tbuckley/cabot-search huggingface dataset:
The rights of HIV infected healthcare workers
Authors: P. Erridge
Journal: BMJ (1996)

place in a primary care setting.The outcome ofthe government's listening process, and the further consultation that the Departnent of Health will now be starting, are occuning alongside a parallel exercise by the BMA's General Medical Services Committee, of consultation with the profession leading to policy evolution and contractual reform.Those developments, together with what now seems to be a shared belief in the merit of evaluated pilot schemes, suggest that we may at last be moving away from imposed solutions and towards evidence based policy mak- ing, consultation, and negotiated change, in a manner that should act to the advantage of all those who work in primary care and 1 Secretaries of State for Social Services, Wales, Northern Ireland, and Scotland.Primary health care: an agenda for discussion.
The Application of Hypnosis to Psychotherapy
Authors: Fred H. Frankel
Journal: Psychotherapy and Psychosomatics (1975)

Research Articles| February 12 2010 The Application of Hypnosis to Psychotherapy Subject Area: Psychiatry and Psychology Fred H. Frankel Fred H. Frankel Beth Israel Hospital, Boston, Mass. Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1975) 25 (1-6): 20–25. https://doi.org/10.1159/000286824 Article history Published Online: February 12 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Fred H. Frankel; The Application of Hypnosis to Psychotherapy. Psychother Psychosom 31 December 1975; 25 (1-6): 20–25. https://doi.org/10.1159/000286824 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search This content is only available via PDF. 1975Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Article PDF first page preview Close Modal You do not currently have access to this content.
Frederick Leonard Richardson
Authors: Michael Drury
Journal: BMJ (2004)

Psychiatrist and pioneer of the death-and-dying movementIn her groundbreaking bestseller On Death and Dying, Elisabeth Kübler-Ross overturned how physicians treat dying patients.When the book was published in 1969, death was a taboo subject and discussing it was considered morbid.Patients died alone in hospitals; physicians ignored them; and adequate pain medication was underused.The book brought these practices to the fore-and pressed for more humane treatment of the dying.The book rocked the medical profession-and at the same time also resulted in a public outcry for compassionate care of the dying.On Death and Dying is a classic work and is still in print around the world today.Kübler-Ross's work stemmed from the realisation that in her native Switzerland, death, like birth, was considered a normal part of the life cycle.In Switzerland people died at home surrounded by family and friends-and they were comfortable until the end of their lives.In contrast in the United States and other countries that placed a premium on high tech medicine, patients lay by the wayside.It was a practice she deplored.A hallmark of Kübler-Ross's work was her emphasis on communication.She stressed that patients truly wanted to review their lives, their deterioration, and imminent death.When patients and doctors could talk openly-and without fear-a good death could be achieved.In 1967 Kübler-Ross began interviewing dying patients at the University of Chicago's Billings Hospital, where she was a psychiatrist.She hoped to learn what patients were thinking as they lay dying.From her first hand research, she derived the famous five stage framework: denial, anger, bargaining, depression, and acceptance-or, as she called it, "one common denominator" of death and dying.The model outlined how patients with terminal illness grappled with their diagnosis, and their emotions along the way, right through to acceptance of their impending death.She appealed to the medical community to use it.Collin Murray Parkes, consultant psychiatrist at St Christopher's Hospice in London, credits Kübler-Ross's five stage framework and its high visibility as a driving force in stimulating research and changing
Abstract 1292: Pharmacokinetics of CPX-351: A nano-scale liposomal fixed molar ratio of cytarabine-daunorubicin (Cyt:Daun) in patients with advanced leukemia
Authors: Eric J. Feldman, Jeffrey E. Lancet, Jonathan E. Kolitz, John M. Trang, Lawrence D. Mayer, Chris E. Swenson, Michael T. Chiarella, Arthur C. Louie
Journal: Cancer Research (2011)

