tbuckley/cabot-search huggingface dataset:
Obstetrical and Neonatal Outcome following Clonazepam Use during Pregnancy: A Case Series
Authors: Lisa Weinstock, Lee S. Cohen, Jennie W. Bailey, Robert Blatman, Jerrold F. Rosenbaum
Journal: Psychotherapy and Psychosomatics (2001)

&lt;i&gt;Background:&lt;/i&gt; Given the high prevalence of panic disorder in women, treatment decisions are frequently made regarding the use of anti-panic medications during the childbearing years and during pregnancy. The objective of this case series was to evaluate obstetric and neonatal outcome associated with treatment with clonazepam during pregnancy. &lt;i&gt;Methods:&lt;/i&gt; Subjects were 38 women with histories of panic disorder who used clonazepam during pregnancy. Information regarding the amount and duration of clonazepam use during pregnancy was obtained. Obstetrical records describing pregnancy, labor and delivery and infant Apgar scores were obtained for all subjects. Neonatal nursery records were obtained for 27 subjects. &lt;i&gt;Results:&lt;/i&gt; Maternal outcome assessed by obstetrical records and acute neonatal outcome assessed by Apgar scores were positive. Based on neonatal records, there were no cases of orofacial anomalies, neonatal apnea, benzodiazepine withdrawal syndromes, or temperature or other autonomic dysregulation. In 2 infants born to the same mother, use of clonazepam and imipramine at the time of delivery was associated with transient neonatal distress. &lt;i&gt;Conclusion:&lt;/i&gt; Clonazepam use during pregnancy did not appear to be directly related to any obstetric complications during pregnancy, labor, or delivery. There was no evidence of neonatal toxicity or withdrawal syndromes in babies born to mothers who took clonazepam during pregnancy. Absence of serious maternal or neonatal compromise following clonazepam use during pregnancy in these mothers and infants is somewhat reassuring. One case of hypotonia and 1 case of respiratory distress in babies who were exposed to clonazepam in combination with imipramine at the time of delivery may suggest that coadministration of benzodiazepines with other psychotropic medications may require close neonatal observation.
Low Medial and Lateral Right Pulvinar Volumes in Schizophrenia: A Postmortem Study
Authors: J. Robin Highley, Mary A. Walker, Timothy J. Crow, Margaret M. Esiri, Paul J. Harrison
Journal: American Journal of Psychiatry (2003)

OBJECTIVE: In this study, the volume and neuronal number of the pulvinar thalamic nucleus in schizophrenia patients were measured. METHOD: The authors examined medial and lateral pulvinar nuclei bilaterally in 27 patients with schizophrenia and 28 normal comparison subjects. RESULTS: In the comparison subjects, the medial pulvinar was larger on the right. The right but not left pulvinar nuclei were smaller in the schizophrenia patients than in the comparison subjects. The number of neurons showed similar trends. CONCLUSIONS: These findings confirm low pulvinar volume in schizophrenia and show that it affects both medial and lateral nuclei. The lateralized findings may reflect pulvinar connections with asymmetrical neocortical regions and their asymmetrical involvement in schizophrenia.
Non-invasive continuous finger blood pressure measurement during orthostatic stress compared to intra-arterial pressure
Authors: B. P M Imholz, J. J Settels, A. H van der Meiracker, K. H Wesseling, W. Wieling
Journal: Cardiovascular Research (1990)

Journal Article Non-invasive continuous finger blood pressure measurement during orthostatic stress compared to intra-arterial pressure Get access Ben P M Imholz, Ben P M Imholz Correspondence to: Dr B P M Imholz (room F4-257) Search for other works by this author on: Oxford Academic PubMed Google Scholar Jos J Settels, Jos J Settels Search for other works by this author on: Oxford Academic PubMed Google Scholar Anton H van der Meiracker, Anton H van der Meiracker Search for other works by this author on: Oxford Academic PubMed Google Scholar Karel H Wesseling, Karel H Wesseling Search for other works by this author on: Oxford Academic PubMed Google Scholar Wouter Wieling Wouter Wieling Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 24, Issue 3, March 1990, Pages 214–221, https://doi.org/10.1093/cvr/24.3.214 Published: 01 March 1990 Article history Received: 30 August 1989 Accepted: 31 October 1989 Published: 01 March 1990
Large Cyst of the Mesentery Simulating an Ovarian Cyst: Operation: Death
Authors: C. H. Carter
Journal: BMJ (1883)

