tbuckley/cabot-search huggingface dataset:
Donor Lymphocyte Infusion Induces Polyspecific CD8<sup>+</sup> T-Cell Responses With Concurrent Molecular Remission in Acute Myeloid Leukemia With <i>NPM1</i> Mutation
Authors: Susanne Hofmann, Marlies Götz, Vanessa Schneider, Philippe Guillaume, Donald Bunjes, Hartmut Döhner, Markus Wiesneth, Jochen Greiner
Journal: Journal of Clinical Oncology (2012)
CD4+ T Cell Tolerance to Parenchymal Self-Antigens Requires Presentation by Bone Marrow–derived Antigen-presenting Cells
Authors: Adam J. Adler, David W. Marsh, Gregory S. Yochum, James L. Guzzo, Ankesh Nigam, William G. Nelson, Drew M. Pardoll
Journal: The Journal of Experimental Medicine (1998)

T cell tolerance to parenchymal self-antigens is thought to be induced by encounter of the T cell with its cognate peptide-major histocompatibility complex (MHC) ligand expressed on the parenchymal cell, which lacks appropriate costimulatory function. We have used a model system in which naive T cell receptor (TCR) transgenic hemagglutinin (HA)-specific CD4+ T cells are adoptively transferred into mice expressing HA as a self-antigen on parenchymal cells. After transfer, HA-specific T cells develop a phenotype indicative of TCR engagement and are rendered functionally tolerant. However, T cell tolerance is not induced by peptide-MHC complexes expressed on parenchymal cells. Rather, tolerance induction requires that HA is presented by bone marrow (BM)-derived cells. These results indicate that tolerance induction to parenchymal self-antigens requires transfer to a BM-derived antigen-presenting cell that presents it to T cells in a tolerogenic fashion.
British women are engaging in greater variety of sexual practices
Authors: I. Torjesen
Journal: BMJ (2013)

Great Britain is becoming more accepting of sexual diversity, and women in particular are now more open to participating in more diverse sexual behaviours, especially well educated and wealthier women, show the latest results of the largest survey of sexual attitudes and behaviour in England, Scotland, and Wales.

Over the past 20 years women have become four times more likely to have had a same sex sexual encounter, and they now have on average more than twice the number of sexual partners in their lifetime than they did in 1990.

Narrowing of the gap between the sexes in sexual views and behaviours is not the only change that has taken place since the first National Survey of Sexual Attitudes and Lifestyles (Natsal) survey was conducted in 1990-1. The latest results of the survey, which takes place every 10 years, were published in six research papers and a commentary in the Lancet on Tuesday (www.thelancet.com/themed/natsal). They show that people in Britain are having sex less often, because they are less likely to be living with their sexual partner and because of the pressure of modern life.

Over 15 000 adults aged 16-74 years were interviewed in England, Scotland, and Wales between September 2010 and August 2012 about their sexual behaviour, attitudes, and health and wellbeing for the third Natsal study.

Commenting on the reduction in the frequency of sex—from more than …
Mammalian Sterile 20–like Kinase 1 Suppresses Lymphoma Development by Promoting Faithful Chromosome Segregation
Authors: Tae-Shin Kim, Da-Hye Lee, Sang Kyum Kim, So Youn Shin, Eul-Ju Seo, Dae-Sik Lim
Journal: Cancer Research (2012)

Abstract The mammalian Hippo signaling pathway has been implicated in oncogenesis in the context of solid tumors such as hepatocellular carcinoma. Mammalian sterile 20–like kinase 1 (MST1), the core component of the Hippo signaling pathway, is highly expressed in hematopoietic cells. However, its possible impact on tumorigenesis in this setting is unknown. In this study, we provide evidence that Mst1 loss in the mouse enhances chemically and genetically induced lymphoma development by inducing chromosomal instability. Mst1 deficiency increased susceptibility to T-cell acute lymphoblastic leukemia induced by mutagen exposure. Notably, before transformation Mst1−/− normal thymocytes showed no changes in proliferation or apoptosis in vitro and in vivo, but they displayed elevated levels of abnormal mitotic chromosomes and aneuploidy, conditions known to promote tumorigenesis. Mst1−/− mice also showed accelerated formation of spontaneous lymphomas in a p53-deficient background, accompanied by severe aneuploidy. In clinical specimens of lymphoma and leukemia, we documented frequent downregulation of MST1 expression, consistent with our findings. Taken together, our findings reveal a tumor suppressive function of Mst1 based on its ability to prevent chromosomal instability in lymphocytes. Cancer Res; 72(20); 5386–95. ©2012 AACR.
Frequency and risk factors of recurrent pain during refeeding in patients with acute pancreatitis: a multivariate multicentre prospective study of 116 patients.
Authors: P Levy, D Heresbach, E A Pariente, A Boruchowicz, R Delcenserie, B Millat, J Moreau, L Le Bodic, L de Calan, M Barthet, A Sauvanet, P Bernades
Journal: Gut (1997)

