tbuckley/cabot-search huggingface dataset:
Association of glutamine 27 polymorphism of beta 2 adrenoceptor with reported childhood asthma: population based study
Authors: E Hopes, C McDougall, G Christie, J Dewar, A Wheatley, I P Hall, P J Helms
Journal: BMJ (1998)

The prevalence of asthma in children has doubled over the past 25 years.1 Two common polymorphisms exist in the β adrenoceptor at amino acids 16 (glycine for arginine) and 27 (glutamic acid for glutamine). Both are functionally relevant in cultured cells, with the glycine 16 form of the receptor showing enhanced downregulation and the glutamic acid 27 form showing attenuated downregulation after exposure to β agonists.2 The glutamine 27 polymorphism is associated with raised IgE concentrations in families with a history of asthma, and with increased reactivity of the airways in people with asthma. 3 4 We measured the prevalence of these polymorphisms in a random population of children to identify their importance in the expression of reported asthma.

We approached children between the ages of 5 and 15 years (mean 10.5 years) and an accompanying parent who were attending the accident and …
High-Quality Learning for High-Quality Health Care
Authors: David C. Leach, Ingrid Philibert
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical Studies of Medical Care
Authors: Janet J. Fischer
Journal: Annals of Internal Medicine (1978)

III. Comments1 November 1978Clinical Studies of Medical CareJanet J. Fischer, M.D.Janet J. Fischer, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-89-5-864_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMost microbiology courses for medical students are given during the first 2 years of medical school, and are taught by Ph.D.s who emphasize molecular biology. The current National Board examination consisting mainly of questions on molecular biology, virology, and basic immunology is an example of the emphasis in these courses. This is important for physicians entering research and for a basic understanding of the field for teachers. However, most of our students enter the practice of clinical medicine and with this background are ill-prepared for the cases of bacterial, and often nosocomial, infections that they see on the medical wards.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Janet J. Fischer, M.D.Affiliations: University of North Carolina School of Medicine PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1978Volume 89, Issue 5_Part_2 Page: 864-864 Keywords Clinical microbiology Immunology Microbiology Molecular biology Nosocomial infections Virology ePublished: 1 December 2008 Issue Published: 1 November 1978 PDF downloadLoading ...
Licorice and Hypertension
Authors: Louis Pelner
Journal: JAMA (1969)

<h3>To the Editor:—</h3> Two recently observed patients with hypertension again point out the prime importance of a detailed history, especially a question with regard to the intake of licorice or licorice-containing products in patients with hypertension. A 55-year-old woman with previously normal blood pressure presented with a blood pressure of 180/110. The patient was placed on a regimen of one tablet of a cryptenamine and a chlorothiazide derivative mixture (Diutensen) daily. About a week later she was found to be paralyzed and unable to move all four extremities. Hypokalemia was suspected and indeed found (2.2 mEq/liter). For the preceding six months this patient had been ingesting one package of licorice candy every night as an aid to the treatment of constipation. The hypokalemia and the paralysis were undoubtedly increased by the use of the chlorothiazide drug even though licorice itself can cause both the hypokalemia and the paralysis. The paralysis
Abstract 2660: Downregulation of Bora gene expression in human tumor cells results in radioresistance by promoting repair of double strand breaks
Authors: Junmei Hou, Bo Qin, Zhenkun Lou, Liewei Wang
Journal: Cancer Research (2011)

