tbuckley/cabot-search huggingface dataset:
Induction of Corticosteroid ResistanceIn Vitro
Authors: Donald Y. M. Leung, Joseph D. Spahn, Sai R. Nimmagadda, Stanley J. Szefler
Journal: American Journal of Respiratory and Critical Care Medicine (1996)

"Induction of Corticosteroid Resistance In Vitro." American Journal of Respiratory and Critical Care Medicine, 154(2_pt_2), pp. S34–S38
A Surgeon's Odyssey
Authors: Charles B. Wilson
Journal: JAMA (1974)

In this book the author, an eminent surgeon who became a legendary figure at Northwestern Medical School, tells his life's story, beginning as the son of a railroad engineer in Galesburg, Ill, and ending with his retirement. Although sprinkled liberally with personal anecdotes, the book offers a clear view of the author's attitudes in medical curricula, clinical teachers, and fee-splitting. Davis favored preceptorial teaching for residents. Repeatedly he defends the unpaid clinical faculty, maintaining that remuneration from a medical school does not enhance the value of a teacher. He attributes the erosion of mutual regard between clinical and preclinical teachers to jealousy over financial incomes, academic ranks, and domination of curriculum. After becoming Chairman of Surgery he abolished lectures to medical students. He first encountered competitive fee-splitting as a general surgeon and thereafter fearlessly opposed it. Ultimately the Chicago Medical Society brought charges against him for statements quoted by the
Pharicin B stabilizes retinoic acid receptor-α and presents synergistic differentiation induction with ATRA in myeloid leukemic cells
Authors: Zhi-Min Gu, Ying-Li Wu, Mei-Yi Zhou, Chuan-Xu Liu, Han-Zhang Xu, Hua Yan, Yong Zhao, Ying Huang, Han-Dong Sun, Guo-Qiang Chen
Journal: Blood (2010)
Ischemic Preconditioning Decreases Apoptosis in Rat Hearts In Vivo
Authors: Christophe A. Piot, Devi Padmanaban, Philip C. Ursell, Richard E. Sievers, Christopher L. Wolfe
Journal: Circulation (1997)

Previous studies have demonstrated that ischemic preconditioning prevents lethal cell injury and, as a consequence, limits infarct size in rat heart. Although both apoptosis and necrosis have been shown to contribute to myocardial cell death after myocardial ischemia and reperfusion, the ability of ischemic preconditioning to prevent programmed cell death remains unknown.To test the hypothesis that ischemic preconditioning reduces irreversible ischemic injury in part by decreasing apoptosis, rats that underwent ischemic preconditioning and controls were subjected to 30 minutes of left coronary artery occlusion followed by 180 minutes of reperfusion. Ischemic preconditioning was achieved by five 5-minute cycles of ischemia, each followed by 5 minutes of reperfusion. Infarct size, determined by dual staining with triphenyltetrazolium chloride and phthalocyanine blue dye, was significantly reduced in preconditioned compared with nonpreconditioned rats (11.4+/-1.4% versus 58.7+/-1.4%; n=20 in each group; P<.001; infarct size/risk area). Genomic DNA from preconditioned hearts showed little or no oligonucleosome-sized fragments (200-bp multiples), whereas genomic DNA from nonpreconditioned hearts showed a typical nucleosome fragmentation. The TUNEL assay localized fewer and sparsely stained nuclei within the infarct zone of ischemic preconditioned hearts compared with nonpreconditioned hearts. Consistent with these findings, the number of cytosolic histone-associated low-molecular-weight DNA fragments was significantly decreased in preconditioned hearts compared with controls (0.17+/-0.02 versus 1.07+/-0.09 U; n=10 in each group; P<.001; absorbance 405 nm/490 nm).This study suggests that ischemic preconditioning reduces irreversible ischemic injury in part by decreasing apoptosis after prolonged ischemia and reperfusion.
Global exhibition will highlight drug resistant TB
Authors: P. Moszynski
Journal: BMJ (2008)

An international multimedia campaign is being launched this week to draw attention to the growing problem of drug resistant tuberculosis.

