tbuckley/cabot-search huggingface dataset:
Syndrome of Inappropriate Antidiuretic Hormone Secretion in Advanced Age
Authors: Carl S. Goldstein, Seth Braunstein, Stanley Goldfarb
Journal: Annals of Internal Medicine (1985)

Letters and Corrections1 April 1985Syndrome of Inappropriate Antidiuretic Hormone Secretion in Advanced AgeCARL S. GOLDSTEIN, M.D., SETH BRAUNSTEIN, M.D., Ph.D., STANLEY GOLDFARB, M.D.CARL S. GOLDSTEIN, M.D.Search for more papers by this author, SETH BRAUNSTEIN, M.D., Ph.D.Search for more papers by this author, STANLEY GOLDFARB, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-102-4-563_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We previously described the case of an 88-year-old man with the syndrome of inappropriate antidiuretic hormone secretion (SIADH), without any associated disease (1). On the basis of 17 months of follow-up, we advocated that this patient had a truly idiopathic form of SIADH, expressed as chronic, asymptomatic, hypotonic hyponatremia.We are writing to extend this observation, now after a follow-up of 3 years. The patient remains hyponatremic, with serum sodium concentrations ranging from 122 to 132 meq/L. Since our original report, he has had cystoscopy to evaluate incontinence, but the test revealed no malignancy. Esophagogastroscopy was done...Reference1. GOLDSTEINBRAUNSTEINGOLDFARB CSS. Idiopathic syndrome of inappropriate antidiuretic hormone secretion possibly related to advanced age. Ann Intern Med. 1983;99:185-8. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: School of Medicine University of Pennsylvania Philadelphia, PA 19104 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySymptomatic hyponatremia as a presenting sign of hypothalamic-pituitary disease: A syndrome of inappropriate secretion of antidiuretic hormone (SIADH)-like glucocorticosteroid responsive conditionGeriatric hyponatremia 1 April 1985Volume 102, Issue 4Page: 563-563KeywordsAttentionCystoscopyHyponatremiaIncontinencePatient advocacySodiumSyndrome of inappropriate antidiuretic hormone secretion Issue Published: 1 April 1985 PDF downloadLoading ...
FDG PET/CT Repeatedly Demonstrated Hepatic Cyst Infection in a Patient With Autosomal Dominant Polycystic Kidney Disease
Authors: Chia-Tien Hsu, Horng-Rong Chang, Jong-Kang Lee, Jui-Hung Weng, Pan-Fu Kao
Journal: Clinical Nuclear Medicine (2013)

A 70-year-old man with a history of autosomal dominant polycystic kidney disease was referred for F-FDG PET/CT scans twice at 6-month intervals due to repeated fever with negative conventional imaging studies. The FDG PET/CT scans revealed different hepatic cyst lesions in the 2 scans, with a large infected cyst in the second study. After aspiration and intravenous antibiotics treatment, the patient was discharged and remained uneventful thereafter for 6 months.
Amoxicillin-clavulanic acid therapy of spontaneous bacterial peritonitis: A prospective study of twenty-seven cases in cirrhotic patients
Authors: Jean D. Grange, Xavier Amiot, Veronique Grange, Laurent Gutmann, Michel Biour, François Bodin, Raoul Poupon
Journal: Hepatology (1990)

Spontaneous bacterial peritonitis in cirrhosis is a serious complication that demands urgent attention. We report here a prospective study of the treatment of 27 episodes of spontaneous bacterial peritonitis in 22 cirrhotic patients with amoxicillin and clavulanic acid. The infection of ascitic fluid was diagnosed by a positive culture plus an ascitic neutrophil count exceeding 75/μl, or by an ascitic neutrophil count exceeding 500/μl. The infection was treated with 1 gm amoxicillin and 0.2 gm clavulanic acid every 6 hr for 14 days. In 17 cases (63%), bacteria were isolated from the ascitic fluid. All the bacteria isolated were sensitive to amoxicillin and clavulanic acid, whereas in five cases they were resistant to amoxicillin alon ( Escherichia coli in two cases, Klebsiella pneumoniae in two cases and Bacteroides fragilis in one case). Cure of the infection was achieved in 23 episodes (85%) after 14 days' treatment; 17 patients (63%) were able to leave the hospital. Fourteen of 20 patients (70%) treated for the first episode of infection died within 1 yr: eight from infection, two from gastrointestinal hemorrhage, one from infection and hemorrhage and three from tumors. One patient who had repeated infections underwent liver transplantation and has not had any infectious complications 1.5 yr after surgery. Amoxicillin and clavulanic acid may be an effective first–line therapy for ascitic fluid infection in cirrhosis. Nevertheless, the 1–yr prognosis continues to be grave and the severity of the underlying liver disease remains the most important determinant for survival. (Hepatology 1990;11:360-364.)
Relevance of Physical Activity to the Antiarrhythmic Effects of β-Blockade on Supraventricular Tachycardias
Authors: V. Hombach, H-W. Höpp, V. Braun, D. Gil-Sanchez, H. Deutsch, D.W. Behrenbeck, M. Tauchert, H.H. Hilger
Journal: Drugs (1983)
Action potential prolongation and induction of abnormal automaticity by low quinidine concentrations in canine Purkinje fibers. Relationship to potassium and cycle length.
Authors: D M Roden, B F Hoffman
Journal: Circulation Research (1985)

