tbuckley/cabot-search huggingface dataset:
Recovery from Aplastic Anemia after Non-A, Non-B Posttransfusion Hepatitis
Authors: Mariano Linares
Journal: Annals of Internal Medicine (1988)

Letters and Corrections15 September 1988Recovery from Aplastic Anemia after Non-A, Non-B Posttransfusion HepatitisMariano Linares, Isidro Jarque, Pedro Pallares, Teresa TusetMariano LinaresSearch for more papers by this author, Isidro JarqueSearch for more papers by this author, Pedro PallaresSearch for more papers by this author, Teresa TusetSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-6-513 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: Improvement of several hematologic disorders after viral hepatitis has been reported. In two studies the duration of remission and survival were superior for patients with acute nonlymphocytic leukemia who developed hepatitis when compared with those without hepatitis (1, 2). Two patients with the myelodysplastic syndrome had improved erythrocyte production and lost their chronic transfusion requirement when they developed non-A, non-B hepatitis (3). Complete peripheral blood remission has been reported in patients with hairy cell leukemia after hepatitis (4, 5).A 69-year-old man was seen in June 1987 because of anemia. He had a 2-year history of trigeminal...References1. BartonConrad JM. Beneficial effects of hepatitis in patients with acute myelogenous leukemia. Ann Intern Med. 1979;90:188-90. LinkGoogle Scholar2. FoonYaleClodfelterGale KCKR. Posttransfusion hepatitis in acute myelogenous leukemia, effect on survival. JAMA. 1980;244:1806-7. CrossrefMedlineGoogle Scholar3. AbkowitzPowellNakamuraKadinAdamson JJJMJ. Pure red cell aplasia: response to therapy with anti-thimocyte globulin. Am J Hematol. 1986;23:363-71. CrossrefMedlineGoogle Scholar4. BrodyRussellKrantzGraber SWSS. Beneficial effects of hepatitis in leukemia reticuloendotheliosis. Arch Intern Med. 1981;141:1080-1. CrossrefMedlineGoogle Scholar5. KeeferWeberBottomleySolankiHosty MMSDT. Peripheral blood remission of hairy cell leukemia after transfusion hepatitis. Am J Med. 1987;25:277-84. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Hospital Lluis Alcanyis, 46800 Xativa (Valencia) Spain PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 September 1988Volume 109, Issue 6Page: 513-514KeywordsAcute myeloid leukemiaAnemiaAplastic anemiaBlood cellsHepatitisMyelodysplastic syndromes Issue Published: 15 September 1988 PDF DownloadLoading ...
Norepinephrine Induces the <i>raf</i> -1 Kinase/Mitogen-Activated Protein Kinase Cascade Through Both α <sub>1</sub> - and β-Adrenoceptors
Authors: Tsutomu Yamazaki, Issei Komuro, Yunzeng Zou, Sumiyo Kudoh, Ichiro Shiojima, Yukio Hiroi, Takehiko Mizuno, Ryuichi Aikawa, Hiroyuki Takano, Yoshio Yazaki
Journal: Circulation (1997)

Background Although norepinephrine induces cardiac hypertrophy by activating protein kinase A and C through β- and α 1 -adrenoceptors, respectively, protein kinase A has been reported to inhibit cell growth in many other cell types. Methods and Results To elucidate the molecular mechanism of norepinephrine-induced hypertrophic responses, we examined the effects of protein kinase A and protein kinase C on the activities of raf -1 kinase and mitogen-activated protein (MAP) kinases and on protein synthesis rates using cultured cardiomyocytes of neonatal rats. Norepinephrine-induced activation of MAP kinases was partially inhibited by either an α 1 -adrenoceptor blocker (prazosin) or a β-adrenoceptor blocker (propranolol) and was completely abolished by both blockers. Both a β-adrenoceptor agonist, isoproterenol, and an α 1 -adrenoceptor agonist, phenylephrine, increased the activities of raf -1 kinase and MAP kinases and phenylalanine incorporation into proteins. Furthermore, isoproterenol and phenylephrine synergistically activated these kinases and protein synthesis. Similar synergistic activation of MAP kinases was observed when other protein kinase A–activating agents such as forskolin, dibutyryl cAMP, and isobutylmethylxanthine were used with a protein kinase C–activating agent at the same time. Chelation of extracellular Ca 2+ completely abolished isoproterenol- and phenylephrine-evoked MAP kinase activation. Conclusions Norepinephrine activates the raf -1 kinase/MAP kinase cascade through both α 1 - and β-adrenergic stimulation, and signaling pathways from the two receptors synergistically induce cardiomyocyte hypertrophy.
Diminished Baroreflex Sensitivity in High Blood Pressure
Authors: J. DAVID BRISTOW, A. JOHN HONOUR, GEORGE W. PICKERING, PETER SLEIGHT, HARLEY S. SMYTH
Journal: Circulation (1969)

