tbuckley/cabot-search huggingface dataset:
Acceptance and Commitment Therapy: A Meta-Analytic Review
Authors: Mark B. Powers, Maarten B. Zum Vörde Sive Vörding, Paul M.G. Emmelkamp
Journal: Psychotherapy and Psychosomatics (2009)

There are now a substantial number of controlled trials investigating the efficacy of acceptance and commitment therapy (ACT). This meta-analysis combined multiple well-controlled studies to help clarify the overall impact of ACT relative to waiting lists, psychological placebos, treatment as usual, and established therapies.A comprehensive literature search produced 18 randomized controlled trials (n = 917) that were included in the final analyses. Effect size was computed with Hedges's g which can be interpreted with Cohen's convention of small (0.2), medium (0.5), and large (0.8) effects.There was a clear overall advantage of ACT compared to control conditions (effect size = 0.42). The average ACT-treated participant was more improved than 66% of the participants in the control conditions. Analyzed separately ACT was superior to waiting lists and psychological placebos (effect size = 0.68) and treatment as usual (effect size = 0.42). However, ACT was not significantly more effective than established treatments (effect size = 0.18, p = 0.13). Also, ACT was not superior to control conditions for the distress problems (anxiety/depression: effect size = 0.03, p = 0.84).The results reveal that ACT is more effective than control conditions for several problem domains, but there is no evidence yet that ACT is more effective than established treatments.
PASSIVE TRANSFER OF TUBERCULIN SENSITIVITY BY TRITIATED THYMIDINE-LABELED LYMPHOID CELLS
Authors: John S. Najarian, Joseph D. Feldman
Journal: The Journal of Experimental Medicine (1961)

Passive transfer of tritiated thymidine-labeled BCG sensitized lymphoid cells into homologous guinea pigs resulted in positive tuberculin skin reactions 24 hours after testing with PPD. Labeled cells were found specifically attracted to these sites. Labeled non-sensitized lymphoid cells did not appear at PPD injection sites, nor did labeled sensitized cells accumulate in non-specific inflammatory lesions. The specifically reacting tritiated cells were small, medium, and large lymphocytes and stem or immature cells of the lymphoid series. In the homologous system employed, positive skin tests were either minimal or absent 3 days after transfusion of activated cells. The injected labeled sensitized cells were rapidly cleared from the circulating blood and lodged in the lungs, spleen, and lymph nodes. Upon application of specific antigen they reappeared at the skin test site at 6 hours and then increased in number for the next 18 hours.
SPINAL INJURIES IN INFANTS.
Authors: JAMES PORTER FISKE
Journal: JAMA (1896)

unimportant part in the complications, or, I might say, in the development of the affection, and on that account may be easily overlooked.It is usually tem- porary, as desquamative nephritis is in scarlatina.Yet that it may and does occur to a greater or less extent, this is quite sufficient, as said, to emphasize the suggestion and point attention to it, that we may in the future properly consider its probable immedi- ate or remote tendencies and results.Glycosuria is not properly a complication any more than endoor peri-carditis are complications in inflam- matory or articular rheumatism, or, as now taught, rheumatic fever.It is a part of the disease, as nephritis in scarlet fever, and pulmonary extension in per- tussis and measles, and originates from the same cause, so that in treating a case of whooping cough, it is well to have in mind all the symptomatic mani- festations which may be developed in its course-those that are so far well known and appreciated, as well as the possibilities of some others, not perhaps in the category of direct symptoms, but which may be elicited by careful inquiry pursued in the right direction.
The integrated value of serum procollagen III peptide over time predicts hepatic hydroxyproline content and stainable collagen in a model of dietary cirrhosis in the rat
Authors: Mary J. Ruwart, Karen F. Wilkinson, Bob D. Rush, Thomas J. Vidmar, Kenneth M. Peters, Keith S. Henley, Henry D. Appelman, Kiyoung Y. Kim, Detlef Schuppan, Eckert G. Hahn
Journal: Hepatology (1989)

