tbuckley/cabot-search huggingface dataset:
Type V Hyperlipoproteinemia and Plasmapheresis
Authors: WERNER O. RICHTER
Journal: Annals of Internal Medicine (1987)

Letters and Corrections1 May 1987Type V Hyperlipoproteinemia and PlasmapheresisWERNER O. RICHTER, M.D., GERD BREHM, M.D., PETER SCHWANDT, M.D.WERNER O. RICHTER, M.D.Search for more papers by this author, GERD BREHM, M.D.Search for more papers by this author, PETER SCHWANDT, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-106-5-779_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Patients with excessive type V hyperlipoproteinemia develop several forms of abdominal pain that can be caused by three mechanisms: painful and tender spleen and liver, intestinal dysfunction, and pancreatitis (1-3). Pancreatitis is the most serious complication and can result in death (4). High serum levels of chylomicrons (triglycerides in concentrations greater than 1000 mg/dL) cause these complications through an increase in plasma viscosity (5); therefore, severe pancreatitis, intractable abdominal pain, and other complications such as seizures or gastrointestinal hemorrhage need to be treated by the induction of a rapid decrease in the level of chylomicrons in blood....References1. FALLATGLUECK RC. Familial and acquired type V hyperlipoproteinemia. Atherosclerosis. 1976;23:41-62. CrossrefMedlineGoogle Scholar2. GREENBERGBLACKWELDERLEVY BWR. Primary type V hyperlipoproteinemia: a descriptive study in 32 families. Ann Intern Med. 1977;87:526-34. LinkGoogle Scholar3. BROWNBAGINSKYEHNHOLM WMC. Primary type I and type V hyperlipoproteinemia. In: Hyperlipidemia: Diagnosis and Therapy. RIFKIND BM, LEVY RI, eds. New York: Grune & Stratton; 1977:93-112. Google Scholar4. FREDRICKSONLEVY DR. Familial hyperlipoproteinemia. In: The Metabolic Base of Inherited Disease. STANBURY JB, WYNGAARDEN JB, FREDRICKSON DS, eds. New York: McGraw-Hill; 1972:545-614. Google Scholar5. SEPLOWITZCHIENSMITH ASF. Effects of lipoproteins on plasma viscosity. Atherosclerosis. 1981;38:89-95. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Munich, Klinikum Grosshadern D-8000 Munich 70 West Germany PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByPlasma Exchange for Dramatic Gestational Hyperlipidemic PancreatitisTreatment of severe familial hypertriglyceridemia during pregnancy with very-low-fat diet and n-3 fatty acidsRole of LDL apheresis in the management of hypercholesterolaemiaPrognosis of DyslipoproteinemiaPlasmafiltration als Akuttherapie der exzessiven Hyperlipoproteinämie 1 May 1987Volume 106, Issue 5Page: 779-779KeywordsAbdominal painAttentionBlood plasmaEpileptic seizuresGastrointestinal hemorrhageLiverPancreatitisSpleen Issue Published: 1 May 1987 PDF DownloadLoading ...
Hazards of Process Regulations
Authors: Vincent P. Dole
Journal: JAMA (1992)

ACCORDING TO<i>Webster's Ninth New Collegiate Dictionary</i>, one definition of a<i>guideline</i>is a "rope to aid a passer over a difficult point." For a person walking a treacherous path in the mountains, grasping a guideline is sensible if the rope is well anchored and leads in the right direction. As an administrative metaphor, the implication is that guidelines for methadone programs are designed to be helpful to physicians making clinical decisions under conditions of uncertainty. Ideally they would generalize the experience of the most successful practitioners and provide guidance in such matters as optimal dosage, expectation of the length of treatment, and indications for supplementary services. <i>Regulations</i>are quite a different matter in both source and intent. As commands issued by an authority with power to punish, they are intended to deter wrongdoing and ensure conformity. Like speed limits, they are directed to a population of potential violators and
Dermatologists, university join in skin cancer study
Authors: P. Gunby
Journal: JAMA (1984)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Silicone foam sponge for pilonidal sinus: a new technique for dressing open granulating wounds.
Authors: R A Wood, L E Hughes
Journal: BMJ (1975)