Sudden intravenous injections of small amounts of angiotensin or phenylephrine were given to 30 subjects to produce modest, brief increases in directly measured systemic arterial pressure. A plot of each systolic pressure against the second succeeding cardiac cycle length produced a linear distribution, the slope of which was expressed as the millisecond increase in cycle length per mm Hg rise in systolic pressure. The slope is an index of baroreflex sensitivity and was found to have an average value of 12.8 in 18 subjects without hypertension and 2.8 in 12 others with hypertension. When all results were pooled, there was an inverse relationship between the resting mean arterial pressure and slope of the baroreflex regression lines. The findings demonstrate reduced sensitivity of the baroreflexes in hypertension, with respect to control of heart rate. A distinction is made between this change in sensitivity and simple resetting of the reflex.
Salmonella infection in hairy cell leukemia: Report of a case
Authors: Hervé Tilly, Martine Gardembas, Michel Berry, Christian Gray, Mathieu Monconduit, Hubert Piguet
Journal: American Journal of Hematology (1985)

Abstract A patient with hairy cell leukemia who developed mediastinal mass and fever is described. A CT‐guided aspiration of the mass yielded Salmonella tiphymurium. Granulocyte response to infection was intact and could explain the favorable course of this unusual Salmonella infection. Although several reports deal with salmonellosis as a complication of immunodeficiency states, this type of infection is of rare occurence in hairy cell leukemia.
Bortezomib Plus Docetaxel in Advanced Non-small Cell Lung Cancer and Other Solid Tumors: A Phase I California Cancer Consortium Trial
Authors: Primo N. Lara, Mariana Koczywas, David I. Quinn, Heinz Josef Lenz, Angela M. Davies, Derick H.M. Lau, Paul H. Gumerlock, Jeff Longmate, James H. Doroshow, David Schenkein, Oscar Kashala, David R. Gandara
Journal: Journal of Thoracic Oncology (2006)
Skin Markings in Malignant Melanoma
Authors: Edward E. Bondi
Journal: JAMA (1983)

Photographic analysis of the skin markings in 92 malignant melanomas (66 superficial spreading, seven nodular, 12 acral lentiginous, and seven lentigo maligna melanomas) was undertaken. Skin markings are uniformly eradicated in areas of vertical growth phase disease and sometimes in areas of regression. Not only were skin markings always preserved in areas of radical growth phase disease, but they were sometimes accentuated. For all types of melanoma, loss of skin markings is a poor diagnostic criterion because it is a late sign associated with invasion of the dermis and thus a deteriorating prognosis.
A CASE OF MYOCLONIC ENCEPHALITIS LETHARGICA SIMULATING HYDROPHOBIA
Authors: S. E. Denyer, D. E. Morley
Journal: BMJ (1921)

THEI following case of fracture of the first rib is interesting, both on account of its rarity and its clinical similarity to a cervical rib or exostosis.A female, aged 17 years, complainied of a swelling in the right side of the neck.The patienit was unaware of its presence until it was noticed first by another girl.She had had " pins and needles " in the right hand anid cramp in the arm for some time, and attributed this to an accident two months earlier, when she fell down a few stairs.She did not remember her
Prevalence of Regurgitant Murmurs in Patients with Valvular Regurgitation Detected by Doppler Echocardiography
Authors: Peter S. Rahko
Journal: Annals of Internal Medicine (1989)

