tbuckley/cabot-search huggingface dataset:
High prevalence of colorectal neoplasm in patients with non-alcoholic steatohepatitis
Authors: V. W.-S. Wong, G. L.-H. Wong, S. W.-C. Tsang, T. Fan, W. C.-W. Chu, J. Woo, A. W.-H. Chan, P. C.-L. Choi, A. M.-L. Chim, J. Y.-W. Lau, F. K.-L. Chan, J. J.-Y. Sung, H. L.-Y. Chan
Journal: Gut (2011)

<h3>Objective</h3> Non-alcoholic fatty liver disease (NAFLD) affects 20–40% of the general adult population. Due to shared risk factors, it is postulated that NAFLD patients have an increased risk of colorectal neoplasm and should be a target group for screening. The aim of this study was to examine the prevalence of colorectal neoplasm in NAFLD patients and the risk of colorectal neoplasm in relation to the severity of NAFLD histology. <h3>Design</h3> Cross-sectional study. <h3>Setting</h3> University hospital with case recruitment from the community and clinics. <h3>Patients</h3> Subjects aged 40–70 years were recruited for colonoscopic screening from two study cohorts: (1) community subjects; and (2) consecutive patients with biopsy proven NAFLD. In the community cohort, hepatic fat was measured by proton-magnetic resonance spectroscopy. <h3>Main outcome measures</h3> Prevalence of colorectal adenomas. Advanced colorectal neoplasm was defined as cancer or adenomas with villous architecture or high grade dysplasia. <h3>Results</h3> NAFLD patients (N=199) had a higher prevalence of colorectal adenomas (34.7% vs 21.5%; p=0.043) and advanced neoplasms (18.6% vs 5.5%; p=0.002) than healthy controls (N=181). Thirteen of 29 (45%) NAFLD patients with advanced neoplasms had isolated lesions in the right sided colon. Among patients with biopsy proven NAFLD, patients with non-alcoholic steatohepatitis (N=49) had a higher prevalence of adenomas (51.0% vs 25.6%; p=0.005) and advanced neoplasms (34.7% vs 14.0%; p=0.011) than those with simple steatosis (N=86). After adjusting for demographic and metabolic factors, non-alcoholic steatohepatitis remained associated with adenomas (adjusted OR 4.89, 95% CI 2.04 to 11.70) and advanced neoplasms (OR 5.34, 95% CI 1.92 to 14.84). In contrast, the prevalence of adenomas and advanced neoplasms was similar between patients with simple steatosis and control subjects. <h3>Conclusions</h3> Non-alcoholic steatohepatitis is associated with a high prevalence of colorectal adenomas and advanced neoplasms. The adenomas are found more commonly in the right sided colon. Colorectal cancer screening is strongly indicated in this high risk group.
Requirement for vasoactive amines for production of delayed-type hypersensitvity skin reactions.
Authors: R K Gershon, P W Askenase, M D Gershon
Journal: The Journal of Experimental Medicine (1975)

The skin sites of the mouse where delayed-type hypersensitivity (DTH) reactions are most easily elicited (foot pads and ears) are particularly rich in 5-hydroxytryptamine (5-HT)-containing mast cells. Since mice are deficient in circulating basophils, which play a role in at least some DTH reactions, we investigated the possibility that the mast cells were playing an important role in the evolution of the skin reactions of DTH in mice. We found that reserpine, a drug which depletes mast cells of 5-HT, abolished the ability of the mouse to make DTH reactions in the skin. The suppressive effect of reserpine could be partially blocked by monoamine oxidase inhibitors which prevent the degradation of 5-HT in the cytosol of the mast cell. Spleen cells of immune, reserpine-treated mice transferred DTH reactions to nonimmune mice normally, indicating that the reserpine treatment did not affect immune T cells. DTH reactions could not be transferred into reserpine-treated mice. We suggest that T cells are continually emigrating from the blood, through postcapillary venule endothelium, by a mechanism which does not depend on vasoactive amines. If they are appropriately immune and meet the homologous antigen in the tissue, they induce mast cells to release vasoactive amines which cause postcapillary venule endothelial cells to separate, allowing the egress from the blood of cells which ordinarily do not recirculate. The secondarily arriving vasoactive amine-dependent cells are responsible for the micro- and macroscopic lesions of DTH reactions. Chemotactic factors may also be involved in bringing cells to the DTH reaction sites but we propose that T-cell regulation of vasoactive amine-containing cells allows the effector cells to pass through the endothelial gates after they are called.
UK recommends PIP breast implants should not be removed
Authors: A. O'Dowd
Journal: BMJ (2011)

