tbuckley/cabot-search huggingface dataset:
CASES OF ANGIOMA OF SYNOVIAL MEMBRANES AND OF MUSCLE
Authors: F. Eve
Journal: BMJ (1903)

ANGIOMA OF SYNOVIAL MEMBRANES AND MUSCLE.[I IfL 1 143 seemingly dying from shock.A further hypodermic injection was given of strychnine (j,1 gr.) and digitalin (2'5 gr.), and the child placed in a tub of hot water and vigorously rubbed.The improvement, if any, was very slight.
WHO visit to China heralds closer links
Authors: A. Mach
Journal: BMJ (1998)

In her first visit to a member state of the WHO, Director General Gro Harlem Brundtland this week visited China, signalling “a revolution in the way the WHO looks at both Asia and health.”

Following her own prescription to put health higher on the political agenda, Brundtland's schedule included meetings with China's president, Jiang Zemin, and premier, Zhu Rongji, as well as with the ministers of …
Familial Hypophosphatemia
Authors: William G. Blackard, Roscoe R. Robinson, J. Earle White
Journal: New England Journal of Medicine (1962)

THE occurrence of rachitic bone changes and hypophosphatemia responding only to large doses of vitamin D was described by Albright and his associates1 in 1937 as rickets resistant to vitamin D. Its familial occurrence, first reported by Christensen2 in 1941, led to the use of the term "familial hypophosphatemia." This designation now seems more appropriate in view of the fact that some of these patients may have hypophosphatemia without evidence of rachitic changes. In addition, the resistance to vitamin D is only relative since in all reported cases the patients have eventually responded to large doses of vitamin D. Winters . . .
Dutch doctor struck off for alternative care of actor dying of cancer
Authors: Tony Sheldon
Journal: BMJ (2007)

NHS Employers, the organisation responsible for employment procedures in the NHS, defended its vetting practices this week after seven doctors and medical students-six in the United Kingdom and one in Australia-were held by police in connection with the failed car bombings in London and Glasgow.One doctor, Iraqi born Bilal Abdullah, who worked as a locum doctor at the Royal Alexandra Hospital, in Paisley, near Glasgow, was arrested at the scene of Saturday's attempt to blow up a jeep packed with gas cylinders at Glasgow airport.Another man detained at the scene with 90% burns is thought to be a junior hospital doctor.He is in the Royal Alexandra Hospital.Later that day, the 26 year old Jordanian born doctor Mohammed Asha and a 27 year old woman, thought to be his wife, were arrested in Sandbach, Cheshire, northwest England.Dr Asha, whose family comes originally from Palestine, had worked as a junior doctor at the Royal Shrewsbury Hospital and the Princess Royal Hospital, in Telford.In a statement NHS Employers said that all NHS hospitals "carry out rigorous checks before they appoint any member of staff, including verification of identity, qualifications, registration, and eligibility to work in the UK."The nature of their work means that staff are dealing with people who are vulnerable, and we need to be confident that patients are safe."It added, "While doing all they can to prevent unsuitable people taking up employment in the NHS, employers also have a duty to look after the rights of their staff, and this includes not discriminating against employees in any way on the grounds of their religion or belief." NHS defends vetting after doctors held for bombing bidsUK NEWS Economist says NICE should approve fewer costly drugs, p11 World NEWS �ost US surgeons in training get needlestic�� in�uries, few report them, p1� �ost US surgeons in training get needlestic�� in�uries, few report them, p1� , p1� bm�.comEgypt tightens ban on female genital mutilation after 1�� year old girl dies Egypt tightens ban on female genital mutilation after 1�� year old girl dies
William Harry Ruxton Auld
Authors: C. D. Auld
Journal: BMJ (2010)

Following house jobs at Aberdeen Royal Infirmary, William Harry Ruxton Auld (“Harry”) was appointed lecturer in clinical chemistry and pathology in Aberdeen. During this period he obtained MD (Hons) in 1954, and was awarded the Lund research scholarship in 1950. He was appointed consultant chemical pathologist to the Chelsea and Kensington group of hospitals in …
Development of a sensitive assay for detection of replication-competent recombinant lentivirus in large-scale HIV-based vector preparations
Authors: Paul Escarpe, Nathalie Zayek, Peggy Chin, Flavia Borellini, Romain Zufferey, Gabor Veres, Veronique Kiermer
Journal: Molecular Therapy (2003)

