tbuckley/cabot-search huggingface dataset:
Thrombolysis in unstable angina. Randomized double-blind trial of t-PA and placebo.
Authors: M R Freeman, A Langer, R F Wilson, C D Morgan, P W Armstrong
Journal: Circulation (1992)

BACKGROUND Because coronary thrombosis is important in the pathogenesis of unstable angina and correlates with in-hospital cardiac events, we hypothesized that thrombolytic therapy would decrease cardiac events. METHODS AND RESULTS We randomized 70 patients with unstable angina to tissue-type plasminogen activator (t-PA) (0.49 MU/kg for 1 hour followed by 0.07 MU/kg per hour for 9 hours) or placebo. All patients received full doses of intravenous heparin for 96 hours and aspirin (325 mg beginning at 72 hours). The primary end points of the study were in-hospital death, myocardial infarction, and urgent revascularization. Three secondary end points were also evaluated. Myocardial perfusion was assessed with resting planar thallium scintigraphy 90 minutes after initiation of therapy. Silent ischemia was assessed with 48-hour Holter monitoring for ST shift beginning at time of initiation of drug therapy. Coronary angiography was performed at 18 +/- 6 hours and analyzed quantitatively to assess the stenosis responsible for unstable angina, the presence of intraluminal filling defects consistent with intracoronary thrombus, and stenosis morphology and severity. There was no difference in total in-hospital cardiac events between patients receiving t-PA (5% or 14%) and those receiving placebo (7% or 20%) (p = 0.83). Resting thallium defects were larger in the patients receiving t-PA than in those receiving placebo (130 +/- 118 versus 76 +/- 84 degrees, p less than 0.04), and this difference persisted when corrected for previous infarction. Although the numbers of patients with ST shift were similar, the duration of ST shift was significantly longer in the patients receiving t-PA than with placebo (20 +/- 46 versus 3 +/- 10 minutes, p less than 0.045). The frequency of intracoronary thrombi in patients with stenoses greater than 50% was significantly less in patients treated with t-PA (11 of 22, 52%) as compared with placebo (23 of 25, 92%) (p = 0.002), but there was no significant difference in minimal lesion cross-sectional area (0.49 +/- 0.42 versus 0.57 +/- 1.08 cm2, p = 0.75) or ulceration index (0.79 +/- 0.16 versus 0.77 +/- 0.15, p = 0.71) of the culprit artery. CONCLUSIONS We conclude that a prolonged infusion of t-PA in unstable angina reduces intracoronary thrombi but does not significantly decrease in-hospital cardiac events. The sample size, however, does not provide sufficient power to rule out a treatment effect. Paradoxically, there appears to be an increase in ST shift and worsening of myocardial perfusion with t-PA compared with therapy with heparin alone.
High consumption of red meat and processed meat was associated with increased risk for mortality
Authors: Joel Schectman
Journal: Annals of Internal Medicine (2009)

ACP Journal Club21 July 2009High consumption of red meat and processed meat was associated with increased risk for mortalityJoel Schectman, MDJoel Schectman, MDUniversity of Virginia Health System, Charlottesville, Virginia, USA (J.S.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-151-2-200907210-02015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationSinha R, Cross AJ, Graubard BI, Leitzmann MF, Schatzkin A. Meat intake and mortality: a prospective study of over half a million people. Arch Intern Med. 2009;169:562-71. https://pubmed.ncbi.nlm.nih.gov/19307518Clinical Impact RatingsGIM/FP/GP: Cardiology: Oncology: Reference1 American College of Physicians. Guidelines for counseling postmenopausal women about preventive hormone therapy. Ann Intern Med. 1992;117:1038-41. [PMID: 1443972] Google Scholar Author, Article, and Disclosure InformationAuthors: Joel Schectman, MDAffiliations: University of Virginia Health System, Charlottesville, Virginia, USA (J.S.)This article was published at Annals.org on 7 July 2009. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBioactive Peptides from Meat Proteins as Functional Food Components 21 July 2009Volume 151, Issue 2 Page: JC1-15 Keywords Cancer epidemiology Cohort studies Congenital heart disease Estrogens Exercise Health statistics Hormonal therapy Hormones Meat Mortality ePublished: 21 July 2009 Issue Published: 21 July 2009 Copyright & PermissionsCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Letter: CCNU in teatment of recurrent medulloblastoma.
Authors: H W Ward
Journal: BMJ (1974)

