tbuckley/cabot-search huggingface dataset:
Comparison between apexcardiographic and angiographic indexes of left ventricular performance in patients with aortic incompetence.
Authors: J Manolas, H P Krayenbuehl
Journal: Circulation (1978)

Left ventricular (LV) apexcardiogram (ACG) and its first derivative (dA/dt) was obtained in 104 normal subjects and 34 patients with chronic aortic incompetence (AI). In the patients with AI the ACG was recorded simultaneously with LV pressure (tipmanometer). The systolic upstroke time (SUT), the time to peak dA/dt (t-dA/dt) and the a wave percentage amplitude (a/H) of the ACG was measured. In normal subjects SUT averaged 99 +/- 17 (SD) msec. In 17 patients with AI and normal ejection fraction (EF) (group 1) SUT was within normal limits; in 17 patients with AI and decreased EF (group 2) it was prolonged (142 +/- 19 msec) (P less than 0.001). The SUT was closely correlated with EF (r = 0.85) and less with contractile indexes derived from pressure curves. The indexes t-dA/dt and a/H were not significantly different in groups 1 and 2; they were weakly correlated only with the time to peak rate of LV pressure rise (r = +0.56) and the LV end-diastolic pressure (r = +0.59), respectively. These results demonstrate the superiority of SUT over the other apexcardiographic parameters. The measure provides another means of noninvasive assessment of the LV performance in patients with AI.
SPLENECTOMY BEFORE BONE MARROW TRANSPLANTATION IN CHRONIC GRANULOCYTIC LEUKAEMIA
Authors: MiguelA. Sanz, Guillermo Sanz, Ignacio Lorenzo, Hervé Tilly, Dominique Bastit, Jean-Paul Dauce, Mathieu Monconduit, Hubert Piguet
Journal: The Lancet (1986)
The Na, K-ATPase in the failing human heart
Authors: Robert H G Schwinger, Henning Bundgaard, Jochen Müller-Ehmsen, Keld Kjeldsen
Journal: Cardiovascular Research (2003)

The Na, K-ATPase consists of α- and β-subunits and actively transports Na out and K into the myocyte. It is the receptor for cardiac glycosides exerting its positive inotropic effect by inhibiting enzyme activity, decreasing the driving force for the Na/Ca-exchange and increasing cellular content and release of Ca during depolarization. The specific binding capacity for cardiac glycosides is utilized as a tool for Na, K-ATPase quantification with high accuracy and precision. In treatment of patients with heart failure cardiac glycosides improve symptoms and reduce the need for hospitalization without affecting mortality. In endomyocardial biopsies from patients with compromised cardiac function total Na, K-ATPase concentration is decreased by ∼40% and a correlation between decrease in heart function and decrease in Na, K-ATPase concentration exists. At the subunit level, the α1-, α3- and β1-proteins are reduced in human heart failure. During digitalization ∼30% of remaining Na, K-pumps are occupied by digoxin. Thus, a total of not less than half the Na, K-pumps may be out of function in the myocardium of digitalised heart failure patients. It is still a matter of debate whether a digitalis-like factor exists. There is a pressing need for the identification of its precise chemical structure, properties and quantitative relation to the Na, K-ATPase. It is recommended that cardiac glycosides are prescribed to heart failure patients who are still having heart failure symptoms after institution of mortality reducing therapy. Cardiac glycoside treatment is still the only safe inotropic drug for oral use that improves hemodynamics in patients with compromised cardiac function.
General Paralysis Occurring about the Period of Puberty
Authors: J. Wiglesworth
Journal: BMJ (1893)

