tbuckley/cabot-search huggingface dataset:
A NEW RADIUM APPLICATOR FOR CARCINOMA OF THE CERVIX
Authors: Harold Swanberg
Journal: JAMA (1928)

The adaptation of the French methods of administering radium in carcinoma of the cervix by an increasing number of American radium therapeutists is quite evident. The French school, led by Regaud of Paris (the associate of Mme. Curie), uses comparatively small amounts of radium over a long period of time, from heavily filtered, multiple centers.<sup>1</sup>This is accomplished by three sets of applicators—one that fits in the uterine canal, one that fits against the cervix, and another, called a "colpostat," that is fitted into the lateral vaginal fornices. I have attempted to simplify this technic by combining the first two mentioned applicators; thereby using two instead of three. This has been accomplished by a modification of the John G. Clark cervical applicator used in treating carcinoma of the cervix.<sup>2</sup>The Clark applicator is a T shaped applicator composed of 1 mm. of brass throughout, and covered with 0.5 mm. of aluminum. With this device, radium is introduced
GFI1 and GFI1B control the loss of endothelial identity of hemogenic endothelium during hematopoietic commitment
Authors: Christophe Lancrin, Milena Mazan, Monika Stefanska, Rahima Patel, Monika Lichtinger, Guilherme Costa, Özge Vargel, Nicola K. Wilson, Tarik Möröy, Constanze Bonifer, Berthold Göttgens, Valerie Kouskoff, Georges Lacaud
Journal: Blood (2012)
Respiratory system impedance from 4 to 40 Hz in paralyzed intubated infants with respiratory disease.
Authors: H L Dorkin, A R Stark, J W Werthammer, D J Strieder, J J Fredberg, I D Frantz
Journal: Journal of Clinical Investigation (1983)

To describe the mechanical characteristics of the respiratory system in intubated neonates with respiratory disease, we measured impedance and resistance in six paralyzed intubated infants with respiratory distress syndrome, three of whom also had pulmonary interstitial emphysema. We subtracted the effects of the endotracheal tube after showing that such subtraction was valid. Oscillatory flow was generated from 4 to 40 Hz by a loudspeaker, airway pressure was measured, and flow was calculated from pressure changes in an airtight enclosure mounted behind the flow source (speaker plethysmograph). After subtraction of the endotracheal tube contribution, resistance ranged from 22 to 34 cmH2O liter-1 s; compliance from 0.22 to 0.68 ml/cmH2O; and inertance from 0.0056 to 0.047 cmH2O liter-1 s2. Our results indicate that, for these intubated infants, the mechanics of the respiratory system are well described as resistance, compliance, and inertance in series. Most of the inertance, some of the resistance, and little of the compliance are due to the endotracheal tube. When the contribution of the endotracheal tube is subtracted, the results are descriptive of the subglottal respiratory system. These data characterize the neonatal respiratory system of infants with respiratory distress syndrome (with or without pulmonary interstitial emphysema) in the range of frequencies used during high frequency ventilation.
Antihyperglycemic Effect of Oolong Tea in Type 2 Diabetes
Authors: Kazuaki Hosoda, Ming-Fu Wang, Mei-Ling Liao, Chin-Kuang Chuang, Miyuki Iha, Beverly Clevidence, Shigeru Yamamoto
Journal: Diabetes Care (2003)

OBJECTIVE—To determine the efficacy of oolong tea for lowering plasma glucose in type 2 diabetic patients in Miaoli, Taiwan. RESEARCH DESIGN AND METHODS—A total of 20 free-living subjects who had type 2 diabetes and took hyperglycemic drugs as prescribed were enrolled in the present study. Subjects consumed oolong tea (1,500 ml) or water for 30 days each in a randomized crossover design. Tea was not consumed for 14 days prior to treatments. RESULTS—Relative to initial concentrations, oolong tea markedly lowered concentrations of plasma glucose (from 229 ± 53.9 to 162.2 ± 29.7 mg/dl, P &amp;lt; 0.001) and fructosamine (from 409.9 ± 96.1 to 323.3 ± 56.4 μmol/l, P &amp;lt; 0.01), whereas the water control group had not changed (208.7 ± 61.0 vs. 232.3 ± 63.1 mg/dl for glucose and from 368.4 ± 85.0 to 340.0 ± 76.1 μmol/l for fructosamine). CONCLUSIONS—Oolong tea may be an effective adjunct to oral hypoglycemic agents in the treatment of type 2 diabetes.
Circulating Endothelial Progenitors — Cells as Biomarkers
Authors: Anthony Rosenzweig
Journal: New England Journal of Medicine (2005)

