tbuckley/cabot-search huggingface dataset:
Biomechanics of hitting: Basic use of the arm in Tennis
Authors: Suzan Livingstone
Journal: British Journal of Sports Medicine (1972)

67 bound to recur unless the thrower changes his style completely, and uses extension of the elbow instead of medial rotation of the shoulder.These coaching points will be discussed in more detail, and with a great deal more authority, in the paper below by Colin Smith.(Fig. 4.)Inertia effect ofann PhilJavelin Strut on
Acute myelogenous leukemia associated with extreme symptomatic thrombocytosis and chromosome 3q translocation: Case report and review of literature
Authors: Victor T. Chang, Hana Aviv, Leslie M. Howard, Frank Padberg
Journal: American Journal of Hematology (2002)

Abstract Acute leukemias with thrombocytosis have been recently linked with structural abnormalities of the short arm of chromosome 3. A 46‐year‐old man with a 2‐month history of recurrent transient ischemic attacks and abdominal pain developed an ischemic left foot and a gangrenous toe as his initial symptoms. Platelet count was 3.5 × 10 6 /μL, and despite plateletpheresis, the patient required left‐leg amputation. Pathologic examination was remarkable for arterial thrombosis in the absence of atherosclerotic lesions. A diagnosis of acute myeloid leukemia with a novel translocation between chromosomes 3q21, 16, and 7 was made. Induction therapy was unsuccessful, and the patient died of overwhelming sepsis within 5 weeks of diagnosis. The striking features of this case were extreme symptomatic thrombocytosis, peripheral gangrene without atherosclerosis, and a novel three‐way chromosomal translocation involving chromosome 3q21. Am. J. Hematol. 72:20–26, 2003. © 2002 Wiley‐Liss, Inc.
Pigmented reticular structures in basal cell carcinoma and collision tumours
Authors: A. Gulia, D. Altamura, S. De Trane, T. Micantonio, M.C. Fargnoli, K. Peris
Journal: British Journal of Dermatology (2009)

The dermatoscopic diagnosis of basal cell carcinoma (BCC) is based on well-known specific criteria. Despite the fact that a pigment network is considered a negative feature for the diagnosis of BCC, its detection in a BCC context has been reported in 2.8% of cases.To determine whether pigment networks or network-like structures might represent a pitfall for the correct diagnosis of BCC.Dermatoscopic images of 412 histopathologically proven BCCs were analysed retrospectively.Pigment network or network-like structures were detected in 14 of 412 (3.4%) BCCs. Nine of 14 BCCs presented a typical pigment network, due to the association of a BCC lesion with a naevus, solar lentigo or actinic keratosis; two BCCs located on the face showed a pseudonetwork, and three of 14 lesions displayed a network-like structure characterized by light-brown irregularly meshed short linear structures, histopathologically related to a hyperpigmentation of the basal layer of the epidermis.The presence of a pigment network in the context of a BCC is uncommon, and it usually reflects the association of BCC with a solar lentigo, naevus or a specific location of the lesion on photodamaged skin.
Hyperphosphatemia and Hypocalcemia in Myeloproliferative Disorder
Authors: KAMEL AJLOUNI
Journal: Annals of Internal Medicine (1974)

Letters1 July 1974Hyperphosphatemia and Hypocalcemia in Myeloproliferative DisorderKAMEL AJLOUNI, M.D., WILLIAM L. MILLMAN, M.D., JOSEPH A. LIBNOCH, M.D., GEORGE B. THEIL, M.D., F.A.C.P.KAMEL AJLOUNI, M.D.Search for more papers by this author, WILLIAM L. MILLMAN, M.D.Search for more papers by this author, JOSEPH A. LIBNOCH, M.D.Search for more papers by this author, GEORGE B. THEIL, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-81-1-119 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Recent reports of hyperphosphatemia and hypocalcemia as a complication of antileukemic therapy in children (1-3) have prompted us to report this occurrence in a 33-year-old man with an acute myeloproliferative disorder.He presented initially with severe hypercalcemia, which required repeated courses of mithramycin therapy until the hematological disorder was diagnosed. Prednisone therapy was then started in a dose of 120 mg per day, which had no effect on the serum calcium or phosphorus concentrations. After 3 days of prednisone therapy, thioguanine (25 mg/kg body weight) and cytosine arabinoside (3.0 mg/kg body weight) were added. Sixteen hours later...References1. ZUSMAN J, BROWN D, and NESBIT M: Hyperphosphatemia, hyperphosphaturia and hypocalcemia in acute lymphoblastic leukemia. N Engl J Med 289:1335-1340, 1973 CrossrefMedlineGoogle Scholar2. JAFFE N, PAED D, and KIM B: Hypocalcemia—a complication of childhood leukemia. Cancer 29:392-398, 1972 CrossrefMedlineGoogle Scholar3. CLARKSON D, BLONDIN J, and CRYER P: Phosphate depletion and glucocorticoid-induced hyperphosphatemia in lymphoblastic leukemia. Metabolism 22:611-616, 1973 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: KAMEL AJLOUNI, M.D.; WILLIAM L. MILLMAN, M.D.; JOSEPH A. LIBNOCH, M.D.; GEORGE B. THEIL, M.D., F.A.C.P.Affiliations: Departments of Medicine Veterans Administration Center Wood, Wisconsin, and The Medical College of Wisconsin Milwaukee, Wisconsin PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byA Hospital Survey of Hypocalcemia in Patients with Malignant DiseaseAcute myelofibrosis and malignant hypercalcemia 1 July 1974Volume 81, Issue 1Page: 119-120KeywordsBody weightCalciumChildrenCytosineHematology and oncologyHypercalcemiaHypocalcemiaMyeloproliferative disordersPhosphorusThioguanine ePublished: 1 December 2008 Issue Published: 1 July 1974 PDF downloadLoading ...
Junior doctors' shifts and sleep deprivation: “Weeks of nights” give the illusion of working fewer hours
Authors: Arvindan Veiraiah
Journal: BMJ (2005)

