tbuckley/cabot-search huggingface dataset:
Role of chronic stress and depression in periodontal diseases
Authors: Kimberly R. Warren, Teodor T. Postolache, Maureen E. Groer, Omar Pinjari, Deanna L. Kelly, Mark A. Reynolds
Journal: Periodontology 2000 (2013)

Abstract An extensive body of experimental and clinical evidence documents the negative impact of chronic psychological stress and depression on the immune system and health. Chronic stress and depression can result in general dysregulation of the immune system, of both cellular and humoral pathways, which may contribute to pathogenic infection and concomitant periodontal tissue destruction. In general, the evidence is consistent with the hypothesis that stress can modify the host defense and progression of periodontal infections in patients susceptible to periodontitis. However, substantial evidence also indicates that these conditions can mediate risk for disease, including periodontitis, through changes in health‐related behaviors, such as oral hygiene, smoking and diet. The unequivocal interpretation of studies has also been hampered, in part, by issues related to conceptualization of stress and depression, as well as commonly associated comorbidities, such as diabetes, that can modify the onset and progression of periodontal disease. In addition, stress and depression appear to fall into a spectrum, ranging from mild to severe, involving a complex interaction of genetic background, coping strategies and environment. Differences in the conceptualization of stress and depression are probably important in assessing associations with other biologic and clinical measures. Future studies are necessary to clarify the complex interactions of chronic stress and depression in periodontal diseases.
Tat-activating regulatory DNA-binding protein regulates glycolysis in hepatocellular carcinoma by regulating the platelet isoform of phosphofructokinase through microRNA 520
Authors: Yun-Yong Park, Sang-Bae Kim, Hee Dong Han, Bo Hwa Sohn, Ji Hoon Kim, Jiyong Liang, Yiling Lu, Cristian Rodriguez-Aguayo, Gabriel Lopez-Berestein, Gordon B. Mills, Anil K. Sood, Ju-Seog Lee
Journal: Hepatology (2013)

Abstract Metabolic changes are common features of many cancer cells and are frequently associated with the clinical outcome of patients with various cancers, including hepatocellular carcinoma (HCC). Thus, aberrant metabolic pathways in cancer cells are attractive targets for cancer therapy. However, our understanding of cancer-specific regulatory mechanisms of cell metabolism is still very limited. We found that Tat-activating regulatory DNA-binding protein (TARDBP) is a novel regulator of glycolysis in HCC cells. TARDBP regulates expression of the platelet isoform of phosphofructokinase (PFKP), the rate-limiting enzyme of glycolysis that catalyzes the irreversible conversion of fructose-6-phosphate to fructose-1,6-bisphosphate. Silencing of TARDBP expression in multiple HCC cell lines leads to impaired glucose metabolism and inhibition of in vitro and in vivo growth of HCC cells. Notably, the microRNA 520 (miR-520) family is an intermediate regulator of TARDBP-mediated regulation of glycolysis. Mechanistically, TARDBP suppressed expression of the miR-520 family, which, in turn, inhibited expression of PFKP. We further showed that expression of TARDBP is significantly associated with the overall survival of patients with HCC. Conclusion: Our study provides new mechanistic insights into the regulation of glycolysis in HCC cells and reveals TARDBP as a potential therapeutic target for HCC. (HEPATOLOGY 2013;)
Neoplasms and Transplantation — Trading Swords for Plowshares
Authors: David P. Schenkein, Robert S. Schwartz
Journal: New England Journal of Medicine (1997)

The recent death of former U.S. Senator Paul Tsongas at the age of 55 from complications of bone marrow transplantation was a reminder that we have not cleared this treatment of its most difficult problems. The senator had received two marrow transplants — an autograft in 1986 to treat lymphoma, and an allograft in 1996 to treat the myelodysplastic syndrome that was caused by the therapy he had received 10 years earlier.Secondary neoplasms are well-recognized complications of bone marrow grafts and solid-organ allografts. However, the tumors differ in kind and pathogenesis in the two groups of recipients. The neoplasms . . .
Abstract A24: Enhancing chemotherapy efficacy and antitumor immune activity by combined antisense downregulation of TS and IDO.
Authors: Saman Maleki Vareki, James Koropatnick
Journal: Cancer Research (2013)

