tbuckley/cabot-search huggingface dataset:
Abstract 294: Sox2 remodels the tumor microenvironment via recruitment of Tregs
Authors: Yingxi Xu, Wenjun Mou, Yanan Chen, Lina Wang, Rong Xiang, Na Li
Journal: Cancer Research (2012)

Abstract Recent study showed that Sox2 gene, a key stem cell gene that maintains the pluripotency properties of embryonic stem cell (ESC) and cancer stem cell (CSC) plays an important role in the tumorigenesis and metastasis process of various types of tumor, however its regulatory effect on tumor microenvironment (TME) is still elusive. In this study, we established a BALB/c mice model xenografted with a mice breast cancer cell line-4T1 with down-regulation of Sox2 gene (4T1-shRNA-Sox2). We found that down-regulation of Sox2 inhibits the growth of tumors with a modulated immunomicroenvironment, which was reflected by the increased number of CD3+CD8+ T cells and expression level of Th1 cytokines, such as TFN-γ and decreased number of Foxp3+ Tregs and expression level of Th2 cytokines such as IL4, IL6 and IL10. In addition, the reduced expression level of vascular endothelial cell marker CD31 and lymphatic vessel marker Lyve-1 was also revealed in the 4T1-shRNA-Sox2 xenografted tumors. We further demonstrated that Sox2 modulates the TME by recruiting Tregs. By using real-time RT-PCR, we found the cytokines contributing to recruitment of Tregs, such as CCL1, CCL22, CCL28 and Cxcl12 reduced after Sox2 downregulation. In addition, the mRNA expression level of transcriptional factor NF-κB and its co-transcriptional factor RelA which controlled the expression of CCL1, CCL22 and CCL28 were also reduced. Consequently, our study revealed the functional interaction between tumor cells and the immunocytes in TME by demonstrated that Sox2 gene in tumor cells recruited Tregs to influence the tumor microenvironment thus promotes the growth of tumor. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 294. doi:1538-7445.AM2012-294
THE SURGICAL TREATMENT OF ARTERIAL EMBOLISM
Authors: ARTHUR A. ZIEROLD
Journal: JAMA (1933)

The history of the surgical treatment of arterial embolism is a comparatively short one. This is somewhat difficult to explain in view of the fact that the principles of vascular surgery have been developing since the time of John Hunter. The first surgeon of record to attempt to remove an embolus by arteriotomy was Ssabanejew.<sup>1</sup>In 1895, because of the impending gangrene of a leg, he opened the femoral artery and endeavored to remove the embolus. He was not successful, and after amputation of the leg the patient died. The first completely successful operation was performed by Labey<sup>2</sup>in 1911, when he removed an embolus from the femoral artery six hours after the occurrence of symptoms. The chronology of attempt and success is detailed at length in the article which Einar Key<sup>3</sup>wrote in 1921. At this time, Key reported the first series of importance, and it
Total Anomalous Pulmonary Return
Authors: VINCENT L. GOTT, RICHARD G. LESTER, C. WALTON LILLEHEI, RICHARD L. VARCO
Journal: Circulation (1956)

Thirty cases of total anomalous pulmonary return have been collected and analyzed. The pathways of drainage and their embryologic development are discussed. The cardiac catheterization, electrocardiographic and radiologic findings are also presented. These laboratory data accompanied by the clinical findings seem to identify a recognizable diagnostic picture for this malformation. Finally, our attempts at surgical correction of this defect are briefly enumerated.
Syndrome of Rochalimaea henselae Adenitis Suggesting Cat Scratch Disease
Authors: Matthew J. Dolan
Journal: Annals of Internal Medicine (1993)

