tbuckley/cabot-search huggingface dataset:
Hyperparathyroidism Due to Parathyroid Adenoma and Carpal Tunnel Syndrome
Authors: LUBOMIR J. VALENTA
Journal: Annals of Internal Medicine (1975)

Letters1 April 1975Hyperparathyroidism Due to Parathyroid Adenoma and Carpal Tunnel SyndromeLUBOMIR J. VALENTA, M.D.LUBOMIR J. VALENTA, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-82-4-541 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA 44-year-old woman was examined whose first symptom of hyperparathyroidism was nephrolithiasis. This was resolved by ureteromeatotomy and passage of the calculus. The calculus was composed of calcium phosphate and oxalate. Routine biochemical studies showed serum calcium levels varying between 12.4 and 13 mg/100 ml (normal, 9 to 11 mg/100 ml); serum inorganic phosphorus, 1.7 to 2.1 mg/100 ml (normal, 2.5 to 4.5 mg/100 ml); and elevation of alkaline phosphatase to 4.85 Bessey Lowry U (normal, 0.8 to 2.3 Bessey Lowry U). Urinary clearance of phosphorus and urinary calcium were normal. Serum radioimmunoassayable parathyroid hormone was 300 and 403 pg/ml...References1. WEINSTEINDICKGRANTHAM JHS: Pseudogout, hyperparathyroidism and carpal tunnel syndrome. A case report. J Bone Joint Surg [Am] 50:1669-1674, 1968 CrossrefMedlineGoogle Scholar2. DAWKINSTASHJIANCASTLEMAN RAB: Hyperparathyroidism due to clear cell hyperplasia. Am J Med 54:119-126, 1973 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: LUBOMIR J. VALENTA, M.D.Affiliations: Department of Medicine School of Medicine Michigan State University East Lansing, Michigan 48823 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited by[NO TITLE AVAILABLE]The entrapment neuropathies 1 April 1975Volume 82, Issue 4Page: 541-542KeywordsCalciumHyperparathyroidismParathyroid hormoneParathyroid tumorsPhosphatasesPhosphatesPhosphorus ePublished: 1 December 2008 Issue Published: 1 April 1975 PDF downloadLoading ...
Mutations within the E2 and NS5A protein in patients infected with hepatitis C virus type 3a and correlation with treatment response
Authors: Christoph Sarrazin, Ilka Kornetzky, Brigitte Rüster, Jung-Hun Lee, Bernd Kronenberger, Katharina Bruch, Kurt W. Roth, Stefan Zeuzem
Journal: Hepatology (2000)

Defined regions of hepatitis C virus (HCV) envelope 2 (E2), PePHD, and nonstructural 5A (NS5A) protein (PKR-binding domain) have been shown to interact with interferon alfa (IFN-α)-inducible double-stranded RNA-activated protein kinase (PKR) in vitro , suggesting a possible mechanism of HCV to evade antiviral effects of IFN-α. The clinical correlation between amino acid mutations within the E2 PePHD or the NS5A PKR-binding domain and response to antiviral treatment in HCV-3a-infected patients is unknown. Thirty-three patients infected with HCV-3a isolates were treated with IFN-α with or without ribavirin. The carboxyterminal half of E2 and of the NS5A gene were sequenced. Sixteen patients achieved a sustained virological response (SR), 6 patients an end-of-treatment response with relapse thereafter (ETR), and 11 patients were nonresponders (NR). Within the PePHD of the E2 protein 0.5 (range, 0-2) mutations were observed in SR patients, whereas the number of mutations in ETR or NR patients was 0.2 (0-1). Quasispecies analyses showed almost no heterogeneity. The mean number of mutations within the PKR-binding domain of the NS5A protein was 1.6 (range, 0-4) in SR patients, 1 (0-2) in ETR patients, and 1.6 (0-3) in NR patients. Patients with higher numbers of mutations within the E2 or NS5A region showed a trend towards lower pretreatment viremia. Phylogenetic and conformational analyses of E2 or NS5A sequences allowed no differentiation between sensitive and resistant isolates. However, mutations within the E2 PePHD in SR patients were frequent, and hydrophobic mutations within the hydrophilic area of PePHD at codon 668 and 669 were exclusively observed in sustained virological responders.
The Biomechanical effects of treadmill training on running performance
Authors: B. C. Elliott, F. S. Pyke, A. D. Roberts, A. R. Morton
Journal: British Journal of Sports Medicine (1974)

