tbuckley/cabot-search huggingface dataset:
Letters to patients: sending the right message
Authors: P. E M Smith
Journal: BMJ (2002)

Ihad described her in my letter as “enmeshed with her mother,” although I had kept this opinion to myself during the consultation. It was a trivial and unnecessary remark, which added nothing to the diagnosis or management plan. Her general practitioner, embarrassed for me, refused her mother's request for a copy of the letter. Eventually, of course, she obtained one and was understandably annoyed by the attempted cover up. My throwaway line had damaged my relationship with the patient, but more importantly had strained the trust between her GP and the family. I resolved then that my clinic letters would report the consultation solely, would include only narrative and comments openly discussed, and would be copied to the patient.

> There is no room for the jokes and smart remarks that used to entertain us 

Copying medical correspondence to patients is increasingly practised and the inquiry report into children's heart surgery at the Bristol Royal Infirmary recommends it …
Acute Anxiety and Hysteria
Authors: G. Garmany
Journal: BMJ (1955)

Anxiety is an abnormal emotion which resembles fear subjectively but differs from it in its persistence when the cause of the emotion is no longer apparent to the patient or appears inadequate to account for the symp- toms experienced.It is abnormal by the criteria we apply to illness generally-namely, that the patient is called to bear an unreasonable amount of discomfort and is disabled to a varying degree in his work and in his capacity to maintain satisfactory social relationships.Thus the definition of the term excludes the normal or physiological response to the buffets of everyday life, and in practice there is no difficulty in distinguishing the two.A distinction must also be made between anxiety the symptom, which may colour a number of syndromes, and the anxiety state, which is a fairly clearly demarcated syndrome with anxiety as its principal symptom.When anxiety is very severe it overflows into the muscular system, with the production of gross motor
The Transcriptional Coregulators TIF2 and SRC-1 Regulate Energy Homeostasis by Modulating Mitochondrial Respiration in Skeletal Muscles
Authors: Delphine Duteil, Céline Chambon, Faisal Ali, Rocco Malivindi, Joffrey Zoll, Shigeaki Kato, Bernard Geny, Pierre Chambon, Daniel Metzger
Journal: Cell Metabolism (2010)
Arcus Senilis in Middle-aged Men
Authors: G. M. McAndrew, D. Ogston
Journal: BMJ (1965)

Myocardial Infarction-Stuart et al. w 425 myocardial infarction, 40 patients with ischaemic cardiac disease, and 24 patients with other conditions.S.H.B.D. values were found to be elevated, often markedly, at some stage in every patient with recent myocardial infarction.Smaller elevations were found in some patients with myocardial ischaemia, pulmonary infarction, pneumonia, or bronchitis.An S.H.B.D. value of 140 units/l.has been chosen as the most appropriate value for differentiating between recent myo- cardial infarction and other conditions, including myocardial ischaemia.In 9 out of 10 patients with myocardial infarction S.H.B.D. results are above this level at some stage within three days of the acute episode, and the elevation persists for 10 days in four patients out of five.This is of particular diagnostic value when the patient is admitted some days after the event.The diagnostic efficiency of S.H.B.D. determination is greater than that of S.G.O.T. determination, especially in the period 3 to 10 days after the acute episode, and compares favourably with that of the E.C.G.S.H.B.D. values after myocardial infarction appear to be of little prognostic value.We should like to thank the various physicians who have allowed us to study patients under their care.We are grateful to Dr. M. F. Oliver for his helpful criticism during this study, and to Dr.
Dose-response effect of sodium cromoglycate pressurised aerosol in exercise induced asthma.
Authors: W M Tullett, K M Tan, R T Wall, K R Patel
Journal: Thorax (1985)