Objective: To describe a clinical syndrome of cat scratch disease caused by Rochalimaea henselae, including methods for isolation of the organism from tissue and for identification. Design: Case series. Setting: U.S. Air Force referral hospital infectious diseases clinic. Patients: Two previously healthy patients. Main Measurements and Results: Two immunocompetent patients who had handled cats developed unilateral upper-extremity adenitis associated with a distal papular lesion and fever. The adenitis and distal lesions persisted and progressively worsened. Cultures of the involved lymph nodes from both patients grew R. henselae, a recently described organism associated with bacillary angiomatosis and peliosis hepatis in human immunodeficiency virus-infected patients and with bacteremia in immunocompromised and immunocompetent hosts. The organism was characterized as oxidase negative and X-factor dependent and had a characteristic pattern in analysis of whole-cell fatty acids differing from Afipia felis, a bacterium that has been associated with cat scratch disease. The identity of the isolate was confirmed by analysis of whole-cell fatty acids using gas chromatography and by amplification of the citrate synthetase gene sequence and analysis of the polymerase chain reaction-amplified product. The organisms were broadly susceptible to a variety of antimicrobials by broth microdilution; however in vitro resistance to first-generation cephalosporins correlated with clinical failure of therapy. Conclusion: Rochalimaea henselae can be a cause of cat scratch disease in immunocompetent patients.
Abstract 4385: PD-1 blockade enhances T-cell migration to tumor through induction of IFN-γ inducible chemokines
Authors: Weiyi Peng, Chenwen Liu, Chunyu Xu, Jieqin Chen, Yanyan Lou, Willem Overwijk, Gregory Lizée, Hideo Yagita, Patrick Hwu
Journal: Cancer Research (2012)

Abstract Adoptive cell transfer (ACT) is a promising therapeutic modality for cancer. Although tumor regression can be dramatic in some ACT-treated patients, other patients do not experience any clinical response, underscoring the need for further improvements. One limiting factor in ACT is immune suppression within the tumor microenvironment. In this study, we used a murine ACT model by treating gp100-expressing tumor-bearing mice with transgenic Pmel T-cells, which recognize gp100 in the context of H-2Db. We demonstrated that the expression of programmed death 1(PD-1) on transferred Pmel T-cells was upregulated at the tumor site, compared with transferred T cells in the spleen (48.07% vs 4.87% respectively). Given that PD-1 has been shown to attenuate T-cell mediated antitumor immune responses, we tested whether blockade of the PD-1 pathway by anti-PD-1 antibody could enhance the antitumor activity of adoptively transferred T-cells. We found that tumor-bearing mice treated with a combination of anti-PD-1 and ACT showed enhanced tumor regression compared to mice treated with ACT alone (median tumor size 11.30± 1.89 vs 43.85±7.28 mm2 on day 24 after tumor inoculation, respectively, p &amp;lt;0.001). We also observed increased accumulation of transferred Pmel T cells in the tumor sites of mice receiving combination therapy with ACT and anti-PD-1 using bioluminescence imaging compared to ACT alone (Median luciferase output of 6.5X106 vs 1.6X106 photons/s/cm2/sr, respectively on day 6 after T-cell transfer, p value =0.039). Although anti-PD-1 did not alter the number of immunosuppressive Treg cells and MDSCs, anti-PD-1 treatment did increase the expression of IFN-γ and the IFN-γ inducible chemokine, CXCL10, at the tumor site. Using flow cytometry to analyze the CXCL10 production in the tumor microenvironment, we found that most of the CXCL10-secreting cells were CD11b+ cells, indicating that myeloid cells are the major CXCL10-producing population. Furthermore, bone marrow chimera experiments with IFN-γR-/- mice implicated IFN-γ as a major nexus point for controlling PD-1 blockade-induced tumor infiltration by T cells. Taken together, our results imply that therapeutic blockade of the PD-1 pathway may trigger a positive feedback loop by increasing IFN-γ presence at the tumor site, which in turn induces chemokine-dependent trafficking of more immune cells to metastatic sites. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4385. doi:1538-7445.AM2012-4385
Large outbreak of food poisoning caused by Salmonella typhimurium definitive type 49 in mayonnaise.
Authors: E. Mitchell, M. O'Mahony, D. Lynch, L. R. Ward, B. Rowe, A. Uttley, T. Rogers, D. G. Cunningham, R. Watson
Journal: BMJ (1989)

An investigation was conducted to determine the vehicle of infection of an outbreak of food poisoning in a large metropolitan building early in 1988. A questionnaire was distributed to 700 people who had eaten in the building during the week of the outbreak, and attack rates for specific food were calculated. Food and stool samples, environmental samples, and eggs and environmental swabs from the egg suppliers were examined microbiologically. Altogether 474 questionnaires were returned, 120 people reporting gastrointestinal illness. The illness was significantly associated with foods containing mayonnaise. Salmonella typhimurium definitive type 49 was isolated from 76 of the 84 stool samples containing salmonella and from five of the eight samples taken from the chicken house of the main egg supplier. Mayonnaise was probably the vehicle of infection, which was caused by S typhimurium definitive type 49.
Thromboembolic complications of cancer: Epidemiology, pathogenesis, diagnosis, and treatment
Authors: Douglas E. Sutherland, Ilene C. Weitz, Howard A. Liebman
Journal: American Journal of Hematology (2002)

