tbuckley/cabot-search huggingface dataset:
More Privacy, Less Support
Authors: W. J. MULLIGAN
Journal: Annals of Internal Medicine (1981)

Letters1 June 1981More Privacy, Less SupportW. J. MULLIGAN, M.D.W. J. MULLIGAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-94-6-824 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: For centuries a traditional inpatient facility for the care of the sick has existed. Great hospitals throughout Europe and the United States had, as the central place of care, open wards where segregation was established by race, sex, illness, and social factors. Eventually this dichotomy was perceived as an inequity: poor people were cared for on the wards whereas wealthy people had private and semiprivate rooms. We are watching an era end, for now we construct hospitals to insure privacy. Some rooms are semiprivate but many are private, with all the rights and privileges thereunto appertaining. Now... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: W. J. MULLIGAN, M.D.Affiliations: Kino Community Hospital Tucson AZ 85713 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1981Volume 94, Issue 6Page: 824-824KeywordsInpatientsRacial and ethnic issues ePublished: 1 December 2008 Issue Published: 1 June 1981 PDF downloadLoading ...
Cholesterol Screening: Hits and Misses-Reply
Authors: Stephen Havas
Journal: JAMA (1991)

In Reply.  —I agree with Dr and Ms Record concerning the important role that public screening programs can play in educating the public concerning high blood cholesterol values. The important work of the Records in community-based control programs for high blood pressure and high blood cholesterol in Maine is well recognized in New England. The results reported in their letter provide further evidence of their good work.  Blood pressure screening programs conducted throughout the United States in the 1970s and 1980s were a major contributing force to the improved awareness and control of high blood pressure that occurred during that period. The attendant reductions in morbidity and mortality from cardiovascular diseases indicate the enormous potential of such programs.  I hope cholesterol screening programs will make similar contributions. They are, however, far more complex undertakings than blood pressure screenings because of the greater difficulty in producing accurate and precise results and
Systemic Effects of Nitrofurazone-Impregnated Urinary Catheters in Trauma Patients
Authors: William A. Stinnette
Journal: Annals of Internal Medicine (2008)

Letters18 March 2008Systemic Effects of Nitrofurazone-Impregnated Urinary Catheters in Trauma PatientsWilliam A. Stinnette, MDWilliam A. Stinnette, MDFrom Kaiser Permanente, San Rafael, CA 94903.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-148-6-200803180-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I read with interest the article by Stensballe and colleagues (1) on the infection risk of nitrofurazone-impregnated urinary catheters in trauma patients. I wondered whether any evidence suggested systemic absorption and associated adverse effects related to nitrofurantoin, such as anemia, liver abnormalities, and respiratory difficulties (including lung injury)?William A. Stinnette, MDKaiser PermanenteSan Rafael, CA 94903Reference1. Stensballe J, Tvede M, Looms D, Lippert FK, Dahl B, Tønnesen E, et al. Infection risk with nitrofurazone-impregnated urinary catheters in trauma patients: a randomized trial. Ann Intern Med. 2007;147:285-93. [PMID: 17785483] LinkGoogle Scholar Author, Article, and Disclosure InformationAuthors: William A. Stinnette, MDAffiliations: From Kaiser Permanente, San Rafael, CA 94903.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoInfection Risk with Nitrofurazone-Impregnated Urinary Catheters in Trauma Patients Jakob Stensballe , Michael Tvede , Dagnia Looms , Freddy Knudsen Lippert , Benny Dahl , Else Tønnesen , and Lars Simon Rasmussen Systemic Effects of Nitrofurazone-Impregnated Urinary Catheters in Trauma Patients Jakob Stensballe Metrics 18 March 2008Volume 148, Issue 6Page: 486KeywordsAnemiaCathetersConflicts of interestLiverLungsUrinary tract infections ePublished: 18 March 2008 Issue Published: 18 March 2008 Copyright & PermissionsCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Blood pressure response to percutaneous transluminal angioplasty for renovascular hypertension: an overview of published series.
Authors: L E Ramsay, P C Waller
Journal: BMJ (1990)

