tbuckley/cabot-search huggingface dataset:
Ventricular Arrhythmia Vulnerability in Cardiomyopathic Mice With Homozygous Mutant Myosin-Binding Protein C Gene
Authors: Charles I. Berul, Bradley K. McConnell, Hiroko Wakimoto, Ivan P.G. Moskowitz, Colin T. Maguire, Christopher Semsarian, Marcel M. Vargas, Josef Gehrmann, Christine E. Seidman, Jonathan G. Seidman
Journal: Circulation (2001)

Background Homozygous mutant mice expressing a truncated form of myosin-binding protein C (MyBP-C t/t ) develop severe dilated cardiomyopathy, whereas the heterozygous mutation (MyBP-C t/+ ) causes mild hypertrophic cardiomyopathy. Adult male MyBP-C t/t and MyBP-C t/+ mice were evaluated for arrhythmia vulnerability with an in vivo electrophysiology study. Methods and Results Surface ECGs were obtained for heart rate, rhythm, and conduction intervals. Atrial, atrioventricular, and ventricular conduction parameters and refractoriness were assessed in 22 MyBP-C t/t , 10 MyBP-C t/+ , and 17 wild-type MyBP-C +/+ mice with endocardial pacing and intracardiac electrogram recording. Arrhythmia induction was attempted with standardized programmed stimulation at baseline and with isoproterenol. Heart rate variability and ambient arrhythmia activity were assessed with telemetric ECG monitors. Quantitative histological characterization was performed on serial sections of excised hearts. MyBP-C t/t and MyBP-C t/+ mice have normal ECG intervals and sinus node, atrial, and ventricular conduction and refractoriness. Ventricular tachycardia was reproducibly inducible in 14 of 22 MyBP-C t/t mice (64%) during programmed stimulation, compared with 2 of 10 MyBP-C t/+ mice (20%) and 0 of 17 wild-type controls ( P &lt;0.001). Ventricular ectopy was present only in MyBP-C t/t mice during ambulatory ECG recordings. There were no differences in heart rate variability parameters. Interstitial fibrosis correlated with genotype but did not predict arrhythmia susceptibility within the MyBP-C t/t group. Conclusions MyBP-C t/t mice, despite prominent histopathology and ventricular dysfunction, exhibit normal conduction and refractoriness, yet are vulnerable to ventricular arrhythmias. Somatic influences between genetically identical mutant mice most likely account for variability in arrhythmia susceptibility. A sarcomeric protein gene mutation leads to a dilated cardiomyopathy and ventricular arrhythmia vulnerability phenotype.
Prenatal Diagnosis of Chronic Granulomatous Disease
Authors: Peter E. Newburger, Harvey J. Cohen, Susan B. Rothchild, John C. Hobbins, Stephen E. Malawista, Maurice J. Mahoney
Journal: New England Journal of Medicine (1979)

CHRONIC granulomatous disease of childhood is a disorder characterized by chronic recurrent infections beginning in the first year of life and resulting in death by the age of seven in one third of affected patients.1 The disease results from a functional defect in polymorphonuclear leukocytes and monocytes, which ingest normally but fail to kill certain bacteria and fungi.2 The metabolic defect is an inability to generate superoxide free radicals and related toxic oxygen species.3 , 4 There is a male-to-female case ratio of seven to one, reflecting the predominance of families with X-linked over autosomal recessive inheritance.The nitroblue tetrazolium slide test . . .
Risk stratification using a new prognostic score for patients with secondary acute myeloid leukemia: results of the prospective AML96 trial
Authors: F Stölzel, M Pfirrmann, W E Aulitzky, M Kaufmann, H Bodenstein, M Bornhäuser, C Röllig, M Kramer, B Mohr, U Oelschlägel, N Schmitz, S Soucek, C Thiede, G Ehninger, M Schaich
Journal: Leukemia (2010)
Autoantigenic targets of B-cell receptors derived from chronic lymphocytic leukemias bind to and induce proliferation of leukemic cells
Authors: Carsten Zwick, Natalie Fadle, Evi Regitz, Maria Kemele, Stephan Stilgenbauer, Andreas Bühler, Michael Pfreundschuh, Klaus-Dieter Preuss
Journal: Blood (2013)
Lysine Glutarylation Is a Protein Posttranslational Modification Regulated by SIRT5
Authors: Minjia Tan, Chao Peng, Kristin A. Anderson, Peter Chhoy, Zhongyu Xie, Lunzhi Dai, Jeongsoon Park, Yue Chen, He Huang, Yi Zhang, Jennifer Ro, Gregory R. Wagner, Michelle F. Green, Andreas S. Madsen, Jessica Schmiesing, Brett S. Peterson, Guofeng Xu, Olga R. Ilkayeva, Michael J. Muehlbauer, Thomas Braulke, Chris Mühlhausen, Donald S. Backos, Christian A. Olsen, Peter J. McGuire, Scott D. Pletcher, David B. Lombard, Matthew D. Hirschey, Yingming Zhao
Journal: Cell Metabolism (2014)
Transforming growth factor-beta and suppression of humoral immune responses in HIV infection.
Authors: J Kekow, W Wachsman, J A McCutchan, W L Gross, M Zachariah, D A Carson, M Lotz
Journal: Journal of Clinical Investigation (1991)

