tbuckley/cabot-search huggingface dataset:
Measuring cardiolipin antibodies
Authors: A M. Ward, P A E White
Journal: BMJ (1995)

able, within its limited resources, to respond to the enormous changes in its constituents and their needs over the past five years."Our mission is, indeed, to use our influence to improve people's health while adapting our work to the major changes that are occurring in our region.We do not, however, believe that we can alter overnight health behaviour that has been shaped over generations.Changes in this can be achieved only through a long term vision, implemented through consistent action.This is the
The sarcoplasmic reticulum and arrhythmogenic calcium release
Authors: L. A. Venetucci, A. W. Trafford, S. C. O'Neill, D. A. Eisner
Journal: Cardiovascular Research (2007)

There is much evidence showing that some lethal ventricular arrhythmias arise from waves of Ca(2+) release from the sarcoplasmic reticulum (SR) that propagate along cardiac cells. The purpose of this review is to discuss the mechanism of production of these waves and how they depend on the properties of the SR Ca(2+) release channel or ryanodine receptor (RyR). The best-known method of producing Ca(2+) waves is by increasing the Ca(2+) content of the cell by either increasing Ca(2+) influx or decreasing efflux. Once SR Ca(2+) content reaches a threshold level a Ca(2+) wave is produced. Altering the properties of the RyR affects the threshold level of Ca(2+) required to produce a wave. Patients with a mutation in the RyR suffer from catecholaminergic polymorphic ventricular tachycardia, and this may be due to a decrease in the SR Ca(2+) threshold for wave production. Heart failure has also been suggested to result in Ca(2+) waves due to a leak of Ca(2+) through the RyR. We review the finding that these changes in RyR function will only result in Ca(2+) waves in the steady state if some other mechanism maintains the SR Ca(2+) content. The review concludes with a description of potential mechanisms for treating arrhythmias produced by Ca(2+) waves.
GPs may be balloted over NHS reforms
Authors: L. Beecham
Journal: BMJ (1998)

GPs in England may be balloted on some of the sticking points that remain unresolved between the profession and the health department over the introduction of primary care groups (PCGs). PCGs were proposed in the government's white paper for England, The New NHS. 

The General Medical Services Committee decided last week to continue talks with departmental officials, including a meeting with the health minister, Alan Milburn, scheduled for 11 June. GP negotiators will report back to a special GMSC meeting on 18 June. The committee gave its leaders the freedom to ballot GPs at any time. The …
Case of Acute Rheumatism Treated with Salicylate of Soda: Rapid Recovery
Authors: T. Jones
Journal: BMJ (1876)

shuts it off from its perilous neighbours: the ossicula may be dis- charged, and even the cochlea and labyrinth, without any bad symp- toms supervening.I trust I have shown by these remarks the importance of investigating otorrhoea in connection with assurance; and I would suggest that no life should be certified as first-class, or even second-class, in whom examination indicates a suspicion of caries, or the existence or recent occurrence of anything like an inflammatory process.I shall be glad if the subject elicit opinions from members of the profession engaged in life-examinations.
Tissue level perfusion after primary or rescue coronary angioplasty in acute myocardial infarction: A myocardial contrast echocardiography study
Authors: Luciano Agati, Carlo Iacoboni, Francesca De Maio, Stefania Funaro, Mariapina Madonna, Flavia Celani, Rachele Adorisio, Giulia Benedetti, Francesco Fedele
Journal: Journal of the American College of Cardiology (2003)
Photo-cured hyaluronic acid-based hydrogels containing simvastatin as a bone tissue regeneration scaffold
Authors: Min Soo Bae, Dae Hyeok Yang, Jung Bok Lee, Dong Nyoung Heo, Yong-Dae Kwon, In Chan Youn, Kuiwon Choi, Jong Hyun Hong, Gye Tae Kim, Yong Suk Choi, Eui Hwan Hwang, Il Keun Kwon
Journal: Biomaterials (2011)
SIMPLE APPARATUS FOR FRACTIONAL FILTRATION BY GRAVITY OR SUCTION
Authors: Leland W. Parr
Journal: JAMA (1923)

