tbuckley/cabot-search huggingface dataset:
Specific Immune of a Syngeneic Response Against Tumor-Associated Simian Virus 40-Induced Sarcoma in Antigens Mice
Authors: Moshe Glaser
Journal: JNCI Journal of the National Cancer Institute (1978)

Journal Article Specific Immune of a Syngeneic Response Against Tumor-Associated Simian Virus 40-Induced Sarcoma in Antigens Mice Get access Moshe Glaser Moshe Glaser 2Laboratory of Cell Biology. Immunology Program, Division of Cancer Biology and Diagnosis, National Cancer Institute, National Institutes of Health, Public Health Service, U.S. Department of Health, Education, and Welfare, Bethesda, Md. 20014. 3I thank Dr. L. W. Law for his interest and support during the course of this work, C. Altman for technical help, and L. Brunson for helping with the preparation of this manuscript. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 61, Issue 5, November 1978, Pages 1351–1355, https://doi.org/10.1093/jnci/61.5.1351 Published: 01 November 1978 Article history Received: 04 April 1978 Accepted: 03 July 1978 Published: 01 November 1978
Cell-mediated cytotoxicity for cultured autologous rheumatoid synovial membrane cells.
Authors: W A Neill
Journal: Annals of the Rheumatic Diseases (1980)

Cytotoxicity tests were performed on cultured rheumatoid synovial membrane cells with autologous lymphocytes as effector cells. Three of 26 cultures were positive when tested at primary or first passage level, but on subsequent tests became negative. Tests based on an isotope-labelling technique and a micro-cytotoxicity assay were compared; the results appeared to correlate well. The expression of neoantigens on synovial cells was not demonstrated. Cultures initiated in medium containing hydrocortisone did not give rise to a population of synovial cells susceptible to immune lysis by autologous lymphocytes.
Stinging insect hypersensitivity: A practice parameter update
Authors: John E. Moffitt, David B K Golden, Robert E. Reisman, Rufus Lee, Richard Nicklas, Theodore Freeman, Richard Deshazo, James Tracy, I. Leonard Bernstein, Joann Blessing-Moore, David A. Khan, David M. Lang, Jay M. Portnoy, Diane E. Schuller, Sheldon L. Spector, Steven A. Tilles
Journal: Journal of Allergy and Clinical Immunology (2004)
KAI1 COOH-Terminal Interacting Tetraspanin (KITENIN), a Member of the Tetraspanin Family, Interacts with KAI1, a Tumor Metastasis Suppressor, and Enhances Metastasis of Cancer
Authors: Ji Hee Lee, Sei Ryun Park, Kee-Oh Chay, Young-Woo Seo, Hyun Kook, Kyu Youn Ahn, Young Jin Kim, Kyung Keun Kim
Journal: Cancer Research (2004)

Abstract We cloned recently an alternatively spliced variant of KAI1 mRNA that lacked exon 7 at the COOH-terminal region and showed differences in metastasis suppression when compared with the wild-type KAI1. These findings indicated that the COOH-terminal region of KAI1 is critical for its metastasis suppressor function. In this study, we isolated a cDNA clone of VANGL1, a member of the tetraspanin protein family, which interacted specifically with the COOH-terminal cytoplasmic domain of KAI1 in the yeast two-hybrid system. We renamed it KAI1 COOH-terminal interacting tetraspanin (KITENIN). We found that KITENIN-overexpressing CT-26 mouse colon cancer cells showed increased tumorigenicity and early hepatic metastasis in vivo, as well as increased invasiveness and adhesion to fibronectin in vitro compared with parental cells. Moreover, increased levels of KITENIN were observed in a human gastric tumor and its metastatic tissues, compared with the normal adjacent mucosa. Our results indicate that KITENIN promotes adhesion and invasion of cancer cells in vitro and in vivo, and suggest that KITENIN participates in the regulation of the tumor formation and metastasis by interacting with KAI1, a metastasis suppressor and antisense KITENIN strategy that can be used to inhibit metastasis in various cancers.
Neurobehavioral Outcomes of School-age Children Born Extremely Low Birth Weight or Very Preterm in the 1990s
Authors: Peter Anderson
Journal: JAMA (2003)

