tbuckley/cabot-search huggingface dataset:
Increased Ca2+ sensitivity of contractile elements via protein kinase C in α-toxin permeabilized SMA from young spontaneously hypertensive rats
Authors: Hisashi Sasajima, Hiroki Shima, Yasuaki Toyoda, Keizo Kimura, Akiyoshi Yoshikawa, Takuzo Hano, Ichiro Nishio
Journal: Cardiovascular Research (1997)

The purpose of the present investigation was to examine the Ca2+ sensitivity of the contractile elements via protein kinase C (PKC) in superior mesenteric artery (SMA) from young (5-6 weeks old) spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY).Staphylococcal aureus alpha-toxin, which produces pores in the plasma membrane too small to allow passage of proteins such as PKC, was used to investigate the signal transduction system in vascular smooth muscle cells. We investigated the Ca2+ sensitivity of the contractile apparatus via PKC in intact and alpha-toxin skinned SMA from young SHR and WKY.In intact SMA, high K+ responses were not different between SHR and WKY. However, phorbol 12,13-dibutyrate (PDBu, a PKC activator) augmented high K(+)-evoked contractions and PKC inhibitors, such as 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H-7) and calphostin C, suppressed them more in SHR as compared with WKY. In alpha-toxin skinned SMA, the [Ca2+]i-force relationship curve was not significantly different between SHR and WKY. However, PDBu augmented [Ca2+]i-evoked contractions and PKC inhibitors suppressed them more in SHR than in WKY.These results suggest that the Ca2+ sensitivity of the contractile elements via PKC is significantly greater in prehypertensive SHR than in age-matched WKY. This abnormality in small muscular arteries may be involved in the pathogenesis of hypertension in SHR.
A sinister cause of shoulder pain, with numbness and weakness in the ipsilateral hand
Authors: R. Popat, J. Derodra, S. Vig, E. Lim
Journal: BMJ (2012)

A 41 year old patient with insulin dependent diabetes presented with a one month history of progressively worsening pain, numbness, and weakness of his right shoulder and arm. His history included peripheral vascular disease, chronic renal failure, and chronic pancreatitis. He was also a smoker with a 60 pack year history.

On general inspection, he appeared cachectic. On closer inspection of the right upper limb, he had wasting of the intrinsic muscles of the hand. Finger abduction and adduction in the right hand was weak, as was flexion of the right ring finger and right little finger. Tone and reflexes were normal; however, sensation along the right little finger and the ulnar aspect of the upper limb on the right side was reduced. On examination, his elbow and shoulder were normal.

He underwent chest radiography (fig 1⇓), followed by computed tomography of his chest and abdomen.



Fig 1 Anteroposterior radiograph of our patient’s chest





### 1 What are the radiological findings?

#### Short answer

The radiograph shows an area of opacification in the right lung apex but is otherwise normal.

#### Long answer

The chest radiograph shows an area of opacification in the right lung apex but is otherwise normal (fig 2⇓).



Fig 2 Anteroposterior radiograph showing an area …
Contributory negligence. 2
Authors: A. R. Holder
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The predictive value of stable precursor fragments of vasoactive peptides in patients with chronic heart failure: data from the GISSI‐heart failure (GISSI‐HF) trial
Authors: Serge Masson, Roberto Latini, Emanuele Carbonieri, Luciano Moretti, Maria Grazia Rossi, Santo Ciricugno, Valentina Milani, Roberto Marchioli, Joachim Struck, Andreas Bergmann, Aldo P. Maggioni, Gianni Tognoni, Luigi Tavazzi
Journal: European Journal of Heart Failure (2010)
Doctors are urged to be alert to signs of child sexual exploitation
Authors: J. Wise
Journal: BMJ (2014)

Doctors are being urged to look out for possible signs of sexual exploitation of children and to refer any concerns promptly, in new guidance from the UK Academy of Medical Royal Colleges.1

