Immunosuppressive Therapy in Lupus Erythematosus
Authors: NAOMI F. ROTHFIELD
Journal: Annals of Internal Medicine (1975)

Editorials1 November 1975Immunosuppressive Therapy in Lupus ErythematosusNAOMI F. ROTHFIELD, M.D.NAOMI F. ROTHFIELD, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-83-5-727 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe use of immunosuppressive therapy in patients with systemic lupus erythematosus has become widespread during the past few years because of a number of reports describing its efficacy. These reports suggest that the use of cytotoxic drugs with corticosteroids leads to a more favorable outcome than treatment with corticosteroids alone. The enthusiastic use of several of these agents is now common and is not always reserved for those patients with life-threatening disease. Most of the literature upon which such enthusiasm is based consists of case reports or uncontrolled trials. Other studies have compared a group of patients recently treated with...References1. SZTEJNBOKSTEWARTDIAMOND MAH: Azathioprine in the treatment of systemic lupus erythematosus: a controlled study. Arthritis Rheum 14:639-645, 1971 CrossrefMedlineGoogle Scholar2. CADESPOONERSCHLEIN RGG: Comparison of azathioprine, prednisone, and heparin alone or combined in treating lupus nephritis. Nephron 10:37-56, 1973 CrossrefMedlineGoogle Scholar3. DONADIOHOLLEYWAGONER JRR: Further observations on the treatment of lupus nephritis with prednisone and combined prednisone and azathioprine. Arthritis Rheum 17:573-581, 1974 CrossrefMedlineGoogle Scholar4. HAHNKANTOROSTERLAND BOC: Azathioprine plus prednisone compared with prednisone alone in the treatment of systemic lupus erythematosus. Report of a prospective controlled trial in 24 patients. Ann Intern Med 53:597-605, 1975 LinkGoogle Scholar5. DECKERKLIPPELPLOTZ JJ: Cyclophosphamide or azathioprine in lupus glomerulonephritis. A controlled trial: results at 28 months. Ann Intern Med 83:606-615, 1975 LinkGoogle Scholar6. GELFANDSTEINBERG MA: Therapeutic studies in NZB/W mice. II. Relative efficacy of azathioprine, cyclophosphamide and methylprednisolone. Arthritis Rheum 15:247-251, 1972 CrossrefMedlineGoogle Scholar7. HAHNKNOTTSNG BLM: Influence of cyclophosphamide and other immunosuppressive drugs on immune disorders and neoplasia in NZB/NZW mice. Arthritis Rheum 18:145-152, 1975 CrossrefMedlineGoogle Scholar8. CASEY T: Immunosuppression by cyclophosphamide in NZB X NZW mice with lupus nephritis. Blood 32:436-444, 1968 CrossrefMedlineGoogle Scholar9. LIPSMEYER E Development of malignant cerebral lymphoma in a patient with systemic lupus erythematosus treated with immunosuppression. Arthritis Rheum 15:183-186, 1972 CrossrefMedlineGoogle Scholar10. UHLWILLIAMSARNETT GJF: Intracerebral lymphoma in a patient with central nervous system lupus on cyclophosphamide. J Rheum 1:282-286, 1974 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Division of Rheumatic Diseases Department of Medicine School of Medicine University of Connecticut Farmington, Connecticut PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByNonsteroidal Immunosuppressive Therapy in Polymyositis and DermatomyositisSystemic Lupus Erythematosus in Childhood: A 10-Year ExperienceClinical pharmacology and toxicology of cyclophosphamide: emphasis on use in rheumatic diseasesImmunosuppressive Therapy in Rheumatic DiseaseLupus Erythematosus: Immunosuppressive TherapyE. V. BARNETT, M.D.Immunosuppressive Drugs in Lupus NephritisWALLACE V. EPSTEIN, M.D., F.A.C.P., MARTIN A. SHEARN, M.D., F.A.C.P.Lupus NephritisTreatment of Lupus ErythematosusDAVID KAPLAN, M.D., HERBERT S. DIAMOND, M.D., ELLEN M. GINZLER, M.D. 1 November 1975Volume 83, Issue 5Page: 727-728KeywordsDrugsImmunosuppressivesLupus erythematosus Issue Published: 1 November 1975 PDF DownloadLoading ...