Endothelial injury and dysfunction are thought to be critical events in the pathogenesis of atherosclerosis. Thus, understanding the mechanisms that maintain and restore endothelial function may have important clinical implications. A series of clinical and basic studies prompted by the discovery of bone marrow–derived endothelial progenitor cells1 have provided insights into these processes and opened a door to the development of new therapeutic approaches.Growing evidence suggests that bone marrow–derived endothelial progenitor cells circulate in the blood and play an important role in the formation of new blood vessels as well as contribute to vascular homeostasis in the adult. Circulating . . .
The effect of dexamethasone, cyclosporine, and rapamycin on T-lymphocyte proliferation in vitro: Comparison of cells from patients with glucocorticoid-sensitive and glucocorticoid-resistant chronic asthma
Authors: Angela Haczku, Andrew Alexander, Peter Brown, Basil Assoufi, Baiqing Li, A.Barry Kay, Christopher Corrigan
Journal: Journal of Allergy and Clinical Immunology (1994)
Healing of psoriatic skin lesions, and improvement of psoriatic arthritis resistant to immunosuppressive drugs, after infliximab treatment
Authors: S N Nikas, P V Voulgari, I P Takalou, P Katsimbri, A A Drosos
Journal: Annals of the Rheumatic Diseases (2005)

hydrocephalus (fig 1).Because of the hydrocephalus, it was neurologically advisable not to perform a cerebrospinal fluid puncture.There was no indication of tuberculosis (chest x ray examination, tuberculin test, sputum culture) or any other infection.The neoplasia investigation was also negative.An anamnestic investigation showed that there was no need to use ibuprofen or sulindac.When the situation became life threatening we initiated immunosuppressive treatment with cyclophosphamide (100 mg/day), as well as intravenous steroids (100 mg) initially.The initial intravenous cortisone treatment relieved the headache symptoms.Follow up examinations for up to 1 year (every 3 months) showed remission of clinical and MRI findings with this treatment (fig 2).Stable partial remission occurred after 8 months, and oral administration of cyclophosphamide was stopped.Treatment to preserve remission was changed to azathioprine (100 mg).The prednisone dose was finally reduced to 5 mg.
Highlights of the 2009 Scientific Sessions of the European Society of Cardiology
Authors: Jeroen J. Bax, Barbara Casadei, Carlo Di Mario, Robert Fagard, Gerasimos Filippatos, Keith A.A. Fox, Marco Metra, Petros Nihoyannopoulos, Joep Perk, Frank Rademakers, Raphael Rosenhek, Panos E. Vardas, Fausto J. Pinto, Roberto Ferrari
Journal: Journal of the American College of Cardiology (2009)
Acquired symmetrical dermal melanocytosis (naevus of Hori) developing after aggravated atopic dermatitis
Authors: F. Murakami, Y. Soma, M. Mizoguchi
Journal: British Journal of Dermatology (2005)

Summary Background Acquired symmetrical dermal melanocytosis (ASDM) is a pigmentary disorder characterized by blue–brown macules most frequently seen on the face of young and middle-aged Asian women. ASDM developing after other skin diseases has not been previously reported. Objectives To characterize the clinical and histopathological features of ASDM associated with atopic dermatitis (AD) and to elucidate the differences between AD-associated ASDM and idiopathic ASDM. Methods Sixteen patients with ASDM associated with AD were examined clinically and histopathologically and were compared with 69 patients with idiopathic ASDM. Results The AD patients associated with ASDM consisted of four men and 12 women with a mean age of 32·8 ± 13·1 years. Most patients remembered that the pigmented macules appeared in places where refractory eczema had existed for a long time. The marked preponderance in females and the appearance in the early reproductive period were common features of AD-associated ASDM and idiopathic ASDM. AD-associated ASDM was most commonly observed on the forehead (68·8%) and on the backs of the hands (50·0%), whereas 89·9% of idiopathic ASDM was seen on the cheeks. There was no significant difference in the number of dermal melanocytes between AD-associated ASDM and idiopathic ASDM. Electron microscopic studies demonstrated many mature melanocytes and smaller numbers of immature melanocytes in the dermis. Some melanocytes were seen adjacent to mast cells. Conclusions AD-associated ASDM does not appear to be rare in Japan. ASDM may be triggered in AD patients by sunlight exposure, some alterations in sex hormones and/or persistent cutaneous inflammation. Histamine and stem cell factor produced by mast cells may play crucial roles in the pathogenesis of AD-associated ASDM.
Detection of genomic- and minus-strand of hepatitis C virus RNA in the liver of chronic hepatitis C patients by strand-specific semiquantitative reversetranscriptase polymerase chain reaction
Authors: Francesco Negro, Krzysztof Krawczynski, Rafael Quadri, Laura Rubbia-Brandt, Mario Mondelli, Jean-Pierre Zarski, Antoine Hadengue
Journal: Hepatology (1999)

