tbuckley/cabot-search huggingface dataset:
Anthony John (“Tony”) Whitaker
Authors: P T Bull, M J Mowbray
Journal: BMJ (2006)

A pioneer in rheumatology on both sides of the Atlantic Watson Buchanan had a major influence on the development of rheumatology in Scotland and in Canada.He was the driving force that led to the creation of internationally renowned centres for rheumatic diseases in Glasgow and in Hamilton, Ontario.In 1964 Watson was appointed senior lecturer in the department of medicine at the Royal Infirmary in Glasgow and consultant in charge of the newly created Centre for Rheumatic Diseases in the refurbished old hospital in Baird Street.The centre, and the Regional Immunopathology Laboratory established within it, rapidly developed a national and international reputation for clinical excellence, postgraduate training, and research, and attracted trainees from throughout the United Kingdom and from overseas.The research output from Baird Street was huge and included groundbreaking studies of clinical and imaging indices, which were forerunners of clinical instruments currently used to assess, and follow the progress of, patients with inflammatory arthritis.Watson was the author, or coauthor, of more than 500 papers in peer reviewed journals, and some 60 contributed chapters, and he
Dr. Wohl's Violin: A Family Doctor's Last Act of Kindness
Authors: Sheldon H. Gottlieb
Journal: Annals of Internal Medicine (2007)

On Being a Doctor15 May 2007Dr. Wohl's Violin: A Family Doctor's Last Act of KindnessSheldon H. Gottlieb, MDSheldon H. Gottlieb, MDFrom Johns Hopkins Bayview Medical Center, Baltimore, MD 21224.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-146-10-200705150-00013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail It began as a typical afternoon in the coronary care unit. While trying to finish my charting so that I could get home for dinner with my family, I was paged to the CCU resident's office. In the cluttered office, I found a medical resident nervously pacing the floor. When I walked in, he brightened up and immediately launched into his presentation: “Dr. Gottlieb, we have a tough case. This is a 25-year-old white male with terminal acute myeloid leukemia who was on home hospice. But when he finally arrested, his father panicked and called 911. Now the kid's on ... Author, Article, and Disclosure InformationAuthors: Sheldon H. Gottlieb, MDAffiliations: From Johns Hopkins Bayview Medical Center, Baltimore, MD 21224.Corresponding Author: Sheldon H. Gottlieb, MD, Johns Hopkins Bayview Medical Center, 4940 Eastern Avenue, Baltimore, MD 21224; e-mail, sgottli@jhmi.edu. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 May 2007Volume 146, Issue 10 Page: 755-756 Keywords Acute myeloid leukemia Cardiac care unit Computers Emotions End of life care Hearing Knees Nurses Thorax Ventilators ePublished: 15 May 2007 Issue Published: 15 May 2007 Copyright & PermissionsCopyright © 2007 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Regression of the tumor after withdrawal of cyclosporine in relapsed extranodal natural killer/T cell lymphoma following allogeneic hematopoietic stem cell transplantation
Authors: Shinichi Kako, Koji Izutsu, Kumi Oshima, Hiroyuki Sato, Yoshinobu Kanda, Toru Motokura, Shigeru Chiba, Mineo Kurokawa
Journal: American Journal of Hematology (2007)

Abstract The prognosis of patients with advanced‐stage extranodal natural killer/T cell lymphoma, nasal type (ENKL) has been generally poor, and several anecdotal reports have suggested the role of allogeneic hematopoietic stem cell transplantation (HSCT). A potential advantage of allogeneic HSCT may be the graft‐versus‐lymphoma (GVL) effect. The susceptibility to the GVL effect, however, has been shown to vary according to histologic subtypes, and it has been hardly documented yet whether ENKL is susceptible to the GVL effect. Here we report a patient with advanced‐stage ENKL who underwent allogeneic HSCT from an HLA one‐allele mismatched related donor, whose clinical course after HSCT suggested the potent GVL effect against ENKL. A 43‐year‐old female underwent allogeneic HSCT for advanced‐stage, chemorefractory ENKL, and achieved complete response. In 4 months after the transplantation, however, the ENKL relapsed in multiple sites. These lesions markedly responded to the discontinuation of immunosuppressive agents and disappeared. Except for a temporal exacerbation of bronchiolitis obliterans organizing pneumonia, she has been free from disease for more than a year without other treatments against lymphoma. The clinical course of the current patient suggests the potent GVL effect against ENKL. Allogeneic HSCT, including that with reduced‐intensity regimens, is a promising treatment option for high‐risk ENKL. Am. J. Hematol. 82:937–939, 2007. © 2007 Wiley‐Liss, Inc.
Straight Back—A "Nonsyndrome"?
Authors: MORTON E. TAVEL
Journal: Annals of Internal Medicine (1970)

