tbuckley/cabot-search huggingface dataset:
HTLV-III/LAV-Seronegative, Virus-Negative Sexual Partners and Household Contacts of Hemophiliacs
Authors: Terri McFadden
Journal: JAMA (1986)

To the Editor.—  Public concern about the transmissibility of human T-cell lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) has been heightened by several reports suggesting the existence of an antibody-negative, virus-positive state in some asymptomatic sex partners of persons who are antibody positive. 1-5 We recently evaluated 88 household members and/or sex partners of persons with hemophilia and found that only two nonhemophiliacs were HTLV-III/LAV antibody-positive. 6 We report herein the results of culturing peripheral blood lymphocytes of 20 of the nonhemophiliac contacts whose index hemophiliac was antibody positive.  Report of a Study.—  These contacts included ten of 14 sex partners of 12 persons with either the acquired immunodeficiency syndrome (AIDS) or the AIDS-related complex, two of 16 sex partners of asymptomatic hemophiliacs, and eight household members who were not sex partners (four fathers, three mothers, and one brother of six asymptomatic hemophiliacs aged 5 to 13 years). Sex partners reported
Role of non-governmental organisations in operations research in low-resource countries
Authors: Florence Nyangara
Journal: The Lancet Global Health (2014)

BackgroundResearch partnerships among practitioners, researchers, and affected communities are increasingly seen as important vehicles for translating findings to operational strategies. However, non-governmental organisations (NGOs) are often overlooked as originators and users of research. I aimed to show that NGOs have experience in several countries, and established structures, networks, and relationships with communities that place them in a unique position to link research and practice.MethodsI explored the experiences of 19 NGOs undertaking operations research studies within child survival programmes supported by the US Agency for International Development across 23 countries. These NGOs are implementing a wide range of health services in underserved communities for improved and equitable outcomes. The studies include diverse interventions and study designs. I used data from the entire population of 30 projects funded for 3–5 years in 2008–12 to undertake operations research. I assessed partnerships, relevance, and acceptance for each project.FindingsSo far, the NGOs have formalised 151 partnerships including 64 community-based partnerships, 55 national partnerships, 17 global partnerships, and 16 partnerships with northern researchers and nine with southern researchers. I found that all 30 projects are addressing issues of local relevance as shown in national strategic priorities, whereas 21 are linked to global priorities. High acceptance of the operations research projects as shown by broadly favourable opinions, support, and participation of local stakeholders.InterpretationNGOs are well positioned to identify programme challenges, and propose and test solutions to generate findings of immediate use. Future research projects should consider partnerships with NGOs.FundingUS Agency for International Development.
Massive Pericardia! Effusion Due to Idiopathic Cholesterol Pericarditis Detected During 99 mTc-Pyrophosphate Imaging
Authors: VICTOR F. HUCKELL, HOWARD M. STANILOFF, DAVID H. FEIGLIN, VIRGINIA FLINTOFT, JOHN E. MORCH
Journal: Clinical Nuclear Medicine (1978)

HUCKELL, VICTOR F. M.D., F.R.C.P. (C); STANILOFF, HOWARD M. M.D., F.R.C.P. (C); FEIGLIN, DAVID H. M.B.B.S., F.R.C.P. (C); FLINTOFT, VIRGINIA R.N.; MORCH, JOHN E. M.D., F.R.C.P. (C) Author Information
Correlation of angiographic and autopsy left ventricular dimensions in children.
Authors: E A Fisher, F A Eckner, I W DuBrow, A R Hastreiter
Journal: Circulation (1978)

To evaluate controlled pressure coronary artery perfusion fixation of hearts as a means of obtaining meaningful cardiac measurements at autopsy, left ventricular (LV) autopsy measurements were correlated with in vivo end-diastolic (D) and end-systolic (S) angiographic (angio) values from biplane cineangiograms in the same patients. Mitral (MV) and aortic valve (AV) circumferences, LV equatorial circumference (Circ), spatial inflow and outflow lengths, wall thickness (W) and LV volume (Vol) were measured in 34 children with congenital heart disease. All dimensions showed significant correlation of angiographic and autopsy data from which linear regression equations were derived. The r values obtained were: MV 0.74; AV 0.85; D Circ 0.83; S Circ 0.82; D inflow 0.92; S inflow 0.90; D and S outflow 0.96; W 0.78; D Vol 0.92; S Vol 0.86. Mean angio and autopsy values were not significantly different for AV, S inflow, and S Vol. Autopsy values were lower than all D angio values and MV (P less than 0.001 for all), and higher than angio W and S outflow (P less than 0.001 for both). The data show that changes of LV morphology with this fixation method are predictable, making estimation of in vivo values from autopsy measurements possible using the derived linear regression equations.
Prevalence of Migraine Headache in the United States
Authors: Walter F. Stewart
Journal: JAMA (1992)

