tbuckley/cabot-search huggingface dataset:
Abstract 3254: Cadherin-11 function is required for full neoplastic transformation by v-Src
Authors: Leda Raptis, Mulu Geletu, Rozanne Arulanandam
Journal: Cancer Research (2012)

Abstract The signal transducer and activator of transcription-3 (Stat3) has emerged as an important signal transducer with a role in cancer etiology. Following activation of a number of growth factor or cytokine receptors or expression of oncogenes such as vSrc, Stat3 is phosphorylated at tyr-705, dimerizes and migrates to the nucleus where it activates transcription from a number of genes involved in cell division and survival. We recently discovered a novel pathway of activation of Stat3, triggered by cadherin engagement. Stat3 activation was caused by a striking upregulation of the Rac GTPase and IL6, and induced downregulation of the p53 antioncogene, upregulation of anti-apoptotic genes and a potent survival signal. A large number of oncogenes such as vSrc activate the E2F transcription factor, found to be hyperactive in many cancers. E2F induces the expression of genes involved in cell division, as well as a number of receptor tyrosine kinases, that can, in turn, activate Stat3. However, at the same time E2F is a potent apoptosis inducer, hence the high demand of transformed cells for survival signals. Since cadherin engagement activates Stat3, a potent survival signal, we examined the effect of downregulation of cadherin-11 upon transformation of mouse Balb/c3T3 fibroblasts by vSrc. Cadherin-11 knockdown through shRNA expression with a retroviral vector caused a dramatic reduction in Stat3 activity. At the same time, expression of vSrc in cadherin-11 knockdown cells failed to cause transformation; in the contrary, vSrc expression induced apoptosis. These data indicate that cadherin-11 is necessary for full neoplastic transformation of mouse fibroblasts by vSrc. This is especially remarkable because Src has been shown to have a negative effect upon, although not eliminate cadherin function, since Stat3 activity was, in fact increased in vSrc-expressing cells upon cadherin engagement. Therefore, it appears that the residual amounts of cadherin-11 present are sufficient to activate Stat3 and prevent apoptosis induced by the Src/E2F axis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3254. doi:1538-7445.AM2012-3254
Short 5Fr vs Long 3Fr Pancreatic Stents in Patients at Risk for Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis
Authors: Prabhleen Chahal, Paul R. Tarnasky, Bret T. Petersen, Mark D. Topazian, Michael J. Levy, Christopher J. Gostout, Todd H. Baron
Journal: Clinical Gastroenterology and Hepatology (2009)
CONTRIBUTION OF FETAL/MATERNAL INCOMPATIBILITY TO ÆTIOLOGY OF PRE-ECLAMPTIC TOXÆMIA
Authors: AlanC. Stevenson, B.C. Clare Davison, Burhan Say, Sedat Ustuoplu, Durmus Liya, M. Abul-Einen, H.K. Toppozada
Journal: The Lancet (1971)
Use of a Constitutively Active Hypoxia-Inducible Factor-1α Transgene as a Therapeutic Strategy in No-Option Critical Limb Ischemia Patients
Authors: Sanjay Rajagopalan, Jeffrey Olin, Steven Deitcher, Ann Pieczek, John Laird, P. Michael Grossman, Corey K. Goldman, Kevin McEllin, Ralph Kelly, Nicolas Chronos
Journal: Circulation (2007)

Background— Critical limb ischemia, a manifestation of severe peripheral atherosclerosis and compromised lower-extremity blood flow, results in a high rate of limb loss. We hypothesized that adenoviral delivery of a constitutively active form of the transcription factor hypoxia-inducible factor-1α (ie, Ad2/HIF-1α/VP16 or HIF-1α) into the lower extremity of patients with critical limb ischemia would be safe and might result in a durable clinical response. Methods and Results— This phase I dose-escalation program included 2 studies: a randomized, double-blind, placebo-controlled study and an open-label extension study. In total, 34 no-option patients with critical limb ischemia received HIF-1α at doses of 1×10 8 to 2×10 11 viral particles. No serious adverse events were attributable to study treatment. Five deaths occurred: 3 in HIF-1α and 2 in placebo patients. In the first (randomized) study, 7 of 21 HIF-1α patients met treatment failure criteria and had major amputations. Three of the 7 placebo patients rolled over to receive HIF-1α in the extension study. No amputations occurred in the 2 highest-dose groups of Ad2/HIF-1α/VP16 (1×10 11 and 2×10 11 viral particles). The most common adverse events included peripheral edema, disease progression, and peripheral ischemia. At 1 year, limb status observations in HIF-1α patients included complete rest pain resolution in 14 of 32 patients and complete ulcer healing in 5 of 18 patients. Conclusions— HIF-1α therapy in patients with critical limb ischemia was well tolerated, supporting further, larger, randomized efficacy trials.
NHS takes makers of generic drugs to court for price fixing
Authors: Owen Dyer
Journal: BMJ (2004)