Abstract The association between malignancy and clinical thrombosis has been recognized for nearly 140 years. The purpose of this review is to examine our current understanding of thrombosis as a complication of cancer and cancer therapy. The review includes a discussion of the epidemiology, pathophysiology, diagnosis and treatment. Am. J. Hematol. 72:43–52, 2003. © 2002 Wiley‐Liss, Inc.
Two Cases of Tetanus Neonatorum
Authors: C. A. St. Hill, H. Lederer
Journal: BMJ (1948)

in Russia.He was employed as an egg-tester at the London docks, and two weeks before the onset of his illness had been dealing with a cargo of eggs arriving by ship from Poland-a journey which took seven days.He was quite definite that he had never had any louse infestation, but did admit to being bitten frequently by fleas while at work.The Ministry of Health intended to carry out a rickettsial survey of the rats in the docks, but could find no rats in that area.
Vesicles and Targetoid Lesions in a Postpartum Woman
Authors: Pamela A. Morganroth, Chauncey A. McHargue
Journal: JAMA Dermatology (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Identification of soybean allergens with sera from subjects having a positive DBPCFC or history of anaphylaxis to soy
Authors: T. Holzhauser, B. Ballmer-Weber, C. Bindslev-Jensen, J. Scibilia, G. Zisa, C. Ortolani, D. Mittag, O. Petrovskaya, S. Utsumi, R. Goodman, S. Vieths
Journal: Journal of Allergy and Clinical Immunology (2005)
P3-16-13: Cardiac Safety of Non-Pegylated Liposomal Doxorubicin and Docetaxel as 1st Line Treatment in Metastatic HER2 Negative Breast Cancer (Myotax Study).
Authors: Warmerdam L van, P Schiphorst, P Nieboer, M Dercksen, Jongh F de, R Schmidt
Journal: Cancer Research (2011)

Abstract Background: Doxorubicin (DOX) is an effective, but cardiotoxic agent in metastatic breast cancer (BC). Incidence of heart failure (HF) is 2–4% and increases considerably with cumulative doses over 450–550 mg/m2. In Myocet® DOX is encapsulated in liposomes. It is delivered predominantly to areas with increased capillary permeability such as tumors and reduces cardiac exposure. We conducted an open non-comparative study to assess cardiac safety of Myocet® combined with docetaxel. Materials and methods: Females with locally advanced or metastatic HER2 negative BC. 6 cycles of Myocet® 60 mg/m2 and docetaxel 75 mg/m2 q3w as 1st line therapy. Left ventricular ejection fraction (LVEF) and disease status were assessed after cycle 2,4 and 6. Primary endpoint: signs and symptoms of HF (NYHA III-IV) or LVEF &amp;lt;50% and decrease ≥5% (with symptoms) or ≥10% (without symptoms). Results: 68 patients (pats) were included. Mean (sd;range) age 56,3 y (10,2;32-79), mean disease duration 5,5 y (5,1 y;1 mo-19 y), 31 pats had anthracyclines (AN) in the past. 49 pats completed all 6 cycles. Mean LVEF (%) over time are presented in table 1. 4 pats (3 AN pretreated) met the LVEF criteria for cardiotoxicity (no signs/symptoms of HF) after the 6th cycle. In 3 pats (all AN pretreated) a significant drop in LVEF was given as (one of the) reason(s) for premature discontinuation, but LVEF criteria for cardiotoxicity were not met. 73 grade ≥3 toxicities occurred in 32 pats; most frequent: neutropenia (±fever) 19 pats. Premature discontinuations (no. of pats): progressive disease 9, cardiotoxicity 3, other toxicity 4, death 2, other reason 1. In 10 pats the dose of Myocet was reduced. The best response was scored for 50 pats with at least 1 measurable lesion: CR 4, PR 28, SD 14, PD 4. Mean LVEF in the entire group decreased during the study from 63 to 59 (9,2) %. The decrease in the AN pretreated group was 7% and in the not pretreated pats 3%. 4 pats met the LVEF criteria for cardiotoxicity and 3 others were withdrawn for cardiotoxicity without meeting the criteria. 6 of these pats were AN pretreated. None of them had signs/symptoms of HF. PR or better was observed in 64% of pats. Conclusion: Liposomal DOX might provide more cardiac safety compared to conventional AN, but pats pretreated with conventional AN seem to be more prone to LVEF decrease. No signs or symptoms of HF have been observed. The combination of Myocet® and docetaxel is efficacious and sufficiently well tolerated and is currently investigated in combination with trastuzumab in HER2 positive pats. Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr P3-16-13.
Amyotrophic Lateral Sclerosis and Spinocerebellar Ataxia Type 2 in a Family With Full CAG Repeat Expansions of<i>ATXN2</i>
Authors: Sirinan Tazen, Karla Figueroa, Justin Y. Kwan, Jill Goldman, Ann Hunt, Jacinda Sampson, Laurie Gutmann, Stefan M. Pulst, Hiroshi Mitsumoto, Sheng-Han Kuo
Journal: JAMA Neurology (2013)

