tbuckley/cabot-search huggingface dataset:
Controversial allergy doctor is given formal warning by GMC
Authors: C. Dyer
Journal: BMJ (2012)

A controversial allergy doctor has been given a formal warning by the General Medical Council after her fitness to practise was found to be “on the cusp of a finding of impairment.”

Jean Monro was found guilty of misconduct for practising beyond her competence and giving a patient inappropriate and potentially harmful chelation therapy for lead poisoning on the basis of a diagnosis that involved “inappropriate and ineffective” tests.

Monro, who qualified in 1960, saw the patient, “HB,” at Breakspear Hospital, a private day hospital …
The Diary of Vaslav Nijinsky
Authors: A. Sommerlad
Journal: BMJ (2012)

During early 1919, overwhelmed by turmoil about the end of his career, devastation at the recent war, and deep mental distress fostered throughout his life, the virtuoso ballet dancer Vaslav Nijinsky became consumed by psychosis. He documented this experience in his remarkable diary, written over a frantic six weeks. Nijinsky’s private exploration of his dreams, anguish, and paranoia is an enlightening read, the more so because his subsequent story tells us much about the development of psychiatric treatment.

For a man who found global fame with the Ballet Russes during the early 20th century, …
Interrelations of calcium-regulating hormones during normal pregnancy.
Authors: M Whitehead, G Lane, O Young, S Campbell, G Abeyasekera, C J Hillyard, I MacIntyre, K G Phang, J C Stevenson
Journal: BMJ (1981)

Profound changes in calcium metabolism occur during pregnancy. The mother has to make available extra calcium for fetal requirements while ensuring that her plasma and bone calcium concentrations are satisfactorily maintained. In a cross-sectional study plasma concentrations of the major calcium-regulating hormones--namely, calcitonin, parathyroid hormone, 25-hydroxyvitamin D (25-OHD), and 1,25-dihydroxyvitamin D (1,25-(OH)2D)--were measured to establish their interrelations during normal pregnancy. The major changes observed were increases in the circulating concentrations of 1,25-(OH)2D and calcitonin. Concentrations of parathyroid hormone and 25-OHD remained within the normal range. The increased concentrations of 1,25-(OH)2D enable the increased physiological need for calcium to be met by enhancing intestinal absorption of this element. The simultaneous rise in calcitonin opposes the bone-resorbing activities of 1,25-(OH)2D, thereby protecting the integrity of the maternal skeleton. Maternal calcium homeostasis is thus maintained yet the requirements of the fetus are fulfilled.
FUNDAMENTAL DIFFICULTIES IN THE TREATMENT OF PEPTIC ULCER
Authors: WALTER LINCOLN PALMER
Journal: JAMA (1933)

The two chief problems of ulcer therapy are, first, to promote healing of the lesion present and, second, to prevent its recurrence. My purpose in this paper is to emphasize the fact that the fundamental difficulty in accomplishing both of these ends is that of satisfactorily combating the digestive action of the gastric juice over adequate periods of time.  It has been known for years that acid gastric juice is able to kill and digest living tissue. In 1859, Claude Bernard showed that the leg of a living frog is digested when introduced through a fistula into the stomach of a dog. This work has been repeated and extended recently by Dragstedt and his co-workers. 1 It has been found that the concentration of pepsin is of relatively little importance compared with the concentration of acid, that digestion occurs with acid concentrations above 0.1 per cent and that the rate
Failure to inform public is undermining confidence in clinical trials
Authors: C. Marwick
Journal: BMJ (2002)

Failure to fully inform the public about the involvement of participants in clinical trials is undermining confidence in the process–and in turn leading to a reduction in the number of studies involving humans.

That was the message from Dr Philip Noguchi, director of the Division of Cellular and Gene Therapies at the Food and Drug Administration, speaking at a recent meeting of the Regulatory Affairs Professional Society in Washington, DC. The credibility of clinical research in this country has been severely damaged,” he said.

