Pseudoxanthoma Elasticum
Authors: FRED F. WHITCOMB
Journal: Annals of Internal Medicine (1962)

Article1 June 1962Pseudoxanthoma ElasticumReport of Twelve Cases: Massive Gastrointestinal Hemorrhage in One PatientFRED F. WHITCOMB JR., M.D., CHARLES H. BROWN, M.D., F.A.C.P.FRED F. WHITCOMB JR., M.D.Search for more papers by this author, CHARLES H. BROWN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-56-6-834 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPseudoxanthoma elasticum is a rare, heritable, systemic disease of connective tissues characterized by degeneration of elastic tissue and mainly affecting the skin, eyes, and blood vessels. It occurs more frequently in females than in males, and the disease probably is inherited as an autosomal recessive trait (1).The clinical and histological changes in the skin in this condition were described by Balzer (2) in 1884. Darier (3), in 1896, defined the disease as a separate entity and suggested the name "pseudoxanthoma elasticum." The occurrence of angioid streaks in the retina was described by Grönblad (4) and Strandberg (5) in 1929,...References1. MCKUSICK VA: Heritable disorders of connective tissue; pseudoxanthoma elasticum. J. Chron. Dis. 3: 263, 1956. CrossrefMedlineGoogle Scholar2. BALZER F: Recherches sur les caractères anatomiques du xanthelasma. Arch. Physiol. Norm Path. (s. 3) 4: 65, 1884. Google Scholar3. DARIER J: Pseudoxanthoma elasticum. Mschr. Prakt. Derm. 23: 609, 1896. Google Scholar4. GRÖNBLAD E: Angioid streaks-pseudoxanthoma elasticum. Acta Ophthal. 7: 329, 1929. CrossrefGoogle Scholar5. STRANDBERG J: Pseudoxanthoma elasticum. Zbl. Haut Geschlechtskr. 31: 689, 1929. Google Scholar6. ROBERTSONSCHRODER MGJS: Pseudoxanthoma elasticum. A systemic disorder. Amer. J. Med. 27: 433, 1959. CrossrefMedlineGoogle Scholar7. CHAUFFARD A: Xanthélasma disséminé et symétrique, sans insuffisance hépatique. Bull. Mem. Soc. Méd. Hôp. Paris (supp. 3) 6: 412, 1889. Google Scholar8. PRICK JJ: Cited by McKusick (1) and Carlborg (10). Google Scholar9. LAW FW: Contribution to the pathology of angeoid streaks. Trans. Opthal. Soc. U. K. (part 1) 58: 191, 1938. Google Scholar10. CARLBORG U: Studies of circulatory disturbances, pulse wave velocity and pressure pulses in larger arteries in cases of pseudoxanthoma elasticum and angioid streaks: contribution to knowledge of function of elastic tissue and smooth muscles in larger arteries. Acta Med. Scand. (supp. 151): 1, 1944. Google Scholar11. REVELLCAREY STTN: Pseudoxanthoma elasticum as disseminated disease. Southern. Med. J. 41: 782, 1948. CrossrefMedlineGoogle Scholar12. WOLFFSTOKESSCHLESINGER HHJFBE: Vascular abnormalities associated with pseudoxanthoma elasticum. Arch. Dis. Child. 27: 82, 1952. CrossrefMedlineGoogle Scholar13. KAPLANHARTMAN ISW: Elastica disease, case of Grönblad-Strandberg syndrome with gastrointestinal hemorrhage. Arch. Intern. Med. 94: 489, 1954. CrossrefGoogle Scholar14. REINERTSONFARBER RPEM: Pseudoxanthoma elasticum with gastrointestinal bleeding. Calif. Med. 83: 94, 1955. MedlineGoogle Scholar15. MANLEYSKYRING KAAP: Some heritable causes of gastrointestinal disease; special reference to hemorrhage. Arch. Intern. Med. 107: 182, 1961. CrossrefMedlineGoogle Scholar16. WOOCHANDLER JCFW: Pseudoxanthoma elasticum with gastric hemorrhage; report of a case. Ann. Intern. Med. 49: 215, 1958. LinkGoogle Scholar17. FISHERRODNANLANSING ERGPAI: Identification of the anatomic defect in pseudoxanthoma elasticum. Amer. J. Path. 34: 977, 1958. MedlineGoogle Scholar18. LORIAKENNEDYFREEMANHENINGTON PRCBJAVM: Pseudoxanthoma elasticum (Grönblad-Strandberg syndrome); a clinical, light-, and electron-microscopic study. Arch. Derm. 76: 609, 1957. CrossrefGoogle Scholar19. BROWNBISSONNETTEALBEE CHRPRD: Diverticula of the stomach; a report of thirty cases and a review of the literature. Gastroenterology 12: 10, 1949. CrossrefMedlineGoogle Scholar20. BROWNHOERR CHSO: The treatment of duodenal ulcer. Postgrad. Med. 12: 308, 1952. CrossrefMedlineGoogle Scholar21. SANDBACKA-HOLMSTRÖM I: Das Grönblad-Strandberg'sche Syndrom. Pseudoxanthoma elasticum-angioid streaks—Gefässveränderungen. Acta Dermatovener. 20: 684, 1939. Google Scholar22. WOODCOCK CW: Pseudoxanthoma elasticum angioid streaks of retina, and osteitis deformans. Society Transactions, Cleveland Dermatological Society. Arch. Derm. Syph. 65: 623, 1952. Google Scholar23. SCHEIEHOGAN HGTF: Angioid streaks and generalized arterial disease. Arch. Opthal. 57: 855, 1957. CrossrefMedlineGoogle Scholar24. MCCAUGHEYALEXANDERMORRISH RSLCJA: The Grönblad-Strandberg syndrome; a report of three cases presenting with massive gastrointestinal hemorrhage during pregnancy. Gastroenterology 31: 156, 1956. CrossrefMedlineGoogle Scholar25. CARLBORGEJRUPGRÖNBLADLUND WBEF: Vascular studies in pseudoxanthoma elasticum and angioid streaks; with a series of color photographs of the eyeground lesions. Acta Med. Scand. (supp. 350) 166: 1, 1959. Google Scholar26. SHAFFERCOPELANBEERMAN BHWH: Pseudoxanthoma elasticum; a cutaneous manifestation of a systemic disease; report of a case of Paget's disease and a case of a calcinosis with arteriosclerosis and manifestations of this syndrome. Arch. Dermat. Syph. 76: 622, 1957. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Cleveland, OhioFrom the Department of Gastroenterology, The Cleveland Clinic Foundation, Cleveland, Ohio.Requests for reprints should be addressed to Charles H. Brown, M.D., Department of Gastroenterology, Cleveland Clinic, 2020 East 93d Street, Cleveland 6, Ohio. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byVascular Manifestations of Pseudoxanthoma ElasticumHistorical evidence for the genetic heterogeneity of pseudoxanthoma elasticumPathogenetische Fragen zum Darier-Grönblad-Strandberg SyndromGrönblad-Strandberg-SyndromRöntgendiagnostik der Muskeln, Sehnen und Bänder Pathologische Verdichtungen und Aufhellungen im WeichteilmantelMedical genetics 1962 1 June 1962Volume 56, Issue 6Page: 834-842KeywordsAnginaAutosomal recessive diseasesBlood vesselsHypertensionRetinaSystemic diseasesThoraxUlcersVision Issue Published: 1 June 1962 PDF downloadLoading ...