Megestrol Acetate for Treatment of Cachexia Associated with Human Immunodeficiency Virus (HIV) Infection
Authors: J. H. Von Roenn, R. L. Murphy, K. M. Weber, L. M. Williams, S. A. Weitzman
Journal: Annals of Internal Medicine (1988)

Brief Reports15 November 1988Megestrol Acetate for Treatment of Cachexia Associated with Human Immunodeficiency Virus (HIV) InfectionJamie H. Von Roenn, MD, Robert L. Murphy, MD, Kathleen M. Weber, RN, BSN, Lisa M. Williams, RN, BSN, Sigmund A. Weitzman, MDJamie H. Von Roenn, MDSearch for more papers by this author, Robert L. Murphy, MDSearch for more papers by this author, Kathleen M. Weber, RN, BSNSearch for more papers by this author, Lisa M. Williams, RN, BSNSearch for more papers by this author, Sigmund A. Weitzman, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-10-840 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCachexia is a common problem in patients infected with human immunodeficiency virus (HIV) and predicts a poor prognosis (1, 2). The deleterious effects of malnutrition on immunity to infection are well recognized (3, 4). Therefore, evaluation of nutritional status and treatment, if indicated, in persons with HIV infection may be particularly important.Recently, megestrol acetate, a synthetic orally active progesterone widely used for the therapy of advanced breast cancer, was reported to stimulate the appetite and produce weight gain (5). On the basis of this information, we initiated megestrol acetate therapy in persons with HIV infection and severe anorexia and...References1. Chlebowski R. Significance of altered nutritional status in acquired immune deficiency syndrome (AIDS). Nutr Cancer. 1985;7:85-91. CrossrefMedlineGoogle Scholar2. O'Sullivan P, Linke R, and Dalton S. Evaluation of body weight and nutritional status among AIDS patients. J Am Diet Assoc. 1985;85:1483-4. CrossrefMedlineGoogle Scholar3. Chandra R. Nutrition, immunity, and infection: present knowledge and future directions. Lancet. 1983;1:688-91. CrossrefMedlineGoogle Scholar4. Chandra R and Scrimshaw N. Immunocompetence in nutritional assessment. Am J Clin Nutr. 1980;33:2694-7. CrossrefMedlineGoogle Scholar5. Tchekmedyian N, Tait N, Moody M, and Aisner J. High-dose megestrol acetate: a possible treatment for cachexia. JAMA. 1987;9:1195-8. CrossrefGoogle Scholar6. Yarchoan R, Klecker R, and Weinhold K. Administration of 3′azido-3′-deoxythymidine, an inhibition of HTLV-III/LAV replication, to patients with AIDS or AIDS-related complex. Lancet. 1986;1:575-80. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Jamie H. Von Roenn, MD; Robert L. Murphy, MD; Kathleen M. Weber, RN, BSN; Lisa M. Williams, RN, BSN; Sigmund A. Weitzman, MDFrom Northwestern University Medical School, Chicago, Illinois. For current author addresses, see end of text. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDrug FormularyGhrelin in Cachexia Associated with End-Stage Renal DiseasePluronic block copolymers and Pluronic poly(acrylic acid) microgels in oral delivery of megestrol acetateReport of a Pilot, Double-Blind, Placebo-Controlled Study of Megestrol Acetate in Elderly Dialysis Patients With CachexiaSustained appetite improvement in malnourished dialysis patients by daily ghrelin treatmentMegestrol acetate in cachexia and anorexiaCancer Anorexia and CachexiaComparing Megestrol Acetate Therapy with Oxandrolone Therapy for HIV‐Related Weight Loss: Similar Results in 2 MonthsTestosterone therapy in HIV wasting syndrome: systematic review and meta-analysisA low-dose adrenocorticotropin test reveals impaired adrenal function in cancer patients receiving megestrol acetate therapyTreatment with Megestrol Acetate Improves Human Immunodeficiency Virus-Associated Immune ThrombocytopeniaA phase II study of low-dose megestrol acetate using twice-daily dosing for anorexia in nonhormonally dependent cancerSupportive use of megestrol acetate (Megace) with head/neck and lung cancer patients receiving radiation therapyImprovement in Quality-of-Life Measures and Stimulation of Weight Gain After Treatment