The biomechanics of overground running were compared before and after a month training period which comprised 16 thirty-minute sessions of short duration (5 seconds work, 10 seconds rest) high intensity (4.69 m/sec 20-25% grade) interval treadmill work. For the eight subjects filmed there were no significant changes in support and non support time, stride length or stride rate while running at 3.58 m/sec that could be attributed to the treadmill training regime. This training programme produced significant gains in aerobic and anaerobic metabolism but was not an effective developer of speed.
The Meaning of Quality in Medical Care
Authors: Philip Caper
Journal: New England Journal of Medicine (1974)

I am interested in the quality of personal health services from two points of view. The first is that, as a physician, I have been taught throughout my professional career that I had an absolute obligation to my patients to provide them with the highest quality medical care within my reach, almost without regard to cost. My training in a large, academically oriented state-subsidized teaching hospital followed by experience in a municipal hospital accentuated this tendency by insulating my patients from the cost implications of my "high-quality," extensive and exhaustive diagnostic and therapeutic efforts.The rapid growth of public and . . .
Diet and prevention of coronary heart disease: the potential role of phytochemicals
Authors: F Visioli
Journal: Cardiovascular Research (2000)

Epidemiological studies, and some clinical trials, demonstrate that a proper diet reduces the rate of occurrence of cardiovascular disorders. Several in vitro studies suggest that some components of plant foods, most of which sharing a phenolic structure, are endowed with interesting 'pharmacological activities'. This article reviews the evidence that links a high dietary intake of phytochemicals from various sources with a reduced incidence of coronary heart disease.
Rencontre et dialogue
Authors: E. Minkowski
Journal: Psychotherapy and Psychosomatics (1960)

Depuis le petit volume de Martin Buber: “Je-tu”, de nos jours et a juste titre, ce “jetu” ou le “nous” (L. Binswanger) ou encore la rencontre humaine se trouvent places au centre de nos preoccupations et de nos investigations. La psychologie a la 2e personne est venue battre en breche l’ancienne, pour ne pas dire la seculaire, opposition de la psychologie a la le et a la 3e personne, ou encore, de la psychologie subjective et de la psychologie objective, de l’introspection et de l’extrospection. Le “jetu” a ouvert des horizons nouveaux et tout en nous rapprochant de l’essentiellement humain, nous a menes a reviser, voire a abandonner, maintes conceptions courantes, pour solides et inattaquables qu’elles aient pu paraitre jusque la.
General Practice — An Analysis and Some Suggestions
Authors: Anthony D. Bower
Journal: New England Journal of Medicine (1963)

EVIDENCES of the dislocations wrought by science in the basic scheme of things may be seen everywhere, and the problems created must be faced. Authors such as Rachel Carson, C. P. Snow and J. B. Priestley have pointed out the need for a clearer understanding of what science has done to man as well as for man. The atomic bomb, the population explosion and the prospective elimination of the balance of nature suggest that man is to be responsible for what does or does not survive on this planet.Definition of the ProblemViewed in this light, scientific achievement cannot . . .
Associations of β2‐adrenergic receptor genotypes and haplotypes with wheezing illness in Taiwanese schoolchildren
Authors: Y.‐L. Lee, S.‐T. Wang, C.‐H. Tsai, Y. L. Guo
Journal: Allergy (2009)