IMDcLJORA 3ing.Her weakness gradually increaled so that she could only walk with difficulty, and she used to fall down in the street witlhout any warning, and when down could not get up until assisted.The symptoms vary a little in degree every few days, but on the whole have gradually got worse and have never at any time completely disappeared.About eighteen months ago, while singing, her tongue became paralysed and she could not articulate distinctly, and about twelve months ago she had difficulty in swallowing, and liquids came down her nose.Five months ago suffocative attacks supervened.There was no history of diphtheria.On examining the eyes it was found that there was slight ptosis on both sides, and that the movements of the eyeballs were sluggish, and restricted in all directions, especially upwards.The right eye could not be turned upwards at all, and forced movement in any direction was attended with nystagmus; diplopia was present at times.The field of vision when the lids were raised was normal.The pupils were equal. of normal size, and responded to light and accommodation perfectly.The fundus oculi was normal on each side.She could not close her eyes tightly, and fibrillary tremor of the orbicularis muscle occurred when she tried to do so.She complained of food collecting between the gums and teeth, and that her tongue was weak.Her speech was a little indistinct.more especially after talking for a few moments.She complained also of difflculty in swallowing, but no paralysis of the soft palate could be dis- covered, and the palatal reflex was present.Mastication was impaired from loss of muscular power.The arms could not be lifted from the shoulders, the deltoids were large, and all the other muscles appeared normally developed, there were no sensory changes, no exaggeration of reflexes.and no electrical changes.The spinal museles were very weak, the patient being unable to sit up without assistance, and when sup- ported on her feet marked lordosis was present.She raised herself from the sitting position by placing her hands on the chlair, and did so with great difficultv.When lying down she could not get up at all without assistance.Her legs were also very weak, for she could not lift them iroin the bed.Her gait was slightly waddling, and she would have fallen without support.The knee-jerk wvas a little increased, but there was no ankle clonus ; the plantar reflexes were usually absent.There were no sensory changes, but the hands and feet were cold and blue.The patient was admitted into the Queen's Hospital for further observation.It was
JOURNALS FOR OTHER COUNTRIES
Authors: Claude H. Castle
Journal: JAMA (1953)

<h3>To the Editor:</h3> —The returns from my letter published inThe Journal(<b>150:</b>814 [Oct. 25] 1952) offering to send medical periodicals to foreign physicians have been gratifying but rather surprising. I had expected the bulk of the requests to come from Great Britain and the Continent, but I received only one from England, one from France, and one from Germany. That the other requests came from many other cities around the world certainly speaks well for the distribution ofThe Journal. I had several requests from foreign physicians residing in the United States, but, since the postmarks on their letters seemed to indicate that they would have access to medical libraries, I referred them to those facilities. There were two requests from institutions, one of which was the Severance Hospital and School in Seoul, Korea; however, a letter inThe Journal(<b>151:</b>319 [Jan. 24] 1952) should be sufficient
Assessment of Serum ADMA Levels and Aortic Elastic Properties in Patients With Ankylosing Spondilitis
Authors: Hasan Kaya, Ebru Öntürk Tekbaş, Faruk Ertaş, Ümit İnci, Mustafa Oylumlu, Murat Yüksel, Mesut Aydın, İbrahim Batmaz, Hatice Yüksel, Mehmet Sıddık Ülgen
Journal: Journal of the American College of Cardiology (2013)
Medical compared with surgical management of unstable angina. 5-year mortality and morbidity in the Veterans Administration Study.
Authors: A F Parisi, S Khuri, R H Deupree, G V Sharma, S M Scott, R J Luchi
Journal: Circulation (1989)

