tbuckley/cabot-search huggingface dataset:
Hypoplastic Anemia Associated With Metolazone
Authors: Kenneth Suh
Journal: JAMA (1979)

<h3>To the Editor.—</h3> Recently we followed up a patient who had transient hypoplastic anemia associated with metolazone. <h3>Report of a Case.—</h3> A 74-year-old woman had had mild hypertension for many years. In June 1977, 5 mg/day of metolazone was prescribed. There was resultant fair control of blood pressure. In August 1977, notable weakness developed. Moderate anemia was diagnosed, and the patient was given folic acid preparations in addition to other hematinies, including iron. Her condition worsened, and when referred to us in October, her hematocrit reading was 27.4%, with a reticulocyte count of 1.0%. The WBC, differential, and platelet counts were normal. Morphological examination of RBCs showed normochromia and normocytic pictures. Bone marrow aspiration showed hypoplastic marrow without suggestion of myeloproliferative disorders. Drug-induced marrow suppression was suspected, and metolazone therapy was stopped. The patient was given an anabolic agent (methandrostenolone) orally through mid-January 1978. Because of fluid retention, hypertension, and
IN-VITRO GLUCOCORTICOID STUDIES FOR PREDICTING RESPONSE TO GLUCOCORTICOID THERAPY IN ADULTS WITH MALIGNANT LYMPHOMA
Authors: ClaraD. Bloomfield, BruceA. Peterson, Joann Zaleskas, Glauco Frizzera, KendallA. Smith, Laurie Hildebrandt, KazimieraJ. Gajl-Peczalska, Allan Munck
Journal: The Lancet (1980)
Angiotensinogen Genotype Affects Renal and Adrenal Responses to Angiotensin II in Essential Hypertension
Authors: Paul N. Hopkins, Steven C. Hunt, Xavier Jeunemaitre, Barbara Smith, Daniel Solorio, Naomi D.L. Fisher, Norman K. Hollenberg, Gordon H. Williams
Journal: Circulation (2002)

Background — Renovascular and adrenal responses to infused angiotensin II (Ang II) are intermediate phenotypes that may indirectly reflect tissue renin-angiotensin system activity. We examine herein angiotensinogen ( AGT ) as a candidate gene to help elucidate potential mechanisms for previously reported AGT linkage and association studies. Methods and Results — Renal plasma flow and plasma aldosterone were measured before and after a 45-minute infusion of Ang II (3 ng · kg −1 · min −1 ) in 190 hypertensive patients who were on carefully controlled high- and low-salt diets. Reduced renal vascular ( P =0.0002) and adrenal ( P =0.002) responses to infused exogenous Ang II were associated with the AGT −6A allele. In multiple logistic regression, greater body mass index, lower basal renal plasma flow, and higher diastolic blood pressure together with AGT −6A genotype were associated with lower renal vascular response. In contrast, only male sex and AGT −6A genotype were associated with lower adrenal response. When both the renal and adrenal responses to Ang II were in the lowest tertile, the AGT −6AA genotype was present in 55.6%; in contrast, when both responses were in the upper 2 tertiles, the −6AA genotype was present in only 17.8% ( P =0.001). Conclusions — A clear association between AGT genotype and response to infused Ang II was demonstrated for both the renal vasculature and the adrenal, consistent with the hypothesis that the AGT −6A genotype results in increased tissue expression of angiotensinogen and Ang II.
Randomized Placebo-Controlled Trial of Oral Liquid Simethicone Prior to Upper Gastrointestinal Endoscopy
Authors: G. Bertoni, C. Gumina, R. Conigliaro, E. Ricci, J. Staffetti, M. G. Mortilla, D. Pacchione
Journal: Endoscopy (1992)