The UK’s drug regulatory body has recommended that women who have been implanted with Poly Implant Prosthese (PIP) breast implants should not have them removed, despite concerns raised in France.

The French regulatory authority AFSSAPS (Agence Francaise de Securite Sanitaire des Produits de Sante) is expected to issue a statement on 23 December on the safety of the implants, after reports of the death of a woman who had this type of implant from anaplastic large cell lymphoma.

However, in the UK, the Medicines and Healthcare products Regulatory Agency has played down fears saying that it has been monitoring the safety of the implants and has concluded there is currently …
Effect of fluticasone propionate/salmeterol on exercise endurance in moderate-severe COPD
Authors: Wenlan Yang, Jinming Liu, Beilan Gao, Kebing Cheng
Journal: European Respiratory Journal (2012)

Objective  To investigate the effect of Fluticasone Propionate/Salmeterol on exercise endurance and pulmonary function in patients with moderate-severe COPD.  Methods  53 patients with moderate-severe COPD were randomly divided to two groups. Treatment group inhaled dry powder SFC(salmeterol 50ug, fluticasone Propionate 250ug) twice daily for 24 weeks. Control group got symptomatic treatment for 24 weeks. Predose and postdose pulmonary and cycle cardiopulmonary exercise test evaluations were compared.  Results  There were no difference in predose pulmonary and CPET between two groups. In treatment group, With SFC treatment for 24weeks, FVC, FEV 1 , IC were significient increased; ITGV,RV and TLV were significient decreased( p  2 , peak VO 2 /Kg, peak VCO 2 , peak O 2  pulse, peak VE were significient increased( p  p  2 ,but not with FEV 1 . Predose and postdose pulmonary and CPET were no changes in control group.  Conclusion  Exercise tolerance in patients with moderate-severe COPD were distinguished impaired. After long term SFC treatment, lung hyperinflation at rest and exercise were decreased, exercise endurance were increased when compared with symptomatic treatment. CPET is useful in COPD patients as it allows objective measurement of the exercise tolerance and evaluation of the response to therapeutic intervention.
Serum Aldosterone and the Incidence of Hypertension in Nonhypertensive Persons
Authors: Ramachandran S. Vasan, Jane C. Evans, Martin G. Larson, Peter W.F. Wilson, James B. Meigs, Nader Rifai, Emelia J. Benjamin, Daniel Levy
Journal: New England Journal of Medicine (2004)

Primary hyperaldosteronism is a well-recognized cause of secondary hypertension. It is unknown whether serum aldosterone levels within the physiologic range influence the risk of hypertension.
Effect of E.Coli Phage Lysate Vaccinations on Cd4 + Cd25 + Foxp3+ T-Regulatory Cells and Cytokine Levels in Cancer Bearing Mice
Authors: K. Gambashidze, I. Pantsulaia, M. Iobadze, T. Azaladze, A. Azaladze, K. Kalandarishvili, P. Khorava, E. Jaiani, B. Lasareishvili, M. Tediashvili
Journal: Annals of Oncology (2014)
When All is said and Done
Authors: Baruj Benacerraf
Journal: Annual Review of Immunology (1991)