complained in no way of the bowel, exept when constipated, when he also had a little pain at the upper part of the sacrum.There was no trace of recurrence anvwhere, but a little recontraction had taken place since last seen-in May.-The bowel, however, still adlmitted the index finger well beyond the narrow spot, and above this all was healthy.This case appears very encouraging, as showing, like many others recorded, in the first place, the possibility and (lesirabilit.y of an early diagnosis of cancer of the rectum; and in the next, the feasi- bility of its conmpletc removal with safety to the patient in properly selected cases.I have requested this patient to present himself occasionally at hospital for examination, and shall report fuirther as to his condition, bhoUild there be any recurrence.
Two cases of pegylated asparaginase‐associated severe and persistent hyperbilirubinemia
Authors: Sara Kim
Journal: American Journal of Hematology (2009)

Langerhans cell histiocytosis following acute leukemia in an adultTo the editor: A 69-year-old man presents with cough and SOB approximately 3.5 years following diagnosis of a poorly differentiated acute lymphocytic leukemia (progenitor cell phenotype).By flow cytometry, the initial leukemia in 1998 was positive for HLA-DR, CD34, and CD45 and negative for lymphoid and myeloid markers including: CD3, CD5, CD7, CD19, CD10, CD20, CD13, CD33, CD11b, and CD14; CD1a and S-100 protein staining were not available on this sample.A pathologic diagnosis of a progenitor cell leukemia most suggestive of acute lymphocytic leukemia was made.The patient received induction therapy in November 1998 and achieved a complete remission.Consolidation therapy was discontinued after one cycle due to severe cytopenias.Maintenance therapy was discontinued after 6 months secondary to methotrexate-induced hepatoxicity.Approximately 3.5 years after the initial diagnosis, the patient presented with back pain and leg weakness and found to have a paraspinal mass with cord compression.He underwent surgical resection followed by consolidative radiation.The lesion (see Fig. 1) was composed of sheets of medium to large sized mitotically active cells with relatively abundant cytoplasm.Occasional multinucleated tumor giant cells were also identified.The cell nuclei were vesicular with irregular contour and occasional grooves.Considering the remote history of a lymphocytic leukemia and the morphologic features which raised the possibility of an epithelioid/dendritic cell neoplasm, a panel of immunohistochemical stains was used to characterize the lesion.The tumor cells were positive for vimentin, CD1a, S-100 protein, CD43 and focally for keratins, CD45, CD68, and lysozyme.Negative immunostains included EMA, Melan-A, CD3, CD20, CD21, CD35, Kappa and Lambda light chains, and MPO.Leder's histochemical stain was negative.Based on the morphology and the immunohistochemical profile, a diagnosis of a dendritic cell neoplasm most consistent with Langerhans cell sarcoma was rendered.Electron microscopic studies were not performed.Bone marrow biopsy revealed trilineage hematopoiesis with no evidence of leukemic involvement.Approximately 2 months later, he developed a similar soft tissue mass in the right upper chest extending into the right supraclavicular area.Radiation treatment resulted in a complete clinical response in the chest mass and he had no evidence of progression for 1 year.The patient then developed shortness of breath and fevers.A CXR showed a right
Surgeons in the United States-Reply
Authors: Walter W. Hauck
Journal: JAMA (1977)

In Reply.—  From the tenor of Dr Brown's letter, we would judge that he is one of the busier surgeons. However, our data, obtained from a large sample of all US surgeons, showed that most had only modest work loads. This is supported by the data from the questionnaire study that appeared inThe Journal, as well as other analyses that were not published because of space limitations. In particular, 23% of the surgical specialists reported that they had performed fewer than 100 operations during the year previous to the study. The figure of 200 operations per year mentioned by Dr Brown was about 15% higher than the median operations load (170) for all surgeons. Also, the surgeons reported that, on average, 50% of their office patients consulted them for nonsurgical illnesses.  Data from our companion area studies (N Engl J Med295:921-926, 982-989, 1976) also support the conclusion of low
Empyema of the gall bladder - reappraisal of a neglected disease.
Authors: J R Thornton, K W Heaton, H J Espiner, W K Eltringham
Journal: Gut (1983)

