tbuckley/cabot-search huggingface dataset:
Pure red cell aplasia associated with angioimmunoblastic lymphadenopathy with dysproteinemia
Authors: James W. Lynch, Gerald J. Elfenbein, Ward D. Noyes, Raul C. Braylan, Mary Ann Gross, Roy S. Weiner
Journal: American Journal of Hematology (1994)

Abstract Angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) can best be described as a disorder of T‐cells resulting in amplification of the B‐cell response and clinical symptoms of lymphadenopathy, fever, hepatosplenomegaly, and a variety of blood abnormalities. Pure red cell aplasia (PRCA), an autoimmune disorder resulting in selective aplasia of the erythroid series, has only rarely been associated with AILD. Herein we report three cases of AILD and PRCA. Serum from one patient was available for study and contained a dose‐dependent inhibitor of the CFU‐E but not CFU‐GM cultures from normal bone marrow. This activity was found in the globulin fraction after ammonium sulfate precipitation. Patients with AILD are known to make antibodies to many autologous epitopes, and the most well‐characterized mechanism of PRCA involves antibodies to red cell precursors. Our serum data are consistent with the hypothesis that such an antibody existed in our patient. Aggressive treatment of these patients resulted in transient improvement in two; however, all three died without achieving a durable complete remission with two dying of infectious complications. © 1994 Wiley‐Liss, Inc.
Serum Uric Acid and Cardiovascular Disease Risk
Authors: Michael Poullis
Journal: Annals of Internal Medicine (2000)

Letters4 April 2000Serum Uric Acid and Cardiovascular Disease RiskMichael PoullisMichael PoullisHammersmith Hospital; East Acton, London, United Kingdom W12 ONN (Poullis)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-7-200004040-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The latest report from the Framingham Heart Study disputes the importance of serum uric acid with respect to cardiovascular disease (1).Diabetes, impaired renal function, and diuretics increase the serum uric acid level. These factors have confounded studies that reported an association between serum uric acid level and left ventricular function and cardiovascular morbidity and mortality.My colleagues and I analyzed 2729 patients undergoing cardiopulmonary bypass surgery. Patients who were diabetic, had a glomerular filtration rate less than 40 mL/min, or were receiving diuretics were excluded (n = 1567).We found that serum uric acid level was not related ...References1. Culleton BF, Larson MG, Kannel WB, Levy D. Serum uric acid and risk for cardiovascular disease and death: the Framingham Heart Study. Ann Intern Med. 1999;131:7-13. LinkGoogle Scholar2. Leyva F, Anker SD, Godsland IF, Teixeira M, Hellewell PG, Kox WJ, et al . Uric acid in chronic heart failure: a marker of chronic inflammation. Eur Heart J. 1998;19:1814-22. CrossrefMedlineGoogle Scholar3. Messent M, Sinclair DG, Quinlan GJ, Mumby SE, Gutteridge JM, Evans TW. Pulmonary vascular permeability after cardiopulmonary bypass and its relationship to oxidative stress. Crit Care Med. 1997;25:425-9. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Hammersmith Hospital; East Acton, London, United Kingdom W12 ONN (Poullis) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoSerum Uric Acid and Risk for Cardiovascular Disease and Death: The Framingham Heart Study Bruce F. Culleton , Martin G. Larson , William B. Kannel , and Daniel Levy Serum Uric Acid and Cardiovascular Disease Risk Michael H. Alderman Metrics Cited byRole of mangiferin on biochemical alterations and antioxidant status in isoproterenol-induced myocardial infarction in ratsSerum uric acid and risk of death from cancer, cardiovascular disease or all causes in men 4 April 2000Volume 132, Issue 7Page: 591-592KeywordsCardiopulmonary bypassDiureticsLongitudinal studiesMorbidityMortalityMyocardial infarctionPneumoniaRisk managementSurgeryUric acid Issue Published: 4 April 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Complement-Induced Granulocyte Aggregation
Authors: Howard L. Bleich, Mary Jean Moore, Harry S. Jacob, Philip R. Craddock, Dale E. Hammerschmidt, Charles F. Moldow
Journal: New England Journal of Medicine (1980)

