tbuckley/cabot-search huggingface dataset:
The Perfect Arrangement
Authors: Sarah P. Blagden
Journal: Journal of Clinical Oncology (2014)

Mrs G. greeted the news that her cancer was progressing with resignation, a reaction that none of us could have predicted.I suppose she had always been a difficult patient to read.She was tall and dignified and, though in her sixties, still carried remnants of youthful good looks.As well as elegance, she had a cool demeanor.She elicited awe from me and the other members of a team accustomed to more communicative patients.She had a small, sensitivelooking husband and two children in their twenties who had inherited her looks along with a good measure of self-assuredness.Despite their air of confidence, they too appeared to be intimidated by their mother as she observed them, as if from a distance, as they fussed around her.For this admission, she had been given a side room on the ward, and on that day the consultant oncologist spoke to her in a hushed voice as if he were a schoolboy reporting to his headmistress.He explained that her endometrial cancer had grown rapidly despite treatment and that further chemotherapy was unlikely to be successful.She observed him dispassionately as he broke the news, her face displaying no trace of emotion.I returned to see her after the ward round.As a junior registrar I had grown fond of Mrs G.There was something in her chilliness that made me want to please her.I knocked nervously before entering her room.It was standard-issue in its drabness with its strip lighting and peeling blue paint on the walls.A curtain flapped in the open window and threatened to dislodge the few cards along its sill.She sat stiffly upright in bed, simultaneously disinterested and disengaged from her surroundings.I perched beside her, unsure whether she would take kindly to the assumed intimacy.There was a heavy silence that drowned the ambient ward noises outside.She turned her light blue gaze toward me."I deserve it," she said in a flat, distant voice.I tried to interject that this was not the case, but she closed her eyes and slowly and deliberately said "I brought this on myself.This cancer is my punishment."She caught my awkward expression and observed me critically as if weighing the wisdom of proceeding.Finally she said "A long time ago I met someone."His name was John, and he was 10 years her senior and a charismatic businessman.
Extraosseus Uptake with Bone Scintigraphy
Authors: SAULE KARANAUSKAS, ROBERT G. WELLS, JOHN R. STY
Journal: Clinical Nuclear Medicine (1991)

We report a case of mesenchymal chondrosarcoma of the kidney in a 15-year-old boy who presented with a palpable metastatic focus in the right axilla. Bone scintigraphy performed as part of the initial evaluation of this child showed intense uptake within the occult primary lesion in the right kidney, as well as metastases in the lungs and right axilla. Although rare, this entity should be included in the differential diagnosis of focal abnormal renal uptake of bone-seeking radiopharmaceuticals.
Chromium deficiency and cardiovascular risk
Authors: M. SIMONOFF
Journal: Cardiovascular Research (1984)

Recent measurements have demonstrated that plasma chromium levels in patients with coronary artery disease are very much lower than in normal subjects. A review of the literature concerning the physiological functions of chromium (or GTF) shows it to be implicated in most of the known factors of cardiovascular risk, via its effect on insulin levels and activities. Chromium deficiency leads to impaired lipid and glucide metabolism and results in high circulating insulin levels, the probable consequences of which suggest that chromium deficiency may be a primary risk factor in cardiovascular disease.
Eye Disease in Veterans With Diabetes
Authors: James Orcutt, Arpenik Avakian, Thomas D. Koepsell, Charles Maynard
Journal: Diabetes Care (2004)

