tbuckley/cabot-search huggingface dataset:
Book Review Pediatric AIDS: The challenge of HIV infection in infants, children, and adolescents Third edition. Edited by Philip A. Pizzo and Catherine M. Wilfert. 849 pp., illustrated. Philadelphia, Lippincott Williams &amp; Wilkins, 1999. $99. 0-683-30399-6
Authors: Joanne E. Embree
Journal: New England Journal of Medicine (1999)
Doctors and politics
Authors: A. Jain
Journal: BMJ (2014)

Promises on a platter. It is election season in the world’s largest democracy and politicians are willing to bend over backwards to woo voters. As India moves decisively towards a new government, we bring to you in The BMJ a series of articles aimed at stimulating discussion on what the general elections should mean for health and healthcare, and hoping to inform the health agenda of the next government.

Health has traditionally been relegated to the sidelines with neither politicians nor citizens making a noise about it, when it is indeed central to the vitality of our population. However, it is beginning to climb up the political agenda, reports Patralekha Chatterjee, as she examines how the future of health is carved out in the election manifestos of various …
Fluvoxamine Treatment for Chronic PTSD: A Pilot Study
Authors: Marc De Boer, Wybrand Op den Velde, Paul J.R. Falger, Johannes E. Hovens, Johannes H.M. De Groen, Hans Van Duijn
Journal: Psychotherapy and Psychosomatics (1992)

A group of 24 Dutch World War II Resistance veterans with a documented traumatic war history and a (partially) positive diagnosis of current posttraumatic stress disorder (PTSD) was studied. This special group of war victims is characterised by chronicity, suffering from intractable posttraumatic complaints for decades. They were treated with fluvoxamine (Fevarin), a selective serotonin reuptake inhibitor with antidepressive and anxiolytic properties. The study was designed as an open-ended, outpatient pilot study, with a treatment period of 12 weeks. Results of clinical examination, and questionnaires investigating PTSD, depression, sleeping problems, anxiety, and vital exhaustion indicate that a significant number of the subjects improved with respect to their PTSD symptomatology, and their symptoms of anxiety and vital exhaustion. However, at the end of the study, quantitative improvement was modest. The results indicate that treatment with fluvoxamine may offer alleviation of chronic PTSD symptoms, in particular insomnia, nightmares, anxiety, intrusive recollections, guilt feelings and tiredness.
Vitamin D Status and Clinical Severity in ST Segment Elevation Myocardial Infarction
Authors: Burak Hünük, Özgür Çağaç, İsmail Erdoğu, Onur Öztürk, Murat Sünbül, Dursun Akaslan, Erdal Durmuş, Tarık Kıvrak, Bülent Mutlu
Journal: Journal of the American College of Cardiology (2013)
THE EXTRACELLULAR RELATION OF THE MALARIAL PARASITE TO THE RED CORPUSCLE, AND ITS METHOD OF SECURING ATTACHMENT TO THE EXTERNAL SURFACE OF THE RED CORPUSCLE
Authors: Mary Rowley-Lawson
Journal: The Journal of Experimental Medicine (1913)

Since the malarial parasite was first described in I88O, many views have been held as to the morphology of the ring-form parasite, and its possible formation and significance, but with a remarkable similarity of opinion among observers as to the parasite being intracellular.Laveran ( I ) has consistently claimed from the beginning that the parasites were extracellular and that they attached themselves to the surface of the red corpuscles, adhering to them " b y pressing on them."Richard (2) thought at one time that the parasites were within the substance of the red corpuscle; but later (3) he returned to Laveran's opinion that they were attached to the surface.Mannaberg (4) inclines to the opinion that the young unpigmented parasites "lie for a considerable time upon the blood corpuscles . . . .In the places where the parasites were observed, distinct impressions in the substance of the blood corpuscles are noticed, and that the margin of the so-formed depression is perfectly sharp . . . .If these bodies were within the substance of the blood corpuscle, one cannot understand how the observed depression in the upper surface or edge of the blood corpuscle takes place."Marchiafava and Bignami (5) describe a similar condition, depicting the parasites as being embedded or pressed into the surface of the red corpuscle; but these observers believe the greater number of parasites, even the young forms, to be endoglobular.When Koch was in this country he was shown models of the red corpuscles with the malarial parasites beneath the surface, and he made the statement that the parasites were not within the substance of the red corpuscle but attached to the surface.
Amyotrophic Lateral Sclerosis
Authors: Jacob A. Brody
Journal: JAMA (1978)

