The Detection of Intestinal Absorption of Co^57 Tagged Vitamin B_12 by Serum Counting
Authors: PAUL R. MCCURDY
Journal: Annals of Internal Medicine (1965)

Article1 January 1965The Detection of Intestinal Absorption of Co57 Tagged Vitamin B12 by Serum CountingPAUL R. MCCURDY, M.D.PAUL R. MCCURDY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-1-97 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe usual cause for vitamin B12deficiency is its specific malabsorption caused by lack of gastrict intrinsic factor. Nonsurgical deficiency of intrinsic factor is pernicious anemia. The Schilling test was devised to measure gastrointestinal absorption of vitamin B12(1). In it is measured the radioactivity flushed out in the urine during the 24 hours after the oral administration of B12tagged with a radioactive isotope of cobalt. To differentiate true Addisonian pernicious anemia from other causes of failure to absorb vitamin B12unrelated to the secretion of gastric intrinsic factor, one should repeat an abnormal Schilling test and give a...References1. SCHILLING RF: Intrinsic factor studies, II. The effect of gastric juice on the urinary excretion of radioactivity after the oral administration of radioactive vitamin B-12. J. Lab. Clin. Med. 42: 860, 1953. MedlineGoogle Scholar2. RATHMCCURDYDUFFY CEPRBJ: Effect of renal disease on the Schilling test. New Eng. J. Med. 256: 111, 1957. CrossrefMedlineGoogle Scholar3. DOSCHERHOLMENHAGEN APS: A dual mechanism of vitamin B-12 absorption. J. Clin. Invest. 36: 1551, 1957. CrossrefMedlineGoogle Scholar4. BESTLANDMANNLIMARZI WRWALR: Time pattern of vitamin B-12 Co60 urinary excretion in man after oral administration and parenteral "flushing." Blood 11: 352, 1956. CrossrefMedlineGoogle Scholar5. EBERLEGLEASON BTGI: Cobalt57 labeled vitamin B-12 and its advantages in regard to radiation absorbed doses to the liver and counting efficiency. Clin. Res. 8: 208, 1960. Google Scholar6. DOSCHERHOLMENHAGEN APS: Radioactive vitamin B-12 absorption studies: results of direct measurement of radioactivity in the blood. Blood 12: 336, 1957. CrossrefMedlineGoogle Scholar7. GOLDBERGTRIVEDIOLIVER SRBKL: Radioactive vitamin B-12 studies. Experience with the urinary excretion test and the measurement of absorbed plasma radioactivity. J. Lab. Clin. Med. 49: 583, 1957. MedlineGoogle Scholar8. KRISTENSENØSTERGAARDHALD HPJT: Measurement of plasma radioactivity following oral administration of 57Co-labelled B-12. Danish Med. Bull. 9: 167, 1962. MedlineGoogle Scholar9. NELPMCAFEEWAGNER WBJGHN: Single measurement of plasma radioactive vitamin B-12 as a test for pernicious anemia. J. Lab. Clin. Med. 61: 158, 1963. MedlineGoogle Scholar10. HERBERT V: Curent concepts in therapy: megaloblastic anemia (concluded). New Eng. J. Med. 268: 368, 1963. CrossrefMedlineGoogle Scholar11. MCCURDY PR: Simultaneous Schilling tests with and without intrinsic factor using B-12 labelled with Co57 and with Co60. Clin. Res. 12: 33, 1964. Google Scholar12. ADAMSCARTWRIGHT JFEJ: The reliability and reproducibility of the Schilling test in primary malabsorption disease and after partial gastrectomy. Gut 4: 32, 1963. CrossrefMedlineGoogle Scholar13. MCCURDYPIERCERATH PRLECE: Abnormal bone-marrow morphology in acute alcoholism. New Eng. J. Med. 266: 505, 1962. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Washington, D. C.From the Georgetown Medical Division, District of Columbia General Hospital, Washington, D. C., and the Department of Medicine, Georgetown University School of Medicine, Washington, D. C.This work was supported in part by a grant AM 02823 from the National Institute of Arthritis and Metabolic Disease, National Institutes of Health, U. S. Public Service, Bethesda, Md.Requests for reprints should be addressed to Paul R. McCurdy, M.D., Government of the District of Columbia, D. C. General Hospital, 19th Street and Massachusetts Ave., Washington, D. C. 20003. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCyclotron production of carrier-free cobalt-55, a new positron-emitting label for bleomycinVitamin B12 Absorption Evaluated by a Dual Isotope Test (Dicopac®) Results of Radioactivity Measurements in Plasma and in UrineFailed Schilling TestsDISCREPANCIES BETWEEN THE URINARY–EXCRETION AND PLASMA–LEVEL METHODS OF MEASURING VITAMIN B 12 ABSORPTIONPernicious Anemia in NegroesRICHARD J. HART JR., M.D., PAUL R. MCCURDY, M.D.Studies on the 57Co vitamin B12 plasma level absorption testDifferential diagnosis and management of the patient with megaloblastic anemiaVITAMIN B 12 ABSORPTION STUDIES: COMPARISON OF 57 CO VITAMIN B 12 PLASMA LEVELS WITH AND WITHOUT PARENTERAL VITAMIN B 12Plasma Radioactivity following Oral Administration of 57 Co-Labelled Vitamin B 12Folates in Human NutritionFolates in Human NutritionMeasurement of intestinal absorption of 57Co vitamin B12 by serum counting 1 January 1965Volume 62, Issue 1Page: 97-102KeywordsExcretionHospital medicineMetabolic disordersOral administrationPernicious anemiaPrevention, policy, and public healthResearch laboratoriesRiversUrineVitamin B12 deficiency Issue Published: 1 January 1965 PDF downloadLoading ...