tbuckley/cabot-search huggingface dataset:
Silkworm Gut, Not Silk, for the Sustaining Sutures in Fixation of the Kidney.
Authors: Augustin H. Goelet
Journal: JAMA (1903)

New York, March 7, 1903. <h3>To the Editor:</h3> —InThe Journalof March 7, page 665, in the report of the proceedings of the New York County Medical Association it is incorrectly stated that I prefer silk for suturing the kidney. I employ temporary sutures of silkworm gut which are brought out through all the structures of the back and tied over a fold of gauze.
Soziometrische Position und Gesprächsyerhalten in stationaren Manner-und Frauengruppen
Authors: A. Ploeger, P. Schlunk
Journal: Psychotherapy and Psychosomatics (1968)

Research Articles| February 12 2010 Soziometrische Position und Gesprächsverhalten in stationaren Manner-und Frauengruppen Subject Area: Psychiatry and Psychology A. Ploeger; A. Ploeger Universitätsnervenklinik Tübingen (Direktor: Prof. Dr. W. Schulte) Search for other works by this author on: This Site PubMed Google Scholar P. Schlunk P. Schlunk Universitätsnervenklinik Tübingen (Direktor: Prof. Dr. W. Schulte) Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1968) 16 (1-3): 159–166. https://doi.org/10.1159/000285930 Article history Published Online: February 12 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation A. Ploeger, P. Schlunk; Soziometrische Position und Gesprächsverhalten in stationaren Manner-und Frauengruppen. Psychother Psychosom 31 December 1968; 16 (1-3): 159–166. https://doi.org/10.1159/000285930 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal 1968Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Reduction of Toxicity of 5-Fluorouracil Cancer Chemotherapy.
Authors: Henry M. Lemon
Journal: Annals of Internal Medicine (1964)

s1 February 1964Reduction of Toxicity of 5-Fluorouracil Cancer Chemotherapy.Henry M. Lemon, M.D., F.A.C.P., P. J. Mozden, M.D.Henry M. Lemon, M.D., F.A.C.P.Search for more papers by this author, P. J. Mozden, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-2-333_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptToxicity that has handicapped the utilization of 5-fluorouracil for cancer chemotherapy has been greatly reduced by intravenous infusion of drug in 5% dextrose over an 8-hour period, permitting increased dosage and use with radiation therapy. This report evaluates over 100 slowly infused patients in whom moderate to severe toxicity occurred in only 6% with doses up to 25 g in as many days. Objective remissions attributed to drug alone were noted in 10%, with another 20% responding to combination therapy using X ray or steroids. Adenocarcinoma of the rectum and colon, breast, and ovary were most often responsive, with relief... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1964Volume 60, Issue 2_Part_1Page: 333-333KeywordsAdverse reactionsCancer chemotherapyColonDrug therapyGlucoseOvariesRadiation therapyRectumSteroidsToxicity Issue Published: 1 February 1964 PDF DownloadLoading ...
Survival Is Similar After Standard Treatment and Chest Compression Only in Out-of-Hospital Bystander Cardiopulmonary Resuscitation
Authors: Katarina Bohm, Mårten Rosenqvist, Johan Herlitz, Jacob Hollenberg, Leif Svensson
Journal: Circulation (2007)

Background— We sought to compare the 1-month survival rates among patients after out-of-hospital cardiac arrest who had been given bystander cardiopulmonary resuscitation (CPR) in relation to whether they had received standard CPR with chest compression plus mouth-to-mouth ventilation or chest compression only. Methods and Results— All patients with out-of-hospital cardiac arrest who received bystander CPR and who were reported to the Swedish Cardiac Arrest Register between 1990 and 2005 were included. Crew-witnessed cases were excluded. Among 11 275 patients, 73% (n=8209) received standard CPR, and 10% (n=1145) received chest compression only. There was no significant difference in 1-month survival between patients who received standard CPR (1-month survival=7.2%) and those who received chest compression only (1-month survival=6.7%). Conclusions— Among patients with out-of-hospital cardiac arrest who received bystander CPR, there was no significant difference in 1-month survival between a standard CPR program with chest compression plus mouth-to-mouth ventilation and a simplified version of CPR with chest compression only.
CONSTITUTIONAL FACTORS AS AN AID TO THE EARLY EVALUATION OF BEHAVIOR DISORDERS
Authors: F. I. WERTHEIMER
Journal: JAMA (1927)

