tbuckley/cabot-search huggingface dataset:
STRICTURES OF THE FEMALE URETHRA.WITH REPORT OF CASES.
Authors: H. L. E. JOHNSON
Journal: JAMA (1904)

Strictures of the female urethra are narrowings of the intima of the canal of a greater or less degree, which impede or prevent the passage of the urine by the natural course from the bladder. They are congenital or acquired, single or multiple, and may be classified as stenosis or obstructive, atresia or retentive, atresia, non-retentive, when the urethra becomes occluded from disuse associated with vesicovaginal fistula and atresia with urine discharged through the umbilicus via a patulous urachus. Various modifications of these varieties are found associated with malformation of the bladder. Congenital atresiae are usually located at the neck of the bladder, or in the upper third of the urethra, but obliteration of the entire canal, or its absence, has been noted. Acquired cases, if traumatic, are situated at or near the site of the injury, while, if non-traumatic, they are found usually in the middle third of the
Rheumatoid Arthritis: discussions in patient management
Authors: M. Webley
Journal: Annals of the Rheumatic Diseases (1982)

This soft-backed section of Home Management is remarkably good value for £3-00.The layout remains the same as in previous editions, and both the pictures and the text are clear and well laid out.The only illustration I found difficult was that of international textile care labelling, which was so small that those with poor eyesight would have difficulty in reading it.This series of booklets should be in every rheumatology department.Physicians would not be wasting their time if they read the general introduction to each section when looking up a particular problem.The series is a mine of practical and useful information.
Combined disruption of both the MEK/ERK and the IL-6R/STAT3 pathways is required to induce apoptosis of multiple myeloma cells in the presence of bone marrow stromal cells
Authors: Manik Chatterjee, Thorsten Stühmer, Pia Herrmann, Kurt Bommert, Bernd Dörken, Ralf C. Bargou
Journal: Blood (2004)
Cancer/testis antigens are novel targets of immunotherapy for adult T-cell leukemia/lymphoma
Authors: Hiroyoshi Nishikawa, Yuka Maeda, Takashi Ishida, Sacha Gnjatic, Eiichi Sato, Fumiko Mori, Daisuke Sugiyama, Asahi Ito, Yasuo Fukumori, Atae Utsunomiya, Hiroshi Inagaki, Lloyd J. Old, Ryuzo Ueda, Shimon Sakaguchi
Journal: Blood (2012)
Hemostatic effects of low-dose protamine following cardiopulmonary bypass
Authors: Tetsuya Miyashita, Toshito Nakajima, Yukio Hayashi, Masakazu Kuro
Journal: American Journal of Hematology (2000)

Twenty-eight patients undergoing cardiac surgery were prospectively studied and were assigned to two groups. The patients received 0.8- (Group L) or 2.0-fold (Group H) dose of protamine for the neutralization after cardiopulmonary bypass (CPB) which was determined by Hepcon HMS® assay system in which the reagent chamber containing the concentration of protamine that completely neutralized the heparin had the shortest clotting time. Mean dose of protamine was 1.60 ± 0.50 mg kg−1 in Group L, and 3.56 ± 1.48 mg kg−1, respectively. Activated clotting times (ACT) were comparable between the two groups through this study period. In Group H, platelet counts significantly decreased to 69% of that before protamine administration, and plasma platelet factor 4 level significantly increased to approximate 2-fold of that before protamine administration just after protamine administration, respectively. However, these phenomena were not observed in Group L. In addition, these hemostatic changes occurred transiently just after protamine administration. We conclude that the low-dose protamine may prevent transient platelet depletion following CPB. Low-dose protamine can neutralize anticoagulation effect of heparin sufficiently and may mitigate protamine-induced platelet dysfunction. Am. J. Hematol. 64:112–115, 2000. © 2000 Wiley-Liss, Inc.
Photostimulation of Whole‐Cell Conductance in Primary Rat Neocortical Astrocytes Mediated by Organic Semiconducting Thin Films
Authors: Valentina Benfenati, Nicola Martino, Maria Rosa Antognazza, Assunta Pistone, Stefano Toffanin, Stefano Ferroni, Guglielmo Lanzani, Michele Muccini
Journal: Advanced Healthcare Materials (2013)