Junior doctors' shifts and sleep deprivation New on-call rotas do not workEditor-Clearly the editorial by Murray et al on junior doctors' shifts has struck a chord with many, as on-call rotas are something close to many doctors hearts. 1 2 To most it seems the grass is not greener on the other side.Having worked most rotas, be it a traditional one in four, with full weekends, to partial, hybrid, and full shift patterns, I am in a reasonable position to comment on what I think makes a liveable on-call rota.I was under the impression that the European Working Time Directive was set out to improve the health and safety of workers, make working conditions better, but also make life away from work better because doctors would be less tired.The directive scores a "no" against all of these.I find myself more tired at work and at home, less enthusiastic, and less motivated by what is becoming a regular chore.Instead of being on call once a week, I find myself doing an on-call shift two or three times a week (on average), being late home more often than not because fewer juniors are around, and spending less time with my young children.The "old" rota system of a 24 hour oncall, with at least six on a rota, made on-call shifts less frequent, more tolerable, and even enjoyable.It also left plenty of time for training, and so long as there were six or more on rota, it made the annual leave far more flexible and workable.Anaesthetists rarely complained, certainly compared with other specialties' rotas, and everyone knew that however busy, you were always going to go home to a full day off in the morning.Why not listen to those doing the rota, and affected family members, and respect within reason what the workers want to work.
Bronchial lavage in status asthmaticus.
Authors: P. E. Walker, M. Marshall
Journal: BMJ (1969)

necessitated withdrawal of the drug after only 350 mg. had been given.The blood urea returned to normal in a few days but the patient then developed an acute meningitis which was probably simply an exacerbation of the torulosis.Fortunately at this time a supply of 5-fluorocytosine became available.
β‐thromboglobulin in patents with breast cancer
Authors: J. P. Ferriere, D. Bernard, M. Legros, J. Chassagne, P. Chollet, G. Gaillard, R. Plagne
Journal: American Journal of Hematology (1985)

Abstract β‐thromboglobulin (βTG) plasma levels were determined in 52 female breast cancer patients at different stages and in 39 healthy controls (22 women and 17 men) of similar age distribution. βTG levels were high (mean ± SD: 61.6 ± 59.1 ng/ml) in patients before any treatment compared to controls (mean ± SD: 21.2 ± 7.4 ng/ml) and the difference was statistically significant (p &lt; 0.001). No correlation with disease stage was observed. No other coagulation parameters were abnormal except fibrinogen, which increased. Fibrinogen degradation products (FDP) also increased but only in metastatic patients. Chemotherapy appeared to induce a considerable decrease in initial values at the end of the first cycle without modifying the platelet count. In addition, an attempt was made to correlate the βTG plasma level investigated serially for several months with disease evolution.
High adherence to HIV prophylaxis reduces chances of infection from partner, research finds
Authors: Z. Kmietowicz
Journal: BMJ (2013)

Taking more action to ensure people take their tablets may be the key to improving the success of pre-exposure prophylaxis (PrEP), researchers have said.

