tbuckley/cabot-search huggingface dataset:
Regionalized Self-care Hemodialysis
Authors: Jean-Pierre Wauters
Journal: JAMA (1983)

To cope with an ever-increasing number of patients with end-stage renal disease, a regionalized self-care hemodialysis program was set up and combined with the existing home and center hemodialysis, peritoneal dialysis, and renal transplantation. Five years later, of a total of 105 patients treated by hemodialysis, 66 were dialyzing themselves—31 at home and 35 in seven local self-care facilities. This proportion of patients engaging in autonomous treatment (69%) was obtained without restrictive selection criteria, since we treat 210 patients per million population with hemodialysis. The annual intake of new patients could be managed without increasing the number of center dialysis beds and by only slightly increasing the specialized staff. The cost reduction obtained with this program when compared with all center dialysis treatment represents 37%, or approximately 1,200,000 US dollars per year. These results were obtained without compromising the quality of treatment. (<i>JAMA</i>1983;250:59-62)
Risks of coronary arteriography.
Authors: C A Layton
Journal: BMJ (1980)

was given without obvious benefit there was synergism between mexiletine and practolol similar to the co-operative action between mexiletine and propranolol in refractory ventricular tachycardia proposed in your recent article.We found no adverse effects with the intravenous administration of mexile- tine in these patients and the successful dose varied from 60 mg to 250 mg given at a rate of 30 mg/min.
Should patients with cirrhosis and variceal hemorrhage receive glucocorticoid therapy?
Authors: Richard Moreau, Emmanuel Weiss
Journal: Hepatology (2015)

1Inserm, U1149Centre de Recherche sur l'InflammationParisFrance 2UMR S 1149Université Paris Diderot‐Paris 7, Faculté de Médecine BichatParisFrance 3Département Hospitalo‐Universitaire UNITY, Service d'Hépatologie, Hôpital BeaujonAssistance Publique‐Hôpitaux de ParisClichyFrance 4Laboratoire d'Excellence (Labex) INFLAMEXPRES Sorbonne Paris CitéParisFrance 5Département d'Anesthésie et Réanimation, Hôpital BeaujonAssistance Publique‐Hôpitaux de ParisClichyFrance
Just the Flax, Ma'am: Researchers Testing Linseed
Authors: J. Ziegler
Journal: JNCI Journal of the National Cancer Institute (1994)

Journal Article Just the Flax, Ma'am: Researchers Testing Linseed Get access Jan Ziegler Jan Ziegler Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 86, Issue 23, 7 December 1994, Pages 1746–1748, https://doi.org/10.1093/jnci/86.23.1746 Published: 07 December 1994
The role of microRNA-23b in the differentiation of MSC into chondrocyte by targeting protein kinase A signaling
Authors: Onju Ham, Byeong-Wook Song, Se-Yeon Lee, Eunmi Choi, Min-Ji Cha, Chang Youn Lee, Jun-Hee Park, Il-Kwon Kim, Woochul Chang, Soyeon Lim, Chang Hyun Lee, Soonhag Kim, Yangsoo Jang, Ki-Chul Hwang
Journal: Biomaterials (2012)
Inhibition of IL-12 production by 1,25-dihydroxyvitamin D3. Involvement of NF-kappaB downregulation in transcriptional repression of the p40 gene.
Authors: D D'Ambrosio, M Cippitelli, M G Cocciolo, D Mazzeo, P Di Lucia, R Lang, F Sinigaglia, P Panina-Bordignon
Journal: Journal of Clinical Investigation (1998)

Interleukin 12 (IL-12), produced by myelomonocytic cells, plays a pivotal role in the development of T helper 1 (Th1) cells, which are involved in the pathogenesis of chronic inflammatory autoimmune disorders. 1,25-Dihydroxyvitamin D3 [1,25(OH)2D3] inhibits IL-12 production by activated macrophages and dendritic cells, thus providing a novel interpretation to its immunosuppressive properties. 1,25(OH)2D3 significantly inhibits mRNA expression for both IL-12 p35 and p40 subunits acting at the transcriptional level. The effect of 1,25(OH)2D3 on p40 promoter activation was analyzed by cotransfecting monocytic RAW264.7 cells with p40 promoter/reporter constructs and expression vectors for vitamin D3 receptor (VDR) and/or retinoid X receptor (RXRalpha). We observed transcriptional repression of the p40 gene by 1,25(OH)2D3, which required coexpression of VDR with RXR and an intact VDR DNA-binding domain. The repressive effect maps to a region in the p40 promoter containing a binding site for NF-kappaB (p40-kappaB). Deletion of the p40-kappaB site abrogates part of the inhibitory effect on the p40 promoter, confirming the functional relevance of this site. Activation of monocytic THP-1 cells in the presence of 1,25(OH)2D3 results in reduced binding to the p40-kappaB site. Thus, 1,25(OH)2D3 may negatively regulate IL-12 production by downregulation of NF-kappaB activation and binding to the p40-kappaB sequence.
Controversies in Nephrology and Hypertension
Authors: Bernard H. Adelson
Journal: JAMA (1985)