It is often desirable to obtain fractions in the filtration of a bacterial culture or other material. The apparatus described and illustrated here has been found very satisfactory for this sort of work, and has the advantage that it involves no costly material or unusual technic. The Mandler or Berkefeld filter is assembled as usual, after thorough cleaning. Then a two-hole No. 4 rubber stopper (<i>E</i>) is taken, and the stem (<i>D</i>) of the assembled filter is pushed about half way through one of the holes from the top side. Into this hole, but from the bottom, a short piece of straight glass tubing (<i>A</i>) is inserted. A second piece of glass tubing (<i>B</i>), 3 or 4 inches long and bent at right angles, is inserted through the second hole of the stopper from the top side. The stopper, so equipped with filter and tubes, is then inserted into the
A Phase II Study of the Combination of Endocrine Treatment and Bortezomib in Patients with Endocrine Resistant Metastatic Breast Cancer.
Authors: X. Trinh, S. Van Laere, I. Deleu, H. van de Velde, I. Van der Auwera, R. Limame, A. Wojtasik, H. Maes, P. De Mesmaeker, P. van Dam, A. Prové, J. Vandebroek, M. Rasschaert, P. Vermeulen, L. Dirix
Journal: Cancer Research (2009)

Abstract Background: The introduction of anti-hormonal treatment has been a major revolution in breast cancer management. The majority of patients with metastatic hormone receptor-positive breast cancer eventually suffer from progression of their disease despite different types of anti-hormonal treatment. Preclinical studies have indicated bidirectional inhibitory interactions between ER and NF-kappaB, governing in part endocrine-resistance and enhanced growth. The hypothesis that inhibition of NF-kappaB activation by a proteasome inhibitor might reverse the sensitivity to endocrine therapy was the rationale to initiate a phase II trial.Aim, Material and Methods: The aim is to investigate whether the addition of open label bortezomib to either a SERM or an AI will result in documented activity in patients with progressive and measurable disease on the identical endocrine agent. This endpoint is evaluated according to RECIST criteria every 8 weeks. The patients are stratified into 2 treatment groups, according to their current endocrine treatment either tamoxifen or an AI. Bortezomib is administered on days 1, 8, 15, 21 of a 6 week regimen at a dose of 1.6 mg/sqm on each treatment day. Consecutive tumour biopsies (if accessible) and blood samples are collected for translational purposes. Clinical benefit was predefined by the patients obtaining at least either stable disease, or a partial or a complete response according to RECIST criteria, lasting for at least four weeks. A two-stage statistical approach showed that this should at least occur in 1 patient in the first cohort of 14 patients, prior to further accrual.Results: At present N=9 patients have been enrolled. Eight patients received AI+bortezomib, while one received TAM+bortezomib. N=5/9 patients had progressive disease, N=4/9 patients had stable disease of which two patients (N=2/9) had stable disease continuing for more than 4 weeks. There were no objective antitumour responses observed. N=4/9 had grade III diarrhoea. Median time to treatment failure was 69 days [35-140], either due to toxicity (N=3/9) or (eventual) progression (N=6/9).Conclusions: Preliminary results shows that the clinical benefit rate is 22% (N=2/9). Although preliminary, these results warrant further accrual and suggest that the biological hypothesis seems clinically valid. Further recruitment is ongoing. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 4099.
Effect of Sedation With Dexmedetomidine vs Lorazepam on Acute Brain Dysfunction in Mechanically Ventilated Patients
Authors: Pratik P. Pandharipande, Brenda T. Pun, Daniel L. Herr, Mervyn Maze, Timothy D. Girard, Russell R. Miller, Ayumi K. Shintani, Jennifer L. Thompson, James C. Jackson, Stephen A. Deppen, Renee A. Stiles, Robert S. Dittus, Gordon R. Bernard, E. Wesley Ely
Journal: JAMA (2007)

4][5][6] Because delirium is an independent risk factor for prolonged length of stay, greater neuropsychological dysfunction, and increased mortality, 7-10 efforts must be made to reduce this manifestation of organ dysfunction within the context of providing adequate sedation for patients.Lorazepam is currently recommended by the Society of Critical Care Medicine (SCCM) in its clinical prac-tice guidelines 1 for the sustained sedation of mechanically ventilated ICU patients.Although recent trials have shown that protocols with patient-targeted se-
Vagal afferent inhibition of spinothalamic cell responses to sympathetic afferents and bradykinin in the monkey.
Authors: W S Ammons, R W Blair, R D Foreman
Journal: Circulation Research (1983)

