tbuckley/cabot-search huggingface dataset:
Detection of Recurrent Colorectal Carcinoma With In-111 CYT-103 Scintigraphy in a Patient With Nondiagnostic MRI and CT
Authors: JAMES P. EDLIN, DANIEL KAHN
Journal: Clinical Nuclear Medicine (1994)

Detection of recurrent colorectal carcinoma can be a diagnostic challenge. The authors report a case of a patients who, after resection of his primary colorectal carcinoma, had a recurrence that was not detected by MRI or serial CT examination, but was clearly demonstrated by in-111 labeled CYT-103 scintigraphy. This case demonstrates the use of CYT-103 scintigraphy in detecting recurrent colorectal cancer in a patient, despite results of nondiagnostic MRI or serial CT examinations.
Obituary. Hans Popper, MD, PhD
Authors: D. Iselin
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
In Vitro Fertilization: Building Policy From Laboratories to Legislatures
Authors: David Orentlicher
Journal: JAMA (1990)

As we enter the third decade of in vitro fertilization (IVF) (p 5), public events continually reinforce the need of society to establish ethical and legal guidelines for its use. A few years ago, the Rios couple died in a plane crash, leaving uncertain the appropriate disposition of their frozen preembryos. Currently, the Davis court case in Tennessee reflects a lack of consensus on the status of a preembryo or the appropriate disposition of frozen preembryos when the couple who created them can no longer agree on their use. In her carefully researched book, Andrea Bonnicksen identifies in a comprehensive way the policy choices that confront society in its use of IVF. She points out the need to determine the nature of the right to conceive, to balance the regulatory roles of government and the medical profession, and to ensure that we are not driven in our use of IVF
The Beneficence of Neonatal Hematopoiesis
Authors: David G. Nathan
Journal: New England Journal of Medicine (1989)

THE fetus and the newborn are highly endowed with the capacity to produce blood,1 and the site-specific stages and switches through which the accelerated blood production moves during development2 are becoming particularly fascinating as the regulatory proteins that influence them are identified.3 The production of red cells begins in the yolk sac only a few weeks after conception. Yolk-sac erythrocytes are very large nucleated cells that uniquely express the products of certain genes, such as embryonic globin. When hematopoiesis is completed in the yolk sac, it moves on to the liver, and that organ fills with nucleated red cells. Relatively . . .
Membrane skeletal alterations during in vivo mouse red cell aging. Increase in the band 4.1a:4.1b ratio.
Authors: T J Mueller, C W Jackson, M E Dockter, M Morrison
Journal: Journal of Clinical Investigation (1987)

We have examined membrane protein profiles for alterations during red blood cell aging. To obtain populations of in vivo-aged red cells, we maintained mice in a state of continuous erythropoietic suppression for up to 8 wk using serial hypertransfusion. The circulating t1/2 of red cells from mice which had been erythropoietically suppressed for 8 wk was less than 1 d compared with a t1/2 of 15 d for red cells from normal animals. The most obvious alteration in membrane proteins was an increase in the ratio of the membrane skeletal components 4.1a:4.1b from 0.3 for the normal red cell population to greater than 1 for these old cells. The 4.1a:4.1b ratio thus appears to be a useful index of red cell age. Analyses of the density profile of cells aged in the hypertransfused mice disclosed that these old cells had a density range similar to that of controls, suggesting that cell density does not increase significantly with red cell age in the mouse.
IRF4 Transcription-Factor-Dependent CD103+CD11b+ Dendritic Cells Drive Mucosal T Helper 17 Cell Differentiation
Authors: Emma K. Persson, Heli Uronen-Hansson, Monika Semmrich, Aymeric Rivollier, Karin Hägerbrand, Jan Marsal, Sigurdur Gudjonsson, Ulf Håkansson, Boris Reizis, Knut Kotarsky, William W. Agace
Journal: Immunity (2013)