Lentiviral vectors have demonstrated great potential as gene therapy vectors mediating efficient ex vivo and in vivo gene delivery and long-term transgene expression in both dividing and nondividing cells. However, for clinical studies it must be demonstrated that lentiviral vector preparations are safe and not contaminated by replication-competent recombinants related to the parental pathogenic virus. Here we describe a sensitive assay for the detection of replication-competent lentiviruses (RCL) in large-scale preparations of HIV-based lentiviral vectors. This RCL assay for lentiviral vectors is based on the principles used for retroviral vectors, using a highly permissive cell line, C8166-45, for RCL amplification and an appropriate positive control virus to establish the assay sensitivity. The assay is capable of detecting 1 RCL infectious unit in a background of 2.5 x 10(8) transducing units of vector in a single test culture. Statistically representative samples from large-scale lentiviral vector productions were assayed using multiple test cultures for each lot. Overall, a total of 1.4 x 10(10) transducing units of vector from 10 independent 14-liter production lots were screened and no RCL was detected. We propose to implement this assay as a release testing for clinical-grade lentiviral vector preparations intended for gene therapy clinical trials.
Annular vasculitis associated with pregnancy
Authors: R.I. KELLY, M.G. COOK, R.A. MARSDEN
Journal: British Journal of Dermatology (1993)

A 29-year-old woman presented in the 31st week of pregnancy with an unusual bilateral, erythematous eruption on the posterior calves, which clinically resembled erythema annulare centrifugum. A biopsy showed features of a mild leucocytoclastic vasculitis. Within 2 days of delivery the rash had almost resolved, suggesting that its activity was related to the pregnancy. The diagnosis is consistent with 'annular vasculitis', which we suggest represents a distinct variant of leucocytoclastic vasculitis, and a distinct clinicopathological entity. We are not aware of any previous reports of an association between annular vasculitis and pregnancy.
An Electrophysiologic Correlate of Ouabain Inotropy in Canine Cardiac Muscle
Authors: ROBERT E. EDMANDS, KALMAN GREENSPAN, CHARLES FISCH
Journal: Circulation Research (1967)

Action potentials were recorded via intracellular microelectrodes, together with recordings of isometric-contractile tension, from isolated trabecular muscles of canine ventricle. The effects of administration of ouabain solution in concentrations varying from 1.7 x 10 -7 to 5 x 10 -4 M were recorded. The early inotropic effects of ouabain (increase in contractile force) were accompanied by changes in configuration of the action potential identical to those associated with interval-dependent potentiation in the control state, that is, abbreviation of phase 2 and lengthening of phase 3, without significant change in duration of the action potential. The progressive administration of ouabain, while associated with contractile enhancement of the regularly stimulated contraction was also accompanied by a loss of the contractile increment associated with poststimulation potentiation; this loss of interval-dependent potentiation corresponds to a loss of interval-dependent alteration of the action potential. Thus, both interval-dependent contractile potentiation and ouabain inotropy correlate consistently with phase 2 abbreviation of the accompanying action potentials.
P185 Quantification and Treatment Patterns of Real-World Patients Classified by the GOLD 2011 Strategy
Authors: M Small, S Broomfield, V Higgins
Journal: Thorax (2012)

