tbuckley/cabot-search huggingface dataset:
"Normothermic range" temperature affects myocardial infarct size
Authors: G. L Chien, R. A Wolff, R. F Davis, D. M V. Winkle
Journal: Cardiovascular Research (1994)

This study tested the hypothesis that small changes in temperature above the hypothermic range may alter myocardial infarct size after acute coronary occlusion-reperfusion. A secondary hypothesis, that a correlation between temperature and infarct size may be independent of an associated change of heart rate, was also evaluated.Eighteen pentobarbitone-anaesthetised, open chest rabbits underwent 30 min coronary artery occlusion and 3 h reperfusion at blood temperatures ranging from 35-42 degrees C, achieved and maintained using surface methods (not paced, group NP). In a second group of 11 animals, heart rate was held constant across the same range of temperatures (paced, group P), before and throughout coronary artery occlusion-reperfusion. Infarct sizes were assessed by the tetrazolium method.Target temperature was effectively controlled over the duration of the experimental protocol to within +/- 0.25 degrees C. Area at risk did not vary with temperature. Infarct size, normalised to area at risk, was correlated with temperature in both groups (infarct size = 7.9 x temp-250.0, r = 0.75, p = 0.0003, group NP; infarct size = 11.7 x temp-404.5, r = 0.88, p = 0.0004, group P). There was no significant difference between the slopes of these two lines (p = 0.18), indicating that the positive correlation between infarct size and temperature is not related to changes of heart rate.Temperatures in the range of 35-42 degrees C affect myocardial infarct size significantly, independent of heart rate.
Effect of AA‐861, a 5‐Lipoxygenase Inhibitor, on Leukotriene Synthesis in Human Polymorphonuclear Leukocytes and on Cyclooxygenase and 12‐Lipoxygenase Activities in Human Platelets
Authors: H. Mita, Y. Yui, T. Shida
Journal: Allergy (1986)

AA-861, a selective inhibitor of 5-lipoxygenase of arachidonic acid, was tested for ability to inhibit leukotriene C4 and leukotriene B4 synthesis in human polymorphonuclear leukocytes after calcium ionophore stimulation. AA-861 dose-dependently inhibited leukotriene B4 and leukotriene C4 generation in human polymorphonuclear leukocytes; the concentration required to inhibit generation by 50% (IC50) was 3 X 10(-7) M for leukotriene B4 and 1 X 10(-8) M for leukotriene C4. BW-755C inhibited the generation of leukotriene C4 with an IC50 of about 10(-5) M, indicating that AA-861 is about 1,000 times more potent than BW-755C. AA-861 did not affect the activity of either cyclooxygenase or 12-lipoxygenase at a concentration up to 10(-5) M in human platelets. AA-861 did not inhibit histamine release from human basophils. These results indicate that AA-861 selectively inhibits 5-lipoxygenase but not cyclooxygenase or 12-lipoxygenase in human specimens.
Genome integrity of myeloproliferative neoplasms in chronic phase and during disease progression
Authors: Thorsten Klampfl, Ashot Harutyunyan, Tiina Berg, Bettina Gisslinger, Martin Schalling, Klaudia Bagienski, Damla Olcaydu, Francesco Passamonti, Elisa Rumi, Daniela Pietra, Roland Jäger, Lisa Pieri, Paola Guglielmelli, Ilaria Iacobucci, Giovanni Martinelli, Mario Cazzola, Alessandro M. Vannucchi, Heinz Gisslinger, Robert Kralovics
Journal: Blood (2011)
Epicutaneous Immunotherapy Induces Epigenetic Changes In Sensitized Mice
Authors: Lucie Mondoulet, Vincent Dioszeghy, Mélanie Ligouis, Véronique Dhelft, Emilie Puteaux, Camille Plaquet, Christophe Dupont, Pierre Henri Benhamou
Journal: Journal of Allergy and Clinical Immunology (2014)
Lesions are seen in young users of stimulant drugs
Authors: D. M. Fatovich, D. McCoubrie, S. Song, N. Lawn, F. Daly
Journal: BMJ (2010)

The editorial by Wallin and Fladby highlights the clinical importance of white matter hyperintensities on magnetic resonance imaging as a marker of small vessel disease in elderly people.1 Prevalence ranges from 11-21% at age 64 …
Autonomous psychology and the moderate neuron doctrine
Authors: Tony Stone, Martin Davies
Journal: Behavioral and Brain Sciences (1999)

