tbuckley/cabot-search huggingface dataset:
Hyperlipidemia Related to Miconazole Therapy
Authors: HAROLD D. ROSE
Journal: Annals of Internal Medicine (1979)

Letters1 September 1979Hyperlipidemia Related to Miconazole TherapyHAROLD D. ROSE, M.D., DONALD A. ROTH, M.D., PH.D., JOSEPH J. BARBORIAK, SC.D.HAROLD D. ROSE, M.D.Search for more papers by this author, DONALD A. ROTH, M.D., PH.D.Search for more papers by this author, JOSEPH J. BARBORIAK, SC.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-91-3-491_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Miconazole is an antifungal agent administered intravenously for the treatment of systemic infections. The drug is solubilized in aqueous solution by the use of polyethoxylated castor oil; this solubilizer has been reported to cause lipid abnormalities, including hyperlipedemia in humans and rats (1). The quantitative composition of the ethoxylated castor oil and the metabolic fate of several of its components are unknown.We have observed serum lipid changes in two patients undergoing treatment with maximum doses of 1.5 to 3 g of miconazole/d for 6 weeks. The volume infused in both patients was 150 to 300 mL/d,...References1. NAITO H and LEWIS L. Induced hyperlipidemia and delipidation of serum alpha-lipoproteins by polyethoxylated castor oil. In PEETERS H, ed. Protides of the Biological Fluids: Proceedings of the 25th Colloquium. New York: Pergamon Press, Inc. ; 1978: 393-8. Google Scholar2. ROSE H and VARKEY B. Miconazole treatment of relapsed pulmonary blastomycosis. Am Rev Respir Dis. 1978; 118:403-8. MedlineGoogle Scholar3. STEVENS D. Miconazole in the treatment of systemic fungal infections. Am Rev Respir Dis. 1977; 116:801-6. Editorial. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: HAROLD D. ROSE, M.D.; DONALD A. ROTH, M.D., PH.D.; JOSEPH J. BARBORIAK, SC.D.Affiliations: Medical College of Wisconsin Wood Veterans Administration Medical Center Milwaukee, WI 53193 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNew homogeneous HDL-cholesterol assay without the influence of high TG sample using the selective detergent to lipoproteinsMiconazole inhibition of platelet aggregation by inhibiting cyclooxygenaseOral Histoplasmosis Treated With Miconazole 1 September 1979Volume 91, Issue 3Page: 491-492KeywordsAntifungalsDrugsHyperlipidemiaLipidsOilsPatients ePublished: 1 December 2008 Issue Published: 1 September 1979 PDF downloadLoading ...
THROMBOMODULIN INHIBITS CARDIOMYOCYTE APOPTOSIS AND IMPROVES CARDIAC CONTRACTILE DYSFUNCTION IN RESPONSE TO CHRONIC PRESSURE OVERLOAD IN MICE
Authors: Yi-Heng Li, Hsing-Chun Chung, Chawn-Yau Luo, Ting-Hsing Chao, Ping-Yen Liu, Guey-Yueh Shi, Hua-Lin Wu
Journal: Journal of the American College of Cardiology (2010)
Long-Term Follow-Up After Cryothermic Ostial Pulmonary Vein Isolation in Paroxysmal Atrial Fibrillation
Authors: Wendel Moreira, Randy Manusama, Carl Timmermans, Benoit Ghaye, Suzanne Philippens, Hein J.J. Wellens, Luz-Maria Rodriguez
Journal: Journal of the American College of Cardiology (2008)
Delayed Graves' Ophthalmopathy
Authors: Todd D Nebesio, Erica A Eugster
Journal: New England Journal of Medicine (2010)

An 18-year-old man who had received a diagnosis of Graves’ disease at 13 years of age presented with several months of progressive eye changes. Physical examination revealed exotropia of the right eye, bilateral proptosis, periorbital edema, and conjunctival irritation.
SIROLIMUS–FKBP12.6 IMPAIRS ENDOTHELIAL BARRIER FUNCTION THROUGH PKCALPHA ACTUATION AND DISRUPTION OF THE VE CADHERIN–P120 CATENIN INTERACTION
Authors: Anwer Habib, Vinit Karmali, Rohini Polavarapu, Hirokuni Akahori, Kim Pachura, Fumiyuki Otsuka, Frank Kolodgie, Renu Virmani, Aloke Finn
Journal: Journal of the American College of Cardiology (2013)
Three-dimensional Mapping of the Common Atrial Flutter Circuit in the Right Atrium
Authors: Dipen C. Shah, Pierre Jaïs, Michel Haïssaguerre, Salah Chouairi, Atsusi Takahashi, Mélèze Hocini, Stéphane Garrigue, Jacques Clémenty
Journal: Circulation (1997)