To determine whether a serum parameter of collagen metabolism, serum procollagen type III peptide, correlated with hepatic collagen in a model of diet–induced fibrosis, rats were fed a control or cirrhogenic diet for 6 months and treated with either subcutaneous vehicle or the hepatoprotective prostaglandin 16,16–dimethyl prostaglandin E2 (100 μg per kg) twice daily. Pair–fed rats from each group were killed after 2, 4 or 6 months. The value of serum procollagen type III peptide to body weight integrated over time (K t ) correlated linearly with hepatic hydroxyproline content (r = 0.97) at killing time t. Good correlations were also seen between K t and histopathological assessment of aniline blue–stainable collagen (r = 0.93) and between the histopathology and hydroxyproline content (r = 0.97). Rats receiving 16,16–dimethyl prostaglandin E 2 had lower values of all three parameters compared to rats receiving vehicle, confirming the previously demonstrated hepatoprotective effect of 16,16–dimethyl prostaglandin E 2 . The excellent correlation between K t and the two other traditional parameters of hepatic collagen suggest that sequential measurements of serum procollagen type III peptide can be used to predict alterations in liver collagen deposition in rats.
THE PERSISTENCE IN MICE OF CERTAIN FOREIGN PROTEINS AND AZOPROTEIN TRACER-ANTIGENS DERIVED FROM THEM
Authors: Philip D. McMaster, Heinz Kruse
Journal: The Journal of Experimental Medicine (1951)

Methods have been devised whereby the persistence of foreign antigens in mice can be detected. A highly diffusible, blue azo dye, echt-säure-blau was coupled to bovine gamma-globulin and human serum albumin and injected into the animals. In this way deep blue tracer antigens were obtained. These were promptly stored in cells widely distributed throughout the body, especially in the reticulo-endothelial elements of the liver, spleen and mesenteric lymph nodes. The dye as such was not stored but rapidly excreted. A blue coloration in the organs just mentioned was still perceptible after 85 to 120 days in the case of the azoglobulin and 36 to 44 days in that of the azoalbumin. To determine whether these substances had actually persisted, as well as to learn how long uncoupled globulin and albumin remained after injection, recourse was had to the phenomenon of reversed passive anaphylaxis, which was found to be characterized by extraordinary changes in the vessels of the ears (EVR) in the mouse, plainly visible under the microscope when called forth by an antiserum specific for the antigen to which the animal had been sensitized. So sensitive is the vascular response that as little as 0.5 to 0.1 microg. of protein as antigen, previously injected into the peritoneal cavity of a 30 gm. mouse, can be detected a few days later by an intravenous injection of antiserum. By means of the EVR the globulin antigen has been detected in the blood and livers of injected mice for as long as 56 and 101 days, respectively; the albumin and azoalbumin for only 21 and 36 days. In the mesenteric lymph nodes of injected mice the albumin and azoalbumin antigens were found after 42 and 44 days, respectively. The hepatic tissue and that of the mesenteric lymph nodes of mice injected with azoalbumin, containing in consequence stored blue material, when transferred to recipient mice yielded positive tests for antigen (EVR) as long as blue color could be perceived in these tissues with the unaided eye, or at low magnification. After the color had disappeared from the tissues the transfer tests were found to be negative. This fact speaks for the antigenicity of the colored material. In summary it is plain that certain antigenic proteins, after introduction into the blood stream of mice, are stored in certain tissues and that they may persist there for weeks or even months, far longer than has generally been supposed. This persistence of antigen within the body, especially after detectable amounts of antigen have apparently disappeared from the blood, provides a reason for prolonged antibody formation, a phenomenon for which no adequate explanation has hereto been offered.
Allergic contact dermatitis from cedar wood (Thuja plicata)
Authors: E. BLEUMINK, J. C. MITCHELL, J. P. NATER
Journal: British Journal of Dermatology (1973)