Studies aimed at correlating the intrahepatic hepatitis C virus (HCV)–RNA level and anatomo–clinical features have been difficult because of sensitivity and specificity shortcomings of available techniques. We titered the genomic– and minus–strand HCV RNAs by a strand–specific, semiquantitative, genotype–independent reverse–transcriptase polymerase chain reaction (RT–PCR) in the liver tissue of 61 patients with chronic hepatitis C. Findings were correlated with the levels of HCV RNA in the serum, the HCV genotype, the expression of intrahepatic HCV antigens, the histological activity (using separate scores for the lobular and the portal/periportal necroinflammatory activity and for the fibrosis), and the response to interferon alfa (IFN–α) treatment. Genomic– and minus–strand HCV RNA were detected in 59 and 57 liver specimens, respectively. The HCV–RNA level in the serum correlated with the genomic–strand, but not with the minus–strand, HCV–RNA titer in the liver. No correlations were found between either strand of the intrahepatic HCV RNA and the level of expression of HCV antigens in the liver, or with the grading/staging of the underlying liver disease. The response to IFN–α treatment could be predicted by the serum HCV–RNA level and genotype, but not by the intrahepatic level of genomic– or minus–strand HCV RNA. These results suggest that, although the detection of the minus–strand HCV RNA reliably identifies the presence of replicating HCV in its target organ, the quantitative measurement of viremia remains the clinically meaningful “golden standard” for assessing the level of HCV replication
Management of Head and Neck Cancer: A Multidisciplinary Approach
Authors: Walter G. Gunn
Journal: JAMA (1995)

It is now getting on for ten years since the first edition of this excellent work appeared. That effort broke new ground in several ways, chief of which was the extended collaboration of two experts in the fields of radiation oncology and surgery to document their long experience in working with head and neck cancer patients. In the tight anatomic compartments of the head and neck a variety of cancers originate and metastasize regionally. In this field a very close collaboration between radiation oncologist and surgeon is essential for patients to have the best chance for cure or extended palliation. All too often, however, that dictum of close collaboration is honored only in the breach. Not so with Million and Cassisi's book. The first edition showed their mutual efforts in every chapter: what to do with different sizes of tumors in the various compartments (T staging), how to manage the
New Revelations about the Long-QT Syndrome
Authors: J A Towbin
Journal: New England Journal of Medicine (1995)

Sudden death, a devastating event for any family, strikes more than 300,000 Americans each year. Cardiac arrhythmias, particularly ventricular arrhythmias, are thought to account for about 11 percent of all sudden deaths. In some cases there appears to be a familial propensity for sudden death. One inherited condition, the Romano–Ward long-QT syndrome, is an autosomal dominant disorder of cardiac repolarization that results in ventricular arrhythmias and sudden death. The long-QT syndrome has been thought to arise from either an abnormality of ion-channel regulation (the myocellular hypothesis) or altered activity of the autonomic nervous system, but definitive proof of either hypothesis . . .
FOXP3 Forkhead Domain Mutation and Regulatory T Cells in the IPEX Syndrome
Authors: Eva d'Hennezel, Moshe Ben-Shoshan, Hans D Ochs, Troy R Torgerson, Laura J Russell, Christine Lejtenyi, Francisco J Noya, Nada Jabado, Bruce Mazer, Ciriaco A Piccirillo
Journal: New England Journal of Medicine (2009)

