tbuckley/cabot-search huggingface dataset:
Recurrence of Coccidioidal Meningitis After Discontinuation of Fluconazole
Authors: Sarah Nelson, Michal Vytopil
Journal: JAMA Neurology (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
West Virginia Society in Line.
Authors: Wm. W. Golden
Journal: JAMA (1902)

Elkins, W. Va., July 14, 1902. <h3>To the Editor:</h3> —In enumerating in your last two issues the states which have adopted constitutions and by-laws patterned after those proposed by the American Medical Association you have omitted to include among them the State of West Virginia. Fraternally yours, <h3>Note.</h3> —InThe Journalof June 14, 1902, page 1590, we credited West Virginia with adopting "by unanimous vote" a constitution and by-laws "in entire conformity" with the plan of the American Medical Association, and we regret to have omitted the state in the editorials to which Dr. Golden refers. West Virginia is in line.
Aspiration of a Dental Appliance in a Patient With Alzheimer Disease
Authors: John S. Oghalai
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Cervical Spine
Authors: Leonard F. Peltier
Journal: JAMA (1984)

This book is the joint effort of a committee of the Cervical Spine Research Society, a multidisciplinary, international group of physicians with a special interest in the cervical spine. The 53 contributors to the book reflect the composition of the society, and each is an expert in the area of his contribution. The book, organized into 13 chapters, concisely and clearly presents the current state of knowledge and opinion regarding the diagnosis and treatment of injuries and diseases of the cervical spine.  The anatomy of the cervical spine is well presented from the viewpoints of embryology, normal anatomy, and the congenital anomalies. The section on biomechanics is excellent, particularly in the discussion of instability. The radiographic diagnosis of injuries and diseases is thorough and considers not only standard methods, but also computed tomography, myelography, isotopic scanning, and arteriography. The basics of the neurological examination and evaluation are well presented.  The
The effect of atrial natriuretic factor on blood pressure, heart rate, and renal functions in conscious, spontaneously hypertensive rats.
Authors: M Gellai, R E DeWolf, L B Kinter, R Beeuwkes
Journal: Circulation Research (1986)

Atrial natriuretic factors, polypeptides released by atrial myocytes, may play a role in the control of blood pressure and the regulation of renal salt and water excretion. Our studies were designed to assess the role of a synthetic peptide, atriopeptin II, on blood pressure and heart rate, renal hemodynamics, and salt and water excretion in conscious, spontaneously hypertensive rats and in normotensive Wistar-Kyoto rats. Changes in mean arterial pressure and heart rate were recorded following intravenous bolus injections (0.1, 1.0, 10, 100 micrograms/kg) of atriopeptin II in 5 spontaneously hypertensive and 5 Wistar-Kyoto rats. In a second group of rats the peptide was infused for 90 minutes in two different doses: low dose, 1 microgram/kg + 2 micrograms/kg/hr; and high dose, 10 micrograms/kg + 20 micrograms/kg/hr. Bolus injections of atriopeptin II resulted in dose-dependent decreases in mean arterial pressure in the hypertensive, but not in the normotensive, rats; heart rates remained unchanged. Blood pressure decreased gradually during the sustained infusion of both doses of atriopeptin II, with the spontaneously hypertensive strain showing increased sensitivity compared to the Wistar-Kyoto strain. Heart rate decreased in both strains during infusion of the high dose; the decrease was significant only in the hypertensive rats. The low dose of atriopeptin II increased the clearance of free water in both strains of rats; sodium excretion was increased only in the hypertensive rats. The high-dose atriopeptin II was associated with transient natriuresis, unaltered glomerular filtration rate, and decreased effective renal blood flow in both strains.(ABSTRACT TRUNCATED AT 250 WORDS)
Specific inhibition of hepatitis C viral gene expression by antisense phosphorothioate oligodeoxynucleotides
Authors: Michael Alt, Renate Renz, Peter H. Hofschneider, Gustav Paumgartner, Wolfgang H. Caselmann
Journal: Hepatology (1995)