The NHS is seeking over £100m ($183m; €150m) in compensation from two manufacturers of generic drugs that allegedly formed a cartel to fix artificially high prices for ranitidine, the generic form of the ulcer drug Zantac.

The case is the latest to emerge from an ongoing investigation by the NHS Counter Fraud and Security Management Service into anticompetitive behaviour in the generic drug industry. Jim Gee, chief executive of the service, said the overcharging for ranitidine was the most serious example yet uncovered and may have deprived the NHS of up …
Infantile Hypercalcaemia with Keratopathy and Sodium Depletion
Authors: A. C. Kendall
Journal: BMJ (1957)

Thirteen dogs with postanesthetic esophageal dysfunction were identified; 10 of these animals had esophageal stricture. Regurgitation was noted in six dogs during the inciting anesthetic event. Clinical problems common to all dogs included vomiting/regurgitation and weight loss. Coughing was noted in six dogs, and aspiration pneumonia was present in four of these dogs. The associated mortality rate was 23%. The duration of symptoms ranged from 17 to 150 days, and the diagnosis was often delayed (up to 76 days from onset of clinical signs to diagnosis). Postanesthetic esophageal dysfunction was a debilitating and costly problem that developed in one dog despite current preventative treatment.
Older women who take adjuvant treatment after lumpectomy may not need radiotherapy
Authors: David Spurgeon
Journal: BMJ (2004)

Results of two studies of breast cancer reported in the New England Journal of Medicine last week have prompted the authors of an accompanying editorial to propose that lumpectomy plus tamoxifen but without local irradiation “is a realistic choice” for some women over the age of 70 years.

A re-evaluation of the need for radiotherapy has been made against a changed background since earlier trials, says the editorial. These changes include improved imaging and techniques for locating tumours and the widespread use of adjuvant therapy with drugs such as tamoxifen, which reduces the risk of local recurrence and improves survival.

The first new trial compared local radiotherapy plus tamoxifen with tamoxifen alone in women …
Hormone replacement therapy and patterns of osteoarthritis: baseline data from the Ulm Osteoarthritis Study
Authors: A. Erb
Journal: Annals of the Rheumatic Diseases (2000)

<h3>OBJECTIVES</h3> It has been suggested that hormone replacement therapy (HRT) may protect against osteoarthritis (OA). The aim of this paper was to assess the association between HRT and radiographically defined patterns of OA. <h3>METHODS</h3> 475 consecutive women aged 50 years or older (mean age 66.1) who underwent hip or knee joint replacement because of advanced OA in four hospitals in south west Germany were enrolled in a cross sectional study. Participants underwent a standardised interview including detailed history of medication use and a physical examination. Furthermore, radiographs of the joint being replaced and of the contralateral joint as well as of both hands were obtained. Patients were categorised as having bilateral or unilateral OA according to the presence or absence of radiographic OA in the contralateral joint. If radiographic OA of different hand and finger joint groups was present, participants were categorised as having generalised OA (GOA). Logistic regression was used to estimate odds ratios and their 95% confidence intervals for the association between HRT and bilateral or GOA while adjusting for potential confounders. <h3>RESULTS</h3> Fifty five women (11.6%) were using HRT. The median duration of use was 5.4 years. The prevalence of bilateral and GOA was similar among users of ORT (86.3% and 27.5%, respectively) and among non-users of HRT (88.7% and 35.7%, respectively). After adjustment for potential confounding factors, the odds ratios (95% confidence intervals) of bilateral OA and GOA among HRT users compared with non-users was 1.21 (0.48, 3.03) and 1.21 (0.53, 2.74), respectively. <h3>CONCLUSION</h3> Despite limited generalisability because of the selective study sample, these data do not support the hypothesis that HRT acts as a systemic protective factor against OA.
Effect of orally administered beclomethasone dipropionate on calcium absorption from the gut in normal subjects.
Authors: B J Smith, P J Phillips, P R Pannall, H J Cain, W J Leckie
Journal: Thorax (1993)