The Department of Health for England asked the academy to examine what the royal medical colleges could do to help tackle the problem of child sexual exploitation, after a series of high profile cases in Rotherham …
Class Ia Antiarrhythmic Drug Cibenzoline
Authors: Mareomi Hamada, Yuji Shigematsu, Shuntaro Ikeda, Yuji Hara, Hideki Okayama, Koji Kodama, Takaaki Ochi, Kunio Hiwada
Journal: Circulation (1997)

Background The class Ia antiarrhythmic drug disopyramide relieves the outflow tract obstruction of hypertrophic obstructive cardiomyopathy (HOCM). Disopyramide, however, has several adverse effects, such as dysuria and thirst, resulting from its anticholinergic activity. A new class Ia antiarrhythmic drug, cibenzoline, has little anticholinergic activity. The aim of this study is to elucidate whether cibenzoline attenuates left ventricular pressure gradient (LVPG) in patients with HOCM. Methods and Results Ten patients with HOCM (mean age, 59±12 years) participated in this study. LVPG and left ventricular functions were measured before and 2 hours after administration of a single oral dose of 150 or 200 mg cibenzoline. LVPG decreased from 123±60 to 39±33 mm Hg ( P =.0026). The E/A ratio in transmitral Doppler flow increased from 1.20±0.84 to 2.00±1.72 ( P =.029). Isovolumic relaxation time increased from 73±16 to 101±23 ms ( P =.0026). Left ventricular diastolic dimension remained unchanged, but left ventricular systolic dimension enlarged significantly, from 21.6±2.4 to 26.2±3.3 mm ( P =.0004). Fractional shortening decreased from 47.6±6.1% to 34.6±8.8% ( P =.0007). Left ventricular ejection time index decreased significantly, and preejection period index increased in all the patients. Decreased LVPG remained maintained even in the long-term treatment with cibenzoline. Conclusions These results indicate that cibenzoline can markedly attenuate LVPG in patients with HOCM. A decrease in myocardial contractility seems to be closely related to a marked decrease in LVPG.
Third-party Mesenchymal Stem Cells Improved Human Islet Transplantation in a Humanized Diabetic Mouse Model
Authors: Hao Wu, Di Wen, Ram I Mahato
Journal: Molecular Therapy (2013)

Human islet transplantation can be a permanent treatment of type 1 diabetes if the immune rejection and primary nonfunction (PNF) of transplanted islet grafts were properly addressed. In this study, we determined whether cotransplantation of human bone marrow-derived mesenchymal stem cells (hBMSCs) could prevent immune rejection and improve human islet transplantation in a humanized NOD scid gamma (NSG) mouse model. Human immunity was rebuilt and maintained in NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) mice up to 13 weeks after intraperitoneal injection of mature human peripheral blood mononuclear cells (PBMCs). The blood glucose control and the levels of serum insulin and c-peptide clearly indicated a better outcome of islet transplantation when islets were cotransplanted with hBMSCs. hBMSCs actively interacted with interleukin-10 (IL-10)-producing CD14+ monocytes to suppress the proliferation and activation of T cells in the PBMC/hBMSC coculture and prevent the T cell recruitment into the transplantation site. hBMSCs also increased the percentage of immunosuppressive regulatory T cells (Tregs) and prevented the cytokine-induced loss-of-function of human islets. Taken together, our studies demonstrated that transplantation of islets with hBMSCs is a promising strategy to improve the outcome of human islet transplantation. Human islet transplantation can be a permanent treatment of type 1 diabetes if the immune rejection and primary nonfunction (PNF) of transplanted islet grafts were properly addressed. In this study, we determined whether cotransplantation of human bone marrow-derived mesenchymal stem cells (hBMSCs) could prevent immune rejection and improve human islet transplantation in a humanized NOD scid gamma (NSG) mouse model. Human immunity was rebuilt and maintained in NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) mice up to 13 weeks after intraperitoneal injection of mature human peripheral blood mononuclear cells (PBMCs). The blood glucose control and the levels of serum insulin and c-peptide clearly indicated a better outcome of islet transplantation when islets were cotransplanted with hBMSCs. hBMSCs actively interacted with interleukin-10 (IL-10)-producing CD14+ monocytes to suppress the proliferation and activation of T cells in the PBMC/hBMSC coculture and prevent the T cell recruitment into the transplantation site. hBMSCs also increased the percentage of immunosuppressive regulatory T cells (Tregs) and prevented the cytokine-induced loss-of-function of human islets. Taken together, our studies demonstrated that transplantation of islets with hBMSCs is a promising strategy to improve the outcome of human islet transplantation.
The effect of lipid nanoparticle PEGylation on neuroinflammatory response in mouse brain
Authors: Ji-yun Huang, Ying-mei Lu, Huan Wang, Jun Liu, Mei-hua Liao, Ling-juan Hong, Rong-rong Tao, Muhammad Masood Ahmed, Ping Liu, Shuang-shuang Liu, Kohji Fukunaga, Yong-zhong Du, Feng Han
Journal: Biomaterials (2013)
ELEPHANTIASIS OF SCROTUM AND PENIS WITH OPERATION
Authors: RAYMOND RUSS
Journal: JAMA (1910)

