Acyclovir and Suppression of Frequently Recurring Herpetic Whitlow
Authors: OSCAR L. LASKIN
Journal: Annals of Internal Medicine (1985)

Brief Reports1 April 1985Acyclovir and Suppression of Frequently Recurring Herpetic WhitlowOSCAR L. LASKIN, M.D.OSCAR L. LASKIN, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-102-4-494 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHerpetic whitlow is a cutaneous infection, usually of the hand, caused by herpes simplex virus. Like other forms of infections caused by herpes viruses, the lesions can be recurrent and the virus can reactivate frequently, resulting in significant morbidity. Herpetic whitlow is an occupational hazard for medical and dental personal and may interfere with patient care. We report the use of oral acyclovir to prevent frequent recurrences of herpetic whitlow in an otherwise healthy patient.A 30-year-old white woman, a surgical resident with a 4-year history of recurrent herpetic whitlow involving her left thumb, was seen at the New York...References1. LASKIN O. Acyclovir: pharmacology and clinical experience. Arch Intern Med. 1984;144:1241-6. CrossrefMedlineGoogle Scholar2. DOUGLASCRITCHLOWBENEDETTI JCJ. A double-blind study of oral acyclovir for suppression of recurrences of genital herpes simplex virus infection. N Engl J Med. 1984;310:1551-6. CrossrefMedlineGoogle Scholar3. STRAUSTARIFFSEIDLIN SHM. Suppression of frequently recurring genital herpes: a placebo-controlled double-blind trial of oral acyclovir. N Engl J Med. 1984;310:1545-50. CrossrefMedlineGoogle Scholar4. SARALBURNSLASKINSANTOSLIETMAN RWOGP. Acyclovir prophylaxis of herpes-simplex-virus infections: a randomized, double-blind controlled trial in bone-marrow-transplant recipients. N Engl J Med. 1981;305:63-7. CrossrefMedlineGoogle Scholar5. AMBINDERBURNSLIETMANSARAL RWPR. Prophylaxis: a strategy to minimize antiviral resistance. Lancet. 1984;1:1154-5. CrossrefMedlineGoogle Scholar6. BURNSSARALSANTOS WRG. Isolation and characterisation of resistant Herpes simplex virus after acyclovir therapy. Lancet. 1982;1:21-3. Google Scholar7. PARRISHARRINGTON DJ. Herpes simplex virus variants resistant to high concentrations of acyclovir exist in clinical isolates. Antimicrob Agents Chemother. 1982;22:71-7. CrossrefMedlineGoogle Scholar8. SIBRACKGUTMANWILFERT CLC. Pathogenicity of acyclovir-resistant herpes simplex virus type 1 from an immunodeficient child. J Infect Dis. 1982;146:673-82. CrossrefMedlineGoogle Scholar9. FIELDWILDY HP. The pathogenicity of thymidine kinase-deficient mutants of herpes simplex virus in mice. J Hyg (Lond). 1978;81:267-77. CrossrefMedlineGoogle Scholar10. TENSERMILLERRAPP RRF. Trigeminal ganglion infection by thymidine kinase-negative mutants of herpes simplex virus. Science. 1979;205:915-7. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Cornell University Medical College New York, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHand InfectionsBenign Acquired Superficial Skin Lesions of the HandThe Herpetic WhitlowL'herpès de la main : une pathologie professionnelle méconnueRecurrent herpes simplex virus type 2 infection of the hand complicated by persistent lymphoedemaHand Infections: Basic Principles and ManagementHerpes simplex virus: an occupational hazard in dentistryINFECTIONS OF THE FINGERTIPDestructive herpetic whitlow in AIDS: report of three casesNew Aspects of Oral Viral DiseasesClinical Pearls: Index-finger Pain and BlistersHand InfectionsSystemic Antivirals in Herpesvirus InfectionsHand InfectionsHerpetic whitlow with bacterial abscessOral acyclovir therapy of recurrent herpes simplex virus type 2 infection of the handAcyclovir: The Past Ten YearsOrofacial herpes simplex virus infections: Current concepts in the epidemiology, pathogenesis, and treatment, and disorders in which the virus may be implicatedOther Viral InfectionsViral InfectionsAntiviral therapyThe Future of Antiviral ChemotherapyAntiviral AgentsProphylactic and suppressive treatment with acyclovir and the management of herpes in patients with acquired immunodeficiency syndromeDrugs Five Years Later: AcyclovirDAVID I. DORSKY, M.D., Ph.D., CLYDE S. CRUMPACKER, M.D.Antiviral AgentsTreatment of Herpes Simplex Virus InfectionsAcyclovir and the treatment of herpetic whitlow9-[2-Hydroxy-1-(Hydroxymethyl)-Ethoxymethyl]Guanine: Clinical Experience in AIDS Patients with Severe Cytomegalovirus InfectionsAcyclovir prophylaxis for herpes simplex virus infectionMan bites dog.Acyclovir update.Management of oral and genital herpes simplex virus infections: Diagnosis and treatmentTherapy for Recurrent Herpetic WhitlowM. J. GILL, M.B., M.SC., F.R.C.P.(C), J. ARLETTE, M.D., F.R.C.P.(C), K. BUCHAN, M.B., Ch.B., D. L. TYRRELL, M.D., Ph.D., F.R.C.P.(C)Chemotherapy of herpesvirus infections: Present successes and future hopes 1 April 1985Volume 102, Issue 4Page: 494-495KeywordsFellowshipsHerpes simplexLesionsMorbidityOral healthPatients Issue Published: 1 April 1985 PDF downloadLoading ...