tbuckley/cabot-search huggingface dataset:
SleepMultiMedia: The Comprehensive Computerized Textbook of Sleep Medicine With Text, Sound, Graphics, Animation, and Video
Authors: Robert G. Gillio
Journal: JAMA (1995)

I reviewed SleepMultiMedia on an IBM PC compatible 80486/DX66 computer with Microsoft Windows 3.1, a double-speed CD-ROM drive, and Soundblaster audiocard. A main-screen table of contents has buttons that give direct access to any of the product's seven parts. These include "How To Use SleepMultiMedia," "Physiology of Sleep," "Insomnia," "Obstructive Sleep Apnea Syndrome," "Narcolepsy," "Parasomnias," and "Practice Parameters." Each part has its own specific table of contents, which one can work through using standard point-and-click mouse actions. The means of navigation through the program are intuitive and easy to follow. A tool bar across the top of the screen allows access to any point in the program from any other point directly or through table of contents screens and decision screens. Interspersed throughout the program are audio and/or audio-and-video files. When one accesses a video file, a small 1½ × 1½-in video comes on the screen. The audio is of
London GPs face charade to admit patients
Authors: S Kingman
Journal: BMJ (1994)

Many general practitioners in London have to go through a “time-wasting charade” before getting their patients admitted to hospital, an investigation into London's emergency services by the King's Fund Institute has found. More than one in three general practitioners in London had difficulty getting patients admitted to hospital in an emergency, the report says. Discussions between general practitioners trying to admit patients and hospital doctors could degenerate into confrontation, and when a general practitioner cannot obtain an admission by negotiation “referral to the Emergency Bed Service …
778 SUSTAINED VIROLOGICAL RESPONSE IS ASSOCIATED WITH REVERSIBILITY OF CIRRHOSIS IN CHRONIC HEPATITIS C PATIENTS
Authors: A.C. Cardoso, R. Moucari, N. Giuily, C. Figueiredo-Mendes, N. Boyer, M.P. Ripault, C. Castelnau, T. Asselah, M. Martinot-Peignoux, S. Maylin, P. Bedossa, P. Marcellin
Journal: Journal of Hepatology (2008)
FULLY AUTOMATED QUANTIFICATION OF LEFT VENTRICULAR AND LEFT ATRIAL VOLUMES FROM TRANSTHORACIC 3D ECHOCARDIOGRAPHY: A VALIDATION STUDY
Authors: Wendy Tsang, Ivan S. Salgo, Lyubomir Zarochev, Scott Settlemier, Nicole Bhave, Juergen Weese, Irina Waechter-Stehle, Michael Cardinale, Aldo Prado, Lynn Weinert, Amit R. Patel, Roberto M. Lang
Journal: Journal of the American College of Cardiology (2013)
High-Dose Statins and the IDEAL Study—Reply
Authors: Terje R. Pedersen, Ole Faergeman, John J. P. Kastelein, Anders G. Olsson, Matti J. Tikkanen, Ingar Holme, Mogens Lytken Larsen, Fredrik S. Bendiksen
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 3873: Squalene enhanced chemotherapy and radiation therapy sensitivity in mice through the inhibition of DNA damage checkpoint activity
Authors: Hiroshi Nishida, Naoto Tatewaki, Yuki Nakajima, Kayoko Nakayama-Kawakami, Kiyomi Kasai-Eguchi, Kazunori Anzai, Tetsuya Konishi, Nobuo Ikekawa
Journal: Cancer Research (2010)