A silicone foam sponge has been used to replace the daily packing of deep granulating wounds with moist sterile gauze. In the treatment of pilonidal sinus use of the sponge demands less nursing time and is more comfortable for the patient than the excision and open granulation technique. Patients can usually return to work soon after operation. The method has many applications in surgery, and widespread application of the technique to the management of granulating wounds could result in considerable savings to the NHS in money and skilled nursing time.
Stamp2 Controls Macrophage Inflammation through Nicotinamide Adenine Dinucleotide Phosphate Homeostasis and Protects against Atherosclerosis
Authors: Henrik ten Freyhaus, Ediz S. Calay, Abdullah Yalcin, Sara N. Vallerie, Ling Yang, Zerrin Z. Calay, Fahri Saatcioglu, Gökhan S. Hotamisligil
Journal: Cell Metabolism (2012)
Clinical and immunologic studies in reticular erythematous mucinosis and Jessner's lymphocytic infiltrate of skin
Authors: Suzanne W. Braddock, H. David Kay, Diane Maennle, Thomas L. McDonald, Samuel J. Pirruccello, Aneal Masih, Lynell W. Klassen, Alisa R. Sawka
Journal: Journal of the American Academy of Dermatology (1993)
Two-Embryo Transfer — The Future Looks Bright
Authors: David R. Meldrum, David K. Gardner
Journal: New England Journal of Medicine (1998)

In this issue of the Journal, Templeton and Morris describe the use of a large data base to define clinical factors that are predictive of pregnancy and of multiple gestation after in vitro fertilization.1 They conclude that when more than two embryos are available, the transfer of three embryos rather than two does not increase the pregnancy rate but increases the risk of multiple gestation by a factor of at least 1.1 if three or four eggs are fertilized in vitro and at least 1.5 if more than four eggs are fertilized in vitro.The first step in analyzing a . . .
Treatment of Polycythaemia with Radioactive Phosphorus
Authors: J. B. Harman, P. L. d. V. Hart, E. M. Ledlie
Journal: BMJ (1955)

meetings were held in 1915 and 1916, and by the end of the war the financial position of the Association was extremely bad.The turning-point came at the annual meeting in Halifax in 1921.It was realized then that reorganization was essential.The various provincial organizations had not been brought closely enough into relationship with the Association, and the finances needed immediate attention.A full-time secretary was appointed in the person of Dr. T. C. Routley, a bond issue was raised, and once more the Association began to expand.Within a few years it had paid off the bond issue and was showing the vigour and growth which has brought it to its present stature.The Association has continued not only to deal with the profession's educational and economic problems, but to concern itself with social and political developments.Post- graduate lectures were first organized in 1925, and were carried on throughout Canada for seven years, with the help of generous grants from the Sun Life Assurance Company.A Department of Hospital Service, also aided by this company, was carried on for 20 years.Health insurance has probably occupied the attention of the Association more continuously than has any other subject.The principle of insurance against the cost of ill- ness has received the support of the Association, particu- larly through the medium of prepaid medical care plans.The first proposals to establish a Royal College of Physicians and Surgeons of Canada were made at the annual meeting in Vancouver in 1920, the primary object being to stimulate study and postgraduate work in medicine and surgery.The idea gradually matured, and the College was finally incorporated by Act of Parliament in 1929.Once launched, the College became an entirely independent organization.Inspection and accreditation of hospitals is one of the later activities of the Association.This work had previously been done in Canada by the American College of Surgeons, and on their withdrawal from this particular field the Asso- ciation initiated plans for the necessary machinery to carry it on.To Dr. E. K. Lyon, of Leamington, Ont., is due most of the credit for focusing attention on the importance of this phase of hospital life and of eventually bringing into being the Commission to deal with it.The C.M.A. contributes the major part of the very heavy cost of this work.Formation of a College of General Practice originated
Branch point and donor splice-site<i>COL7A1</i>mutations in mild recessive dystrophic epidermolysis bullosa
Authors: B. Drera, G. Floriddia, F. Forzano, S. Barlati, G. Zambruno, M. Colombi, D. Castiglia
Journal: British Journal of Dermatology (2009)