CD103+CD11b+ dendritic cells (DCs) represent the major migratory DC population within the small intestinal lamina propria (SI-LP), but their in vivo function remains unclear. Here we demonstrate that intestinal CD103+CD11b+ DC survival was dependent on interferon regulatory factor 4 (IRF4). Mice with a DC deletion in Irf4 displayed reduced numbers of intestinal interleukin 17 (IL-17)-secreting helper T 17 (Th17) cells and failed to support Th17 cell differentiation in draining mesenteric lymph nodes (MLN) following immunization. The latter was associated with a selective reduction in CD103+CD11b+ MLN DCs and DC derived IL-6. Immunized Il6−/− mice failed to support Th17 cell differentiation in MLN in vivo and CD103+CD11b+ MLN DCs supported IL-6-dependent Th17 cell differentiation in vitro. Together, our results suggest a central role for IRF4-dependent, IL-6 producing CD103+CD11b+ DCs in intestinal Th17 cell differentiation.
Atypical Trigeminal Neuralgia Associated With Tongue Piercing
Authors: Roberto Gazzeri, Sandro Mercuri, Marcelo Galarza
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Permanent Interstitial Low-Dose-Rate Brachytherapy for Patients with Localised Prostate Cancer: A Systematic Review of Randomised and Nonrandomised Controlled Clinical Trials
Authors: Frank Peinemann, Ulrich Grouven, Carmen Bartel, Stefan Sauerland, Holger Borchers, Michael Pinkawa, Axel Heidenreich, Stefan Lange
Journal: European Urology (2011)
Hypoxia Is the Cause of Brain Damage in Hyponatremia
Authors: James P. Knochel
Journal: JAMA (1999)

rior surface dust lead, interior house dust lead and childhood lead exposure in an urban environment. In: Hemphill DD, ed. Trace Substances in Environmental Health, XX: Proceedings of University of Missouri’s 20th Annual Conference, June 1986. Columbia: University of Missouri; 1987:322-332. 23. Environmental Protection Agency. Distribution of Soil Lead in the Nation’s Housing Stock. Washington, DC: Office of Pollution Prevention and Toxics. Environmental Protection Agency; 1996. Report No. EPA 747-R-96-003. 24. Department of Housing and Urban Development. Comprehensive and Workable Plan for the Abatement of Lead-Based Paint in Privately Owned Housing, Report to Congress. Washington, DC: Office of Policy Development and Research; 1990.
Pay freeze and superannuation benefits
Authors: B. Ross
Journal: BMJ (1975)

The legal profession in the UK is an ex- ample of unfettered free entenprise.It is true, of course, that legal aid is available, but it makes little impact on the average citizen.Liberty is one essential aspect of the definition of a profession, based as it is upon the concept of service.Yet at this time the Government and Labour Party are obsessed with eliminating the last vestigial remnants of professional freedom from the medical profession.In contrast, however, there are no Government proposals at all to meet the demands of a mass population for legal advice.
Impact of <i>Burkholderia</i> Infection on Lung Transplantation in Cystic Fibrosis
Authors: Susan Murray, Jeffery Charbeneau, Bruce C. Marshall, John J. LiPuma
Journal: American Journal of Respiratory and Critical Care Medicine (2008)

