tbuckley/cabot-search huggingface dataset:
Abstract 1401: Overexpression of HER4 isoforms in transgenic mice reveal isoform-specific role in mammary gland development and carcinogenesis.
Authors: Vikram B. Wali, Maureen Gilmore-Hebert, Klaus Elenius, David F. Stern
Journal: Cancer Research (2013)

Abstract Human epidermal growth factor receptor 4 (HER4/ERBB4) belongs to the family of four receptor tyrosine kinases (HER1-4). While HER1, HER2 and HER3 are often overexpressed in breast cancer and predict poor prognosis, the role of HER4 in cancer is still unclear. Some studies suggest a tumor suppressor role of HER4, while contradictory reports suggest its oncogenic potential. HER4 gene produces multiple isoforms as a result of alternative splicing, in contrast to other members of this receptor family. We have used a gain-of-function MMTV-HER4 model isoforms, to evaluate potential developmental and carcinogenic roles of HER4-CYT1 and CYT2. Mammary gland ductal morphogenesis was significantly suppressed by expressing one of the transgene isoforms, strongly suggesting a role of HER4 in normal mammary ductal morphogenesis in addition to its role in lactation described previously. Interestingly, sustained expression of one HER4 transgene isoform resulted in formation of mammary tumor lesions, whereas no significant findings were observed in the control group. Formation of tumor lesions in these transgenic mice strongly suggests an oncogenic function of a HER4 isoform. These novel findings may help improve the rational design of targeted breast cancer therapy. Supported by NIH grant RO1 CA80065. Citation Format: Vikram B. Wali, Maureen Gilmore-Hebert, Klaus Elenius, David F. Stern. Overexpression of HER4 isoforms in transgenic mice reveal isoform-specific role in mammary gland development and carcinogenesis. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1401. doi:10.1158/1538-7445.AM2013-1401
A SIMPLIFIED METHOD FOR MEASURING BASOPHIL HISTAMINE RELEASE AND BLOCKING ANTIBODIES IN HAY FEVER PATIENTS. BASOPHIL HISTAMINE CONTENT AND CELL PRESERVATION
Authors: P. STAHL SKOV, S. NORN
Journal: Allergy (1977)

A simplified method for measuring basophil histamine release in grass pollen hay fever patients has been developed. Leukocytes were challenged in vitro with extracts of Phleum pratense (timothy) and the release of histamine was determined indirectly as the residual histamine in the cell sediment. Several steps to purify histamine thus became superfluous and histamine was directly conjugated with o-phthaldialdehyde to form a fluorophore. The simplified method showed a basophil histamine content which was in accordance with results obtained by more specific methods. No difference in basophil histamine content was found between normal and allergic persons. For the histamine liberation assay blood could be adequately preserved for transport for 48 h at room temperature by adding cell culture medium. Basophil histamine release technique allows evaluation of cell sensitivity for determination of the degree of allergy as well as the level of blocking antibodies.
Successful Replacement of "Parachute" Mitral Valve in a Child
Authors: SANTIAGO PRADO, MORRIS LEVY, R. L. VARCO
Journal: Circulation (1965)

A Starr-Edwards mitral valve of orifice area 1.53 cm. 2 was successfully inserted to replace [see figure in the PDF file] [see table in the PDF file] a "parachute" mitral valve producing clinically significant mitral stenosis.
Nonmyeloablative allografting for newly diagnosed multiple myeloma: the experience of the Gruppo Italiano Trapianti di Midollo
Authors: Benedetto Bruno, Marcello Rotta, Francesca Patriarca, Daniele Mattei, Bernardino Allione, Fabrizio Carnevale-Schianca, Roberto Sorasio, Alessandro Rambaldi, Marco Casini, Matteo Parma, Pasqua Bavaro, Francesco Onida, Alessandro Busca, Luca Castagna, Edoardo Benedetti, Anna Paola Iori, Luisa Giaccone, Antonio Palumbo, Paolo Corradini, Renato Fanin, David Maloney, Rainer Storb, Ileana Baldi, Umberto Ricardi, Mario Boccadoro
Journal: Blood (2008)
CARBON DIOXIDE AND OXYGEN IN OBSTETRICS
Authors: W. T. McCONNELL
Journal: JAMA (1933)