BACKGROUND/AIMS: The period of refeeding in patients with acute pancreatitis is critical because they may have pain relapse. A multicentre, multidimensional, prospective study was performed to assess the frequency and the risk factors of pain relapse in these patients. METHODS: Patients were included if they had acute pancreatitis severe enough to stop oral feeding for more than 48 hours. Clinical, biochemical, radiological, and therapeutic data were prospectively recorded and analysed by unidimensional and multidimensional analysis. The moment to refeed patients was chosen by the clinician but the diet was the same in all centres. RESULTS: A total of 116 patients were included with a Ranson9s bioclinical score &gt; or = 3 in 35% and a Balthazar9s CT score &gt; or = D in 42%. The cause of acute pancreatitis was biliary in 47% and alcohol misuse in 31%. During the oral refeeding period, 21% of the patients had pain relapse. This occurred on days 1 and 2 in 50% of patients. The duration of the painful period was longer in patients who relapsed than in others (p &lt; 0.002). Pain relapse occurred in 39% of patients with a serum lipase concentration &gt; 3x the upper limit of the normal range the day before refeeding and in 16% of other patients (p &lt; 0.03). Patients with higher Balthazar9s CT scores had pain relapse more often than the others (p &lt; 0.002). None of the therapeutic procedures significantly modified the frequency of pain relapse. Using multidimensional analysis, Balathazar9s CT score, period of pain, and serum lipase concentration the day before refeeding were independently associated with an increased risk of pain relapse. At a threshold of 0.5, a logistic score had a 37% sensitivity, 95% specificity, and 83% accuracy to predict pain relapse. Pain relapse nearly doubled total hospital stay and hospital stay after the first attempt at oral refeeding. CONCLUSION: Pain relapse occurred in one fifth of the patients with acute pancreatitis during oral refeeding and was more common in patients with necrotic pancreatitis and with longer periods of pain. The results of this study can be used to predict high risk patients and are a first step in the prevention of pain relapse.
Eye injuries in sport: an increasing problem.
Authors: N P Jones
Journal: British Journal of Sports Medicine (1987)

A prospective study of ocular injuries sustained during sport, was performed from January to June 1987. A total of 84 eye injuries were seen. Of these, 23 were severe enough to necessitate admission to hospital. These latter accounted for one quarter of all severe eye injuries during this period. Racquet sports caused 42% of the injuries, and 57% of the hospital admissions, including two penetrating injuries. The importance of sport in causing eye trauma is increasing. It is crucial to encourage safer play, including the wearing of adequate eye protection.
Epilepsy and Its Treatment.
Authors: William Philip Spratling
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The airway smooth muscle CCR3/CCL11 axis is inhibited by mast cells
Authors: R. Saunders, A. Sutcliffe, L. Woodman, D. Kaur, S. Siddiqui, Y. Okayama, A. Wardlaw, P. Bradding, C. Brightling
Journal: Allergy (2008)

