tbuckley/cabot-search huggingface dataset:
TRUST AND ALLIANCE
Authors: George Brinnig Jastrzebski
Journal: Annals of Internal Medicine (1989)

Ad Libitum15 January 1989TRUST AND ALLIANCEGeorge Brinnig Jastrzebski, PhD, MDGeorge Brinnig Jastrzebski, PhD, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-110-2-173_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAs Doctor of Medicine I will serve from this day,with human art and imperfect science.Alleviate our suffering and pain as you may.Enhance our health and self-reliance.I serve in my calling without concernfor origin, race, religion, or wealth.We share in your effort to practice and learnwhat we may do to nurture health.I regard life as sacred. Its dignity I defend.My patient's will I uphold and respect.Explain our choices so that we may comprehend,and be wise in the decisions that we elect.I will base my treatments on the proper evidence,... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: George Brinnig Jastrzebski, PhD, MDAffiliations: San Francisco, California PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 January 1989Volume 110, Issue 2Page: 173-173KeywordsRacial and ethnic issues ePublished: 1 December 2008 Issue Published: 15 January 1989 Copyright & Permissions©1989 American College of PhysiciansPDF downloadLoading ...
Effect of interleukin-6 polymorphisms on human longevity: A systematic review and meta-analysis
Authors: Danilo Di Bona, Sonya Vasto, Cristiano Capurso, Lene Christiansen, Luca Deiana, Claudio Franceschi, Mikko Hurme, Eugenio Mocchegiani, Maeve Rea, Domenico Lio, Giuseppina Candore, Calogero Caruso
Journal: Ageing Research Reviews (2008)
A new model of patient privacy?
Authors: Clare Dyer
Journal: BMJ (2004)

In January 1990 the television actor Gorden Kaye, star of 'Allo 'Allo , was driving in a gale when a piece of wood smashed through his windscreen. He sustained severe head injuries, spending three days on a life support machine.

Kaye was just out of intensive care and lying heavily sedated in a private room when a reporter and photographer from the tabloid Sunday Sport sneaked in, ignoring a notice banning unauthorised visitors. The still-confused actor told the reporter about the incident and the photographer snapped pictures till nurses ejected the pair.

The actor's agent tried to stop the paper publishing the interview. But there was no right to privacy in English law and the courts found themselves powerless. The most they could do was insist that the paper make it clear that the story had been published without Kaye's consent.

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Supermodel Naomi Campbell: legal victory 

Credit: MICHAEL LLOYD/REX FEATURES

Much judicial handwringing followed as commentators suggested that the judges should have been bolder and more inventive. Fast forward to 1998 and the enactment of the Human Rights Act, making the European …

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Thyroidal Uptake of lodine-123 in Children Using a Gamma Camera and Computer
Authors: SYDNEY HEYMAN
Journal: Clinical Nuclear Medicine (1985)

The measurement of thyroidal uptake of radioiodine using a gamma camera and computer is described. In 12 children there was good agreement with simultaneous measurements using a probe, while in a further 14 patients the uptake values were consistent with the clinical diagnosis. The technique should be especially useful for infants and small children.
Shall we "reproduce"? II. Rejoinders and future forecast
Authors: P. Ramsey
Journal: JAMA (1972)

In the previous issue ofThe Journal<sup>1</sup>I set forth the ethical objections against in vitro fertilization and embryo transplantation which can be drawn from applying to these experiments the received standards of medical ethics. Unless the ethics of the medical research profession is to be radically revised or abandoned, we ought not to manipulate at risk the child-to-be. I now want to take up certain answers to my argument. From the nature of these rejoinders we can clearly see the extent to which human procreation has already been replaced by the idea of "manufacturing" our progeny. Unless and until<i>that</i>concept is reversed, mankind's movement toward Aldous Huxley's Hatcheries must surely prove irreversible. It may be granted that the mimicry of natural fertilization, implantation, and the environment of the womb cannot be guaranteed to be perfect or without possibly harmful, induced impairments to the possible future child. It
Of metals, mice, and men: what animal models can teach us about body iron loading
Authors: Gregory J. Anderson, Lawrie W. Powell
Journal: Journal of Clinical Investigation (2000)