The outcome into school age of regional cohorts of children born in the 1990s with birth weights less than 1000 g (extremely low birth weight, ELBW) or earlier than 28 weeks' gestation (very preterm) is not known.To determine the cognitive, educational, and behavioral outcome of ELBW or very preterm infants born in the 1990s compared with normal birth weight (NBW) controls.Regional cohort study.Victoria, Australia.The ELBW or very preterm cohort was composed of 298 consecutive survivors born during 1991-1992. The NBW cohort was composed of 262 randomly selected children with birth weights of more than 2499 g.Cognitive ability, educational progress, and behavioral problems.The follow-up rates from birth to 8 years of age for survivors were 92.3% (275/298) for the ELBW or very preterm cohort and 85.1% (223/262) for the NBW cohort. The ELBW or very preterm children scored significantly below NBW controls on full-scale IQ (mean difference, -9.4; 95% confidence interval [CI], -12.1 to -6.7; P<.001) and indices of verbal comprehension (mean difference, -6.8; 95% CI, -9.5 to -4.2; P<.001), perceptual organization (mean difference, -9.9; 95% CI, -12.7 to -7.2; P<.001), freedom from distractibility (mean difference, -8.1; 95% CI, -10.8 to -5.5; P<.001), and processing speed (mean difference, -6.7; 95% CI, -9.4 to -4.0; P<.001). The ELBW or very preterm children performed significantly worse than the NBW cohort on tests of reading (mean difference, -6.7; 95% CI, -9.5 to -3.9; P<.001), spelling (mean difference, -5.6; 95% CI, -8.0 to -3.3; P<.001), and arithmetic (mean difference, -8.8; 95% CI, -11.3 to -6.2; P<.001). Attentional difficulties, internalizing behavior problems, and immature adaptive skills were more prevalent in the ELBW or very preterm cohort.School-aged ELBW or very preterm children born in the 1990s continue to display cognitive, educational, and behavioral impairments.
The Homeobox Gene Lbx1 Specifies a Subpopulation of Cardiac Neural Crest Necessary for Normal Heart Development
Authors: Konstanze Schäfer, Petra Neuhaus, Julia Kruse, Thomas Braun
Journal: Circulation Research (2003)

Cardiac neural crest cells are known to play multiple roles during development of the inflow and outflow tract of the heart and the aortic arch. In addition, cardiac neural crest is required for normal heart tube looping and regulation of myocardial cell proliferation, as well as differentiation and function of the myocardium. We show that the homeobox gene Lbx1 is expressed in a subpopulation of the cardiac neural crest during tubular heart formation. Inactivation of the Lbx1 gene in mice resulted in defects in heart looping, changes in gene expression pattern, and increased cell proliferation ensuing in myocardial hyperplasia. We found that the activity of the Lbx1 promoter, as indicated by a LacZ reporter gene, is upregulated in the hearts of Lbx1 +/− :splotch 1H /splotch 1H and Lbx1 −/− mice, indicating that Pax3 and Lbx1 participate in a negative regulatory feedback that might be necessary for normal differentiation and function of the myocardium during early heart development. Because migration of Lbx1-expressing neural crest cells was not altered in Lbx1 −/− embryos, we postulate that Lbx1 gene function is critical for specification of a subpopulation of cardiac neural crest subsequent to migration.
Clinical, biochemical, and radiographic effects of aminohydroxypropylidene bisphosphonate treatment in rheumatoid arthritis.
Authors: S H Ralston, L Hacking, L Willocks, F Bruce, D A Pitkeathly
Journal: Annals of the Rheumatic Diseases (1989)