The immediate trigger of the concern has been the conduct of gene therapy studies. “Of all the fields that the FDA regulates, gene therapy is the one which is in the public eye,” Dr Noguchi said. But the situation involves all clinical research.

He cited one widely publicised event, the death in 1999 …
Acute thrombocytopenic purpura in an infant with cushing's syndrome: A case report
Authors: Gady M. Magbool
Journal: American Journal of Hematology (1993)

Abstract This paper describes the case of a female child who presented with severe thrombocytopenia and Cushing's syndrome. The underlying cause was found to be an adrenal cortical adenoma, removal of which was followed by complete recovery of both conditions. The pathogenesis of both presenting features in relation to the adrenal tumor is discussed.
Targeting portal pressure measurements: A critical reappraisal
Authors: Ulrich Thalheimer, Maria Mela, David Patch, Andrew K. Burroughs
Journal: Hepatology (2004)

Many of the complications of cirrhosis reflect the presence of portal hypertension, which is commonly expressed as the hepatic venous pressure gradient (HVPG). Baseline and repeat measurements of HVPG have been recommended for the management of patients with cirrhosis in the setting of pharmacologic prophylaxis of variceal bleeding and for gaining information about prognosis. However, published studies have demonstrated problems with the interpretation of the data on HVPG monitoring, making its use controversial. We view the current data as insufficient evidence to support the monitoring of a targeted reduction of HVPG as routine clinical practice. We recommend the performance of new prospective studies to establish the clinical importance of HVPG measurements.
Risk of coronary heart disease (CHD) between sports persons and sedentary persons
Authors: Rabindra Kumar, Sunil Purohit, Sandeep Kumar
Journal: British Journal of Sports Medicine (2010)

The purpose of the current study was to know the effect of exercise on coronary heart disease (CHD) between sports persons and sedentary persons. We performed a randomised trial to compare the CHD between sports and sedentary persons. Ten sports persons were compared with 10 sedentary persons. Subjects were assessed for serum total cholesterol, triglycerides (TG), high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C), very low density lipoprotein (VLDL-C) and C/H-ratio, which are indicators of CHD. Results showed lower levels of TG and VLDL-C but high level of HDL-C (good cholesterol) values (p&lt;0.05) in sports persons as compared to sedentary persons. Results also indicated that total cholesterol mean value of sports persons was lower compared to sedentary persons. Sports persons are at lower risk of development and progression of CHD as compared to sedentary persons, indicating that exercise will help to maintain their lipid profile, which plays a key role in CHD and atherosclerosis. Studies clearly show that sports persons are less likely to develop CHD than sedentary persons. Thus routine exercise is recommended for all sedentary persons in their busy schedules for a good healthy life.
Pityriasis rotunda in Tanzania
Authors: S. Gibbs
Journal: British Journal of Dermatology (1996)

Journal Article Pityriasis rotunda in Tanzania Get access S. Gibbs S. Gibbs Department of Dermatology, West Norwich Hospital, Norwich NR2 3TU, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 135, Issue 3, 1 September 1996, Pages 491–492, https://doi.org/10.1111/j.1365-2133.1996.tb01528.x Published: 01 September 1996
Sunday Morning Call
Authors: Peter Gruen
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Physicians and Joint Negotiations
Authors: Johnathon S. Ross
Journal: Annals of Internal Medicine (2002)