Editorial Notes1 August 1970Straight Back—A "Nonsyndrome"?MORTON E. TAVEL, M.D., F.A.C.P.MORTON E. TAVEL, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-73-2-335 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDuring the past 10 years some reports have suggested a syndrome association among an unusually straight back (loss of upper dorsal kyphosis), narrow anteroposterior chest diameter, and certain clinical findings that simulate heart disease (1, 2). These clinical findings include a pulmonary systolic ejection murmur and a widely split second heart sound that, although usually varying with respiration, occasionally remains audibly split during expiration. Splitting of the first heart sound may seem exaggerated, and one may feel a prominent and seemingly sustained outward parasternal impulse. Roentgenograms often show prominent pulmonary arteries and displacement of the heart to the left, with...References1. RAWLINGS M: The "straight back" syndrome, a new cause of pseudoheart disease. Amer J Cardiol 5:333-538, 1960 CrossrefMedlineGoogle Scholar2. DE LEONPERLOFFTWIGG AJH: The straight back syndrome: clinical cardiovascular manifestations. Circulation 32:193-203, 1965 CrossrefMedlineGoogle Scholar3. EHLERSENGLEFARNSWORTH KMP: Wide splitting of the second heart sound without demonstratable heart disease. Amer J Cardiol 23:690-696, 1969 CrossrefMedlineGoogle Scholar4. WENNEVOLDSTAGE AP: The "straight back syndrome" related to intracardiac murmurs. Danish Med Bull 17:24-27, 1970 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Indiana University Medical Center Indianapolis, Ind. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe “straight back” syndrome: Current perspective more often associated with valvular heart disease than pseudoheart disease: A prospective clinical, electrocardiographic, roentgenographic, and echocardiographic study of 50 patients. 1 August 1970Volume 73, Issue 2Page: 335-336KeywordsCardiovascular therapyHeartKyphosisPulmonary arteriesRespirationSystolic ejection murmurThorax Issue Published: 1 August 1970 PDF downloadLoading ...
Straw-men and selective citation are needed to argue that associative-link formation makes no contribution to human learning
Authors: Dominic M. Dwyer, Michael E. Le Pelley, David N. George, Mark Haselgrove, Robert C. Honey
Journal: Behavioral and Brain Sciences (2009)

Abstract Mitchell et al. contend that there is no need to posit a contribution based on the formation of associative links to human learning. In order to sustain this argument, they have ignored evidence which is difficult to explain with propositional accounts; and they have mischaracterised the evidence they do cite by neglecting features of these experiments that contradict a propositional account.
CARDIAC 123 I-MIBG SCINTIGRAPHY COMBINED WITH MYOCARDIAL PERFUSION IMAGING IDENTIFIES HEART FAILURE PATIENTS AT LOW RISK FOR SERIOUS ARRHYTHMIC EVENTS: INSIGHTS FROM ADMIRE-HF STUDY
Authors: Firas J. Al Badarin, Alan Wimmer, Kevin Kennedy, Timothy Bateman
Journal: Journal of the American College of Cardiology (2012)
Peritoneal Access Device for Dialysis
Authors: Robert A. Ersek
Journal: JAMA (1971)

<h3>To the Editor. —</h3> I read with great interest the article by Vidt et al entitled "A Safe Peritoneal Access Device for Repeated Peritoneal Dialysis" (<b>214</b>:2293, 1970), and would like to relay the work that we have been doing at the University of Minnesota with a chronic peritoneal dialysis access device. They have gained repeated access safely by the instillation of a Teflon rod through the peritoneal wall to create a fistulous tract for the peritoneal catheter to be placed. We have approached the problem for the same reasons, but have derived a different technique using a mushroom-shaped, hollow silicone rubber reservoir with a stainless steel disk, as in Fig 1. The dome of the mushroom-shaped reservoir is of a thick (3 mm) 90 durometer surgical grade silicone rubber and allows for multiple repeated functions with self-sealing, much as a self-sealing inner tube functions. The shaft of the mushroom
Expression and Regulation of ST2, an Interleukin-1 Receptor Family Member, in Cardiomyocytes and Myocardial Infarction
Authors: Ellen O. Weinberg, Masahisa Shimpo, Gilles W. De Keulenaer, Catherine MacGillivray, Shin-ichi Tominaga, Scott D. Solomon, Jean-Lucien Rouleau, Richard T. Lee
Journal: Circulation (2002)