To evaluate the efficacy and safety of transluminal angioplasty in the treatment of renovascular hypertension.Overview of 10 published case series.Mostly tertiary referral centres.691 Patients treated by angioplasty for renovascular hypertension, 464 for atherosclerotic stenosis, 193 for fibromuscular stenosis, and the remainder mainly for post-transplant stenosis. The inclusion criteria varied considerably between studies.Percutaneous transluminal renal artery angioplasty (successful or attempted); prophylaxis against restenosis in most cases. Policies on antihypertensive drug treatment and follow up varied.Blood pressure response as defined in the individual papers, with each patient classified as either cured, improved, or failed. Each study used a different definition of improvement in blood pressure. Complication rates.Follow up data were available for 670 patients. The procedure was technically successful in 611 patients (88%). The overall cure rate for hypertension was 24% (163 patients) and a further 43% (286) were "improved." There were large and significant variations between studies in the rate of technical success and also the blood pressure outcome. In each series patients with fibromuscular lesions, had a higher cure rate than those with atherosclerotic lesions (overall cure 50% v 19% odds ratio 3.9, 95% confidence interval 2.6 to 6.0). Complications were reported in 63 (9%) patients and three patients died (0.4%).The evidence for the value of angioplasty in treating renovascular hypertension has serious limitations. Angioplasty for fibromuscular disease seems to be worth while, but for atherosclerotic lesions the benefit appears to be small and its efficacy needs to be compared with medical therapy in randomised trials. These findings emphasise the importance of early formal evaluation of new therapeutic techniques.
Hydrocephalic Fetus Delivered by Spinal Tapping
Authors: J. W. Ballantyne
Journal: BMJ (1904)

THE delivery of the after-coming head is often a matter requiring skilful manipulation, and the employment of the forceps is sometimes necessary.If, however, the head happen to be hydrocephalic as well as after-coming, the most careful manipulation will often fail to deliver it, and the use .offorceps becomes a danger.The value of the method suggested by Van Huevel and carried out by Tarnier will under these circumstances be easily appreciated.As that method does not appear to be widely known or often prac- tised in this country, it has seemed to me that the report of the following case may serve a useful purpose in bringing it prominently before the profession.'On the night of August 15th I was hurriedly summoned to the Royal.Maternity Hospital, Dr. Hy. H. Robarts, one of the resident surgeons, informing me by telephone that a woman was being sent in with her baby born as far as the shoulders, but with the head still above the pelvic brim.On my arrival at the hospital I was put in possession of the following facts regarding the case: The patient was a married woman, 28 years of age, who had had three previous confinements
NATIONAL LICENSURE FOR PHYSICIANS IN THE FEDERAL SERVICE
Authors: Eugene C. Lowe
Journal: JAMA (1918)

<h3>To the Editor:</h3> —Will you kindly inform me whether a medical officer of the U. S. Navy would be given a license to practice in civil life without taking the various state board examinations and, if this privilege is not extended by all the states, whether it is extended by any and, if so, which? In view of the rigid examinations necessary to pass in order to get a commission in the regular corps of the Navy and Army, it appeals to my mind that the states would be perfectly justified in assuming that all medical officers are mentally qualified and entitled to a certificate to practice and to obtain a license. [Comment.—The above letters are samples of many received byThe Journal. The regulation of medical practice comes under the police powers of the state; the only way to accomplish what our correspondents desire is to secure favorable
T LYMPHOCYTES OF RHEUMATOID ARTHRITIS PATIENTS SHOW AUGMENTED REACTIVITY TO A FRACTION OF MYCOBACTERIA CROSS-REACTIVE WITH CARTILAGE
Authors: Joseph Holoshitz, Abraham Klajman, Ilana Drucker, Zvi Lapidot, Avraham Yaretzky, Ayala Frenkel, Willem Van Eden, IrunR. Cohen
Journal: The Lancet (1986)
Relative Weight, Height, and Risk of Breast Cancer-Reply
Authors: W. C. Willett
Journal: JAMA (1990)