The effects of 2, 10, and 20 mg of sodium cromoglycate delivered by aerosol were compared with those of placebo in a double blind study in 11 patients with extrinsic and exercise induced asthma. The effect of nebulised sodium cromoglycate delivered through a Wright nebuliser (estimated dose 12 mg) was also studied. Patients exercised on a treadmill for six to eight minutes at submaximal work loads on five days, 30 minutes after inhaling placebo or sodium cromoglycate. The FEV1 was recorded before treatment, before exercise, and up to 30 minutes after exercise. Mean baseline values of FEV1 before and after placebo or sodium cromoglycate did not differ significantly on the five days. After exercise the mean (SEM) maximal percentage fall in FEV1 after placebo; 12 mg sodium cromoglycate nebuliser solution; and 2, 10, and 20 mg sodium cromoglycate aerosol were 31.1 (3.8); 9.4 (2.1); and 19.4 (4.6), 13.7 (3.5), and 9.4 (1.9). Sodium cromoglycate inhibited exercise induced asthma at all doses used; the protective effect of the aerosol increased from 2 to 20 mg. The protective effect of 20 mg sodium cromoglycate aerosol was similar to that seen with 12 mg nebulised solution. Our results suggest that the effect of sodium cromoglycate aerosol in exercise induced asthma is dose related.
Model study of flow in curved and planar arterial bifurcations
Authors: J. R BATTEN, R. M NEREM
Journal: Cardiovascular Research (1982)

Velocity profile measurements have been made for steady and pulsatile flow within rigid tube models of a curved and a planar arterial bifurcation with the intent of providing some insight into the fluid mechanical forces existing at such branches. An example in the cardiovascular system of a curved bifurcation is the branching of the left common coronary artery into the left circumflex and left anterior descending coronary arteries where the vessels curve over the base of the heart and an example of a planar bifurcation is the branching of the abdominal aorta into the left and right iliac arteries. Point velocity measurements were carried out using a constant temperature hot-film anemometer system.
Resident Physician Performance in a Continuing Education Format
Authors: Ronald E. Pinkerton
Journal: JAMA (1980)

As part of an educational program in preventive dentistry for family medicine residents, we evaluated changes in systemic fluoride prescribing habits related to newly acquired knowledge. Residents, unaware of the study, were randomly assigned to one of two groups and shown a videotape describing preventive dental techniques. We supplemented the tape viewed by one group with specific instructions explaining the implementation of the information in patient care. Residents in both groups demonstrated the ability to learn and maintain their level of knowledge during a three-month period. Daily chart audits, however, revealed no substantial increase in correct prescribing of systemic fluoride to pediatric patients for either group. Only subsequent individual monitoring and reinforcement achieved the desired behavior. The acquisition of new knowledge by resident physicians under these circumstances did not lead to its application in daily patient care. This result parallels reported difficulties in altering physician behavior by continuing medical education, and suggests that residency programs are an appropriate setting to initiate improved physician performance in response to acquired knowledge.
US toughens warning on power morcellators
Authors: M. McCarthy
Journal: BMJ (2014)

The US Food and Drug Administration has toughened its stance on laparoscopic power morcellators, warning doctors not to use the devices in the vast majority of hysterectomy and myomectomy procedures because of a risk that they can spread cancer cells in the abdomen.1

Power morcellators use rapidly spinning blades to cut uterine tissue into fragments that can be easily removed through a small incision. The term comes from the French morceler —to break into pieces. The devices are popular with surgeons because patients tend to recover more quickly when smaller incisions are used, but if the morcellator encounters an undetected uterine sarcoma during the procedure there is a risk that its spinning blades will seed the abdomen with tumor tissue. The FDA has estimated that about 1 in 350 women undergoing hysterectomy or myomectomy for fibroids has an unsuspected uterine sarcoma.