A placebo controlled, double blind study of aminohydroxypropylidene bisphosphonate (APD), given by monthly intravenous infusion, was conducted in 40 patients with rheumatoid arthritis. Biochemical markers of increased bone resorption, such as fasting urinary calcium/creatinine ratio and hydroxyproline/creatinine ratio, were suppressed significantly in the APD group to approximately 50% and 60% of the pretreatment level respectively, and serum calcium fell transiently after the first APD infusion. There was no significant effect on disease activity in either the APD or placebo groups as judged by clinical (grip strength, morning stiffness, visual analogue score) or laboratory (haemoglobin, platelet count, erythrocyte sedimentation rate, C reactive protein) criteria. An exception was the articular index which improved to a similar degree in both groups, falling from (mean (SEM] 13.8 (1.8) to 7.2 (2.2) in the APD group and from 13.7 (1.9) to 6.8 (1.5) in the placebo group. Radiological progression occurred to a similar degree in both groups as assessed by the Sharp index (mean (SEM) 86 (13.1) v 95 (12.9)-APD group; 103 (15.1) v 110 (15.8)-placebo group), but there was no significant change in the Larsen index in either group (mean (SEM) 53 (4.2) v 57 (3.8)-APD; 62 (5.8) v 63 (5.6)-placebo). The lack of effect on radiological progression in the APD group indicates that focal erosive disease may either have progressed as the result of a non-osteoclast related mechanism, or that the intensity of bone resorption was too great to be inhibited by the doses of APD used. The biochemical response to APD presumably reflected inhibition of bone resorption at other sites, suggesting that further studies of the effects of bisphosphates on periarticular and systemic osteoporosis in rheumatoid arthritis may be of the interest.
Disseminated linear calcinosis cutis associated with the Koebner phenomenon in an infant with congenital acute monocytic leukaemia
Authors: E.K. Satter, C.H. Maari, K.D. Morel, L.F. Eichenfield, B.B. Cunningham, S.F. Friedlander, J.N. Bergman
Journal: British Journal of Dermatology (2004)

Journal Article Disseminated linear calcinosis cutis associated with the Koebner phenomenon in an infant with congenital acute monocytic leukaemia Get access E.K. Satter, E.K. Satter Department of Paediatric Dermatology, Children's Hospital/University of California San Diego and Department of Dermatology, Naval Medical Center San Diego, San Diego, CA, U.S.A Elizabeth K.Satter. E‐mail: esatter@hotmail.com; JWSteger@nmcsd.med.navy.mil Search for other works by this author on: Oxford Academic Google Scholar C.H. Maari, C.H. Maari Department of Paediatric Dermatology, Children's Hospital/University of California San Diego and Department of Dermatology, Naval Medical Center San Diego, San Diego, CA, U.S.A Search for other works by this author on: Oxford Academic Google Scholar K.D. Morel, K.D. Morel Department of Paediatric Dermatology, Children's Hospital/University of California San Diego and Department of Dermatology, Naval Medical Center San Diego, San Diego, CA, U.S.A Search for other works by this author on: Oxford Academic Google Scholar L.F. Eichenfield, L.F. Eichenfield Department of Paediatric Dermatology, Children's Hospital/University of California San Diego and Department of Dermatology, Naval Medical Center San Diego, San Diego, CA, U.S.A Search for other works by this author on: Oxford Academic Google Scholar B.B. Cunningham, B.B. Cunningham Department of Paediatric Dermatology, Children's Hospital/University of California San Diego and Department of Dermatology, Naval Medical Center San Diego, San Diego, CA, U.S.A Search for other works by this author on: Oxford Academic Google Scholar S.F. Friedlander, S.F. Friedlander Department of Paediatric Dermatology, Children's Hospital/University of California San Diego and Department of Dermatology, Naval Medical Center San Diego, San Diego, CA, U.S.A Search for other works by this author on: Oxford Academic Google Scholar J.N. Bergman J.N. Bergman Department of Paediatric Dermatology, Children's Hospital/University of California San Diego and Department of Dermatology, Naval Medical Center San Diego, San Diego, CA, U.S.A Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 150, Issue 4, 1 April 2004, Pages 753–756, https://doi.org/10.1111/j.0007-0963.2004.05895.x Published: 01 April 2004 Article history Accepted: 01 September 2003 Published: 01 April 2004
Expression of Adhesion Molecules and G Proteins in Circulating Neutrophils in Chronic Obstructive Pulmonary Disease
Authors: AINA NOGUERA, XAVIER BUSQUETS, JAUME SAULEDA, JOSE  M. VILLAVERDE, WILLIAM MacNEE, ALVAR G. N. AGUSTÍ
Journal: American Journal of Respiratory and Critical Care Medicine (1998)