We evaluated medical in comparison to surgical plus medical (surgical) treatment of unstable angina using a prospective randomized protocol that stratified patients by clinical presentation and by invasive evaluation of left ventricular (LV) function. Clinical presentations were as follows--type 1: progressive or new onset angina relieved by medication; type 2: prolonged bouts of angina poorly or incompletely relieved by medication. Abnormal LV function was arbitrarily defined as ejection fraction less than 0.50 or LV end-diastolic pressure 16 mm Hg or more. Of 468 patients, 237 were assigned to medical and 231 to surgical therapy. There were 374 type 1 and 94 type 2 patients. LV function was normal in 334 and abnormal in 134 patients. Compared with results at 24 months, this 60-month follow-up study showed important differences in survival for patients with three-vessel disease: 75% for medical and 89% for surgical patients (p less than 0.02). The cumulative 5-year rate of repeat hospitalizations for cardiac reasons was less with surgical patients for either clinical presentation. For type 1, medical patients had a 56% rate, and surgical patients had a 42% rate (p = 0.004). For type 2, medical patients had a 62% rate, and surgical patients had a 43% rate (p = 0.05). Overall mortality did not differ between the two treatments, and this remained true in type 1 versus type 2 patients and in those with normal versus abnormal LV function. However, regression analysis of medical and surgical groups with ejection fraction as a continuous variable showed that mortality of medical patients depended on ejection fraction (p = 0.004), whereas the mortality of surgical patients did not (p = 0.76), and survival in the surgical group was higher in the lowest ejection fraction tercile-73% for medical and 86% for surgical patients, p = 0.03. We conclude that surgery improves survival in patients with three-vessel disease and leads to fewer subsequent hospitalizations for cardiac reasons. An impaired ejection fraction had an adverse impact on survival of medical patients but not on surgical patients, and mortality in surgical patients was improved compared with medical patients in the lowest ejection fraction tercile.
Diapers and Day Care
Authors: Richard Scribner
Journal: JAMA (1991)

<h3>To the Editor.</h3> —The "randomized trial" by Van et al<sup>1</sup>of diaper type in a day-care center is fundamentally flawed because vital information on potential biases has been omitted. Thus, the missing information should be requested from the authors and provided to the<i>JAMA</i>readership. In the study, the authors used a randomized, cross-over design. Presumably, the design was chosen to yield a definitive study of diaper type in the day-care setting. Instead, they chose to treat diapering like taking a drug. However, a "gold-standard" design for clinical trials is subject to significant biases in the social setting of the day-care environment. First, the care givers were not blinded, raising the question of what was the diaper preference of each of the care givers prior to the study. The authors gave no information on this fundamental point and did not mention it as a potential bias. It is up
Keratin 8 Mutations in Patients with Cryptogenic Liver Disease
Authors: Nam-On Ku, Robert Gish, Teresa L. Wright, M. Bishr Omary
Journal: New England Journal of Medicine (2001)

About 10 percent of patients who undergo liver transplantation have cryptogenic liver disease. In animal models, the absence of heteropolymeric keratins 8 and 18 or the presence of mutant keratins in hepatocytes causes or promotes liver disease. We have previously described a mutation in the keratin 18 gene in a patient with cryptogenic cirrhosis, but the importance of mutations in the keratin 8 and keratin 18 genes in such patients is unclear.
Spitting out the tongue
Authors: G. Obermoser, L. Posch, B. Zelger
Journal: British Journal of Dermatology (2004)

Journal Article Spitting out the tongue Get access G. Obermoser, G. Obermoser Departments of Dermatology and Vascular Surgery, University Hospital of Innsbruck, Anichstrasse 35, Innsbruck, Austria G.Obermoser. E‐mail: gerlinde.obermoser@uibk.ac.at Search for other works by this author on: Oxford Academic Google Scholar L. Posch, L. Posch Departments of Dermatology and Vascular Surgery, University Hospital of Innsbruck, Anichstrasse 35, Innsbruck, Austria Search for other works by this author on: Oxford Academic Google Scholar B. Zelger B. Zelger Departments of Dermatology and Vascular Surgery, University Hospital of Innsbruck, Anichstrasse 35, Innsbruck, Austria Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 151, Issue 3, 1 September 2004, Pages 721–722, https://doi.org/10.1111/j.1365-2133.2004.06161.x Published: 01 September 2004
'I'm Worried'
Authors: Irwin M. Siegel
Journal: JAMA (1982)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Relation of urinary cotinine concentrations to cigarette smoking and to exposure to other people's smoke.
Authors: P N Lee
Journal: Thorax (1991)