The following case history is presented because of the rarity of this condition on the Pacific coast. Tropical diseases about the Bay of San Francisco are rapidly increasing in number, and the practitioner must be on the constant lookout for them. <h3>History.—</h3> A young man, aged 30, single, a cigar-maker by occupation, was referred to me for extensive swelling of the penis and scrotum. This patient had been in Mexico in 1900 for three months, and in 1902 for a period of six months. There was no other history of tropical exposure. He stated that the disease appeared insidiously and had never been accompanied by pain. There had never been periods of chill, high temperature or diaphoresis, but he said that at times there had been local heat in the scrotum, although unaccompanied by general fever. <h3>Examination.—</h3> The scrotum was found to be very large, about the size of a
Sequence Evidence for Sporadic Intergeneric DNA Introgression from Wheat into a Wild Aegilops Species
Authors: Sarit Weissmann, Moshe Feldman, Jonathan Gressel
Journal: Molecular Biology and Evolution (2005)

Introgressive hybridization has played a crucial role in the evolution of many plant species, especially polyploids. The duplicated genetic material and wide geographical distribution facilitate hybridization and introgression among polyploid species having either homologous or homoeologous genomes. Such introgression may lead to the production of recombinant genomes that are more difficult to form at the diploid level. Crop genes that have introgressed into wild relatives can increase the capability of the wild relatives to adapt to agricultural environments and compete with crops or to compete with other wild species. Although the transfer of genes from crops into their conspecific immediate wild progenitors has been reported, little is known about spontaneous gene movement from crops to more distantly related species. We describe recent spontaneous DNA introgression from domesticated polyploid wheat into distantly related, wild tetraploid Aegilops peregrina (syn. Aegilops variabilis) and the stabilization of this sequence in wild populations despite not having homologous chromosomes. Our results show that DNA can spontaneously introgress between homoeologous genomes of species of the tribe Triticeae and, in the case of crop-wild relatives, possibly enrich the wild population. These results also emphasize the need for fail-safe mechanisms in transgenic crops to prevent gene flow where there may be ecological risks.
Hepatitis after Isoniazid Administration
Authors: C. Edwin Martin, John B. Arthaud
Journal: New England Journal of Medicine (1970)

ALTHOUGH isoniazid (INH) is thought to be a rare cause of jaundice its precise role is unclear. The patients in most cases reported have also been receiving another antituberculous drug such as para-aminosalicylic acid (PAS), which is a well known potential hepatotoxin.1 We recently studied a patient in whom hepatitis developed shortly after he began taking INH for a recent tuberculin skin-test (PPD) conversion. Challenge with INH was followed by a recurrence of hepatitis that was confirmed by histologie study.Case ReportA 40-year-old merchant seaman, who had formerly been in good general health, was admitted to the Alaska Native . . .
Injury Coding and Hospital Discharge Data
Authors: Joseph E. Sniezek
Journal: JAMA (1989)