The inhibitory effect of antisense phosphorothioate oligodeoxynucleotides (S-ODN) on hepatitis C viral gene expression and analyzed in an in vitro test system and in cell culture. S-ODN were directed against different stem loop structures in the 5'noncoding region (NCR) of the hepatitis C virus, (HCV) RNA and against a nucleotide stretch, including the start codon of the polyprotein precursor. The inhibitory effect of these S-ODN was quantified employing a viral RNA consisting of the first 407 nucleotides of a HCV type 1b genome fused to the coding sequence of the firefly luciferase gene. For in vitro assays this RNA was generated by in vitro transcription and used as a template in a rabbit reticulocyte lysate in vitro translation system. The production of active luciferase in the absence or presence of S-ODN was monitored using an enzymatic assay. The best results were obtained with S-ODN 4 directed against nucleotides 326 to 348, comprising the start AUG of the polyprotein coding sequence. With this oligonucleotide, a specific and dose-dependent effect was observed with a maximal inhibition of 96 +/- 1% at a S-ODN concentration of 4.14 mumol/L. For cell culture experiments, the hepatoblastoma cell line HepG2 was transfected with a plasmid expressing the HCV-luciferase fusion RNA. In this assay system S-ODN 2, complementary to nucleotides 264 to 282 of the HCV RNA, and S-ODN 4 were most efficient and reduced the viral translation by 96 +/- 0.4% and 94 +/- 0.7%, respectively, at a concentration of 0.3 mumol/L. The inhibition was specific (1) because the expression of the HCV-luciferase fusion RNA was not significantly impaired by the control S-ODN and (2) because the expression of an unrelated messenger RNA was not or only slightly downregulated. These data suggest that HCV gene expression can be inhibited effectively by antisense S-ODN. Therefore, this approach represents a promising perspective for the treatment of hepatitis C.
North of England evidence based guidelines development project: methods of guideline development
Authors: M. Eccles, Z. Clapp, J. Grimshaw, P. C Adams, B. Higgins, I. Purves, I. Russell
Journal: BMJ (1996)

use of all medicines.Campaigns to inform patients about self education would be to the public benefit. Good teamwork is essentialEncouraging the public to seek advice from the community pharmacist may lead to a greater proportion of visits to doctors resulting from referrals from the pharmacist, perhaps through formal referral forms.The change in status of prescription only medicines to pharmacy sale may also result in general practitioners referring patients to the pharmacist to purchase an over the counter medicine.The opportunities for teamworking between the two professions will grow.One way to encourage good teamwork is for general practitioners, pharmacists, and others to collaborate in the development of clinical treatment guidelines for specific conditions-for example, dyspepsia.I' The process of developing such guidelines has resulted in better understanding of different levels of professional care and produced guidelines that were welcomed by community pharmacists.Other initiatives to help integrate community pharmacists to achieve a recognised place in the primary health care team must be formally pursued.
Medical education companies got $170m in grants from 14 drug firms in 2010, study finds
Authors: Z. Kmietowicz
Journal: BMJ (2013)

Medical education companies got $170m in grants from 14 drug firms in 2010, study findsZosia Kmietowicz BMJ It is common for companies that provide medical education to get substantial funding from drug and device manufacturers, and many companies share the data they obtain from doctors with third parties, a US study has found.The research, published in JAMA, found that 18 medical communication companies received about $100m (£60m; €73m) from 13 US drug companies and one device manufacturer that released data on websites in 2010. 1 The researchers, from Columbia University in New York, were able to examine how much money the drug and device companies spent on grants to medical communications companies after the companies posted grant registries on their websites.Some did this because they had to as a result of legal settlements; others did it voluntarily.
Bioaccumulation of cadmium in marine organisms.
Authors: J M Frazier
Journal: Environmental Health Perspectives (1979)

A general review of cadmium concentrations in marine organisms and studies of cadmium bioaccumulation is presented. Factors which influence cadmium concentrations, such as regional differences, seasonal fluctuations and salinity, are discussed and species which are likely to accumulate cadmium identified. Experimental studies designed to investigate the influence of some of these factors on cadmium bioaccumulation in a filter feeding bivalve mollusk, the American oyster (Crassostrea virginica), are presented. Field studies of seasonal dynamics of cadmium in oysters indicate patterns which may be correlated with seasonal physiological activity. The bioaccumulation of cadmium following input to estuarine systems by natural phenomena is observed. Cadmium concentrations in oysters collected from regions of different salinity suggest an inverse relationship between cadmium concentration and salinity. Laboratory experiments designed to investigate mechanisms of cadmium accumulation demonstrate that an inducible cadmium binding protein, similar to metallothiomein, is present in the American oyster.
HIV Infection and Smoking Behavior-Reply
Authors: Neal A. Halsey
Journal: JAMA (1992)

<h3>In Reply.</h3> —Drs Davis and Samet make an appropriate point regarding the need to determine if there is a reduced risk in former smokers as compared with current smokers. We chose to report smoking status as reported at the time of HIV serologic testing when we asked only if patients had ever smoked. A potential problem with the analyses proposed by Davis and Samet is the uncertain time of HIV infection. The HIV infection could have occurred before a smoker's quitting, thus diluting any association between smoking status and HIV infection. Prospective cohort studies of women at risk would be the best way to evaluate this association and any possible decrease in risk following cessation of smoking. As implied by Drs Phillips and Davey Smith, unprotected sexual intercourse with an HIV-infected man is undoubtedly the key factor in the acquisition of HIV infection in women. Our detailed histories of sexual
Bronchogenic cyst treated by endobronchial ultrasound drainage
Authors: S Dhand, W Krimsky
Journal: Thorax (2008)

