tbuckley/cabot-search huggingface dataset:
Secondary Syphilis with Negative Serological Tests for Syphilis
Authors: Sanford M. Vaughan
Journal: JAMA (1961)

<h3>To the Editor:—</h3> A 40-year-old man was seen at the 97th General Hospital on Nov. 24, 1960, because of a generalized maculopapular eruption of 2-months duration. He gave a history of first developing a slightly pruritic papular eruption of the face in September, 1960. Within a month, the eruption had spread to involve the crural area, and later it became generalized, including the palms and soles. He had also noted transient twinges of pain in the right leg, commonly at night, for one month prior to admission, and he felt tired. There was no history of drug ingestion or sensitivity to vaccination, and 2 complement-fixation tests had been negative. He admitted to having extramarital contact in June, 1960. Physical examination revealed a generalized maculopapular eruption, including palms and soles, but no mucous membrane involvement or hair loss, and a generalized lymphadenopathy. Complement-fixation and flocculation tests were negative, but darkfield examination
A controlled trial of anti-tuberculosis chemotherapy in the early complicated pneumoconiosis of coalworkers
Authors: J. D. Ball, G. Berry, W. G. Clarke, J. C. Gilson, J. Thomas, C. Exall, M. Roberts
Journal: Thorax (1969)

A controlled trial in coalminers under the age of 50 in South Wales with sputum-negative, early complicated pneumoconiosis was used to compare three regimes: (1) chemotherapy (rest in hospital and 1 g. streptomycin, 200 mg. INH, 10 g. PAS, for 3 months; then 200 mg. INH, 10 g. PAS for 9 months); (2) rest (in hospital for 3 months); and (3) a working group. The initial and three-year radiographs were assessed by two methods in 173 (96%) of the 180 men entering the trial. No beneficial effect of chemotherapy was demonstrated and this factor was not related to the completeness of the chemotherapy. The variation between individuals in the rate of progression and in the development of new shadows was unrelated to chest symptoms, smoking habits, initial erythrocyte sedimentation rate, or special features in the initial radiographs, so these did not provide any useful predictive characteristics. Those with an initial negative Mantoux (1 T.U.) showed significantly less progression than those with a positive Mantoux. The lack of benefit and the short- and long-term complications of chemotherapy (weight gain, reduction in ventilatory capacity, dyspepsia, and streptomycin toxicity) show that this treatment is contra-indicated in miners with early complicated pneumoconiosis without a positive sputum. That new shadows develop during chemotherapy adds to the evidence from other sources that tuberculosis is unlikely to be a major factor in the pathogenesis of complicated pneumoconiosis in this area. <i>Mycobacterium peregrinum</i> (Runyon group IV) was isolated in three cases.
Maximal heart rate and treadmill performance of healthy women in relation to age.
Authors: L T Sheffield, J A Maloof, J A Sawyer, D Roitman
Journal: Circulation (1978)

Maximal treadmill exercise heart rate, work capacity and electrocardiographic response were studied in 95 asymptomatic, predominantly sedentary women between the ages of 19 and 69 years. Average maximal heart rate (MHR) was found inversely related to age, such that MHR = 216 -0.88 (years of age) +/- 10 beats/min (X +/- 1 SD). Treadmill exercise endurance was 7.64 min +/- 1.99. The reduction of treadmill endurance with advancing age was not statistically significant. Asymptomatic ST-segment depression occurred in 6% of subjects. In 5% the ST segment sloped upward, and in 1% it was flat. Mean age of women with ST depression was 52 years, compared with 39 years mean age of all subjects. Premature beats during exercise were found in 20 of 95 subjects, and were not related to age. Graded exercise testing of women employing target heart rates should use heart rate tablets developed especially for women. These tables do not require correction for athletically trained for sedentary life-style.
EARLY RECOGNITION AND MANAGEMENT OF THE MENTALLY DISTURBED.
Authors: W. S. WATSON
Journal: JAMA (1895)