To understand the controversies that are inherent to a discipline is to understand the discipline itself. A consequence of this truism is that any collection of essays designed to articulate the controversial aspects of modern nephrology should be useful if the resultant book is thoughtfully planned and diligently constructed. Dr Robert G. Narins has done just that in his book<i>Controversies in Nephrology and Hypertension</i>. A compilation of essays arranged in point-counterpoint fashion, this book comprises five sections: "Social, Economic, and Ethical Controversies and End-Stage Renal Disease," "Controversies in Hypertension," "Controversies in Diagnosing Renal-Metabolic Disorders," "Controversies in Treating Renal-Electrolyte Disorders," and "Controversies in Physiology and Pathophysiology." Its 48 essayists include nephrologists, urologic surgeons, and a pathologist. All nephrologists should read the summary of the legislative and regulatory history of the End-Stage Renal Disease Program and the discussion of the economic models for the delivery of dialytic therapy. The presentation of
Polybrominated dibenzo-p-dioxins and dibenzofurans: literature review and health assessment.
Authors: J H Mennear, C C Lee
Journal: Environmental Health Perspectives (1994)

Polybrominated dibenzo-p-dioxins (PBDDs) and dibenzofurans (PBDFs) occur as trace (ppb) contaminants in brominated flame retardants and are produced during combustion of these chemicals. They are also formed when organics are incinerated in the presence of bromine, e.g., in municipal and industrial incinerators and in internal-combustion engines. Combustion of organics in the presence of both bromine and chlorine results in the formation of mixed (i.e., bromo, bromo/chloro and chloro) halogenated dibenzo-p-dioxins and dibenzofurans (HDDs and HDFs). There are 4600 potential mixed congeners. The biological effects of PBDDs and PBDFs are similar, if not identical, to those of PCDDs and PCDFs. Both groups of compounds induce hepatic aryl hydrocarbon hydroxylase (AHH) and ethoxyresorufin-o-deethylase (EROD) in rats and cause wasting and thymic atrophy in rats and guinea pigs. Tetrabrominated dinenzo-p-dioxin (TBDD) and dibenzofuran (TBDF) are reproductive toxins in mice and produce skin lesions in the rabbit-ear acnegenic test. The brominated compounds appear to bind to the same cytosolic receptors believed to mediate the toxicities of the chlorinated analogs. When compared on a molar-concentration basis, the brominated compounds are equipotent to the chlorinated analogs. TBDD is absorbed after oral, dermal, or intratracheal administration in rats, stored in the liver and adipose tissue, and eliminated in the feces through biliary excretion. The biological half-lives of the brominated compounds appear to be somewhat shorter than those of the corresponding chlorinated species. The brominated compounds, like their chlorinated congeners, have the potential to cause dermal, hepatic, and gastrointestinal toxicities in humans.(ABSTRACT TRUNCATED AT 250 WORDS)
What's reason got to do with it? Affect as the foundation of learning
Authors: Eliza Bliss-Moreau, Lisa Feldman Barrett
Journal: Behavioral and Brain Sciences (2009)

Abstract We propose that learning has a top-down component, but not in the propositional terms described by Mitchell et al. Specifically, we propose that a host of learning processes, including associative learning, serve to imbue the representation of the conditioned stimulus (CS) with affective meaning.
TMEM70 mutations cause isolated ATP synthase deficiency and neonatal mitochondrial encephalocardiomyopathy
Authors: Alena Čížková, Viktor Stránecký, Johannes A Mayr, Markéta Tesařová, Vendula Havlíčková, Jan Paul, Robert Ivánek, Andreas W Kuss, Hana Hansíková, Vilma Kaplanová, Marek Vrbacký, Hana Hartmannová, Lenka Nosková, Tomáš Honzík, Zdeněk Drahota, Martin Magner, Kateřina Hejzlarová, Wolfgang Sperl, Jiří Zeman, Josef Houštěk, Stanislav Kmoch
Journal: Nature Genetics (2008)
Some Observations regarding the Permanence of the Radical Cure of Hernia
Authors: C. Puzey
Journal: BMJ (1887)