A 26-year-old female presented with progressive cough and breathlessness for 4 months. At her initial visit she was 6 weeks’ pregnant and reported that she could only climb 10 steps before becoming short of breath. Her past medical history was significant for a miscarriage the previous year, and her only medication was a prenatal vitamin. She was a registered nurse and had no history of smoking or drug use.

Physical examination was unremarkable. A chest x ray revealed a …
A To-Do List for the New CEO of the Federal Health Insurance Marketplace
Authors: Larry Levitt
Journal: JAMA (2014)

the program will expand to an additional 45 social workers, chaplains, nurses, and physicians. Major health systemsare also takingup the challenge. The Mayo Clinic has created amedical notedocumentingadvancedcare planning discussions between physicians and patients; these will be included in electronicmedical records and accessible to clinicians across clinic settings beginningnext year, said Cory Ingram, MD, medical director of palliative care at the Mayo Clinic in Rochester,Minnesota.Also, theMayoClinic is exploringusing telemedicine tobringpalliative care expertise into rural areas or to members of theMayo Clinic Care Network, as needed. “Palliative care is not esoteric,” Ingram said. “It can take a central role in the health caredelivery systemconcurrentwithhighly sophisticated, technologically advanced care, andMayo is committed to that across our system.” InTexas,BaylorHealthCareSystemhas achieved advanced certification in palliative care from the Joint Commission for medical centers inDallasandFortWorthand eventually plans to develop interdisciplinary palliative care teams at all of its hospitals. Two outpatient palliative care clinics haveopened inDallasandPlano,andthesystem is offering 9 hours of training in palliative medicine to hospitalists—the start of a targeted effort to educate specialists in the discipline. “We are trying to extend palliative care across the continuum of care, just like the IOM report recommends,” sa id Robert Fine, MD, Baylor’s clinical director for palliative care. He said the report provides much-needed support for these efforts. “Now, I can go to the hospital president and say ‘Hey, it’s not just Bob Fine talking about what we need to do: it’s the IOM.’”
Obstetrics and Gynecology
Authors: Ann B. Bernes
Journal: JAMA (1984)

The seventh edition of Willson, Carrington, and Ledger's<i>Obstetrics and Gynecology</i>maintains its excellence, particularly in general obstetrics. Comments on ultrasound have been inserted, and hopefully in the 8th edition will be appropriately placed before roentgenographic studies. The section on gynecology is brief but accurate. The section on aging is written with sensitivity. There is a useful chapter on the breast. Chapter 4, "Psychology and Life Periods of Women," is a distillate of unsubstantiated psychiatric views and useless outmoded male chauvinistic attitudes, which, it is hoped, Dr Willson will redo with Dr Carrington for future editions. The comment made on page 410 when discussing elderly primigravidas, "a greater percentage of women of this age have an abnormal labor on an emotional basis, either because psychologic problems prevented their marrying earlier or because a long period of infertility had a psychogenic basis," is also an inaccurate judgment of American society today.
UK drug service is ill equipped to deal with new "legal highs" taken by clubbers, conference is told
Authors: N. Hawkes
Journal: BMJ (2012)

Dozens of new drugs known as “legal highs” are being taken by nightclubbers in London, in ignorance of their dangers and potential long term effects, a conference on public health and cities was told on Monday 22 October.

Although use of heroin and cocaine was falling, especially among young adults,1 their place was being taken by a multitude of new drugs, said Owen Bowden-Jones of Central North West London NHS Foundation Trust. He is a founder of the Club Drug Clinic at Chelsea and Westminster Hospital, which opened its doors 18 months ago and which is now “overwhelmed” with people seeking help—not only from London but from all over England and even from mainland Europe.2

He told the City Health 2012 conference at the Guildhall …
Interaction of ethinyloestradiol with ascorbic acid
Authors: D J Back, A M Breckenridge, M L. Orme
Journal: BMJ (1981)

