tbuckley/cabot-search huggingface dataset:
Autologous fibrin sealant (Vivostat®) for mesh fixation in laparoscopic transabdominal preperitoneal hernia repair
Authors: S. Schmidt, J. Langrehr
Journal: Endoscopy (2006)

The use of fibrin glue derived from humans or animals has been reported as an alternative method of mesh fixation, instead of staples, in inguinal hernia repair. However, fibrin sealants involve the potential risks of virus transmission or immunological reactions to foreign proteins. This risk could be avoided by using autologous fibrin derived from the patient. A feasibility study on the use of autologous fibrin was therefore carried out in patients undergoing laparoscopic transabdominal inguinal hernia repair.In a series of 10 patients undergoing laparoscopic transabdominal inguinal hernia repair, autologous fibrin was produced from 120 ml of the patient's blood during the hernia repair. The process took an average of 20 min. The perioperative and postoperative results were compared with those in a control group of 20 patients in whom conventional fibrin was used.Producing and applying the autologous fibrin was uncomplicated. No differences in the outcome were observed between the two groups. One patient in the conventional fibrin group developed a seroma. None of the patients reported persistent pain. No recurrences were observed after a mean follow-up period of 9 months (range 6 - 12 months) in the conventional fibrin group and 7 months (range 6 - 8 months) in the autologous fibrin group.This feasibility study suggests that autologous fibrin sealant allowed adequate mesh fixation that did not differ from that in a control group in whom conventional fibrin glue was used. Autologous fibrin may be an interesting alternative for a variety of laparoscopic and endoscopic applications.
Abstract 3496: SYK inhibition results in increased sensitivity of OVCAR-3 cells to paclitaxel
Authors: Aya Sultan, Cindy Y. Wang, George E. Duran, E. Brian Francisco, Jonathan S. Berek, Branimir I. Sikic
Journal: Cancer Research (2010)

Abstract In order to identify novel drug targets in ovarian cancers, we examined our ovarian cancer gene expression microarray data for expression of genes in the tyrosine kinase family. The spleen tyrosine kinase (SYK) gene was expressed in 73% of 55 ovarian cancer specimens, compared to 26% of 60 breast cancer specimens. Previous studies established the role of SYK in lymphocyte development, immune cell activation, and tumor progression. We found SYK to be expressed in 6 of 10 ovarian carcinoma cell lines. Among its many targets, SYK can bind microtubules and other molecules associated with the cytoskeleton. Because of this ability, we studied the relationship of SYK expression to cellular sensitivity to taxanes. We focused on the OVCAR-3 cell line, which was one of the highest SYK-expressing cell lines, to elucidate the potential effects of SYK on taxane sensitivity. Our results demonstrate that knockdown of SYK expression by siRNA resulted in a one log-fold increased sensitivity of OVCAR-3 cells to the taxane, paclitaxel. Furthermore, this effect was durable, as knockdown of SYK and sensitization to paclitaxel persisted over 128 hours. The potential effects of SYK on tubulin polymerization are currently being investigated. We will evaluate potential upstream and downstream targets to elucidate the pathway(s) responsible for SYK effects and determine whether SYK levels contribute to tumor resistance to chemotherapeutic agents. Understanding the growth signals in drug sensitive and resistant ovarian cancer cell lines and tumor samples may eventually lead to new therapeutic approaches for ovarian cancers. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3496.
Reflections on a Bone Marrow Transplant
Authors: Michael C. Dohan
Journal: Annals of Internal Medicine (2000)

On Being a Patient4 April 2000Reflections on a Bone Marrow TransplantMichael C. Dohan, MDMichael C. Dohan, MDBurlington, MA 01803 (Dohan)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-7-200004040-00013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail I am 63 years old and have been living with chronic lymphocytic leukemia for more than 7 years. Two years ago, progression of symptoms and a worsening hematologic profile despite chemotherapy forced me to make an important personal decision regarding whether or not to receive a bone marrow transplant. As a physician, I knew that transplants for chronic lymphocytic leukemia were controversial and not based on rigorous, controlled studies. It would be risky and difficult, but there was still so much I wanted to do, including living long enough to play an important role in my grandchildren's lives. I chose ... Author, Article, and Disclosure InformationAffiliations: Burlington, MA 01803 (Dohan)Corresponding Author: Michael C. Dohan, MD, 281 Cambridge Street, Burlington, MA 01803; e-mail, [email protected]org. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByLife on the Receiving End: A Qualitative Analysis of Health Providers??? Illness NarrativesSuccessful management of claustrophobia and depression during allogeneic SCTCaring for Colleagues 4 April 2000Volume 132, Issue 7Page: 589-590KeywordsAnxietyBone marrowChemotherapyChronic lymphocytic leukemiaEmotionsNauseaNursesRadiation therapySleepTransplantation Issue Published: 4 April 2000 CopyrightCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
PERTUSSIS AS A NEUROSIS.
Authors: S. J. RADCLIFFE
Journal: JAMA (1896)

