tbuckley/cabot-search huggingface dataset:
INTRACORONARY ADMINISTRATION OF ALLOGENEIC ADIPOSE TISSUE-DERIVED STEM CELLS IN A PORCINE MODEL OF ACUTE MYOCARDIAL INFARCTION: STUDY OF IMMUNE RESPONSE AND TIMING OF ADMINISTRATION
Authors: Magdalena Heras, N&uacute;ria Solanes, Santiago Roura, Merc&egrave; Roqu&eacute;, Ana Paula Dantas, Laura Novens&agrave;, Jaume Martorell, Marta Sitges, Jos&eacute; Ram&iacute;rez, Antoni Bay&eacute;s-Gen&iacute;s, Montserrat Rigol, Hospital Cl&iacute;nic
Journal: Journal of the American College of Cardiology (2012)
Nurse Clinics and Progressive Ambulatory Patient Care
Authors: Charles E. Lewis, Barbara A. Resnik
Journal: New England Journal of Medicine (1967)

THE increasing demand for health-care services in the United States has been documented in several studies. The obvious solution, more manpower in all disciplines, is somewhat unrealistic. In all probability, the demand for health services, as presently organized, cannot be met at the rate that current education programs in the health professions can be expanded or replicated.1 There is considerable discussion regarding the delegation of certain aspects of medical care to new types of health professionals as a means of increasing the quantity of services available. Another possibility is to define more adequately the roles of existing disciplines, on the . . .
Broadband learning for doctors
Authors: James Johnson, Stella Dutton, Edward Briffa, Dame Carol Black
Journal: BMJ (2006)

Has huge potential but needs funding for high quality content 

B roadband internet has finally come of age. It's changing the way we listen to music and radio, and it means we can watch television on demand. What could broadband internet do for medical education?

Early signs suggest that rapid change is underway, led by the learners. In the United States 14% of the credit hours for continuous medical education in 2004 were obtained online, double the figure for two years before.1 In this country BMJ Learning has tapped into this demand, attracting more than 60 000 registered users in less than three years.2

Broadband could offer learners in medicine the next generation of online learning: the prospect of high quality interactive video and audio alongside traditional text and photographs. Audiovisual materials would bring many advantages: they are easy to watch, add realism, and can enable learning of procedural and interpersonal skills. Younger doctors are digital natives and will increasingly expect such materials as the norm.

But …
The problem with using number of primary care consultations before cancer diagnosis
Authors: P. J. R. Taylor
Journal: BMJ (2015)

Use of the number of relevant consultations in primary care before a cancer diagnosis is problematic.1

Consultations can be counted only retrospectively, which could lead to an incorrect assumption about the index consultation. After diagnosis of lung cancer, an initial consultation in a male smoker for a winter cough might be counted, even though referral at …
Duplication, Dicistronic Transcription, and Subsequent Evolution of the Alcohol dehydrogenase and Alcohol dehydrogenase-related Genes in Drosophila
Authors: Esther Betrán, Michael Ashburner
Journal: Molecular Biology and Evolution (2000)

It has recently been discovered that the Alcohol dehydrogenase and Alcohol dehydrogenase–related genes of Drosophila melanogaster and closely related species constitute a single transcription unit and that the Alcohol dehydrogenase–related gene is exclusively expressed from a dicistronic mRNA. Here, we show that in Drosophila lebanonensis, subgenus Scaptodrosophila, Adhr is also transcribed as a dicistronic transcript with Adh. Using degenerate primers designed on the sequence of the known ADHR proteins, we have been able to amplify and sequence a partial sequence of Adhr in species representative of the whole subgenus Drosophila. This has allowed the study of the organization and expression of Adhr in Drosophila buzzatii. We find that in D. buzzatii Adhr is transcribed as a monocistronic transcript. Adh and Adhr are believed to originate by duplication, and our data suggest that the cotranscription of these two genes was the primitive state, and that their independent transcription in the subgenus Drosophila is derived. We can rationalize the D. buzzatii condition as being correlated with the two genes evolving independent transcriptional control. However, why these two genes with clear divergence in the functions of their proteins should remain cotranscribed in groups as divergent as the subgenus Sophophora and the subgenus Scaptodrosophila remains a mystery.
Hypertrophic osteoarthropathy following aortic surgery.
Authors: F Dellestable, P Pere, D Regent, A Gaucher
Journal: Annals of the Rheumatic Diseases (1996)

