tbuckley/cabot-search huggingface dataset:
A database on dyspepsia.
Authors: G P Crean, R J Holden, R P Knill-Jones, A D Beattie, W B James, F M Marjoribanks, D J Spiegelhalter
Journal: Gut (1994)

A prospective study of dyspepsia was carried out in a primary referral hospital between 1974-1987 including 1540 patients of whom 1433 were seen as outpatients. The study protocol was agreed in advance and a structured questionnaire was used to elicit relevant clinical information: up to three diagnoses were permitted for each patient. The commonest principal diagnoses were duodenal ulcer (26%), functional dyspepsia (22%), and irritable bowel syndrome (IBS) (15%); alcohol related dyspepsia (4%) was as common as gastric carcinoma or symptomatic gall stones. Multiple diagnoses were common (31% given two diagnoses, and 6% given three) so that in all 2111 diagnoses were given to 1540 patients; the functional disorders (IBS and functional dyspepsia) considered together accounted for 39% of all diagnoses made. Whereas organic conditions were diagnosed by clinicians with confidence (63-98% considered 9certain9), even when given as the principal or first diagnosis IBS was considered 9certain9 in only 61% and functional dyspepsia 48%. The demographic symptom data, together with information on tobacco and alcohol use, and work lost are described in detail.
Neurological Outcome in Cold Water Drowning
Authors: Richard S. K. Young
Journal: JAMA (1980)

It is widely believed that the child who drowns and is in cardiopulmonary arrest on arrival at the emergency room will probably suffer severe neurological sequelae despite resuscitation. In cases of cold water drowning, however, hypothermia (less than 32 degrees C) may confer substantial protection to the CNS if the basic hypoxic state can be readily reversed.
Synergistic effects of nanotopography and co-culture with endothelial cells on osteogenesis of mesenchymal stem cells
Authors: Jangho Kim, Hong Nam Kim, Ki-Taek Lim, Yeonju Kim, Shambhavi Pandey, Pankaj Garg, Yun-Hoon Choung, Pill-Hoon Choung, Kahp-Yang Suh, Jong Hoon Chung
Journal: Biomaterials (2013)
DIAGNOSIS AND TREATMENT OF BELL'S PALSY
Authors: William Bierman
Journal: JAMA (1952)

In addition to inability to move the muscles of one side of the face, the patient with Bell's palsy may present other symptoms. The one most frequently encountered is pain; this may be experienced prior to, concomitantly with, or subsequent to the onset of paralysis. It may vary in intensity and duration from relatively mild and transient to, rarely, severe and persistent. The location of the pain can be auricular, postauricular or preauricular. When, during the performance of operations on the ears of patients who were conscious, I applied electric stimulation to the bony inner tympanic wall where the tympanic nerve (Jacobson's nerve) and some of its branches are located these patients complained of pain that was varyingly referred to the three regions mentioned. Another common symptom is epiphora, which may be due to ectropion and to increased secretion. Other eye disturbances include blurred vision and a burning sensation, occurring
Genome Sequence Comparison Reveals Independent Inactivation of the Caspase-15 Gene in Different Evolutionary Lineages of Mammals
Authors: Leopold Eckhart, Aumaid Uthman, Wolfgang Sipos, Erwin Tschachler
Journal: Molecular Biology and Evolution (2006)

We have recently demonstrated that placental mammalian species such as pig and dog express a novel proapoptotic protease, caspase-15, whereas mouse and humans lack this enzyme. Here we investigated the evolutionary fate of the caspase-15 gene in different mammalian lineages by analyzing whole-genome shotgun sequences of 30 mammalian species for the presence of caspase-15 orthologs. Caspase-15 gene sequences were found in representatives of all major mammalian clades except for the superorders Afrotheria (tenrec, rock hyrax, and elephant) and Euarchontoglires (rodents, rabbit, tree shrew, and primates), which either lacked any caspase-15-like sequences or contained mutated remnants of the caspase-15 gene. Polymerase chain reaction screenings confirmed the results of the database searches and showed that the caspase-15 gene is expressed not only in various placental mammals but also in the marsupial, Monodelphis domestica. The observed species distribution implies that caspase-15 has originated in an early ancestor of modern mammals and has been conserved, over more than 180 Myr, in marsupials and many placental mammals, whereas it was independently lost in 2 phylogenetically distant clades of placental mammals, that is, Afrotheria and Euarchontoglires. Our data suggest that the inactivation of the caspase-15 gene was not counteracted by, and may even have been driven by, evolutionary constraints in these clades, and therefore, caution against the uncritical use of gene absence for the inference of phylogenetic relationships.
724-4 Coexistence of Typical and Atypical Atrio-ventricular Nodal Reentry: Evidence for Multiple Pathways of Slow Conduction
Authors: Marco Zardini, Noel G. Boyle, Kevin M. Monahan, Panos Papageorgiou, Mark E. Josephson, Claudio D. Schuger
Journal: Journal of the American College of Cardiology (1995)
465 Black patients infected with HCV genotype 1 have a lower sustained viral response (SVR) rate to therapy with interferon + ribavirin than white patients, and this is explained by their lower neutrophil count. A prospective multicenter study of 813 U.S. Vete
Authors: N. Brau, E.J. Bini, S. Currie, H. Shen, B.S. Anand, K.-Q. Hu, S.B. Ho, D. Johnson, W.N. Schmidt, P.D. King, R. Cheung, S.J. Rossi, L.J. Jeffers, T.L. Wright
Journal: Journal of Hepatology (2004)
Ventilatory effects on pulmonary vascular inflow and outflow patterns
Authors: S. RODBARD, H. MURAO
Journal: Cardiovascular Research (1977)