The pathology of pertussis has long been in doubt; this is well shown by its varied and uncertain therapeutics. The definition of the malady is usually based upon its most prominent symptoms—the characteristic paroxysmal cough and consecutive whoop. The cause of this characteristic cough and whoop has never been positively located. It is said by some to be a local irritation involving the pharyngo-laryngeal space, set up by some external influence, possibly bacterial; some, that in addition the morbid irritant is absorbed through the lymphatics and blood vessels and produce a systemic febrile state, and some that it is a vague commingling of various elements, local and general, physical and nervous, and still others that its phenomena are entirely reflex. There is no doubt regarding its infectious nature, but the peculiar mode of this infection is still veiled in uncertainty. It may be from exhalations from the vomited matter or
Electrophysiologic effects of nitroglycerin during experimental coronary occlusion.
Authors: R Levites, M M Bodenheimer, R H Helfant
Journal: Circulation (1975)

Previous studies have shown that nitroglycerin (TNG) exerts beneficial electrophysiological effects in the setting of acute myocardial ischemia. To investigate the basis for these actions, the effects of TNG during coronary occlusion were studied in 19 anesthetized mongrel dogs. Refractory periods (obtained by extrastimulus method) and conduction times measured from local electrograms were determined in potentially ischemic and nonischemic areas prior to and after varying periods of occlusion of the left anterior descending coronary artery and following administration of TNG (300-400 mug intravenous bolus followed by an infusion titrated to reduce systolic blood pressure by 20 mm Hg). Following 15 minutes of occlusion, refractory periods in the ischemic zones shortened to 83% of control (P less than 0.001) resulting in a difference between refractory periods in the nonischemic and ischemic zones of 17.7%. After TNG administration this difference was decreased to 10.0% (P less than 0.001). However, with periods of occlusion of 60-90 min TNG did not significantly affect the difference of refractory periods. TNG had no significant effects on conduction times in nonischemic or ischemic areas. In six dogs, the effects of coronary occlusion and TNG on ventricular automaticity were examined by induction of complete heart block. The idioventricular rate and ventricular escape intervals after cessation of ventricular overdrive were used as indices of automaticity. Control idioventricular rates (62.5 +/- 3.7 beats/min) remained unchanged following both coronary occlusion (62.0 +/- 3.9) and TNG administration (60.7 +/- 3.2). Similarly, mean control escape intervals (1.84 +/- 0.2 sec) did not change after occlusion (1.78 +/- 0.3 sec) or TNG administration (1.86 +/- 0.2 sec). In conclusion, these observations suggest that 1) TNG enhances the electrical stability of the acutely ischemic myocardium by decreasing the difference of refractory periods between nonischemic and ischemic areas in the immediate period following occlusion, 2) since TNG has no significant effects on ventricular automaticity, its beneficial effects might be limited in suppression of arrhythmias of re-entrant origin.
Pathobiological Implications of MUC4 in Non–Small-Cell Lung Cancer
Authors: Prabin Dhangada Majhi, Imayavaramban Lakshmanan, Moorthy P. Ponnusamy, Maneesh Jain, Srustidhar Das, Sukhwinder Kaur, Su Tomohiro Shimizu, William W. West, Sonny L. Johansson, Lynette M. Smith, Fang Yu, Cleo E. Rolle, Poonam Sharma, George B. Carey, Surinder K. Batra, Apar Kishor Ganti
Journal: Journal of Thoracic Oncology (2013)
Impulse oscillometry versus spirometry in a long-term study of controller therapy for pediatric asthma
Authors: Gary L. Larsen, Wayne Morgan, Gregory P. Heldt, David T. Mauger, Susan J. Boehmer, Vernon M. Chinchilli, Robert F. Lemanske, Fernando Martinez, Robert C. Strunk, Stanley J. Szefler, Robert S. Zeiger, Lynn M. Taussig, Leonard B. Bacharier, Theresa W. Guilbert, Shelley Radford, Christine A. Sorkness
Journal: Journal of Allergy and Clinical Immunology (2008)
TCT-140 Prognostic value of manual thrombus aspiration in patients undergoing Primary Percutaneous Coronary Intervention
Authors: Cid Alvarez Ana Belén, Alvarez Alvarez Belen, Ramiro Trillo, Lopez Otero Diego, Ocaranza Sanchez Raymundo, Pablo Souto-Castro, Agustín Fernandez-Cisnal, Gestal Romaní Santiago, Pereira Lopez Eva, Jose Ramon Gonzalez-Juanatey
Journal: Journal of the American College of Cardiology (2014)
Hyperammonemia in Women with a Mutation at the Ornithine Carbamoyltransferase Locus
Authors: Pamela Hawks Arn, Elizabeth R. Hauser, George H. Thomas, Gail Herman, David Hess, Saul W. Brusilow
Journal: New England Journal of Medicine (1990)

