Effect of Diazoxide on Plasma Renin Activity in Hypertensive Patients
Authors: OTO KÜCHEL
Journal: Annals of Internal Medicine (1967)

Article1 October 1967Effect of Diazoxide on Plasma Renin Activity in Hypertensive PatientsOTO KÜCHEL, M.D., SC.D., LAWRENCE M. FISHMAN, M.D., GRANT W. LIDDLE, M.D., F.A.C.P., ANDREW MICHELAKIS, M.D., PH.D.OTO KÜCHEL, M.D., SC.D., LAWRENCE M. FISHMAN, M.D., GRANT W. LIDDLE, M.D., F.A.C.P., ANDREW MICHELAKIS, M.D., PH.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-4-791 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSuppression of renin production is a characteristic of primary aldosteronism; therefore, measurement of plasma renin activity has been proposed as a procedure for screening hypertensive patients for this disorder. In using plasma renin levels to distinguish primary aldosteronism from other hypertensive diseases, Conn, Cohen, Rovner, and Nesbit (1) have recommended that patients receive low-sodium diets for several days and then assume upright posture for several hours before obtaining the crucial blood sample. In normal subjects sodium depletion and upright posture both stimulate renin production. In patients with primary aldosteronism, however, plasma renin activity remains relatively low despite the application of...References1. CONNCOHENROVNERNESBIT JWELDRRM: Normokalemic primary aldosteronism. A detectable cause of curable "essential" hypertension. JAMA 193: 200, 1965. CrossrefMedlineGoogle Scholar2. SKINNERMCCUBBINPACE SLJWIH: Control of renin secretion. Circ. Res. 15: 64, 1964. CrossrefMedlineGoogle Scholar3. RUBINROTHTAYLORROSENKILDE AAFERMH: Pharmacology of diazoxide, an antihypertensive, nondiuretic benzothiadiazine. J. Pharmacol. Exp. Ther. 136: 344, 1962. MedlineGoogle Scholar4. 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FAJANSFLOYDKNOPFRULLGUNTSCHECONN SSJCRFJEMJW: Benzothiadiazine suppression of insulin release from normal and abnormal islet tissue in man. J. Clin. Invest. 45: 481, 1966. CrossrefMedlineGoogle Scholar22. KAESSSENFTLOSERTSITTSCHULTZ HGWRG: Mechanismus der gesteigerten glykogenolytischen Wirkung des Diazoxids im Kaliummangel. Naunyn Schmiedeberg. Arch. Exp. Path. 253: 395, 1966. CrossrefMedlineGoogle Scholar23. CONN JW: Hypertension, the potassium ion and impaired carbohydrate tolerance. New Eng. J. Med. 273: 1135, 1965. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From the Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tenn.This study was supported in part by grants 5-RO1-AM-05318, T1-AM-5092, 8-MO1-FR-95, and 5-K6-AM-3782, National Institutes of Health, Bethesda, Md.This paper was presented in part at the Eastern Sectional Meeting of the American Federation for Clinical Research, New York, N. Y., December 10, 1966.Requests for reprints should be addressed to Grant W. Liddle, M.D., Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tenn. 37203. 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II. Effect on the response of plasma catecholamines and plasma renin activity to insulin-induced hypoglycemiaADRENAL STEROIDOGENESIS IN "LOW RENIN" OR HYPORENINEMIC HYPERTENSIONThe Adrenal Cortex and Essential HypertensionThe stimulation of renin secretion by diazoxide in the isolated rat kidneyAdrenal steroidogenesis in "low renin" or hyporeninemic hypertensionWhen to Measure ReninHypertension corrected by discontinuing chronic sodium bicarbonate ingestionEffect of High Dose Spironolactone and Chlorthalidone in Essential Hypertension: Relation to Plasma Renin Activity and Plasma VolumeStimulated Renin: A Screening Test for HypertensionLAWRENCE WALLACH, M.D., ILDIKO NYARAI, KEITH G. DAWSON, M.D., Ph.D., F.A.C.P., F.R.C.P. (C)Der Effekt einer akuten Blutdrucksenkung durch Diazoxid auf die Nierenfunktion hydrierter HypertonikerLOW-RENIN HYPERTENSION : NEPHROSCLEROSIS ?The pharmacologic basis of antihypertensive therapy: The role of vasodilator drugsThe Renin-Angiotensin SystemLow-renin hypertensionSurgery and the Adrenal CortexTHE EFFECT OF PROPRANOLOL ON PLASMA RENIN ACTIVITY AND BLOOD PRESSURE IN MILD ESSENTIAL HYPERTENSIONPrimary Aldosteronism: Importance of the Level of Plasma Renin as an Adjunct in DiagnosisNebennierenrinde und HochdruckDissociation of dipsogenic and depressor responses produced by hypotensive agentsReninaktivit�t im Nierenvenenblut und ihre Stimulierbarkeit durch Hydralazin und TheophyllinRenin as a risk factor in essential hypertension: More evidenceNeurogenic