bilirubinemia in the newborn, as has been suggested.5Finally, practically nothing is known.about the influence of diazepam upon the developing fetal brain or the developing neurological functions of the newborn.Thus we do not reconmnend the subchronic use of diazepam in any stage of pregnancy or in doses higher than 10-20 mg to the mother during labour.-Weare, etc.,
Uniform brain tumor distribution and tumor associated macrophage targeting of systemically administered dendrimers
Authors: Fan Zhang, Panagiotis Mastorakos, Manoj K. Mishra, Antonella Mangraviti, Lee Hwang, Jinyuan Zhou, Justin Hanes, Henry Brem, Alessandro Olivi, Betty Tyler, Rangaramanujam M. Kannan
Journal: Biomaterials (2015)
Animals in Research
Authors: John T. Harrington
Journal: JAMA (1988)

To the Editor.—  As a practicing nephrologist and a recipient of a bovine pericardial aortic valve, I am vitally aware of the importance of animal research to biomedical investigation and medical progress. Without the 40 to 50 years of animal research that made open heart surgery possible, I would be dead. The recent commentary by Drs Smith and Hendee1is a timely one, given the number of attacks made recently on even the responsible use of animals in medical research. It would be irresponsible of me to remain quiet during this debate. I believe that physicians have a responsibility to speak out clearly for the continued use of animals in fundamental biomedical research. Society at large must be better informed so that it can make the proper decisions, whether through the voting booth or through direct communication to its elected representatives. We need to share our knowledge of animal
Predictors of adverse clinical outcome in the randomized evaluation of covered stent in saphenous vein graft (RECOVERS) trial
Authors: Goran Stankovic, Antonio Colombo, Fabio Sgura, Flavio Airoldi, Carlo Briguori, Nicholaous Reifart, Patrizia Presbitero, Luigi Inglese, G. Heyndrickx, Carlo Di Mario
Journal: Journal of the American College of Cardiology (2003)
Cholesterol and Cancer-Reply
Authors: Richard J. Jones
Journal: JAMA (1982)

In Reply.—  The initial observation that Dr Heyden makes was also made by the authors of the Los Angeles VA study, which was mentioned largely for historical interest and by way of introducing the subject of the editorial. The same authors concluded that this observation reduces the possibility that the feeding of polyunsaturated oils was responsible for the excess carcinoma mortality. Most statisticians would not accept Dr Heyden's subdivision of groups carefully established before the experiment, but if we pursue it a little further and simply examine those who adhered to either diet assignment more than 50% of the time, there were carcinomas found in only 5% of the control group as compared with 8% of the experimental group. While these numbers now lose statistical significance, they are not as reassuring to me as they may be to Dr Heyden. It should also be observed that there is no assurance,
Improvement of glucose tolerance and lowering of glycohemoglobin and serum lipid concentrations after discontinuation of antihypertensive drug therapy.
Authors: R P Ames, P Hill
Journal: Circulation (1982)

Diuretic-based antihypertensive drug therapy causes a disturbance in glucose tolerance and in serum lipid and lipoprotein concentrations. To determine the reversibility of the glucose intolerance and to identify mechanisms of the metabolic alterations, we examined a short glucose tolerance test and insulin, glycohemoglobin and lipid concentrations during the supervised withdrawal of long-term drug therapy in 35 patients with primary hypertension. An average of 7 weeks after stopping drugs, glucose tolerance and glycohemoglobin improved, total cholesterol decreased 18 mg/dl, triglyceride decreased 27 mg/dl, and the ratio of total to high-density lipoprotein cholesterol decreased (p less than 0.01 for all variables vs treatment values). The changes in lipid concentrations from the treated to untreated state correlated with the changes in glycohemoglobin and indexes of glucose metabolism. The findings suggest that insulin resistance develops during drug therapy and disturbs both glucose and lipid metabolism. Attention to these alterations may provide directions for further control of atherosclerotic complications during the treatment of hypertension.
Hypokalaemia in influenza.
Authors: G S Crockett
Journal: BMJ (1970)

