tbuckley/cabot-search huggingface dataset:
A Call to Action for Pre–End-Stage Renal Disease Care
Authors: Thomas S. Huber
Journal: JAMA Surgery (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Grasping at Straws
Authors: Howard Markel
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
POTENTIATION OF PRIMARY VIRUS INFECTION BY RADIOMIMETIC DRUGS
Authors: T. W. E. Robinson
Journal: British Journal of Dermatology (1970)

Journal Article POTENTIATION OF PRIMARY VIRUS INFECTION BY RADIOMIMETIC DRUGS Get access T. W. E. Robinson T. W. E. Robinson University College Hospital Gower Street, W. C. I Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 82, Issue 3, 1 March 1970, Pages 311–313, https://doi.org/10.1111/j.1365-2133.1970.tb12443.x Published: 01 March 1970
METHOD OF STATING BLOOD SUGAR DETERMINATIONS
Authors: Solomon Strouse
Journal: JAMA (1923)

To the Editor:  —I should like to suggest that an effort be made to change the method commonly used of expressing blood sugar as percentage values.  In discussion with several men, I find that the tendency has been to change into the form used for other blood chemical determinations, milligrams per hundred cubic centimeters. This would make the matter easier to write out and would make blood sugar conform with blood urea and other nitrogenous constituents of the blood.
Points from Letters: Petechiae from Vests
Authors: R. P. Carrington
Journal: BMJ (1965)

SIR,-The Times of 6 September had an interesting article concerning medical matters under the title " If Single-Handed Doctors Go."It was regretted that much of the personal touch will be lost.The grouping would, however, diminish the strain of unlimited liability which presses heavily on the single doctor.What other individuals or organization in the country would accept unlimited liability for service, particularly when the liability carries heavy penalties for the doctor and none for the individuals who abuse the service ?Surely this matter deserves more attention ?Could even a full-time salaried service carry the burden without restrictions on the user's side ?At present the sky is the limit.Some need aid, but that is no reason for giving it to all without restraint.There is no need, in effect, to burn the house down to get roast pig.-I am, etc.,
[681] STAGING OF FIBROSIS BY LIVER STIFFNESS MEASUREMENT IN THALASSEMICS WITH IRON OVERLOAD
Authors: V. Di Marco, F. Bronte, D. Cabibi, F. Barbaria, Z. Borsellino, G. Alaimo, S. Ciminnisi, M. Capra, A. Maggio, P.L. Almasio, A. Craxi
Journal: Journal of Hepatology (2007)
Half of physicians are unaware of surveillance system for Creutzfeldt-Jakob disease
Authors: A. Franks, M. Schweiger
Journal: BMJ (1996)

EDITOR,—Surveillance of disease is crucial in the development of control strategies, and particularly so for infectious diseases. Will et al recently hypothesised that a newly described variant of Creutzfeldt-Jakob disease is causally linked to bovine spongiform encephalopathy.1

The epidemiological value of a surveillance …
Selecting a Specialist
Authors: Niteesh K. Choudhry, Joshua M. Liao, Allan S. Detsky
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CORONARY OCCLUSION IN A PATIENT AGED TWENTY-FOUR YEARS
Authors: P. B. Fernando
Journal: BMJ (1935)

<h3>SUMMARY</h3> Antibiotic resistance ABC-Fs (ARE ABC-Fs) are translation factors currently proliferating among human pathogens that provide resistance against clinically important ribosome-targeting antibiotics. Here, we combine genetic and structural approaches to determine the activity of the <i>streptococcal</i> ARE ABC-F protein MsrD on the ribosome and its regulation in response to macrolide exposure. We show that cladinose-containing macrolides lead to insertion of MsrDL leader peptide into a conserved crevice of the ribosomal exit tunnel, which remained thus far undocumented, concomitantly with 23S rRNA rearrangements that preclude proper accommodation of release factors and inhibits termination. The stalled ribosome obstructs formation of a Rho-independent terminator which prevents <i>msrD</i> transcriptional attenuation. This stalled ribosome is rescued by MsrD powered by its two functionally asymmetric ATPase sites, but not by MsrD mutants which do not provide antibiotic resistance, showing evidence of equivalence between MsrD function in antibiotic resistance and its action on this complex.
Epithelial basement membrane of mouse jejunum. Evidence for laminin turnover along the entire crypt-villus axis.
Authors: J S Trier, C H Allan, D R Abrahamson, S J Hagen
Journal: Journal of Clinical Investigation (1990)

