tbuckley/cabot-search huggingface dataset:
A NEW BINAURAL STETHOSCOPE WITH ARMAMENTARIUM FOR COMPLETE PHYSICAL EXAMINATION.
Authors: S. A. KNOPF
Journal: JAMA (1898)

On March 16 last, I demonstrated to the Section of General Medicine of the New York Academy, an improved stethoscope with an attachable plessimeter.<sup>1</sup>Its daily use since then has shown me some of its imperfections and I have been working for months on the instrument with the object to improve it and above all simplify its use. I am able this evening to present to you the result of my labor, thanks to the courtesy which you extend to me as your guest, and since the instrument differs in all its details from any one thus far devised I may perhaps call it "a new binaural stethoscope." You will see at a glance that it has neither eartips nor front springs, nor the heavy metal conducting tubes of the ordinary binaural stethoscope. Among students and in hospital services it is not infrequent that one stethoscope passes from ear to
AN EXPEDIENT TO CONTROL EPISTAXIS
Authors: Joseph G. Levine
Journal: JAMA (1924)

Nasal hemorrhage, in most instances, is usually controlled without great effort if the bleeding is not marked. On the contrary, violent bleeding or a steady, consistent ooze sometimes taxes the resources of the physician and persists in spite of the use of all available remedies. A nasal hemorrhage is the most common form of bleeding in the human body. In the majority of cases, bleeding is confined to a comparatively limited area on the anterior portion of the cartilaginous septum. This region is known as Kiesselbach's area. It bleeds very easily both from local and from general causes, because of the distribution of its vessels. A thin plate of cartilage is covered on each side by mucous membrane. It is important that it receives an abundant blood supply. As the arteries are in the mucous membrane, they are superficial and liable to injury, and cannot retract into deeper tissue after
Molecular screening in Sicilian families with hereditary non-poliposis colorectal cancer (H.N.P.C.C.) syndrome: Identification of a novel mutation in MSH2 gene
Authors: Andrea Cavallaro, Angela Russo, Vito Emanuele Catania, Bartolomea Ficili, Fabrizio Romano, Andrea Valentino Failla, Alessandro Cappellani, Ferdinando Cammisuli, Maria Viola, Roberto Madeddu, Vincenzo Trichilo, Massimo Libra, Salvatore Travali
Journal: International Journal of Surgery (2014)
Newly diagnosed acute lymphoblastic leukemia in China (II): prognosis related to genetic abnormalities in a series of 1091 cases
Authors: J-Q Mi, X Wang, Y Yao, H-J Lu, X-X Jiang, J-F Zhou, J-H Wang, B Jiao, S-H Shen, J-Y Tang, L-J Gu, H Jiang, L-Y Ma, S-G Hao, F-Y Chen, S-M Xiong, Z-X Shen, Z Chen, B Chen, S-J Chen
Journal: Leukemia (2012)
Why Patients Use Alternative Medicine
Authors: John A. Astin
Journal: JAMA (1998)

Context.-Research both in the United States and abroad suggests that significant numbers of people are involved with various forms of alternative medicine.However, the reasons for such use are, at present, poorly understood.Objective.-Toinvestigate possible predictors of alternative health care use.Methods.-Three primary hypotheses were tested.People seek out these alternatives because (1) they are dissatisfied in some way with conventional treatment; (2) they see alternative treatments as offering more personal autonomy and control over health care decisions; and (3) the alternatives are seen as more compatible with the patients' values, worldview, or beliefs regarding the nature and meaning of health and illness.Additional predictor variables explored included demographics and health status.Design.-A written survey examining use of alternative health care, health status, values, and attitudes toward conventional medicine.Multiple logistic regression analyses were used in an effort to identify predictors of alternative health care use.Setting and Participants.-Atotal of 1035 individuals randomly selected from a panel who had agreed to participate in mail surveys and who live throughout the United States.Main Outcome Measure.-Use of alternative medicine within the previous year.Results.-The response rate was 69%.The following variables emerged as predictors of alternative health care use: more education (odds ratio [OR], 1.2; 95% confidence interval [CI], 1.1-1.3);poorer health status (OR, 1.3; 95% CI, 1.1-1.5); a holistic orientation to health (OR, 1.4; 95% CI, 1.1-1.9);having had a transformational experience that changed the person's worldview (OR, 1.8; 95% CI, 1.3-2.5);any of the following health problems: anxiety (OR, 3.1; 95% CI, 1.6-6.0);back problems (OR, 2.3; 95% CI, 1.7-3.2);chronic pain (OR, 2.0; 95% CI, 1.1-3.5);urinary tract problems (OR, 2.2; 95% CI, 1.3-3.5);and classification in a cultural group identifiable by their commitment to environmentalism, commitment to feminism, and interest in spirituality and personal growth psychology (OR, 2.0; 95% CI, 1.4-2.7).Dissatisfaction with conventional medicine did not predict use of alternative medicine.Only 4.4% of those surveyed reported relying primarily on alternative therapies.Conclusion.-Along with being more educated and reporting poorer health status, the majority of alternative medicine users appear to be doing so not so much as a result of being dissatisfied with conventional medicine but largely because they find these health care alternatives to be more congruent with their own values, beliefs, and philosophical orientations toward health and life.
Positron-Emission Tomography and Assessment of Cancer Therapy
Authors: Malik E. Juweid, Bruce D. Cheson
Journal: New England Journal of Medicine (2006)