Centred on the work of the Pulitzer prize winning photojournalist James Nachtwey, and funded by an award from the annual “Technology, Entertainment, Design” conference (www.ted.com), the campaign is being launched simultaneously on 3 October in public spaces on seven continents, from Times Square in New York to Antarctica. In London the pictures are being projected onto the flytower of the National Theatre and also feature in a static exhibition, entitled The Emergency Room, in Bethnal Green, east London.



Mr …
The Presence of Retinopathy in Patients with Secondary Diabetes Following Pancreatectomy or Chronic Pancreatitis
Authors: Antonio Tiengo, Tatiana Segato, Giustina Briani, Antonio Setti, Stefano Del Prato, Antonio Devidé, Domenico Padovan, Flavio Virgili, Gaetano Crepaldi
Journal: Diabetes Care (1983)

The incidence of diabetic retinopathy was evaluated by means of fluorescein angiography in 54 patients with diabetes secondary to chronic pancreatitis or to pancreatectomy. Thirty-one percent of the patients had background retinopathy; none had proliferative retinopathy. The percentage of patients with retinopathy was the same in groups with or without a family history of diabetes. There was no correlation between the degree of metabolic control, the levels of C-peptide, glucagon, growth hormone, and the presence of retinopathy. Retinopathy was correlated with the duration of diabetes. In conclusion, diabetes caused by pancreatitis or pancreatectomy has a significant prevalence of retinopathy, which has more benign characteristics and slower evolution than the retinopathy in patients with primary diabetes.
Articulating a Social Ethic for Health Care
Authors: Richard A. Epstein
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Determinants of undiagnosed asthma
Authors: L. Nathell, K. Larsson, I. Jensen
Journal: Allergy (2002)

The conformity between asthma diagnosed in a clinical setting and asthma from an epidemiological point of view has not been much studied.History, symptoms, and clinical findings in persons with and without a previous physician diagnosed asthma were studied among persons classified as having asthma according to an epidemiological definition.Smoking was more prevalent in persons not diagnosed as having asthma prior to the study (n = 96), than in those with a previous asthma diagnosis (n = 119), (60% vs. 41%, P = 0.006). Positive skin prick test (SPT) was less common (39.6% vs. 58.0%, P = 0.009), lung function expressed as FEV1.0 in percentage of predicted was better (92.1 vs. 85.4, P = 0.018), reversibility to a bronchodilator was smaller (mean reversibility 4.0% vs. 6.2% of predicted, P = 0.003) and symptoms were less frequently reported (P < 0.001) by those who had not a physician diagnosed asthma prior to the study.The asthma diagnosis is often overlooked by the medical profession in patients with mild disease. Furthermore, smoking seems to worsen asthma exacerbations in patients with mild disease.
Surface modifications in the platelets of a patient with alpha-N-acetyl-D-galactosamine residues, the Tn-syndrome.
Authors: A T Nurden, D Dupuis, D Pidard, N Kieffer, T J Kunicki, J P Cartron
Journal: Journal of Clinical Investigation (1982)