THIS BRITISH MBDICAL JOt1NAL.1327 strict Listerism was followed out, and as a rule not more than one or two dressings were required.The ages of the patient varied from 3 months to 76 years, the rup- tures being ventral, femoral, inguinal, or inguino-scrotal.The greater number appeared to be permanently cured, and it seemed to be quite unnecessary to recommend a truss, unless, as in Case 3, the opening into the abdomen had been unusually large.Cases 5 and 13 require special notice, as they both succumbed to bronchitis, but in both the necropsy clearly proved that the site of operation was quite satisfactory, that the bowel had recovered itself, and that there was no peritonitis.In the latter case a woman, aged 65, was admitted with strangulated hernia and acute bronchitis, and an operation could not be delayed, as the hernia had been strangu- lated for three days.Chloroform was given, and although the patient lived to heal the wound, the chest ailment proved fatal on the sixth day.In Case 5, an emphysematous subject, aged 56, with a large scrotal hernia, unfortunately had ether given instead of chloroform, and although the patient may have caught a chill in going from the operat- ing theatre to the ward, it being a cold day, I cannot help blaming the anesthetic for the acute bronchitis which supervened.Whenever, for the cure of some deformity or disease, several different operations are advocated, it would, as a rule, seem to point to two conclusions-first, that the ailment urgently demands treat- ment; and secondly, that no one operation possesses such marked superiority as to monopolise the field Whilst agreeing with the former hypothesis I should hesitate to accept the latter, for of all the operations I have seen done, or have myself performed, for the radical cure of hernia, the only one that I have found really satisfactory is that of excision of the sac after the ligature of its neck as high as possible, with suture of the pillars ot the ring if widely separated.This, if done with due antiseptic precautions, is both safe and efficient; and, if the sac be separated from its surroundings before it is emptied, the operation is both shortened and simplified.
BOOK REVIEW: Prevention and Detection of Colorectal Cancer.
Authors: J Northover
Journal: Gut (1997)

Neurological complications of enteric disease EDITOR,-I read the leading article on neuro- logical complications of enteric disease by Drs Wills and Hovell (Gut 1996; 39: 501-4) immediately after seeing a young woman with achalasia of the cardia and ataxia as a result of cerebellar degeneration in my outpatient clinic.Such an association is not described in the article.As gastroenterologists, we consider achalasia an "enteric disease" in the broadest sense of the phrase, but it is, of course, primarily a disease of the enteric nervous system.This perhaps explains why achalasia and other gastrointestinal disorders which are caused by enteric nervous dysfunction are not described in the article, even though several such disorders have neurological associations.To complete the picture, I draw your readers' attention to a recent comprehensive review on the enteric nervous system,' in which I was delighted to find the reference to a paper2 which seemed to describe the young woman in my clinic.
Micronutrients and Cancer Prevention
Authors: Charles H. Hennekens
Journal: New England Journal of Medicine (1986)

In the United States today, cancer is the second most frequent cause of death and is responsible for over 20 percent of the approximately 2 million total annual deaths.1 Cigarette smoking, which accounts for about 30 percent of all deaths from cancer in the United States, is the leading known avoidable cause of mortality from all causes as well as from cancer.2 Heavy alcohol consumption, which ranks second, is responsible for about 3 percent of cancer deaths. Promising, but unproved, hypotheses concern the prevention of cancer through diet, which has been postulated to account for as many as 35 percent . . .
More aggressive treatment urged for patients with prostate cancer
Authors: Barbara Bolsen
Journal: JAMA (1981)

Two thirds to three quarters of men with prostate cancer that has not yet metastasized receive only palliative treatment despite the fact that most, if not all, are candidates for either curative radiation therapy or surgery. That fact, turned up by the American College of Surgeons (ACS) in a nationwide survey of prostate cancer care in 1979, concerns both surgeons and therapeutic radiologists, who note that the disease afflicts 77,000 men and claims 22,000 lives annually. "We were surprised that there really isn't more aggressive therapy going on," said Robert L. Schmitz, MD, chairman of the Department of Surgery at Mercy Hospital, Chicago, and chairman of the ACS Commission on Cancer's Committee on Patient Care and Research. The committee collected data on 14,079 patients treated for prostate cancer at 658 hospitals in 1979 and on 20,166 patients treated at 419 hospitals in 1974. "Only 5% to 10% [of patients] get
Abstract 1937: APE/Ref-1, a drugable target for the therapy of human melanoma
Authors: Sun Yang, Zhonghui Zheng, Bobbye Misner, Richard Chamberlin, Frank L. Meyskens
Journal: Cancer Research (2012)

