Anti-p24 Antibody Reactivity in the Acquired Immunodeficiency Syndrome (AIDS)-Related Complex Treated with Isoprinosine
Authors: Kwong-Yok Tsang
Journal: Annals of Internal Medicine (1988)

Letters and Corrections1 October 1988Anti-p24 Antibody Reactivity in the Acquired Immunodeficiency Syndrome (AIDS)-Related Complex Treated with IsoprinosineKwong-Yok Tsang, PhD, Elizabeth A. Johnson, PhD, Mariano F. La Via, MDKwong-Yok Tsang, PhDSearch for more papers by this author, Elizabeth A. Johnson, PhDSearch for more papers by this author, Mariano F. La Via, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-7-595_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: Isoprinosine is a synthetic immunopotentiating agent that can enhance interleukin-2 production in vitro, interleukin-2 receptor expression, natural killer cell activity, mitogen-induced lymphocyte proliferation (1), and macrophage activation (2). It also can produce an anti-cytomegalovirus effect in healthy homosexual men and patients with the acquired immunodeficiency syndrome (AIDS)-related complex, as well as increased total T cells and CD4+ cells and normalization of the CD4+: CD8+ ratio in patients with the AIDS-related complex (3).A double-blind, placebo-controlled study of isoprinosine was conducted in 16 patients with AIDS-related complex. Patients receiving the drug received 3 g of isoprinosine daily (two...References1. TsangFudenbergGalbraith KHG. Partial restoration of impaired interleukin-2 production and Tac antigen (putative interleukin-2 receptor) expression in patients with acquired immune deficiency syndrome by isoprinosine treatment in vitro. J Clin Invest. 1985;75:1538-44. CrossrefMedlineGoogle Scholar2. WybranAppelboom JT. Isoprinosine (inosiplex) immunological and clinical effects. In: Immunomodulation: New Frontiers and Advances. New York: Plenum Press; 1984. CrossrefGoogle Scholar3. TsangTangnavarad HK. Modulation of T and B lymphocyte function by isoprinosine in homosexual subjects with prodromate and in patients with acquired immune deficiency syndrome (AIDS). J Clin Immunol. 1984;4:469-77. CrossrefMedlineGoogle Scholar4. LangePaul JD. Persistent HIV antigen anemia and decline of HIV core antibodies associated with transition to AIDS. Br Med J. 1986;293:1459-63. CrossrefMedlineGoogle Scholar5. RookLane AH. Sera from HTLV-III/LAV antibody positive individuals mediate antibody-dependent cellular cytotoxicity against HTLV-III/LAV infected T cells. J Immunol. 1987;138:1064-7. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Kwong-Yok Tsang, PhD; Elizabeth A. Johnson, PhD; Mariano F. La Via, MDAffiliations: Medical University of South Carolina Charleston, SC 29425 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1988Volume 109, Issue 7Page: 595-595KeywordsAIDSAIDS related complexCellsDrugsHomosexualsLymphocytesMacrophagesNatural killer cellsT cells ePublished: 1 December 2008 Issue Published: 1 October 1988 PDF downloadLoading ...