Repeatedly False-Negative Rapid HIV Test Results in a Patient with Undiagnosed Advanced AIDS
Authors: Patricia Brown, Joseph R. Merline, Diane Levine, Lucio Román Minces
Journal: Annals of Internal Medicine (2008)

Letters1 July 2008Repeatedly False-Negative Rapid HIV Test Results in a Patient with Undiagnosed Advanced AIDSPatricia Brown, MD, Joseph R. Merline, PhD, Diane Levine, MD, and Lucio Román Minces, MDPatricia Brown, MDFrom Wayne State University, Detroit, MI 48201., Joseph R. Merline, PhDFrom Wayne State University, Detroit, MI 48201., Diane Levine, MDFrom Wayne State University, Detroit, MI 48201., and Lucio Román Minces, MDFrom Wayne State University, Detroit, MI 48201.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-149-1-200807010-00028 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Background: The OraQuick ADVANCE (OraSure Technologies, Bethlehem, Pennsylvania) is useful for point-of-care testing, particularly when patients are unlikely to return for their results. It has been reported to have diagnostic sensitivity and specificity similar to or higher than those of standard serologic testing when screening certain populations (1). However, OraQuick can yield false-negative results when used in patients receiving highly active antiretroviral therapy who have fluctuating levels of antibodies (2) and when used to screen asymptomatic patients with unknown HIV status (1, 3), particularly those with early HIV infection (4).Objective: To describe a patient with persistently false-negative rapid HIV ...References1. Delaney KP, Branson BM, Uniyal A, Kerndt PR, Keenan PA, Jafa K, et al. Performance of an oral fluid rapid HIV-1/2 test: experience from four CDC studies. AIDS. 2006;20:1655-60. [PMID: 16868447] CrossrefMedlineGoogle Scholar2. O'Connell RJ, Merritt TM, Malia JA, VanCott TC, Dolan MJ, Zahwa H, et al. Performance of the OraQuick rapid antibody test for diagnosis of human immunodeficiency virus type 1 infection in patients with various levels of exposure to highly active antiretroviral therapy. J Clin Microbiol. 2003;41:2153-5. [PMID: 12734265] CrossrefMedlineGoogle Scholar3. Bhore AV, Sastry J, Patke D, Gupte N, Bulakh PM, Lele S, et al. Sensitivity and specificity of rapid HIV testing of pregnant women in India. Int J STD AIDS. 2003;14:37-41. [PMID: 12590791] CrossrefMedlineGoogle Scholar4. Stekler J, Wood RW, Swenson PD, Golden M. Negative rapid HIV antibody testing during early HIV infection [Letter]. Ann Intern Med. 2007;147:147-8. [PMID: 17638724] LinkGoogle Scholar5. Ellenberger DL, Sullivan PS, Dorn J, Schable C, Spira TJ, Folks TM, et al. Viral and immunologic examination of human immunodeficiency virus type 1-infected, persistently seronegative persons. J Infect Dis. 1999;180:1033-42. [PMID: 10479128] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Wayne State University, Detroit, MI 48201.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoNegative Rapid HIV Antibody Testing during Early HIV Infection Joanne Stekler , Robert W. Wood , Paul D. Swenson , and Matthew Golden Metrics Cited ByEvaluation of the diagnostic performance and optimal cutoff value of a fourth-generation ELISA, VIDAS HIV-1/2 Duo Ultra assay, in a low-prevalence countryBacterial Dermatoses in HIV/AIDS PatientsUltra-rapid, sensitive and specific digital diagnosis of HIV with a dual-channel SAW biosensor in a pilot clinical studyp24 revisitedSelecting an HIV Test: A Narrative Review for Clinicians and Researchers2014 European Guideline on HIV testingFailure to Identify HIV-Infected Individuals in a Clinical Trial Using a Single HIV Rapid Test for ScreeningLong-term highly suppressed HIV-infected children and adolescents with negative rapid HIV tests due to significant antibody lossSeronegativation in Early Treated HIV-Infected Infants: Frequency and Potential Implications on Care and Follow-up in a Resource-Limited CountryEvaluation of the Performance Characteristics of 6 Rapid HIV Antibody TestsConcurrent Pneumocystis jiroveci Pneumonia and Cryptococcosis in a Man With False-Negative Oral Rapid Human Immunodeficiency Virus Test ResultsPerformance of OraQuick Advance® Rapid HIV-1/2 Antibody Test for detection of antibodies in oral fluid and serum/plasma in HIV-1+ subjects carrying different HIV-1 subtypes and recombinant variants2008 European Guideline on HIV testing 1 July 2008Volume 149, Issue 1Page: 71-72KeywordsAIDSAntibodiesEnzyme linked immunosorbent assayFeversHIVHIV infectionsHIV-1PatientsWeight lossWestern blot ePublished: 1 July 2008 Issue Published: 1 July 2008 CopyrightCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...