Increasing attention was focused on the beta2-adrenergic receptor gene (ADRB2), whose genetic variability has been implicated as a risk factor for asthma-related phenotypes. However, only a few studies reported the associations by utilizing haplotypic approaches. We therefore examined the relationship of childhood wheezing illness with polymorphisms at codons 16 and 27, and evaluated the influence of polymorphisms individually and in combination as haplotypes. We conducted a genetic case-control study comprising 215 wheezing children and 183 nonwheezing controls, all of whom were selected from 2524 fourth- to ninth-grade schoolchildren in southern Taiwan. All participants were homozygous at the ADRB2 Thr164 locus. After controlling for possible confounders, ADRB2 Glu27 allele was significantly associated with wheezing illness in all genetic models, but the risks on Arg16Gly genotypes were inconclusive. Estimated frequencies for the three main hyplotypes were Arg16/Gln27 57.2%, Gly16/Gln27 35.3%, Gly16/Glu27 7.4% in wheezing children, and Arg16/Gln27 56.3%, Gly16/Gln27 32.2%, Gly16/Glu27 10.4% in controls. The protective effect of Gly16/Glu27 haplotype remained relative to all other ADRB2 haplotypes [adjusted relative risk (aRR) = 0.58; 95% confidence interval (CI) 0.35-0.97]. As compared with children without Gly16/Glu27 haplotype, those with Gly16/Glu27 haplotype had a significantly lower risk for wheezing illness (aRR = 0.56; 95% CI 0.33-0.99). The copy numbers of Gly16/Glu27 haplotype also showed a clear dose-response relationship on the decreased risks. No significant association was found with the prevalence of wheezing illness for other haplotypes. We concluded that ADRB2 Glu27 allele and Gly16/Glu27 haplotype were significantly protective factors for wheezing illness in Taiwanese schoolchildren.
Latent morbidity after abortion.
Authors: C Buck, K Stavraky
Journal: BMJ (1973)

Acute tubular necrosis 2012{7 dense 4 4 7Subacute glomerular or vascular disease 5 2 faint 1 2 1 hypertension in one); only one of these patients recovered some renal function.Urography was performed during the first two weeks of acute renal failure, always before the onset of the recovery phase, 140 ml of methylglucamine iothalamate (Contrix 28; 28% iodine) (being given in a single injection lasting less than five minutes.Plain films and tomograms were taken before and up to 24 hours after the injection of the contrast medium.The findings are sum- marized in the table.In the 20 cases of acute tubular necrosis it may *be seen that, contrary to the experience of Dr. Cattell and his oolleagues, we found no evidence of a nephrogram in four cases and a delayed nephrogram in four others.Nevertheless, all patients recovered completely and further examination failed to reveal any other assodated renal disease.Our findings in subacute glomerular or vascular disease are similar to those of Dr. Cattell.The reason for the discrepancy between our observations and tihose of Dr. Cattell and his colleagues in acute tubular necrosis is not immediately apparent.It may be related to the fact that we have studied a larger number of patients and thus observed the full spectrum of urographic -patterns in acute tubular necrosis.Alternatively, it may result from the criteria used to assert the presence of a nephrogram.In our experience it may be difficult to decide whether or not a nephrogram is present.An increase in radiodensity noted between control and post- injection films may be due to slight changes in technical conditions despite constant kilovoltage (progressive warming up of the tube, instability of the power supply, physical characteristics of individual film cassettes).As criteria for the presence of a nephro- gram we require an increased radiodensity of the kidney not only in reference to control films but mostly in reference to adjacent structures such as the psoas or the sinusal fat.We conclude that, unfortunately, the nephrographic patterns are not sufficiently distinctive to lead to an accurate diagnosis in non-obstructive acute renal failure.-Weare, etc.,
Extracellular adenosine triphosphate activates calcium mobilization in human phagocytic leukocytes and neutrophil/monocyte progenitor cells.
Authors: D S Cowen, H M Lazarus, S B Shurin, S E Stoll, G R Dubyak
Journal: Journal of Clinical Investigation (1989)

We have examined the ability of extracellular ATP to elicit intracellular Ca2+ mobilization in a broad range of human leukocytes at particular stages of hematopoietic differentiation. The average cytosolic [Ca2+] in various leukocyte populations was measured in Fura 2-loaded cell suspensions while the cytosolic [Ca2+] in individual, Indo 1-loaded leukocytes was assayed by flow cytometric methods. Utilizing normal blood- and marrow-derived cells, human leukemic cell lines, and mononuclear cell fractions derived from the blood of patients with various leukemias, we have found that ATP-induced Ca2+ mobilization appears restricted to leukocytes of neutrophil/monocyte ontogeny. Significant ATP-induced increases in cytosolic [Ca2+] were observed in neutrophils, monocytes, and myeloid progenitor cells as immature as myeloblasts, but not in lymphocytes. Extensive characterization of the ATP-induced changes in [Ca2+] observed in the HL-60 promyelocytic cell line have indicated these Ca2+-mobilizing effects of ATP can be correlated with an activation of inositol phospholipid breakdown via the occupation of P2-purinergic receptors Significantly, of the various agonists (FMLP, platelet-activating factor, LTB4, and ATP) which elicit equivalent and maximal Ca2+ mobilization in mature neutrophils and monocytes, ATP was the most efficacious stimulant of Ca2+ mobilization in immature neutrophil/monocyte precursors. Thus, expression of putative P2-purinergic receptors for ATP appears to precede expression of other receptor types known to activate the inositol phospholipid signaling cascades in terminally differentiated phagocytes.
Early alterations in the function of sarcoplasmic reticulum in a naturally occurring model of congestive cardiomyopathy
Authors: N. A STALEY, G. R NOREN, S. EINZIG
Journal: Cardiovascular Research (1981)

