tbuckley/cabot-search huggingface dataset:
Tardive dyskinesia and informed consent
Authors: J. Schnee
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Rapid and Simple Platelet Function Assay to Assess Glycoprotein IIb/IIIa Receptor Blockade
Authors: Barry S. Coller, Daniel Lang, Lesley E. Scudder
Journal: Circulation (1997)

Background The platelet glycoprotein (GP) IIb/IIIa receptor antagonist c7E3 Fab (abciximab; ReoPro) has been approved as an antithrombotic agent, and other GP IIb/IIIa antagonists, including oral agents, are under development. At present, there are no rapid and simple assays to monitor GP IIb/IIIa receptor blockade. Methods and Results An assay was devised based on the ability of platelets in whole blood to rapidly agglutinate fibrinogen-coated beads when stimulated with a peptide, (iso-S)FLLRN, that activates a platelet thrombin receptor but resists inactivation by plasma aminopeptidase M. Preincubation of normal blood with increasing concentrations of c7E3 Fab led to increasing inhibition of the assay, correlating with increased GP IIb/IIIa receptor blockade. Assay conditions were chosen so that agglutination was inhibited at 2 minutes when &gt;82% of the receptors were blocked. Similar results were obtained with the use of GP IIb/IIIa antagonists based on the arginine-glycine-aspartic acid (RGD) cell-recognition sequence. Conclusions A simple and rapid assay sensitive to GP IIb/IIIa receptor blockade has been developed that may be helpful in optimizing GP IIb/IIIa antagonist therapy.
Exercise Intensity and Longevity in Men-Reply
Authors: Ralph S. Paffenbarger
Journal: JAMA (1995)

<h3>In Reply.</h3> —Drs Pahor and Carbonin query our use of different classification criteria in analysis of physical activity and longevity in a cohort of Harvard alumni. We used three schemes for categorizing physical activity: (1) increments of 2100 kJ/wk; (2) quintiles of total energy expenditures (&lt;2524, 2524 to &lt;4738, 4738 to &lt;8001, 8001 to &lt;13142, and &gt;13142 kJ/wk), and (3) five categories each of vigorous and nonvigorous energy expenditure, using identical cutoffs (&lt;630, 630 to &lt;1680, 1680 to &lt;3150, 3150 to &lt;6300, and &gt;6300 kJ/wk). Since vigorous and nonvigorous energy expenditure add up to total energy expenditure, the cutoffs for category 3 are, of course, lower than those for category 2. Ideally, we would have used category 1 for all analyses; however, using increments of 2100 kJ/wk led to small numbers of deaths (&lt;50) within some categories (Table 2). Thus, for age-adjusted analysis, stable estimates for mortality rates could be
Warfarin, Genes, and the (Health Care) Environment
Authors: Dhruv S. Kazi, Mark A. Hlatky
Journal: JAMA Internal Medicine (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Invisible Risks, Emotional Choices — Mammography and Medical Decision Making
Authors: Lisa Rosenbaum
Journal: New England Journal of Medicine (2014)

A child's risk of getting cancer from asbestos insulation in a school building is about one third the chance of being struck by lightning. Nevertheless, in 1993, frightened New York City parents agitated for asbestos removal from schools. As often occurs, public fear trumped expert risk assessment; the parents' demands were met, the victory was celebrated, but then the celebration crashed. It turned out that removing the asbestos would mean closing the schools for weeks, disrupting parents' lives. “As the costs of the removal came on-screen,” writes behavioral economist Cass Sunstein, “parents thought much more like experts, and the risks . . .
Role of gender in health disparity: the South Asian context
Authors: Fariyal F Fikree, Omrana Pasha
Journal: BMJ (2004)

South Asia's girls and women do not have the same life advantage as their Western counterparts. A human rights based approach may help to overcome gender related barriers and improve the wellbeing of men, women, and children. 

Behaviour has an important role in health disparities—for example, young men take greater risks, causing injury and violent death, and men smoke more.1 In industrialised countries women are born with an advantage; their healthy life expectancy is two years longer and their life expectancy six years longer than those of men.2 This advantage is prominent in childhood; girls are more likely to survive the first five years of life than boys.2 However, does this female advantage endure in parts of the world where gender discrimination exists? We present the case of South Asia to illustrate the role that gender has on health.