The capacity of blood cells to aggregate, best exemplified by the response of platelets to vascular injury, is generally thought to be beneficial. However, if aggregation occurs inappropriately—that is, in a manner irrelevant to hemostasis — ischemic syndromes may result. The myocardial ischemia of Prinzmetal's angina pectoris, for example, may reflect platelet aggregation in coronary arteries. This article presents evidence that granulocytes as well as platelets can aggregate intravascularly, and that the resultant and previously unsuspected phenomenon of leukoembolization may underlie tissue damage in such diverse clinical situations as pulmonary dysfunction in hemodialyzed patients, sudden blindness with retinal infarction after . . .
Excision Margins in High-Risk Malignant Melanoma
Authors: J. Meirion Thomas, Julia Newton-Bishop, Roger A'Hern, Gill Coombes, Michael Timmons, Judy Evans, Martin Cook, Jeffery Theaker, Mary Fallowfield, Trevor O'Neill, Wlodek Ruka, Judith M. Bliss
Journal: New England Journal of Medicine (2004)

Controversy exists concerning the necessary margin of excision for cutaneous melanoma 2 mm or greater in thickness.
How Far Should a Physiatrist Go?
Authors: J. D. Keith Palmer
Journal: JAMA (1986)

<h3>To the Editor.—</h3> Dr E. A. Edwards,<sup>1</sup>in a Jan 17 book review, poses "a troubling question... how far the physiatrist should go in performing diagnostic tests such as electromyography, nerve conduction studies, or electrocardiography." A book review is not an appropriate forum to suggest curtailment of specialty professional privileges that have been developed, established, and recognized for over half a century. Physiatrists who conduct clinical diagnostic electroneuromyography (CDEMG) do so because they practice an integrative medical specialty, directed to investigating, evaluating, and extensively managing disorders affecting kinesis and personal adaptation to the pragmatic environment. Therefore, they have a special interest and training in CDEMG. An active four-year residency program in physiatry requires in its syllabus peripheral and central neurology, surface and kinesiologic anatomy, arthrology and myology, and much more, in an integrated and applied depth that, although included for other reasons, also leads to expertise in CDEMG. Because
Noncontraceptive Hormones and Rheumatoid Arthritis in Perimenopausal and Postmenopausal Women
Authors: Jan P. Vandenbroucke, Jacqueline C. M. Witteman, Hans A. Valkenburg, Johannes W. Boersma, Arnold Cats, Johannes J. M. Festen, Arend P. Hartman, Olga Huber-Bruning, Johannes J. Rasker, Jacobus Weber
Journal: JAMA (1986)

The use of noncontraceptive hormones before onset of joint disease was compared between 490 perimenopausal and postmenopausal women with rheumatoid arthritis and a control group of 659 women with soft-tissue rheumatologic disorders and/or osteoarthritis. Both groups were sampled randomly from the attendees of five rheumatologic clinics. A negative association was found between the onset of rheumatoid arthritis and the previous use of noncontraceptive hormones (odds ratio, 0.32; 95% confidence interval, 0.16 to 0.64). This association persisted on univariate and multivariate control of potentially confounding variables and on subgroup analysis. The protective effect of oral contraceptives on the development of rheumatoid arthritis was confirmed.
Finnish type of low density lipoprotein receptor gene mutation (FH-Helsinki) deletes exons encoding the carboxy-terminal part of the receptor and creates an internalization-defective phenotype.
Authors: K Aalto-Setälä, E Helve, P T Kovanen, K Kontula
Journal: Journal of Clinical Investigation (1989)

A specific type of gene mutation affecting the LDL receptor has been found in many Finnish patients with familial hypercholesterolemia (FH). The mutant allele is characterized by a 9.5-kb deletion extending from intron 15 to exon 18. Molecular cloning and sequencing of a cDNA segment corresponding to the deleted allele indicated that the mutant receptor differs radically from the normal one because of loss of the domains encoded by exons 16, 17, and 18. The carboxy-terminal portion of the normal receptor, comprising the amino acids 750-839, has been replaced by an unrelated stretch of 55 amino acids. The mutant allele was found to occur in 23 (50%) of 46 unrelated FH patients with an established functional defect in the LDL receptor. In cultured fibroblasts from the FH patients with the 9.5-kb deletion, both receptor-mediated binding and internalization of 125I-LDL were lower than normal, the former, on average, by 25%, and the latter, on average, by 50%. This combined functional defect probably results from both impaired attachment and impaired internalization of the mutated receptor. It remains to be investigated whether this Finnish type of LDL receptor gene mutation, here designated FH-Helsinki, occurs in other ethnic groups.
Lithium as an Adjuvant of lodine-131 Uptake when Treating Patients with Well-Differentiated Thyroid Carcinoma
Authors: F PONS, I CARRI??, M ESTORCH, M GINJAUME, J PONS, R MILIAN
Journal: Clinical Nuclear Medicine (1987)

