tbuckley/cabot-search huggingface dataset:
Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma
Authors: Eranga N Vithana, Chiea-Chuen Khor, Chunyan Qiao, Monisha E Nongpiur, Ronnie George, Li-Jia Chen, Tan Do, Khaled Abu-Amero, Chor Kai Huang, Sancy Low, Liza-Sharmini A Tajudin, Shamira A Perera, Ching-Yu Cheng, Liang Xu, Hongyan Jia, Ching-Lin Ho, Kar Seng Sim, Ren-Yi Wu, Clement C Y Tham, Paul T K Chew, Daniel H Su, Francis T Oen, Sripriya Sarangapani, Nagaswamy Soumittra, Essam A Osman, Hon-Tym Wong, Guangxian Tang, Sujie Fan, Hailin Meng, Dao T L Huong, Hua Wang, Bo Feng, Mani Baskaran, Balekudaru Shantha, Vedam L Ramprasad, Govindasamy Kumaramanickavel, Sudha K Iyengar, Alicia C How, Kelvin Y Lee, Theru A Sivakumaran, Victor H K Yong, Serena M L Ting, Yang Li, Ya-Xing Wang, Wan-Ting Tay, Xueling Sim, Raghavan Lavanya, Belinda K Cornes, Ying-Feng Zheng, Tina T Wong, Seng-Chee Loon, Vernon K Y Yong, Naushin Waseem, Azhany Yaakub, Kee-Seng Chia, R Rand Allingham, Michael A Hauser, Dennis S C Lam, Martin L Hibberd, Shomi S Bhattacharya, Mingzhi Zhang, Yik Ying Teo, Donald T Tan, Jost B Jonas, E-Shyong Tai, Seang-Mei Saw, Do Nhu Hon, Saleh A Al-Obeidan, Jianjun Liu, Tran Nguyen Bich Chau, Cameron P Simmons, Jin-Xin Bei, Yi-Xin Zeng, Paul J Foster, Lingam Vijaya, Tien-Yin Wong, Chi-Pui Pang, Ningli Wang, Tin Aung
Journal: Nature Genetics (2012)
Who Will Vote for the Uninsured in '96?
Authors: Rebecca Voelker
Journal: JAMA (1996)

THEY HELD the spotlight in 1992—tens of millions of uninsured Americans who told of their plight during public forums and in countless news stories. But in the 1996 presidential campaign, they are about as conspicuous as a polar bear in a snowstorm. Even though their ranks have increased in the last 4 years, to an estimated 40 million, the uninsured can expect little relief from either candidate as the calendar unfurls toward election day. "The marketplace solution being put forth by both parties does not address the needs of the uninsured," said Jeff Jacobs, director of congressional affairs for the American Public Health Association. President Bill Clinton late last month signed landmark legislation that provides long-sought job-to-job portability of health insurance and restricts the denial of coverage on the basis of preexisting conditions. But the bipartisan bill, for which both parties clamored to take credit, is designed to help
TCT-479 Impact of Left Ventricular Dysfunction and Multi-Vessel Disease After Primary Percutaneous Coronary Intervention: Three-Year Outcomes from the HORIZONS-AMI Trial
Authors: Benoit Daneault, Philippe Genereux, Ajay Kirtane, Bernhard Witzenbichler, Giulio Guagliumi, Jean-Michel Paradis, Martin Fahy, Roxana Mehran, Gregg Stone
Journal: Journal of the American College of Cardiology (2012)
Endoscopic Gallbladder Catheterisation and Extracorporeal Shockwave Lithotripsy in the Management of Mirizzi's Syndrome
Authors: D. F. Martin, D. E. F. Tweedle, P. N. Rao
Journal: Endoscopy (1988)

A novel approach to the management of Mirizzi's syndrome due to a mucocele of the gallbladder is reported. Endoscopic retrograde catheterisation of the gallbladder permitted decompression, and was followed by extracorporeal shockwave lithotripsy of gallbladder calculi in an 80-year-old man considered unfit for operation.
Controlled Comparison of the Efficacy of Fourteen Preparations in the Relief of Postoperative Pain
Authors: J. D. Morrison, W. B. Loan, J. W. Dundee
Journal: BMJ (1971)