Background The full circuit of common atrial flutter using conventional methods of sequential or multielectrode activation mapping is not completely understood. Methods and Results We performed three-dimensional right atrial endocardial activation mapping during common counterclockwise atrial flutter in 17 patients (16 men, 1 woman; mean age, 53±11 years) by using the Cordis-Biosense EP Navigation system and assessed the distribution of estimated conduction velocities and double and fractionated potentials. ECG flutter wave morphologies were compared with activation patterns. Points (91±29) were sequentially acquired covering 88±11% of the flutter cycle length of 239±22 ms. A wide and variable posterior zone of double and fractionated potentials coincided with blocking and colliding wave fronts and formed the posterior limit of the circuit. A progressively widening septal (sep) wave front ascending from just beyond the coronary sinus ostium, passed cranially as a broad front anterior to the superior vena cava (SVC) in 14 patients, whereas fusion around the SVC formed the superior (sup) limb of the circuit in 3. Bounded anteriorly by the tricuspid valve, the wave front descended down the lateral (lat) aspect of the right atrium before completing the circuit in all cases through the inferior vena cava–tricuspid annulus isthmus. The estimated conduction velocity in the medial isthmus (0.6±0.3 m/s) was lower than in the other limbs of the circuit (sup=1±0.5 m/s, lat=1±0.5 m/s, sep=0.9±0.4 m/s, P =.05). Double and fractionated potentials were constant and more prevalent in the posterior right atrium. ECG flutter wave morphology did not correlate with three-dimensional activation maps. Conclusions Interindividual variations occur in the right atrial circuit of common atrial flutter, with constant activation through the cavotricuspid isthmus. A variable zone of block forms the posterior limit. Fusion around the SVC can occur, and ascending medial septal activation does not follow a consistent pattern.
Bronchodilator treatment in moderate asthma or chronic bronchitis: continuous or on demand? A randomised controlled study.
Authors: C P van Schayck, E Dompeling, C L van Herwaarden, H Folgering, A L Verbeek, H J van der Hoogen, C van Weel
Journal: BMJ (1991)

OBJECTIVE--To examine the effect of bronchodilator treatment given continuously versus on demand on the progression of asthma and chronic bronchitis and to compare the long term effects of a beta 2 adrenergic drug (salbutamol) and an anticholinergic drug (ipratropium bromide). DESIGN--Two year randomised controlled prospective 9crossover9 study in which patients were assigned to one of two parallel treatment groups receiving continuous treatment or treatment on demand. SETTING--29 general practices in the catchment area of the University of Nijmegen. PATIENTS--223 patients aged greater than or equal to 30 with moderate airway obstruction due to asthma or chronic bronchitis, selected by their general practitioners. INTERVENTIONS--1600 micrograms salbutamol or 160 micrograms ipratropium bromide daily (113 patients) or salbutamol or ipratropium bromide only during exacerbations or periods of dyspnoea (110). No other pulmonary treatment was permitted. MAIN OUTCOME MEASURES--Decline in ventilatory function and change in bronchial responsiveness, respiratory symptoms, number of exacerbations, and quality of life. RESULTS--Among 144 patients completing the study, after correction for possible confounding factors the decline in forced expiratory volume in one second was -0.072 l/year in continuously treated patients and -0.020 l/year in those treated on demand (p less than 0.05), irrespective of the drug. The difference in the decline in patients with asthma was comparable with that in patients with chronic bronchitis (asthma: 0.092 v -0.025 l/year; chronic bronchitis: -0.082 v -0.031 l/year). Bronchial responsiveness increased slightly (0.4 doubling dose) with continuous treatment in chronic bronchitis, but exacerbations, symptoms, and quality of life were unchanged. Salbutamol and ipratropium bromide had comparable effects on all variables investigated. CONCLUSIONS--Continuous bronchodilator treatment without anti-inflammatory treatment accelerates decline in ventilatory function. Bronchodilators should be used only on demand, with additional corticosteroid treatment, if necessary.
Effects of Dextroamphetamine, Chlorpromazine, and Hydroxyzine on Behavior and Performance in Hyperactive Children
Authors: L. M. GREENBERG, M. A. DEEM, S. MCMAHON
Journal: American Journal of Psychiatry (1972)