In a trial in Uganda, the researchers found that a high level of adherence to PrEP gave 100% protection against HIV infection over an average of 11 months to heterosexuals who had an HIV positive partner.1

Several previous randomised controlled trials in various populations have reported levels of protection against HIV infection from PrEP of between 0% and 75%. One possible …
Changes in the electrolyte content of leucocytes at different clinical stages of cirrhosis.
Authors: A N Alam, P Wheeler, S P Wilkinson, L Poston, C Golindano, R Williamss
Journal: Gut (1978)

The intracellular sodium, potassium, and water content of isolated leucocytes was estimated in 47 patients with cirrhosis. The values for sodium showed a wide scatter. In patients without ascites the mean value was significantly increased but in those accumulating ascites it was normal, although often reduced in individual subjects. Reduced values were found in patients with hyponatraemia associated with end-stage cirrhosis and diuretic treatment. Changes in leucocyte water content closely followed those in sodium content. Leucocyte potassium content was normal except in patients accumulating ascites in whom it was significantly reduced, indicating whole body depletion, and this could be corrected by administration of spironolactone.
EBERTHELLA TYPHOSA INFECTION OF ARTERIOVENOUS ANEURYSM CURED BY EXCISION
Authors: CHARLES L. HUDSON
Journal: JAMA (1949)

A case of acquired arteriovenous aneurysm infected by Eberthella typhosa, weakened to the point of rupture and cured by surgical intervention is reported because of its interest and rarity. Although this is the fourth case of infected arteriovenous aneurysm reported in the literature as cured by surgical means, it is the only one in which E. typhosa was the infecting organism. The case history, physical observations, pathologic report, treatment and sequelae are reported herewith.  REPORT OF CASE  History and Preoperative Data.—  P. M., a man aged 30, was admitted to Lakeside Hospital by one of us (C. L. H.), on Nov. 14, 1947 for a febrile illness which clinically and with laboratory examination proved to be typhoid. On physical examination striking but unrelated observations were a loud continuous hum heard on the left over the upper portion of the chest and axilla, a thrill felt in the left subclavicular and
Clinical and Biological Evaluation of Semi‐Rush and Ordinary Immunotherapy Schemes in Type I Allergic Respiratory Diseases
Authors: W. J. Stevens, J. A. Verhelst, W. van den Bogaert, C. H. Bridts
Journal: Allergy (1985)

Forty‐three patients with type I allergic respiratory diseases received aqueous grass pollen immunotherapy in a prospective study designed to compare the clinical and biological effects of a semi‐rush hyposensitization (20 patients) with ordinary hyposensitization (23 patients). Before the start of the therapy (end of previous grass pollen season, tl) and before (t2) and after the next grass pollen season (t3), total serum IgE (tIgE), grass pollen‐specific IgE (GPsIgE), grass pollen‐specific IgG (GPsIgG) and complement factors C3 and C4 were determined. GPsIgE and GPsIgG levels increased significantly more during immunotherapy in patients receiving the semi‐rush scheme as compared with the ordinary scheme. There were no significant changes between the two schemes at any times for tIgE, C3 and C4. GPsIgG was already higher in allergic patients before the start of therapy as compared with non‐allergic patients and controls. Clinical improvement was the same in patients treated with the semi‐rush scheme as in the ordinary group. The number of side effects was not statistically different between the two groups. In neither group was there a correlation between the change in biological parameters and change in clinical symptoms. As the semi‐rush scheme gives the same results immunologically as well as clinically, it could be used in a number of patients since it reduces the time course of the initial therapy by about 2 months.
Therapeutic activity of multiple common γ-chain cytokine inhibition in acute and chronic GVHD
Authors: Anne-Kathrin Hechinger, Benjamin A. H. Smith, Ryan Flynn, Kathrin Hanke, Cameron McDonald-Hyman, Patricia A. Taylor, Dietmar Pfeifer, Björn Hackanson, Franziska Leonhardt, Gabriele Prinz, Heide Dierbach, Annette Schmitt-Graeff, Jiri Kovarik, Bruce R. Blazar, Robert Zeiser
Journal: Blood (2014)
Diuretic Drug Use and the Risk for Hip Fracture
Authors: Fred E. Heidrich
Journal: Annals of Internal Medicine (1991)

Objective: To test the hypothesis that use of thiazide diuretics prevents hip fracture and to study the risk for hip fracture associated with furosemide use. Design: A case-control study. Setting: Hospitals owned by a health maintenance organization in Washington. Patients: Elderly patients (n = 462) hospitalized because of a hip fracture between 1977 and 1983 and an equal number of age- and sex-matched population-based control patients. Measurements: Use of thiazide diuretics and furosemide was ascertained from medical records and computerized pharmacy records. The relative risk for hip fracture associated with diuretic use was calculated and adjusted for the potentially confounding effects of nursing home residence; previous hospitalizations; a history of stroke, alcoholism, or the organic brain syndrome; body weight; leg paralysis; and use of phenobarbital, corticosteroids, or other diuretics. Current and former users of diuretics were analyzed separately. Main Results: The adjusted risk for hip fracture was 1.6 (95% Cl, 1.0 to 2.5) for current thiazide users. The adjusted risk for hip fracture for current furosemide use was 3.9 (Cl, 1.5 to 10.4). Conclusions: According to this study, use of thiazide diuretics did not protect against hip fracture and cannot be recommended for fracture prevention. Current furosemide use was also associated with hip fracture.
NOAH WEBSTER AS EPIDEMIOLOGIST
Authors: ALDRED SCOTT WARTHIN
Journal: JAMA (1923)

