Sumatriptan-Associated Mesenteric Ischemia
Authors: Julia J. Liu, David J. Brandhagen, Joseph C. Ardolf
Journal: Annals of Internal Medicine (2000)

Letters4 April 2000Sumatriptan-Associated Mesenteric IschemiaJulia J. Liu, MD, David J. Brandhagen, MD, and Joseph C. Ardolf, MDJulia J. Liu, MDMayo Clinic and Foundation; Rochester, MN 55905 (Liu)Mayo Clinic and Foundation; Rochester, MN 55905 (Brandhagen)Abbott Northwestern Hospital; Minneapolis, MN (Ardolf), David J. Brandhagen, MDMayo Clinic and Foundation; Rochester, MN 55905 (Liu)Mayo Clinic and Foundation; Rochester, MN 55905 (Brandhagen)Abbott Northwestern Hospital; Minneapolis, MN (Ardolf), and Joseph C. Ardolf, MDMayo Clinic and Foundation; Rochester, MN 55905 (Liu)Mayo Clinic and Foundation; Rochester, MN 55905 (Brandhagen)Abbott Northwestern Hospital; Minneapolis, MN (Ardolf)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-7-200004040-00029 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Sumatriptan is a selective 5-hydroxytryptamine agonist with potent vasoconstrictor properties that is widely prescribed for the treatment of migraine. Myocardial infarction due to coronary vasospasm has been reported (1). A recent report described eight cases of ischemic colitis temporally associated with sumatriptan use, but important details were not available for many of these cases (2).We describe two well-characterized cases of mesenteric ischemia associated with sumatriptan use. The first patient was a 45-year-old woman who had migraine (without aura) and chronic daily headache; she was referred for evaluation of four episodes of abdominal pain and bloody diarrhea. ...References1. Main ML, Ramaswamy K, Andrews TC. Cardiac arrest and myocardial infarction immediately after sumatriptan injection [Letter]. Ann Intern Med. 1998;128:874. LinkGoogle Scholar2. Knudsen J, Friedman B, Chen M, Goldwasser J. Ischemic colitis and sumatriptan use. Arch Intern Med. 1998;158:1946-8. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Mayo Clinic and Foundation; Rochester, MN 55905 (Liu)Mayo Clinic and Foundation; Rochester, MN 55905 (Brandhagen)Abbott Northwestern Hospital; Minneapolis, MN (Ardolf) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByReview article: the pharmacological causes of colon ischaemiaTriptansMesenteric IschemiaIschémie mésentérique étendue associée à la prise excessive de naratriptan et de jus de pamplemousseTreatment Choices and Patterns in Migraine Patients With and Without a Cardiovascular Risk ProfileMesenteric Ischemia: Still a Deadly Puzzle for the Medical CommunityThe TriptansTriptansColonic Ischemia Associated With Naratriptan UsePharmacologic Characterization of Contractile Serotonergic Receptors in Human Isolated Mesenteric ArteryDrugs acting on the cerebral and peripheral circulationsSumatriptan 4 April 2000Volume 132, Issue 7Page: 597KeywordsAbdominal painAngiographyColectomyColitisDiarrheaHypotensionIschemiaMigraineMyocardial infarctionNecrosis Issue Published: 4 April 2000 CopyrightCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...