tbuckley/cabot-search huggingface dataset:
Oral prednisone in the treatment of acne agminata
Authors: Y. UESUGI, S. AIBA, M. USUBA, H. TAGAMI
Journal: British Journal of Dermatology (1996)

Acne agminata (lupus miliaris disseminatus faciei), once regarded as a tuberculide, is a facial granulomatous disease still seen in young adults in Japan, despite a decrease in the incidence of tuberculosis. Although most lesions regress within a few years, even without treatment, disfiguring scars remain on the face. We have evaluated the efficacy of low dose oral prednisone therapy because, in the past, there has been no satisfactory therapy for this condition. We have treated four patients with acne agminata with prednisone, at first 10 mg daily for 2 weeks, decreasing to 5 mg daily for 3 months. This modest dosage was found to give an excellent result in three patients and a poor result in one whose treatment was started at a much later stage of the disease than in the others. Acne agminata can be cured without scar formation when oral steroids are started in an early phase of the disease.
Increased portal venous resistance hinders portal pressure reduction during the administration of β-adrenergic blocking agents in a portal hypertensive model
Authors: Richard J. Kroeger, Roberto J. Groszmann
Journal: Hepatology (1985)

We have recently shown that maintenance of portal hypertension in rats is highly dependent on high portal blood flow. This study attempts to determine whether portal hypertension, induced in the rat by partial constriction of the portal vein, can be reduced by lowering portal blood flow with a beta blocking agent. Portal hypertensive rats treated with propranolol had a reduction in portal blood flow to 0.89 ± 0.13 ml · min−1 · gm−1 accompanied by reduction in portal pressure to 12.6 ± 1.00 mm Hg, disproportionately small because of a rise in portal-collateral vascular resistance to 12.52 ± 1.63 dyne · sec · cm−5 · gm · 105 accompanying the portal blood flow reduction. Similarly, portal hypertensive rats receiving β-blockade with H35–25, an experimental β-blocker, demonstrated a 49% reduction in portal blood flow accompanied by only a 14% reduction in portal pressure, also disproportionately low because of a complicating 77% rise in portal-collateral vascular resistance. Normal rats were then given saline infusion to achieve similar blood flow elevations to that of portal hypertensive animals. Within a similar portal blood flow range of 0.76 ± 0.14 to 1.31 ± 0.07 ml · min−1 · gm−1, Portal hypertensive animals exhibited a significantly higher portal pressure range (12.6 ± 1.0 to 15.4 ± 0.4 mm Hg) than normals (8.9 ± 0.4 to 9.5 ± 0.4 mm Hg) largely due to a significantly higher range of portal resistance offered to portal blood flow by the portal-collateral bed of portal hypertensive rats (9.39 ± 0.25 to 16.63 ± 1.45 dyne · sec · cm−5 · gm · 105) in comparison with the portal venous system of normal animals (5.47 ± 0.70 to 10.00 ± 0.43 dyne · sec · cm−5 · gm · 105). We conclude that, in a hyperdynamic model of portal hypertension, the increase in portal pressure appears to be the result of combined elevations in portal blood flow and the portal vascular resistance to that flow. β-Blockade completely corrects the portal blood flow factor, but will be unable to adequately reduce portal pressure until the additional element of elevated portal vascular resistance can also be reduced.
Indications for operation in suspected appendicitis and incidence of perforation
Authors: R Andersson, A Hugander, A Thulin, P O Nystrom, G Olaison
Journal: BMJ (1994)

To clarify poorly understood epidemiological features of appendicitis.Retrospective study of consecutive cases from a defined population and analysis of data from published studies.County of Jönköping, Sweden. 3029 patients who underwent operation in 1984-9 and 4717 patients from the county town who underwent operation in 1970-89, all for suspected appendicitis, plus 48,426 cases from six reported studies.Incidences specific for age and sex and temporal trends of perforating and non-perforating appendicitis and removal of a normal appendix. Associations between diagnostic accuracy, rate of perforation, and incidences of removal of a normal appendix and of perforating and non-perforating appendicitis.The incidence of appendicitis was 116/100,000 inhabitants. Appendicitis was more common in male patients. The incidence of perforating appendicitis was independent of age, stable over time, and uninfluenced by the rate of laparotomy, whereas the incidence of non-perforating appendicitis was age dependent, decreasing over time, and related to the diagnostic accuracy and rate of removal of a normal appendix.Perforating and non-perforating appendicitis seem to be separate entities, and appendicitis that resolves spontaneously is common. This may have important implications for managing suspected appendicitis.
LOCALIZATION OF FREE AND BOUND SECRETORY COMPONENT IN HUMAN INTESTINAL EPITHELIAL CELLS
Authors: Marshall E. Poger, Michael E. Lamm
Journal: The Journal of Experimental Medicine (1974)

