tbuckley/cabot-search huggingface dataset:
Brain feedback and adaptive resonance in speech perception
Authors: Stephen Grossberg
Journal: Behavioral and Brain Sciences (2000)

The brain contains ubiquitous reciprocal bottom-up and top-down intercortical and thalamocortical pathways. These resonating feedback pathways may be essential for stable learning of speech and language codes and for context-sensitive selection and completion of noisy speech sounds and word groupings. Context-sensitive speech data, notably interword backward effects in time, have been quantitatively modeled using these concepts but not with purely feedforward models.
The Self-Help Sourcebook: Finding and Forming Mutual Aid Self-Help Groups
Authors: Hannah L. Hedrick
Journal: JAMA (1995)

<b>Redefining Self-Help: Policy and Practice,</b>by Frank Riessman and David Carroll, 220 pp, paper, $29.95, ISBN O-7879-0066-4, San Francisco, Calif, Jossey-Bass Publishers, 1995. <b>Understanding the Self-Help Organization: Frameworks and Findings,</b>edited by Thomas J. Powell, 345 pp, $52, ISBN 0-8039-5487-5, paper, $24.95, ISBN 0-8039-5488-3, Thousand Oaks, Calif, Sage Publications, 1994. <b>Self-Help and Mutual Aid Groups: International and Multicultural Perspectives,</b>edited by Francine Lavoie, Thomasina Borkman, and Benjamin Gidron (conference, Ottawa, Ontario, September 1992), 363 pp, $49.95, ISBN 1-56024-716-9, paper, $24.95, Binghamton, NY, The Haworth Press, 1995. As hospital stays are reduced for everyone from new mothers and babies to seniors with multiple health problems, physicians and their staffs are turning to community resources to assist their patients. Self-help groups are among these resources. Physicians have long referred patients to 12-step and other peer-support programs for recovery from substance abuse. Since C. Everett Koop, MD, sponsored his Surgeon General's Workshop on
Gastroprotective Therapy Does Not Improve Outcomes of Patients With Helicobacter pylori–Negative Idiopathic Bleeding Ulcers
Authors: Grace Lai–Hung Wong, Kim Wing–Lam Au, Angeline Oi–Shan Lo, Yee–Kit Tse, Jessica Yuet–Ling Ching, Ka–Fai To, Francis Ka–Leung Chan
Journal: Clinical Gastroenterology and Hepatology (2012)
Characteristics of RNA degradation in the erythroid cell
Authors: Edward R. Burka
Journal: Journal of Clinical Investigation (1969)

The characteristics of ribonucleic acid (RNA) degradation in intact reticulocytes have been investigated. The rate of degradation during in vitro maturation at 37°C is approximately 4% per hr. RNA degradation does not proceed at 0°C, and the rate of degradation is temperature dependent with an optimum at 50°C. The process is not dependent upon glycolysis. Although all types of RNA progressively decrease during in vivo maturation, ribosomes are degraded at a rate greater than that of soluble RNA.
Parenterally Transmitted Non-A, Non-B Hepatitis
Authors: J D Meyers, J L Dienstag, R H Purcell, E D Thomas, K K Holmes
Journal: Annals of Internal Medicine (1977)

In 1972 a nosocomial outbreak of parenterally transmitted hepatitis affected both marrow transplant patients and normal platelet donors in an oncology unit. Because of the characteristics of the clinical illness, the incubation period of 27 days, and the effect of immune serum globulin on the clinical illness, the outbreak was attributed to hepatitis A; there was no serologic evidence of either hepatitis B virus or cytomegalovirus infection. Stored serums from this outbreak were re-examined by more recently developed serologic techniques for evidence of hepatitis A (HA) virus infection. Ten patients and donors had undetectable anti-HA titers before illness and none seroconverted; five persons had pre-existent anti-HA titers and showed no further rise in convalescent serums. The serum of one patient was inevaluable. With the availability of serologic techniques for the diagnosis of both hepatitis A and hepatitis B virus infections, it is clear that most cases of post-transfusion hepatitis are not due to either of these agents, and short-incubation-period hepatitis can not be assumed to be hepatitis A without further investigation.
Medicare Requirement for Research Participation
Authors: Mayer Brezis, Lisa Soleymani Lehmann
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Progressive dyspnoea, pleural effusions and lytic bone lesions
Authors: A G Nicholson, E Anderson, S Saha, M Indrajith, B Conry, J Hughes
Journal: Thorax (2008)

A 72-year-old man was referred following a CT scan which showed lytic and sclerotic lesions in the spine and pelvis with bilateral pleural effusions and thickening. The patient was an ex-smoker with progressive dyspnoea and significant weight loss over 1 year. There was no history …
Elective End-to-side Portacaval Shunt: Results in 64 Cases
Authors: K. Hourigan, S. Sherlock, P. George, S. Mindel
Journal: BMJ (1971)

