tbuckley/cabot-search huggingface dataset:
Intramuscular methotrexate in inflammatory rheumatic disease
Authors: G BURBAGE
Journal: Annals of the Rheumatic Diseases (2001)

We read with great interest the recent letter entitled “Is parenteral methotrexate worth trying?” by Osman and Mulherin.1 There has been an increased use of intramuscular methotrexate (IM-MTX) in our department in the past two years, leading to an increased workload in the nurse-led monitoring clinics and in the cost. This has prompted us to review the clinical utility of switching patients to IM-MTX. In addition, we have recorded patients' experiences, focusing chiefly on patient satisfaction, with this treatment.

Medical case notes of 31 patients who had started treatment with IM-MTX, identified from our database, were examined. The clinical diagnosis, previous drug treatment, reason for changing to IM-MTX, efficacy, and side effects were noted. In addition, the patients were asked to complete a questionnaire, looking at patient satisfaction and preferred venue for injections (monitoring clinic or local doctor's …
Ionizing radiation sensitizes erythroleukemic cells but not normal erythroblasts to tumor necrosis factor–related apoptosis-inducing ligand (TRAIL)–mediated cytotoxicity by selective up-regulation of TRAIL-R1
Authors: Roberta Di Pietro, Paola Secchiero, Rosalba Rana, Davide Gibellini, Giuseppe Visani, Kristi Bemis, Loris Zamai, Sebastiano Miscia, Giorgio Zauli
Journal: Blood (2001)
A recurrent 15q13.3 microdeletion syndrome associated with mental retardation and seizures
Authors: Andrew J Sharp, Heather C Mefford, Kelly Li, Carl Baker, Cindy Skinner, Roger E Stevenson, Richard J Schroer, Francesca Novara, Manuela De Gregori, Roberto Ciccone, Adam Broomer, Iris Casuga, Yu Wang, Chunlin Xiao, Catalin Barbacioru, Giorgio Gimelli, Bernardo Dalla Bernardina, Claudia Torniero, Roberto Giorda, Regina Regan, Victoria Murday, Sahar Mansour, Marco Fichera, Lucia Castiglia, Pinella Failla, Mario Ventura, Zhaoshi Jiang, Gregory M Cooper, Samantha J L Knight, Corrado Romano, Orsetta Zuffardi, Caifu Chen, Charles E Schwartz, Evan E Eichler
Journal: Nature Genetics (2008)
Longitudinal Study of Age-Related Cataract Using Dynamic Light Scattering
Authors: Manuel B. Datiles, Rafat R. Ansari, Junko Yoshida, Holly Brown, Andrea I. Zambrano, Jing Tian, Susan Vitale, J. Samuel Zigler, Frederick L. Ferris, Sheila K. West, Walter J. Stark
Journal: Ophthalmology (2015)
A Multicenter, Open-Label Phase II Clinical Trial of Combined MEK plus EGFR Inhibition for Chemotherapy-Refractory Advanced Pancreatic Adenocarcinoma
Authors: Andrew H. Ko, Tanios Bekaii-Saab, Jessica Van Ziffle, Olga M. Mirzoeva, Nancy M. Joseph, AmirAli Talasaz, Peter Kuhn, Margaret A. Tempero, Eric A. Collisson, R. Kate Kelley, Alan P. Venook, Elizabeth Dito, Anna Ong, Sharvina Ziyeh, Ryan Courtin, Regina Linetskaya, Sanaa Tahiri, W. Michael Korn
Journal: Clinical Cancer Research (2015)