Effects of stimulating the left thoracic vagus nerve on the responses of spinothalamic neurons to electrical stimulation of cardiopulmonary sympathetic afferent fibers and to intracardiac injections of bradykinin were determined. Experiments were performed on 39 monkeys (Macaca fascicularis) tranquilized with ketamine and anesthetized with alpha-chloralose. The 30 spinothalamic cells studied had the following characteristics. They were excited by manipulation of their somatic receptive fields, were excited by electrical stimulation of cardiopulmonary sympathetic afferent fibers, and exhibited viscerosomatic convergence. Responses of 15 of 19 cells to sympathetic afferent test stimuli were inhibited by conditioning stimuli applied to left thoracic vagus nerve. A conditioning-test interval of 40-50 msec resulted in maximal inhibition of responses to both A delta and C fiber sympathetic afferents. A long time course of inhibition was present to at least a conditioning-test interval of 200 msec. Left thoracic vagus nerve stimulation inhibited 14 of 14 cells responding to intracardiac injection of bradykinin. Entrainment of activity of five cells to the cardiac cycle occurred in response to bradykinin. In each case, left thoracic vagus nerve stimulation, in addition to reducing frequency of cell discharge, disrupted the cardiac related pattern of cell activity. Bilateral cervical vagotomy abolished all inhibitory effects of left thoracic vagus nerve stimulation. These results demonstrate that vagal afferents may participate in processing of information related to cardiac pain.
Fludarabine, cyclophosphamide, and rituximab chemoimmunotherapy is highly effective treatment for relapsed patients with CLL
Authors: Xavier C. Badoux, Michael J. Keating, Xuemei Wang, Susan M. O'Brien, Alessandra Ferrajoli, Stefan Faderl, Jan Burger, Charles Koller, Susan Lerner, Hagop Kantarjian, William G. Wierda
Journal: Blood (2011)
PSYCHIATRIC EVALUATION OF "NORMAL CONTROL" VOLUNTEERS
Authors: WILLIAM POLLIN, SEYMOUR PERLIN
Journal: American Journal of Psychiatry (1958)

1. Psychiatric evaluation of a group of 29 volunteer research subjects demonstrated the presence of significant psychopathology in 15. In 11 of the 29 subjects psychiatric diagnoses were made. 2. There was an inverse relationship in this volunteer group between the presence of psychopathology ( and psychiatric diagnosis) and the extent to which environmental influences contributed to serving as a volunteer. 3. The incidence of psychopathology in a subgroup whose volunteer status was largely due to their draft status was 28%; in a second subgroup whose volunteer status conformed with socio-cultural tradition, 59%; in a third subgroup where neither of these factors was operative, 100%. The incidence of psychiatric diagnosis increased in the same direction. 4. The volunteer group showed considerable differences in the motivations involved in volunteering, in the ability of its members to accommodate to stress, in defense mechanisms employed, and in the tendency to somaticize anxiety. 5. These differences, and the relationship between volunteering and psychopathology, raise a number of questions pertinent to the selection of volunteer groups, and the interpretation of results obtained from them. These questions are discussed.
Evidence that IGF-binding protein-5 functions as a growth factor
Authors: Naohisa Miyakoshi, Charmaine Richman, Yuji Kasukawa, Thomas A. Linkhart, David J. Baylink, Subburaman Mohan
Journal: Journal of Clinical Investigation (2001)