To determine the relation between heart valve regurgitation detected by Doppler echocardiography and audible regurgitant murmurs.Consecutive sample.Adult echocardiography laboratory in a tertiary care university hospital.Sequential sample of 408 patients presenting for clinical echocardiographic studies who had technically satisfactory studies and were available for auscultation.Valvular regurgitation occurred in 43% of patients at the mitral valve, 39% of patients at the tricuspid valve, 33% of patients at the aortic valve, and 15% of patients at the pulmonic valve. Corresponding regurgitant murmurs were frequently absent. A murmur corresponding to Doppler-detected regurgitation was detected in 56% of patients with mitral regurgitation, 61% of patients with aortic regurgitation, 28% of patients with tricuspid regurgitation, and 15% of patients with pulmonic regurgitation. There was a highly significant positive correlation of audibility with severity of valve regurgitation for the aortic, tricuspid, and mitral valves. Audibility ranged from 10% to 40% for mild regurgitation to 86% to 100% for severe regurgitation. Murmur audibility was not related to the type of valvular disease present.Doppler echocardiography is a sensitive method for detecting valve regurgitation. Corresponding regurgitant murmurs are frequently not present. The audibility of regurgitant murmur is highly dependent on the severity of valve regurgitant and has little relation to the type of valve disease present.
Designer drinks and drunkenness amongst a sample of Scottish schoolchildren
Authors: N. McKeganey, A. Forsyth, M. Barnard, G. Hay
Journal: BMJ (1996)

There has been growing concern within the media and elsewhere over the recent development of alcoholic drinks which in aspects of their marketing, and in some cases their sweet taste, may particularly appeal to young people. These drinks include such white ciders as Ice Dragon, TNT, White Lightening, and Spectra White (many of which contain about 8% alcohol by volume), as well as such fruit wines as Maddog 20/20, Flavours for Ravers, and Fruits Unlimited (many of which contain about 13% alcohol by volume). We provide information on the consumption of these drinks in a representative sample of schoolchildren in Dundee, Scotland. These data were collected as part of an ongoing survey of young people's routes into illicit drug use.1

In November 1994, a 1 in 10 sample of all comprehensive school children in compulsory school years S1 to S4 (age 12 to 15) in Dundee was surveyed (n = 758). The five schools participating …
Abstract 5453: The effect of ovarian hormones on the induction of mammary tumors induced by the environmental pollutant 6-nitrochrysene
Authors: Yuan-Wan Sun, Jacek Krzeminski, Ceser Aliaga, Andrea Manni, Shantu Amin, Karam El-Bayoumy
Journal: Cancer Research (2012)

Abstract Exposure to ovarian hormones is the most widely recognized risk factors for breast cancer. However, hormones alone do not fully address the majority of the risk for this disease. Increasing data have linked environmental factors such as radiation, chemical pollutants and diet to the incidence of breast cancer. Humans are often exposed to a combination of multiple risk factors. Thus, the potential of the interaction between the environment and hormones is critical to assess the risk of breast cancer. The goal of the present study is to examine the role of ovarian hormones on the induction of mammary tumors by 6-nitrochrysene (6-NC), a representative environmental pollutant. We have previously demonstrated that 6-NC is one of the most potent mammary carcinogen in the rat. Thus, 6-NC (25 µmol in 500 µL trioctanoin) was administered orally to both female intact and ovariectomized (ovax) Sprague-Dawley rats at age of 30 days once a week for 8 weeks. Tumors in the intact animals was first detected at week 4 (incidence 8%) and tumor incidence reached 50% at week 18 after the last administration of 6-NC. On the contrary, in the group of ovax rats tumors were first observed at week 8 (4% incidence) and the incidence remained the same at week 22 after the last dose of 6-NC administration. Further evidence to support this hormone dependence is also observed in a separate group of ovax rats which received both 6-NC at the same dose described above and estradiol (E2) pellet implantation (twice, 5 mg/90 days); mammary tumor incidence was comparable to that observed in intact animals treated with 6-NC. No tumors were found in vehicle (trioctanoin) treated intact and ovax control groups. In this study, we showed for the first time that ovarian hormones are essential in the development of mammary tumors induced by this environmental pollutant; the molecular mechanisms are being explored. Support: NCI RO1 35519. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5453. doi:1538-7445.AM2012-5453
P365Protection against doxorubicine-induced cardiomyopathy by bergamot polyphenols through myocyte survival and cardiac stem cell activation
Authors: C Carresi, I Aquila, F Marino, V Musolino, C Correale, M Gliozzi, GM Ellison, B Nadal-Ginard, D Torella, V Mollace
Journal: Cardiovascular Research (2014)