Abstract Purpose: On the basis of preclinical evidence of synergistic activity between MEK and EGFR inhibitors in pancreatic ductal adenocarcinoma (PDAC), we evaluated the safety and efficacy of selumetinib, a MEK1/2 inhibitor, plus erlotinib in patients with previously treated advanced PDAC. Experimental Design: In this single-arm phase II trial, eligible patients received the combination of erlotinib 100 mg plus selumetinib 100 mg daily in 3-week cycles. Study assessments included measurement of clinical outcomes, with a primary endpoint of overall survival, and exploration of potential molecular predictors of treatment benefit. Results: Forty-six patients were enrolled and received a median of two cycles (range, 1–7). Although no objective responses were observed, 19 patients (41%) showed evidence of stable disease for ≥6 weeks, and 13 of 34 patients (38%) had a CA19-9 decline ≥50%. Median progression-free survival was 1.9 months [95% confidence interval (CI), 1.4–3.3 months], with a median overall survival of 7.3 months (95% CI, 5.2–8.0 months). Common adverse events included rash, diarrhea, and nausea/vomiting. Patients with tumors exhibiting an epithelial phenotype (demonstrated by a high level of E-cadherin expression) were more likely to be sensitive to study treatment. Tumor-derived DNA was detectable in plasma from the majority of patients using next-generation digital DNA sequencing, and its relative abundance correlated with tumor burden. Conclusions: A therapeutic strategy of dual targeted inhibition of the MEK and EGFR pathways shows modest antitumor activity in pancreatic cancer. Specific molecular subtypes may derive greatest benefit from this combination. Further exploration, both with more potent MEK inhibitors and in molecularly enriched patient subsets, is warranted. Clin Cancer Res; 22(1); 61–68. ©2015 AACR.
Intensive chemotherapy (high-dose CHOP/ESHAP regimen) followed by autologous stem-cell transplantation in previously untreated patients with peripheral T-cell lymphoma
Authors: S. Mercadal, J. Briones, B. Xicoy, C. Pedro, L. Escoda, C. Estany, M. Camós, L. Colomo, Í. Espinosa, S. Martínez, J.M. Ribera, R. Martino, G. Gutiérrez-García, E. Montserrat, A. López-Guillermo
Journal: Annals of Oncology (2008)
Change of left atrial systolic pressure waveform in relation to left ventricular end-diastolic pressure.
Authors: Y Matsuda, Y Toma, M Matsuzaki, K Moritani, A Satoh, K Shiomi, N Ohtani, M Kohno, T Fujii, K Katayama
Journal: Circulation (1990)

The relation between the left atrial systolic pressure waveform and left ventricular end-diastolic pressure was observed in 17 patients who underwent diagnostic cardiac catheterization. Left atrial pressure and left ventricular pressure were simultaneously recorded from a multisensor catheter before and during angiotensin infusion. Left ventricular systolic pressure and left ventricular end-diastolic pressure were 133 +/- 17 and 12.3 +/- 3.2 mm Hg, respectively, before angiotensin infusion and increased to 168 +/- 18 (p less than 0.01) and 19.4 +/- 4.5 mm Hg (p less than 0.01), respectively, during infusion. The left atrial systolic pressure curve consisted of two positive waves--a first wave (A) and a second wave (A'). The A and A' wave pressures were 11.6 +/- 2.3 and 10.2 +/- 3.9 mm Hg, respectively, before angiotensin infusion and 16.5 +/- 2.9 (p less than 0.01) and 18.1 +/- 4.7 mm Hg (p less than 0.01), respectively, during infusion. The ratio of A'/A of left atrial systolic pressure was 0.81 +/- 0.27 before angiotensin infusion and 1.08 +/- 0.14 (p less than 0.01) during infusion. The ratio of A' to A of left atrial systolic pressure was linearly related to left ventricular end-diastolic pressure before and during (p less than 0.01) angiotensin infusion. The amplitude of the A wave exceeded that of the A' wave at normal left ventricular end-diastolic pressures. However, as the left ventricular end-diastolic pressure increased either at rest or during angiotensin infusion, the amplitude of the A' wave increased and often exceeded that of the A wave. These results suggest that the second (A') wave might be attributed to the increased reflection associated with increased left ventricular end-diastolic pressure.
Impact of low-intensity isocapnic hyperpnoea on blood lactate disappearance after exhaustive arm exercise
Authors: Claudio Perret, Gabi Mueller
Journal: British Journal of Sports Medicine (2007)

To investigate the impact of low-intensity isocapnic hyperpnoea (IH) on blood lactate disappearance after exhaustive arm exercise in comparison with passive and active recovery using the previously loaded muscle group.Randomised, crossover trial.Institute for Sports Medicine.18 healthy non-smoking and physically active male subjects.Subjects performed three arm cranking tests to volitional exhaustion on 3 different days at least 48 h apart. Arm exercise was randomly followed by 30 min of passive recovery (PR), active arm cranking (AC) at 30% of peak power output or ventilatory recovery (VR) by means of IH at 30% of 12 s maximal voluntary ventilation. Blood lactate concentrations were measured every 2 min during recovery.Blood lactate disappearance during the three different recovery strategies.No significant differences in blood lactate concentrations were found between interventions PR, AC and VR during the whole measurement period. Mean (SD) peak lactate concentrations were 11.09 (1.98) mmol/l for PR, 11.13 (1.44) mmol/l for AC and 11.25 (1.93) mmol/l for VR. At the end of the recovery period measured lactate concentrations were 4.35 (1.56) mmol/l for PR, 3.77 (1.60) mmol/l for AC and 4.09 (1.35) mmol/l for VR. Moreover, all other variables measured were not significantly different, with the exception of higher average recovery heart rates during AC (116 (9) bpm) and VR (111 (17) bpm) compared with PR (93 (11) bpm).Low-intensity IH seems not to enhance blood lactate disappearance after exhaustive arm exercise compared with passive or active recovery using the previously loaded muscle group. The magnitude of the involved muscle mass appears critical to effective active recovery.
Human Epidermal Growth Factor Receptor 2 Testing Recommendation
Authors: Adekunle Raji
Journal: Journal of Clinical Oncology (2007)