It is often thought that interest in the constitutional aspects of pathology, that is to say in those factors which are definitely more hereditary than environmental, goes hand in hand with a neglect of therapeutic and prophylactic endeavor. This belief, which amounts almost to a prejudice against constitutional studies, is not borne out by the historical evidence of the development of medicine. In the beginning of the nineteenth century, for example, when constitutional studies were still in the center of medical interest, the attitude toward therapy was an optimistic one; at the end of the nineteenth century, with its startling discoveries of exogenic factors of disease, there developed gradually a more pessimistic and nihilistic attitude toward therapy. In the field of mental diseases one can point to Morel, the first psychiatrist to recognize the importance of heredity as a guiding factor in the multiformity of psychopathologic reactions, as also one
Treatment of Recurrent Herpes
Authors: S. P. Hall-Smith, M. J. Gilkes
Journal: BMJ (1964)

SIR,-After reading recent favourable re- ports concerning buccal oxytocin"3 many obstetricians will have chosen this simpler way of inducing labour.The more conserva- tive among us have awaited news of its dangers.Your leading article (19 September, p. 705) sounded a warning note which might have been louder.The report of a case of ruptured uterus, accompanied by photographs which call to mind the bad old days of intra- muscular Pitocin (oxytocin) (12 September, p. 689) and the further report (3 October, p. 876) of two alarming cases of fierce uterine overactivity are surely good reasons for calling a halt.Pitocin (oxytocin) and its synthetic equiva-
Letter by Guazzi Regarding Article “Sleep and Exertional Periodic Breathing in Chronic Heart Failure: Prognostic Importance and Interdependence”
Authors: Marco Guazzi
Journal: Circulation (2006)

I read with interest the article by Corrà and associates 1 that appeared in a recent Circulation issue.In 133 chronic heart failure patients, the authors elegantly demonstrated that those (nϭ22) who exhibit both central sleep apnea (CSA; apnea/ hypopnea index Ն30) and exercise oscillatory ventilation (EOV) have a very unfavorable prognosis.The negative survival expectation is, however, primarily driven by CSA, a recognized prognostic marker, rather than by EOV, a disorder found to be prognostic irrespective of CSA coexistence. 2Accordingly, patients with isolated EOV had clinical data and survival rates similar to those without oscillatory kinetics.This observation suggests that EOV may not hold clinical importance and weakens the argument for interdependent pathways in the genesis of EOV and CSA.As an overall comment, any reasoning on this category of patients is likely flawed by the small number of subjects investigated (nϭ6).This is the first study in which EOV was tested against exercise V ˙E/V ˙CO 2 slope, a powerful prognosticator in chronic heart failure patients with intermediate performance. 3Statistical comparison is not reported, and at the multivariate Cox analysis, CSA, peak V ˙O2 , and ␤-blocker therapy emerged as prognostic, whereas V ˙E/V ˙CO 2 slope, in contrast with established evidence, did not.The information may be misleading in some instances and can be explained by technical difficulties related to the calculation of V ˙E/V ˙CO 2 slope in the setting of oscillatory gas kinetics, including the definition of its linear relationship from the beginning of exercise to the isocapnic compensatory point.The concern is strengthened by the discrepancies among the few studies available.In 25 similar patients, Leite et al 2 reported an average V ˙E/V ˙CO 2 slope of 48.7, which is similar to the 46.6 reported in another study involving 10 patients. 4Both studies appear far from the V ˙E/V ˙CO 2 slopes of 30 (EOV alone) and 40 (CSA and EOV) reported by Corrà et al.Thus, in the presence of EOV, a correct V ˙E/V ˙CO 2 slope measure and interpretation should require further mathematical elaboration.These are questions that Corrà et al may help to interpret to further expand our knowledge on the complex and fascinating relationships among exercise ventilation inefficiency, sleep disorders, and life expectancy across different chronic heart failure populations.
C-reactive Protein, Obstructive Sleep Apnea, and Cognitive Dysfunction in School-aged Children
Authors: David Gozal, Valerie McLaughlin Crabtree, Oscar Sans Capdevila, Lisa A. Witcher, Leila Kheirandish-Gozal
Journal: American Journal of Respiratory and Critical Care Medicine (2007)

