tbuckley/cabot-search huggingface dataset:
The Physician, the Media, and the 'Spectacular' Case
Authors: William C. DeVries
Journal: JAMA (1988)

Drawing on his experiences as a pioneer in performing artificial heart transplants for illustration, DeVries considers the dilemmas that the physician-researcher working on a "spectacular" medical case confronts in dealing with the news media. He discusses five major concerns: the patient's privacy; the effects of the media on the treatment of the patient; the integrity of the experiment; hospital disruptions; and the negative reactions of peers who perceive physician-researchers as self-aggrandizing. DeVries concludes that physician cooperation with the press is necessary and desirable, but that it should be based on the following principles: (1) concern for the patient and family is paramount, taking precedence over the public's right to know; (2) any information released must be accurate; and (3) advance preparation regarding the logistics of reporting the news quickly and accurately is essential.
MANOMETER AND SAFETY-VALVE FOR USE IN THE OPERATION OF ARTIFICIAL PNEUMOTHORAX
Authors: Lewis Sayre Mace
Journal: JAMA (1913)

I wish to describe a simple and easily made manometer and safety-valve which I have found useful as an addition to the usual Forlanini apparatus which is used in the operation of artificial pneumothorax in lung tuberculosis. This consists of a liter Erlenmyer flask having a three-holed stopper. Two glass tubes are arranged as in an ordinary wash-bottle, and through these tubes the gas is passed through warm sterile saline solution before its introduction into the pleural cavity. The third is a perpendicular tube open at both ends, by means of which the operator is enabled to read the intrapleural pressure at any moment while the gas is being introduced. This manometer tube has an opening at a certain height above the level of the saline solution in the flask, so that if at any moment during the operation the positive pressure should rise to a dangerous height the liquid
Laparoscopic management of colorectal cancer
Authors: F. L. Greene
Journal: CA A Cancer Journal for Clinicians (1999)

Laparoscopic treatment of colorectal cancer has emerged as a result of the technical advances that have been made since the introduction of laparoscopic cholecystectomy. The minimal-access approach to treatment of benign disease results in smaller incisions, reduced length of hospital stay, and a faster return to productive life. Laparoscopic approaches to colon cancer must take into consideration the potential effects of the technique on tumor dissemination at the time of the surgical procedure, as well as rates of recurrence and overall survival. Several technical approaches to laparascopic colon resection have now become possible, utilizing either total intra-abdominal maneuvers or laparoscopic-assisted techniques. Margins of resection and lymph node removal with the minimal-access techniques compare favorably with those of open colectomy. Several series now show that early results utilizing laparoscopic resection for colorectal cancer are favorable but that routine implementation of this procedure should await confirmatory outcomes generated by well-done prospective clinical trials. (CA Cancer J Clin 1999;49:221–228.)
Menetrier??s Disease with Occlusion of Splenic and Brachial Arteries
Authors: JAMES P. POLGA, RICHARD P. SPENCER
Journal: Clinical Nuclear Medicine (1982)

A 40-year-old man presented with occlusion of the left brachial artery and sudden onset of abdominal pain. A radiocolloid scan revealed a fragmented appearance to the spleen. This was found to be due to multiple splenic infarcts. Results of an upper gastrointestinal series and tissue biopsy specimen established the diagnosis of Menetrier's disease. It was noted that at least one report in the literature suggested that vascular occlusions may be part of the natural history of Menetrier's disease.
Hematoma of the Interatrial Septum with Heart Block Secondary to Dissecting Aneurysm of the Aorta
Authors: MAGDI H. YACOUB, MARK SCHOTTENFELD, C. FREDERICK KITTLE
Journal: Circulation (1972)

Four patients with a hematoma of the interatrial septum secondary to acute dissecting aneurysm of the aorta are described. Hematoma of the interatrial septum presents with clinical features of acute dissecting aneurysm of the aorta and partial or complete heart block. Anatomically, the hematoma traverses the aortoatrial space to involve the A-V node and the bundle of His. Early operation is indicated.
IV salbutamol increased mortality in patients with the acute respiratory distress syndrome
Authors: Clarence Chant, Karen E.A. Burns
Journal: Annals of Internal Medicine (2012)