Ventilation of an isolated lung lobe modifies the rate of inflow into its pulmonary artery (Murao and Rodbard, 1971). The present studies show that ventilation also influences the rate of outflow from the pulmonary vein in a manner which differs significantly from the effects on the rate of inflow into the pulmonary artery. Since this difference between instantaneous inflow and outflow rates affects the calculation of vascular conductance (resistance) and its interpretation we have compared and analysed the effects of ventilation on simultaneous flow patterns in the pulmonary artery and vein.
Mustard allergy in children
Authors: F. Rancé, G. Dutau, M. Abbal M
Journal: Allergy (2000)

Background: Mustard allergy is not well known. This study aimed to assess its clinical features and other associated allergies, and to define skin prick tests (SPT), specific IgE, and dose response by oral food challenge. Methods: Our study investigated 36 children with positive mustard SPT. The diagnosis of mustard allergy was based on open or single‐blind, placebo‐controlled food challenge (SBPCFC). We compared the subjects to 22 controls. Results: The initial clinical features were atopic dermatitis (51.8%), and urticaria and/or angioedema (37%). Fifteen children were allergic (positive SBPCFC) and 21 children were nonallergic (negative SBPCFC). Symptoms after mustard ingestion started under 3 years of age in 53.3% of the subjects. There was no significant difference in the food allergies and associated inhalant allergen sensitizations between the two groups. In the allergic group, the mean wheal diameter for mustard SPT was 8.8 mm and the median concentration of mustard serum (s) IgE 14.8 kU/l. The mean cumulative reactive dose were 153 mg. Conclusions: Allergic reactions to mustard started early in life. Clinical symptoms were not severe in children. Mustard should be included in screening tests of food allergy in children.
Electrophysiological and inotropic effects of H 234/09 (almokalant) in vitro: a comparison with two other novel IK blocking drugs, UK-68,798 (dofetilide) and E-4031
Authors: C Abrahamsson, G Duker, C Lundberg, L Carlsson
Journal: Cardiovascular Research (1993)

Objective: The aim was to compare the electrophysiological and inotropic effects of the novel class III agents H 234/09, UK-68,798, and E-4031 in vitro. Methods: The electrophysiological effects were investigated by recording transmembrane action potentials in the isolated ventricular muscle and Purkinje fibres of the rabbit; effects on force (adjusted to the maximum isoprenaline response) and refractoriness were investigated in the isolated cat papillary muscle. Results: It was shown that all the drugs induced a concentration dependent prolongation of the action potential duration, which was much more pronounced in the Purkinje fibres than in the ventricular muscle. However, when compared at concentrations giving a 15% increase of the action potential duration in ventricular muscle, H 234/09 was significantly less effective in the Purkinje fibres than the other two drugs. In the cat papillary muscle all drugs induced an increase in force development. This increase tended to parallel the increase in effective refractory period. However, at prolongations of effective refractory period of more than approximately 50% the increase in developed force levelled off. Conclusions: All the class III agents investigated showed a positive inotropic effect, which may be of advantage when compared to conventional class I antiarrhythmic agents, which have cardiodepressent actions. Compared to UK-68,798 and E-4031, H 234/09 showed a less unfavourable profile in terms of dispersion of repolarisation, which theoretically may reduce the risk of arrhythmias associated with delayed repolarisation. However, this less unfavourable profile must, like the positive inotropic effect, ultimately be investigated in clinical trials. Cardiovascular Research 1993;27:861-867
Genes, the Heart and Destiny
Authors: Paul D. White
Journal: New England Journal of Medicine (1957)