We read with great interest the joint recommendations from the American Society of Clinical Oncology and the College of American Pathologists (ASCO/CAP) concerning human epidermal growth factor receptor 2 (HER-2) testing in breast cancer. 1 The new recommendations are highly appreciated, and the validation, standardization, and accreditation initiatives are very important for increasing accuracy in HER-2 testing.The joint ASCO/CAP guideline is based on a comprehensive review of published data on HER-2 testing, except for the recommendation for changing the cutoff of stained cells from 10% to 30%.Most published data are based on results obtained using a US Food and Drug Administration (FDA) -approved test that defines a positive 3ϩ staining as being uniform, intensive membrane staining of more than 10% of invasive tumor cells.The new guideline recommends a different cutoff of 30% for 3ϩ.It is not clear whether there are data that support this new cutoff, and we recommend the publication of data from clinical trials to do so.As a point of correction, we wish to bring to your attention that Dako (Glostrup, Denmark) has a US FDA-approved assay, the HER2 FISH (fluorescence in situ hybridization) pharmDx Kit (Dako Denmark A/S).This kit is indicated as an aid in the assessment of patients for whom Herceptin treatment is being considered. 2 The cutoff stated in the package inserts of the approved tests will still be the legally valid cutoff, and it will be impossible to change it without presenting the US FDA with valid data that correlate to clin-ical outcome.We are concerned that the divergence between the recommendations in the package inserts of the approved HER-2 tests and the ASCO/CAP guideline concerning cutoff will generate confusion rather than clarification.
Peptide hormone binding to G‐protein‐coupled receptors: Structural characterization via NMR techniques
Authors: Dale F. Mierke, Craig Giragossian
Journal: Medicinal Research Reviews (2001)

Abstract G‐protein‐coupled receptors (GPCRs) allow cells to respond to calcium, hormones, and neurotransmitters. Not surprisingly, they currently make up the largest family of validated drug targets. Rational drug design for molecular regulators targeting GPCRs has been limited to theoretical‐based computational approaches. X‐ray crystallography of intact GPCRs has provided the topological orientation of the seven transmembrane helices, but limited structural information of the extracellular and intracellular loops and protein termini. In this review we detail an NMR‐based approach which provides the high‐resolution structural features on the extracellular domains of GPCRs and the ligand/receptor complexes formed upon titration of the peptide hormone. The results provide important contact points and a high‐resolution description of the ligand/receptor interactions, which may be useful for the rational design of therapeutic agents targeting GPCRs. Recent results from our investigation of the cholecystokinin peptide hormone system are used to highlight this approach. © 2001 John Wiley &amp; Sons, Inc. Med Res Rev, 21, No. 5, 450–471, 2001
Sonography as a replacement for sialography for the diagnosis of salivary glands affected by Sjogren's syndrome
Authors: K Yonetsu
Journal: Annals of the Rheumatic Diseases (2002)

Sonography as a replacement for sialography for the diagnosis of salivary glands affected by Sjögren's syndromeRecently, it has been suggested that sonographic evaluation of the salivary glands is useful
Meta-Analysis of Psychosocial Interventions to Reduce Pain in Patients With Cancer
Authors: Sherri Sheinfeld Gorin, Paul Krebs, Hoda Badr, Elizabeth Amy Janke, Heather S.L. Jim, Bonnie Spring, David C. Mohr, Mark A. Berendsen, Paul B. Jacobsen
Journal: Journal of Clinical Oncology (2012)

Pain is one of the most common, burdensome, and feared symptoms experienced by patients with cancer. American Pain Society standards for pain management in cancer recommend both pharmacologic and psychosocial approaches. To obtain a current, stable, and comprehensive estimate of the effect of psychosocial interventions on pain-an important clinical topic-we conducted a meta-analysis of randomized controlled studies among adult patients with cancer published between 1966 and 2010.
The Perirhinal Cortex
Authors: Wendy A. Suzuki, Yuji Naya
Journal: Annual Review of Neuroscience (2014)