Antibody reagents were made specific for each of the two forms of human SC, FSC and BSC, which is an integral part of the sIgA molecule. With the fluorescent antibody method the cytological and histological localization of FSC, BSC, and alpha-chains has been studied in various human mucous membranes. SC was present in columnar epithelial cells of the intestines and in the cells of serous acini of bronchial and salivary glands. In contrast, SC was not found in intestinal goblet cells or cells of mucous acini of bronchial and salivary glands. In the columnar epithelial cells of the small and large bowel, FSC was present most prominently in the Golgi zone, and much less prominently in the apical cytoplasm. On the other hand, BSC and alpha-chains were located only in the apical cytoplasm in an overlapping manner. The results favor a model in which sIgA is assembled inside epithelial cells from SC, which was synthesized in the same cell, and IgA, which entered the epithelial cell after synthesis in and secretion by a plasma cell.
Raised Skin Temperature in the Early Diagnosis of Deep-vein Thrombosis of the Legs
Authors: J. L. Provan
Journal: BMJ (1965)

The reported incidence of deep-vein thrombosis in hospital patients varies from less than 1 % (Barker et al., 1940 ; Felder, 1949) to over 28% (Sevitt and Gallagher, 1959).This wide variation reflects not only differences in the populations at risk but also differences in the criteria of diagnosis and in the vigilance with which they are sought.There is general agreement that the clinical diagnosis of deep-vein thrombosis may be difficult or impossible, and the occurrence of pulmonary embolism without previous recognition of its cause is common experience.The usually accepted signs of deep-vein thrombosis are oedema, calf tenderness on pressure or on dorsiflex on of the ankle, and tenderness over the femoral vein.Some authors add cyanosis of the limb and dilated superficial veins, and a few mention raised temperature of the affected limb.Delayed cooling on exposure of the limb as an early sign of venous thrombosis was first mentioned by Pilcher (1939), who stated, "I do not remember any patient showing this sign who did not develop others " (of deep-vein thrombosis).This paper reports an attempt to assess the value of this physical sign.The investigation was planned to answer three questions: (1) What other factors than deep-vein thrombosis can cause delayed cooling on exposure ? (2)In the absence of such factors is delayed cooling a reliable early sign of deep-vein thrombosis ?(3) Is delayed cooling always followed by other physical signs of deep-vein thrombosis ?Patients During a period of six months 514 patients in an adult male and an adult female ward were examined in the manner described below, 3,950 observations being made.The patients comprised a group of general surgical cases, including emergencies and cold surgery, together with some thoracic and vascular cases.Orthopaedic and genito-urinary cases were not usually resident in these wards and only a few are included in the series.Eight of the 28 beds in the male ward were occupied by patients receiving radiotherapy for malignant disease.Many of these were ill and confined to bed.Patients with dressings or bandages on the legs were excluded. MethodEach patient was examined at least every other day, th._ majority every day.The patient being supine, both legs were extended with the feet wide apart and uncovered to above the knee.Particular care was taken to ensure that the legs were not crossed and that the pat-ent was not lying on his side, and to see that there was no constriction of the thighs by clothing.The legs were thus exposed for about 10 minutes, after which the observer, using one hand, relt the skin around both ankles and noted any difference of temperature.The result was recorded simply as right warmer than left, or vice versa, or no difference.The presence of associated local signs of deep venous thrombosis was also recorded, together with the
Noninvasive ventilation reduced need for intubation in elderly patients with acute hypercapnic respiratory failure
Authors: Francis Whalen
Journal: Annals of Internal Medicine (2012)