BACKGROUND--There is evidence that patients with chronic obstructive airways disease and asthma who take inhaled steroids have a low bone density. As most of a drug given from a metered dose inhaler is actually swallowed, the possibility that swallowed beclomethasone dipropionate acts topically in the gut to impair calcium absorption was investigated. Such an effect, if sustained, may be a causative factor of long term bone loss. METHODS--A two week randomised, double blind, placebo controlled, crossover trial was performed in 12 normal volunteers. Subjects were randomly allocated to swallow beclomethasone dipropionate capsules (500 micrograms twice a day) or placebo for one week. The alternate capsule was given throughout the second week. At the end of each week, calcium absorption was assessed by a strontium absorption test. Serum parathyroid hormone, plasma calcium, and plasma phosphate concentrations were determined on the last two days of each week. Twenty four hour urinary calcium, hydroxyproline, and cortisol concentrations were measured for four successive days in each week. RESULTS--All subjects completed the study. There was a 12% reduction in strontium absorption during the beclomethasone dipropionate ingestion week. There was also a 23% reduction in 24 hour urinary cortisol excretion during the same week. CONCLUSIONS--Calcium absorption (measured by a strontium absorption test) was reduced by oral administration of beclomethasone dipropionate for one week. Decreased calcium absorption due to swallowed corticosteroid may contribute to side effects of inhaled steroids and further long term studies are needed.
Indigenous Australians and Living Kidney Donation
Authors: Natasha M. Rogers, Paul D. Lawton, Matthew D. Jose
Journal: New England Journal of Medicine (2009)

To the Editor: Indigenous Australians comprise 2.5% of the total population of Australia, but like other minority groups worldwide, rates of chronic kidney disease are higher among this indigenous group than among the general population. Transplantation remains the preferred form of renal-replacement therapy, and the use of living donors maximizes transplantation rates with a generally minimal long-term effect on donors.1 However, the consequences of the use of this strategy in indigenous Australians are unclear, given the likelihood of a family or community history of chronic kidney disease in potential donors. We performed a retrospective analysis of all living kidney donors . . .
Diseases of the Nose, Throat, Ear, Head, and Neck
Authors: John Bailey Gregg
Journal: JAMA (1991)

During many years as resident physician, private practitioner, and educator in otorhinolaryngology, I have found the textbook by Ballenger to be a frequently used and reliable reference source. The latest—14th—edition updates and expands the treatise begun in 1908 by the editor's great-uncle. Forty-nine authors representing 15 medical schools, research institutions, and private practice have contributed to this edition (15 more than the previous edition). Information pertinent to all facets of modern otolaryngology-head and neck surgery is presented in a style similar to the previous edition, in six sections with 68 chapters. A better format and improved publication techniques, including larger pages and wider spacing between letters and lines (but an essentially unchanged number of words per page), improve clarity of print and promote readability but add a pound of weight to this tome. Reproduction quality of artists' drawings and photographs is generally improved as compared with the 13th edition. Subsections
Glycoprotein IIb/IIIa receptor antagonism in patients with acute coronary syndromes and prior coronary artery bypass grafting: Results from PRISM PLUS
Authors: Stephen J. Servoss, Ying Wan, Steven M. Snapinn, Peter M. DiBattiste, Pierre Theroux, Ik-Kyung Jang, James L. Januzzi
Journal: Journal of the American College of Cardiology (2003)
Inter-Continental American Medical Congress.
Authors: F. B. Brown
Journal: JAMA (1891)

At the regular quarterly meeting of the Golden Belt Medical Society, of Kansas, held in Junction City, Kansas, July 3d, 1891, Dr. W. B. Dewees, President of the Golden Belt, having been appointed a member of the Auxiliary Committee of the Inter Continental American Medical Congress, presented the following resolutions, which were passed unanimously: <i>Resolved</i>, That this society heartily approve of the permanent organization of the Inter-Continental American Medical Congress, believing it to be of material benefit in promoting the interests and welfare of the medical profession of America. <i>Resolved</i>, That the members of this society will do all in their power to promote the interests and welfare of the Congress. <i>Resolved</i>, That the Secretary of this society is hereby instructed to forward a copy of these resolutions to the<i>Kansas Medical Journal</i>andThe Journal of the American Medical Associationfor publication. Secretary Golden Belt Medical Society. Salina, Kansas,
Imported leishmaniasis in the Netherlands from 2005 to 2012: epidemiology, diagnostic techniques and sequence-based species typing from 195 patients
Authors: A Bart, P PAM van Thiel, H JC de Vries, C J Hodiamont, T Van Gool
Journal: Eurosurveillance (2013)

