Cimetidine Decreases Theophylline Clearance
Authors: MARK A. CAMPBELL
Journal: Annals of Internal Medicine (1981)

Brief Reports1 July 1981Cimetidine Decreases Theophylline ClearanceMARK A. CAMPBELL, B.S., R.Ph., JOHN R. PLACHETKA, Pharm.D., J. EDWARD JACKSON, M.D., JAMES F. MOON, M.D., PAUL R. FINLEY, M.D.MARK A. CAMPBELL, B.S., R.Ph.Search for more papers by this author, JOHN R. PLACHETKA, Pharm.D.Search for more papers by this author, J. EDWARD JACKSON, M.D.Search for more papers by this author, JAMES F. MOON, M.D.Search for more papers by this author, PAUL R. FINLEY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-95-1-68 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCimetidine, an H-2 receptor antagonist, was introduced in the United States in 1977 for the treatment of duodenal ulcers. Since its introduction, approximately 11 million patients worldwide have been treated with Cimetidine (1). In 1980, Cimetidine was the 15th most commonly prescribed drug in the United States (2). Recently, numerous drug interactions involving Cimetidine have been reported; it has been shown to decrease the clearance of antipyrine, diazepam, and warfarin in humans (3, 4), as well as prolong hexobarbital sleep time and inhibit aminopyrine and caffeine demethylation in rats (5, 6). Recently, prophylactic Cimetidine has been recommended for ulcer patients...References1. DAVISPICKETTSCHLOSSER TDJ. Evaluation of a worldwide spontaneous reporting system with cimetidine. JAMA. 1980;243:1912-4. CrossrefMedlineGoogle Scholar2. The top 200 drugs. Pharmacy Times. 1981;47:17-25. Google Scholar3. KLOTZANTTILAREIMANN UVI. Cimetidine/diazepam interaction. Lancet. 1979;2:699. Letter. CrossrefMedlineGoogle Scholar4. SERLINMOSSMANSIBEON MSR. Cimetidine: interaction with oral anticoagulants in man. Lancet. 1979;2:317-9. CrossrefMedlineGoogle Scholar5. PUURUNENPELKONEN JO. Cimetidine inhibits microsomal drug metabolism in the rat. Eur J Pharmacol. 1979;55:335-6. CrossrefMedlineGoogle Scholar6. DESMONDPATWARDHANPARKERSCHENKERSPEEG PRRSK. Effect of cimetidine and other antihistaminics on the elimination of aminopyrine, phenacetin, and caffeine. Life Sci. 1980;26:1261-8. CrossrefMedlineGoogle Scholar7. FOSTERTRUDEAUGOLDMAN LWA. Bronchodilator effects on gastric acid secretion. JAMA. 1979;241:2613-5. CrossrefMedlineGoogle Scholar8. POWELLJACKSON JJ. Counterpoint discussion: theophylline. In: EVANS WE, SCHENTAG JJ, JUSKO WJ, eds. Applied Pharmacokinetics. San Francisco: Applied Therapeutics, Inc.; 1980; 139-66. Google Scholar9. JACKSONPOWELLWANDELLBENTLEYDORR JJMJR. Cimetidine-theophylline interaction. Am Rev Respir Dis. 1981. In press. Google Scholar10. JACOBSSENIORKESSLER MRG. Clinical experience with theophylline: relationships between dosage, serum concentration, and toxicity. JAMA. 1976;235:1983-6. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Colleges of Pharmacy and Medicine University of Arizona Arizona Health Sciences Center Tucson, Arizona PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMedical issues and emergencies in the dermatology officePharmacological Interactions in the Perioperative PeriodConcerning drug interactions with theophyllineHepatic Diseases in the ElderlyTheophylline and Antiparasitic Drug InteractionsThe Influence of Intravenous Cimetidine Dosage Regimens on the Disposition of TheophyllineThe influence of ofloxacin and enoxacin on the metabolic pathways of theophylline in healthy volunteersWhy plaintiffs' counsel challenge tests, and how they can successfully challenge the theory of “validity generalization”Role of Extracorporeal Drug Removal in Acute Theophylline PoisoningLack of interaction of ranitidine with amitriptylineComparison of Two Sustained-Release Theophylline Preparations in Adult Patients With Obstructive Airways DiseaseUsefulness and safety of cimetidine in patients receiving mexiletine for ventricular arrhythmiaCimetidine interaction with amitriptylineTheophylline PharmacotherapyDifferential effects of cimetidine on theophylline metabolic pathwaysCimetidine-drug interactionsEinflu� von Histamin H2-Rezeptorantagonisten auf die hepatische Elimination von ArzneimittelnEffect of Cimetidine on Phenytoin Serum LevelsPharmacokinetics in anaesthesiaCimetidine inhibits theophylline clearance in patients with chronic obstructive pulmonary disease: a study using stable isotope methodology during multiple oral dose administration.Review of Cimetidine Drug InteractionsTheophylline A “State of the Art” ReviewAntihistaminesEtat confusionnel grave lors de l'association théophylline-cimétidineComparative Pharmacokinetic Changes and Drug Therapy in an Older PopulationLack of effect of cimetidine on action of phenprocoumonCimetidine-Theophylline InteractionROBERT J. CLUXTON JR, PHARM.D., JOSÉ O. RIVERA, PHARM.D., WOLFGANG A. RITSCHEL, PH.D., AMADEO J. PESCE, PH.D., IRWIN B. HANENSON, M.D.Cimetidine as an Inhibitor of Drug Metabolism: Therapeutic Implications and Review of the LiteratureCimetidine-Theophylline-TerbutalineA. SIDNEY BARRITT, M.D.Cimetidine in Elderly PatientsThe Interaction of Cimetidine and TheophyllineMore on Cimetidine — Theophylline InteractionEffects of Drugs and Diet on Theophylline Phamacokinetics 1 July 1981Volume 95, Issue 1Page: 68-69KeywordsCaffeineDiazepamDrug interactionsDrugsDuodenal ulcersSleepUlcers Issue Published: 1 July 1981 PDF downloadLoading ...