An Evaluation of Isocitric Dehydrogenase in Liver Disease
Authors: NORMAN N. COHEN
Journal: Annals of Internal Medicine (1961)

Article1 October 1961An Evaluation of Isocitric Dehydrogenase in Liver DiseaseNORMAN N. COHEN, M.D., H. PHELPS POTTER JR., M.D., GEORGE N. BOWERS JR., M.D.NORMAN N. COHEN, M.D.Search for more papers by this author, H. PHELPS POTTER JR., M.D.Search for more papers by this author, GEORGE N. BOWERS JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-55-4-604 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptLaboratory evaluation of hepatocellular damage has been aided in recent years by the development of new methods for measuring serum activities of enzymes released from injured liver cells. One of these enzymes is isocitric dehydrogenase; in the Kreb's cycle, this enzyme catalyzes the dehydrogenation and decarboxylation of isocitrate to alpha-ketoglutarate (1). The method for the determination of serum isocitric dehydrogenase offers some technical advantages when it is compared with the spectrophotometric methods for the serum transaminases [glutamic-oxaloacetic and glutamic-pyruvic transaminases] (2). Furthermore, although the liver and the myocardium show comparable activities of isocitric dehydrogenase, increased activity of this enzyme in...References1. ENGLARDCOLOWICK SSP: On the mechanism of the aconitase and isocitric dehydrogenase reactions. J. Biol. Chem. 226: 1047, 1957. CrossrefMedlineGoogle Scholar2. BOWERS GN: Measurement of isocitric dehydrogenase activity in body fluids. Clin. Chem. 5: 509, 1959. CrossrefMedlineGoogle Scholar3. STERKELSPENCERWOLFSONWILLIAMS-ASHMAN RLJASKHG: Serum isocitric dehydrogenase activity with particular reference to liver disease. J. Lab. Clin. Med. 52: 176, 1958. MedlineGoogle Scholar4. OKUMURASPELLBERG MMA: Serum isocitric dehydrogenase activity in the differential diagnosis of liver disease. Gastroenterology 39: 305, 1960. CrossrefMedlineGoogle Scholar5. KARMENWROBLEWSKILADUE AFJS: Transaminase activity in human blood. J. Clin. Invest. 34: 126, 1955. CrossrefMedlineGoogle Scholar6. WROBLEWSKILADUE FJS: Serum glutamic pyruvic transaminase in cardiac and hepatic disease. Proc. Soc. Exp. Biol. Med. 91: 569, 1956. CrossrefMedlineGoogle Scholar7. POPPERSCHAFFNER HF: Liver Structure and Function, McGraw-Hill Book Co., Inc., New York, 1957, pp. 520-531. Google Scholar8. BODANSKYSCHWARTZKRUGMANGILESJACOBS OMKSJPHM: Comparison of activities of isocitric dehydrogenase and glutamic-oxaloacetic transaminase in serum in infectious hepatitis. Pediatrics 25: 807, 1960. MedlineGoogle Scholar9. COHENHOLLENDONNERMYERSON NNWJRJ: Experiences with percutaneous needle biopsy of the liver. Delaware Med. J. 30: 395, 1958. Google Scholar10. STRANDJORDTHOMASWHITE PEKELP: Studies on isocitric and lactic dehydrogenases in experimental myocardial infarction. J. Clin. Invest. 38: 2111, 1959. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: NORMAN N. COHEN, M.D.; H. PHELPS POTTERJR., M.D.; GEORGE N. BOWERSJR., M.D.Affiliations: Philadelphia, PennsylvaniaReceived for publication March 15, 1961.From the Gastrointestinal Section (Kinsey-Thomas Foundation) and the William Pepper Laboratory of Clinical Medicine of the Hospital and the School of Medicine of the University of Pennsylvania, 3400 Spruce Street, Philadelphia 4, Pa.Aided by Grant H-4220, U. S. Public Health Service, National Institutes of Health.Requests for reprints should be addressed to Norman N. Cohen, M.D., Gastrointestinal Section, Kinsey-Thomas Foundation, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia 4, Pa. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byGlycylprolyl-p-nitroanilidase in hepatobiliary diseaseClinical Utilization of Alkaline Phosphatase MeasurementsLiver damage in heatstrokeSerum adenosine deaminase activity in hepatic diseaseSerum isocitrate dehydrogenase in obstructive jaundiceSerum enzymes in disease.XIV. Abnormality of levels of transaminases and glycolytic and oxidative enzymes and of liver functions as related to the extent of metastatic carcinoma of the liverSorbitol Dehydrogenase and Hepatocellular Injury: An Experimental and Clinical StudyLiver Disease 1 October 1961Volume 55, Issue 4Page: 604-609KeywordsAminotransferasesDehydrogenasesEnzymesHospital medicineLiverLiver diseasesMedical servicesMyocardiumNecrosisResearch laboratories ePublished: 1 December 2008 Issue Published: 1 October 1961 PDF downloadLoading ...