From many perspectives women in South Asia find themselves in subordinate positions to men and are socially, culturally, and economically dependent on them.3 Women are largely excluded from making decisions, have limited access to and control over resources, are restricted in their mobility, and are often under threat of violence from male relatives.4 Sons are perceived to have economic, social, or religious utility; daughters are often felt to be an economic liability because of the dowry system.5

We believe that individual and societal beliefs about and attitudes towards appropriate gender specific roles, and the choices of individuals and households on the basis of these factors, mean that women are disadvantaged with regard to health and health care. There are some instances in which gender differences hurt men's health—for example, men are more likely to be involved in road crashes or occupational accidents as they are more likely to be outside the home or in a …
Changes in the MRCP examination
Authors: E. Samuel
Journal: BMJ (1981)

Therapeutics Bulletins.7This recommendation was purely on the grounds that dextromoramide tablets are more convenient than morphine solution.However, morphine is now available in a 10 mg slow-release tablet formulation and therefore this point is no longer valid.Clinical experience in terminal care, both in Leeds and elsewhere,8-'0 has led us to conclude that dextromoramide is a less suitable analgesic than morphine, diamorphine, or phenazocine for the control of pain in terminal illness.
An association of candidate gene haplotypes and bleeding severity in von Willebrand disease (VWD) type 1 pedigrees
Authors: Thomas J. Kunicki, Augusto B. Federici, Daniel R. Salomon, James A. Koziol, Steven R. Head, Tony S. Mondala, Jeffrey D. Chismar, Luciano Baronciani, Maria Teresa Canciani, Ian R. Peake
Journal: Blood (2004)
Clinical tests in aquatic toxicology: state of the art
Authors: Paul M. Mehrle, Foster L. Mayer
Journal: Environmental Health Perspectives (1980)

Hazard assessment of chemicals to aquatic organisms involves the use of many toxicity tests. Acute toxicity tests, embryo-larval toxicity tests, and chronic toxicity tests that measure survival, growth, and reproductive effects now provide the most relative utility for evaluation of potential chemical hazards to aquatic life. Physiological, biochemical, and histological measurements have a low relative utility as diagnostic tests in aquatic toxicology because it is not yet possible to relate changes in these sublethal responses to adverse environmental impacts. The problem of interpreting the toxicological significance of chemical-induced changes in biochemical and physiological mechanisms is twofold: (1) the understanding of physiological and biochemical regulatory mechanisms in fish is limited; and (2) parallel changes in these mechanisms are difficult to correlate with toxicant exposure and impaired ability of fish to survive. To overcome this problem, more physiological and biochemical research must be conducted in conjunction with toxicity studies that measure important whole-animal responses. Toxicant-induced biochemical and physiological responses must be correlated unequivocally with responses related to reproduction, growth and development, survival, or fish health if pertinent diagnostic tests are to be developed for use in aquatic toxicology. The use of diagnostic tests in hazard assessment procedures can decrease the time required for safety evaluation of chemicals, define no-effect exposure concentrations more adequately, and provide a better understanding of the mode of action of chemicals. Considerations for improving the status of the “state of the art” of diagnostic or clinical tests in aquatic toxicology are discussed.
PRACTICAL VALUE OF BLOOD-CRYOSCOPY FOR THE DETERMINATION OF RENAL FUNCTION
Authors: M. KROTOSZYNER
Journal: JAMA (1913)

The first attempt to measure osmotic pressure of animal fluids through molecular concentration or by means of determining their freezing-points dates back about twenty years, when Dreser<sup>1</sup>in 1892 published the results of his investigations on diuresis as dependent on pharmacologic agents. His method, though, was too complicated for practical purposes. The merit of having established freezing-point determination as a definite clinical method of practical value belongs to A. von Koranyi<sup>2</sup>who, five years later, published his fundamental physiologic and clinical investigations on the determination of osmotic pressure of animal fluids by means of lowering their freezing-points. He was the first to show that the freezing-point of normal blood lies at about 0.56 C. below zero, and that blood taken from individuals with healthy kidneys shows a freezing-point varying between 0.55 and 0.58, while, through retention of end-products of metabolism and the thus resulting deterioration of renal function, a rise<sup>3</sup>
EMERGENCE OF TRIMETHOPRIM-RESISTANT ENTEROBACTERIA IN PATIENTS RECEIVING LONG-TERM CO-TRIMOXAZOLE FOR THE CONTROL OF INTRACTABLE URINARY-TRACT INFECTION
Authors: N.J. Pearson, AnneM. Mcsherry, K.J. Towner, W.R. Cattell, F. O'Grady
Journal: The Lancet (1979)
A new non-invasiv method for detection and assessment of aortic regurgitation during routine blood pressure recordings
Authors: Todd J. Brinton, Tsui-Lieh Hsu, Qi-Ling Kwan, Chun-Peng Liu, Mau Song Chang, Shiu-Shin Chio, Anthony N. DeMaria
Journal: Journal of the American College of Cardiology (1996)
Serum from patients with non‐hodgkin's lymphoma(nhl) inhibits T‐cell colony formation
Authors: Robert E. Hutchison, Diane G. Tice, Frederick R. Davey
Journal: American Journal of Hematology (1987)