Source Citation Gao Smith F, Perkins GD, Gates S, et al; BALTI-2 study investigators. Effect of intravenous β-2 agonist treatment on clinical outcomes in acute respiratory distress syndrome (BALTI-2): a multicentre, randomised controlled trial. Lancet. 2012;379:229-35. 22166903
Sunset at Camp O'Donnell
Authors: David Brown
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The British Pharmacopeia.
Authors: N. O'D. Parks
Journal: JAMA (1901)

Ashton, R. I., Jan. 21, 1901. <h3>To the Editor:</h3> —InThe Journalof January 19, your London correspondent speaking of the British Pharmacopeia states that there were converted into this three pharmacopeias in the United Kingdom, issued by the Colleges of Physicians of London, Edinburgh and Glasgow respectively. Now. in a great organ of professional thought and action likeThe Journalits readers expect above all things accuracy. There are, undoubtedly, in the United Kingdom three colleges of physicians, one for each kingdom, in London, Edinburgh and Dublin. Your correspondent robs Ireland, giving Scotland double her due.
Picturing Health and Illness: Images of Identity and Difference
Authors: William H. Tucker
Journal: JAMA (1995)

"It is amazing how complete is the delusion that beauty is goodness," wrote Tolstoy in the late 19th century. Soon thereafter, social scientists in the United States provided fresh evidence for the accuracy of Tolstoy's observation when they made frequent diagnoses of intellectual defectiveness solely on the basis of an unattractive appearance. In his famous 1914 study of the Kallikak family, psychologist Henry H. Goddard confidently described children "with drooping jaws and the unmistakable look of the feebleminded,"<sup>1</sup>and in the same year sociologist Edward Alsworth Ross looked at all the "hirsute, lowbrowed, big faced" immigrants with their "sugarloaf heads, moon-faces, slit mouths, lantern jaws, and goose bill noses" and concluded that "the physiognomy of certain groups unmistakably proclaims inferiority of type."<sup>2</sup> Of course, these absurdly subjective claims emanated from the "soft" sciences, those marked by a seemingly endless and subjective debate over the nature and distribution of
Further In Vivo Evidence That Cellular Senescence Is Implicated in Vascular Pathophysiology
Authors: Jorge D. Erusalimsky, Mark Fenton
Journal: Circulation (2002)

To the Editor:We have read with interest the study of Minamino et al 1 demonstrating endothelial cell senescence in human atherosclerotic lesions.In their study, senescence was detected using the marker known as senescence-associated ␤-galactosidase (SA-␤gal), 2,3 and endothelial cells were identified by immunohistochemistry.This demonstration of the occurrence of senescent endothelial cells in vivo confirms and extends the results from the studies of Vasile et al 4 and of Fenton et al, 5 both of which were published in February 2001.As far as we are aware, these papers were the first to describe the occurrence of vascular cell senescence in vivo using the SA-␤-gal marker.Vasile et al 4 have demonstrated the occurrence of endothelial cells overlying human aortic atherosclerotic plaques that expressed SA-␤-gal activity and that showed differential gene expression consistent with a senescent phenotype.Fenton et al 5 used a balloon endothelial denudation model as a mechanism for promoting vascular cell replication to look for vascular cell senescence in non-atheromatous rabbit carotid arteries.Six weeks after a single denudation, SA-␤-gal-positive cells were found in both the neointima and the media, and immunohistochemical analysis identified these as endothelial and vascular smooth muscle cells.A second denudation resulted in a marked acceleration in the accumulation of senescent cells in the arterial wall.The senescent cells did not show evidence of apoptosis as assessed by terminal deoxynucleotidyltransferasemediated dUTP nick end labelling analysis.The evidence that endothelial cell senescence can occur in vivo seems to be growing, and it is encouraging to see another paper that supports this contention.
Response to Letter Regarding Article, “Biglycan Is Required for Adaptive Remodeling After Myocardial Infarction”
Authors: D. Westermann, O. Lettau, H.P. Schultheiss, C. Tschöpe, J. Mersmann, A. Melchior, T. Freudenberger, J.W. Fischer, C. Petrik, T. Unger, L. Schaefer, R. Lüllmann-Rauch, C. Jacoby, J. Schrader, S.M. Brand-Herrman, M.F. Young, B. Levkau, H.A. Baba, K. Zacharowski
Journal: Circulation (2008)
Handbook of Psychiatry
Authors: Samuel Friedman
Journal: JAMA (1970)