with Megestrol Acetate Oral Suspension in Geriatric Cachexia: Results of a Double-Blind, Placebo-Controlled StudyTreatment Guidelines for HIV-Associated WastingTherapeutic approaches to malnutrition in chronic dialysis patients: The different modalities of nutritional supportTreatment with Progesterone Analogues Decreases Macrophage Fcγ Receptors ExpressionHIV Wasting Syndrome: Treatment UpdateNutritional support of the hospitalized patientMulticentre Study on the Prevalence of Symptoms and Symptomatic Treatment in HIV InfectionMcCollum Award Lecture, 1996: protein-energy malnutrition in maintenance dialysis patientsEffect of megestrol acetate and prepulsid on nutritional improvement in patients with head and neck cancers undergoing radiotherapyAGA technical review: Malnutrition and cachexia, chronic diarrhea, and hepatobiliary disease in patients with human immunodeficiency virus infectionPediatric human immunodeficiency virus infectionHyperglycemia Induced by Megestrol Acetate in a Patient with AIDSThe role of pharmaceutical agents in appetite stimulation in patients with end-stage renal diseaseGlutamine deficiency as a cause of human immunodeficiency virus wastingGastroenterological Problems of HIV Infection and AIDSThe Bristol-Myers Anorexia/Cachexia Recovery Instrument (BACRI): a brief assessment of patients' subjective response to treatment for anorexia/cachexiaNutrition and HIV infectionNUTRITIONAL ASPECTS OF HIV INFECTIONManagement of anorexic patients in radiotherapy: A prospective randomized comparison of megestrol and prednisoloneDrug Information Analysis ServiceAnorexiaInteractions Between Nutrition and Infection with Human Immunodeficiency VirusTreatment of Anorexia With Megestrol AcetateRelevance of quality of life assessment to the evaluation of combined-modality therapyAspects métaboliques de la dénutrition au cours de la maladie VIHHormonal and Metabolic Abnormalities in the Malnourished Cancer Patient: Effects on Host-Tumor InteractionNutrition in Advanced Cancer: Anorexia as an Outcome Variable and Target of TherapyMetabolic Disturbances and Wasting in the Acquired Immunodeficiency SyndromeMegestrol Acetate Vs Cyproheptadine in the Treatment of Weight Loss Associated with HIV InfectionThe Microepidemiology of Wasting Syndrome, a Common Link to Diarrheal Disease, Cancer, Rabies, Animal Models of AIDS, and HIV-AIDS (HAIDS).Megestrol acetate in cancer anorexia and weight lossNutritional Effects and Support in the Patient with Acquired Immunodeficiency Syndrome ,Resting energy expenditure, caloric intake, and short-term weight change in human immunodeficiency virus infection and the acquired immunodeficiency syndromeDiabetes Mellitus Induced by Megestrol Acetate in a Patient with AIDS and CachexiaKeith Henry, MD, Scott Rathgaber, MD, Christopher Sullivan, MD, Kathleen McCabe, RNA phase I/II study of high-dose megestrol acetate in the treatment of metastatic breast cancerEnteral alimentation and repletion of body cell mass in malnourished patients with acquired immunodeficiency syndromeMalnutrition in Patients with AIDSA controlled trial of megestrol acetate on appetite, caloric intake, nutritional status, and other symptoms in patients with advanced cancerAnorexia and Cachexia: An UpdateReview article: treatment of the gastrointestinal manifestations of AIDSAIDS: an overviewThe use of drugs in patients with gastrointestinal manifestations of AIDSMechanical Ventilation for Pneumocystis carinii Pneumonia in AIDS"Pilot" StudiesJohn E. Nelson, MD, PhDMegestrol Acetate and HyperpneaW. Jeffrey Fessel, MDMegestrol Acetate and Cachexia Associated with Human Immunodeficiency Virus (HIV) InfectionPriscilla A. Furth, MDMegestrol acetate: clinical experienceTreatment of AIDS Anorexia-Cachexia Syndrome and LipodystrophyTreatment of Cachexia in the Elderly 15 November 1988Volume 109, Issue 10Page: 840-841KeywordsBreast cancerHIVHIV infectionsImmunityInterleukinsMalnutritionNutritionProgesteroneWeight gain ePublished: 1 December 2008 Issue Published: 15 November 1988 PDF downloadLoading ...