Intermittent Supraoptic-hypophyseal Diabetes Insipidus with Acquired Pitressin Resistance
Authors: LAURENCE H. KEDES
Journal: Annals of Internal Medicine (1964)

Case Studies1 December 1964Intermittent Supraoptic-hypophyseal Diabetes Insipidus with Acquired Pitressin ResistanceLAURENCE H. KEDES, M.D., JAMES V. BONESSI, M.D., T. S. DANOWSKI, M.D., F.A.C.P.LAURENCE H. KEDES, M.D.Search for more papers by this author, JAMES V. BONESSI, M.D.Search for more papers by this author, T. S. DANOWSKI, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-6-1128 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThis report describes an unusual instance of supraoptic-hypophyseal diabetes insipidus (SHDI) with documented complete spontaneous remissions that meets the criteria of an intermittent or incomplete disease state (1). In addition the patient also exhibited an acquired unresponsiveness to a commercial vasopressin preparation (Pitressin).REPORT OF CASET. L., a white male, developed polyuria and polydipsia at the age of 12 years. There was no family history of excessive water drinking and no preceding trauma or serious illness. Studies at Children's Hospital of Pittsburgh established that the specific gravity of the urine remained very low (1.001 to 1.006) despite water deprivation...References1. DANOWSKIMOSES TSC: Which camel: bactrian or dromedary (editorial). Diabetes 12: 84, 1963. CrossrefMedlineGoogle Scholar2. GROSSMANMINESGOLDMANWOLFMAN JMFAGM: Effects of calcium on urine concentrating ability. J. Clin. Invest. 37: 899, 1958. Google Scholar3. MANITIUSLEVITANBECKEPSTEIN AHDFH: On the mechanism of impairment of renal concentrating ability in hypercalcemia. J. Clin. Invest. 39: 693, 1960. CrossrefMedlineGoogle Scholar4. RELMANSCHWARTZ ASWB: The nephropathy of potassium depletion. New Eng. J. Med. 255: 195, 1956. CrossrefMedlineGoogle Scholar5. 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HOFERHINKLE MALE: Production of conditioned diuresis in man. J. Clin. Invest. 42: 1421, 1963. CrossrefMedlineGoogle Scholar18. HINKLEEDWARDSWOLF LECJS: The occurrence of diuresis in humans in stressful situations and its possible relation to the diuresis of early starvation. J. Clin. Invest. 30: 809, 1951. CrossrefMedlineGoogle Scholar19. MILESDEWARDENER BEHE: Effect of emotions on renal function in normotensive and hypertensive women. Lancet 2: 539, 1953. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: LAURENCE H. KEDES, M.D.; JAMES V. BONESSI, M.D.; T. S. DANOWSKI, M.D., F.A.C.P.Affiliations: Pittsburgh, PennsylvaniaFrom the Section of Endocrinology and Metabolism of the Department of Medicine, University of Pittsburgh School of Medicine, and the Medical Center and Shadyside Hospital, Pittsburgh, Pa.This work was supported by grant 8M01-FR56-02, U. S. Public Health Service, Bethesda, Md., and grants from the John A. Hartford Foundation, Inc., the Western Pennsylvania Arthritis and Rheumatism Foundation, and the Western Pennsylvania Heart Association.Dr. Bonessi was a Fellow in Endocrinology and Metabolism of the Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pa.Requests for reprints should be addressed to T. S. Danowski, M.D., University of Pittsburgh School of Medicine, Pittsburgh 13, Pa. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byA case of central diabetes insipidus with spontaneous remission after 8 years of the diseaseThe Hypothalamo-neurohypophyseal SystemDas hypothalamo-neurohypophysäre SystemThe Hypothalamo-Neurohypophyseal SystemFactitious hyposthenuria 1 December 1964Volume 61, Issue 6Page: 1128-1133KeywordsChildrenEndocrinologyHeartHomosexualsHospital medicineIngestionMedical servicesRhinitisUrineVasopressin ePublished: 1 December 2008 Issue Published: 1 December 1964 PDF downloadLoading ...