The presentation of this paper is in the nature of a preliminary report of our observations over the last two years in our private work, and during the past year in the Louisville City Hospital. The subject matter herewith deals principally with the clinical results, together with a brief discussion of physiology, in our use of carbon dioxide and oxygen mixtures as a therapeutic agent in the treatment of some complications of obstetrics. We plan, at a later date, to report the results of experimental laboratory studies on this subject. Among the complications thus treated are asphyxia and atelectasis neonatorum, postlabor and postanesthesia shock, uterine inertia during labor, postpartum hemorrhage, the terminal depression of severe toxemia, and postcesarean abdominal distention.  Current literature teems with the controversy between a group of investigators who contend that carbon dioxide is superfluous and harmful to the asphyxiated new-born infant1and another group2
PREVALENCE OF DIETARY SUPPLEMENT USE AMONG ELITE IRANIAN ATHLETES (MALE &amp; FEMALE NATIONAL LEVEL ATHLETES)
Authors: A Golshanraz, H Laleh, P Lotfali
Journal: British Journal of Sports Medicine (2014)

Background Dietary supplement use is common in athletes. Besides their cost, they may have side effects on health and performance. They may also cause inadvertent doping violation. Objective The study aimed to explore the frequency, type, believes, attitudes and knowledge of participants regarding dietary supplements. Design KAP analysis, cross sectional, cluster sampling, year 2011. Setting Face to face data gathering strategy from national level athletes performed based on valid questionnaire. Participants 350 national level athletes (mean age 21.87 years) from 26 different sports fields and both sexes. Risk factor assessment Age, sex, level of education, sports field, history of sports participation, weight, height, body mass index. Main Outcome Measurements Knowledge was good in 36.70%, average in 59.80%, and poor in 3.20% of respondents. 65% of them either did not use any sports supplements at all, or they used less than 2 times weekly. The most widely used supplements were vitamins (m=76.9%, f=77.4%), energy supplements (m=56.9%, f=47.1%), and minerals (m=44.6%, f=57.4%). 72.1% of athletes believed in their efficacy, 40.2% experienced performance enhancement and 11.4% reported side effects. Over 60% rated their knowledge inadequate and 57.5% were eager to learn more. Conclusions Many athletes believe in the efficacy of supplements and think they are an unavoidable part of competitive sports. Considering three aspects of supplement consumption –safety, efficacy, legitimacy, it should be focused that "optimal dietary intake is the basics for sport for life". We have to stress on education, consulting sessions, and rational prescription.
Adverse Reactions during Salicylazosulfapyridine Therapy and the Relation with Drug Metabolism and Acetylator Phenotype
Authors: K. M. Das, M. A. Eastwood, J. P. A. McManus, W. Sircus
Journal: New England Journal of Medicine (1973)

Most of the toxic symptoms ascribed to salicylazosulfapyridine can be related to high serum concentrations of total sulfapyridine (>50 μg per milliliter). No such correlation is observed with serum concentrations of salicylazosulfapyridine, sulfapyridine metabolites or the other metabolite of salicylazosulfapyridine, 5-aminosalicylic acid. The majority of 28 patients with side effects were taking 4 g or more of salicylazosulfapyridine per day, and most of them were slow acetylator phenotypes. The sulfapyridine-related toxic symptoms can be overcome if salicylazosulfapyridine is stopped temporarily or reduced in dosage. By this method, the therapy could be continued in 26 out of 28 patients who exhibited side effects. A decrease in serum total sulfapyridine concentration coincided with the improvement of the symptoms. Reintroduction of a therapeutic dose of salicylazosulfapyridine was achieved by an initially small dose, which was then gradually increased. Regular blood examination in patients during the initial therapy or during change of dosage is indicated, and patients' acetylator phenotype should be ascertained. (N Engl J Med 289:491–495, 1973)
TCT-776 Safety of Axillary and TransAortic Approaches for Transcatheter Aortic Valve Replacement in patients older than 85 years old: Results from Italian CoreValve Registry
Authors: Claudia Fiorina, Marco De Carlo, Federico De Marco, Corrado Tamburino, Gian Paolo Ussia, Luca Testa, Francesco Bedogni, Antonio Colombo, Ermanna Chiari, Felicia Lipartiti, Anna Sonia Petronio, Diego maffeo, Federica Ettori
Journal: Journal of the American College of Cardiology (2013)
Treatment of wrongly assigned sex.
Authors: C. N. Armstrong
Journal: BMJ (1966)