William …
Palliative and End-of-Life Care in the African American Community
Authors: LaVera Crawley
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Does Infection with Human Immunodeficiency Virus Affect the Antibody Responses to Plasmodium falciparum Antigenic Determinants in Asymptomatic Pregnant Women?
Authors: J.G. Ayisi, OraLee H. Branch, A. Rafi-Janajreh, A.M. van Eijk, F.O. ter Kuile, D.H. Rosen, P.A. Kager, D.E. Lanar, A. Barbosa, D. Kaslow, B.L. Nahlen, A.A. Lal
Journal: Journal of Infection (2003)
Characterization and inhibition of β-adrenergic receptor kinase in intact myocytes
Authors: Karl-Ludwig Laugwitz, Kai Kronsbein, Manfred Schmitt, Katrin Hoffmann, Melchior Seyfarth, Albert Schömig, Martin Ungerer
Journal: Cardiovascular Research (1997)

beta-Adrenergic receptor kinase (beta ARK) phosphorylates and thereby inactivates agonist-occupied beta-adrenergic receptors (beta AR). beta ARK is thought to play an important role in the regulation of cardiac function. Therefore, we studied beta ARK activation and its inhibition in intact smooth muscle cells and in cardiomyoblasts.beta AR agonist-stimulated translocation of beta ARK was monitored by immunofluorescence labelling with specific antibodies and confocal laser scanning microscopy in DDT-MF 2 hamster smooth muscle cells and in H9c2 rat cardiomyoblasts. In unstimulated cells. beta ARK was mainly located in the cytosol. After beta AR agonist stimulation, the beta ARK signal was partially translocated to the membranes. Liposomal gene transfer of the COOH-terminus of beta ARK ('beta ARKmini') as a beta ARK inhibitor led to functional expression of this protein in both cell lines with high efficiency. Western blots with beta ARK antibodies showed a gene concentration-dependent immunoreactivity of the 'beta ARKmini' protein. 'beta ARKmini'-transfected myocytes demonstrated reduced membrane targeting of the beta ARK immuno-fluorescence signal. Additionally, the effect of 'beta ARKmini' on beta AR-induced desensitization of myocytic cAMP accumulation was investigated. In control cells, desensitization with isoproterenol led to a subsequent reduction of beta AR-induced cAMP accumulation. In 'beta ARKmini'-transfected myocytes, this beta AR-induced desensitization was significantly diminished, whereas normal beta AR-induced cAMP accumulation was unaffected. A gene concentration of 2 micrograms 'beta ARKmini' DNA/100,000 cardiomyoblasts, and of 0.7 microgram 'beta ARKmini' DNA/100,000 DDT-MF2 smooth muscle cells led to approximately 5.9- and approximately 5.6-fold overexpressions of 'beta ARKmini' vs. native beta ARK, respectively. These gene doses proved sufficient to attenuate beta-adrenergic desensitization significantly.(1) beta ARK translocation was evidenced in DDT-MF2 smooth muscle cells and in cardiomyoblasts by confocal laser scanning microscopy. (2) Feasibility of 'beta ARKmini' gene transfer to myocytes was demonstrated, and necessary gene doses for beta ARK inhibition were titered. (3) Overexpression of 'beta ARKmini' functionally interacted with endogenous beta-adrenergic signal transduction, leading to sustained cAMP accumulation after prolonged beta-adrenergic stimulation.
Groping for Causation
Authors: Samuel Vaisrub
Journal: JAMA (1979)

Multifactorial is fast becoming a vogue word in medicine.Dorland's Medical Dictionarydefines it as  or pertaining to, or arising through the action of many factors. Curiously, the term has not as yet found its way toWebster's, Random House, andAmerican Heritage. Whether this neologism is a welcome addition to the language of medicine depends to a degree on one's concepts of causality.  Causality, of course, is not an exclusively medical concern. It is the central doctrine of the laws of physics and one of the main preoccupations of philosophers since ancient times. Aristotle's four causes (essential, formal, exciting, and final) dominated Western thought for centuries. They served as points of reference even when philosophers departed from the traditional Aristotelian formulation to formulate their own.  As various concepts of causality passed through the focusing prisms of medical philosophers, they underwent further changes to accommodate the need for understanding
Autoantibody selection and production in early human life
Authors: Eric Meffre, Jane E. Salmon
Journal: Journal of Clinical Investigation (2007)

