tbuckley/cabot-search huggingface dataset:
Cutaneous vascular ectasia treated by non-laser infra-red
Authors: G.B. Colver, R.L. Jones, G.W. Chbrry, R.P.R. Dawber, T.J. Ryan
Journal: British Journal of Dermatology (1985)

Journal Article Cutaneous vascular ectasia treated by non‐laser infra‐red Get access G.B. Colver, G.B. Colver Department of Dermatology, Slade Hospital, Oxford Search for other works by this author on: Oxford Academic Google Scholar R.L. Jones, R.L. Jones Department of Dermatology, Slade Hospital, Oxford Search for other works by this author on: Oxford Academic Google Scholar G.W. Chbrry, G.W. Chbrry Department of Dermatology, Slade Hospital, Oxford Search for other works by this author on: Oxford Academic Google Scholar R.P.R. Dawber, R.P.R. Dawber Department of Dermatology, Slade Hospital, Oxford Search for other works by this author on: Oxford Academic Google Scholar T.J. Ryan T.J. Ryan Department of Dermatology, Slade Hospital, Oxford Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 113, Issue s29, 1 July 1985, Page 30, https://doi.org/10.1111/j.1365-2133.1985.tb12990.x Published: 01 July 1985
Hypoxaemia after left thoracotomy for benign oesophageal disease.
Authors: E T Bainbridge, H R Matthews
Journal: Thorax (1980)

Arterial blood gases were measured before and after operation in 14 patients undergoing conservative oesophageal surgery via a left thoracotomy. All the patients had a preoperative partial pressure of oxygen (PO2) of greater than 10 kPa, and none gave a history of chronic respiratory disease. All exhibited a fall in PO2 values after operation, the mean maximum reduction being 31%. The overall pattern of hhypoxaemia was similar to that previously reported after pulmonary resection, and upper abdominal surgery, characterised by the greatest reduction in PO2 on the first two postoperative days, followed by a gradual return towards preoperative values. In addition, there was a marked similarity in the degree of hypoxaemia observed by Parfey et al and by ourselves. These findings are attributed to similar changes occurring in pulmonary function in both series of patients, caused at least in part by different factors associated specifically with the two surgical approaches involved. In our experience, left thoracotomy, even without pulmonary resection, is associated with significant postoperative hypoxaemia. Knowledge of this may assist in the selection of patients for surgery and in their subsequent management.
Cancer Surveillance Series: Recent Trends in Childhood Cancer Incidence and Mortality in the United States
Authors: M. S. Linet, L. A. G. Ries, M. A. Smith, R. E. Tarone, S. S. Devesa
Journal: JNCI Journal of the National Cancer Institute (1999)

Public concern about possible increases in childhood cancer incidence in the United States led us to examine recent incidence and mortality patterns.Cancers diagnosed in 14540 children under age 15 years from 1975 through 1995 and reported to nine population-based registries in the National Cancer Institute's Surveillance, Epidemiology, and End Results Program were investigated. Age-adjusted incidence was analyzed according to anatomic site and histologic categories of the International Classification of Childhood Cancer. Age-adjusted U.S. mortality rates were calculated. Trends in rates were evaluated by use of standard regression methods.A modest rise in the incidence of leukemia, the most common childhood cancer, was largely due to an abrupt increase from 1983 to 1984; rates have decreased slightly since 1989. For brain and other central nervous system (CNS) cancers, incidence rose modestly, although statistically significantly (two-sided P = .020), largely from 1983 through 1986. A few rare childhood cancers demonstrated upward trends (e.g., the 40% of skin cancers designated as dermatofibrosarcomas, adrenal neuroblastomas, and retinoblastomas, the latter two in infants only). In contrast, incidence decreased modestly but statistically significantly for Hodgkin's disease (two-sided P = .037). Mortality rates declined steadily for all major childhood cancer categories, although less rapidly for brain/CNS cancers.There was no substantial change in incidence for the major pediatric cancers, and rates have remained relatively stable since the mid-1980s. The modest increases that were observed for brain/CNS cancers, leukemia, and infant neuroblastoma were confined to the mid-1980s. The patterns suggest that the increases likely reflected diagnostic improvements or reporting changes. Dramatic declines in childhood cancer mortality represent treatment-related improvements in survival.
Third Case of Chronic Lymphocytic Leukaemia in a Carrier of the Inherited Ch1 Chromosome
Authors: P. H. Fitzgerald, J. W. Hamer
Journal: BMJ (1969)