factors in human hypertension: Mechanism or myth?Correlation of pathophysiology and pharmacotherapy in primary hypertensionLACK OF ASSOCIATION BETWEEN PLASMA-RENIN AND HISTORY OF HEART-ATTACK OR STROKE IN PATIENTS WITH ESSENTIAL HYPERTENSIONMinoxidil — An Alternative to Nephrectomy for Refractory HypertensionAdrenergic Component of Renin Release Induced by Vasodilating Antihypertensive Drugs in the RatReferencesReninaktivität im Nierenvenenblut und ihre Stimulierbarkeit durch verschiedene PharmakaLow Renin Hypertension and the Adrenal CortexSevere polydipsia and antidiuresis produced by diazoxideNiere und HochdruckZur Reagibilit�t des Renin-Angiotensin-Systems bei kardialer Hydropsie: Hinweise auf eine vom Gesamtnatriumbestand abh�ngige Regulation der ReninfreisetzungLow Plasma Renin in Hypertensive Patients: Correlations with Aldosterone, Sodium and Potassium ExcretionStudies on the Mechanism of Renin Suppression by Alpha-MethyldopaParadoxical Response of Plasma Renin Activity to Change in Sodium Intake in Hypertensive PatientsMineralocorticoidsyndromeHypertension and Low Plasma Renin Activity: Presumptive Evidence for Mineralocorticoid ExcessRICHARD F. SPARK, M.D., F.A.C.P., JAMES C. MELBY, M.D., F.A.C.P.Renin in differential diagnosis of hypertensionDie Bedeutung des sympathico-adrenalen Systems f�r die ReninfreisetzungThe pattern of plasma renin activity and aldosterone secretion in normal and hypertensive subjects before and after saline infusionsThe pattern of electrolyte excretion in normal and hypertensive subjects before and after saline infusionsDetermination of Plasma Renin Concentration by Angiotensin I ImmunoassayHypermineralocorticoidismus und HypertonieREFERENCESThe Relationship between Angiotensin and AldosteroneHypertension, Adrenal Abnormalities, and Alterations in Plasma Renin ActivityJ. CAULlE GUNNELLS JR., M.D., F.A.C.P., W. L. MCGUFFIN JR., M.D., R. R. ROBINSON, M.D., F.A.C.P., C. E. GRIM, M.D., SAMUEL WELLS, M.D., DONALD SILVER, M.D., J. F. GLENN, M.D.Hypertension and Severe Hyperkalaemia Associated with Suppression of Renin and Aldosterone and Completely Reversed by Dietary Sodium RestrictionPlasmareninaktivit�t nach Orthostase und nach Diazoxid bei prim�rer und renaler HypertonieIncreased plasma renin activity induced in rats by physostigmine and effects of alpha- and beta-receptors blocking drugs thereonThe Role of Renin in the Exaggerated Natriuresis of HypertensionCortisol responses to diazoxide in man and their possible relationship to effective blood volumeDas Verhalten der Plasmareninkonzentration nach akuter Natriurese und nach Orthostase bei Gesunden und HypertonikernAbnormal Responsiveness of the Renin Aldosterone System to Acute Stimulation in Patients with Essential HypertensionGORDON H. WILLIAMS, M.D., LESLIE I. ROSE, M.D., ROBERT G. DLUHY, M.D., DONALD MCCAUGHN, M.D., PAUL I. JAGGER, M.D., ROGER B. HICKLER, M.D., DAVID P. LAULER, M.D.Lead IntoxicationFunctional Correlates of Plasma Renin Activity in Hypertensive PatientsThe Relationship of Blood Pressure to Hospitalization, Dietary Sodium and Serum Renin in Essential HypertensionSuppressed Plasma Renin Activity in Essential Hypertension Roles of Plasma Volume, Blood Pressure, and Sympathetic Nervous SystemAUREA JOSE, M.D., J. RICHARD CROUT, M.D., F.A.C.P., NORMAN M. KAPLAN, M.D., F.A.C.P.Effect of Methyldopa on Plasma Renin Activity in ManHochdruck und Aldosteronismus bei solitären Adenomen und bei nodulärer Hyperplasie der NebennierenrindeSalivary Sodium-Potassium Ratio and Plasma Renin Activity in HypertensionALDOSTERONISM AND SPIRONOLACTONEJAMES G. HILTON, M.D.Primary Aldosteronism: Diagnosis and TreatmentTHE POSTURAL PLASMA RENIN ACTIVITY RESPONSE IN ESSENTIAL HYPERTENSION AND PRIMARY HYPERALDOSTERONISMLaboratory Aids in the Diagnosis of Endocrine DisordersRenin Release in Patients with Benign Essential HypertensionPLASMA ELECTROLYTES, RENIN, AND ALDOSTERONE IN THE DIAGNOSIS OF PRIMARY HYPERALDOSTERONISMIncidence of Suppressed Renin Activity and of Normokalemic Primary Aldosteronism in Hypertensive Negro PatientsExperimentelle Grundlagen zur Pathophysiologie des Renin-Angiotensin-SystemsDie Reninkonzentration im Plasma von Normalpersonen, Hypertonikern und Patienten mit Nephrotischem Syndrom 1 October 1967Volume 67, Issue 4Page: 791-799KeywordsBlood plasmaDietPlasma renin activityPostural controlSodium ePublished: 1 December 2008 Issue Published: 1 October 1967 PDF downloadLoading ...