Differences in the I-131 uptake by 14 metastatic lesions from well-differentiated thyroid carcinoma and 12 local remnants of normal thyroid tissue before and after an adjuvant therapy with lithium carbonate, were observed. After the adjuvant treatment and administration of an I-131 tracer dose, a considerable increase of radioiodine uptake in all metastatic lesions was found (P less than 0.001), but only a slight increase was found in 50% of the normal tissue. The response to lithium carbonate by neoplastic tissue seems to be different than that of the normal thyroid tissue, and produces a lengthening of the average I-131 biologic life that could be helpful when treating well-differentiated thyroid carcinoma.
Exposures to Airborne Particulate Matter and Adverse Perinatal Outcomes: A Biologically Plausible Mechanistic Framework for Exploring Potential Effect Modification by Nutrition
Authors: Srimathi Kannan, Dawn P Misra, J. Timothy Dvonch, Ambika Krishnakumar
Journal: Environmental Health Perspectives (2006)

The specific objectives are threefold: to describe the biologically plausible mechanistic pathways by which exposure to particulate matter (PM) may lead to the adverse perinatal outcomes of low birth weight (LBW), intrauterine growth retardation (IUGR), and preterm delivery (PTD); review the evidence showing that nutrition affects the biologic pathways; and explain the mechanisms by which nutrition may modify the impact of PM exposure on perinatal outcomes.We propose an interdisciplinary conceptual framework that brings together maternal and infant nutrition, air pollution exposure assessment, and cardiopulmonary and perinatal epidemiology. Five possible albeit not exclusive biologic mechanisms have been put forth in the emerging environmental sciences literature and provide corollaries for the proposed framework.Protecting the environmental health of mothers and infants remains a top global priority. The existing literature indicates that the effects of PM on LBW, PTD, and IUGR may manifest through the cardiovascular mechanisms of oxidative stress, inflammation, coagulation, endothelial function, and hemodynamic responses. PM exposure studies relating mechanistic pathways to perinatal outcomes should consider the likelihood that biologic responses and adverse birth outcomes may be derived from both PM and non-PM sources (e.g., nutrition). In the concluding section, we present strategies for empirically testing the proposed model and developing future research efforts.
Nitrazepam--a Safe Hypnotic
Authors: H. Matthew, A. T. Proudfoot, R. C. B. Aitken, J. A. Raeburn, N. Wright
Journal: BMJ (1969)

In 27 patients nitrazepam (Mogadon) taken in acute overdosage produced no untoward effects except drowsiness, even when 80 tablets were consumed. A double-blind trial in patients in general medical wards established that nitrazepam was as effective as butobarbitone as a hypnotic. It is concluded that nitrazepam is a safe and effective hypnotic.
Concealed reentry: a mechanism of atrioventricular nodal alternating Wenckebach periodicity.
Authors: L Littmann, R H Svenson
Journal: Circulation (1982)

Alternating WEnckebach periodicity is generally believed to reflect bilevel block due to horizontal electrophysiologic dissociation in the conducting tissues. We describe a case of atrial pacing-induced atrioventricular nodal alternating Wenckebach periodicity with concealed reentry in a longitudinally dissociated AV conduction system. Three observations support this unique mechanism: Concealed reentry occurred during the course of alternating Wenckebach periodicity; it could be invoked to explain the peculiar conduction patterns in this patient; and alternative mechanisms did not explain the alternating Wenckebach periods. Our findings also indicate that long conduction times during 2:1 block can be due to concealed reentry rather than concealed antegrade conduction, and participation in the echo process of a retrograde pathway with electrophysiologic characteristics of an atrioventricular nodal bypass tract does not exclude manifest and concealed reentry at a subatrial level.
Profibrotic agents for venous malformations?
Authors: L. Rittié
Journal: British Journal of Dermatology (2014)

Journal Article Profibrotic agents for venous malformations? Get access L. Rittié L. Rittié Department of Dermatology University of Michigan 6447 Medical Science Bldg. I, 1301 E. Catherine St Ann Arbor MI 48109 U.S.A Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 171, Issue 2, 1 August 2014, Pages 209–210, https://doi.org/10.1111/bjd.13164 Published: 01 August 2014
Junior Doctors Committee has achieved much recently
Authors: S. Smith
Journal: BMJ (1996)