ORNITHINE carbamoyltransferase deficiency is an X-linked disorder of urea synthesis. Its clinical manifestations — lethargy, vomiting, coma, and cerebral edema — are related to hyperammonemia and hyperglutaminemia. Other laboratory findings include low plasma levels of arginine, citrulline, and urea. Orotic aciduria also occurs commonly during hyperammonemic episodes.1 The phenotypic consequences of mutations at the ornithine carbamoyltransferase locus in children are well known; they are less well described in adults. In newborn boys, ornithine carbamoyltransferase deficiency is manifested by hyperammonemic coma that often leads to death or, in those who recover from coma, mental retardation and cerebral palsy.1 Older boys may . . .
Tumor-Cell Markers: A Biologic Shell Game?
Authors: Hubert J. Wolfe
Journal: New England Journal of Medicine (1978)

The concept that the production of isoenzymes, isohormones, metabolites or other tumor-cell products could be employed to identify the neoplastic state in man through their measurement in serum, effusions, urine or tissue extracts has engendered considerable interest and enthusiasm in the medical community. A large number of these products, identified in patients with neoplasms and present only in trace amounts in normal adults, have also been found in early stages of human development. This association has led to the practice of referring to such markers as "oncofetal antigens."1 These products can reflect changes in total-body tumor burden, and have been . . .
Pulmonary tuberous sclerosis presenting with pleural effusion.
Authors: R B Broughton
Journal: BMJ (1970)

Preliminary ComrnunicationsMEDIALJoURNAL 477of knowing whether it is in primary or secondary apncea.If in primary apnoea it will recover without intervention, but if analeptic drugs are given it will start gasping more quickly and vigorously, giving rise to the clinical impression that the drug is life-saving.Effective I.P.P.V., though also unnecessary, would not be harmful and would similarly hasten recovery.If the baby is in secondary apnoea it will die unless given I.P.P.V., and the administration of analeptics will be of no benefit.What evidence there is suggests that lobeline or ethami- van will seriously jeopardize the chances of resuscitation by I.P.P.V. because they induce hypotension at this stage.We feel strongly that analeptic drugs have no place in obstetric or neonatal departments, as they are of no benefit in primary apnoea and potentially lethal in secondary apnoea.The availability of personnel trained in intubation of small babies is of paramount importance, as recommended by the Central Midwives Board (February 1968).The practice of putting a drop or two of ethamivan on the tongue while waiting for the anaesthetist or to see what happens should be discouraged.
Enlargement of One or More Vertebrae
Authors: Robert J. Corcoran
Journal: JAMA (1977)

<h3>Common</h3> Acromegaly Paget's disease <h3>Uncommon</h3> Benign bone tumor (eg, hemangioma, aneurysmal bone cyst, giant cell tumor) Compensatory enlargement from non-weight-bearing (eg, paralysis) Congenital enlargement Fibrous dysplasia Hyperphosphatasia <h3>Diagnosis</h3> Paget's disease. <h3>Comment</h3> The enlarged vertebral body seen in acromegaly occurs particularly in the anteroposterior and transverse diameters. Occasionally there is added vertical height. The vertebral body enlargement is the result of new bone development from calcification of adjacent proliferating cartilage. A demarcation may be seen between the new bone growth and the original vertebral body. Initially, the intervertebral disk space is of normal height, but eventually the degenerative spondylosis associated with acromegaly causes secondary narrowing of the disk spaces, especially in the lower dorsal spine. There is accentuation of the dorsal kyphosis of the thoracic spine with compensatory hyperlordosis of the lumbar spine. The posterior aspect of the vertebral bodies, especially in the
Protein Supplements Increase Serum Insulin-Like Growth Factor-I Levels and Attenuate Proximal Femur Bone Loss in Patients with Recent Hip Fracture
Authors: Marc-Andre Schurch
Journal: Annals of Internal Medicine (1998)