Abstract ATM (Ataxia Telangiectasia Mutated) protein kinase plays a crucial role in cellular DNA damage responses. The inhibition of ATM leads to an abolishment of one such signal pathways termed as “checkpoints”. It is expected that the discovery of checkpoint inhibitor will be an effective assistance of anti-cancer therapy. Recent study reported that Wip1, a magnesium dependent protein phosphatase, de-phosphorylates molecules involved DNA damage checkpoint response such ATM (Ser1981). On the other hand, Squalene (SQ) has been thought to assist anti-cancer therapies such as chemo and/or radiation therapy though there is few available data which refer to its detailed mechanisms. We previously showed that SQ enhances the γ-irradiation (IR) sensitivity through the induction of Wip1 in A549 adenocarcinoma cells. It was indicated that IR induced DNA damage checkpoint was abrogated by SQ pre-treatment, and led to the shrinkage of tumor in vivo. Here, we report SQ sensitizes chemotherapy and an advanced radiation therapy, heavy ion (HI) exposure, in mice using allo/xeno-graft model. Mouse Colon-26 and human MKN45 cells (5 × 106 cells/ mouse) were transplanted into Balb/c and SCID mice, respectively. The tumor volumes were estimated by measuring the growing diameters of tumor tissue every day. SQ (200μl, oral administration) was challenged after day-8 and later days. Chemotherapy using DOX (2 mg/kg, i.p.) was conducted in same days with SQ. One-time exposure of HI (Carbon, 290MeV) was performed on the day-8 in NIRS (National Institute of Radiological Sciences, Japan). Marked change of body weight was not observed between the treatments. DOX and HI prevented the tumor growth. SQ itself inhibited tumor growth slightly. The administration of SQ significantly improved the efficacy of DOX and HI on tumor growth. Wip1 protein expression in tumor tissue was detected by western blot analysis, and was elevated by the oral administration of SQ. These results were confirmed in xenograft model using MKN45 cells and SCID mice. Taken together these findings, SQ sensitized chemo/radio therapy through the inhibition of DNA damage checkpoint activity by Wip1. Further in-depth study is required to determine the clinical feasibility of SQ as a sensitizing agent for anti-cancer therapy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3873.
Five Tamil Nadu doctors banned from practice for violating prenatal sex selection law
Authors: M. Kay
Journal: BMJ (2013)

The Tamil Nadu Medical Council has banned five doctors from practising for violating provisions of the 1994 Pre-conception and Pre-natal Diagnostic Techniques Act.

The act, amended before coming into effect in 2003, regulates prenatal diagnostic techniques in India and prohibits their misuse for sex selection. There have been waves of suspensions of doctors for violating the act.

However, implementation of the act rests with states, and enforcement is devolved to appropriate district authorities.

A report published in the Hindu newspaper said that the Tamil Nadu government had recently sent a recommendation …
Drug combinations and all cause mortality in heart disease: Authors' reply
Authors: Julia Hippisley-Cox, Carol Coupland
Journal: BMJ (2005)

Drug combinations and all cause mortality in heart disease No new insights were gainedEditor-Hippisley-Cox and Coupland conclude that the addition of angiotensin converting enzyme (ACE) inhibitors to combinations of drugs conferred no additional benefit in their study of patients in primary care with ischaemic heart disease. 1 However, such a conclusion should be reached with caution.The drugs were given to the patients with the highest risk of death.A higher percentage of patients who died were treated with ACE inhibitors, and the greatest improvement in risk of death after adjustment for risk factors was seen in the patients treated with these drugs.ACE inhibitors might thus have been given to the patients with the most severe disease in each comorbidity group-for example, to diabetic patients with kidney disease and to patients with the most severe heart failure.Therefore the study can give no indication of the crucial question whether the outcome would have been equally good for the group of 463 patients who probably had the most severe disease and received statins, aspirin, blockers, and ACE inhibitors if they had not been given ACE inhibitors.Replacement of yes or no for comorbidity factors with more discriminating variables, such as presence of microalbuminuria and a severity measure for heart disease, would probably have improved the study.However, this cannot replace the quality of a randomised, placebo controlled study comparing the effect of adding ACE inhibitors to the other study drugs.Therefore the study by Hippisley-Cox and Coupland adds no new knowledge to how patients with ischaemic heart disease in primary care should be treated.
The Electrocardiogram of the South African Bantu
Authors: J. D. WOODS, W. LAURIE
Journal: Circulation (1959)

