Immunoglobulin M Antibody to Hepatitis B Core Antigen and Fulminant Hepatitis B
Authors: STUART C. GORDON
Journal: Annals of Internal Medicine (1985)

Letters and Corrections1 March 1985Immunoglobulin M Antibody to Hepatitis B Core Antigen and Fulminant Hepatitis BSTUART C. GORDON, M.D., LENNOX J. JEFFERS, M.D., MARIA D. DE MEDINA, B.S., K. RAJENDER REDDY, M.D., EUGENE R. SCHIFF, M.D.STUART C. GORDON, M.D.Search for more papers by this author, LENNOX J. JEFFERS, M.D.Search for more papers by this author, MARIA D. DE MEDINA, B.S.Search for more papers by this author, K. RAJENDER REDDY, M.D.Search for more papers by this author, EUGENE R. SCHIFF, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-102-3-415_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Fulminant hepatitis B, characterized by deepening jaundice, encephalopathy, coagulopathy, and coma, is an uncommon and frequently fatal complication of a common viral disease. Because the absence of hepatitis B surface antigen (HBsAg) does not preclude the diagnosis of fulminant type B hepatitis, the serum IgM antibody to hepatitis B core antigen (anti-HBc) has been advocated as a useful diagnostic variable. We report the cases of two patients with fulminant hepatitis B, with strongly positive antibody to the hepatitis B surface antigen (anti-HBs) at or near the time of admission, in whom the IgM anti-HBc proved to be...References1. TABORGERETYHOOFNAGLEBARKER ERJL. Immune response in fulminant viral hepatitis, type B. Gastroenterology. 1976;71:635-40. CrossrefMedlineGoogle Scholar2. TABORKRUGMANWEISSGERETY ESER. Disappearance of hepatitis B surface antigen during an unusual case of fulminant hepatitis B. J Med Virol. 1981;8:277-82. CrossrefMedlineGoogle Scholar3. WOLFFEL SHEIKHCULLENS INH. Enhanced HBsAg production in pathogenesis of fulminant viral hepatitis type B. Br Med J. 1976;2:669-71. CrossrefMedlineGoogle Scholar4. KRYGERALDERSHVILEMATHIESENNIELSEN PJLJ. Acute type B hepatitis among HBsAg negative patients detected by anti-HBc IgM. Hepatology. 1982;2:50-3. CrossrefMedlineGoogle Scholar5. SHIMIZUOHYAMATAKAHASHI MMY. Immunoglobulin M antibody against hepatitis B core antigen for the diagnosis of fulminant type B hepatitis. Gastroenterology. 1983;84:604-10. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: STUART C. GORDON, M.D.; LENNOX J. JEFFERS, M.D.; MARIA D. DE MEDINA, B.S.; K. RAJENDER REDDY, M.D.; EUGENE R. SCHIFF, M.D.Affiliations: University of Miami School of Medicine Miami, FL 33101 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDiagnostic Significance of Anti-HBcIgM Prevalence Related to Symptoms in Canadian Patients Acutely or Chronically Infected With Hepatitis B VirusCutoff levels of immunoglobulin M antibody against viral core antigen for differentiation of acute, chronic, and past hepatitis B virus infections 1 March 1985Volume 102, Issue 3Page: 415-416KeywordsAntigensBrain diseasesCoagulopathyComaHepatitis AHepatitis BHepatitis B surface antigenViral diseases ePublished: 1 December 2008 Issue Published: 1 March 1985 PDF downloadLoading ...