Abstract Background: CPX-351 is a liposomal formulation that co-encapsulates Cyt and Daun enabling delivery of both drugs at a synergistic 5:1 molar ratio. A Phase I study in advanced AML patients demonstrated substantial efficacy with complete remissions (CRs) and acceptable safety. The MTD was 101 units/m2. One unit of CPX-351 contains 1 mg Cyt and 0.44mg of Daun. Here we examine the PK of CPX-351 as a function of dose, inter-patient variability and patient characteristics in order to identify potential PD relationships. Methods: 35 male and female patients with advanced hematologic malignancies were included in the PK portion of this Phase I trial and received 24, 32, 43, 57, 76, 101, or 134 units/m2 of CPX-351 by IV infusion over 90 minutes on Days 1, 3, and 5. Validated LC/MS/MS assays were used for determination of total plasma Cyt and Daun. PK parameters [Cmax, AUC, t1/2, Vss, CL, Cmax/Dose, AUC/Dose] were determined on Days 1 and 5. Results: Mean Cyt and Daun PK parameters are presented in the table below. No significant differences were observed in t1/2, Vss, CL, Cmax/Dose, or AUC/Dose among dose groups on either study day, although some drug accumulation was observed from day 1 to day 5. Cyt and Daun PK parameters were not correlated with patient gender, age or race. Incidence of non-hematologic toxicity increased with dose and systemic exposure. CRs were observed in patients receiving doses of 32-134 units/m2 of CPX-351. The responses at 101 units/m2 and above appear to be more durable. The Cyt:Daun molar ratio remained near 5:1 for up to 48 hours on both study days for all dose levels. Conclusions: Cyt and Daun delivered in CPX-351 exhibited linear single dose and multiple dose PK and low inter-patient variability in plasma concentrations within dose groups. CPX-351 provides predictable, extended systemic exposure of elevated Cyt:Daun concentrations near a 5:1 molar ratio. The 100 unit/m2 dose is undergoing testing in Phase II studies. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1292. doi:10.1158/1538-7445.AM2011-1292
Targeting the c-Met/FZD8 Signaling Axis Eliminates Patient-Derived Cancer Stem–like Cells in Head and Neck Squamous Carcinomas
Authors: Shuyang Sun, Suling Liu, Sheng Zhong Duan, Lei Zhang, Henghua Zhou, Yongjie Hu, Xianghui Zhou, Chaoji Shi, Rong Zhou, Zhiyuan Zhang
Journal: Cancer Research (2014)

Abstract Cancer stem–like cells (CSC) thought to contribute to head and neck squamous carcinomas (HNSCC) may offer attractive therapeutic targets if a tractable approach can be developed. In this study, we report that silencing c-Met is sufficient to suppress sphere formation, tumor initiation, and metastatic properties of HN-CSC. Pharmacologic inhibition of c-Met with the selective inhibitor PF-2341066 preferentially targeted CSC and synergized with conventional chemotherapy to improve efficacy in a mouse xenograft model of HNSCC, impeding tumor growth and reducing metastasis. Mechanistic investigations showed that CSC elimination was due to downregulation of Wnt/β-catenin signaling in HN-CSC and that the Wnt pathway receptor FZD8 was essential for interactions of c-Met and Wnt/β-catenin signaling in HN-CSC. Notably, ectopic expression of FZD8 rescued the impaired phenotype of HN-CSC where c-Met was inhibited. Furthermore, c-Met upregulated FZD8 through the ERK/c-Fos cascade in HN-CSC. Taken together, our results offer a preclinical proof-of-concept for targeting the c-Met/FZD8 signaling axis as a CSC-directed therapy to improve HNSCC treatment. Cancer Res; 74(24); 7546–59. ©2014 AACR.
Doctor who abducted her daughter and took her to Pakistan is struck off
Authors: C. Dyer
Journal: BMJ (2013)

A doctor who abducted her six year old daughter from her estranged husband nearly two years ago and took her to Pakistan has been struck off by a panel of the Medical Practitioners Tribunal Service (MPTS).