Dr. Benacerraf describes his experience in training immunologists for a period of over 30 years. He then analyzes the circumstances in which selected discoveries were made in his laboratory and the events and reasoning that led to these findings. The following topics are discussed: The phagocytic activity of the reticulo-endothelial system. The pathogenesis of immune complex diseases. The impact of activated macrophages on tumor rejection. The evidence that T-cell immunity is specific for internal protein determinants generated by antigen processing. The maturation of the antibody response in terms of antibody affinity. The discovery of Ir gene control of specific immuner esponses and the role of MHC molecules as presenters of peptide antigens to T cells. The generation of alloreactivity. Lastly, he addresses the administration of science and, particularly, the problems related to the transfer of technology to industrial partners.
Autoregulation of Coronary Blood Flow: Effect of Interarterial Pressure Gradients
Authors: THOMAS E. DRISCOL, THOMAS W. MOIR, RICHARD W. ECKSTEIN
Journal: Circulation Research (1964)

In the normal heart, transient and adjusted steady state coronary flow rates in response to changes in perfusion pressure are not significantly affected by collateral flow into and from heart muscle surrounding the area perfused by a test artery. An active autoregulatory adjustment tends to counteract flow changes after perfusion pressure is changed. This adjustment is sometimes sufficient to increase vascular resistance above control values. Usually, however, coronary resistance decreases at higher perfusion pressures even though autoregulation is present. The experiments provide no evidence for reflex control of coronary resistance in response to increases in aortic pressure; the initial flow changes can be accounted for by the corresponding increase in perfusion pressure. It is necessary to examine the entire coronary flow pattern after a sudden change in perfusion pressure in order to formulate concepts which include all the important determinants of coronary blood flow.
Enhancing Repair of the Mammalian Heart
Authors: Maria Paola Santini, Lana Tsao, Laurent Monassier, Catherine Theodoropoulos, Janice Carter, Enrique Lara-Pezzi, Esfir Slonimsky, Ekaterina Salimova, Patrice Delafontaine, Yao-Hua Song, Martin Bergmann, Christian Freund, Ken Suzuki, Nadia Rosenthal
Journal: Circulation Research (2007)

The injured mammalian heart is particularly susceptible to tissue deterioration, scarring, and loss of contractile function in response to trauma or sustained disease. We tested the ability of a locally acting insulin-like growth factor-1 isoform (mIGF-1) to recover heart functionality, expressing the transgene in the mouse myocardium to exclude endocrine effects on other tissues. supplemental mIGF-1 expression did not perturb normal cardiac growth and physiology. Restoration of cardiac function in post-infarct mIGF-1 transgenic mice was facilitated by modulation of the inflammatory response and increased antiapoptotic signaling. mIGF-1 ventricular tissue exhibited increased proliferative activity several weeks after injury. The canonical signaling pathway involving Akt, mTOR, and p70S6 kinase was not induced in mIGF-1 hearts, which instead activated alternate PDK1 and SGK1 signaling intermediates. The robust response achieved with the mIGF-1 isoform provides a mechanistic basis for clinically feasible therapeutic strategies for improving the outcome of heart disease.
Absence of CD36 protects against atherosclerosis in ApoE knock-out mice with no additional protection provided by absence of scavenger receptor A I/II
Authors: S. Kuchibhotla, D. Vanegas, D. J. Kennedy, E. Guy, G. Nimako, R. E. Morton, M. Febbraio
Journal: Cardiovascular Research (2007)

AimsThe role of scavenger receptors in atherogenesis is controversial as a result of conflicting reports and a recent hypothesis suggesting that scavenger receptor absence would enhance the pro-inflammatory, pro-atherogenic milieu. This study addresses the effect of combined absence of scavenger receptors CD36 and SRA I/II on atherosclerosis lesion development in the apolipoprotein E knock-out (apoE°) model.
A canine conditionally replicating adenovirus for evaluating oncolytic virotherapy in a syngeneic animal model
Authors: Akseli Hemminki, Anna Kanerva, Eric J Kremer, Gerd J Bauerschmitz, Bruce F Smith, Bin Liu, Minghui Wang, Renee A Desmond, Anne Keriel, Brian Barnett, Henry J Baker, Gene P Siegal, David T Curiel
Journal: Molecular Therapy (2003)