Background: Airway smooth muscle hyperplasia is a feature of asthma, and increases with disease severity. CCR3‐mediated recruitment of airway smooth muscle progenitors towards the airway smooth muscle bundle has been proposed as one possible mechanism involved in airway smooth muscle hyperplasia. Mast cells are microlocalized to the airway smooth muscle bundle and whether mast cells influence CCR3‐mediated migration is uncertain. Methods: We examined the expression of CCR3 by primary cultures of airway smooth muscle cells from asthmatics and nonasthmatics. CCR3 function was examined using intracellular calcium measurements, chemotaxis, wound healing, cell proliferation and survival assays. We investigated the recovery and function of both recombinant and airway smooth muscle‐derived CCL11 (eotaxin) after co‐culture with β‐tryptase and human lung mast cells. Results: Airway smooth muscle expressed CCR3. Airway smooth muscle CCR3 activation by CCL11 mediated intracellular calcium elevation, concentration‐dependent migration and wound healing, but had no effect on proliferation or survival. Co‐culture with β‐tryptase or mast cells degraded recombinant and airway smooth muscle‐derived CCL11, and β‐tryptase inhibited CCL11‐mediated airway smooth muscle migration. Conclusions: CCL11 mediates airway smooth muscle migration. However co‐culture with β‐tryptase or mast cells degraded recombinant and airway smooth muscle‐derived CCL11 and inhibited CCL11‐mediated airway smooth muscle migration. Therefore these findings cast doubt on the importance of the CCL11/CCR3 axis in the development of airway smooth muscle hyperplasia in asthma.
THE TREATMENT OF TABETIC ATAXIA
Authors: J. G. Garson
Journal: BMJ (1912)

JOUIRNAL of August 26th, 1911, 1 demonstrated clinically'the beneficial effects I had obtained'in tabes dorsalis, even when marked ataxia had occurred, from' systematic prac- tice of the exercises designed by Frenkel of' Heiden for restoring the power of co-ordinate movement.Sinice then I have received many inquiries respecting the treatment and also on points not included in my former communication.It is'gratifying' to find so much interest evinced in this successful method,' offered by the Frenkel system, of mitigating the unhappy condition of patients suffering from this disabling affection.Yet the correspondence also shows that there still exists a good deal of misapprehension regarding the nature and practical application of the exercises, as well as the training through which the patient must go to produce the restults desired.It is to these considerations that I propose' more particu- larly to address myself on the'present occasion.
Generalized anxiety disorder: diagnosis and treatment
Authors: E. A. Hoge, A. Ivkovic, G. L. Fricchione
Journal: BMJ (2012)

#### Summary points

Generalized anxiety disorder (GAD) is relatively common, with lifetime prevalence rates of 4-7%. It is a disorder of chronic uncontrollable worry, compounded by physiological symptoms such as disturbed sleep, muscle tension, and difficulty concentrating. The disorder is associated with seriously impaired social and occupational functioning, comorbidity with other disorders, and increased risk for suicide.1 GAD can go undiagnosed because of a focus on physical symptoms and because of the stigma of mental illness. However, the disorder can be treated. This article reviews current knowledge about the diagnosis and treatment of GAD, including pharmacotherapy and psychosocial therapies.

#### Sources and selection criteria

We based this review on articles found by searching PubMed and the Cochrane Database of Systematic Reviews using the terms “generalized anxiety disorder” and “generalised anxiety disorder”. Our search was limited to English language articles published between 2005 and 2012. Meta-analyses, reviews, and randomised controlled trials were prioritized.

GAD is characterized by excessive worry and symptoms of physiological arousal such as restlessness, insomnia, and muscle tension (box). To meet Diagnostic and Statistical Manual of Mental Disorders , fourth edition (DSM-IV) criteria for the disorder, the patient must have excessive and difficult to control anxiety about several different events or activities.2 For example, anxiety confined to concern about personal safety would not qualify (but should elicit inquiries about symptoms of post-traumatic stress disorder or agoraphobia, for example). In addition to worry, patients must have at least three of the six physiological arousal symptoms listed in the box. …
Cardiac Rehabilitation Attendance and Outcomes in Coronary Artery Disease Patients
Authors: Billie-Jean Martin, Trina Hauer, Ross Arena, Leslie D. Austford, P. Diane Galbraith, Adriane M. Lewin, Merril L. Knudtson, William A. Ghali, James A. Stone, Sandeep G. Aggarwal
Journal: Circulation (2012)

