Effect of Dextro-isomers of Thyroid Hormones on Serum Cholesterol Levels in Euthyroid Hypercholesterolemic Patients
Authors: LEO E. HOLLISTER
Journal: Annals of Internal Medicine (1962)

Article1 April 1962Effect of Dextro-isomers of Thyroid Hormones on Serum Cholesterol Levels in Euthyroid Hypercholesterolemic PatientsLEO E. HOLLISTER, M.D., F.A.C.P., WALTER L. ARONS, M.D.LEO E. HOLLISTER, M.D., F.A.C.P.Search for more papers by this author, WALTER L. ARONS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-56-4-570 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough evidence is still largely circumstantial, elevated serum lipid levels seem to be related to the development of atherosclerosis and its complications (1). When the physician is confronted with a patient showing an elevated serum cholesterol, he usually feels obliged to attempt treatment with the idea either of preventing atherosclerotic complications, or if they have already occurred, of reducing their progress.For a number of years, thyroid hormones have been known to reduce serum cholesterol levels in euthyroid as well as hypothyroid patients (2, 3). Hypermetabolic effects from these hormones, potentially dangerous for patients with compromised myocardial or systemic circulations,...References1. LOWNSTARE BF: Editorial. Atherosclerosis, infarction and nutrition. Circulation 20: 161, 1959. CrossrefMedlineGoogle Scholar2. STRISOWERELMLINGERGOFMANDELALLA BFJWO: The effect of 1-thyroxine on serum lipoprotein and cholesterol concentrations. J. Clin. Endocr. 19: 117, 1959. CrossrefGoogle Scholar3. SACHSDANIELSONISAACWESTON BAEMCRE: Effect of triiodothyronine on the serum lipids and lipoproteins of euthyroid and hyperthyroid subjects. J. Clin. Endocr. 18: 506, 1958. CrossrefGoogle Scholar4. RAWSONMONEYKROCKUMAOKABENUA RWWLRLSRS: A dissociation of thyroid hormonal effects by structural alterations of the thyroxine molecule. Amer. J. Med. Sci. 283: 261, 1959. CrossrefGoogle Scholar5. KRAMERORVISTHOMAS NCNWR: Clinical and metabolic effects of d-triiodothyronine therapy in angina patients. Clin. Res. 9: 183, 1961. Google Scholar6. STARR P: The therapeutic value of sodium dextrothyroxine. Clin. Pharmacol. Ther. 1: 716, 1960. Google Scholar7. STARR P: Sodium dextrothyroxine and sodium levothyroxine. J. A. M. A. 173: 1934, 1960. CrossrefMedlineGoogle Scholar8. STARRROENFREIBRUMSCHLEISSNER PPJLLA: Reduction of serum cholesterol by sodium dextrothyroxine. Arch. Intern. Med. 105: 830, 1960. CrossrefMedlineGoogle Scholar9. ALBRINKMEIGSMAN MJJWEB: Serum lipids, hypertension and coronary artery disease. Amer. J. Med. 31: 4, 1961. CrossrefMedlineGoogle Scholar10. KRITCHEVSKY D: Influence of thyroid hormones and related compounds on cholesterol biosynthesis and degradation: a review. Metabolism 9: 984, 1960. MedlineGoogle Scholar11. HOOBLERCOLWELLBEIERWALTES SWCWWH: D-thyroxine in the treatment of hypercholesterolemia. J. Mich. Med. Soc, 59: 1704, 1960. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Palo Alto, CaliforniaPresented in part at The Forty-second Annual Meeting of the American College of Physicians, Miami Beach, Florida, May 8-12, 1961.Requests for reprints should be addressed to Leo E. Hollister, M.D., Veterans Administration Hospital, 3801 Junipero Serra Boulevard, Palo Alto, California. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLDL-R promoting activity of peptides derived from human PCSK9 catalytic domain (153–421): Design, synthesis and biochemical evaluationNovel therapeutic agents for lowering low density lipoprotein cholesterol4 Antihyperlipidaemic AgentsStudy of the lipid-lowering action of choloxin and Nilevar in patients with chronic renal failureCholesterol-lowering effect of dextro-thyroxine in patients with hypercholesterolemia and coronary diseaselThe status of hormonal therapy for the primary and secondary prevention of atherosclerotic coronary heart diseaseDextro-Thyroxine as a Cholesterol-Lowering Agent in Patients with Angina Pectoris 1 April 1962Volume 56, Issue 4Page: 570-576KeywordsAtrial fibrillationCholesterolHormonesHypercholesterolemiaLesionsLipidsProteinsThrombosisThyroidThyroid hormones ePublished: 1 December 2008 Issue Published: 1 April 1962 PDF downloadLoading ...