Nothing has so much tended to confuse, distort and implant the supposed need of harshness in the management of the insane as our forgetfulness of the infirmities of the human mind. It was assumed that a broad and unmistakable line of separation marked the difference between the sane and the insane, that detection was, therefore, a matter of ease, while the facts are that a mere mist, a veil separates, and a something that is easily broken through. There is a certain tendency to disorder incident to every mind as regards strength, harmony and development. Do not the eccentricities, the proneness to vice and crime, the indulgence of the passions, the weaknesses of life demonstrate the inherent tendency to mental disorders? As our body is diversified with counterbalancing functions, and in its delicacy and completeness of arrangement is constantly liable to disease and in fact engenders within itself the elements
The Pro-Apoptotic Protein Bim Is a MicroRNA Target in Kidney Progenitors
Authors: Jacqueline Ho, Priyanka Pandey, Tobias Schatton, Sunder Sims-Lucas, Myda Khalid, Markus H. Frank, Sunny Hartwig, Jordan A Kreidberg
Journal: Journal of the American Society of Nephrology (2011)

Understanding the mechanisms that regulate nephron progenitors during kidney development should aid development of therapies for renal failure. MicroRNAs, which modulate gene expression through post-transcriptional repression of specific target mRNAs, contribute to the differentiation of stem cells, but their role in nephrogenesis is incompletely understood. Here, we found that the loss of miRNAs in nephron progenitors results in a premature depletion of this population during kidney development. Increased apoptosis and expression of the pro-apoptotic protein Bim accompanied this depletion. Profiling of miRNA expression during nephrogenesis identified several highly expressed miRNAs (miR-10a, miR-106b, miR-17-5p) in nephron progenitors that are either known or predicted to target Bim. We propose that modulation of apoptosis by miRNAs may determine congenital nephron endowment. Furthermore, our data implicate the pro-apoptotic protein Bim as a miRNA target in nephron progenitors.
Tick Bite Appendicitis
Authors: Eli Schwartz
Journal: JAMA (1988)

To the Editor.  —We would like to report a case that emphasizes basic physical examination technique.  Report of a Case.  —A 26-year-old male tourist arrived in Kathmandu, Nepal, then traveled to the jungle area south of Nepal for the next few days. He flew up to the village of Jomoson (3048 m), where he developed diarrhea, vomiting, and fever shortly after arrival. He was seen by a physician in the local hospital who detected lower right quadrant tenderness and suspected acute appendicitis.  He was advised to fly back to Kathmandu as soon as possible, since surgical facilities were not available in Jomoson. On presentation to our clinic in Kathmandu he did not appear to be in acute distress, though he complained of lower right quadrant abdominal pain. He had a temperature of 37.8°C and a pulse rate of 60 beats per minute. Abdominal examination revealed point tenderness just lateral to
718-4 Lack of Positive Inotropic Effect by p-Adrenoceptor Stimulation in the Failing Myocardium is not Due to Inability to Supply Intracellular Ca 2+ nor cAMP: Studies in Dahl Rat Heart Failure Model
Authors: Moriaki Inoko, Yasuki Kihara, Shigetake Sasayama
Journal: Journal of the American College of Cardiology (1995)
Classification of Type 1 Diabetic Females With Bulimia Nervosa Into Subgroups According to Purging Behavior
Authors: Masato Takii, Yasuko Uchigata, Takehiro Nozaki, Hiroaki Nishikata, Keisuke Kawai, Gen Komaki, Yasuhiko Iwamoto, Chiharu Kubok
Journal: Diabetes Care (2002)

