tbuckley/cabot-search huggingface dataset:
Abstract 5275: βII-spectrin(SPTBN1) suppresses tumor progression by inhibiting Wnt signaling via kallistatin in hepatocellular carcinoma
Authors: Xiuling Zhi, Ling Lin, Narayan Shivapurkar Shivapurkar, John L. Marshall, Lynt Johnson, Aiwu R. He
Journal: Cancer Research (2014)

Abstract βII-spectrin(SPTBN1, β2SP), the most common nonerythrocytic member of the β-spectrin gene family, functions as an adapter protein for Smad3/Smad4 complex formation during TGF-β signal transduction, and is required for EMT during embryonic liver development. Moreover, β2SP is emerging as a tumor suppressor. We have reported that Loss of β2SP enhances the stem-like traits and invasiveness of HCC cells. The canonical Wnt pathway, known to be a critical regulator of self-renewal in stem cell, is also constitutively activated and implicated in the induction of EMT in cancer. Kallistatin (a serine protease inhibitor, SERPINA4), which was identified as a unique inhibitor of the Wnt pathway, is expressed primly in the liver. In this study, we investigated the mechanism by which β2SP influences stem cell traits and aggressive behavior of HCC cell lines. We found that cells with decreased β2SP have decreased β-catenin phosphorylation and increased β-catenin nuclear localization, indicative of activation of Wnt signaling. Furthermore, loss of β2SP results in the decease of Kallistatin expression, the Wnt inhibitor. Restore of kallistatin reversed the Wnt activation in HCC cells from decreased β2SP level. Our study provides evidence for the first time that loss of β2SP activates Wnt signal through suppressing kallistatin expression. Note: This abstract was not presented at the meeting. Citation Format: Xiuling Zhi, Ling Lin, Narayan Shivapurkar Shivapurkar, John L. Marshall, Lynt Johnson, Aiwu R. He. βII-spectrin(SPTBN1) suppresses tumor progression by inhibiting Wnt signaling via kallistatin in hepatocellular carcinoma. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 5275. doi:10.1158/1538-7445.AM2014-5275
An Endogenously Produced Fragment of Cardiac Myosin-Binding Protein C Is Pathogenic and Can Lead to Heart Failure
Authors: Md. Abdur Razzaque, Manish Gupta, Hanna Osinska, James Gulick, Burns C. Blaxall, Jeffrey Robbins
Journal: Circulation Research (2013)

A stable 40-kDa fragment is produced from cardiac myosin-binding protein C when the heart is stressed using a stimulus, such as ischemia-reperfusion injury. Elevated levels of the fragment can be detected in the diseased mouse and human heart, but its ability to interfere with normal cardiac function in the intact animal is unexplored.To understand the potential pathogenicity of the 40-kDa fragment in vivo and to investigate the molecular pathways that could be targeted for potential therapeutic intervention.We generated cardiac myocyte-specific transgenic mice using a Tet-Off inducible system to permit controlled expression of the 40-kDa fragment in cardiomyocytes. When expression of the 40-kDa protein is induced by crossing the responder animals with tetracycline transactivator mice under conditions in which substantial quantities approximating those observed in diseased hearts are reached, the double-transgenic mice subsequently experience development of sarcomere dysgenesis and altered cardiac geometry, and the heart fails between 12 and 17 weeks of age. The induced double-transgenic mice had development of cardiac hypertrophy with myofibrillar disarray and fibrosis, in addition to activation of pathogenic MEK-ERK pathways. Inhibition of MEK-ERK signaling was achieved by injection of the mitogen-activated protein kinase (MAPK)/ERK inhibitor U0126. The drug effectively improved cardiac function, normalized heart size, and increased probability of survival.These results suggest that the 40-kDa cardiac myosin-binding protein C fragment, which is produced at elevated levels during human cardiac disease, is a pathogenic fragment that is sufficient to cause hypertrophic cardiomyopathy and heart failure.
Comparison of the Hemodynamic Effects of Exercise and Isoproterenol Infusion in Patients with Pulmonary Valvar Stenosis
Authors: WILLIAM A. NEAL, RUSSELL V. LUCAS, SATYANARAYANA RAO, JAMES H. MOLLER
Journal: Circulation (1974)