Source Citation Nava S, Grassi M, Fanfulla F, et al. Non-invasive ventilation in elderly patients with acute hypercapnic respiratory failure: a randomised controlled trial. Age Ageing. 2011;40:444-50. 21345841
Less Toxic Treatment for Advanced Breast Cancer
Authors: I. Craig Henderson
Journal: New England Journal of Medicine (1981)

A variety of endocrine manipulations have long been used effectively to treat patients with metastatic breast cancer. It is puzzling why the same tumor should respond to the administration of different types of female hormones or male hormones and also to the ablation of hormones by oophorectomy, hypophysectomy, or adrenalectomy. If a premenopausal woman responds to oophorectomy, she is likely to respond a second time to adrenalectomy, presumably because adrenalectomy further reduces the circulating estrogen that the tumor needs as a growth factor. Adrenalectomy and hypophysectomy are widely accepted therapies in spite of their considerable complications because they have repeatedly . . .
DYSGAMMAGLOBULINEMIA TYPE I
Authors: MARSHALL B. BLOCK
Journal: Annals of Internal Medicine (1968)

Letters and Comments1 August 1968DYSGAMMAGLOBULINEMIA TYPE IMARSHALL B. BLOCKMARSHALL B. BLOCKSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-69-2-403_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: I would like to disagree with a statement made by the authors of the paper entitled, "'Asymptomatic' Type I Dysgammaglobulinemia in Siblings" (Ann. Intern. Med. 68: 867, 1968).They state in partial support for their argument that congenital hypogammaglobulinemia (Bruton type) is a distinct entity separable on genetic grounds from dysgammaglobulinemia type I, that "females with an antibody-deficiency syndrome have been reported." This in no way negates sex-linked inheritance as it is possible for a marriage of a female carrier and a male with Bruton's disease to produce a female with this disorder. Admittedly this would be... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York Medical College 103-30 68th Avenue Forest Hills, N. Y. 11375 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byFunctions Containing One Phosphorus and Either Another Phosphorus or As, Sb, Bi, Si, Ge, B or a MetalReferences to Volume 4Monomers, Initiators, and Solvents 1 August 1968Volume 69, Issue 2Page: 403-403KeywordsGenetics Issue Published: 1 August 1968 PDF downloadLoading ...
Extramedical Influence of the Physician
Authors: George L. Marthy
Journal: JAMA (1963)

<h3>To the Editor:</h3> —The article entitled "Extramedical Influence of the Physician" (<i>JAMA</i><b>181</b>:393 [Aug 4] 1962) warrants some comments and criticism. I'm afraid I must take a contrary view to Dr. Barach's recommendation and hold the opinion that doctors should advise their patients in areas of morality, applying repressive recommendations to momentary pleasures—indulgence in which, ultimately causes more severe neurosis than their inhibition. First of all, the argument that religion represses true pleasurable impulses that are good is totally unsupported by any factual data and is therefore in complete error. Furthermore, the generalization that inhibition of evil impulses causes neurosis is revived from its morbid stagnation and is used to support this argument about the undesirability of the repressiveness of religion. Nowhere are any particular points made to support these contentions. The only particulars presented are in relation to smoking and drinking, which have little bearing on religious and
Estimation of the time component in the movement of chemicals in contaminated groundwater.
Authors: S C Freni, D L Phillips
Journal: Environmental Health Perspectives (1987)

For a proper analysis of the potentially causal relationship between exposure to volatile organic chemicals (VOCs) in drinking water and health events, it is essential to know T1, the time when exposure started, and C = f(T), which is the change of the VOC concentration C as a function of time T and the total accumulated exposure (TAE) to VOCs to which an individual was exposed. In the typical situation of incidentally detected pollution of groundwater, no such information is available. This paper describes the development of a method for estimating T1, C = f(T), and TAE as part of an epidemiologic study of the health effects of VOC contamination of an aquifer serving public and private wells. Pooled test results of city wells, tested periodically since 1981, provided the data base for developing a statistical model for estimating C = f(T). This model was then applied to private wells, for which the data of only one water sample were available, to retrospectively estimate their T1. The best-fitting model was a multiple linear regression equation consisting of the natural logarithm of the VOC concentration as the response variable, with the time of sampling, the distance of the wells from the source (expressed as coordinates), the well depth, and the well capacity as determinants. The TAE was calculated by integrating the area under the time-concentration curve.
Intravenous amiodarone for recurrent sustained hypotensive ventricular tachyarrhythmias
Authors: Joseph H. Levine, Ali Massumi, Melvin M. Scheinman, Roger A. Winkle, Edward V. Platia, Donald A. Chilson, J. Anthony Gomes, Raymond L. Woosley
Journal: Journal of the American College of Cardiology (1996)