We identified an interleukin-1 receptor family member, ST2, as a gene markedly induced by mechanical strain in cardiac myocytes and hypothesized that ST2 participates in the acute myocardial response to stress and injury.ST2 mRNA was induced in cardiac myocytes by mechanical strain (4.7+/-0.9-fold) and interleukin-1beta (2.0+/-0.2-fold). Promoter analysis revealed that the proximal and not the distal promoter of ST2 is responsible for transcriptional activation in cardiac myocytes by strain and interleukin-1beta. In mice subjected to coronary artery ligation, serum ST2 was transiently increased compared with unoperated controls (20.8+/-4.4 versus 0.8+/-0.8 ng/mL, P<0.05). Soluble ST2 levels were increased in the serum of human patients (N=69) 1 day after myocardial infarction and correlated positively with creatine kinase (r=0.41, P<0.001) and negatively with ejection fraction (P=0.02).These data identify ST2 release in response to myocardial infarction and suggest a role for this innate immune receptor in myocardial injury.
Frederick Albert Cook (1865–1940)
Authors: Nathan P. Couch
Journal: New England Journal of Medicine (1956)

DOCTORS Afield, if considered a phylum of the medical kingdom, can be subdivided into two classes: aberrant physicians who still cling to some form of medical practice, and those who do not. Dr. Frederick A. Cook, first in the former group and later in the latter, was an ill starred, infinitely ambitious Brooklyn general practitioner who took up exploring and, as a consequence, became probably the most controversial figure in twentieth-century Arctic history.Born and raised in the Catskill Mountains, where he developed an early taste for hard winters, he spent his adolescence and collegiate years in New York City. . . .
Pylotis Gan Stuart Sutton
Authors: N. Fisher
Journal: BMJ (2013)

Pylotis Gan Stuart Sutton (“Pylo”) was born into a medical family. His father was a general practitioner in London’s East End, and his three older brothers all practised in various medical disciplines. After qualifying Pylo worked as a house officer at the Princess Alice Hospital in Eastbourne, followed by National Service in the Royal …
Regulation of murine fetal-placental calcium metabolism by the calcium-sensing receptor.
Authors: C S Kovacs, C L Ho-Pao, J L Hunzelman, B Lanske, J Fox, J G Seidman, C E Seidman, H M Kronenberg
Journal: Journal of Clinical Investigation (1998)

The calcium-sensing receptor (CaSR) regulates PTH secretion to control the extracellular calcium concentration in adults, but its role in fetal life is unknown. We used CaSR gene knockout mice to investigate the role of the CaSR in regulating fetal calcium metabolism. The normal calcium concentration in fetal blood is raised above the maternal level, an increase that depends upon PTH-related peptide (PTHrP). Heterozygous (+/-) and homozygous (-/-) disruption of the CaSR caused a further increase in the fetal calcium level. This increase was modestly blunted by concomitant disruption of the PTHrP gene and completely reversed by disruption of the PTH/ PTHrP receptor gene. Serum levels of PTH and 1, 25-dihydroxyvitamin D were substantially increased above the normal low fetal levels by disruption of the CaSR. The free deoxypyridinoline level was increased in the amniotic fluid (urine) of CaSR-/- fetuses; this result suggests that fetal bone resorption is increased. Placental calcium transfer was reduced, and renal calcium excretion was increased, by disruption of the CaSR. These studies indicate that the CaSR normally suppresses PTH secretion in the presence of the normal raised (and PTHrP-dependent) fetal calcium level. Disruption of the CaSR causes fetal hyperparathyroidism and hypercalcemia, with additional effects on placental calcium transfer.
METABOLIC AND IMMUNOLOGICAL EFFECTS OF CYCLOSPORIN IN RECENTLY DIAGNOSED TYPE 1 DIABETES MELLITUS
Authors: R. Assan, M. Debray-Sachs, C. Laborie, L. Chatenoud, G. Feutren, M.C. Quiniou-Debrie, G. Thomas, J.F. Bach
Journal: The Lancet (1985)
Suppurative Gonococcal Arthritis
Authors: Norman F. Jacobs
Journal: JAMA (1976)