In children with congenital cardiac anomalies, isoproterenol has been used to simulate exercise. To determine if these states are comparable, 28 children with pulmonary valvar stenosis were studied by cardiac catheterization at rest, during supine submaximal exercise, and during isoproterenol infusion. Similar heart rates were obtained during exercise (142/min) and isoproterenol infusion (139/min). Cardiac index, right ventricular systolic pressure and oxygen consumption were measured during each physiologic state. The change in pulmonary valve area from rest was calculated. At similar heart rates, cardiac index was significantly greater with exercise than with isoproterenol and right ventricular systolic pressure was similar in the two states. Thus, the calculated pulmonary valve area was significantly smaller with the pharmacologically induced stress. The study indicates that several of the hemodynamic effects of isoproterenol are not comparable to those produced by exercise in patients with pulmonary valvar stenosis.
A NOTE ON THE ETIOLOGY OF BERI-BERI AND THE PRESENCE OF ARSIN IN RICE
Authors: C. N. Saldanha
Journal: BMJ (1908)

CASE II.A Chinese coolie, aged 30, was admitted to hospital on September 20th.His illness had begun two years earlier with skin trouble of the right hand.About six weeks ago the left hand and both feet became similarly affected.He had had no other illness, but had suffered great privation of recent years.There were no signs of syphilis.
MMP-7 promotes prostate cancer-induced osteolysis via the solubilization of RANKL
Authors: Conor C. Lynch, Atsuya Hikosaka, Heath B. Acuff, Michelle D. Martin, Noriyasu Kawai, Rakesh K. Singh, Tracy C. Vargo-Gogola, Jennifer L. Begtrup, Todd E. Peterson, Barbara Fingleton, Tomoyuki Shirai, Lynn M. Matrisian, Mitsuru Futakuchi
Journal: Cancer Cell (2005)
The Lack of the Bronchoprotective and Not the Bronchodilatory Ability of Deep Inspiration Is Associated with Airway Hyperresponsiveness
Authors: NICOLA SCICHILONE, SOLBERT PERMUTT, ALKIS TOGIAS
Journal: American Journal of Respiratory and Critical Care Medicine (2001)

In healthy subjects, deep inspiration (DI) acts both as a bronchodilator and a bronchoprotector. The latter is impaired in asthmatics. We have now evaluated whether the lack of bronchoprotection is related to bronchial hyperresponsiveness (BHR), and whether the bronchodilatory effect is also lost in asthmatics. Ten healthy subjects (PC20 > 75 mg/ml), 12 asthmatics with moderate to severe BHR (PC20 < 1 mg/ml), 14 asthmatics with mild to borderline BHR (1 < PC20 < 25 mg/ml), and 10 rhinitics with mild to borderline BHR (1 < PC20 < 25 mg/ml) underwent single-dose methacholine provocations inducing at least 20% reduction in FEV1 after 20 min of DI inhibition. To measure the bronchodilatory effect, DIs were taken immediately after the postmethacholine spirometry, and lung function was again tested. To measure the bronchoprotective effect, DIs were taken before the administration of spasmogen. All four groups achieved the same reductions in FEV1 and FVC, in the absence of deep breaths (analysis of variance [ANOVA], p = 0.49). Only healthy subjects showed bronchoprotection (percent bronchoprotection, mean ± SEM; healthy: 79 ± 4.0; asthmatics with moderate to severe BHR: 12 ± 14.5; asthmatics with mild to borderline BHR: − 7 ± 19.7; rhinitics with mild to borderline BHR: 2 ± 14.0). In contrast, DIs were able to partially reverse bronchial obstruction in all four groups, albeit percent bronchodilation in healthy subjects was somewhat stronger. The dissociation between bronchoprotection and bronchodilation suggests that the two effects involve different mechanisms.
A congested football calendar and the wellbeing of players: correlation between match exposure of European footballers before the World Cup 2002 and their injuries and performances during that World Cup
Authors: J Ekstrand, M Waldén, M Hägglund
Journal: British Journal of Sports Medicine (2004)