Oncolytic adenoviruses, which selectively replicate in and subsequently kill cancer cells, have emerged as a promising approach for treatment of tumors resistant to other modalities. Although preclinical results have been exciting, single-agent clinical efficacy has been less impressive heretofore. The immunogenicity of adenoviruses, and consequent premature abrogation of replication, may have been a partial reason. Improving the oncolytic potency of agents has been hampered by the inability to study host–vector interactions in immune-competent systems, since human serotype adenoviruses do not productively replicate in animal tissues. Therefore, approaches such as immunomodulation, which could result in sustained replication and subsequently increased oncolysis, have not been studied. Utilizing the osteocalcin promoter for restricting the replication of a canine adenovirus to dog osteosarcoma cells, we generated and tested the first nonhuman oncolytic adenovirus. This virus effectively killed canine osteosarcoma cells in vitro and yielded a therapeutic benefit in vivo. Canine osteosarcoma is the most frequent malignant disease in large dogs, with over 8000 cases in the United States annually, and there is no curative treatment. Therefore, immunomodulation for increased oncolytic potency could be studied with clinical trials in this population. This could eventually translate into human trials.
Glucocorticoid receptor dimerization induces MKP1 to protect against TNF-induced inflammation
Authors: Sofie Vandevyver, Lien Dejager, Tom Van Bogaert, Anna Kleyman, Yusen Liu, Jan Tuckermann, Claude Libert
Journal: Journal of Clinical Investigation (2012)

Glucocorticoids acting through the glucocorticoid receptor (GR) inhibit TNF-induced lethal inflammation. Here, we demonstrate that GR dimerization plays a role in reducing TNF sensitivity. In mutant mice unable to dimerize GR, we found that TNF failed to induce MAPK phosphatase 1 (MKP1). We assessed TNF sensitivity in Mkp1(-/-) mice and found increased inflammatory gene induction in livers, increased circulating cytokines, cell death in intestinal epithelium, severe intestinal inflammation, hypothermia, and death. Mkp1(-/-) mice had increased levels of phosphorylated JNK, which promotes apoptosis, in liver tissue. We further examined JNK-deficient mice for their response to TNF. Although Jnk1(-/-) mice showed no change in sensitivity to TNF, Jnk2(-/-) mice were significantly protected against TNF, identifying JNK2 as an essential player in inflammation induced by TNF. Furthermore, we found that loss of Jnk2 partially rescued the increased sensitivity of Mkp1(-/-) and mutant GR mice to TNF. Our data show that GR dimerization inhibits JNK2 through MKP1 and protects from TNF-induced apoptosis and lethal inflammation.
Alveolar socket healing: what can we learn?
Authors: Mauricio G. Araújo, Cléverson O. Silva, Mônica Misawa, Flavia Sukekava
Journal: Periodontology 2000 (2015)

