tbuckley/cabot-search huggingface dataset:
Circulation of Cerebrospinal Fluid
Authors: G. Steiner
Journal: BMJ (1964)

abnormality noted on examination.The haemo- globin value was 12.6 g./ 100 ml., with marked anisocytosis and many nucleated erythrocytes, spherocytes, and aberrant forms in a smear of peripheral blood.Of the erythrocytes approximately 40% were reticulocytes, and approxi- mately 80% contained Heinz bodies.The total serum bilirubin content was 5.3 mg./ 100 ml. and the conjugated serum bilirubin content 0.4 mg./100 ml.The mother's blood group was 0, Rh negative and the infant's blood group 0, Rh positive.The direct Coombs test was negative.The glucose-6-phosphate dehydrogen- ase (G6PD) activity by the method of Zinkham' was 260 units 100 ml. of erythrocytes.After transfusion of 100 ml. of blood the in- fant's condition improved rapidly.On 23 December the child was free of jaundice and purpura, the haemoglobin level was 23 g./100 ml., the erythrocytes were of normal appearance, and thrombocytes were present in normal numbers.The child has progressed well until the present time, with haemoglobin levels and thrombocyte counts within the normal range.Both parents are of Anglo-Saxon racial ex- traction.Over the last three weeks of pregnancy the mother had suffered from urinary symptoms and some oedema.For 15 days before delivery she had received sulphamethizole, 0.5 g. every four hours, and chlorothiazide, 0.5 g. daily.Case 2.-This female infant was first seen on 29 July 1963 at the age of 4 days, with a history of slowly increasing jaundice from the age of 24 hours.The infant was believed to be three weeks premature, but the birth weight was 3.6 kg.Gross jaundice was the only abnormality on physical examination.The total serum bilirubin content was 16.5 mg./100 ml., and the conju- gated serum bilirubin content less than 0.5 mg./ 100 ml.The haemoglobin level was 19.0 g./100 ml., reticulocytes comprised about 3 % of the erythrocytes, and Heinz bodies were present in approximately 20% of the erythrocytes.No
THE MULTIPLICATION OF THE VIRUS OF YELLOW FEVER IN AËDES AEGYPTI
Authors: Loring Whitman
Journal: The Journal of Experimental Medicine (1937)

Aëdes aegypti have been shown to be capable of multiplying the Asibi strain of yellow fever virus in their bodies. Following the ingestion of infected blood, the content of virus falls for several days, reaching a minimum during the 1st week. It then increases rapidly until quantities of virus greater than those previously encountered can be demonstrated. The actual final amount of virus demonstrable, however, is subject to variations of which we know little.
Can Expedited FDA Drug Approval Without Expedited Follow-up Be Trusted?
Authors: Daniel Carpenter
Journal: JAMA Internal Medicine (2013)

6. 21 USC §355–1. Risk evaluation andmitigation strategies. www.gpo.gov/fdsys/pkg/USCODE-2012 -title21/pdf/USCODE-2012-title21-chap9 -subchapV-partA-sec355-1.pdf. Accessed September 20, 2013. 7. President’s Council of Advisors on Science and Technology. Report to the President on Propelling Innovation in Drug Discovery, Development and Evaluation. Washington, DC: Executive Office of the President of the United States; September 1, 2012.
Road safety in Africa
Authors: Meleckidzedeck Khayesi, Margie Peden
Journal: BMJ (2005)