Purpose: The clinical use of Doxorubicin (DOX) has the serious drawback of cardiotoxicity, which over time causes a cardiomyopathy leading to heart failure. The molecular pathogenesis of anthracycline cardiotoxicity remains highly controversial. Recently, it has been suggested that resident endogenous cardiac stem/progenitor cell (eCSC) depletion contributes to DOX-induced cardiomyopathy. Dietary polyphenols play a beneficial cardiovascular protecting role due to their pleiotropic anti-oxidative/inflammatory effects. Thus, we have investigated whether a mixture of flavonoids extracted from Bergamot (Citrus Bergamia, an endemic plant from Southern Italy), the bergamot-derived polyphenolic fraction (BPF), could attenuate myocyte damage and improve myocyte regeneration through eCSC activation in DOX-induced cardiomyopathy. Methods: We first assessed BPF's effects on DOX-induced damage in CSCs in vitro. For in vivo studies, Wistar male rats (n=36) were randomly assigned to receive intra-peritoneal injection of saline (that served as controls, CTRL, n=6), BPF (20mg/kg daily, n=10), DOX (6 doses of 2,5mg/Kg from day 1 to day 14, n=10), and DOX+BPF (n=10). To track new cardiac cell formation all animals were implanted with subcutaneous micro-pumps to systemically release BrdU over 21 days when the rats were sacrificed. Results: BPF significantly reduces reactive oxygen species (ROS) accumulation and apoptotic death in CSCs in vitro. Intriguingly, BPF enhanced CSC specification into beating cardiomyocytes in vitro. Importantly, BPF in vivo treatment was able to prevent DOX-induced LV impairment. Echocardiography imaging demonstrated that DOX+BPF group had a significantly improved ejection fraction, fractional shortening and myocardial strain when compared to DOX-treated rats. DOX caused significant myocyte apoptosis with reactive myocyte hypertrophy when compared to CTRL. c-kit+ eCSC number was not significantly higher in DOX compared to CTRL. Only rare BrdU labelled cardiac cell nuclei but no BrdU+ myocytes were identified in DOX-induced cardiomyopathy, showing a lack of myocardial regeneration. On the contrary, BPF significantly reduced myocyte loss and myocyte hypertrophy by DOX. This improvement was associated with an increased number of activated BrdU+ eCSCs and differentiating newly-formed BrdU+ cardiomyocytes. Conclusions: BPF reduces DOX-induced cardiotoxicity decreasing myocyte loss and enhancing CSC activation and cardiomyocyte replacement. These data suggest that a BPF-supplemented diet could have beneficial effects in attenuating cardiotoxicity in patients requiring anthracycline chemiotherapy.
Can there be embodiment without a body/brain?
Authors: Denis Mareschal
Journal: Behavioral and Brain Sciences (2001)

A mature science strives to provide causal explanations of observed phenomena rather than focusing on taxonomic descriptions of data. A field theory model is a step towards providing a truly scientific account of development. However, the model is under-constrained in that it ignores the boundary conditions defined by the physical constraints imposed by the infant's developing brain and body.
Junior Review Selection
Authors: I. Agache
Journal: Allergy (2002)