<h3>In Reply.—</h3> Drs Albanes and Brown raise concern about confounding by height in our study because we used BMI at weight divided by height raised to the second power rather than as weight divided by height to the 1.5 power. No appreciable confounding could occur because the correlation between height and BMI is -.03 in our study. Even if the relation between height and BMI was similar to that in his study (<i>r</i>= -. 12), our results still would not be appreciably distorted as the association of height and breast cancer was very weak (for extreme categories, the relative risk was 1.1 in premenopausal women and 1.3 in postmenopausal women). The emphasis on uncorrelatedness with height as a criterion for an obesity index is an anachronism from before the computer era. The primary criterion should be maximal correlation with either absolute or relative body fat mass; there is no evidence that
Reviews and Notes: Pulmonar Disease: Occupational and Environmental Respiratory Disease
Authors: Howard Frumkin
Journal: Annals of Internal Medicine (1996)

Literature of Medicine15 March 1996Reviews and Notes: Pulmonar Disease: Occupational and Environmental Respiratory DiseaseHoward Frumkin, MD, DrPHHoward Frumkin, MD, DrPHEmory University; Atlanta, GA 30322Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-124-6-199603150-00028 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail P Harber, MB Schenker, and JR Balmes; eds. 1038 pages. St. Louis: Mosby; 1996. $139.00. ISBN 0-8016-7728-9. Order phone 800-426-4545.For at least 24 centuries, since Hippocrates wrote his treatise Air, Waters, Places, we have appreciated that inhalants can affect pulmonary health. The last few years have seen a profusion of books on various aspects of occupational and environmental lung disease; entire books address subdisciplines, such as radiology and pathology, and specific exposures, such as asbestos and beryllium. We now have yet another major text that surveys the entire field, joining two standard texts—Parkes' Occupational Lung Disorders (1994) and Morgan ... Author, Article, and Disclosure InformationAffiliations: Emory University; Atlanta, GA 30322 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 March 1996Volume 124, Issue 6Page: 617-618KeywordsLibrariesLungsOccupational asthmaPneumoconiosesPneumonitisPrevention, policy, and public healthPulmonary diseasesRespiratorsSilicosisVentilators ePublished: 15 August 2000 Issue Published: 15 March 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Effects of PBBs on cattle. I. Clinical evaluations and clinical chemistry.
Authors: H I Durst, L B Willett, F L Schanbacher, P D Moorhead
Journal: Environmental Health Perspectives (1978)

Toxicosis was induced in pregnant heifers by feeding 25,000 mg/head/day of FireMaster BP-6, a commercial blend of polybrominated biphenyls (PBB). The PBB feeding decreased dry matter intake approximately 50% by 4 days exposure. Emaciated animals became anorexic a few days prior to death at 33 to 66 days. Weight losses of heifers average 80 kg. Other clinical signs observed were dehydration, diarrhea, excessive salivation and lacrimation, fetal death, abortion, and general depression as evidenced by depressed heart and respiratory rates. Clinical signs were apparent after 10 days exposure and progressively intensified along with loss of condition until death. Clinicopathologic changes included significantly increased serum glutamic-oxaloacetic transaminase and decreased serum calcium by 30 days exposure. Lactate dehydrogenase, urea nitrogen, and bilirubin were elevated, and serum albumin decreased by 36 to 40 days. Principal urine changes were decreased specific gravity and moderate proteinuria. Pregnant heifers fed 0.25 or 250 mg/head/day for 60 days and nonpregnant heifers fed 250 mg/head/day for 180 days displayed neither clinical signs nor clinicopathologic changes indicating adverse effects from PBB exposure. Post-exposure, all heifers exposed to PBB for 60 days calved normally with zero calf mortality and were successfully rebred. Milk production was not different from control animals. Birth weights of calves from dams exposed to 250 mg PBB/head/day were significantly greater than calves of dams exposed to 0 mg or 0.25 mg/head/day. PBB exposure of dams produced no detrimental effects on calves as indicated by clinical signs, clinicopathologic changes, or performance.
Thyroid Physiology in Health and Disease
Authors: JOSIAH BROWN
Journal: Annals of Internal Medicine (1974)