In a naturally occurring model of congestive cardiomyopathy-round heart disease of turkeys, Ca2+ transport of isolated cardiac sarcoplasmic reticulum was evaluated at 1, 10, 28, and 56 days of age. Ca2+ binding in round heart disease birds was reduced to between 55% and 75% of values measured in age-matched commercial control turkeys (P < 0.05 to < 0.01). Similarly, Ca2+ uptake in round heart disease birds was reduced to between 52% and 87 % of values measured in age-matched commercial control turkeys (P < 0.05 and < 0.01). Ca2,-stimulated ATPase values were similar in 1-, 10-, and 28-day-old round heart disease and commercial control turkeys. However at 56 days of age, when all round heart disease birds showed moderate to marked left ventricular dilatation, Ca2+-stimulated ATPase was reduced to 75% of control values (P < 0.05). Depression of Ca2+ binding and Ca2+ uptake preceded the appearance of cardiac dilatation and may contribute to the pathogenesis of round heart disease. Depression of Ca2+ -stimulated ATPase, present only after cardiac dilatation developed, appears to be secondary to cardiac failure. Sarcoplasmic reticulum function in round heart disease birds immunosuppressed by cyclophosphamide treatment (40 mg·kg−1·d−1 for the first 4 days of age) was evaluated at 10 days of age. This treatment increased Ca2+ binding by 73% (P < 0.05), and Ca2+ uptake by 58% (P < 0.01) over values measured in untreated round heart disease birds. Reversal of the altered Ca2+ transport in sarcoplasmic reticulum by early immunosuppression supports the hypothesis that the immune system plays an integral part in the development of the congestive cardiomyopathy of round heart disease.
How well does stool form reflect colonic transit?
Authors: L P Degen, S F Phillips
Journal: Gut (1996)

BACKGROUND: Watery stools are equated with rapid and hard stools with slow intestinal transit; however, the relation between stool form and transit through specific regions of the gut is not clear cut. In addition, more information is needed on interindividual variability of these measurements. AIM: To examine the relations between stool form and gastric emptying, small bowel and colonic transit. METHODS: Regional gut transit was assessed scintigraphically and segmental colonic transit was also quantified by radio-opaque markers. On two occasions, 32 healthy volunteers (12 men, 20 women) were studied, women during the follicular and luteal phases of menstruation, men twice within a similar four week period. Diets were standardised and stool form was recorded on a seven point scale. RESULTS: Women had significant harder stools; hard stools were correlated significantly with slow transit and loose stools with fast transit through the colon. CONCLUSIONS: Stool form could not be related to gastric emptying or small bowel transit.
Oedema in Rheumatoid Arthritis: Changes in the Coefficient of Capillary Filtration
Authors: M. I. V. Jayson, J. S. Barks
Journal: BMJ (1971)

The rate of formation of tissue fluid for a given increase of venous pressure and for a known volume of tissue has been measured in the forearm. There is a significant increase in this figure in rheumatoid arthritis and a still greater increase in patients who develop recurrent oedema. This increase could not be attributed to steroid or phenylbutazone therapy, nor to a fall in the serum albumin. The results imply that there is some generalized abnormality in capillary function in rheumatoid disease and that this change is not limited to the joints.
Ventricular Fibrillation During Selective Angiocardiography
Authors: George G. Rowe
Journal: JAMA (1965)