Two notions of autonomy are distinguished. The respective denials that psychology is autonomous from neurobiology are neuron doctrines, moderate and radical. According to the moderate neuron doctrine, interdisciplinary interaction need not aim at reduction. It is proposed that it is more plausible that there is slippage from the moderate to the radical neuron doctrine than that there is confusion between the radical neuron doctrine and the trivial version.
Prevention of some hypothermia induced electromechanical changes by calcium channel blockade
Authors: H. Bjornstad, D. A Lathrop, H. Refsum
Journal: Cardiovascular Research (1994)

Objective: Cooling induces electromechanical changes in the heart. The aim of the study was to examine how the calcium channel blocker, nisoldipine (NIS), altered these changes compared to those induced by other drugs that shorten action potential duration such as tetrodotoxin and nicorandil. Methods: Guinea pig papillary muscle action potentials and developed force were recorded using the conventional microelectrode technique and a force transducer. Restitution of action potential duration was determined by introducing extrastimuli at progressively longer diastolic intervals from 40 to 9000 ms. Preparations were divided into four groups: (1) no drug (control); (2) 1 μM tetrodotoxin, a sodium channel blocker; (3) 1 mM nicorandil, an ATP sensitive potassium channel activator; and (4) 1 μM nisoldipine (n = 6 in each group). Action potential duration and developed force were recorded after addition of drug at 37°C, and at each 1°C change in temperature during cooling to 27°C. The restitution protocol was performed at 37° and 27°C. Results: Tetrodotoxin had no effect on action potential duration at 90% of repolarisation (APD90) while nisoldipine and nicorandil greatly shortened APD90. Cooling from 37° to 27°C with nisoldipine produced less hypothermia induced lengthening in APD90 than in the other group. Developed force did not increase with reduction in temperature in the presence of nisoldipine. The range of premature action potential durations was defined as the difference in APD90 at diastolic interval of 40 and 100 ms. This range decreased with nisoldipine in contrast to the marked increases that occurred in the other groups during cooling. Conclusions: Increased intracellular Ca2+ might be responsible for the hypothermia induced increase in APD90, developed force, and range of premature action potential durations, since calcium channel blockade, which prevents an increase in intracellular Ca2+, greatly reduced these changes. The reduced range of premature action potential durations may reduce dispersion of ventricular refractoriness, and hence be expected to decrease hypothermia induced arrhythmias. Cardiovascular Research 1994;28:55-60
Recurrent Infection of the Urinary Tract: Reinfection or Recrudescence?
Authors: J. McGeachie
Journal: BMJ (1966)

JOURNALadhering strictly to the diet and 2.6 lb.(1.18 kg.) in those deviating from it.The five meals a day diet was acceptable to many patients with " refractory obesity," but the results were satisfactory only in those who adhered strictly to the diet.We wish to thank Miss E. M. Wilson for preparing the diets and for assistance with the study.
Exposure to Mouse Allergen in U.S. Homes Associated with Asthma Symptoms
Authors: Päivi M. Salo, Renee Jaramillo, Richard D. Cohn, Stephanie J. London, Darryl C. Zeldin
Journal: Environmental Health Perspectives (2008)

Most studies investigating the role of residential mouse allergen exposures in asthma have focused on inner-city populations.We examined whether elevated mouse allergen levels were associated with occupants' asthma status in a nationally representative sample of U.S. households.Data for this study were collected as part of the National Survey of Lead and Allergens in Housing. This cross-sectional study surveyed 831 housing units inhabited by 2,456 individuals in 75 different locations throughout the United States. The survey obtained information on demographics, household characteristics, and occupants' health status by questionnaire and environmental observations. We used a polyclonal immunoassay to assess concentrations of mouse urinary protein (MUP) in vacuumed dust collected from various indoor sites.Of the surveyed homes, 82% had detectable levels of MUP, and in 35% of the homes, MUP concentrations exceeded 1.6 microg/g, a level that has been associated with increased mouse allergen sensitization rates. Current asthma, defined as having doctor-diagnosed asthma and asthma symptoms in the preceding 12 months, was positively associated with increased MUP levels. The observed association was modified by atopic status; in allergic individuals, elevated MUP levels (>1.6 microg/g) increased the odds of having asthma symptoms [adjusted OR=1.93; 95% confidence interval (CI), 1.14-3.27], but we found no association in those who did not report allergies (adjusted OR=0.69; 95% CI, 0.33-1.44).In allergic asthma, residential mouse allergen exposure is an important risk factor for asthma morbidity.
1120-66 Early saphenous vein graft failure: A predictor of poor outcomes after percutaneous coronary intervention
Authors: Daniel Arthur Canos, Gary S Mintz, Ben Y Rock, Esteban Escolar, Natalie Gevorkian, Augusto D Pichard, Lowell F Satler, Kenneth M Kent, Neil J Weissman
Journal: Journal of the American College of Cardiology (2004)
Accident department or general practice?
Authors: T Davies
Journal: BMJ (1986)