The pituitary thyrotrophin reserve in 55 patients was tested with thyrotrophin-releasing hormone, and only 28% with deficient responses were hypothyroid; in three patients with hypothalamic disorders the response was delayed but otherwise normal. Three pituitary hormones, thyrotrophin, luteinizing hormone, and follicle-stimulating hormone, contain the same alpha polypeptide chain but different beta chains that confer specificity. Although the serum triiodothyronine (T3) concentration is 1/75th that of thyroxine (T4), its greater volume of distribution (threefold) and disappearance rate (sixfold) results in a T3 turnover one third to one fourth that of T4. Approximately 20% to 33% of T3 comes from the thyroid gland, the remainder from T4. But T4, a prohormone for T3, also contributes hormonal effects. The features of Graves' disease suggest it is an autoimmune disorder, but long-acting thyroid stimulator does not correlate with level or control of thyroid function. The serum thyroglobulin level is higher in women (6.0 ng/ml) than men (3.4 ng/ml); the levels are stable, higher in the newborn than in their mothers; and they rise after thyroid stimulation and fall after suppression. Thyroglobulin levels are elevated during active subacute thyroiditis and are persistently high in hyperthyroidism.
Relation of Atrial Refractoriness to Upper and Lower Limits of Vulnerability for Atrial Fibrillation/Flutter Following Implantable Ventricular Defibrillator Shocks
Authors: Amos Katz, Robert J. Sweeney, Robert M. Gill, Philip R. Reid, Eric N. Prystowsky
Journal: Circulation (1999)

Background —Implantable ventricular cardioverter defibrillator (ICD) shocks can cause atrial fibrillation/flutter (AF). This study investigated the pathogenesis of AF after ICD shocks in a canine model. Methods and Results —The study was conducted in 8 dogs. In 5 dogs (group 1), truncated exponential (8 ms, 78% tilt) monophasic and biphasic shocks were delivered through a bipolar epicardial (patch) or endocardial lead. After the last S1 of atrial pacing at a cycle length of 350 ms, shocks of 0.1 to 7.6 A (0.005 to 27.7 J) were delivered, timed to the atrial effective refractory period (AERP). Ventricular defibrillation thresholds were also determined. In 3 dogs (group 2), the effect of the open versus closed chest technique on AF induction was tested in the endocardial biphasic shock configuration. AF was induced in all 8 dogs and in all waveforms and configurations. Mean AF duration was 11.5±6 s, with a mean ventricular rate of 184±37 bpm. Ventricular shocks could induce AF only if they were timed between an AERP of −60 to 40 ms, −40 to 60 ms, −40 to 60 ms, and −20 to 60 ms in the epicardial monophasic, epicardial biphasic, endocardial monophasic, and endocardial biphasic configurations, respectively. The mean±SD of the upper limit of vulnerability (ULV) for AF induction (in J) was 5.2±0.6, 3.5±0.4, 5.2±1.2, and 2.5±0.1 for the epicardial monophasic, epicardial biphasic, endocardial monophasic, and endocardial biphasic configurations, respectively ( P &lt;0.05). The lower limit of vulnerability (LLV) was 0.8±0.1, 0.8±0.1, 0.9±0, and 0.6±0 for the epicardial monophasic, epicardial biphasic, endocardial monophasic, and endocardial biphasic configurations, respectively ( P =NS). The ventricular defibrillation threshold (in J) for all wave forms and configurations was higher than the ULV ( P &lt;0.05). Conclusions —(1) An atrial LLV and ULV exist for ventricular ICD shock–induced AF; (2) the shock-induced AF is related to both shock intensity and its timing to AERP; and (3) avoiding this atrial window of vulnerability may minimize the risk of post-ICD shock AF.
Diagnosis of Mycoplasma pneumoniae Infection-Reply
Authors: Parimal K. Ghatak
Journal: JAMA (1977)