Abstract This study compared T‐cell colony formation in soft agar of lymphocytes from the peripheral blood and lymph nodes of patients with non‐Hodgkin's lymphoma (NHL) with T‐cell colony formation of peripheral blood lymphocytes from normal individuals. Mononuclear cells were separated from other blood and lymph node elements on density gradient columns, phenotyped for T‐ and B‐cell antigens using monoclonal antibodies, and then plated in soft agar cultures. Lymphocytes from peripheral blood and lymph nodes of patients with NHL exhibited less T‐cell colony formation (p &lt; 0.01) than did lymphocytes from normal individuals. This decrease in T‐cell colony formation was not the result of the number of T cells or null cells plated, or differences in proportions of T helper and T suppressor cells. However, when sera from patients with NHL were incubated with normal lymphocytes before plating in soft agar, a decrease in number of T‐cell colonies was observed (p &lt; 0.01). We conclude that peripheral blood and lymph node mononuclear cells from patients with NHL have a decreased ability to form T‐cell colonies in soft agar cultures and that this decrease is related, at least in part, to the presence of serum factor(s).
Doctors' leaders back call for greater investment in NHS in England
Authors: G. Iacobucci
Journal: BMJ (2014)

Professional bodies have joined NHS leaders in calling for new investment from the next government to help safeguard the NHS, after the publication of a major national blueprint for healthcare in England.

The Five Year Forward View , published on 23 October by NHS England and other national bodies, called for substantial changes to service delivery and a radical expansion in preventive care in the next five years to help reduce a projected £30bn (€38bn; $48bn) funding shortfall.1 But the report estimated that the next government would also need to invest an additional 1.5% above inflation each year (around £8bn in total) to close the funding gap entirely.2

The BMA and medical royal …
Median-Nerve Neuropathy after Percutaneous Puncture of the Brachial Artery in Patients Receiving Anticoagulants
Authors: William L. Macon, J. William Futrell
Journal: New England Journal of Medicine (1973)

SUBFASCIAL bleeding after percutaneous puncture of the brachial artery in patients on anticoagulation therapy may lead to median-nerve neuropathy and Volkmann's contracture, if not recognized and treated promptly.Case 1. A 17-year-old girl was given heparin because of consumptive coagulopathy. Blood for blood gas determination was obtained from the right brachial artery. Within a few hours swelling and discoloration were noted in the right elbow and forearm region. The radial pulse was absent although the capillary return was normal. The patient was treated with reversal of anticoagulation and arm elevation. The radial pulse returned in 2 days. After recovery from . . .
THE RESPONSE OF THE SAWEAT GLANDS TO β-ADRENERGIC STIMULATION
Authors: J. A. WARNDORFF
Journal: British Journal of Dermatology (1972)

Summary.— Intracutaneous injections of isoprenaline gave a sweat response in 8 of 13 subjects. Injections of isoprenaline, together with an a-blocking agent, gave equal or higher sweat responses. The curves obtained suggested that the responses were mediated by acetylcholine. It is suggested that some clinical observations might reveal whether a p-adrenergic mechanism is possibly involved in the paradoxical sweat reactions of patients in shock, in hypoglycaemic patients and in patients with a phaeochromocytoma.
Global Surgery and Public Health: A New Paradigm
Authors: Thomas R. McLean
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 145: MicroRNA-361-3p functions as an oncogenic microRNA in human oral cancer cells
Authors: Hiroshi Tanaka, Koh-ichi Nakashiro, Ryota Oka, Yukiko Nishikawa, Hiroyuki Goda, Hiroyuki Hamakawa
Journal: Cancer Research (2011)