Recent studies support the concept that IGF-binding protein-5 (IGFBP-5) stimulates bone formation, at least in part, via IGF-independent mechanisms. To evaluate this hypothesis further, we evaluated in vitro and in vivo effects of IGFBP-5 on bone formation parameters using the IGF-I knockout (KO) mouse. Treatment of serum-free cultures of osteoblast clones derived from IGF-I KO mice with recombinant human IGFBP-5 increased both proliferation and alkaline phosphatase (ALP) activity in a dose-dependent manner, an effect comparable to that seen with IGF-I. IGF-II levels from media conditioned by osteoblasts derived from IGF-I KO mouse were below those detectable by RIA. To eliminate possible actions of IGF-II, if any was produced by osteoblasts derived from IGF-I knockout mice, the IGFBP-5 effect was studied in the presence of exogenously added IGFBP-4, a potent inhibitor of IGF-II actions in bone cells. Addition of IGFBP-4 blocked IGF-I– but not IGFBP-5–induced cell proliferation in osteoblasts derived from IGF-I knockout mice. Consistent with in vitro results, a single local injection of IGFBP-5 to the outer periosteum of the parietal bone of IGF-I KO mice increased ALP activity and osteocalcin levels of calvarial bone extracts. The magnitudes of IGFBP-5–induced increases in ALP and osteocalcin in parietal bone extracts of IGF-I KO mice were comparable to those seen in C3H mice. In contrast to IGFBP-5, local administration of IGFBP-4 had no significant effect on bone formation in C3H and IGF-I KO mice. These results provide the first direct evidence to our knowledge that IGFBP-5 functions as a growth factor that stimulates its actions in part via an IGF-independent mechanism.
Loss of heterozygosity 4q24 and TET2 mutations associated with myelodysplastic/myeloproliferative neoplasms
Authors: Anna M. Jankowska, Hadrian Szpurka, Ramon V. Tiu, Hideki Makishima, Manuel Afable, Jungwon Huh, Christine L. O'Keefe, Rebecca Ganetzky, Michael A. McDevitt, Jaroslaw P. Maciejewski
Journal: Blood (2009)
The treatment of port wine stains with the carbon dioxide laser
Authors: S.W. LANIGAN, J.A. COTTERILL
Journal: British Journal of Dermatology (1990)

The carbon dioxide (CO2) laser was used to treat 51 patients with port wine stains (PWS). Twenty-nine patients were adults who had failed to respond to argon or continuous wave dye laser therapy and 22 patients were children with pink PWS. Follow-up assessment of 40 patients 12 months after treatment revealed an excellent or good result in 74% of adults and 53% of children. The results in adult‘therapeutic failures’was encouraging and CO2 laser therapy can be advised for this group. Two children had a poor result, one with a hypertrophic sear, and treatment in this age group with the CO2 laser should be considered with caution.
SCURVY COMPLICATING VOMITING OF PREGNANCY
Authors: C. N. Swanson
Journal: JAMA (1927)

Adult scurvy is such an uncommon disease under modern living conditions that each case is of interest in that it reinforces the evidence favoring a vitamin deficiency as the ultimate cause. Its association with vomiting of pregnancy must be exceedingly rare, since I have been unable, in a fairly comprehensive search of the literature, to find a single recorded case. Because of this apparent rarity, I decided to present the following case. <h3>REPORT OF CASE</h3> A white woman, aged 27, entered the hospital, Dec. 12, 1925, complaining of vomiting, general debility and epistaxis. The family history was unimportant, and the past history was essentially negative except for scarlet fever at the age of 7, and two subsequent attacks of inflammatory rheumatism, which were not followed by recognized cardiac disease. The tonsils had been removed, but there had been no other operations. The patient was married in June, 1924.
No trivial pursuit
Authors: Des Spence
Journal: BMJ (2011)

Before multimedia and computers there were times when there was literally nothing on the television for much of the day. Christmas meant new films, no pausing, and no recording. If you missed it, you missed it. In commercial breaks people sprinted to the toilet and spilt tea on the carpet as they hurried back from the kitchen. Androids were futuristic robots, Apple and Blackberry types of fruit, and only birds Twittered. These decades were so boring that we resorted to playing board games. Trivial Pursuit …
Acute and subchronic toxicity of ethylene glycol monobutyl ether.
Authors: T R Tyler
Journal: Environmental Health Perspectives (1984)

The available information on the acute and subchronic toxicity of ethylene glycol monobutyl ether is reviewed. Data from animal studies have been examined from the standpoint of dose-response relationships and the sensitivity of various animal species, including man, to the effects of this chemical. In view of recent findings with other chemically related glycol ethers, particular attention has been given to possible adverse effects on blood and testicular tissue. In evaluating the hazard that this chemical may pose to man, consideration has been given to likely routes of exposure and its irritant properties. It is concluded that the available information continues to support the current ACGIH TWA8-TLV of 25 ppm with a STEL of 75 ppm.
Development of biliary sludge in patients on intensive care unit: results of a prospective ultrasonographic study.
Authors: F E Murray, S J Stinchcombe, C J Hawkey
Journal: Gut (1992)