We sought to determine the response rate and safety of intravenous amiodarone in patients with ventricular tachyarrhythmias refractory to standard therapies. Numerous small retrospective reports suggest a response of refractory ventricular tachyarrhythmias to intravenous amiodarone, yet no controlled prospective trials exist. Two hundred seventy-three patients with recurrent hypotensive ventricular tachyarrhythmias refractory to lidocaine, procainamide and bretylium were randomized to receive one of three doses of intravenous amiodarone: 525, 1,050 or 2,100 mg/24 h (mean [±SE] dose 743.7 ± 418.7, 1,175.2 ± 483.7, 1,921.2 ± 688.8 mg, respectively) by continuous infusion over 24 h. Of the 273 patients, 110 (40.3% response rate) survived 24 h without another hypotensive ventricular tachyarrhythmic event while being treated with intravenous amiodarone as a single agent (primary end point). A significant difference in the time to first recurrence of ventricular tachyarrhythmia (post hoc analysis) over the first 12 h was observed when the combined 1,050- and 2,100-mg dose groups were compared with the 525-mg dose group (p = 0.046). The number of supplemental (150 mg) infusions of intravenous amiodarone (given for breakthrough destabilizing tachyarrhythmias) during hours 0 to 6 (prespecified secondary end point) was significantly greater in the 525-mg dose group than in the 2,100-mg dose group (1.09 ± 1.57 vs. 0.51 ± 0.97, p = 0.0043). However, there was no clear dose-response relation observed in this trial with respect to success rates (primary end point), time to first recurrence of tachyarrhythmia (post hoc analysis) or mortality (secondary end point) over 24 h. Intravenous amiodarone is a relatively safe therapy for ventricular tachyarrhythmias refractory to other medications.
Selective ECG synchronised suction and retroinfusion of coronary veins: first results of studies in acute myocardial ischaemia in dogs
Authors: P. Boekstegers, J. Diebold, C. Weiss
Journal: Cardiovascular Research (1990)

Journal Article Selective ECG synchronised suction and retroinfusion of coronary veins: first results of studies in acute myocardial ischaemia in dogs Get access Peter Boekstegers, Peter Boekstegers Correspondence to: Dr Boekstegers, at Medizinische Klinik I, Klinikum Grosshadern, Ludwig Maximilians Universität München, Marchioninistr. 15, 8000 München 70, West Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Joachim Diebold, Joachim Diebold Search for other works by this author on: Oxford Academic PubMed Google Scholar Christoph Weiss Christoph Weiss Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 24, Issue 6, June 1990, Pages 456–464, https://doi.org/10.1093/cvr/24.6.456 Published: 01 June 1990 Article history Received: 06 November 1989 Accepted: 15 March 1990 Published: 01 June 1990
SPECT in the Management of Patients With Back Pain and Spondylolysis
Authors: JANE A. E. DUTTON, SEAN P. F. HUGHES, ADRIEN M. PETERS
Journal: Clinical Nuclear Medicine (2000)

Single photon emission computed tomography (SPECT) bone scans of the lumbar spine were evaluated in the management of patients with low back pain and suspected spondylolysis.Thirty-three patients (mean age, 30 years) with high clinical suspicion of pars interarticularis defects were included in the study. The results of lumbar radiographs and SPECT bone scintigraphy were compared and the influence of these results on patient management was evaluated.Twenty-six of the 33 patients had abnormal results of lumbar radiographs. Of the 21 patients with radiographs indicating spondylolysis, six had abnormal uptake in the pars regions on bone scintigraphy. One patient with normal results of lumbar radiographs had a SPECT bone scan showing uptake in the region of the pars interarticularis.SPECT bone scanning of the lumbar spine has a role in the treatment of patients with symptomatic spondylolysis.
382. Expanding the Repertoire of Heterospecific LoxP Sites for Cre-Mediated Site-Specific Recombination
Authors: Stephen J. Langer, Jarred Keith, Leslie A. Leinwand
Journal: Molecular Therapy (2005)