Background: Elderly persons who have osteoporotic hip fracture are often undernourished, particularly with respect to protein. Protein malnutrition may contribute to the occurrence and outcome of hip fracture. Objective: To investigate whether oral protein supplements benefit bone metabolism in patients with recent hip fracture. Design: 6-month, randomized, double-blind, placebo-controlled trial with a 6-month post-treatment follow-up. Setting: University orthopedic ward. Patients: 82 patients (mean age, 80.7 ± 7.4 years) with recent osteoporotic hip fracture. Patients received calcium supplementation, 550 mg/d, and one dose of vitamin D, 200 000 IU (at baseline). Intervention: Protein supplementation, 20 g/d, or isocaloric placebo (among controls). Measurements: Bone mineral density, biochemical markers of bone remodeling, calciotropic hormone levels, biochemically evaluated nutritional and immunologic status, and muscle strength were measured every 6 months. Results: Compared with controls, patients who received protein supplements had significantly greater increases in serum levels of insulin-like growth factor-I (85.6% ± 14.8% and 34.1% ± 7.2% at 6 months; difference, 51.5 percentage points [95% CI, 18.6 to 84.4 percentage points]; P = 0.003) and an attenuation of the decrease in proximal femur bone mineral density ( −2.29%± 0.75% and −4.71%± 0.77% at 12 months; difference, 2.42 percentage points [CI, 0.26 to 4.59 percentage points]; P = 0.029). Seven and 13 new vertebral deformities were found among patients who received protein supplements and controls, respectively (P > 0.2). Median stay in rehabilitation wards was shorter for patients who received protein supplements than for controls (33 days [CI, 29 to 56 days] and 54 days [CI, 44 to 62 days]; difference, 21 days [CI, 4 to 25 days]; P = 0.018). Conclusion: Protein repletion after hip fracture was associated with increased serum levels of insulin-like growth factor-I, attenuation of proximal femur bone loss, and shorter stay in rehabilitation hospitals.
The Pan-American League for the Study and Control of Rheumatic Diseases
Authors: L. T. Swaim
Journal: Annals of the Rheumatic Diseases (1945)

The objectives of the Pan-American League as drawn up in the Statutes are as follows: "(a) to strengthen the cultural bonds between the countries of North and South America; (b) to further efforts to alleviate suffering from rheumatic diseases and to institute measures of prevention; (c) to compile and
Rye flour induces a stronger early bronchial response than wheat flour in occupational asthma
Authors: L. Bensefa, C. Villette, F. Tabka, E. Causse‐Sounillac, J. F. Fabriès, D. Choudat
Journal: Allergy (2004)

Our aims were to compare the doses of wheat and rye flour that induce early bronchial responses in occupationally exposed asthmatic subjects and to assess the effects of the dose of inhaled flour, the duration of exposure and the dose rate.Ten patients underwent tests with lactose, wheat flour and rye flour. We compared the decrease in forced expiratory volume in 1 s (FEV(1)) observed during the challenge with flour and with lactose. We also calculated the amount of flour that was instantaneously active.Seven subjects had significantly decreased FEV(1) values following exposure to wheat and rye flour and two subjects only did so for rye flour. The provocative dose (PD, dose required to reduce FEV(1) by 15%) of rye was lower than that of wheat flour (geometric mean; PD(15) rye: 95 microg; wheat: 368 microg). The calculated doses of rye and wheat flour were better correlated with the change in FEV(1) than were the cumulative doses.The bronchial response was greater with rye than with wheat flour. The response was related to the dose of allergen inhaled and to the dose rate.
Therapeutic Effects of Deleting Cancer-Associated Fibroblasts in Cholangiocarcinoma
Authors: Joachim C. Mertens, Christian D. Fingas, John D. Christensen, Rory L. Smoot, Steven F. Bronk, Nathan W. Werneburg, Michael P. Gustafson, Allan B. Dietz, Lewis R. Roberts, Alphonse E. Sirica, Gregory J. Gores
Journal: Cancer Research (2012)