Humma Fazal Dar, 39, was allowed to keep her daughter Aamina on three weekends each month after a 2008 court battle that awarded custody of the child to her ex-husband Safraz Khan of Croydon, south London, who …
Colonoscopy completion rates: Author's reply
Authors: Mark R Welfare
Journal: BMJ (2004)

Olfactory detection of human bladder cancer by dogs Cause or association?Editor-The study by Willis et al, testing whether dogs can detect signs of bladder cancer in urine, may be the occasion for an amusing cover for the BMJ but this should not be an excuse for relaxing intellectual rigor when assessing the experiment. 1 Neither the authors nor the commentator point out that the study design is unable to distinguish cause from association-a basic logical error.The dogs may be detecting "tumour related volatile compounds" or they may be detecting a substance in the urine that is associated with an increased risk of cancer.The most obvious candidate would be from cigarette smoking, which would be rather unoriginal, but it could also be other as yet unidentified substances.Furthermore, while the dogs may only be 41% accurate at detecting urine from people already diagnosed with cancer, the results would also be consistent with a higher accuracy for detecting patients at risk of cancer.The authors should follow up their interesting preliminary study rigorously and the BMJ should stick to the Christmas edition for letting down its usual standards of review.
Pseudomonas aeruginosa Infections: Persisting Problems and Current Research to Find New Therapies
Authors: HERBERT Y. REYNOLDS
Journal: Annals of Internal Medicine (1975)

Despite the availability of specific antibiotics, Pseudomonas aeruginosa bacteria still cause troublesome infections in patients with a variety of illnesses: extensive thermal injury, leukopenia from antineoplastic chemotherapy and other forms of immunosuppressive treatment, chronic pulmonary disease such as cystic fibrosis, or intravenous narcotic use. The use of antibiotics has improved the prognosis of pseudomonas infections considerably. However, patients with marginal or defective host immunity may need more extensive therapy to master the infection. By evaluating additional modalities of treatment such as granulocyte replacement, improved usage of antibiotics, and active (prophylaxis) or passive antibody administration, the optimal combination may be found.
Neural Activity and Ventricular Fibrillation
Authors: Howard L. Bleich, Emily S. Boro, Bernard Lown, Richard L. Verrier
Journal: New England Journal of Medicine (1976)

Ventricular fibrillation is the likely mechanism for sudden death and the leading cause of fatality among patients with coronary heart disease. In this country alone, ventricular fibrillation claims about 450,000 lives per year. Since prolonged survival is possible after resuscitation, the catastrophic arrhythmia seems to represent an electrical accident rather than the culmination of extensive, irreversible structural damage to the heart.1 Indeed, in most cases of sudden death pathological studies have failed to uncover acute lesions either in the coronary arteries or in the myocardium. How, then, is the heart catapulted into such disorganized electrical activity?Two related hypotheses directed . . .
The Unborn Patient
Authors: Warren J. Warwick
Journal: JAMA (1969)

Gregg and Hutchinson (p 1059) tell of 15 infants who would probably have died as fetuses save for intrauterine exchange transfusion and who, at an average age of 2 years, have normal physical and mental development. Their report confirms the hopes that have led mothers and physicians to accept risks, discomforts, and complications in order that the techniques of intrauterine exchange transfusion might be developed and refined. The report will also be a stimulus for the many who have watched such studies with reservations to undertake treatment of the unborn child with isoimmune hemolytic disease.  Most important, however, the report will compel us to enlarge our concepts of the patient-doctor contract, the contract that exists whenever there is a sick patient and a doctor who will provide care. The qualities of choice, knowledge, and direct interaction that are crucial to the doctor-patient relationship are not basic to the patient-doctor contract.
Tc-99m PYP Localization in Calf Muscle Necrosis
Authors: SUSHLIA VIRUPANNAVAR, PARVEZ H. SHIRAZI, NANDA V KHEDKAR, ERVIN KAPLAN
Journal: Clinical Nuclear Medicine (1984)

