Interferon in Malaria
Authors: MICHAEL WEINTRAUB
Journal: Annals of Internal Medicine (1970)

Letters and Comments1 December 1970Interferon in MalariaMICHAEL WEINTRAUB, M.D.MICHAEL WEINTRAUB, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-73-6-1045 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In the recent NIH Conference report, Malaria: Host-Defense Mechanisms and Complications, presented in the August 1970 ANNALS, Dr. John N. Sheagren discussed several types of defense mechanisms, such as antibodies, immunoglobulins, complement, cellular immune factors, and phagocytosis.There is some early experimental evidence in animals that another aspect of host response, interferon, may play a role in malarial infections.Jahiel and his co-workers (1, 2) and Huang and his associates (3, 4) have worked on simultaneous arbovirus and plasmodia infections. Various interferon inducers (Newcastle disease virus, Statolan, and polyriboninosinic acid) were shown by Jahiel and colleagues (1)...References1. JAHIELVILCEKNUSSENZWEIG RJR: Interferon inducers protect mice against P. berghei malaria. Science 161: 802-804, 1968 CrossrefMedlineGoogle Scholar2. JAHIELNUSSENZWEIGVANDERBERT RRJ: Antimalarial effect of interferon inducers at different stages of development of P. berghei in the mouse. Nature (London) 220:710-711, 1968 CrossrefMedlineGoogle Scholar3. SCHULTZHUANGGORDON WKF: Role of interferon in experimental mouse malaria. Nature (London) 220:709-710, 1968 CrossrefMedlineGoogle Scholar4. HUANGSCHULTZGORDON KWF: Interferon induced by P. berghei Science 162-123-124, 1968 CrossrefMedlineGoogle Scholar5. JAHIELNUSSENZWEIGVILCEK RRJ: Protective effects of interferon on Plasmodium berghei. Amer J Trop Med 18:823-835, 1969 CrossrefMedlineGoogle Scholar1. MACGREGORSHEAGRENWOLFF RJS: Endotoxin-induced modification of Plasmodium Berghei infection in mice. J Immunol 102:131-139, 1969 MedlineGoogle Scholar2. HO M: Interferon-like viral inhibitor in rabbits after intravenous administration of endotoxin. Science 146:1472-1473, 1964 CrossrefMedlineGoogle Scholar3. STINEBRINGYOUNGER WJ: Patterns of interferon appearance in mice injected with bacteria or bacterial endotoxin. Nature (London) 204:712, 1964 CrossrefMedlineGoogle Scholar4. BARONLEVY SH: Interferon. Ann Rev Microbiol 20:291-318, 1966 CrossrefMedlineGoogle Scholar5. WEINSTEINWAITZCARNE MJP: Induction of resistance to bacterial infection of mice with poly I: poly C. Nature (London) 226:170, 1970 CrossrefMedlineGoogle Scholar6. REMINGTONMERIGAN JT: Interferon protection of cells infected with an intracellular protozoan (Toxoplasma gondii). Science 161:804-806, 1968 CrossrefMedlineGoogle Scholar7. MACKANESSBLANDEN GR: Cellular immunity, in Progress in Allergy, vol. 11. New York, S. Karger, 1967, pp. 89-140 CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: U.C.L.A. Center for the Health Sciences Los Angeles, Calif. 90024 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByProtection of athymic (Nu/Nu) BALB/c mice against Plasmodium berghei by splenocytes from normal (Nu/ +) BALB/c mice 1 December 1970Volume 73, Issue 6Page: 1045-1046KeywordsAntibodiesInterferonsMalariaPhagocytosis Issue Published: 1 December 1970 PDF DownloadLoading ...