The Tn-syndrome is an acquired disorder characterized by the polyagglutination of blood cells and the pathological exposure of alpha-N-acetyl-D-galactosamine residues (Tn-antigen) at the cell surface. We now report studies on the platelet of a patient (Ba.) of which 81% reacted positively with a fluorescein conjugate of Helix pomatia agglutinin (HPA). The surface proteins of Ba. platelets were labeled with 125I by the lactoperoxidase-catalyzed procedure; single and two-dimensional electrophoresis on sodium dodecyl sulfate (SDS)-polyacrylamide gels was followed by autoradiography that revealed normal 125I-labeling of the major membrane glycoproteins (GP) but that GP Ib had a faster than normal migration. the abnormal GP Ib of Ba. platelets was strongly labeled when platelet suspensions were treated sequentially with neuraminidase, galactose oxidase, and sodium [3H]borohydride. Unlike the GP Ib of normal human platelets, it was also strongly labeled when Ba. platelets were treated with galactose oxidase and sodium [3H]borohydride alone. Both the alloantigen, PlA1, and quinidine-dependent antibody receptor activity were normally expressed by Ba. platelets, which also bound a monoclonal antibody (AN51) to GP Ib. Analysis of Ba. platelets by crossed immunoelectrophoresis using a rabbit anti-human platelet antibody preparation revealed the presence of an immunoprecipitate in the GP Ib position that had an abnormal appearance and migration in the second dimension. An altered position of the precipitate given by Factor VIIIR:Ag was also noted. Incorporation of HPA into the agarose gel during the first dimension electrophoresis resulted in the specific precipitation of the abnormal GP Ib of Ba. platelets. Our studies show that circulating Tn-platelets contain GP Ib with a modified oligosaccharide chain structure responsible for the platelet expression of Tn-antigen activity.
Diagnosing Alzheimer's disease.
Authors: R. E. Butler, D. C. Costa, P. J. Ell, C. L. Katona, A. Creco
Journal: BMJ (1992)

ground.2Damage to the mitral valve may occur when the heart is violently compressed at the end ofdiastole, when the left ventricle is full.'This may cause rupture of the chordae tendineae or papillary muscles or damage to the valve leaflets themselves.4In severe cases symptoms may occur directly after the injury, but in some cases they may be delayed for several years.'Our patient's posterior mitral valve prolapse was probably due to damage to the chordae tendineae sustained during the crush at the football ground.Such cases have medicolegal implications as mitral valve surgery may become necessary.
Report of Two Cases of Precocious Puberty
Authors: J. Davidson
Journal: BMJ (1958)

HETEROTOPIC SQUAMOUS-CELL CARCINOMAS Botw 1219They also proposed that alcohol consumption acted as a promoter of carcinoma of the larynx.It is reasonable to suppose that multiple primary tumours will occur with increasing frequency as the survival rate for cancer continues to improve with advances in diagnostic and therapeutic techniques.In this patient, for example, a com- plete cure of her skin and laryngeal carcinomas was effected by radiotherapy. SummaryThe case history is described of a woman who died at the age of 71 of a squamous-cell carcinoma of the bronchus after the successful treatment of two other squamous-cell carcinomas, on the face and on a vocal cord, in the last 10 years of her life.From a review of the literature evidence is presented that suggests there was a systematic predisposition to cancer in this patient.We acknowledge with thanks the interest and advice of Sir Daniel Davies.The patient had also been under the care of Miss G. Barry, Miss P. Wade, and
Supravalvular Aortic Stenosis: Clinical Experiences with Ten Patients Including Occurrences in Two Families.
Authors: C. F. Wooley
Journal: Annals of Internal Medicine (1963)

s1 April 1963Supravalvular Aortic Stenosis: Clinical Experiences with Ten Patients Including Occurrences in Two Families.C. F. Wooley, M.D., C. V. Meckstroth, M.D., H. Sirak, M.D., D. M. Hosier, M.D., W. Molnar, M.D.C. F. Wooley, M.D.Search for more papers by this author, C. V. Meckstroth, M.D.Search for more papers by this author, H. Sirak, M.D.Search for more papers by this author, D. M. Hosier, M.D.Search for more papers by this author, W. Molnar, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-4-714_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptClinical recognition of supravalvular aortic stenosis causing left ventricular outflow obstruction is a recent event. Initially considered to be a pathologic curiosity, it is now apparent that supravalvular aortic stenosis is relatively common in patients with obstruction to left ventricular outflow.Clinical experiences with 10 patients during a 2-year interval are presented. There were 7 males and 3 females, the youngest being 3½ years and the oldest 49 years. Two instances of familial occurrence include a mother and son in one family and a brother and sister in another.Clinical findings included an aortic systolic ejection murmur, absence of an... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Columbus, Ohio (CS) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1963Volume 58, Issue 4Page: 714-714KeywordsStenosisSystolic ejection murmur Issue Published: 1 April 1963 PDF DownloadLoading ...
Surgical intervention for capsule endoscope retained at ileal stricture
Authors: Y. Bai, J. Gao, B. Song, Y. Zhou, D. Zou, Z. Li
Journal: Endoscopy (2007)