In a series of 64 cases of elective end-to-side portacaval shunts performed for liver disease the success rate-in that the patient survived with a patent shunt, free of subsequent haemorrhage and severe encephalopathy-was 48%.The early postoperative death rate was 12.5% and the five-year survival 65%. Bleeding from oesophagogastric varices after blockage of the shunt was responsible for at least half of the early postoperative deaths, and most late deaths were due to liver failure. A decreased chance of late survival was associated with age over 40 years, active chronic hepatitis, and with a preoperative history of hepatocellular jaundice.Shunt blockage occurred in 16% of patients, and all bled again from oesophagogastric varices. Shunt block is more likely if the portal vein is calcified or thrombosed, and may be more likely if the portal vein diameter, as shown by splenic venography, is 1.5 cm or less.In survivors with a patent shunt the most serious late complication was chronic, severe portal-systemic encephalopathy, which occurred in 38%. Severe encephalopathy was associated with age over 40 years, a preoperative history of any degree of encephalopathy, diabetes mellitus, and with continued drinking in the alcoholic. Most patients who had portal-systemic encephalopathy in the first year postoperatively developed chronic disabling encephalopathy.A preoperative history of transient mild or moderate ascites did not seem adversely to influence the outcome.
Left Ventricular Wall Motion During the Isovolumic Relaxation Period
Authors: PABLO I. ALTIERI, SHARON M. WILT, RICHARD F. LEIGHTON
Journal: Circulation (1973)

Technically adequate left ventricular cineangiograms obtained in the 30 degree right anterior oblique (RAO) projection from 100 consecutive patients with chest pain were studied for the presence of left ventricular wall motion during the isovolumic relaxation period. Obstructive coronary artery disease was found in 59 and normal coronary arteries in 41 patients. Systolic contraction abnormalities were present in 52 of the 100 patients. Outward left ventricular wall motion during the isovolumic relaxation period was observed in 83 patients. This outward motion, termed segmental early relaxation phenomenon (SERP), was localized in 81. In 29 patients SERP was accompanied by a simultaneous inward motion that was apparent in the 30 degree RAO position in another part of the left ventricle. In ventricles with systolic contraction abnormalities SERP tended to occur in the normally contracting areas (25 of 39 patients). When the abnormal systolic contraction was extensive, SERP occurred infrequently (4 of 16 patients). In this group of patients with chest pain, whether or not they had coronary artery disease, outward left ventricular wall motion occurred commonly during isovolumic relaxation. It appears to be a normal variation of left ventricular relaxation.
UK experts will speed up work on cannabis
Authors: J. Warden
Journal: BMJ (1998)

Research into the clinical use of cannabinoids is to be put on to a new basis in Britain with the formation of a committee of experts who will draw up guidelines for good practice. The working party on the therapeutic uses of cannabinoids is being set up by the Royal Pharmaceutical Society of Great Britain and will be headed by Sir William Asscher, a former chairman of the government Committee on Safety of Medicines.

The aim is that the guidelines will encourage the Home Office to approve research licences which are currently being delayed. The development was reported by BMA …
Electron microscope study of myocardial tissue space contents in rat heart
Authors: H. MELAX, T. S. LEESON
Journal: Cardiovascular Research (1972)

The tissue space of rat cardiac muscle is continuous with the subendocardial layer and with that of the epicardium. It is bounded by the sarcolemma of myocardial fibres. The spaces between the myocardial fibres are of varying dimensions. The largest areas are probably those associated with the sinoatrial and atrioventricular nodes. The extracellular material of the myocardial tissue space generally is electron-lucent. Native collagen is present as single unit fibrils or in bundles of several unit fibrils. Elastic lamellae are present only at the aortic junction. Fibroblasts are the commonest free cells in the tissue space, and 'myocardial foam cells.' Myelinated and unmyelinated nerve fibres are numerous and are found in close association with the myocardial fibres and the extensive capillary network.
Role of acute phase reactants and infection as predictors for major adverse clinical events and angina pectoris after percutaneous coronary intervention
Authors: Braim M. Rahel, Rob J. Diepersloot, Bartelt M. de Jongh, Frank Visseren, Johannes C. Kelder, Maarten-Jan Suttorp, Thijs W. Plokker
Journal: Journal of the American College of Cardiology (2002)
25 Years of Community Cancer Center Care
Authors: Charles Marwick
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Use of non-orthodox and conventional health care in Great Britain.
Authors: K J Thomas, J Carr, L Westlake, B T Williams
Journal: BMJ (1991)