Dear Readers, On behalf of Junior Members & Affiliates I am pleased to introduce a new series of review articles to be published in every second issue of Allergy. Articles in this series will cover all areas of interest suggested by the JMAs, from bench to bedside. The JMAs can also select the speakers which will be invited on their behalf. The final goal of this series, besides continuous up-dating and revising the information in the field of allergy, is to spotlight unsolved or unanswered issues and thus to stimulate further research. The first article to be published in this series belongs to basic immunology. C.B. Schmidt-Weber and K. Blaser (1) offer an excellent review on T cell tolerance in allergic response as a future strategy to control allergic diseases. As previously demonstrated by Tsitoura, Blumenthal et al. CD4+ T cell unresponsiveness critically regulates immune responses to aeroallergens and protects against the development of allergic diseases and asthma, while Th1 biased immune deviation prevents the development of AHR, but associates significant inflammation in the lung (2). Thus, therapeutic interventions for asthma and allergy should focus more on inducing allergen-specific T-cell tolerance. Clonal deletion and clonal anergy are well-established mechanisms of peripheral tolerance. The additional intervention of clonal suppression mediated by the antigen-induced production of IL-10 and/or TGF-β by regulatory T cells has recently been described (3). Dendritic cell central role in the regulation of the local activation of allergen-specific Th2 cells has also been underlined by many studies (4). Dendritic cell manipulation and T cell suppression seem to be the not-too-distant future therapeutic steps in obtaining allergen specific tolerance. The authors focus on regulatory T cells (Th3, and the recently described Tr1) expressing suppressive cytokines and detail the mechanisms of action of IL-10, TGF-β and INF-α. Peptide induced T cell anergy is then discussed together with suppression induction by means of altered antigen presentation or by direct action of IL-10 and TGF-β. New data are brought describing the mechanisms of resistance of T cells against TGF-β induced suppression: endoglin and SMAD 7 negative regulation and on the tissue factors released by mast cells (histamine, PGE2) influence on tolerance induction. I hope that this joint initiative will bring the best and up-to-date contributions for publication from leading researchers and scientists and will succeed in addressing some original insights in the genetics, epidemiology, pathogenesis, diagnosis and treatment of allergic diseases. Enjoy reading them. Ioana Agache on behalf of the JMAs Working Group
IgE‐mediated allergy to wood dusts probably does not explain the high prevalence of respiratory symptoms among Swedish woodwork teachers
Authors: M. åhman, M. van Hage‐Hamsten, S. G. O. Johansson
Journal: Allergy (1995)

A previous study revealed an increased occurrence of work‐related respiratory complaints among Swedish woodwork teachers. For determination of whether an IgE‐mediated mechanism was the cause of the symptoms, 127 woodwork teachers and 111 reference subjects (other school personnel) in Stockholm gave serum for analysis of total IgE, Phadiatop, and RAST to extract of sawdust from five commonly used Scandinavian woods (pine, birch, juniper, alder, and linden). The total serum‐IgE level was similar in the woodwork teachers (geometric mean 35, range &lt;2–1700 kU/l) and the reference group (34, &lt;2–860 kU/l), and the frequency of positive Phadiatop was equal (29.9% and 31.5%, respectively). RAST was positive only in three cases, two reference subjects (birch and pine) and one woodwork teacher (alder). Hence, no correlation between exposure and sensitization to wood dust was found, and the results do not support the assumption that the complaints related to exposure to dusts from the examined Scandinavian woods are IgE mediated.
723-6 Hemodynamic Effects of Graded Oral Doses of a New Dopaminergic Analogue CHF 1035 in Patients with Congestive Heart Failure
Authors: Carmine Morisco, Bruno Ricciardelli, Luigi Argenziano, Virgilio Rendina, Guido laccarino, Carmine Vecchione, Alberto Umile, Massimo Volpe Bruno Trimarco
Journal: Journal of the American College of Cardiology (1995)
Overcoming the Pricing Power of Hospitals
Authors: Bob Kocher, Ezekiel J. Emanuel
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Surface Topography and Fine Structure of the Legionnaires' Disease Bacterium
Authors: THOMAS R. NEBLETT
Journal: Annals of Internal Medicine (1979)

Six clinical isolates of the Legionnaires' disease bacterium have been isolated from patients in two Michigan hospitals. These organisms were recovered and cultivated in vitro and the strains named by city of recovery and order of isolation Detroit 1 to 4 and Flint 1 and 2. All strains, studied by scanning and transmission electron microscopy preparations from 7-day growth on agar, showed similar characteristics. By scanning electron microscopy the cells appeared bacillary, straight, and slightly curved, and spindle shapes and forms with rounded ends were observed. Detroit 2 and 3 and Flint 1 strains showed cells with ends having reduced diameters, the cells resembling an old-fashioned rolling pin. Cell widths ranged from 0.29 to 0.39 µ, and average lengths varied from 1.60 to 2.34 µ. Filamentous forms as long as 9.8 µ were observed. Surfaces appeared quite wrinkled compared to that of an Escherichia coli control organism. As seen by transmission electron microscopy, fine structure included a multilayered cell wall characteristic of gram-negative bacteria that was irregular, reflecting wrinkling; plasma membrane; and periplasmic space. Distinct nucleoid, intracytoplasmic ribosomes and rare vacuoles were also seen. No evidence of a spore or an adversity-resistant body was observed.