Hemochromatosis is a common inherited disease of iron overload that results from mutations in the HFE gene (1).It has long been known that basic processes of body iron homeostasis, and in particular intestinal iron absorption, are regulated aberrantly in hemochromatosis, so an understanding of how HFE functions in cellular and body iron homeostasis may hold the key to dissecting these essential physiological processes.However, despite a growing body of elegant experimentation, the recalcitrant HFE molecule has yet to reveal all its secrets.The clinical features of hemochromatosis are almost exclusively due to increased iron storage in the parenchymal cells of many tissues, particularly
Learning and exploration: Lessons from infants
Authors: Karen E. Adolph, Ludovic M. Marin, Frederic F. Fraisse
Journal: Behavioral and Brain Sciences (2001)

Based on studies with infants, we expand on Stoffregen & Bardy's explanation of perceptual motor errors, given the global array. Information pick-up from the global array is not sufficient without adequate exploratory movements and learning to support perceptually guided activity.
Peripheral gangrene in infancy and childhood.
Authors: A. Lloyd, M. Kemball, G. Fraser
Journal: BMJ (1967)

A 5-month-old infant with symmetrical gangrene of the extremities was recently admitted to the Hospital for Sick Children.This condition is now rare in the paediatric age group, and only three other children with similar features have been seen at this hospital in the past 15 years.Peripheral vascular obstruction due to primary arterial disease would appear to be a significant cause of limb gangrene in childhood, as illustrated by the following case reports.Case 1This infant, a male, was born on 1 January 1965 after a normal pregnancy and delivery.His parents and elder brother were healthy.He was well until the age of 5 months, when he developed a transient morbilliform rash on the limbs, followed by a febrile illness which was associated with extreme pallor and coldness of all four extremities.Within two days the right hand and forearm had become gangrenous, with a sloughing ulcer on the flexor aspect of the wrist.He was first seen at this hospital on the third day of his illness, when he looked pale and ill, and had a faint, blotchy rash over the upper abdomen and chest.In addition to the gangrene of the right arm the other limbs were cold, with colour changes varying from pallor to cyanosis.Both axillary and femoral pulses were present, but no distal pulses were palpable.The blood pressure was unobtainable except in the right leg, where it was 130/95 mm.Hg.Physical examination was otherwise normal.Laboratory Investigations.-Hb 7.8 g./100 ml.(54%); W.B.C.54,000/ cu.mm.(polymorphonuclear cells 80%); E.S.R. 59 mm./ hour.Serum gammaglobulins: gamma G 640 mg./100 ml., gamma M 175 % of standard normal serum, gamma A 31% of standard normal serum.Sheep-cell agglutination: titre of 1 in 8. Blood cultures: no growth obtained from three specimens.E.C.G.: left ventricular hypertrophy.Chest x-ray examination: heart size normal, lungs clear.C.S.F.: protein 15 mg./100 ml., sugar 72 mg., culture sterile.Urine: normal microscopy and culture.Urine chromatography: lactose 200 mg./100ml., sucrose 200 mg./100ml.; raised excretion of tyrosine, phenylalanine, glutamine, threo- nine, serine, alanine.Other investigations, which included lupus erythematosus preparations, Wassermann reactions, cold agglutinins, macroglobulins, and heavy-metal estimations, were all negative. TreatmentInitially he received a transfusion of 210 ml. of whole blood, and treatment was started with prednisone 40 mg./day.Antibiotic cover was provided with cloxacillin 500 mg.and ampicillin 250 mg.daily.In order to improve the peripheral circulation he was given 240 ml. of rheomacrodex intravenously, but in spite of this the changes in the left foot progressed to gangrene.An effort to halt this process by means of hyperbaric oxygen was then made.'During the next five days he received a total of 40 hours' com- pression at two and a half atmospheres, this being given for periods of two hours at a time.During treatment in the oxygen chamber striking colour changes occurred in the limbs, the cyanosis being
General Practice--at Home, and Abroad
Authors: W. MacBride
Journal: BMJ (1965)

