tbuckley/cabot-search huggingface dataset:
Lichen planus and hepatitis C virus: a multicentre study of patients with oral lesions and a systematic review
Authors: G. Lodi, M. Giuliani, A. Majorana, A. Sardella, C. Bez, F. Demarosi, A. Carrassi
Journal: British Journal of Dermatology (2004)

Background An association between hepatitis C virus (HCV) infection and lichen planus (LP) has been investigated, but results have been inconsistent. Objectives To investigate the relationship between LP and HCV seropositivity. Methods In a cross-sectional study we tested the sera of 303 consecutive newly diagnosed patients with histologically proven LP referred to three Italian centres for the presence of anti-HCV IgG. A comparable control group was also tested. Next, in a systematic review, studies were identified by searching different databases in April 2004. Inclusion criteria were: (i) analytical study design; (ii) clinical and histological diagnosis of LP; and (iii) serological test for anti-HCV antibodies as main outcome. The risk of bias was assessed on the basis of characteristics of the study group, appropriateness of the control group and study design. Pooled data were analysed by calculating odds ratios (ORs), using a random effects model. Results In the cross-sectional study, nearly one in five (19·1%) of the LP group was HCV positive, while a much lower prevalence of infection was found in the control group (3·2%) [OR 7·08; 95% confidence interval (CI) 3·43–14·58]. The systematic review yielded 25 relevant studies, six of which had a low risk of bias. There was a statistically significant difference in the proportion of HCV-seropositive subjects among patients with LP, compared with controls (OR 4·80; 95% CI 3·25–7·09). Following subgroup analyses, the variability of HCV prevalence in patients with LP seemed to depend on geographical area, but not on age. Conclusions Anti-HCV circulating antibodies are more common in patients with LP than in controls, although such an association may not be significant in some geographical areas.
Condylomata Lata of Secondary Syphilis
Authors: Josip Begovac, Davorka Lukas
Journal: New England Journal of Medicine (2005)

A 34-year old bisexual man with newly diagnosed human immunodeficiency virus type 1 (HIV-1) infection presented with a one-month history of anal and oral lesions. He recalled having had a lesion on the foreskin of his penis three months previously; it had cleared spontaneously. Physical examination revealed the warty, mucoid, plaque-like perianal lesions of condylomata lata as well as “snail-track” ulcerations in the mouth and on the lips and tongue. Generalized lymphadenopathy was present, but the patient had no rash, constitutional symptoms, or headache. The CD4 cell count was 437 per cubic millimeter, and the plasma HIV-1 viral load was . . .
Painful incarcerated hernia following a rugby union lineout
Authors: R H Thomas, G O Thomas
Journal: British Journal of Sports Medicine (1999)

Discussion related to hernias in sport usually involves the diagnosis and treatment of chronic musculotendinous groin disruption. A case of acute trauma in an incarcerated inguinal hernia, occurring in a rugby union player during a lineout, is presented. The injury arose as a result of a change in the laws of the game.
Characteristics, risk factors, and mortality of cirrhotic patients hospitalized for hepatic encephalopathy with and without acute-on-chronic liver failure (ACLF)
Authors: Juan Cordoba, Meritxell Ventura-Cots, Macarena Simón-Talero, Àlex Amorós, Marco Pavesi, Hendrik Vilstrup, Paolo Angeli, Marco Domenicali, Pere Ginés, Mauro Bernardi, Vicente Arroyo
Journal: Journal of Hepatology (2013)
The Dichloroacetate Dilemma: Environmental Hazard versus Therapeutic Goldmine—Both or Neither?
Authors: Peter W. Stacpoole
Journal: Environmental Health Perspectives (2010)