The rate of amyotrophic lateral sclerosis (ALS) among stateside construction workers on Guam was similar to that of US resident white men. Of 12,601 men who worked on Guam for one year or more from 1945 to 1954, we were able to follow up 10,049 until 1970 through the Social Security Administration. Of these workers, 1,958 had died, and the cause of death was recorded for all but 335. There were three deaths from ALS. Residence on Guam as an adult did not predispose to a high rate of ALS. (<i>JAMA</i>240:551-552, 1978)
Ocular Cicatricial Pemphigoid Occurring as a Sequela of Stevens-Johnson Syndrome
Authors: Lawrence S. Chan, H. K. Soong, C. S. Foster, C. Hammerberg, K. D. Cooper
Journal: JAMA (1991)

Ocular cicatricial pemphigoid is a chronic scarring inflammation of the ocular mucosae that can lead to blindness. Although cicatricial pemphigoid has been classified clinically, histopathologically, and immunopathologically, no definite initiating factor or precipitating factor has been identified. In this report, we describe five cases of ocular cicatricial pemphigoid that developed following an acute episode of severe ocular inflammatory injury secondary to Stevens-Johnson syndrome. The time lag between the onset of Stevens-Johnson syndrome and cicatricial pemphigoid ranged from a few months to 31 years. All five patients had linear immune deposits characteristic of cicatricial pemphigoid along the basement membrane zone of mucosal biopsy specimens as detected by either direct immunofluorescence microscopy or direct immunoperoxidase staining. In two patients whose serum was tested, a Western blot assay taken of keratinocyte antigens that had undergone electrophoresis reacted with the serum and identified a 120-kd epidermal antigen detected by the IgG class antibodies. All five patients were treated with systemic immunosuppressive therapy for cicatricial pemphigoid, and we obtained objective responses. Severe ocular mucosal injury such as that which occurs in Stevens-Johnson syndrome may be a precipitating factor in the development of ocular cicatricial pemphigoid.
Comparison of Exhaled Breath Condensate and Sputum Induced by Hyperosmotic Saline Inhalation as Indicators of Airway Inflammation Associated with Bronchial Asthma
Authors: T. Shimoda, Y. Obase, M. Imaoka, R. Kishikawa, S. Nishima
Journal: Journal of Allergy and Clinical Immunology (2009)
QUESTIONS IN THE TREATMENT OF CONGENITAL DISLOCATIONS OF THE HIP.
Authors: HARRY M. SHERMAN
Journal: JAMA (1898)

In the treatment of congenital dislocation of the hip by modern methods, reduction of the dislocation by manipulative or operative means, we must wait long for a success to become an assured one; we may not have to wait long for failure. Therefore any one reporting success can do so, at the present time, only with the qualification that the case is "successful up to date." Tomorrow, or the day after, may witness a reluxation, and the work will have to be finally counted a failure or will have to be done over. I have practiced the operative and manipulative reduction only during the past two years, and my experience will let me speak of but the beginning of my cases which I would count successes; of my failures I can speak with more definiteness. I do not intend to detail methods or case histories<i>in extenso</i>. The literature of
Acute haemolytic transfusion reaction by Le<sup>a</sup> alloantibody
Authors: Beenu Thakral, Ashish Jain, Karan Saluja, Ratti Ram Sharma, T. Shyam K. Singh, Neelam Marwaha
Journal: American Journal of Hematology (2006)