To describe the magnitude and distribution of the public health problem posed by migraine in the United States by examining migraine prevalence, attack frequency, and attack-related disability by gender, age, race, household income, geographic region, and urban vs rural residence.In 1989, a self-administered questionnaire was sent to a sample of 15,000 households. A designated member of each household initially responded to the questionnaire. Each household member with severe headache was asked to respond to detailed questions about symptoms, frequency, and severity of headaches.A sample of households selected from a panel to be representative of the US population in terms of age, gender, household size, and geographic area.After a single mailing, 20,468 subjects (63.4% response rate) between 12 and 80 years of age responded to the survey. Respondents and non-respondents did not differ by gender, household income, region of the country, or urban vs rural status. Whites and the elderly were more likely to respond. Migraine headache cases were identified on the basis of reported symptoms using established diagnostic criteria.17.6% of females and 5.7% of males were found to have one or more migraine headaches per year. The prevalence of migraine varied considerably by age and was highest in both men and women between the ages of 35 to 45 years. Migraine prevalence was strongly associated with household income; prevalence in the lowest income group (less than $10,000) was more than 60% higher than in the two highest income groups (greater than or equal to $30,000). The proportion of migraine sufferers who experienced moderate to severe disability was not related to gender, age, income, urban vs rural residence, or region of the country. In contrast, the frequency of headaches was lower in higher-income groups. Attack frequency was inversely related to disability.A projection to the US population suggests that 8.7 million females and 2.6 million males suffer from migraine headache with moderate to severe disability. Of these, 3.4 million females and 1.1 million males experience one or more attacks per month. Females between ages 30 to 49 years from lower-income households are at especially high risk of having migraines and are more likely than other groups to use emergency care services for their acute condition.
Abstract 3939: Hypoxia-induced BRCA1 phosphorylation and degradation
Authors: Yuhong Lu, Peter Michael Glazer
Journal: Cancer Research (2012)

Abstract Hypoxia is a key feature of tumor microenviroment. We have demonstrated that hypoxia downregulates BRCA1 at the transcriptional level through promoter binding by E2F4/p130 complexes and that hypoxia can produce BRCA1 gene silencing via epigenetic modifications. We also demonstrated that downregulation of BRCA1 by hypoxia leads to decreased DNA repair capacity, establishing a mechanism by which hypoxia can drive genetic instability in cancer cells. In addition to transcriptional regulation, BRCA1 has been found to be phosphorylated at S988 in a Chk2-dependent manner by both ionizing radiation and hypoxia exposure. In this study, we have been able to confirm that other residues of BRCA1 are phosphoylated during hypoxia exposure, including S1387, S1423, S1466, and S1524. Intriguingly, the phosphoryation of BRCA1 only happens under severe hypoxic condition, such as 0.01% oxygen, but not under moderate hypoxia (1% oxygen condition). Furthermore, the BRCA1 phosphoylation events induced by hypoxia can be attenuated by an ATM inhibitor, KU55933, indicating that ATM is playing a role in hypoxia-induced BRCA1 phosphorylation at multiple sites. We also observed that the decrease in BRCA1 protein levels in hypoxia is partially blocked by MG132, a proteasome inhibitor. Consistent with this, by transient transfection of exogenous BRCA1, we found that hypoxia induces BRCA1 unbiquitination in MCF-7 cells. Together, our data suggest that hypoxia-induced downregulation of BRCA1 is in part mediated through the ubiqutin-proteasome pathway. Our findings indicate a new mechanism of hypoxia induced regulation of BRCA1 by modulating its stability, suggesting that hypoxia-induced downregulation of BRCA1 is through multiple mechanisms. Future studies will investigate the mechanism of hypoxia-induced BRCA1 phophorylation and the relation between hypoxia-induced BRCA1 phosphorylation and BRCA1 degradation. To understand more about regulation of BRCA1 by hypoxia could lead to new therapies to target hypoxic tumors. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3939. doi:1538-7445.AM2012-3939
Clinical comparison of systemic methylprednisolone acetate versus topical budesonide in patients with seasonal allergic rhinitis
Authors: W. J. Pichler, T. Klint, M. Blaser, W. Graf, K. Sauter, S. Weiss, K. Witschi
Journal: Allergy (1988)