Obstructive sleep apnea (OSA) in children is associated with substantial neurobehavioral and cognitive dysfunction. However, not all children with OSA exhibit altered cognitive performance.To assess the magnitude of the systemic inflammatory response, as measured by high-sensitivity C-reactive protein (hsCRP) serum levels which may identify children with OSA at higher susceptibility for cognitive morbidity.Habitually snoring children and nonsnoring children (total, 278; age range, 5-7 yr) were recruited from the community, and underwent overnight polysomnography and neurocognitive testing and a blood draw the next morning. Snoring children were divided into OSA and no-OSA groups, and children with OSA were further subdivided into those with two or more abnormal cognitive subtests and into those with normal cognitive scores. Serum levels of hsCRP were also measured.Among snoring children without OSA, mean hsCRP was 0.19+/-0.07 mg/dl compared with 0.36+/-0.11 mg/dl in those with OSA (p<0.01). Furthermore, hsCRP was 0.48+/-0.12 mg/dl in children with OSA and cognitive deficits, compared with 0.21+/-0.08 mg/dl in children with OSA and normal cognitive scores (p<0.002).hsCRP levels are higher in children with OSA, and particularly in those who develop neurocognitive deficits, suggesting that the magnitude of the inflammatory responses elicited by OSA is a major determinant of increased risk for neurocognitive dysfunction.
A young man with a solitary hepatic mass
Authors: Jane M. Geders, Salima Haque, Raymond J. Tesi, Michael A. Gerber, Anna S. F. Lok
Journal: Hepatology (1995)

A 36-year-old black male was referred in January 1994 for evaluation of a symptomatic hepatic mass.For 2 years before presentation he had been treated intermittently with cimetidine for chronic abdominal pain attributed to ulcer disease.An upper gastrointestinal series performed in December 1993 revealed marked scarring and irregularity of the duodenal bulb consistent with the diagnosis of chronic duodenal ulcer.Symptoms of early satiety were observed at this time.The patient reported no weight loss, fever, anorexia, or fatigue.An abdominal computed tomography (CT) scan confirmed a 13-cm, low attenuation, irregular mass in this same region.He had no history of hepatitis or jaundice.His childhood medical history was negative.He underwent a unilateral orchiectomy at age 25 years and a vasectomy in 1992.He had no history of blood transfusion or intravenous drug use.He admitted to occasional alcohol use.He was employed as a Merchant Marine and had traveled to Africa, the Far East, and South America.His sister had a "liver problem" for which she received 2 years of unknown medical therapy.Physical examination revealed a liver palpable in the epigastrium with a smooth edge and a span in the right mid-clavicular line of 14 cm.He had no ascites, peripheral edema, spider nevi, lymphadenopathy, jaundice, or splenomegaly.Blood tests showed a hemoglobin value of 14.4 g/dL (normal, 13 to 18 g/dL), a white cell count of 5.6 x 103/pL (normal, 4.5 to 11 X 103/pL), platelet count of 227 X 103/pL (normal, 160 to 420x 103/pL), an albumin level of 4.6 g/dL (normal, 3.7 to 5.0 g/dL), a total globulin level of 3.1 gm/dL (normal, 0.6 to 1.8 g/dL), an aspartate aminotransferase level of 17 U/L (normal, <39), an alanine aminotransferase
Thrombopoietin — Clinically Realized?
Authors: Jack Levin
Journal: New England Journal of Medicine (1997)