Little is known regarding turnover of the epithelial basement membrane in adult small intestine. Are components degraded and inserted along the length of the crypt-villus axis or selectively in the crypt region with subsequent migration of basement membrane from crypt to villus tip in concert with epithelium? We injected affinity-purified sheep anti-laminin IgG or sheep anti-laminin IgG complexed to horseradish peroxidase (HRP) into mice to label basement membrane laminin in vivo. Fluorescence microscopy revealed linear fluorescence along the length of the jejunal epithelial basement membrane 1 d after anti-laminin IgG injection. By 1 wk, small nonfluorescent domains were interposed between larger fluorescent domains. Over the next 5 wk the lengths of nonfluorescent domains increased progressively whereas those of fluorescent domains decreased. Additionally, electron microscopy revealed HRP reaction product along the length of the epithelial basement membrane after 1 d whereas unlabeled or lightly labeled domains that increased in length with time were observed interposed between heavily labeled domains by 2 and 4 wk along the entire crypt-villus axis. We conclude that laminin turnover occurs focally in the epithelial basement membrane of mouse jejunum along the crypt-villus axis over a period of weeks and that this basement membrane does not comigrate in concert with its overlying epithelium.
Silica exposure is associated with increased risk of developing rheumatoid arthritis: results from the Swedish EIRA study
Authors: Patrik Stolt, Henrik Källberg, Ingvar Lundberg, Bengt Sjögren, Lars Klareskog, Lars Alfredsson
Journal: Annals of the Rheumatic Diseases (2004)

Using a microbiological and a fluorimetric assay to determine penetration of erythromycin into vaginal fluids, concentrations were measured in plasma from nine men one hour after a single oral dose of erythromycin stearate 2 g and in vaginal washings and plasma samples taken simultaneously from 11 women two hours after the last dose of a 10-day course of erythromycin stearate (250 mg four times daily). Both assay methods gave accurate and reproducible results in plasma but only the fluorimetric method was capable of measuring concentrations of erythromycin in vaginal washings. The latter method had many advantages in estimating drug concentrations in body fluids such as vaginal washings and the results from it may provide an index of tissue penetration and of patient compliance in adhering to drug regimens.
Analysis of creatine kinase, CK-MB, myoglobin, and troponin T time-activity curves for early assessment of coronary artery reperfusion after intravenous thrombolysis.
Authors: M Zabel, S H Hohnloser, W Köster, M Prinz, W Kasper, H Just
Journal: Circulation (1993)

BACKGROUND Thrombolysis has become the standard therapeutic approach in patients with acute myocardial infarction. To identify patients who may benefit from early invasive procedures, reliable noninvasive assessment of success or failure of thrombolytic therapy is mandatory. METHODS AND RESULTS In a prospective study in 63 consecutive patients undergoing thrombolysis for their first myocardial infarction, serial measurements of creatine kinase (CK), its isoenzyme CK-MB, myoglobin, and troponin T were done to determine their value for noninvasive prediction of coronary artery patency. Blood samples were drawn every 15 minutes during the first 90 minutes, every 30 minutes during the first 4 hours, every 4 hours during the first 24 hours, and every 8 hours during the first 72 hours. The perfusion status of the infarct-related artery was assessed angiographically 90 minutes after initiation of thrombolysis. For each marker, time to its peak concentration and its early initial slope (start of thrombolysis to 90 minutes thereafter) were determined. Areas under receiver operator characteristic (ROC) curves were 0.83, 0.76, 0.82, and 0.80 for maxima of CK, CK-MB, myoglobin, and troponin T, respectively (p = NS by univariate Z test). The corresponding values for early slopes of CK, CK-MB, myoglobin, and troponin T were 0.79, 0.82, 0.89, and 0.80 (p = 0.23 for comparison between myoglobin and CK-MB; p = 0.07 between myoglobin and CK). Sensitivity, specificity, and positive and negative predictive values regarding noninvasive prediction of coronary artery patency after 90 minutes were 80%, 82%, 95%, and 61% for time to CK maximum; 91%, 77%, 91%, and 77% for time to myoglobin maximum; 87%, 71%, 89%, and 67% for early CK slope; and 94%, 88%, 94%, and 82% for myoglobin slope, respectively. When myoglobin slope was assessed together with other clinical reperfusion markers (resolution of chest pain or ST segment elevation, occurrence of reperfusion arrhythmias) by logistic regression analysis, only the myoglobin slope was an independent predictor of coronary artery patency (p &lt; 0.0001). CONCLUSIONS With regard to noninvasive prediction of coronary artery patency after thrombolytic therapy, measurement of the early initial slopes of the serum markers within only 90 minutes after the initiation of therapy is as accurate as the determination of the time to their peak concentration. Compared with the other markers examined, myoglobin appears to have advantages because of its earlier rise, yielding a better negative predictive value and a higher area under the ROC curve for determination of its early initial slopes.
Silvery-Gray Hair in a Newborn
Authors: Lawrence Wong, Shoji Yano
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
94 ADIPONECTIN-DEPENDENT ACTIVATION OF AMPK, BUT NOT OF PPARA, IS IMPLICATED IN THE PREVENTIVE EFFECT OF PIOGLITAZONE ON STEATOHEPATITIS
Authors: A. da Silva Morais, V. Lebrun, J. Abarca-Quinones, S. Brichard, L. Hue, B. Guigas, B. Viollet, I.A. Leclercq
Journal: Journal of Hepatology (2008)
Prognostic Importance of Emotional Support for Elderly Patients Hospitalized With Heart Failure
Authors: Harlan M. Krumholz, Javed Butler, Jeremy Miller, Viola Vaccarino, Christianna S. Williams, Carlos F. Mendes de Leon, Teresa E. Seeman, Stanislav V. Kasl, Lisa F. Berkman
Journal: Circulation (1998)