We investigated the expression of adhesion molecules in circulating neutrophils (lymphocyte function-associated antigen-1 [LFA-1], Mac-1, and L-selectin) and endothelial cells (soluble intercellular adhesion molecule-1[sICAM-1]) in 23 patients with stable chronic obstructive pulmonary disease (COPD), 18 subjects with exacerbated COPD, and 23 healthy volunteers. Also, in these circulating neutrophils, we assessed the expression of two G protein subunits (G α s and G α i1/2). Compared with control subjects, patients with stable COPD showed increased expression of Mac-1 (p < 0.001) and lower levels of sICAM-1 (p = 0.002); LFA-1 and L-selectin expression was similar in patients and control subjects. During exacerbations, compared with stable patients, the expression of Mac-1 and LFA-1 was reduced (p < 0.001). Finally, the expression of G α s (but not G α i1/2) was also reduced (p < 0.001) in circulating neutrophils of patients with COPD, irrespective of the clinical condition of the patient. These results indicate that in patients with COPD: (1) the expression of some neutrophil adhesion molecules (Mac-1) is abnormal, and that this pattern changes during exacerbations; (2) there may be a form of endothelial dysfunction, as suggested by the low sICAM-1 levels; (3) the expression of G protein subunit (G α s) in circulating neutrophils is downregulated, irrespective of their clinical conditions. Overall, these results indicate the presence of significant systemic abnormalities in COPD.
Clinical picture of the amyloid arthropathy in patients with chronic renal failure maintained on haemodialysis using cellulose membranes.
Authors: J Munoz-Gomez, R Gomez-Perez, E Llopart-Buisan, M Sole-Arques
Journal: Annals of the Rheumatic Diseases (1987)

The clinical picture of 15 patients (10 male, five female) with amyloid arthropathy secondary to chronic renal failure treated with haemodialysis has been studied. The average period of haemodialysis was 10.8 years. Joint symptoms appeared between three and 13 years after starting haemodialysis. No patient had renal amyloidosis. Early symptoms were varied and often overlapped: knee swelling (seven patients), painful and stiff shoulders (seven), and carpal tunnel syndrome (six) were the most prominent. Follow up showed extension to other joints. Joint effusions were generally of the non-inflammatory type. Radiologically, geodes and erosions of variable sizes were seen in the affected joints, which can develop into a destructive arthropathy. Amyloid was found in abdominal fat in three of the 12 patients on whom a needle aspiration was performed. Four of 12 patients showed changes compatible with amyloid infiltration in the echocardiogram. One patient had amyloid in the gastric muscular layer, another in the colon mucus, and two of four in rectal biopsy specimens. Amyloid deposits showed the presence of beta 2 microglobulin in 10 patients. The clinical and radiological picture was similar to the amyloid arthropathy associated with multiple myeloma. These patients can develop systemic amyloidosis.
Dyskinesias following neural transplantation in Parkinson's disease
Authors: Peter Hagell, Paola Piccini, Anders Björklund, Patrik Brundin, Stig Rehncrona, Håkan Widner, Lesley Crabb, Nicola Pavese, Wolfgang H. Oertel, Niall Quinn, David J. Brooks, Olle Lindvall
Journal: Nature Neuroscience (2002)
Double blind controlled trial of oral vancomycin as adjunctive treatment in acute exacerbations of idiopathic colitis.
Authors: R J Dickinson, H J O'Connor, I Pinder, I Hamilton, D Johnston, A T Axon
Journal: Gut (1985)

A prospective double blind trial of vancomycin vs placebo was undertaken in 40 consecutive adult patients with exacerbation of idiopathic colitis (33 ulcerative colitis, seven Crohn's disease). Vancomycin or placebo (500 mg six hourly) was given for seven days in addition to routine medical therapy. Although there was no significant overall difference in outcome between the two groups, there was a trend towards a reduction in the need for operative intervention in patients with ulcerative colitis treated with vancomycin compared with controls. The efficacy of vancomycin was not attributable to its known action against C difficile, which was not isolated from any of the patients. The data suggest that microbiological factors may play a part in the pathogenesis of ulcerative colitis and that further studies using antimicrobials are desirable.
DRUG-INDUCED HAEMOLYTIC ANAEMIA IN DERMATITIS HERPETIFORMIS..
Authors: H. E. HUTCHISON, J. M. JACKSON, PATRICIA CASSIDY
Journal: British Journal of Dermatology (1963)

