The Inoue-Melnick Virus, Human Herpesvirus Type 6, and the Chronic Fatigue Syndrome
Authors: Janet K. Dale, Stephen E. Straus, Dharam V. Ablashi, Zaki S. Salahuddin, Robert C. Gallo, Yoko Nishibe, Yukishige K. Inoue
Journal: Annals of Internal Medicine (1989)

Letters and Corrections1 January 1989The Inoue-Melnick Virus, Human Herpesvirus Type 6, and the Chronic Fatigue SyndromeJanet K. Dale, RN, BSN, Stephen E. Straus, MD, Dharam V. Ablashi, PhD, Zaki S. Salahuddin, PhD, Robert C. Gallo, MD, Yoko Nishibe, PhD, Yukishige K. Inoue, MDJanet K. Dale, RN, BSNSearch for more papers by this author, Stephen E. Straus, MDSearch for more papers by this author, Dharam V. Ablashi, PhDSearch for more papers by this author, Zaki S. Salahuddin, PhDSearch for more papers by this author, Robert C. Gallo, MDSearch for more papers by this author, Yoko Nishibe, PhDSearch for more papers by this author, Yukishige K. Inoue, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-110-1-92 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: We are studying the possible role of specific viruses in the chronic fatigue syndrome, an illness for which criteria were recently outlined (1). We summarize the results of a serologic study designed to ascertain whether previous infection with Inoue-Melnick virus is a prominent feature of our patients with the chronic fatigue syndrome and, moreover, whether serologic reactivity to the virus is synonymous with reactivity to herpesviruses, including human herpesvirus type 6 (2).The Inoue-Melnick virus is not well defined. It resembles the herpesviruses in size, DNA content, sensitivity to organic solvents, and susceptibility to inhibition by drugs...References1. HolmesKaplanGantz GJN. Chronic fatigue syndrome: a working case definition. Ann Intern Med. 1988;108:387-9. LinkGoogle Scholar2. SalahuddinAblashiMarkham SDP. Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders. Science. 1986;234:596. CrossrefMedlineGoogle Scholar3. MelnickWangSeidel JSE. Characterization of IM virus, which is frequently isolated from cerebrospinal fluid of patients with multiple sclerosis and other chronic diseases of the central nervous system. J Virol. 1984;52:739. CrossrefMedlineGoogle Scholar4. NishibeInoue YY. Inhibitory effect of acyclovir on the growth of Inoue-Melnick virus isolated from cerebrospinal fluid. J Med Virol. 1986;18:309. CrossrefMedlineGoogle Scholar5. Kono R. Subacute myelo-optico-neuropathy, a new neurological disease prevailing in Japan. Japan J Med Sci Biol. 1971;24:195-216. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byChronic Fatigue SyndromeChronic Fatigue SyndromeChronic Fatigue SyndromeReport of a workshop on the epidemiology, natural history, and pathogenesis of chronic fatigue syndrome in adolescentsHuman herpesvirus 6Human herpesvirus 6 and human herpesvirus 7 in chronic fatigue syndromePsychological Aspects of Chronic Fatigue SyndromeA Chronic Illness Characterized by Fatigue, Neurologic and Immunologic Disorders, and Active Human Herpesvirus Type 6 InfectionDedra Buchwald, MD, Paul R. Cheney, MD, PhD, Daniel L. Peterson, MD, Berch Henry, PhD, Susan B. Wormsley, BS, Ann Geiger, BA, Dharam V. Ablashi, DVM, S. Zaki Salahuddin, MS, Carl Saxinger, PhD, Royce Biddle, MD, Ron Kikinis, MD, Ferenc A. Jolesz, MD, Thomas Folks, PhD, N. Balachandran, PhD, James B. Peter, MD, PhD, Robert C. Gallo, MD, Anthony L. Komaroff, MDHuman Herpesvirus 6: The Virus and The Search for Its Role as a Human PathogenChronic Fatigue Syndrome: A ConundrumLe Syndrome de Fatigue Chronique : les hypothèses infectieusesThe chronic fatigue syndrome: a return to common senseThe Chronic Fatigue Syndrome 1 January 1989Volume 110, Issue 1Page: 92-93KeywordsChronic fatigue syndromeDNADrugsHerpesvirusesHuman herpesvirus ePublished: 1 December 2008 Issue Published: 1 January 1989 PDF downloadLoading ...