Journal Article Branch point and donor splice‐site COL7A1 mutations in mild recessive dystrophic epidermolysis bullosa Get access B. Drera, B. Drera Division of Biology and Genetics, Department of Biomedical Sciences and Biotechnology, University of Brescia, viale Europa 11, 25123 Brescia, Italy Search for other works by this author on: Oxford Academic Google Scholar G. Floriddia, G. Floriddia Laboratory of Molecular and Cell Biology, Istituto Dermopatico dell’Immacolata–IRCCS, via dei Monti di Creta 104, 00167 Rome, Italy Search for other works by this author on: Oxford Academic Google Scholar F. Forzano, F. Forzano Laboratory of Genetics, E.O. Ospedali Galliera, via Volta 8, 16128 Genoa, Italy Search for other works by this author on: Oxford Academic Google Scholar S. Barlati, S. Barlati Division of Biology and Genetics, Department of Biomedical Sciences and Biotechnology, University of Brescia, viale Europa 11, 25123 Brescia, Italy Search for other works by this author on: Oxford Academic Google Scholar G. Zambruno, G. Zambruno Laboratory of Molecular and Cell Biology, Istituto Dermopatico dell’Immacolata–IRCCS, via dei Monti di Creta 104, 00167 Rome, Italy Search for other works by this author on: Oxford Academic Google Scholar M. Colombi, M. Colombi Division of Biology and Genetics, Department of Biomedical Sciences and Biotechnology, University of Brescia, viale Europa 11, 25123 Brescia, Italy Search for other works by this author on: Oxford Academic Google Scholar D. Castiglia D. Castiglia Laboratory of Molecular and Cell Biology, Istituto Dermopatico dell’Immacolata–IRCCS, via dei Monti di Creta 104, 00167 Rome, Italy Correspondence: Daniele Castiglia. E‐mail: d.castiglia@idi.it Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 161, Issue 2, 1 August 2009, Pages 464–467, https://doi.org/10.1111/j.1365-2133.2009.09114.x Published: 01 August 2009
Factors Associated With the Recommendation for Endocarditis Prophylaxis in Mitral Valve Prolapse
Authors: Carl J. Lavie
Journal: JAMA (1989)

We conducted a population-based study to examine the association between clinical and Doppler echocardiographic characteristics and physicians' recommendation for endocarditis prophylaxis. Of 127 consecutive Olmsted County, Minnesota, residents with newly documented isolated mitral valve prolapse, endocarditis prophylaxis was recommended three to four times more often in patients under 40 years compared with those more than 60 years of age. Using multiple logistic regression, for every 10-year increment in age, there was a 30% independent reduction in recommendations for endocarditis prophylaxis. Doppler evidence of mitral regurgitation was also independently associated with recommendations for endocarditis prophylaxis. Observations from physical examination, including systolic murmur and systolic click, were weakly associated with endocarditis prophylaxis recommendations. Mitral valve appearance (thickened vs not) was not associated with endocarditis prophylaxis. Although current recommendations for endocarditis prophylaxis and mitral valve prolapse do not address age and Doppler-detected mitral regurgitation, these variables are strongly associated with clinical decisions. Prospective, longitudinal, population-based studies are needed to define endocarditis risk further in subgroups with mitral valve prolapse to provide a more scientific basis for clinical decision making.
Soundings From BMJColumnists
Authors: Tony Miksanek
Journal: JAMA (1993)

Physicians write for many different reasons. While the impetus for writing is frequently utilitarian, it is also sometimes selfish. Not surprisingly, doctors write to educate, inform, and entertain but, along the way, may discover new meaning to their own lives. Writing offers physicians a mechanism whereby the responsibility and emotional burden of caring for thousands of patients can be reduced and resynthesized into a product of healing for the selfsame doctor. The average practice of medicine provides inspiration and material enough for countless tales of tragedy, love, heroism, and even miracles. Although such high drama is often limited to rough drafts known as histories and physicals, consultations, and office notes, once in a while, talented physician-authors can turn an examination of the throat into a raging battle of life and death or transform a drunken brute into a maharajah.<i>Soundings From</i>BMJ<i>Columnists</i>, however, suggests perhaps the most common reason
Continuity of health care for prisoners on release in England is worsening
Authors: A. Gulland
Journal: BMJ (2010)

Continuity of health care when prisoners are released is “inadequate” and seems to be getting worse, concludes a report by the Care Quality Commission and HM Inspectorate of Prisons.