OBJECTIVE—To classify type 1 diabetic females with bulimia nervosa (BN) by type of inappropriate compensatory behavior in order to prevent weight gain (ICB) and to investigate the group differences. RESEACH DESIGN AND METHODS—Type 1 diabetic females with BN, diagnosed by structured diagnostic interview based on DSM-IV (Diagnostic and Statistical Manual of Mental Disorders, 4th ed.) criteria, were classified by type of ICB as follows: 1) only severe insulin omission as an ICB (BN-I) (n = 22), 2) both severe insulin omission and self-induced vomiting and/or laxative abuse (BN-IP) (n = 22), or 3) no insulin omission but another ICB (BN-NI) (n = 11). The clinical characteristics of these three groups and a binge-eating disorder (BED) group (n = 24) were compared. RESULTS—The BN-IP and BN-I groups had the highest HbA1c levels. The BN-IP group had the highest rates of diabetic neuropathy, retinopathy, and nephropathy. The BN-NI group had the second highest rates of neuropathy and retinopathy. The BN-IP group had the highest frequencies of diabetes- and ketoacidosis-related hospital admissions, and the BN-I group had the second highest frequencies. The BN-NI group showed the highest scores on psychological tests related to depression, anxiety, eating disorder psychopathology, and perfectionism. The BN-NI group had the highest rate of history of visits to a psychiatrist, and the BN-IP group had the second highest history. CONCLUSIONS—Type 1 diabetic females with BN seem not to be homogenous and can be classified into three distinctive subgroups by type of ICB. Individuals with BN-IP had the most severe problems with both medical and psychological/behavioral aspects. Individuals with BN-NI manifested the highest psychological distress. The BN-I group had comparatively mild distress despite having the poorest metabolic control. Each BN group manifested more severe pathology than the BED group.
Pharmacoepidemiology: An Introduction
Authors: Samuel Shapiro
Journal: Annals of Internal Medicine (1998)

Medical Writings1 November 1998Pharmacoepidemiology: An IntroductionSamuel Shapiro, MB, FRCP(E)Samuel Shapiro, MB, FRCP(E)Slone Epidemiology Unit, Boston University School of Medicine, Brookline, MassachusettsSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-129-9-199811010-00048 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Pharmacoepidemiology: An Introduction; 3rd edition. Hartzema AG, Porta MS, Tison HH; eds. 670 pages. Cincinnati: Harvey Whitney Books; 1998. $85.00. ISBN 0929375181. Order phone 513-793-3555.Field of medicine: Epidemiology and clinical pharmacology.Format: Softcover book.Audience: Epidemiologists; statisticians; pharmacologists; pharmacists; drug regulators; and persons concerned with drug safety, drug efficacy, drug regulation, outcome assessment, and quality of life.Purpose: To provide a comprehensive overview of pharmacoepidemiology.Content: The book covers a disparate array of subjects, including the process of drug approval and regulation; safety assessment; premarketing studies; use; genetic and pharmacologic markers of drug effects; methodology, including study design, analysis, ... Author, Article, and Disclosure InformationAffiliations: Slone Epidemiology Unit, Boston University School of Medicine, Brookline, Massachusetts PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited by1,2,5-Thiadiazoles 1 November 1998Volume 129, Issue 9Page: 760KeywordsClinical epidemiologyClinical pharmacologyDrug regulationDrug safetyDrugsEpidemiologyPharmacoepidemiologyPharmacogeneticsQuality of lifeSafety studies ePublished: 15 August 2000 Issue Published: 1 November 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Leona Baumgartner, MD, PhD
Authors: Preeti Malani
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A deletion map of the human immunoglobulin heavy chain variable region.
Authors: M A Walter, H M Dosch, D W Cox
Journal: The Journal of Experimental Medicine (1991)

Analysis of VH gene segments deleted in the process of immunoglobulin heavy chain (IGH) variable region assembly in three series of monoclonal B cell lines has been used to determine the human VH region organization. A deletion map of the relative positions of 21 different VH gene segments has been determined. The characterization of B cell lines from three unrelated adults of two racial groups yielded the same relative VH gene segment order, suggesting that the overall order of VH genes in the normal population is constant. This VH gene segment order was consistent with what we had previously generated from physical mapping techniques. DH segments from the second DH cluster, distinct from the major DH locus 3' of the VH region, were not observed to be used in 32 different rearrangements. Approximately 77% of the VH-(D)JH rearrangements involved VH gene segments within 500 kb of the JH region, indicating that human B cell lines preferentially rearrange JH-proximal VH gene segments. The switch, observed in mice, from the fetal use of JH-proximal VH gene segments to an adult VH use dependent upon VH family size may therefore not occur in humans. This detailed map of the VH gene segments is a necessary prerequisite for understanding VH usage in development and disease.
Recurrent haematuria: role of renal biopsy and investigative morbidity.
Authors: J Michael, N F Jones, D R Davies, J R Tighe
Journal: BMJ (1976)