Rationale: Lung transplantation offers the only survival option for patients with cystic fibrosis (CF) with end-stage pulmonary disease. Infection with Burkholderia species is typically considered a contraindication to transplantation in CF. However, the risks posed by different Burkholderia species on transplantation outcomes are poorly defined.Objectives: To quantify the risks of infection with Burkholderia species on survival before and after lung transplantation in patients with CF.Methods: Multivariate Cox survival models assessed hazard ratios of infection with Burkholderia species in 1,026 lung transplant candidates and 528 lung transplant recipients. Lung allocation scores, incorporating Burkholderia infection status, were calculated for transplant candidates.Measurements and Main Results: Transplant candidates infected with different Burkholderia species did not have statistically different mortality rates. Among transplant recipients infected with B. cenocepacia, only those infected with nonepidemic strains had significantly greater post-transplant mortality compared with uninfected patients (hazard ratio [HR], 2.52; 95% confidence interval [CI], 1.04–6.12; P = 0.04). Hazards were similar between uninfected transplant recipients and those infected with B. multivorans (HR, 0.66; 95% CI, 0.27–1.56; P = 0.34). Transplant recipients infected with B. gladioli had significantly greater post-transplant mortality than uninfected patients (HR, 2.23; 95% CI, 1.05–4.74; P = 0.04). Once hazards for species/strain were included, lung allocation scores of B. multivorans–infected transplant candidates were comparable to uninfected candidate scores, whereas those of candidates infected with nonepidemic B. cenocepacia or B. gladioli were lower.Conclusions: Post-transplant mortality among patients with CF infected with Burkholderia varies by infecting species. This variability should be taken into account in evaluating lung transplantation candidates.
PI3K-FRAP/mTOR pathway is critical for hepatocyte proliferation whereas MEK/ERK supports both proliferation and survival
Authors: Alexandre Coutant, Claude Rescan, David Gilot, Pascal Loyer, Christiane Guguen-Guillouzo, Georges Baffet
Journal: Hepatology (2002)

Growth factors are known to favor both proliferation and survival of hepatocytes. In this work, we investigated the role of 2 main signaling pathways, phosphoinositide 3-kinase (PI3K) and mitogen-activated protein kinase (MEK)/extracellular signal-regulated kinase (ERK), in these processes. First, evidence was provided that the PI3K cascade as well as the MEK/ERK cascade is a key transduction pathway controlling hepatocyte proliferation, as ascertained by arrest of DNA synthesis in the presence of LY294002, a specific PI3K inhibitor. Inhibition of FRAP/mTOR by rapamycin also abrogated DNA replication and protein synthesis induced by growth factor. We showed that expression of cyclin D1 at messenger RNA (mRNA) and protein levels was regulated by this pathway. We highlighted that 4E-BP1 phosphorylation was not activated by epidermal growth factor (EGF) but was under an insulin-regulation mechanism through a PI3K-FRAP/mTOR activation that could account for the permissive role of insulin on hepatocyte proliferation. No interference between the MEK/ERK pathway and 4E-BP1 phosphorylation was detected, whereas p70S6K phosphorylation induced by EGF was under a U0126-sensitive regulation. Last, we established that the antiapoptotic function of EGF was dependent on MEK, whereas LY294002 and rapamycin had no direct effect on cell survival. Taken together, these data highlight the regulation and the role of 2 pathways that mediate growth-related response by acting onto distinct steps. In conclusion, hepatocyte progression in late G1 phase induced by EGF generates survival signals depending on MEK activation, whereas PI3K and MEK/ERK cascades are both necessary for hepatocyte replication.
Myocardial oxygen consumption, oxygen supply/demand heterogeneity, and microvascular patency in regionally stunned myocardium.
Authors: L D Stahl, H R Weiss, L C Becker
Journal: Circulation (1988)

Although oxygen consumption closely parallels mechanical work in the normal heart, previous studies have found that stunned myocardium may have normal or even increased oxygen consumption despite depressed function. In this study we used microspectrophotometry to measure the oxygen saturations within arteries and veins of less than 100 micron diameter in quick-frozen biopsy samples from normal and regionally stunned myocardium of 10 open-chest anesthetized dogs. Regional myocardial blood flow, measured by radioactive microspheres, was similar in stunned and normal regions, as was mean arteriolar oxygen saturation. However, mean venous oxygen saturation was lower in the stunned region (epicardium 38.0% vs 43.8%, p less than .02; endocardium 36.2% vs 39.5%, p = .12), indicating increased oxygen extraction and consumption, despite a marked reduction in mean systolic segmental shortening from 14.4% to 0.5%. In addition, there was greater vein-to-vein heterogeneity of oxygen saturation in the stunned region, with an excess of veins having low saturations (statistically significant in epicardium, nonsignificant trend in endocardium). Microvascular injections studies with Microfil or drafting ink revealed filling of over 95% of arterioles and 85% of capillaries in the stunned region, similar to the findings in the normal region. Our results are consistent with an inefficient transfer of energy into myocyte contraction or an increased use of energy for noncontractile activities in stunned myocardium. In addition, the finding of increased heterogeneity of oxygen extraction suggests that the injury to stunned myocardium may not be uniform to all contractile elements, but instead may be focally and irregularly distributed.
Elective porto-caval shunt (PCS) vs variceal sclerosis (VS) for the treatment of G-I bleeding in liver cirrhosis (LC)
Authors: R. Planas, J. Boix, M. Broggi, E. Cabré, R. Morillas, M. Armengol, R. de León, P. Humbert, J.A. Salva, M.A. Gassull
Journal: Journal of Hepatology (1989)
Modes of Admission to Hospital: A Survey of Emergency Admissions to a General Medical Unit
Authors: A. R. Patel
Journal: BMJ (1971)