Data are currently inadequate to develop, implement, and evaluate injury prevention and control programs in the United States. Information about cause of injury, which is available for fatal injuries, is rarely available for severe nonfatal injuries. Although hospital discharge data systems contain much of the important information needed for injury prevention and control programs, they rarely are coded with information about the external cause of injury (E codes). E-coded hospital discharge data systems are potentially one of the most effective and feasible means available to collect data needed to prevent and control injuries. We recommend that E codes be required elements in hospital discharge data systems, that separate fields for E codes be created, and that E-code definitions and guidelines be developed. (<i>JAMA</i>. 1989;262:2270-2272)
Depressed lymphocyte transformation by yersinia and Escherichia coli in yersinia arthritis.
Authors: R Leino, R Vuento, S Koskimies, M Viander, A Toivanen
Journal: Annals of the Rheumatic Diseases (1983)

Lymphocyte transformation responses were studied in 21 patients with acute yersinia infection followed-up after the acute infection for up to one year. Eight patients had reactive arthritis caused by yersinia. The responses to the causative serotype of yersinia were significantly lower (p less than 0.05) in patients with arthritis than in those without arthritis. Stimulation with Escherichia coli gave lower responses than with yersinia, but with E. coli the difference between arthritic and nonarthritic groups was more significant (p less than 0.02). The responses to yersinia and E. coli were not correlated with the presence of HLA B27. Lymphocyte transformation by purified protein derivative of tuberculin, streptokinase-streptodornase, phytohaemagglutinin, or concanavalin-A revealed no significant differences between the arthritic and nonarthritic groups. The role of the enterobacterial common antigen in the pathogenesis of reactive arthritis and ankylosing spondylitis is discussed.
Number of Children With Sickle Cell Anemia Increasing Worldwide
Authors: M. J. Friedrich
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Role of scientific data in health decisions.
Authors: S W Samuels
Journal: Environmental Health Perspectives (1979)

The distinction between reality and models or methodological assumptions is necessary for an understanding of the use of data--economic, technical or biological--in decision-making. The traditional modes of analysis used in decisions are discussed historically and analytically. Utilitarian-based concepts such as cost-benefit analysis and cannibalistic concepts such as "acceptable risk" are rejected on logical and moral grounds. Historical reality suggests the concept of socially necessary risk determined through the dialectic process in democracy.
THE DESIGN OF DIRECT PEDICLE FLAPS
Authors: H. D. Gillies
Journal: BMJ (1932)

JOURNAL~~~~~~~~~condition.The lesions in the area where the eruption was confluent showed some tendency to ulcerate, but ultimately complete healing took place and the patient was discharged on July 30th wvithout any complications having occurred.There also appeared to be some diminution in the size of the enlarged glands in the axillae at the time of her discharge.As far as I have been able to ascertain from a fairly extensive investigation of the literature, this patient appears to be the oldest one in whom varicella has occurred, though doubtless older persons have been attacked without their histories having been reported.
Hospital Dust: Light as a Hygienic Safeguard
Authors: L. P. Garrod
Journal: BMJ (1944)

