Malignant Glucagonoma Syndrome: Response to Chemotherapy
Authors: Samuel P. Marynick, Warren R. Fagadau, Lewis A. Duncan
Journal: Annals of Internal Medicine (1980)

Brief Reports1 September 1980Malignant Glucagonoma Syndrome: Response to ChemotherapySAMUEL P. MARYNICK, M.D., WARREN R. FAGADAU, M.D., LEWIS A. DUNCAN, M.D.SAMUEL P. MARYNICK, M.D.Search for more papers by this author, WARREN R. FAGADAU, M.D.Search for more papers by this author, LEWIS A. DUNCAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-93-3-453 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe glucagonoma syndrome has been the subject of recent papers (1-7) that have dealt with descriptions of the glucagonoma syndrome (1, 2), observations as to the mechanism of the characteristic glucagonoma skin rash (3, 4), or have been reports of successful or unsuccessful chemotherapy (1, 5-7). We describe here the third reported case where dimethyltriazenoimidazole carboxamide (dacarbazine) has produced clinical remission in a metastatic alpha-cell pancreatic tumor.A 59-year-old woman presented in July 1977 with skin rash and vomiting. Medical evaluation revealed a pancreatic tumor. Plasma glucagon level was "15 times normal" preoperatively. At surgery an islet-cell tumor was found...References1. MALLINSONBLOOMWARINSALMONCOX CSAPB. Glucagonoma syndrome. Lancet. 1974;2:1-5. CrossrefMedlineGoogle Scholar2. BINNICKSPENCERDENNISONHORTON ASWE. Glucagonoma syndrome: report of two cases and literature review. Arch Dermatol. 1977;113:749-54. CrossrefMedlineGoogle Scholar3. KAHANPEREZ-FIGAREDONEIMANIS RRA. Necrolytic migratory erythema: distinctive dermatosis of the glucagonoma syndrome. Arch Dermatol. 1977;113:792-7. CrossrefMedlineGoogle Scholar4. NORTONKAHNSCHIEBINGERGORSCHBOTHBRENNAN JCRCM. Amino acid deficiency and the skin rash associated with glucagonoma. Ann Intern Med. 1979;91:213-5. LinkGoogle Scholar5. DANFORTHTRICHEDOPPMANBEAZLEYPERRINORECANT DTJRPL. Elevated plasma proglucagon-like component with a glucagon-secreting tumor: effect of streptozotocin. N Engl J Med. 1976;295:242-5. CrossrefMedlineGoogle Scholar6. STRAUSSWEITZMANAOKI GST. Dimethyltriazenoimidazole carboxamide therapy of malignant glucagonoma. Ann Intern Med. 1979;90:57-8. LinkGoogle Scholar7. KESSINGERLEMONFOLEY AHJ. The glucagonoma syndrome and its management. J Surg Oncol. 1977;9:419-24. CrossrefMedlineGoogle Scholar8. UNGERAGUILAR-PARADAMÜLLEREISENTRAUT REWA. Studies of pancreatic alpha cell function in normal and diabetic subjects. J Clin Invest. 1970;49:837-48. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: SAMUEL P. MARYNICK, M.D.; WARREN R. FAGADAU, M.D.; LEWIS A. DUNCAN, M.D.Affiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNeuroendocrine TumorsEndokrine Tumoren des gastroenteropankreatischen SystemsEndocrine PancreasKetoacidosis and Hyperosmolar ComaMultiple Endocrine Neoplasia Type 1A case of malignant pancreatic endocrine tumor with marked response to systemic chemotherapy with dacarbazineMolecular genetics and patient management of multiple endocrine neoplasia type 1MULTIPLE ENDOCRINE NEOPLASIA TYPE 1A Case of Glucagonoma with Liver Metastasis: Complete Response to DacarbazineDiabetic Ketoacidosis in a Patient With GlucagonomaAnatomic distribution of pancreatic endocrine tumorsTherapeutic strategies in the management of endocrine GEP tumoursSystemic and Regional Therapy of Advanced Islet Cell TumorsTherapy of the Malignant Carcinoid Syndrome and Metastatic Islet Cell CarcinomaTumors of the Gastroenteropancreatic AxisMetastatic medullary thyroid carcinoma: Complete response to combination chemotherapy with dacarbazine and 5-fluorouracilMetastatic islet cell amphicrine carcinoma of the pancreas: Association with an eosinophilic infiltration of the skin10 Multiple endocrine neoplasiaNonfunctioning islet cell carcinoma of the pancreas complete response to continuous 5-fluorouracil infusionGlucagonoma, A Rare Cause of Obstructive Jaundice: Report of a CasePankreaskarzinomRetrobulbar neuritis as the first sign of the glucagonoma syndromeA glucagon-secreting pancreatic alpha islet cell tumor presenting as spinal cord compressionChemotherapy of metastatic carcinoid and islet cell tumors: A reviewSuccessful treatment of glucagonoma-related necrolytic migratory erythema with dacarbazineA functional study of a case of glucagonoma exhibiting typical glucagonoma syndromeNeuroendocrine Tumours of the Gut: Long-Term Therapy with the Somatostatin Analogue SMS 201-995Effect of streptozotocin in a case of glucagon-secreting malignant islets-cell tumorEndocrine tumors of the gastroenteropancreatic axisMultiple endocrine neoplasia syndromesTherapy of malignant APUD cell tumors: Effectiveness of DTICUnsuccessful DTIC treatment of a Patient with Glucagonoma SyndromeThe Glucagonoma SyndromeGlucagonoma and DacarbazineLEWIS A. DUNCAN, M.D., SAMUEL P. MARYNICK, M.D. 1 September 1980Volume 93, Issue 3Page: 453-454KeywordsBlood plasmaChemotherapyGlucagonRashesSurgeryVomiting ePublished: 1 December 2008 Issue Published: 1 September 1980 PDF downloadLoading ...