endocrine hypothesis.For example, there must be in the population many men who have regularly donated blood every six months for many years.Obviously this is not equivalent to a monthly menstrual bleed.Nevertheless it would be interesting to see whether these men are in any way protected against coronary thrombosis as compared with a group of non-donors.(2) If true the concept would mean that protection against coronary thrombosis could be provided at very low cost.There would be no need for life-long drug taking or dietary changes.
Molecular Diagnosis and Ocular Imaging of West Nile Virus Retinitis and Neuroretinitis
Authors: Rathinam R. Sivakumar, Lalitha Prajna, Lalan Kumar Arya, Praveen Muraly, Jyoti Shukla, Divyasha Saxena, Manmohan Parida
Journal: Ophthalmology (2013)
Public's satisfaction with NHS fell by 12% in 2011
Authors: I. Torjesen
Journal: BMJ (2012)

A passing score on the American Society for Clinical Pathology (ASCP) Board of Certification (BOC) exam is a metric of a students’ academic success in most Clinical Laboratory Science/Medical Laboratory Science (CLS/MLS) programs. It would be ideal if CLS/MLS programs are able to predict a student’s success when an individual applies for admission to a CLS/MLS program. This study aimed to demonstrate that there is a positive correlation between admissions scores at the Texas Tech University Health Science Center (TTUHSC) School of Health Professions (SHP) and students’ performance on the BOC exam. Using simple linear regression analysis with Pearson correlation, specific criteria that are part of the application and admissions scoring process were used to determine the relationship. The results of the study showed moderate positive correlation with BOC exam performance, and although the admissions criteria at TTUHSC only moderately predict student success, they provide enough information to make an admissions decision on students who would have the best chance of success in the TTUHSC CLS program and the profession.
447 Reinfection with the hepatitis C virus: Kinetics of viral clearance and multi-parameter analysis of CD4+ T-cell response
Authors: L. Weseslindtner, J.H. Aberle, C. Gurguta, P. Steindl-Munda, T. Popow-Kraupp, P. Ferenci, H. Holzmann
Journal: Journal of Hepatology (2006)
Nanoparticle-mediated drug delivery to tumor neovasculature to combat P-gp expressing multidrug resistant cancer
Authors: Fan Bai, Chao Wang, Qin Lu, Mei Zhao, Fu-Qiang Ban, De-Hong Yu, Ying-Yun Guan, Xin Luan, Ya-Rong Liu, Hong-Zhuan Chen, Chao Fang
Journal: Biomaterials (2013)
Lumbar Puncture in the Presence of Raised Intracranial Pressure
Authors: G. P. Duffy
Journal: BMJ (1969)

Study of 30 patients with raised intracranial pressure whose condition worsened after lumbar puncture emphasizes the danger of carrying this out in the presence of raised intracranial pressure. In half the cases deterioration was immediate and dramatic, and in the other half it occurred within 12 hours. Probably a tentorial or cerebellar pressure cone, or both, had formed before lumbar puncture, and the procedure made this worse and caused the clinical deterioration. A history of progressive headache associated with mental changes, and the development and progression of localizing neurological signs were the two features suggestive of varied intracranial pressure found most constantly in this series. A good quality plain <i>x</i>-ray film is important in the diagnosis of this condition.
Successful treatment of psoriasis with topical application of active vitamin D3 analogue, 1α, 24-dihydroxycholecalciferol
Authors: T. KATO, M. ROKUGO, T. TERUI, H. TAGAMI
Journal: British Journal of Dermatology (1986)

We treated 11 psoriatic patients with topical 1 alpha,24-dihydroxycholecalciferol, a new synthetic analogue of active vitamin D3. In 10 of 15 tests the lesions cleared completely within 1-4 weeks, although some relapses occurred shortly after cessation of treatment. There were no side-effects. We suggest that 1 alpha, 24(OH)2D3 merits further investigation as a potentially useful topical therapy for psoriasis.
Hepatitis B: risk to expatriates in South East Asia.
Authors: D G Dawson, G H Spivey, J J Korelitz, R T Schmidt
Journal: BMJ (1987)