Positron-emission tomography (PET) is a noninvasive imaging technique that exploits the unique decay physics of positron-emitting isotopes. The isotopes of oxygen, carbon, nitrogen, and fluorine have been used in the development of diagnostically useful biologic compounds that are available for PET imaging in order to provide a functional or metabolic assessment of normal tissues or disease conditions.The past few years have seen a tremendous expansion of clinical applications of PET, particularly in oncology, mostly with the use of 18F-fluorodeoxyglucose (18F-FDG) as the PET tracer. PET with 18F-FDG is now being used in the evaluation of several neoplasms, both . . .
Potential risks of bone marrow cell transplantation into infarcted hearts
Authors: Martin Breitbach, Toktam Bostani, Wilhelm Roell, Ying Xia, Oliver Dewald, Jens M. Nygren, Jochen W. U. Fries, Klaus Tiemann, Heribert Bohlen, Juergen Hescheler, Armin Welz, Wilhelm Bloch, Sten Eirik W. Jacobsen, Bernd K. Fleischmann
Journal: Blood (2007)
Faecal bile acid concentration of patients with carcinoma or increased risk of carcinoma in the large bowel.
Authors: D G Mudd, S T McKelvey, W Norwood, D T Elmore, A D Roy
Journal: Gut (1980)

Faecal 3-hydroxy bile acids were assayed enzymatically in patients with carcinoma, or at increased risk of developing carcinoma of the large bowel. No rise in bile acid concentration was demonstrated in patients with ulcerative colitis, previously resected adenoma, or resected carcinoma. Patients with carcinoma, before treatment, had faecal bile acid concentrations similar to control values, and surgery did not affect the mean level. These findings cast doubt on the importance of the 3-hydroxy bile acid concentration in the faeces in the pathogenesis of large bowel cancer.
Norwegian Scabies in a Renal Transplant Patient
Authors: Eva Youshock
Journal: JAMA (1981)

A 23-year-old renal transplant patient was seen for a ten-month history of mildly pruritic hyperkeratotic skin lesions. Norwegian scabies was suspected and proved to be present by a potassium hydroxide preparation of skin scrapings. With the current widespread use of immunosuppressive agents, physicians should be aware of the increased incidence of this entity. (<i>JAMA</i>1981;246:2608-2609)
Understanding clinical trials
Authors: D L Sackett, R J Cook
Journal: BMJ (1994)

inconsistent and erratic supply of insulin.Because insulin dependence in diabetes implies lifelong dependence, a regular and consistent supply of insulin is needed.The International Diabetes Federation has always advocated that insulin should be freely available to all those who need it, while a recently published report from a World Health Organisation study group states: "In all countries, the availability of insulin as an essential life-saving drug should be ensured, without imposition of taxes or restrictions regarding the transfer of technology for its manufacture."7Problems with the supply of insulin in the developing world have been reported anecdotally for many years.Recently three reports have highlighted the problem.In
Lymphangiomyomatosis recurrence in the allograft after single-lung transplantation.
Authors: J D O'Brien, J H Lium, J F Parosa, B R Deyoung, M R Wick, E P Trulock
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