Unilateral lower extremity hypertrophic osteoarthropathy may be the initial symptom of an infected aortic graft. Knowledge of this uncommon association should lead to early and accurate diagnosis and appropriate surgical management, thus avoiding the development of aortoenteric fistula, a complication that still carries a significant risk of mortality.
Persistence of Subgenomes in Paleopolyploid Cotton after 60 My of Evolution
Authors: Simon Renny-Byfield, Lei Gong, Joseph P. Gallagher, Jonathan F. Wendel
Journal: Molecular Biology and Evolution (2015)

The importance of whole-genome multiplication (WGM) in plant evolution has long been recognized. In flowering plants, WGM is both ubiquitous and in many lineages cyclical, each round followed by substantial gene loss (fractionation). This process may be biased with respect to duplicated chromosomes, often with overexpression of genes in less fractionated relative to more fractionated regions. This bias is hypothesized to arise through downregulation of gene expression through silencing of local transposable elements (TEs). We assess differences in gene expression between duplicated regions of the paleopolyploid cotton genome and demonstrate that the rate of fractionation is negatively correlated with gene expression. We examine recent hypotheses regarding the source of fractionation bias and show that TE-mediated, positional downregulation is absent in the modern cotton genome, seemingly excluding this phenomenon as the primary driver of biased gene loss. Nevertheless, the paleo subgenomes of diploid cotton are still distinguishable with respect to TE content, targeting of 24-nt-small interfering RNAs and GC content, despite approximately 60 My of evolution. We propose that repeat content per se and differential recombination rates may drive biased fractionation following WGM. These data highlight the likely importance of ancient genomic fractionation biases in shaping modern crop genomes.
A 47-Year-Old Woman With Ductal Carcinoma In Situ
Authors: Monica Morrow
Journal: JAMA (1996)

<h3>Dr Daley:</h3> Mrs Y is a 47-year-old teacher. Married and the mother of two children, she lives in suburban Boston, Mass. She is covered by private health insurance through her husband's employer. The patient has been healthy, with no prior surgeries or hospitalizations other than childbirth. She has had no medical problems except for a left breast biopsy many years ago. She takes no medications. She is gravida 2, para 2, abortus 0, with regular menstrual periods. Her family history is significant for her mother, who was diagnosed with breast cancer at 61 years of age and died 4 years after her initial diagnosis with widespread metastases. Given her family history, Mrs Y has been conscientious about breast self-examination and undergoing screening mammography regularly. In June 1995, the patient had a screening mammogram that showed microcalcifications in the left breast. There was no palpable mass. After review, the mammographer recommended
"HEAVY WATER" AND TUMOR GROWTH
Authors: WILLIAM H. WOGLOM
Journal: JAMA (1934)

Pursuant to a suggestion by Prof. Harold C. Urey, the effect of "heavy water" on tumor growth has been investigated. This liquid consists of water in which ordinary hydrogen, of mass 1, has been replaced by its isotope, deuterium ("heavy hydrogen"), of mass 2.<sup>1</sup>When replacement is complete, the substance is no longer water but deuterium oxide, quite another material with specific gravity, vapor pressure, and freezing and boiling points differing from those of water. High concentrations, such as have been shown detrimental to lower forms of animal life and to seeds, could not be employed in the projected experiment, however, on account of their cost, and it was necessary to be content with a preparation in which somewhat less than 0.5 per cent (from 0.40 to 0.42 per cent, according to determinations made by one of us) of the hydrogen was deuterium. Still, as ordinary water has but
Book: Privacy and Confidentiality in Mental Health Care
Authors: C. U Iacono
Journal: BMJ (2001)

Eds John J Gates, Bernard S Arons P H Brookes, £27.50, pp 272 ISBN 1 55766 426 9 Rating: ![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img> Gates and Arons discuss issues of confidentiality and privacy in the United States in relation to mental health services for adults and children, law and ethics, technology, substance misuse, and the patient's family. One is left with the impression that there is no uniform “protection under the law” regarding the privacy and confidentiality of mental health records … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif
Hepatocyte-specific deletion of Cdc42 results in delayed liver regeneration after partial hepatectomy in mice
Authors: Haixin Yuan, Hong Zhang, Xunwei Wu, Zhe Zhang, Dan Du, Wenchao Zhou, Shuhua Zhou, Cord Brakebusch, Zhengjun Chen
Journal: Hepatology (2008)