Thirty two patients with empyema of the gall bladder were identified among 1327 cases of gall-bladder disease presenting to one hospital over a six year period. Abdominal pain had been present for a median of eight days and, in eight cases, for between one and four months. In a few cases, the disease was painless and was discovered unexpectedly at postmortem or at operation for unrelated disease. The serious nature of the complaint was belied by the often scanty physical signs. Less than half the patients had a pyrexia of more than 37.5 degrees C and the presence of sepsis was rarely suspected clinically. Eight patients (25%) died, usually from unsuspected septicaemia. This considerable mortality might be reduced by the wider use of blood culture in cases of apparent 9cholecystitis9 and by greater awareness that empyema of the gall bladder is sometimes chronic, painless, and afebrile.
1129 IRON OVERLOAD INCREASES SYMPATHETIC NERVOUS ACTIVITY: STUDY IN HEMOCHROMATOSIS PATIENTS AT DIAGNOSIS AND IRON DEPLETION
Authors: R. Mariani, A. Piperno, P. Trombini, S. Coletti, M. Pozzi, G. Seravalle, F. Quarti-Trevano, G. Grassi, G. Mancia
Journal: Journal of Hepatology (2010)
Abstract 2318: Induction of Rac1b by MMP-3 causes lung tumors by activating EMT
Authors: Melody L. Stallings-Mann, Ying Zhang, Erin Miller, Derek Radisky
Journal: Cancer Research (2010)

Abstract During development, epithelial cells acquire mesenchymal characteristics through a process known as epithelial-mesenchymal transition (EMT). Substantial evidence now exists that EMT-related processes play a major role in tumor progression. EMT is a focus of interest in lung cancer as loss of E-cadherin expression confers increased resistance to several types of chemotherapy. In previous studies, we found that matrix metalloproteinase-3 (MMP3) induced EMT in mouse mammary epithelial cells through induction of Rac1b, an alternatively spliced isoform of Rac1. We now show that exposure to MMPs stimulates Rac1b and induction of EMT markers in human lung cancer cell lines, and that knockdown of Rac1b blocks MMP induced EMT. We also show that Rac1b expression levels in human lung tumor biopsies is predictive of patient outcome, and that Rac1b and MMP expression levels are correlated in these samples, suggesting a direct relationship. We also describe the generation of new transgenic mouse models for which MMP3 or Rac1b is inducibly expressed in lung epithelial cells; activation of kRAS in these mice reveals that expression of MMP3 or Rac1b promotes increased tumor number, size, and progression to adenocarcinoma as well as increased expression of EMT markers vimentin, sm-actin, col1a1, and Snail. We also show that expression of Rac1b in lung epithelial cells leads to spontaneous adenocarcinoma formation. These results demonstrate a direct linkage between induction of EMT and tumor progression, implicate Rac1b as a key mediator of these processes, and demonstrate that MMPs can directly stimulate all of these events. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2318.
Predictors of Outcome and Long-term Survival in Patients with Pleural Infection
Authors: CHRISTOPHER W. H. DAVIES, SUSAN E. KEARNEY, FERGUS V. GLEESON, ROBERT J. O. DAVIES
Journal: American Journal of Respiratory and Critical Care Medicine (1999)

In pleural infection, medical treatment failure (chest-tube drainage and antibiotics) requires surgery and increases mortality. It would be helpful to predict which patients will fail this approach. We examined clinical predictors in 85 consecutive patients with pleural infection receiving chest drainage and intrapleural fibrinolytics, and recorded age, length of history, antibiotic delay and choice, time to drainage, blood/pleural fluid (PF) bacteriology, PF pH, lactate dehydrogenase (LDH), glucose and appearance, effusion size, pleural thickness on computed tomographic (CT) scan, and survival from time of drainage. Failures (surgery/death) were compared with successes. There were 13 (15%) medical failures. PF purulence was more frequent in medical failures (10 of 13 versus 29 of 72 successes, p < 0.02 chi-square). Absence of purulence was a useful predictor of success (positive predictive value [PPV] 93%). Purulence was not useful in predicting medical failure (PPV 26%). There was a trend for positive blood culture to predict failure (5 of 13 failures versus 11 of 72 successes, p = 0.05 chi-square), but no significant differences in other endpoints. Twelve (14%) patients died in follow-up, all with comorbidity within 400 d after drainage. Probability of survival at 4 yr was 86%. Of endpoints considered in this study, PF purulence was the only useful predictor of outcome with medical therapy in pleural infection. There is good long-term survival from pleural infection.
Dying and Decision Making — Evolution of End-of-Life Options
Authors: Timothy E. Quill
Journal: New England Journal of Medicine (2004)

I recently helped my father to die. He was an engineer, independent, always on the go and in charge. He began to deteriorate rapidly from an ill-defined dementing illness, and his confusion and intermittent agitation did not respond to the standard treatments that were tried. He had made his wishes clear about avoiding any prolongation of his dying, but now he had lost the capacity to make decisions for himself. Furthermore, we did not know whether his remaining life span was measured in months or years. He was unable to sleep or relax at night, despite trials of neuroleptics, antidepressants, . . .
Plasma homocysteine concentrations in patients with type 1 diabetes.
Authors: C C Cronin, J M McPartlin, D G Barry, J B Ferriss, J M Scott, D G Weir
Journal: Diabetes Care (1998)