It has been suggested that pre-procedural oral simethicone improves visibility in upper GI tract endoscopy. We examined three-hundred-thirty patients referred for upper endoscopy who were randomized and were required to swallow a placebo solution or one of three liquid simethicone solutions 15 min prior to the examination. These solutions contained 65 mg, 65 mg and 195 mg of drug dissolved in 90 ml, 30 ml and 90 ml of water, respectively. Patients treated with both dosages of simethicone revealed significantly less foam and bubbles in both the stomach and the duodenum compared to placebo. Only the 90 ml volume adequately cleared both locations. The reduction of examination time could be found both in patients with an intact stomach and in patients with or without gastric bile reflux, but was most striking in patients with previous gastric resection (examination time being reduced by almost 50 % and the need of adjunctive lavage being reduced about 20 fold compared to placebo). In conclusion, pre-procedural oral simethicone should be routinely considered in patients with previous gastric resection. The utility of the drug is less evident in patients with normal gastric anatomy.
Echocardiographic, angiocardiographic, and surgical correlations in right ventricular myxoma simulating valvar pulmonic stenosis.
Authors: P A Chandraratna, S San Pedro, R C Elkins, N Grantham
Journal: Circulation (1977)

The echocardiographic, angiographic and surgical correlations in a patients with a right ventricular myxoma simulating valvar pulmonic stenosis are presented. A dense mass of echoes was seen in the body of the right ventricle in diastole; in the right ventricular outflow tract throughout the cardiac cycle; and within the pulmonic valve in systole. These echocardiographic findings suggested the presence of a mass high in the right ventricle, which moved throught the pulmonic valve in systole. This impression was confirmed by angiography and surgery. A 53 mmHg gradient across the pulmonic valve was noted at cardiac catheterization. At operation a myxoma which originated above the crista supraventricularis was found. The tumor moved into the main pulmonary artery in systole. Surgical removal of the tumor resulted in the disappearance of the abnormal echoes.
Management of Recurrent Urinary Tract Infections with Patient-Administered Single-Dose Therapy
Authors: Edward S. Wong, Mary McKEVITT, Kate Running, George W. Counts, Marvin Turck, Walter E. Stamm
Journal: Annals of Internal Medicine (1985)

In a randomized crossover trial, 38 women with recurrent urinary tract infections were assigned to use either continuous prophylaxis with trimethoprim-sulfamethoxazole or intermittent self-administered therapy (single-dose trimethoprim-sulfamethoxazole taken for acute urinary symptoms). The infection rate for patients on prophylaxis was 0.2 episodes/patient-year compared with 2.2 infections/patient-year for patients on self-administered therapy (p less than 0.001). Thirty-five of thirty-eight symptomatic episodes diagnosed by patients as infection were confirmed microbiologically, and 30 of the 35 infections responded clinically and microbiologically to patient-administered therapy with single-dose trimethoprim-sulfamethoxazole. No complications were seen in the 5 patients in whom therapy failed. The annual costs of prophylaxis and self-therapy were similar ($256 and $239, respectively) and both were less expensive than conventional therapy in women having 2 or more infections per year. In selected women, self-therapy is efficacious and economical compared with conventional therapy or prophylaxis.
Recurrent Otitis Media in Children
Authors: Adam B. Jackson, Ruby Kadota, Jonathan Gordon
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Problems Facing the Nursing Profession
Authors: John K. Iglehart
Journal: New England Journal of Medicine (1987)

The nation's hospitals, many of which are struggling in a new environment of prospective payment, reduced demand for their inpatient services, and increasing competition from physicians in ambulatory settings, have a new problem to confront: a shortage of registered nurses, the largest single professional discipline of the medical care delivery system. With a suddenness that surprised even long-time observers of cyclic shortages of nurses, the demand for registered nurses is outstripping the supply, and the factors that add up to this shortage suggest that there is no quick solution to the problem.The nursing shortage stems from a variety of . . .
Israel introduces generic drugs scheme
Authors: J. Siegel-Itzkovich
Journal: BMJ (1999)

Israeli pharmacists may now substitute cheaper generic versions of prescription drugs for brand name drugs if the prescribing doctor does not use the commercial name.

In addition, those working in both private and health fund pharmacies have been permitted to advise customers on over the counter drugs and suggest what is most suited to them.