Thirty patients with seasonal allergic rhinitis entered a double blind study comparing budesonide (nasal spray, 400 micrograms/d) and i.m. injection of 80 mg methylprednisolone acetate. Symptoms were assessed over a "run in" period of 3-7 days followed by a treatment period of 3 weeks. Pollen counts were evaluated daily. Both the systemic and topical corticosteroid treatment resulted in a significant improvement of nasal and ocular symptoms and were accompanied by reduced antihistamine intake. A comparison of the two treatments in relation to the pollen count yielded statistically significantly fewer nasal symptoms, such as itching, secretion, and sneezing in the budesonide-treated group. Nasal blockage and ocular symptoms remained unchanged, but the use of eyedrops was significantly reduced in the methylprednisolone-treated group. Side effects of both treatments were mild and the incidence negligible. Methylprednisolone-treated patients had a significantly lower cortisol value after 7 days but still had a normal response to ACTH-stimulation. We conclude that the acute symptoms of allergic rhinitis are at least as well ameliorated by regular topical application of budesonide as by a single injection of methylprednisolone acetate. The accompanying allergic conjunctivitis may require additional treatment.
Les therapies comportementales
Authors: Mélinée Agathon
Journal: Psychotherapy and Psychosomatics (1978)

Research Articles| February 16 2010 Les thérapies comportementales Subject Area: Psychiatry and Psychology Mélinée Agathon Mélinée Agathon Clinique des maladies mentales, Service du Prof. Pichot, Paris Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1978) 29 (1-4): 316–319. https://doi.org/10.1159/000287150 Article history Published Online: February 16 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Mélinée Agathon; Les thérapies comportementales. Psychother Psychosom 31 December 1978; 29 (1-4): 316–319. https://doi.org/10.1159/000287150 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search This content is only available via PDF. 1978Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Article PDF first page preview Close Modal You do not currently have access to this content.
An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration
Authors: Sabrina M Lehmann, Christina Krüger, Boyoun Park, Katja Derkow, Karen Rosenberger, Jan Baumgart, Thorsten Trimbuch, Gina Eom, Michael Hinz, David Kaul, Piet Habbel, Roland Kälin, Eleonora Franzoni, Agnieszka Rybak, Duong Nguyen, Rüdiger Veh, Olaf Ninnemann, Oliver Peters, Robert Nitsch, Frank L Heppner, Douglas Golenbock, Eckart Schott, Hidde L Ploegh, F Gregory Wulczyn, Seija Lehnardt
Journal: Nature Neuroscience (2012)
Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway
Authors: Hui-Wen Lo, Sheng-Chieh Hsu, Mohamed Ali-Seyed, Mehmet Gunduz, Weiya Xia, Yongkun Wei, Geoffrey Bartholomeusz, Jin-Yuan Shih, Mien-Chie Hung
Journal: Cancer Cell (2005)
STUDIES ON THE PURIFICATION OF POLIOMYELITIS VIRUS
Authors: Hubert S. Loring, C. E. Schwerdt
Journal: The Journal of Experimental Medicine (1942)