Considerable attention has been directed to the "suggested" low incidence of atheroselerosis in the Bantu and its relation to diet and blood lipids. Electrocardiographic abnormalities found in the Bantu have been regarded as unreliable evidence either of the presence or the nature of heart disease in these subjects and hence not inconsistent with the alleged freedom of heart disease in these people. In the present study the authors challenge the validity of such an interpretation of electrocardiographic changes.
Effect of early propranolol treatment in an animal model of congestive cardiomyopathy: I Mortality and Ca2+ transport in sarcoplasmic reticulum
Authors: N. A STALEY, G. R NOREN, S. EINZIG, T. G RUBLEIN
Journal: Cardiovascular Research (1984)

Journal Article Effect of early propranolol treatment in an animal model of congestive cardiomyopathy: I Mortality and Ca2+ transport in sarcoplasmic reticulum Get access NANCY A STALEY, NANCY A STALEY * From the Department of Pathology, Veterans Administration Medical Center; Department of Pediatrics, Hennepin County Medical Center; and University of Minnesota, Minneapolis, Minnesota *Address for reprints: Nancy A Staley MD, Pathology, VA Medical Center, 4801 East 54th St, Minneapolis, MN 55417. Search for other works by this author on: Oxford Academic PubMed Google Scholar GEORGE R NOREN, GEORGE R NOREN From the Department of Pathology, Veterans Administration Medical Center; Department of Pediatrics, Hennepin County Medical Center; and University of Minnesota, Minneapolis, Minnesota Search for other works by this author on: Oxford Academic PubMed Google Scholar STANLEY EINZIG, STANLEY EINZIG From the Department of Pathology, Veterans Administration Medical Center; Department of Pediatrics, Hennepin County Medical Center; and University of Minnesota, Minneapolis, Minnesota Search for other works by this author on: Oxford Academic PubMed Google Scholar THOMAS G RUBLEIN THOMAS G RUBLEIN From the Department of Pathology, Veterans Administration Medical Center; Department of Pediatrics, Hennepin County Medical Center; and University of Minnesota, Minneapolis, Minnesota Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 18, Issue 6, June 1984, Pages 371–376, https://doi.org/10.1093/cvr/18.6.371 Published: 01 June 1984
Tumor Necrosis Factor Inhibitors for Rheumatoid Arthritis
Authors: D.L. Scott, G.H. Kingsley
Journal: New England Journal of Medicine (2006)

Rheumatoid arthritis that was resistant to methotrexate and sulfasalazine developed in a 25-year-old woman who was evaluated for possible treatment with a tumor necrosis factor inhibitor. These agents are effective in some patients who have not had a response to other therapies. They increase the risk of infection, and their long-term efficacy and safety are not established.
Gallium-67 Uptake After Breast and Hip Augmentation with Silicone
Authors: CHRISTOPHER J. PALESTRO, PETER CHAU, STANLEY J. GOLDSMITH
Journal: Clinical Nuclear Medicine (1992)

A 35-year-old transsexual underwent Ga-67 scintigraphy because of cough and dyspnea on exertion. Although no pulmonary abnormalities were identified, increased radiotracer localization in the breasts and both hips was observed. On questioning, the patient revealed that breast and hip augmentation with silicone was part of the male-to-female transformation she had undergone about 10 years previously.
Abstract 1231: Differential roles of trans-phophorylated EGFR, HER2, HER3 and RET as heterodimerization partenrs of MET in lung cancer with MET amplification
Authors: Junko Tanizaki, Isamu Okamoto, Kazuko Sakai, Kazuhiko Nakagawa
Journal: Cancer Research (2012)

