Cocaine-Induced Acute Cytologic Hepatitis in HIV-Infected Patients with Nonactive Viral Hepatitis
Authors: Hélène Peyrière, Jean-Marc Mauboussin, Pierre Balmes
Journal: Annals of Internal Medicine (2000)

Letters20 June 2000Cocaine-Induced Acute Cytologic Hepatitis in HIV-Infected Patients with Nonactive Viral HepatitisHélène Peyrière, PharmD, PhD, Jean-Marc Mauboussin, MD, and Pierre Balmes, MDHélène Peyrière, PharmD, PhDSaint-Charles Hospital; 34295 Montpellier, France (Peyrière)Gaston Doumergue Hospital; 30000 Nîmes, France (Mauboussin)Gaston Doumergue Hospital; 30000 Nîmes, France (Balmes), Jean-Marc Mauboussin, MDSaint-Charles Hospital; 34295 Montpellier, France (Peyrière)Gaston Doumergue Hospital; 30000 Nîmes, France (Mauboussin)Gaston Doumergue Hospital; 30000 Nîmes, France (Balmes), and Pierre Balmes, MDSaint-Charles Hospital; 34295 Montpellier, France (Peyrière)Gaston Doumergue Hospital; 30000 Nîmes, France (Mauboussin)Gaston Doumergue Hospital; 30000 Nîmes, France (Balmes)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-12-200006200-00035 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Cocaine hepatotoxicity is well documented, but there are few data on effects of nonparenteral cocaine use (1-3). We report intranasal cocaine–induced acute hepatitis in three HIV-infected patients with viral hepatitis.The patients were seropositive for hepatitis B virus (patient 1) and hepatitis C virus (patients 2 and 3) and had no signs of liver dysfunction. Acute cytolytic hepatitis occurred a few days after intranasal intake of cocaine. In patients 2 and 3, hepatitis was associated with hepatomegaly, fever, stiffness, and sweat. The Table summarizes the findings on laboratory tests. Liver biopsy was not done in any patient. ...References1. Silva MO, Roth D, Rajender Reddy K, Fernandez JA, Albores-Saavedra J, Schiff ER. Hepatic dysfunction accompanying acute cocaine intoxication. J Hepatol. 1991;12:312-5. CrossrefMedlineGoogle Scholar2. Mallat A, Dhumeaux D. Cocaine and liver. J Hepatol. 1991;12:275-8. CrossrefMedlineGoogle Scholar3. Tabasco-Minguillan J, Novick DM, Kreek MJ. Liver function tests in non-parenteral cocaine users. Drug Alcohol Depend. 1990;26:169-74. CrossrefMedlineGoogle Scholar4. Wanless JR, Dore S, Gopinath N, Tan J, Cameron R, Heathcote EJ, et al . Histopathology of cocaine hepatotoxicity. Report of four patients. Gastroenterology. 1990;98:497-501. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Saint-Charles Hospital; 34295 Montpellier, France (Peyrière)Gaston Doumergue Hospital; 30000 Nîmes, France (Mauboussin)Gaston Doumergue Hospital; 30000 Nîmes, France (Balmes) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCocaine-induced acute hepatitis: A diagnosis not to forgetCocaineDrug-Induced Liver DiseaseDrugs of abuse: management of intoxication and antidotesDRUGS OF ABUSEHepatotoxicidad inducida por cocaínaElevations in Creatine Kinase and Hepatic Transaminases in an HIV-Positive PatientCocaineDrugs of abuse 20 June 2000Volume 132, Issue 12Page: 1010-1011KeywordsAminotransferasesCocaineHIV infectionsHepatitisHepatitis ALiverRhabdomyolysisStiffnessSweatToxicology Issue Published: 20 June 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...