OBJECTIVE--To describe the characteristics of patients using non-orthodox health care and their pattern of use of conventional health care with respect to a particular problem. DESIGN--Postal survey of all 2152 practitioners of acupuncture, chiropractic, homeopathy, naturopathy, and osteopathy identified from 11 national professional association registers. Patients attending a representative sample of 101 responding practitioners completed questionnaires covering demographic characteristics, presenting problems, and use of the health service. SETTING--Practices of practitioners of non-orthodox health care in England, Scotland, and Wales. SUBJECTS--Qualified, non-medical practitioners of non-orthodox health care working in Great Britain and 2473 patients who had attended one of the sampled practitioners in an allocated time period between August 1987 and July 1988. RESULTS--An estimated 1909 practitioners were actively practising one of the study treatments in Great Britain in 1987. Of the estimated 70,600 patients seen by this group of practitioners in an average week, most (78%) were attending with a musculoskeletal problem. Two thirds of the patients were women. Only 2% were aged under 16, but 15% were aged 65 or over. One in three patients had not received previous conventional care for their main problem; 18% were receiving concurrent non-orthodox and conventional care. Twenty two per cent of the patients reported having seen their general practitioner for any reason in the two weeks before the surveyed consultation. CONCLUSIONS--Patients of non-orthodox health care, as provided by this group of practitioners, had not turned their backs on conventional health care. Non-orthodox treatment was sought for a limited range of problems and used most frequently as a supplement to orthodox medicine.
Prevalence of occupational allergy to <i>Chrysanthemum</i> pollen in greenhouses in the Netherlands
Authors: G. C. M. Groenewoud, N. W. De Jong, A. Burdorf, H. De Groot, R. Gerth Van Wÿk
Journal: Allergy (2002)

Background: An increasing number of allergic complaints appear to have occurred among Chrysanthemum greenhouse employees. The aim of this study was to estimate the prevalence of work‐related allergic symptoms and the prevalence of sensitization to pollen of different members of the Chrysanthemum family. Methods: We studied 104 employees who were invited to answer an extensive questionnaire and to complete a rhinitis quality of life questionnaire. In addition, they were skin prick tested on location with inhalant allergens and home‐made pollen extracts of seven different members of the Chrysanthemum family. Radio‐allergo‐sorbent tests were performed to confirm IgE‐mediated reactions. Results: Work‐related symptoms were reported in 56.7% of all cases, with the main symptom being rhinitis. Sensitization to Chrysanthemum pollen was found in 20.2% of the employees without one member of the Chrysanthemum family in particular being most prevalent. Sensitization to Chrysanthemum pollen was considered to be an important risk factor for the occurrence of work‐related symptoms of the upper airways. Furthermore, inhalant atopy as well as sensitization to common airborne pollen including mugwort were closely associated with sensitization to Chrysanthemum what might be suggestive for cross‐sensitization. Conclusions: There is a high prevalence of work‐related symptoms in Chrysanthemum greenhouses. In one‐third of the employees these symptoms were caused by an IgE‐mediated allergy caused by the pollen of the flowers. Inhalant atopy appeared to have a great impact on the development of such a sensitization. Measurements to reduce the pollen exposure are necessary to prevent a further increase of this occupational allergy.
Solitary Fibrous Tumor of the Sella Mimicking Pituitary Adenoma: An Uncommon Tumor in a Rare Location—A Case Report
Authors: Tania Weber Furlanetto, Cláudio Faria Pitta Pinheiro, Paulo Petry Oppitz, Luiz Carlos de Alencastro, Sylvia L. Asa
Journal: Endocrine Pathology (2009)
Teaching Diabetic Patients About Self-Management
Authors: Sue Judd, P H Sönksen
Journal: Diabetes Care (1980)

It takes approximately 20 min to teach a patient how to use Dextrostix reagent strips in conjunction with an Eyetone reflectance meter (or the more recently introduced Glucochek). Blood glucose monitoring is no more difficult or time consuming than conventional urine testing and can be learned and executed by patients of various levels of intelligence. It is important to emphasize the need for an adequate drop of blood and the use of Monolet blood lancets has greatly facilitated this. Emphasis is put on the most useful times to make recordings and the importance of good record-keeping. The more intelligent patients readily learn how to adjust their insulin to improve their blood glucose readings while the less intelligent need help and advice. Experience has shown that no only are blood glucose levels improved but also hypoglycemic episodes are less commmon.
Abstract 3616: Validation and fitness testing of a quantitative immunoassay for HIF1α in biopsy specimens
Authors: Sook Ryun Park, Robert J. Kinders, Sonny Khin, Melinda Hollingshead, Ralph E. Parchment, Joseph E. Tomaszewski, James H. Doroshow
Journal: Cancer Research (2012)