BackgroundDichloroacetate (DCA) is known to environmental scientists as a by-product of water chlorination and as a metabolite of industrial solvents, including Superfund chemicals. In contrast, DCA is studied by clinical investigators for its therapeutic potential in several life-threatening conditions, including genetic mitochondrial diseases, pulmonary arterial hypertension, and cancer. Thus, DCA holds an almost unique position at the interface between environmental science and allopathic medicine.ObjectiveI critically reviewed laboratory and clinical pharmacological research on DCA to address questions about the current and future status of DCA in relation to human health.DiscussionRecent information on the clinical toxicogenetics of DCA is interpreted particularly in light of its use as an investigational drug. Adverse effects from chronic DCA exposure have been identified in several target organs in animals. However, in humans, toxicity has so far been limited to reversible effects on the nervous system and liver. DCA is primarily biotransformed to glyoxylate by the bifunctional enzyme glutathione transferase zeta1 and maleylacetoacetate isomerase (GSTz1/MAAI), which also catalyzes the penultimate step in the phenylalanine and tyrosine catabolic pathway. DCA is a suicide inhibitor of GSTz1/MAAI, which can result in delayed plasma clearance of DCA and the accumulation of potentially toxic tyrosine intermediates. Age and GSTz1/MAAI haplotype can markedly affect the toxicokinetics of DCA in humans and rodents.ConclusionsI have defined new potential avenues of research that focus on discrete human populations that may be at increased health risk or that may receive increased health benefit from chronic exposure to DCA at both environmentally and clinically relevant concentrations.
Delayed-type hypersensitivity reaction to paraphenylenediamine is mediated by 2 different pathways of antigen recognition by specific αβ+ human T-cell clones
Authors: Sonja Sieben, Yo Kawakubo, Tames Al Masaoudi, Hans F. Merk, Brunhilde Blömeke
Journal: Journal of Allergy and Clinical Immunology (2002)
Genotyping for polymorphisms in xenobiotic metabolism as a predictor of disease susceptibility.
Authors: A K Daly, S Cholerton, M Armstrong, J R Idle
Journal: Environmental Health Perspectives (1994)

Polymorphisms in many xenobiotic metabolizing enzymes occur leading to variation in the level of enzyme expression in vivo. Enzymes showing such polymorphisms include the cytochrome P450 enzymes CYP1A1, CYP1A2, CYP2A6, CYP2D6, and CYP2E1 and the phase two metabolism enzymes glutathione S-transferase MI (GSTMI) and arylamine N-acetyltransferase 2 (NAT2). In the past, these polymorphisms have been studied by phenotyping using in vivo administration of probe drugs. However, the mutations which give rise to several of these polymorphisms have now been identified and genotyping assays for polymorphisms in CYP1A1, CYP2A6, CYP2D6, CYP2E1, GSTMI, and NAT2 have been developed. Specific phenotypes for several of the polymorphic enzymes have been associated with increased susceptibility to malignancy, particularly lung and bladder cancer, and Parkinson's disease. These associations are likely to be due to altered activation or detoxication of chemicals initiating these diseases, including components of tobacco smoke and neurotoxins. The substrate specificity and tissue distribution of polymorphic enzymes implicated in disease causation discussed with particular reference to previously described disease-phenotype associations.
Electrocardiogram in Alcoholism and Accompanying Physical Disease
Authors: R. G. Priest, J. K. Binns, A. H. Kitchin
Journal: BMJ (1966)

The initial severity and extent of disease give a poor guide to the ultimate outcome of patients with ulcerative colitis, partly because the disease shows a tendency in many patients to extend proximally.Further analysis, however, shows that the severity and extent during each year profoundly influence the course and outcome during that year.Each patient-year in which a severe attack of colitis occurs carries a risk to life of 14%.Each patient-year in which there is total involvement of the colon and rectum carries a risk to life of 2.7%, and this risk is relatively unaffected by age or duration of colitic symptoms.It is argued that patients with total involvement should therefore be recommended to undergo elective proctocolectomy; for this form of treatment in the long run carries considerably less risk to life.We are grateful to Dr.
Protein kinase C activity and its subcellular distribution in the atria and ventricles of rats with cardiac hypertrophy
Authors: Sergio Lavandero, Eduardo Guarda, Gastón Cartagena, Rocio Foncea, Mario Sapag-Hagar, Jorge Jalil, Pablo Casanegra, Ramón Corbalán
Journal: Journal of the American College of Cardiology (1991)
Peritonitis Due to Histoplasmosis
Authors: PRATHAPCHANDRA A. REDDY
Journal: Annals of Internal Medicine (1970)

Histoplasmosis can produce disseminated lesions similar to those of tuberculosis. Peritonitis due to histoplasmosis may be important in the diagnosis of peritoneal disorders. The woman reported here had peritonitis as a result of hematogenous infection. This patient was erroneously diagnosed as having Hodgkin's disease and was treated with cyclophosphamide. Treatment with cyclophosphamide and corticoids probably contributed to the dissemination of the infection. Amphotericin B is presently the most effective agent for the treatment of histoplasmosis. Early institution of therapy may alter the grave prognosis of this form of the disease.
Ribosomal Protein L17, RpL17, is an Inhibitor of Vascular Smooth Muscle Growth and Carotid Intima Formation
Authors: Elaine M. Smolock, Vyacheslav A. Korshunov, Galina Glazko, Xing Qiu, Janice Gerloff, Bradford C. Berk
Journal: Circulation (2012)

