In Vitro Effectiveness of Kanamycin and Kanamycin/Cephalothin Against<i>Klebsiella</i>
Authors: ROGER J. BULGER
Journal: Annals of Internal Medicine (1967)

Article1 September 1967In Vitro Effectiveness of Kanamycin and Kanamycin/Cephalothin Against KlebsiellaComparison with Other AntibioticsROGER J. BULGER, M.D.ROGER J. BULGER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-3-523 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn the treatment of klebsiella pneumonia, authorities frequently recommend tetracycline, chloramphenicol, and combinations of streptomycin/tetracycline or streptomycin/chloramphenicol (1, 2). Many strains of Klebsiella are sensitive to cephalothin, and this agent has been used with increasing frequency in klebsiella pneumonias and urinary tract infections (3, 4). Benner, Mickelwait, Brodie, and Kirby (5) observed in vitro an extraordinarily rapid development of resistance to cephalothin by Klebsiella strains and predicted that increasing numbers of clinical isolates of Klebsiella would show resistance to cephalothin.One of the advantages of antibiotic combinations is that they delay the emergence of resistant strains. Several studies have indicated that...References1. BENNETT IL: Klebsiella infections, in Principles of Internal Medicine, edited by HARRISON, T. R., ADAMS, R. D., BENNETT, I. L., RESNIK, W. H., THORN, G. W., WINTROBE, M. M. McGraw-Hill Book Co., Inc., New York, 1966, p. 1548. Google Scholar2. BARBERGARROD MLP: Antibiotic and Chemotherapy. E. & S. Livingston, Ltd., Edinburgh and London, 1963, p. 271. Google Scholar3. TURCKANDERSONSMITHWALLACEPETERSDORF MKNRHJFRG: Laboratory and clinical evaluation of a new antibiotic—cephalothin. Ann. Intern. Med. 63: 199, 1965. LinkGoogle Scholar4. 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KAYEKOENIGHOOK DMGEW: The action of certain antibiotics and antibiotic combinations against Proteus mirabilis with demonstration of in vitro synergism and antagonism. Amer. J. Med. Sci. 242: 320, 1961. CrossrefMedlineGoogle Scholar10. BULGERKIRBY RJWM: Gentamicin and ampicillin: synergism with other antibiotics. Amer. J. Med. Sci. 246: 717, 1963. CrossrefMedlineGoogle Scholar11. EDWARDSEWING PRWH: Identification of the Enterobacteriaceae, 2nd ed. Burgess Publishing Co., Minneapolis, 1962. Google Scholar12. WILSONMILES GSAA: Topley and Wilson's Principles of Bacteriology and Immunity. The Williams & Wilkins Co., Baltimore, 1964, pp. 66-74. Google Scholar13. LACEY BW: The rationale and management of combined therapy. Brit. Med. Bull. 16: 42, 1960. CrossrefMedlineGoogle Scholar14. JAWETZGUNNISON EJ: Studies on antibiotic synergism and antagonism: a scheme of combined antibiotic action. Antibiot. Chemother. (Basel) 2: 243, 1952. Google Scholar15. WEILSHUBINBIDDLE MHHM: Shock caused by gram-negative microorganisms. Analysis of 169 cases. Ann. Intern. Med. 60: 384, 1964. LinkGoogle Scholar16. STEINHAUEREICKHOFFKISLAKFINLAND BWTCJWM: The Klebsiella-Enterobacter-Serratia division: clinical and epidemiologic characteristics. Ann. Intern. Med. 65: 1180, 1966. LinkGoogle Scholar17. RONALDTURCK AM: Factors influencing in vitro susceptibility to the cephalosporins and clinical trial of an oral cephalosporin, cephaloglycin. Antimicrob. Agents Chemother. In press. Google Scholar18. JAYSHERRIS VCJC: Personal communication. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROGER J. BULGER, M.D.Affiliations: Seattle, WashingtonFrom the Department of Medicine, University of Washington School of Medicine, and the Veterans Administration Hospital, Seattle, Wash.This study was performed during the tenure of a Veterans Administration Clinical Investigatorship by Dr. Bulger.Requests for reprints should be addressed to Roger J. Bulger, M.D., Medical Director, University Hospital, Seattle, Wash. 98105. 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