EDITOR,—In his latest attack on the Junior Doctors Committee, Christopher Wong raises several points that deserve a reply.1 He vilifies the committee for inviting him to meetings where his views could have an influence on its policy. Oddly, he views this as the committee trying to shut him up. The reason he states for declining this invitation is that he attended such meetings “a few years ago,” found them unrepresentative of his views, and decided to boycott …
Hepatitis C infection in two urban hemodialysis units
Authors: Lennox J. Jeffers, Guido O. Perez, Maria D. de Medina, Carmen J. Ortiz-Interian, Eugene R. Schiff, K. Rajender Reddy, Margarita Jimenez, Jacques J. Bourgoignie, Carlos A. Vaamonde, Robert Duncan, Michael Houghton, George-Lim Choo, George Kuo
Journal: Kidney International (1990)

We determined the prevalence of antibodies to the hepatitis C virus (anti-HCV) in 90 patients and 37 staff members of two hemodialysis units utilizing a recently developed anti-HCV recombinant based assay. Eleven patients (12%) were anti-HCV(+). Of these, eight (73%) had antibodies to the hepatitis B core antigen (anti-HBc) indicating prior hepatitis B infection; one patient was hepatitis B surface antigen (HBsAg)(+). All staff members were anti-HCV(-), although seven (19%) of them were anti-HBc(+). Alanine aminotransferase elevations were present at the time of the study in four anti-HCV(-) patients and in only one anti-HCV(+) patient. All anti-HCV(+) (mean 59 +/- 74; range 3 to 269 units) and 85% of anti-HCV(-) patients (mean 16 +/- 27; range 0 to 204 units) had received multiple blood transfusions (P = 0.348). Among 50 patients tested for human immunodeficiency virus (HIV), 43% of anti-HCV(+) as compared to only 7% anti-HCV(-) were positive (P = 0.003). There was a history of intravenous drug abuse (IVDA) in eight (72%) of the anti-HCV(+) patients and in only seven (9%) of the anti-HCV(-) group (P = 0.00001). The results of this serologic survey suggests that anti-HCV positivity is prevalent, although much less than anti-HBc, among our dialysis patients, whereas it was not detected among staff members. The prevalence rate of anti-HCV was statistically significantly higher among anti-HIV(+) and IVDA patients but not in multi-transfused patients.
Serum concentrations of IL‐5, GM‐CSF, and IL‐3 and the production by lymphocytes in various eosinophilia
Authors: Toshiyuki Koike, Hideo Enokihara, Hironari Arimura, Haruhiko Ninomiya, Kyoko Yamashiro, Nobuo Tsuruoka, Masafumi Tsujimoto, Masakuni Aoyagi, Kanji Watanabe, Yuuichi Nakamura, Kenji Saitou, Shimpei Furusawa, Hideo Shishido
Journal: American Journal of Hematology (1995)

The concentrations of interleukin-5 (IL-5), granulocyte-macrophage colony-stimulating factor GM-CSF, and interleukin-3 (IL-3) in serum and in IL-2-stimulated lymphocyte culture medium (L-IL2-CM) prepared from patients with reactive eosinophilia were measured by enzyme-linked immunosorbent assay (ELISA). Serum IL-5 levels were increased in 16 out of 42 cases. GM-CSF and IL-3 were below the detectable levels in all sera examined. The concentrations of IL-5 and GM-CSF in L-IL2-CM were increased in 10 out of 29 patients. IL-3 was below the detectable levels in all L-IL2-CM.
A functional extracellular matrix biomaterial derived from ovine forestomach
Authors: Stan Lun, Sharleen M. Irvine, Keryn D. Johnson, Neil J. Fisher, Evan W. Floden, Leonardo Negron, Sandi G. Dempsey, Rene J. McLaughlin, Madhusudan Vasudevamurthy, Brian R. Ward, Barnaby C.H. May
Journal: Biomaterials (2010)
Poliomyelitis Simulating Tetanus
Authors: S. Manners
Journal: BMJ (1955)

BEMSH 27On February 3 laparotomy was performed.On palpation of the uterus no foetal parts were felt.The uterus was opened through a lower segment incision, and was found to contain a large hydatidiform mole.The uterine cavity was evacuated completely.Both ovaries contained multiple theca lutein cysts.These were left in situ.The patient made good progress, and the post-operative period was uneventful.She was discharged on the 17th day after operation.The Aschlteim-Zondek test, repeated on the 12th post-operative day, was positive undiluted, but negative in all dilutions.It is unusual to find the Aschheim-Zondek test positive in such high dilutions as described in this case, and very careful follow-up of this patient with quantitative Aschheim-Zondek tests done at regular intervals will be necessary for at least two years.My thanks are due to Mr. Anthony C.
The Relationship of Menstrual Cycle and Pregnancy to Compulsive Hairpulling
Authors: Nancy J. Keuthen, Richard L. O’Sullivan, Caroline F. Hayday, Kathleen E. Peets, Michael A. Jenike, Lee Baer
Journal: Psychotherapy and Psychosomatics (1997)

