Alcoholic Hepatitis and Corticosteroids
Authors: CARROLL M. LEEVY
Journal: Annals of Internal Medicine (1973)

Editorials1 November 1973Alcoholic Hepatitis and CorticosteroidsCARROLL M. LEEVY, M.D., ROWEN ZETTERMAN, M.D.CARROLL M. LEEVY, M.D.Search for more papers by this author, ROWEN ZETTERMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-79-5-739 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDuring the past decade, much progress has been made in understanding the pathobiology of alcoholic hepatitis. Prospective natural history studies indicate that 80% of patients with this lesion who continue to drink develop cirrhosis within 5 years (1); this is consistent with the finding that ethanol causes increased in-vitro incorporation of tritiated proline into collagen of biopsy specimens of alcoholic hepatitis (2). Alcoholic hepatitis occurs in only 10% to 30% of patients with a history of chronic alcoholism in which intake of alcoholic beverages is sufficient to interfere with work, social responsibilities, and proper food intake. This variation in susceptibility...References1. LEEVY C: Hard liquor and cirrhosis, in Alcoholic Cirrhosis and Other Toxic Hepatopathias; Symposium, September 29-October 1, 1969. Edited by ENGEL A, LARSSON T. Stockholm, Nordiska bokhandelns förlag, 1970, p. 283 Google Scholar2. CHENLEEVY TC: Collagen biosynthesis in hepatic fibrosis (abstract). Gastroenterology 64:178, 1973 Google Scholar3. MALLORY F: Cirrhosis of the liver. Five different types of lesions from which it may arise. Bull Johns Hopkins Hosp 22:69-75, 1911 Google Scholar4. REYNOLDSHIDEMURAMICHEL TRH: Portal hypertension without cirrhosis in alcoholic liver disease. Ann Intern Med 70:497-506, 1969 LinkGoogle Scholar5. 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Gastroenterology 63:820-833, 1972 CrossrefMedlineGoogle Scholar18. CAMPRAHAMLINKIRSHBAUM JER: Prednisone therapy of acute alcoholic hepatitis. Report of a controlled trial. Ann Intern Med 79:625-631, 1973 LinkGoogle Scholar19. HELMANTEMKONYE RMS: Alcoholic hepatitis. Natural history and evaluation of prednisolone therapy. Ann Intern Med 74:311-321, 1971 LinkGoogle Scholar20. PORTERSIMONPOPE HFC: Corticosteroid therapy in severe alcoholic hepatitis. A double-blind drug trial. N Engl J Med 284:1350-1355, 1971 CrossrefMedlineGoogle Scholar21. BLITZERMUTCHNICKJOSHI BMP: Adrenocorticosteriod therapy in alcoholic hepatitis: a prospective double-blind, randomized study (abstract). Gastroenterology 64:880, 1973 Google Scholar22. LEEVY C: Liver Regeneration in Man, Springfield, Illinois, Charles C Thomas, Publisher, 1973 Google Scholar23. . Effect of prednisone on the survival of patients with cirrhosis of the liver. Lancet 1:119-121, 1969 MedlineGoogle Scholar24. DAVIDSON C: Alcoholic hepatitis. N Engl J Med 284:1378 1971 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: CARROLL M. LEEVY, M.D.; ROWEN ZETTERMAN, M.D.Affiliations: Division of Hepatology and Nutrition Department of Medicine College of Medicine and Dentistry of New Jersey Newark, New Jersey PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDAlcoholic HepatitisAlcoholic Hepatitis Superimposed on Cirrhosis. Clinical Significance and Effect of Long-term Prednisone Treatment 1 November 1973Volume 79, Issue 5Page: 739-740KeywordsAlcoholicsAlcoholismBiopsyCirrhosisEatingEthanolHepatitisHepatitis ALesionsProspective studies ePublished: 1 December 2008 Issue Published: 1 November 1973 PDF downloadLoading ...