For approximately 30 years, hematologists have sought the humoral regulator of platelet production, thrombopoietin.1 Although a factor with the appropriate physiologic effects was partially purified, the goal continued to evade researchers until 1994, when three laboratories simultaneously reported that c-Mpl ligand had the characteristics of thrombopoietin.2 Synonyms for thrombopoietin in the literature are c-Mpl ligand, mpl ligand, megapoietin, and megakaryocyte growth and development factor (a truncated version of thrombopoietin).What explains the fact that thrombopoietin was ultimately purified and characterized by five laboratories almost simultaneously? In 1992, Wendling and colleagues described the c-mpl gene, the cellular homologue of v- . . .
Former FDA commissioner pleads guilty to two charges
Authors: Janice Hopkins Tanne
Journal: BMJ (2006)

Lester Crawford, the former commissioner of the US Food and Drug Administration, pleaded guilty in a district court in Washington, DC, last week to two charges: conflict of interest and failing to disclose financial holdings in companies that the FDA regulated. Each charge carries a maximum penalty of a year in prison and a fine. Dr Crawford will be sentenced on 22 January 2007.

Dr …
Condensing Enzyme Levels in the Serum After Experimental Myocardial Infarction
Authors: GEORGE W. KOSICKI, HENRY H. SWAIN, PAUL A. SRERE
Journal: Circulation Research (1960)

Increased levels of condensing enzyme are shown to occur in the sera of dogs after experimental myocardial infarction. The animals with the elevated levels also showed characteristic changes of the electrical activity of the heart and associated increases in the glutamate-oxal acetate transaminase activity of serum. Condensing enzyme has been detected in the sera of patients who suffered myocardial infarctions.
804-2 Low Molecular Weight Heparin, Regular Heparin or Aspirin to Treat Silent Ischemia in Unstable Angina
Authors: Enrique Gurfinkel, Ricardo Mejall, Eustaquio Manos, Miguel Cerdá, Ernesto Duranto, Claudio Garcia, Ana Daroca, Branco Mautner
Journal: Journal of the American College of Cardiology (1995)
Occurrence of antiperinuclear, antikeratin, and anti-RA 33 antibodies in juvenile chronic arthritis.
Authors: C Gabay, A M Prieur, O Meyer
Journal: Annals of the Rheumatic Diseases (1993)

OBJECTIVES--Antiperinuclear factor (APF), antikeratin antibodies (AKA), and anti-RA 33 antibodies are currently considered to be good markers for the diagnosis of adult rheumatoid arthritis with or without rheumatoid factor (RF). The prevalence of these markers was retrospectively reviewed in children with juvenile chronic arthritis (JCA) to determine whether they were associated with specific features. METHODS--One hundred and twenty-four patients with JCA participated in this study. Controls included 28 patients with juvenile systemic lupus erythematosus and 21 healthy children. Antiperinuclear factor and AKA were determined by indirect immunofluorescence on buccal mucosal cells and oesophagus sections respectively. Anti-RA 33 antibodies were detected using a Western blot technique on HeLa cell nuclear extract. RESULTS--Antiperinuclear factor was virtually absent in all the tested subgroups and anti-RA 33 antibodies were detected only in a subset of patients with RF positive polyarticular onset. Antikeratin antibodies were found in 27% of all children with JCA and in 42% of those with RF negative polyarticular onset. These results were statistically significant compared with healthy controls, but the presence of AKA was not specific to any patient subgroup. Moreover, in contrast with previous studies in adult RA, no relation was found between the presence of AKA and disease severity or activity. CONCLUSION--These data suggest that APF, AKA, and anti-RA 33 antibodies are not useful for the diagnosis or classification of JCA.
Abstract 1949: P38MAPK plays a tumor suppressive role through differentiation of ALDHhigh/CD44high tumor iniating cells in primary human lung adenocarcinoma
Authors: Jing Liu, Lai-han Leung, Zhi-jie Xiao, Vicky P. Tin, Maria Pik Wong
Journal: Cancer Research (2014)