Journal Article Allergic contact dermatitis from cedar wood (Thuja plicata) Get access E. BLEUMINK, E. BLEUMINK Department of Dermatology, State University, Oostersingel 59, Groningen, The Netherlands, and Department of Medicine, Division of Dermatology, The University of British Columbia, Vancouver, Canada Search for other works by this author on: Oxford Academic Google Scholar J. C. MITCHELL, J. C. MITCHELL Department of Dermatology, State University, Oostersingel 59, Groningen, The Netherlands, and Department of Medicine, Division of Dermatology, The University of British Columbia, Vancouver, Canada Search for other works by this author on: Oxford Academic Google Scholar J. P. NATER J. P. NATER Department of Dermatology, State University, Oostersingel 59, Groningen, The Netherlands, and Department of Medicine, Division of Dermatology, The University of British Columbia, Vancouver, Canada Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 88, Issue 5, 1 May 1973, Pages 499–504, https://doi.org/10.1111/j.1365-2133.1973.tb15458.x Published: 01 May 1973 Article history Accepted: 26 October 1972 Published: 01 May 1973
Effects of Stimulation Frequency on Myocardial Extensibility
Authors: ERIC O. FEIGL
Journal: Circulation Research (1967)

Whether a change in myocardial contractility is accompanied by a change in diastolic extensibility was studied by altering stimulation frequency, including paired stimulation, as the inotropic intervention. Isometric and isotonic contractions of isolated cat papillary muscles were examined. Apparent changes in diastolic extensibility were observed with paired stimulation in isometric preparations. Rapid changes were seen only in muscles that had spontaneous aftercontractions between driven beats. These changes were believed not to reflect true extensibility changes but rather a change in timing between the relaxation of a beat driven by a paired stimulus and the onset of an aftercontraction. In continuous isotonic (not afterloaded) preparations, end-diastolic length depended on beat frequency. The muscle crept to a longer length when diastole was prolonged by decreasing the heart rate. In isotonic experiments without aftercontractions myocardial extensibility remained unchanged during paired electrical stimulation and changes in beat frequency.
Blue Light for Skin Infections
Authors: Tracy Hampton
Journal: JAMA (2013)

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Lab Reports | March 6, 2013
Blue Light for Skin Infections
Tracy Hampton, PhD
JAMA. 2013;309(9):865. doi:10.1001/jama.2013.1846.
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Article

Blue light may be an effective, nontoxic approach for treating skin and soft tissue infections, report researchers at Massachusetts General Hospital and Harvard Medical School, in Boston
Trichophyton mentagrophytes kerion in a woman
Authors: N. Aste, M. Pau, P. Biggio
Journal: British Journal of Dermatology (1996)

Journal Article Trichophyton mentagrophytes kerion in a woman Get access N. Aste, N. Aste Clinic of Dermatology. University of Cagliari. Cagliari, Italy Search for other works by this author on: Oxford Academic Google Scholar M. Pau, M. Pau Clinic of Dermatology. University of Cagliari. Cagliari, Italy Search for other works by this author on: Oxford Academic Google Scholar P. Biggio P. Biggio Clinic of Dermatology. University of Cagliari. Cagliari, Italy Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 135, Issue 6, 1 December 1996, Pages 1010–1011, https://doi.org/10.1046/j.1365-2133.1996.d01-1116.x Published: 01 December 1996
Risk in Acquiring Toxoplasma Antibodies
Authors: George A. Lamb
Journal: JAMA (1968)

<i>Toxoplasma</i>dye-test antibodies were acquired by three of 189 members of a population of 37 "normal" families during a four-year period. The three members were aged 2, 3, and 17 years, respectively. Initially, 5% of those &lt;20 years had such antibodies in contrast with 38% of those ≥20 years of age. Antibodies were equally frequent in males and females. The three infections occurred during 7,176 susceptible person-months, or one per 2,392 person-months of overall observation and one per 1,831 person-months for those &lt;20 years.
A Triad for the Diagnosis of Pulmonary Embolism and Infarction
Authors: Warren E. C. Wacker
Journal: JAMA (1961)