Marked QT prolongation with induction of polymorphous ventricular tachycardia ("Torsades de Pointes") is a well-described phenomenon during quinidine therapy, frequently occurring at low plasma quinidine concentrations, low serum potassium, and slow heart rates. We have therefore assessed the dose-electrophysiological effects of quinidine as a function of extracellular potassium and cycle length in canine Purkinje fibers, using standard microelectrode techniques. Quinidine (1 microM) prolonged action potential at 90% repolarization, while leaving phase zero upstroke slope (Vmax) unchanged at a cycle length 300-8000 msec; at 10 microM, Vmax depression became evident. Increases in the action potential at 90% repolarization were most marked at long cycle lengths and low extracellular potassium (in contrast to Vmax depression) and were partially reversed by tetrodotoxin (1 microM). The relationship between log of cycle length and action potential at 90% repolarization was linear (for cycle length 300-8000 msec) in the absence of quinidine. Quinidine increased the slope of this relationship in a concentration-related fashion, whereas increasing extracellular potassium shifted the curve rightward (without changing slope), regardless of the presence or absence of quinidine. Action potentials were also measured following pauses of 5-60 seconds. In the absence of quinidine, the action potential depolarization returned to its baseline value in a monoexponential fashion (time constant 36.0 +/- 4.9 sec, mean +/- SE, n = 10). In the presence of 1 microM quinidine, this return was better fit as a biexponential process (time constants 4.2 +/- 1.2 and 40.7 +/- 6.2 seconds, n = 14). At slow stimulation rates (cycle length greater than 4000 msec) in low extracellular potassium (2.7 mM), quinidine produced early afterdepolarizations in 7/14 (50%) of fibers at 1 microM and 14/18 (78%) at 10 microM. Early afterdepolarizations were eliminated by increasing stimulation rates, raising the extracellular the extracellular potassium concentration to 5 mM, or adding tetrodotoxin. These data suggest that prolongation by quinidine of action potentials at 90% repolarization is multifactorial, with both a "tonic" prolonging effect and a prominent frequency-dependent action potential shortening effect. At long cycle lengths and low extracellular potassium, low quinidine concentrations consistently produced early after-depolarizations. The parallels between this form of triggered activity and clinical arrhythmias induced by quinidine suggest that early afterdepolarizations may play a role in quinidine-induced Torsades de Pointes.
14/Sec and 6/Sec Spikes on Sleep EEG as Normal Finding in Stage REM
Authors: Ekkehard Othmer
Journal: JAMA (1974)

<h3>To the Editor.—</h3> Abnormal 14/sec and 6/sec spikes have been considered to be associated with a variety of behaviors and neurologic problems. These include violence without subsequent remorse, school difficulties, vegetative symptoms, central nervous system trauma, and muscular dystrophy. Other authors have questioned these findings. Small,<sup>1</sup>for instance, found them in 5% of hospitalized adult psychiatric patients, but they were not associated with symptoms reported in the literature. In our laboratory, we have had the opportunity to record longer (eight-hour) sleep electroencephalograms on a nonpatient population, and have concluded that these abnormal spikes represent a normal finding related to a specific sleep stage. Thirty-four subjects (25 men, 9 women) ranging in age from 18 to 28 were recorded from 10 PM to 6 AM for use as normal controls for pharmacologic studies. Each was interviewed by a psychiatrist who found no gross evidence of psychiatric illness and no history
Remarks ON THE THERAPEUTIC VALUE OF COMPLETE VOCAL REST DURING THE SANATORIUM TREATMENT OF LARYNGEAL TUBERCULOSIS
Authors: F. Semon
Journal: BMJ (1906)

