India, increasing the risk of death in rural people with pulmonary tuberculosis. The study was published on 24 October in PLoS ONE .

The researchers assessed a consecutive cohort of 1695 patients living in rural areas in Chhattisgarh with pulmonary tuberculosis, during 2004-09. …
Correlation of Serum Creatinine Concentration and Gentamicin Half-Life
Authors: Ralph E. Cutler, Anne Marie Gyselynck, W. Patrick Fleet, Arden W. Forrey
Journal: JAMA (1972)

The serum half-life of gentamicin sulfate following an intravenous dose was compared to the serum creatinine concentration in 21 adult patients with different degrees of renal failure. A correlation was found such that the gentamicin half-life (in hours) could be estimated by multiplying the serum creatinine concentration (mg/100 ml) by four. The apparent distribution volume for gentamicin is about 24% of the body weight, but may be larger in patients with renal insufficiency. An injection of 2 mg/kg of body weight will result in therapeutic drug levels. Kinetic analysis predicts that repetition of this loading dose every third half-life will result in therapeutic, nontoxic serum levels in patients with renal failure. An alternate approach using a constant dose interval but varying the quantity of drug can be predicted from a nomogram.
IL-17F sequence variant (His161Arg) is associated with protection against asthma and antagonizes wild-type IL-17F activity
Authors: M KAWAGUCHI, D TAKAHASHI, N HIZAWA, S SUZUKI, S MATSUKURA, F KOKUBU, Y MAEDA, Y FUKUI, S KONNO, S HUANG
Journal: Journal of Allergy and Clinical Immunology (2006)
INTESTINAL TREATMENT OF TUBERCULOUS PERITONITIS.
Authors: HENRY T. BYFORD
Journal: JAMA (1899)

In his Principles and Practice of Medicine, Osler uses these words:  treatment of tubercular peritonitis has fallen largely into the hands of the surgeons. And after a long search among medical text-books I ceased to wonder at this, for I could get but little information on the medical treatment. Therefore the average practitioner who depends on his text-books would seem to have no way of learning how to treat it. He is taught to treat peritonitis by opium, rest, etc., and to send the case to the surgeon.  The fact that improvement takes place after an abdominal incison in cases of tubercular peritonitis, has led many surgeons to look on the procedure as a cure. If, however, we believe with von Winckel that five years should elapse before the patient is considered cured, and remember that only about 15 per cent. have been under observation more than two years
How frequently should basic cardiopulmonary resuscitation training be repeated to maintain adequate skills?
Authors: H J Berden, F F Willems, J M Hendrick, N H Pijls, J T Knape
Journal: BMJ (1993)

introduction of solids cannot be elicited from the data of Fergusson et al because they defined early feeding with solids as before 4 months of age, and details of feeding pattems in this time are not available.'5 16Continued follow up of our cohort may clarify this issue as the prevalence of eczema and other allergic disorders peaks in later childhood.26Fergusson et al have now followed up their study group for 10 years'6 and confirmed their earlier report, which associated early feeding with solids and eczema. 15his study has shown that, after data were adjusted for confounding variables, early feeding with solids is less harmful to the infant than previously indicated.Apart from a less than twofold increase in respiratory illness no other consistent adverse effects were detected during the first two years of life.Longer follow up is required, but, in the meantime, a more flexible approach to the introduction of solids should be considered, with advice being focused on the specific needs of individual mothers and infants.This work was funded by a
CASES SHOWING REMOTE RESULTS OF TESTICLE IMPLANTATION
Authors: G. FRANK LYDSTON
Journal: JAMA (1918)