The evolution of lung transplantation has offered an additional treatment option for patients with a variety of end-stage lung diseases, including some with systemic disorders. Lymphangiomyomatosis (LAM) is a multisystem disease of premenopausal women. The lung is the most frequently involved vital organ, and respiratory failure is the most common case of death. A small number of patients with LAM have undergone lung transplantation. This report describes a case of recurrent LAM in the allograft after single lung transplantation and discusses the implications of this finding.
Minisondes d'échoendoscopie pour le staging des lésions néoplasiques superficielles de l'oesophage: une série de 123lésions
Authors: M Chemaly, O Scalone, G Durivage, B Napoleon, B Pujol, C Lefort, V Hervieu, JY Scoazec, JC Souquet, T Ponchon
Journal: Endoscopy (2007)

Le traitement endoscopique exclusif des cancers superficiels de l'œsophage n'est indiqué qu'en l'absence de risque d'envahissement lymphatique et ne concerne donc que les cancers n'envahissant pas la sous-muqueuse. L'emploi de minisondes d'échoendoscopie pour le staging des lésions néoplasiques superficielles oesophagiennes avant mucosectomie reste controversé car les données hors séries japonaises sont faibles. Nous avons évalué dans une étude rétrospective, la précision de l'examen par minisonde à haute fréquence pour la détection de l'invasion de la sous-muqueuse par des lésions néoplasiques oesophagiennes.
233. Conjugating Polymer Vector to Magnetic Nanobeads Enhances Local Gene Expression in the Heart
Authors: Wenzhong Li, Nan Ma, Leelee Ong, Alexander Kaminski, Peter Lorenz, Brigitte M. Putzer, Ren-Ke Li, Christof Stamm, Gustav Steinhoff
Journal: Molecular Therapy (2006)

Statement of Purpose: The gene delivery efficacy is mainly limited due to the retention problem of non-viral vector-gene complexes in cardiovascular system. In this study, polymer vector- gene complexes were conjugated to magnetic nanobeads (MNB); MNB/Polymer/DNA complexes were guided to the targeted area via external magnetic fields, and induced localized marker and therapeutic genes over expression after intravenous administration.
Rapidly Enlarging Nodule on the Scalp
Authors: Whitney Pollard, James Pehoushek
Journal: JAMA Dermatology (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
THE ACUTE EFFECTS OF EXERCISE ON POST-EXERCISE INFLAMMATION AND IRON REGULATION: A COMPARISON BETWEEN TRAINED AND UNTRAINED MEN
Authors: KA Zwygart, C Howe, HJ Moir
Journal: British Journal of Sports Medicine (2013)

This study examined whether the magnitude of the effects of an exercise bout on inflammatory markers and iron regulation in humans differs between trained and untrained men. Changes in cell count (red blood cell, white blood cell, haemoglobin, haematocrit, lymphocytes, monocytes, granulocytes) Interleukin-6 (IL-6) and serum iron in response to a running bout were compared between both groups. Seven untrained (VO2max 47.4±4.1 ml·kg −1 ·min −1 ) and seven trained (56.9±4.5 ml·kg −1 ·min −1 ) men aged 19–48 years completed a Bruce protocol treadmill test and a subsequent treadmill run (45 min at 75% of VO 2max ). Ethical approval was granted by Kingston University Faculty Ethics Committee and conducted in accordance to the Declaration of Helsinki. Venous whole blood was collected before, and at 0, 3, 6 and 24 after exercise. Exercise-induced plasma volume changes were accounted for. Mixed Model ANOVA was performed to examine differences within groups. Independent t-tests identified which time points differed between groups, and dependent t-tests were applied to examine changes within groups over time. Significance was accepted at P &lt;0.05. Differences between groups were observed for haemoglobin ( P &lt;0.005) and red blood cell ( P =0.007) at all time points, as well as for haematocrit at all time points except at baseline ( P =0.013). Lymphocytes, Monocytes, Granulocytes, IL-6 and iron levels did not differ between groups. IL-6 levels were increased post-exercise in both groups, and iron was different 3 h post-exercise to 6 h post-exercise ( P &lt;0.05). Findings suggest haemoglobin, haematocrit and red bloods to be lower in trained individuals due to adaptations of endurance training. The single exercise running bout elicited an acute inflammatory response represented by an increase in IL-6 and decrease in serum iron. Alterations in IL-6 were not different between trained and untrained men, indicating a lack of effect of training status.
Initial Experience with Laparoscopic Ultrasound-Guided Radiofrequency Thermal Ablation of Hepatic Tumours
Authors: None Cuschieri, None Bracken, None Boni
Journal: Endoscopy (1999)