Our remedies oft in ourselves do lie, Which we ascribe to Heaven.SO said Helena in a soliloquy in the first scene of the first act of William Shakespeare's All's Well That Ends Well.This is my text, much easier for us to subscribe to in this day and age than it was several centuries ago when with highly justified fatalism the same Shakespeare put into Hamlet's mouth the oft quoted lines:There's a divinity that shapes our ends, Rough-hew them how we will.In the paganism of ancient days the "fates" held sway, as in the case of . . .
Epidemiology of fungal skin and nail disease: Roundtable Discussion held at Dermatology 2000, Vienna, 17 May 1993
Authors: Y.M. CLAYTON, R.J. HAY
Journal: British Journal of Dermatology (1994)

Journal Article Epidemiology of fungal skin and nail disease: Roundtable Discussion held at Dermatology 2000, Vienna, 17 May 1993 Get access Y.M. CLAYTON, Y.M. CLAYTON St John's Institute of Dermatology, St Thomas' Hospital, London, U.K. Dr Y.M.Clayton, St John's Institute of Dermatology.St Thomas' Hospital, London, U.K. Search for other works by this author on: Oxford Academic Google Scholar R.J. HAY R.J. HAY St John's Institute of Dermatology, St Thomas' Hospital, London, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 130, Issue s43, 1 April 1994, Pages 9–11, https://doi.org/10.1111/j.1365-2133.1994.tb06085.x Published: 01 April 1994
Curable Hypertension with Unilateral Hydronephrosis
Authors: PETER WEIDMANN
Journal: Annals of Internal Medicine (1977)

Among eight patients with unilateral hydronephrosis and hypertension, peripheral plasma renin activity was normal in seven and borderline high in one. Four patients had hydronephrotic/contralateral kidney renin ratios of greater than 1.5, suggesting excessive renin release from the diseased kidney, and ratios between contralateral kidney and peripheral blood of less than 1.2, indicating suppressed renin production in the contralateral kidney. Nephrectomy normalized blood pressure in each of these patients. Two patients had hydronephrotic/contralateral kidney renin ratios of less than or equal to 1.3 or contralateral kidney/periphery ratios of greater than 1.2, suggesting ischemia of the contralateral kidney; pyeloplasty or nephrectomy, or both, failed to improve the hypertension. Postoperative changes in blood pressure correlated with changes in peripheral renin (r = 0.90; P less than 0.01). These data suggest that hypertension associated with unilateral hydronephrosis is partly renin-dependent; and renal vein renin values are helpful in selecting patients for surgery.
Branched chain amino acids enhance the maturation and function of myeloid dendritic cells ex vivo in patients with advanced cirrhosis
Authors: Eiji Kakazu, Yoshiyuki Ueno, Yasuteru Kondo, Koji Fukushima, Masaaki Shiina, Jun Inoue, Keiichi Tamai, Masashi Ninomiya, Tooru Shimosegawa
Journal: Hepatology (2009)

An imbalance of plasma amino acids is observed in patients with advanced cirrhosis. The aim of this study was to investigate the influence of the extracellular amino acid imbalance on the function of myeloid dendritic cells (DCs) in patients with advanced cirrhosis. We made a serum-free culture medium consistent with the average concentration of plasma amino acids from healthy controls (HC, n = 25) or patients with advanced cirrhosis (LC, n = 43) to reflect more closely the actual environment of the living body. We compared the phenotypical and biological functions of blood dendritic cells antigen-positive dendritic cells (BDCA+ DCs) and monocyte-derived dendritic cells (MoDCs) from LC and HC with these media. After adding stimulants, the CD83 and CD86 expressions of DCs from LC were lower than those from HC. In both HC and LC, both CD83 and CD86 expressions of DCs stimulated under the cirrhotic medium were lower than under the control medium. This phenomenon was accompanied by a suppression of the mammalian target of rapamycin (mTOR)/S6K-signaling pathways. The interleukin 12 (IL-12) production in the cirrhotic medium was significantly lower than in the control medium and increased when valine or leucine was added to the medium. In patients with advanced cirrhosis, peripheral blood mononuclear cells stimulated in the autologous plasma after oral administration of branched-chain amino acid (BCAA) granules had significantly increased interferon gamma production. Conclusion: In advanced cirrhosis, there is impairment of the function and maturation of DCs, which has been shown to be related to an imbalance in the extracellular amino acid profile. Elevating the extracellular concentration of BCAAs ex vivo in patients with advanced cirrhosis improved the function of DCs. (HEPATOLOGY 2009.)
Rodent Thyroid, Liver, and Fetal Testis Toxicity of the Monoester Metabolite of Bis-(2-ethylhexyl) Tetrabromophthalate (TBPH), a Novel Brominated Flame Retardant Present in Indoor Dust
Authors: Cecilia Springer, Edward Dere, Susan J. Hall, Elizabeth V. McDonnell, Simon C. Roberts, Craig M. Butt, Heather M. Stapleton, Deborah J. Watkins, Michael D. McClean, Thomas F. Webster, Jennifer J. Schlezinger, Kim Boekelheide
Journal: Environmental Health Perspectives (2012)