Chronic lymphocytic leukaemia has developed in three siblings who are all carriers of the abnormal Ch<sup>1</sup> chromosome. <sup>3</sup>H-thymidine autoradiography showed Ch<sup>1</sup> to be a G<sub>2</sub> autosome, from which the short arm is absent, and not G<sub>1</sub>, which is trisomic in Down9s syndrome and which is believed to form the abnormal Ph<sup>1</sup> chromosome. Ch<sup>1</sup> is not of general significance in the aetiology of chronic lymphocytic leukaemia, but it must be considered as a possible predisposing factor to leukaemia in the present family.
Treatment of Shock and Prevention of Ischemic Necrosis with Levarterenol-Phentolamine Mixtures
Authors: GARY ZUCKER, ROBERT P. EISINGER, MARTIN H. FLOCH, MARK M. SINGER
Journal: Circulation (1960)

Good pressor responses were obtained in 51 of 68 cases of shock treated with levarterenol-phentolamine mixtures. No necrosis developed in 33 extravasations of mixtures. One slough resulted from an extravasation of 8 mg./L. of levarterenol alone. Our present practice is to add 5 mg. of phentolamine to each liter of levarterenol solution.
ROSE system for treatment of cholera dehydration.
Authors: M Gracey, None Suharjono, S W Adnan, None Sutejo
Journal: BMJ (1977)

with tritiated thymidine.Thrombosed vessels were occasionally seen in the bases of the oesopha- geal ulcers, with gross epithelial hyperplasia and numerous mitotic figures which were distin- guishable from carcinomas only by the absence of muscular invasion of the disorganised epithelial overgrowth.Most of these lesions cleared with parenteral riboflavin.'Despite these widespread and severe changes in the squamous epithelium, ocular and respiratory abnormalities such as are found in vitamin A deficiency were not seen.There were considerable resemblances between these lesions and those produced in the skin of mice by painting with carcinogens.3Wynder4 and Warburg5 commented on the similarities between the oesophageal lesions in riboflavin-deficient mice and the precancerous oral and oesophageal changes in the Plummer- Vincent syndrome.In all the B,-deprived baboons there was intense adrenal cortical fibrosis and changes in 11-and 17-hydroxycorticosteroids and 17- oxosteroids before and after corticotrophin stimulation6 as well as changes in the serum protein pattern and tryptophan metabolism.There were no significant changes in liver histology such as occurs in pyridoxinedeprived baboons.2There is some evidence that analogues ofvitamin B2, like galactoflavine, produce side effects over and above those associated with deficiency of vitamin B2 only, and these effects should be considered in any experiments involving the use of vitamin analogues.We think then that riboflavin deficiency has an important place in the development of squamous epithelial derangements.
Prediction of the Relative Blood Glucose Response of Mixed Meals Using the White Bread Glycemic Index
Authors: Thomas M Wolever, Frank Q Nuttall, Randolph Lee, Gerald S Wong, Robert G Josse, Adele Csima, David J Jenkins
Journal: Diabetes Care (1985)

Unexpected plasma glucose responses to different mixed meals fed to normal and diabetic volunteers have recently been reported. We have therefore examined in normal volunteers the effect of mixing carbohydrate foods of different glycemic indices (GIs) without the addition of fat and protein. The observed GI of the mixed meal was within 2% of the expected value. In studies in the literature where fat and protein were added to mixed meals, the observed blood glucose responses also related significantly to the meal GIs calculated from the individual foods. Addition of fat and protein in the quantities used did not obscure this relationship. Studies to determine sources of error in comparing glycemic responses showed that type II diabetic patients displayed the least within-individual variation, and type I diabetic patients the most. Expression of results as the GI rather than as absolute glycemic response areas reduced by 50% the between-subject variation. The mean GI values of rice tested in type I and type II patients were similar (82 ± 22 compared with 74 ± 19) and the reproducibility 22 mo later in the same group of subjects was excellent (81 ± 15 compared with 83 ± 15). However, the lack of precise GI values for all foods fed in the test meals indicates a need for GI values to be derived for a wider range of individual foodstuffs. The GI approach to classifying foods according to physiologic effect may play a useful role in planning meals and diets in which specific blood glucose profiles are required.
Chlorpromazine-induced vanishing bile duct syndrome leading to biliary cirrhosis
Authors: Darius Moradpour, Josef Altorfer, Renata Flury, Peter Greminger, Christa Meyenberger, Res Jost, Martin Schmid
Journal: Hepatology (1994)