A recent article in Blood, ''How I Treat Idiopathic Thrombocytopenic Purpura (ITP)'' by Cines and Bussel, was read with great interest [1].Placing in perspective the new treatment modalities is useful to all hematologists, yet the only published data the authors cited to support their recommendations were a meta-analysis of patients with platelet counts below 30,000, which did not differentiate between treated and untreated patients.There are no publications extant that suggest that treatment-naive, otherwise healthy adult ITP patients with any platelet count are at risk for significant bleeding.In 1988, Brox et al. showed a significant rise in the platelet count with high doses of ascorbic acid in refractory ITP patients [2].Subsequent to Brox's report a study of ascorbic acid for the treatment of refractory ITP was published by Jubilirer [3], which failed to confirm Brox's data; however, it is to be noted that no bleeding episodes occurred in the treatment arm.In 1983 Burns and Saleem [4] published a review of the natural history of refractory ITP patients (steroid and splenectomy failures) and concluded that significant hemorrhagic events were extremely rare.In 2001 Vianelli et al. [5] reported on the long-term follow-up of 310 patients with ITP and concluded that ''prospective studies are required to evaluate whether it may be reasonable to treat only symptomatic patients independently of age.''Since 1988 (Auerbach), steroids have not been used in any of more than 40 patient referrals irrespective of platelet counts without thrombocytopenia-related morbidity.For platelet counts > 10,000, vitamin C alone was prescribed and bruising was virtually eliminated.This result is not unexpected inasmuch as improvement in capillary fragility and wound healing are well-recognized salutary effects with vitamin C. For counts < 10,000 WinRho and/or Rituxan has been universally successful.Therefore, it may not be unreasonable to suggest that our conventional approach to managing ITP in otherwise healthy adults (corticosteroids/ splenectomy) must be reexamined.Even in the pre IVIG, WinRho, and Rituxan era, bleeding was rarely encountered during splenectomies in ''refractory'' ITP patients.Our most important admonition, ''before else, do no harm,'' should be heeded before recommending potentially toxic therapies.
Charlie's List
Authors: David S. Pisetsky
Journal: Annals of Internal Medicine (2010)

On Being a Doctor7 September 2010Charlie's ListDavid S. Pisetsky, MD, PhDDavid S. Pisetsky, MD, PhDFrom Duke University Medical Center, Durham, NC 27705.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-153-5-201009070-00012 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Always bring a list to your doctor's visit,” the patient guidebooks recommend. “That way, you won't forget important things to discuss with your doctor.” I agree. Lists are a good idea, but until I saw Charlie's list I had never been so saddened by what was written.Charlie was an 85-year-old World War II veteran. He had osteoarthritis of the hip that used to plague him until he had a joint replacement. His hands still ached, and he took glucosamine that he bought at Walmart.Charlie had an excellent primary care doctor who took care of his medical needs. Nevertheless, ... Author, Article, and Disclosure InformationAffiliations: From Duke University Medical Center, Durham, NC 27705.Corresponding Author: David S. Pisetsky, MD, PhD, Duke University Medical Center, 151 G, Durham Veterans Affairs Medical Clinic, 508 Fulton Street, Durham, NC 27705; e-mail, [email protected]duke.edu. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 7 September 2010Volume 153, Issue 5Page: 344KeywordsArthritisBloodHipHomicideOsteoarthritisPlaguePosttraumatic stress disorderPsychiatry and mental health ePublished: 7 September 2010 Issue Published: 7 September 2010 Copyright & PermissionsCopyright © 2010 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
P72. Transgenic expression of a chimeric signaling receptor to facilitate T cell costimulation in the tumour environment
Authors: R Schlenker, M Leisegang, W Uckert, E Noessner
Journal: Journal for ImmunoTherapy of Cancer (2014)

Meeting abstracts Tumour therapy with T cell receptor (TCR) engineered T cells is reported to induce clinical responses but shortcomings regarding poor in vivo persistence and loss of function in the tumour milieu have been observed. Providing costimulation to adoptively transferred T cells may
Behavioral changes following participation in a home health promotional program in King County, Washington.
Authors: R Leung, J Q Koenig, N Simcox, G van Belle, R Fenske, S G Gilbert
Journal: Environmental Health Perspectives (1997)

This study examined behavioral changes in households after participation in a home environmental assessment. Home assessment visits by a trained coach, which involved a walk-through in the home with the home residents, were conducted in 36 homes. The walk-through included a list of recommended behavioral changes that the residents could make to reduce their exposures to home pollutants in areas such as dust control, moisture problems, indoor air, hazardous household products, and hobbies. Recruited households were surveyed 3 months after the home assessment to evaluate their implementation of the recommendations. Following the home visits, 31 of 36 households reported making at least one behavioral change, and 41% of the recommendations made by the volunteer coaches were implemented. In conclusion, this study found that the majority of the households who participated in the home assessment reported implementing at least one recommendation. This home health promotional method was effective in influencing behavioral changes.
Hidden duodenal gastrointestinal stromal tumor
Authors: Fatih Karaahmet, Mevlut Hamamci, Yusuf Coşkun, Hakan Akıncı, Ilhami Yuksel
Journal: Endoscopy (2015)