These changes came into effect recently with amendments to the …
In vivo 3T spectroscopic quantification of liver fat content in nonalcoholic fatty liver disease: Correlation with biochemical method and morphometry
Authors: Ernesto Roldan-Valadez, Rafael Favila, Manuel Martínez-López, Misael Uribe, Camilo Ríos, Nahum Méndez-Sánchez
Journal: Journal of Hepatology (2010)
38. Inhibition of Apolipoprotein B-100 Expression by Lentivirus Mediated RNA Interference in Mice after Stem Cell Transduction and Transplantation
Authors: Mikko P. Turunen, Petri I. Makinen, Pia Leppanen, Juulia Enback, Suvi Koota, Tero Vatanen, Seppo Yla-Herttuala
Journal: Molecular Therapy (2005)
Sequential Vinorelbine and Docetaxel in Advanced Non-small Cell Lung Cancer Patients Age 70 and Older and/or with a Performance Status of 2: A Phase II Trial of the Southwest Oncology Group (S0027)
Authors: Paul J. Hesketh, Kari Chansky, Derick H.M. Lau, James H. Doroshow, Carol M. Moinpour, Robert A. Chapman, J Wendall Goodwin, Howard M. Gross, John J. Crowley, David R. Gandara
Journal: Journal of Thoracic Oncology (2006)
Nurselike cells express BAFF and APRIL, which can promote survival of chronic lymphocytic leukemia cells via a paracrine pathway distinct from that of SDF-1α
Authors: Mitsufumi Nishio, Tomoyuki Endo, Nobuhiro Tsukada, Junko Ohata, Shinichi Kitada, John C. Reed, Nathan J. Zvaifler, Thomas J. Kipps
Journal: Blood (2005)
Risk Stratification and Bedside Prognostication in Infective Endocarditis
Authors: Eric V. Granowitz, David L. Longworth
Journal: JAMA (2003)

Before the advent of antibiotics, infective endocarditis was almost always fatal. With the introduction of penicillin in 1941, endocarditis became a treatable disease. However, many patients still died, predominantly of congestive heart failure resulting from valve destruction.1
Comparing benefits and harms: the balance sheet
Authors: D. M. Eddy
Journal: JAMA (1990)

THE CENTRAL elements of a decision about a medical activity, and therefore the central elements of a policy statement, are the consequences of the interventions that are being considered—their benefits, harms, and costs. The estimates of health and economic outcomes condense the information from clinical research and clinical experience into a form suitable for decisions and provide the basis for judgments about the desirability of the intervention.  A simple but powerful way to present information on the outcomes of an intervention is the balance sheet. The idea is old and familiar; when you are trying to decide between two or more options that are complex and important, such as whether to buy a new car, make a list of the pros and cons of each option. The overall goal of the balance sheet is to help decision makers develop an accurate understanding of the important consequences of the different options.
Cutaneous side-effects of kinase inhibitors and blocking antibodies
Authors: Caroline Robert, Jean-Charles Soria, Alain Spatz, Axel Le Cesne, David Malka, Patricia Pautier, Janine Wechsler, Catherine Lhomme, Bernard Escudier, Valérie Boige, Jean-Pierre Armand, Thierry Le Chevalier
Journal: The Lancet Oncology (2005)
Abortion, Health, and the Law
Authors: Michael F. Greene, Jeffrey L. Ecker
Journal: New England Journal of Medicine (2004)

. . . with respect to his own feelings and circumstances, the most ordinary man or woman has means of knowledge immeasurably surpassing those that can be possessed by anyone else.— John Stuart Mill, On Liberty, 1859The signing into law of the Partial-Birth Abortion Ban Act of 2003 by President George W. Bush has brought to the surface, yet again, the bitterly divisive subject of abortion. Is this bill, as it states, simply an act intended to ban “a gruesome and inhumane procedure that is never medically necessary”?1 Or is it a carefully calculated first step in a . . .
John Morgan: Continental Doctor
Authors: Genevieve Miller
Journal: JAMA (1965)