Thirteen analgesic drugs, four of them at two dose levels, four analgesics in combination with antagonist or neuroleptic agents, and saline have been evaluated simultaneously in the relief of postoperative pain. The method of assessment was designed to favour drugs which provided freedom from pain with minimum depression of consciousness. Only levorphanol 2 mg proved significantly superior to pethidine 100 mg, which was used as the standard reference drug. Oxycodone 10 mg, pentazocine 20 mg, and the morphine 10 mg and cyclizine 50 mg combination were the most successful of the remaining drugs. None of the drug combinations was significantly better than the analgesic drug given alone.
Oral delivery of a potent anti-angiogenic heparin conjugate by chemical conjugation and physical complexation using deoxycholic acid
Authors: Farzana Alam, Taslim A. Al-Hilal, Seung Woo Chung, Donghyun Seo, Foyez Mahmud, Han Sung Kim, Sang Yoon Kim, Youngro Byun
Journal: Biomaterials (2014)
Comparison of topical glyceryl trinitrate with lignocaine ointment for treatment of anal fissure: A randomised controlled trial
Authors: J. Ahmad, S.I.H. Andrabi, M.A. Rathore
Journal: International Journal of Surgery (2007)

Topical glyceryl trinitrate (GTN) has gained popularity as a treatment for anal fissure in the West. In our country, lignocaine is still the current treatment for the entity. This study was done to compare the effect of GTN with lignocaine in terms of healing rate and recurrence in South Asian population.A prospective, double blinded, randomised controlled trial was conducted on 50 patients (both treatment arms included) of all ages and either gender with a clinical diagnosis of anal fissure. Group A was given 0.2% GTN ointment and Group B was given lignocaine ointment. Both subjective and objective signs of healing were assessed and adverse effects of the treatment were sought.Symptomatic relief was earlier with GTN as compared with lignocaine. Pain relief was steady and sustained in those treated with GTN but returned to pre-treatment status within 5 weeks in patients with lignocaine. After 8 weeks of treatment, 80% of patients in Group A showed clinical signs of healing compared to 32% in Group B (p=0.001). Headache was the main side effect of GTN. At 6-month follow-up, recurrence was seen in 3/8 patients in Group B compared to 8/20 in the GTN Group (p=1).Topical GTN has earlier and a higher rate of clinical healing of anal fissure with acceptable side effects. The recurrence rate is high and comparable to lignocaine ointment. It is a safe and an effective treatment of anal fissure in a South Asian population.
Genetic Models in Biomedical Investigation
Authors: Howard L. Bleich, Emily S. Boro, Heinz Valtin
Journal: New England Journal of Medicine (1974)

DURING the past 12 years, my colleagues and I have been studying laboratory animals with inherited defects that mimic human disease.1 , 2 We have found these genetic models to be useful in two major ways: animals with inherited defects can be studied as analogue models of human disease; and mutants and hybrids can be examined or produced in an effort to identify causes of disease.3 4 5 6 Both types of analysis have important implications for palliative and preventive medicine.Hypothalamic Diabetes InsipidusThe Brattleboro rat, discovered in our department in 1961,1 is born with hypothalamic diabetes insipidus. Each day it excretes up to . . .
Influence of the severity of rheumatoid arthritis on sex differences in health assessment questionnaire scores.
Authors: C M Deighton, D Surtees, D J Walker
Journal: Annals of the Rheumatic Diseases (1992)

In a study of 284 consecutive patients with rheumatoid arthritis attending hospital clinics a previous observation that female patients score higher on the Stanford Health Assessment Questionnaire (HAQ) than men was confirmed. A clinical disease severity score and the spread/severity index also showed that women had more severe disease. Although scores in some categories of the HAQ were higher in women, they were not disproportionately so, providing no evidence that domestic categories of the HAQ are biased against women. A multiple regression analysis showed that the spread/severity index score was the best predictor of HAQ scores, with sex making no significant contribution. The severity of the disease adequately explained the higher HAQ scores in female patients with rheumatoid arthritis.
Familial Idiopathic Cardiomegaly
Authors: WAYNE H. SCHRADER, GEORGE A. PANKEY, RICHARD B. DAVIS, ATHANASIOS THEOLOGIDES
Journal: Circulation (1961)