The purpose of this paper is to rebut the assertion that reassign ment or change of sex necessarily constitutes an extreme psychological hazard for individuals who have been assigned to the wrong sex at birth. Some doubt will also be thrown on the claim that psychological sex?normal or abnormal?develops entirely as a consequence of environmental psychological experience, like learning a language, and is neither innate nor influenced by hormones. Money (1955, 1963), Hampson (1955), Money et al. (1957), and Hampson and Hampson (1961), who carried out investi gations on cases of intersexuality, are responsible for comparing the  role?that is, the psychological sex?to the learning of one's native language and asserting that the gender role is in agreement with the sex of rearing and not instinctively determined by chromosomes, gonads, or hormones. They concluded that reassignment of the sex of rearing was without doubt psychologically injurious and constituted an extreme psychological hazard. There is no doubt that the conclusions of Money and the Hampsons have profoundly influenced the treatment of wrongly assigned sex, particularly in North America, where the attitude is more rigid and where change of sex would cause greater social reactions than in Europe. Although Dennison (1965) agrees with Money, it has not been the experience of Cappon et al. (1959) or of mine (Armstrong, 1964). I find it difficult to accept that in man the psychological sex, or the gender role, is solely dependent upon psychological environmental factors, such as the sex of rearing, and indepen dent of hormones. Herbert and Michael (1965) and Michael et al. (1966) have shown that in rhesus monkeys the sexual perform ance of the males depends on the endocrine status of their female partners. Sexual variety of the male varied with the phases of the female menstrual cycle, and bilateral ovariectomy of the female suppressed or greatly reduced the sexual activity of the male ; this was readily restored after administration of oestradiol to the ovariectomized female. The administration of progesterone to females already receiving oestrogen resulted in a notable reduction in the ejaculatory capacity of their male partners. The types of cases which in my opinion can?and should? be reassigned without psychological hazard are particularly cases of hypospadias in boys assigned and reared as girls and cases of congenital adrenal hyperplasia in girls assigned and reared as boys. The former can be corrected by surgery and the latter by hormone therapy, and if normality can be achieved it is obviously preferable that the patients should be treated rather than that they should be allowed to continue their lives as a pathological abnormality. It has always been my practice to treat cases of congenital adrenal hyperplasia with hydro cortisone and reassignment of sex, if necessary, and I have never encountered any difficulties.
Lead Encephalopathy Simulating Subdural Hematoma in an Adult
Authors: Joseph W. Hess
Journal: New England Journal of Medicine (1961)

LEAD encephalopathy is increasingly rare in adults.The most recent report found in English-language publications was an account by Boyd1 in 1957, in which the symptoms were very mild. Brieger and Rieders,2 in a recent review, stated, "Like lead palsy, lead encephalopathy is almost never seen at present in adults." In a Public Health Association monograph3 in 1943 the following comment was made:Cerebral lead intoxication is the most serious manifestation of lead poisoning and also the rarest, except in the case of children, among whom it is the prevalent type. It occurs in the adult only as the consequence . . .
Genetic polymorphism of the type A human natriuretic peptide receptor (NPR‐A) gene contributes to the interindividual variability in the BNP system
Authors: Michael Weber, Maria Burian, Ivana Dragutinovic, Helge Moellmann, Holger Nef, Albrecht Elsaesser, Veselin Mitrovic, Christian Hamm, Gerd Geisslinger
Journal: European Journal of Heart Failure (2008)
Circle could take a third of any surplus before Hinchingbrooke's debts are cleared
Authors: M. Limb
Journal: BMJ (2012)

The controversial takeover of an NHS hospital by the private healthcare firm Circle has come under fresh attack after details emerged of the profits to be taken under the deal.

Critics claimed that the contract to run Hinchingbrooke Hospital, Huntingdon, Cambridgeshire, gave Circle a financial incentive to make “eye watering cuts” to services and jobs.

But Circle’s chief executive, Ali Parsa, defended the deal, saying that the company was already radically improving a hospital that could have closed or lost taxpayers “many tens of millions in the years ahead.”