In an eight-week double-blind study 61 hyperactive school-age boys were randomly assigned to chlorpromazine, dextroamphetamine, hydroxyzine, or placebo groups. Chlorpromazine and dextroamphetamine, virtually equally effective, were significantly more effective than hydroxyzine in modifying hyperactivity. Dextroamphetamine produced frequent side effects; chlorpromazine did not. The authors suggest that because response to the latter two drugs is highly individualized, final selection must depend upon clinical acumen and perhaps a trial of medication.
The Patient With Syncope
Authors: Robert C. Tarazi
Journal: JAMA (1977)

To the Editor.—   review of R. Joe Noble, MD, The Patient With Syncope (237:1372, 1977), is timely and quite helpful. However, two points require comment for different reasons.    first has its obvious bedside diagnostic implications; while lack of increase of heart rate with drop of blood pressure points to autonomic dysfunction, tachycardia on standing does not exclude a diagnosis of idiopathic orthostatic hypotension. 1 In contrast to usual teaching, heart rate in this disorder does vary in many patients with head-up tilt. 2 Cardiac nerves may not be involved until later in the evolution of the disease.   second concerns the value of plasma renin activity (PRA) in the localization of the neurologic defect.  distinction made in the diagram is based on one report 3 that has not been confirmed; in fact, our experience 4 and that of others is that PRA can increase with
Non-Variceal Upper Gastrointestinal Bleeding and Forrest's Classification: Diagnostic Agreement Between Endoscopists from the Same Area
Authors: A. Mondardini, C. Barletti, G. Rocca, A. Garripoli, A. Sambataro, C. Perotto, A. Repici, A. Ferrari
Journal: Endoscopy (1998)

The lack of uniformity in defining the stigmata of hemorrhage in patients with bleeding ulcers is suggested by the wide range among published studies in prevalence and rebleeding rates for the same stigmata. Moreover there is, in published trials of endoscopic hemostasis, little standardization of definitions of stigmata of hemorrhage. The aim of this study was to assess the interobserver agreement among endoscopists from the same area (Piedmont and Valley of Aosta).A workshop for 47 expert endoscopists was organized in order to evaluate their agreement in the diagnosis of stigmata of recent hemorrhage, according to Forrest's classification. During the meeting 25 videotapes from endoscopic examinations of patients with recent non-variceal bleeding were shown to the 47 endoscopists, who were asked to classify every lesion.The overall and beyond chance interobserver agreement was calculated by means of the kappa statistic. The overall agreement among endoscopists was highly significant (p < 0.001, kappa=0.60), while the beyond chance agreement varied from excellent to good for lesions with active bleeding (kappa=0.76 and kappa=0.61 for FIA and FIB lesions respectively), whereas for lesions with stigmata of recent hemorrhage kappa varied from 0.44 to 0.49.These data suggest the need for better knowledge of endoscopic criteria, in order to evaluate the results of endoscopic therapy and to assess new treatments.
Medical abortion becomes available in Italy
Authors: M. Day
Journal: BMJ (2010)

Medical abortion became available across Italy last week after a 15 year battle between women’s groups and the Catholic church, which has split the country’s medical profession down the middle.

But while the major regions of Tuscany, Emilia Romagna, and Lombardy finally made the procedure available, others seemed to be dragging their heels.

And within hours of the first mifepristone pill (also known as RU486) being given on Thursday there was fresh controversy when the 29 year old recipient discharged herself from the clinic in the southern city of Bari, in contravention of guidelines stating that the patient must stay in hospital for the duration of medical abortion.

The health ministry …
Drug firms and regulatory agencies must consider how drugs are used
Authors: L. Hitchen
Journal: BMJ (2008)

Safety experts have criticised drug regulators and the drug industry for not doing enough to ensure that packaging and labelling of products is safe.

Both concentrate on the efficacy and safety of the drug or device, but do not look at how it is used in practice, Liz Kay, clinical director of pharmacy for Leeds Teaching Hospitals NHS Trust, told the BMJ at a seminar on delivering safer intravenous drugs in Birmingham last week.

“The practical use of medicines is not high enough priority. Not enough emphasis is given to how the drug is used in a healthcare setting and how it is used by the patient,” she said.