Background: Trichotillomania (TTM) or compulsive hairpulling is a cyclical disorder that presents predominantly in females. Anecdotal reports of symptom worsening in the premenstruum and during pregnancy led us to retrospectively study the role of these events in hairpulling behavior. Methods: Questionnaires assessing demographics, current hairpulling behavior, and the reported effects of menstruation and pregnancy on urges, actual hairpulling and behavioral control were administered to clinic patients and volunteers at a hairpulling conference. The MGH Hairpulling Scale, Beck Depression Inventory and Beck Anxiety Inventory were also completed. Data from 59 hairpull-ers were analyzed. Results: Premenstrual symptom exacerbation was reported for actual hairpulling, urge intensity and frequency, and ability to control pulling and was alleviated during menstruation and shortly thereafter. The impact of pregnancy was less unidirectional, with both symptom exacerbation and lessening reported. Conclusions: The menstrual cycle appears to affect compulsive hairpulling and deserves recognition in both the assessment and treatment of this disorder. The impact of pregnancy on TTM is less clear.
Improvement in renal function and its impact on survival in patients with newly diagnosed multiple myeloma
Authors: W I Gonsalves, N Leung, S V Rajkumar, A Dispenzieri, M Q Lacy, S R Hayman, F K Buadi, D Dingli, P Kapoor, R S Go, Y Lin, S J Russell, J A Lust, S Zeldenrust, R A Kyle, M A Gertz, S K Kumar
Journal: Blood Cancer Journal (2015)

Abstract Renal impairment (RI) is seen in over a quarter of patients with newly diagnosed multiple myeloma (NDMM). It is not clear if reversal of RI improves the outcome to that expected for NDMM patients without RI. We evaluated 1135 consecutive patients with NDMM seen at the Mayo Clinic between January 2003 and December 2012. RI was defined as having a creatinine clearance (CrCl) &lt;40ml/min. The median overall survival (OS) for patients with RI at diagnosis receiving and not receiving novel agent induction therapy was not reached vs 46 months ( P &lt;0.001). The median OS for patients with CrCl ⩾40 ml/min at diagnosis, CrCl &lt;40 ml/min at diagnosis but improved to ⩾40 ml/min and CrCl &lt;40 ml/min at diagnosis and remained &lt;40 ml/min, were 112, 56 and 33 months, respectively ( P &lt;0.001). The complete renal response rate for patients with RI at diagnosis receiving novel agent induction therapy compared to the rest was 40 vs 16% ( P &lt;0.001). In conclusion, patients with reversal of RI have improved outcomes, but it remains inferior to patients with normal renal function at diagnosis. These results have implications for identifying early treatment strategies for patients at risk of developing renal insufficiency.
The Unwanted Pregnancy
Authors: R. Bruce Sloane
Journal: New England Journal of Medicine (1969)

Abstract There are no clear-cut psychiatric indications for therapeutic abortion. The risk of precipitation or exacerbation of an existing psychosis is small and unpredictable, and suicide is rare. "Humanitarian" reasons frequently determine the decision although they may masquerade under psychiatric labels. Little new psychiatric illness appears after therapeutic abortion that can be related to the procedure. Women who seek abortion, for whatever reason, may prove unsatisfactory mothers if forced to carry their pregnancy to term. Their emotional symptoms may subside more quickly if they are granted their wish. Any change in the abortion law should include a "social clause" such as that promulgated in Britain. This recognizes the risk of an unwanted pregnancy to the physical and mental health of the existing children and allows consideration of overcrowding and strain on the mother. Such a change would facilitate a more candid appraisal of the problem as a therapeutic rather than medicolegal one.
TCT-637 Analysis of Quality of Life Decrements Associated with Changes in Angina Status in the ABSORB II Trial: First Randomized Comparison Between the Absorb™ Everolimus Eluting Bioresorbable Vascular Scaffold and the XIENCE™ Everolimus Eluting Stent
Authors: Bernard Chevalier, Patrick W. Serruys, Roseann M. White, Mindy M. Cheng, Leslie Stephens, John B. Hernandez
Journal: Journal of the American College of Cardiology (2014)