The name of John Morgan is a familiar one in the history of American medical education and of colonial Philadelphia where he was responsible for creating the first American medical school in 1765. After a brilliant beginning his life ended in melancholy bitterness, with the promises of his youth unfulfilled. It is this tragic story that Whitfield J. Bell, Jr., PhD, narrates with scholarly objectivity and scrupulous documentation.  From painstakingly researched facts emerges the portrait of a man whose excessive ambition and stubborn determination elevated him to early greatness but also caused him to squander his productive years in exhausting efforts to preserve his reputation and to discredit a rival. As director-general of the General Hospital of the Continental Army from 1775 to 1777, Morgan was victimized by refractory regimental surgeons and a Congress unable to designate clear lines of authority in the Medical Department. After his dismissal he wasted
The “Practice” of Medicine
Authors: Michael Papper
Journal: Annals of Internal Medicine (2006)

On Being a Doctor15 August 2006The “Practice” of MedicineMichael Papper, MDMichael Papper, MDFrom University of Medicine and Dentistry of New Jersey, New Brunswick, NJ 08903.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-145-4-200608150-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Anyone becoming a doctor will at some point be told by a reluctant patient, “You're not practicing on me,” or “I'm not having a medical student or a resident learning on me.” Usually, what ensues is a cowardly exodus of the trainee from the patient's room, a quick plea to the attending physician, and either 1 of 2 scenarios: The trainee is demoted to observer status, with a visceral feeling of humiliation, or the attending physician makes the compelling argument to the patient that training in medicine is necessary and the patient concedes, leaving the poor trainee even more apprehensive ... Author, Article, and Disclosure InformationAffiliations: From University of Medicine and Dentistry of New Jersey, New Brunswick, NJ 08903.Corresponding Author: Michael Papper, MD, Department of Gastroenterology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, 51 French Street, MEB 478, New Brunswick, NJ 08903; e-mail, [email protected]edu. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 August 2006Volume 145, Issue 4Page: 308-309KeywordsAmmoniaAtrial fibrillationBloodEmotionsMedical dialysisMuscle proteinsNephrologyNeurologySelective serotonin reuptake inhibitorsUrea ePublished: 15 August 2006 Issue Published: 15 August 2006 Copyright & PermissionsCopyright © 2006 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Psychophysiological Disorders in Anxious Patients: Hypertension and Hypotension
Authors: Réjean Fontaine, Denis Boisvert
Journal: Psychotherapy and Psychosomatics (1982)

Anxious patients have a higher incidence than the general population for cardiovascular disorders and sudden death. Several studies have emphasized abnormal pulse rate, abnormal heart response conditioning, high incidence of arrhythmia, and abnormal blood pressure. Essential hypertension has been studied in relation to stress, and chronic hypotension ('low blood pressure syndrome') has been clinically recognized for decades, but rarely systematically studied. We investigated these abnormal blood pressures in anxious patients, during controlled trials with 80 patients having generalized anxiety disorder as defined in DSM III, for at least 6 months duration, and of moderate to severe intensity. They were randomly assigned to placebo, or bromazepam, 18 mg/day. Blood pressure, pulse, and several other measurements were taken on a weekly basis for 2 months (washout phase – 1 week, treatment phase – 4 weeks, and withdrawal phase – 3 weeks). One third of these patients had an abnormal blood pressure (hypertension or hypotension) while untreated, and this is statistically significant when compared to a matched control group of nonanxious patients. Bromazepam improved several patients having either hypertension or chronic hypotension. These findings are relevant for long-term treatment of anxious patients, since cardiovascular psychosomatic complications are a major health problem.
PML in a Patient with Lymphocytopenia Treated with Dimethyl Fumarate
Authors: Thorsten Rosenkranz, Mark Novas, Christoph Terborg
Journal: New England Journal of Medicine (2015)

The authors report a fatal case of progressive multifocal leukoencephalopathy in a 54-year-old woman in whom lymphocytopenia developed after treatment with delayed-release dimethyl fumarate for multiple sclerosis.
Silicone Breast Implants and the Risk of Connective-Tissue Diseases and Symptoms
Authors: Jorge Sánchez-Guerrero, Graham A. Colditz, Elizabeth W. Karlson, David J. Hunter, Frank E. Speizer, Matthew H. Liang
Journal: New England Journal of Medicine (1995)