As I exhibited the first of the patients to a number of the members of the American Urological Association, and both patients at the meetings of the Chicago Urological Association in October and November last, there will be no difficulty in verifying the findings given below. As the cases already have been reported in detail, I will give at this time only a brief outline: <h3>REPORT OF CASES</h3><h3>Case 1.</h3> —A man, aged 30, had completely lost both testicles from infection following trauma. There were moderately marked feminine secondary sex characteristics; excessive and feminine distribution of fat was especially noticeable. There was complete impotence, with decided mental and physical inefficiency. Double scrotal implantation of entire testicles was performed, Aug. 1, 1915. The material was taken from a boy of 14, killed by a crushing injury. The testes were removed six hours after death, and kept on ice for thirtythree hours.
Full-length HBV genome analysis of isolates from serum and liver of lamivudine-treated patients with different clinical outcome
Authors: Giovanni Cerenzia, Teresa Pollicino, Giovanni Squadrito, Santa Brancatelli, Carolina Boni, Vito DiMarco, Givanbattista Gaeta, Ruggero Panebianco, Giovanni Raimondo
Journal: Journal of Hepatology (2002)
The Role of Mediators of Cell Invasiveness, Motility, and Migration in the Pathogenesis of Silent Corticotroph Adenomas
Authors: Ozgur Mete, Caroline Hayhurst, Hussein Alahmadi, Eric Monsalves, Hasan Gucer, Fred Gentili, Shereen Ezzat, Sylvia L. Asa, Gelareh Zadeh
Journal: Endocrine Pathology (2013)
Juvenile hyaline fibromatosis and infantile systemic hyalinosis: A unifying term and a proposed grading system
Authors: Ahmad Nofal, Mohammad Sanad, Magda Assaf, Eman Nofal, Amani Nassar, Sahar Almokadem, Enayat Attwa, Khaled Elmosalamy
Journal: Journal of the American Academy of Dermatology (2009)
Hypertrophy of Ectopic Thyroid Remnant Following Adult Onset Hypothyroidism
Authors: ASEEM BHATNAGAR, MAHESMWAR SAHU, HARISM RAWAT
Journal: Clinical Nuclear Medicine (1997)

The authors report an unusual case of a menopausal woman developing a perihyoidal nodule subsequent to the onset of hypothyroidism. Tc-99m pertechnetate imaging showed intense uptake in the nodule and patchy nonuniform uptake in the normally located cervical thyroid gland. The authors presume that the nodule represents a dormant aberrant thyroid remnant, which underwent TSH-stimulated hypertrophy after autodestruction of the cervical thyroid gland.
CLINICAL PICTURE OF STREPTOCOCCIC OSTEOMYELITIS OF THE TEMPORAL BONE
Authors: HARRY BOYD-SNEE
Journal: JAMA (1923)

In what follows I have endeavored to present the clinical picture of a disease of the temporal bone which is to be recognized and diagnosticated as a clinical entity, and what I have to say on the subject will refer particularly to the disease as I have observed it to manifest itself in a large group of cases that I have encountered in military and civil practice. The period covers from November, 1917, to the present time. The group comprises altogether 285 persons. The fact that the disease was found on both sides in thirty-five made it possible to explore the region and authenticate the diagnosis in 320 instances. The ages of these patients varied from 6 months to 60 years. The findings in the examinations made of the material recovered and designated preoperative, operative and postmortem have been consistently characteristic in every case, and on the anatomicopathologic and the
The Clinical Use of Borocaine Borate and Beta-Eucaine Borate for Urethral Anaesthesia
Authors: R. Coyte
Journal: BMJ (1926)

Twm BAmu beinig 180 seconds.Conjunctival anaesthesia under boroe cain1e usually lasted well over five minutes with tlle 2 per cent.solution, and over ten minutes with the 4 per cent.solution.Witlh cocainie anaesthesia tlhe conjunctiva was al yays insensitive for at least five minutes..lftcr-effects.-Totest the after-effects the anaesthesia was iniduced with 5 per cent.cocaine and with 4 per cent.borocaine, and the eye was inspected the next day.Boiocaine was used in 31 cases and 16 returned.Cocaine was employed ini 31 cases and 18 returned.The accompaniying tables record the results, and so far as tley go poinit to cocaine, even in 5 per oent.solution, as being less harmiiful to the-corneal epitlielium than borocaine.Removal of a foreign body appears to be more likely to be comiplete in the case of cocaine than in that of borocaine.The effect tiponi the tension is slhown in Table III (soene of the cases.tested had glaucoma).It would appear that the effect of the two drugs is much the same, but borocdine appeared to cause a rise of tension in a greater nuumber of cases tlhani cocaine.TABLE I.-5 per cent.Cocaine.Stubjective C ndition of Con-Condition.junctival Vessels.Condition at Site of Removal.Irritable Injected Irregu'ar peeling of surface epithelium.Irritable Marked injection Ci:cumscribed ulceration.Irritable Marked injection Irregular peeling of superficial epi- thelium.Com-fortable No injection Area circumscribed; no staining with fluorescein.
Studies on cold insoluble globulin. I Concentrations in citrated plasma in rheumatic disorders.
Authors: O Fyrand, E Munthe, N O Solum
Journal: Annals of the Rheumatic Diseases (1978)