The seminar focused on the National Patient Safety Agency’s patient safety alert on injectable drugs, issued …
Overexpression of Interleukin 13 (IL-13) in the Skin Induces Dermatitis and Pulmonary Inflammation and Airway Hyperresponsiveness to Allergen Challenge
Authors: T. Zheng, S. Oh, M. Oh, M. Wang, A. Myers, J. Schroeder, Z. Zhu
Journal: Journal of Allergy and Clinical Immunology (2007)
I would scrap the internal market
Authors: S. Ford
Journal: BMJ (2015)

Patients are, or should be, the sole reason for the existence of healthcare, and every patient matters equally. Ameliorating the fear of illness, injury, suffering, and death, by considering the full spectrum of physical, psychological, and social dimensions, is, or should be, the sole focus.

Every citizen has a duty to use the NHS responsibly and to take personal responsibility for their own health.

Healthcare, correctly delivered, is not and never can be a commercial undertaking. All diversion of resources (profits, dividends, bonuses, transaction costs, and so forth) represents treatment denied and is, self evidently, directly harmful to patients and injurious to the public realm and the common good. Patients must receive …
Gastrointestinal Disease: An Endoscopic Approach
Authors: Frank L. Iber
Journal: JAMA (1997)

Diagnostic and therapeutic endoscopy is an essential and growing part of gastroenterology, and it is appropriate that many leaders in endoscopy are included as authors of an entire text emphasizing it.<i>Gastrointestinal Disease: An Endoscopic Approach</i>consists of seven major parts of from 5 to 27 chapters, each supervised by a section editor. These cover major regions of the gastrointestinal tract, with sections on introduction to endoscopy and newer endoscopic horizons. The chapter authors are actively working and publishing, and most are under 45 years of age, reflecting relatively recent training in these highly technological skills. The volumes contain great numbers of clear color endoscopic illustrations, cropped to show lesions, and many reproductions of endoscopic sonograms, images, and occasionally micrographs and clinical photographs. The illustrations appear in the text where they are discussed, and quality and size are outstanding. Bold type is used in tables to present literature reviews and
Evaluation of Acute Knee Pain in Primary Care
Authors: Jeffrey L. Jackson, Patrick G. O'Malley, Kurt Kroenke
Journal: Annals of Internal Medicine (2003)

Background: The evaluation of acute knee pain often includes radiography of the knee. Objective: To synthesize the literature to determine the role of radiologic procedures in evaluating common causes of acute knee pain: fractures, meniscal or ligamentous injuries, osteoarthritis, and pseudogout. Data Sources: MEDLINE search from 1966 to October 2002. Study Selection: We included all published, peer-reviewed studies of decision rules for fractures. We included studies that used arthroscopy as the gold standard for measuring the accuracy of the physical examination and magnetic resonance imaging (MRI) for meniscal and ligamentous knee damage. We included all studies on the use of radiographs in pseudogout. Data Extraction: We extracted all data in duplicate and abstracted physical examination and MRI results into 2 2 tables. Data Synthesis: Among the 5 decision rules for deciding when to use plain films in knee fractures, the Ottawa knee rules (injury due to trauma and age >55 years, tenderness at the head of the fibula or the patella, inability to bear weight for 4 steps, or inability to flex the knee to 90 degrees) have the strongest supporting evidence. When the history suggests a potential meniscal or ligamentous injury, the physical examination is moderately sensitive (meniscus, 87%; anterior cruciate ligament, 74%; and posterior cruciate ligament, 81%) and specific (meniscus, 92%; anterior cruciate ligamen, 95%; and posterior cruciate ligament, 95%). The Lachman test is more sensitive and specific for ligamentous tears than is the drawer sign. For meniscal tears, joint line tenderness is sensitive (75%) but not specific (27%), while the McMurray test is specific (97%) but not sensitive (52%). Compared with the physical examination, MRI is more sensitive for ligamentous and meniscal damage but less specific. When the differential diagnosis for acute knee pain includes an exacerbation of osteoarthritis, clinical features (age >50 years, morning stiffness <30 minutes, crepitus, or bony enlargement) are 89% sensitive and 88% specific for underlying chronic arthritis. Adding plain films improves sensitivity slightly but not specificity. Plain films for pseudogout are not sensitive or specific, according to limited-quality studies. Conclusions: We recommend the Ottawa knee rules to decide when to obtain plain films for suspected knee fracture. A careful physical examination should be sufficient to decide whether to refer patients with potential meniscal and ligament injuries, and we prefer clinical criteria rather than plain films for evaluating osteoarthritis. We do not recommend using plain films to diagnose pseudogout.
Scalar Amplitude Measurements of Data Recorded with Cube and Frank Leads from Normal Children
Authors: E. RAYMOND BORUN, SAMUEL O. SAPIN, STANLEY J. GOLDBERG
Journal: Circulation (1969)