Letters7 May 2002Physicians and Joint NegotiationsJohnathon S. Ross, MDJohnathon S. Ross, MDPhysicians for a National Health ProgramToledo, OH 43606Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-136-9-200205070-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The ACP–ASIM position paper on joint negotiations (1) fails to address a key question: Who should be the negotiator for our patients? The critical relationship is between patients and physicians. Physicians should negotiate with patients, not with insurers. Of course, we cannot negotiate our fees one patient at a time. Health care has changed. The community must share the costs of medical care to make new, beneficial technologies affordable; hence the need for an insurance mechanism. For-profit insurance corporations have taken on part of this community role, but their legal and fiduciary duty is not to patients ...Reference1. . Physicians joint negotiations. American College of Physicians–American Society of Internal Medicine. Ann Intern Med. 2001;134 9 Pt 1 Pt 1 787-92. [PMID: 11329239] MedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Johnathon S. Ross, MDAffiliations: Physicians for a National Health ProgramToledo, OH 43606 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoPhysicians and Joint NegotiationsAmerican College of Physicians–American Society of Internal Medicine*Physicians and Joint NegotiationsAmerican College of Physicians–American Society of Internal Medicine*Physicians and Joint Negotiations Jack Ginsburg Physicians and Joint Negotiations Allan R. Glass Physicians and Joint Negotiations Gary H. Oberlender Metrics 7 May 2002Volume 136, Issue 9Page: 710KeywordsHealth careHealth insuranceNatural history of diseasePatient advocacy ePublished: 7 May 2002 Issue Published: 7 May 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Hospital-Physician Relationships: Case Studies and Commentaries on Medical Staff Problems
Authors: George Ross Fisher
Journal: JAMA (1983)

Relations between the medical and legal professions are so strained by malpractice litigation that it often goes unnoticed that most mainstream lawyers do not belong to, indeed may even harbor reservations about, the trial bar. Consequently, we may inadequately acknowledge the legal profession as a useful and honorable one, with much to teach us about the handling of our affairs. The goal of his book, although Nathan Hershey states it somewhat differently, is to dramatize the range of awkward situations that plausibly could arise in any hospital and that should, therefore, be anticipated in the drafting of any hospital's medical staff bylaws. The medical staff, writing its bylaws, resembles the man writing his will, who must be diplomatically persuaded to include "boilerplate" provision against eventualities he refuses to take seriously but that do, nevertheless, litter the landscape of human affairs. In this book, a series of fictionalized episodes parade before
The role of trauma in the spreading weals of hereditary angio-oedema
Authors: R.P. WARIN
Journal: British Journal of Dermatology (1983)

Twenty patients with hereditary angio-oedema (HAO) were regularly observed. Trauma often initiates the swellings of HAO which, once formed, may continue to spread. In the prodromal rash too, a narrow band of weals spreads out from a central point, which often corresponds to a site of trauma e.g. a pin prick. The relationship of these observations to the role of trauma in the initiation and spread of weals in other forms of urticaria is discussed.
The long and winding road leading to the identification of the hepatitis C virus
Authors: Michael Houghton
Journal: Journal of Hepatology (2009)

This review describes work conducted largely in my laboratory at the Chiron Corporation between 1982 and 1989 that led to the identification of the hepatitis C virus (HCV). Key colleagues included Dr. Qui-Lim Choo in my laboratory and Dr. George Kuo also of Chiron as well as my collaborator Dr. Daniel Bradley at the CDC who provided many biological samples from the NANBH chimpanzee model. Numerous molecular approaches were explored including the screening of tens of millions of bacterial cDNA clones derived from these materials. While this early genomics approach resulted in the identification of many host gene activities associated with NANBH, no genes of proven infectious etiology could be identified. A separate avenue of our research led to the molecular characterization of the complete hepatitis delta viral genome but unfortunately, this could not be used as a molecular handle for HCV. Largely following input from Dr. Kuo, I initiated a blind cDNA immunoscreening approach involving the large-scale screening of bacterial proteomic cDNA libraries derived from NANBH-infectious chimpanzee materials (prior to the development of PCR technology) using sera from NANBH patients as a presumptive source of viral antibodies. Eventually, this novel approach to identifying agents of infectious etiology led to the isolation of a single small cDNA clone that was proven to be derived from the HCV genome using various molecular and serological criteria. This discovery has facilitated the development of effective diagnostics, blood screening tests and the elucidation of promising drug and vaccine targets to control this global pathogen.
Endoscopic Polypectomy in the Upper Gastrointestinal Tract
Authors: M. Singer, R. Busse, H. Seib, K. Elster, R. Ottenjann
Journal: Endoscopy (1975)