Abstract Cancer-associated fibroblasts (CAF) are abundant in the stroma of desmoplastic cancers where they promote tumor progression. CAFs are “activated” and as such may be uniquely susceptible to apoptosis. Using cholangiocarcinoma as a desmoplastic tumor model, we investigated the sensitivity of liver CAFs to the cytotoxic drug navitoclax, a BH3 mimetic. Navitoclax induced apoptosis in CAF and in myofibroblastic human hepatic stellate cells but lacked similar effects in quiescent fibroblasts or cholangiocarcinoma cells. Unlike cholangiocarcinoma cells, neither CAF nor quiescent fibroblasts expressed Mcl-1, a known resistance factor for navitoclax cytotoxicity. Explaining this paradox, we found that mitochondria isolated from CAFs or cells treated with navitoclax both released the apoptogenic factors Smac and cytochrome c, suggesting that they are primed for cell death. Such death priming in CAFs appeared to be due, in part, to upregulation of the proapoptotic protein Bax. Short hairpin RNA-mediated attenuation of Bax repressed navitoclax-mediated mitochondrial dysfunction, release of apoptogenic factors, and apoptotic cell death. In a syngeneic rat model of cholangiocarcinoma, navitoclax treatment triggered CAF apoptosis, diminishing expression of the desmoplastic extracellular matrix protein tenascin C, suppressing tumor outgrowth, and improving host survival. Together, our findings argue that navitoclax may be useful for destroying CAFs in the tumor microenvironment as a general strategy to attack solid tumors. Cancer Res; 73(2); 897–907. ©2012 AACR.
A piece of my mind. Washing clothes
Authors: E. C. Ritchie
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Short-term prognosis of cirrhotics with spontaneous bacterial peritonitis (SBP). Multivariate study
Authors: JM Llovet, R Planas, R Morillas, JC Quer, E Cabré, J Boix, P Humbert, M Guilera, E Doménech, X Bertrán, MA Gassull
Journal: Journal of Hepatology (1991)
Avoidance of Upward Creep Artifact During TI-201 Myocardial Perfusion Tomography Using Adenosine Infusion
Authors: CONSTANTINOS ANAGNOSTOPOULOS, DUDLEY PENNELL, ROBIN LANEY, S RICHARD UNDERWOOD
Journal: Clinical Nuclear Medicine (1995)

Upward motion of the heart during tomographic data acquisition of stress TI-201 myocardial perfusion images may lead to artifacts in the reconstructed tomograms. The authors report a patient in whom this occurred, giving the impression of reversible perfusion defects. Although correction of the raw data abolished the artifact, a separate study using adenosine vasodilatlon produced normal images. The authors conclude that adenosine vasodilation should be considered in preference to dynamic exercise in patients at risk of this artifact, such as those with a high exercise tolerance.
Irish public would prefer legislation to protect Guthrie card archive rather than destroy it
Authors: J. Allen, P. McCarthy, E. M. Dempsey, J. O. Hourihane
Journal: BMJ (2013)

The Republic of Ireland initiated the national neonatal blood card screening programme in 1966. In 2012 the Department of Health and Children (DOHC) announced its decision to destroy much of the archive from before 2010 (>1 million cards), fearful of non-compliance with data protection legislation.1 After lobbying by interested parties,2 this destruction was deferred in March 2013.3 The DOHC sought justification for retaining the archive in relation to existing …
Role of Preoperative Positive Apical Biopsies in the Prediction of Specimen&amp;ndash;Confined Prostate Cancer after Radical Retropubic Prostatectomy: A Multi&amp;ndash;Institutional Study
Authors: Bernard Malavaud, Arnauld Villers, Vincent Ravery, Christophe Tollon, Pascal Rischmann, Jean-Paul Charlet, Pierre Plante, Laurent Boccon-Gibod, Jean Pierre Sarramon
Journal: European Urology (2000)
Activation of toll-like receptor 4 in adventitial cells by lipopolysaccharide induces neointima formation in a mouse model
Authors: Arvan Vink, Jelger J. van der Meer, Ben van Middelaar, Paul H. Quax, Cornelius Borst, Gerard Pasterkamp, Dominique P. de Kleijn
Journal: Journal of the American College of Cardiology (2002)