Abstract Chemotherapy plays a major role in treatment of many common cancers. However, it is limited by intrinsic and/or acquired tumor cell resistance to anticancer drugs, often mediated by increased expression of genes mediating that resistance. An approach to increase chemotherapy effectiveness is to reduce expression of such genes using small molecules or RNAi to silence specific targets that cancer cells rely on for escape from death due to exogenous treatment or immune cell attack. We have previously shown that siRNA downregulation of thymidylate synthase (TS), the enzyme responsible for the de novo synthesis of thymidylate and a common target for some anti-cancer drugs (5FUdR, pemetrexed, and others) enhances the activity of these drugs in vitro. Using lower concentrations of anticancer drugs has the potential to decrease deleterious side effects, including therapy-induced toxicity to T cells capable of recognizing and killing tumor cells. In addition, certain tumor proteins including indoleamine 2,3-dioxygenase [IDO] can regulate immunosurveillance by inhibiting antitumor T and NK cell activity. IDO can also mediate tumor cell resistance to some anticancer drugs, such as imatinib. To assess the capacity of combined siRNA knockdown of TS and IDO in human tumor cells to increase sensitivity to anticancer drugs, we report that: a) TS siRNA downregulates TS by 90% in HCT-15 colon carcinoma cells, over 90% percent in A549 lung carcinoma cells, and by 80% in H441 lung carcinoma cells, b) shRNA expression vectors stably expressing IDO siRNA in multiple clonally-derived populations of A549 reduces IFNγ-induced IDO protein expression by over 95%. Transiently-transfected TS siRNA is being used, alone and in combination with stable shRNA-mediated reduction in IDO, to assess the utility of targeting both mRNAs to enhance sensitivity to TS-targeting drugs (5-FU, 5-FUdR, pemetrexed), DNA-damaging anticancer drugs (cisplatin, melphalan) and both, both in vitro and against human A549-derived tumour xenografts in immunocompromised mice without T cells but competent with respect to NK cell activity. Combined antisense targeting of both TS and IDO in human tumor cells has the potential to increase the effectiveness of anti-TS and other drugs, both by increasing tumor cell drug sensitivity and by combined enhancement of sensitivity to drug treatment and reduced inhibition of NK cell activity. Citation Format: Saman Maleki Vareki, James Koropatnick. Enhancing chemotherapy efficacy and antitumor immune activity by combined antisense downregulation of TS and IDO. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Immunology: Multidisciplinary Science Driving Basic and Clinical Advances; Dec 2-5, 2012; Miami, FL. Philadelphia (PA): AACR; Cancer Res 2013;73(1 Suppl):Abstract nr A24.
Allergen microarray detects high prevalence of asymptomatic IgE sensitizations to tropical pollen-derived carbohydrates
Authors: Clarissa R. Cabauatan, Christian Lupinek, Sandra Scheiblhofer, Richard Weiss, Margarete Focke-Tejkl, Prem L. Bhalla, Mohan B. Singh, Paul A. Knight, Marianne van Hage, John Donnie A. Ramos, Rudolf Valenta
Journal: Journal of Allergy and Clinical Immunology (2013)
Contribution of the TP53, OGG1, CHRNA3, and HLA-DQA1 Genes to the Risk for Lung Squamous Cell Carcinoma
Authors: Takashi Kohno, Hideo Kunitoh, Sachiyo Mimaki, Kouya Shiraishi, Aya Kuchiba, Seiichiro Yamamoto, Jun Yokota
Journal: Journal of Thoracic Oncology (2011)
A fat chance
Authors: D. Spence
Journal: BMJ (2008)

I always enjoyed the university annual eating competitions: five contestants at the zenith of their ability, swallowing whole pickled onions or boiled eggs, but only one winner. Gluttony was celebrated, and like many young people I never believed I would gain weight. But times change. Obesity is now common in the young and endemic to epidemic in adults. When we won the battle for wealth we lost the war of contentment. Doctors have foolishly rushed into this haemorrhaging of happiness.