In a survey of the modes of referral and disposal of “acute patients” to a general medical unit during the period 1 February 1968 to 31 July 1970 only 1,432 out of 3,455 were referred by general practitioners. There was a high incidence of self-referral to hospital, and this trend was on the increase. A large percentage of self-referred patients came from their homes, and 65-77% of these arrived by ambulance ordered by themselves.
Minimal standard terminology for gastrointestinal endoscopy – <i>MST 3.0</i>
Authors: Lars Aabakken, Bjorn Rembacken, Olivier LeMoine, Konstantin Kuznetsov, Jean-Francois Rey, Thomas Rösch, Glen Eisen, Peter Cotton, Masayuki Fujino
Journal: Endoscopy (2009)

Standardization of the language of gastrointestinal endoscopy is becoming increasingly important on account of international collaboration, standardized documentation requirements, and computer-based reporting. Version 1 of the Minimal Standard Terminology (MST) was devised to facilitate this development, and, through broad international collaboration, the document was developed and tested further to produce version 2.0, published in 2000. The document forms the basis for computer software by offering standard minimal lists of terms to be used in the structured documentation of endoscopic findings. The ownership of the MST has been transferred to the World Organisation of Digestive Endoscopy (OMED) and in this context, a new revision of the MST document is now in place. Version 3.0 of the terminology includes terms for endoscopic ultrasound (EUS) and enteroscopy, as well as for adverse event reporting. In addition, acknowledged scoring systems have been included for specific findings, and some structural enhancements have been implemented. The entire document is freely available for noncommercial use from www.omed.org.
Patterns of lung and heart growth as determined from serial radiographs of 76 children with cystic fibrosis
Authors: M. B. Mearns, G. Simon
Journal: Thorax (1973)

<b>Mearns, M.B., and Simon, G. (1973).</b><i>Thorax</i>, <b>28</b>, 537-546. <b>Patterns of lung and heart growth as determined from serial radiographs of 76 children with cystic fibrosis.</b> Chest radiographs of 76 children with cystic fibrosis were taken each year to determine lung length, lung width, and heart diameter. These measurements were plotted on standard charts against age and studied in relation to the initial clinical status. The changes in the pattern of growth which occurred during a follow-up period of 4 to 9 years (average 7 years) were considered in relation to clinical changes and change in ventilatory capacity. It was found that at 6 years of age the majority of patients had a lung width greater and heart diameter smaller than might have been expected. During the follow-up a decrease in lung width occurred without a proportionate increase in lung length. The lateral view radiographs did not show flattening of the diaphragm, and in the majority no other changes were found which would suggest marked overdistension of the lungs or increase in AP diameter. One group of patients was found not to be increasing vital capacity with increasing height, although they did not demonstrate the clinical findings usually associated with progression of the pulmonary infection in cystic fibrosis. The lung measurement showed a greater decrease in lung width and more marked narrowing of the heart shadow than occurred in the other patients, irrespective of the progression of the pulmonary involvement. The significance of these findings has not been determined.
Molecular and functional definition of the developing human striatum
Authors: Marco Onorati, Valentina Castiglioni, Daniele Biasci, Elisabetta Cesana, Ramesh Menon, Romina Vuono, Francesca Talpo, Rocio Laguna Goya, Paul A Lyons, Gaetano P Bulfamante, Luca Muzio, Gianvito Martino, Mauro Toselli, Cinthia Farina, Roger A Barker, Gerardo Biella, Elena Cattaneo
Journal: Nature Neuroscience (2014)
Serum C-Reactive Protein Level Is Associated With Abdominal Aortic Aneurysm Size and May Be Produced by Aneurysmal Tissue
Authors: Tryfon Vainas, Tim Lubbers, Frank R.M. Stassen, Selma B. Herngreen, Marja P. van Dieijen-Visser, Cathrien A. Bruggeman, Peter J.E.H.M. Kitslaar, Geert Willem H. Schurink
Journal: Circulation (2003)