We describe a 33-yr-old pregnant woman in whom a primary biliary cirrhosis—like syndrome developed after 2 wk of chlorpromazine therapy. The clinical course was characterized by severe jaundice lasting 22 mo, intense pruritus, fever, steatorrhea, high alkaline phosphatase levels and hypercholesterolemia. Jaundice resolved with initiation of ursodeoxycholic acid therapy, but subclinical cholestasis and low-level inflammatory activity persisted and ultimately evolved into biliary cirrhosis. The pathological substrate of this severe and prolonged cholestatic reaction was found to be the vanishing bile duct syndrome with a marked transient pseudoxanthomatosis. (Hepatology 1994;20:1437-1441).
Liver Biopsy and Radioisotope Scans
Authors: Sheldon Baum
Journal: JAMA (1968)

<h3>To the Editor:—</h3> In their article on percutaneous liver biopsy (<b>202</b>:53, 1967), Wilber and Foulk state that the value of hepatic scintillography in "accurately delineating the site for hepatic needle biopsy in neoplastic liver lesions is not yet proved." It is our feeling that the identification of a space-occupying lesion on a radioisotope liver scan may offer some assistance in locating a specific area for biopsy. A liver scan performed after the intravenous administration of 200μc of colloidal gold Au 198 is illustrated in Fig 1. It shows several metastatic lesions. With the scan as a guide, the borders of the liver and one of the space-occupying lesions are outlined on the patient's skin (Fig 2). Since the scan is a life-size representation of the organ without distortion, the borders so outlined indicate the projections of both the liver and metastatic lesion on the skin surface. Employing this method,
The SUPPORT Project and Improving Care for Seriously III Patients
Authors: Mark S. Godec
Journal: JAMA (1996)

<h3>To the Editor.</h3> — The article by the SUPPORT investigators<sup>1</sup>is an outstanding and comprehensive study of the US medical system's treatment of dying patients. Unfortunately, the data the authors present are a terrible indictment of physicians and our medical system. This study clearly demonstrates the failure of the US medical system to deal rationally and humanely with dying patients and provides evidence of the enormous medical and financial resources consumed by futile medical care. The SUPPORT project sought to understand and to improve medical treatment of dying patients by facilitating communication between physicians, patients, and families. This is a logical first step in reducing patient suffering and unwanted prolongation of life by heroic measures. However, the study's failure to improve care or alter outcome for dying patients shows that more powerful forces exist in our health care system that drive futile care. Large monetary rewards are available to
WHO to strengthen commitment to polio eradication
Authors: Dinesh C Sharma
Journal: The Lancet (2003)

WHO Director-General Jong-wook Lee announced on July 29 that the agency will step up the global effort to eradicate polio. He has named David Heymann —who led the WHO effort to halt the severe acute respiratory syndrome (SARS) outbreak—as the Representative of the Director-General for Polio Eradication.
A radioimmunoassay procedure for type III procollagen: Its use in the detection of hepatic fibrosis
Authors: Michael R. Galambos, Delwood C. Collins, John T. Galambos
Journal: Hepatology (1985)

Recent studies suggest that the serum level of Type III procollagen (PC–III) could be a valuable, noninvasive monitor of hepatic fibrogenesis. We have developed a sensitive and specific radioimmunoassay for PC–III procollagen isolated and purified from fetal goat skin which shows high cross–reaction for human PC–III. In a double–blind study, serum samples taken from 8 normal volunteers and 50 patients at the time of liver biopsy were assayed for PC–III. Each biopsy was reviewed without knowledge of the radioimmunoassay results, and old or active fibrosis was graded on a 0 to 3 (none, minimal, moderate, severe) scale. There was a significant difference between serum concentrations of PC–III in normals (mean ± S.D. = 72 ng per ml ± 8) as compared to patients with biopsy evidence of active fibrosis (mean ± S.D. = 153 ng per ml ± 12; p &lt; 0.001). The serum concentration of PC–III showed a good correlation (r = 0.58; p &lt; 0.001) with the histological grade of active lobular fibrosis. Measurement of PC–III is a noninvasive test for detection of active fibrosis in the liver.
The Psychiatric Therapies
Authors: Carl C. Bell
Journal: JAMA (1985)