The report, which is based on a sample of 21 primary care trusts (PCTs) that commission health care for prisons, says that continuity of health care around prisoners’ transfer and release is inadequate and getting worse.

Alex Baylis, programme manager at the commission, said, “People in prison are often not registered with a doctor and have a high prevalence of chaotic lifestyles, which can involve, for example, substance misuse …
Hepatitis B virus reactivation during therapy with ustekinumab for psoriasis in a hepatitis B surface-antigen-negative anti-HBs-positive patient
Authors: J. Koskinas, M. Tampaki, P.P. Doumba, E. Rallis
Journal: British Journal of Dermatology (2012)

Journal Article Hepatitis B virus reactivation during therapy with ustekinumab for psoriasis in a hepatitis B surface‐antigen‐negative anti‐HBs‐positive patient Get access J. Koskinas, J. Koskinas Academic Department of Medicine, Medical School of Athens, Hippokration General Hospital, 114 Vas. Sofias Avenue, 171 23, Athens, Greece Search for other works by this author on: Oxford Academic Google Scholar M. Tampaki, M. Tampaki Academic Department of Medicine, Medical School of Athens, Hippokration General Hospital, 114 Vas. Sofias Avenue, 171 23, Athens, Greece Search for other works by this author on: Oxford Academic Google Scholar P.P. Doumba, P.P. Doumba Academic Department of Medicine, Medical School of Athens, Hippokration General Hospital, 114 Vas. Sofias Avenue, 171 23, Athens, Greece Search for other works by this author on: Oxford Academic Google Scholar E. Rallis E. Rallis Department of Dermatology, Veterans Administration Hospital, Athens, Greece E‐mail: koskinas@ath.forthnet.gr Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 168, Issue 3, 1 March 2013, Pages 679–680, https://doi.org/10.1111/bjd.12120 Published: 01 March 2013
Sonic Hedgehog Pathway Promotes Metastasis and Lymphangiogenesis via Activation of Akt, EMT, and MMP-9 Pathway in Gastric Cancer
Authors: Young A. Yoo, Myoung Hee Kang, Hyun Joo Lee, Baek-hui Kim, Jong Kuk Park, Hyun Koo Kim, Jun Suk Kim, Sang Cheul Oh
Journal: Cancer Research (2011)

Activation of sonic hedgehog (Shh) signaling has been implicated in progression of a variety of tumors. In this study, we elucidated a role for Shh in the invasion of gastric tumors and determined the mechanism by which Shh is regulated. Immunohistochemical analysis of 178 primary human gastric tumor biopsies indicated that Shh expression was positively correlated with lymph node metastasis, high lymphatic vessel density, and poor prognosis. In mouse xenograft models of human gastric cancer, enforced expression of Shh significantly enhanced the incidence of lung metastasis compared with nonexpressing controls. Mechanistic investigations revealed that phosphoinositide 3-kinase (PI3K)/Akt inhibition blocked Shh-induced epithelial-mesenchyme transition, the activity of matrix metalloproteinase 9 (MMP-9), and lymphangiogenesis, reducing tumor invasiveness and metastasis. Taken together, our findings establish that Shh signaling promotes the metastasis of gastric cancer through activation of the PI3K/Akt pathway, which leads to mesenchymal transition and MMP-9 activation. These findings offer preclinical validation of Shh as a candidate therapeutic target for treatment of metastatic gastric cancers.
Hyperkalaemic ascending paralysis
Authors: E. Walter, N. Gibbins, A. Vandersteen, L. Kinton, P. Wark, M. Jonas
Journal: Journal of the Royal Society of Medicine (2004)

