<i>Helicobacter pylori</i> and Idiopathic Thrombocytopenic Purpura
Authors: Francesco Franceschi, Nicholas Christodoulides, Michael H. Kroll, Robert M. Genta
Journal: Annals of Internal Medicine (2004)

Letters4 May 2004Helicobacter pylori and Idiopathic Thrombocytopenic PurpuraFrancesco Franceschi, MD, Nicholas Christodoulides, PhD, Michael H. Kroll, MD, and Robert M. Genta, MDFrancesco Franceschi, MDFrom Catholic University of Rome, 00168 Rome, Italy; and Baylor College of Medicine and Veterans Affairs Medical Center, Houston, TX 77030., Nicholas Christodoulides, PhDFrom Catholic University of Rome, 00168 Rome, Italy; and Baylor College of Medicine and Veterans Affairs Medical Center, Houston, TX 77030., Michael H. Kroll, MDFrom Catholic University of Rome, 00168 Rome, Italy; and Baylor College of Medicine and Veterans Affairs Medical Center, Houston, TX 77030., and Robert M. Genta, MDFrom Catholic University of Rome, 00168 Rome, Italy; and Baylor College of Medicine and Veterans Affairs Medical Center, Houston, TX 77030.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-140-9-200405040-00028 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Background: Idiopathic thrombocytopenic purpura (ITP) is a hematologic disorder characterized by sensitization of platelets by autoantibodies leading to platelet destruction (1-4). Although its cause remains unclear, ITP is associated with several diseases, including infections (5-8).Helicobacter pylori, a gram-negative bacterium, is a frequent cause of upper gastrointestinal tract infection (9). Of interest, the presence of the cytotoxin-associated gene A (CagA), an important determinant of pathogenicity, is associated with greater gastric mucosal immune responses (9).Objective: In a previous study, we described increasing platelet counts in patients with ITP 4 months after eradication of CagA-positive H. pylori infection ...References1. Kelton JG. The serological investigation of patients with autoimmune thrombocytopenia. Thromb Haemost. 1995;74:228-33. [PMID: 8578463] CrossrefMedlineGoogle Scholar2. McMillan R. The pathogenesis of chronic immune (idiopathic) thrombocytopenic purpura. Semin Hematol. 2000;37:5-9. [PMID: 10676917] CrossrefMedlineGoogle Scholar3. Hou M, Stockelberg D, Kutti J, Wadenvik H. Immunoglobulins targeting both GPIIb/IIIa and GPIb/IX in chronic idiopathic thrombocytopenic purpura (ITP): evidence for at least two different IgG antibodies. Br J Haematol. 1997;98:64-7. [PMID: 9233565] CrossrefMedlineGoogle Scholar4. Kunicki TJ, Newman PJ. The molecular immunology of human platelet proteins. Blood. 1992;80:1386-404. [PMID: 1520866] CrossrefMedlineGoogle Scholar5. Romero R, Kleinman RE. Thrombocytopenia associated with acute hepatitis B infection. Pediatrics. 1993;91:150-2. [PMID: 8416484] MedlineGoogle Scholar6. Nagamine T, Ohtuka T, Takehara K, Arai T, Takagi H, Mori M. Thrombocytopenia associated with hepatitis C viral infection. J Hepatol. 1996;24:135-40. [PMID: 8907565] CrossrefMedlineGoogle Scholar7. Francois B, Trimoreau F, Vignon P, Fixe P, Praloran V, Gastinne H. Thrombocytopenia in the sepsis syndrome: role of hemophagocytosis and macrophage colony-stimulating factor. Am J Med. 1997;103:114-20. [PMID: 9274894] CrossrefMedlineGoogle Scholar8. Hohmann AW, Booth K, Peters V, Gordon DL, Comacchio RM. Common epitope on HIV p24 and human platelets. Lancet. 1993;342:1274-5. [PMID: 7694021] CrossrefMedlineGoogle Scholar9. Marshall BJ, Warren JR. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet. 1984;1:1311-5. [PMID: 6145023] CrossrefMedlineGoogle Scholar10. Gasbarrini A, Franceschi F, Tartaglione R, Landolfi R, Pola P, Gasbarrini G. Regression of autoimmune thrombocytopenia after eradication of Helicobacter pylori [Letter]. Lancet. 1998;352:878. [PMID: 9742983] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Francesco Franceschi, MD; Nicholas Christodoulides, PhD; Michael H. Kroll, MD; Robert M. Genta, MDAffiliations: From Catholic University of Rome, 00168 Rome, Italy; and Baylor College of Medicine and Veterans Affairs Medical Center, Houston, TX 77030. 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Pylori Infection Play a Role in Idiopathic Thrombocytopenic Purpura and in Other Autoimmune Diseases?Co-existence of Helicobacter pylori infection in patients with Familial Mediterranean Fever (FMF) and the effect of Helicobacter pylori on the frequency and severity of FMF attacksHelicobacter pylori eradication: Novel therapy for immune thrombocytopenic purpura? A review of the literatureThrombotic thrombocytopenic purpura: Proposal of a new pathogenic mechanism involving Helicobacter pylori infectionHelicobacter pylori and Idiopathic Thrombocytopenic PurpuraGiovanni Emilia, MD, Mario Luppi, MD, and Giuseppe Torelli, MD 4 May 2004Volume 140, Issue 9Page: 766-767KeywordsAntibodiesAntibody therapyAntigensArteriesHelicobacter pyloriIdiopathic thrombocytopenic purpuraPatientsPlateletsSmooth musclesSodium ePublished: 4 May 2004 Issue Published: 4 May 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...