Effect of Low-Dose Continuous Estrogen and Progesterone Therapy with Calcium and Vitamin D on Bone in Elderly Women
Authors: Francisco R. Lafita, Belinda Garcia
Journal: Annals of Internal Medicine (2000)

Letters1 February 2000Effect of Low-Dose Continuous Estrogen and Progesterone Therapy with Calcium and Vitamin D on Bone in Elderly WomenFrancisco R. Lafita, MD, PhD and Belinda GarciaFrancisco R. Lafita, MD, PhDTarragona 43750, Spain (Lafita)Primary Care Center; Tarragona 43750, Spain (Garcia)Search for more papers by this author and Belinda GarciaTarragona 43750, Spain (Lafita)Primary Care Center; Tarragona 43750, Spain (Garcia)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-3-200002010-00013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Recker and colleagues' relevant study reports on how continuous low-dose hormone replacement therapy (HRT) with adequate calcium and vitamin D intake provides a bone-sparing effect in elderly women. The authors also found that no significant bone losses occurred in patients who received placebo plus calcium and vitamin D. The usefulness of bone mineral density measurements in the identification of persons with risk for bone fracture has recently been questioned (2). Other studies have addressed the importance of resorptive markers, such as pyridinolones and N-telopeptide, as indicators of active resorption and risk for fracture and as indicators of ...References1. Recker RR, Davies KM, Dowd RM, Heaney RP. The effect of low-dose continuous estrogen and progesterone therapy with calcium and vitamin D on bone in elderly women. A randomized, controlled trial. Ann Intern Med. 1999;130:897-904. LinkGoogle Scholar2. Wilkin TJ. Changing perception in osteoporosis. BMJ. 1999;318:862-5. CrossrefMedlineGoogle Scholar3. Riggs B, O'Fallon W, Muhs J, O'Connor M, Kumar R, Melton LJ. Long-term effects of calcium supplementation on serum parathyroid hormone level, bone turnover and bone loss in elderly women. J Bone Miner Res. 1998;13:168-74. CrossrefMedlineGoogle Scholar4. Amizuka N, Kwan MY, Goltzman D, Ozawa H, White JH. Vitamin D3 differentially regulates parathyroid hormone/parathyroid hormone-related peptide receptor expression in bone and cartilage. J Clin Invest. 1999;103:373-81. CrossrefMedlineGoogle Scholar5. LeBoff MS, Kohlmeier L, Hurwitz S, Franklin J, Wright J, Glowacki J. Occult vitamin D deficiency in postmenopausal US women with acute hip fracture. JAMA. 1999;281:1505-11. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Tarragona 43750, Spain (Lafita)Primary Care Center; Tarragona 43750, Spain (Garcia) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Effect of Low-Dose Continuous Estrogen and Progesterone Therapy with Calcium and Vitamin D on Bone in Elderly Women Robert R. Recker , K. Michael Davies , Rachel M. Dowd , and Robert P. Heaney Effect of Low-Dose Continuous Estrogen and Progesterone Therapy with Calcium and Vitamin D on Bone in Elderly Women Tom A. Elasy and Matthew J. Levinsky Effect of Low-Dose Continuous Estrogen and Progesterone Therapy with Calcium and Vitamin D on Bone in Elderly Women Jeffrey Brian Barnes and David T. Bess Effect of Low-Dose Continuous Estrogen and Progesterone Therapy with Calcium and Vitamin D on Bone in Elderly Women Robert R. Recker , Robert P. Heaney , and K. Michael Davies Metrics 1 February 2000Volume 132, Issue 3Page: 244KeywordsBone resorptionCalciumElderlyEstrogen replacement therapyEstrogensHormone replacement therapyOsteoporosisParathyroidProgesteroneVitamin D Issue Published: 1 February 2000 CopyrightCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...