The prospect of reading a 932-page book on the various types of psychiatric therapies may be an unpleasant one for busy professionals. However, the succinct, terse style of this text makes the endeavor a quick and agreeable one. The major strength of the book is that the contributors of the various chapters on the psychiatric therapies are deservedly thought of as experts on the subjects they address, and the overviews given by them on their areas of expertise are informative, relevant, and comprehensive. The material on the psychiatric therapies is well distilled, resulting in a concentrated overview that would be helpful for students and trainees preparing for examinations but that is also comprehensive enough to serve as a primary textbook for the initial study of the psychiatric therapies. A major advantage is that one can begin to study the various forms of therapies using only one well-written book to get
Update on Parkinson Disease
Authors: Andrew Siderowf, Matthew Stern
Journal: Annals of Internal Medicine (2003)

This Update reviews developments in the pathophysiology and treatment of Parkinson disease during the past several years. In the area of pathophysiology, studies have addressed the contribution of environmental factors such as caffeine and pesticides. Large-scale epidemiologic studies have also expanded the role genetic factors are thought to play. Detailed studies of kindreds with familial Parkinson disease due to alpha-synuclein and parkin have catalyzed basic science investigations into the pathologic mechanisms of the disease. These studies have led to the development of a pathophysiologic model of Parkinson disease that emphasizes abnormal protein aggregation. Studies of treatment have clarified the relative roles of l-dopa and dopamine agonists in early Parkinson disease and shown the potential for surgical interventions, particularly deep-brain stimulation, to relieve the symptoms of advanced, medically refractory disease.
RETICULAR KERATITIS: REPORT OF A CASE
Authors: Elton S. Osborne
Journal: JAMA (1923)

In the case here reported, the malarial parasite appears to be the etiologic factor. A young man, seen in November, who had been working at his trade as a carpenter for several months in various small towns situated near the Savannah River swamps, a malarial section, had had chills and fever, in September, for which he took quinin. Whenever treatment was stopped, the symptoms reappeared, this continuing for two months. Two days before I saw him, he was driving an automobile in the country, and he thought a foreign body had entered the left eye, which suddenly became painful and inflamed, rendering sleep impossible. Examination revealed the conjunctiva of the left eye inflamed, and there was pericorneal injection. There were raised ridges on the corneal surface, having the shape shown in the illustration, the epithelium of which was raised above the corneal level; but there was no denuding of the
GASTROJEJUNOSTOMY WITH THE McGRAW ELASTIC LIGATURE, FOR THE RELIEF OF GASTROPTOSIS.
Authors: H. O. WALKER
Journal: JAMA (1903)

If, as Meinert asserts, 90 per cent. of all women have gastroptosis, and knowing as we do the inefficiency of mechanical and medicinal treatment of this distressing malady in a great number of cases, one may be pardoned for presenting a method that offers features of benefit, whether it is mechanical, medicinal or surgical. Surgically, little has been done, and that but recently, in the way of improvement of; this condition. Gastroplication and gastrorrhaphy are the principal procedures, and have not been attended with very brilliant results, as they do not always relieve the chronic pyloric kinking, and although I may not be presenting anything new, yet, as far as I know, except by allusion, nothing has been presented along the lines that I offer. With this brief introduction I beg leave to make a somewhat detailed report of three cases in which a gastrojejunostomy was done for the relief
Naturally processed T cell epitopes from human glutamic acid decarboxylase identified using mice transgenic for the type 1 diabetes-associated human MHC class II allele, DRB1*0401.
Authors: L S Wicker, S L Chen, G T Nepom, J F Elliott, D C Freed, A Bansal, S Zheng, A Herman, A Lernmark, D M Zaller, L B Peterson, J B Rothbard, R Cummings, P J Whiteley
Journal: Journal of Clinical Investigation (1996)