The usefulness of renal biopsy in investigating unexplained haematuria was assessed by a study of 33 adults referred consecutively with this syndrome. Unequivocal abnormalities were seen on light microscopy or immunofluorescence in 31 of the 33 specimens of renal tissue examined. In 18 patients deposits of IgA were present in the mesangium. Loin pain occurred in only two of the 18 patients with mesangial IgA deposits, compared with 11 of the 15 patients without these deposits. Seven of the nine women in this series had had loin pain compared with only six of the 24 men. Thus a woman with loin pain and haematuria was not likely to have mesangial IgA nephropathy but this was found in 14 of the 18 men with unexplained painless haematuria. Failure to appreciate the role of renal biopsy in the investigation of unexplained haematuria may result in unnecessary radiology, considerable morbidity, and even in unjustified nephrectomy.
CCR3 is essential for skin eosinophilia and airway hyperresponsiveness in a murine model of allergic skin inflammation
Authors: Weilie Ma, Paul J. Bryce, Alison A. Humbles, Dhafer Laouini, Ali Yalcindag, Harri Alenius, Daniel S. Friend, Hans C. Oettgen, Craig Gerard, Raif S. Geha
Journal: Journal of Clinical Investigation (2002)

The CC chemokine receptor 3 (CCR3) is expressed by eosinophils, mast cells, and Th2 cells. We used CCR3–/– mice to assess the role of CCR3 in a murine model of allergic skin inflammation induced by repeated epicutaneous sensitization with ovalbumin (OVA), and characterized by eosinophil skin infiltration, local expression of Th2 cytokines, and airway hyperresponsiveness (AHR) to inhaled antigen. Eosinophils and the eosinophil product major basic protein were absent from the skin of sham and OVA-sensitized CCR3–/– mice. Mast cell numbers and expression of IL-4 mRNA were normal in skin of CCR3–/– mice, suggesting that CCR3 is not important for infiltration of the skin by mast cells and Th2 cells. CCR3–/– mice produced normal levels of OVA-specific IgE, and their splenocytes secreted normal amounts of IL-4 and IL-5 following in vitro stimulation with OVA, indicating effective generation of systemic Th2 helper responses. Recruitment of eosinophils to lung parenchyma and bronchoalveolar lavage (BAL) fluid was severely impaired in CCR3–/– mice, which failed to develop AHR to methacholine following antigen inhalation. These results suggest that CCR3 plays an essential role in eosinophil recruitment to the skin and the lung and in the development of AHR.
SPORADIC CEREBROSPINAL MENINGITIS; RECOVERY
Authors: George R. Green
Journal: JAMA (1913)

Nov. 3, 1912, I saw in consultation with Dr. F. E. Hill of this city Paul W., aged 12. The patient was comatose and had a high temperature; the neck and back muscles were stiff, and Kernig's sign was well marked. The pupils were dilated and the eyes staring. Fearing cerebrospinal meningitis I made a spinal puncture within an hour and withdrew 50 c.c. of milky spinal fluid, and, without withdrawing the exploring needle, I injected into the canal 30 c.c. of Flexner's serum. As soon as my son, Dr. E. S. Green, could reach our laboratory he made a careful microscopic examination and found the fluid loaded with the<i>Diplococcus intracellularis meningitidis</i>. In twenty-four hours I made a second puncture and again allowed 50 c.c. of spinal fluid to flow out and again injected 30 c.c. of Flexner's serum. Again Dr. E. S. Green made careful slides and found
Polymorphisms inside MicroRNAs and MicroRNA Target Sites Predict Clinical Outcomes in Prostate Cancer Patients Receiving Androgen-Deprivation Therapy
Authors: Bo-Ying Bao, Jiunn-Bey Pao, Chun-Nung Huang, Yeong-Shiau Pu, Ta-Yuan Chang, Yu-Hsuan Lan, Te-Ling Lu, Hong-Zin Lee, Shin-Hun Juang, Lu-Min Chen, Chi-Jeng Hsieh, Shu-Pin Huang
Journal: Clinical Cancer Research (2010)