Astroglial ion channels are fundamental molecular targets in the study of brain physiology and pathophysiology. Novel tools and devices intended for stimulation and control of astrocytes ion channel activity are therefore highly desirable. The study of the interactions between astrocytes and biomaterials is also essential to control and minimize reactive astrogliosis, in view of the development of implantable functional devices. Here, the growth of rat primary neocortical astrocytes on the top of a light sensitive, organic polymer film is reported; by means of patch‐clamp analyses, the effect of the visible light stimulation on membrane conductance is then determined. Photoexcitation of the active material causes a significant depolarization of the astroglial resting membrane potential: the effect is associated to an increase in whole‐cell conductance at negative potentials. The magnitude of the evoked inward current density is proportional to the illumination intensity. Biophysical and pharmacological characterization suggests that the ion channel mediating the photo‐transduction mechanism is a chloride channel, the ClC‐2 channel. These results open interesting perspectives for the selective manipulation of astrocyte bioelectrical activity by non‐invasive, label‐free, organic‐based, photostimulation approaches.
Dengue in Travelers
Authors: Annelies Wilder-Smith, Eli Schwartz
Journal: New England Journal of Medicine (2005)

Dengue infection may be the most common infection other than malaria among travelers to tropical areas. This flavivirus infection is transmitted by mosquitoes. Although it often is asymptomatic, dengue infection can lead to leukopenia, thrombocytopenia, and even hemorrhagic complications and shock. This review summarizes the current approaches to establishing the diagnosis, managing the complications, and preventing this potentially dangerous infection.
TACH-MAN: Tachyarrhythmia Management
Authors: Ross J. Simpson
Journal: JAMA (1986)

TACH-MAN is an interactive program that simulates medical emergencies in a hypothetical patient suffering from a variety of common tachycardias, including ventricular tachycardia complicating myocardial infarction or drug treatment, supraventricular tachycardia, atrial fibrillation, atrial flutter, idioventricular rhythm, and rate-dependent bundle-branch block. If treatment is appropriate, the patient is cured; if improper, the player suffers a funeral dirge and tombstone exhibition. The intended audience consists of physicians, coronary care nurses, and rescue squad and other medical professionals caring for patients with tachycardia. One begins by selecting either a random or a specific scenario played on either of two levels: an introductory level that emphasizes the fundamentals of arrhythmia recognition and management, and an advanced level that stresses the fine points of management and the importance of speed in decision making. The program begins with a display of an electrocardiogram, the digital heart rate, respiratory rate, and blood pressure. The electrocardiogram and
Effects of human recombinant interleukin-1 on electrical properties of guinea pig ventricular cells
Authors: Y.-h. Li, G. J Rozanski
Journal: Cardiovascular Research (1993)

Journal Article Effects of human recombinant interleukin-1 on electrical properties of guinea pig ventricular cells Get access Yun-hua Li, Yun-hua Li University of Nebraska College of Medicine, 600 South 42nd Street, Omaha, NE 68189-4575, USA – Department of Internal Medicine (Cardiology): Y Li; Department of Physiology and Biophysics: G J Rozanski. Correspondence to Dr Rozanski. Search for other works by this author on: Oxford Academic PubMed Google Scholar George J Rozanski George J Rozanski University of Nebraska College of Medicine, 600 South 42nd Street, Omaha, NE 68189-4575, USA – Department of Internal Medicine (Cardiology): Y Li; Department of Physiology and Biophysics: G J Rozanski. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 27, Issue 3, March 1993, Pages 525–530, https://doi.org/10.1093/cvr/27.3.525 Published: 01 March 1993 Article history Received: 05 May 1992 Accepted: 09 September 1992 Published: 01 March 1993
A Japanese Subgroup Analysis of the Lapatinib for Gastric Cancer (TYTAN) Study
Authors: T. Satoh, T. Doi, A. Tsuji, Y. Omuro, H. Miwa, T. Nishina, H. Fujii, A. Mukaiyama, M. Kobayashi, A. Ohtsu, N. Mizunuma
Journal: Annals of Oncology (2013)
Stethoscopes and Infection
Authors: David Rimland
Journal: JAMA (1982)