Abstract HIF1α is an important marker of hypoxia in human tumors that is altered in a number of cancers, but a reproducible method to determine changes in HIF1α protein expression in human tumor biopsy specimens has not been available. While HIF1α is being used as a pharmacodynamic marker in clinical trials in the NCI (CTEP# 8610, 8856, 8880), an important limitation in measuring the change in HIF1α induced by cancer therapeutic agents is the lability of the protein, in the presence of oxygen, upon collection of the sample. We have devised a method of specimen collection, handling, and extraction that preserves and stabilizes HIF1α levels in tumor biopsies. Degassed collection buffer yielded a significant increase of recovered HIF1α levels compared to the standard method of flash-freezing. The addition of 2-hydroxyglutarate, an inhibitor of prolyl hydroxylase domain enzyme that is involved in the degradation pathway of HIF1α under normoxic conditions, to the collection buffer showed a trend for improved yield of the HIF1α recovery. Sonication and homogenization with ceramic beads were superior to homogenization with metallic beads or tissue grinding. Employing this specimen-handling method allowed validation of a two-site immunoassay for HIF1α quantitation in solid-tissue extracts generated from tumor biopsies. Intra-assay variability was less than 10%, and inter-assay variability was less than 20%. Accuracy, assessed by spike recovery, was 99 +/− 7%. HIF1α readings declined linearly with decreasing sample load over a range of 1 to 10 µg protein per well. Fitness for purpose was demonstrated by quantifying a reduction in HIF1α protein levels following topotecan or indenoisoquinoline NSC 743400 treatment in an A375 xenograft model, followed by assessment of other xenograft models. HIF1α was also demonstrated to be upregulated under low oxygen tension culture conditions in DU145 human prostate cancer cells. Funded by NCI Contract No. HHSN261200800001E. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3616. doi:1538-7445.AM2012-3616
Patients Who Flirt With Treatment: The Silent Population
Authors: ROGER L. GOULD, IRENE PAULSON, LOUISE DANIELS-EPPS
Journal: American Journal of Psychiatry (1970)

The authors conducted a study of people who call psychiatric clinics for help but fail to appear for appointments. Those with the most clearly defined reasons for seeking help tend to show up, while those with the vaguest reasons tend not to. The authors suggest that those who fail to follow through are possibly in greater need than those who do not. They recommend some simple clinic policy changes that can reduce the "no-show" problem.
The Future of Generalism in Medicine
Authors: C. Anderson Hedberg
Journal: Annals of Internal Medicine (2005)

Letters1 November 2005The Future of Generalism in MedicineC. Anderson Hedberg, MDC. Anderson Hedberg, MDFrom the American College of Physicians, Philadelphia, PA 19106.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-143-9-200511010-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:As Dr. Ross points out, the need for reform of the dysfunctional payment system is key to supporting vital services provided by specialists in general internal medicine. There has been a large amount of activity at the College's Washington office in advocating on behalf of our membership and primary care; some recent examples of public statements, position papers, and other activities toward this objective are available on the College's Web site (1-5).The College is very active on Capitol Hill and continues to be directly engaged in discussions with key members of the legislative staff in the Senate ...References1. American College of Physicians. Patient-Centered, Physician-Guided Care for the Chronically Ill: The American College of Physicians Prescription for Change. 2004. Accessed at www.acponline.org/hpp/patcen_chronill.pdf on 13 July 2005. Google Scholar2. American College of Physicians. The State of the Nation's Health Care. 2005. Accessed at www.acponline.org/hpp/state_nation05.pdf on 13 July 2005. Google Scholar3. American College of Physicians. Statement for the Record of the Hearing on Measuring Quality and Efficiency of Care in Medicare, Committee on Ways and Means Subcommittee on Health. 2005. Accessed at www.acponline.org/hpp/improve_med.pdf on 13 July 2005. Google Scholar4. Doherty RB. Politics call for a compromise in tactics, not principles. ACP Observer. June 2005. Accessed at www.acponline.org/journals/news/jun05/washington.htm on 13 July 2005. Google Scholar5. American College of Physicians. The Revitalization of Internal Medicine Initiative. 2005. Accessed at www.acponline.org/revitalization on 13 July 2005. Google Scholar Author, Article, and Disclosure InformationAffiliations: From the American College of Physicians, Philadelphia, PA 19106.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoPrimary Care, Generalism, Public Good: Déjà vu? Again! Eric B. Larson , Kenneth B. Roberts , and Kevin Grumbach The Future of Generalism in Medicine Glenn S. Ross Metrics 1 November 2005Volume 143, Issue 9Page: 693KeywordsConflicts of interestForecastingHealth care qualityHealth information technology ePublished: 1 November 2005 Issue Published: 1 November 2005 CopyrightCopyright © 2005 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...