We reported previously that PBMC from HIV+ patients spontaneously release increased levels of TGF beta 1, contributing to defects in cellular immune responses. This study defines the implications of TGF beta overexpression for humoral immunity in HIV infection. We found that upon Staphylococcus aureus Cowan I (SAC) stimulation of cells from HIV+ donors, B-lymphocyte proliferative responses were decreased. This deficiency correlated closely (r = 0.7, P less than 0.001) with increased TGF beta secretion by PBMC from HIV-infected donors. Conditioned medium from HIV+ PBMC and purified TGF beta 1 had similar inhibitory effects on SAC- or EBV-induced B-cell proliferation, and B cells from HIV-infected donors were as sensitive to inhibition by TGF beta as cells from normal donors. Antibodies to TGF beta 1 neutralized the inhibitory effect of HIV+ culture supernatants on normal B cells and increased low proliferative responses by HIV+ cells. Using PWM as stimulus for B cell differentiation, it was shown that activated TGF beta from HIV+ PBMC is able to significantly reduce the induction of immunoglobulins and this effect was also abrogated by anti-TGF beta. These studies support the concept that in HIV infection, TGF beta is a potent suppressor, not only of the cellular, but of the humoral immune responses as well.
GW25-e3089 Bleeding outcomes in low-mediate risk acute coronary syndrome patients receiving stenting predicted by adenosine diphophate induced platelet aggregation after initiation of clopidogrel: 6 months follow-up
Authors: Cui Tongtao, Huimin Yu, Taiming Dong, Bin Zhang, Hong Yan, Handong Wu, Hongtao Liao, Lijun Jin
Journal: Journal of the American College of Cardiology (2014)
Circulatory Changes Produced by the Valsalva Maneuver in Normal Subjects, Patients with Mitral Stenosis, and Autonomic Nervous System Alterations
Authors: H. D. MCINTOSH, J. F. BURNUM, J. B. HICKAM, J. V. WARREN
Journal: Circulation (1954)

The cardiac output has been measured during the immediate post-Valsalva maneuver recovery period in normal subjects, patients with clinically significant mitral stenosis, and patients with alterations of the autonomic nervous system. When compared with the resting value, it was found that normal subjects had a decrease in cardiac output during the immediate post-Valsalva recovery period, while patients with mitral stenosis had an increased output following the same stress. Three patients with alterations of the autonomic nervous system had a variable response. Changes in total peripheral vascular resistance usually were directionally opposite to changes in the cardiac output. The difficulties of attaching clinical significance to a patient's response to the Valsalva maneuver are considered.
Epidemiological Study on Allergy and Asthma Phenotypes: Sub-clinical and Severe Asthma
Authors: C. D'Ambrosio, P. Pierimarchi, M. Bresciani, C. Parisi, D. Spina, A. Torre, M. Turbati, G. Rasi, S. Bonini
Journal: Journal of Allergy and Clinical Immunology (2006)
Abstract A10: Stromal CAIX expression in oral squamous cell carcinoma and corresponding lymph node metastases
Authors: Shamir Chandarana, Pinaki Bose, Alexander C. Klimowicz, Stephanie K. Petrillo, Mie Konno, Luke Rudmik, Steven C. Nakoneshny, Wayne T. Matthews, Anthony M. Magliocco, Joseph C. Dort, Nigel T. Brockton
Journal: Cancer Research (2013)