A 62-year-old woman was evaluated for iron deficiency anemia. She had no history of any medications, trauma, smoking, or alcohol consumption. On physical examination, the patient had a pale appearance, and tenderness in the epigastric region but no rigidity or rebound. Upper gastrointestinal endoscopy revealed the majority of the stomach and duodenal bulb to be normal. However, a well-hidden, red-colored, ulcerated lesion (diameter 2 cm) was observed. The lesion was located mainly on the posterior side of the duodenal bulb, partly occupying the duodenal bulb, and extended to the descending duodenum ([Fig. 1] and [Video 1]). The appearance and size of the lesion suggested a gastrointestinal stromal tumor (GIST), and it was therefore removed surgically. Histopathological examination of the resected tissue confirmed GIST. The patient was discharged 3 days after the surgery, and was doing well at follow-up.
Lipid Bodies Are Reservoirs of Cyclooxygenase-2 and Sites of Prostaglandin-E2 Synthesis in Colon Cancer Cells
Authors: Maria T. Accioly, Patricia Pacheco, Clarissa M. Maya-Monteiro, Nina Carrossini, Bruno K. Robbs, Silvia S. Oliveira, Cristiane Kaufmann, José A. Morgado-Diaz, Patricia T. Bozza, João P.B. Viola
Journal: Cancer Research (2008)

Lipid bodies (lipid droplets) are emerging as dynamic organelles involved in lipid metabolism and inflammation. Increased lipid body numbers have been described in tumor cells; however, its functional significance in cancer has never been addressed. Here, we showed increased number of lipid bodies in tumor tissues from patients with adenocarcinoma of colon submitted to surgical resection when compared with an adjacent normal tissue. Accordingly, increased numbers of lipid bodies were observed in human colon adenocarcinoma cell lines and in a H-rasV12-transformed intestinal epithelial cell line (IEC-6 H-rasV12) compared with nontransformed IEC-6 cells. The functions of lipid bodies in eicosanoid synthesis in cancer cells were investigated. CACO-2 cells have increased expression of cyclooxygenase-2 (COX-2) when compared with IEC-6 cells. We showed by immunolocalization that, in addition to perinuclear stain, COX-2 and prostaglandin E (PGE) synthase present punctate cytoplasmic localizations that were concordant with adipose differentiation-related protein-labeled lipid bodies. The colocalization of COX-2 at lipid bodies was confirmed by immunoblot of subcellular fractionated cells. Direct localization of PGE(2) at its synthesis locale showed that lipid bodies are sources of eicosanoids in the transformed colon cancer cells. Treatment with either aspirin or the fatty acid synthase inhibitor C75 significantly reduced the number of lipid bodies and PGE(2) production in CACO-2 and in IEC-6 H-rasV12 cells with effects in cell proliferation. Together, our results showed that lipid bodies in colon cancer cells are dynamic and functional active organelles centrally involved in PGE(2) synthesis and may potentially have implications in the pathogenesis of adenocarcinoma of colon.
Bilateral Cerebral Blood Flow and Oxygen Consumption in Man by use of Krypton <sup>85</sup>
Authors: OLE MUNCK, NIELS A. LASSEN
Journal: Circulation Research (1957)

Side-to-side differences of estimated cerebral blood flow and oxygen consumption are found in most of 38 bilateral studies with the method of Kety and Schmidt using Kr 85 as inert gas instead of nitrous oxide. The results indicate that bilateral values reflect the blood flow and oxygen consumption of the whole brain much more reliably than unilateral values. Accurate, bilateral determinations may prove of value, especially for the individual evaluation of the results obtained in a given subject.
Endoscopic treatment of biliary obstruction in a patient with sump syndrome
Authors: K. Fujita, Y. Harano, T. Morikawa, J. Andou, S. Myojo, S. Yoshida
Journal: Endoscopy (2012)

