"Post Hoc" and Hypoprothrombinemia
Authors: RAYMOND E. GALINSKY
Journal: Annals of Internal Medicine (1975)

Comments and Correction1 August 1975"Post Hoc" and HypoprothrombinemiaRAYMOND E. GALINSKY, PHARM.D., PETER J. FORNI, PHARM.D., GORDON G. MCGUIRE, PHARM.D., THEODORE G. TONG, PHARM.D., NEAL BENOWITZ, M.D., CHARLES E. BECKER, M.D.RAYMOND E. GALINSKY, PHARM.D.Search for more papers by this author, PETER J. FORNI, PHARM.D.Search for more papers by this author, GORDON G. MCGUIRE, PHARM.D.Search for more papers by this author, THEODORE G. TONG, PHARM.D.Search for more papers by this author, NEAL BENOWITZ, M.D.Search for more papers by this author, CHARLES E. BECKER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-83-2-286 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We read with great interest "Warfarin-Chloral Hydrate Interaction" by Udall (Ann Intern Med 81:341-344, 1974). The impression that warfarin and chloral hydrate can be given concomitantly without increasing the risks of hypoprothrombinemia or hemorrhagic complications appears to have been verified. We wish to report a recent experience where a single large dose of chloral hydrate given to a patient apparently stabilized on warfarin dramatically altered the anticoagulant response to the latter.A 17-year-old black man entered the San Francisco General Hospital with severe pain of the lower back of 4 days' duration. On admission, gingival bleeding was...References References1. GOLDBERT T: Comparative evaluation of treatments of alcohol withdrawal syndromes. JAMA 201:113-116, 1967 Google Scholar2. SELLERSKOCH-WESER EJ: Kinetics and clinical importance of displacement of warfarin for albumin by acidic drugs. Ann NY Acad Sci 179:213-225, 1971 CrossrefMedlineGoogle Scholar3. SELLERS E: Interaction of chloral hydrate and ethanol in man. I. Metabolism. Clin Pharmacol Ther 13:37-49, 1972 CrossrefMedlineGoogle Scholar4. SELLERSKOCH-WESER EJ: Potentiation of warfarin-induced hypoprothrombinemia by chloral hydrate. N Engl J Med 283: 827-831, 1970 CrossrefMedlineGoogle Scholar5. ORMEBRECKENRIDGEBROOKS MAR: Interactions of benzodiazepines with warfarin. Br. Med J 3:611-614, 1972 CrossrefMedlineGoogle Scholar1. KOCH-WESER J: Quinidine-induced hypoprothrombinemic hemorrhage in patients on chronic warfarin therapy. Ann Intern Med 68:511, 1968 LinkGoogle Scholar2. UDALL J: Quinidine and hypoprothrombinemia (letter). Ann Intern Med 69:403 1968 LinkGoogle Scholar3. UDALL J: Drug interference with warfarin therapy. Clin Med 77:20, 1970 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: RAYMOND E. GALINSKY, PHARM.D.; PETER J. FORNI, PHARM.D.; GORDON G. MCGUIRE, PHARM.D.; THEODORE G. TONG, PHARM.D.; NEAL BENOWITZ, M.D.; CHARLES E. BECKER, M.D.Affiliations: Acute Detoxification Unit San Francisco General Hospital San Francisco, California 94110 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1975Volume 83, Issue 2Page: 286-287KeywordsAnticoagulantsHemorrhageHydratesLower back pain ePublished: 1 December 2008 Issue Published: 1 August 1975 PDF downloadLoading ...