Cdc42, a member of the Rho guanosine triphosphatase (GTPase) family, plays important roles in the regulation of the cytoskeleton, cell proliferation, cell polarity, and cellular transport, but little is known about its specific function in mammalian liver. We investigated the function of Cdc42 in regulating liver regeneration. Using a mouse model with liver-specific knockout of Cdc42 (Cdc42LK), we studied liver regeneration after partial hepatectomy. Histological analysis, immunostaining, and western blot analysis were performed to characterize Cdc42LK livers and to explore the role of Cdc42 in liver regeneration. In control mouse livers, Cdc42 became activated between 3 and 24 hours after partial hepatectomy. Loss of Cdc42 led to a significant delay of liver recovery after partial hepatectomy, which was associated with reduced and delayed DNA synthesis indicated by 5-bromo-2′-deoxyuridine staining. Consistent with this, expression of cyclins D1, A, and E was markedly delayed or reduced in Cdc42LK livers during regeneration. As a potential effector of Cdc42, Rac1 activation was dramatically attenuated in Cdc42LK livers after partial hepatectomy, suggesting it is regulated in a Cdc42-dependent manner. Activation of certain proliferative signaling pathways, such as extracellular signal–regulated kinase, c-Jun N-terminal kinase, and p70S6 kinase pathways, was delayed in Cdc42LK livers. In addition, dilated bile canaliculi and excessive lipid accumulation were observed in mutant livers during liver regeneration, which may result from impaired cytoskeletal organization and intracellular trafficking in hepatocytes. Conclusion: Our results revealed important roles of Cdc42 in the regulation of proliferative signaling during liver regeneration. (HEPATOLOGY 2009:49:240-249.)
Accumulation of Tc-99m MDP in Amyloidosis Involving the Tongue
Authors: TIMOTHY S. BURKE, JAMES L. TATUM, MELVIN J. FRATKIN
Journal: Clinical Nuclear Medicine (1990)

Radionuclide bone imaging using Tc-99m phosphates may show accumulation of activity in amyloid deposits. While many sites of amyloidosis have been detected with bone imaging, many reports center on cardiac amyloidosis. The case reported here demonstrates accumulation of Tc-99m MDP in amyloidosis involving the skin and muscle, including the tongue.
LARGE ORIFICE AND DECREASED FLOW VELOCITY OF LEFT ATRIAL APPENDAGE ARE STRONG PREDICTORS OF STROKE IN NON-VALVULAR ATRIAL FIBRILLATION
Authors: Jung Myung Lee, Jaemin Shim, Jae-Sun Uhm, Hui-Nam Pak, Moon-Hyoung Lee, Boyoung Joung
Journal: Journal of the American College of Cardiology (2013)
Long-Term Predictors of Descending Aorta Aneurysmal Change in Patients With Aortic Dissection
Authors: Jong-Min Song, Sung-Doo Kim, Jeong-Hoon Kim, Mi-Jeong Kim, Duk-Hyun Kang, Joon Beom Seo, Tae-Hwan Lim, Jae Won Lee, Meong-Gun Song, Jae-Kwan Song
Journal: Journal of the American College of Cardiology (2007)
P564 ‘LATE WASHOUT’ ON THE HEPATOSPECIFIC PHASE OF Gd-BOPTA MRI IN THE CHARACTERISATION OF ARTERIAL-ENHANCING HCCS LACKING WASHOUT ON THE PORTAL VENOUS AND EQUILIBRIUM PHASES
Authors: K. Cortis, R. Liotta, R. Miraglia, S. Caruso, F. Tuzzolino, A. Luca
Journal: Journal of Hepatology (2014)
The “bias” bias in social psychology: Adaptive when and how?
Authors: James Friedrich
Journal: Behavioral and Brain Sciences (2004)

In following the form of a standard “bias” paper, the authors highlight a potentially serious bias of uncertain magnitude. A negative focus in research has certain adaptive features in terms of professional and public support, as well as theory generation. The bias deserves attention and correction, but in ways that do not exaggerate its liabilities or overlook its virtues.
CORRELATION OF CLINICAL, ROENTGENOLOGIC AND SEROLOGIC EVIDENCES OF RICKETS IN BREAST-FED
Authors: L. R. DeBUYS
Journal: JAMA (1924)