Carotid intima-media thickening is associated with increased cardiovascular risk in humans. We discovered that intima formation and cell proliferation in response to carotid injury is greater in SJL/J (SJL) in comparison with C3HeB/FeJ (C3H/F) mice. The purpose of this study was to identify candidate genes contributing to intima formation.We performed microarray and bioinformatic analyses of carotid arteries from C3H/F and SJL mice. Kyoto Encyclopedia of Genes and Genomes analysis showed that the ribosome pathway was significantly up-regulated in C3H/F in comparison with SJL mice. Expression of a ribosomal protein, RpL17, was >40-fold higher in C3H/F carotids in comparison with SJL. Aortic vascular smooth muscle cells from C3H/F grew slower in comparison to SJL. To determine the role of RpL17 in vascular smooth muscle cell growth regulation, we analyzed the relationship between RpL17 expression and cell cycle progression. Cultured vascular smooth muscle cells from mice, rats, and humans showed that RpL17 expression inversely correlated with growth as shown by decreased cells in S phase and increased cells in G(0)/G(1). To prove that RpL17 acted as a growth inhibitor in vivo, we used pluronic gel delivery of RpL17 small interfering RNA to C3H/F carotid arteries. This resulted in an 8-fold increase in the number of proliferating cells. Furthermore, following partial carotid ligation in SJL mice, RpL17 expression in the intima and media decreased, but the number of proliferating cells increased.RpL17 acts as a vascular smooth muscle cell growth inhibitor (akin to a tumor suppressor) and represents a potential therapeutic target to limit carotid intima-media thickening.
Dermatoglyphics in Darier's disease
Authors: D. BLACKWELL, S. SHUSTER
Journal: British Journal of Dermatology (1997)

Palmar and fingerprints were taken from 70 patients with Darier's disease and 409 normal controls. The dermatoglyphic characteristics of each group were determined and comparisons were made between them. Dermatoglyphic abnormalities were found; some confirmed previous findings and some were novel, but they are too small in degree and frequency to be of use diagnostically.
A CD44v6 peptide reveals a role of CD44 in VEGFR-2 signaling and angiogenesis
Authors: Martina Tremmel, Alexandra Matzke, Imke Albrecht, Anna M. Laib, Vivienne Olaku, Kurt Ballmer-Hofer, Gerhard Christofori, Mélanie Héroult, Hellmut G. Augustin, Helmut Ponta, Véronique Orian-Rousseau
Journal: Blood (2009)
Hypertension and Angina Pectoris
Authors: Edward D. Frohlich
Journal: JAMA (1978)

MOST efforts concerned with preventive cardiology have emphasized the importance of the coexistence of hypertension with noninfarction coronary arterial disease in ambulatory patients in the United States. A recent report to the American College of Cardiology indicated that 95% of all patients seen by practicing cardiologists have hypertension or noninfarction coronary disease. More than 50% of all deaths in this country today may be related to cardiovascular disease, with hypertension and atherosclerotic coronary arterial disease accounting for the greatest number of these deaths by far. Persistently elevated arterial pressure itself predisposes to development of atherosclerosis.<sup>1</sup>Thus the greatest risk factor for most patients with cardiovascular diseases is an elevated arterial pressure; this risk factor certainly is the most amenable to therapeutic intervention today. The physician should review the major differential diagnostic possibilities that can produce chest pain, as well as those predisposing to chest pain of myocardial origin.<sup>2</sup>
Improvement in skin wrinkles from the use of photostable retinyl retinoate: a randomized controlled trial
Authors: H. Kim, N. Kim, S. Jung, J. Mun, J. Kim, B. Kim, J. Lee, H. Ryoo, H. Jung
Journal: British Journal of Dermatology (2009)