Background: Bis-(2-ethylhexyl) tetrabromophthalate (TBPH) is widely used as a replacement for polybrominated diphenyl ethers (PBDEs) in commercial flame retardant mixtures such as Firemaster 550. It is also used in a commercial mixture called DP 45. Mono-(2-ethyhexyl) tetrabromophthalate (TBMEHP) is a potentially toxic metabolite.Objectives: We used in vitro and rodent in vivo models to evaluate human exposure and the potential metabolism and toxicity of TBPH.Methods: Dust collected from homes, offices, and cars was measured for TBPH by gas chromatography followed by mass spectrometry. Pregnant rats were gavaged with TBMEHP (200 or 500 mg/kg) or corn oil on gestational days 18 and 19, and dams and fetuses were evaluated histologically for toxicity. We also assessed TBMEHP for deiodinase inhibition using rat liver microsomes and for peroxisome proliferator-activated receptor (PPAR) α and γ activation using murine FAO cells and NIH 3T3 L1 cells.Results: TBPH concentrations in dust from office buildings (median, 410 ng/g) were higher than in main living areas in homes (median, 150 ng/g). TBPH was metabolized by purified porcine esterases to TBMEHP. Two days of TBMEHP exposure in the rat produced maternal hypothyroidism with markedly decreased serum T3 (3,3´,5-triiodo-l-thyronine), maternal hepatotoxicity, and increased multinucleated germ cells (MNGs) in fetal testes without antiandrogenic effects. In vitro, TBMEHP inhibited deiodinase activity, induced adipocyte differentiation in NIH 3T3 L1 cells, and activated PPARα- and PPARγ-mediated gene transcription in NIH 3T3 L1 cells and FAO cells, respectively.Conclusions: TBPH a) is present in dust from indoor environments (implying human exposure) and b) can be metabolized by porcine esterases to TBMEHP, which c) elicited maternal thyrotoxic and hepatotoxic effects and d) induced MNGs in the fetal testes in a rat model. In mouse NIH 3T3 L1 preadipocyte cells, TBMEHP inhibited rat hepatic microsome deiodinase activity and was an agonist for PPARs in murine FAO and NIH 3T3 L1 cells.
P476 SHORT-TERM (28-DAY) CLINICAL COURSE AND TRANSPLANT-FREE MORTALITY IN ACUTE ON CHRONIC LIVER FAILURE (ACLF); EVIDENCE FOR REVERSIBILITY OF ACLF (A STUDY FROM THE CANONIC DATABASE)
Authors: T. Gustot, J. Fernandez, E. Garcia, P. Ginès, R. Moreau, R. Jalan, M. Pavesi, F. Durand, P. Angeli, P. Caraceni, D. Markwardt, C. Alessandria, P. Solis Muñoz, W. Laleman, J. Trebicka, F. Saliba, S. Zeuzem, A. Albillos, L. Elkrief, D. Benten, J.L. Montero, M.T. Chiva, M. Concepcion, J. Cordoba, A. McCormick, R.E. Stauber, W. Vogel, A. de Gottardi, F. Morando, M. Domenicali, A. Gerbes, A. Risso, C. Deulofeu, M. Bernardi, V. Arroyo
Journal: Journal of Hepatology (2014)
Practice gazette in Leicestershire
Authors: A. Wilson, S. Jennings
Journal: BMJ (1994)

EDITOR,—We agree with M C Record and colleagues that, although practice annual reports are important internal documents, better sources of data exist for many activities involving other sectors.1 We also agree with most of the authors' respondents that comparative data are useful for practices.