RECENT reports have emphasized the occurrence of gonococcal arthritis in sexually active young adults.<sup>1-4</sup>However, since joint destruction may result from delayed or inappropriate therapy, physicians should be aware that this disease may occur in older patients. This report describes a case of suppurative gonococcal arthritis in a 62-year-old woman. <h3>Report of a Case</h3> A 62-year-old widow was well until six weeks before admission, when she fell, sustaining blunt injury to her left knee and abrasions of her hands. The next day a physician gave her an injection of penicillin and four penicillin tablets. The abrasions improved, but pain and swelling of the left knee persisted, causing difficulty in walking. Two weeks before admission she felt a chill, but had no rigor or fever. Following this, pain and swelling of the knee became progressively worse. She denied sore throat, skin lesions, drug ingestion, dysuria, vaginal discharge, other joint problems,
Host-microbiota interactions in inflammatory bowel disease
Authors: Charles O. Elson, Yingzi Cong
Journal: Gut Microbes (2012)

The interaction of the host with its abundant intestinal microbiota is complex and engages most of the cells in the intestinal mucosa. The inflammatory bowel diseases appear to be disorders of the host immune response to the microbiota. This is supported by data from induced gene mutations in mice and more recently by the identification of gene variants in humans that result in IBD or IBD susceptibility. These genetic studies have provided insights into the cells and molecular pathways involved in the host-microbiota dialog. This review discusses the innate, adaptive, and regulatory immune response to the microbiota in the context of the mouse and human genes that are involved in maintaining intestinal homeostasis and preventing inflammation. These data continue to support the hypothesis that inflammatory bowel disease results from a dysregulated adaptive immune response, particularly a CD4 T-cell response, to the microbiota. The microbiota itself is an active participant in these homeostatic processes. The microbiota composition is perturbed during inflammation, resulting in a dysbiosis that may induce or perpetuate inflammation. However, host genotype and the environment have a major impact on the shape of such dysbiosis, as well as upon which members of the microbiota stimulate pathogenic immune responses.
Insulin regulation of protein translation repressor 4E-BP1, an eIF4E-binding protein, in renal epithelial cells
Authors: Basant K. Bhandari, Denis Feliers, Senthil Duraisamy, Jennifer L. Stewart, Anne-Claude Gingras, Hanna E. Abboud, Goutam Ghosh Choudhury, Nahum Sonenberg, Balakuntalam S. Kasinath
Journal: Kidney International (2001)
Interim results of a pilot study demonstrating the early effects of the PPAR-γ ligand rosiglitazone on insulin sensitivity, aminotransferases, hepatic steatosis and body weight in patients with non-alcoholic steatohepatitis
Authors: Brent A. Neuschwander-Tetri, Elizabeth M. Brunt, Kent R. Wehmeier, Craig A. Sponseller, Karen Hampton, Bruce R. Bacon
Journal: Journal of Hepatology (2003)
Do Frail, Disabled, Poor, and Very Old Medicare Beneficiaries Have Higher Hospital Charges?
Authors: Stephen F. Jencks
Journal: JAMA (1987)

To determine whether basing payments on diagnosis related groups (DRGs) results in mispayment for certain classes of patients, we examined the relation between total Medicare charges per hospitalization and eight beneficiary characteristics (including admission from a nursing home, extreme age, Medicaid enrollment, and disability). We controlled for the hospital in which care was given and the DRG to which the discharge was assigned. The largest effects were that average charges were 6.7% higher for beneficiaries who were disabled before the age of 65 years, and 6.2% higher for patients admitted from a nursing home; charges were 1.5% lower for Medicare beneficiaries who were also enrolled in Medicaid, 3.8% higher for those older than 80 years, and 1.3% lower for those older than 85 years compared with those aged from 80 to 84 years. Because these differences are very small compared with the average variation within DRGs, we conclude that using these beneficiary characteristics in the DRG classification system would only slightly improve DRGs. Medicare's DRG-based payments seem to be substantially equitable with regard to these beneficiary characteristics. (<i>JAMA</i>1987;257:198-202)
Prostate cancer treatment ascertained from several sources: analysis of disagreement and error
Authors: M. Goodman, N.K. Steenland, M.L. Almon, J.S. Liff, C.K. Dilorio, S.O. Butler, D.U. Ekwueme, I.J. Hall, J. Lee Smith, V.A. Master, P.L. Roberts
Journal: Annals of Oncology (2011)
On Ligature of the Femoral Artery According to the Plan of the Late Professor Porter
Authors: R. Macnamara
Journal: BMJ (1867)

dxilla be quite healthy,-the diagnosis becomes a certainty, and an adenoid tumour may with confidence be pronounced to exist.With these remarks upon the diagnosis of the adenoid or innocent tumour of the breast-a form of tumour which, you will have observed, has but little connexion with the breast itself, and is not a disease of the true gland-I must close my present lecture, leaving the consideration of the diagnosis of a tumour which is evidently situated in the gland itself for consideration at our next meeting.
Another lesson from the Japan Medical Association
Authors: Masamine Jimba
Journal: BMJ (2005)

