Rapid-Onset Type 1 Diabetes Mellitus without Pancreatic Exocrine Dysfunction
Authors: Masatoshi Yamazaki, Tatsuhiko Hayashi
Journal: Annals of Internal Medicine (2002)

Letters16 July 2002Rapid-Onset Type 1 Diabetes Mellitus without Pancreatic Exocrine DysfunctionMasatoshi Yamazaki, MD, PhD and Tatsuhiko Hayashi, MD, PhDMasatoshi Yamazaki, MD, PhDMurakami General Hospital; Murakami 958-8533, Japan (Yamazaki, Hayashi)Search for more papers by this author and Tatsuhiko Hayashi, MD, PhDMurakami General Hospital; Murakami 958-8533, Japan (Yamazaki, Hayashi)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-137-2-200207160-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Imagawa and coworkers (1, 2) proposed a nonautoimmune fulminant subtype of type 1 diabetes mellitus characterized by the absence of insulitis and diabetes-related antibodies, rapid-onset elevated levels of serum pancreatic enzyme at diagnosis, and lymphocytic infiltration of the exocrine pancreas. However, pancreatic exocrine dysfunction may suggest an autoimmune rather than a nonautoimmune response in this subtype (3, 4).We examined the pancreatic biopsy specimen of a 50-year-old Japanese man with rapid-onset type 1 diabetes mellitus. He was admitted to our hospital with diabetic ketoacidosis 3 days after rapid-onset symptoms of hyperglycemia. His blood glucose concentration was 26.3 ...References1. Imagawa A, Hanafusa T, Miyagawa J, Matsuzawa Y. A novel subtype of type 1 diabetes mellitus characterized by a rapid onset and an absence of diabetes-related antibodies. Osaka IDDM Study Group. N Engl J Med. 2000;342:301-7. [PMID: 10655528] CrossrefMedlineGoogle Scholar2. Imagawa A, Hanafusa T, Miyagawa J, Matsuzawa Y. A proposal of three distinct subtypes of type 1 diabetes mellitus based on clinical and pathological evidence. Ann Med. 2000;32:539-43. [PMID: 11127931] CrossrefMedlineGoogle Scholar3. Lernmark A. Rapid-onset type 1 diabetes with pancreatic exocrine dysfunction [Editorial]. N Engl J Med. 2000;342:344-5. [PMID: 10655534] CrossrefMedlineGoogle Scholar4. Honeyman MC, Coulson BS, Harrison LC. A novel subtype of type 1 diabetes mellitus [Letter]. N Engl J Med. 2000; 342:1835; discussion 1837. [PMID: 10866554] Google Scholar Author, Article, and Disclosure InformationAuthors: Masatoshi Yamazaki, MD, PhD; Tatsuhiko Hayashi, MD, PhDAffiliations: Murakami General Hospital; Murakami 958-8533, Japan (Yamazaki, Hayashi) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPancreatic Inflammation Captured by Imaging Technology at the Onset of Fulminant Type 1 DiabetesVisceral Adipose Tissue Volume Estimated at Imaging Sites 5-6 cm Above L4-L5 Is Optimal for Predicting Cardiovascular Risk Factors in Obese Japanese MenExpression of Toll-like Receptors in the Pancreas of Recent-onset Fulminant Type 1 DiabetesA Case of Fulminant Type 1 Diabetes Mellitus Complicated with Ischemic IleitisFulminant type 1 diabetes in Caucasians: A report of three casesFulminant type 1 diabetes: a novel clinical entity requiring special attention by all medical practitionersT Cell Immunity to Glutamic Acid Decarboxylase in Fulminant Type 1 Diabetes without Significant Elevation of Serum AmylaseFulminant Type 1 Diabetes Mellitus 16 July 2002Volume 137, Issue 2Page: 145-146KeywordsAntibodiesBiopsyEnzymesHemoglobinHyperglycemiaLymphocytesPancreasPathogenesisRotavirusType 1 diabetes ePublished: 16 July 2002 Issue Published: 16 July 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...