The Kidney in Cardiovascular Disease
Authors: Bertram L. Kasiske
Journal: Annals of Internal Medicine (2001)

Editorials17 April 2001The Kidney in Cardiovascular DiseaseBertram L. Kasiske, MDBertram L. Kasiske, MDDr. Kasiske: Hennepin County Medical Center; Minneapolis, MN 55415Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-134-8-200104170-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The past quarter-century has seen remarkable advances in the prevention and treatment of cardiovascular disease. Observational studies have effectively identified modifiable risk factors, such as hypertension and hyperlipidemia. Well-designed randomized, controlled trials have unequivocally shown that treatment of these and other risk factors reduces cardiovascular disease and all-cause mortality. More recent clinical trials are now examining treatment in special populations and are investigating whether some agents may have unique "renoprotective" or "cardioprotective" effects that go beyond targeted reductions in known risk factors.The Heart Outcomes and Prevention Evaluation (HOPE) study is an important trial demonstrating the ineffectiveness of 400 IU ...References1. . Vitamin E supplementation and cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators. N Engl J Med. 2000;342:154-60. [PMID: 0010639540] CrossrefMedlineGoogle Scholar2. . Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators. N Engl J Med. 2000;342:145-53. [PMID: 0010639539] CrossrefMedlineGoogle Scholar3. Mann JF, Gerstein HC, Pogue J, Bosch J, Yusuf S. 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PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoRenal Insufficiency as a Predictor of Cardiovascular Outcomes and the Impact of Ramipril: The HOPE Randomized Trial Johannes F.E. Mann , Hertzel C. Gerstein , Janice Pogue , Jackie Bosch , Salim Yusuf , and Metrics Cited ByCardiorenal syndrome type 4: A study of cardiovascular diseases in chronic kidney diseaseThe association between glomerular filtration rate and left ventricular function in two independent community-based cohorts of elderlyCost-Effectiveness Analysis of a Randomized Trial Comparing Care Models for Chronic Kidney DiseaseAssociations among Estimated Glomerular Filtration Rate, Proteinuria, and Adverse Cardiovascular OutcomesEmerging Strategies in Kidney TransplantationCKD and Mortality Risk in Older People: A Community-Based Population Study in the United KingdomEffect of Pioglitazone on Cardiovascular Outcome in Diabetes and Chronic Kidney DiseaseKidney Disease and Cardiovascular RiskChronic Kidney Disease and Mortality Risk: A Systematic ReviewEffect of Pravastatin on Cardiovascular Events in People With Chronic Kidney DiseaseEffects of vitamin E on cardiovascular outcomes in people with mild-to-moderate renal insufficiency: Results of the HOPE StudyDetecting early chronic kidney disease: are clinical laboratories a problem?Do associations with C-Reactive protein and extent of coronary artery disease account for the increased cardiovascular risk of renal insufficiency?Prevention of the Development and Progression of Renal DiseaseLevel of kidney function as a risk factor for cardiovascular outcomes in the elderlyGrade of chronic renal failure, and acute and long-term outcome after percutaneous coronary interventionsPrimary Renal Disease as a Cardiovascular Risk FactorRenal function: an emerging risk factor for cardiovascular disease?Withholding ACEIs unwarranted in mild renal insufficiencyTraditional Risk Factors and Newly Recognized Emerging Risk Factors for Cardiovascular Disease 17 April 2001Volume 134, Issue 8Page: 707-709KeywordsAngiotensin converting enzyme inhibitorAttentionBlood pressureCardiovascular disease riskCardiovascular diseasesCreatinineHypertensionMedical risk factorsMicroalbuminuriaRenal diseases ePublished: 17 April 2001 Issue Published: 17 April 2001 CopyrightCopyright © 2001 by American College of Physicians. 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