To the Editor: The immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome, a rare disorder characterized by multiorgan autoimmunity, often results in death in infancy.1 The IPEX syndrome results from mutations in the forkhead box P3 (FOXP3) gene, which encodes a transcriptional repressor considered to be the master regulator of differentiation in CD4+ regulatory T (Treg) cells.2,3 Multiple FOXP3 mutations resulting in a range of clinical outcomes have been characterized.1–3 Since neither genetic sequencing nor protein expression correlates reliably with clinical manifestations in the IPEX syndrome,4 identification of the functional consequences of individual mutations is critical to . . .
Elamin Elnour (“Amin”) Osman
Authors: Kamil Sidahmed
Journal: BMJ (2005)

Former consultant in old age psychiatry United Lincolnshire NHS Trust (b 1943; q Simferopol, Ukraine, 1972), died from heart disease on 14 April 2005.

Amin was born in Omdurman, Sudan, and qualified in medicine at the Crimea Medical Institute, Simferopol, in the former Soviet Union. He practised in Sudan from 1972 to 1975. He arrived in Britain and worked in Bolton, Stockport, and Worcester before coming to Lincoln in 1983. Amin was a founder member of the Sudanese Medical Association of the United Kingdom. He leaves a wife, Naeema; and three children.
Generic Health Measurement: Past Accomplishments and a Measurement Paradigm for the 21st Century
Authors: Colleen A. McHorney
Journal: Annals of Internal Medicine (1997)

Generic health surveys have been proposed for use in increasingly diverse applications and populations. This paper describes the history of generic tools in the past 30 years and suggests a more modern measurement platform for advances in the 21st century. Many generic tools lack the precision required for effective health care decision making. A meaningful goal for the next era of development of generic measures should be the generation of equiprecise measurement for generic health concepts. Equiprecise tests yield measures of equal precision at all levels of the underlying construct. Equiprecise measurement can be achieved through conjoint use of computerized-adaptive testing as the survey platform and item response theory as the measurement theory.
Ribp, a Novel Rlk/Txk- and Itk-Binding Adaptor Protein That Regulates T Cell Activation
Authors: Keshava Rajagopal, Connie L. Sommers, Donna C. Decker, Elizabeth O. Mitchell, Ulf Korthauer, Anne I. Sperling, Christine A. Kozak, Paul E. Love, Jeffrey A. Bluestone
Journal: The Journal of Experimental Medicine (1999)

A novel T cell–specific adaptor protein, RIBP, was identified based on its ability to bind Rlk/Txk in a yeast two-hybrid screen of a mouse T cell lymphoma library. RIBP was also found to interact with a related member of the Tec family of tyrosine kinases, Itk. Expression of RIBP is restricted to T and natural killer cells and is upregulated substantially after T cell activation. RIBP-disrupted knockout mice displayed apparently normal T cell development. However, proliferation of RIBP-deficient T cells in response to T cell receptor (TCR)-mediated activation was significantly impaired. Furthermore, these activated T cells were defective in the production of interleukin (IL)-2 and interferon γ, but not IL-4. These data suggest that RIBP plays an important role in TCR-mediated signal transduction pathways and that its binding to Itk and Rlk/Txk may regulate T cell differentiation.
Coordinate regulation of glucose transporter function, number, and gene expression by insulin and sulfonylureas in L6 rat skeletal muscle cells.
Authors: P H Wang, D Moller, J S Flier, R C Nayak, R J Smith
Journal: Journal of Clinical Investigation (1989)

The extrapancreatic actions of sulfonylureas on the glucose transport system were studied in the L6 line of cultured rat skeletal muscle cells. Insulin (10(-7) M) increased 2-deoxyglucose uptake in differentiated L6 myotubes by 30-40% after 8 h of incubation. The sulfonylurea tolazamide (0.6 mg/ml, 22 h) had no effect on glucose uptake in the absence of insulin, but increased insulin-stimulated 2-deoxyglucose uptake twofold. The total cellular content of glucose transporters was assessed with a monoclonal anti-transporter antibody by a solid-phase ELISA method. Insulin (8 h) increased the quantity of glucose transporters, with a maximal twofold increase at 10(-7) M and a dose-response curve similar to that for insulin stimulation of glucose uptake. In spite of its lack of effect on glucose uptake, tolazamide alone (0.6 mg/ml) increased the cellular content of transporters by 70%. The effects of insulin and tolazamide on transporter gene expression were studied with probes derived from Hep G2 glucose transporter cDNA. Insulin increased the transporter mRNA level 1.7-fold, tolazamide increased it 1.5-fold, and the combination of insulin and tolazamide increased transporter mRNA 3-fold. It is concluded that sulfonylureas, together with insulin, enhance glucose uptake in L6 skeletal muscle cells by increasing the number of functioning glucose transport molecules. The long-term regulation of the glucose transport system in skeletal muscle by insulin and sulfonylureas in vivo may involve similar changes in transporter function, number, and gene expression.
Better Housestaff Schedules
Authors: Brent Brown
Journal: Annals of Internal Medicine (1989)