Results of experiments on the preparation of high molecular weight constituents from normal and poliomyelitis-infected medullae-cords are presented. Relatively large yields were obtained from glycerolated normal or infected tissues or from tissues that had been stored at -10 degrees C. for a few days. When the frozen tissues were stored for several weeks, the amount of sedimentable nitrogen isolated from the normal cords decreased and became almost negligible. Under these same conditions small but definite amounts of a high molecular weight material were isolated from the infectious extracts. This material regularly produced poliomyelitis when 1 ml. containing 5 x 10(-9) gm. of nitrogen was injected intracerebrally into rhesus monkeys. The purified virus sediment contains nitrogen, phosphorus, and carbohydrate, it gives the Millon's test for protein, and is precipitated by one-third saturation with ammonium sulfate. Results of ultracentrifugal analyses show that a relatively homogeneous component with S(W) (20 degrees ) = 62 x 10(-13) is present.
Abstract LB-15: Enhancement of radiotherapeutic efficacy by cisplatin-incorporated bionanocapsule without nephrotoxicity
Authors: Seol Hwa Shin, Seok Soon Park, Joohee Jeong, Jinhyang Choi, Jaesook Park, Jae Hee Lee, Hye Ji Park, Si Yeol Song, Seong-Yun Jeong, Shun'ich Kuroda, Eun Kyung Choi
Journal: Cancer Research (2014)

Abstract Radiotherapy is one of the most effective tools in the clinical treatment for many types of solid tumors, but the therapeutic efficacy is often limited because of resistance to ionizing radiation. Although cisplatin (CDDP) is widely used as a radiosensitizer to improve therapeutic outcomes, its side effect such as acute nephrotoxicity limits application. To overcome the hurdle of CDDP, it is extremely necessary to apply a delivery system that can enhance the radiotherapeutic efficacy and reduce CDDP-induced side effects. Bionanocapsule (BNC) consisting of hepatitis B virus surface antigen (HBsAg) L protein is approximately 50-nm hollow particles displaying a human hepatocyte-recognizing molecule (pre-S1 peptide). BNC-liposome complex has been developed suitable to deliver drugs and genes to human hepatocytes specifically in vivo. Utilizing the character of BNC targeting hepatocytes and its property to carry anti-cancer agents, we designed a BNC complex incorporating liposomal CDDP (BNC-LP-CDDP) for hepatocellular carcinoma (HCC). HCC is the fifth most common cancer and the third most common cause of cancer related death worldwide. Although surgical resection is the optimal treatment approach, only a small proportion of patients are qualified for surgery and there is a high rate of tumor recurrence. BNC-LP-CDDP has been produced to destroy HCC without nephrotoxicity, and we aimed in this study to confirm the effect enhancing the radiotherapeutic efficacy in vitro and in vivo. The in vitro HCC-specific cytotoxicity of BNC-LP-CDDP was confirmed by comparison between human HCC Hep3B and human NSCLC A549 cells. The result of clonogenic assay to evaluate chemoradiotherapeutic efficacy of BNC-LP-CDDP demonstrated that survival fraction of hep3B showed radiosensitivity efficacy by BNC-LP-CDDP with IR. In vivo, treatment with BNC-LP-CDDP (2 mg/kg) and IR (3 Gy) delayed tumor growth accompanying increased apoptotic cell death more than that of other groups. Furthermore, BNC-LP-CDDP displayed decreased nephrotoxicity of CDDP. Collectively, our results demonstrate that BNC-LP-CDDP in combination with ionizing radiation enhanced radiotherapeutic efficacy by human liver-pinpoint delivery and eliminated CDDP-induced nephrotoxicity. Citation Format: Seol Hwa Shin, Seok Soon Park, Joohee Jeong, Jinhyang Choi, Jaesook Park, Jae Hee Lee, Hye Ji Park, Si Yeol Song, Seong-Yun Jeong, Shun'ich Kuroda, Eun Kyung Choi. Enhancement of radiotherapeutic efficacy by cisplatin-incorporated bionanocapsule without nephrotoxicity. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr LB-15. doi:10.1158/1538-7445.AM2014-LB-15
14,15-Epoxyeicosa-5( <i>Z</i> )-enoic Acid
Authors: Kathryn M. Gauthier, Christina Deeter, U. Murali Krishna, Y. Krishna Reddy, Muralidhar Bondlela, J.R. Falck, William B. Campbell
Journal: Circulation Research (2002)

