tbuckley/cabot-search huggingface dataset:
Matrix Metalloproteinase Inhibition Attenuates Early Left Ventricular Enlargement After Experimental Myocardial Infarction in Mice
Authors: Luis E. Rohde, Anique Ducharme, Luis H. Arroyo, Masanori Aikawa, Galina H. Sukhova, Arturo Lopez-Anaya, Kim F. McClure, Peter G. Mitchell, Peter Libby, Richard T. Lee
Journal: Circulation (1999)

Background —Extracellular matrix synthesis and degradation contribute to the morphological changes that occur after myocardial infarction (MI). Methods and Results —We tested the hypothesis that inhibition of matrix metalloproteinases (MMPs) attenuates left ventricular remodeling in experimental MI. Seventy-one male FVB mice that survived ligation of the left anterior coronary artery were randomized to a broad-spectrum MMP inhibitor (CP-471,474) or placebo by gavage. Echocardiographic studies were performed before randomization (within 24 hours of surgery) and 4 days later and included short-axis imaging at the midpapillary and apical levels. Infarction as defined by wall motion abnormality was achieved in 79% of the procedures (n=56), and mortality rate during the 4-day protocol was 23% (9 of 36 on treatment vs 7 of 35 on placebo; P =NS). Baseline end-diastolic and end-systolic dimensions and areas were similar ( P =NS) between treated and placebo groups. At follow-up, infarcted mice allocated to MMP inhibitor had significantly smaller increases in end-systolic and end-diastolic dimensions and areas at both midpapillary and apical levels compared with infarcted mice allocated to placebo (all P &lt;0.05). In addition, infarcted animals that received MMP inhibitor had no change in fractional shortening (−3±13%), whereas animals that received placebo had a decrease in fractional shortening (−12±12%) ( P &lt;0.05). In an analysis stratified by baseline end-diastolic area, the effects of MMP inhibition on the changes in end-systolic area and end-diastolic area were most prominent in animals that had more initial left ventricular dilatation (both P &lt;0.05). Conclusions —–Administration of an MMP inhibitor attenuates early left ventricular dilation after experimental MI in mice. Further studies in genetically altered mice and other models will improve understanding of the role of MMPs in left ventricular remodeling.
Is Subspecialty Training Financially Worthwhile?
Authors: Alexander B. White
Journal: Annals of Internal Medicine (1992)

Letters15 February 1992Is Subspecialty Training Financially Worthwhile?Alexander B. White, MDAlexander B. White, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-116-4-349 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors:I would like to comment on the article on subspecialty training (1). As a practicing internist for approximately 35 years with a multisubspecialty group, I can testify that your estimates are quite correct. Invasive cardiologists, followed by hematologist-oncologists, gastroenterologists, pulmonologists, and nephrologists, are the largest beneficiaries of the additional 2 years of training. General internists, followed by rheumatologists, infectious disease specialists, and endocrinologists, benefit least. Training general internists at least in such procedures as colonoscopy would not only help financially but also would aid in routine screening for colonic polyps....Reference1. Prashker M and Meenan R. Subspecialty training: is it financially worthwhile? Ann Intern Med. 1991;115:715-9. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Alexander B. White, MDAffiliations: Olympia Fields Internal Medicine Associates, S.C. Olympia Fields, IL 60461 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 February 1992Volume 116, Issue 4 Page: 349-349 Keywords Colonoscopy Gastroenterology and hepatology Hematology and oncology Infectious diseases ePublished: 1 December 2008 Issue Published: 15 February 1992 PDF downloadLoading ...
Public attitudes towards kidney transplantation.
Authors: B Moores, G Clarke, B R Lewis, N P Mallick
Journal: BMJ (1976)

A representative sample of 500 members of the public was interviewed about kidney transplantation. The survey showed that despite widespread awareness of the need for kidney donors only 4.4% of the respondents had completed a donor card. The small percentage holding kidney donor cards appears to reflect a failure to inform and motivate the general public. There was no evidence of any widespread objection to the procedures involved in obtaining cadaver kidneys, but there was strong objection to the introduction by law of an "opting out" system. The findings suggest how the numbers of potential donors could be increased without changing the law as regards consent to donation.
Use your head and put a hat on it
Authors: M. D Moncrieff, J. Garioch
Journal: BMJ (2008)

