Captopril and Enalapril
Authors: JONATHAN K. WILKIN
Journal: Annals of Internal Medicine (1983)

Letters and Corrections1 August 1983Captopril and EnalaprilJONATHAN K. WILKIN, M.D.JONATHAN K. WILKIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-99-2-281_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The observation by Gavras and Gavras (1) that four patients with adverse reactions while on Captopril subsequently had no reactions when enalapril was substituted is interesting. Also, the conclusion that angiotensin-converting enzyme inhibition is a safe treatment for hypertension, even for patients with previously documented reactions to Captopril, seems reasonable.Several issues are obscured in their letter, however. First, there has been a downward evolution of the dosage of Captopril used in the treatment of hypertension. At least some of the adverse effects are dose related: The average daily dosage of Captopril at the onset of the...References1. GAVRASGAVRAS IH. Captopril and enalapril [Letter]. Ann Intern Med. 1983;98:556-7. LinkGoogle Scholar2. WILKINHAMMONDKIRKENDALL JJW. The captopril-induced eruption. Arch Dermatol. 1980;116:902-5. CrossrefMedlineGoogle Scholar1. GAVRASGAVRAS IH. Captopril and enalapril [Letter]. Ann Intern Med. 1983;98:556-7. LinkGoogle Scholar2. PANAYIWOOLEYBATCHELOR GPJ. Genetic basis of rheumatoid disease: HLA antigens, disease manifestations and toxic reactions to drugs. Br Med J. 1978;2:1326-8. CrossrefMedlineGoogle Scholar3. ROTMENSHVLASSESFERGUSON HPR. Resolution of captoprilinduced rash after substitution of enalapril. Pharmacotherapy. 1983;3:131-3. CrossrefMedlineGoogle Scholar4. IGICGAFFORDERDÖS RJE. Effect of Captopril on proteins and peptide hormones. Biochem Pharmacol. 1981;30:683-5. CrossrefMedlineGoogle Scholar5. Veterans Administration cooperative study group on antihypertensive agents. Captopril: evaluation of low doses, twice daily doses and the addition of diuretic for the treatment of mild to moderate hypertension. Clin Sci. 1982;63:443-5. CrossrefGoogle Scholar6. JOHNSENAURELL SM. Immunosuppressive action of Captopril blocked by prostaglandin synthetase inhibitor. Lancet. 1981;1:1005. CrossrefMedlineGoogle Scholar7. STUDERVETTER AW. Reversible leucopenia associated with angiotensin-converting enzyme inhibitor MK-421. Lancet. 1982; 1:458. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: McGuire Veterans Administration Medical Center Richmond, VA 23249 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByHigh-risk patients treated with enalapril maleate: safety considerationsAcute hemodynamic and hormonal effects of lisinopril (MK-521) in congestive heart failureEnalapril: A New Angiotensin Converting Enzyme InhibitorEnalapril, A Rash, and CaptoprilSPENCER H. KUBO, M.D., ROBERT J. CODY, M.D. 1 August 1983Volume 99, Issue 2Page: 281-281KeywordsAdverse reactionsAngiotensin converting enzymeHypertension Issue Published: 1 August 1983 PDF DownloadLoading ...