Circle took over the running of the hospital, which has debts of nearly £40m (€49m; $65m), on 1 February 2012, in a 10 year deal approved by the government. …
Science on Trial: The Clash of Medical Evidence and the Law in the Breast Implant Case
Authors: Lorna A. Marshall
Journal: JAMA (1996)

<i>Science on Trial</i>is an account of the breast implant controversy. It relates the events that led to the 1992 decision by Food and Drug Administration Commissioner David Kessler to ban siliconegel—filled breast implants. It includes accounts of the hysteria that followed and the litigation that eventually led to the largest class action settlement in the history of trial courts. However, the focus of the book is really on what the author, Marcia Angell, MD, believes was missing from this controversy: attention to and respect for scientific evidence as a means to reach the truth. Angell describes the litigation surrounding breast implants from the perspective of a physician dedicated to the use of the scientific method. As executive editor of the<i>New England Journal of Medicine</i>, she has followed the events and dealt directly with pertinent studies. Her concern is that greed and emotion, not scientific evidence, have become the
Effects of flecainide on ectopic atrial automaticity and conduction.
Authors: J R Windle, R C Witt, G J Rozanski
Journal: Circulation (1993)

Previous studies have shown that class Ic antiarrhythmic agents are effective in suppressing ectopic atrial rhythms and accessory pathway conduction.To explore the potential mechanisms for their effectiveness, we investigated the concentration-dependent effects of the Ic agent flecainide acetate (0.5 to 10 micrograms/mL) on atrial ectopic automaticity and exit conduction in isolated rabbit tricuspid valves. This experimental model consists of three major cell types as defined anatomically and by intracellular recordings: pacemaker, transitional, and working atrial muscle. Simultaneous recordings from these cell types before and during flecainide superfusion (n = 7) showed that the drug produced a slight, concentration-dependent slowing of pacemaker-transitional conduction but elicited third-degree transitional-working atrial muscle block in six of seven preparations at 10 micrograms/mL. Flecainide caused a significant dose-dependent reduction in the initial phase of diastolic depolarization of pacemaker cells but produced only a small, biphasic change in spontaneous pacemaker cycle length. It also caused a significant prolongation in action potential duration in pacemaker and transitional cells and reduction in upstroke velocity in atrial cells. Of note in four additional preparations, flecainide caused a concentration-dependent upward shift in the strength-duration curve for atrial fibers.These data suggest that flecainide has little direct effect on ectopic atrial automaticity but rather causes exit conduction slowing and block between transitional and atrial muscle fibers. The mechanism for the induction of block is likely due to a decrease in atrial excitability creating a greater electrical load on generated impulses.
The Familial Muir-Torre Syndrome
Authors: Frederick P. Li, Charis Eng
Journal: Annals of Internal Medicine (1993)

Letters15 September 1993The Familial Muir-Torre SyndromeFrederick P. Li, MD and Charis Eng, MDFrederick P. Li, MDSearch for more papers by this author and Charis Eng, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-6-199309150-00033 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Colorectal cancer tends to aggregate in families. A small fraction of these families have adenomatous polyposis coli caused by inherited mutations in the APC gene on chromosome 5q [1]. Hereditary nonpolyposis colon cancer is more common although heterogeneous and difficult to define [2]. We recently identified a family with exceptionally prominent features of the Muir-Torre syndrome, a clinically distinct form of hereditary nonpolyposis colon cancer characterized by sebaceous neoplasms of the skin and associated with cancers of the colon, rectum, and genitourinary tract [3].Figure 1.Condensed pedigree of three generations (I to III) of the family.Patients II-2 ...References1. Peltomaki P, Sistonen P, Mecklin JP, Pylkkanen L, Aaltonen L, Nordling S, et al. Evidence that the MCC-APC gene region in 5q21 is not the site for susceptibility to hereditary nonpolyposis colorectal carcinoma. Cancer Res. 1992; 52:4530-3. Google Scholar2. Bufill JA. Colorectal cancer: evidence for distinct genetic categories based on proximal or distal tumor location. Ann Intern Med. 1990; 113:779-88. Google Scholar3. Cohen PR, Kohn SR, Kurzrock R. Association of sebaceous gland tumors and internal malignancy: the Muir-Torre syndrome. Am J Med. 1991; 90:606-13. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByMuir-Torre syndrome: Case report of a patient with concurrent jejunal and ureteral cancer and a review of the literatureGenitourinary tumors in men with the Muir-Torre syndromeThe Muir-Torre syndrome: A 25-year retrospectMuir-Torre SyndromeMuir-Torre syndrome: a variant of the cancer family syndrome.Markers of Risk for Human Malignancies 15 September 1993Volume 119, Issue 6Page: 539KeywordsAdenomasColonColorectal cancerHereditary nonpolyposis colorectal cancerMolecular biologyMutationRectal cancerRectumSmall intestineStomach Issue Published: 15 September 1993 CopyrightCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Simultaneous Streptococcus and Picornavirus Infection
Authors: Charles B. Porter
Journal: JAMA (1981)