Two young adult sisters are described with clinical and pathologic findings of myocardial disease. These cases along with a suggestive family history are presented as examples of familial idiopathic cardiomegaly. Pathologic findings are compared and contrasted with those in the literature, and etiologic concepts are discussed. It is concluded that a congenital myocardial abnormality is the most likely etiology and suggestions for further studies are presented.
Respiratory Stimulants in Treatment of Perinatal Asphyxia
Authors: S. Godfrey, D. P. G. Bolton, K. W. Cross
Journal: BMJ (1970)

The effects of two analeptic drugs—taloximine and ethamivan—have been studied in asphyxiated fetal and newborn rabbits. In primary apnoea ethamivan reduced the time before the onset of gasping, while during gasping taloximine increased the gasp rate. In secondary apnoea neither drug initiated respiration, though most animals could be resuscitated by using intermittent positive pressure respiration. From these results it is suggested that analeptic drugs have no place in obstetric or neonatal departments.
SKIAGRAPHY OF THE SEMINAL DUCTS
Authors: WILLIAM T. BELFIELD
Journal: JAMA (1913)

Through an incision in the vas deferens just above the testicle (vasotomy), a solution of collargol or other metallic compound can be injected into vas and vesicle, and skiagrams made of these. Such pictures amplify our limited knowledge of the physiology and pathology of the vas deferens and seminal vesicle, and of the genital functions of the male.  The strength of the collargol should not exceed from 10 to 15 per cent.; the quantity injected at one sitting should in general be limited to 4 or 5 c.c.; injection should immediately cease if pain in groin or rectum occurs, since such pain shows irritation of vas or vesicle, sometimes requiring mitigation by morphin. If the vas be occluded by stricture, severe pain may be caused by the injection of even 1 or 2 c.c. Regurgitation of collargol into the connective tissue around the opening in the vas follows overdistention, and
Does metabolic bone disease follow truncal vagotomy and gastrojejunostomy?
Authors: K McKeown
Journal: BMJ (1984)

<h3>Abstract</h3> Insomnia Disorder is the most prevalent sleep disorder, and it involves both sleep difficulties and daytime complaints. The neural underpinnings of Insomnia Disorder are poorly understood. Several existing neuroimaging studies focused on local measures and specific regions of interests, which makes it difficult to judge their whole-brain significance. We therefore here applied a data-driven approach to assess differences in whole-brain structural connectivity between adults with Insomnia Disorder and matched controls without sleep complaints. We used diffusion tensor imaging and probabilistic tractography to assess whole-brain structural connectivity and examined group differences using Network-Based Statistics. The results revealed a significant difference in the structural connectivity of the two groups. Participants with Insomnia Disorder showed reduced connectivity in a subnetwork that included mainly fronto-subcortical connections with the insula as a key region. By taking a whole-brain network perspective, our study enables the integration of previous inconsistent findings. Our results reveal that reduced structural connectivity of the left insula and the connections between frontal and subcortical regions are central neurobiological features of Insomnia Disorder. The importance of these areas for interoception, emotional processing, stress responses and the generation of slow wave sleep may help guide the development of neurobiology-based models of the prevalent condition of Insomnia Disorder.
Ribonucleic Acid Metabolism in Mammalian Cells
Authors: Sheldon Penman
Journal: New England Journal of Medicine (1967)

THE last few years have witnessed rapid advances in the study of macromolecular metabolism of cells of higher organisms. Research in this area is sometimes called "molecular cell biology." It is hoped that the growing understanding of the basic processes in the cells will eventually contribute to the management of problems arising from aberrations in normal cell metabolism, such as the transition to uncontrolled cellular growth in tumor development and the conversion of the cellular synthetic capacity to the manufacture of viral specific products in the virus–infected cell.This article is concerned primarily with the role of one cellular macromolecule, . . .
A time for global health
Authors: R. Smith
Journal: BMJ (2002)

The life expectancy of the 642 million people in sub-Saharan Africa is 51 years, 27 years less than that of those who live in rich countries. Mortality among those aged under 5 is 25 times higher in Africa than in rich countries. The World Health Organization's Commission on Macroeconomics and Health, which reported at the end of 2001, estimates that by 2010 about 8 million lives a year could be saved in low income countries by investing large sums and acting through simple and effective interventions. 1 2 But will it happen? The rich countries have a poor record in fulfilling their promises to poor countries. Nevertheless, a small group of people with considerable influence on global health who met recently in California agreed that the lives might be saved. Raising expectations too high could lead to huge disappointment, but the opportunities for substantial improvement in global health are probably better now than at any time in the past 20 years.