<h3>To the Editor.—</h3> We are presently experiencing a hospital-wide outbreak of infections from methicillin- and tobramycin-resistant<i>Staphylococcus aureus</i>.<sup>1</sup>Despite intensive epidemiologic surveillance and selective culturing, the exact modes of transmission of the epidemic strain remain unclear. Previous studies<sup>2-4</sup>have shown a surprisingly high prevalence of pathogenic organisms cultured from ward stethoscopes. Simple wiping of the bell and diaphragm pieces with standard solutions markedly reduced the rate of colonization. To determine the possible role of stethoscopes in the outbreak of methicillin- and tobramycin-resistant<i>S aureus</i>infections, a sample of stethoscopes used by ward nurses, intensive care unit and coronary care unit nurses, physician associates, respiratory therapists, interns, residents, and faculty members was cultured in the following manner: The bell and diaphragm pieces of each stethoscope were pressed directly onto the selective culture medium ([Trypticase] soy agar with tobramycin, 20 μg/mL) and incubated in 5% carbon dioxide at 35 °C
Pediatric Device Information
Authors: Bridget M. Kuehn
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Evaluation of Left Atrial Functions and the Electromechanical Delay Time by Echocardiography in Patients with prediabetes
Authors: Naile Eris Güdül, Turgut Karabağ, Muhammet Rasit Sayin, Ibrahim Akpinar, Nesimi Yavuz, Mustafa Aydin
Journal: Journal of the American College of Cardiology (2013)
Eruptive and Tubero-eruptive Xanthomas of the Skin Arising on Sites of Prior Injury
Authors: Ghislaine Roederer
Journal: JAMA (1988)

Eruptive and tubero-eruptive xanthomas arising at the site of previous minor skin injury are described in two patients with type IV and type III hyperlipidemia, respectively. In one case, the lesions appeared following a cat scratch, while in the second, massive bee stinging preceded the appearance of a constellation of xanthomas. (<i>JAMA</i>1988;260:1282-1283)
Difficulty and Dependence: Two Components of the Disability Continuum among Community-Living Older Persons
Authors: Thomas M. Gill
Journal: Annals of Internal Medicine (1998)

Background: Although most epidemiologic studies have defined disability in basic activities of daily living (BADLs) as dependence, some investigators have argued that BADL disability should be defined as degree of difficulty. Objective: To determine whether the responses to questions about difficulty and dependence provide complementary information that together can depict the continuum of disability more fully than the response to either question alone. Setting: General community. Participants: 1065 persons 72 years of age and older. Measurements: On the basis of self-reported information collected at baseline, participants were categorized into three BADL groups: independent without difficulty, independent with difficulty, and dependent. Additional baseline information was collected on several measures of higher-level function and physical performance. Follow-up information was collected on regular home care visits and BADL function at 1 and 3 years and on hospitalizations, admissions to skilled-nursing facilities, and deaths over a 4-year period. Results: In a cross-sectional analysis, the proportion of participants with poor higher-level function and physical performance increased substantially across the three BADL groups. In a longitudinal analysis, the rates of hospitalization and regular home care visits for the independent without difficulty group, the independent with difficulty group, and the dependent group were 46%, 57%, and 72% (P < 0.001) and 17%, 30%, and 49% (P < 0.001), respectively; survival curves for admission to a skilled-nursing facility and death differed significantly for each pair-wise comparison. Among persons who were BADL independent, those with difficulty were significantly more likely to develop BADL dependence over a 3-year period than those without difficulty (31% compared with 18%; P < 0.001). Conclusions: In the assessment of BADL function in older persons, questions about difficulty and dependence provide complementary information that together can depict the continuum of disability more fully than either question alone.
Action of erythropoietin in vitro on rabbit reticulocyte membrane Ca2+-ATPase activity.
Authors: W D Lawrence, P J Davis, S D Blas
Journal: Journal of Clinical Investigation (1987)

