Cimetidine and Agranulocytosis
Authors: STEPHEN A. KLOTZ
Journal: Annals of Internal Medicine (1978)

Letters and Corrections1 April 1978Cimetidine and AgranulocytosisSTEPHEN A. KLOTZ, M.D., BILLY F. KAY, M.D.STEPHEN A. KLOTZ, M.D.Search for more papers by this author, BILLY F. KAY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-88-4-579_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The following two case histories describe apparent adverse reactions to the histamine H2-receptor antagonist cimetidine (Tagamet®).A 62-year-old woman with a complicated medical history that included an autoimmune thrombocytopenia (with antiplatelet antibodies) and arthritis and pleural effusion (with the absence of antinuclear antibodies, rheumatoid factor, or lupus erythematosus cell phenomenon) had been taking cimetidine, 300 mg four times daily for 1 month, for endoscopically proven severe antral gastritis and a bezoar. Concurrent medications included hydrochlorothiazide, 50 mg every day; propranolol, 20 mg three times daily; Synthroid®, 0.1 mg every day; and prednisone, 10 and 5 mg on...References1. FORREST J, SHEARMAN D, SPENCE R, and CELESTIN L: Neutropenia associated with metiamide (letter). Lancet 1:392-393, 1975 CrossrefMedlineGoogle Scholar2. ROBINSON T and MULLIGAN T: Cimetidine and mental confusion. Lancet 2:719, 1977 CrossrefMedlineGoogle Scholar3. MENZIES-GOW N: Cimetidine and mental confusion. Lancet 2:928, 1977 CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: STEPHEN A. KLOTZ, M.D.; BILLY F. KAY, M.D.Affiliations: Olathe Community Hospital Olathe, KS 66061 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIs cimetidine associated with neutropenia?Histamine-induced leukocytosisCentral Nervous System Reactions to Histamine-2 Receptor BlockersThomas G. Cantú, PharmD, Joan S. Korek, PharmDHistamine and the BloodHaematological Adverse Effects of Histamine H2-Receptor AntagonistsBone Marrow Hypoplasia During Intensive Care: Bone Marrow Culture Studies Implicating Ranitidine in the Suppression of HaemopoiesisBone Marrow Toxicity of Antitumor AgentsCimetidine suppression of CFU-C in malesEffect of cimetidine on granulocyte-macrophage colony formation by normal and chronic renal failure bone marrow cellsDistribution of Cimetidine in Postmortem TissuesCase Report: Cimetidine-Associated Depression and Loss of Libido in a WomanSide Effects of Histamine2-Receptor AntagonistsReview of Cimetidine Drug InteractionsGastrointestinal DrugsNeurological and psychiatric side effects of cimetidine—report of 3 cases with review of the literatureCimetidine and prolonged post-operative somnolenceFATAL AGRANULOCYTOSIS ATTRIBUTABLE TO CIMETIDINEA consideration of the adverse effects of cimetidineCimetidine and hematologic suppressionCimetidine Impairs Elimination of Chlordiazepoxide (Librium) in ManPAUL V. DESMOND, M.B., B.S., RASHMI V. PATWARDHAN, M.D., STEVEN SCHENKER, M.D., K. V. SPEEG Jr., M.D., Ph.D.Severe Granulocytopenia with Cimetidine and PhenytoinELIZABETH SAZIE, M.D., JEFFRY P. JAFFE, M.D.Cimetidine-induced bone marrow suppressionEffect of Cimetidine and other antihistaminics on the elimination of aminopyrine, phenacetin and caffeinANTACIDS AND CRICOID PRESSURE IN PREVENTION OF FATAL ASPIRATION SYNDROMEAUTOIMMUNE HÆMOLYTIC ANÆMIA ASSOCIATED WITH CIMETIDINECimetidine and AgranulocytosisFIRAS H. AL-KAWAS, M.D., BRUCE A. LENES, M.D., RONALD A. SACHER, M.D.Cimetidine and GranulocytopeniaJAMES W. FRESTON, M.D.Pancytopenia with CimetidineC. DE GALOCSY, M.D., C. VAN YPERSELE DE STRIHOU, M.D.PHARMACOKINETIC AND CLINICAL STUDIES IN PATIENTS WITH CIMETIDINE-ASSOCIATED MENTAL CONFUSIONAntihistaminesCimetidine: Safety and Side-EffectsBone-Marrow Depression with Cimetidine plus Carmustine 1 April 1978Volume 88, Issue 4Page: 579-580KeywordsAdverse reactionsAntinuclear antibodiesAntiplatelet antibodiesGastritisHistamineIdiopathic thrombocytopenic purpuraLupus erythematosusPleural effusionRheumatoid arthritis ePublished: 1 December 2008 Issue Published: 1 April 1978 PDF downloadLoading ...