Objectives: To investigate the correlation between exposure of footballers in European clubs to match play in the months before the World Cup 2002 and their injuries and performances during that World Cup. Methods: The team doctors at 11 of the best football clubs in Europe prospectively recorded players’ exposure and injuries during the 2001–2002 season (July 2001–May 2002). Sixty five players participated in the World Cup in Korea/Japan (June 2002). During the World Cup, the clubs reported injuries sustained by these players, and their performance was evaluated by three international experts. Results: The number of team matches during the season varied between 40 and 76 for the different countries involved. The individual player had a mean of 36 matches during the season. Top players played more matches, especially during the final period of the season. Players who participated in the World Cup played more matches during the season than those who did not (46 v 33 matches). World Cup players did not show any increased risk of injury during the season. About 29% incurred injuries during the World Cup, and 32% performed below their normal standard. The players who underperformed had played more matches during the 10 weeks before the World Cup than those who performed better than expected (12.5 v 9, p&lt;0.05). Twenty three (60%) of the 38 players who had played more than one match a week before the World Cup incurred injuries or underperformed during the World Cup. Conclusions: There is considerable variation in the number of matches played per season in European professional football leagues. Top level players are obliged to play many matches especially during the final period of the season.
RESULTS WITH TUBERCULIN (DIXON'S) IN ADVANCED CHRONIC AMBULATORY TUBERCULOSIS
Authors: A. P. FRANCINE
Journal: JAMA (1913)

It is unnecessary in connection with the following report to discuss even by way of introduction the broad question of the use of tuberculin in any of its many relations, as for instance its availability in dispensary practice, which is, we believe, fully established. Our Purpose is to report briefly the results in a series of ambulatory cases, principally because in these cases there was a peculiarly favorable opportunity to eliminate other causes of improvement, and so to estimate effect of the tuberculin<i>per se</i>. All those in the series were patients at the State Tuberculosis Dispensary in Philadelphia (No. 21) and had been under observation continuously for a period of several years before being brought together in a special tuberculin class.<sup>1</sup>They had all had a prolonged course of treatment at the State Sanatorium at Mont Alto (there were two previously treated at White Haven), and had returned
Transient Renal-Artery Stenosis
Authors: Gurdarshan S. Thind, Stanley Baum, Koson Kuroda
Journal: New England Journal of Medicine (1968)

Selective left renal and midstream abdominal aortography demonstrated functional main-renal-artery stenosis in a 39-year-old man. This was associated with increased renin activity in the renal venous effluent obtained one week after the arteriogram. The anatomic and functional abnormalities of renal-artery stenosis had disappeared completely by the time of restudy 14 months later.
Reimbursement for In Vitro Allergy Tests-Reply
Authors: Russell I. Williams
Journal: JAMA (1991)

<h3>In Reply.—</h3> I agree with Bousquet and Michel that there are no tests that are a substitute for the physician's assessment of an individual patient's problems. However, arguing that a better test for allergy disease is likely to contribute to an increase in allergy costs is difficult for me to comprehend. The experience among members of our society (American In Vitro Allergy and Immunology Society) indicates that there are large numbers of patients who had met the criteria for allergy immunotherapy by previous standards but who are RAST negative. Despite low IGE scores, both specific and total, most of these patients had been undergoing injection therapy for years and had been referred for a second opinion, only to discover that they were not in a group that could benefit from immunotherapy. Our argument would be that in vitro testing has a better chance of distinguishing the truly allergic from the
Accumulation of methotrexate polyglutamates in lymphoblasts is a determinant of antileukemic effects in vivo. A rationale for high-dose methotrexate.
Authors: E Masson, M V Relling, T W Synold, Q Liu, J D Schuetz, J T Sandlund, C H Pui, W E Evans
Journal: Journal of Clinical Investigation (1996)

Methotrexate (MTX) is one of the most widely used drugs for the treatment of childhood acute lymphoblastic leukemia (ALL) and is commonly given in high doses. However, the rationale for high-dose MTX (HDMTX) has been challenged recently. To determine whether higher MTX polyglutamate (MTXPG) concentrations in ALL blasts translate into greater antileukemic effects, 150 children with newly diagnosed ALL were randomized to initial treatment with either HDMTX (1,000 mg/m2 intravenously over 24 h) or lower-dose MTX (30 mg/m2 by mouth every 6 h x 6). ALL blasts accumulated higher concentrations of MTXPG and long-chain MTXPG (MTXPGLC) after HDMTX (P < 0.00001). Of 101 patients evaluable for peripheral blast cytoreduction, MTXPG concentrations were higher in patients whose blast count decreased within 24 h (P = 0.005) and in those who had no detectable circulating blasts within 4 days (P = 0.004). The extent of inhibition of de novo purine synthesis in ALL blasts was significantly related to the blast concentration of MTXPGLC (IC95% = 483 pmol/10(9) blasts). The percentage of patients with 44-h MTXPGLC exceeding the IC95% was greater after HDMTX (81%) than LDMTX (46%, P < 0.0001). These data indicate that higher blast concentrations of MTXPG are associated with greater antileukemic effects, establishing a strong rationale for HD-MTX in the treatment of childhood ALL.
Potentially Inappropriate Medication Use in the Community-Dwelling Elderly
Authors: Chunliu Zhan, Judith Sangl, Arlene S. Bierman, Marlene R. Miller, Bruce Friedman, Steve W. Wickizer, Gregg S. Meyer
Journal: JAMA (2001)