<h3>Objectives</h3> The Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2011 Strategy classifies COPD patients into 4 categories (A: low risk, less symptoms; B: low risk, more symptoms; C: high risk, less symptoms; D: high risk, more symptoms) based on risk (FEV<sub>1</sub> ≥ or &lt;50% predicted <i>and/or</i> exacerbation history &lt; or ≥2 per year) and symptoms (COPD Assessment test [CAT] score &lt; or ≥10 <i>or</i> modified Medical Research Council [mMRC] dyspnoea scale &lt; or ≥2). We examined the proportion of patients in each category when evaluated by CAT or mMRC, and corresponding pharmacological treatment (CAT classification). <h3>Methods</h3> GOLD 2011 criteria were applied to a real-world international COPD population sampled from the Adelphi Respiratory Disease Specific. Programme undertaken between June 2011 and September 2011. Physicians and patients completed matched questionnaires. <h3>Results</h3> 2392 patients completed a questionnaire, of which 1508 with all 4 GOLD classification parameters were analyzed. The proportion of patients in categories A, B, C and D, respectively, when evaluated by CAT was 10, 49, 1 and 40%, and when evaluated by mMRC was 39, 20, 13 and 28%. By CAT evaluation in categories A, B, C, and D, patients were using a long-acting β2-agonist (LABA) alone (8, 6, 0 and 1%), long-acting muscarinic antagonist (LAMA) alone (37, 25, 8 and 5%), inhaled corticosteroid plus LABA (ICS/LABA) alone (22, 18, 8 and 8%), and ICS/LABA plus LAMA only (11, 20, 46, 43%). <h3>Conclusion</h3> CAT assessment increased the number of patients in the more symptomatic categories (B and D), compared with mMRC. Contrary to the GOLD 2011 recommendations, by CAT assessment, a high proportion of low-risk patients (A and B) were using ICS/LABA.
Thrombocytosis Associated with Low-Molecular-Weight Heparin
Authors: Eliot Williams
Journal: Annals of Internal Medicine (1997)

Letters1 May 1997Thrombocytosis Associated with Low-Molecular-Weight HeparinEliot Williams, MD, PhDEliot Williams, MD, PhDUniversity of Wisconsin, Madison, WI 53792Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-126-9-199705010-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Rizzieri and coworkers [1] report a case of thrombocytosis that they attribute to treatment with enoxaparin. The patient had metastatic carcinoma and was asplenic; enoxaparin was given for pulmonary embolism. The platelet count was normal (285 cells/mm3) before enoxaparin treatment, increased to 1114 cells/mm3 within 4 weeks of treatment, and became normal after chemotherapy for carcinoma and discontinuation of enoxaparin therapy. I propose an alternate explanation for these findings. I suspect that the patient had the Trousseau syndrome with disseminated intravascular coagulation and rapid platelet consumption. A platelet count of more than 1 million cells/mm3 could result ...References1. Rizzieri DA, Wong WM, Gockerman JP. Thrombocytosis associated with low-molecular-weight heparin [Letter]. Ann Intern Med. 1996; 125:157. Google Scholar2. Buss DH, Cashell AW, O'Connor ML, Richards F, Case LD. Occurrence, etiology, and clinical significance of extreme thrombocytosis: a study of 280 cases. Am J Med. 1994; 96:247-53. Google Scholar Author, Article, and Disclosure InformationAuthors: Eliot Williams, MD, PhDAffiliations: University of Wisconsin, Madison, WI 53792 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThrombocytosisLa thrombocytose au cours des traitements par héparine de bas poids moléculaire : une situation plus fréquente qu’on ne le croit ?Reactive Thrombocytosis Associated with EnoxaparinUtilisation and Safety of Low Molecular Weight HeparinsSubcutaneous fat necrosis associated with thrombocytosis in an infant following cardiac surgery 1 May 1997Volume 126, Issue 9Page: 742KeywordsChemotherapyDisseminated intravascular coagulationDrugsLow molecular weight heparinPlateletsPulmonary embolismThrombocytosis ePublished: 15 August 2000 Issue Published: 1 May 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Management of Frey's Syndrome
Authors: James C. Erickson
Journal: JAMA (1985)

<h3>To the Editor.—</h3> The QUESTIONS AND ANSWERS section regarding Frey's syndrome inThe Journal<sup>1</sup>brought to light another rarely encountered automatic dysfunction. The profuse unilateral facial sweating response to gustatory stimulation may indeed become milder with passage of time, but the victim of such a distressing situation may perceive it as being endless. Topical applications of 20% aluminum chloride in an alcohol solution as recommended by Dr K. Sato may provide significant relief, but his comments suggest only brief improvement and imply the need for daily treatments. When we administer stellate ganglion blocks, usually for reflex sympathetic dystrophy or causalgia of an upper extremity, we observe the development of a Horner's syndrome, consisting of unilateral dryness of the face, stuffiness of the nostril, and miosis. The beneficial pain relief usually lasts beyond the pharmacologic duration of the local anesthetic and when a series of sympathetic blocks is administered, the
ATROPHY OF THE RETINA.
Authors: DUDLEY S. REYNOLDS
Journal: JAMA (1901)