Abstract DNA double-strand breaks (DSBs) are highly cytotoxic lesions caused by genotoxin such as ionizing radiation (IR). Following DSB, cells activate the DNA-damage response pathway by activating protein kinases such as ATM, ATR and DNA-PK, which then trigger histone H2AX phosphorylation and the accumulation of proteins such as Mediator of DNA damage checkpoint protein 1 (MDC1), 53BP1, and BRCA1 into IR-induced foci. This process initiates the repair of DSB. Previously we have identified a novel biomarker for radiation response, Bora, by using a genome-wide association approach using data generated with 300 human lymphoblastoid cell liens. Bora is known as a cofactor of Aurora-A, which is involved in mitosis regulation. During G2, Aurora-A, in complex with Bora, phosphorylates Plk1 at Thr-210. Activated Plk1 phosphorylates Cdc25C and Wee1, which induces activation of cyclin B-cdk1 complexes and promotes mitotic entry. In this study, we want to determine the underlying mechanisms by which Bora regulates response to IR. We found that knockdown of Bora in human cancer cell lines including HupT3, MIAPaCa-2 and Hela (siBora) exhibit increased clonogenic survival rate in response to IR, an observation that is opposite from the effect of Plk1 knockdown, suggesting a different mechanism involved. Knockdown of Bora also desensitize cancer cells to chemotherapeutic agents including gemcitabine and oxiplatin. This enhanced resistance to genotoxin is primarily due to increased DNA DSB repair. More than 90% of DSBs were repaired in siBora cells compared with 60% in control cells 8 hours after cell exposure to 2 Gy IR. Upon IR, more cells with Bora knockdown retained in G2-M phase compared with control. Furthermore, Bora directly interacts with BRCT domain of MDC1 via its C terminus, and over expression of Bora can abolish MDC1 foci formation induced by IR. All of these observations suggested a role of Bora in DNA damage response pathway and in turn, in chemo-radio resistance. Indeed, overexpression of the full length or C-terminus of Bora sensitized cancer cells to IR treatment, while the N-terminal Bora did not have significant effect on IR response. In summary, we have identified a novel function of Bora involved in DNA damage and repair pathway, which indicates a broad role of Bora in both tumorgenesis and chemo-radio resistance. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2660. doi:10.1158/1538-7445.AM2011-2660
Contrast-enhanced magnetic resonance angiography is the most accurate noninvasive imaging technique for carotid stenosis
Authors: Thomas E. Feasby
Journal: Annals of Internal Medicine (2009)

ACP Journal Club20 October 2009Contrast-enhanced magnetic resonance angiography is the most accurate noninvasive imaging technique for carotid stenosisThomas E. Feasby, MDThomas E. Feasby, MDUniversity of Calgary, Calgary, Alberta, Canada (T.E.F.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-151-8-200910200-02015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationChappell FM, Wardlaw JM, Young GR, et al. Carotid artery stenosis: accuracy of noninvasive tests—individual patient data meta-analysis. Radiology. 2009;251:493-502. https://pubmed.ncbi.nlm.nih.gov/19276319Clinical Impact RatingsHospitalists: Neurology: Author, Article, and Disclosure InformationAffiliations: University of Calgary, Calgary, Alberta, Canada (T.E.F.)This article was published at Annals.org on 6 October 2009. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 20 October 2009Volume 151, Issue 8Page: JC4-15KeywordsAngiographyArteriesCarotid endarterectomyComputed axial tomographyImaging techniquesMagnetic resonance angiographySpecificityStenosisTransient ischemic attacksUltrasound imaging ePublished: 20 October 2009 Issue Published: 20 October 2009 Copyright & PermissionsCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Nuclear Receptor Coregulators: Cellular and Molecular Biology*
Authors: Neil J. McKenna, Rainer B. Lanz, Bert W. O’Malley
Journal: Endocrine Reviews (1999)

Nuclear receptor coregulators are coactivators or corepressors that are required by nuclear receptors for efficient transcripitonal regulation. In this context, we define coactivators, broadly, as molecules that interact with nuclear receptors and enhance their transactivation. Analogously, we refer to nuclear receptor corepressors as factors that interact with nuclear receptors and lower the transcription rate at their target genes. Most coregulators are, by definition, rate limiting for nuclear receptor activation and repression, but do not significantly alter basal transcription. Recent data have indicated multiple modes of action of coregulators, including direct interactions with basal transcription factors and covalent modification of histones and other proteins. Reflecting this functional diversity, many coregulators exist in distinct steady state precomplexes, which are thought to associate in promoter-specific configurations. In addition, these factors may function as molecular gates to enable integration of diverse signal transduction pathways at nuclear receptor-regulated promoters. This review will summarize selected aspects of our current knowledge of the cellular and molecular biology of nuclear receptor coregulators.
The Pet Separation Syndrome
Authors: John F. Burnum
Journal: Annals of Internal Medicine (2000)