Capsule endoscopy is an invaluable, safe examination for the small bowel [1]. We report a case of operation for a capsule endoscope retained at an ileal stricture in a patient with multiple ileal strictures.
Maple-Bark Disease
Authors: Dean A. Emanuel, Ben R. Lawton, Frederick J. Wenzel
Journal: New England Journal of Medicine (1962)

THE clinical impression that some types of pneumonitis may be caused by individual hypersensitivity to molds or their products has received increasing attention in recent years.1 , 2 The exact role of molds, dust and individual susceptibility, however, is not fully understood. "Farmer's lung" is thought to be caused by a reaction of this type, but bagassosis and "mushroom-grower's disease" may also be related to such a phenomenon.In the following case of pneumonitis we were able to demonstrate a rare and unusual mold to be the causative agent.Case ReportA 20-year-old man was first seen in March, 1961, complaining of . . .
Management of Azotemic Osteodystrophy.
Authors: J. H. Felts
Journal: Annals of Internal Medicine (1964)

s1 April 1964Management of Azotemic Osteodystrophy.J. H. Felts, M.D., F.A.C.P., H. H. Bradshaw, M.D., D. D. Anderson, M.D., J. E. Whitley, M.D.J. H. Felts, M.D., F.A.C.P.Search for more papers by this author, H. H. Bradshaw, M.D.Search for more papers by this author, D. D. Anderson, M.D.Search for more papers by this author, J. E. Whitley, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-4-737_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAzotemic osteodystrophy results from secondary hyperparathyroidism and is manifested by typical bony changes, an elevated alkaline phosphatase and, often, a high normal serum calcium concentration. With progression, bone pain and spontaneous fractures lead to skeletal deformity and invalidism. Treatment with oral alkali is ineffective but vitamin D in oral doses to 200,000 units daily usually relieves symptoms within 6 weeks and induces recalcification of bone. Hypervitaminosis D becomes a constant threat to renal function during therapy but skeletal symptoms recur quickly when calciferol is discontinued.In November, 1960, a 38-year-old woman with azotemia, elevated serum alkaline phosphatase and radiographically classical... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Winston-Salem, North Carolina PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1964Volume 60, Issue 4Page: 737-737KeywordsAttentionBoneCalciumHyperparathyroidismPhosphatasesVitamin D ePublished: 1 December 2008 Issue Published: 1 April 1964 PDF downloadLoading ...
"Early, curable stage" of rheumatoid arthritis.
Authors: F. Bach
Journal: BMJ (1965)

present at the interview, were of the opinion that the child could hear and understand very simple sentences.She was said to have diffi- culty in expressing herself, owing to her Turkish-speaking background.Her intelligence and emotional stability were said to be at least average, and her adjustment at school appeared very satisfactory.Auriscopy showed the left drum to be normal, and the right drum retracted.Calling the child by name, with her eyes closed, or while standing behind her, on either side, produced the impression that she did not respond to or localize sounds in either ear.Some days later the headmistress mentioned that on a previous day she had repeatedly called after the child, who was going home from school, and the child had remained unaware of her.This was the first time that any member of the teaching staff had suspected deafness during the six months in which the child was at school.The mother later attended for interview, and was accompanied by an English-speaking Turkish Cypriot friend.Deafness was said to have been first suspected by both parents at the age of 4 years, when there was no progress in speech development.It was said that the child's speech, even in Turkish, was very restricted.The child was later tested at a special audio- logy unit and it was clear from the audiogram that she had a high frequency loss of hearing, with a fairly severe superimposed conductive loss.The child was recommended for a school for deaf children, and some months later was seen to be using headphones, with an amplifier, for school lessons, and was using hearing-aids at other times.She had fitted in well at the school and was making some progress despite the language difficulty.
A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1
Authors: Yongyong Shi, Zhibin Hu, Chen Wu, Juncheng Dai, Huizhang Li, Jing Dong, Meilin Wang, Xiaoping Miao, Yifeng Zhou, Feng Lu, Hanze Zhang, Lingmin Hu, Yue Jiang, Zhiqiang Li, Minjie Chu, Hongxia Ma, Jiaping Chen, Guangfu Jin, Wen Tan, Tangchun Wu, Zhengdong Zhang, Dongxin Lin, Hongbing Shen
Journal: Nature Genetics (2011)
Clinical Evaluation of Cyclophosphamide
Authors: Donald J. Fernbach
Journal: JAMA (1962)