Letters and Corrections1 February 1989Better Housestaff SchedulesBrent Brown, MD, Robert Whang, MDBrent Brown, MDSearch for more papers by this author, Robert Whang, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-110-3-247 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor:I am writing in response to an article by the Association of Program Directors in Internal Medicine (1) on the stresses encountered by physicians during residency training. Some have implicated long hours as a cause of depression and stressful family relations, and believe that these schedules have deleterious effects on patient care (2). Various public figures, state legislatures, housestaff unions, and physician-educators have recommended reducing the hours of housestaff (3). Some internists have raised concerns that many medical students are entering lucrative specialties with flexible hours in preference to careers in internal medicine (4). The perceived rigors...References1. Stress and impairment during residency training: strategies for reduction, identification, and management. Ann Intern Med. 1988;109:154-61. LinkGoogle Scholar2. McCue J. The distress of internship. N Engl J Med. 1985;312:449-52. CrossrefMedlineGoogle Scholar3. McCall T. The impact of long working hours on resident physicians. N Engl J Med. 1988;318:775-8. CrossrefMedlineGoogle Scholar4. SchroederShowstackGerbert SJB. Residency training in internal medicine: time for a change? Ann Intern Med. 1986;104:554-6. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Oklahoma City Veterans Administration Medical Center University of Oklahoma College of Medicine Oklahoma City, OK 73104 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByMeasuring the Attitudes and Impact of the Eighty- Hour Workweek Rules on Orthopaedic Surgery ResidentsMeasuring the Attitudes and Impact of the Eighty-Hour Workweek Rules on Orthopaedic Surgery ResidentsThe Resident 80-Hour Work Week: How Has It Affected Surgical Specialties?Quality of prescribing of intravenous antibiotics in a district general hospital. 1 February 1989Volume 110, Issue 3Page: 247-248KeywordsPatientsResidency Issue Published: 1 February 1989 PDF DownloadLoading ...
Monitoring of adenovirus load in stool by real-time PCR permits early detection of impending invasive infection in patients after allogeneic stem cell transplantation
Authors: T Lion, K Kosulin, C Landlinger, M Rauch, S Preuner, D Jugovic, U Pötschger, A Lawitschka, C Peters, G Fritsch, S Matthes-Martin
Journal: Leukemia (2010)
An Account of a Demonstration on the Phenomena of Hystero-Epilepsy Given by Professor Charcot: And on the Modification which they Undergo under the Influence of Magnets and Solenoids
Authors: A. Gamgee
Journal: BMJ (1878)

met in Professor Charcot's wards in the great hospital of La Salpetriere, and had the privilege of being present at a demonstration in which this distinguished physician brought under their notice all the remarkable features of hystero-epilepsy-that remarkable disease almost all our knowledge of which is due to the labours of M. Charcot.In these demonstrations, the remarkable influence of solenoids and of magnets upon the diseased organism was exhibited, no less than the ready induction of the so-called mesmweric and cataleptic conditions in these patients.All the phases of the remarkable hystero-epileptic convulsions were repeatedly observed.Such was the interest awakened by these remarkable demonstrations, that I have willingly complied with the request of the editor of the BRITISH MEDICAL JOURNAL-who was himself an interested spec.tator-to give an account of the principal facts which were brought under our notice on the occasion of the second demonstration.In order that the description of these facts may be the more intel- ligible to those who are unacquainted with even the salient points in the natural history of hystero-epilepsy, I will summarise these briefly, as follows.Hystero-epilepsy is a nervous disease of women of great rarity, affecting them especially during the child-bearing period of life; sometimes, though rarely, occurring before the actual commence- ment of menstruation, and continuing after its cessation.It is asso-