We acknowledge a misprint in our case report; the sentence should read Streptococcusantibody was present (in the serum) in a dilution of 1:128.  The questions raised by Dr Lind can be easily dismissed by a look into the published literature on the subject. A high titer of CA usually indicatesMycoplasma pneumoniaeinfection.1-3A fourfold rise in the titer of CA is a feature ofMycoplasmainfection (191:369,1965).3-6The titer of CA in infections other thanMycoplasmais usually low.4The severity of illness fromMycoplasma pneumoniaeinfection was not correlated with CA titer (191:369, 1965). We did not postulate the mechanism of CA production inMycoplasma pneumoniaeinfection; there are several articles in publication on this topic.4,7,8Discrepancy of positive results between specific antibody titer by immunofluorescence and complement fixation test ofMycoplasma pneumoniaeis a result of the inheritant nature of
An Apple for the Doctor
Authors: Lorenzo G. Guzman
Journal: JAMA (1985)

It had been a particularly vexing and difficult day. It was my birthday, and I was on the orthopedic surgery rotation of my general surgery residency. A few months before, the nursing personnel and the operating room supervisor had presented the chief resident on his birthday with a large ice cream cake and several useful gifts. I had taken careful notes and, when the time came, adeptly dropped a few casual remarks about my forthcoming birthday, making sure the exact date was properly fixed in the right people's minds. The day came and there was no cake, no gifts, not even a remembrance or greeting card from anyone. I had had to assist in the operating room, first with a laborious hemipelvectomy, then with the repair of a torn shoulder rotator cuff, which had started long after the usual hour for planned surgical procedures. I misplaced the key to my
Brief Buprenorphine Detox Effective for Some Opioid-Dependent Patients
Authors: Anita Slomski
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract C12: EGFR signaling controls the chromatin binding status of BMI1 through a CK2/PP1 phosphorylation/dephosphorylation pathway and affects astrocytoma proliferation and neural stem cell differentiation
Authors: Jessica H. Hawes, Robert G. Tuskan, Keiko Agaki, Karlyne M. Reilly
Journal: Cancer Research (2009)

Abstract Studies of brain tumors demonstrate the importance of a rare tumor cell population with the capability of regenerating tumors upon transplantation. These cancer stem cells (CSC) are believed to be more resistant to therapy than the bulk of brain tumor cells. Studies in mouse brain tumor models demonstrate that neural stem cells (NSC) can be an important initiating cell type for brain tumors, but the relationship between NSC and CSC is unclear. EGF is a critical growth factor for NSC maintenance in culture and EGFR signaling is upregulated in glioblastoma. Similarly, the chromatin modulator BMI1 is necessary for NSC maintenance, and has been implicated in glioblastoma. We present studies linking cell surface EGF signaling and nuclear BMI1 chromatin binding. We demonstrate that BMI1 is specifically phosphorylated by EGFR signaling using EGF and TGFα, but not by other ligands tested. We have identified three amino acids encompassing the phosphorylation site in response to EGFR signaling, and show that CK2 and PP1 are necessary for control of BMI1 phosphorylation. This phosphorylation alters the chromatin binding state of BMI1 and transcriptional regulation in astrocytoma cells. Interestingly we find that BMI1 can alter transcriptional profiles in both EGF-dependent and independent ways, suggesting that different signaling pathways could have specific effects on changing the BMI1-dependent epigenetic state of subsets of genes. Furthermore, EGF-induced phosphorylation of BMI1 is important for astrocytoma growth in vitro and in vivo, as well as maintenance of NSC. Our data link signals outside the cell to the nucleus important for NSC maintenance and astrocytoma proliferation. These data represent a common pathway in NSC and CSC that may explain the importance of EGF signaling for NSC maintenance and gliomagenesis, and suggest a novel downstream pathway (CK2/PP1) involved in these processes. Citation Information: Cancer Res 2009;69(23 Suppl):C12.