Abstract The p38 MAPK cascade regulates body responses to a wide range of stress stimuli in a context-dependent and tissue-specific manner. The isoform p38alpha (p38) mediates both tumor suppressive and tumor-supportive functions in different cancer models. However, its role in lung cancer is not clear. Since EGFR is frequently mutated in lung adenocarcinomas in non-smoking women and p38 is a downstream target of EGFR signaling, it is possible that p38 plays a tumor-supportive role. Using immunohistochemistry to analyze nuclear activated p38 expression in 90 lung adenocarcinomas, we observed p38 expression was significantly associated with well differentiated compared to poorly-differentiated carcinomas (p&amp;lt;0.001) and better patient outcome (p=0.019, disease-free survival; p=0.03, overall survival). In vitro p38 suppression in lung cancer cell lines did not lead to enhanced cell death. On the other hand, p38 suppression alone or in combination with EGFR inhibition led to increased CD44high/ALDHhigh lung tumor initiating cells (TIC); isolated lung TIC also showed higher p38 expression. Together, the data implicate p38 plays a tumor suppressive role in lung cancer by driving tumor cell differentiation. Disrupting pathways that inhibit p38 expression or enhancement of p38 expression might be useful for lung cancer treatment. Citation Format: Jing Liu, Lai-han Leung, Zhi-jie Xiao, Vicky PC Tin, Maria Pik Wong. P38MAPK plays a tumor suppressive role through differentiation of ALDHhigh/CD44high tumor iniating cells in primary human lung adenocarcinoma. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1949. doi:10.1158/1538-7445.AM2014-1949
PD-L1 blockade effectively restores strong graft-versus-leukemia effects without graft-versus-host disease after delayed adoptive transfer of T-cell receptor gene-engineered allogeneic CD8+ T cells
Authors: Wolfgang Koestner, Martin Hapke, Jessica Herbst, Christoph Klein, Karl Welte, Joerg Fruehauf, Andrew Flatley, Dario A. Vignali, Matthias Hardtke-Wolenski, Elmar Jaeckel, Bruce R. Blazar, Martin G. Sauer
Journal: Blood (2010)
Trial results: the next battle
Authors: Kamran Abbasi
Journal: BMJ (2005)

medical care, complications, and degree of functioning and pain) differed significantly between the groups, but patients' satisfaction was greater among patients treated at home. Clustering in trials needs more recognitionClustering in clinical trials randomising individuals needs to receive more attention in statistical analysis, discussion of the results, and drawing conclusions, argue Lee and Thompson (p 142).Reviewing all non-cluster randomised trials published in the BMJ during 2002, they found that 19 out of 42 trials showed clustering that was likely to affect their results, but only one attempted to take the issue into account.The authors show by example how clustering can affect a trial's results and conclusions.
Quantifying the Federal Minimal Risk Standard
Authors: David Wendler, Leah Belsky, Kimberly M. Thompson, Ezekiel J. Emanuel
Journal: JAMA (2005)

United States federal regulations allow institutional review boards (IRBs) to approve pediatric research that does not offer participants a "prospect of direct" benefit only when the risks are minimal or a "minor" increase over minimal. The federal regulations define minimal risks based on the risks "ordinarily encountered in daily life or during routine physical or psychological examinations or tests." In the absence of empirical data, IRB members may assume they are familiar with the risks of daily life and with the risks of routine examinations and tests and rely on their own intuitive judgment to make these assessments. Yet intuitive judgment of risk is subject to systematic errors, highlighting the need for empirical data to guide IRB review and approval of pediatric research. Current data reveal that car trips pose the highest risk of mortality ordinarily encountered by healthy children. On average, these risks are approximately 0.06 per million for children aged 14 years and younger, and approximately 0.4 per million for children aged 15 through 19 years. Riskier, but still ordinary, car trips pose an approximately 0.6 per million chance of death for children aged 14 years and younger and an approximately 4 per million chance of death for children aged 15 through 19 years. Participation in sports represents the upper end of the range of morbidity risks for healthy children. For every million instances of playing basketball, approximately 1900 individuals will sustain injuries, including 180 broken bones and 58 permanent disabilities. These findings suggest IRBs are implementing the federal minimal risk standard too cautiously in many cases. These data also raise the question of whether the federal minimal risk standard may sometimes fail to provide sufficient protection for children, prompting the need to consider alternative standards.