Abstract Background: Hypoxia is an almost ubiquitous feature of human solid tumours. However, the direct measurement of oxygen concentration in head and neck squamous cell carcinoma (HNSCC) has been conducted almost exclusively in the metastatic lymph nodes, not the primary tumor. Hypoxia is associated with resistance to both radiotherapy (RT) and chemotherapy in squamous cell cancers (SCCs). However, endogenous markers of hypoxia (EMH) have not reproducibly predicted clinical outcome. However, historically, the method used to assign hypoxic status according to directly measured oxygen concentration (polarographic electrode) and EMH (typically immunohistochemistry) have fundamentally differed. Methods: Demographic data and clinical outcomes of 61 patients with oral squamous cell carcinoma (OSCC) treated with primary surgery +/- adjuvant radiation were collected. Tissue microarray's with representative samples of patients' tumors were constructed from paraffin-embedded blocks. Automated quantitative immunohistochemistry (AQUA) was performed to measure expression and distribution of carbonic anhydrase IX (CAIX). Kaplan-Meier survival analysis and the log-rank test was used to assess the impact of vimentin-defined stromal CAIX (in both primary tumor and nodal metastases) on survival. Results: High stromal CAIX expression in the primary tumor was associated with significantly worse 5-year disease-specific survival. There was a statistically significant but relatively weak correlation between stromal CAIX expression in the primary tumor and the corresponding lymph nodes (r2:0.359; p=0.013). Stromal CAIX expression in the lymph node metastases was not significantly associated with 5-year disease-specific survival. Conclusions: Previous literature presenting the prognostic impact of directly measured hypoxia, using a polarographic electrode, was based predominantly on measurements from lymph nodes, not the primary tumor. Furthermore, comparisons with EMH were based solely on percentage of tumor cells that were positively stained, not the intensity of staining. We present the results of a tumor comparment-specific, quantitative fluorescent IHC method and the survival associated with EMH in the tumor microenvironment in the primary tumor and lymph node metastases. Citation Format: Shamir Chandarana, Pinaki Bose, Alexander C. Klimowicz, Stephanie K. Petrillo, Mie Konno, Luke Rudmik, Steven C. Nakoneshny, Wayne T. Matthews, Anthony M. Magliocco, Joseph C. Dort, Nigel T. Brockton. Stromal CAIX expression in oral squamous cell carcinoma and corresponding lymph node metastases. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Invasion and Metastasis; Jan 20-23, 2013; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2013;73(3 Suppl):Abstract nr A10.
1166 CLINICAL RELEVANCE OF MINIMAL RESIDUAL VIREMIA DETECTED WITH THE ABBOTT REALTIME HCV ASSAY FOR RESPONSE-GUIDED THERAPY WITH PEG-INTERFERON-a/RIBAVIRIN IN PATIENTS WITH HEPATITIS-C-VIRUS GENOTYPE 1 INFECTION
Authors: J. Vermehren, S. Süsser, D. Perner, C. Füller, S. Zeuzem, C. Sarrazin
Journal: Journal of Hepatology (2012)
Amyloidosis in Rheumatoid Arthritis: INVESTIGATED BY MEANS OF RECTAL BIOPSY
Authors: G. Arapakis, C. R. Tribe
Journal: Annals of the Rheumatic Diseases (1963)

The types of disease associated with secondary amyloidosis have undergone considerable change in recent years.Largely because of modern antibiotic treatment, amyloidosis associated with tuberculosis, osteomyelitis, chronic lung disease, and syphilis is now rarely seen.For this reason rheumatoid arthritis is now one of the commonest causes of secondary amyloidosis.Although amyloidosis may be suspected on clinical or biochemical grounds, a definite diagnosis can only be made by tissue biopsy or post mortem.Most investigations of the incidence of amyloidosis in patients with rheumatoid arthritis have been based on post mortem studies.Missen and Taylor (1956), in reviewing the literature, found a wide variation in the reported incidence.The highest incidence-60 per cent.-was reported by Teilum and Lindahl (1954), whereas Rosenberg, Baggen- stoss, and Hench (1943) had found only one case of amyloidosis in thirty necropsies on patients with rheumatoid arthritis (3 3 per cent.).This marked discrepancy reveals the limitations inherent in deriving the incidence of a disease from "selected" necropsies.Rectal biopsy has recently been advocated by several authors as the best and most convenient method for the diagnosis of amyloidosis.Blum and Sohar (1962) obtained positive results in 75 per cent. of a series of 62 patients with amyloidosis already diagnosed by other methods.In this paper we describe the results of rectal biopsy used as a screening test for amyloidosis in a random population of patients with rheumatoid arthritis, the majority of whom were currently under treatment at the Oxford Regional Rheumatism Centre.In addition to the rectal biopsy, other clinical and laboratory data were collected from each patient included in the study. Material and MethodsDuring a period of 4 months rectal biopsy was per- formed on 115 patients who satisfied the criteria of the
Susceptibility to cytotoxic T lymphocyte-induced apoptosis is a function of the proliferative status of the target.
Authors: W K Nishioka, R M Welsh
Journal: The Journal of Experimental Medicine (1994)