Journal Article Improvement in skin wrinkles from the use of photostable retinyl retinoate: a randomized controlled trial Get access H. Kim, H. Kim Department of Biotechnology, Yonsei University, 134 Shinchon‐dong, Seoul, 120‐749, KoreaDepartment of Skin Science and Cosmetics, ENPRANI Co. Ltd, Shinhung‐dong 3 Ga, Chung‐Gu, Inchon, 400–103, Korea Department of Biotechnology, Yonsei University, 134 Shinchon‐dong, Seodaemun‐Gu, Seoul, 120–749, Korea Search for other works by this author on: Oxford Academic Google Scholar N. Kim, N. Kim Department of Clinical Evaluation, Ellead Skin Evaluation Center, Seohyun‐dong, Seongnam‐si, Kyunggi‐do, 463‐824, Korea Search for other works by this author on: Oxford Academic Google Scholar S. Jung, S. Jung Department of Clinical Evaluation, Ellead Skin Evaluation Center, Seohyun‐dong, Seongnam‐si, Kyunggi‐do, 463‐824, Korea Search for other works by this author on: Oxford Academic Google Scholar J. Mun, J. Mun Department of Clinical Evaluation, Ellead Skin Evaluation Center, Seohyun‐dong, Seongnam‐si, Kyunggi‐do, 463‐824, Korea Search for other works by this author on: Oxford Academic Google Scholar J. Kim, J. Kim Department of Skin Science and Cosmetics, ENPRANI Co. Ltd, Shinhung‐dong 3 Ga, Chung‐Gu, Inchon, 400–103, Korea Department of Biotechnology, Yonsei University, 134 Shinchon‐dong, Seodaemun‐Gu, Seoul, 120–749, Korea Search for other works by this author on: Oxford Academic Google Scholar B. Kim, B. Kim Department of Skin Science and Cosmetics, ENPRANI Co. Ltd, Shinhung‐dong 3 Ga, Chung‐Gu, Inchon, 400–103, Korea Department of Biotechnology, Yonsei University, 134 Shinchon‐dong, Seodaemun‐Gu, Seoul, 120–749, Korea Search for other works by this author on: Oxford Academic Google Scholar J. Lee, J. Lee Department of Skin Science and Cosmetics, ENPRANI Co. Ltd, Shinhung‐dong 3 Ga, Chung‐Gu, Inchon, 400–103, Korea Department of Biotechnology, Yonsei University, 134 Shinchon‐dong, Seodaemun‐Gu, Seoul, 120–749, Korea Search for other works by this author on: Oxford Academic Google Scholar H. Ryoo, H. Ryoo Department of Skin Science and Cosmetics, ENPRANI Co. Ltd, Shinhung‐dong 3 Ga, Chung‐Gu, Inchon, 400–103, Korea Department of Biotechnology, Yonsei University, 134 Shinchon‐dong, Seodaemun‐Gu, Seoul, 120–749, Korea Search for other works by this author on: Oxford Academic Google Scholar H. Jung H. Jung Department of Biotechnology, Yonsei University, 134 Shinchon‐dong, Seoul, 120‐749, Korea Hyungil Jung. E‐mail: hijung@yonsei.ac.kr Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 162, Issue 3, 1 March 2010, Pages 497–502, https://doi.org/10.1111/j.1365-2133.2009.09483.x Published: 01 March 2010
BURN OF EYES FROM CONTENTS OF GOLF-BALL CORE
Authors: Holbrook Lowell
Journal: JAMA (1913)

During the last few years cases of severe, permanent injury due to corneal and conjunctival burns have been reported from all over the country. The burns referred to have been caused by the liquid contained in the small rubber core of certain golf-balls, which have been cut open by curious children. Almost invariably the history is that some child finds an old golf-ball with its covering partly off. He removes the rest of the cover and rubber and then comes to the core ball; this he bounces until it bursts, or punctures it with a knife. The contained fluid spurts out onto his clothing and into his eyes.  There are apparently two makes of golf-balls on the market, each containing a different, highly caustic substance. Dr. R. L. Emerson of Boston very kindly analyzed the semifluid mass contained in one of the golf-balls, said to be of similar make to
Access to Kidney Transplantation Among Remote- and Rural-Dwelling Patients With Kidney Failure in the United States
Authors: Marcello Tonelli
Journal: JAMA (2009)

US residents with end-stage renal disease (ESRD) may live far away from the closest transplant center, which could compromise their access to kidney transplantation.To assess access to kidney transplantation as a function of distance from the closest transplant center or as a function of rural rather than urban residence.Observational study of 699,751 adult patients with kidney failure who had initiated renal replacement in the United States between 1995 and 2007 and were thus placed on a prospective mandatory registry list.Time to placement on the kidney transplant waiting list and time to kidney transplantation, both measured at the start of renal replacement.During a median follow-up of 2.0 years (range, 0.0-12.5 years), 122,785 (17.5%) patients received a kidney transplant. Median distance to the closest transplant center was 15 miles. Participants were classified into distance categories by miles from a transplant center with 0 to 15 miles serving as the referent category. Compared with the referent category, the adjusted hazard ratios of deceased or living donor transplantation within each category follows: 16 to 50 miles, 1.03 (95% CI, 1.02-1.05); 51 to 100 miles, 1.11 (95% CI, 1.09-1.12); 101 to 136 miles, 1.14 (95% CI, 1.11-1.17); 137 to 231 miles, 1.16 (95% CI, 1.13-1.20); 232 to 310 miles, 1.20 (95% CI, 1.12-1.28); and more than 310 miles, 1.16 (95% CI, 1.09-1.23). When residence location was classified using rural-urban commuter areas, 79.6% of patients lived in urban; 10.3%, micropolitan; and 10.0%, rural areas. Compared with those living in metropolitan areas, the adjusted hazard ratios of deceased or living donor transplantation among patients residing in micropolitan communities was 1.13 (95% CI, 1.11-1.15) and 1.15 (95% CI, 1.13-1.18) for rural areas. Results were similar for both deceased donor and living donor transplantation and were consistent in multiple sensitivity analyses.Remote or rural residence was not associated with increased time to kidney transplantation among people treated for ESRD in the United States.
IMPOSSIBILITY OF MOVING VERTEBRAE
Authors: L. C. Kellogg
Journal: JAMA (1923)