Abdominal aortic aneurysms (AAA) are characterized by extensive transmural inflammation and C-reactive protein (CRP) has emerged as an independent risk factor for the development of cardiovascular disease. Therefore, we evaluated a possible association between serum CRP and aneurysm dimension in patients with asymptomatic AAA. Furthermore, the possibility of CRP production by aneurysmal tissue has been examined.Serum CRP was determined highly sensitive (hsCRP) and aneurysmal size was measured in 39 patients with AAA. The presence of CRP mRNA was assessed in the aneurysmal tissue of 16 patients. Mean (SD) hsCRP was 3.23 (2.96) mg/L. After log-transformation, hsCRP correlated significantly with aneurysmal size (r=0.477, P=0.002). When the patients were divided into 3 equally sized groups according to hsCRP level, aortic diameter increased from lowest to upper hsCRP-tertile (49 mm, 61 mm, and 67 mm, respectively; P<0.05 for 3rd versus 1st tertile). This association persisted after correction for risk factors. CRP mRNA was found in 25% of aneurysmal aortic tissues.This is the first report showing that serum hsCRP is associated with aneurysmal size and that-in at least some patients-CRP may be produced by aneurysmal tissue. These data underscore the inflammatory nature of AAA formation, suggesting that serum hsCRP may serve as a marker of AAA disease and that CRP produced in vascular tissue might contribute to aneurysm formation.
Hypermethylation of a Small CpGuanine-Rich Region Correlates with Loss of Activator Protein-2α Expression during Progression of Breast Cancer
Authors: Donna B. Douglas, Yoshimitsu Akiyama, Hetty Carraway, Steven A. Belinsky, Manel Esteller, Edward Gabrielson, Sigmund Weitzman, Trevor Williams, James G. Herman, Stephen B. Baylin
Journal: Cancer Research (2004)

Abstract The transcription factor activator protein-2α (AP-2α) has recently been implicated as a tumor suppressor protein that can be lost during tumor progression and that exhibits growth-inhibitory properties when overexpressed in cancer cell lines. We now demonstrate that hypermethylation of a discrete 5′ region within a promoter CpG island of the gene is associated in breast cancer with the loss of AP-2α expression. Multiple CpG sites within the island become hypermethylated during breast cancer evolution. However, only hypermethylation of the most CpG-rich region, a small, ∼300-bp area at the 3′ end of exon 1, fully distinguishes neoplastic from normal breast tissue and correlates with transcriptional silencing. In cell culture, silenced AP-2α, associated with exon 1 hypermethylation, is re-expressed by 5-aza-2′deoxycytidine resulting in the restoration of a functional DNA sequence-specific binding protein. In vivo, as detected by a very sensitive nested PCR approach, methylation of the discrete AP-2α exon 1 region does not occur in normal breast epithelium and occurs in only 3 (16%) of 19 ductal carcinoma in situ (DCIS) lesions, but is present in 12 (75%) of 16 invasive breast tumors (P &amp;lt; 0.001; DCIS versus invasive cancers). Tumors unmethylated for this region expressed AP-2α protein throughout, whereas tumors with hypermethylation showed large areas of loss. Our studies then determine that hypermethylation of a small region of a CpG island correlates with silencing of AP-2α in breast cancer and suggest that inactivation of this gene could be a factor in, and a useful marker for, the progression of DCIS lesions.