t Iu tlle following the reading of this paper Dr. Lublinski claimed tirat lie too had recommended complete vocal the treatnient of tuberculosis as far back as 1887.Whilst willingly registep-ing tis fact, it seems hardly necessary for me to point out that tis paper was not intended to give a full historical retrospect of tire wliole question.and that its only purpose is to empliasize the value of complete silence in certaincanes of laryngeal tuberculosis during eanatorium treatment.r Tm zznm i623 8 Ulml"T.70VMAZ VOCIL RE"!"'IT IN LIRYNGE!&L TUBERCULOSIS.
NrasG12D/+ promotes leukemogenesis by aberrantly regulating hematopoietic stem cell functions
Authors: Jinyong Wang, Guangyao Kong, Yangang Liu, Juan Du, Yuan-I Chang, Sin Ruow Tey, Xinmin Zhang, Erik A. Ranheim, Marc K. Saba-El-Leil, Sylvain Meloche, Alisa Damnernsawad, Jingfang Zhang, Jing Zhang
Journal: Blood (2013)
Solitary Brain Met, Resected
Authors: GREG FRIESS
Journal: Annals of Internal Medicine (1986)

Ad Libitum1 April 1986Solitary Brain Met, ResectedGREG FRIESS, D.O.GREG FRIESS, D.O.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-104-4-592_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Excerpt"Tell me, John, was it worth it?"He moved his hand still paralyzedPast his face, past his eyesTo where the hair was growing backTo the healing surgical flap."Let's get the bastard," he'd grinned so fastA month ago, so long ago,He'd been sure when I was not,But melanoma the miser gave few options.His eyes held mine so steadily,The words were eager the words were ready,But lips and tongue were slow to reply,Words and wit left standing by.His eyes now showed their deep fatigue.A month ago, so long ago.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Fort Sam Houston, Texas PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1986Volume 104, Issue 4Page: 592-592KeywordsBrainFatigueMelanomaTongue ePublished: 1 December 2008 Issue Published: 1 April 1986 PDF downloadLoading ...
BLACK RACE ASSOCIATED WITH WORSE OUTCOMES IN AMBULATORY HEART FAILURE-PRESERVED EJECTION FRACTION PATIENTS
Authors: Eldrin F. Lewis, Brian Claggett, JianKang Liu, Robin Boineau, Akshay Desai, Scott Solomon, Inderjit Anand, Nancy Sweitzer, Jean L. Rouleau, James Fang, Cynthia Thaik, Eileen O’Meara, Tamrat M. Retta, Nadine Clausell, Sonja McKinlay, Bertram Pitt, Marc Pfeffer
Journal: Journal of the American College of Cardiology (2015)
Combination Treatment of Murine Tumors by Adenovirus-Mediated Local B7/IL12 Immunotherapy and Radiotherapy
Authors: Frank Lohr, Kang Hu, Zishan Haroon, Thaddeus V. Samulski, Qian Huang, Jennifer Beaty, Mark W. Dewhirst, Chuan-Yuan Li
Journal: Molecular Therapy (2000)

Failure of local tumor control still poses a problem for radiotherapy and translates into reduced survival. Combining radiation with chemotherapy or other newer modalities has shown promising results. Immunological approaches to tumor therapy have found renewed interest due to improved insight into mechanisms involved in the immune response to tumors. In this paper, we studied tumor growth delay after various combination regimens of locally injected adenovirus constitutively expressing IL12 and B7.1 (AdIL12/B7.1) and fractionated radiotherapy in two nonimmunogenic murine tumor models, 4T1 and B16.F10. Effects of radiation and virus infection on surface antigen expression in these tumor lines were assessed. Mechanisms of action of AdIL12/B7.1 were studied by conducting additional experiments with and without depletion of NK-cells and/or T-cells, and by cytotoxic T-lymphocyte assays, and immunohistochemical evaluation of tumor blood vessels. Both B7.1 and IL12 were effectively expressed in both irradiated and unirradiated 4T1 and B16.F10 tumor cells but did not add significantly to radiation-induced cell killing in vitro. However, local tumor infection by AdIL12/B7.1 after irradiation significantly increases the effectiveness of radiotherapy when applied after completion of radiotherapy. The mechanism appears to be complicated, involving a host of factors that included the ability of IL12 to activate T-cells and NK-cells and to inhibit angiogenesis and the ability of radiation to induce apoptosis or necrosis among tumor cells. These data support the combination of radiotherapy with adenovirus-mediated immunotherapy and suggest that the concept of adding genetic immunotherapy after radiotherapy in a combined regimen merits further study.
Erythrocyte Adherence to Endothelium in Sickle-Cell Anemia
Authors: Robert P. Hebbel, Marc A. B. Boogaerts, John W. Eaton, Martin H. Steinberg
Journal: New England Journal of Medicine (1980)