American surgeon and his family on three months' " holiday."Although he worked as hard as the rest of us, he thoroughly enjoyed the change of surroundings and the stimulus of new problems which he found, and he insisted that it was worth every dollar he had spent.When he worked out the cost, he discovered that it was equivalent to the price of a new Cadillac.I doubt if it can always be done for that price, but if we can persuade some British doctors to do likewise their contribution towards meeting Africa's need would be worth incalculably more than the cost of a new Rolls.Those of us working in Africa are constantly aware of the danger of our medicine becoming rusty.This has to be balanced against what we are actually achieving.It seems precious little at times in the chaos of trying to be all things to all patients.These things cannot be measured in academic terms, but short-term working visits by sympathetic doctors from "overdeveloped " countries would do a great deal to revive our drooping spirits and keep alight the flickering academic light.Just to have someone with whom to talk shop means more than will be appreciated by those plagued with a surfeit of medical meetings.-Iam, etc.,
Pilot Study of Extracorporeal Removal of Soluble Fms-Like Tyrosine Kinase 1 in Preeclampsia
Authors: Ravi Thadhani, Tuelay Kisner, Henning Hagmann, Verena Bossung, Stefanie Noack, Wiebke Schaarschmidt, Alexander Jank, Angela Kribs, Oliver A. Cornely, Claudia Kreyssig, Linda Hemphill, Alan C. Rigby, Santosh Khedkar, Tom H. Lindner, Peter Mallmann, Holger Stepan, S. Ananth Karumanchi, Thomas Benzing
Journal: Circulation (2011)

Background— Targeted therapies to stabilize the clinical manifestations and prolong pregnancy in preeclampsia do not exist. Soluble fms-like tyrosine kinase 1 (sFlt-1), an alternatively spliced variant of the vascular endothelial growth factor receptor 1, induces a preeclampsia-like phenotype in experimental models and circulates at elevated levels in human preeclampsia. Removing sFlt-1 may benefit women with very preterm (&lt;32 weeks) preeclampsia. Methods and Results— We first show that negatively charged dextran sulfate cellulose columns adsorb sFlt-1 in vitro. In 5 women with very preterm preeclampsia and elevated circulating sFlt-1 levels, we next demonstrate that a single dextran sulfate cellulose apheresis treatment reduces circulating sFlt-1 levels in a dose-dependent fashion. Finally, we performed multiple apheresis treatments in 3 additional women with very preterm (gestational age at admission 28, 30, and 27+4 weeks) preeclampsia and elevated circulating sFlt-1 levels. Dextran sulfate apheresis lowered circulating sFlt-1, reduced proteinuria, and stabilized blood pressure without apparent adverse events to mother and fetus. Pregnancy lasted for 15 and 19 days in women treated twice and 23 days in a woman treated 4 times. In each, there was evidence of fetal growth. Conclusions— This pilot study supports the hypothesis that extracorporeal apheresis can lower circulating sFlt-1 in very preterm preeclampsia. Further studies are warranted to determine whether this intervention safely and effectively prolongs pregnancy and improves maternal and fetal outcomes in this setting.
Phase II study of theophylline in chronic lymphocytic leukemia: a study of the Eastern Cooperative Oncology Group (E4998)
Authors: P H Wiernik, E Paietta, O Goloubeva, S J Lee, D Makower, J M Bennett, J L Wade, C Ghosh, L S Kaminer, J Pizzolo, M S Tallman
Journal: Leukemia (2004)
Combined 8-methoxypsoralen and black light therapy of psoriasis TECHNIQUE AND RESULTS
Authors: GERHARD WEBER
Journal: British Journal of Dermatology (1974)

Seventy-four patients with psoriasis underwent a combined topical treatment with an 8-methoxypsoralen solution and black light. In thirty-four patients the skin lesions healed; in twenty-three patients they improved considerably. Eleven patients showed only a moderate regression of the lesions, whilst in six patients treatment was for various reasons discontinued during the first phase, The 8-methoxypsoralen-black light therapy can be performed in out-patients and has the advantage over dithranol treatment of being entirely clean. Relapses are not resistant to further similar treatment.
"How can I help you hear?" The transforming power of six little words
Authors: S. Chapman
Journal: BMJ (2015)

