Familial Benign Hypercalcemia
Authors: J. AUWERX
Journal: Annals of Internal Medicine (1985)

Letters and Corrections1 August 1985Familial Benign HypercalcemiaJ. AUWERX, M.D., R. BOUILLON, M.D., M. DEMEDTS, M.D.J. AUWERX, M.D.Search for more papers by this author, R. BOUILLON, M.D.Search for more papers by this author, M. DEMEDTS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-103-2-304_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Law and Heath (1) have compiled an important and extensive review of their experience with familial benign hypercalcemia. We want to comment on two problems in their review.First, although we agree that the parathyroid glands are not functioning autonomously in patients with familial benign hypercalcemia, we found in patients we examined an elevated "setpoint" of the parathyroid glands to extracellular calcium (2). In response to edetic-acid-induced hypocalcemia, our patients had an increase in the serum parathyroid hormone level that was intermediate between levels for healthy controls and patients with hyperparathyroidism due either to parathyroid hyperplasia or...References1. LAWHEATH WH. Familial benign hypercalcemia (hypocalciuric hypercalcemia): clinical and pathogenetic studies in 21 families. Ann Intern Med. 1985;102:511-9. LinkGoogle Scholar2. AUWERXDEMEDTSBOUILLON JMR. Altered parathyroid setpoint to calcium in familial hypocalciuric hypercalcemia. Acta Endocrinol. 1984;106:215-8. CrossrefMedlineGoogle Scholar3. AUWERXDEMEDTSBOUILLONDESMET JMRM. Coexistence of idiopathic pulmonary fibrosis and hypocalciuric hypercalcemia in a family: a cross-sectional study. Eur J Clin Invest. 1985;5:6-14. CrossrefGoogle Scholar4. DEMEDTSAUWERXGODDEERISBOUILLONGYSELENLAUWERIJNS MJPRAJ. The inherited association of interstitional lung disease hypocalciuric hypercalcemia and defective granulocyte function. Am Rev Respir Dis. 1985;131:470-5. MedlineGoogle Scholar5. AUWERXBOOGAERTSCEUPPENSDEMEDTS JMJM. Defective host defense mechanisms in a family with hypocalciuric hypercalcemia and co-existing interstitial lung disease. Clin Exp Immunol. (In press). Google Scholar1. LAWHEATH WH. Familial benign hypercalcemia (hypocalciuric hypercalcemia): clinical and pathogenetic studies in 21 families. Ann Intern Med. 1985;102:511-9. LinkGoogle Scholar2. HEATHPURNELL HD. Urinary cyclic 3′,5′-adenosine monophosphate responses to exogenous and endogenous parathyroid hormone in familial benign hypercalcemia and primary hyperparathyroidism. J Lab Clin Med. 1980;96:974-84. MedlineGoogle Scholar3. BROWNGARDNERBRENNAN EDM. Calcium-regulated parathyroid hormone release in primary hyperparathyroidism: studies in vitro with dispersed parathyroid cells. Am J Med. 1979;66:923-31. CrossrefMedlineGoogle Scholar4. AUWERXDEMEDTSBOUILLON JMR. Altered parathyroid setpoint to calcium in familial hypocalciuric hypercalcemia. Acta Endocrinol. 1984;106:215-8. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: J. AUWERX, M.D.; R. BOUILLON, M.D.; M. DEMEDTS, M.D.Affiliations: University Hospital Katholieke Universiteit Leuven B-3000 Leuven Belgium PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1985Volume 103, Issue 2Page: 304-305KeywordsCalciumHypercalcemiaHyperparathyroidismHypocalcemiaParathyroidParathyroid hormone ePublished: 1 December 2008 Issue Published: 1 August 1985 PDF downloadLoading ...