Assisted by a large staff of relatively young contributors, Solomon and Patch have put together a text aimed at the general practitioner, first-year psychiatric resident and ancillary personnel. To paraphrase, rarely have so many covered so much ground in so relatively little space. Although the book follows fairly classical lines of presentation, it extends somewhat beyond the usual boundaries, viz, the chapter on statistics in psychiatry. An initial section on history, examination, theory, etc, precedes the sections devoted to clinical syndromes and treatment. The somewhat novel chapter on common psychiatric signs and symptoms and the suggested differential diagnoses appears particularly worthwhile. I would, however, take some exception to the statement that anxiety neurosis is "largely a diagnosis of exclusion." The discussion of adolescent and college psychiatry is also most pertinent in view of the burgeoning problems in this area. Thirteen chapters on therapy cover kaleidoscopically all phases of treatment. The
Dislocation of the Humerus Reduced under the Influence of Chloroform, with Observations
Authors: W. Newnham
Journal: BMJ (1848)

EFF" TS OF OVERLOADED, BOWELS.pa4 o4e thbetjgbs6 mmatimep also at the bend of the art ;it .ga;lyAffqcts the lower more Ohan the 'W; pW4 of.the body; tbere may, however, be oot"sJlj e.oM, *long with ,the 4ffection of the lower ppt, .nryhemstous patch on each cheek.I14i ist, cs the rash extends over the whole body, producing frequently a &hmefaction of the skin,
Agonist-antagonist interactions at angiotensin receptors: application of a two-state receptor model
Authors: Mark J. Robertson, Iain G. Dougall, Diane Harper, Kenneth C.W. McKechnie, Paul Leff, M.J. Roberatson, I.G. Dougall, D. Harper, K.C.W. Mckechnie, P. Leff
Journal: Trends in Pharmacological Sciences (1994)
USE OF MONOPHASIC ACTION POTENTIAL RECORDINGS DURING ROUTINE CORONARY-ARTERY BYPASS SURGERY AS AN INDEX OF LOCALISED MYOCARDIAL ISCHAEMIA
Authors: Peter Taggart, Michael Runnalls, Robert Donaldson, Howard Swanton, Peter Sutton, William O'Brien, Roger Hayward, Richard Emanuel, Tom Treasure
Journal: The Lancet (1986)
Adding NT-proBNP–guided management to multidisciplinary care reduced heart failure rehospitalization days
Authors: Bertram Pitt
Journal: Annals of Internal Medicine (2010)

Source Citation Berger R, Moertl D, Peter S, et al. N-terminal pro-B-type natriuretic peptide-guided, intensive patient management in addition to multidisciplinary care in chronic heart failure. A 3-arm, prospective, randomized pilot study. J Am Coll Cardiol. 2010;55:645-53. 20170790
Association between Malignant Disease in Children and Maternal Virus Infections
Authors: J. F. Bithell, G. J. Draper, P. D. Gorbach
Journal: BMJ (1973)

The possibility of an association between virus infections during pregnancy and subsequent malignant disease in the child has been investigated using retrospective data from the Oxford Survey of Childhood Cancers. Such an association appears to exist for influenza, chickenpox, and possibly rubella. For influenza and rubella the estimated risk is small; the data do not permit an estimate to be made directly in the case of chickenpox. It is suggested that there may be a specific association between maternal chickenpox and tumours of the nervous system.It is important to emphasize that, even if the relative risk associated with these viruses is fairly large, the number of cases of childhood cancer and leukaemia actually attributable to them is probably very small.
Effects of BCG revaccination on asthma
Authors: I. S. Choi, Y. I. Koh
Journal: Allergy (2003)

