Mechanisms of Hyponatremia in Chronic Congestive Heart Failure
Authors: TERUO TAKASU
Journal: Annals of Internal Medicine (1961)

Article1 September 1961Mechanisms of Hyponatremia in Chronic Congestive Heart FailureTERUO TAKASU, M.D., NORMAN LASKER, M.D., ROBERT J. SHALHOUB, M.D.TERUO TAKASU, M.D.Search for more papers by this author, NORMAN LASKER, M.D.Search for more papers by this author, ROBERT J. SHALHOUB, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-55-3-368 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRecent studies have shown that several factors may contribute to the hyponatremia of congestive heart failure. These include electrolyte shifts between intracellular and extracellular compartments (1), abnormal antidiuretic responses (2-6), glomerulotubular imbalance (7-11), lowered osmoreceptor settings (7, 8, 12, 13), and persistence of water intake despite dilution of body fluids. These diverse factors indicate the complexity of this problem and help explain the erratic responses to a strictly empirical approach to therapy.This study was designed primarily to elucidate the renal mechanisms contributing to the pathogenesis of hyponatremia in congestive heart failure and to devise a diagnostic procedure for classification...References1. JAENIKEWATERHOUSE JRC: Body fluid alterations during the development of and recovery from hyponatremia in heart failure. Amer. J. Med. 26: 862, 1960. CrossrefGoogle Scholar2. SCHWARTZBENNETTCURELOPBARTTER WBWSFC: A syndrome of renal sodium loss and hyponatremia probably resulting from inappropriate secretion of antidiuretic hormone. Amer. J. Med. 23: 529, 1957. CrossrefMedlineGoogle Scholar3. LEAFMAMBY AAR: An antidiuretic mechanism not regulated by extracellular fluid tonicity. J. Clin. Invest. 31: 60, 1952. CrossrefMedlineGoogle Scholar4. 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SHALHOUB, M.D.Affiliations: Jersey City, New JerseyReceived for publication April 28, 1961.From the Renal and Electrolyte Laboratory, Department of Medicine, Seton Hall College of Medicine and Dentistry, and The Jersey City Medical Center, Jersey City, N. J.Supported by a grant from the New Jersey Heart Association.Requests for reprints should be addressed to Norman Lasker, M.D., Renal Division, Department of Medicine, Seton Hall College of Medicine and Dentistry, Jersey City, N. J. 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