Amplitudes of scalar deflections were measured in records obtained with cube and Frank lead systems from 542 healthy children. Significant correlations were observed between corresponding deflections recorded with the two lead systems. There were significant correlations between amplitudes of some scalar deflections and age, chest diameter, height, and weight, but the scatter of individual values was too large to allow accurate prediction of measurements from regression equations. Means for scalar amplitude measurements showed several patterns of change from infancy through adult years. Normal limits for these measurements should, therefore, be stratified by age in children as well as in adults. Normal limits for scalar amplitudes and ratios between amplitude measurements were presented for four age groups of children. Correlation between age and body measurements was so high in these children that further stratification of normal limits on the basis of body measurements is not likely to provide additional useful information. There were differences in scalar measurements between males and females 10 to 16 years of age, but these were small.
Metabolic network as a progression biomarker of premanifest Huntington’s disease
Authors: Chris C. Tang, Andrew Feigin, Yilong Ma, Christian Habeck, Jane S. Paulsen, Klaus L. Leenders, Laura K. Teune, Joost C.H. van Oostrom, Mark Guttman, Vijay Dhawan, David Eidelberg
Journal: Journal of Clinical Investigation (2013)

The evaluation of effective disease-modifying therapies for neurodegenerative disorders relies on objective and accurate measures of progression in at-risk individuals. Here we used a computational approach to identify a functional brain network associated with the progression of preclinical Huntington's disease (HD).Twelve premanifest HD mutation carriers were scanned with [18F]-fluorodeoxyglucose PET to measure cerebral metabolic activity at baseline and again at 1.5, 4, and 7 years. At each time point, the subjects were also scanned with [11C]-raclopride PET and structural MRI to measure concurrent declines in caudate/putamen D2 neuroreceptor binding and tissue volume. The rate of metabolic network progression in this cohort was compared with the corresponding estimate obtained in a separate group of 21 premanifest HD carriers who were scanned twice over a 2-year period.In the original premanifest cohort, network analysis disclosed a significant spatial covariance pattern characterized by progressive changes in striato-thalamic and cortical metabolic activity. In these subjects, network activity increased linearly over 7 years and was not influenced by intercurrent phenoconversion. The rate of network progression was nearly identical when measured in the validation sample. Network activity progressed at approximately twice the rate of single region measurements from the same subjects.Metabolic network measurements provide a sensitive means of quantitatively evaluating disease progression in premanifest individuals. This approach may be incorporated into clinical trials to assess disease-modifying agents.Registration is not required for observational studies.NIH (National Institute of Neurological Disorders and Stroke, National Institute of Biomedical Imaging and Bioengineering) and CHDI Foundation Inc.
Diabetes and the Course of Febrile Urinary Tract Infection
Authors: Willize E. van der Starre, Hanneke Borgdorff, Albert M. Vollaard, Nathalie M. Delfos, Jan W. van ’t Wout, Ida C. Spelt, Jeanet W. Blom, Eliane M.S. Leyten, Ted Koster, Hans C. Ablij, Jaap T. van Dissel, Cees van Nieuwkoop
Journal: Diabetes Care (2013)

Diabetes is considered a risk factor for acquisition of febrile urinary tract infection (UTI) (1,2), but there is a lack of information on the association of diabetes with the subsequent course of disease and its outcome. We performed a prospective observational multicenter cohort study including consecutive adults with community-onset febrile UTI presenting at 7 emergency departments and 35 primary care centers. The effect of preexisting diabetes on presentation and microbiological and clinical outcome was assessed and multivariable logistic regression performed to establish whether diabetes was an independent risk factor for a complicated course.

View this table:

Table 1 
Baseline characteristics of 858 patients presenting with febrile UTI



Of 858 patients, 140 had diabetes (93% type 2 diabetes), of whom 41 (30%) used insulin, 19 (14%) were managed by diet only, and the remaining were managed by a combination of metformin, insulin, and diet. Patients with diabetes were older (median age 73 years [interquartile range {IQR} 46–78] vs. 64 [IQR 42–77], P < 0.001), were more frequently male (48 vs. 35%, P = 0.006), and had a higher …