To describe the screening, prevalence, and management of eye disease in veterans cared for by the Veterans Affairs (VA) System.Eye examinations, treatments, and diseases were identified in veterans with diabetes who received care in inpatient and outpatient VA settings during FY1998. Analysis was conducted to characterize the patient population and screened population and to compare them to the total VA patient population with diabetes. Logistic regression was performed to predict eye screening.Overall 48% of veterans with diabetes had an eye examination in FY1998. One-third of all veterans had an eye condition and 8.6% of veterans had ophthalmic manifestations of diabetes. In addition 11% reported glaucoma and 17.8% reported cataract surgery. Approximately 11,500 (2.7%) veterans were blind.Visual impairment is a common complication of diabetes. Half of this population of veterans had a visual examination recorded in VA. The VA is testing a more targeted screening and treatment approach for diabetic eye disease in order to prevent the serious eye complications.
Iodinated Contrast Media Hypersensitivity Diagnosis-Skin Tests and Limphoblastic Transformation Test
Authors: A.F.F. Ferrão, R.P. Reis, L.A. Patricio, M.R. Viseu, S.H. Correia, S.H. Correia, M.J. Peres, E.M. Tomaz, F.C. Inácio
Journal: Journal of Allergy and Clinical Immunology (2007)
Primary Intraluminal Aortic Myxoma With Involvement of Several Vertebrae
Authors: Odell C. Kimbrell
Journal: JAMA (1973)

To our knowledge, only five of the reported cases of primary aortic neoplasms have been primary intraluminal myxomas. The most frequent clinical manifestations have been an accelerating, often severe, hypertension, arterial occlusive findings, and a loud aortic bruit. In this case, several vertebral bodies were invaded by the tumor.
T-Type and Tetrodotoxin-Sensitive Ca <sup>2+</sup> Currents Coexist in Guinea Pig Ventricular Myocytes and Are Both Blocked by Mibefradil
Authors: Jürgen F. Heubach, Arndt Köhler, Erich Wettwer, Ursula Ravens
Journal: Circulation Research (2000)

Abstract —Under Na + -free conditions, low-voltage–activated Ca 2+ currents in cardiomyocytes from various species have been described either as Ni 2+ -sensitive T-type Ca 2+ current ( I Ca(T) ) or as tetrodotoxin (TTX)-sensitive Ca 2+ current ( I Ca(TTX) ). So far, coexistence of the 2 currents within the same type of myocyte has never been reported. We describe experimental conditions under which I Ca(T) and I Ca(TTX) can be separated and studied in the same cell. Rat and guinea pig ventricular myocytes were investigated with the whole-cell voltage-clamp technique in Na + -free solutions. Whereas rat myocytes lack I Ca(T) and exhibit I Ca(TTX) only, guinea pig myocytes possess both of these low-voltage–activated Ca 2+ currents, which are separated pharmacologically by superfusion with TTX or Ni 2+ . I Ca(T) and I Ca(TTX) were of similar amplitude but significantly differed in their electrophysiological properties: I Ca(TTX) activated at more negative potentials than did I Ca(T) , the potential for half-maximum steady-state inactivation was more negative, and current deactivation and recovery from inactivation were faster. I Ca(TTX) but not I Ca(T) increased after membrane rupture (“run-up”). Isolation of I Ca(TTX) by application of the bivalent cation Ni 2+ is critical because of possible shifts in voltage dependence. Therefore, we investigated whether the T-type Ca 2+ channel blocker mibefradil (10 μmol/L) is a suitable tool for the study of I Ca(TTX) . However, mibefradil not only blocked I Ca(T) by 85±2% but also decreased I Ca(TTX) by 48±8%. We conclude that under Na + -free conditions I Ca(T) and I Ca(TTX) coexist in guinea pig ventricular myocytes and that both currents are sensitive to mibefradil. Future investigations of I Ca(T) will have to consider the TTX-sensitive current component to avoid possible interference.
Removal of Moles, Warts and Other Benign Growths
Authors: O. I. Bemis
Journal: JAMA (1910)