A new method for the diagnosis of pulmonary embolism and infarction is provided by serial measurements of the serum LDH (lactic dehydrogenase) activity, SGOT (serum glutamic oxalacetic transaminase) activity, and serum bilirubin concentration. The serum LDH activity was consistently elevated and the SGOT activity was consistently normal in a series of 17 patients with pulmonary embolism or infarction. In 12 of these 17 patients the serum bilirubin was significantly increased. Using this triad permits the recognition of pulmonary embolism and infarction and makes it possible to differentiate them from acute myocardial infarction and pneumonia, the 2 diseases with which they are most often confused.
Cloning, identification, and epitope-mapping two black walnut (Juglans niger) allergens
Authors: M. Ling, J. Ye, K. Beyer, G. Cockrell, G.A. Bannon, J.S. Stanley, R.M. Helm, H.A. Sampson, A.W. Burks
Journal: Journal of Allergy and Clinical Immunology (2003)
Serum Lithium Levels and Long-term Diuretic Use
Authors: James W. Jefferson
Journal: JAMA (1979)

In normal volunteers whose conditions were stablized with lithium carbonate, there were no significant changes in serum lithium levels during a two-week period while they received 40 mg/day of furosemide. During another two-week period, a 50 mg/day dosage of hydrochlorothiazide did cause a significant rise in serum lithium levels. These observations suggest that a substantial amount of lithium and a loop diuretic may not require modification of the lithium dosage.
The Mammalian Crx Genes Are Highly Divergent Representatives of the Otx5 Gene Family, a Gnathostome Orthology Class of Orthodenticle-Related Homeogenes Involved in the Differentiation of Retinal Photoreceptors and Circadian Entrainment
Authors: Jean-Louis Plouhinec, Tatjana Sauka-Spengler, Agnès Germot, Chantal Le Mentec, Thérèse Cabana, Gavan Harrison, Claude Pieau, Jean-Yves Sire, Géraldine Véron, Sylvie Mazan
Journal: Molecular Biology and Evolution (2003)

The mammalian Crx genes are highly divergent orthodenticle (otd)-related homeogenes that play important roles in the differentiation of retinal photoreceptors and the circadian entrainment. However, their evolutionary origin and orthological relationships with other otd-related genes remain unclear. An orthology relationship of these genes with the highly conserved Otx5 genes identified in fish and amphibians, and also expressed in the eye and epiphysis, has been proposed previously but remains controversial. To test this hypothesis, we have identified Crx genes in a wide range of mammals, including three marsupials, and Otx5-related genes in a lizard, a turtle, and two archosaurs (crocodile and chick), as well as in the pufferfish. Phylogenetic analyses of the coding sequences show that the mammalian Crx genes are orthologous to the Otx5-related genes isolated in other gnathostomes. They also indicate that a duplication event has taken place in actinopterygians, after the splitting of the Cladistia, and that a relaxation of the structural constraints acting on the gene coding region has occurred early in the mammalian lineage. This process may be linked not only to the loss of ancestral Otx5/Crx functions during gastrulation or in the retinal pigmented epithelium, but also to the evolution of photic entrainment mechanisms in mammals.
Intranasal Exposure to<i>Stachybotrys chartarum</i>Enhances Airway Inflammation in Allergic Mice
Authors: Marina S. Leino, Harri T. Alenius, Nanna Fyhrquist-Vanni, Henrik J. Wolff, Kari E. Reijula, Eeva-Liisa Hintikka, Mirja S. Salkinoja-Salonen, Tari Haahtela, Mika J. Mäkelä
Journal: American Journal of Respiratory and Critical Care Medicine (2005)