Perhaps because of the report of the Commission on Macroeconomics and Health health is “fashionable” with world leaders in a way that it never has been before. Some 60 world leaders—including both Fidel Castro and George Bush—vied with each other to emphasise their commitment to health at the recent meeting on development financing in Monterrey, Mexico. The general assembly of the United Nations for the first time last year devoted a session to a health topic—HIV and …
Abstract B69: SUMO-binding proteins as effectors and regulators of SUMO modification
Authors: Catherine M. Guzzo, Ijeoma Uzoma, Heng Zhu, Eric Cox, Seth Blackshaw, Michael J. Matunis
Journal: Cancer Research (2009)

Abstract SUMOs (Small Ubiquitin-related Modifiers) are reversibly conjugated to other proteins in the cell, thereby regulating a wide range of essential functions. Many of the functions regulated by SUMOylation are intimately tied to processes directly relevant to cancer, including maintenance of genome integrity and cell cycle regulation. Studies in the past several years have in fact linked SUMOylation to a variety of human cancers, including leukemia, prostrate, breast, and colon cancers. In addition, SUMOylation has a direct role in promoting cancer metastasis. Thus, developing a fundamental understanding of the signals and factors that regulate SUMOylation, as well as how SUMOylation affects protein function, has the potential to lead to important new insights into cancer development, diagnosis, and treatment. We hypothesize that the three SUMO paralogues expressed in vertebrate cells (SUMO-1, SUMO-2 and SUMO-3), as well as their polymeric forms, represent unique signals recognized by unique proteins. Moreover, we propose that SUMOylation often promotes interactions between modified proteins and downstream factors containing SUMO-interacting motifs (SIMs). To test this hypothesis, we have initiated high throughput studies to identify novel SUMO-1, SUMO-2 and SUMO-2 polymeric chain binding proteins. Using protein microarray analysis, we identified ∼400 mostly nuclear proteins, many with preferential affinity for specific SUMO paralogues. Among these 400 putative SUMO-binding proteins was a family of zinc finger proteins that we have determined to possess a novel SIM. This family includes human proteins ZNF261, ZNF198, ZNF237, ZNF262, and ZNF258 and each protein contains a stretch of unique tandem zinc fingers called MYM (myeloproliferative and mental retardation) domains. Although the exact functions of MYM-type zinc finger motifs are not known, proteins containing these motifs are linked to myeloproliferative syndromes, X-linked mental retardation, and transcriptional regulation. We have found that although ZNF261 contains four canonical SIMs, these SIMs do not mediate SUMO binding. Rather, analysis of a series of truncation mutants of ZNF261 revealed that the MYM-type zinc finger motifs are both necessary and sufficient for SUMO-binding. MYM-type zinc finger motifs represent only the second known class of SUMO-binding motifs. Citation Information: Cancer Res 2009;69(23 Suppl):B69.
THE DISTRIBUTION OF CHLORIDES IN THE BLOOD OF THE DOG AFTER EXPERIMENTAL INTESTINAL OBSTRUCTION
Authors: Russell L. Haden, Thomas G. Orr
Journal: The Journal of Experimental Medicine (1925)

THE RESULTS OF SIMULTANEOUS CHLORIDE DETERMINATIONS IN WHOLE BLOOD, IN PLASMA, AND IN CELLS OF THE DOG AFTER EXPERIMENTAL INTESTINAL OBSTRUCTION ARE PRESENTED, AND THE CHLORIDE CONTENT OF WHOLE BLOOD AND OF PLASMA IS COMPARED BY TWO METHODS OF ESTIMATION: the iodometric titration on protein-free filtrate, and the digestion technique of Van Slyke. The chloride as determined on protein-free filtrate checks closely with that as determined by the digestion procedure. The iodometric determination shows accurately the level of chlorides in the blood. The total change in the chloride store of the body is best reflected in determinations on whole blood. In intestinal obstruction the retained chloride is not present in the blood in some undetermined form.
Adhesion-promoting receptors on human macrophages recognize Escherichia coli by binding to lipopolysaccharide.
Authors: S D Wright, M T Jong
Journal: The Journal of Experimental Medicine (1986)