Soluble tumor antigen was prepared from two transplanted sarcomas of strain 13 guinea pigs, induced with 3-methylcholanthrene or 9,10-dimethyl-1,2-benzanthracene, by extraction with isotonic saline followed by ultracentrifugation. Further fractionation by ammonium sulfate precipitation, gel filtration on Sephadex G-150 or Biogel A-5m, and DEAE Sephadex chromatography was performed. Antigenic activity was assayed in vivo by skin tests and in vitro by the macrophage migration inhibition method. Antigenic activity was not restricted to a single species of molecules as defined by size or charge. The major part of the activity was associated with two fractions, one excluded by Sephadex G-150, and the other included in Sephadex G-150. The behavior of the antigen preparations in isopycnic sucrose gradient centrifugation indicated that they were truly soluble and not membrane associated. The active fractions were nontoxic for the skin and for peritoneal cells and stable under the conditions of the macrophage migration test. Their antigenic activity was specific for each of the two tumors. In terms of the amount of antigen required to give a positive reaction, the migration inhibition assay was more sensitive than the skin tests.
Further steps toward a second-person neuroscience
Authors: Nehdia Sameen, Joseph Thompson, Jeremy I. M. Carpendale
Journal: Behavioral and Brain Sciences (2013)

Schilbach et al. contribute to neuroscience methodology through drawing on insights from the second-person approach. We suggest that they could further contribute to social neuroscience by more fully spelling out the ways in which a second-person approach to the nature and origin of thinking could transform neuroscience.
Modulation of erythrocyte membrane mechanical stability by 2,3-diphosphoglycerate in the neonatal poikilocytosis/elliptocytosis syndrome.
Authors: W C Mentzer, T A Iarocci, N Mohandas, P A Lane, B Smith, J Lazerson, T Hays
Journal: Journal of Clinical Investigation (1987)

To explain the transient anemia and poikilocytosis seen during infancy in hereditary elliptocytosis (HE), we resealed erythrocyte (RBC) ghosts from affected children or their elliptocytic parents with 2,3-diphosphoglycerate (DPG) (0-8 mM), a compound that dissociates membrane skeletons, then measured ghost mechanical stability in the ektacytometer. Without added 2,3-DPG, ghost mechanical stability was subnormal in infantile poikilocytosis (IP) and HE but was even more abnormal in hereditary pyropoikilocytosis (HPP). Addition of 2,3-DPG (2.55 mM) to IP or HE ghosts, decreased their stability to that of HPP ghosts (without 2,3-DPG). Nonphysiological 2,3-DPG levels (6-8 mM) were required to elicit a similar effect in normal ghosts. The data suggest that free 2,3-DPG, present in neonatal RBC as a consequence of diminished binding to HbF, may render HE susceptible to in vivo fragmentation. The developmental switch from fetal to adult hemoglobin, by diminishing available free 2,3-DPG, may explain the abatement of poikilocytosis and hemolytic anemia that accompanies maturation.
A possible role for antibodies to tumour necrosis factor alpha and to endotoxin in the treatment of Reye's syndrome.
Authors: M Odeh
Journal: Gut (1995)

HypothesisA possible role for antibodies to tumour necrosis factor ox and to endotoxin in the treatment of Reye's syndrome M OdehReye's syndrome is a severe and often fatal disease of unknown aetiology and pathogenesis that affects children after viral illness.l1AIt is characterised by encephalopathy and acute fatty degeneration of the liver.1-4Epidemio- logical studies have suggested a close associa- tion with the development of Reye's syndrome and administration of aspirin to children infected with different types of viruses, where over 95% of children with the full blown syndrome have a history of aspirin ingestion.5 6A role for endotoxin in the development of Reye's syndrome was suggested by Cooperstock et al,7 who found increased con- centrations of endotoxin in plasma from patients with Reye's syndrome.Furthermore, several investigators have shown that adminis- tration of a sublethal dose of endotoxin to fasted Sprague-Dawley rats produces meta- bolic changes and histological changes similar to those reported in Reye's syndrome.89As endotoxin may cause most of its biological effects by the release of tumour necrosis factor ot (TNF),10-14 and as many of the metabolic effects associated with Reye's syndrome may be mediated by TNF,15 it is reasonable to assume an important role for TNF in the pathogenesis of Reye's syndrome.
Morphometric study of the small intestinal mucosa in young, adult, and old rats submitted to protein deficiency and rehabilitation.
Authors: M A Rodrigues, J L de Camargo, K I Coelho, M R Montenegro, A Y Angeleli, R C Burini
Journal: Gut (1985)