Background and Study Aims: Radiofrequency (RF) thermal ablation has been applied almost exclusively through the percutaneous approach under radiological/external ultrasound guidance. We have embarked on a programme of laparoscopic ultrasound-guided RF ablation of hepatic tumours in view of the potential advantages of this approach, i. e. reduced heat sink effect, greater precision and improved assessment of the thermal ablative zone.
The Pineal Gland
Authors: Richard Relkin
Journal: New England Journal of Medicine (1966)

THE purpose of this review is to summarize the known functions of the pineal gland. Then, utilizing recent evidence linking the visual and limbic systems, a hypothesis will be advanced concerning interrelations that the limbic system may have with the pineal gland.Pineal GlandIt has long been known that in fishes, amphibians and lacertilian reptiles, the pineal gland is primarily a photoreceptor organ,1 in which distinct sensory cells resembling retinal cone cells are found. In the frog the gland appears to be a wavelength discriminator that converts light energy of certain wavelengths into nervous impulses. However, in mammals there . . .
Alterations in appendicular skeletal mass in patients with rheumatoid, psoriatic, and osteoarthropathy.
Authors: C Cooper, V Poll, M McLaren, S O Daunt, M I Cawley
Journal: Annals of the Rheumatic Diseases (1988)

Appendicular bone mass was measured in a series of 50 patients with non-steroid treated rheumatoid arthritis, 20 with polyarticular seronegative psoriatic arthritis, and 30 with osteoarthrosis, and compared with that of 40 controls of similar age and sex. Distal forearm bone mineral content was reduced in patients with rheumatoid and psoriatic arthritis and increased in those with osteoarthrosis. The increase in bone mass in patients with osteoarthrosis was confined to those with isolated large joint disease and was not found in those with primary generalised osteoarthrosis.
Cross-priming CD8+ T cells by targeting antigens to human dendritic cells through DCIR
Authors: Eynav Klechevsky, Anne-Laure Flamar, Yanying Cao, Jean-Philippe Blanck, Maochang Liu, Amy O'Bar, Olivier Agouna-Deciat, Peter Klucar, LuAnn Thompson-Snipes, Sandra Zurawski, Yoram Reiter, A. Karolina Palucka, Gerard Zurawski, Jacques Banchereau
Journal: Blood (2010)
Association of genetic polymorphisms in CYP2E1, MPO, NQO1, GSTM1, and GSTT1 genes with benzene poisoning.
Authors: Junxiang Wan, Jinxiu Shi, Lijian Hui, Dan Wu, Xipeng Jin, Naiqing Zhao, Wei Huang, Zhaolin Xia, Gengxi Hu
Journal: Environmental Health Perspectives (2002)

Metabolic enzymes involved in benzene activation or detoxification, including NAD(P)H, quinone oxidoreductase 1 (NQO1), cytochrome P450 2E1 (CYP2E1), myeloperoxidase (MPO), glutathione-S-transferase mu-1 (GSTM1), and glutathione-S-transferase theta-1 (GSTT1), were studied for their roles in human susceptibility to benzene poisoning. The potential interactions of these metabolic enzymes with lifestyle factors such as cigarette smoking and alcohol consumption were also explored. We studied 156 benzene-poisoning patients and 152 workers occupationally exposed to benzene in South China. Sequencing, denaturing HPLC, restriction fragment-length polymorphism, and polymerase chain reaction were used to detect polymorphisms on the promoters and complete coding regions of NQO1, CYP2E1, MPO, and the null genotypes of GSTM1 and GSTT1. Seventeen single nucleotide polymorphisms (SNPs) were identified in NQO1, CYP2E1, and MPO genes, including 6 novel SNPs in CYP2E1 and MPO. Of the subjects who smoked and drank alcohol, an 8.15-fold [95% confidence interval (CI), 1.43-46.50] and a 21.50-fold (95% CI, 2.79-165.79) increased risk of benzene poisoning, respectively, were observed among the subjects with two copies of NQO1 with a C-to-T substitution in cDNA at nucleotide 609 (c.609 C>T variation; i.e., NQO1 c.609 T/T) compared to those with the heterozygous or wild (NQO1 c.609 C/T and c.609 C/C) genotypes. Our data also indicated that individuals with CYP2E1 c.-1293 C/C and c.-1293 G/C, and NQO1 c.609 T/T, and GSTT1 null genotypes tended to be more susceptible to benzene toxicity. Our results suggest that the combined effect of polymorphisms in NQO1, CYP2E1, and GSTT1 genes and lifestyle factors might contribute to benzene poisoning.
Lypressin nasal spray. Usefulness in patients who manifest allergies to other antidiuretic hormone preparations
Authors: N. Mimica
Journal: JAMA (1968)