Leishmaniasis is an imported disease in the Netherlands. We report data for the period between 2005 and 2012, on clinical presentation, country where leishmaniasis was acquired, and causative species, for 195 civilian and military patients who had travelled abroad. Most patients were affected by cutaneous leishmaniasis (CL) (n=185 patients), while visceral leishmaniasis (VL) (n=8 patients) and mucocutaneous leishmaniasis (n=2 patients) were less frequently observed. All VL patients had been infected in Europe. CL was mainly acquired in Afghanistan, Surinam, Morocco and Spain. The majority of CL patients consisted of military personnel (55%, 102/185), 78 of whom had been infected during an outbreak in Afghanistan. Parasitological diagnosis was made by a combination of polymerase chain reaction (PCR), microscopy and culture. Compared to a standard of parasitological proof by any method other than the one under consideration, sensitivities of the individual methods ranged from 73% to 98%. Microscopy was least sensitive, but is fast and cheap. Mini-exon repeat PCR combines high sensitivity and specificity, and allows differentiation between species by sequencing of the PCR product. Eight different species or species complexes were identified, allowing species-specific therapy. Four patients proved infected with Leishmania naiffi, a hitherto rarely described cause of leishmaniasis. In comparison to previous decennia, an increase in cutaneous leishmaniasis was observed in our hospital, both in civilian and military patients who had travelled abroad. This calls for increased awareness among clinicians, availability of diagnostic tests and species-specific treatment guidelines in non-endemic countries.
Cytogenetic Abnormalities Predict Clinical Outcome in Non-Hodgkin Lymphoma
Authors: ELLIS G. LEVINE
Journal: Annals of Internal Medicine (1988)

Tumor cytogenetic analysis was done for 68 patients with newly diagnosed non-Hodgkin lymphoma, and recurring cytogenetic abnormalities were correlated with achievement of complete remission, duration of complete remission, and survival. Among all patients, the presence of normal metaphases in tumor material was associated with a higher complete remission rate and longer survival. However, the duration of complete remission did not correlate with the presence or absence of chromosomal changes. Among patients with follicular lymphomas, the presence of normal metaphases in the tumor material was again associated with a higher rate of complete remission and with longer survival. Patients with structural abnormalities of chromosome 17 had a shorter survival than patients without these abnormalities. Among the patients with diffuse large-cell and immunoblastic lymphomas, those with breaks in the short arm of chromosome 2 had a longer survival than those without these breaks. We conclude that chromosomal abnormalities are predictive of clinical outcome in malignant lymphoma.
A multiobserver, population-based analysis of histologic dysplasia in melanocytic nevi
Authors: Michael W. Piepkorn, Raymond L. Barnhill, Lisa A. Cannon-Albright, David E. Elder, David E. Goldgar, Cathryn M. Lewis, John C. Maize, Laurence J. Meyer, Michael S. Rabkin, Richard W. Sagebiel, Mark H. Skolnick, John J. Zone
Journal: Journal of the American Academy of Dermatology (1994)
Challenges in Clinical Nutrition
Authors: JAMES A. HALSTED
Journal: Annals of Internal Medicine (1970)