<h3>To the Editor:</h3> —In these days, when we hear on every side the claims that the articulations of the spinal column need repeated "adjustments," I think that medical men ought to have some definite data as to the strength of the spinal symphyses. The following experiments were performed in the anatomy laboratory of the College of Medical Evangelists at Loma Linda, Calif.: The spinal column selected was a fairly fresh one, and it was taken from a cadaver that had never been put into the preserving tank. A block of wood was taken, and into its surface there was cut a mortise slightly wider than the vertical dimension of a lumbar vertebra. The spinal column was then firmly fastened to this block so that the ventral margin was against the surface of the wood, and the body of the second lumbar vertebra was directly over the mortise, thus leaving that
The ATPases of Muscle Proteins
Authors: John V. Taggart, MANUEL F. MORALES, SHIZUO WATANABE
Journal: Circulation (1961)

The ideas and results of Blum, Oosawa, Strohman, and many others are reviewed and, when consolidated with the authors' work, lead to the following picture of muscle protein adenosine triphosphatases (ATPases). Two major features of myocin ATPase seem to be a catalytic interaction between enzyme, a metal cation, and the terminal pyrophosphate moiety of adenosine triphosphate (ATP) and a rate-retarding interaction between enzyme, Mg ++ , and the purine ring of ATP. Sulfhydryl groups of the enzyme participate at both loci. In the catalytic interaction an ionizable group (pK, ca. 6.8) may participate. G-actin molecules binding ATP (probably by the purine ring) and relieved of their mutual repulsion cooperate in catalysing dephosphorylation, thereby giving rise to the somewhat loose, possibly helical, structure of F-actin.
Clinical Experience with the N-shaped Ileal Neobladder: Assessment of Complications, Voiding Patterns, and Quality of Life in Our Series of 58 Patients
Authors: S. Joniau, J. Benijts, M. Van Kampen, M. De Waele, J. Ooms, B. Van Cleynenbreugel, H. Van Poppel
Journal: European Urology (2005)
Anaphylactic and Anaphylactoid Reactions Associated With Lepirudin in Patients With Heparin-Induced Thrombocytopenia
Authors: A. Greinacher, N. Lubenow, P. Eichler
Journal: Circulation (2003)

Lepirudin (Refludan) is a hirudin derivative. It is a direct thrombin inhibitor obtained by recombinant technology from the medicinal leech and is approved for treatment of heparin-induced thrombocytopenia complicated by thrombosis. Because 3 cases of fatal anaphylaxis possibly associated with use of lepirudin have been reported, we initiated an investigation of putative lepirudin-associated anaphylaxis.Aided by the manufacturer (Schering AG, Berlin, Germany), we used the lepirudin study databases to identify all patients in whom possible anaphylaxis/severe allergy was recorded from 1994 to September 2002. The 26 possible cases identified were reviewed independently by 2 investigators. After excluding patients with mild skin reactions, reactions likely caused by concomitant medications, poorly documented cases, and reactions that did not correspond temporally with lepirudin use, there remained 9 patients judged to have had severe anaphylaxis in close temporal association with lepirudin. All reactions occurred within minutes of intravenous lepirudin administration, with 4 fatal outcomes (3 acute cardiorespiratory arrests, 1 hypotension-induced myocardial infarction). In these 4 cases, a previous uneventful treatment course with lepirudin was identified (1 to 12 weeks earlier). We recorded high-titer IgG-anti-lepirudin antibodies in an additional patient with anaphylaxis. Because lepirudin has been used in approximately 35 000 patients, the risk of anaphylaxis is approximately 0.015% (5 of 32 500) on first exposure and 0.16% (4 of 2500) in reexposed patients (7.5% estimated reexposures).Lepirudin can cause fatal anaphylaxis, particularly in patients who are treated within 3 months of a previous exposure. The overall risk/benefit assessment of lepirudin as a treatment for heparin-induced thrombocytopenia remains favorable.