ContextInappropriate medication use is a major patient safety concern, especially for the elderly population. Using explicit criteria, prior studies have found that 23.5% and 17.5% of the US community-dwelling elderly population used at least 1 of 20 potentially inappropriate medications in 1987 and 1992, respectively.ObjectivesTo determine the prevalence of potentially inappropriate medication use in community-dwelling elderly persons in 1996, to assess trends over 10 years, categorize inappropriate medication use according to explicit criteria, and to examine risk factors for inappropriate medication use.Design, Setting, and ParticipantsRespondents aged 65 years or older (n = 2455) to the 1996 Medical Expenditure Panel Survey, a nationally representative survey of the US noninstitutionalized population were included. A 7-member expert panel was convened to categorize inappropriate medications.Main Outcome MeasurePrevalence of use of 33 potentially inappropriate medications.ResultsIn 1996, 21.3% (95% confidence interval [CI], 19.5%-23.1%) of community-dwelling elderly patients in the United States received at least 1 of 33 potentially inappropriate medications. Using the expert panel's classifications, about 2.6% of elderly patients (95% CI, 2.0%-3.2%) used at least 1 of the 11 medications that should always be avoided by elderly patients; 9.1% (95% CI, 7.9%-10.3%) used at least 1 of the 8 that would rarely be appropriate; and 13.3% (95% CI, 11.7%-14.9%) used at least 1 of the 14 medications that have some indications but are often misused. Use of some inappropriate medications declined between 1987 and 1996. Persons with poor health and more prescriptions had a significantly higher risk of inappropriate medication use.ConclusionsOverall inappropriate medication use in elderly patients remains a serious problem. Despite challenges in using explicit criteria for assessing inappropriate medications for elderly patients, such criteria can be applied to population-based surveys to identify opportunities to improve quality of care and patient safety. Enhancements of existing data sources to include dosage, duration, and indication may augment national improvement and monitoring efforts.
Borage oil, an effective new treatment for infantile seborrhoeic dermatitis
Authors: A. Tollesson, A. Frithz
Journal: British Journal of Dermatology (1993)

Journal Article Borage oil, an effective new treatment for infantile seborrhoeic dermatitis Get access A. Tollesson, A. Tollesson Karolinska Institutet, Department of Dermatology, Södersjukhuset, S–118 83 Stockholm, Sweden Search for other works by this author on: Oxford Academic Google Scholar A. Frithz A. Frithz Karolinska Institutet, Department of Dermatology, Södersjukhuset, S–118 83 Stockholm, Sweden Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 129, Issue 1, 1 July 1993, Page 95, https://doi.org/10.1111/j.1365-2133.1993.tb03322.x Published: 01 July 1993
Myocardial stunning: a role for calcium antagonists during reperfusion?
Authors: L. Opie
Journal: Cardiovascular Research (1992)

Journal Article Myocardial stunning: a role for calcium antagonists during reperfusion? Get access Lionel Opie Lionel Opie Heart Research Unit, University of Cape Town, Medical School, Observatory 7925, Cape Town, South Africa: Professor L H Opie Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 26, Issue 1, January 1992, Pages 20–24, https://doi.org/10.1093/cvr/26.1.20 Published: 01 January 1992
Diagnosis of Hypotonic States
Authors: PETER U. FEIG
Journal: Annals of Internal Medicine (1978)