Recurrent cholangitis occasionally occurs after choledochoduodenostomy, because of stagnant bile between the choledochoduodenostomy anastomosis and papilla – a condition which is known as sump syndrome [1]. Several reports describe endoscopic sphincterotomy as useful for sump syndrome [2] [3] [4]. Here we describe an 84-year-old man showing sump syndrome with choledocholithiasis and biliary orifice obstruction, in whom endoscopic sphincterotomy was impossible.
What's wrong with medical education in Britain?
Authors: S. Lowry
Journal: BMJ (1992)

BMJ 1992;305:1277-80 Something is seriously wrong with medical education in Britain. Professor Lesley Rees, dean of St Bartholomew's Hospital Medical College, London, recalls with horror the transformation of eager, motivated school leavers into narrow minded, dis? illusioned medical graduates. Immediately I became sub-dean at Barts there was a great stamping of feet into my office, with complaints about everything. I cannot remember half of them, but it was a depressing experience to hear young men and women complaining of all the inadequacies that they perceived in the educational process that they had been through for five years. The General Medical Council admits that the traditional medical course is stifling students: Imagination and curiosity are soon dulled and learn? ing patterns quickly adapt to the need to absorb knowledge, often at a superficial level_* A recent national consensus inquiry organised by the King's Fund confirmed that such worries about the under? graduate medical curriculum are widespread: There is widespread agreement that present curricula are grossly overcrowded with factual information which soon becomes out of date and inhibits students from developing into creative critical thinkers and problem solvers.2
HYSTERIA, ITS NATURE AND ITS POSITION IN NOSOLOGY.
Authors: F. X. DERCUM
Journal: JAMA (1907)

This paper is prompted by the fact that of late various views have been enunciated which bear vitally on both the nature of hysteria and on its position in our nosology. It has seemed to me that the recent tendency has been to include under the term of hysteria symptoms that really belong to other affections, and further to apply interpretations that are fundamentally defective. Thus, a change in the personality such as gives rise to a multiple personality must certainly be admitted to be the exception and not the rule, and to claim disintegration as the essential feature of hysteria seems to me to be an error. It mistakes that which is merely an occasional epiphenomenon as the essential cause of the affection. Again the view that has lately been advanced by Babinski, that the symptoms of hysteria owe their origin entirely to suggestions from without, especially to suggestions
Stat5 Is Required for IL-2-Induced Cell Cycle Progression of Peripheral T Cells
Authors: Richard Moriggl, David J Topham, Stephan Teglund, Veronika Sexl, Catriona McKay, Demin Wang, Angelika Hoffmeyer, Jan van Deursen, Mark Y Sangster, Kevin D Bunting, Gerard C Grosveld, James N Ihle
Journal: Immunity (1999)
Digoxin-like immunoreactive substance in patients with aneurysmal subarachnoid haemorrhage.
Authors: E F Wijdicks, M Vermeulen, P van Brummelen, N C den Boer, J van Gijn
Journal: BMJ (1987)

Digoxin was measured by radioimmunoassay in the plasma of 25 patients with aneurysmal subarachnoid haemorrhage who had not received digoxin treatment. After heating the plasma an endogenous substance cross reacting with antibodies to digoxin was identified in 18 cases. The presence of this substance was significantly related to the total amount of blood and to the presence of blood in the frontal interhemispheric fissure and could not be explained by hypertension or intake of water and sodium. A negative sodium balance and volume depletion occurred more often in patients who were positive for digoxin, but this relation did not reach statistical significance. It is concluded that a digoxin-like natriuretic factor is released in response to a subarachnoid haemorrhage, probably as a result of hypothalamic damage.
New public health agency backs calls for minimum price on alcohol
Authors: G. Iacobucci
Journal: BMJ (2013)

The new national agency in charge of public health in England has backed proposals to establish a minimum price on a unit of alcohol to try to curb the harmful effects of drinking.

Public Health England, which is set to take on national responsibility for tackling public health challenges from 1 April, said that the available evidence supported the introduction of a minimum price per unit of alcohol and urged the government to use this evidence as its guide, as ministers weigh up whether to implement the measure.

Earlier this month the prime minister, David Cameron, told MPs in the House of Commons that the government was still examining the results of its consultation on whether to set a minimum price of 45p (€0.55; $0.72) a unit in England and Wales, amid rumours of …