Deoxycholate or Amphotericin B in Chemotherapy Sensitization
Authors: STEVEN D. REICH
Journal: Annals of Internal Medicine (1977)

Comments and Correction1 May 1977Deoxycholate or Amphotericin B in Chemotherapy SensitizationSTEVEN D. REICH, M.D.STEVEN D. REICH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-86-5-656 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The use of amphotericin B as a sensitizing agent during combination chemotherapy in human neoplasia has been reported by Presant, Klahr, and Santala (1). An implication of the lack of an important control population in this study deserves comment.The commercial preparation of amphotericin B, Fungizone® (E. R. Squibb, Princeton, New Jersey), is prepared with 41 mg of sodium deoxycholate to every 50 mg of amphotericin B. The deoxycholate is used to form a colloidal dispersion because crystalline amphotericin B is insoluble in water. Both amphotericin B and deoxycholate have cell-membrane altering effects that can increase the...References1. PRESANT C, KLAHR C, and SANTALA R: Amphotericin B induction of sensitivity to adriamycin, 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU) plus cyclophosphamide in human neoplasia. Ann Intern Med 86:47-51, 1977 LinkGoogle Scholar2. MEDOFF G, VALERIOTE F, and LYNCH R: Synergistic effect of amphotericin B and 1,3-bis (2-chloroethyl)-1-nitrosourea against a transplantable AKR leukemia. Cancer Res 34:974-978, 1974 MedlineGoogle Scholar3. KESSEL D: Alteration of cell permeability barriers by amphotericin B-deoxycholate (Fungizone) in vitro. Biochem Pharmacol 25:483-485, 1976 CrossrefMedlineGoogle Scholar4. RIEHM H and BIEDLER J: Potentiation of drug effect by Tween 80 in Chinese hamster cells resistant to actinomycin D and daunomycin. Cancer Res 32:1195-1200, 1972 MedlineGoogle Scholar1. PRESANT C, KLAHR C, and SANTALA R: Amphotericin B induction of sensitivity to adriamycin, 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU) plus cyclophosphamide in human neoplasia. Ann Intern Med 86:47-51, 1977 LinkGoogle Scholar2. PRESANT C, KLAHR C, and OLANDER J: Amphotericin B plus 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU-NSC No. 409962) in advanced cancer. Cancer 38:1917-1921, 1976 CrossrefMedlineGoogle Scholar3. KESSEL D: Alteration of cell permeability barriers by amphotericin B-deoxycholate (Fungizone) in vitro. Biochem Pharmacol 25:483-485, 1976 CrossrefMedlineGoogle Scholar4. MEDOFF J, MEDOFF G, and GOLDSTEIN M: Amphotericin B induced sensitivity to actinomycin D in drug-resistant HeLa cells. Cancer Res 35:2548-2552, 1975 MedlineGoogle Scholar5. MEDOFF G, VALERIOTE F, and LYNCH R: Synergistic effect of amphotericin B and 1,3-bis (2-chloroethyl)-1-nitrosourea against a transplantable AKR leukemia. Cancer Res 34:974-978, 1974 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: STEVEN D. REICH, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byChapter 13. Antineoplastic Agents 1 May 1977Volume 86, Issue 5Page: 656-657KeywordsAmphotericinChemotherapeutic agentsChemotherapyCombination chemotherapySodium ePublished: 1 December 2008 Issue Published: 1 May 1977 PDF downloadLoading ...