We report here that human macrophages bind Escherichia coli by recognizing bacterial lipopolysaccharide (LPS). Purified LPS was inserted into erythrocyte membranes, and the resulting LPS-coated red cells were bound by macrophages with the same temperature and cation dependence as observed for E. coli. When receptors for LPS were withdrawn from the plasma membrane by spreading the macrophages on LPS-coated surfaces, the binding of E. coli was blocked. We have also identified the receptors on macrophages that recognize LPS. Macrophages express three structurally homologous cell surface proteins, CR3, lymphocyte function-associated antigen (LFA-1), and p150,95. We used surface-bound monoclonal antireceptor antibodies to selectively remove these proteins from the apical surface of macrophages. We found that each of these proteins mediated the binding of E. coli to macrophages.
Anomalous Inferior Vena Cava Draining into the Left Atrium Associated with Intact Interatrial Septum and Multiple Pulmonary Arteriovenous Fistulae
Authors: HARRISON BLACK, GEORGE T. SMITH, WALTER T. GOODALE
Journal: Circulation (1964)

A 30-year-old woman with cyanotic heart disease due to anomalous drainage of the inferior vena cava into the left atrium in the presence of an intact interatrial septum is reported. The diagnosis was established during life and the defect was successfully corrected by open-heart surgery. The patient failed to survive due to associated multiple pulmonary arteriovenous fistulae. The embryology of the intracardiac defect, the pathophysiology of these fistulae, and the associated advanced pulmonary atherosclerosis are discussed.
Abstract 4369: Compound 1, a quinoxaline-based small molecule, regulates the cancer cell proliferantion by the down-regulation of maternal embryonic leucine zipper kinase gene expression in brain tumor cells.
Authors: Sang-Un Choi, Chi Hoon Park, Mansoor M. Ahmed, Stephen Yoo, Shin-Young Park, Kwangrok Kim
Journal: Cancer Research (2013)

Abstract Maternal embryonic leucine zipper kinase (MELK), a member of the snf1/AMPK family of serine-threonine kinase, was indicated in stem cell renewal, cell cycle progression. Recently, several groups reported that MELK expression level is highly correlated with malignancy of a variety of tumors and its expression in the cancer cells is a negative factor of radiotherapy in cancer patients. Therefore, MELK can be a good target for cancer drug development. Previously, we tested the neuronal cell differentiation by the compound-1, a quinoxaline-based small molecule, with rat mesenchymal stem cells, and we found that the gene expression level of MELK is dramatically decreased in the differentiated cells in comparison with the parental stem cells. Based on this phenomenon, we checked the MELK gene expression in the several central nerve system cancer cell lines such as U87MG, XL498 and SNB19, and examined the change of the gene expression level by treatment of compound 1. All the cancer cells tested in this study expressed the MELK gene and its expression level is significantly decreased by the treatment of 20 uM compound 1. To confirm the relationship between the MELK gene expression and cell proliferation in brain tumor cells, we transfected the MELK gene to the U87MG cells and tested the cell growth rate in the presence or absence of compound 1 in comparison with parental cells. The cell growth rate of MELK gene-transfected cancer cells increased in comparison with the non-transfected control cells, and its overexpression can recover the down-regulation of the cell proliferation by treatment of compound 1. Meanwhile, the treatment of MELK gene siRNA decreased the cell proliferation rate of the U87MG cells in time dependent manner. In the cell cycle analysis, compound 1 induced both the increase of apoptotic cell rate from less than 5% to 22% and the decrease of G0/G1 phase U87MG cells in comparison with control. Meanwhile, the S and G2/M phase is not changed by the treatment of compound 1 in the U87MG cells. These results support MELK has an effect on regulation of cancer cell proliferation, and it may be a good target for cancer drug development. Citation Format: Sang-Un Choi, Chi Hoon Park, Mansoor M. Ahmed, Stephen Yoo, Shin-Young Park, Kwangrok Kim. Compound 1, a quinoxaline-based small molecule, regulates the cancer cell proliferantion by the down-regulation of maternal embryonic leucine zipper kinase gene expression in brain tumor cells. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4369. doi:10.1158/1538-7445.AM2013-4369