Three patients with diabetes insipidus manifested allergic reactions to various antidiuretic hormone preparations of animal origin. After using vasopressin (Pitressin) tannate in oil, one patient had an extensive skin eruption and another had marked tenesmus and constipation. The third patient had allergic rhinitis and asthma after using posterior pituitary snuff. In all three patients, the use of lypressin (lysine-8-vasopressin) led to good control of their diabetes insipidus, and its use was not attended by any allergic symptoms or other side effects.
Delayed Hyper-Enhancement Magnetic Resonance Imaging Provides Incremental Diagnostic and Prognostic Utility in Suspected Cardiac Amyloidosis
Authors: Bethany A. Austin, W.H. Wilson Tang, E. Rene Rodriguez, Carmela Tan, Scott D. Flamm, David O. Taylor, Randall C. Starling, Milind Y. Desai
Journal: JACC. Cardiovascular imaging (2009)
Training in medical emergencies
Authors: C A Graham
Journal: BMJ (1994)

Analyses of this kind are beset by problems of colinearity, particularly of variables pertaining to practice organisation."Female partner in the practice" is the only such variable entered into the multiple regression model of Majeed and colleagues.This variable is, by virtue of its construction, highly correlated with partnership size.Our data suggest that both these variables have an independent effect of similar magnitude.
COMBINED ANTERIOR PITUITARY AND NEUROHYPOPHYSEAL INSUFFICIENCY. STUDIES OF BODY FLUID SPACES AND RENAL FUNCTION*
Authors: M. Mencer Martin
Journal: Journal of Clinical Investigation (1959)

Lesions of the neurohypophysis resulting in deficiency of antidiuretic hormone (ADH) produce the clinical syndrome of diabetes insipidus, provided the anterior pituitary is functionally in- tact.If the anterior lobe is destroyed, manifestations of diabetes insipidus may not appear (1-3).The administration of cortisone or adrenocorticotropin (ACTH) to patients with anterior pituitary insufficiency led to the recognition of coexisting -nPti1nrnkvnnn'k,%cPn1 fn;l1vtr, (_7\ Thke ^wosn f in that it approaches a condition in which the role of the kidney may be investigated in the human independent of hormonal control.The present study is an attempt at evaluating water metabo- lism and certain aspects of renal function in two patients with combined anterior pituitary and neurohypophyseal lesions.CASE REPORTS slculcUlhpupilyneal lallUct is of ph.soo such combined defects is of physiolog 8-6-URINE FLOW mi./min.
GW25-e3514 Resveratrol Alleviates Diabetic Cardiomyopathy through Improvement of Mitochondrial Biogenesis and Function in a SIRT1-dependent Manner
Authors: Ma Sai, Han Dong, Chen Jiangwei, Li Xiujuan, Guo Tao, Cao Feng
Journal: Journal of the American College of Cardiology (2014)
Aortic Rupture After a Minor Fall in a Patient with Extreme Cardiomegaly
Authors: Willard Aronson
Journal: JAMA (1963)

IT IS THE PURPOSE of this paper to report a most unusual case of traumatic rupture of the aortic root. Rupture of the normal aorta in the regions of the root and of the ligamentum arteriosum has been observed frequently after severe falls and blunt thoracic trauma,<sup>1,2</sup>and traumatic ruptures of aortic aneurysms are occasionally seen. However, this case was unique in that the fall was of relatively minor severity; the aorta was free of intrinsic disease, and there was a remarkable degree of cardiomegaly. <h3>Report of a Case</h3> The patient, a 64-year-old white male, had been known to have aortic insufficiency since March, 1956. At that time he was hospitalized because of an accidental head injury at work, a fracture of the petrous portion of the left temporal bone. He was found to have aortic insufficiency, apparently due to rheumatic heart disease. The serologic test for syphilis was