The mechanism of action of erythropoietin is thought to require specific interaction with the target cell surface and involve alteration of cellular calcium metabolism. Using the rabbit reticulocyte membrane as a model of the immature red cell membrane, we investigated the effects of human recombinant erythropoietin on membrane Ca2+-ATPase (calcium pump) activity in vitro. Erythropoietin in a concentration range of 0.025 to 3.0 U/ml progressively decreased membrane Ca2+-ATPase activity by up to 64% (P less than 0.01). These concentrations have been shown by others to stimulate in vitro erythroid growth. The action of erythropoietin on reticulocyte Ca2+-ATPase required an incubation time of 1 h before enzyme assay for maximum effect and was neutralized by antierythropoietin antiserum. Other nonhemopoietic growth factors (epidermal growth factor, insulin) had no effect in this assay. Ca2+-ATPase activity of membranes prepared from rabbit mature red blood cells was not inhibited by erythropoietin. The novel effect of erythropoietin on reticulocyte membrane Ca2+-ATPase activity is a mechanism by which erythropoietin can influence cellular Ca2+ metabolism.
Increased Probability of Remaining in Remission from Panic Disorder with Agoraphobia after Drug Treatment in Patients Who Received Concurrent Cognitive-Behavioural Therapy: A Follow-Up Study
Authors: Massimo Biondi, Angelo Picardi
Journal: Psychotherapy and Psychosomatics (2002)

Many short-term trials suggested that the combination of psychotherapy with medication might be more effective than either treatment alone. However, only few studies examined the long-term effectiveness of this combination.A private practice sample of consecutive patients with DSM-III-R panic disorder with agoraphobia who achieved remission after drug treatment with or without concurrent cognitive-behavioural psychotherapy were followed up. Patients were assessed before treatment, after treatment and at each follow-up contact with the Marks-Sheehan Phobia Scale, the Hamilton Anxiety Rating Scale, and the Hamilton Depression Rating Scale. Kaplan-Meier survival analysis was performed on the time to panic disorder relapse. Cox regression analysis was used to control for the possible confounding effect of factors other than treatment.Of patients who received medication alone (n = 32), 25 (78.1%) relapsed, prevalently (65.6%) during the first year. The estimated mean survival time was 12 months (95% CI 7-17). Of patients who received integrated treatment (n = 21), only 3 (14.3%) relapsed. The estimated mean survival time was 65 months (95% CI 44-86). Treatment was the only variable associated with the occurrence of relapse, with a hazard ratio of 12.6 (95% CI 2.5-63.3) for patients who received only medication.Some methodological limitations, such as treatment allocation by preference, suggest caution in the interpretation of our results. However, the long-term therapeutic advantage of integrated treatment over medication alone was large and independent from known prognostic factors. The long-term effectiveness of integrated treatment should be tested with a randomised controlled trial.
HIV Prevention: Community Planning Groups
Authors: David R. Holtgrave
Journal: JAMA (1995)