To determine the plasma concentration of total homocysteine (tHcy), a recognized risk factor for vascular disease, in patients with type 1 diabetes and to examine the relationships with age, sex, duration of diabetes, microvascular complications and neuropathy, and folic acid concentration.Plasma tHcy and folic acid concentrations were measured in a randomly selected cohort of type 1 diabetic patients (n = 119), well characterized as regards microvascular complications, and in a matched control group (n = 51).Plasma tHcy was higher in male than in female control subjects (geometric mean [95% CI]: 9.3 [8.0-10.9] vs. 6.1 [5.2-7.2] micromol/l, P < 0.001), as previously described, but there was no sex difference in diabetic patients. Plasma tHcy significantly correlated with age in patients (r = 0.348, P < 0.01) but not in control subjects (r = 0.007, P = 0.96). Male patients without microvascular complications had lower plasma tHcy concentrations than did male control subjects (6.2 [5.1-7.5] vs. 9.3 [8.0-10.9] micromol/l, P < 0.001), but values in female patients without complications were similar to those of female control subjects. Plasma folic acid concentration was higher in diabetic patients than in control subjects. The expected negative association between plasma tHcy and folic acid was stronger in control subjects than in patients.Subnormal tHcy concentrations in male patients, the absence of a sex difference, and the positive association with age indicate that homocysteine metabolism differs between type 1 diabetic patients and control subjects. Homocysteine is unlikely to be of pathogenic significance in patients, particularly male subjects, with early microvascular disease and/or neuropathy.
Diagnosis of Carbon Monoxide Poisoning
Authors: John H. Eckfeldt
Journal: JAMA (1978)

To the Editor.—  In a recent article (239:1515, 1978) Kelley and Sophocleus point out the difficulty in making the clinical diagnosis of carbon monoxide poisoning. They emphasize that ophthalmoscopy should always be performed in patients with nausea, headache, and dizziness, and that retinal hemorrhages should suggest the possibility of CO poisoning. Following their recommendations will certainly add to the clinical examination of such patients, but I believe several statements in their article are confusing regarding the laboratory diagnosis of CO poisoning.  In several places the authors refer to serum CO measurements. Clearly, anticoagulated whole blood, rather than a clotted serum tube, is the proper specimen to submit to the laboratory, since virtually all the CO in the  is tightly bound to the RBC's hemoglobin.  Furthermore, the authors report that blood gas analysis showed a carbon monoxide saturation value of 27%. The implication of this statement, though perhaps not intentional,
6-MONTHS OUTCOMES OF THE PLACLITAXEL ELUTING BALLOON FOR THE TREATMENT OF IN-STENT RESTENOSIS AND SMALL VESSEL DISEASE: INSIGHTS FROM THE SPANISH MULTICENTER REGISTRY
Authors: beatriz vaquerizo, Antonio Serra, Faustino Miranda, Vanesa Martinez, Jose Antonio Gómez-Hospital, Angel Cequier, Andrés Iñiguez, José Antonio Baz, Guillermo Bastos, Eduardo Fernández, Oriol Rodríguez, Josepa Mauri, Mario Sádaba, José Ramón Rumoroso, Asier Subinas, Rafael Gracía-Borbolla, Antonio Gómez, Jesús Oneto, Antonio Martínez, Francisco Bossa, Sara Rodríguez, Raul Moreno, Alejandro Saez
Journal: Journal of the American College of Cardiology (2010)
Optical mapping of the thoracoabdominal wall.
Authors: A J Peacock, M D Morgan, S Gourlay, C Turton, D M Denison
Journal: Thorax (1984)

An optical technique has been developed for mapping the size and shape of the thoracoabdominal wall and the change in its shape with breathing. A fixed pattern composed of stripes of light is projected on to both sides of the trunk. These stripes become distorted when viewed from in front and behind, forming contours over the trunk surface. The contours are photographed and then encoded digitally. The digital information can be used to compute automatically the volume of the trunk, the position of any point on its surface, and its cross sectional shape at any level. The technique has been tested on rigid objects (a globe, a cone, and two dummy torsos) that can be measured precisely. With this optical technique linear dimensions can be calculated to within 0.5 mm, cross sectional area to within 5%, and volume to within 1.6-3.7%. These results suggest that this non-invasive technique measures the shape and volume of complex three dimensional surfaces with sufficient accuracy to be tried in clinical practice.
Novel concepts of sleep-wakefullness and neuronal information coding
Authors: Thaddeus J. Marczynski
Journal: Behavioral and Brain Sciences (2000)

