Amphotericin B Nephrotoxicity with Irreversible Renal Failure
Authors: FRANK J. TAKACS
Journal: Annals of Internal Medicine (1963)

Case Studies1 November 1963Amphotericin B Nephrotoxicity with Irreversible Renal FailureFRANK J. TAKACS, M.D., ZYGMUNT M. TOMKIEWICZ, M.D., JOHN P. MERRILL, M.D., F.A.C.P.FRANK J. TAKACS, M.D.Search for more papers by this author, ZYGMUNT M. TOMKIEWICZ, M.D.Search for more papers by this author, JOHN P. MERRILL, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-59-5-716 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe antifungal activity of amphotericin B, a polyene antibiotic synthesized byStreptomyces nodosus, has been documented adequately since its introduction into clinical use in 1956. It has been found effective in the treatment of a variety of systemic mycoses including North and South American blastomycosis, cryptococcosis, coccidioidomycosis, histoplasmosis, sporotrichosis, aspergillosis, chromoblastomycosis, and candidiasis (1-4). Clinical effectiveness has, however, been accompanied by a variety of disturbing side effects and evidences of toxicity. At some time during treatment most patients have experienced chills, fever, anorexia, nausea, vomiting, epigastric pain, myalgia, or headache (5-7). It has been suggested that the pyrogenic activity of...References1. UTZTREGER JPA: The current status of chemotherapy of systemic fungal disease. Ann. Intern. Med. 51: 1220, 1959. LinkGoogle Scholar2. SEABURYDASCOMB JHHE: Experience with amphotericin B. Ann. NY Acad. Sci. 89: 202, 1960. CrossrefMedlineGoogle Scholar3. NEWCOMERSTERNBERGWRIGHTREISNERMCNALLSORENSEN VDTHETRMEGLJ: The treatment of systemic fungus infections with amphotericin B. Ann. NY Acad. 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GIDDINGS TH: Fatal reaction to amphotericin B. Texas J. Med. 58: 183, 1962. MedlineGoogle Scholar10. WINN WA: The use of amphotericin B in the treatment of coccidioidal disease. Amer. J. Med. 27: 617, 1959. CrossrefMedlineGoogle Scholar11. LOURIA DB: Some aspects of the absorption, distribution, and excretion of amphotericin B in man. Antibiot. Med. 5: 295, 1958. Google Scholar12. SEABURYDASCOMB JHHE: Experience with amphotericin B for the treatment of systemic mycoses. Arch. Intern. Med. (Chicago) 102: 960, 1958. CrossrefGoogle Scholar13. HOLEMANEINSTEIN CWHE: Studies on the toxicology of amphotericin B. Transactions, Sixth Annual Meeting VA-Armed Forces Coccidioidomycosis Cooperative Study, edited by WAYNE, L. G., 1961, p. 36. Google Scholar14. HILLBUTLERWERTLAKEUTZ GJWTPTJP: The renal histopathology in amphotericin B toxicity in man and the dog: a study of biopsy and post-mortem specimens. Clin. Res. 10: 249, 1962. Google Scholar15. RHOADESGINNMUCHMORESMITHHAMMARSTEN ERHEHGWOJF: Effect of amphotericin B upon renal function in man. Clin. Res. 8: 232, 1960. Google Scholar16. ROBERTSRABSON WCAS: Focal glomerular lesions in fungal endocarditis. Ann. Intern. Med. 56: 610, 1962. LinkGoogle Scholar17. WINN WA: Personal communication. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: FRANK J. TAKACS, M.D.; ZYGMUNT M. TOMKIEWICZ, M.D.; JOHN P. MERRILL, M.D., F.A.C.P.Affiliations: Boston, MassachusettsFrom the Cardiorenal Laboratory, Department of Medicine and Department of Pathology, Peter Bent Brigham Hospital, and Harvard Medical School, Boston, Massachusetts.Dr. Takacs is a Research Fellow of the American Heart Association.Requests for reprints should be addressed to Frank J. Takacs, M.D., Kidney Laboratory, Peter Bent Brigham Hospital, 721 Huntington Avenue, Boston 15, Massachusetts. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHistorical Perspective of NephrotoxicityLarge-Scale Land Development, Fugitive Dust, and Increased Coccidioidomycosis Incidence in the Antelope Valley of California, 1999–2014Amphotericin B (AMB)Amphotericin BAmphotericin BAmphotericin BUpdate on Invasive CandidiasisIntralipid in Prophylaxis of Amphotericin B NephrotoxicityPathophysiology of experimental nonoliguric acute renal failureDictionary of Inorganic CompoundsToxic NephropathiesDrug-Induced Acute Renal FailureRenal Injury from Chemotherapeutic AgentsNephrotoxic Tubular and Interstitial Lesions: Morphology and ClassificationRenal magnesium wasting associated with amphotericin B therapyTherapy of Toxic NephropathiesAcute Renal FailurePrognosis and Prevention of Renal Failure Induced by ToxinsAn Appraisal of 12 Solutions Used for Bladder Irrigation or InstillationA Review of Complications of Amphotericin-B Therapy: Recommendations for Prevention and ManagementPathology of CoccidioidomycosisThe Nephrotoxicity of Antimicrobial AgentsThe surgical treatment of pulmonary coccidioidomycosisDrug-induced renal diseasesRenal Ultrastructure After Amphotericin BMucormycosis-Changing StatusNephrotoxicity of amphotericin B, with emphasis on changes in tubular functionCoccidioidomycosisCoccidioidomycosisOral amphotericin B in the treatment of ulcerative intestinal diseasesAmphotericin B Toxicity A Follow-up Report of 53 PatientsRAYMOND P. MILLER, M.D., JOSEPH H. BATES, M.D., F.A.C.P.Die HistoplasmoseDie HistoplasmoseNephrotoxic effects of amphotericin B, including renal tubular acidosisWilliam A. Winn: Some Recollections about a Great Clinician, a Great Scholar, and a Good FriendResidua from Systemic Candidiasis Treated with AmphotericinRenal Tubular Acidosis Due to Amphotericin BRhinocerebral Phycomycosis in Association with Diabetic Ketoacidosis Report of Two Cases and a Review of Clinical and Experimental Experience with Amphotericin B TherapyEUGENE ABRAMSON, M.D., DANA WILSON, M.D., RONALD A. ARKY, M.D.Toxic nephropathyPulmonary AspergillomaComplications associated with antibiotic therapyNephrotoxicity of Amphotericin B Early and Late Effects in 81 PatientsWILLIAM T. BUTLER, M.D., JOHN E. BENNETT, M.D., DAVID W. ALLING, M.D., PH.D., PAUL T. WERTLAKE, M.D., JOHN P. UTZ, M.D., GEORGE J. HILL II, M.D.Changes in Renal FunctionWILLIAM T. BUTLER, M.D. 1 November 1963Volume 59, Issue 5_Part_1Page: 716-724KeywordsAmphotericinAntifungalsCoccidioidomycosisFibrosisHospital medicineMeningitisMyalgiaToxicityTransplantationVomiting ePublished: 1 December 2008 Issue Published: 1 November 1963 PDF downloadLoading ...