Letters15 August 2000The Pet Separation SyndromeJohn F. Burnum, MDJohn F. Burnum, MDUniversity of Alabama; Tuscaloosa, AL 35487-0326 (Burnum)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-133-4-200008150-00029 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I have recently come to appreciate that the separation of hospitalized patients from their pet dogs can make both parties ill and can therefore be called the “pet separation syndrome.”Ms. E.F., a woman with severe asthma, left the hospital against advice because she longed to see her pet Chihuahua, Chico, who was tearing up the apartment looking for her. Mr. H.S., who was dying of hemochromatosis, spoke of little but his dog, Spot. Back home, Spot refused to eat and died in 2 weeks. Yearning to see his distraught dachshund, Alphi, Mr. C.S. refused further hospital ...References1. Stern M. Psychological elements of attachment to pets and responses to pet loss. J Am Vet Med Assoc. 1996;209:1707-11. MedlineGoogle Scholar2. Sable P. Pets, attachment, and well-being across the life cycle. Soc Work. 1995;40:334-41. MedlineGoogle Scholar3. Beck AM, Katcher AH. Between Pets and People: The Importance of Animal Companionship. West Lafayette, IN: Purdue Univ Pr; 1996. Google Scholar4. Edney AT. Companion animals and human health: an overview. J R Soc Med. 1995;88:704p-8p. MedlineGoogle Scholar5. Allen DT. Effects of dogs on human health. J Am Vet Med Assoc. 1997;210:1136-9. MedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: John F. Burnum, MDAffiliations: University of Alabama; Tuscaloosa, AL 35487-0326 (Burnum) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byUnderstanding Links Between College Students’ Childhood Pet Ownership, Attachment, and Separation Anxiety During the Transition to CollegeLung Transplant Recipients Holding Companion Animals: Impact on Physical Health and Quality of LifeRisques infectieux des animaux de compagnie 15 August 2000Volume 133, Issue 4Page: 313-314KeywordsArrhythmiaAsthmaBlood pressureExerciseHemochromatosisLipidsMyocardial infarctionParoxysmal atrial tachycardiaSleepStroke ePublished: 15 August 2000 Issue Published: 15 August 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Lytic effect of cytotoxic lymphocytes on oral epithelial cells in Behcet's disease
Authors: G. REIMER, S. STEINKOHL, D. DJAWARI, O.P. HORNSTEIN
Journal: British Journal of Dermatology (1982)

The effect of blood lymphocytes on syngeneic oral epithelial cells was studied in twelve patients with Behçet's disease (BD) and twenty‐one patients with recurrent aphthous ulcers (RAU). The control group consisted of twenty‐five patients with non‐aphthous skin disease and eight healthy individuals. Primary cell lines obtained from oral mucosa by suction blistering and subsequent enzymatic dissociation were used as target cells. Using a modified 51chromium release macro‐assay, a significant lytic effect due to antibody‐independent lymphocytotoxicity could be demonstrated in patients with BD, but no significant lysis of target cells was found in the RAU patients compared with the control group. These results provide further evidence that antibody‐independent lymphocytotoxicity may play an important role in oral ulceration in BD.
Late Outcome After Coronary Artery Bypass Graft Surgery in Patients &lt;40 Years Old
Authors: John K. French, Douglas S. Scott, Ralph M.L. Whitlock, Heather D. Nisbet, Margaret Vedder, Alan R. Kerr, Warren M. Smith
Journal: Circulation (1995)