Chinese fund manager performance is interesting because, in a market dominated by speculative retail trading, we expect professional fund managers to have a persistent edge. Using data on the Chinese mutual fund industry, the authors compute a new skill measure to identify exceptional funds with persistent performance. When an equity mutual fund is in the top 1% of their ranking in a particular 6-month period, the probability the fund will be among the top 10% in return in the following period is 22%. By comparison, for funds that rank in the top 1% by past 6-month return, the probability of being a top 10% fund in the next 6 months is only modestly better than noise at 12%. The authors also find declining skill and performance persistence at the industry level, likely driven by the exodus of mutual fund managers to hedge funds. They provide evidence that most of the outperforming funds in China deliver excess performance, relative to peers, through market timing. Funds that reliably pick winning stocks often do not have evidence of performance. This may be related to a mutual fund management culture that emphasizes market timing for managing downside risk over a focus on relative performance. <b>TOPICS:</b>Mutual fund performance, emerging markets, manager selection <b>Key Findings</b> • The authors develop a new mutual fund skill measure that identifies exceptional funds with persistent performance and assesses stock selection and market timing ability. They then apply this measure to Chinese mutual funds. • They demonstrate that some Chinese mutual funds exhibit persistent skill but that industry-wide skill is declining over time—likely because of a migration of the most talented managers from mutual funds to hedge funds. • The authors show that most exceptional Chinese mutual funds deliver excess performance relative to peers through market timing as opposed to stock selection, a finding consistent with management culture emphasizing downside risk management over relative returns.
Abstract 3743: NVP-BYL719, a selective inhibitor of the class Ia PI3K isoform alpha impairs angiogenesis and microvascular permeability.
Authors: Christian R. Schnell, Stephanie Barbe, Giorgio Caravatti, Saskia Brachmann, Daniel Guthy, Sauveur Michel Maira, Robert Cozens, Francesco Hofmann, Christine Fritsch
Journal: Cancer Research (2012)

Abstract Tumor blood vessels are distinctly abnormal in structure and function. When compared to normal vessels, they are enlarged, tortuous, leaky, poorly covered by pericytes and with a defective basement membrane. VEGF is a prominent cytokine responsible for the hyperpermeable state of tumor microvasculature to plasma macromolecules. The phosphatidylinositol 3-kinase (PI3K)-Akt signaling pathway functions downstream of VEGF and can activate the production of the free radical gas nitric oxide (NO) through the enzyme endothelial NO synthase (eNOS), a key player for the in vivo biological activity of VEGF. In the present study, we investigated the effect of NVP-BYL719, a novel, synthetic low molecular mass compound, which potently and selectively inhibits class I PI3K isoform alpha activity, on vascular leakage in tumors and its impact on tumor progression in an orthotopic breast cancer model (BN472) in syngeneic rats. Effects on the vasculature were investigated in normal and tumor tissues via tumor interstitial fluid pressure (IFP) measurements in conscious animals via radio-telemetry and a modified Miles assay. The antiangiogenic effect of NVP-BYL719 and its impact on tumor progression was also assessed in an U87MG glioblastoma subcutaneous xenograft tumor model. Pathway inhibition was confirmed using tumor histology and Reverse Phase Protein Array (RPPA) approaches. NVP-BYL719 inhibits VEGF driven tissue formation as well as neo-vascularization of the newly formed tissue. Moreover, the compound strongly inhibited microvessel permeability in normal tissue as determined in the modified miles assay. Similarly, tumor interstitial fluid pressure (IFP), a phenomenon that is directly dependent on tumor vessel permeability, was significantly reduced (up to 43%) by NVP-BYL719 in a dose-dependent manner, upon oral administration in BN472 mammary carcinoma grown orthotopically in syngeneic rats. Concomitantly, tumor growth was significantly inhibited in BN472 mammary carcinoma and U87MG xenografts. The compound was well tolerated with no significant body weight loss at any tested dose. In conclusion, our data suggest that NVP-BYL719, a Class I PI3K selective inhibitor of p110 alpha, interferes with the tumor vasculature system. Thus, the anti-angiogenic proprieties of NVP-BYL719 might participate to the antitumor activity (or efficacy) of the compound. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3743. doi:1538-7445.AM2012-3743
Factors affecting the solubility of calcium pyrophosphate dihydrate crystals.
Authors: R M Bennett, J R Lehr, D J McCarty
Journal: Journal of Clinical Investigation (1975)