Ninety two patients, who were registered with one general practice partnership that has a tradition of providing minor trauma services and who had attended a hospital accident and emergency department, completed a questionnaire giving their reasons for not first attending their general practitioners with their ailments. Most had not tried to contact their general practitioner, and of these, only a few were unsuitable for treatment first by the general practitioner. More than half had attended the accident and emergency department because they did not want to bother their own general practitioner or thought that their problem was unsuitable for his attention. A higher proportion had attended for reasons of perceived speed or convenience. In the light of the need to cut costs in the hospital service and of government interest in promoting a wider range of services in general practice further study of such problems is needed. Patients' perceptions of the role of the accident department need to be changed if present behaviour is to be altered.
Heart Failure Complicating Acute Myocardial Infarction
Authors: MICHAEL J. WOLK, STEPHEN SCHEIDT, THOMAS KILLIP
Journal: Circulation (1972)

Congestive heart failure (CHF) occurs in about one half of all patients with acute myocardial infarction and is a manifestation of acute alterations in left ventricular function. In the present study CHF is defined on clinical grounds, according to the presence and extent of bilateral pulmonary rales. An accompanying S 3 ventricular gallop was heard in 58% of our patients with heart failure initially, but it disappeared eventually in the majority. Dilatation of pulmonary veins and blurring of pulmonary vascular markings are useful roentgenographic signs which reflect elevations in left heart filling pressure. At times the earliest indicators of heart failure, these findings appear in general to be less sensitive than the physical examination in diagnosing CHF. Although stroke volume is decreased with CHF, cardiac index is generally maintained by increased heart rate. Left ventricular minute work and stroke work are significantly decreased, while left ventricular end-diastolic pressure is significantly increased, in patients with CHF complicating acute myocardial infarction. Arterial hypoxemia is common and the degree of arteriovenous shunting is roughly proportional to the elevation of left ventricular filling pressure. The mortality of patients with CHF is approximately three times that of patients with acute myocardial infarction and no complications. Diuretic therapy is safe and effective. Attention is called to the probability that the use of digitalis preparations in the early hours following myocardial infarction is hazardous. Furthermore, hemodynamic benefit from digitalization in the early postinfarction period remains unproven.
Crohn's disease in the elderly.
Authors: P J Fabricius, S N Gyde, P Shouler, M R Keighley, J Alexander-Williams, R N Allan
Journal: Gut (1985)

The natural history of Crohn9s disease in 47 patients, 60 years of age or older at the time of diagnosis has been defined, and their clinical management and long term prognosis reviewed. Distal colonic involvement is common in this group while extensive colonic and diffuse small bowel disease is rare. Distal colonic involvement usually carries a good prognosis except for those few patients who present with perforation which accounts for most of the disease related mortality. The pattern of distal ileal disease is similar to that observed in the younger patients except for the acute nature of symptoms at first presentation, and the low recurrence rates after initial surgical resection.
THE RELATIVE REACTION WITHIN LIVING MAMMALIAN TISSUES
Authors: D. R. Drury, W. W. Beattie, Peyton Rous
Journal: The Journal of Experimental Medicine (1927)

Breathing an atmosphere that contains the normal amount of oxygen but a large excess of carbon dioxide results in a tissue acidosis as well as one of the blood. The extravascular changes in reaction take place with far greater speed than when acidosis is induced with hydrochloric acid, and they do not persist as in the case of this latter but swiftly disappear when the animal breathes ordinary air once again. The changes parallel closely in magnitude and time those occurring in the blood. The same matrix tissues are rendered acidotic is when hydrochloric acid is administered. The blood alkalosis that results from a blowing off of carbon dioxide is accompanied by an extravascular alkalosis. Under the circumstances of our experiments the connective tissue became more alkaline than ordinary but no change was noted in the cartilage, a fact to be explained by the slight degree of the alkalosis and its brief duration.
996 HUMAN POLYCYSTIC LIVER CYST FLUID INDUCED CHOLANGIOCYTE PROLIFERATION IS REVERSED BY LANREOTIDE IN A SOMATOSTATIN RECEPTOR 5 AND PHOSPHODIESTERASE 4D DEPENDENT MECHANISM
Authors: J. Woudenberg, M.J. Janssen, I. Worm, R.H. Te Morsche, M. Chrispijn, J.P.H. Drenth
Journal: Journal of Hepatology (2010)
A CONTRIBUTION TO THE STUDY OF VISUAL DISTURBANCES IN BRAIN INJURY.
Authors: WILLIAM E. GAMBLE
Journal: JAMA (1904)