Tc-99m pyrophosphate (PYP) can localize in an acute myocardial infarct and other extraosseous lesions, including soft tissue necrosis and severe cellular injury A case of Tc-99m PYP uptake in calf muscle necrosis following transfemoral cardiac catheterization is presented. This was incidentally detected on Tc-99m PYP imaging performed for an acute myocardial infarction. Repeat Tc-99m PYP imaging one month later was normal, implying resolution of the ischemic muscle necrosis.
Implications of Stroke Risk Criteria on the Anticoagulation Decision in Nonvalvular Atrial Fibrillation
Authors: Alan S. Go, Elaine M. Hylek, Kathleen A. Phillips, Leila H. Borowsky, Lori E. Henault, YuChiao Chang, Joe V. Selby, Daniel E. Singer
Journal: Circulation (2000)

Background —Warfarin dramatically reduces the risk of stroke in patients with nonvalvular atrial fibrillation (NVAF) but increases the likelihood of bleeding. Accurately identifying patients who need anticoagulation is critical. We assessed the potential impact of prominent stroke risk classification schemes on this decision in a large sample of patients with NVAF. Methods and Results —We used clinical and electrocardiographic databases to identify 13 559 ambulatory patients with NVAF from July 1996 through December 1997. We compared the proportion of patients classified as having a low enough stroke risk to receive aspirin using published criteria from the Atrial Fibrillation Investigators (AFI), American College of Chest Physicians (ACCP), and the Stroke Prevention in Atrial Fibrillation Investigators (SPAF). In this cohort, AFI criteria classified 11% as having a low stroke risk, compared with 23% for ACCP and 29% for SPAF (κ range, 0.44 to 0.85). This 2- to-3-fold increase in low stroke risk patients by ACCP and SPAF criteria primarily resulted from the inclusion of many older subjects (65 to 75 years±men &gt;75 years) with no additional clinical stroke risk factors. Conclusions —The age threshold for assigning an increased stroke risk has a dramatic impact on whether to recommend warfarin in populations of patients with NVAF. Large, prospective studies with many stroke events are needed to precisely determine the relationship of age to stroke risk in AF and to identify which AF subgroups are at a sufficiently low stroke risk to forego anticoagulation.
Philip John Russel Nichols, MA,DM,FRCP,DPhysMed.
Authors: P Wood
Journal: Annals of the Rheumatic Diseases (1980)

Thrombocytosis in giant cell arteritisSir, The interesting paper of Bergstrom and colleagues' comes to the conclusion that thombocytosis in giant cell arteritis is reactive to the inflammation present in this disease.We came by other ways to the same conclusion.24We evaluated platelet counts in 146 cases of rheumatoid arthritis, in 43 cases ofjuvenile chronic arthritis (22 cases of juvenile rheumatoid arthritis 6 Still's patients, and 15 cases of juvenile mono-oligoarthritis), in 7 patients with Sj6gren's syndrome, in 41 with progressive systemic sclerosis, in 11 with rheumatic polymyalgia with or without Horton's arteritis, in 29 with ankylosing spondy- litis, in 34 with psoriatic arthritis, and in 17withgout.In all the groups of patients, except for juvenile mono-oligo- arthritis, we found mean platelet counts greater than those in control subjects 214 500 ± 32 886/mms (214 ± 33 x 109/1) by the method of Palumbo and DiniO.A clear thrombocytosis was present only in a percentage of the patients of the different groups.In these thrombocytosis patients there was a higher disease activity.Furthermore, we found a positive correlation between ESR and platelet count, serum mucoproteins, and platelet count; and a negative correlation between serum iron and platelet count.Therefore it is possible to assume that thrombo- cytosis is an inflammation index in rheumatic and con- nective tissue diseases.The researches of Bergstrom and colleagues are an elegant confirmation of this assumption.
Patient Privacy and Secondary Use of Administrative Databases-Reply
Authors: Zita Lazzarini
Journal: JAMA (1996)