<h3>Background</h3> Chest X-rays (CXRs) are traditionally obtained daily in all patients on invasive mechanical ventilation (IMV) in the intensive care unit (ICU). We sought to reduce overutilisation of CXRs obtained in the ICU, using a multifaceted intervention to eliminate automated daily studies. <h3>Methods</h3> We first educated ICU staff about the low diagnostic yield of automated daily CXRs, then removed the 'daily' option from the electronic health records-based ordering system, and added a query (CXR indicated or not indicated) to the ICU daily rounding checklist to prompt a CXR order when clinically warranted. We built a report from billing codes, focusing on all CXRs obtained on IMV census days in the medical (MICU) and surgical (SICU) ICUs, excluding the day of admission and days that a procedure warranting CXR was performed. This generated the number of CXRs obtained every 1000 'included' ventilator days (IVDs), the latter defined as not having an 'absolute' clinical indication for CXR. <h3>Results</h3> The average monthly number of CXRs on an IVD decreased from 919±90 (95% CI 877 to 963) to 330±87 (95% CI 295 to 354) per 1000 IVDs in the MICU, and from 995±69 (95% CI 947 to 1055) to 649±133 (95% CI 593 to 697) in the SICU. This yielded an estimated 1830 to 2066 CXRs avoided over 2 years and an estimated annual savings of $191 600 to $224 200. There was no increase in reported adverse events. <h3>Conclusion</h3> ICUs can safely transition to a higher value strategy of indication-based chest imaging by educating staff, eliminating the 'daily' order option and adding a simplified prompt to avoid missing clinically indicated CXRs.
Rapid Acquisition of Multicellular Drug Resistance After a Single Exposure of Mammary Tumor Cells to Antitumor Alkylating Agents
Authors: C. H. Graham, H. Kobayashi, K. S. Stankiewicz, S. Man, S. J. Kapitain, R. S. Kerbel
Journal: JNCI Journal of the National Cancer Institute (1994)

Journal Article Rapid Acquisition of Multicellular Drug Resistance After a Single Exposure of Mammary Tumor Cells to Antitumor Alkylating Agents Get access Charles H. Graham, Charles H. Graham Cancer Research Division, Reichmann Research Building, Sunnybrook Health Science CentreToronto, Ontario, Canada Correspondence to : R. S. Kerbel. Cancer Research Division, Reichmann Research Building, Sunnybrook Health Science Centre, S-218. 2075 Bayview Ave., Toronto, ON. M4N 3M5 Canada. Search for other works by this author on: Oxford Academic PubMed Google Scholar Hiroaki Kobayashi, Hiroaki Kobayashi Cancer Research Division, Reichmann Research Building, Sunnybrook Health Science CentreToronto, Ontario, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar Krystyne S. Stankiewicz, Krystyne S. Stankiewicz Cancer Research Division, Reichmann Research Building, Sunnybrook Health Science CentreToronto, Ontario, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar Shan Man, Shan Man Cancer Research Division, Reichmann Research Building, Sunnybrook Health Science CentreToronto, Ontario, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar Sean J. Kapitain, Sean J. Kapitain Cancer Research Division, Reichmann Research Building, Sunnybrook Health Science CentreToronto, Ontario, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar R. S. Kerbel R. S. Kerbel Cancer Research Division, Reichmann Research Building, Sunnybrook Health Science Centre: and Department of Medical Biophysics and Department of Molecular and Medical Genetics, University of Toronto Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 86, Issue 13, 6 July 1994, Pages 975–982, https://doi.org/10.1093/jnci/86.13.975 Published: 06 July 1994 Article history Received: 31 January 1994 Accepted: 07 April 1994 Published: 06 July 1994
The Conquest of Smallpox
Authors: William R. Barclay
Journal: JAMA (1978)

Smallpox, once a major scourge, is now close to extinction. The eradication of this disease has been accomplished not by a recent scientific discovery but by a carefully planned international effort conducted by dedicated people. The actions that have led to this landmark achievement are described by Paul F. Wehrle, MD, in this issue ofThe Journal(p 1977). Since man is the only host for propagation of the smallpox virus, prevention of transmission to the point where no new cases are reported means eradication of all wild strains of the virus. The last recognized case of smallpox occurred in Birmingham, England, in August of this year. A laboratory photographer, Janet Parker, contracted the disease in the laboratory where she was employed and died Sept 11 in an isolation hospital. She had 39 close contacts, and 196 casual contacts were identified. These persons were closely followed up, but none have
IgE Anti-Varicella Virus (VZV) And Other Immune Responses Before, During, And After Shingles
Authors: H LEVTOV, J JOSEKUTTY, S KOHLHOFF, K NOROWITZ, J SILVERBERG, S CHICE, M NOWAKOWSKI, H DURKIN, M BLUTH, T SMITHNOROWITZ
Journal: Journal of Allergy and Clinical Immunology (2008)
Omissions, conflations, and false dichotomies: Conceptual and empirical problems with the Barbey &amp; Sloman account
Authors: Gary L. Brase
Journal: Behavioral and Brain Sciences (2007)