Background —Several studies have indicated that a variety of social relationships are important predictors of morbidity and mortality in patients with coronary artery disease, but little attention has been focused on the prognostic importance of these factors in the growing population of elderly patients with heart failure. To address this issue, we sought to determine whether emotional support is associated with fatal and nonfatal cardiovascular events in elderly patients hospitalized with heart failure. Methods and Results —We reviewed the medical records of 292 subjects aged ≥65 years who were hospitalized with clinical heart failure and were part of the New Haven, Conn, cohort of the Established Population for the Epidemiologic Study of the Elderly, a longitudinal, community-based study of aging that included a comprehensive assessment of psychosocial support. In the unadjusted analysis, lack of emotional support was significantly associated with the 1-year risk of fatal and nonfatal cardiovascular outcomes [odds ratio, 2.4; 95% confidence interval, 1.1 to 4.9]. After adjustment for demographic factors, clinical severity, comorbidity and functional status, social ties, and instrumental support, the absence of emotional support remained associated with a significantly higher risk (odds ratio, 3.2; 95% confidence interval, 1.4 to 7.8). The test for interaction between emotional support and sex was significant ( P =.01). In the fully adjusted model, the odds ratio for women was 8.2 (95% confidence interval, 2.5 to 27.2) compared with 1.0 (95% confidence interval, 0.3 to 3.3) for men. Conclusions —Among elderly patients hospitalized with clinical heart failure, the absence of emotional support, measured before admission, is a strong, independent predictor of the occurrence of fatal and nonfatal cardiovascular events in the year after admission. In this cohort, the association is restricted to women.
189 Hepatic inflammation increases portal pressure through inhibition of eNOS activity — Potential mechanisms
Authors: R.P. Mookerjee, N.A. Davies, S.J. Hodges, R.N. Dalton, C. Turner, A. Wiesenthal, K. Schilling, A. lcking, S. Sen, R. Williams, W. Muller-Esterl, R. Jalan
Journal: Journal of Hepatology (2006)
Iron deficiency anaemia: further education regarding the British Society of Gastroenterology guidelines is required
Authors: K. Gregory, M. Halliday, C. Averill, N. Bhala, C. Tselepis, T. Iqbal
Journal: Gut (2007)

The publication of the iron deficiency guidelines in 20051 and the adoption of iron deficiency anaemia (IDA) as a 2-week referral criterion by the National Institute for Clinical Excellence lower gastrointestinal (GI) cancer guidelines2 should have focused attention on this historically poorly managed condition. There is evidence from the primary care literature of poor adherence to previous IDA guidelines.3 In order to evaulate adherence to the new IDA guidelines in our trust, we undertook a short prospective audit of all patients admitted in 1 month through …
Bisphenol A is released from used polycarbonate animal cages into water at room temperature.
Authors: Kembra L Howdeshell, Paul H Peterman, Barbara M Judy, Julia A Taylor, Carl E Orazio, Rachel L Ruhlen, Frederick S Vom Saal, Wade V Welshons
Journal: Environmental Health Perspectives (2003)