Endoscopic polypectomy has brought a pragmatic solution to the problems associated with the frequent occurrence of polyps in the upper gastrointestinal tract. In 276 polypectomies performed in 181 patients, complications were observed in only 1.4%. Neither perforation nor lethal complication was observed. Comparison between histological examination of the biopsy specimens obtained prior to polypectomy and the histological findings in the polyps removed in toto showed differing pattern in 54 of 120 gastric polyps. This was due to the fact that mixed forms of polyps and mesenchymal tumours are not established with the forceps biopsy. 3.3% of all the polyps removed were malignant. Patients with hyperplasiogenic gastric polyps seem to have an increased cancer risk. Gastroscopic screening examinations carried out every 6 month are therefore recommended in these patients.
The Pathology and Treatment of Sun-Stroke
Authors: George Johnson
Journal: BMJ (1868)

August T, z88 Four weeks after the aopertion, the wound being completely cicatrised, she waS allowed to move about in her rom; and, just six weeks from the date of the ligature of the artery, she descended three long flights of stairs, walked for some time in the strcets, and reascended t e steps to her lodgings; and, though fatigued by the effort, she felt next day all the better Tor it.On March 3ist, she called to see me, much improved in strength, though with still some tendency to swelling of the legs, especially the left, when in the erect posture.The aneurismal swelling felt merely like a slight glandular thickening.[On July 25th, i868, I again visited her.She had derived much benefit from a stay at the sea- side, and the tendency to cedema of the extremities was greatly dimi- nished.There was still absence of pulsation in the external iliac artery, and the cicatrix remained quite sound twenty-five weeks after the opera- tion; so that, whatever may have become of the ligture, there need be no apprehension of its ever making its appearance externally.]The success of these cases of ligature depends, as we have seen, upon the circumstance that not only a neutral foreign body, but a portion of dead tissue, if simply protected from putrefaction, is entirely devoid of irritating properties.A good example of this fact is presented by a
Pulmonary Edema Fluid from Patients with Acute Lung Injury Augments <i>In Vitro</i> Alveolar Epithelial Repair by an IL-1 β -dependent Mechanism
Authors: THOMAS GEISER, KAMRAN ATABAI, PIERRE-HENRI JARREAU, LORRAINE B. WARE, JÉRÔME PUGIN, MICHAEL A. MATTHAY
Journal: American Journal of Respiratory and Critical Care Medicine (2001)

Efficient alveolar epithelial repair is crucial for the restoration of the injured alveolar epithelial barrier in patients with acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS). We hypothesized that pulmonary edema fluid from patients with ALI / ARDS would inhibit alveolar epithelial repair as measured in an in vitro epithelial wound-repair model using the human alveolar epithelial-like cell line A549. In contrast to our initial hypothesis, pulmonary edema fluid from patients with ALI / ARDS increased alveolar epithelial repair by 33 ± 3% compared with pooled plasma from healthy donors (p < 0.01). By contrast, the plasma and the pulmonary edema fluid from patients with hydrostatic pulmonary edema, and the plasma from patients with ALI / ARDS had similar effects on epithelial repair as pooled plasma from healthy donors. Inhibition of interleukin-1 β (IL-1 β ) activity by IL-1 receptor antagonist reduced alveolar epithelial repair induced by ALI / ARDS edema fluid by 46 ± 4% (p < 0.001), indicating that IL-1 β contributed significantly to the increased epithelial repair. In summary, pulmonary edema fluid collected early in the course of ALI / ARDS increased alveolar epithelial repair in vitro by an IL-1 β -dependent mechanism. These data demonstrate a novel role for IL-1 β in patients with ALI / ARDS, indicating that IL-1 β may promote repair of the injured alveolar epithelium.
Genetic Dissection of the Oncogenic mTOR Pathway Reveals Druggable Addiction to Translational Control via 4EBP-eIF4E
Authors: Andrew C. Hsieh, Maria Costa, Ornella Zollo, Cole Davis, Morris E. Feldman, Joseph R. Testa, Oded Meyuhas, Kevan M. Shokat, Davide Ruggero
Journal: Cancer Cell (2010)
A SIMPLE METHOD OF CYSTOSCOPY.
Authors: M. C. MILLET
Journal: JAMA (1904)