Natural antibodies are autoreactive/polyreactive antibodies believed to be secreted in the absence of xenoantigens. The origin and functional role of this limited and selective autoimmunity are not clear, nor is the specificity and range of autoantigens that drive the development of B cells producing natural antibodies. In this issue of the JCI, Merbl et al. report that in utero, humans generate natural IgM and IgA antibodies that recognize a uniform set of autoantigens (see the related article beginning on page 712), some of which are associated with autoimmune diseases. The authors postulate that this "autoimmunity" at birth favors the emergence of autoimmune diseases in later life. We present a molecular basis for the limited and common repertoire of antibodies produced by fetal B cells, which may be distinct from the abnormalities in B cell development described in patients with autoimmune diseases.
MicroRNA-15a and MicroRNA-16 Impair Human Circulating Proangiogenic Cell Functions and Are Increased in the Proangiogenic Cells and Serum of Patients With Critical Limb Ischemia
Authors: Gaia Spinetti, Orazio Fortunato, Andrea Caporali, Saran Shantikumar, Micol Marchetti, Marco Meloni, Betty Descamps, Ilaria Floris, Elena Sangalli, Rosa Vono, Ezio Faglia, Claudia Specchia, Gianfranco Pintus, Paolo Madeddu, Costanza Emanueli
Journal: Circulation Research (2012)

Circulating proangiogenic cells (PACs) support postischemic neovascularization. Cardiovascular disease and diabetes mellitus impair PAC regenerative capacities via molecular mechanisms that are not fully known. We hypothesize a role for microRNAs (miRs). Circulating miRs are currently investigated as potential diagnostic and prognostic biomarkers.
Cellular Transmission of Mouse Sarcomata with Frozen-dried Tumour Tissues
Authors: L. Dmochowski, A. Millard
Journal: BMJ (1950)

TUMOUR TISSUES BrmOL grow in tissue culture, but induced tumours in mice.This is probably due to the more favourable conditions in vivo, which offer better chances of recovery for the treated tumour cells than does the environment in vitro; it suggests that successful growth in tissue culture depends on the length of time of desiccation.Although the degree of desiccation reached after 75 minutes may be high, it is realized that dehydration is not complete.If the time of desiccation is more prolonged only few, if any, cells can be expected to survive.It seems that three stages in the behaviour of tumour cells following different lengths of desiccation can be distinguished: (1) positive growth in vitro and in vivo;
Workgroup Report: Developing Environmental Health Indicators for European Children: World Health Organization Working Group
Authors: Kathy Pond, Rokho Kim, Maria-Jose Carroquino, Philippe Pirard, Fiona Gore, Alexandra Cucu, Leda Nemer, Morag MacKay, Greta Smedje, Antonis Georgellis, Dafina Dalbokova, Michal Krzyzanowski
Journal: Environmental Health Perspectives (2007)

A working group coordinated by the World Health Organization developed a set of indicators to protect children's health from environmental risks and to support current and future European policy needs. On the basis of identified policy needs, the group developed a core set of 29 indicators for implementation plus an extended set of eight additional indicators for future development, focusing on exposure, health effects, and action. As far as possible, the indicators were designed to use existing information and are flexible enough to be developed further to meet the needs of policy makers and changing health priorities. These indicators cover most of the priority topic areas specified in the Children's Environment and Health Action Plan for Europe (CEHAPE) as adopted in the Fourth Ministerial Conference on Health and Environment in 2004, and will be used to monitor the implementation of CEHAPE. This effort can be viewed as an integral part of the Global Initiative on Children's Environmental Health Indicators, launched at the World Summit on Sustainable Development in 2002.
Surface Tension Phenomena in Human Atelectasis.
Authors: A. I. Sutnick
Journal: Annals of Internal Medicine (1963)