Bisphenol A (BPA) is a monomer with estrogenic activity that is used in the production of food packaging, dental sealants, polycarbonate plastic, and many other products. The monomer has previously been reported to hydrolyze and leach from these products under high heat and alkaline conditions, and the amount of leaching increases as a function of use. We examined whether new and used polycarbonate animal cages passively release bioactive levels of BPA into water at room temperature and neutral pH. Purified water was incubated at room temperature in new polycarbonate and polysulfone cages and used (discolored) polycarbonate cages, as well as control (glass and used polypropylene) containers. The resulting water samples were characterized with gas chromatography/mass spectrometry (GC/MS) and tested for estrogenic activity using an MCF-7 human breast cancer cell proliferation assay. Significant estrogenic activity, identifiable as BPA by GC/MS (up to 310 micro g/L), was released from used polycarbonate animal cages. Detectable levels of BPA were released from new polycarbonate cages (up to 0.3 micro g/L) as well as new polysulfone cages (1.5 micro g/L), whereas no BPA was detected in water incubated in glass and used polypropylene cages. Finally, BPA exposure as a result of being housed in used polycarbonate cages produced a 16% increase in uterine weight in prepubertal female mice relative to females housed in used polypropylene cages, although the difference was not statistically significant. Our findings suggest that laboratory animals maintained in polycarbonate and polysulfone cages are exposed to BPA via leaching, with exposure reaching the highest levels in old cages.
Functional Closure of the Ventricular Septal Defect After Pulmonary Artery Banding
Authors: Keshava Murthy
Journal: JAMA (1968)

A 9-week-old infant with a large ventricular septal defect (VSD) underwent successful banding of the pulmonary artery with clinical improvement. Spontaneous functional closure of the VSD later developed and, at age 4 1/2 years, the clinical and hemodynamic findings were those of severe isolated pulmonary stenosis with right ventricular failure. Severe right ventricular hypertrophy appearing late in the postoperative period should alert one of the possibility of a spontaneously closing VSD.
Relapse after Standard Treatment of Malaria
Authors: R. A. Wiseman
Journal: BMJ (1970)

already a minimum age-limit for the pur- chase of tobacco.But there is nothing what- soever to stop children from buying their cigarettes from automatic machines which are to be found in abundance.If the Government is serious in its wish to deter people from smoking, it would be a very simple measure to ban cigarette machines completely.Such a move would have the virtue of harming nobody (except the manufacturers of cigarettes and automatic machines) while producing the maxi- mum potential benefits.-Iam, etc.,
Inhibition of VEGF receptors causes lung cell apoptosis and emphysema
Authors: Yasunori Kasahara, Rubin M. Tuder, Laimute Taraseviciene-Stewart, Timothy D. Le Cras, Steven Abman, Peter K. Hirth, Johannes Waltenberger, Norbert F. Voelkel
Journal: Journal of Clinical Investigation (2000)

Pulmonary emphysema, a significant global health problem, is characterized by a loss of alveolar structures. Because VEGF is a trophic factor required for the survival of endothelial cells and is abundantly expressed in the lung, we hypothesized that chronic blockade of VEGF receptors could induce alveolar cell apoptosis and emphysema. Chronic treatment of rats with the VEGF receptor blocker SU5416 led to enlargement of the air spaces, indicative of emphysema. The VEGF receptor inhibitor SU5416 induced alveolar septal cell apoptosis but did not inhibit lung cell proliferation. Viewed by angiography, SU5416-treated rat lungs showed a pruning of the pulmonary arterial tree, although we observed no lung infiltration by inflammatory cells or fibrosis. SU5416 treatment led to a decrease in lung expression of VEGF receptor 2 (VEGFR-2), phosphorylated VEGFR-2, and Akt-1 in the complex with VEGFR-2. Treatment with the caspase inhibitor Z-Asp-CH2-DCB prevented SU5416-induced septal cell apoptosis and emphysema development. These findings suggest that VEGF receptor signaling is required for maintenance of the alveolar structures and, further, that alveolar septal cell apoptosis contributes to the pathogenesis of emphysema.
An Inflammatory Lesion in an HIV-Positive Bleeder Detected by Tc-99m Labeled Antigranulocyte Antibodies
Authors: C MENZEL, F GR??NWALD, N HOLZKNECHT, A L HOTZE, H J BIERSACK
Journal: Clinical Nuclear Medicine (1994)

A case of an HIV-positive bleeder with fever and a pseudotumor in the left gluteal region, suspected to be due to result hemophilic bleeding, is presented. Native CT imaging revealed a tumor in the left psoas region, destructing the ala of the ilium and infiltrating the left gluteal region. Planar scintigraphy using Tc-99m labeled antigranulocyte antibodies (BW 250/183) showed a diffuse tracer accumulation in projection to the left gluteal region and the left psoas region, descending to the inguinal ligament. SPECT studies revealed a pathologic tracer accumulation in the regions revealed by CT, proving the pseudotumor to be an abscess. Surgical intervention finally revealed a 500 mL, salmonella-positive abscess that was drained.