Isotretinoin in Respiratory Papillomatosis
Authors: Cynthia Osborne, Herve LeBoeuf, Dennie V. Jones
Journal: Annals of Internal Medicine (2000)

Letters20 June 2000Isotretinoin in Respiratory PapillomatosisCynthia Osborne, MD, Herve LeBoeuf, MD, and Dennie V. Jones Jr., MDCynthia Osborne, MDUniversity of Texas Medical Branch; Galveston, TX 77555-0565 (Osborne)University of Texas Medical Branch; Galveston, TX 77555-0565 (LeBoeuf)University of Texas Medical Branch; Galveston, TX 77555-0565 (Jones)Search for more papers by this author, Herve LeBoeuf, MDUniversity of Texas Medical Branch; Galveston, TX 77555-0565 (Osborne)University of Texas Medical Branch; Galveston, TX 77555-0565 (LeBoeuf)University of Texas Medical Branch; Galveston, TX 77555-0565 (Jones)Search for more papers by this author, and Dennie V. Jones Jr., MDUniversity of Texas Medical Branch; Galveston, TX 77555-0565 (Osborne)University of Texas Medical Branch; Galveston, TX 77555-0565 (LeBoeuf)University of Texas Medical Branch; Galveston, TX 77555-0565 (Jones)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-12-200006200-00028 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Retinoids can reduce the risk for second primary tumors of the head and neck and may reverse dysplasia of the aerodigestive tract mucosa, a premalignant condition.An 81-year-old nonsmoking woman was referred for consideration of isotretinoin therapy for severe tracheal dysplasia associated with recurrent papillomatosis. Over the previous two decades, she had required 113 surgical procedures to clear her upper airway of rapidly recurring papillomas; her disease had progressed despite therapy with cyclophosphamide and recombinant human interferon-α. She began receiving isotretinoin, 2 mg/kg of body weight per day Monday through Friday for 3 months. The dosage was ...References1. Avidano MA, Singleton GT. Adjuvant drug strategies in the treatment of recurrent respiratory papillomatosis. Otolaryngol Head Neck Surg. 1995;112:197-202. CrossrefMedlineGoogle Scholar2. Bell R, Hong WK, Itri LM, McDonald G, Strong MS. The use of cis-retinoic acid in recurrent respiratory papillomatosis of the larynx: a randomized pilot study. Am J Otolaryngol. 1988;9:161-4. CrossrefMedlineGoogle Scholar3. Eicher SA, Taylor-Cooley LD, Donovan DT. Isotretinoin therapy for recurrent respiratory papillomatosis. Arch Otolaryngol Head Neck Surg. 1994;120:405-9. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: University of Texas Medical Branch; Galveston, TX 77555-0565 (Osborne)University of Texas Medical Branch; Galveston, TX 77555-0565 (LeBoeuf)University of Texas Medical Branch; Galveston, TX 77555-0565 (Jones) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAn updated review of the epidemiological factors associated with recurrent respiratory papillomatosisPapillomatosi della laringe negli adultiPapilomatosis laríngea del adultoRecurrent Respiratory PapillomatosisPapillomatose laryngéePapilomatosis laríngeaPapillomatosi laringeaPharmacotherapy of recurrent respiratory papillomatosis: an expert opinionCidofovir for the Treatment of Recurrent Respiratory Papillomatosis: A Review of the Literature 20 June 2000Volume 132, Issue 12Page: 1007KeywordsBody weightCyclophosphamideDysplasiaHead and neck tumorsInterferonsMucous membranesPruritusRespiratory system proceduresRetinoidsSurgical resection Issue Published: 20 June 2000 CopyrightCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...