A family with coexistence of spinocerebellar ataxia type 2 and amyotrophic lateral sclerosis (ALS) is described.Intermediate or full CAG repeat expansions of ATXN2 are associated with ALS. However, no coexistence of spinocerebellar ataxia type 2 and ALS in a family has been reported in the literature.We describe a 47-year-old woman with an 11-year history of ataxia and her paternal uncle with ALS who were evaluated at Columbia University Medical Center since July 2006. Both our patient with ataxia and her uncle with ALS have full pathological CAG repeat expansions of ATXN2.The diverse clinical phenotypes of ATXN2 CAG expansions and their coexistence in a single family are highlighted. A clinician should consider the diagnosis of spinocerebellar ataxia type 2 when encountering a patient with ataxia and a family history of ALS.
"WHO'S WHO IN AMERICAN MEDICINE"
Authors: F. J. Walter
Journal: JAMA (1926)

To the Editor:  —About a year ago I was circularized re Who's Who in American Medicine. Without much thought I filled in the blank as one would the questionnaire of the A. M. A. Directory, and later canceled the order. I now realize the folly of such a publication coming from a commercial publishing company. The publishers insisted on mailing a copy, which I refused at the post-office. Since then I have had two bills and several letters insisting that I must take the book on moral grounds.  There is no need of such a publication that cannot be better filled by our own directory. I ask, How is any one to judge who is who anyway? What special talent is to decide?
HEMATOMA OF VULVA DURING LABOR
Authors: C. E. MOORE
Journal: JAMA (1910)

<h3>History.—</h3> Mrs. F., primipara, had been in labor about four hours, dilatation of the cervix had progressed normally and she was in second stage with everything pointing to a speedy delivery. The pains were rather hard, accompanied by a great tendency to bear down, so I had commenced to give chloroform with each pain. About ten minutes after my last examination, she began to complain of a sharp cutting pain in the right labium. On examination I found a tumor about the size of an orange. In pressing my hand over it to determine whether or not it was a hernia, I noticed at once that it was rapidly enlarging. <h3>Treatment.—</h3> Recognizing what I had to deal with, I pushed the chloroform and had the nurses prepare things for opening and stopping the hemorrhage, which had now reached the size of a child's head, and had, indeed, very much the
Differences in Sleep Disturbance Parameters Between Oncology Outpatients and Their Family Caregivers
Authors: Sara Carney, Theresa Koetters, Maria Cho, Claudia West, Steven M. Paul, Laura Dunn, Bradley E. Aouizerat, Marylin Dodd, Bruce Cooper, Kathryn Lee, William Wara, Patrick Swift, Christine Miaskowski
Journal: Journal of Clinical Oncology (2011)

This study compared the occurrence rates for and severity ratings of sleep disturbance in patient-family caregiver (FC) dyads.
Chromaffin Reacting Cells in Human Digital Skin
Authors: G. E. BURCH, J. H. PHILLIPS
Journal: Circulation Research (1958)

These studies demonstrated the existence of chromaffin-reacting granules in the human skin. The chromaffin reaction was provided by bichromate fixation. Subsequent special staining by the modified Sevki procedure revealed these granules to be localized usually to characteristic long, eel-like cells with distinctive tinctorial features. Although the true significance of these cells is not certain, they are believed to represent the local source of a vasopressor material for the peripheral tissues. Much indirect physiologic evidence supports this belief.
Hemodynamic Studies in Rheumatic Heart Disease
Authors: M. IRENÉ FERRER, RÉJANE M. HARVEY, RICHARD T. CATHCART, ANDRÉ COURNAND, DICKINSON W. RICHARDS
Journal: Circulation (1952)