Anatomically, the perirhinal cortex sits at the boundary between the medial temporal lobe and the ventral visual pathway. It has prominent interconnections not only with both these systems, but also with a wide range of unimodal and polymodal association areas. Consistent with these diverse projections, neurophysiological studies reveal a multidimensional set of mnemonic signals that include stimulus familiarity, within- and between-domain associations, associative recall, and delay-based persistence. This wide range of perirhinal memory signals not only includes signals that are largely unique to the perirhinal cortex (i.e., object familiarity), consistent with dual-process theories, but also includes a range of signals (i.e., associative flexibility and recall) that are strongly associated with the hippocampus, consistent with single-process theories. These neurophysiological findings have important implications for bridging the gap between single-process and dual-process models of medial temporal lobe function.
F-MARC: promoting the prevention and management of sudden cardiac arrest in football
Authors: Efraim Benjamin Kramer, J Dvorak, C Schmied, T Meyer
Journal: British Journal of Sports Medicine (2015)

Sudden cardiac death is the most common cause of unnatural death in football. To prevent and urgently manage sudden cardiac arrest on the football field-of-play, F-MARC (FIFA Medical and Research Centre) has been fully committed to a programme of research, education, standardisation and practical implementation. This strategy has detected football players at medical risk during mandatory precompetition medical assessments. Additionally, FIFA has (1) sponsored internationally accepted guidelines for the interpretation of an athlete's ECG, (2) developed field-of-play-specific protocols for the recognition, response, resuscitation and removal of a football player having sudden cardiac arrest and (3) introduced and distributed the FIFA medical emergency bag which has already resulted in the successful resuscitation of a football player who had a sudden cardiac arrest on the field-of-play. Recently FIFA, in association with the Institute of Sports and Preventive Medicine in Saarbrücken, Germany, established a worldwide Sudden Death Registry with a view to documenting fatal events on the football field-of-play. These activities by F-MARC are testimony to FIFA's continued commitment to minimising sudden cardiac arrest while playing football.
Association of occupational physical demands and psychosocial working environment with disabling shoulder pain
Authors: D P Pope, A J Silman, N M Cherry, C Pritchard, G J Macfarlane
Journal: Annals of the Rheumatic Diseases (2001)

To estimate the individual and combined associations of physical and psychosocial working environment with disabling shoulder pain and to identify groups at "high risk" for shoulder pain.A cross sectional survey was conducted at five manual occupational settings in south Manchester, United Kingdom (n=775, 83%).Both the duration of occupational physical demands (working postures, manual handling activities, and repetitive arm movements) and psychosocial working environment (psychological demands and lack of opportunity to learn new skills) were found to be significantly associated with shoulder pain. Three occupational factors identified a high risk group for shoulder pain: duration of lifting with one hand (prevalence rate ratio (PRR) (highest third) 2.0, 95% confidence interval (CI) 1.4 to 2.8), duration of working above shoulder level (PRR (highest third) 2.2, 95% CI 1.5 to 3.3), and whether employees found their work stressful (PRR (highest third) 1.4, 95% CI 1.0 to 2.1). In addition, a measure of psychological distress (General Health Questionnaire (GHQ) score) was found to identify a group at high risk for shoulder pain (PRR (highest third) 1.9, 95% CI 1.3 to 2.9). In employees exposed to three or more of these factors, 79% (23/29) reported shoulder pain compared with only 16% (56/353) of those not exposed to any.This study has identified a variety of occupational physical demands and psychosocial factors associated with shoulder pain. It has also identified groups of employees at a "high risk" for shoulder pain by their exposure to both physical and psychosocial factors.
Activity of trabectedin in germline BRCA1/2-mutated metastatic breast cancer: results of an international first-in-class phase II study
Authors: S. Delaloge, R. Wolp-Diniz, T. Byrski, J.L. Blum, A. Gonçalves, M. Campone, P. Lardelli, C. Kahatt, A. Nieto, M. Cullell-Young, J. Lubinski
Journal: Annals of Oncology (2014)
Time of insemination culture and outcomes of in vitro fertilization: a systematic review and meta-analysis
Authors: X.D. Zhang, J.X. Liu, W.W. Liu, Y. Gao, W. Han, S. Xiong, L.H. Wu, G.N. Huang
Journal: Human Reproduction Update (2013)

BACKGROUNDConflicting results have been reported regarding the technique of brief insemination used in IVF. The aim of this meta-analysis was to determine if better clinical outcomes of IVF are associated with a brief co-incubation of gametes than with a standard overnight co-incubation.
Measurement of airway resistance using the interrupter technique in preschool children in the ambulatory setting
Authors: P.D. Bridge, S. Ranganathan, S.A. McKenzie
Journal: European Respiratory Journal (1999)