s1 April 1963Surface Tension Phenomena in Human Atelectasis.A. I. Sutnick, M.D., L. A. Soloff, M.D., F.A.C.P.A. I. Sutnick, M.D.Search for more papers by this author, L. A. Soloff, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-4-739_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA lipoprotein substance which lines the alveolar membrane has assumed considerable importance in respiratory mechanics by its ability to lower surface tension as surface area decreases. Studies of human lung tissue have been few, but have suggested that a deficiency of or an antagonist to this surfactant exists in the lungs of patients dying of pulmonary hyaline membrane disease, atelectasis neonatorum, and following prolonged extracorporeal perfusion. We have examined the surface activity of the lungs of 9 patients dying of various causes, who were found to have atelectatic lobes or segments. The atelectatic portions of the lungs were found to... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pa. (BS) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAn osmiophilic bilaminar lining film at the respiratory surfaces of avian lungs 1 April 1963Volume 58, Issue 4Page: 739-740KeywordsLipoproteinsLungsPulmonary diseases Issue Published: 1 April 1963 PDF downloadLoading ...
Women with heart disease cautioned about HRT
Authors: D. Josefson
Journal: BMJ (1999)

Postmenopausal women with a history of coronary artery disease probably should not start taking hormone replacement therapy (HRT), according to a study presented at the annual meeting of the American College of Cardiology (7-10 March, New Orleans, Louisiana). The report is the second released within a year to question the use of HRT in postmenopausal women with heart disease.

Duke University researchers led by Dr Karen Alexander, performed an observational analysis of 1857 postmenopausal women with coronary artery disease. The study results were culled from a previous investigation, the coumadin-aspirin reinfarction study, which compared treatment with aspirin …
High Bone Density Due to a Mutation in LDL-Receptor–Related Protein 5
Authors: Lynn M. Boyden, Junhao Mao, Joseph Belsky, Lyle Mitzner, Anita Farhi, Mary A. Mitnick, Dianqing Wu, Karl Insogna, Richard P. Lifton
Journal: New England Journal of Medicine (2002)

Osteoporosis is a major public health problem of largely unknown cause. Loss-of-function mutations in the gene for low-density lipoprotein receptor–related protein 5 (LRP5), which acts in the Wnt signaling pathway, have been shown to cause osteoporosis–pseudoglioma.
258 ANTIFIBROTIC EFFECT OF CURCUMIN ON PROLONGED BILE DUCT OBSTRUCTION-INDUCED CIRRHOSIS IN RATS
Authors: K. Reyes-Gordillo, J. Segovia, M. Shibayama, V. Tsutsumi, P. Vergara, M.G. Moreno, P. Muriel
Journal: Journal of Hepatology (2008)
Effect of CCR2 and CCR5 Variants on HIV Disease Abstract and Commentary
Authors: Ronald G. Collman
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Liposomal Hsp90 cDNA induces neovascularization via nitric oxide in chronic ischemia
Authors: A PFOSSER, M THALGOTT, K BUTTNER, A BROUET, O FERON, P BOEKSTEGERS, C KUPATT
Journal: Cardiovascular Research (2004)

Induction of angiogenesis has been reported subsequent to eNOS overexpression or activation, the latter involving Hsp90 as a chaperone protein. Here, we investigated the potential of regional Hsp90 overexpression to induce therapeutic neovascularization in vivo in a chronic rabbit hindlimb ischemia model.
CARDIAC RETRANSPLANTATION: HOW FAR HAVE WE COME?
Authors: Eugene Christopher DePasquale, Richard Cheng, Ali Nsair, Leigh Reardon, Arnold Baas, Martin Cadeiras, Daniel Cruz, Nancy Halnon, Juan Alejos, Mario Deng, Hillel Laks, Abbas Ardehali
Journal: Journal of the American College of Cardiology (2014)