Biliary sludge may be a precursor of gall stones in man. The aim of this study was to determine the incidence of biliary sludge in a prospective study of 36 patients admitted to the intensive care unit for longer than two days. The presence of biliary sludge was determined by ultrasonography. Biliary sludge developed in 17 patients (47%), after a mean of 5.5 days in the intensive care unit. Patients who developed biliary sludge spent longer in the intensive care unit (14.2 d (1.3)), compared with patients who did not (8.3 d (1.4)); (p = 0.003). Ten of the patients with biliary sludge had a recognised risk factor: total parenteral nutrition (five), abdominal surgery (two), or both (three). All neurosurgical patients (four) who required total parenteral nutrition developed biliary sludge. Seven patients with biliary sludge had no previously recognised risk factor, five of whom had severe head trauma or neurosurgery. In conclusion, biliary sludge develops frequently and rapidly in patients admitted to an intensive care unit. Neurosurgical procedures are associated with biliary sludge formation. (Sludge is commonly associated with the development of cholestatic liver biochemistry.)
Methotrexate Therapy in Rheumatic Disease
Authors: M G Ridley
Journal: Annals of the Rheumatic Diseases (1990)

Book reviewsemphasises in a chapter on epidemiology the need for defining terms, going back to clinical observation, and defining out- come-not quite saying forget about the past and start afresh, but not far from that.Epidemiology is one methodology.Another is clinical trial, but the book does not emphasise which studies were controlled and which were not.A third problem is development of concepts.The chapter on fibromyalgia is an excellent review of a developing concept, which explores possible psychological, neurological, and viral abnormality, but puts it in the context of clinical observation and the controversy about its very existence.It highlights the experimental work of Kellgren and Lewis, confirmed later by Hockaday, on pain response to muscle injection with saline-experimental work, repeated by an independent observer and largely forgotten by the following generation of rheumatologists.A similar chapter on repetitive strain injury is sadly absent.Next time we set off into the outback to investigate the unmanned frontier it would be helpful to remember the controlled trial-possibly send an epidemiologist.A look at the maps of those who have been before should induce a healthy scepticism of early explorers.The conference on soft tissue disorders goes some way towards getting that perspective, but sadly does not reference Norton Hadler's review of regional musculoskeletal disorders,' which gives a more balanced view, but is a more expensive guide.
Elevated Flk1 (Vascular Endothelial Growth Factor Receptor 2) Signaling Mediates Enhanced Angiogenesis in β3-Integrin–Deficient Mice
Authors: Andrew R. Reynolds, Louise E. Reynolds, Tobi E. Nagel, Julie C. Lively, Stephen D. Robinson, Daniel J. Hicklin, Sarah C. Bodary, Kairbaan M. Hodivala-Dilke
Journal: Cancer Research (2004)

Tumor growth, tumor angiogenesis, and vascular endothelial growth factor (VEGF)-specific angiogenesis are all enhanced in beta(3)-integrin-null mice. Furthermore, endothelial cells isolated from beta(3)-null mice show elevated levels of Flk1 (VEGF receptor 2) expression, suggesting that beta(3)-integrin can control the amplitude of VEGF responses by controlling Flk1 levels or activity. We now show that Flk1 signaling is required for the enhanced tumor growth and angiogenesis seen in beta(3)-null mice. Moreover, beta(3)-null endothelial cells exhibit enhanced migration and proliferation in response to VEGF in vitro, and this phenotype requires Flk1 signaling. Upon VEGF stimulation, beta(3)-null endothelial cells exhibit higher levels of phosphorylated Flk1 and extracellular-related kinases 1 and 2 than wild-type endothelial cells. Furthermore, signaling via ERK1/2 is required to mediate the elevated responses to VEGF observed in beta(3)-null endothelial cells and aortic rings in vitro. These data confirm that VEGF signaling via Flk1 is enhanced in beta(3)-integrin-deficient mice and suggests that this increase may mediate the enhanced angiogenesis and tumor growth observed in these mice in vivo.