given to it by Neumann is Ibis: It is a synonym of D. retícula- tus as interpreted by Neumann, namely, I), retioulatus of Kurope plus specimens examined by »Mar».I'roni Texas and New .Mexico, plus certain other forms.Two possibilities arc present: (1) If reallv identical with D. retioulatus, the name I), rentistas drops into synonymy and cannot he-used for the spotted-fever lick.(2) 'fhe only way of separating the inline from I), reticttlatiis is by finding the original specimens from Texas or New Mexico and showing that they are not identical with /*.retioulatus.In material recently at my disposal, I hud specimens of the Mars collection labeled Dermaoentor venustus from both Texas and New Mexico.These are the specimens on which Neumann published in 1897, and it is the Texas specimen from sheep which I designated as the type, 'fliese specimens nre clearly distinct from the European />.retioulatus, and they represent the form which I have published ¡is D. rennst us.Mr. Hanks was present at a meeting of the Entomological Society.Jan. 10, 1907, when I showed drawings of the European I), retioulatus, and explained the differences between this and the various American forms.He also visited my lab¬ oratory for the specific purpose of »examining Marx' material, and at Unit time the originals of I), venustus, I), oooidentalis and I), ant/ersoni were placed before him.together with draw¬ ings of the stignuil plates.lie later (1908) published "Dermaoentor venustus n. sp.," admitting that it was Marx'
Protein S abnormalities: A diagnostic nightmare
Authors: Richard A. Marlar, Jana N. Gausman
Journal: American Journal of Hematology (2011)

Heterozygous deficiency of Protein S (PS) increases the risk for developing thrombosis. Many acquired conditions alter plasma PS levels. These complex interactions of PS in plasma make it imperative that clinical PS assay limitations are understood so that the assays are reliable, reproducible and specific to diagnose true genetic abnormalities based on plasma phenotype alone. Unfortunately, the diagnosis of PS deficiency is difficult and complicated. Three basic assays can be utilized for assessing PS in plasma: PS activity assay, Free PS antigen assay, and Total PS antigen assay. This article will review these clinical assays and their associated problems. We also discuss the confounding and interfering factors that make it difficult to obtain an accurate diagnosis of PS deficiency.
Selective Estrogen Receptor Modulators and Prevention of Invasive Breast Cancer
Authors: William J. Gradishar, David Cella
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Asian doctors are still being discriminated against
Authors: A. Esmail, S. Everington
Journal: BMJ (1997)

Editor—Five years ago, when we published our research on the discrimination faced by ethnic minority doctors applying for posts as senior house officers,1 the Department of Health considered using our methodology to monitor progress in tackling discrimination. At a recent BMA conference to discuss racial discrimination in the medical profession several speakers pointed out that racial discrimination was still endemic in the NHS and that direct policy initiatives to tackle specific examples of discrimination–for example, in the shortlisting of job applications for hospital posts–were lacking.2 …
URTICARIA AND HAY-FEVER DUE TO TRICHOPHYTIN (EPIDERMOPHYTON INTERDIGITALE)
Authors: Fred Wise
Journal: JAMA (1930)

Recently one of us 1 together with Phyllis Kerr reported a case of urticarial hypersensitiveness to trichophytin, in which the passive transference by means of the blood serum (method of Prausnitz-Kustner) proved successful. To our knowledge this was the first case of its kind reported, and we called attention to the fact that the discovery of this type of hypersensitiveness made it possible that trichophytin products of pathogenic fungi might be the cause of some asthmas and hay-fevers, as well as of urticarias. In view of the widespread prevalence of ringworm infections, particularly those of the feet, it would seem to us to be reasonable to consider the possibility of an ever-present allergen in the investigation of patients with these disorders.  Since our first report, Ramirez, 2 in further expansion of our experiments, has discovered and published the report of a case of asthma which could be traced to trichophytin.
The Urticarias 1990
Authors: A. KOBZA BLACK, M.W. GREAVES, R.H. CHAMPION, R.J. PYE
Journal: British Journal of Dermatology (1991)

Journal Article The Urticarias 1990 Get access A. KOBZA BLACK, A. KOBZA BLACK Institute of Dermatology, St Thomas's Hospital, London Dr A. Kobza Black. Institute of Dermatology. St Thomas's Hospital, London SE1 7EH. Search for other works by this author on: Oxford Academic Google Scholar M.W. GREAVES, M.W. GREAVES Institute of Dermatology, St Thomas's Hospital, London Search for other works by this author on: Oxford Academic Google Scholar R.H. CHAMPION, R.H. CHAMPION Department of Dermatology, Addenbrooke's Hospital, Cambridge Search for other works by this author on: Oxford Academic Google Scholar R.J. PYE R.J. PYE Department of Dermatology, Addenbrooke's Hospital, Cambridge Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 124, Issue 1, 1 January 1991, Pages 100–108, https://doi.org/10.1111/j.1365-2133.1991.tb03292.x Published: 01 January 1991
Acquired Syphilis in a Patient With Congenital Syphilis
Authors: Nicholas J. Fiumara
Journal: JAMA (1965)

