Thrombotic Thrombocytopenic Purpura Fails to Respond to Fresh Frozen Plasma Infusion
Authors: JACK ANSELL
Journal: Annals of Internal Medicine (1978)

Brief Reports1 November 1978Thrombotic Thrombocytopenic Purpura Fails to Respond to Fresh Frozen Plasma InfusionJACK ANSELL, M.D., RICHARD S. BEASER, M.D., LIBERTO PECHET, M.D., F.A.C.P.JACK ANSELL, M.D.Search for more papers by this author, RICHARD S. BEASER, M.D.Search for more papers by this author, LIBERTO PECHET, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-89-5-647 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRecent reports have emphasized the therapeutic success of exchange transfusion (1, 2), plasmapheresis (3), and plasma infusion (4) in the treatment of thrombotic thrombocytopenic purpura. We report a case of this disease showing the effectiveness of exchange transfusion and plasmapheresis and the failure of fresh frozen plasma infusion.A 28-year-old white woman presented with severe headaches and fatigue. Physical examination showed a pale, lethargic woman with scattered petechiae. There was no lymphadenopathy or hepatosplenomegaly and the results of the remainder of the examination were unremarkable. Laboratory data showed an hematocrit of 23%, reticulocyte count of 13%, microangiopathic erythrocyte structure, and...References1. BUKOWSKIHEWLETTHARRISHOFFMANBATTLESILVERBLATTYANG RJJGJEI: Exchange transfusions in the treatment of thrombotic thrombocytopenic purpura. Semin Hematol 13:219-232, 1976 MedlineGoogle Scholar2. PISCIOTTAGARTHWAITEDARINASTER ATJR: Treatment of thrombotic thrombocytopenic purpura by exchange transfusion. Am J Hematol 3:73-82, 1977 CrossrefMedlineGoogle Scholar3. BUKOWSKIKINGHEWLETT RJJ: Plasmapheresis in the treatment of thrombotic thrombocytopenic purpura. Blood 50:413-417, 1977 CrossrefMedlineGoogle Scholar4. BYRNESKHURANA JM: Treatment of thrombotic thrombocytopenic purpura with plasma. N Engl J Med 297:1386-1389, 1977 CrossrefMedlineGoogle Scholar5. NYDEGGERLAMBERTGERBERMIESCHER VPHP: Circulating immune complexes in the serum in systemic lupus erythematosus and in carriers of hepatitis B antigen. J Clin Invest 54:297-309, 1974 CrossrefMedlineGoogle Scholar6. HANDINSTOSSEL RT: Phagocytosis of antibody-coated platelets by human granulocytes. N Engl J Med 290:989-993, 1974 CrossrefMedlineGoogle Scholar7. MORRISONMCMILLAN JR: Elevated platelet-associated IgG in thrombotic thrombocytopenic purpura. JAMA 238:1944-1945, 1977 CrossrefMedlineGoogle Scholar8. MANTCAUCHIMEDLEY MMG: Thrombotic thrombocytopenic purpura: report of a case with possible immune etiology. Blood 40:416-421, 1972 CrossrefMedlineGoogle Scholar9. BAYERTHEOFILOPOULESEISENBERGFRIEDMANGUZE AARSL: Thrombotic thrombocytopenic purpura-like syndrome associated with infective endocarditis. JAMA 237:408-410, 1977 CrossrefGoogle Scholar10. NEAMEHIRSH PJ: Circulating immune complexes in thrombotic thrombocytopenic purpura (letter). Blood 51:559, 1978 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Massachusetts Medical Center Worcester, Massachusetts PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByClinical applications of therapeutic apheresisThrombotic thrombocytopenic purpura: 24 years of experience at the American University of Beirut Medical CenterManagement Of Thrombotic Thrombocytopenic PurpuraCharacterization of platelet glycoproteins and platelet/endothelial cell antibodies in patients with thrombotic thrombocytopenic purpuraImprovement in Survival in TTP-HUS During the Past Decade: Prospective Study of 108 PatientsThrombotic thrombocytopenic purpura: Clinical results of a French controlled trialImproved Survival in Thrombotic Thrombocytopenic Purpura–Hemolytic Uremic SyndromeThrombotic Thrombocytopenic Purpura and Related DisordersThrombotic Thrombocytopenic Purpura: Successful Treatment Unlocks Etiologic SecretsThe gingival biopsy in the diagnosis of thrombotic thrombocytopenic purpuraThrombotic thrombocytopenic purpura—Dramatic response to plasmapheresisThrombotic Thrombocytopenic PurpuraThrombotic thrombocytopenic purpura: Report of caseThrombocytopeniaPlasma Therapy for Thrombotic Thrombocytopenic PurpuraEfficacy of several plasma components in a young boy with chronic thrombocytopenia and hemolytic anemia who responds repeatedly to normal plasma infusionsTwo successful pregnancies in a woman with chronic thrombotic thrombocytopenic purpura treated by plasma infusionTHROMBOTIC THROMBOCYTOPENIC PURPURATreatment of thrombotic thrombocytopenic purpura with plasma exchange: Five casesHemolytic Uremic Syndrome and Thrombotic Thrombocytopenic PurpuraPurification and some properties of a protein obtained from normal human plasma which inhibits the platelet aggregation induced by thrombotic thrombocytopenic purpura plasmaThrombocytopenia Due to Non-immune Platelet DestructionStudies of a patient with recurring thrombotic thrombocytopenic purpuraWhat Are the Established Clinical Indications for Therapeutic Plasma Exchange and How Important Is the Choice of Replacement Fluid for Efficacy of Therapeutic Plasma Exchange in These Situations?Thrombotic Thrombocytopenic PurpuraJ. 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MEISTER, M.D., RONALD A. SACHER, M.B., B.CH., TERENCE PHILLIPS, PH.D. 1 November 1978Volume 89, Issue 5_Part_1Page: 647-648KeywordsBlood plasmaFatigueHematocritHepatosplenomegalyResearch laboratoriesReticulocytesThrombotic thrombocytopenic purpura Issue Published: 1 November 1978 PDF DownloadLoading ...