Linear and stereological morphometric methods were applied to the jejunal and ileal mucosa of young, adult, and old male Wistar rats submitted to protein deficiency and rehabilitation. The animals were fed ad libitum a 2% casein diet during 42 days and then received a 20% casein diet for 30 days. Food intake, body weights, and plasma protein concentrations were recorded. In the young protein deficient rats values of mucosal height, surface area, and volume of the lamina propria were significantly lower than those of their age controls in both jejunum and ileum. In adults the differences were less marked and in the old rats all parameters were found to be unaltered by the protein deficient diet. The surface-to-volume ratio showed no significant differences between control and protein deficient in all three age groups, meaning that villus pattern did not change with protein deficiency. On rehabilitation, a striking difference between jejunum and ileum was observed in the young rats; all parameters returned to control levels in the jejunum, while they remained lower than those of their controls in the ileum.
Apixaban was noninferior to enoxaparin plus warfarin in patients with acute venous thromboembolism
Authors: Thomas DeLoughery
Journal: Annals of Internal Medicine (2013)

ACP Journal ClubOctober 15, 2013Apixaban was noninferior to enoxaparin plus warfarin in patients with acute venous thromboembolismThomas DeLoughery, MD, FACP, FAWMThomas DeLoughery, MD, FACP, FAWMOregon Health & Science University, Portland, Oregon, USA (T.D.)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-159-8-201310150-02002 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationAgnelli G, Buller HR, Cohen A, et al; Amplify Investigators. Oral apixaban for the treatment of acute venous thromboembolism. N Engl J Med. 2013;369:799-808. https://pubmed.ncbi.nlm.nih.gov/23808982Clinical Impact RatingsEmergency Med: Hematology: References1 Schulman S, Kearon C, Kakkar AK, et al; RE-COVER Study Group. Dabigatran versus warfarin in the treatment of acute venous thromboembolism. N Engl J Med. 2009;361:2342-52. [PMID: 19966341] Google Scholar2 EINSTEIN Investigators, Bauersachs R, Berkowitz SD, et al. Oral rivaroxaban for symptomatic venous thromboembolism. N Engl J Med. 2010;363:2499-510. [PMID: 21128814] Google Scholar3 EINSTEIN–PE Investigators, Büller HR, Prins MH, et al. Oral rivaroxaban for the treatment of symptomatic pulmonary embolism. N Engl J Med. 2012;366:1287-97. [PMID: 22449293] Google Scholar4 Lu G, DeGuzman FR, Hollenbach SJ, et al. A specific antidote for reversal of anticoagulation by direct and indirect inhibitors of coagulation factor Xa. Nat Med. 2013;19:446-51. [PMID: 23455714] Google Scholar Author, Article, and Disclosure InformationAffiliations: Oregon Health & Science University, Portland, Oregon, USA (T.D.) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics October 15, 2013Volume 159, Issue 8Page: JC2 Issue Published: October 15, 2013 Copyright & PermissionsCopyright © 2013 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
First case of stenting of a vulnerable plaque in the SECRITT I trial—the dawn of a new era?
Authors: Steve Ramcharitar, Nieves Gonzalo, Robert Jan van Geuns, Hector M. Garcia-Garcia, Joanna J. Wykrzykowska, Jurgen M. R. Ligthart, Evelyn Regar, Patrick W. Serruys
Journal: Nature Reviews Cardiology (2009)
Abstract 3957: Cardiac metastasis in mice with primary breast carcinoma.
Authors: Yong Zhang, Nan Zhang, Robert M. Hoffman, Ming Zhao
Journal: Cancer Research (2013)