Relation of urinary cotinine concentrations to cigarette smoking and to exposure to other people's smoke Dr Simon Thompson and his colleagues measured urinary cotinine in 184 self repor- ted non-smokers (May 1990;45:356-61).Taking 10-30% of average smokers' concen- trations to indicate occasional smoking and over 30% to indicate regular smoking, they found two (1-1%) occasional smokers and no regular smokers among their non-smokers.
UK government bans sale of beef on the bone
Authors: J. Warden
Journal: BMJ (1997)

New restrictions on beef to keep bovine spongiform encephalopathy (BSE) out of the food chain are being imposed by the British government in response to fresh scientific evidence of infectivity. Tissue of the dorsal root ganglia within the spinal column is now suspect. As a result, a ban will be imposed on beef sold “on the bone,” such as T bone steaks.

In addition, the government is considering a public inquiry into the whole BSE episode, going back to the early 1980s, when British cattle were fed sheep protein probably contaminated by scrapie. …
Ascorbic Acid Administration and Urinary Oxalate
Authors: C.S. TSAO
Journal: Annals of Internal Medicine (1984)

Letters and Corrections1 September 1984Ascorbic Acid Administration and Urinary OxalateC.S. TSAO, PH.DC.S. TSAO, PH.DSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-101-3-405_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Recently, Swartz and associates (1) have reported the case of a patient with hyperoxaluria and renal insufficiency related to ascorbic acid administration during total parenteral nutrition.During the last 11 years, we have been receiving increasing numbers of questions on the effect of large intake of ascorbic acid on the excretion of oxalic acid. Some reports in the literature have suggested that daily ingestion of gram quantities slightly or severely increased oxalic acid excretion in healthy persons and also in patients with urolithiasis. Other reports have stated that urinary oxalate excretion of healthy persons or those with...References1. SWARTZ R, WESLEY J, SOMERMEYER M, and LAU K. Hyperoxaluria and renal insufficiency due to ascorbic administration during total parenteral nutrition. Ann Intern Med. 1984;100:530-1. LinkGoogle Scholar2. FITURI N, ALLAWI N, BENTLEY M, and COSTELLO J. Urinary and plasma oxalate during ingestion of pure ascorbic acid: a re-evaluation. Eur Urol. 1983;9:312-5. CrossrefMedlineGoogle Scholar3. HODGKINSON A and WILLIAMS A. An improved colorimetric procedure for urine oxalate. Clin Chim Acta. 1982;36:127-32. CrossrefGoogle Scholar4. TSAO C. Effect of large intake of ascorbic acid on urinary and plasma oxalic acid levels. Int J Vitam Nutr Res. 1984. (In press). MedlineGoogle Scholar5. HOFFER A. Vitamin C and infertility. Lancet. 1973;2:1146. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: C.S. TSAO, PH.D PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byProtocol for the use of vitamin C in the treatment of cancer 1 September 1984Volume 101, Issue 3Page: 405-406KeywordsExcretionIngestionTotal parenteral nutrition ePublished: 1 December 2008 Issue Published: 1 September 1984 PDF downloadLoading ...
Mortality From Ischemic Heart Disease
Authors: Terence W. Anderson
Journal: JAMA (1973)

There has been a large and unequivocal rise in the death rate from ischemic heart disease in middle-aged US white men since the beginning of this century. Uncertainty caused by changing terminology has been minimized by working with the ratio of the male to female death rates. In the age group 45 to 64, the ratio of the male to female death rates from all types of heart disease rose from 1.1 in 1920 to 3.3 in 1968. By 1968 the all-cause male death rate had risen to more than double the female rate (ratio 2:1) compared to only a 10% male excess in 1920.
Effect of the Synthetic Retinoid Fenretinide on Dark Adaptation and the Ocular Surface
Authors: A. Decensi, R. Torrisi, A. Polizzi, R. Gesi, V. Brezzo, M. Rolando, G. Rondanina, M. AntoniettaOrengo, F. Formelli, A. Costa
Journal: JNCI Journal of the National Cancer Institute (1994)