<h3>In Reply.</h3> —Drs Kumar and Lucey insightfully present a classic illustration of the trade-offs between the public benefits of health information and the need to protect personal privacy. Secondary uses of administrative claims in the health care system can provide powerful public health benefits ranging from identification of barriers to health care access, improvement in outcomes research, and prevention of nosocomial infections to cost control and detection of fraud. At the same time, matching of patient records in numerous databases, perhaps with the use of a unique identifier such as the Social Security number, can pose a powerful threat to personal privacy. The research and policy question then becomes the following: How can society facilitate the secondary use of health information through standardized data sets and increased automation while at the same time protecting patient privacy? This tension perhaps is not capable of full resolution. Yet, in our work on health care
PRINCIPLES OF THE DIETETIC TREATMENT OF DIABETES MELLITUS.
Authors: C. W. PURDY
Journal: JAMA (1898)

I have been greatly honored by this society in an invitation to present before its members some of my views upon diabetes. While such a task is by no means an unpleasant one, in view of the great intrinsic interest of the subject, the importance of the class of cases in clinical practice and, lastly, the familiarity of the picture to my mind, in consequence of having with considerable care and thought gone over this field with special interest for a number of years. I must, however, confess some hesitation in the undertaking, since very divergent views have been held upon the subject by so many eminent observers, not only as to the etiology and pathology of the disease, but also as regards its proper management. In addition to this the literature of the disease—which is prodigious in volume—is yet so inharmonious and even contradictory, as a whole, that it
Complete amino acid sequence of heavy chain variable regions derived from two monoclonal anti-p-azophenylarsonate antibodies of BALB/c mice expressing the major cross-reactive idiotype of the A/J strain.
Authors: K Meek, D Jeske, M Slaoui, O Leo, J Urbain, J D Capra
Journal: The Journal of Experimental Medicine (1984)

The primary structure of A/J anti-p-azophenylarsonate (anti-Ars) antibodies expressing the major A-strain cross-reactive idiotype (CRIA) has provided important insights into issues of antibody diversity and the molecular basis of idiotypy in this important model system. Until recently, this idiotype was thought to be rarely, if ever, expressed in BALB/c mice. Indeed, it has been reported that BALB/c mice lack the heavy chain variable segment (VH) gene that is utilized by the entire family of anti-Ars antibodies expressing the A/J CRI. Recently, however, it has been possible to elicit CRIA+, Ars binding antibodies in the BALB/c strain by immunizing first with anti-CRI and then with antigen. Such BALB/c, CRIA+ anti-Ars antibodies can be induced occasionally with antigen alone. VH region amino acid sequences are described for two CRIA+ hybridoma products derived from BALB/c mice. While remarkably similar to each other, their VH segments (1-98) differ from the VH segments of A/J CRIA+, anti-Ars antibodies in over 40 positions. Rather than the usual JH2 gene segment used by most A/J CRIA+ anti-Ars antibodies, one BALB/c CRIA+ hybridoma utilizes a JH1 gene segment, while the other uses a JH4. However, the D segments of both of the BALB/c antibodies are remarkably homologous to the D segments of several A/J CRIA+ antibodies sequenced previously, as are the amino terminal amino acid sequences of their light chains. These data imply that BALB/c mice express the A/J CRIA by producing antibodies with very similar, if not identical, light chain and heavy chain D segments, but in the context of different VH and JH gene segments than their A/J counterparts. The results document that molecules that share serologic specificities can have vastly different primary structures.
'Beverly Hills, 90210': The Lap Belts Don't Show on TV
Authors: Michele A. Hamilton
Journal: JAMA (1992)

<h3>To the Editor.</h3> —Safety-belt wearers who sustain motor vehicle accidents have an approximate two-thirds reduction in severity of injury, hospital admissions, and hospital charges.<sup>1</sup>Unfortunately, young adults are among those least likely to wear safety belts.<sup>2</sup> "Beverly Hills, 90210" is a popular television show among young adult viewers. The stars are 17-year-old fraternal twins (one boy, one girl) who are both licensed drivers. Although these two "role models" do a lot of driving, consistent with the show's Southern California milieu, neither actor ever buckles up. The producers of this show should insist that the actors wear safety belts during the show's filming. This seemingly innocuous procedure might encourage young adult viewers to wear their safety belts and might reduce the head and facial injury rate in this age group.