country and in the great work of organization, with not more than two exceptions, the spirit of compromise has been so dominant that prejudices, predilections, preroga¬ tives and even minor principles have been willingly and gladly subordinated to the greater principles for the conservation of the greater good.This spirit•-the very soul of fraternity, coupled with the spirit of industry, the spirit of culture, the spirit of patriotism-must be kept in the ascendant if we, as a profession, shall main¬ tain our just position and discharge our full duty as citizens of this great republic.
The Pre-disaster Syndrome
Authors: J. C. Barker
Journal: JAMA (1967)

<h3>To the Editor:—</h3> On Friday, Oct 21, 1966, at 9:15 AM, a massive coal-tip slid down a mountainside onto the Welsh mining village of Aberfan, destroying several houses and part of the school. One hundred and sixteen children and 28 adults were killed, the majority being buried alive in black mud and slurry. I visited Aberfan the following day and was appalled by the devastation and human suffering. Being interested in precognition, it occurred to me that there might be many people in Britain and possibly elsewhere who had experienced some forewarning of a tragedy of such magnitude. I therefore appealed through the national press for persons claiming any foreknowledge of this disaster to send me details of their experiences. I received 76 letters in response, some 60 of which required further investigation. Twenty-two of the accounts have since been verified as being reported to others before the disaster occurred
Cluster-randomized trial of a mobile phone personalized behavioral intervention for blood glucose control. Diabetes Care 2011;34:1934–1942
Authors: CC Quinn, MD Shardell, ML Terrin, EA Barr, SH Ballew, AL Gruber-Baldini
Journal: Diabetes Care (2013)

Quinn CC, Shardell MD, Terrin ML, Barr EA, Ballew SH, Gruber-Baldini AL. Cluster-randomized trial of a mobile phone personalized behavioral intervention for blood glucose control. Diabetes Care 2011;34:1934–1942 

In the article listed above, the values for the 9-month glycated hemoglobins are incorrect due to a programming error. The significance of the results and the discussion remained unchanged. The changes to Table 1 and to the text are detailed below.
Does Asymptomatic Bacteriuria Predict Mortality and Does Antimicrobial Treatment Reduce Mortality in Elderly Ambulatory Women?
Authors: Elias Abrutyn
Journal: Annals of Internal Medicine (1994)

Objective: To determine whether asymptomatic bacteriuria in elderly ambulatory women is a marker of increased mortality and, if so, whether it is because of an association with other determinants of mortality or because asymptomatic bacteriuria is itself an independent cause, the removal of which might improve longevity. Design: A cohort study and a controlled clinical trial of the effect of antimicrobial treatment. Setting: A geriatric center and 21 continuing care retirement communities. Participants: Women without urinary tract catheters. Measurements: Urine cultures every 6 months (the same organism at 105 colony-forming units or more per mL on two midstream urine specimens defined asymptomatic bacteriuria), comorbidity, and mortality. Results: In the observational study, infected residents (n = 318) were older, and sicker, and had higher mortality (18.7 per 100 000 resident-days) than uninfected residents (n = 1173; 10.1 per 100 000 resident-days). However, in a multivariate Cox analysis, infection was not related to mortality (relative risk, 1.1; P > 0.2), whereas age at entry and self-rated health (score 1 [excellent] to 4 [bad or poor]) were strong predictors. In the clinical trial, mortality in 166 treated residents (13.8 per 100 000 resident-days) was comparable to that of 192 untreated residents (15.1 per 100 000 resident-days); the relative rate was 0.92 (95% CI, 0.57 to 1.47). The cure rates among treated and untreated residents were 82.9% and 15.6%, respectively. Conclusion: Urinary tract infection was not an independent risk factor for mortality, and its treatment did not lower the mortality rate. Screening and treatment of asymptomatic bacteriuria in ambulatory elderly women to decrease mortality do not appear warranted.
Experimental aortic valve heterotransplantation
Authors: C. G. Duran, A. J. Gunning, R. Whitehead
Journal: Thorax (1967)