In a study conducted 1 year ago, we found that Th1 immune enhancement following Bacille Calmette–Guérin (BCG) vaccination effectively suppressed human asthma. To investigate whether revaccination would further improve lung function, BCG vaccine was given again. Current lung function tended to improve in the Repeated BCG group ( n = 9), but not in the Single BCG group (previously the placebo group) ( n = 11), compared with that 1 year ago. The BCG vaccination improved lung function in both groups, and the Repeated BCG group showed a significant increase in the peripheral blood interferon γ /interleukin 4 ratio. These findings suggest that repeated BCG vaccinations might be effective in asthma therapy.
CLINICAL COUNTERPOINT: Gonadotropin-Releasing Hormone Deficiency: Perspectives from Clinical Investigation*
Authors: WILLIAM F. CROWLEY, J. LARRY JAMESON
Journal: Endocrine Reviews (1992)

Advances in our understanding of the pathophysiology of Kallmann syndrome have come from an interdisciplinary approach involving developmental biology, clinical investigation, and molecular biology. It is equally clear that progress to date is but the first chapter of what will be a fascinating biological story. It now seems likely that the full expression of reproductive potential from the neuroendocrine perspective is likely to be as complicated as other aspects of reproduction, such as the multigene control of external genital differentiation. An analogous story may well emerge for the neuroendocrine control of reproduction in which the GnRH gene is encoded on the eighth chromosome, the protein guiding the embryonic journey of the GnRH-producing neuron to the hypothalamus lies on the X chromosome, and many, as yet to be determined, other genetic loci collaborate in the full expression of reproductive potential. Such a detailed study is warranted not only because of the clinical and genetic implications for an individual patient with this disorder, but also from an organizational theme for the evolution of the species (and its potential regulation). Given the pressing nature of world population growth, obtaining such understanding and its applications to fertility and contraception is crucial. These advances will only come from enlightened interactions of clinical investigators, molecular geneticists, and developmental biologists in which interdisciplinary approaches should be fostered. This should be an exciting story to follow given the remarkable nature of the tools at hand to study these clinical conditions.
Mitochondrial Biogenesis Restores Oxidative Metabolism during <i>Staphylococcus aureus</i> Sepsis
Authors: Douglas W. Haden, Hagir B. Suliman, Martha Sue Carraway, Karen E. Welty-Wolf, Abdelwahid S. Ali, Hiroshi Shitara, Hiromichi Yonekawa, Claude A. Piantadosi
Journal: American Journal of Respiratory and Critical Care Medicine (2007)

Rationale: The extent, timing, and significance of mitochondrial injury and recovery in bacterial sepsis are poorly characterized, although oxidative and nitrosative mitochondrial damage have been implicated in the development of organ failure.Objectives: To define the relationships between mitochondrial biogenesis, oxidative metabolism, and recovery from Staphylococcus aureus sepsis.Methods: We developed a murine model of fibrin clot peritonitis, using S. aureus. The model yielded dose-dependent decreases in survival and resting energy expenditure, allowing us to study recovery from sublethal sepsis.Measurements and Main Results: Peritonitis caused by 106 colony-forming units of S. aureus induced a low tumor necrosis factor-α state and minimal hepatic cell death, but activated prosurvival protein kinase A, B, and C sequentially over 3 days. Basal metabolism by indirect calorimetry was depressed because of selective mitochondrial oxidative stress and subsequent loss of mitochondrial DNA copy number. During recovery, mitochondrial biogenesis was strongly activated by regulated expression of the requisite nuclear respiratory factors 1 and 2 and the coactivator peroxisome proliferator-activated receptor γ coactivator-1α, as well as by repression of the biogenesis suppressor nuclear receptor interacting protein-140. Biogenesis reconstituted mitochondrial DNA copy number and transcription, and restored basal metabolism without significant hepatocellular proliferation. These events dramatically increased hepatic mitochondrial density in transgenic mice expressing mitochondrially targeted green fluorescent protein.Conclusions: This is the first demonstration that mitochondrial biogenesis restores oxidative metabolism in bacterial sepsis and is therefore an early and important prosurvival factor.
Carotid angioplasty: initial experience with the flow reversal technique for prevention of embolic complications
Authors: Horst Sievert, Kasja Rabe, Wolfgang Pfeil, Christine Rubel, Andreas Fach, Detlev Scherer, Hans Spies, Hildegard Lißmann-Jensen, Britta Schulte, Rudi Theis, KaiFriedrich Beykirch
Journal: Journal of the American College of Cardiology (2002)
Abstract 5576: Rhamnetin inhibits human prostate cancer cell growth through cell-cycle arrest by modulating expression and function of key cell-cycle regulators and survival molecules
Authors: Sanjeev Shukla, Natarajan Bhaskaran, Sanjay Gupta
Journal: Cancer Research (2011)