In Leicestershire we recently started to produce and circulate a practice gazette that draws on family …
FACS analysis of Stat3/5 signaling reveals sensitivity to G-CSF and IL-6 as a significant prognostic factor in pediatric AML: a Children's Oncology Group report
Authors: Michele S. Redell, Marcos J. Ruiz, Robert B. Gerbing, Todd A. Alonzo, Beverly J. Lange, David J. Tweardy, Soheil Meshinchi
Journal: Blood (2012)
Hypersegmentation in Iron Deficiency Anemia
Authors: A. DOSCHERHOLMEN
Journal: JAMA (1974)

<h3>To the Editor.—</h3> Hypersegmented neutrophils, a hallmark of vitamin B<sup>12</sup>and folic acid deficiency, have also been found, for unknown reasons, in chronic renal disease and as a hereditary disorder. The neutrophil hypersegmentation observed in iron deficiency,<sup>1</sup>usually ascribed to an associated vitamin B<sub>12</sub>or folate deficiency, may also occur without laboratory evidence of deficiency of these vitamins. The reason for this morphologic change in iron deficiency is not known, but abnormalities in folate metabolism have been suggested. Thus, the urinary excretion of formiminoglutamic acid (FIGLU) is often increased in iron deficiency, and experimentally induced iron deficiency may lead to a secondary folate deficiency.<sup>2,3</sup> In patients with normal serum folate levels, it is possible that a subclinical folate deficiency exists, since iron therapy may induce a fall in serum folate concentrations. It has also been suggested that the enzymeFIGLU transferase is iron-dependent and, therefore, not functioning
A SALIVARY INDEX TO RENAL FUNCTION
Authors: PHILIP S. HENCH
Journal: JAMA (1923)

<h3>I. THE CLINICAL USE AND SIGNIFICANCE OF THE SALIVARY UREA INDEX</h3> That the determination of the blood urea is the most valuable test for estimating renal impairment with regard to retention of nitrogenous metabolites is generally recognized. However, the estimation of the blood urea, although a comparatively simple procedure if certain laboratory facilities are available, is too complicated and laborious for the use of the general practitioner. Urea is easily diffusible and is almost uniformly distributed in all tissues<sup>1</sup>and fluids of the body, including the spinal fluid and mammary gland excretion.<sup>2</sup>Myers and Fine<sup>3</sup>report that urea is present in the spinal fluid in 88 per cent, of its blood concentration. If standard solutions of urea are used, 93 per cent. will dialyze in twenty-four hours.<sup>4</sup> We have demonstrated in a previous paper<sup>5</sup>that the concentration of urea in saliva is practically the same
111In-Pentetreotide Uptake in an Ovarian Teratoma and Impact of SPECT/CT Imaging
Authors: Aurora Sainz-Esteban, Maria Luisa González, Alejandro Vara-Castrodeza, Paloma García-Talavera, Roberto Olmos, Maria Ángeles Ruiz, Claudia Gamazo, Antonio Gómez
Journal: Clinical Nuclear Medicine (2013)

We present a 19-year-old woman with a neuroendocrine tumor of the appendix diagnosed during an acute appendicitis. An 111In-pentetreotide scan was performed to establish the extension of the disease. Scintigraphy showed an abnormal focal uptake in the right side of the pelvis. The SPECT/CT images demonstrated a round-shaped mass in the right ovary. Pathology revealed a benign cystic mature teratoma. In our case, hybrid imaging combining SPECT and CT contributed to localize the unusual 111In-pentetreotide accumulation within the anatomical context.
Book Review Prisons and AIDS: A public health challenge (The Jossey–Bass Health Series.) By Ronald L. Braithwaite, Theodore M. Hammett, and Robert M. Mayberry. 247 pp. San Francisco, Jossey–Bass, 1996. $32.95. 0-7879-0308-6
Authors: Nancy Neveloff Dubler
Journal: New England Journal of Medicine (1997)
Preventing Patient Harms Through Systems of Care
Authors: Peter J. Pronovost, George W. Bo-Linn
Journal: JAMA (2012)

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September 11 leaves legacy of chronic ill health among US emergency medical workers
Authors: Z. Kmietowicz
Journal: BMJ (2015)

The September 11 attacks on the World Trade Center in 2001 have left a legacy of chronic ill health among emergency medical workers who attended the scene, a study reported in Occupational and Environmental Medicine has shown.1

The researchers, all from health services around New York City, found that those who arrived in the immediate aftermath of the attacks were most at risk of physical and mental ailments. Previous research has looked at the health effects of the disaster on firefighters and …