Background— Cardiac rehabilitation (CR) is an efficacious yet underused treatment for patients with coronary artery disease. The objective of this study was to determine the association between CR completion and mortality and resource use. Methods and Results— We conducted a prospective cohort study of 5886 subjects (20.8% female; mean age, 60.6 years) who had undergone angiography and were referred for CR in Calgary, AB, Canada, between 1996 and 2009. Outcomes of interest included freedom from emergency room visits, hospitalization, and survival in CR completers versus noncompleters, adjusted for clinical covariates, treatment strategy, and coronary anatomy. Hazard ratios for events for CR completers versus noncompleters were also constructed. A propensity model was used to match completers to noncompleters on baseline characteristics, and each outcome was compared between propensity-matched groups. Of the subjects referred for CR, 2900 (49.3%) completed the program, and an additional 554 subjects started but did not complete CR. CR completion was associated with a lower risk of death, with an adjusted hazard ratio of 0.59 (95% confidence interval, 0.49–0.70). CR completion was also associated with a decreased risk of all-cause hospitalization (adjusted hazard ratio, 0.77; 95% confidence interval, 0.71–0.84) and cardiac hospitalization (adjusted hazard ratio, 0.68; 95% confidence interval, 0.55–0.83) but not with emergency room visits. Propensity-matched analysis demonstrated a persistent association between CR completion and reduced mortality. Conclusions— Among those coronary artery disease patients referred, CR completion is associated with improved survival and decreased hospitalization. There is a need to explore reasons for nonattendance and to test interventions to improve attendance after referral.
A NOTE ON FORMALIN IODINE CATGUT
Authors: F. J. Steward
Journal: BMJ (1909)

TNITMXBJs FORMALIN IODINE CATGUT."[OCT.2, T909.which may develop and assume the importance of a cervical rib.There are, accordini to Tarner, four types of cervical rib-namely, three' incomplete varieties, and one complete, so-called according to the extent of development:1. Cases in which the costal element is represented by a small projection not much larger than a transverse process..2: Those in which the costal element is still longer, and whose end is free or attached to the first rib.3. Those in which the cervical rib is long enough to find attachment to the costal cartilage of the first rib.4. Those in which the cervical rib actually joins the manubrium sterni, either alone or in conjunction with the first rib.
Differences in Antibody Response to Streptococcal Antigens in Children with Rheumatic and Non-rheumatic Mitral Valve Disease
Authors: STANFORD T. SHULMAN, ELIA M. AYOUB, BENJAMIN E. VICTORICA, IRA H. GESSNER, DOLORES F. TAMER, FRANCISCO A. HERNANDEZ
Journal: Circulation (1974)

The usefulness of streptococcal antibody tests — anti-streptolysin O (ASO), anti-desoxyribonuclease B (anti-DNAse B), and anti-group A carbohydrate (A-antibody) — in differentiating rheumatic from non-rheumatic mitral disease was explored. Sera from 154 children with mitral disease were studied. Fifteen of 17 patients with chronic mitral insufficiency (MI) following acute rheumatic fever manifested persistence of elevated A-antibody levels following the decline of ASO and anti-DNAse B titers to normal 18-36 months after their acute illness. This antibody pattern was not observed among sera from 35 patients with congenital mitral valve deformities. Serologic study of 71 children with mitral disease of obscure etiology identified three groups: subgroup A includes those 12 who demonstrated the antibody pattern associated with rheumatic MI, while subgroup B is comprised of 39 children with normal A-antibody levels. Twenty patients (subgroup C) manifested evidence of recent streptococcal infection. These data suggest that the use of the A-antibody test in conjunction with other streptococcal antibody tests is of potential value in differentiating rheumatic from non-rheumatic mitral disease.
What's the E for EBM?
Authors: Sharon E Straus
Journal: BMJ (2004)

Most neurophysiological signals exhibit slow continuous trends over time. Because standard correlation analyses assume that all samples are independent, they can yield apparently significant "nonsense correlations" even for signals that are completely unrelated. Here we compare the performance of several methods for assessing correlations between timeseries, using simulated slowly drifting signals with and without genuine correlations. The best performance was obtained from a "pseudosession method", which relies on one of the signals being randomly generated by the experimenter, or a "session perturbation" method which requires multiple recordings under the same conditions. If neither of these is applicable, we find that a "linear shift method can work well, but only when one of the signals is stationary. Methods based on cross-validation, circular shifting, phase randomization, or detrending gave up to 100% false positive rates in our simulations. We conclude that analysis of neural timeseries is best performed when stationarity and randomization is built into the experimental design.
James Maxwell Jones
Authors: Doreen Jones
Journal: BMJ (2005)

Former general practitioner Bridport and London, and medical missionary Lesotho (b China 1915; q King's College Hospital, London, 1938; FRCS Ed), d 4 December 2004.

