High-Dose Cyclophosphamide for Treatment of Aplastic Anemia
Authors: Robert A. Brodsky, Richard J. Jones
Journal: Annals of Internal Medicine (2002)

Letters17 September 2002High-Dose Cyclophosphamide for Treatment of Aplastic AnemiaRobert A. Brodsky, MD and Richard J. Jones, MDRobert A. Brodsky, MDSidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Baltimore, MD 21231Search for more papers by this author and Richard J. Jones, MDSidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Baltimore, MD 21231Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-137-6-200209170-00031 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Over 15 years ago, a prospective, controlled study by Speck and colleagues suggested that antilymphocyte globulin was superior to allogeneic bone marrow transplantation for aplastic anemia (1). Initially embraced by many, the conclusions of this study have not stood the test of time, and bone marrow transplantation is now the preferred treatment for patients with matched siblings.The randomized, controlled trial can be limited by the details of study design and execution. The NIH trial reported 6-month data on just 13 patients treated with cyclophosphamide and cyclosporine and just 12 patients treated with ATG and cyclosporine. The study ...References1. Speck B, Gratwohl A, Nissen C, Osterwalder B, Würsch A, Tichelli A, et al . Treatment of severe aplastic anemia. Exp Hematol. 1986;14:126-32. [PMID: 3510893] MedlineGoogle Scholar2. Deeg HJ, Shulman HM, Schmidt E, Yee GC, Thomas ED, Storb R. Marrow graft rejection and veno-occlusive disease of the liver in patients with aplastic anemia conditioned with cyclophosphamide and cyclosporine. Transplantation. 1986;42:497-501. [PMID: 3538535] CrossrefMedlineGoogle Scholar3. Nomoto K, Eto M, Yanaga K, Nishimura Y, Maeda T, Nomoto K. Interference with cyclophosphamide-induced skin allograft tolerance by cyclosporin A. J Immunol. 1992;149:2668-74. [PMID: 1401906] MedlineGoogle Scholar4. Brodsky RA, Sensenbrenner LL, Jones RJ. Complete remission in severe aplastic anemia after high-dose cyclophosphamide without bone marrow transplantation. Blood. 1996;87:491-4. [PMID: 8555470] CrossrefMedlineGoogle Scholar5. Rosenfeld SJ, Kimball J, Young NS. Long-term outcomes after treatment of severe aplastic anemia with antithymocyte globulin and cyclosporin [Abstract]. Blood. 1995;86:477a. Google Scholar Author, Article, and Disclosure InformationAffiliations: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Baltimore, MD 21231 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoDurable Treatment-Free Remission after High-Dose Cyclophosphamide Therapy for Previously Untreated Severe Aplastic Anemia Robert A. Brodsky , Lyle L. Sensenbrenner , B. Douglas Smith , Donna Dorr , Phillip J. Seaman , Shing M. Lee , Judith E. Karp , Isadore Brodsky , and Richard J. Jones High-Dose Cyclophosphamide for Treatment of Aplastic Anemia Neal S. Young and John F. Tisdale Metrics 17 September 2002Volume 137, Issue 6Page: 550KeywordsAplastic anemiaBone marrow transplantationCyclophosphamideDeath ratesGlobulinsPatientsPopulation statisticsProspective studiesResearch designToxicity ePublished: 17 September 2002 Issue Published: 17 September 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...