Postmenopausal Hormones and Glycemic Effects
Authors: John V.L. Sheffield, Eric B. Larson
Journal: Annals of Internal Medicine (2003)

Letters16 December 2003Postmenopausal Hormones and Glycemic EffectsJohn V.L. Sheffield, MD and Eric B. Larson, MD, MPHJohn V.L. Sheffield, MDFrom University of Washington, Harborview Medical Center, Seattle, WA 98104, and Center for Health Studies, Group Health Cooperative; Seattle, WA 98101.Search for more papers by this author and Eric B. Larson, MD, MPHFrom University of Washington, Harborview Medical Center, Seattle, WA 98104, and Center for Health Studies, Group Health Cooperative; Seattle, WA 98101.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-139-12-200312160-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We read with interest Kanaya and colleagues' report that combination hormone replacement therapy (HRT) reduced the incidence of type 2 diabetes mellitus by 35% (6.2% vs. 9.5% [P= 0.006]; number needed to treat for benefit [NNTB] for 4 years= 30) among postmenopausal women with coronary disease (1). We wonder whether the authors can comment on the possible contribution of exercise to the observed effect. Kanaya and colleagues analyzed several potential mediators of treatment effect on diabetes incidence, including waist circumference, body mass index (BMI), change in weight, smoking, markers of the metabolic syndrome, and certain cardiac medications, ...References1. Kanaya AM, Herrington D, Vittinghoff E, Lin F, Grady D, Bittner V, . Glycemic effects of postmenopausal hormone therapy: the Heart and Estrogen/progestin Replacement Study. A randomized, double-blind, placebo-controlled trial. Ann Intern Med. 2003;138:1-9. [PMID: 12513038] LinkGoogle Scholar2. Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA, . Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med. 2002;346:393-403. [PMID: 11832527] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: John V.L. Sheffield, MD; Eric B. Larson, MD, MPHAffiliations: From University of Washington, Harborview Medical Center, Seattle, WA 98104, and Center for Health Studies, Group Health Cooperative; Seattle, WA 98101. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoGlycemic Effects of Postmenopausal Hormone Therapy: The Heart and Estrogen/progestin Replacement Study: A Randomized, Double-Blind, Placebo-Controlled Trial Alka M. Kanaya , David Herrington , Eric Vittinghoff , Feng Lin , Deborah Grady , Vera Bittner , Jane A. Cauley , and Elizabeth Barrett-Connor Postmenopausal Hormones and Glycemic Effects John P. Girod and Daniel J. Brotman Postmenopausal Hormones and Glycemic Effects Aidan McElduff Postmenopausal Hormones and Glycemic Effects Alka M. Kanaya , David Herrington , and Elizabeth Barrett-Connor Metrics 16 December 2003Volume 139, Issue 12 Page: 1043 Keywords Absolute risk reduction Body mass index Body weight Diabetes prevention Estrogen replacement therapy Estrogens Exercise Hormone replacement therapy Metabolic syndrome Type 2 diabetes ePublished: 16 December 2003 Issue Published: 16 December 2003 Copyright & PermissionsCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...