Comment-The normal secretion ofgrowth hormone is inhibited by somatostatin and stimulated by growth hormone releasing factor.The same effects are also evident in most patients with acromegaly.Release of somatostatin may be stimulated and release of growth hormone releasing factor inhibited by reduced hypothalamic dopamine content, which in turn may be caused by chronic hyperprolactinaemia.5The hyperprolactinaemia in our patient may thus have led to increased release of somatostatin and decreased release of growth hormone releasing factor, reflected by the "low" growth hormone concentrations despite this patient's longlasting, clinically active acromegaly.Treatment with a dopa- mine agonist inhibited prolactin secretion, which was followed by increased hypothalamic dopamine content.Release of somatostatin might then have been reduced and release of growth hormone releasing factor increased, leading to the rapid increase in growth hormone concentrations and the enlargement of the pituitary tumour. 1
Correlation of FIBROSpect II With Histologic and Morphometric Evaluation of Liver Fibrosis in Chronic Hepatitis C
Authors: Keyur Patel, David R. Nelson, Don C. Rockey, Nezam H. Afdhal, Katie M. Smith, Esther Oh, Keith Hettinger, Marc Vallée, Anouk Dev, Margaret Smith–Riggs, John G. McHutchison
Journal: Clinical Gastroenterology and Hepatology (2008)
What determines the age at the menopause?
Authors: J. McGarry
Journal: BMJ (1991)

mortalitv, is deliberately!misleading: the excess deaths were due to distant metastases.T! hese deaths were inevitable even before the patients entered the flawed trial.We know that this was the basis for the rejection of the study as totally inappropriate by the Radiation Therapy Oncology Group's fast neutron group in the US.So why waste time, precious resources, and the trust of patients?Yet Dr Errington and colleagues have persevered and delivered another antineutron headline.Such a headline might have been critical to the project to get a cyclotron where it would be used effectively for the benefit of patients.But this had already been torpedoed-after a brilliant, well orchestrated campaign-bv the withdrawal of what has been represented as the infamous Thatcher £6 million repayable loan-which was not a grant for cancer research, as is so often misreported, but a repayable loan for treatment.
An adult with common acute lymphoblastic leukaemia (C-ALL) presenting with skin infiltration
Authors: H. ABOUD, J. TRELEAVEN, R. CARTER, M. O'BRIEN, R. POWELS
Journal: British Journal of Dermatology (1991)

Journal Article An adult with common acute lymphoblastic leukaemia (C‐ALL) presenting with skin infiltration Get access H. ABOUD, H. ABOUD Department of Haematology, Royal Marsden Hospital, Downs RoadSulton, Surrey, U.K. Search for other works by this author on: Oxford Academic Google Scholar J. TRELEAVEN, J. TRELEAVEN Department of Haematology, Royal Marsden Hospital, Downs RoadSulton, Surrey, U.K. Dr J. Treleaven Search for other works by this author on: Oxford Academic Google Scholar R. CARTER, R. CARTER Department of Histopathology, Royal Marsden Hospital, Downs RoadSulton, Surrey, U.K. Search for other works by this author on: Oxford Academic Google Scholar M. O'BRIEN, M. O'BRIEN Department of Medical Oncology, Royal Marsden Hospital, Downs Road, Sulton, Surrey, U.K. Search for other works by this author on: Oxford Academic Google Scholar R. POWELS R. POWELS Department of Medical Oncology, Royal Marsden Hospital, Downs Road, Sulton, Surrey, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 124, Issue 1, 1 January 1991, Pages 84–85, https://doi.org/10.1111/j.1365-2133.1991.tb03287.x Published: 01 January 1991
An attempt at combining corticotrophin with long-term corticosteroid therapy. With a view to preserving hypothalmic-pituitary-adrenal function.
Authors: M E Carter, V H James
Journal: Annals of the Rheumatic Diseases (1970)

GROUP 1 (Cases 1 to 5) ACTH in one large dose of 80 units once a week.Prednisolone daily, mean dose 12 mg./day.GROUP 2 (Cases 2, 5, 6 to 8) ACTH in one large dose of 80 units twice weekly.Prednisolone daily, mean dose 12 mg./day.GROUP 3 (Cases 9 to 11) ACTH 1 day in 3, mean dose 30 units/day.Prednisolone on the 2 remaining days out of 3, mean dose 10 mg./day.GROUP 4 (Cases 5, 11, 12) ACTH on alternate days, mean dose 25 units/day.Prednisolone on alternate days, mean dose 6 mg./day.
Risk of Pneumococcal Infections in Renal Transplant Patients
Authors: Calvin C. Linnemann
Journal: JAMA (1979)