Hemodynamic studies were made in 42 patients with rheumatic heart disease with various valvular lesions and in different stages of cardiac function. These studies include observations not only at rest, but also during exercise, following the acute administration of Digoxin, and after recovery from failure. The relationship between symptomatology and hemodynamic findings were considered and the importance of differentiating between mechanical block and left ventricular myocardial failure as causes for pulmonary artery hypertension is stressed.
The effect of intracutaneous injections of micronized crystalline suspensions of nandrolone phenylpropionate in the skin of female hairless hamsters
Authors: M.A. CLARK, W. PICTON
Journal: British Journal of Dermatology (1977)

Single intracutaneous injections of micronized crystalline suspensions of nandrolone phenylpro-pionate have been shown to induce local thickening of the epidermis of female hairless hamsters, accompanied by a marked increase in sebaceous gland volume over a period of 7 days. It is known that certain materials, when injected intracutaneously, may produce a diffuse inflammatory response in the dermis which in turn causes hyperplasia in the adjacent epidermis. The response observed in the present case, however, is clearly specific to nandrolone phenylpropionate, and cannot be attributed to an inflammatory response of the dermis to intracutaneously injected crystalline material.
Subclinical Neuropathy in Lead Workers
Authors: M. J. Catton, M. J. G. Harrison, P. M. Fullerton, G. Kazantzis
Journal: BMJ (1970)

Evidence is presented for a minimal defect of peripheral nerve function in a group of lead accumulator workers without clinical evidence of a neurological lesion. Of the 19 men examined, 13 had blood levels above 80 mug./100 ml. and seven had haemoglobin levels below 12 g./100 ml., showing that considerable exposure to lead was occurring.
TRAINING FOR CHILDBIRTH
Authors: HERBERT THOMS
Journal: JAMA (1949)

In the foreword to Helen Heardman's recent book, "A Way to Natural Childbirth," Dr. F. J. Browne, professor of obstetrics at the University of London, writes: "Nothing has been more remarkable in the practice of obstetrics within the last ten years than the increasing appreciation of the value of principles enunciated by Edmund Jacobson in 1929 in his book 'Progressive Relaxation' and afterwards applied to midwifery by Grantly Dick Read in his two books, 'Natural Childbirth' and 'Revelations of Childbirth.' " In considering the recommendations of those who advocate the use of procedures aimed at physiologic, or "natural," childbirth one should understand that the technics suggested are concerned with more than parturition itself. In its broad application it represents an attempt on the part of those who care for pregnant and parturient women to gain further understanding of the physiology of pregnancy and labor, including its emotional aspects, so that these
CD52 expression in hairy cell leukemia
Authors: Michael M. Quigley, Kelly J. Bethel, Robert W. Sharpe, Alan Saven
Journal: American Journal of Hematology (2003)

Hairy cell leukemia (HCL) is a rare chronic B-cell lymphoproliferative disorder characterized by splenomegaly, pancytopenia, and circulating atypical lymphocytes with circumferential cytoplasmic projections. Although uncommon, HCL cases refractory to standard therapy occur, and effective alternatives are limited. There is evolving literature supporting monoclonal antibody therapy in the treatment of B-cell lymphoid malignancies, including anti-CD52 (Campath-1H, alemtuzumab). We have examined nine cases of HCL and one case of HCL variant by flow cytometry for CD52 expression. All cases expressed CD52 antigen in 92-100% of the malignant cells. The demonstration of CD52 antigen expression on HCL cells provides the rationale for the use of alemtuzumab in refractory HCL.
Immunotherapy of renal cell carcinoma
Authors: G. P. Haas, G. G. Hillman, B. G. Redman, J. E. Pontes
Journal: CA A Cancer Journal for Clinicians (1993)

Immunologic approaches to the therapy of metastatic renal cell carcinoma have provided moderate improvement in response rates for a disease that is extremely resistant to all forms of treatment. This article reviews recent clinical efforts using immunotherapy for renal cell carcinoma, including the adoptive transfer of cytotoxic killer cells and/or the use of biologic response modifiers, such as interferon and interleukin-2.