We studied 33 patients with sickle-cell anemia to examine the possible relation between the severity of their disease (frequency of microvascular occlusions) and the abnormal adherence of sickle erythrocytes to cultured human endothelium. Neither clinical severity nor erythrocyte adherence correlates significantly with red-cell indexes, hemoglobin concentration, percentage of irreversibly sickled red cells, level of fetal hemoglobin, or reticulocyte count. However, clinical severity and erythrocyte adherence are strongly correlated (rank correlation coefficient = +0.666; P less than 0.001). These findings are consistent with the hypothesis that abnormal interactions between erythrocytes and endothelium may be the initiating factor in the development of microvascular occlusions in sickle-cell anemia.
Resolutions of the North of England Medical Association on the same Bill
Authors: Chas. T. Carter
Journal: BMJ (1840)

MEDICAL REFORML-MRWARBURTON'S BILL.of each twelve, 4 persons are to be chosen from the non- medical division."Why non-medical men are to be admitted members of a council, whose office is to form by-laws for, and regulate the affairs of, the medical profession, I am at a loss to conceive ; and why the secretary of state is to interfere in the business, I am equally unable to comprehend; but the whole bill from beginning to end is a mischievous, trumpery farrago, and the most shameful insult to the members of the medical profession I ever perused, and is, doubtless, intended to overthrow all the existing medical and surgical colleges and universities in the United Kingdom.But this, I trust, will not be so easily accomplished, if each of the several members of the Royal Colege of Surgeons, in London, will bear in mind the oath he took when he obtained his diploma, " to support to the utmost of his power the dignity and welfare of the college."And I trust the heads of the profession, the members of the councils of the several royal colleges of physicians and surgeons in her inajesty's dominions, will view the matter in its proper light, and crush the monster ere it breathe.Having, Gentlemen, thus done what I conceived to be my duty, in exposing the faults of this bill, I subscribe myself, Gentlemen, your very obedient servant,
1002 PHARMACOKINETIC STUDIES ON A NOVEL HBV ENTRY INHIBITOR MYRCLUDEX B DEMONSTRATE HBV-RECEPTOR EXPRESSION IN RODENTS AND DOGS BUT NOT IN CYNOMOLGUS MONKEYS
Authors: A. Schieck, A. Meier, A. Alexandrov, C. Leder, P. Romeis, U. Haberkorn, W. Mier, S. Urban
Journal: Journal of Hepatology (2010)
Somatostatin Receptor Imaging With a Technetium-Labeled Peptide: Comparison With Indium-111 Pentetreotide
Authors: C. Love, M. B. Tomas, D. Gutleber, Y. M. Baran, C. J. Palestro
Journal: Clinical Nuclear Medicine (1998)

Love, C.; Tomas, M. B.; Gutleber, D.; Baran, Y. M.*; Palestro, C. J. Author Information
Helper-independent and AAV-ITR-independent chromosomal integration of double-stranded linear DNA vectors in mice
Authors: Hiroyuki Nakai, Eugenio Montini, Sally Fuess, Theresa A Storm, Leonard Meuse, Milton Finegold, Markus Grompe, Mark A Kay
Journal: Molecular Therapy (2003)

Nonviral plasmid DNA is a promising vector for achieving ex vivo and in vivo gene transfer. However, transgene expression is usually transient, especially in dividing target cells due to loss of vector genomes. Here we describe the use of naked double-stranded (ds) linear DNA as a way to insert exogenous DNA sequences into chromosomes of mouse hepatocytes in vivo, without helper components such as integrase or transposase. We constructed ds linear DNA vectors with or without adeno-associated virus inverted terminal repeats (AAV-ITRs), introduced them into mouse hepatocytes in vivo using a hydrodynamics-based transfection technique, and analyzed for vector genome integration in various ways. Surprisingly, these linear DNA molecules integrated in mouse hepatocytes in vivo at a level of 0.3-0.5 vector genome, or more, per diploid genomic equivalent irrespective of the AAV-ITR sequences. Our results establish a novel and simple way to engineer chromosomes in vivo and provide further insights into the mechanisms of recombinant AAV vector integration in vivo. In addition, they may provide a clue for developing new nonviral integrating gene delivery vector systems.
Inverse association between appendicectomy and ulcerative colitis
Authors: Morten Frisch
Journal: BMJ (2006)