Cytotoxic T lymphocytes (CTL) kill cells by perturbing the target's plasma membrane and by inducing the disintegration of the target cell's DNA into oligonucleosomal fragments, a process characteristic of apoptosis. We show that the DNA fragmentation event is distinct from the membrane lysis event and is dependent on the state of target cell activation or commitment into the mitotic cycle. Quiescent cells were refractory to DNA fragmentation, but not to membrane lysis. Log phase growth, transformation with c-myc, or infection of quiescent G0 targets with herpes simplex virus-1, which induces a competent state for DNA synthesis, all enhanced target cell susceptibility to CTL-induced DNA fragmentation without altering the membrane lysis. These results suggest that G0 cells are resistant to CTL-induced apoptosis, but that entry into G1 or a G1-like state by growth factors, cellular transformation, or DNA virus infection renders them competent to enter the apoptotic pathway(s).
919 THYROID-STIMULATING HORMONE SERUM LEVEL, LIVER THYROID-STIMULATING HORMONE-RECEPTOR, AND SEVERE FIBROSIS IN GENOTYPE 1 CHRONIC HEPATITIS C PATIENTS WITH NORMAL THYROID FUNCTION
Authors: S. Petta, A. Mazzola, S. Grimaudo, C. Camma, D. Cabibi, V. Di Marco, G.C. Monreale, R.M. Pipitone, A. Craxi
Journal: Journal of Hepatology (2012)
Managing chronic disease
Authors: I. Loefler
Journal: BMJ (2001)

All living things die. In nature, untrammelled, the common agents of death are trauma (being eaten is the commonest variety), deprivation, infection, and poisons.

> Health for all is unattainable. A disease-free world is an illusion 

Culture is to a large extent concerned with death. It tries to explain it; often it tries to present it as an event which is not final and rather promising. Nevertheless, culture makes immense efforts to postpone death.

Medical care is central to contemporary culture. Its importance is steadily growing because, for the first time in history, medical care has an impact. Life expectancy is increasing as the direct result of therapeutic rather than preventive and promotive activities. We have learnt to cure many fatal conditions, and we have learnt to manage chronic illness.

Life expectancy is looked on as a measure of civilisation, if not the principal index of cultural achievement. Yet long life can be mistaken for a sign of health. Until recently …
GM-CSF Treatment and Hypokalemia
Authors: P. Viens
Journal: Annals of Internal Medicine (1989)

Letters and Corrections1 August 1989GM-CSF Treatment and HypokalemiaP. Viens, MD, A. Thyss, MD, G. Garnier, MD, P. Ayela, MD, M. Lagrange, MD, M. Schneider, MDP. Viens, MDSearch for more papers by this author, A. Thyss, MDSearch for more papers by this author, G. Garnier, MDSearch for more papers by this author, P. Ayela, MDSearch for more papers by this author, M. Lagrange, MDSearch for more papers by this author, M. Schneider, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-111-3-263_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: Granulocyte-macrophage colony-stimulating factor (GM-CSF) is currently proposed as a means for accelerating hematopoietic recovery after aplasia-inducing chemotherapy (1, 2) and as an agent for treating myelodysplasias (3). The various side effects described are rarely of a metabolic nature. We report a case of severe acute hypokalemia in a patient treated with GM-GSF.A 79-year-old woman was hospitalized for GM-CSF treatment (GM-CSF obtained from Cho-Cell, Sandoz Pharmaceuticals, Basel, Switzerland) because of refractory anemia with excess blast cells as defined by the FAB (French American British Cooperative) requiring erythrocyte transfusions every 4 weeks (randomized study of the Leukemia group...References1. BrandtPetersAtwater SPS. Effect of recombinant human granulocyte-macrophage colony-stimulating factor on hematopoietic reconstitution after high-dose chemotherapy and autologous bone marrow transplantation. N Engl J Med. 1988;318:869-76. CrossrefMedlineGoogle Scholar2. AntmanGriffinElias KJA. Effect of recombinant human granulocyte-macrophage colony-stimulating factor on chemotherapy-induced myelosuppression. N Engl J Med. 1988;319:593-8. CrossrefMedlineGoogle Scholar3. Vadhan-RajKeatingLeMaistre SMA. Effects of recombinant human granulocyte-macrophage colony-stimulating factor in patients with myelodysplastic syndromes. N Engl J Med. 1987;317:1545-52. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Centre Antoine-Lacassagne Nice France PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByGranulocyte–macrophage colony-stimulating factor (GM-CSF)Drug-induced hypokalaemiaCYTOKINES AND CYTOKINE MODULATORSGranulocyte–macrophage colony-stimulating factor (GM-CSF)Blood and blood productsColony-stimulating factorsGranulocyte-Macrophage Colony-Stimulating Factor (GM-CSF), Hypocalcemia, and HypomagnesemiaM. N. Potter, MB, M. G. Mott, MB, A. Oakhill, MBBlood and blood products 1 August 1989Volume 111, Issue 3Page: 263-263KeywordsAnemiaCellsChemotherapyGranulocyte macrophage colony stimulating factor Issue Published: 1 August 1989 PDF DownloadLoading ...
Effect of heart rate on regional coronary blood flow
Authors: R. J. DOMENECH, J. GOICH
Journal: Cardiovascular Research (1976)

