tbuckley/cabot-search huggingface dataset:
Frederic S. Dennis and Penicillium Glaucum
Authors: John H. Mulholland
Journal: JAMA (1970)

<h3>To the Editor.—</h3> In 1885 the Carnegie Laboratory for medical research of the Bellevue Hospital Medical College was opened. It was the first structure built for medical research purposes in this country. Doctor Frederick S. Dennis, a surgeon, reported the initial investigations carried out in the laboratories in a paper entitled "The Action of Micro-organisms Upon Surgical Wounds" published in<i>The Transactions of The New York Medical Association</i>(<b>2</b>:377-414, 1886). In a discussion of contaminants from laboratory air in culture media the following appears: The most common variety of living organisms found upon the beef infusion is the<i>Penicillium glaucum</i>... with all my precaustions, I have failed in a series of interesting experiments by reason of (Koch's) jelly being impregnated with germs in the air in the laboratory while in the act of pouring the jelly from a sterilized vessel into capsules. Instead of the<i>Penicillium glaucum</i>, bacteria may
Abstract 441: Temporal profiling of a breast cancer cell line MCF-7 in response to reoxygenation
Authors: Kuo Chin Chen, Mong Hsun Tsai, Eric Y. Chuang, Chuhsing Kate Hsiao, Liang Chuan Lai
Journal: Cancer Research (2010)

Abstract Oxygen fluctuation resulting from hyper-proliferation of tumor cells, abnormal metabolism and disorganized tumor neovasculature characterizes the microenvironment of many cancers, which influences tumor development and angiogenesis. Furthermore, this condition increases chemo-resistance and radio-resistance of tumor cells, and also associates with increased invasion and metastatic potential accompanied with a poor prognosis. Hypoxia/ reoxygenation induce oxidative stress, which leads to DNA damage and genomic instability. It is known that multiple cellular responses were activated in order to survive under this microenvironment, but little is known about the dynamic response upon reoxygenation. To investigate the dynamic response of signalling pathways in tumor adaptation, a breast cancer cell line MCF-7 was cultured under 0.5% oxygen condition 24 hours followed by reoxygenation, and was harvested at various time points during reoxygenation. Genome-wide microarray results revealed that 274 genes were differentially expressed during reoxygenation; 47.4% of them were up-regulated and 52.3% down-regulated. Furthermore, pathway analysis, including canonical pathway and gene network, were performed using Ingenuity Pathway Analysis. Selected genes of interest were validated by quantitative real-time PCR, such as hexokinase 2 (HK2) and cyclin D3 (CCND3). Survival analysis using clonogenic assay showed little effect of reoxygenation on MCF-7 cells, but proliferation was inhibited upon reoxygenation. Our result showed dynamic changes of MCF-7 gene expression and molecular pathways unpon reoxygenation, which shed some light on understanding of tumor adaptation. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 441.
P3-14-23: Response to Neoadjuvant Chemotherapy and Survival in Japanese Patients with Triple-Negative Breast Cancer.
Authors: S Ohtani, M Kochi, M Ito, S Takada, H Matsuura, K Higaki
Journal: Cancer Research (2011)

Abstract Background Triple-negative breast cancer (TNBC) is defined by the lack of estrogen receptor (ER), progesterone receptor (PgR), and human epidermal growth factor receptor 2 (HER2)expression. In this study, we compared response to neoadjuvant chemotherapy and survival between Japanese patients with TNBC and non-TNBC. Patients and Methods Analysis of a prospectively collected clinical database was performed. We analyzed 335 Japanese patients who received neoadjuvant chemotherapy at Hiroshima City Hospital for stage I-III breast cancer from 2002–2010. Clinical and pathological parameters, pathological complete response (pCR) rates, survival measurements, and organ specific relapse rates were compared between with TNBC and non-TNBC. Results: 21.1% had TNBC. Patients with TNBC compared with non-TNBC had not significantly higher pCR rate (28% v 19%; p=0.09), similar disease progression-free survival (DFS) rate (p=0.59), but decreased overall survival (OS) rate (p=0.02). TNBC was associated with increased risk for visceral metastasis (p&amp;lt;0.0001) and shorter postrecurrence survival (p=0.017). If pCR was achieved, patients with TNBC and non-TNBC had similar survival. In contrast, patients with residual disease (RD) had worse OS if they had TNBC compared with non-TNBC (p=0.01). Conclusion: TNBC patients with pCR after neoadjuvant chemotherapy have excellent survival. However, TNBC patients with RD have significantly worse survival, compared with non-TNBC patients with RD. Japanese patients with TNBC have also similar results with those in other ethnic group reported before. Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr P3-14-23.
INTERSTITIAL IMMUNE COMPLEX THYROIDITIS IN MICE
Authors: James A. Clagett, Curtis B. Wilson, William O. Weigle
Journal: The Journal of Experimental Medicine (1974)