Pig aortic valves were transplanted into the descending aorta of 41 dogs. Ficin-digested valve grafts and fresh untreated grafts were associated with poor results and extremely short survival of the recipient animals. When freeze-dried valves were transplanted the mortality was reduced and the survival time increased, but there was a marked tendency for the grafts to rupture through the heterologous aortic wall cuff. If a homologous aortic cuff was used the survival time was increased, but rupture through the aortic wall cuff still occurred. The freeze-dried valve grafts eventually became almost acellular. Thrombus, which was commonly present on the valves, rarely showed organization. The valve cusps tended to remain thin and delicate, in one dog for as long as eight months after operation.
Apolipoprotein AI– and AI:AII—containing lipoproteins in white men and women of the HERITAGE Family study: associations with metabolic risk profile variables
Authors: Charles Couillard, Jean Bergeron, Jean-Pierre Després, Jacques Gagnon, Tuomo Rankinen, Arthur S Leon, D.C Rao, James S Skinner, Jack H Wilmore, Claude Bouchard
Journal: Metabolism (2003)
Complete Transposition of the Great Arteries
Authors: Maria Cristina Digilio, Brett Casey, Alessandra Toscano, Raffaele Calabrò, Giuseppe Pacileo, Maurizio Marasini, Elena Banaudi, Aldo Giannotti, Bruno Dallapiccola, Bruno Marino
Journal: Circulation (2001)

Transposition of the great arteries (TGA) is considered to be associated only rarely with genetic syndromes and to have a low risk of precurrence among relatives of affected patients. Because most family studies have involved a relatively small number of patients and evaluated all types of TGA as a single group, we performed a large, prospective study investigating the precurrence of congenital heart disease in families of children with complete, nonsyndromic TGA.From January 1997 through December 2000, 370 patients with nonsyndromic, complete TGA were consecutively evaluated and enrolled in the study. The occurrence of cardiac and noncardiac anomalies among relatives of the probands was investigated. Relatives with congenital heart disease were found in 37 of 370 families (10%), including 5 of 37 families (13.5%) with more than one affected relative. TGA itself was the most common precurrent malformation: complete TGA occurred in 6 families and congenitally corrected TGA occurred in 5 families. Precurrence risks for congenital heart disease were calculated at 1.8% (8 of 436) for siblings, 0.5% (4 of 740) for parents, 0.5% (16 of 3261) for first cousins, 0.2% (4 of 2101) for uncles/aunts, and 0.06% (1 of 1480) for grandparents.The present study shows that TGA is not always sporadic in families. Precurrence of concordant cardiac defects within affected family members supports monogenic or oligogenic inheritance of TGA in certain kindreds. Moreover, the occurrence of complete TGA and congenitally corrected TGA among first-degree relatives in several different families strongly suggests an underlying pathogenetic link between these 2 malformations that has been previously unrecognized.
Evaluation of dithranol and a 'synthetic tar' as anti-psoriatic treatments using the mouse tail test
Authors: ROSANNE WRENCH, ADAM Z.BRITTEN
Journal: British Journal of Dermatology (1975)

Journal Article Evaluation of dithranol and a 'synthetic tar' as anti‐psoriatic treatments using the mouse tail test Get access ROSANNE WRENCH, ROSANNE WRENCH Department of Pharmacy, University of Aston in Birmingham, B4 7ET *Address for correspondence: Dr Rosanne Wrench, Flat 40, Pitmaston Court, Goodby Road, Birmingham, B13 8RL. Search for other works by this author on: Oxford Academic Google Scholar ADAM Z.BRITTEN ADAM Z.BRITTEN Department of Pharmacy, University of Aston in Birmingham, B4 7ET Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 93, Issue 1, 1 July 1975, Pages 75–78, https://doi.org/10.1111/j.1365-2133.1975.tb06479.x Published: 01 July 1975
Overcoming Resistance to Targeted Anticancer Drugs
Authors: James H. Doroshow
Journal: New England Journal of Medicine (2013)

More than a decade ago, imatinib, an agent that has a specific inhibitory interaction with the BCR-ABL fusion protein, was introduced for the treatment of chronic myeloid leukemia (CML). The introduction of this agent dramatically changed researchers' understanding not only of the role of tyrosine kinases as targets for oncology drugs (despite the conserved status of protein kinase domains in nature), but also their ability to conceptualize and test novel molecular mechanisms of action and drug resistance in solid tumors such as adenocarcinoma of the lung as well as in hematopoietic cancers.1,2 The underlying genetic instability of most cancers . . .