The effect of tachycardia on the distribution of coronary blood flow was studied in the dog heart using the radioactive microsphere technique. Increasing heart rate from 1.7 to 3.0 Hz produced an increment of flow to the inner and outer layer of both ventricular walls. However, the flow ratio, inner layer to outer layer, increased in the right ventricular wall and decreased in the left wall. Measurements performed in ventricular regions with previous vasodilatation and during right ventricular hypertension revealed that the comparatively larger vasodilatation reserve of the right ventricular subendocardium is due to the lower pressure this ventricle develops normally.
Role of Progesterone Receptors In Breast Cancer
Authors: W. L. McGuire, G. M. Clark
Journal: CA A Cancer Journal for Clinicians (1986)

It has been demonstrated that progesterone receptors (PRs) are at least as valuable as estrogen receptors (ERs) for predicting outcome in breast cancer patients. Retrospective analysis indicates that the presence of PRs may be the second most critical factor, after the number of positive nodes, in predicting disease-free survival, with a correlation between length of survival and number of tumor PRs. The presence of PRs has been shown to be of value for predicting response in both early and advanced breast cancer patients. In studies of assay consistency, major discordance rates were minimal in simultaneous assays, but extremely high in sequential assays of tumors that were PR-positive in initial assay. The responsible factor was interim endocrine therapy, and it was subsequently determined that the prognosis was worse for those patients whose tumors lost PR between assays.
A randomized trial of ribavirin and interferon-α vs. interferon-α alone in patients with chronic hepatitis C who were non-responders to a previous treatment
Authors: Stanislas Pol, Patrice Couzigou, Marc Bourlière, Armand Abergel, Jean-Marc Combis, Dominique Larrey, Albert Tran, Joseph Moussalli, Raoul Poupon, Pierre Berthelot, Christian Bréchot
Journal: Journal of Hepatology (1999)
HEALING OF TUBERCULOUS CAVITIES
Authors: L. S. T. Burrell
Journal: BMJ (1935)

A cavity in a tuberculous lung is a source of danger, and adds to the gravity of the prognosis.At the same time a large number of cavities heal without any form of collapse treatment.The modern view that a cavity must be collapsed at all costs is open to the criticism that the danger of the treatment sometimes exceeds that of the disease.It is usually good treatment to try and collapse a cavity by artificial pneumothorax, but if this fails it does not follow that surgical methods, such as thoracoplasty or plombage, should be tried.
New cancer strategy for England focuses on earlier diagnosis
Authors: S. Mayor
Journal: BMJ (2011)

The UK government has published a new strategy to improve the early detection and treatment of cancer in England, with the aim of increasing survival rates—which currently lag behind those in many other countries—to match the best achieved in Europe by 2014-15.

Launching the strategy, the health secretary for England, Andrew Lansley, said, “Our ambition is simple, to deliver survival rates among the best in Europe, and this strategy outlines how we will make our first steps towards this.” He said the aim is to reduce the number of deaths from cancer by 5000 each year from 2014-15.

The strategy sets out a range of actions to improve cancer outcomes, including measures to diagnose cancer earlier. GPs will be given greater direct access to tests, including chest radiography, non-obstetric ultrasonography, flexible sigmoidoscopy and colonoscopy, and brain magnetic resonance imaging, for patients with symptoms that might be caused by cancer.

To improve early diagnosis of cervical cancer, women with mild or borderline abnormal test results of cervical screening will be offered testing for human papilloma virus.

Mike Richards, the national clinical director for cancer, said, “We know the main reason our survival rates lag behind other countries’ is because too many people are diagnosed late.” Latest figures from the National Cancer Intelligence Network show that around one quarter of cancer patients in the UK are diagnosed as …