Mice immunized with soluble heterologous thyroglobulins developed autoantibody that cross-reacted with autologous thyroglobulin. There was a direct correlation between the temporal appearance and quantity of serum autoantibody and the presumed in situ formation of immune complexes in the interstitium of the thyroid glands. Immediately after the formation of interstitial immune complexes containing antibody of the IgG complement-fixing type, the thyroids were invaded by a transient but intense neutrophil infiltrate which within 1 wk was replaced by chronic mononuclear elements. By the combination of fluorescence microscopy and autoradiography, thyroglobulin was demonstrated to be one, if not the sole, antigen in the interstitial immune complexes. The interstitial immune complexes were granular to lumpy in appearance and formed at the basal area of the follicular cells in intimate association with the follicular basement membrane. Electron microscopy revealed electron dense deposits, presumably immune complexes, between the follicular basement membrane and the plasma membrane. The presumed in situ formation of immune complexes in this model is similar to that which occurs in the Arthus reaction and is a different mechanism of immune complex injury than that caused by tissue deposition of circulating immune complexes as occurs in serum sickness.
Treating the Poor: A Personal Sojourn Through the Rise and Fall of Community Mental Health
Authors: Carl C. Bell
Journal: JAMA (1994)

The subtitle of this book, "A Personal Sojourn Through the Rise and Fall of Community Mental Health," adequately describes its focus. The author is a witty, biting, and compassionate physician who embraced the philosophy of community psychiatry as it was conceived in the 1960s. The book is filled with clinical vignettes and anecdotes that embody the principles of community psychiatry. Organized psychiatry would do well to heed these words of wisdom. Psychiatry's sole emphasis on the biology of the brain is felt by the author to be arrogant in its assumptions and limiting in that it obstructs the ability to think contextually. As a result, there has been an inattention to issues of ethnicity, social class, and other realities of life. There is acrimonious condemnation of spending resources on patients with interesting and rare diseases rather than addressing common problems in the community. Dr Dumont's personal experiences, including working with
Exogenous Insulin and Hypoglycemia as Prognostic Factors in Critically Ill Patients
Authors: Iwan C. C. van der Horst, Rijk O. B. Gans, Felix Zijlstra, Jack J. M. Ligtenberg
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Novel Antinuclear Antibody Associated with a Lupus-like Paraneoplastic Syndrome
Authors: Bruce Freundlich
Journal: Annals of Internal Medicine (1988)

The association of malignancy with lupus-like syndromes is rare, and the relation between these two processes is uncertain. A 71-year-old woman who presented with serositis, Raynaud phenomenon, and positive results on an antinuclear antibody test was initially thought to have systemic lupus erythematosus but was found to have ovarian adenocarcinoma. A unique sparsely speckled antinuclear antibody pattern was seen. The patient's sera reacted to novel antigens with six bands of 100, 80-78, 48, and 17 kD on Western blots not typical of reactivity for sera from patients with systemic lupus erythematosus.
Working group identifies NHS priorities
Authors: C Court
Journal: BMJ (1994)

The need for efficient communication between primary and secondary care in Britain has become more urgent since the changes in health care delivery, according to a new report. The comprehensive transfer of information between the two levels of care tops the list of priorities outlined in the report, which was produced for the NHS central research and development committee.