Save the FDAEditor-Abbasi asks whether drug regulation is failing. 1 The US Food and Drug Administration (FDA) performs a thankless task.Patients want new drugs available immediately and agitate to accomplish this.Patients also wish medicines to be guaranteed safe, and blame the FDA when toxicity leads to a drug's withdrawal.Clinical scientists complain that the FDA obstructs their investigations.Pharmaceutical companies see the FDA as an adversary, not a protector.Practising in the USA for 20 years, I encountered many FDA agents.A few revered regulations for their own sake.Such people are irksome, but without strict oversight valueless and toxic agents would be marketed.A prime example is Laetrile (laevo-mandelonitrile-beta-glucuronoside), a useless and poisonous drug promoted for cancer treatment.The FDA, supported by the National Cancer Institute, successfully resisted extreme public pressure to allow its marketing, saving many lives and a multimillion dollar fraud.The FDA faces serious accusations.Attempting to suppress David Graham's whistleblowing on rofecoxib assaults scientific honesty. 2 3 The FDA's refusal to allow non-prescription sales of emergency contraception indicates unacceptable political pressure from the religious right.Unduly close relations between the FDA and pharmaceutical companies may lead to premature marketing approvals.How should the FDA be saved?Firstly, officials ordering withdrawal of a drug should be independent of those who approve marketing.Secondly, making the FDA a quango would protect from political pressures.Thirdly, conflicts of interest involving FDA employees and consultants must be rigorously scrutinised, even more severely than editors scrutinise the interests of contributors.The UK's Medicines and Healthcare products Regulatory Agency is accused of proindustry bias.Housecleaning there and at the FDA will benefit patients, doctors, and the pharmaceutical industry itself.
Overexpression of 12-Lipoxygenase Causes Cardiac Fibroblast Cell Growth
Authors: Yeshao Wen, Jiali Gu, Yaxia Liu, Ping H. Wang, Yanyu Sun, Jerry L. Nadler
Journal: Circulation Research (2001)

Abstract —Evidence suggests that leukocyte type 12-lipoxygenase (12-LO) plays an important role in cell growth. However, the role of 12-LO in cardiac cell growth has not been tested. We have now stably overexpressed 12-LO cDNA in rat fetal cardiac fibroblasts to evaluate the role of the 12-LO pathway in cardiac cell growth. Overexpression of 12-LO increased cell [ 3 H]leucine incorporation by 2.1±0.1-fold ( P &lt;0.01) and cell protein content by 2.2±0.3-fold ( P &lt;0.01) over mock-transfected cells. These findings were confirmed in additional clones. Baicalein, a 12-LO enzyme inhibitor, dose-dependently inhibited serum-induced leucine incorporation in cardiac fibroblast cells as well as partially inhibited leucine incorporation in cells overexpressing 12-LO. 12-LO overexpression also caused cell [ 3 H]thymidine incorporation to increase by 3.4±0.3-fold ( P &lt;0.01). Cell flow cytometry analysis showed that the size of 12-LO–overexpressing cells was markedly enlarged compared with that of mock-transfected cells. The fibronectin content of the 12-LO–overexpressing cardiac fibroblasts was also significantly increased. We next evaluated the effects of 12-LO RNA overexpression on kinase pathways linked to cellular growth. The overexpression of 12-LO enhanced extracellular signal-regulated kinase activity (4.1±0.5-fold), c-Jun NH 2 -terminal kinase activity (2.9±0.5-fold), and p38 mitogen-activated protein kinase activity (2.2±0.3-fold). Pretreatment with SB202190 (100 nmol/L), a specific inhibitor of p38, prevented the increases in protein content of 12-LO–overexpressing cardiac fibroblast cells. These data clearly demonstrate that the overexpression of 12-LO causes cell growth of cardiac fibroblasts, thus supporting the role of 12-LO as a novel growth-promoting pathway in the heart.