Cystatin C, Renal Function, and Cardiovascular Risk
Authors: Pierre Delanaye, Etienne Cavalier, Jean-Marie Krzesinski
Journal: Annals of Internal Medicine (2008)

Letters19 February 2008Cystatin C, Renal Function, and Cardiovascular RiskPierre Delanaye, MD, Etienne Cavalier, MD, and Jean-Marie Krzesinski, MD, PhDPierre Delanaye, MDFrom University of Liège, CHU Sart Tilman, B-9000 Liège, Belgium., Etienne Cavalier, MDFrom University of Liège, CHU Sart Tilman, B-9000 Liège, Belgium., and Jean-Marie Krzesinski, MD, PhDFrom University of Liège, CHU Sart Tilman, B-9000 Liège, Belgium.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-148-4-200802190-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We read with interest the article by Menon and colleagues (1) concerning cystatin C as a cardiovascular risk factor. We believe their paper considerably increases the quality of articles published on this topic, especially because glomerular filtration rate (GFR) was measured with a reference method.We have some comments. First, it is important to keep in mind that this study analyzes cystatin C as a cardiovascular risk factor. Because all the patients had chronic kidney disease (CKD) (GFR <55 mL/min per 1.73 m2), this study cannot be used to assert that cystatin C is definitively better than ...References1. Menon V, Shlipak MG, Wang X, Coresh J, Greene T, Stevens L, et al. Cystatin C as a risk factor for outcomes in chronic kidney disease. Ann Intern Med. 2007;147:19-27. [PMID: 17606957] LinkGoogle Scholar2. Macdonald J, Marcora S, Jibani M, Roberts G, Kumwenda M, Glover R, et al. GFR estimation using cystatin C is not independent of body composition. Am J Kidney Dis. 2006;48:712-9. [PMID: 17059990] CrossrefMedlineGoogle Scholar3. Rule AD, Bergstralh EJ, Slezak JM, Bergert J, Larson TS. Glomerular filtration rate estimated by cystatin C among different clinical presentations. Kidney Int. 2006;69:399-405. [PMID: 16408133] CrossrefMedlineGoogle Scholar4. Singer MA. Of mice and men and elephants: metabolic rate sets glomerular filtration rate. Am J Kidney Dis. 2001;37:164-178. [PMID: 11136185] CrossrefMedlineGoogle Scholar5. Speakman JR. Body size, energy metabolism and lifespan. J Exp Biol. 2005;208:1717-30. [PMID: 15855403] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From University of Liège, CHU Sart Tilman, B-9000 Liège, Belgium.Acknowledgment: The author thanks Dr. Jamie Macdonald for his help in the redaction of the manuscript.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoCystatin C as a Risk Factor for Outcomes in Chronic Kidney Disease Vandana Menon , Michael G. Shlipak , Xuelei Wang , Josef Coresh , Tom Greene , Lesley Stevens , John W. Kusek , Gerald J. Beck , Allan J. Collins , Andrew S. Levey , and Mark J. Sarnak Cystatin C, Renal Function, and Cardiovascular Risk Vandana Menon , Mark J. Sarnak , and Michael G. Shlipak Metrics 19 February 2008Volume 148, Issue 4Page: 323KeywordsAttentionCellsChronic kidney diseaseConflicts of interestCreatinineGlomerular filtration rateHyperthyroidismMedical risk factorsMusclesRenal diseases ePublished: 19 February 2008 Issue Published: 19 February 2008 CopyrightCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...