tbuckley/cabot-search huggingface dataset:
Impact of aboriginal ethnicity on HCV core-induced IL-10 synthesis: Interaction with IL-10 gene polymorphisms
Authors: Koko Bate Aborsangaya, Iga Dembinski, Suresh Khatkar, Martin Prince Alphonse, Peter Nickerson, Julia D. Rempel
Journal: Hepatology (2007)

Abstract The host immune response is a critical determinant in viral infection outcome. Epidemiological studies indicate that North American indigenous peoples are more resistant to chronic HCV infection than other populations. Due to the prominence of IL-10 in chronic HCV infection, we investigated the genetic tendency to produce IL-10 in Caucasian (CA) and First Nation (FN) populations. Peripheral blood mononuclear cells (PBMCs) from CA subjects had a greater tendency to produce IL-10 defined by allelic polymorphisms, as well as genotypes and haplotypes, at the -1082, -819, and -592 positions of the IL-10 promoter. More importantly, we directly evaluated the influence of ethnicity on the ability of HCV core protein to induce IL-10 synthesis and found significantly higher IL-10 production by PBMCs isolated from healthy CA subjects compared with FN subjects. Further examination of the underlying relationship between core-induced IL-10 with the high, intermediate, and low phenotypes at the -1082, -819, and -592 position revealed that spontaneous and core-induced IL-10 synthesis tended to interact negatively with defined polymorphisms. This was particularly evident for the FN cohort, in which the relationship was strengthened by a stronger interaction of core with the low–IL-10–producing phenotypes. As with previous studies, concanavalin A induced IL-10 synthesis from the CA cohort positively associated with defined genetic phenotypes. Conclusion : Cells from FN subjects had a reduced capacity to produce IL-10 in response to HCV core protein, suggesting that reduced susceptibility of FN immunity to virally induced IL-10 synthesis might contribute to epidemiological observations of enhanced HCV clearance. (Hepatology 2007;45:623–630.)
Deletion of the background potassium channel TREK-1 results in a depression-resistant phenotype
Authors: Catherine Heurteaux, Guillaume Lucas, Nicolas Guy, Malika El Yacoubi, Susanne Thümmler, Xiao-Dong Peng, Florence Noble, Nicolas Blondeau, Catherine Widmann, Marc Borsotto, Gabriella Gobbi, Jean-Marie Vaugeois, Guy Debonnel, Michel Lazdunski
Journal: Nature Neuroscience (2006)
COX-2 Up-regulation and vascular smooth muscle contractile hyperreactivity in spontaneous diabetic / mice
Authors: Z GUO, W SU, S ALLEN, H PANG, A DAUGHERTY, E SMART, M GONG
Journal: Cardiovascular Research (2005)

Abnormalities in vascular constriction and dilatation are associated with early diabetes and contribute to diabetic vascular complications. However, mechanisms underlying such vascular dysfunction remain to be fully elucidated. The current study tests the role of cyclooxygenase-2 (COX-2) in diabetic vascular smooth muscle dysfunction.Small mesenteric artery and aorta are isolated from type 2 diabetic db/db and control mice. Isometric contractions in response to serotonin, angiotensin II, phenylephrine and high potassium are determined in small spiral mesenteric arterial or aortic strips. COX-2 mRNA and protein levels are analyzed by using DNA microarray, real-time PCR and immunoblot.Contractions induced by serotonin, angiotensin II, phenylephrine and high potassium are significantly higher in endothelium-denuded smooth muscle strips isolated from db/db mice than in those isolated from control mice. The contractile hyperreactivity is observed in aortic and third-order branch small mesenteric arterial smooth muscle strips. DNA microarray, real-time PCR and immunoblot analysis show that compared with control mice, COX-2 mRNA and protein are significantly increased in db/db mice aortic smooth muscle. The COX-2 up-regulation is temporally associated with the development of diabetes mellitus and vascular smooth muscle contractile hyperreactivity. Inhibition of COX-2 with NS-398 or SC-58125 partially--but significantly--alleviates agonist-induced but not potassium-induced contractile hyperreactivity. In addition, serum isolated from db/db mice induces COX-2 expression and increases thromboxane A2 production in primary cultured vascular smooth muscle cells (VSMC). SQ-29548, a TP receptor antagonist, diminished the db/db mice vascular smooth muscle contractile hyperreactivity.COX-2 is up-regulated and contributes at least in part to the vascular smooth muscle contractile hyperreactivity in db/db mice.
POPTREEW: Web Version of POPTREE for Constructing Population Trees from Allele Frequency Data and Computing Some Other Quantities
Authors: Naoko Takezaki, Masatoshi Nei, Koichiro Tamura
Journal: Molecular Biology and Evolution (2014)