Abstract Purpose: Recent evidence indicates that small noncoding RNA molecules, known as microRNAs (miRNAs), are involved in cancer initiation and progression. We hypothesized that genetic variations in miRNAs and miRNA target sites could be associated with the efficacy of androgen-deprivation therapy (ADT) in men with prostate cancer. Experimental Design: We systematically evaluated 61 common single nucleotide polymorphisms (SNPs) inside miRNAs and miRNA target sites in a cohort of 601 men with advanced prostate cancer treated with ADT. The prognostic significance of these SNPs on disease progression, prostate cancer-specific mortality (PCSM) and all-cause mortality (ACM) after ADT were assessed by Kaplan–Meier analysis and Cox regression model. Results: Four, seven, and four SNPs were significantly associated with disease progression, PCSM, and ACM, respectively, after ADT in univariate analysis. KIF3C rs6728684, CDON rs3737336, and IFI30 rs1045747 genotypes remained as significant predictors for disease progression; KIF3C rs6728684, PALLD rs1071738, GABRA1 rs998754, and SYT9 rs4351800 remained as significant predictors for PCSM; and SYT9 rs4351800 remained as a significant predictor for ACM in multivariate models that included clinicopathologic predictors. Moreover, strong combined genotype effects on disease progression and PCSM were also observed. Patients with a greater number of unfavorable genotypes had a shorter time to progression and worse prostate cancer-specific survival during ADT (P for trend &amp;lt; 0.001). Conclusion: SNPs inside miRNAs and miRNA target sites have a potential value to improve outcome prediction in prostate cancer patients receiving ADT. Clin Cancer Res; 17(4); 1–9. ©2010 AACR.
Tracheal Diverticulum and Congenital Oesophago-tracheal Fistula without Oesophageal Atresia
Authors: J. Mathey, A. Lemoine
Journal: Thorax (1954)

The first included the entire thickness of the oeso- phagus and was reinforced by a superficial invaginat- ing layer of sutures.The repair was difficult because the muscular layer was practically non-existent at the level of the fistula.The tracheal orifice was located
PRELIMINARY RESULTS WITH FLUPHENAZINE (PROLIXIN) IN CHRONIC PSYCHOTIC PATIENTS
Authors: JOHN P. HOLT, ELEANORE R. WRIGHT
Journal: American Journal of Psychiatry (1960)

Fluphenazine is a highly potent psychopharmacologic agent which is effective in controlling behavioral symptoms in chronic psychotic patients with the most pronounced changes manifested in reduced agitation and tension and improved socialization; the drug is also effective in controlling hallucinations and delusions. Through greater individualization of dosage may be required with fluphenazine than with other phenothiazines for maximum benefit with minimum reactions, fluphenazine appears to have great potential usefulness in the treatment of chronic psychotic patients.
Rescue of CD8 T cell–mediated antimicrobial immunity with a nonspecific inflammatory stimulus
Authors: Roman A. Tuma, Rielle Giannino, Patrick Guirnalda, Ingrid Leiner, Eric G. Pamer
Journal: Journal of Clinical Investigation (2002)

Reconstitution of protective immunity by adoptive transfer of pathogen-specific T cells has been successful in patients with compromised cellular immunity. The in vivo effectiveness of in vitro–expanded CD8 CTLs is variable, however. For example, adoptively transferred Listeria monocytogenes–specific CD8 CTLs only confer protective immunity if challenge infection occurs within 48 hours of T cell infusion. Herein we show that transferred CTLs persist in lymphoid compartments for many weeks, but that their response to bacterial challenge decreases during the first week following transfer. While T cells transferred less than 48 hours before infection proliferate, those transferred 7 days before infection die. Remarkably, treatment of mice with anti-CD40 at the time of T cell infusion reprograms transferred T cells, allowing them to proliferate and confer protective immunity upon bacterial challenge 7 days later. Our study demonstrates, for the first time to our knowledge that CD40-mediated stimuli can influence CD8 T cell activation independent of concurrent antigen exposure. The ability to modulate long-term responsiveness of CD8 T cells with a transient, nonspecific inflammatory stimulus has importation implications for adoptive immunotherapy.