Obesity …
THE ASSOCIATION BETWEEN EPICARDIAL FAT VOLUME AND CORONARY ARTERY PLAQUE CHARACTERIZATION
Authors: Kennosuke Yamashita, Myong Hwa Yamamoto, Seitarou Ebara, Toshitaka Okabe, Koichi Hoshimoto, Shigeo Saito, Tadayuki Yakushiji, Naoei Isomura, Hiroshi Araki, Chiaki Obara, Masahiko Ochiai
Journal: Journal of the American College of Cardiology (2013)
Cardiopulmonary Cerebral Resuscitation: Basic and Advanced Cardiac and Trauma Life Support: An Introduction to Resuscitation Medicine
Authors: Arthur R. MacNeil
Journal: JAMA (1989)

Directed to physicians and nonphysician instructors of resuscitation, this book has established itself as a leading text in the field. For the current edition Dr Peter Safar is joined by a coauthor, Dr Nicholas Bircher, to update and enhance the text. Their success in achieving these objectives in the resulting third edition proves their association to be indeed fortunate. Initial chapters of the book are presented as a manual of resuscitation techniques, which could serve as an essential text for all clinicians. Written with a particularly clear style, it is concise almost to the point of fault. Ample illustrations, most of them simple cartoons, provide clear direction for those practicing the motor skills necessary for successful resuscitation efforts. Printed in two colors, the text also uses a colored background to highlight vital treatment algorithms and descriptions of essential techniques. The authors have avoided those excesses of simplification that would have
Construction and characterization of fragmented mesenchymal-stem-cell sheets for intramuscular injection
Authors: Chun-Hung Chen, Yen Chang, Chung-Chi Wang, Chih-Hao Huang, Chieh-Cheng Huang, Yi-Chun Yeh, Shiaw-Min Hwang, Hsing-Wen Sung
Journal: Biomaterials (2007)
A Demonstration ON DIVERTICULA OF THE ALIMENTARY TRACT OF CONGENITAL OR OF OBSCURE ORIGIN: Given at the Royal College of Surgeons, England
Authors: A. Keith
Journal: BMJ (1910)

ABNORMAL diverticula of many different kinds are found in connexion with the alimentary tract.The annexed table will show you to what extent the various forms are represented in the college museum (Colamn A) and also in, the museums attached to the various medical schools in London (Column B).List oJ Specimens Illlstratiug Diverticiula of the Alimeufteq,1 Trlact in the Medical ]Jluseumsl. of London.A.I. Retro-cricoid diverticula of the pharyns ... ... 3 II.Traction diverticula of the oesophagus ... ...
Randomized, Controlled, Double-Blind Multicenter Comparison of the Efficacy and Tolerability of Ziprasidone and Olanzapine in Acutely Ill Inpatients With Schizophrenia or Schizoaffective Disorder
Authors: George M. Simpson, Ira D. Glick, Peter J. Weiden, Steven J. Romano, Cynthia O. Siu
Journal: American Journal of Psychiatry (2004)

Limited randomized, controlled trial data exist on possible differences between atypical antipsychotics in efficacy, overall tolerability, and important indices of health status. The authors compared the efficacy and tolerability of ziprasidone and olanzapine in the treatment of acutely ill inpatients with schizophrenia or schizoaffective disorder.In this 6-week, multicenter, double-blind, parallel-design, flexible-dose trial, patients were randomly assigned to receive ziprasidone (N=136) or olanzapine (N=133). Primary efficacy measures were improvement in Brief Psychiatric Rating Scale and Clinical Global Impression (CGI) severity scale scores; secondary measures were scores on the CGI improvement scale, Positive and Negative Syndrome Scale, and Calgary Depression Scale for Schizophrenia. Tolerability assessments included fasting lipid profiles, fasting glucose and insulin measurements, electrocardiography, and monitoring of vital signs and body weight.The overall mean daily doses were 129.9 mg (SD=27.3) for ziprasidone and 11.3 mg (SD=2.8) for olanzapine. Both antipsychotics were efficacious in improving symptoms and global illness severity. The two treatment groups did not differ significantly in primary or secondary efficacy measures at endpoint or in by-visit analysis. Both agents were well tolerated. Body weight, total cholesterol, triglycerides, and low-density lipoprotein cholesterol significantly increased with olanzapine but not with ziprasidone; all between-group comparisons of these variables were significant and favored ziprasidone. Olanzapine, but not ziprasidone, was associated with significant increases in fasting insulin level. No patient in either group exhibited a corrected QT interval >/=500 msec.During 6 weeks' treatment, ziprasidone and olanzapine demonstrated comparable antipsychotic efficacy. Differences favoring ziprasidone were observed in metabolic parameters.
Brendan Francis MacCarthy
Authors: Marcus Johns, Philip MacCarthy
Journal: BMJ (2006)

​FormerFormer consultant child psychiatrist, psychoanalyst, and president of the British Psychoanalytical Society (b 1927; q Dublin 1951; MD, MSc, FRCPsych), died from complications of a urological malignancy on 22 December 2005.