Abstract Background: MET is a receptor tyrosine kinase (RTK) whose gene is amplified in various tumor types. We investigated the roles and mechanisms of RTK heterodimerization in lung cancer with MET amplification. Methods: With the use of an RTK array, we identified several phosphorylated RTKs in lung cancer cells with MET amplification. We examined the roles and mechanisms of action of these RTKs with immunoprecipitation, annexin V binding, and cell migration assays. Results: We identified EGFR, HER2, HER3, and RET in addition to MET as highly phosphorylated RTKs in lung cancer cells with MET amplification. Immunoprecipitation revealed that EGFR, HER2, HER3, and RET each formed a heterodimer exclusively with MET and that these associations were markedly reduced in extent by treatment with a MET kinase inhibitor, but not by treatment with their spcific inhibitors. RNA interference-mediated depletion of EGFR, HER2, or HER3 induced apoptosis in association with inhibition of AKT and ERK signaling pathways, whereas depletion of HER2 or RET inhibited both cell migration and STAT3 signaling. Conclusion: Our data suggest that heterodimers of MET with EGFR, HER2, HER3, or RET play differential roles in tumor development, and they provide new insight into the function of trans-phosphorylated RTKs as heterodimerization partners of MET in lung cancer with MET amplification. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1231. doi:1538-7445.AM2012-1231
Depression Predicts Increased Incidence of Adverse Health Outcomes in Older Mexican Americans With Type 2 Diabetes
Authors: Sandra A. Black, Kyriakos S. Markides, Laura A. Ray
Journal: Diabetes Care (2003)

OBJECTIVE—To examine the separate and combined effects of depression and diabetes on the incidence of adverse health outcomes among older Mexican Americans. RESEARCH DESIGN AND METHODS—Longitudinal data from the Hispanic Established Population for the Epidemiologic Study of the Elderly (EPESE) survey were used to examine the main effects and interaction effects of diabetes and depressive symptoms (measured with the Center for Epidemiologic Study of Depression) or clinical diagnostic criteria (measured with the Composite International Diagnostic Interview Depression Module) on the development of macrovascular complications (including cardiovascular disease, stroke, and kidney disease), microvascular complications (including nephropathy, neuropathy, retinopathy, and amputations), functional disability, and mortality over 7 years in a sample of 2,830 Mexican Americans aged ≥65 years. RESULTS—The interaction of diabetes and depression was found to be synergistic, predicting greater mortality, greater incidence of both macro- and microvascular complications, and greater incidence of disability in activities of daily living, even when controlling for sociodemographic characteristics such as sex, age, education, acculturation, and marital status. Importantly, this interaction was found to predict not only greater incidence but also earlier incidence of adverse events in older adults. CONCLUSIONS—Whether a marker for underlying disease severity, an indicator of diminished self-care motivation, or the result of physiologic changes, the interaction of depression and diabetes has a synergistic effect on the health of older Mexican Americans, increasing the risk for poor outcomes. This is of particular clinical importance because although depression is often underrecognized in older adults, effective treatment is available and can result in improved medical outcomes.
A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand-induced apoptosis.
Authors: G Süss, K Shortman
Journal: The Journal of Experimental Medicine (1996)

Dendritic cells (DC), the most efficient antigen-presenting cells, are well equipped for activation of naive CD4+ T cells by their expression of high levels of major histocompatibility complex and costimulator molecules. We now demonstrate that some DC are equally well equipped for killing these same T cells. Murine splenic DC consist of both conventional CD8alpha- DC and a major population of CD8alpha+ DC. Whereas CD8- DC induce a vigorous proliferative response in CD4 T cells, CD8+ DC induce a lesser response that is associated with marked T cell apoptosis. By using various mixtures of T cells and DC from Fas-mutant lpr/lpr mice and Fas-ligand (FasL) mutant gld/gld mice, we show this death is due to interaction of Fas on activated T cells with FasL on CD8+ DC. Furthermore, we show by direct surface staining that CD8+ DC, but not CD8- DC, express FasL at high levels. These findings indicate that FasL+ CD8+ DC are a specialized subgroup of DC with a role in the regulation of the response of primary peripheral T cells.
Meltdown: the media and mad cows
Authors: T. Delamothe
Journal: BMJ (1996)