POPTREE software, including the command line (POPTREE) and the Windows (POPTREE2) versions, is available to perform evolutionary analyses of allele frequency data, computing distance measures for constructing population trees and average heterozygosity (H) (measure of genetic diversity within populations) and GST (measure of genetic differentiation among subdivided populations). We have now developed a web version POPTREEW (http://www.med.kagawa-u.ac.jp/∼genomelb/takezaki/poptreew/) to provide cross-platform access to all POPTREE functions including interactive tree editing. Furthermore, new POPTREE software (POPTREE, POPTREE2, and POPTREEW) computes standardized GST and Jost's D, which may be appropriate for data with high variability, and accepts genotype data in GENEPOP format as an input.
ENHANCED EXTERNAL COUNTERPULSATION REDUCES VASCULAR INFLAMMATION PROMOTED BY HYPERCHOLESTEROLEMIA
Authors: William E. Lawson, Yan Zhang, Xiaohong He, Donghong Liu, Guifu Wu, Yan Zhang, Xiaolin Chen, Hong Ma, Zhimin Du, Yugang Dong, Yafei Jin, Wen He, Kuijian Wang, John CK Hui, Zhensheng Zheng
Journal: Journal of the American College of Cardiology (2010)
Adrenocortical function: An indicator of severity of disease and survival in chronic critically ill patients
Authors: L. F. R. Span, A. R. M. M. Hermus, A. K. M. Bartelink, A. J. Hoitsma, J. S. F. Gimbrère, A. G. H. Smals, P. W. C. Kloppenborg
Journal: Intensive Care Medicine (1992)
Arm and Leg Blood Pressures
Authors: Charles A. Bertrand
Journal: JAMA (1974)

ABSTRACT To the Editor.— The recent article on ultrasound measurement of arm and leg blood pressures by Felix et al (226:1096, 1973) surprised us. The controversy mentioned needs a bibliographic comment.To quote from the report:Workers with the Korotkoff method report marked elevations of systolic leg pressures over arm pressures in normal adults and in children. Interpretation of these studies is complicated by varying approaches to the problem of cuff size. Pascarelli and Bertrand compared arm and leg pressures measured by intra-arterial catheter and concluded that the two are substantially identical. Park and Gunterorth reported similar findings with direct measurements in children. Hamilton et al, however, measured intra-arterial pressures in the femoral and axillary arteries and concluded that the supine blood pressure in the leg ranges from 10 to 40 mm Hg higher than in the arm. Finally, Kotte and associates used both direct and indirect methods and found evidence
"ALLERGY AND THE ACID BASE BALANCE"
Authors: R. H. Kampmeier
Journal: JAMA (1931)

<h3>To the Editor:</h3> —I have read with interest the article by Dr. Beckman on "Allergy and the Acid-Base Balance" (The Journal, November 22). My fairly extensive experience, especially in the Great Lakes basin and to a lesser extent in Colorado, has borne out some of his observations. However, one statement bears questioning: "That nearly all allergic persons are free from attacks at altitudes of 4,000 feet or more is an established fact, usually explained by the relative freedom of the air from offending pollens; but how shall one explain the equal degree of relief obtained by individuals whose malady is not pollen caused...?" The local altitude is 4,600 feet, and numerous patients are seen from districts to altitudes of which are as high as 8,000 feet and over. With respect to hay-fever, it may interest the author of the article in question to know that Russian thistle and several lesser
Treatment of Malaria in the United States
Authors: Kevin S. Griffith, Linda S. Lewis, Sonja Mali, Monica E. Parise
Journal: JAMA (2007)

has been eliminated from the United States, it remains a leading infectious disease worldwide.As a consequence, every year in the United States an average 1200 cases of malaria are reported, almost all imported, resulting in up to 13 deaths per year. 1 The unfamiliarity of US clinicians and laboratory personnel with malaria and drug resistance patterns has contributed to delays in diagnosis and treatment, at times with adverse outcomes. 2o address this problem, we provide clinicians with practical recommendations for the diagnosis and treatment of malaria in the United States, based on published evidence; the Centers for Disease Control and Prevention (CDC) experience in assisting US clinicians; and the available drugs and diagnostic modalities used in this country. METHODSWe performed a systematic MEDLINE search from 1966 to 2006 using the search term malaria (with the subheadings congenital, diagnosis, drug therapy, epidemiology, and therapy).This search was conducted on August 1, 2006, and resulted in 5588 potentially relevant articles.We reviewed titles and/or abstracts of all articles to determine rel-evance to this article, hand searched bibliographies of pertinent articles, and reviewed articles suggested by experts in the treatment of malaria in North America.Recommendations are based on randomized controlled trials, observational studies, and consensus expert opinion.
Comparative Effectiveness of Exercise Testing and Continuous Monitoring for Detecting Arrhythmias in Patients with Previous Myocardial Infarction
Authors: MICHAEL CRAWFORD, ROBERT A. O'ROURKE, NALLAN RAMAKRISHNA, HARTMUT HENNING, JOHN ROSS
Journal: Circulation (1974)