Exposure to building dampness, often associated with growth of microbes such as Stachybotrys chartarum, has been linked to respiratory symptoms. We have shown previously in a murine model that exposure to S. chartarum can induce lung inflammation characterized by infiltration of neutrophils and lymphocytes; this process is regulated by proinflammatory cytokines and leucocyte-attracting chemokines.Because an atopic predisposition may influence the response to microbes, we examined the effects of S. chartarum on allergic mice in an experimental model. BALB/c mice were sensitized to ovalbumin by intraperitoneal injections and exposed for 3 wk to spores of S. chartarum.Numbers of eosinophils and neutrophils were drastically increased in bronchoalveolar fluid from these mice as compared with the ovalbumin-sensitized/challenged mice or those exposed to S. chartarum without ovalbumin sensitization. Histologic sections showed severe granulomatous inflammatory cell infiltrates in all compartments of the lung, including peribronchial, perivascular, and alveolar spaces. The mRNA levels of proinflammatory cytokines interleukin-1beta and tumor necrosis factor alpha and the chemokine CCL3/MIP-1alpha were also markedly increased in the lungs. Despite the enhancement of the pulmonary inflammatory reaction, exposure to S. chartarum spores significantly down-regulated airway hyperresponsiveness and showed a tendency to decrease levels of Th2 cytokines in the lung.Exposure to S. chartarum modulates the inflammatory reaction and airway hyperresponsiveness, depending on the allergic status of the exposed mice.
Pre-signing of forms found in 14 out of 249 abortion clinics in England
Authors: Z. Kmietowicz
Journal: BMJ (2012)

Fourteen abortion clinics in England have been told to stop pre-signing forms that authorise a termination after the health and social care watchdog inspected all 249 NHS and private providers.1 No evidence of poor outcomes was found at any of the clinics inspected by the Care Quality Commission.

Health secretary Andrew Lansley ordered the commission to inspect all abortion providers in England after it found in January that forms had been pre-signed by one doctor at a private clinic. This breaches the Abortion Act because, except in emergencies, two doctors must certify …
EU to ban use of unsubstantiated health claims for food products
Authors: R. Watson
Journal: BMJ (2003)

Food and drink manufacturers will have to prove scientifically the health and nutritional claims they make for their products under new legislation tabled by the European Commission last week.

The legislation would prevent labels that extol virtues attributed to many foods and food supplements we eat—such as being low in energy, fat free, or high in protein—unless the labels fully comply with clear standards.

Similarly, vague terms such as “preserves youth,” “improves your memory,” or “reduces your calorie intake,” which are used as marketing …
87 SINGLE USE OF ROMIPLOSTIM THROMBOPOIETIN ANALOGUE IN SEVERE THROMBOCYTOPENIA FOR OUTPATIENT PERCUTANEOUS LIVER BIOPSY IN PATIENTS WITH CHRONIC LIVER DISEASE-A RANDOMIZED DOUBLE BLINDED PROSPECTIVE TRIAL
Authors: P.P. Basu, T. Nair, S. Farhat, N. James Shah, M. Jafri, S. Foustin
Journal: Journal of Hepatology (2012)
Care of dying patients in hospital
Authors: E. Lewis
Journal: BMJ (1995)

and other details of the protocol.The effect of this adjustment was to reduce our estimated increase in mean dose-response ratio between 1982 and 1992.Until Booth and colleagues publish the details of their methods and their data, and until clinical data on the practical effects of differences between nebulisers are available, we suggest that our method of adjusting for methodological differences on the basis of our own epidemiological data was the most accurate adjustment that could be made.Using that adjustment, we found that the level of airway responsiveness had increased between 1982 and 1992 in both study regions.This finding, which supported our conclusions that the children studied in 1992 had a higher prevalence of airway hyperresponsiveness than the children studied in 1982, is consistent with other Australian studies that have reported a significant increase in the prevalence and severity of asthma.3
The Value of Time in Assessing the Effectiveness of Newborn Screening for Congenital Adrenal Hyperplasia
Authors: Beth A. Tarini
Journal: JAMA Pediatrics (2014)

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