IT IS commonly acknowledged that patients treated for early acquired infectious syphilis can be reinfected on subsequent exposure to an infectious case. So well known is this that the phenomenon of reexposure with resultant reinfection has been picturesquely and facetiously called pingpong syphilis.  Immunity in untreated syphilis develops rather slowly, with time measured in weeks rather than days. Thus, it may be three months or so before any clinically detectable immunity occurs. As long as the patient remains untreated, the immunity status to superinfection continues. Once the patient is treated, however, immunity to reinfection is relative and depends upon the degree of immunity achieved prior to treatment and the interval of time between treatment and reexposure. With time, there is a slow decline in the immunity level of any treated patient.  The cure of early infectious syphilis with penicillin is so rapid that in 24 hours one cannot detect Treponema
Neuropathy After Intake of Thalidomide (Distaval)
Authors: P. M. Fullerton, M. Kremer
Journal: BMJ (1961)

BEDS Xso 855 hospitals in rural districts (and in some urban areas), in annexes or wards of general hospitals in large towns and cities.The hospital services are greatly helped, and the continuing education of general practitioners is advanced, when they work in wards or out-patient departments of larger hospitals as " clinical assistants " for not more than one or two sessions a week under the supervision of consultants.More of these appointments are needed.Senior and junior grades of clinical assistantships should be officially recognized and intro- duced into specialist teams with different rates of pay and differing degrees of responsibility.The senior grade should be long-term appointments, perhaps for several years, in which general practitioners with special interests and experience could play a really useful part in the work of hospitals, in a more important and responsible role than that of clinical assistants at present.The junior grade could be short-term appointments for those learning to develop special interests or striving to maintain their continuing education.These measures should go far towards closing any rifts " or " gaps," where they exist, between family doctors and consultants and between general practice and hospital work; and it should lead to better and much-needed integration, and happier co-operation, between these two great branches of our profession.
Misinterpretation of Footnote
Authors: Henry J. Heimlich
Journal: JAMA (1983)

To the Editor.—  A footnote (1980; 244:453) has sometimes been interpreted to indicate that the National Academy of Sciences-National Research Council (NAS-NRC) cosponsored the National Conference on Cardiopulmonary Resuscitation and Emergency Cardiac Care held by the American Heart Association in September 1979. This is incorrect (P. Handler, former president of NASNRC, written communication, 1979).
Abstract 2440: CD47 is a prognostic factor and an antibody target that synergizes with rituximab to eradicate non-Hodgkin lymphoma
Authors: Mark P. Chao, Ash A. Alizadeh, Chad Z. Tang, June H. Myklebust, Bindu Varghese, Max Jan, Adriel C. Cha, Brent T. Tan, Christopher Y. Park, Ronald Levy, Irving L. Weissman, Ravindra Majeti
Journal: Cancer Research (2010)