Abstract Tooth extraction induces a series of complex and integrated local changes within the investing hard and soft tissues. These local alterations arise in order to close the socket wound and to restore tissue homeostasis, and are referred to as ‘“socket healing”. The aims of the present report were twofold: first, to describe the socket‐healing process; and, second, to discuss what can be learned from the temporal sequence of healing events, in order to improve treatment outcomes. The socket‐healing process may be divided into three sequential, and frequently overlapping, phases: inflammatory; proliferative; and modeling/remodeling. Several clinical and experimental studies have demonstrated that the socket‐healing process promotes up to 50% reduction of the original ridge width, greater bone resorption at the buccal aspect than at the lingual/palatal counterpart and a larger amount of alveolar bone reduction in the molar region. In conclusion, tooth extraction, once a simple and straightforward surgical procedure, should be performed in the knowledge that ridge reduction will follow and that further clinical steps should be considered to compensate for this, when considering future options for tooth replacement.
Phase II Study of Lapatinib in Recurrent or Metastatic Epidermal Growth Factor Receptor and/or erbB2 Expressing Adenoid Cystic Carcinoma and Non–Adenoid Cystic Carcinoma Malignant Tumors of the Salivary Glands
Authors: Mark Agulnik, Ezra W.E. Cohen, Roger B. Cohen, Eric X. Chen, Everett E. Vokes, Sebastien J. Hotte, Eric Winquist, Scott Laurie, D. Neil Hayes, Janet E. Dancey, Shirley Brown, Gregory R. Pond, Ian Lorimer, Manijeh Daneshmand, James Ho, Ming-Sound Tsao, Lillian L. Siu
Journal: Journal of Clinical Oncology (2007)

Expression of erbB2 and/or epidermal growth factor receptor (EGFR) is associated with biologic aggressiveness and poor prognosis in malignant salivary gland tumors (MSGTs). This phase II study was conducted to determine the antitumor activity of lapatinib, a dual inhibitor of EGFR and erbB2 tyrosine kinase activity, in MSGTs.Patients with progressive, recurrent, or metastatic adenoid cystic carcinoma (ACC) immunohistochemically expressing at least 1+ EGFR and/or 2+ erbB2 were treated with lapatinib 1,500 mg daily, in a two-stage cohort. Patients with non-ACC MSGTs were treated as a separate single-stage cohort.Of 62 patients screened, 29 of 33 (88%) ACC and 28 of 29 (97%) non-ACC patients expressed EGFR and/or erbB2. Forty patients with progressive disease were enrolled onto the study. Among 19 assessable ACC patients, there were no objective responses, 15 patients (79%) had stable disease (SD), nine patients (47%) had SD > or = 6 months, and four patients (21%) had progressive disease (PD). For 17 assessable non-ACC patients, there were no objective responses, eight patients (47%) had SD, four patients (24%) had SD > or = 6 months, and nine patients (53%) had PD. The most frequent adverse events were grade 1 to 2 diarrhea, fatigue, and rash. Eight paired tumor biopsies for correlative studies were procured; results did not correlate with clinical outcome.Although no responses were observed, lapatinib was well tolerated, with prolonged tumor stabilization of > or = 6 months in 36% (95% CI, 21% to 54%) of assessable patients. The antitumor effects of lapatinib in MGSTs appear mainly cytostatic, hence evaluation of other molecular targeted agents, or combinations with lapatinib, may be considered. Continued efforts should be made to gain better understanding into the biology of this heterogeneous group of malignancies.
Applications of multivariate analysis to the fitness assessment of soccer players [proceedings]
Authors: T. Reilly, V. Thomas
Journal: British Journal of Sports Medicine (1977)