authorities demanding their collusion in unethical behaviour is illustrated by the recent successful, possibly permanent, suspension of capital punishment in California after a refusal by doctors to administer lethal injections. 14 Lifton has shown the ease with which doctors can drop their ethical guard, in ways that do not have to be as stark as the horrors of Guantanamo Bay. 1 National and international medical bodies need to understand that not only do they have more power than they generally assume, or choose to use, but that to use that power is a basic ethical duty.This duty is as basic as the application of ethical principles in the daily life of a practising doctor.
INFLUENCE OF RENAL SYMPATHETIC DENERVATION ON VASCULAR INFLAMMATION IN ESSENTIAL HYPERTENSION
Authors: Oliver Dörr, Christoph Liebetrau, Helge Möllmann, Luise Gaede, Christian Troidl, Jens Wiebe, Nikolai Busch, Marko Dahmer, Jedrzej Hoffmann, Timm Bauer, Christian Hamm, Holger Nef
Journal: Journal of the American College of Cardiology (2014)
SIRT1 deficiency compromises mouse embryonic stem cell hematopoietic differentiation, and embryonic and adult hematopoiesis in the mouse
Authors: Xuan Ou, Hee-Don Chae, Rui-Hong Wang, William C. Shelley, Scott Cooper, Tammi Taylor, Young-June Kim, Chu-Xia Deng, Mervin C. Yoder, Hal E. Broxmeyer
Journal: Blood (2010)
Sir Thomas Browne
Authors: F. S. Jarvis
Journal: JAMA (1963)

To the Editor:—  Many doctors throughout the world know that Sir Thomas Browne, when his Religio Medici was published, was living in Norwich, England, the city in which he worked as a family doctor for 46 years. Here he wrote his Urn Burial and other books, and was knighted when Charles II visited Norwich in 1671. He died in 1682 and was buried, as was his wife 2 years later, in the parish church of St. Peter Mancroft, where the family had worshipped for many years.  Browne's writings have been read and admired by generations of doctors, not least renowned amongst these being Sir William Osler, whose devotion to Browne was unbounded. Sir William visited Norwich early in this century and was shocked to find the skull of his favorite author casually on the shelves of the museum in the Norfolk and Norwich Hospital. (It had been knaved out of
Causes and Effects of Surgical Delay in Patients With Hip Fracture
Authors: María T. Vidán, Elisabet Sánchez, Yassira Gracia, Eugenio Marañón, Javier Vaquero, José A. Serra
Journal: Annals of Internal Medicine (2011)

The clinical effect of surgical delay in older patients with hip fracture is controversial. Discrepancies among study findings may be due to confounding that is caused by the reason for the delay or a differential effect on patient risk subgroups.To assess the effect of surgical delay on hospital outcomes according to the cause of delay.Prospective cohort study.A hip fracture unit in a university hospital in Spain.2250 consecutive elderly patients with hip fracture.Time to surgery, reasons for surgical delay, adjusted in-hospital death, and risk for complications.Median time to surgery was 72 hours. Lack of operating room availability (60.7%) and acute medical problems (33.1%) were the main reasons for delays longer than 48 hours. Overall, rates of hospital death and complications were 4.35% and 45.9%, respectively, but were 13.7% and 74.2% in clinically unstable patients. Longer delays were associated with higher mortality rates and rates of medical complications. After adjustment for age, dementia, chronic comorbid conditions, and functionality, this association did not persist for delays of 120 hours or less but did persist for delays longer than 120 hours (P = 0.002 for overall time effect on death and 0.002 for complications). The risks were attenuated after adjustment for the presence of acute medical conditions as the cause of the delay (P = 0.06 for time effect on mortality and 0.31 on medical complications). Risk for urinary tract infection remained elevated (odds ratio, 1.54 [95% CI, 0.99 to 2.44]). No interaction between delay and age, dementia, or functional status was found.This was a single-center study without postdischarge follow-up.The reported association between late surgery and higher morbidity and mortality in patients with hip fracture is mostly explained by medical reasons for surgical delay, although some association between very delayed surgery and worse outcomes persists.None.