Silicone breast implants have been linked to a variety of illnesses, the most controversial of which are connective-tissue diseases and symptoms. To study this relation, we analyzed data from 14 years of follow-up of the Nurses' Health Study cohort.
Effect of small interfering RNA on the expression of connective tissue growth factor and type I and III collagen in skin fibroblasts of patients with systemic sclerosis
Authors: R. Xiao, F-Y. Liu, J-Y. Luo, X-J. Yang, H-Q. Wen, Y-W. Su, K-L. Yan, Y-P. Li, Y-S. Liang
Journal: British Journal of Dermatology (2006)

Journal Article Effect of small interfering RNA on the expression of connective tissue growth factor and type I and III collagen in skin fibroblasts of patients with systemic sclerosis Get access R. Xiao, R. Xiao Departments of Dermatology and Nephrology, Second Xiangya Hospital, Central South University, 86 Ren‐Min Road, Changsha, Hunan 410011, China Rong Xiao. E‐mail: xiaorong@medmail.com.cn Search for other works by this author on: Oxford Academic Google Scholar F‐Y. Liu, F‐Y. Liu Departments of Dermatology and Nephrology, Second Xiangya Hospital, Central South University, 86 Ren‐Min Road, Changsha, Hunan 410011, China Search for other works by this author on: Oxford Academic Google Scholar J‐Y. Luo, J‐Y. Luo Departments of Dermatology and Nephrology, Second Xiangya Hospital, Central South University, 86 Ren‐Min Road, Changsha, Hunan 410011, China Search for other works by this author on: Oxford Academic Google Scholar X‐J. Yang, X‐J. Yang Departments of Dermatology and Nephrology, Second Xiangya Hospital, Central South University, 86 Ren‐Min Road, Changsha, Hunan 410011, China Search for other works by this author on: Oxford Academic Google Scholar H‐Q. Wen, H‐Q. Wen Departments of Dermatology and Nephrology, Second Xiangya Hospital, Central South University, 86 Ren‐Min Road, Changsha, Hunan 410011, China Search for other works by this author on: Oxford Academic Google Scholar Y‐W. Su, Y‐W. Su Departments of Dermatology and Nephrology, Second Xiangya Hospital, Central South University, 86 Ren‐Min Road, Changsha, Hunan 410011, China Search for other works by this author on: Oxford Academic Google Scholar K‐L. Yan, K‐L. Yan Departments of Dermatology and Nephrology, Second Xiangya Hospital, Central South University, 86 Ren‐Min Road, Changsha, Hunan 410011, China Search for other works by this author on: Oxford Academic Google Scholar Y‐P. Li, Y‐P. Li Departments of Dermatology and Nephrology, Second Xiangya Hospital, Central South University, 86 Ren‐Min Road, Changsha, Hunan 410011, China Search for other works by this author on: Oxford Academic Google Scholar Y‐S. Liang Y‐S. Liang Departments of Dermatology and Nephrology, Second Xiangya Hospital, Central South University, 86 Ren‐Min Road, Changsha, Hunan 410011, China Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 155, Issue 6, 1 December 2006, Pages 1145–1153, https://doi.org/10.1111/j.1365-2133.2006.07438.x Published: 01 December 2006 Article history Accepted: 23 April 2006 Published: 01 December 2006
A STUDY OF BRAIN INFECTIONS WITH THE PNEUMOCOCCUS.
Authors: E. E. SOUTHARD
Journal: JAMA (1906)

these specimens of urine have a few red blood cells in the sediment.Functionally the kidney is almost per- fect.Later, however, and this includes all the cases mentioned, the kidneys are the seat of an acute process, the amount of urine diminishes, the specific gravity rises and albumin and sediment increase so that from the urine alone one would suspect an acute exacerbation of an acute nephritis in a kidney of much greater weight than he finds at autopsy.In certain other cases, how- ever, in which it is not the renal symptoms which pre- dominate at death, the amount of urine may grow larger and larger until a permanent catheter is neces- sary, the patient dying in uremia.În 7 of these cases hyalin was present in the capillaries.In one, with combined weight 155 grams, albu- min was 0.3 per cent., casts small in number, and when present hyaline and granular.In one of 220 grams' weight the albumin was 1.2 per cent, and the casts in large numbers, hyaline, granular and especially waxy and fatty.