The identification of class II binding peptide epitopes from autoimmune disease-related antigens is an essential step in the development of antigen-specific immune modulation therapy. In the case of type 1 diabetes, T cell and B cell reactivity to the autoantigen glutamic acid decarboxylase 65 (GAD65) is associated with disease development in humans and in nonobese diabetic (NOD) mice. In this study, we identify two DRB1*0401-restricted T cell epitopes from human GAD65, 274-286, and 115-127. Both peptides are immunogenic in transgenic mice expressing functional DRB1*0401 MHC class II molecules but not in nontransgenic littermates. Processing of GAD65 by antigen presenting cells (APC) resulted in the formation of DRB1*0401 complexes loaded with either the 274-286 or 115-127 epitopes, suggesting that these naturally derived epitopes may be displayed on APC recruited into pancreatic islets. The presentation of these two T cell epitopes in the islets of DRB1*0401 individuals who are at risk for type 1 diabetes may allow for antigen-specific recruitment of regulatory cells to the islets following peptide immunization.
IDIOSYNCRASY TO SALYRGAN
Authors: I. J. Wolf
Journal: JAMA (1934)

To the Editor:—  I have read with interest Dr. Carter Smith's report on the use of salyrgan in one patient over a period of three years (The Journal, February 17, p. 532). He states that only one instance of idiosyncrasy to salyrgan has been reported in the literature, that by Andrews in the Lancet , July 18, 1931. I wish to point out that Dr. Bongiorno and I reported a case of sudden death due to salyrgan in a nephrotic child, aged 4, in the Canadian Medical Journal ( 25 :73 [July] 1931). The injection preceding the fatal one caused a chill, fever, a morbilliform rash, anorexia and malaise. Good diuresis was obtained, whereas previous injections failed to provoke a satisfactory response. A week later the sixth and fatal dose was given, causing sudden death, which was anaphylactic in nature.
Cigarette Smoking and Exposure to Passive Smoke Are Risk Factors for Cervical Cancer
Authors: Martha L. Slattery, Linda M. Robison, Katharina L. Schuman, Thomas K. French, Thomas M. Abbott, James C. Overall, John W. Gardner
Journal: JAMA (1989)

Personal cigarette smoking and exposure to passive smoke as risk factors for cervical cancer were examined in a population-based, case-control study conducted in Utah. Personal cigarette smoking was found to increase the risk of cervical cancer, after adjusting for age, educational level, church attendance, and sexual activity. The adjusted risk estimate associated with being a current smoker was 3.42 (95% confidence interval [Cl], 2.10 to 5.57); for having smoked for 5 or more pack-years, it was 2.81 (95% Cl, 1.73 to 4.55); and for having smoked at least 100 lifetime cigarettes, it was 2.21 (95% Cl, 1.44 to 3.39). The adjusted risk estimate (also adjusted for actual cigarettes smoked) associated with passive smoke exposure for 3 or more hours per day was 2.96 (95% Cl, 1.25 to 7.03). Risk from passive smoking was greater in women who were not smokers (odds ratio, 3.43; 95% Cl, 1.23 to 9.54) than in women who smoked (odds ratio, 2.59; 95% Cl, 0.23 to 29.24).
Intractable Anemias: Recognition and Therapeutic Approach.
Authors: F. H. Gardner
Journal: Annals of Internal Medicine (1962)

s1 April 1962Intractable Anemias: Recognition and Therapeutic Approach.F. H. Gardner, M.D., F.A.C.P.F. H. Gardner, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-56-4-685_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe physician in past years has been faced with a variety of anemias that have given no evidence of response to the usual nutritional hematinic agents. In some instances, iron loss from the gastrointestinal tract has presented a difficult problem in achieving adequate replacement to sustain erythropoiesis by the usual methods available. The value of careful use of intravenous iron preparations is discussed. Splenectomy has been helpful in alleviating anemias associated with bone marrow hypoplasia and hemolysis and should continue to receive consideration after prolonged therapy. The value of three non-nutritional agents, cobalt, corticoids, and androgens should be considered more... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: F. H. Gardner, M.D., F.A.C.P.Affiliations: Boston, Mass. (ML) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1962Volume 56, Issue 4 Page: 685-685 Keywords Androgens Anemia Bone marrow Erythropoiesis Gastrointestinal tract Nutrition Splenectomy ePublished: 1 December 2008 Issue Published: 1 April 1962 PDF downloadLoading ...