To detect unsuspected arrhythmias, 60 patients with previous myocardial infarction were studied by both submaximal treadmill exercise testing and 10 hours of continuous ECG monitoring (Holter technique) during normal activity. Significant arrhythmias were detected in 28 of 60 patients (47%). Eight patients (13%) had one or more premature ventricular contractions on their resting ECG and all had significant arrhythmias detected by exercise and/or Holter monitoring. Eighteen patients (30%) had frequent ectopic beats during or within 15 minutes after treadmill exercise and 22 patients (37%) had significant arrhythmias during continuous ECG monitoring. In 10 patients (17%) continuous ECG monitoring detected significant arrhythmias when exercise did not, while in six instances (10%) frequent premature ventricular beats were present with exercise but not during Holter monitoring. In four of 12 patients in whom both tests were positive, continuous ECG monitoring detected ventricular tachycardia when exercise showed only isolated ectopic ventricular beats. Fourteen patients (23%) had major arrhythmias detected by ECG monitoring; only six of the 14 were also detected by exercise testing. We conclude that both treadmill exercise and continuous ECG monitoring are useful for arrhythmia detection in post myocardial infarction patients but that continuous ECG monitoring often discloses different and more serious arrhythmias than treadmill exercise.
Mesothelioma and Its Association With Asbestosis
Authors: Maxwell Borow
Journal: JAMA (1967)

Within a three-year period in a community hospital, 17 cases of mesothelioma, nine of the pleura and eight of the peritoneum, were found at surgery. Two of our patients contracted this malignancy with only environmental exposure consisting of living in a community adjacent to the asbestos mill. In the same hospital, there has been a high incidence of bronchogenic carcinoma with asbestosis. A review of the autopsy material of the past decade brought to light only one additional case. It is our belief that the incidence of mesothelioma is increasing as is the incidence of asbestosis, with the increasing application of this product in many different industries.
Polycythaemia and Vitamin C
Authors: J. Deeny
Journal: BMJ (1940)

A review of all available cervical smears from 96 women who subsequently developed invasive cervical carcinoma was undertaken. The aim of the study was to determine the incidence of confirmed negative smears prior to the histologic diagnosis of carcinoma and investigate the relationship between the duration and grade of smear abnormality, the patients9 age and the histologic types of cervical carcinoma. The results indicate that only 10% of women had confirmed negative smears, the majority occurring more than 7 years before the diagnosis of carcinoma. In contrast, 89% of young women (under 40 years of age) had a significant abnormality (moderate dyskaryosis or worse) up to 6 years before diagnosis. There is evidence to suggest that the preinvasive phase of cervical carcinoma may be shorter in younger women and that the less common types of cervical carcinoma occur more frequently in this group. The combination of inadequate clinical follow up and false negative cytology may have allowed a significant proportion of these women to develop invasive cervical carcinoma. Possible reasons for false negative smears have been identified and methods aimed at decreasing their frequency are discussed.
Incidence, Predictors, and Prognostic Impact of Late Bleeding Complications After Transcatheter Aortic Valve Replacement
Authors: Philippe Généreux, David J Cohen, Michael Mack, Josep Rodes-Cabau, Mayank Yadav, Ke Xu, Rupa Parvataneni, Rebecca Hahn, Susheel K Kodali, John G Webb, Martin B Leon
Journal: Journal of the American College of Cardiology (2014)
A METHOD OF LOCALIZING POINTS IN THE HEMISPHERICAL GANGLIA.Read in the Section of Neurology and Medical Jurisprudence, at the Forty-fourth Annual Meeting of the American Medical Association.
Authors: WILLIAM FULLER
Journal: JAMA (1893)