Journal Article Effect of the Synthetic Retinoid Fenretinide on Dark Adaptation and the Ocular Surface Get access Andrea Decensi, Andrea Decensi Department of Medical Oncology II, National Institute for Cancer ResearchGenoa, Italy Correspondence to : Andrea Decensi, M.D., Servizio di Oncologia Medica II, Istituto Nazionale per la Ricerca sul Cancro, Viale Benedetto XV, 10 – 16132 Genoa, Italy. Search for other works by this author on: Oxford Academic PubMed Google Scholar Rosalba Torrisi, Rosalba Torrisi Department of Medical Oncology II, National Institute for Cancer ResearchGenoa, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar Anna Polizzi, Anna Polizzi University Institute of OphthalmologyGenoa Search for other works by this author on: Oxford Academic PubMed Google Scholar Roberta Gesi, Roberta Gesi University Institute of OphthalmologyGenoa Search for other works by this author on: Oxford Academic PubMed Google Scholar Valeria Brezzo, Valeria Brezzo University Institute of OphthalmologyGenoa Search for other works by this author on: Oxford Academic PubMed Google Scholar Maurizio Rolando, Maurizio Rolando University Institute of OphthalmologyGenoa Search for other works by this author on: Oxford Academic PubMed Google Scholar Gabriella Rondanina, Gabriella Rondanina Department of Medical Oncology II, National Institute for Cancer ResearchGenoa, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar Maria AntoniettaOrengo, Maria AntoniettaOrengo Department of Biostatistics, National Institute for Cancer ResearchGenoa, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar Franca Formelli, Franca Formelli National Tumor Institute MilanItaly Search for other works by this author on: Oxford Academic PubMed Google Scholar Alberto Costa Alberto Costa National Tumor Institute MilanItaly Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 86, Issue 2, 19 January 1994, Pages 105–110, https://doi.org/10.1093/jnci/86.2.105 Published: 19 January 1994 Article history Received: 29 June 1993 Accepted: 19 October 1993 Published: 19 January 1994
Identification of distinct upper and lower gastrointestinal symptom groupings in an urban population
Authors: N J Talley, P Boyce, M Jones
Journal: Gut (1998)

The current classification dividing patients with functional gastrointestinal symptoms into subgroups remains controversial.To determine whether distinct symptom groupings exist in the community.A random sample of Sydney residents in Penrith, Australia was mailed a validated self report questionnaire. Gastrointestinal symptoms including the Rome criteria for irritable bowel syndrome (IBS) and dyspepsia were measured.Among 730 respondents, the 12 month age and gender adjusted prevalence (adjusted to the Australian population) of IBS, dyspepsia, and gastro-oesophageal reflux were 11.8% (95% confidence interval (CI) 9.3 to 14.3%), 11.5% (95% CI 9.6 to 14.6%), and 17.5% (95% CI 14.2 to 19.9%), respectively. In total, 60% of the population reported four or more gastrointestinal symptoms. There was considerable overlap of IBS with dyspepsia and among the dyspepsia subgroups by application of the Rome criteria. Independently, 10 symptom groupings were identified by factor analysis. The underlying constructs measured by these factors were generally the major abdominal syndromes recognised by the Rome classification: dyspepsia, IBS, reflux, painless constipation, painless diarrhoea, and bloating, in addition to a number of more specific symptom groupings.Gastrointestinal symptoms are common and overlap in the community, but distinct upper and lower abdominal symptom groupings can be identified.
De novo oligoclonal expansions of circulating plasmablasts in active and relapsing IgG4-related disease
Authors: Hamid Mattoo, Vinay S Mahajan, Emanuel Della-Torre, Yurie Sekigami, Mollie Carruthers, Zachary S Wallace, Vikram Deshpande, John H Stone, Shiv Pillai
Journal: Journal of Allergy and Clinical Immunology (2014)