Adequate grounding of an electromechanical injector does not exclude the delivery of an electrical shock to a patient during injection of contrast substance. Seven episodes of ventricular fibrillation which occurred during cineangiocardiography indicated the possibility that they were produced by an electrical transient. Several power injectors were tested and all produced the same type of electrical discharge. A simple circuit which will eliminate the electrical discharge can help to reduce the risk of electromechanical injection.
Radiofrequency catheter ablation for management of symptomatic ventricular ectopic activity
Authors: Dennis Wei-Xi Zhu, James D. Maloney, Tony W. Simmons, Junichi Nitta, David M. Fitzgerald, Richard G. Trohman, Dirar S. Khoury, Walid Saliba, Karen M. Belco, Carlos Rizo-Patron, Sergio L. Pinski
Journal: Journal of the American College of Cardiology (1995)
Venous limb gangrene during overlapping therapy with warfarin and a direct thrombin inhibitor for immune heparin‐induced thrombocytopenia
Authors: Maureen A. Smythe, Theodore E. Warkentin, Jennifer L. Stephens, Dana Zakalik, Joan C. Mattson
Journal: American Journal of Hematology (2002)

We report two patients with deep-vein thrombosis complicating immune heparin-induced thrombocytopenia who developed venous limb gangrene during overlapping therapy with a direct thrombin inhibitor (lepirudin or argatroban) and warfarin. In both patients, therapy with the direct thrombin inhibitor was interrupted during persisting severe athrombocytopenia while warfarin administration continued. Both patients exhibited the typical feature of a supratherapeutic international normalized ratio (INRs, 5.9 and 7.3) that has been linked previously with warfarin-associated venous limb gangrene. These data suggest that warfarin anticoagulation be postponed in patients with acute heparin-induced thrombocytopenia until substantial recovery of the platelet count has occurred.
Executions should use a single drug and be overseen by medical personnel, expert panel says
Authors: M. McCarthy
Journal: BMJ (2014)

Executions by lethal injection should be carried out with a one drug protocol that uses a single anesthetic or barbiturate and overseen by qualified medical personnel, an expert panel has recommended.1

The report was prepared by the Death Penalty Committee of the Constitution Project, a non-partisan think tank that seeks to promote non-ideological policy solutions to problems involving rights guaranteed by the US Constitution.

In its work the committee, which comprises opponents and supporters of the death penalty, does not pass judgment on the use of capital punishment but seeks to identify systemic flaws in the administration of the death penalty and to make recommendations to correct them.

In addition to its recommendation on the use of lethal injections, the committee’s new report recommends changes such as ensuring adequate legal representation of defendants charged with capital crimes; prohibition of executions of people who have intellectual disabilities or who did not intentionally take the life of another; and …
Multiple significance tests
Authors: S. Voss, S. George
Journal: BMJ (1995)

EDITOR,—J Martin Bland and Douglas G Altman highlight the need, in significance testing, to take account of simultaneous tests that are not independent.1 This is a common situation in investigations of outbreaks of food poisoning. Such investigations usually take the form of a cohort or case-control study based on a questionnaire that contains questions about all, or as many as are known, of …
Perplexities in Cerebrovascular Disease
Authors: CLARK H. MILLIKAN
Journal: Annals of Internal Medicine (1963)

Editorials1 January 1963Perplexities in Cerebrovascular DiseaseCLARK H. MILLIKAN, M.D., F.A.C.P.CLARK H. MILLIKAN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-1-191 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFazekas, Alman, and Sullivan in their paper "Prognostic Uncertainties in Cerebral Vascular Disease," in this issue of the ANNALS, report data obtained in the careful clinical and laboratory investigation of 25 patients with aortocranial disease; 12 had arterial surgery while 13 did not, and all patients were treated with anticoagulants. Their observations exemplify a number of the complex unsolved problems that hamper the clinician in the diagnosis and treatment of occlusive cerebral vascular disease. Although intracranial or extracranial atherosclerosis of cerebral vessels (or both) appears to be the basic pathologic change associated with clinical findings of focal cerebral ischemia, severe... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Section of Neurology Mayo Clinic Rochester, Minnesota PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCerebrovascular Pathology and Pathogenesis as a Basis of Neuroradiological DiagnosisStenosierende und obliterierende zerebrale Gefäßprozesse 1 January 1963Volume 58, Issue 1Page: 191-192KeywordsAnticoagulantsAtherosclerosisCerebral ischemiaCerebrovascular diseasesClinical laboratoriesResearch designResearch laboratoriesVascular diseasesVascular surgery ePublished: 1 December 2008 Issue Published: 1 January 1963 PDF downloadLoading ...