I will present to the Section the result of my work in the line of the subject given which I think is of value, since it enables one easily and expeditiously to locate any part of the surface or internal structure definitely, and with a precision that can be arrived at in no other way. I have hardened a brain with great care so as to maintain the natural shape as nearly as possible. The lateral halves were separated in the median line and each embedded in tallow, taking care to place each half in the same positions in the boxes surrounding them. Each half was carefully sliced by a gauge so that the slices were three-sixteenths of an inch thick and perpendicular to a line in the long axis of the brain, which was seven inches in length, making thus thirty-seven slices of each ganglion. The right, ganglion was
Controlled Trial of Phetharbital, a Non-hypnotic Barbiturate, in Unconjugated Hyperbilirubinaemia
Authors: J. Hunter, R. P. H. Thompson, M. O. Rake, R. Williams
Journal: BMJ (1971)

Eleven patients with mild unconjugated hyperbilirubinaemia (Gilbert9s syndrome) took part in a double-blind cross-over trial of phenobarbitone and phetharbital, a non-hypnotic barbiturate. Significant reductions in plasma bilirubin were observed with both drugs, but six patients complained of sleepiness on phenobarbitone, and phetharbital was preferred by most patients. Phetharbital was also effective in the rare severe unconjugated hyperbilirubinaemia of the Crigler-Najjar syndrome (Type 2). Symptoms attributed to Gilbert9s syndrome, including nausea and abdominal pain, were less consistently relieved.
Inactivation of Hepatitis B Virus Replication in Cultured Cells and In Vivo with Engineered Transcription Activator-Like Effector Nucleases
Authors: Kristie Bloom, Abdullah Ely, Claudio Mussolino, Toni Cathomen, Patrick Arbuthnot
Journal: Molecular Therapy (2013)

Chronic hepatitis B virus (HBV) infection remains an important global health problem. Stability of the episomal covalently closed circular HBV DNA (cccDNA) is largely responsible for the modest curative efficacy of available therapy. Since licensed anti-HBV drugs have a post-transcriptional mechanism of action, disabling cccDNA is potentially of therapeutic benefit. To develop this approach, we engineered mutagenic transcription activator-like effector nucleases (TALENs) that target four HBV-specific sites within the viral genome. TALENs with cognate sequences in the S or C open-reading frames (ORFs) efficiently disrupted sequences at the intended sites and suppressed markers of viral replication. Following triple transfection of cultured HepG2.2.15 cells under mildly hypothermic conditions, the S TALEN caused targeted mutation in ~35% of cccDNA molecules. Markers of viral replication were also inhibited in vivo in a murine hydrodynamic injection model of HBV replication. HBV target sites within S and C ORFs of the injected HBV DNA were mutated without evidence of toxicity. These findings are the first to demonstrate a targeted nuclease-mediated disruption of HBV cccDNA. Efficacy in vivo also indicates that these engineered nucleases have potential for use in treatment of chronic HBV infection.
THE EFFECT OF KHELLIN ON CARDIO-PULMONARY FUNCTION IN CHRONIC PULMONARY DISEASE 12
Authors: E. N. Silber, G. L. Snider, H. Goldberg, L. N. Katz, D. B. Radner
Journal: Journal of Clinical Investigation (1951)

Extract from the fruit of the plant, Ammi Vis- naga Lamn, has long been employed by inhabitants of the Middle East for relief of renal colic.The major biologically active component, khellin, was isolated in impure form by Fantl and Salem in 1930 (1).The chemical structure of khellin (vis- ammin) was established by Spath and Gruber (2), and the pharmacology of this compound was in- vestigated by several groups in Egypt, chief among them being Samaan (3) and Anrep, Barsoum, and Kenawy (4).These investigators have re- ported that khellin exhibits marked coronary dilator, bronchodilator and antispasmodic activity.Reports of beneficial results from its use in angina pectoris (5, 6) and in bronchial asthma (7) prompted the Cardiovascular Department of this institution to investigate the effect of khellin in these diseases and in chronic cor pulmonale.The results of these studies have been previously re- ported elsewhere (8).In that study eight patients, clinically judged to have chronic cor pulmonale, were included.This group was characterized by pulmonary disease, diminished vital capacity, and in some instances, clubbing of the fingers and cy- anosis.Four of the patients were in congestive heart failure.In all eight patients, khellin therapy resulted in improvement characterized by amelioration of dyspnea and wheezing, decreased cyanosis, increase in exercise capacity and an increased sense of well being.In order to delineate the mechanism responsible for the improvement noted in these patients, and to apply objective physiological criteria to such
Long Term Follow-up of Patients Requiring Injectable Epinephrine Following Completion of Oral Immunotherapy for IgE-Cow's Milk Allergy
Authors: Arnon Elizur, Michael R. Goldberg, Michael B. Levy, Liat Nachshon, Moshe Appel, Yitzhak Katz
Journal: Journal of Allergy and Clinical Immunology (2015)
Multiple autoantigen binding capabilities of mouse monoclonal antibodies selected for rheumatoid factor activity.
Authors: R L Rubin, R S Balderas, E M Tan, F J Dixon, A N Theofilopoulos
Journal: The Journal of Experimental Medicine (1984)