Cre recombinase catalyzes site-specific recombination between 34 bp elements called lox sites. Each lox site consists of two 13 bp palindromic arms, which serve as recombinase binding sites, separated by an 8 bp asymmetric spacer region, which serves as the active site of strand exchanges during recombination. Studies have shown that this spacer region not only confers directionality to the lox site, but provides an additional level of specificity. This has led to the discovery of heterospecificity as a property of certain lox sites whose spacer sequences differ. Functionally, heterospecificity can be defined as the inability of two different lox sites to recombine with one another when linked in cis in the presence of the recombinase, but are otherwise capable of undergoing productive recombination reactions with lox sites with which they share spacer identity. Such sites are particularly useful for carrying out Recombinase-Mediated Cassette Exchange (RMCE) reactions, a method for precisely manipulating DNA in vivo.
An angiotensin II receptor antagonist attenuates left ventricular dilatation after myocardial infarction in the hypertensive rat
Authors: T. Nishikimi, H. Yamagishi, K. Takeuchi, T. Takeda
Journal: Cardiovascular Research (1995)

Journal Article An angiotensin II receptor antagonist attenuates left ventricular dilatation after myocardial infarction in the hypertensive rat Get access Toshio Nishikimi, Toshio Nishikimi * First Department of Internal Medicine, Osaka City University Medical School, Osaka, Japan *Correspondence to Dr Nishikimi, at Division of Hypertension and Nephrology, National Cardiovascular Centre, 5-7-1, Fujishiro-dai, Suita, Osaka 565, Japan. Search for other works by this author on: Oxford Academic PubMed Google Scholar Hiroyuki Yamagishi, Hiroyuki Yamagishi First Department of Internal Medicine, Osaka City University Medical School, Osaka, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Kazuhide Takeuchi, Kazuhide Takeuchi First Department of Internal Medicine, Osaka City University Medical School, Osaka, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Tadanao Takeda Tadanao Takeda First Department of Internal Medicine, Osaka City University Medical School, Osaka, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 29, Issue 6, June 1995, Pages 856–861, https://doi.org/10.1016/S0008-6363(96)88623-8 Published: 01 June 1995 Article history Received: 16 June 1994 Accepted: 06 February 1995 Published: 01 June 1995
Human enterocyte (Caco-2) migration is modulated in vitro by extracellular matrix composition and epidermal growth factor.
Authors: M D Basson, I M Modlin, J A Madri
Journal: Journal of Clinical Investigation (1992)

The modulation of enterocyte sheet migration was studied using Caco-2 cells, a well-differentiated human colonic cell line. Although Caco-2 cells attached and spread equivalently over collagen types I, III, IV, and V and laminin, migration over laminin was significantly slower than migration over the collagen types. Fibronectin was a poor substrate for attachment, spreading, and migration. Epidermal growth factor (EGF) stimulated migration over laminin but did not alter Caco-2 migration over collagen or fibronectin. This effect was independent of cell proliferation, which was stimulated equivalently on both laminin and collagen I. Expression and organization of cell surface receptors for matrix (integrins) were studied using antibodies specific for beta and alpha integrin subunits. Integrin surface expression was assessed by immunoprecipitation of surface 125iodinated control and EGF-treated cells. Beta 1 surface pools did not change substantially in any condition studied. Alpha 1 subunit pools were decreased after EGF treatment on collagen I but alpha 1 pools increased after EGF treatment on laminin. Surface pools of alpha 2 subunits were increased following EGF treatment whether cells were cultured on laminin or collagen I. However, traditional immunofluorescent and laser confocal imaging demonstrated substantial differences in the character of alpha 2 subunit organization between collagen and laminin in the migrating cell front. Furthermore, a functional antibody to the alpha 2 subunit inhibited EGF stimulation of migration over laminin without substantial effects on basal migration over laminin or collagen I. Thus, EGF appears to exert a matrix-specific effect on enterocyte migration by modulation of integrin expression and organization.