<h3>To the Editor.</h3> —Mr Stryker and colleagues<sup>1</sup>summarized several barriers to effective human immunodeficiency virus (HIV) prevention programs, but did not make any mention of the revolutionary changes that have occurred in the past 2 years in the way HIV prevention programs are planned in the United States. Sixty-five health department grantees (all states, several cities, the District of Columbia, and the US territories) who receive HIV prevention funding from the Centers for Disease Control and Prevention (CDC) are required to work in close partnership with community planning groups (CPGs) when prioritizing HIV prevention needs and interventions to meet those needs.<sup>2</sup>In total, these grantees received approximately $175 million in HIV prevention cooperative agreements in fiscal year 1994. Additionally, they received over $12 million in fiscal year 1994 resources to support HIV prevention community planning activities. Membership in a CPG should be inclusive and representative of the local
338 Comparative efficacy and safety of loratadine. hydroxyzine, and placebo in chronic idiopathic urticaria (CIU)
Authors: E MONROE, R FOX, J KALIVAS, I KATZ, D BERNSTEIN, R HONSINGER, S GRABIEC, P GARVIN, F CUSS, B LUTSKY
Journal: Journal of Allergy and Clinical Immunology (1991)
Relationship Between Leucocyte and Plasma Ascorbic Acid Concentrations
Authors: H. S. Loh, C. W. M. Wilson
Journal: BMJ (1971)

Leucocyte and plasma ascorbic acid values were measured in healthy students, adult factory employees, and old people not receiving supplementary vitamin C and in healthy old people receiving 500 mg of vitamin C daily. Significant positive correlations between leucocyte and plasma ascorbic acid were found in all the groups. The regression lines differed significantly between one another within the sexes, but the pooled lines for each sex did not differ significantly in the unsupplemented groups. The relationship between plasma and leucocyte ascorbic acid values in the supplemented group differed significantly from that in the pooled unsupplemented groups.There was a limited range of variation in leucocyte ascorbic acid values compared with the range in plasma values in the supplemented group, whereas there was a wider range of variation in the leucocyte values in the unsupplemented groups. Leucocytes can therefore achieve a saturation level of ascorbic acid. Measurement of leucocyte ascorbic acid concentrations alone does not provide a reliable guide for the estimation of tissue status of ascorbic acid in normal individuals. Leucocyte concentrations provide a measure of the availability of ascorbic acid for storage, and plasma levels give an indication of its metabolic turnover rate. When these values are related the regression lines provide information about the storage and metabolism of ascorbic acid in normal individuals.
Disorders of Voluntary Muscle
Authors: Irwin M. Siegel
Journal: JAMA (1982)

Walton's<i>Disorders of Voluntary Muscle</i>, like<i>Harrison's Principles of Internal Medicine</i>or the<i>Davis-Christopher Textbook of Surgery</i>, has become a classic in its field. This fourth edition (the first was published in 1964, the third six years ago) is a welcome response to the almost exponential growth of the investigation of neuromuscular disease over the past five years and, like all of Professor Walton's publications, reflects a high standard of excellence, both in conception and execution. The present volume has undergone numerous alterations and modifications. Its format is totally different from the previous edition. This "has allowed extensive revision and restructuring of many of the chapters, with complete rewriting of others." Also new is a short section on the involvement of human muscle by parasites, as well as a chapter on drug-induced neuromuscular disorders. Like its first edition, this book is "aimed primarily at the clinician, whether he be a
The Social Missions of Academic Health Centers
Authors: David Blumenthal, Eric G. Campbell, Joel S. Weissman
Journal: New England Journal of Medicine (1997)

Academic health centers have long enjoyed positions of power and prestige in the health care system. However, the restructuring of health care — exemplified by the spread of competition and managed care — threatens the intricate system of financial and clinical relations on which these institutions depend.1,2 Although these challenges have led to considerable discussion about the appropriate role of academic health centers and how they should be organized and financed, a fundamental question is generally overlooked: Why are academic health centers worth our concern and protection? More specifically, is there any reason they should not be left to . . .
Business travel and sexually transmitted diseases.
Authors: L Elliott, L Cowan, L Gruer, A Hardie
Journal: BMJ (1993)

If relevant to clinical practice these in vitro observations suggest that pseudoallergic drug reactions may be regulated not by pharmacological specificity but by relatively non-specific protein binding properties.The displacement properties of acidic or basic protein binding drugs and effects of released vasoactive mediators are probably additive.The adverse reactions experienced by the patient reported on may therefore be attributable to the drug regimen and not solely to dexamethasone.