Abstract Development of effective agents for treatment of prostate cancer has become a national medical priority. Rhamnetin (3,5,3,4-tetrahydroxy-7-methoxyflavone), a natural compound known as O-methylated flavonol, abundantly present in cloves, sweet annie, annual wormwood, green vegetables and orchard grass has shown to possess anti-inflammatory and antioxidant properties. However, the anticancer properties of rhamnetin have not been fully elucidated. In the present study we demonstrated the molecular mechanism of cell growth inhibition and induction of apoptosis in human prostate carcinoma LNCaP and PC-3 cells by rhamnetin. Treatment of these cells with rhamnetin resulted in a dose (5, 10, 20, 40 microM) and time (24, 48 and 72 h) dependent inhibition of growth, G2-S phase arrest of the cell cycle and DNA fragmentation. This effect was associated with a marked decrease in the protein expression of cyclin D1, D2, and E and their activating partner, cyclin-dependent kinase (cdk) 2, 4, and 6, with concomitant upregulation of WAF1/p21, KIP1/p27, INK4a/p16, and INK4c/p18. Rhamnetin treatment also resulted in alteration in Bax/Bcl2 ratio in favor of apoptosis, which was associated with the release of cytochrome-c and induction of apoptotic protease-activating factor-1 (Apaf-1). This effect was found to result in a significant increase in cleaved fragments of caspase-9, -3, and poly (ADP-ribose) polymerase (PARP). Further, rhamnetin treatment resulted in down modulation of XIAP, survivin, and c-Myc protein expressions. Taken together, we concluded that molecular mechanisms during rhamnetin-mediated growth inhibition and induction of apoptosis in both androgen-responsive, LNCaP and androgen-refractory, PC-3 cells was due to modulation in cell-cycle machinery, disruption of mitochondrial function, and inhibition of cell survival machinery. For the first time we provide evidence that rhamnetin acts on potential molecular targets of cell cycle regulation and survival to elicit anticancer effects in prostate cancer cells. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 5576. doi:10.1158/1538-7445.AM2011-5576
Platelet function is altered by autogenous vein grafts in the early postoperative months
Authors: A. H GERSHLICK, Y D. S. COURT, A. J MURDAY, T. LEWIS, P. G MILLS
Journal: Cardiovascular Research (1984)

Journal Article Platelet function is altered by autogenous vein grafts in the early postoperative months Get access ANTHONY H GERSHLICK, ANTHONY H GERSHLICK * From the Departments of Cardiology and Cardiothoracic Surgery, the London Hospital, Whitechapel, London, El *Address for reprint requests: A H Gershlick, MRCP, Department of Cardiology, The London Hospital, Whitechapel, London, El. Search for other works by this author on: Oxford Academic PubMed Google Scholar Y DENISE SYNDERCOMBE COURT, Y DENISE SYNDERCOMBE COURT From the Departments of Cardiology and Cardiothoracic Surgery, the London Hospital, Whitechapel, London, El Search for other works by this author on: Oxford Academic PubMed Google Scholar ANDREW J MURDAY, ANDREW J MURDAY From the Departments of Cardiology and Cardiothoracic Surgery, the London Hospital, Whitechapel, London, El Search for other works by this author on: Oxford Academic PubMed Google Scholar TERENCE LEWIS, TERENCE LEWIS From the Departments of Cardiology and Cardiothoracic Surgery, the London Hospital, Whitechapel, London, El Search for other works by this author on: Oxford Academic PubMed Google Scholar PETER G MILLS PETER G MILLS From the Departments of Cardiology and Cardiothoracic Surgery, the London Hospital, Whitechapel, London, El Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 18, Issue 2, February 1984, Pages 119–125, https://doi.org/10.1093/cvr/18.2.119 Published: 01 February 1984