Twenty Years of the Lupus Erythematosus Cell
Authors: FREDERIC C. MCDUFFIE
Journal: Annals of Internal Medicine (1969)

Editorials1 February 1969Twenty Years of the Lupus Erythematosus CellFREDERIC C. MCDUFFIE, M.D., F.A.C.P.FREDERIC C. MCDUFFIE, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-70-2-413 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn November 1968 a symposium was held in Rochester, Minn., to commemorate the twentieth anniversary of the discovery of the lupus erythematosus (LE) cell by Hargraves, Richmond, and Morton (1). The best testimony to the importance of their finding is that almost all the extensive clinical and laboratory investigation on lupus erythematosus since that date has been based on this single observation and the subsequent identification of the LE factor as an immunoglobulin (2). After 20 years, the cause of lupus erythematosus still remains a mystery, but recent immunopathologic studies of the glomerular lesion of this disease offer an attractive...References1. HARGRAVES MM, RICHMOND H, and MORTON R: Presentation of two bone marrow elements: the "tart" cell and the "L.E." cell. Proc. Mayo Clin. 23: 25, 1948. MedlineGoogle Scholar2. HASERICK JR, LEWIS LA, and BORTZ DW: Blood factor in acute disseminated lupus erythematosus. I. Determination of gamma globulin as specific plasma fraction. Amer. J. Med. Sci. 219: 660, 1950. CrossrefMedlineGoogle Scholar3. GODMAN G and DEITCH AD: A cytochemical study of the L.E. bodies of systemic lupus erythematosus. I. Nucleic acids. J. Exp. Med. 106: 575, 1957. CrossrefMedlineGoogle Scholar4. AISENBERG AC: Studies on the mechanism of the lupus erythematosus (L.E.) phenomenon. J. Clin. Invest. 38: 325, 1959. CrossrefMedlineGoogle Scholar5. 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PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySystemic Lupus ErythematosusLEUCOCYTE STIMULATION BY AUTOHOMOGENATE IN SYSTEMIC LUPUS ERYTHEMATOSUS MEASURED WITH FLOW MICROCALORIMETRYDiagnosis and Treatment of Lupus NephritisThe Anti-Nuclear Factor Immunofluorescent TestSerological factors in systemic lupus erythematosus and their pathogenetic significance 1 February 1969Volume 70, Issue 2Page: 413-417KeywordsClinical laboratoriesLesionsLupus erythematosusNeutrophilsResearch laboratories ePublished: 1 December 2008 Issue Published: 1 February 1969 PDF downloadLoading ...