Figure 1



Brendan was on his way to becoming a ship's surgeon when a locum psychiatric post changed the course of his life. He was chairman of the Child Guidance Training Centre (at the Tavistock Clinic, London) between 1977 and 1981, and in the early 1980s was one of the first to recognise the prevalence of sexual abuse and incest and their long term detrimental effects on mental health. As director of the London Clinic of Psychoanalysis (1985-93) he was passionate about maintaining affordable analysis for those of modest means. He leaves a wife, Doreen; three sons; and four grandchildren.
Effect of Hypophysectomy on Electrolyte Excretion in Dogs with Ascites Produced by Thoracic Inferior Vena Cava Constriction
Authors: DAVID S. HOWELL, JAMES O. DAVIS, GERT L. LAQUEUR, ALFRED CASPER
Journal: Circulation Research (1955)

Following complete or nearly complete hypophysectomy in dogs with thoracic inferior vena cava constriction, a striking increase in sodium (Na) excretion occurred concomitant with a fall in femoral venous pressure. The previously high venous pressure and renal Na retention were restored by administration of thyrotropin (TSH), growth hormone injection or further constriction of the thoracic inferior vena cava, but adrenocorticotropic hormone (ACTH) was without effect on these functions. The data indicate that pituitary hormones influence the accumulation of ascitic fluid by contributing to the maintenance of an adequate level of venous hypertension.
Impact of Earthquakes on Takotsubo Cardiomyopathy
Authors: Hiroshi Watanabe, Makoto Kodama, Yuji Okura, Yoshifusa Aizawa, Naohito Tanabe, Masaomi Chinushi, Yuichi Nakamura, Tsuneo Nagai, Masahito Sato, Masaaki Okabe
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Successful Method of Removing Foreign Bodies from the Alimentary Canal.
Authors: J. F. Jenkins
Journal: JAMA (1891)

<h3>Editor Jour. Amer. Med. Ass'n:</h3> —During the past few months, the writer has been consulted on several occasions by anxious parents whose children have swallowed bits of coin. In each case I have invariably given the parents similar advice. Place the patient upon an exclusive potato diet. The potatoes may be either mashed, baked or boiled. This method in my hands has been thus far successful. This treatment is adopted, to the exclusion of all others, in the Vienna General Hospital, as I ascertained when visiting that hospital about a year ago. This manner of dealing with patients who have swallowed foreign bodies cannot be too generally known.
Health Effects of Urban Air Pollution
Authors: Roger S. Mitchell
Journal: JAMA (1979)

Urban air pollution, when sufficiently severe, can cause death in humans; these deaths occur preponderantly among those with increased susceptibility. Pollution--carbon monoxide and oxidants in particular--is capable of aggravating preexisting chronic heart and lung diseases. Pollution and tobacco (especially cigarette) smoke act synergistically in a causative role in chronic bronchitis and in an aggravating role in emphysema. Susceptibility to the effects of urban air pollution varies widely, with the most susceptible being fetuses, the newborn, the elderly, the infirm, those with chronic heart and lung diseases, and those who smoke. The carbon monoxide standards for sea level are probably too lenient for an altitude of 1,500 m and above. Using a broad definition of health, which takes into account concepts such as quality of life and social and mental well-being, few metropolitan residents would deny that their health is compromised by air that is malodorous, that irritates mucous membranes, and that obscures beautiful scenery.
Expression of decay‐accelerating factor and CD59 in lymphocyte subsets of healthy individuals and paroxysmal nocturnal hemoglobinuria patients
Authors: Shoichi Nagakura, Hideki Nakakuma, Kentaro Horikawa, Michihiro Hidaka, Tadashi Kagimoto, Makoto Kawakita, Motowo Tomita, Kiyoshi Takatsuki
Journal: American Journal of Hematology (1993)