We report that approximately 1/4 of monoclonal rheumatoid factors produced by hybridomas derived from fusions of spleen cells from MRL/lpr/lpr mice with systemic lupus erythematosus (SLE) and arthritis exhibited multiple reactivities with other autoantigens, including dDNA , histones, and/or cytoskeletal-cytoplasmic elements. The patterns of reactivities of most of these clones differed, indicating that each had a separate B cell ancestor. Studies with eluted antibodies demonstrated that a single species of antibody molecules was responsible for the observed multiple reactivities. Inhibition experiments suggested that an antibody combining site may be large enough to accommodate dissimilar epitopes. These findings may provide further insights into the generation and extent of antibody diversity as well as the etiopathogenesis of systemic autoimmune diseases.
EML4–ALK Fusions: Propelling Cancer but Creating Exploitable Chaperone Dependence
Authors: Paul Workman, Rob van Montfort
Journal: Cancer Discovery (2014)

Abstract Summary: The crystal structure of a conserved tubulin-binding region of the EML1 protein reveals a highly atypical fold in one of its β-propeller domains. Disruption of the EML1 core region domain in many of the oncogenic EML4–ALK fusion protein variants that drive non–small cell lung cancer explains their dependence on the HSP90 molecular chaperone, provides a basis to allow more precise patient stratification for therapy, and suggests a more general model for other oncogenic fusion proteins. Cancer Discov; 4(6); 642–5. ©2014 AACR.
A Novel Synbiotic Concept Derived From Cow's Milk-free Source Materials Beneficially Affects In Vivo Immune Responses In Murine Models For Influenza Vaccination And Cow'S Milk Allergy
Authors: B.C.A.M. van Esch, J.E. Langford, B. van't Land, A. Boelrijk, J. Garssen, L.M.J. Knippels, A.P. Vos
Journal: Journal of Allergy and Clinical Immunology (2012)
WHERE THE WEAK-LUNGED OR CONSUMPTIVE AND NEURASTHENIC MAY LIVE AND ENJOY LIFE.
Authors: W. S. WATSON
Journal: JAMA (1898)

<h3>OBSERVATIONS.</h3> My object in writing this paper is to call attention to conditions, localities and influences that are beneficial to certain classes of sufferers, basing my conclusions upon my own observations and the statistics and observations of others. It is impossible for all men to be rated by one general rule, nor will one climate suit all conditions. There is a distinctive individuality that does not allow a fixed or arbitrary procedure, men differ in their constitutions, temperaments, likes, dislikes and necessities as they do in their faces and forms. A climate favorable to long life is the one thing sought by man. The question is, where can I go to prolong my chances of life, suffer least and get the most enjoyment out of the time allotted me? Thousands are asking these questions, the consumptive perhaps more than any other, since consumption is the greatest scourge of the human
A thermophysiological rationale for endurance training for racquet games
Authors: P. A. Hancock
Journal: British Journal of Sports Medicine (1981)

Three male athletes performed incremental work: Basal Metabolic Rate (BMR), 100 W and 150 W in two levels of controlled environmental heat. Conditions inside an environmental chamber were preset at 25°C 40% RH and 30°C 50% RH being 22°C and 29°C on the Effective Temperature Scale. Expired air and six body temperatures—two invasive and four skin sites—were monitored. Core and mean body temperatures, calculated from these figures, correlated highly with expired air values for all the anthropometrically homogeneous group. Results were in agreement with unpublished data of Bundgaard, i.e. the higher the V̇O 2 max of the subject the smaller the range of expired air values and the smaller the increase in both mean and core body temperature during heat stress. Such thermophysiological reaction helps the athlete to prevent the onset of mild hyperthermia and the accompanying fatigue, independent of mitigating behavioural support. The intermittent bursts of heavy physical activity required of the racquet athlete argue for a similar cardio-vascular training regimen. Data from this study suggest that such athletes would be wise to augment training schedules with prolonged cardio-vascular endurance work especially when the possibility of competing in high ambient temperature is foreseen.