Abstract Monoclonal antibodies are standard therapeutics for several cancers including the anti-CD20 antibody rituximab for B cell non-Hodgkin lymphoma (NHL). Rituximab and other antibodies are not curative, and must be combined with cytotoxic chemotherapy for clinical benefit. Here we identify CD47 as an attractive monoclonal antibody target in NHL. A major function of CD47 is to inhibit phagocytosis, through binding its receptor, SIRP-alpha, on phagocytes. We hypothesize that NHL cells over-express CD47 to evade immune phagocytosis and that blockade of CD47 signaling by a monoclonal antibody can eliminate NHL cells by enabling phagocytic engulfment. Here we investigate the therapeutic potential of an anti-CD47 antibody alone and in combination with rituximab for the treatment of NHL. We predict that the combination of anti-CD47 antibody and rituximab through utilization of two independent antibody mechanisms will result in synergistic phagocytosis and elimination of NHL cells. We found that CD47 protein is highly expressed on primary human NHL cells compared to normal B cell counterparts. Higher CD47 gene expression predicted an inferior outcome in several cohorts of NHL patients, providing independent prognostic value. Blocking anti-CD47 antibodies preferentially enabled phagocytosis of NHL cells but not normal cell counterparts in vitro while the combination of anti-CD47 antibody and rituximab resulted in synergistic phagocytosis of NHL cells. In vivo, anti-CD47 antibody treatment of human NHL-engrafted mice reduced lymphoma burden and prolonged survival compared to IgG control treatment. Furthermore, anti-CD47 antibody treatment in combination with rituximab led to elimination of lymphoma and cure of NHL-engrafted mice compared to either antibody treatment as a single agent. The above in vivo results were observed in both a disseminated and localized human NHL cell line mouse model as well as in primary human lymphoma xenotransplants. These antibodies synergized through a novel mechanism combining Fc receptor (FcR)-dependent and FcR-independent stimulation of phagocytosis that might be applicable to many other cancers. Together, these data provide the rationale for utilizing an anti-CD47 antibody either alone or in combination with rituximab in treating human NHL. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2440.
DUAL ANTIPLATELET THERAPY AND OUTCOMES IN PATIENTS WITH ATRIAL FIBRILLATION AND ACUTE CORONARY SYNDROMES
Authors: Jonathan P. Piccini, Derek Cyr, Matthew Roe, Megan Neely, Felipe Martinez, Thomas Luscher, Renato Lopes, Kenneth Winters, Harvey White, Paul Armstrong, Keith Fox, Dorairaj Prabhakaran, Deepak Bhatt, E. Magnus Ohman, Ramon Corbalan
Journal: Journal of the American College of Cardiology (2014)
Pulse wave velocity and morphological changes associated with early atherosclerosis progression in the aortas of cynomolgus monkeys
Authors: D. J FARRAR, M G. BOND, J. K SAWYER, H. D GREEN
Journal: Cardiovascular Research (1984)

To determine the time course of changes in arterial stiffness and corresponding morphology during atherosclerosis progression, we determined pulse wave velocity (PWV) in cynomolgus monkeys fed atherogenic (test) and control diets over an 18-month period. At 6-month intervals, thoracic and abdominal aortic PWVs were determined with a pressure transducer retracted down the aorta in 5 cm increments. Iliac artery PWV was determined from the abdominal aortic pressure to a noninvasive femoral pulse. Groups of individual cardiac cycles, triggered by the ECGs, were sampled on a computer and the velocities (PWV) of the pulse wave fronts were calculated. There was no significant difference between groups until 18 months when test animal PWVs in the thoracic (7.44±0.83 m·s−1) and abdominal (8.52±0.67 m·s−1) aorta were significantly greater than those of controls (5.02±0.51 and 6.24±0.53 m·s−1, respectively), indicating increased arterial stiffness. There was no change in iliac PWV, 10.96±0.74 m·s−1 for 18-month test compared with 9.44±0.89 m·s−1 for controls. Constant infusion of nitroprusside and noradrenaline lowered and raised blood pressure and PWV in all groups, and PWV changes due to drug-induced pressure changes were greater in atherosclerotic than in control arteries. Systolic pressure of 18-month test and pulse pressure of 12- and 18-month test groups were significantly greater than controls under all drug conditions, also indicating increased vessel stiffness. Morphometric evaluation of histological aortic cross sections revealed early, noncomplicated atherosclerosis showing gradual increases in the ratio of intimal to medial cross-sectional area in the thoracic (1.24±0.30 after 18 months) and abdominal (1.70±0.42 after 18 months) aortas, compared with control ratios of essentially zero. The fraction of the internal elastic lamina covered with atherosclerotic lesions, and maximal intimal thickness also showed significant increases during the test diet period. These data show that early atherosclerosis resulted in aortic but not iliac stiffening which was detected by increased PWV before development of significant stenotic lesions.