Abstract The incidence of cardiac metastases reported in the literature ranges from 2.3% to 18.3%. Cancer cells invade the heart either directly or through the blood stream or lymphatics. This report describes cardiac metastasis from primary breast carcinoma in an orthotopic nude mouse model. 4T1 mammary carcinoma cells expressing FP were orthotopically implanted into the right second mammary fat pad of BALB/c mice. When the average tumor volume reached approximate 500-600 mm3, the 4T1 primary tumors were removed at approximately day-18 after tumor implantation. At autopsy, 2 of 12 mice were found to have metastasized to the heart, as brightly visualized by RFP fluorescence, when the mice were sacrificed 6-8 weeks after cell implantation. Post-mortem histological and frozen sample sections showed extensive tumor infiltration into the pericardium, epicardium, and myocardium. The novel mouse model of cardiac metastasis can be used to screen for effective agents. Citation Format: Yong Zhang, Nan Zhang, Robert M. Hoffman, Ming Zhao. Cardiac metastasis in mice with primary breast carcinoma. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3957. doi:10.1158/1538-7445.AM2013-3957
445 The pharmacokinetics (PK) and safety of a single dose of adefovir dipivoxil (ADV) in children and adolescents (aged 2–17) with chronic hepatitis B
Authors: E. Sokal, D. Kelly, S. Wirth, J. Mizerski, B. Lu, K. Kleber, J. Shah, G. Currie, C.L. Brosgart
Journal: Journal of Hepatology (2004)
Accumulation of adoptively transferred adherent, lymphokine-activated killer cells in murine metastases.
Authors: P Basse, R B Herberman, U Nannmark, B R Johansson, M Hokland, K Wasserman, R H Goldfarb
Journal: The Journal of Experimental Medicine (1991)

While close contact between lymphokine-activated killer (LAK)/adherent, lymphokine-activated killer (A-LAK) cells and tumor cells is believed to be a prerequisite for initiating the events leading to tumor cell lysis, clear evidence for the ability of these effector cells to infiltrate tumors or tumor metastases in vivo still has to be obtained. In the present study, we report that a significant fraction of adoptively transferred A-LAK cells, labeled with fluorochromes for identification, accumulates in lung and liver metastases of the B16 melanoma, the MCA 102 sarcoma and the Lewis lung carcinoma lines. Thus, 5- to 10-fold higher numbers of A-LAK cells were found in the malignant lesions compared to the surrounding normal tissue. The infiltration seemed very heterogeneous after intravenous injection of moderate numbers of A-LAK cells (15 x 10(6)). However, after adoptive transfer of 45 million A-LAK cells, an A-LAK cell/tumor cell ratio higher than 1:1 in most metastases was observed. Surprisingly, approximately 5% of the lung metastases seemed totally resistant to infiltration even though neighboring metastases were highly infiltrated. While substantial infiltration of lung metastases was seen after i.v. injection, significant infiltration of liver metastases was seen only after intraportal injection of the A-LAK cells indicating impaired traffic of intravenous injected A-LAK cells through the lung capillaries. These results present direct evidence that A-LAK cells, upon a proper route of administration, have the potential to migrate to and heavily infiltrate metastases from murine tumors of different origin.
Insulin resistance in offspring of hypertensive parents.
Authors: O L Beatty, R Harper, B Sheridan, A B Atkinson, P M Bell
Journal: BMJ (1993)

OBJECTIVE--To determine if insulin resistance is present in normotensive adults at increased risk of developing hypertension. DESIGN--Normotensive subjects with at least one hypertensive parent were paired with offspring of normotensive parents (controls), being matched for age, sex, social class, and physical activity. SETTING--Outpatient clinic. SUBJECTS--30 paired subjects (16 men and 14 women) with and without a family history of hypertension, aged 18-32, with a body mass index &lt; 25 kg/m2, with blood pressure &lt; 130/85 mm Hg, and not taking drugs. INTERVENTIONS--Euglycaemic glucose clamp (two hour infusion of insulin 1 mU/kg/min) and intravenous glucose tolerance test (injection of 100 ml 20% glucose). MAIN OUTCOME MEASURES--Insulin mediated glucose disposal and insulin secretion. RESULTS--The offspring of hypertensive parents had slightly higher blood pressure than did the controls (mean 117 (SD 6) v 108 (5) mm Hg systolic, p = 0.013; 76 (7) v 67 (6) mm Hg diastolic, p = 0.017). Their insulin mediated glucose disposal was lower than that of controls (29.5 (6.5) v 40.1 (8.6) mumol/kg/min, p = 0.002), but, after adjustment for blood pressure, the difference was not significant (difference 6.9 (95% confidence interval -1.5 to 15.3), p = 0.10). Insulin secretion in the first hour after injection of glucose was slightly but not significantly higher in the offspring of hypertensive patients (9320 (5484) v 6723 (3751) pmol.min/l). The two groups had similar concentrations of plasma glucose (5.2 (0.3) v 5.1 (0.4) mmol/l), serum cholesterol (4.4 (0.8) v 4.6 (0.8) mmol/l), serum triglyceride (0.89 (0.52) v 0.68 (0.27) mmol/l), and serum low density lipoprotein cholesterol (2.81 (0.65) v 2.79 (0.61) mmol/l). The offspring of hypertensive parents, however, had lower serum concentrations of high density lipoprotein cholesterol (1.24 (0.31) v 1.56 (0.35) mmol/l, p = 0.002) and higher serum concentrations of non-esterified fatty acids (0.7 (0.4) v 0.4 (0.4) mmol/l, p = 0.039). CONCLUSIONS--Young normotensive subjects who are at increased risk of developing hypertension are insulin resistant.
Contact dermatitis and gastrointestinal symptoms from hydroxyethylmethacrylate
Authors: C.G.TOBY MATHIAS, TURNER M. CALDWELL, HOWARD I. MAIBACH
Journal: British Journal of Dermatology (1979)

