Tetany Secondary to the Use of a Proton-Pump Inhibitor
Authors: Vishakalakshmi Subbiah, John A. Tayek
Journal: Annals of Internal Medicine (2002)

Letters6 August 2002Tetany Secondary to the Use of a Proton-Pump InhibitorVishakalakshmi Subbiah, MBBS and John A. Tayek, MS, MDVishakalakshmi Subbiah, MBBSHarbor–UCLA Medical Center; Torrance, CA 90509 and John A. Tayek, MS, MDHarbor–UCLA Medical Center; Torrance, CA 90509Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-137-3-200208060-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Calcium is well absorbed in the presence of acid, but absorption is decreased by 80% in patients with achlorhydria (1). Six years after near total thyroidectomy, a 46-year-old woman presented to her primary care physician with symptoms of heartburn. Gastroesophageal reflux disease was diagnosed, and the patient was prescribed ranitidine, 150 mg orally twice per day. After 3 months of persistent gastroesophageal reflux disease, her symptoms were relieved with a proton-pump inhibitor (lansoprazole, 30 mg).Approximately 2 weeks after treatment with the proton-pump inhibitor, the patient reported numbness, chest pressure, and muscle cramping in the hands and ...References1. Recker RR. Calcium absorption and achlorhydria. N Engl J Med. 1985;313:70-3. [PMID: 4000241] CrossrefMedlineGoogle Scholar2. Gagnemo-Persson R, Samuelsson A, Hâkanson R, Persson P. Chicken parathyroid hormone gene expression in response to gastrin, omeprazole, ergocalciferol, and restricted food intake. Calcif Tissue Int. 1997;61:210-5. [PMID: 9262512] CrossrefMedlineGoogle Scholar3. Tougaard L, Rickers H, Rödbro P, Thaysen EH, Christensen MS, Lund B, et al . Bone composition and vitamin D after Pólya gastrectomy. Acta Med Scand. 1977;202:47-50. [PMID: 899882] CrossrefMedlineGoogle Scholar4. Mizunashi K, Furukawa Y, Katano K, Abe K. Effect of omeprazole, an inhibitor of H +,K(+)-ATPase, on bone resorption in humans. Calcif Tissue Int. 1993;53:21-5. [PMID: 8102318] CrossrefMedlineGoogle Scholar5. Werga-Kjellman P, Zedenius J, Tallstedt L, Träisk F, Lundell G, Wallin G. Surgical treatment of hyperthyroidism: a ten-year experience. Thyroid. 2001;11:187-92. [PMID: 11288990] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Harbor–UCLA Medical Center; Torrance, CA 90509Grant Support: By the U.S. National Institutes of Health Clinical Investigator Award KO8DK02083 and MO1-RR-00425. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoRecurrent Hypomagnesemia With Proton-Pump Inhibitor Rechallenge Maria Quasdorff , Jessica Mertens , Johanna Dinter , and Hans-Michael Steffen Metrics Cited byDrug-induced hypocalcemiaAcute Hypocalcemia from Proton Pump Inhibitor UseRetrospective analysis of the effect of acid-suppressant therapy on clinicopathologic parameters of cats with chronic kidney diseaseManagement of Hypoparathyroidism: Summary Statement and GuidelinesManagement of Hypoparathyroidism: Present and FutureGastric Acid-Dependent Diseases: A Twentieth-Century Revolution78-jährige Patientin mit Unwohlsein, Schwindel, Apraxie und Krampfanfall unter ProtonenpumpeninhibitortherapieSystematic review: hypomagnesaemia induced by proton pump inhibitionDisorders of Calcium, Magnesium, and Phosphate BalanceRecurrent Hypomagnesemia With Proton-Pump Inhibitor RechallengeMaria Quasdorff, MD PhD, Jessica Mertens, MD, Johanna Dinter, MD, and Hans-Michael Steffen, MDProton Pump Inhibitor-Induced Hypocalcemic Seizure in A Patient with HypoparathyroidismMuscle Stiffness in Critical Illness Is Not a Form of Rigor MortisSevere Hypomagnesemia During Long-term Treatment With a Proton Pump InhibitorProton Pump Inhibitor Suppression of Calcium Absorption Presenting as Respiratory Distress in a Patient with Bilateral Laryngeal Paralysis and HypocalcemiaNutrition in the Age of PolypharmacyA patient with a transient photomyogenic responseA review of drug-induced hypocalcemiaOverutilization of Proton Pump Inhibitors: A Review of Cost-Effectiveness and Risk in PPIOverutilization of Proton Pump InhibitorsSevere hypomagnesaemia in long-term users of proton-pump inhibitorsProton-Pump Inhibitors and Hypomagnesemic HypoparathyroidismInfluence of Medication on Nutritional StatusHungry bone syndrome: A case report and review of the literatureA Perspective on Drug-Nutrient InteractionsAlopecia Associated with HMG-CoA Reductase Inhibitor; "Delayed, Recurrent" SIADH and SSRIs; Serious Adverse Effects with Acetazolamide; Tetany Associated with Proton Pump InhibitorLansoprazole 6 August 2002Volume 137, Issue 3Page: 219KeywordsAttentionBoneCalciumCarbonatesGastroesophageal reflux diseaseHypocalcemiaMusclesParathyroidParathyroid hormoneThyroidectomy ePublished: 6 August 2002 Issue Published: 6 August 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...