Because of the recent licensing of pneumococcal vaccine, the risk of pneumococcal infections on a renal transplant service was determined. The overall risk of infection was 7% (14 of 197 patients) over a six-year period, or 1% per year. In patients with functioning allografts, this represented a risk of 28 infections per 1,000 patient-years of follow-up. Clinically, the major presentations of pneumococcal infection were pneumonia in the patient who was rejecting his kidney and pneumococcemia of sudden onset that was often fatal. Five of the pneumococci isolated from bacteremic patients were typed; three of the isolates were types that are in the vaccine. The frequency and seriousness of pneumococcal infections in renal transplant patients suggest that pneumococcal vaccine should be given to these patients, probably before transplantation. (<i>JAMA</i>241:2619-2621, 1979)
One-step mini-invasive treatment of abdominal aortic-iliac aneurysm associated with colo-rectal cancer
Authors: Bruno Amato, Giovanni Esposito, Raffaele Serra, Rita Compagna, Gabriele Vigliotti, Tommaso Bianco, Guido Massa, Maurizio Amato, Salvatore Massa, Giovanni Aprea
Journal: International Journal of Surgery (2014)
Herman Boerhaave: The Man and His Work
Authors: Malcolm Nicolson
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diminutive Gastrointestinal Lesions in Cholesterol Crystal Embolization
Authors: M. Hirahashi, T. Matsumoto, M. Esaki, M. Nagata, H. Hirakata, T. Yao, M. Iida
Journal: Endoscopy (2005)

Figure 1 Cholesterol crystal embolization (CCE) is a condition characterized by systemic embolization of cholesterol crystals from atherosclerotic plaques lining in the walls of major arteries. We found diminutive gastrointestinal lesions in four of five patients with CCE. Here, livedo reticularis is seen in the foot of a 70-year-old man with CCE. A biopsy specimen from the livedo reticularis contained a cholesterol cleft in an arteliole of the upper dermis.
The Treatment of Graves Disease
Authors: Fereidoun Azizi
Journal: JAMA (1974)

<h3>To the Editor.—</h3> The authors cited the paper by Nofal et al to demonstrate the high incidence of hypothyroidism following radioactive iodine therapy, but failed to mention that in the same study the rate of thyroid hypofunction ten years after subtotal thyroidectomy was 43%. Although it is generally agreed that the incidence of hypothyroidism is higher following iodine 131 therapy than after surgery, the difference is not tremendous. Furthermore, recent study by Wood, Peterson, and Ingbar concludes that progressive impairment of thyroid function is a frequent termination of the natural history of Graves disease. Thus, untreated patients, as well as those treated with radioactive iodine administration or subtotal thyroidectomy, may develop hypothyroidism that can be adequately managed with daily administration of one tablet of a thyroid preparation. Recurrence of hyperthyroidism occurs in up to 17.2% of patients with Graves disease who undergo thyroidectomy (Hershman), while 90% of patients are cured
A SMALL EPIDEMIC OF M. GYPSEUM RINGWORM IN A PLANT NURSERY.
Authors: C. HOWARD WHITTLE
Journal: British Journal of Dermatology (1954)

Journal Article A SMALL EPIDEMIC OF M. GYPSEUM RINGWORM IN A PLANT NURSERY. Get access C. HOWARD WHITTLE C. HOWARD WHITTLE Physician to Skin Department, United Cambridge Hospitals Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 66, Issue 10, 1 October 1954, Pages 353–356, https://doi.org/10.1111/j.1365-2133.1954.tb12561.x Published: 01 October 1954
Implications for Biologic Therapy:<i>Staphylococcus aureus</i>Decolonization of Individuals With a History of Recurrent Skin and Soft-Tissue Infections
Authors: Jennifer H. Ku, Kevin L. Winthrop, Cara D. Varley, Annika Sullivan, Benjamin D. Ehst, Andrew Blauvelt, Atul A. Deodhar
Journal: JAMA Dermatology (2013)