Streptococci seldom invade muscle in healthy people with intact integument. However, infection with another agent simultaneously may change this general observation. In a two-week period we encountered dual infections with group A, beta-hemolytic streptococci and a picornavirus in each of two hospitalized patients. Both were acutely ill; one died. Renal failure developed in the patient who survived and rhabdomyolysis was demonstrated in the patient who died. Picornavirus titer increases were demonstrated in the patient who survived, and viral inclusions in muscle cells were demonstrated by light microscopy in necropsy specimens and confirmed by electron microscopy in the second patient. We believe that streptococcal invasion of muscle may be facilitated during an outbreak of certain picornavirus infections.
Familial Hypocalciuric Hypercalcemia: Recognition Among Patients Referred After Unsuccessful Parathyroid Exploration
Authors: STEPHEN J. MARX
Journal: Annals of Internal Medicine (1980)

Of 67 patients referred after unsuccessful surgery for presumed primary hyperparathyroidism, six were shown to be members of kindreds with familial hypocalciuric hypercalcemia. This diagnosis had not been recognized in any of the six previously. Most of the remaining 61 cases had proven or probable typical primary hyperparathyroidism, and a subgroup of four had hypercalcemia with suppression of the parathyroid glands. Urine calcium excretion expressed as the calcium:creatinine clearance ratio provided an easily measurable and effective index to separate the groups with familial hypocalciuric hypercalcemia, typical primary hyperparathyroidism, and suppressed parathyroids. Thus, at least 9% of patients referred after unsuccessful parathyroidectomy had familial hypocalciuric hypercalcemia. The assessment of urine calcium excretion by indices such as the calcium:creatinine clearance ratio should facilitate recognition of this condition, which responds poorly to standard subtotal parathyroidectomy.
Changes in cardiac myocyte morphology alter the properties of voltage-gated ion channels
Authors: K Walsh
Journal: Cardiovascular Research (2002)

Objective: The goal of this study was to determine if the properties of the transient outward potassium (Ito), TTX-resistant sodium (INa) and L-type calcium (ICa) currents are altered during changes in cardiac cell shape. Methods: Ventricular myocytes were isolated from 3- to 4-day-old neonatal rats and cultured on either non-aligned or aligned collagen thin gels. In contrast to the flat, stellar-shaped myocytes obtained when the cells are plated on non-aligned collagen gels, myocytes plated on aligned gels display an elongated, rod-like shape. Ion channel expression was measured using the whole-cell arrangement of the patch clamp technique and Western blot analysis. Results: Peak values for Ito, INa and ICa were 9±1, 71±13 and 7±1 pA/pF, respectively, in the flat cells, and increased to 21±2, 190±26 and 13±1 pA/pF, respectively, in the aligned cells. Application of forskolin (2 μM) and 3-isobutyl-1-methylxanthine (100 μM) resulted in a 101±18% increase in ICa in the flat cells, but increased the current by only 43±9% in the aligned cells. Internal dialysis of the myocytes with cAMP strongly increased the peak ICa in the flat cells, but caused no significant change in the aligned cells. While both basal and forskolin-stimulated levels of cAMP were the same in the two cell morphologies, the expression of the calcium channel α1C subunit was increased in the aligned cells. Conclusions: The expression and regulatory properties of voltage-gated calcium channels are modified during changes in neonatal rat myocyte shape.
Childhood bullous pemphigoid: Immunohistochemical, immunoelectron microscopic, and Western blot analysis
Authors: Toru Nagano, Masahiro Tani, Atsuko Adachi, Tetsuya Takanaga, Sachiko Sakamoto, Soichi Kodama, Sakuhei Fujiwara
Journal: Journal of the American Academy of Dermatology (1994)
Long-term results of treatment of childhood acute lymphoblastic leukemia in the Czech Republic
Authors: J Stary, Y Jabali, J Trka, O Hrusak, P Gajdos, H Hrstkova, J Sterba, B Blazek, J Hak, D Prochazkova, Z Cerna, P Smisek, P Sedlacek, V Vavra, V Mihal, O Hrodek
Journal: Leukemia (2009)