Fitness studies have usually been limited to a few variables, for example, aerobic power by oxygen uptake (Saltin and Astrand, 1967) and anaerobic power (Margaria et al, 1966).More recently, fibre typing from muscle biopsy samples has been employed.(Gollnick et al, 1972).In broader perspective fitness is multifaceted and fitness requirements are sports specific so that uni- variate analysis has limited prognostic utility.We have conducted fitness tests employing inter-disciplinary and multivariate methods of data analysis.
Regulation of Insulin-Like Growth Factor-Binding Protein (IGFBP) Expression by Breast Cancer Cells: Use of IGFBP-1 as as Inhibitor of Insulin-like Growth Factor Action
Authors: W. L. McGuire, J. G. Jackson, J. A. Figueroa, S. Shimasaki, D. R. Powell, D. Yee
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article Regulation of Insulin-Like Growth Factor-Binding Protein (IGFBP) Expression by Breast Cancer Cells: Use of IGFBP-1 as as Inhibitor of Insulin-like Growth Factor Action Get access William L. McGuire, Jr., William L. McGuire, Jr. Department of Medicine, Division of Medical Oncology, University of Texas Health Science CenterSan Antonio † Deceased Search for other works by this author on: Oxford Academic PubMed Google Scholar James G. Jackson, James G. Jackson Department of Medicine, Division of Medical Oncology, University of Texas Health Science CenterSan Antonio Search for other works by this author on: Oxford Academic PubMed Google Scholar Joseé A. Figueroa, Joseé A. Figueroa Department of Medicine, Division of Medical Oncology, University of Texas Health Science CenterSan Antonio Search for other works by this author on: Oxford Academic PubMed Google Scholar Shunichi Shimasaki, Shunichi Shimasaki S. Shimasaki, Department of Molecular Endocrinology. The Whitter Institute for Diabetes and EndocrinologyLa Jolla, Calif Search for other works by this author on: Oxford Academic PubMed Google Scholar David R. Powell, David R. Powell Diabetes Research Center, Baylor College of MedicineHouston, Tex Search for other works by this author on: Oxford Academic PubMed Google Scholar Douglas Yee Douglas Yee * Department of Medicine, Division of Medical Oncology, University of Texas Health Science CenterSan Antonio *Correspondence to : Douglas Yee, M.D., Department of Medicine, Division of Medical Oncology, University of Texas Health Science Center, 7703 Floyd Curl DR., San Antonio, TX 78284–7884. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 17, 2 September 1992, Pages 1336–1341, https://doi.org/10.1093/jnci/84.17.1336 Published: 02 September 1992 Article history Received: 03 March 1992 Revision received: 14 May 1992 Accepted: 27 May 1992 Published: 02 September 1992
Lymphocytoma cutis induced by cobalt
Authors: T. Miyamoto, K. Iwasaki, Y. Mihara, Y. Hagari, M. Mihara
Journal: British Journal of Dermatology (1997)

Journal Article Lymphocytoma cutis induced by cobalt Get access T. Miyamoto, T. Miyamoto Department of Dermatology, Tsuyama Central Hospital, 67 Nikaimachi, 708 Tsuyama, Japan Search for other works by this author on: Oxford Academic Google Scholar K. Iwasaki, K. Iwasaki Department of Dermatology, Tottori University, Faculty of Medicine, Yanago, Japan Search for other works by this author on: Oxford Academic Google Scholar Y. Mihara, Y. Mihara Department of Dermatology, Tottori University, Faculty of Medicine, Yanago, Japan Search for other works by this author on: Oxford Academic Google Scholar Y. Hagari, Y. Hagari Department of Dermatology, Tottori University, Faculty of Medicine, Yanago, Japan Search for other works by this author on: Oxford Academic Google Scholar M. Mihara M. Mihara Department of Dermatology, Tottori University, Faculty of Medicine, Yanago, Japan Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 137, Issue 3, 1 September 1997, Pages 469–471, https://doi.org/10.1111/j.1365-2133.1997.tb03763.x Published: 01 September 1997
SPECIFIC HYPERSENSITIVENESS OR ALLERGY IN RELATION TO CERTAIN ERUPTIONS OF MICROBIC ORIGIN
Authors: H. G. ADAMSON
Journal: British Journal of Dermatology (1916)

Journal Article SPECIFIC HYPERSENSITIVENESS OR ALLERGY IN RELATION TO CERTAIN ERUPTIONS OF MICROBIC ORIGIN Get access H. G. ADAMSON, M.D.Lond H. G. ADAMSON, M.D.Lond Physician‐in‐Charge, Skin‐Department, St. Bartholomew's Hospital Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 28, Issue 1-3, 3 January 1916, Pages 27–31, https://doi.org/10.1111/j.1365-2133.1916.tb16752.x Published: 03 January 1916