Twenty one NHS priority areas are identified in the report, which examined priorities in research and development in relation to …
Has child protection become a form of madness? Yes and No
Authors: D. W. Jones
Journal: BMJ (2011)

Has child protection become a form of madness, as the BMJ recently debated?1 2 In response to the authors’ points, the answer is both “yes” and “no.” Yes, we need to focus on the underlying causes that disadvantage children and that in the process may place children at the risk of abuse; but no, …
Serum Interleukin-6 Correlates With Endothelial Dysfunction in Healthy Men Independently of Insulin Sensitivity
Authors: Eduardo Esteve, Antoni Castro, Abel López-Bermejo, Joan Vendrell, Wifredo Ricart, Jose-Manuel Fernández-Real
Journal: Diabetes Care (2007)

Interleukin (IL)-6 is a proinflammatory cytokine that is implicated in the pathogenesis of atherosclerosis and insulin resistance. Both endothelial dysfunction and insulin resistance are among the earliest abnormalities that can be detected in people at risk for cardiovascular events. We aimed to evaluate whether increased serum IL-6 concentrations associated with endothelial dysfunction are independent of insulin sensitivity in apparently healthy men.Association studies were performed in well-characterized nondiabetic Caucasian men (n = 99) recruited for energy balance studies. Insulin sensitivity (minimal model) and brachial vascular reactivity (high-resolution external ultrasound) were assessed. Circulating IL-6 concentrations were measured by enzyme-linked immunosorbent assay.Serum IL-6 was an independent contributor to the variance of endothelium-dependent vasodilatation after adjusting for age, BMI, smoking status, LDL cholesterol, systolic blood pressure, diastolic blood pressure, and insulin sensitivity (P = 0.001). In fact, circulating IL-6 was negatively associated with endothelium-dependent vasodilatation (r = -0.247, P = 0.014) and insulin sensitivity (r = -0.262, P = 0.011) and correlated positively with age (r = 0.241, P = 0.016), BMI (r = 0.240, P = 0.017), systolic blood pressure (r = 0.299, P = 0.003), diastolic blood pressure (r = 0.295, P = 0.003), and triglycerides (r = 0.212, P = 0.035). No significant associations were observed between endothelium-independent vasodilatation and serum IL-6 concentrations.Circulating IL-6 is linked to endothelial dysfunction independently of insulin sensitivity in apparently healthy men.
The Ang-1/Tie2 angiogenic axis is selectively engaged in rheumatoid arthritis (RA) synovial tissue even before ACR criteria of RA are met
Authors: M G H van de Sande, D de Launay, S Krausz, G P M van de Sande, C A Wijbrandts, P P Tak, K A Reedquist
Journal: Annals of the Rheumatic Diseases (2010)

Background Angiogenesis contributes to infl ammation and joint destruction in rheumatoid arthritis (RA).Angiopoietins 1 (Ang-1) and Ang-2, which mediate blood vessel remodelling, as well as their receptor Tie2, are expressed in infl amed synovial tissue.The authors have recently shown that Ang-1 expression relative to Ang-2 is signifi cantly higher in RA compared to psoriatic arthritis, corresponding with enhanced activation of synovial Tie2 in RA.The aim of this study was to determine if Tie2 signalling is selectively engaged early in the development of RA by investigating expression of Ang-1 and Ang-2 and activation of Tie2 in disease-modifying antirheumatic drug (DMARD)-naïve patients with early arthritis.Methods The authors analysed synovial tissue biopsies of 50 DMARD-naïve patients with early arthritis, prospectively followed and diagnosed after 2 years.Quantitative analysis of expression or activation of the angiogenic markers was examined by immunohistochemistry and the results were compared between patients with different diagnoses.Results Ang-1 expression was elevated at baseline in patients diagnosed with RA compared with those with spondyloarthritis (SpA) (p<0.05), while Ang-2 expression was elevated in patients with SpA compared with RA or those with on August 14, 2023 by guest.
799. In Vitro and In Vivo Characterization of “Second-Generation” Co-Stimulatory Chimeric Antigen Receptors (CARs) Targeting the CD19 Antigen Present on B Cell Malignancies
Authors: Renier J. Brentjens, Yan Nikhamin, Miko Matsushita, Michel Sadelain
Journal: Molecular Therapy (2005)
Association Study of the Chromosomal Region Containing the FCER2 Gene Suggests It Has a Regulatory Role in Atopic Disorders
Authors: TARJA LAITINEN, VESA OLLIKAINEN, CONXI LÁZARO, PAULA KAUPPI, RAFAEL de CID, JOSEP MARIA ANTÓ, XAVIER ESTIVILL, HEIKKI LOKKI, HEIKKI MANNILA, LAURI A. LAITINEN, JUHA KERE
Journal: American Journal of Respiratory and Critical Care Medicine (2000)