Abstract Both the theoretical frameworks that organize the first part of Barbey &amp; Sloman's (B&amp;S's) target article and the empirical evidence marshaled in the second part are marked by distinctions that should not exist (i.e., false dichotomies), conflations where distinctions should be made, and selective omissions of empirical results – within the very studies discussed – that create illusions of theoretical and empirical favor.
Psychiatric Consequences of September 11
Authors: Randall D. Marshall, Sandro Galea, Dean Kilpatrick
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
&lt;emph type="ital"&gt;View of the Brush House, Cos Cob, Connecticut&lt;/emph&gt;
Authors: M. Therese Southgate
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Severe cutaneous papillomavirus disease after haemopoietic stem-cell transplantation in patients with severe combined immune deficiency caused by common γc cytokine receptor subunit or JAK-3 deficiency
Authors: Caroline Laffort, Françoise Le Deist, Michel Favre, Sophie Caillat-Zucman, Isabelle Radford-Weiss, Sylvie Fraitag, Stéphane Blanche, Marina Cavazzana-Calvo, Geneviève de Saint Basile, Jean Pierre de Villartay, Silvia Giliani, Gérard Orth, Jean Laurent Casanova, Christine Bodemer, Alain Fischer, Marianne Debré
Journal: The Lancet (2004)
Urinary Myoglobin in Myocardial Infarction
Authors: Ernest C. Adams
Journal: JAMA (1970)

<h3>To the Editor:—</h3> This study was undertaken to determine whether analysis for myoglobin in consecutive urine specimens was sufficiently helpful in the diagnosis of myocardial infarction to displace current serum enzyme studies. In addition, we wanted information indicating its value to the clinician as an additional testing procedure in acute myocardial infarction. <h3>Methods.—</h3> At the start of the experiment, the first urine specimens were collected from all patients admitted to the intensive care ward of the Elkhart (Ind) General Hospital regardless of the diagnosis. Later, when it became apparent that the first specimen did not necessarily contain the most myoglobin, all urine was collected only from patients with suspected myocardial infarction. Antiserum to human myoglobin in the rabbit was prepared as described by Rozman et al,<sup>1</sup>and Rozman and Adams.<sup>2</sup>Conjugates of myoglobin covalently linked to formalinized sheep erythrocytes were prepared as described by Adams and Rozman.<sup>3</sup>
Fixed Defect on Rest/Stress Tc-99m Sestamibi Study Underestimates Myocardial Ischemia: Comparison With 24-Hour Thallium-201 Study for Short- and Intermediate-term Follow-up
Authors: Grace Kong, Meir Lichtenstein, Dishan Gunawardana, Nathan Better, Krisana Roysri, Dinesh Sivaratnam
Journal: Clinical Nuclear Medicine (2008)