A new working hypothesis of sleep-wake cycle mechanisms is proposed, based on ontogeny and functional/anatomic compression of two stochastic neuronal models of information coding that complement each other in a key/lock fashion: the axonal arbor patterns (AAP – “hardware”) and the neuronal spike interval inequality patterns (SIIP – “software”). [Hobson et al.; Nielsen; Revonsuo; Solms; Vertes &amp; Eastman]
Axillary Extra Mammary Tissue
Authors: Glen Hait
Journal: JAMA (1982)

<h3>To the Editor.—</h3> I must take strong issue with the answer that was given to the physician who inquired about the treatment of axillary breast tissue in a teenage girl (1982;247:2301-2302). I believe the answer given shows a complete lack of understanding and/or empathy and typifies the depersonalization of medicine often, seen today. Axillary breast tissue is an embarrassment to the girl who has it. It limits her selection of clothes and her activity. The consultant suggested severe dietary restrictions. If you limit the clothing, activity, and food of a teenage girl, you have essentially deprived her of all facets of her social activities. The treatment is to remove this extraneous breast tissue. This can be done through relatively inconspicuous axillary incisions under general or local anesthesia. There is an excellent discussion of this problem and its treatment available.<sup>1</sup>
ANTISYPHILITIC TREATMENT OF SYPHILIS OF THE CENTRAL NERVOUS SYSTEM
Authors: HANS H. REESE
Journal: JAMA (1930)

The treatment of syphilis of the central nervous system belongs to the everyday practice of the neuropsychiatrist. In this paper I shall give the experiences and results obtained with combined antisyphilitic treatment in the Wisconsin Psychiatric Institute at the University of Wisconsin. An analysis of the enormous literature dealing critically with clinical, serologic and research problems of neurosyphilis shows that there are few diseases more diversely treated and that the trend of syphilotherapy is unfortunately toward simplification, which is to be deplored. It is not known whether the antisyphilitic agents now in use are spirocheticidal or whether they primarily change the lipoid metabolism by an omnicellular hyperactivity with unknown colloidal changes by which the bodily resistance becomes increased and the activity of the spirochetes becomes reduced. Nearly all investigators agree that malarial inoculation is the treatment of choice for arsenical-resistant cases of neurosyphilis, especially in paresis. It is felt that,
A Versatile and Scalable Two-Step Ion-Exchange Chromatography Process for the Purification of Recombinant Adeno-associated Virus Serotypes-2 and -5
Authors: Nicole Brument, Robert Morenweiser, Véronique Blouin, Estelle Toublanc, Isabelle Raimbaud, Yan Chérel, Sébastien Folliot, Florence Gaden, Pierre Boulanger, Gabrielle Kroner-Lux, Philippe Moullier, Fabienne Rolling, Anna Salvetti
Journal: Molecular Therapy (2002)

Here we describe the development of a two-step chromatography process based on the use of ion-exchange resins for the purification of recombinant adeno-associated virus (rAAV) serotypes-2 and -5. In vitro and in vivo results demonstrate that this method, which does not require any prepurification step of the cell lysate, can be applied to obtain highly pure rAAV2 and rAAV5 stocks. As such, this procedure can be easily transferred in vector cores and also scaled up, allowing the direct comparison of these two, and potentially other, AAV serotypes in large animal models.
Zfp423 Expression Identifies Committed Preadipocytes and Localizes to Adipose Endothelial and Perivascular Cells
Authors: Rana K. Gupta, Rina J. Mepani, Sandra Kleiner, James C. Lo, Melin J. Khandekar, Paul Cohen, Andrea Frontini, Diti Chatterjee Bhowmick, Li Ye, Saverio Cinti, Bruce M. Spiegelman
Journal: Cell Metabolism (2012)
IFN-γ suspends the killing license of anti-tumor CTLs
Authors: Aron E. Lukacher
Journal: Journal of Clinical Investigation (2002)

The magnitude and diversity of T cell responses reflects the outcome of a competition between positive signals initiated by T cell receptors (TCRs) and negative signals originating from an array of cell surface receptors. Fine control of this balance is essential for mobilizing protective immune responses while concurrently limiting potential immunopathologic complications, such as autoimmunity and destruction of bystander cells by toxic cytokines or cytolysis.