A laboratory technician developed allergic contact dermatitis to hydroxyethylmethacrylate associated with nausea, diarrhoea and persistent paresthesiae of the fingertips. The gastrointestinal symptoms were reproduced by patch testing. Hydroxyethylmethacrylate was demonstrated to pass through vinyl gloves. Cross reactions occurred to methyl-, ethyl-, propyl- and isopropylmethacrylate but not to butyl- or isobutylmethacrylate.
Mistaken Drug Identity Mimicking Cerebral Vascular Insufficiency
Authors: Albert J. Finestone
Journal: JAMA (1970)

<h3>To the Editor.—</h3> Cerebral vascular insufficiency is not uncommon in the elderly, particularly those with diabetes. We have recently encountered a patient with symptoms suggestive of cerebral vascular insufficiency, but on closer scrutiny, she had symptoms produced by improper dosage of drugs which closely resembled one another in physical appearance ( Figure). <h3>Report of a Case.—</h3> A 78-year-old woman and known diabetic since 1968, currently under treatment with tolbutamide, 500 mg twice a day, was in her usual health until two weeks prior to admission because of the abrupt onset of lower extremity weakness associated with lightheadedness. On one occasion the patient fell and struck her head. In the emergency department on two different occasions, it was thought that the patient had cerebral vascular insufficiency as a cause of her symptoms. Physical examination including neurologic examination revealed no localizing abnormalities. Laboratory examinations showed a fasting blood glucose level of 205 mg/100
Distribution and Activity of Antineoplastic Drugs in a Tumor Model
Authors: R. E Durand
Journal: JNCI Journal of the National Cancer Institute (1989)

Journal Article Distribution and Activity of Antineoplastic Drugs in a Tumor Model Get access Ralph E Durand Ralph E Durand Medical Biophysics Unit, BC. Cancer Research Centre601 West 10th Ave., Vancouver, BC, Canada V5Z 1L3 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 81, Issue 2, 18 January 1989, Pages 146–152, https://doi.org/10.1093/jnci/81.2.146 Published: 18 January 1989 Article history Received: 20 June 1988 Revision received: 29 September 1988 Accepted: 04 October 1988 Published: 18 January 1989
The Michigan Practice of Medicine Act.
Authors: G. B. Allen
Journal: JAMA (1895)

Charlotte, Mich., July 1, 1895. <h3>To the Editor:</h3> —In theJournalof June 15, in the editorial columns, I notice the report of the Michigan Medical Society for its recent meeting. I wish to call your attention to this paragraph which I herewith quote: "Michigan, still, by deliberate act of its Legislature, remains the dumping ground for the world's incompetent and dishonest doctors." The Legislature of Michigan in its last session passed the bill to regulate the practice of medicine and to prevent that which you deplore, as well as all honest and intelligent people. It would have become a law,<i>but for the veto of the Governor</i>, who only exercised that prerogative after the Legislature had adjourned, and could not pass it over the veto for that reason. Hoping you will correct the misstatement, and do justice to at least a portion of Michigan's unfortunates, I remain yours, Member