On the basis of studies with animal models, the gene for the low-affinity receptor for immunoglobulin E (IgE) (FCER2, CD23) has been implicated as a candidate for IgE-mediated allergic diseases and bronchial hyperreactivity, or related traits. Given evidence for genetic complexity in atopic disorders, we sought to study two European subpopulations, Finnish and Catalonian. We studied three phenotypic markers: (1) total serum IgE level; (2) asthma; and (3) specific IgE level for a mixture of the most common aeroallergens in Finland. Altogether, eight polymorphic markers spanning a region of 10 cM around the FCER2 gene on chromosome 19p13 were analyzed in 124 families. The physical order of the markers and the location of the FCER2 gene were confirmed by using radiation hybrids. The allele and haplotype association study showed a suggestive haplotype association (signficance of p ⩽ 0.03 based on a permutation test) for a high serum IgE response. In a subset of chromosomes segregating with asthma in families with two or more affected members, a single haplotype was found to be highly enriched (p = 8.3 × 10− 6). However, sequence polymorphisms, which would verify structural differences in the FCER2 gene, were not detected in the coding region of the receptor. Our results suggest that chromosome 19p13 might harbor a genetic determinant of IgE-related traits. Studies in other population samples are needed to verify this finding. Laitinen T, Ollikainen V, Lázaro C, Kauppi P, de Cid R, Antó JM, Estivill X, Lokki H, Mannila H, Laitinen LA, Kere J. Association study of the chromosomal region containing the FCER2 gene suggests it has a regulatory role in atopic disorders.
739. Bioluminescent Virion Shells: A Novel Tool for Visualization of Viral Vectors in Animal Tissue
Authors: Aravind Asokan, Jarrod S. Johnson, Richard J. Samulski
Journal: Molecular Therapy (2006)

Current technologies for visualizing the infectious pathway of viruses and viral vectors are primarily focused on fluorescent protein fusion constructs that are not ideally suited for non-invasive live animal imaging. We have engineered bioluminescent Gaussia luciferase-tagged Adeno-Associated Viral (gLuc-AAV) capsids to visualize the spatio-temporal dynamics of vector distribution within mammalian tissue in vivo. Gaussia luciferase, the smallest known luciferase (19.9kD), displays enzymatic activity several orders of magnitude higher than Renilla and Firefly luciferase(s) and was incorporated into recombinant AAV capsids by fusion to the N- terminus of the VP2 capsid subunit. Mosaic gLuc-AAV capsids were morphologically and functionally indistinguishable from wild type AAV vectors. The kinetics of cell surface binding and internalization of gLuc-AAV type 2 vectors in vitro was determined using luminescence spectroscopy. Following intramuscular administration, bioluminescent gLuc-AAV type 2 vectors were easily visualized in mouse skeletal muscle subsequent to systemic or intramuscular injection of the luciferase substrate, coelenterazine. The novel technology described herein will be particularly useful in understanding vector spread and uptake within different tissues and establishing the safety of viral vectors for gene therapy.
Measurement of Psychological and Heart Rate Reactivity to Stress in the Real World
Authors: Patricia L. Dobkin, Robert O. Pihl
Journal: Psychotherapy and Psychosomatics (1992)

