T-Cell Lymphoma, Tropical Spastic Paraparesis, and Malignant Fibrous Histiocytoma in a Patient with Human T-Cell Lymphotropic Virus, Type 1
Authors: James W. Lee
Journal: Annals of Internal Medicine (1989)

Brief Reports1 February 1989T-Cell Lymphoma, Tropical Spastic Paraparesis, and Malignant Fibrous Histiocytoma in a Patient with Human T-Cell Lymphotropic Virus, Type 1James W. Lee, MD, Edward P. Fox, MD, Pamela Rodgers-Johnson, MD, Clarence J. Gibbs Jr, PhD, Elaine DeFreitas, PhD, Angela Manns, MD, MPH, William Blattner, MD, James Cotelingam, MD, Pedro Piccardo, MD, Carlos Mora, MD, Jiri Safar, MD, Pawel Liberski, MD, Edward Sausville, MD, PhD, Jane Trepel, MD, Barnett S. Kramer, MDJames W. Lee, MDSearch for more papers by this author, Edward P. Fox, MDSearch for more papers by this author, Pamela Rodgers-Johnson, MDSearch for more papers by this author, Clarence J. Gibbs Jr, PhDSearch for more papers by this author, Elaine DeFreitas, PhDSearch for more papers by this author, Angela Manns, MD, MPHSearch for more papers by this author, William Blattner, MDSearch for more papers by this author, James Cotelingam, MDSearch for more papers by this author, Pedro Piccardo, MDSearch for more papers by this author, Carlos Mora, MDSearch for more papers by this author, Jiri Safar, MDSearch for more papers by this author, Pawel Liberski, MDSearch for more papers by this author, Edward Sausville, MD, PhDSearch for more papers by this author, Jane Trepel, MDSearch for more papers by this author, Barnett S. Kramer, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-110-3-239 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHuman T-cell lymphotropic virus, type 1 (HTLV-1), is the causative agent of both the acute and smoldering forms of adult T-cell leukemia-lymphoma, as shown by isolation of the virus from the leukemia cells and a rate of more than 90% antibody seropositivity for HTLV-1 in these patients (1-3). Mycosis fungoides is another HTLV-1-associated T-cell lymphoma, although seropositivity occurs in only 11% to 15% of patients (4). The virus is also associated with tropical spastic paraparesis and HTLV-1-associated myelopathy, identical chronic myeloneuropathies characterized by insidious spastic paraparesis and evidence of systemic and central nervous system HTLV-1 infection (5, 6).Transgenic mice...References1. MitsuyaMatisMegson HLM. Generation of an HLA-restricted cytotoxic T cell line reactive against cultured tumor cells from a patient infected with human T cell leukemia/lymphoma virus. J Exp Med. 1983;158:994-9. CrossrefMedlineGoogle Scholar2. BlattnerBiggarWeissClarkGoedert WRSJJ. Epidemiology of human lymphotropic retroviruses: an overview. Cancer Res. 1985;45(Suppl):4598S-601S. MedlineGoogle Scholar3. TakatsukiYamaguchiKawano KKF. Clinical diversity in adult T-cell leukemia-lymphoma. Cancer Res. 1985;45(Suppl):4644S-5S. MedlineGoogle Scholar4. WantzinThomsenNissenSaxingerGallo GKNCR. Occurrence of human T cell lymphotropic virus (type 1) antibodies in cutaneous T cell lymphoma. J Am Acad Dermatol. 1986:15:598-602. CrossrefMedlineGoogle Scholar5. OsameMatsumotoUsuku MMK. Chronic progressive myelopathy associated with elevated antibodies to human T-lymphotropic virus type 1 and adult T-cell leukemialike cells. Ann Neurol. 1987;21:117-22. CrossrefMedlineGoogle Scholar6. VernantMaursGessain JLA. Endemic tropical spastic paraparesis associated with human T-lymphotropic virus type I: a clinical and seroepidemiological study of 25 cases. Ann Neurol. 1987;21:123-30. CrossrefMedlineGoogle Scholar7. NerenbergHinrichsReynoldsKhouryJay MSRGG. The tat gene of human T-lymphotropic virus type 1 induces mesenchymal tumors in transgenic mice. Science. 1987;237:1324-9. CrossrefMedlineGoogle Scholar8. HinrichsNerenbergReynoldsKhouryJay SMRGG. A transgenic model for human neurofibromatosis. Science. 1987;237:1340-3. CrossrefMedlineGoogle Scholar9. WaldmannGreeneSarin TWP. Functional and phenotypic comparison of human T cell leukemia/lymphoma virus positive adult T cell leukemia with human T cell leukemia/lymphoma virus negative Sezary leukemia, and their distinction using anti-Tac. Monoclonal antibody identifying the human receptor for T cell growth factor. J Clin Invest. 1984;73:1711-8. CrossrefMedlineGoogle Scholar10. GibbsLoftersCampbell WWM. Non-Hodgkin lymphoma in Jamaica and its relation to adult T-cell leukemia-lymphoma. Ann Intern Med. 1987;106:361-8. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From the National Cancer Institute, Naval Hospital Bethesda, National Institute of Neurological and Communicative Disorders and Stroke, the Uniformed Services University of the Health Sciences, Bethesda, Maryland; and the Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania. For current author addresses, see end of text. 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