This study describes the feasibility, repeatability, and interrater reliability of the measurement of airway resistance by the interrupter technique (Rint) in children 2-5 yrs of age, and examines whether reversibility to bronchodilator can be demonstrated in wheezy children. The mean of six Rint values was taken as a measurement. If subjects could complete one measurement and then a second 15 min after bronchodilator, baseline testing and reversibility testing were considered feasible. To measure repeatability, two measurements 30 s apart and measurements before and 15 min after placebo bronchodilator were compared. Measurements by two testers were compared for interrater reliability. Change in Rint in wheezy children was measured after bronchodilator. Fifty-six per cent of 2-3-yr-olds (n=79), 81% of 3-4-yr-olds (n=104) and 95% of 4-5-yr-olds (n=88) completed baseline testing, and 53%, 71% and 91% completed reversibility testing. Baseline measurements were 0.47-2.56 kPa x L(-1) x s. Repeatabilities (2 SD of the mean differences between measurements) at 30 s in the three age bands were 0.21, 0.17 and 0.15 kPa x L(-1) x s and 0.19 kPa x L(-1) x s after placebo. Using 0.21 kPa x L(-1) x s as the threshold for reversibility, reversibility was demonstrated in most wheezy children. Interrater reliability was 0.15 kPa x L(-1) x s. Preschool children can undertake measurements of airway resistance by the interrupter technique in ambulatory settings and reversibility to bronchodilator in wheezy children can be demonstrated. This technique promises to be a useful clinical and research tool.
Plasminogen Activator Inhibitor Type 1 and Tissue Inhibitor of Metalloproteinases-2 Increase After Arterial Injury in Rats
Authors: David Hasenstab, Reza Forough, Alexander W. Clowes
Journal: Circulation Research (1997)

Abstract Vascular injury induced by angioplasty causes smooth muscle cells to migrate, proliferate, and form a neointima. The neointima is further enlarged by the accumulation of matrix molecules synthesized by smooth muscle cells. Smooth muscle cell migration and matrix accumulation are associated with an increase in the expression of matrix-degrading enzymes and might be regulated by the balance of protease and anti-protease activity. We have studied the inhibitors of two major classes of matrix-degrading enzymes, the plasminogen activators and the matrix metalloproteinases (MMPs) to understand better the regulation of proteolytic activity following balloon catheter injury in the rat carotid artery. At various times after injury, protease inhibitor expression was analyzed by Northern blotting, reverse zymography, immunohistochemistry, and Western blotting. During the first month after injury, we found that the expression of two proteinase inhibitors (plasminogen activator inhibitor type 1 [PAI-1] and tissue inhibitor of metalloproteinases-2 [TIMP-2]) was modulated. PAI-1 mRNA expression reached a maximum 6 hours after injury before tapering off to baseline levels by 3 days. PAI-1 activity, as measured by reverse zymography, followed the same temporal profile. PAI-1, localized by immunohistochemistry, was expressed at low levels in the media of control arteries and was increased after injury primarily in the medial smooth muscle cells. TIMP-2 mRNA levels began to increase 24 hours after injury and reached a maximum at day 7. TIMP-2 activity, measured by reverse zymography, peaked at day 3 after injury. TIMP-2 protein was increased in the intima compared with the media and adventitia at day 7 after injury. The increase of PAI-1 and TIMP-2 after injury supports the hypothesis that changes in the proteolytic balance play an important role in smooth muscle cell migration after arterial injury.
ALLOTYPE SUPPRESSION IN THE RABBIT
Authors: Michael R. Harrison, Rose G. Mage
Journal: The Journal of Experimental Medicine (1973)

The ability to distinguish immunoglobulin (Ig) of paternal allotype both on lymphocyte membranes and in the serum of neonatal b4b5 heterozygous rabbits has allowed us to study the postnatal ontogeny of cells bearing endogenously synthesized Ig that could not have been derived from the mother. In normal b4b5 rabbits, such endogenously synthesized Ig of paternal allotype is present on the membranes of bone marrow-derived (B) lymphocytes from birth, but does not appear as detectable circulating Ig until ∼2 wk of age. In the neonate, cells bearing the paternal allotype are potential targets for the induction of chronic allotype suppression. Within 24 h of exposure to anti-allotype antisera in vivo, Ig of the suppressed paternal allotype is no longer detectable on the surface of neonatal lymphoid cells. Further, this lymphocyte membrane Ig is eliminated and not simply masked by the suppressing antibodies. Finally, cells bearing the suppressed allotype are deleted from all lymphoid organs for the duration of total allotype suppression, and reappear first in bone marrow and peripheral blood at the time of spontaneous escape from suppression.