Allogeneic Bone Marrow Transplantation in Chronic Lymphocytic Leukemia
Authors: Issa Khouri
Journal: Annals of Internal Medicine (1996)

Letters1 November 1996Allogeneic Bone Marrow Transplantation in Chronic Lymphocytic LeukemiaIssa Khouri, MD and Richard Champlin, MDIssa Khouri, MDUniversity of Texas M.D. Anderson Cancer Center Houston, TX 77030.Search for more papers by this author and Richard Champlin, MDUniversity of Texas M.D. Anderson Cancer Center Houston, TX 77030.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-9-199611010-00026 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Michallet and colleagues [1] correctly assert that it is unknown how the results collected from the International Bone Marrow Transplant Registry and the European Group for Blood and Marrow Transplantation regarding allogeneic bone marrow transplantation for CLL compare with those of conventional therapies. To answer this question, we studied allogeneic bone marrow and stem-cell transplantation for patients with advanced CLL [2, 3] who failed to respond to fludarabine, an agent considered by many to be the most effective conventional treatment for CLL. These patients usually have a poor prognosis [4]. Sixteen patients had transplantation; 13 were refractory, ...References1. Michallet M, Archimbaud E, Bandini G, Rowlings PA, Deeg HJ, Gahrton G, et al. HLA-identical sibling bone marrow transplantation in younger patients with chronic lymphocytic leukemia. Ann Intern Med. 1996; 124:311-5. Google Scholar2. Khouri I, Keating MJ, Przepiorka D, van Besien K, Gajewski J, O'Brien S, et al. Stem cell transplantation (SCT) for chronic lymphocytic leukemia (CLL): graft-versus-leukemia (GVL) without acute graft-versus-host-disease [Abstract]. Blood. 1995; 10(Suppl 1):457a. Google Scholar3. Khouri I, Keating M, Vriesendorp HM, Reading CL, Przepiorka D, Hun YO, et al. Autologous and allogeneic bone marrow transplantation for chronic lymphocytic leukemia: preliminary results. J Clin Oncol. 1994; 12:748-58. Google Scholar4. Keating MJ, O'Brien S, Kantarjian M, Plunket W, Estey E, Koller C, et al. Long-term follow-up of patients with chronic lymphocytic leukemia treated with fludarabine as a single agent. Blood. 1993; 81:2878-84. Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Texas M.D. Anderson Cancer Center Houston, TX 77030. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTransplant in Chronic Lymphocytic Leukemia: To Do It or Not and If So, When and How?The Role of Stem-Cell Transplantation in Chronic Lymphocytic LeukemiaStem Cell Transplantation for Indolent Lymphoma and Chronic Lymphocytic LeukemiaStem cell transplantation in chronic lymphocytic leukaemia – steering a safe course over shifting sandsTransplantation in Chronic Lymphocytic Leukemia: Timing and ExpectationsChronic lymphocytic leukemiaStem Cell Transplantation in Chronic Lymphocytic LeukemiaStem Cell Transplantation in CLLIndolent Lymphomas Other than Follicular and Marginal Zone LymphomasStem-cell transplantation in chronic lympocytic leukaemiaTransplantation in chronic lymphocytic leukemiaSalvage Therapy for CLL and the Role of Stem Cell TransplantationInduction of chronic lymphocytic leukemia (CLL)–specific CD4- and CD8-mediated T-cell responses using RNA-transfected dendritic cells 1 November 1996Volume 125, Issue 9Page: 780KeywordsBloodBlood groupsBone marrowBone marrow transplantationChronic lymphocytic leukemiaFlow cytometryTransplantation Issue Published: 1 November 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...