High prevalence of undiagnosed COPD in a cohort of HIV-infected smokers
Authors: Alain Makinson, Maurice Hayot, Sabrina Eymard-Duvernay, Mylène Quesnoy, François Raffi, Laurence Thirard, Fabrice Bonnet, Pierre Tattevin, Sophie Abgrall, Xavier Quantin, Hervé Léna, Sébastien Bommart, Jacques Reynes, Vincent Le Moing
Journal: European Respiratory Journal (2014)

Studies in HIV-infected populations in developed countries have shown an increased prevalence of chronic obstructive pulmonary disease (COPD) in comparison with their HIV-uninfected counterparts [1, 2]. This is due in part to higher prevalence of smoking in these populations. Studies have included subjects with or without a history of smoking [3,4], specific populations ( e.g. history of intravenous drug use (IDU) [5]), and African-American or Hispanic minorities in the USA [4, 5]. Few studies have been performed in Europe [3]. When looking at HIV-related factors, history of Pneumocystis infection or colonisation [6], HIV viral load >200 000 copies·mL−1 [5] and antiretroviral therapy (ART) [4] were associated with COPD. However, further studies are needed. COPD prevalence is 26% in an HIV-infected cohort of smokers aged ≥40 years and was largely underdiagnosed <http://ow.ly/CkVzo> The members of the ANRS EP48 HIV CHEST Study Team are: Yazdan Yazdanpanah, Antoine Cheret, Faïza Ajana, Isabelle Alcaraz, Véronique Baclet, Hugues Melliez, Michel Valette, Nathalie Viget, Xavier de la Tribonniere, Thomas Huleux, Séverine Bonne, Raphaël Biekre, Armelle Pasquet, Christophe Allienne, Jean Marie Behra, Agnès Meybeck and Emmanuelle Aissi (Hôpital Gustave Dron, Tourcoing, France); Sophie Abgrall, Olivier Bouchaud, Régine Barruet, François Rouges, Tania Kandel, Fréderic Mechai, Pierre-Yves Brillet and Michel Brauner (Hôpital Avicenne, Bobigny, France); Pierre Dellamonica, Francine de Salvador, Eric Cua, Anne Leplatois, Alissa Naqvi, Jacques Durant, Carole Ceppi, Frédéric Sanderson, Eric Rosenthal, Madleen Chassang, Patrick Chevallier and Brigitte Dunais (Hôpital l'Archet, Nice, France); Pierre Tattevin, Hervé Lena, Pierre-Axel Lentz, Christian Michelet, Cédric Arvieux, Mathieu Revest, Faouzi Souala, Jean-Marc Chapplain, Hélène Leroy and Catherine Meunier (Hôpital Pontchailloux, Rennes, France); Isabelle Poizot-Martin, Olivia Faucher, Amélie Menard, Sylvie Bregigeon, Perrine Geneau de Lamarliere, Pierre Champsaur, Olivier Durieux and Nicolas Cloarec (Hôpital Ste Marguerite, Marseille, France); François Raffi, Clotilde Allavena, Nicolas Feuillebois, Olivier Mounoury, Sabelline Bouchez, Eric Billaud, Véronique Reliquet, Bénédicte Bonnet, Cécile Brunet, Patrick Point, David Boutoille, Pascale Morineau le Houssine and Anne Sophie Delemazure (Hôpital Hotel Dieu, Nantes, France); Claudine Duvivier, Emilie Catherinot, Michka Shoai Tehrani and Sylvain Poiree (Hôpital Necker, Paris, France); David Zucman, Catherine Majerholc, Louis-Jean Couderc, François Mellot and Antoine Sherrer (Hôpital Foch, Suresnes, France); Tristan Ferry, Joseph Koffi, André Boibieux, Patrick Miailhes, Laurent Cotte, Thomas Perpoint, Joanna Lippman, Claude Augustin Norman, Francois Biron, Agathe Senechar and Florence Ader (Hôpital La Croix Rousse, Lyon, France); Gilles Pialloux, Thomas l'Yavanc, Laurence Slama, Julie Chas, Sophie le Nagat, Antoine Khalil and Marie France Carette (Hôpital Tenon, Paris, France); Fabrice Bonnet, Philippe Morlat, Denis Lacoste, Marie VANDENHENDE, Marie Catherine Receveur, Francois Paccalin, Sabrina Caldato, Noëlle Bernard, Mojgan Hessemfar, Thierry Pistone, Denis Malvy, Pierre Thibaut, Marie Carmen Pertusa, Olivier Cornelou, Francois Laurent, Patrick Mercie, Isabelle Faure, Denis Dondia, Cedric Martell and Pierre Duffau (Hôpital St André, Bordeaux, France); Jean Marc Mauboussin, Claudine Barbuat, Isabelle Rouanet and Liliane Metge (Hôpital Carémeau, Nimes, France); and Jacques Reynes, Vincent le Moing, Jean-Marc Jacquet, Nadine Atoui, Mickael Loriette, David Morquin, Vincent Fauchere, Carine Favier, Corinne Merle, Vincent Baillat, Antoine da Silva, Rachid Mansouri, Christina Psomas, Sébastien Bommart, Hélène Kovacsik-Vernhet, Jean-Louis Pujol, Xavier Quantin and Maurice Hayot (Hôpital Gui de Chauliac, Montpellier, France). This study was presented in part at the 21st Conference on Retrovirus and Opportunistic Infections in Boston, MA, USA, between March 3 and 6, 2014. We thank the trial participants, and the coordinators, engineers and technicians who made this study possible: Suzanne Izard, Jonathan Lalet, Amandine Cournil and Bruno Granouillac (UMI 233, IRD, University Montpellier 1, Montpellier, France).