Amoxapine Overdose: Report of Two Patients with Severe Neurologic Damage
Authors: MARK J. GOLDBERG
Journal: Annals of Internal Medicine (1982)

Brief Reports1 April 1982Amoxapine Overdose: Report of Two Patients with Severe Neurologic DamageMARK J. GOLDBERG, M.D., REYNOLD SPECTOR, M.D.MARK J. GOLDBERG, M.D.Search for more papers by this author, REYNOLD SPECTOR, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-96-4-463 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAmoxapine (Asendin, Lederle Laboratories, Pearl River, New York), a tricyclic dibenzoxazepine antidepressant, has been recently marketed in the United States. Development of new tricyclic antidepressants has continued in part because of the severe cardiovascular and central nervous system toxicity associated with overdoses of previous tricyclic antidepressants (1). We report two cases in which overdoses of amoxapine resulted in irreversible central nervous system damage.A 24-year-old healthy woman took approximately 4 g of amoxapine. She then slept for 4 hours before she was taken to the University of Iowa Hospitals on 12 May 1981. Initially, she was alert; she complained of...References1. BLACKWELI. B Adverse effects of antidepressant drugs. Part 2: 'Second generation' antidepressants and rational decision making in antidepressant therapy. Drugs. 1981;21:273-82. CrossrefMedlineGoogle Scholar2. REYNOLDSSOMHERRMANN PCP. Loxapine fatalities. Clin Toxicol. 1979;14:181-5. CrossrefMedlineGoogle Scholar3. TAMOLINRUIZ CBA. Loxapine-associated rhabdomyolysis and acute renal failure. Arch Intern Med. 1980;140:975-6. CrossrefMedlineGoogle Scholar4. DUKES M, ed. Meyler's Side Effects of Drugs. 9th ed. New York: Elsevier/North Holland Inc. ; 1980. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MARK J. GOLDBERG, M.D.; REYNOLD SPECTOR, M.D.Affiliations: University of Iowa College of Medicine; Iowa City, Iowa. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byアモキサピン中毒による痙攣重積発作により重篤なアシドーシス（pH 6.499）を呈するも，救命できた1症例(A survival case of amoxapine overdose presented severe acidosis (pH 6.499) due to status epilepticus)Simultaneous determination of 5 psychotropic drugs of various types in an autopsy case of acute multiple drug poisoningLimitation of Heat ToleranceAmoxapine Overdose: Recovery after Severe Metabolic Acidosis (pH 6.69) and Status EpilepticusSAFETY OF AMOXAPINEApparent Amoxapine Nephrotoxicity: Dependence on Rhabdomyolysis and AcidosisAmoxapine cardiotoxicityLoss of brainstem and pupillary reflexes in amoxapine overdose: A case reportThe newer antidepressants: Promises and realitiesSeizures with neuroleptics and antidepressantsClinical Features and Management of Self-Poisoning with Newer AntidepressantsManagement of poisoning associated with “newer” antidepressant agentsSeizures as a Manifestation of Systemic DiseaseRelative toxicity of cyclic antidepressantsElectrophysiological effects of amoxapine in untreated and in amoxapine-pretreated rat atriaReferencesSecond Generation Antidepressants: A Comparative ReviewEnvironmental and Drug-Induced Hyperthermia Pathophysiology, Recognition, ManagementAntidepressants: A Clinical Update for Medical PractitionersGeneralized Convulsions as the Presenting Sign of Amoxapine IntoxicationAntidepressant drugsLettersAmoxapine and Neurologic DeficitsKEN KULIG, M.D., BARRY H. RUMACK, M.D., JOHN A. MARX, M.D.Amoxapine Neurotoxicity: A Case Report with Long-Term Follow-up 1 April 1982Volume 96, Issue 4Page: 463-464KeywordsCentral nervous systemHospital medicineRiversToxicityTricyclic antidepressants ePublished: 1 December 2008 Issue Published: 1 April 1982 PDF downloadLoading ...