Editorials1 October 1970Challenges in Clinical NutritionJAMES A. HALSTED, M.D.JAMES A. HALSTED, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-73-4-649 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThirty years ago nutrition was important in clinical medicine. Pellagra, rickets, scurvy, and other diseases known to be caused by primary nutritional deficiencies were not uncommon. However, their eradication was followed closely by the explosion of knowledge in other medical sciences which resulted from government appropriation of large sums for basic research. Coincidentally, the medical profession seemed to lose interest in nutrition. The physician had new masses of knowledge to master. When he did not have to cope with the florid diseases of nutritional deficiency, nutrition easily slipped from his mind. Nutrition training programs found it difficult to attract medical...References1. HODGES R: Personal communication Google Scholar2. OKCUOGLUARCASOYMINNICH AAV: Pica in Turkey. I. The incidence and association with anemia. Amer J Clin Nutr 19:125, 1966 CrossrefMedlineGoogle Scholar3. SANDSTEADPRASADSCHULERT HAA: Human zinc deficiency, endocrine manifestations and response to treatment. Amer J Clin Nutr 20:422, 1967 CrossrefMedlineGoogle Scholar4. SMITHHALSTED JJ: Clay ingestion (geophagia) as a source of zinc for rats. J Nutr. In press, 1970 CrossrefGoogle Scholar5. CROUNSEBOLLETOWENS RAS: Tissue assay of human protein malnutrition using scalp hair. Trans Ass Amer Physicians. In press, 1970 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Research and Development Branch Nutrition Program Department of Health, Education, and Welfare Washington, D. C.*Modified from the Presidential Address, at the Conference on Food Science and Nutritional Diseases in the Middle East. Pahlavi University, Shiraz, Iran, 27 April 1970. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1970Volume 73, Issue 4Page: 649-651KeywordsFoodMalnutritionNutrition Issue Published: 1 October 1970 PDF downloadLoading ...
Drawing the map to implement the 2015 World Anti-Doping Code
Authors: Jiri Dvorak, Richard Budgett, Martial Saugy, Alan Vernec
Journal: British Journal of Sports Medicine (2014)

As of 1 January 2015, the revised 2015 World Anti-Doping Code will be operational in the fight against doping. This will be binding for all stakeholders who unanimously approved the revised code at the ‘World Conference on Doping in Sport’ in Johannesburg, South Africa on 15 November 2013.

Following this, a medical and scientific multidisciplinary consensus meeting on antidoping in sport was held at the home of FIFA, Zurich, Switzerland from 29 to 30 November 2013. The aim was to create a road map to implement …
Group-2 Innate Lymphoid Cells Promote Air-Pollutant Induced Airway Inflammation and Hyperresponsiveness (AHR)
Authors: Qi Yang, Moyar Q. Ge, Blerina Kokalari, Imre G. Redai, Xinxin Wang, Avinash Bhandoola, Angela Haczku
Journal: Journal of Allergy and Clinical Immunology (2014)
IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction
Authors: Claudia A Nold-Petry, Camden Y Lo, Ina Rudloff, Kirstin D Elgass, Suzhao Li, Michael P Gantier, Amelie S Lotz-Havla, Søren W Gersting, Steven X Cho, Jason C Lao, Andrew M Ellisdon, Björn Rotter, Tania Azam, Niamh E Mangan, Fernando J Rossello, James C Whisstock, Philip Bufler, Cecilia Garlanda, Alberto Mantovani, Charles A Dinarello, Marcel F Nold
Journal: Nature Immunology (2015)
Constriction of collateral arteries induced by "head-up tilt" in patients with occlusive arterial disease of the legs
Authors: K AGERSKOV, O HENRIKSEN, K H TONNESEN, N A LASSEN
Journal: Cardiovascular Research (1981)

The effect of head-up tilt on leg blood flow and segmental arterial blood pressures was studied in 21 patients with occlusion or severe stenosis of the common or superficial femoral artery. Arterial pressure was measured directly in the brachial artery, common femoral artery and popliteal artery. Relative change in blood flow in the leg during tilt was estimated by changes in arterio-venous oxygen differences and by the indicator dilution technique in nine patients. Head-up tilt caused a decrease in leg blood flow of 36% corresponding to an increase in total vascular resistance of 57%. Tilt did not change the pressure gradient from femoral to popliteal artery in the patients with occlusion of the superficial femoral artery, indicating that the flow resistance offered by the collateral arteries had increased. In a bilateral sympathectomised patient the increase in collateral resistance was almost absent indicating that the constriction of the collateral arteries is mainly mediated via sympathetic vasoconstrictor fibres.
United Nations fails to agree on human cloning
Authors: Susan Mayor
Journal: BMJ (2004)

A United Nations committee debated an international convention on human cloning at a meeting last week but failed to reach an agreement. Commentators were predicting, as the BMJ went to press, that a vote might take place next week.

The meeting debated two proposals on human cloning. The first proposal, from Costa Rica and supported by the United States and more than 60 other countries, recommended a complete ban on both reproductive and therapeutic cloning.

A second proposal from Belgium, co-sponsored by the United Kingdom, suggested a ban on reproductive cloning but would allow UN member countries to make their own decisions on therapeutic cloning. It had the support of about 20 countries. Many countries were still undecided as the BMJ went to press.

At the meeting France agreed …