Purpose: We assessed whether a same day rest/stress gated Tc-99m sestamibi (MIBI) SPECT myocardial study underestimates reversible ischemia in patients with fixed perfusion defects compared with a 24-hour thallium-201 (Tl-201) study. The short- and intermediate-term outcome with or without Tl-201 reversibility was assessed. Methods: Forty-nine consecutive patients with fixed MIBI defects received an additional Tl-201 study and were evaluated. Tl-201 was given to patients with a high clinical suspicion of underestimation of reversibility. Images were interpreted semiquantitatively by 3 nuclear medicine physicians using a 17-segment, 5-point model. A summed stress score (SSS) from stress MIBI images, a summed rest score (SRS) from Tl images, and a summed difference (SDS = SSS − SRS) score were calculated. SDS >3 indicated significant Tl-201 redistribution. Composite end points included acute myocardial infarction, unstable angina needing admission, cardiac death, or revascularization within 3 and 6 months. Results: Fifteen of 49 patients showed no Tl-201 redistribution. Thirty-four of 49 (69%) patients had significant Tl-201 redistribution, and these patients had significantly higher cardiac events (CE) at 3 months (29% vs. 7%; P = 0.039), and higher at 6 months (32% vs. 7%; P = 0.027). These patients with CE had a larger amount of Tl-201 redistribution, mean SDS 8.6 vs. 5.3 (P = 0.047). Patients with significant Tl-201 redistribution had a lower left ventricular ejection fraction (mean 37%; P = 0.001). Conclusion: With short- and intermediate-term follow-up, our study shows a significant association towards fixed defects on the rest/stress MIBI study underestimating CE risk when compared with a delayed Tl-201 study, especially in patients with a large amount of Tl-201 redistribution. Hence, the addition of a Tl-201 study may be useful in the management of patients with large fixed MIBI defects, especially with a depressed left ventricular ejection fraction.
1022-107 Outcome of Different Reperfusion Strategies in Thrombolytic “Eligible” versus “Ineligible” Patients with Acute Myocardial Infarction
Authors: Gregg W. Stone, Cindy L. Grines, Kevin F. Browne, Jean Marco, Donald Rothbaum, James O’Keefe, Paul Overlie, Brian Donohue, Sylvia Puchrowlcz, William W. O’Neill
Journal: Journal of the American College of Cardiology (1995)
Antibody binding to venom carbohydrates is a frequent cause for double positivity to honeybee and yellow jacket venom in patients with stinging-insect allergy
Authors: Wolfgang Hemmer, Margarete Focke, Daniel Kolarich, Iain B.H. Wilson, Friedrich Altmann, Stefan Wöhrl, Manfred Götz, Reinhart Jarisch
Journal: Journal of Allergy and Clinical Immunology (2001)
Criticality Accidents in Vinca, Yugoslavia, and Oak Ridge, Tennessee
Authors: Gould A. Andrews
Journal: JAMA (1962)

Major accidents involving radiation from nuclear reactors occurred in Oak Ridge, Tenn., and in Vinca, Yugoslavia, in 1958. The 2 accidents were in some ways similar, and both contributed information on the treatment of total-body radiation injury. After the Y-12 accident at Oak Ridge, the 5 exposed men recovered with supportive care. The 6 Yugoslavian radiation victims were moved to Paris, where 1 died, and 5, including 4 who had received bone-marrow injections, recovered. Efforts to evaluate the significance of the marrow treatment have involved consideration of physical measurements of radiation dose, biological evidence of severity of injury, and evidence for and against success of the marrow graft, but have not proved its value in these cases. A comparison of the 2 accidents helps to give perspective on these problems.
Switching prescription drugs to over the counter
Authors: Joshua P Cohen, Cherie Paquette, Catherine P Cairns
Journal: BMJ (2004)

<h3>Abstract</h3> N6-methyladenosine (m<sup>6</sup>A) is the most abundant modification on mRNA, and is implicated in critical roles in development, physiology and disease. The ability to map m<sup>6</sup>A using immunoprecipitation-based approaches has played a critical role in dissecting m<sup>6</sup>A functions and mechanisms of action. Yet, these approaches are of limited specificity, unknown sensitivity, and unable to quantify m6A stoichiometry. These limitations have severely hampered our ability to unravel the factors determining where m6A will be deposited, to which levels (the 'm6A code'), and to quantitatively profile m6A dynamics across biological systems. Here, we used the RNase MazF, which cleaves specifically at unmethylated RNA sites, to develop MASTER-seq for systematic quantitative profiling of m6A sites at 16-25% of all m6A sites at single nucleotide resolution. We established MASTER-seq for orthogonal validation and <i>de novo</i> detection of m6A sites, and for tracking of m6A dynamics in yeast gametogenesis and in early mammalian differentiation. We discover that antibody-based approaches severely underestimate the number of m6A sites, and that both the presence of m6A and its stoichiometry are 'hard-coded' via a simple and predictable code within the extended sequence composition at the methylation sites. This code accounts for ~50% of the variability in methylation levels across sites, allows excellent <i>de novo</i> prediction of methylation sites, and predicts methylation acquisition and loss across evolution. We anticipate that MASTER-seq will pave the path towards a more quantitative investigation of m6A biogenesis and regulation in a wide variety of systems, including diverse cell types, stimuli, subcellular components, and disease states.
A NEW TOOL FOR THE RISK STRATIFICATION OF PATIENTS WITH COMPLEX CORONARY ARTERY DISEASE: THE CLINICAL SYNTAX SCORE
Authors: Scot Garg, Giovanna Sarno, Chrysafios Girasis, Hector M. Garcia-Garcia, Joanna Wykrzykowska, Keith D. Dawkins, Patrick W. Serruys
Journal: Journal of the American College of Cardiology (2010)
Three-Phase Bone and Ga-67 Scintigraphy in Disseminated Sporotrichosis
Authors: VIJAY PATANGE, FERNANDO CESANI, JUSTIN PHILLPOTT, JAVIER VILLANUEVA-MEYER
Journal: Clinical Nuclear Medicine (1995)