Forty-four children with advanced acute leukemia were treated with cyclophosphamide (Cytoxan ). Complete remissions were observed in 8 and partial remissions in 5. The complete remissions were independent of antecedent or concomitant steroid therapy and persisted from 3 to 15 months. Three of these patients developed leukemic involvement of the central nervous system, though otherwise in complete remission, indicating that cyclophosphamide did not inhibit this complication. The previous favorable response of the patients achieving complete remission to the steroids 6-mercaptopurine and methotrexate ( Amethopterin) eliminated the possibility of any cross-resistance between these agents and cyclophosphamide. The most common side effect was leukopenia which was readily reversible by interruption of therapy. Hemorrhagic cystitis, alopecia, hepatitis, anorexia, diarrhea, nausea, vomiting, and dizziness were other reported side reactions. Cyclophosphamide appears to be an important addition to the chemotherapy of children with acute leukemia.
Type 2 Diabetes Mellitus in Children
Authors: David S. Ludwig, Cara B. Ebbeling
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Antigen-induced human T cell help. Precursor frequency, radiation sensitivity, and allogeneic effects.
Authors: H C Lane, G Whalen, A S Fauci
Journal: Journal of Clinical Investigation (1983)

We have recently noted marked differences between the in vitro responses of human B lymphocytes to stimulation with soluble antigens vs. stimulation with mitogens. In the present study, these differences were analyzed in terms of the precursor frequencies for the T cells and B cells involved and in terms of the radiation sensitivity of the T cells providing help in the two systems. Marked differences were found between antigen-induced and mitogen-induced systems with regard to T cell precursor frequencies and radiation sensitivity. In contrast, the precursor frequencies for the B cells involved in the two systems were approximately the same. In addition, having developed a system for the study of human antigen-specific B cell responses, we were interested in delineating the nature of the allogeneic effects that might be operative in this system. Marked allogeneic effects, both positive and negative, were noted in this system and will need to be taken into account in any studies that try to address the question of the genetic restriction, if any, that exists in human antigen-specific T cell-B cell collaboration. Appreciation of the marked differences between the antigen-specific and mitogen-induced activation and immunoregulation of human B cell responses will be of importance in understanding the relationship between specificity and nonspecificity of antibody production in normal and disease states.
Failure of Iron-Deficient Infants to Respond to an Orally Administered Iron-Carbohydrate Complex
Authors: Jean D. Ross
Journal: New England Journal of Medicine (1963)

ALTHOUGH many hematinics are available ferrous sulfate remains the drug of choice for the treatment of iron-deficiency anemia.1 , 2 Its therapeutic effect is prompt and reliable, and its cost is extremely low. It has been claimed that it is relatively unpalatable in the liquid form and may, therefore, be refused by the iron-deficient infant although it has been my experience that most infants take ferrous sulfate without difficulty.An ideal iron preparation for infants and children would combine the therapeutic effectiveness of ferrous sulfate with a pleasant flavor. Recently, a preparation has become available to the practicing physician in the form . . .