Cold insoluble globulin (CIG) is a normal glycoprotein of human serum and plasma. The physiological significance of this protein is unknown, but is shows a temperature-dependent relation to fibrinogen and fibrin. It is possible that it represents a substrate for activated fibrin-stabilising factor in the polymerisation of fibrin. CIG is found on the surface of fibroblasts. In the present study CIG was estimated in citrated plasma in 115 patients with rheumatic diseases. Increased amounts were found in patients with systemic lupus erythematosus, secondary amyloidosis in classical and definite rheumatoid arthritis, and in male patients with juvenile rheumatoid arthritis.
Intra‐arterial methylprednisolone for the management of steroid‐refractory acute gastrointestinal and hepatic graft versus host disease
Authors: Laurie A. Milner, Michael W. Becker, Steven H. Bernstein, Lauren Bruckner, Jonathan W. Friedberg, George A. Holland, J.J. Ifthikharuddin, Jane L. Liesveld, Edward J. Mathes, Heather L. Menchel, Craig A. Mullen, Talia Sasson, Gordon L. Phillips
Journal: American Journal of Hematology (2011)
European Commission drops health from services proposal in face of opposition
Authors: Rory Watson
Journal: BMJ (2005)

The health sector is to be excluded from draft European legislation designed to open up the market for services throughout the European Union's 25 member states. The European Commission in Brussels has decided to radically overhaul its original proposal because of wide ranging opposition to the plans it tabled last year to abolish national restrictions on service providers.

The abrupt U turn, announced last week by Charlie McCreevy, the internal market commissioner, has been welcomed by medical organisations and by the British government. They had always maintained that because of its unique nature, the health sector should not be covered by the new …
Schizophrenia and Violence: Systematic Review and Meta-Analysis
Authors: Seena Fazel, Gautam Gulati, Louise Linsell, John R. Geddes, Martin Grann
Journal: PLoS Medicine (2009)

Seena Fazel and colleagues investigate the association between schizophrenia and other psychoses and violence and violent offending, and show that the increased risk appears to be partly mediated by substance abuse comorbidity.
Diseases of the alimentary system. Haematemesis and melaena.
Authors: P B Cotton, R C Russell
Journal: BMJ (1977)

Acute gastrointestinal haemorrhage remains a common cause of emergency hospital admission, with a mortality close to 10OO despite recent improvements in resuscitation, anaesthesia, and surgery.'In Britain, most patients bleed from peptic ulcers or from erosions of the stomach or oesophagus.'The range of potential sources is large, however, and includes varices, tumours, mucosal tears, vascular malformations, and foreign bodies.The outlook for an individual patient depends upon the source of the bleeding, age, and the presence of co-existing disease.3We see few patients who bleed so copiously that on admission they need immediate surgery to prevent exsanguination.Most stop spontaneously, if only temporarily.This brief respite allows resuscitation, assessment, and the formation of a manage- ment plan, bearing in mind an overall chance of immediate rebleeding of around 200'.There is a delicate balance to be drawn between conservatism and aggression, in both diagnosis and treatment.Assessment
Electrospinning of chitin nanofibers: Degradation behavior and cellular response to normal human keratinocytes and fibroblasts
Authors: Hyung Kil Noh, Sung Won Lee, Jin-Man Kim, Ju-Eun Oh, Kyung-Hwa Kim, Chong-Pyoung Chung, Soon-Chul Choi, Won Ho Park, Byung-Moo Min
Journal: Biomaterials (2006)
Dismantling the signposts to public health? NHS data under the Health and Social Care Act 2012
Authors: A. M. Pollock, A. Macfarlane, S. Godden
Journal: BMJ (2012)

A shift away from area based populations in England will have severe implications for population health data, argue  Allyson M Pollock ,  Alison Macfarlane , and  Sylvia Godden