It may be sometimes quite impossible to discover the cause of disease, and it is not always easy to determine whether a lesion is dependent upon some other morbid process, or of primary origin. I have hesitated to believe it possible for atrophy of the retina to come on as a primary condition, without any discoverable preceding inflammation, or even hyperplasia; but, it is certain that, whatever disturbances may have preceded the beginning of atrophic changes in the two cases herein reported, there was no manifest hyperemia before failure of sight. I am not sure that some occult inhibition of the functions of the vasomotor nerve force may not cause primary atrophy. Miss M. B. J., aged 19, came to me July 12, 1882, with a note explaining that she had been unable to pursue her studies without headache. After suspending her accommodation, I found that, with +1/30 C. ax.
Cancer stem cells: therapeutic implications and perspectives in cancer therapy
Authors: Lu Han, Sanjun Shi, Tao Gong, Zhirong Zhang, Xun Sun
Journal: Acta Pharmaceutica Sinica B (2013)

The cancer stem cell (CSC) theory is gaining increasing attention from researchers and has become an important focus of cancer research. According to the theory, a minority population of cancer cells is capable of self-renewal and generation of differentiated progeny, termed cancer stem cells (CSCs). Understanding the properties and characteristics of CSCs is key to future study on cancer research, such as the isolation and identification of CSCs, the cancer diagnosis, and the cancer therapy. Standard oncology treatments, such as chemotherapy, radiotherapy and surgical resection, can only shrink the bulk tumor and the tumor tends to relapse. Thus, therapeutic strategies that focus on targeting CSCs and their microenvironmental niche address the ineffectiveness of traditional cancer therapies to eradicate the CSCs that otherwise result in therapy resistance. The combined use of traditional therapies with targeted CSC-specific agents may target the whole cancer and offer a promising strategy for lasting treatment and even cure.
Renal Pathophysiology: Recent Advances
Authors: Benjamin H. Spargo
Journal: JAMA (1980)

This 281-page volume represents the proceedings of a symposium on advances in renal pathology, immunology, and physiology, held in January 1979. It is intended to update areas of nephrological investigation for both clinicians and researchers involved in renal disease. The chapters, by authors on both sides of the Atlantic, are divided into seven sections: immunologic aspects of kidney diseases, the glomerulus, interstitial disease, tubular transport, renal hemodynamics, and disease models. Five others deal with various topics that were apparently not part of the original symposium. As might be expected of a book of this type, the quality of the contributions varies. The section on interstitial diseases, for example, deals with general and drug-related causes of interstitial nephritis and the predictability of functional changes based on interstitial changes present in a renal biopsy specimen. Little of the information in this section is new, and much is already present in textbooks of
MEDICAL DIATHERMY IN KIDNEY DISEASES
Authors: GUSTAV KOLISCHER
Journal: JAMA (1926)

Medical diathermy, the heating within physiologic limits of bodily structures with high frequency currents, may be employed to advantage in glomerulonephritis and toxic nephrosis.  The efficiency of this therapeutic procedure depends on its judicious application according to the character of the case. Glomerulonephritis, whose essential feature is the more or less complete blockade of the glomeruli involved and the subsequent renal ischemia, is a condition in which the local administration of high frequency currents to the diseased kidney or kidneys may be beneficial. The heating causes the arteries, arterioles and capillaries within the area under the influence of the high frequency current to dilate, and is therefore apt to improve the impaired circulation. The clinical effect of this active hyperemia is readily observed. Following the diathermic treatment, the urinary output is raised; the content in the urine of liquid blood is promptly heightened, and the number of tiny coagula appearing
Effect of intravenous terbutaline on arterial blood gas tensions, ventilation, and pulmonary circulation in patients with chronic bronchitis and cor pulmonale.
Authors: R A Stockley, P Finnegan, J M Bishop
Journal: Thorax (1977)