A 27-year-old man, who had been shoveling gravel in southern Texas for 3 years, had a history of papules and nodules in the left lateral wall of the abdomen. The lesions increased in number and severity with spread to other regions of the body. A punch biopsy of the right arm lesion revealed intracellular, round and cigar shaped budding yeast. The cultures grew Sporotrichum schenkii. Three-phase bone imaging and a Ga-67 scan defined the extent of the disease including involvement of the right tibia, left second metacarpal, and the left wrist joints, the latter two of which were not apparent on clinical examination.
Abstract P6-14-11: ß-Catenin Inhibitor SST-024 Can Sensitize Breast Cancer Tumor Initiation Cells (TICs) to Ionized Radiotherapy
Authors: W Xu, BG Debeb, LC Alvarez de Lacerda, WA. Woodward
Journal: Cancer Research (2010)

Abstract Recent studies have shown that tumor initiation cells (TICs) are more resistant to ionized radiotherapy (IR) than differentiated cancer cells. In our lab, we have previously shown that aberrant Wnt signaling can contribute to radio-resistance of TICs in breast cancer. Herein, we use SST-024 (StemSynergy), an inhibitor of ß-catenin and WNT signaling, to test if pharmacologic inhibition of ß-catenin can sensitize breast cancer TICs to IR. Sum-149, an inflammatory breast cancer cell line, Sum-159, a non-inflammatory basal-type breast cancer cell line and IBC-3, a short-term cultured inflammatory breast cancer sample were used in these studies. We found that SST-024 inhibited Sum-149 mammosphere formation, a surrogate for TIC growth in vitro, at IC-50 0.3 nM while IC-50 for Sum-159 was 3 nM and IC-50 for IBC-3 was 4 nM. Similar efficacy against TICs was seen in assessments of alternative TIC surrogates including aldefluor staining by flow cytometry and CD44+CD24- marked cells. On immunoblot analysis SST-024 down-regulated unphosphorylated, active B-catenin and downstream target c-myc as well as EMT marks, including N-cadherin, Snail, Twist and Slug, and DNA repair regulator ATM. Moreover, standard monolayer and 3D mammospheres clonogenic assays demonstrate significant radiosensitization of SUM-149 TICs (mammospheres) as well as monolayer colony formation. In summary, SST-024 demonstrates significant efficacy against inflammatory breast cancer TICs and sensitize both TICs and non-TICs to IR implying targeting Wnt β-catenin signaling may be a feasible strategy to radiosensitize breast cancer TICs. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr P6-14-11.
Opticians: An Appeal to the Medical Profession.
Authors: Frank Van Fleet
Journal: JAMA (1904)

New York City, Jan. 16, 1904. <h3>To the Editor:</h3> —An optical society, composed of so-called "refracting opticians," has issued a circular letter to the medical profession, asking for the endorsement of a bill about to be introduced in the legislature, legalizing the "practice of optometry." This measure is not a new thing; we have met it several times in the past, and it has only been necessary to expose its pernicious features to defeat it. It will be necessary to do this again and again until the public awakens to the fact that measures such as this are only the efforts of incompetent people to evade the medical laws in order that they may prey on the community without fear of molestation, and then suitable provisions will be made to suppress them. It is to be hoped that members of the medical profession will not be influenced by the specious
Regulating new psychoactive drugs: innovation leading to compromise
Authors: L. J. Schep, P. Gee, M. Tingle, S. Galea, D. Newcombe
Journal: BMJ (2014)

Owing to the increasing availability of new, and legal, psychoactive drugs (NPDs),1 the New Zealand government enacted ground breaking legislation in May 2013; the Psychoactive Substance Act requires evidence of low risk before NPDs can be legally sold.2 3 A transitional period was created until safety testing regimes were finalised. Public outrage, however, grew as adverse effects of “interim approved” drugs …