Interaction of ethinyloestradiol with ascorbic acid SIR,-The short report by Dr D J Back and others (9 May, p 1516) is admirably conservative of your editorial space but tantalisingly incomplete.If the toxic effects of the enhancement of ethinyloestradiol plasma concentration by ascorbic acid rise in parallel with the therapeutic activity, then the net benefit is nil.Furthermore, the authors have not discussed whether there is any similar interaction with the progestogen component.The balance of oestrogenic and progestogenic activity of the combined oral contraceptives is important in relation to efficacy and probably to the incidence of adverse effects on the circulatory system.'
Accuracy of the Papanicolaou Test in Screening for and Follow-up of Cervical Cytologic Abnormalities
Authors: Kavita Nanda, Douglas C. McCrory, Evan R. Myers, Lori A. Bastian, Vic Hasselblad, Jason D. Hickey, David B. Matchar
Journal: Annals of Internal Medicine (2000)

Purpose: To evaluate the accuracy of conventional and new methods of Papanicolaou (Pap) testing when used to detect cervical cancer and its precursors. Data Sources: Systematic search of English-language literature through October 1999 using MEDLINE, EMBASE, other computerized databases, and hand searching. Study Selection: All studies that compared Pap testing (conventional methods, computer screening or rescreening, or monolayer cytology) with a concurrent reference standard (histologic examination, colposcopy, or cytology). Data Extraction: Two reviewers independently reviewed selection criteria and completed 2 × 2 tables for each study. Data Synthesis: 94 studies of the conventional Pap test and three studies of monolayer cytology met inclusion criteria. No studies of computerized screening were included. Data were organized by cytologic and histologic thresholds used to define disease. For conventional Pap tests, estimates of sensitivity and specificity varied greatly in individual studies. Methodologic quality and frequency of histologic abnormalities also varied greatly between studies. In the 12 studies with the least biased estimates, sensitivity ranged from 30% to 87% and specificity ranged from 86% to 100%. Conclusions: Insufficient high-quality data exist to estimate test operating characteristics of new cytologic methods for cervical screening. Future studies of these technologies should apply adequate reference standards. Most studies of the conventional Pap test are severely biased: The best estimates suggest that it is only moderately accurate and does not achieve concurrently high sensitivity and specificity. Cost-effectiveness models of cervical cancer screening should use more conservative estimates of Pap test sensitivity.
Pseudomonas aeruginosa Vaccine in Cancer Patients
Authors: LOWELL S. YOUNG
Journal: Annals of Internal Medicine (1973)

During 1969 to 1972, 361 adult patients (176 vaccinees, 185 control patients) at a cancer center were randomized into a prospective study of the lipopolysaccharide vaccine derived from 7 serotypes ofPseudomonas aeruginosa. There were no significant differences in underlying disease, antibiotic therapy, or antineoplastic treatment between the vaccine and control groups. Fatal bacteremic pseudomonas infection occurred in 19 control subjects as opposed to in 10 vaccinees, and nonbacteremic pseudomonas infections associated with death occurred in 12 control patients and in 3 vaccinees. Protection against bacteremic death was not significant, but the mortality rate associated with pseudomonas infection was 13 out of 176 for the vaccinated group versus 31 out of 185 in the control group (P< 0.01). Fatal pseudomonas infections in both vaccine and control groups were associated with marked leukopenia, low titers of opsonizing pseudomonas antibodies, or both. As an adjunct to therapy of neoplasms, immunoprophylaxis with pseudomonas vaccine was associated with a significant but limited reduction in fatal pseudomonas infection. Vaccine administration was also accompanied by a high incidence of untoward reactions.
The management of congenital aortic stenosis.
Authors: J M Reid, E N Coleman
Journal: Thorax (1982)

The progress of 128 patients with congenital aortic stenosis has been followed from one to 28 (mean 14) years. Fifty-eight underwent cardiac catheterisation, and 46 (36% of the total) required surgical treatment. Of these, 42 were under 20 years old. Additional cardiac lesions were noted in five. Infective endocarditis was encountered in four. The onset of symptoms or increasing evidence of left ventricular hypertrophy on the electrocardiogram were the principal indications for catheterisation. Two-dimensional echocardiography is now important in this context. There were four deaths in the 46 surgically treated patients; three of these were early and the fourth was a late death three years after operation due to a massive cerebral embolus complicating infective endocarditis. The 42 survivors of operation and the 82 unoperated patients have remained under long-term supervision. Further surgery was necessary in 12 of the 42 surgically treated patients--valve replacement in seven of them two to eight years after valvotomy, replacement of a calcified xenograft valve in three, and repeat operation in two because of recurrence of subvalvar obstruction. Aortic stenosis is not a benign condition in childhood and adolescence. Close supervision is necessary and when any deterioration is detected further investigation as a prelude to probable surgery is mandatory. This should not be embarked on lightly in childhood unless there are pressing indications, particularly in view of the serious disadvantages of valve replacement in childhood.