Background Randomized trials confirm the long-term efficacy of coronary artery bypass graft surgery (CABG), although there are no randomized data in patients &lt;40 years old. Because these patients have been reported to have an early recurrence of symptoms, the long-term postoperative outcome was examined. Methods and Results The long-term outcome of patients (n=221) &lt;40 years old undergoing CABG at Green Lane Hospital, New Zealand, from 1970 to 1992 was determined. The 30-day mortality rate was 1.8% for initial and 9.5% for redo CABG. The median times to angina or myocardial infarction (recurrent ischemic event), further intervention, and death were 6.0, 9.6, and 14.2 years, respectively. Factors associated with increased late mortality on univariate analysis included end-systolic volume (ESV) ≥80 mL ( P =.004; 10-year mortality 19% versus 39% ESV ≥80 mL), no internal mammary conduit ( P =.01), no lipid-modifying therapy ( P =.005), and no postoperative aspirin use ( P =.0002); the latter was also associated with increased recurrent ischemic events ( P =.04) or increased reintervention ( P =.02). On stepwise logistic regression analysis, factors associated with increased late mortality were increasing ESV ( P =.004), no internal mammary artery conduit ( P =.009), diabetes ( P =.04), and no postoperative aspirin ( P =.02); the latter was also associated with increased recurrent ischemic events ( P =.02). Hypercholesterolemia (≥6.5 mmol/L) was present in 65% of patients at presentation and 45% at follow-up. Conclusions To attempt to prevent recurrent ischemia or late death, patients &lt;40 years old who require CABG should receive internal mammary conduits, aspirin, lipid-modifying therapy, therapy to inhibit ventricular dilatation, and strict diabetes management.
On Certain Abnormal Ballistic Complexes: Their Relationships to Other Mechanical and Electrical Events of the Cardiac Cycle
Authors: PETER T. KUO, TRUMAN G. SCHNABEL, CALVIN F. KAY
Journal: Circulation (1952)

Ballistocardiograms were recorded simultaneously with intra-atrial and intra-aortic pressure curves, heart sounds, electrokymograms and electrocardiograms in patients with various types of heart disease. In several of these subjects, in addition to the usual ballistic waves, abnormal sets of ballistic complexes occurred. In some individuals, one or more of these abnormal ballistic complexes was so prominent that it dominated the entire ballistocardiogram. By correlating the abnormal ballistic waves with other dynamic and electrical events, we have secured information which throws light on the genesis of certain abnormal waves and of the so-called H wave in the ballistocardiogram.
Full-Time Clinicians as Teachers
Authors: Dan C. Bird
Journal: Annals of Internal Medicine (1993)

Letters1 March 1993Full-Time Clinicians as TeachersDan C. Bird, MDDan C. Bird, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-5-199303010-00029 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:A recent issue of Annals contained two articles [1, 2] that raise serious questions about the ability of academic faculty to do adequate examinations and to supervise housestaff. I attended for 15 years at the County Hospital in Los Angeles and share that opinion.My colleagues and I do not miss 40% to 60% of cardiac diagnoses when valvular heart conditions are present. In the trenches, we ferret out the signs and symptoms that require further evaluation and stop workups when appropriate. We call this “the practice of medicine.”The appalling record among the housestaff at Duke ...References1. St. Clair EW, Oddone EZ, Waugh RA, Corey GR, Feussner JR. Assessing housestaff diagnostic skills using a cardiology patient simulator. Ann Intern Med. 1992; 117:751-6. Google Scholar2. Noel GL, Herbers JE Jr, Caplow MP, Cooper GS, Pangaro LN, Harvey J. How well do internal medicine faculty members evaluate the clinical skills of residents. Ann Intern Med. 1992; 117:757-65. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1993Volume 118, Issue 5Page: 398KeywordsHealth careHeart diseasesSigns and symptoms Issue Published: 1 March 1993 CopyrightCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
X-ray CT guided fault-free photothermal ablation of metastatic lymph nodes with ultrafine HER-2 targeting W18O49 nanoparticles
Authors: Da Huo, Jian He, Hui Li, Ai J. Huang, Hui Y. Zhao, Yin Ding, Zheng Y. Zhou, Yong Hu
Journal: Biomaterials (2014)
Health Indices for Greater London and New York, 1931-40
Authors: P. Stocks
Journal: BMJ (1941)