Abstract The expression of phosphatidylinositol (PI)‐anchored complement‐regulatory membrane proteins on circulating blood cells has been well clarified; however, the PI proteins on lymphocyte subsets have not been fully analyzed yet. We examined the expression of decay‐accelerating factor (DAF) and CD59 on the T lymphocytes (CD2 − , CD3 + , CD4 − , and CD8 − ) and CD20 + B lymphocytes in ten healthy volunteers and 12 paroxysmal nocturnal hemoglobinuria (PNH) patients by cytofluorometry. In healthy controls, each subset of lymphocytes showed a small population of cells weakly positive and a large population of cells strongly positive for DAF and CD59, while erythrocytes showed a single population of cells positive for the PI proteins. The two‐population expression of DAF was most distinctive in CD8 − T cells among the subsets. In PNH, each subset of lymphocytes showed a moderately higher population of cells weakly positive and a smaller population of cells strongly positive for the membrane proteins compared with those in the healthy controls. Moreover, in some PNH cases, a negative population for the proteins was found in all subsets. Thus the analysis of PI‐anchored proteins on lymphocyte subsets (especially CD8 − T cells) was considered to be of diagnostic value in PNH patients who receive blood transfusion after hemolytic attack of affected erythrocytes. Furthermore, the two‐population expression of PI proteins in normal lymphocytes suggests that membrane PI protein would be a new subset marker of lymphocytes.
Hazards of Cardiac Pacemaker Implantation
Authors: Seymour Furman
Journal: JAMA (1966)

<h3>To the Editor:—</h3> Jensen et al (<b>195</b>:916, 1966) are to be commended on their discussion of the hazards both potential and actual during the technique of permanent transvenous pacemaker implantation. It would certainly seem that a transvenous pacemaker, because of its ease of insertion and relatively benign implantation, would offer a wide applicability to the ill or debilitated patient. Patient 1, who returned to regular sinus rhythm after institution of permanent transvenous pacing for four days would seem to have benefited from pacing with an externalized transvenous pacemaker because of the known proclivity for short periods of complete heart block and spontaneous return to sinus rhythm during acute myocardial infarction. Bruce et al (<i>Amer Heart J</i><b>69</b>:460,1965) review a collected series in which 43% of those patients with complete atrioventricular dissociation during acute myocardial infarction returned to regular sinus rhythm during the recovery period from the myocardial infarction
TCT-69 Safety and clinical performance of the drug eluting Osiro stent in patients with single de novo coronary artery lesions - II (BIOFLOW-II) -A quantitative analysis by IVUS and OCT-
Authors: Thierry Lefevre, Stephan Windecker, Michael Haude, Karl Stangl, Manel Sabate, J. Goicolea, Ton Slagboom, Paul Barragan, Stéphane Cook, Neil Weissman, Ravindra Pawar, Franz-Josef Neumann
Journal: Journal of the American College of Cardiology (2013)
Vasopressin reduces cardiac function and augments cardiopulmonary baroreflex resistance increases in man.
Authors: T J Ebert, A W Cowley, M Skelton
Journal: Journal of Clinical Investigation (1986)

We examined the effects of physiologic infusions of arginine vasopressin (AVP) on cardiovascular hemodynamics and on reflex responses initiated by decreasing cardiopulmonary baroreceptor stimulation (with lower body negative pressure) in 10 healthy, captopril-pretreated young men (19-27 yr). Their responses were compared with those of four volunteers given isosmotic infusion. Heart rate, stroke volume, blood pressure, and forearm blood flow were measured by electrocardiography, impedance cardiography, radial artery cannulation, and strain gauge plethysmography. Two 55-min infusions of AVP at rates of 0.15 and 0.40 ng/kg per min increased average plasma concentrations from control levels of 5 pg/ml to 18 and 36 pg/ml, respectively. These infusions resulted in progressive reductions of heart rate and cardiac output and increases of forearm and total peripheral resistance. Blood pressure increases were significant only during the larger AVP infusion rate. Lower body negative pressure provoked reflex increases of total peripheral resistance. These increases were enhanced 60% during AVP infusion compared with increases during control (pre-AVP). Baseline measurements and reflex responses were unchanged by isosmotic infusions. These results demonstrate that AVP has profound effects on cardiovascular function and augments cardiopulmonary baroreflex-mediated increases of peripheral resistance in man.
Recommended guidelines for in-hospital cardiac monitoring of adults for detection of arrhythmia
Authors: None Emergency Cardiac Care Committee Members, Allan S. Jaffe, James M. Atkins, John M. Field, Charles K. Francis, Robert S. Gibson, Stanley J. Goldberg, Alan D. Guerci, Robert M. Mentzer, Joseph P. Ornato, Eugene R. Passamani, Prediman K. Shah, Hugh C. Smith, W.Douglas Weaver
Journal: Journal of the American College of Cardiology (1991)