The clinical signs of rickets have been familiar to observers for many generations, and up to a half decade ago constituted the sole diagnostic criteria for the clinician. There have recently been added to our knowledge the characteristic roentgenographic picture and the chemical changes in the blood. Many of us, no doubt, have encountered certain cases presenting some evidences of rickets, but we have been in doubt as to the actual presence of the disease. Particularly is this true of the breast-fed baby, reared in healthy surroundings, with every possible comfort, and whose nutrition seems to be beyond criticism. Indeed, we have never been sure just which clinical signs, if any, were infallible as diagnostic points of the disease. It is generally believed that, in the absence of scurvy, beading of the ribs is the earliest and most reliable sign, while there are many who attach to craniotabes a pathognomonic
Phagocyte receptors for apoptotic cells: recognition, uptake, and consequences
Authors: Valerie A. Fadok, Donna L. Bratton, Peter M. Henson
Journal: Journal of Clinical Investigation (2001)

Apoptosis, a genetically programmed cell death conserved throughout phylogeny, provides a counterbalance to mitosis in the regulation of tissue growth and homeostasis (1, 2). Interest in and knowledge of the mechanisms mediating the induction and execution of the death program have blossomed in the last decade and a half. Engulfment of apoptotic bodies and debris represents the denouement of the death program for most cells in multicellular organisms.

Macrophages and other cells manifesting their primitive phagocytic potential clear apoptotic bodies from tissues, preventing their lysis and the consequent release of toxic or immunogenic intracellular components. By inducing the release of mediators such as TGF-β, IL-10, prostaglandin E2 (PGE2), and others, clearance of apoptotic cells also sets up an anti-inflammatory milieu within the tissue (reviewed in refs. 3, 4). However, phagocytic clearance is not merely a silent process with respect to inflammation and immunity but is also actively anti-inflammatory. In spite of its critical importance to tissue and host homeostasis, clearance of apoptotic cells is poorly understood, and studies devoted to elucidating the mechanisms mediating recognition and engulfment have lagged behind those probing the induction and execution of the death process itself. This situation is finally changing as we begin to unravel the mechanisms mediating clearance of apoptotic cells.

Many of the macrophage receptors that contribute to apoptotic cell recognition are critical players in innate immunity. These include certain lectins and integrins, the class A and class B scavenger receptors (see Platt and Gordon, this Perspective series, ref. 5; and Krieger, this series, ref. 6), receptors for oxidized LDL, including CD68 and lectin-like oxidized LDL receptor-1 (LOX-1), some of the receptors for complement-derived proteins, and the endotoxin receptor CD14 (reviewed in ref. 7). Paradoxically, however, when microbial organisms or their products are engulfed via these receptors, inflammation results, and in many cases, acquired immunity is stimulated. In contrast, uptake of apoptotic cells is generally noninflammatory and thereby avoids activation of an acquired immune response. Our task is to understand and explain these diametrically opposed reactions to stimulation of the same receptors.
Psychiatric Findings in Cardiotomy Patients
Authors: DAVID RUBINSTEIN, JOHN K. THOMAS
Journal: American Journal of Psychiatry (1969)

Thirty-six patients who underwent open heart surgery were given preoperative psychiatric evaluations to determine whether postoperative expressions of delirium might be related to preexisting but covert psychiatric illness. Findings included a poor postoperative prognosis for patients with preoperative organic brain syndrome and a relatively high incidence of postcardiotomy delirium among those who had preoperative psychiatric symptoms. The authors suggest the use of more refined projective techniques to detect minimal organic impairment that might carry an increased risk of postoperative morbidity and mortality. Also, with more definitive parameters for determining preoperative psychiatric difficulties, they conclude, the predictability of postcardiotomy delirium may be enhanced.
Interaction of antibiotics with vitamin K
Authors: F. Rodriguez-Erdmann
Journal: JAMA (1981)

<h3>To the Editor.—</h3> The increasing population of senior citizens is currently viewed by our political structure as a cultural and financial liability, a burden that we are obliged to carry. Instead, these senior citizens represent an untapped national resource from which both cultural and financial dividends are obtainable. We have recognized one area in which senior citizens are able to play an important and otherwise unfulfilled role. Three years ago, the Experimental Lung Transplant Laboratory Group in conjunction with the Department of Volunteer Services at Montefiore Hospital and Medical Center-Albert Einstein College of Medicine (NY) became aware of the senior citizen as a resource and thereby recognized a potential solution to the rapidly shrinking value of the available research dollar. As a result of this awareness, six senior citizen volunteers have joined our staff and regularly perform a wide range of duties. In our laboratories, a retired dentist has designed
Linear and whorled naevoid hypermelanosis: a case with systemic involvement and trisomy 18 mosaicism
Authors: M. Komine, M. Hino, M. Shiina, I. Kanazawa, Y. Soma, K. Tamaki
Journal: British Journal of Dermatology (2002)