Abstract Human malignant melanoma exhibits impaired redox status and abnormal redox-regulated signal pathways. Induced as an adaptive response to reactive oxygen species (ROS) and reactive nitrogen species (RNS), a multi-functional protein called APE/Ref-1 serves as a redox chaperone and modulator of many nuclear transcription factors and for maintaining intracellular redox status. Our previous studies showed that knockdown of APE/Ref-1 significantly sensitized melanoma cells to chemo-treatment and reduced metastatic potential markedly. In this study, we further characterized the role of APE/Ref-1 in the invasive properties of human melanoma. Two function-deficient Ref-1 constructs were stably transfected into melanoma cells; further studies with Scratch Migration and Matrigel assays showed that both ΔNLS-Ref-1 and RedoxD-Ref-1 markedly decreased migration and invasive c-apacity. Matrix metalloproteinase (MMP)-1 mRNA levels were also significantly reduced in transfectants, which was reversed by APE/Ref-1 cDNA overexpression. Nitric oxide (NO) stress induced by DETA (NO donor) treatment was associated with enhanced invasion potential of melanoma cells, which was significantly reversed by APE/Ref-1 depletion. These results suggest that specific and potent inhibitors targeting redox activity of APE/Ref-1 should be explored for therapeutic potential. Utilizing 3-dimensional modeling and virtual docking, we have screened compounds from 35 chemical vendors with total number of more than 7 million. Through extensive chemical modifications of our top ranked candidates, we have successfully synthesized novel APE/Ref-1 inhibitors (#598-5, #598-21, and #598-24) showing significant inhibition on the redox activity of APE/Ref-1. Notably, #598-21 exhibited promising anti-melanoma activities with IC50 below 1 μM. In addition, our studies have also identified two leading compounds whose mechanism of inactivation of APE/Ref-1 is due to the oxidation of APE/Ref-1 protein itself. Taking these molecules as lead compounds, we are evaluating their in vivo anti-tumor efficacies and synthesizing more potent inhibitors with enhanced activities. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1937. doi:1538-7445.AM2012-1937
Risk behaviours among male clients of female prostitutes.
Authors: M A Barnard, N P McKeganey, A H Leyland
Journal: BMJ (1993)

failures during commercial sex were also apparently common, it is possible that female prostitutes are as much at risk of infection from their clients as clients are at risk from prostitutes.Female prostitutes and their male sexual partners together appear to link otherwise separate parts of large populations through a range of relationships.Further research on these sexual networks and the interconnections between different risk behaviours is needed for the assessment of potential transmission of HIV.We thank participants for their patience and help with this research; Forum magazine for publicity; and Jonathan Weber and David Miller for helpful technical and editorial comments on a draft of this paper.
ADIPONECTIN PROMOTES COXSACKIEVIRUS B3 MYOCARDITIS BY SUPPRESSING THE ACUTE ANTIVIRAL IMMUNE RESPONSE
Authors: Carsten Skurk, Alexander Jenke, Moritz Becher, Alice Weithäuser, Karin Klingel, Heinz-Peter Schultheiss, Carmen Scheibenbogen
Journal: Journal of the American College of Cardiology (2013)
Abnormal left ventricular early diastolic filling during dobutamine stress Doppler echocardiography is a sensitive indicator of significant coronary artery disease
Authors: El-Said M. El-Said, Jos R.T.C. Roelandt, Paolo M. Fioretti, Albert J. McNeill, Tamas Forster, Hendrik Boersma, David T. Linker
Journal: Journal of the American College of Cardiology (1994)
THREE PRIMARY SYPHILITIC LESIONS IN ONE PERSON OVER A TEN YEAR PERIOD
Authors: John R. Herman
Journal: JAMA (1942)