James Maxwell Jones was called up into the Royal Air Force Volunteer Reserve in 1940 and served as a medical officer until 1946, when he returned to general practice in Bridport. From 1961 to 1967 he worked at the Bethnal Green Medical Mission, London, before spending a year at St James's Mission Hospital, Lesotho, southern Africa, 7200 feet up in the Malute Mountains. His first wife died in Lesotho and he returned to the United Kingdom in 1969, working at the Islington Medical Centre, London, and the Bermondsey Medical Mission, until retirement from full practice in 1980. His Christian faith sustained him. He leaves his second wife, Doreen; six children; and 11 grandchildren.
TCT-517 Reduction of Hospitalization and Duration of Anticoagulation for Deep Venous Thrombosis in Patients Undergoing Percutaneous Endovenous Intervention and Receiving Novel Anticoagulants
Authors: Mohsen Sharifi, Wilbur K. Freeman, Nikki Rezania, Tahereh Emami, Jean Chatham, Frederic Schwartz
Journal: Journal of the American College of Cardiology (2013)
Exhibit Explores Link Between Art and Epilepsy
Authors: Paul Cotton
Journal: JAMA (1994)

ELECTRICAL STORMS in the cortex, known to science as temporal lobe epilepsy (TLE), sometimes bring cognitive rains that nurture art. Perhaps it is not surprising that such a phenomenon in the part of the brain thought to be the seat of conscious awareness would have an impact on creativity. The functions of this part of the brain include vision, emotion, movement, sensation, hearing, spatial perception, and "everything else that we consciously experience day in and day out," says Steven C. Schachter, MD, an assistant professor of neurology at Harvard Medical School and senior neurologist at Beth Israel Hospital, Boston, Mass. He is also president of the Massachusetts chapter of the Epilepsy Foundation. The relationship between art and epilepsy, between seizure and creativity, is explored in an exhibit called "From the Storm: Artists With Temporal Lobe Epilepsy." It includes works from more than two dozen artists with TLE, painters, sculptors, poets,
Marburg I Polymorphism of Factor VII–Activating Protease
Authors: Johann Willeit, Stefan Kiechl, Thomas Weimer, Artur Mair, Peter Santer, Christian J. Wiedermann, Juergen Roemisch
Journal: Circulation (2003)

Atherothrombosis is a main pathomechanism in the evolution of vessel stenosis and is counteracted by endogenous fibrinolysis. Recently, the plasmatic serine protease "factor seven-activating protease" (FSAP) was recognized as a potent activator of prourokinase in vitro. The Marburg I polymorphism of FSAP impairs this potential and may thus facilitate arterial thrombosis.This analysis of the Bruneck Study involved 810 men and women aged 40 to 79 years. The ultrasound-based atherosclerosis progression model (5-year follow-up) permits differentiation between early atherogenesis and the advanced stenotic stages of carotid artery disease. The FSAP Marburg I polymorphism was found in 37 subjects (carriage rate 4.4%). Individuals with this genetic variant showed a prominently reduced in vitro capacity to activate prourokinase. No relation was found to exist between the Marburg I polymorphism and early atherogenesis. In contrast, it emerged as a strong and independent risk predictor of incident/progressive carotid stenosis (multivariate odds ratio [95%CI], 6.6 [1.6 to 27.7]). This finding equally applied to subjects with and without co-segregation of the Marburg II polymorphism. The risk profile of advanced atherogenesis further includes cigarette smoking, high lipoprotein(a), the factor V Leiden mutation, low antithrombin III, high fibrinogen, and diabetes.In concert with other genetic and acquired conditions known to interfere with coagulation or fibrinolysis, the Marburg I polymorphism of FSAP, which attenuates its capacity to activate prourokinase, is a significant risk predictor for the evolution and progression of carotid stenosis.