Abstract MicroRNAs (miRNAs) are small non-coding double-stranded RNA with sizes of 20-25 nucleotides, and inhibit protein translation by binding the 3'-untranslated region of target mRNA. Each miRNA can regulate multiple mRNAs and each mRNA can be targeted by a number of miRNAs. In cancer, miRNAs can act as not only tumor suppressor genes but also oncogenes (OncomiR). Most recent study has demonstrated OncomiR addiction in mouse pre-B-cell lymphoma. OncomiR addiction may also provide therapeutic opportunities in human cancers such as oncogene addiction. In this study, we have attempted to identify an OncomiR in human oral cancer cells through functional screening and considered whether targeting miRNA can be possible for cancer therapy. First, we performed functional screening for OncomiR in human oral cancer cells by the use of miRCURY LNATM microRNA Knockdown Library (Exiqon). We transfected 918 locked nucleic acid (LNA) antisense oligonucleotides for specific human mature miRNAs into human oral squamous cell carcinoma cells (GFP-SAS) and salivary gland cancer cells (GFP-ACCM). After transfection for 80 hours, each cell growth was evaluated. LNA antisense oligonucleotides against microRNA-361-3p (LNA-miR-361-3p) showed a remarkable growth inhibition in both types of cells as compared with non-targeting LNA oligonucleotides. We also observed the change of cell morphology, diminution of colony size, and a number of non-adherent cells after transfection of LNA-miR-361-3p. Subsequently, we examined the knockdown effect of LNA-miR-361-3p in GFP-SAS cells by quantitative RT-PCR. Compared with control oligonucleotides, the expression of miR-361-3p was significantly reduced by 71%. These effects of LNA-miR-361-3p were not observed by transfection of DNA or RNA antisense oligonucleotides for miR-361-3p. Next, we transfected synthetic human mature miR-361-3p into GFP-SAS cells to investigate the effect of miR-361-3p overexpression. Cell growth resulted in a significant 20% increase compared with non-targeting control miRNA. Furthermore, co-transfection of LNA-miR-361-3p and its decoy oligonucleotides abrogated the growth inhibitory effect by LNA-miR-361-3p in GFP-SAS cells. These results suggest that miR-361-3p functions as an OncomiR in human oral cancer cells and LNA antisense oligonucleotides are useful and efficient for silencing miRNA. Targeting miR-361-3p with LNA antisense oligonucleotides may be a useful therapeutic approach for patients with oral cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 145. doi:10.1158/1538-7445.AM2011-145
QUANTITATIVE AND COMPOSITIONAL DIFFERENCES IN CORONARY ATHEROMA IN PATIENTS WITH VS. WITHOUT DIABETES MELLITUS (DM), DETECTED IN VIVO VIA INTRAVASCULAR ULTRASOUND-VIRTUAL HISTOLOGY (IVUS-VH) PRIOR TO PERCUTANEOUS CORONARY INTERVENTION (PCI)
Authors: Sandeep Nathan, Linda Lee, Falak Shah, Sandra A. Weiss, Shashank Sinha, Adam Goldberg, John J. Lopez
Journal: Journal of the American College of Cardiology (2010)
Is Curative Endoscopic Treatment of Early Gastric Cancer Possible?
Authors: W. Imaoka, K. Ida, T. Katoh, J. Okuda, K. Kawai
Journal: Endoscopy (1987)

Fifty-four lesions found in 51 cases of early gastric cancer were treated with the Nd:YAG laser, N2 dye laser, local injection of ethanol, polypectomy and a combination of these methods between November, 1980 and July, 1986. Among these lesions, 34 were followed for more than one year with the endoscope.
Contribution of Relaxation Technique Training to the Rehabilitation of Myocardial Infarction Patients
Authors: J. van Dixhoorn, J. de Loos, H.J. Duivenvoorden
Journal: Psychotherapy and Psychosomatics (1983)

The usefulness of relaxation training (RT) in cardiac rehabilitation is assessed by comparing the changes before and after rehabilitation in two randomly divided groups, one with and the other without relaxation. The psychological effects of RT, in addition to the effects of exercise training, were studied. There is a substantial and positive result on well-being and on feelings of invalidity. Psychological improvement, as a result of exercise only, is not found. The benefits of RT occur more in persons with coronary-prone behavior pattern (type A). In some persons anxiety increases during rehabilitation (about 28%), regardless of RT. There is an indication that relaxation may lead to an increase of functional complaints in a small number of persons, possibly due to sensitization to bodily experiences.
Selective ablation of mast cells or basophils reduces peanut-induced anaphylaxis in mice
Authors: Laurent L. Reber, Thomas Marichal, Kaori Mukai, Yoshihiro Kita, Suzumi M. Tokuoka, Axel Roers, Karin Hartmann, Hajime Karasuyama, Kari C. Nadeau, Mindy Tsai, Stephen J. Galli
Journal: Journal of Allergy and Clinical Immunology (2013)