Newspapers, whose columnists had been burbling on about the delights of eating British beef only weeks before, cleared their front pages for what they said might be the biggest public health calamity this century. They took their lead from the previous night's television programmes. In successive appearances, an increasingly palefaced Stephen Dorrell reprised his Commons statement of that afternoon (p 795). Professor John Pattison, head of the government's Spongiform Encephalopathy Advisory Committee, refused to offer much reassurance other than attributing the 10 new cases of Creutzfeldt-Jakob disease (CJD) to exposure to affected beef before 1989. (No one probed the plausibility of this attribution hard enough.)

The opinions of Professor Richard Lacey, who had been consigned to the scientific wilderness for his views on spongiform encephalopathies, were suddenly of interest. But few newspapers could bring themselves to quote his upper estimate of 500000 new cases of CJD a year.

Thursday was human victims day, with the blurred family snaps of those who had succumbed to CJD staring out from the front pages. One of them was repeatedly referred to as a vegetarian—which he had been at the time of his death—despite his distraught mother telling television audiences the night before that his favourite snack was hamburgers. This “it's all so confusing; even the experts can't agree” line can be reliably depended on to cloud public understanding of any complex scientific issue.

The Daily Telegraph argued that any alarm should be kept in perspective. “Life is a hazardous business. But among all the hazards we face, eating beef must rank as minor, even after yesterday's news.” …
Airway Smooth Muscle in Bronchial Tone, Inflammation, and Remodeling
Authors: Reynold A. Panettieri, Michael I. Kotlikoff, William T. Gerthoffer, Marc B. Hershenson, Prescott G. Woodruff, Ian P. Hall, Susan Banks-Schlegel
Journal: American Journal of Respiratory and Critical Care Medicine (2007)

Airway smooth muscle (ASM) plays a pivotal role in modulating bronchomotor tone but also orchestrates and perpetuates airway inflammation and remodeling. Despite substantial research, there remain important unanswered questions. In 2006, the National Heart, Lung, and Blood Institute sponsored a workshop to define new directions in ASM biology. Important questions concerning the key functions of ASM include the following: Does developmental dysregulation of ASM function promote airway disease, what key signaling pathways in ASM evoke airway hyperresponsiveness in vivo, do alterations in ASM mass affect excitation-contraction coupling, and can ASM modulate airway inflammation and remodeling in a physiologically relevant manner? This workshop identified critical issues in ASM biology to delineate areas for scientific investigation in the identification of new therapeutic and diagnostic approaches in asthma, chronic obstructive pulmonary disease, and cystic fibrosis.
Would doctors routinely asking older patients about their memory improve dementia outcomes? Yes
Authors: J. Rasmussen
Journal: BMJ (2013)

The UK government is planning to introduce incentives for general practitioners to check for dementia in all patients aged 75 and older. <b>Jill Rasmussen</b> says that it will allow earlier support for patients with dementia, but <b>Margaret McCartney</b> (doi:10.1136/bmj.f1745) says that industry has more to gain than patients
Skin problems in blacks receive scrutiny
Authors: Beverly J. Montgomery
Journal: JAMA (1979)

In the last five years, there has been a growing movement to educate physicians about dermatologic conditions of blacks and other darkly pigmented people. And for the third successive year, the topic of black dermatology has attracted attention at the annual meeting of the American Academy of Dermatology (AAD). Physicians who discuss these problems share a basic concern: to make practitioners aware that black patients need different or more moderate treatment for many skin conditions. Traditionally even dermatologists confuse normal with abnormal in black skin, and most textbooks concentrate on the skin of whites, except to note diseases unique to particular genetic groups. By and large, conditions and complications that are manifested differently in the heavily pigmented populations are overlooked. Furthermore, white physicians overwhelmingly dominate the specialty of dermatology. Counting residents, there are fewer than 90 practicing black dermatologists in the nation. This lack of input by black professionals has