Figure 1 Axial neck magnetic resonance angiogram showing bilateral carotid arterial dissection and luminal occlusion of the left internal carotid artery, consistent with thrombus
The use of low molecular weight heparin–pluronic nanogels to impede liver fibrosis by inhibition the TGF-β/Smad signaling pathway
Authors: Ju-Hee Lee, Hyunseung Lee, Yoon Ki Joung, Kyung Hee Jung, Jong-Hoon Choi, Don-Haeng Lee, Ki Dong Park, Soon-Sun Hong
Journal: Biomaterials (2010)
Abdominal obesity and the "hypertriglyceridaemic waist" phenotype
Authors: P. Little
Journal: BMJ (2001)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following Abdominal obesity and the "hypertriglyceridaemic waist" phenotype Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Integrated PET/CT in Evaluating Sarcomatous Transformation in Osteochondromas
Authors: Nilendu C. Purandare, Venkatesh Rangarajan, Manish Agarwal, Anshu Rajnish Sharma, Sneha Shah, Abhishek Arora, Deep Shankar Parasar
Journal: Clinical Nuclear Medicine (2009)

Aim: To study the role of PET-CT in evaluating sarcomatous transformation in osteochondromas. Materials and Methods: This was a retrospective analysis of a prospective data base of 12 patients from 2005 to 2007 with a clinical diagnosis of an osteocartilaginous lesion who were referred for a FDG PET-CT study to evaluate for possible malignant transformation. Imaging was performed on a GE Discovery ST PET-CT system after intravenous injection of 370 MBq (10 mCi) of F-18 FDG. Results: Seven patients with histopathological evidence of a sarcomatous transformation to grade II chondrosarcoma showed moderate to high FDG uptake (SUV 3.3–6.9), whereas 1 patient with a dedifferentiated chondrosarcoma showed a focus of very intense uptake (SUV 11.4). Four patients with histopathological and/or clinical or follow-up diagnosis of a benign osteocartilaginous lesion showed low grade FDG uptake (SUV 0.8–1.3). FDG uptake was also noted in an asymptomatic osteochondroma which on histopathology revealed a grade II chondrosarcoma. Conclusions: Whole body FDG PET-CT is an important adjunct to conventional morphologic imaging in evaluating suspected malignant transformation in osteochondromas. Increased glucose metabolism can help diagnose sarcomatous transformation at the suspected sites as well as detect early malignant change at clinically unsuspected sites. Moreover, its ability to detect a focus of dedifferentiation can be useful for prognostication and to plan adjuvant treatment. A small cohort limits statistically sound conclusions to be drawn from this study, however further prospective trials based on these findings can help explore the potential application of FDG PET-CT in this clinical condition.
Genetic and catalytic efficiency structure of an HCV protease quasispecies
Authors: Sandra Franco, Mariona Parera, Ester Aparicio, Bonaventura Clotet, Miguel Angel Martinez
Journal: Hepatology (2007)

The HCV nonstructural protein (NS)3/4A serine protease is not only involved in viral polyprotein processing but also efficiently blocks the retinoic-acid–inducible gen I and Toll-like receptor 3 signaling pathways and contributes to virus persistence by enabling HCV to escape the interferon antiviral response. Therefore, the NS3/4A protease has emerged as an ideal target for the control of the disease and the development of new anti-HCV agents. Here, we analyzed, at a high resolution (approximately 100 individual clones), the HCV NS3 protease gene quasispecies from three infected individuals. Nucleotide heterogeneity of 49%, 84%, and 91% were identified, respectively, which created a dense net that linked different parts of the viral population. Minority variants having mutations involved in the acquisition of resistance to current NS3/4A protease inhibitors (PIs) were also found. A vast diversity of different catalytic efficiencies could be distinguished. Importantly, 67% of the analyzed enzymes displayed a detectable protease activity. Moreover, 35% of the minority individual variants showed similar or better catalytic efficiency than the master (most abundant) enzyme. Nevertheless, and in contrast to minority variants, master enzymes always displayed a high catalytic efficiency when different viral polyprotein cleavage sites were tested. Finally, genetic and catalytic efficiency differences were observed when the 3 quasispecies were compared, suggesting that different selective forces were acting in different infected individuals. Conclusion: The rugged HCV protease quasispecies landscape should be able to react to environmental changes that may threaten its survival. (HEPATOLOGY 2007;45:899–910.)