Newer Approaches to Ulcerative Colitis
Authors: SUMNER C. KRAFT
Journal: Annals of Internal Medicine (1967)

Editorial Notes1 December 1967Newer Approaches to Ulcerative ColitisSUMNER C. KRAFT, M.D., F.A.C.P.SUMNER C. KRAFT, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-6-1344 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMany theories have been proposed to explain nonspecific ulcerative colitis, but the etiology and pathogenesis of this disease remain unknown. The possible involvement of immune mechanisms has received special attention in the past decade on the basis of largely presumptive evidence from clinical and laboratory studies (1).Earlier investigations of ulcerative colitis from the immunologic point of view described a variety of circulating reactants in a relatively small percentage of patients with ulcerative colitis. However, antibodies to any antigen do not necessarily indicate an immunologically induced disease state (2), and it has not been possible to correlate clinical status with...References1. KRAFTKIRSNER SCJB: Present status of immunological mechanisms in ulcerative colitis. Gastroenterology 51: 788, 1966. CrossrefMedlineGoogle Scholar2. FARR RS: Some comments regarding the allergic state. The initiation of antibody synthesis. Arch. Environ. Health (Chicago) 6: 92, 1963. CrossrefMedlineGoogle Scholar3. LAGERCRANTZHAMMARSTRÖMPERLMANNGUSTAFSSON RSPBE: Immunological studies in ulcerative colitis. III. Incidence of antibodies to colon-antigen in ulcerative colitis and other gastro-intestinal diseases. Clin. Exp. Immun. 1: 263, 1966. MedlineGoogle Scholar4. MCGIVENDATTANAIRN ARSPRC: Human serum antibodies against rat colon mucosa. Nature (London) 214: 288, 1967. CrossrefMedlineGoogle Scholar5. KLEISTBURTIN SVP: On the specificity of autoantibodies present in colon cancer patients. Immunology 10: 507, 1966. MedlineGoogle Scholar6. THOMAS L: Circulating autoantibodies and human disease. With a note on primary atypical pneumonia. New Eng. J. Med. 270: 1157, 1964. CrossrefMedlineGoogle Scholar7. HESSFINKTARANTAZIFF EVCWAM: Heart muscle antibodies in rheumatic fever and other diseases. J. Clin. Invest. 43: 886, 1964. CrossrefMedlineGoogle Scholar8. PERLMANNHAMMARSTRÖMLAGERCRANTZGUSTAFSSON PSRBE: Antigen from colon of germfree rats and antibodies in human ulcerative colitis. Ann. N. Y. Acad. Sci. 124: 377, 1965. CrossrefMedlineGoogle Scholar9. ASHERSONHOLBOROW GLEJ: Autoantibody production in rabbits. VII. Autoantibodies to gut produced by the injection of bacteria. Immunology 10: 161, 1966. MedlineGoogle Scholar10. KAPLANSUCHY MHML: Immunologic relation of streptococcal and tissue antigens. II. Cross-reaction of antisera to mammalian heart tissue with a cell wall constituent of certain strains of group A streptococci. J. Exp. Med. 119: 643, 1964. CrossrefMedlineGoogle Scholar11. GOLDSTEINHALPERNROBERT IBL: Immunological relationship between streptococcus A polysaccharide and the structural glycoproteins of heart valve. Nature (London) 213: 44, 1967. CrossrefGoogle Scholar12. PERLMANNBROBERGER PO: In vitro studies of ulcerative colitis. II. Cytotoxic action of white blood cells from patients on human fetal colon cells. J. Exp. Med. 117: 717, 1963. CrossrefMedlineGoogle Scholar13. WATSONQUIGLEYBOLT DWARJ: Effect of lymphocytes from patients with ulcerative colitis on human adult colon epithelial cells. Gastroenterology 51: 985, 1966. CrossrefMedlineGoogle Scholar14. HINZPERLMANNHAMMARSTRÖM CFPS: Reactivity in vitro of lymphocytes from patients with ulcerative colitis. J. Lab. Clin. Med. 70: 752, 1967. MedlineGoogle Scholar15. STEFANIFINK SS: Effect of E. coli antigens, tuberculin, and phytohaemagglutinin upon ulcerative colitis lymphocytes. Gut 8: 249, 1967. CrossrefMedlineGoogle Scholar16. WATSONSTYLERBOLT DWHJRJ: The autologous leukocyte skin test in patients with ulcerative colitis. Gastroenterology 49: 649, 1965. CrossrefMedlineGoogle Scholar17. FINKDONNELLYJABLOKOW SWJVR: Rectal reaction to injected ulcerative colitis leucocytes and plasma. Gut 8: 20, 1967. CrossrefMedlineGoogle Scholar18. BOWENIRONSRHODESKIRSNER GEGVJBJB: Early experiences with azathioprine in ulcerative colitis; a note of caution. JAMA 195: 460, 1966. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine University of Chicago School of Medicine Chicago, Ill. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByUlcerative colitis, autoimmune epiphenomena, and colonic cancerClinical Observations on Inflammatory Bowel Disease 1 December 1967Volume 67, Issue 6Page: 1344-1346KeywordsAntibodiesAntigensClinical laboratoriesEtiologyPathogenesisResearch laboratoriesUlcerative colitis Issue Published: 1 December 1967 PDF DownloadLoading ...