"The reporting of a valid reinfection is one of the most difficult accomplishments in the syphilological field, and the larger part of the evidence now in existence for individual cases must rank as presumptive or suggestive rather than conclusive."<sup>1</sup>With this in mind, and with the full realization that the bibliography available on a destroyer is quite limited, the following case is presented for record. No comparable cases have come to my attention or to the attention of various medical men with whom I have been able to consult. <h3>REPORT OF CASE</h3><h3>First Lesion.—</h3> B. R. L., a white man born in 1912, was exposed to venereal infection in Shanghai in December 1932 and forty days later had a primary coronal lesion. Dark field examination was negative, but a Kahn reaction was found to be 4 plus one month later. The patient also developed "general adenopathy." Antisyphilitic treatment was started in 1933 and the patient received 14 Gm. of arsenicals and twenty-four injections of a bismuth compound prior to 1935. He remained untreated until 1937, when for no recorded reason, under
The Decrease in Breast-Cancer Incidence in 2003 in the United States
Authors: Peter M. Ravdin, Kathleen A. Cronin, Nadia Howlader, Christine D. Berg, Rowan T. Chlebowski, Eric J. Feuer, Brenda K. Edwards, Donald A. Berry
Journal: New England Journal of Medicine (2007)

An initial analysis of data from the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) registries shows that the age-adjusted incidence rate of breast cancer in women in the United States fell sharply (by 6.7%) in 2003, as compared with the rate in 2002. Data from 2004 showed a leveling off relative to the 2003 rate, with little additional decrease. Regression analysis showed that the decrease began in mid-2002 and had begun to level off by mid-2003. A comparison of incidence rates in 2001 with those in 2004 (omitting the years in which the incidence was changing) showed that the decrease in annual age-adjusted incidence was 8.6% (95% confidence interval [CI], 6.8 to 10.4). The decrease was evident only in women who were 50 years of age or older and was more evident in cancers that were estrogen-receptor-positive than in those that were estrogen-receptor-negative. The decrease in breast-cancer incidence seems to be temporally related to the first report of the Women's Health Initiative and the ensuing drop in the use of hormone-replacement therapy among postmenopausal women in the United States. The contributions of other causes to the change in incidence seem less likely to have played a major role but have not been excluded.
DR. DeLANCEY ROCHESTER'S "REPORT ON THE TREATMENT OF PULMONARY TUBERCULOSIS."—REPLY.
Authors: PAUL PAQUIN
Journal: JAMA (1897)

Under the above caption appears in theJournal of the American Medical Association, July 10, 1897, the report of Dr. DeLancey Rochester of Buffalo, N. Y., as presented to the Section on Practice of Medicine, at the Forty-eighth Annual Meeting of theAmerican Medical Association, held at Philadelphia, June 1-4, 1897. This report I had the pleasure of hearing and was disappointed in not being able to discuss it, owing to the numerous other papers on tuberculosis presented before that and other Sections of theAssociation, and for the discussion of which only five minutes were granted to each member. The report of Dr. Rochester seems to be a comparative statement of the results he obtained in the use of Edson's aseptolin, Paquin's tubercle antitoxin and Vaughan's nuclein. I have read it carefully and am compelled to reply because of the manifest injustice it does the cause of sero-therapy and
Clinical course of spontaneous reactivation of hepatitis B virus infection in patients with chronic hepatitis B
Authors: Philippe Levy, Patrick Marcellin, Michèle Martinot-Peignoux, Claude Degott, Joëlle Nataf, Jean-Pierre Benhamou
Journal: Hepatology (1990)

The purposes of this study were (a) to describe the clinical and biochemical manifestations associated with spontaneous reactivation of hepatitis B virus as defined by the reappearance of hepatitis B virus DNA in serum using dot-blot hybridization and (b) to determine whether the clinical and biochemical manifestations associated with hepatitis B virus reactivation were different in patients with and without human immunodeficiency virus-1 infection. During 1 yr, 110 French patients were admitted to Hôpital Beaujon for chronic hepatitis B. Fourteen were found to have hepatitis B virus reactivation; of these, three were anti-human immunodeficiency virus-1-positive. These 14 patients were HBsAg-positive for 60 mo (range = 6 to 180 mo). Clinical manifestations related to reappearance of hepatitis B virus DNA were present in 11 patients. HBeAg/anti-HBe status did not change in nine patients in whom hepatitis B virus reactivation would not have been recognized without hepatitis B virus DNA testing. Cirrhosis was present in nine patients. Four patients, of whom two were anti-human immunodeficiency virus-1-positive, had fulminant liver failure. Two patients died; one was anti-human immunodeficiency virus-1-positive. One patient was given an emergency transplant.