Terbutaline sulphate was given intravenously to 10 patients with pulmonary vascular disease secondary to chronic hypoxia. The resting cardiac index increased after terbutaline in all the patients between 5 and 74% above the control level. The greatest change was seen in patients who had received the largest total dose. The rise in cardiac index was associated with a fall in pulmonary vascular resistance although mean pulmonary artery pressure remained unaltered. There was a significant increase in the venous admixture but this did not adversely affect the arterial oxygen tension. The peak expiratory flow rate did not change significantly but there was an increase in ventilation from a mean value of 4.36 1/min/m2 to 4.67 1/min/m2. The results show that terbutaline has little adverse effect on the pulmonary circulation or gas exchange in patients with irreversible airways disease who are in a stable state.
Increased risk of incident HIV during pregnancy in Rakai, Uganda: a prospective study
Authors: Ronald H Gray, Xianbin Li, Godfrey Kigozi, David Serwadda, Heena Brahmbhatt, Fred Wabwire-Mangen, Fred Nalugoda, Mohamed Kiddugavu, Nelson Sewankambo, Thomas C Quinn, Steven J Reynolds, Maria J Wawer
Journal: The Lancet (2005)
Alterations in cytotoxic and helper T cell function after infection of T cell clones with human T cell leukemia virus, type I.
Authors: R Yarchoan, H G Guo, M Reitz, A Maluish, H Mitsuya, S Broder
Journal: Journal of Clinical Investigation (1986)

HTLV-I is a transforming human retrovirus that is an etiologic agent of adult T cell leukemia/lymphoma. To investigate the effects of this virus on T cell functions, two OKT3+, OKT4+, OKT8- cytotoxic clones (8.7 and 8.8) specific for allogeneic cells bearing DPw2, a class II histocompatibility antigen, were studied before and after infection with HTLV-I. The clones retained cytotoxic function for up to 70 d after exposure to HTLV-I, even without subsequent antigenic stimulation, but then lost their cytotoxic activity. Prior to infection with HTLV-I, clone 8.8 also lysed OKT3 hybridoma cells; after infection, cytotoxic activity against these OKT3-antibody bearing cells was lost in parallel with the loss of activity against DPw2-bearing target cells. In addition, expression of T3 surface antigen by HTLV-I-infected 8.8 cells was decreased at a time when they lost their cytotoxic activity, possibly contributing to the loss of cytotoxic function. Finally, clone 8.8 could provide help for nonspecific IgG production by autologous B cells when stimulated with irradiated DPw2-bearing non-T cells. After infection with HTLV-I, this helper function became independent of DPw2-stimulation and persisted even when the cytotoxic activity was lost. An OKT4+ T cell clone thus could simultaneously manifest both cytotoxic and helper T cell activities, and these activities were differentially affected after HTLV-I infection.
Ethnic Minority Health: A Selected, Annotated Bibliography
Authors: James Shedlock
Journal: Annals of Internal Medicine (1997)

Medical Writings15 October 1997Ethnic Minority Health: A Selected, Annotated BibliographyJames Shedlock, AMLSJames Shedlock, AMLSNorthwestern University, Chicago, IllinoisSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-8_Part_1-199710150-00039 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Haynes C. 503 pages. Lanham, MD: Scarecrow Pr; 1997.$65.00. ISBN 0810832259. Order phone 800-462-6420.Field of medicine: Library and information science.Format: Hardcover book.Audience: Students of ethnic minority health.Purpose: To assist with research, data identification, education, and training with respect to disparity in the health status of ethnic minorities, a significant issue for U.S. society.Content: This bibliography addresses ethnic minority health from 1970 to 1995. Emphasis is on selective monographs dealing with four populations: Native Americans and Alaska Natives, African Americans, Asian Americans and Pacific Islanders, and Hispanics. Monographic literature comprises 60% of the entries; the ... Author, Article, and Disclosure InformationAffiliations: Northwestern University, Chicago, Illinois PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 October 1997Volume 127, Issue 8_Part_1Page: 659-660 ePublished: 15 August 2000 Issue Published: 15 October 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Predictors of survival after aortic valve replacement in patients with low‐flow and high‐gradient aortic stenosis
Authors: Wen‐Hong Ding, Yat‐Yin Lam, Alison Duncan, Wei Li, Eric Lim, Mehmet G. Kaya, Robin Chung, John R. Pepper, Michael Y. Henein
Journal: European Journal of Heart Failure (2009)