Summary We describe a 20‐year‐old woman with trisomy 18 mosaicism, who presented with skeletal anomalies, epilepsy, mental retardation, and linear and whorled naevoid hypermelanosis.
Spontaneous Osteoporotic Fracture of the Sacrum
Authors: Herbert Lourie
Journal: JAMA (1982)

Three elderly patients with incapacitating back and leg pain were found to have spontaneous osteoporotic fractures of the sacrum. The clinical picture in these three patients suggests a distinct clinical entity of spontaneous osteoporotic fracture of the sacrum (SOFS). This is characterized by severe low back, hip, and leg pain that suggests initially lumbosacral radicular compression, either from disk disease, spinal stenosis, tumor. However, objective mechanical signs more typical of those entities may be absent or minimal in SOFS. Symptoms suggestive of a cauda equina syndrome may be present, but there is minimal or no neurological deficit on examination. Marked sacral tenderness is a hallmark of SOFS.
Correction: Cancer Chemotherapy Protocols and Dose of Chlorambucil
Authors: Robert J. Ignoffo, Peter Forni
Journal: Annals of Internal Medicine (1989)

Letters and Corrections15 September 1989Correction: Cancer Chemotherapy Protocols and Dose of ChlorambucilRobert J. Ignoffo, PharmD, Peter Forni, PharmDRobert J. Ignoffo, PharmDSearch for more papers by this author, Peter Forni, PharmDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-111-6-543_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:We wish to inform the readers of an error in the reference book titledCancer Chemotherapy Protocolsby R. Ignoffo and P. Forni. This handbook was given out to health care professionals at the recent ONS, ASCO, and ASHP annual meetings as an educational service by Cetus Corporation. In section 7 of "Chronic Leukemias" (the pulse CP regimen), the dose of chlorambucil should be 0.4 mg/kg po day 1 every other week, not 0.4 mg/kg po qd every other week. The prednisone dose is still 100 mg po days 1 to 7 every other week. We apologize... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 September 1989Volume 111, Issue 6Page: 543-543KeywordsCancer chemotherapyHealth careHeart rateLeukemia Issue Published: 15 September 1989 PDF downloadLoading ...
Oesophageal reflux and asthma
Authors: JG Ayres, JF Miles
Journal: European Respiratory Journal (1996)

Asthma and gastro-oesophageal reflux commonly occur together but the association in any individual may or may not be causal. Aspiration of gastric acid into the trachea has been demonstrated in some patients with asthma with concomitant falls in lung function, while acid in the lower oesophagus can exacerbate asthma by a vagal reflex following stimulation of lower oesophageal receptors. Conversely, asthma can lead to worsening reflux both through the use of smooth muscle relaxing anti-asthma medication and by the mechanical effects of hyperinflation reducing lower oesophageal sphincter pressures. The effects on asthma following treatment of reflux has been anecdotally reported to be successful in some individuals, particularly those with severe reflux, but surgery should be reserved for individuals only after failure of medical treatment and should be aimed at improving reflux symptoms rather than improving asthma control.
An In Vivo RNAi Screening Approach to Identify Host Determinants of Virus Replication
Authors: Andrew Varble, Asiel A. Benitez, Sonja Schmid, David Sachs, Jaehee V. Shim, Ruth Rodriguez-Barrueco, Maryline Panis, Marshall Crumiller, Jose M. Silva, Ravi Sachidanandam, Benjamin R. tenOever
Journal: Cell Host & Microbe (2013)
Technic in Agglutination Tests.
Authors: Oscar Klotz
Journal: JAMA (1905)

Montreal, May4, 1905. <h3>To the Editor:</h3> In a letter just received Dr. F. F. Wesbrook points out to me that I have credited him in my paper on agglutination (The Journal, April 22, 1905, p. 1261) with<i>devising</i>a method for making accurate dilutions from dried blood in agglutination tests, whereas the method was<i>suggested</i>by him while the originality and perfecting of the<i>technic</i>belongs to Dr. Wilson. I should be very pleased if you would make this correction in your columns.
Oral sirolimus to prevent restenosis after stenting de novo coronary lesions
Authors: Costantino R. Costantini, Daniel Zanuttini, Sergio Tarbine, Rubens Darwich, Jose L. Lazarte, Costantino O. Costantini, Mario Maranhao, Manuel Andrade, Maria R. Oliveira, Luis Sabattini, Gilson Yared, Marco Bubna, Marco Medeiro, Lauro Rubbini, Marcelo Freitas
Journal: Journal of the American College of Cardiology (2003)