Letters and Corrections1 May 1978Diagnosis of Hypotonic StatesPETER U. FEIG, M.D., RICHARD H. STERNS, M.D.PETER U. FEIG, M.D.Search for more papers by this author, RICHARD H. STERNS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-88-5-717_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In a recent report of another case of carbamazepine-induced hypotonicity (1), the authors claim that "inappropriate antidiuresis can be diagnosed when hyponatremia with serum hypo-osmolal to urine occurs . . ." This may well be the most widespread misconception in the diagnostic evaluation of hypotonic states. The appropriate response to hypotonicity is diuresis via maximal urinary dilution, that is, urinary osmolality (Uosm) in two-digit range. Any Uosmgreater than 100 mosmol/kg H2Orepresents some degree of antidiuresis (2). Hyponatremia develops when water intake exceeds total water losses and it is maintained by zero water balance (in spite...References1. FLEGELCOLE KC: Inappropriate antidiuresis during carbamazepine treatment. Ann Intern Med 87:722-723, 1977 LinkGoogle Scholar2. BARRTERSCHWARTZ FW: The syndrome of inappropriate secretion of antidiuretic hormone. Am J Med 42:790-806, 1967 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Pennsylvania School of Medicine V. A. Hospital Philadelphia, PA 19104 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1978Volume 88, Issue 5Page: 717-717KeywordsHyponatremiaHypotonicityUrine Issue Published: 1 May 1978 PDF DownloadLoading ...
Endoscopic and Histopathologic Features of Degos' Disease
Authors: M. K. Casparie, J. W. R. Meyer, B. E. W. van Huystee, J. Kneppelhout, C. J. J. Mulder
Journal: Endoscopy (1991)

The case is reported of a 69-year-old female with atrophic papules on the skin who developed multiple spontaneous intestinal perforations of which she eventually died. The skin lesions in combination with lesions in the gastrointestinal tract are typical for Degos' disease or malignant atrophic papulosis. The characteristic histopathological and endoscopic features of this rare disease are reported. This case demonstrates the importance of routinely performing endoscopy in Degos' disease to detect silent perforation, even in patients without gastrointestinal complaints.
Vasopressin, "Torsades de Pointes," and QT Syndrome
Authors: GEORGE J. KLEIN
Journal: Annals of Internal Medicine (1980)

Letters and Corrections1 September 1980Vasopressin, "Torsades de Pointes," and QT SyndromeGEORGE J. KLEIN, M.D.GEORGE J. KLEIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-93-3-511_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I read with interest the well-documented case report by Kelly and colleagues (1) on provocation of ventricular dysrhythmia by vasopressin in a patient without apparent heart disease. These authors apparently concluded that coronary spasm was an unlikely mechanism for the occurrence of ventricular fibrillation in their patient but did not offer an alternate explanation.Their Figure 1 suggests to me that this patient developed ventricular fibrillation after a run of "torsades de pointes" (2). This arrhythmia is characterized by an alternating electrical polarity during ventricular tachycardia so that the peaks of the QRS complexes appear to be...References1. KELLYSTANGMEKHJIAN KJH. Vasopressin provocation of ventricular dysrhythmia. Ann Intern Med. 1980;93:205-6. LinkGoogle Scholar2. DESSERTENNE F. La tachycardie ventricularie a deux foyers opposes variable. Arch Mal Coeur. 1966;59:263-72. MedlineGoogle Scholar3. KRIKLERCURRY DP. Torsade de pointes, an atypical ventricular tachycardia. Br Heart J. 1976;38:117-20. CrossrefMedlineGoogle Scholar4. SCHWARTZPERITIMALLIANI PMA. The Long Q-T syndrome. Am Heart J. 1975;89:378-90. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: GEORGE J. KLEIN, M.D.Affiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySummary of Torsades de Pointes (TdP) Reports Associated with Intravenous Drug Formulations Containing the Preservative ChlorobutanolEfficacy and safety of terlipressin in cirrhotic patients with variceal bleeding or hepatorenal syndrome 1 September 1980Volume 93, Issue 3Page: 511-512KeywordsArrhythmiaCardiovascular therapyVasopressinVentricular fibrillationVentricular tachycardia ePublished: 1 December 2008 Issue Published: 1 September 1980 PDF downloadLoading ...
Should She or Shouldn’t She?
Authors: Lisa M. Rogers, Lois Jovanovic, Dorothy J. Becker
Journal: Diabetes Care (2005)

Now more than ever, women with type 1 diabetes are able to bear healthy children. Nevertheless, the concern that early infant nutrition plays a role in subsequent diabetes development in the offspring remains an important issue. Though we still do not know the exact causes of type 1 diabetes, recent research indicates that both genetic and environmental issues are contributing factors.

A possible link between early infant nutrition and the risk of developing type …