recurs rapidly, a suitable needle may be inserted and con- nected to a rubber tube attached to a simple under-water drainage bottle as used for closed drainage of empyemata (Fig. 3).This will afford great relief, but has the disadvan- TO patlent.FIG.3.-Simple under-water drainage bottle.tage that, as air is expelled during cough, it may result in the development of a low intrapleural pressure, with too rapid re-expansion of the lung, giving the pleuro-bronchial fistula no chance to heal.It may be more satisfactory, in a patient who is not distressed by an intrapleural pressure equal to atmospheric, to leave a needle in situ open to the air, preferably through a loose cotton-wool filter.If, how- ever, the patient is distressed with an atmospheric intra- pleural pressure the arrangement shown in Fig. 4 may be "'IT°P int .C ~~~F IG. 4.-Apparatus for under-water drainage of tension pneumothorax, with safety-valve.
Triiodothyronine enhances the regenerative capacity of the liver following partial hepatectomy
Authors: Raza Malik, Neil Mellor, Clare Selden, Humphrey Hodgson
Journal: Hepatology (2003)

This study investigates the effects of administering a primary mitogen, triiodothyronine (T 3 ), at the time of 70% partial hepatectomy (PH) in the rat, thus combining the 2 distinct pathways of liver growth: direct hyperplasia and compensatory regeneration. T 3 enhances the proliferative response of hepatocytes within the liver following PH. Flash bromodeoxyuridine (BrdU) labeling showed a cell proliferation index 24 hours after PH alone of 26.5% ± 2.8%; when T 3 was administered at PH, it increased to 39.5% ± 5.0% ( P &lt; .01 compared with PH alone). Continuous BrdU labeling performed every 6 hours between 15 and 72 hours following surgery showed an index of 84.0% ± 4.0% when T 3 was administered at PH compared with 71.0% ± 4.0% with PH alone ( P &lt; .01 compared with PH alone). This increase in cell proliferation resulted in a larger liver mass at 4 days in rats receiving T 3 at PH compared with PH alone ( P &lt; .05 compared with PH alone). The difference in liver mass was matched with corresponding increases in total DNA and total protein levels as well as cell division, as confirmed by the frequent demonstration of twin daughter cells on histology. In conclusion, this study shows that a single dose of T 3 enhances the regenerative capacity of the liver following PH. The ability to enhance cell proliferation during compensatory hyperplasia following PH could be therapeutically valuable if applicable to humans.
Signaling Switch of the Axon Guidance Receptor Robo3 during Vertebrate Evolution
Authors: Pavol Zelina, Heike Blockus, Yvrick Zagar, Amélie Péres, François Friocourt, Zhuhao Wu, Nicolas Rama, Coralie Fouquet, Erhard Hohenester, Marc Tessier-Lavigne, Jörn Schweitzer, Hugues Roest Crollius, Alain Chédotal
Journal: Neuron (2014)
Noninvasive assessment and differentiation of left ventricular outflow obstruction with Doppler ultrasound.
Authors: L Hatle
Journal: Circulation (1981)

Blood flow velocities in the left ventricle and the ascending aorta were recorded noninvasively with Doppler ultrasound. The ultrasound beam was aligned as much as possible to the direction of velocity, using the frequency shift in the audio signal as a guide to obtain velocities as close as possible to those present. From the maximal velocity recorded by continuous-wave Doppler, a peak pressure drop was calculated in 24 patients with aortic valve stenosis and nine with fixed subaortic stenosis. Fourteen patients with aortic stenosis and three with fixed subaortic stenosis were catheterized. In these patients, the correlation between calculated pressure drops and those obtained by pressure recording was good (r = 0.85). The pressure drop can be underestimated by underestimating velocity, but cannot be overestimated. With pulsed Doppler, the level of obstruction can be determined.