The purpose of the present investigation was to develop and test an innovative methodology to assess stress reactivity in the real world. A portable microcomputer was programmed to administer two questionnaires eight times per day for 3 days in the field. Heart rate was measured simultaneously using a reliable and valid ambulatory monitor (Sport Tester PE-3000). Data were analyzed in terms of stress versus no stress, based on subjects' perceptions of the 24 events. It was found that heart rate was significantly higher in the stress condition and that physical stressors contributed significantly to heart rate variability, as did cigarette smoking. Three emotional responses were evident when subjects were stressed: anxiety, hostility and depression; the former two emotions also contributed to heart rate variability. The heart rate data were compared to a number of other studies conducted in the field and found to be strikingly similar. It was concluded that the new technologies currently available allow for the measurement of stress reactivity in the field.
USE OF COBRA POISON THERAPEUTICALLY
Authors: Raymond L. Ditmars
Journal: JAMA (1933)

To the Editor:  —In glancing through the April 29 issue ofThe Journal, under the section devoted to foreign letters, I noted a paragraph relating to the treatment of cancer with cobra poison. In this paragraph it is indicated that Mr. Korossios and Mr. Laignel-Lavastene had made the original research in this direction. May I suggest that, as far as I am aware, it was a New York physician who originally studied the effect of snake poisons in treating certain diseases, including cancer, his work being steadily conducted for the past six years. At his request, I extracted and tendered cobra (Naja) and Crotalus venoms to him during this period, and assisted him in his laboratory with the preparation of the modified cobra poison for injection. Until about a year ago, he steadily supplied Dr. Gosset and Dr. Taguet of Paris with the modified cobra poison with which they conducted
Clinical Studies on Behcet's Syndrome
Authors: Y. Oshima, T. Shimizu, R. Yokohari, T. Matsumoto, K. Kano, T. Kagami, H. Nagaya
Journal: Annals of the Rheumatic Diseases (1963)

Since Behqet (1937) reported cases with the symptoms of skin eruption, ulceration of the mucous membranes, and hypopyon-uveitis, similar cases have been described by many authors (sum- marized by Robinson and McCrumb, 1950) as the "mucocutaneous ocular syndrome".Cases of _
Invariant natural killer T cells in patients with common variable immunodeficiency
Authors: Dominic Paquin-Proulx, Bianca A.N. Santos, Karina I. Carvalho, Myrthes Toledo-Barros, Ana Karolina B. Oliveira, Cristina M. Kokron, Jorge Kalil, Markus Moll, Esper G. Kallas, Johan K. Sandberg
Journal: Journal of Allergy and Clinical Immunology (2014)
Two new glucose‐6 phosphate dehydrogenase (G6PD) variants associated with hemolytic anemia: G6PD amman‐1 and G6PD amman‐2
Authors: Naif S. Karadsheh, A. S. Awidi, M. S. Tarawneh
Journal: American Journal of Hematology (1986)

Two glucose-6-phosphate dehydrogenase (G6PD) variants were investigated. G6PD Amman-1 was partially purified from the red cells of a patient suffering from recurrent jaundice and spontaneous episodic attacks of severe hemolysis in the absence of oxidant drugs, infection, or fava beans. The enzymatic characteristics of G6PD Amman-1 were markedly reduced activity, fast eletrophoretic mobility, slightly increased km for NADP, normal km for G-6-P, normal heat stability, normal utilization of substrate analogues 2-deoxy G-6-P and deamino-NADP, and a monophasic pH curve with a peak at 8.5 to 9.3. The second variant, G6PD Amman-2, was partially purified from the red cells of a patient suffering from recurrent jaundice with episodic mild hemolysis caused by infection or unknown factors. G6PD Amman-2 characteristics were severely reduced activity, slow electrophoretic mobility, normal km for NADP, decreased km for G-6-P, decreased heat stability, increased utilization of substrate analogues, and a monophasic pH curve with a narrow peak at pH 9.5. The red cell level of reduced glutathione was markedly decreased with twofold increase in the activity of glutathione reductase in the patient with G6PD Amman-2.