The solubility of triclinic calcium pyrophosphate dihydrate (CPPD) crystals was measured under varying conditions using 45Ca-labeled crystals, expressing solubility as micromoles per liter of 45Ca in solution. In a 0.1-M Tris-HC1 buffer pH 7.4, the solubility of accurately sized CPPD crystals (37-20mum) was 60muM with maximal solubility being attained after about 8 h incubation at 37degreeC. Reduction in crystal size, decrease in pH, increase in ionic strength, Mg++, citrate, and albumin all increased solubility. The most marked effects on solubility occurred when changing the calcium concentration or by enzymatic hydrolysis of inoganic pyrophosphate to orthophosphate. It was found that decreasing the ionized calcium level below 5 mg/100 ml resulted in a progressive enhancement of solubility. The observed solubility-enhancing effects of albumin could be explained solely on its calcium-binding ability and thereby, altered ionized calcium level. Diffusible calcium in synovial fluid was only 40% of the total calcium concentration, which means most joint fluids are normally near the critical concentration of 5 mg/100 ml of ionized calcium, below which solubility is enhanced. During surgery, especially parathyroidectomy, calcium levels fall, favoring dissolution of CPPD crystals. We speculate that the slight decrease in crystal size during dissolution frees them from their cartilaginous mold, resulting in a dose-dependent inflammatory reaction as they are "shed" into the joint space. Crystal shedding may be reinforced by the modest fall in joint fluid pH accompanying the inflammatory response.
Varicella-zoster virus DNA in the oesophageal myenteric plexus in achalasia.
Authors: C S Robertson, B A Martin, M Atkinson
Journal: Gut (1993)

In a search for past or present infection with herpes viruses, serum antibody titres to herpes simplex type 1 virus, cytomegalovirus, and varicella-zoster virus were measured by complement fixation test in 58 patients with achalasia. Serum was also taken from 40 age and sex matched patients without oesophageal symptoms who formed a control group. All titres were low, and those for herpes simplex type 1 virus and cytomegalovirus did not differ in the achalasia patients and the controls. However, the incidence of varicella-zoster virus antibodies was significantly greater in the achalasia than in the control group (p < 0.05). Using oesophageal tissue containing myenteric plexus removed at the time of cardiomyotomy in nine patients with achalasia, in situ DNA hybridisation showed evidence of varicella-zoster virus in three, but all were negative for the other two viruses. No positive results were obtained for herpes simplex type 1 virus, cytomegalovirus, or varicella-zoster virus in oesophageal tissue from 20 patients undergoing oesophageal resection for diseases other than achalasia. The incidence of positivity for varicella-zoster virus was significantly increased in the achalasia group compared with the controls (p < 0.02). The findings indicate that varicella-zoster virus DNA may persist in the oesophageal myenteric plexus in some patients with achalasia and raise the possibility that this virus is of aetiological importance in achalasia.
The effect of hypophysectomy on experimental endothelial cell regrowth and intimal thickening in the rat.
Authors: M A Bettmann, M B Stemerman, B J Ransil
Journal: Circulation Research (1981)

We studied the influence of hypophysectomy on endothelial cell regrowth and intimal thickening following aortic endothelial removal. Modification of this influence by replacement doses of glucocorticoids, mineralocorticoids, thyroxin, and growth hormone also was investigated. Young adult male rats were used, and endothelial removal was achieved by the balloon catheter method. Percent endothelial regrowth and percent intimal thickening were quantified 1 or 2 weeks after injury (3 or 5 weeks after hypophysectomy). One week after injury, endothelial regrowth was 64% in hypophysectomized rats and only 54% in controls. At 2 weeks, values were 80% and 79% respectively. Intimal thickening (percent of wall thickness due to intima) at 1 week was 11% in hypophysectomized and 14% in control rats. At 2 weeks, values were 13% and 22%, respectively. All differences between hypophysectomized and control rats at 2 weeks were statistically significant. Neither endothelial regrowth nor intimal thickening in hypophysectomized rats was altered by hormone replacement. Comparison of areas in which endothelium had not regrown suggested that hypophysectomy had a direct effect on intimal smooth muscle cell proliferation. Thus, hypophysectomy suppresses intimal thickening and accelerates endothelial regrowth after wall injury. Neither effect depends on certain known hormones, and these effects are to some extent independent of one another. These findings are relevant to recent work on growth factors and atherogenesis.