Dust has been recognized as a vehicle of infection for many years, but preoccupation with "droplet" spread has obscured its true importance until recent times.The first of a series of modern studies revealing the actual infectivity of dust was that of Cruickshank (1935), who found that haemolytic streptococci could readily be culti- vated from the air and dust in the burn wards of the Glas- gow Royal Infirmary, where most of the patients were infected by these organisms.Elizabeth White (1936), work- ing with Colebrook at Queen Charlotte's Hospital, showed that dust in single rooms used for patients with strepto- coccal puerperal fever contained the same streptococcus, and that sweeping and bed-making increased the numbers recoverable in plates exposed to the air.In one such room these proceedings were carried on for experimental pur- poses after the patient had left it, and the sweeper developed a throat infection due to the same type of streptococcus.It was also shown that streptococci in artificially infected dust will survive for 10 weeks, and that their mouse virulence is undiminished after 25 days.The infectivity of dust is also evident from the observations made by Brown and Allison (1937) in scarlet-fever wards.Diphtheria bacilli may also exist in floor dust in large numbers in the neighbourhood of infected patients; Crosbie and Wright (1941), who demonstrated this, also found that this organism can survive in stored dust, retaining its virulence, for as long as 102 days.
A Critique of Contributions to the Alexithymia Symposium
Authors: Ira M. Lesser
Journal: Psychotherapy and Psychosomatics (1985)

This paper reviews the contributions of <i>Paulson</i>, <i>Demers-Desrosiers</i> and <i>Freyberger</i> et al. to the symposium on alexithymia. Two of these papers discuss strategies for measurement of alexithymia, using established instruments as well as a recently introduced projective test designed to measure one's ability to symbolize. The third paper discusses a treatment approach which is based upon psychodynamic principles, yet has novel and practical modifications in technique. The papers are discussed as clinical contributions to alexithymia research and are critically reviewed in regard to methodology. I contend that much research in alexithymia has not given sufficient attention to research design, thus confusing our understanding and application of the concept.
How to Get Rid of Junk Mail
Authors: EDWARD C. HEYDE
Journal: Annals of Internal Medicine (1970)

Letters and Comments1 June 1970How to Get Rid of Junk MailEDWARD C. HEYDE, M.D.EDWARD C. HEYDE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-72-6-964 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I would like to share my good fortune with my fellow members of the American College of Physicians.I recently tried to get my name off the mailing list ofGolf and Travel, one of the throw-away journals that plague us monthly. After several letters telling me it could not be done because I was on the AMA's master list or some such thing, they said, "The only way you can do it is to have your name put on the "no promotional mail" list at the AMA Central Office." This I did, and the result was... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Internal Medicine The Vancouver Clinic 111 West 39th St. Vancouver, Wash. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byJunk Mail and Mother EarthJOE D. HULL, M.D. 1 June 1970Volume 72, Issue 6Page: 964-964KeywordsPlague ePublished: 1 December 2008 Issue Published: 1 June 1970 PDF downloadLoading ...
Reversible posterior leucoencephalopathy syndrome in systemic lupus and vasculitis
Authors: A Primavera
Journal: Annals of the Rheumatic Diseases (2001)

<h3>OBJECTIVES</h3> Reversible posterior leucoencephalopathy syndrome (RPLS) may develop in patients with renal insufficiency, hypertension, and immunosuppression, and is managed by prompt antihypertensive and anticonvulsant treatment. Four patients with renal insufficiency and fluid overload associated with Wegener9s granulomatosis (one patient) and systemic lupus erythematosus (SLE) (three patients) are described, whose clinical picture and neuroimaging indicated RPLS. <h3>CASE REPORTS</h3> All patients had headache, seizures, visual abnormalities, and transient motor deficit, and were hypertensive at the onset of the symptoms. Head computed tomography (CT) scan and magnetic resonance imaging showed predominantly posterior signal abnormalities, which were more conspicuous on T<sub>2</sub> weighted spin echo images than on CT scan. All patients had some form of cytotoxic treatment shortly before the syndrome developed, and dramatically responded to blood pressure control and anticonvulsant treatment. In two patients with SLE, dialysis was required for renal insufficiency. <h3>DISCUSSION</h3> Follow up neuroimaging studies showed almost complete resolution of signal abnormalities, and suggested that RPLS was associated with cerebral oedema without concomitant infarction. The treatment of hypertension and neurotoxic condition such as uraemia appears of primary importance, while immunosuppressive treatment may cause further damage of the blood-brain barrier.