Journal Article DRUG‐INDUCED HAEMOLYTIC ANAEMIA IN DERMATITIS HERPETIFORMIS.: The Importance of Heinz Bodies in its Recognition. Get access H. E. HUTCHISON, M.D., F.R.F.P.S.G., H. E. HUTCHISON, M.D., F.R.F.P.S.G. Reader Department of Haematology, The University and Western Infirmary, Glasgow Search for other works by this author on: Oxford Academic Google Scholar J. M. JACKSON, B.Sc, M.B., Ch.B., J. M. JACKSON, B.Sc, M.B., Ch.B. Registrar Department of Haematology, The University and Western Infirmary, Glasgow Search for other works by this author on: Oxford Academic Google Scholar PATRICIA CASSIDY, B.Sc PATRICIA CASSIDY, B.Sc Scientific Officer Department of Haematology, The University and Western Infirmary, Glasgow Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 75, Issue 4, 1 April 1963, Pages 161–166, https://doi.org/10.1111/j.1365-2133.1963.tb13960.x Published: 01 April 1963
Murine Gammaherpesvirus 68 Infection of IFNγ Unresponsive Mice: A Small Animal Model for Gammaherpesvirus-Associated B-Cell Lymphoproliferative Disease
Authors: Katherine S. Lee, Steve D. Groshong, Carlyne D. Cool, Bette K. Kleinschmidt-DeMasters, Linda F. van Dyk
Journal: Cancer Research (2009)

Gammaherpesviruses are tightly controlled by the host immune response, with gammaherpesvirus-associated malignancies prevalent in immune-suppressed individuals. Previously, infection of IFNgamma-unresponsive mice with gammaherpesvirus 68 (gammaHV68) showed that IFNgamma controlled chronic infection, limiting chronic diseases including arteritis and pulmonary fibrosis. Here, we show that gammaHV68-infected IFNgamma receptor-deficient (IFNgammaR(-/-)) mice uniformly develop angiocentric inflammatory lesions in the lung. Prolonged infection revealed a range of outcomes, from spontaneous regression to pulmonary lymphoma. By 12 months of infection, 80% of mice had lymphoid hyperplasia or pulmonary lymphoma; 45% of infected mice developed frank tumors between 5 and 12 months postinfection, with some mice showing systemic involvement. Lymphomas were composed of B lymphocytes and contained latently infected cells. Although IFNgammaR(-/-) mice control chronic gammaHV68 infection poorly, both early and late pathologies were indistinguishable between wild-type and reactivation-defective virus infection, indicating that, in contrast with other previously described gammaHV68-associated pathologies, these chronic diseases were not dependent on the reactivation of latent infection. This distinct combination of latent infection and defined host defect led to a specific and consistent lymphoproliferative disease. Significantly, this mouse model of virus-associated pulmonary B-cell lymphoma closely mimics the full spectrum of human lymphomatoid granulomatosis, an EBV-associated malignancy with no effective treatment.
Hemorrhagic and Serous-Filled Vesicles and Bullae—Quiz Case
Authors: Lindsey B. Finklea, Larry E. Becker
Journal: JAMA Dermatology (2013)

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Clinical implications of uterine malformations and hysteroscopic treatment results
Authors: Grigoris F. Grimbizis, Michel Camus, Basil C. Tarlatzis, John N. Bontis, Paul Devroey
Journal: Human Reproduction Update (2001)

Uterine malformations consist of a group of miscellaneous congenital anomalies of the female genital system. Their mean prevalence in the general population and in the population of fertile women is ∼4.3%, in infertile patients ∼3.5% and in patients with recurrent pregnancy losses ∼13%. Septate uterus is the commonest uterine anomaly with a mean incidence of ∼35% followed by bicornuate uterus (∼25%) and arcuate uterus (∼20%). It seems that malformed uterus and especially septate uterus is not an infertility factor in itself. However, it may have a part in the delayed natural conception of women with mainly secondary infertility. On the other hand, patients with uterine malformations seem to have an impaired pregnancy outcome even as early as their first pregnancy. Overall term delivery rates in patients with untreated uterine malformations are only ∼50% and obstetric complications are more frequent. Unicornuate and didelphys uterus have term delivery rates of ∼45%, and the pregnancy outcome of patients with untreated bicornuate and septate uterus is also poor with term delivery rates of only ∼40%. Arcuate uterus is associated with a slightly better but still impaired pregnancy outcome with term delivery rates of ∼65%. Women who have undergone hysteroscopic septum resection and have been reported in the different series comprise a highly selected group of symptomatic patients with term delivery and live birth rates of only ∼5%. Hysteroscopic treatment seems to restore an almost normal prognosis for the outcome of their pregnancies with term delivery rates of ∼75% and live birth rates of ∼85%. It seems, therefore, that hysteroscopic septum resection can be applied as a therapeutic procedure in cases of symptomatic patients but also as a prophylactic procedure in asymptomatic patients in order to improve their chances for a successful delivery.