Endothelium-dependent hyperpolarization and relaxation of vascular smooth muscle are mediated by endothelium-derived hyperpolarizing factors (EDHFs). EDHF candidates include cytochrome P-450 metabolites of arachidonic acid, K + , hydrogen peroxide, or electrical coupling through gap junctions. In bovine coronary arteries, epoxyeicosatrienoic acids (EETs) appear to function as EDHFs. A 14,15-EET analogue, 14,15-epoxyeicosa-5( Z )-enoic acid (14,15-EEZE) was synthesized and identified as an EET-specific antagonist. In bovine coronary arterial rings preconstricted with U46619, 14,15-EET, 11,12-EET, 8,9-EET, and 5,6-EET induced concentration-related relaxations. Preincubation of the arterial rings with 14,15-EEZE (10 μmol/L) inhibited the relaxations to 14,15-EET, 11,12-EET, 8,9-EET, and 5,6-EET but was most effective in inhibiting 14,15-EET–induced relaxations. 14,15-EEZE also inhibited indomethacin-resistant relaxations to methacholine and arachidonic acid and indomethacin-resistant and l -nitroarginine-resistant relaxations to bradykinin. It did not alter relaxation responses to sodium nitroprusside, iloprost, or the K + channel activators (NS1619 and bimakalim). Additionally, in small bovine coronary arteries pretreated with indomethacin and l -nitroarginine and preconstricted with U46619, 14,15-EEZE (3 μmol/L) inhibited bradykinin (10 nmol/L)–induced smooth muscle hyperpolarizations and relaxations. In rat renal microsomes, 14,15-EEZE (10 μmol/L) did not decrease EET synthesis and did not alter 20-hydroxyeicosatetraenoic acid synthesis. This analogue acts as an EET antagonist by inhibiting the following: (1) EET-induced relaxations, (2) the EDHF component of methacholine-induced, bradykinin-induced, and arachidonic acid–induced relaxations, and (3) the smooth muscle hyperpolarization response to bradykinin. Thus, a distinct molecular structure is required for EET activity, and alteration of this structure modifies agonist and antagonist activity. These findings support a role of EETs as EDHFs.
Influence of mitral valve morphology on double-balloon catheter balloon valvuloplasty in patients with mitral stenosis. Analysis of factors predicting immediate and 3-month results.
Authors: C L Reid, P A Chandraratna, D T Kawanishi, A Kotlewski, S H Rahimtoola
Journal: Circulation (1989)

To determine if mitral valve morphology influences the results of double-balloon catheter balloon valvuloplasty (CBV) for mitral stenosis, two-dimensional echocardiography was performed in 33 patients before CBV. The two-dimensional echocardiographic features of leaflet motion, leaflet thickness, subvalvular disease, and commissural calcium and 14 pre-CBV clinical and hemodynamic variables were then correlated to the immediately post-CBV mitral valve area (MVA). At 3 months after CBV, the two-dimensional echocardiographic features of patients with a 25% or greater decrease in MVA were analyzed to determine whether mitral valve morphology had influenced early results. Leaflet motion had a significant relation with the immediately post-CBV MVA (r = 0.67, y = 4.5x + 0.29, and SEE = 0.45). Leaflet thickness had a weak and negative relation (r = -0.48, y = -0.17x + 2.6, and SEE = 0.53) with the immediately post-CBV MVA. Subvalvular disease and commissural calcium had no significant relation to the immediately post-CBV MVA. When leaflet motion and leaflet thickness were considered as grades of mild, moderate, and severe and assigned a score of 0-2, patients with more severe disease (total score, 3 or 4) had a significant lower MVA immediately after CBV (1.4 +/- 0.4 cm2) than patients with moderate disease (score, 1-2; MVA, 2.0 +/- 0.5 cm2; p less than 0.05) or mild disease (score, 0; MVA, 2.6 +/- 0.6 cm2; p less than 0.05). In 96% of patients with a total score of 0-2, the immediately post-CBV MVA was more than 1.4 cm2, whereas only 29% of patients with a total score of 3-4 had an immediately post-CBV MVA of more than 1.4 cm2. Analysis of all two-dimensional echocardiographic features showed that leaflet motion score had the strongest influence on the post-CBV MVA (p less than 0.001). When all two-dimensional echocardiographic, clinical, and hemodynamic variables were included, leaflet motion, effective balloon dilating area, and cardiac output were the strongest predictors of the immediate post-CB MVA.(ABSTRACT TRUNCATED AT 400 WORDS)