Specialists, and a gradually increasing number of the profession, regard cystoscopy as a diagnostic measure of merit. A multiplicity of instruments and variety of technic have contributed not a little to a feeling of distrust and reluctance to accept it by the profession at large. Of the many kinds of cystoscopes most of them have been devised or modified by the pioneers in genito-urinary diagnosis. In the hands of its originator probably each instrument is a success, but in the hands of a stranger many are more or less of a failure. Water dilatation of the bladder seems the rational method. The difficulty or impossibility of examining an occasional bladder, from blood or pus clouding the inflating fluid, led to the devising of instruments to be used with air dilatation. Air in the bladder is a foreign body and by the conscious patient is treated as such. Frequent sponging to remove urine or blood is provocative of further hemorrhage and increases the difficulties.
Global commissioning by GPs could be detrimental to rehabilitation services
Authors: J. Charlton, R. Morton, C. Murray-Leslie, C. Ward
Journal: BMJ (1996)

birth.For most women, probably, even a small excess risk of death would be reason enough to avoid the possibility of being the "extra" one to suffer a perinatal loss.At present, the advice available to women is hampered by the lack of sufficient good quality evidence.
Hematopoietic Expression of Hoxb4 Is Regulated in Normal and Leukemic Stem Cells through Transcriptional Activation of the Hoxb4 Promoter by Upstream Stimulating Factor (Usf)-1 and Usf-2
Authors: Diane M. Giannola, Warren D. Shlomchik, Mithila Jegathesan, David Liebowitz, Charles S. Abrams, Tom Kadesch, Andrew Dancis, Stephen G. Emerson
Journal: The Journal of Experimental Medicine (2000)

The homeobox genes encode a family of transcription factors that regulate development and postnatal tissue homeostasis. Since HOXB4 plays a key role in regulating the balance between hematopoietic stem cell renewal and differentiation, we studied the molecular regulation of HOXB4 expression in human hematopoietic stem cells. HOXB4 expression in K562 cells is regulated at the level of transcription, and transient transfection defines primary HOXB4 regulatory sequences within a 99-bp 5' promoter. Culture of highly purified human CD34(+) bone marrow cells in thrombopoietin/Flt-3 ligand/stem cell factor induced HOXB4 3-10-fold, whereas culture in granulocyte/macrophage colony-stimulating factor, only increased HOXB4/luciferase expression 20-50%. Mutations within the HOXB4 promoter identified a potential E box binding site (HOX response element [HXRE]-2) as the most critical regulatory sequence, and yeast one hybrid assays evaluating bone marrow and K562 libraries for HXRE-2 interaction identified upstream stimulating factor (USF)-2 and micropthalmia transcription factor (MITF). Electrophoretic mobility shift assay with K562 extracts confirmed that these proteins, along with USF-1, bind to the HOXB4 promoter in vitro. Cotransfection assays in both K562 and CD34(+) cells showed that USF-1 and USF-2, but not MITF, induce the HOXB4 promoter in response to signals stimulating stem cell self-renewal, through activation of the mitogen-activated protein kinase pathway. Thus hematopoietic expression of the human HOXB4 gene is regulated by the binding of USF-1 and USF-2, and this process may be favored by cytokines promoting stem cell self-renewal versus differentiation.