Oct. 16, 1758, there was born, in the best front room of a farmhouse, in the primitive farming village of West Hartford, Conn., a male infant destined to play a very important part in the intellectual development of "these United States of America." Noah Webster is known today, by name, to every high school student in this land, because no American High School is without a copy of "Webster's D i c tionary." But he is known by name alone as the "great lexicographer and philologist," and even his legitimate posterity, as a class, the pedagogues, accord him in their minds no higher place than that of a compiler of a dictionary. Yet Webster might well, nay, should, be ranged with the Fathers of this nation, since perhaps no other single individual of Revolutionary times contributed more to the welding of the diverse colonial states into a national
Physician Orators of Boston
Authors: James F. Ballard
Journal: New England Journal of Medicine (1952)

THE Boston Massacre occurred in 1770 and it became the custom of the Town to commemorate the event by having a distinguished person deliver an oration on March 3 of each year. The first fifteen orations concerned this famous event. In 1783 the anniversary of the massacre was abolished, and Independence Day was officially designated as the Fourth of July, after which orations were delivered on this anniversary. An interesting book on the various orators was written in 1854 by James Spear Loring.† Many noted Boston physicians, from the beginning, delivered a number of the commemorative addresses.The first, in . . .
The Diagnosis of Coronary Artery Disease in Hypertensive Patients with Chest Pain and Complete Left Bundle Branch Block
Authors: MAURO FEOLA, ALBERTO BIGGI, FLAVIO RIBICHINI, GIANFRANCO CAMUZZINI, EUGENIO USLENGHI
Journal: Clinical Nuclear Medicine (2002)

Purpose Hypertensive patients with complete left bundle branch block who experience chest pain present special problems in the radionuclide diagnosis of coronary artery disease (CAD). The aim of this study was to assess the utility of Tc-99m tetrofosmin SPECT for the diagnosis of CAD in 35 hypertensive patients with left bundle branch block hospitalized for chest pain. Materials and Methods Images were analyzed semiquantitatively for the presence of both fixed or reversible perfusion defects (method A) or only reversible defects (method B) in the distribution of the left anterior descending artery (LAD) territory. Perfusion defects observed in the territory of any other coronary artery were always considered. Thirty-five patients without infarction underwent adenosine Tc-99m tetrofosmin SPECT, transthoracic echocardiography, and coronary angiography. Results The mean left ventricular ejection fraction was calculated as 39.9% ± 11.6%, and the prevalence of CAD was 29%. The sensitivity of SPECT was identical for the two methods at 89%. The specificity increased 19% with method A and 54% with method B. The positive predictive value remained unsatisfactorily low with both methods (27% for method A and 40% for method B), and the negative predictive value improved from 83% with method A to 93% with method B. Conclusions Only reversible perfusion defects in the LAD territory should be considered significant for CAD, and these patients should undergo coronary angiography. Reversible or fixed perfusion defects in the left circumflex and right coronary artery territories should be evaluated according to other clinical parameters (global left ventricular ejection fraction, extension of perfusion defects). The highly negative predictive value of adenosine SPECT could help in the exclusion of CAD.
Abstract 92: Comparative expression analysis of somatostatin receptor subtypes in human neuroendocrine tumors using two sets of new monoclonal antibodies.
Authors: Chiara Lambertini, Patrizia Barzaghi-Rinaudo, Lisa D'Amato, Stefan Schulz, Paolo Nuciforo, Herbert A. Schmid
Journal: Cancer Research (2013)

Abstract The expression and reliable detection of somatostatin receptor subtypes (SSTR1-5) is a prerequisite for the successful use of somatostatin analogues in neuroendocrine tumors (NET). Two sets of monoclonal antibodies (mAbs) against human SSTR1, 2A, 3 and 5 have recently been developed by two independent laboratories using rabbit and mouse hybridomas. Our aim was to evaluate the usefulness of both sets of mAbs for detection of SSTRs in NET samples as they are routinely collected in clinical practice. Mouse and rabbit mAbs were characterized in SSTR1, 2, 3 and 5-transfected HEK293 cells and human archival pancreatic tissue and NET samples. Comparative analysis of mAbs was also conducted by immunostaining of a tissue microarray composed of 75 cores of NET. Immunohistochemical analysis of HEK293 cells showed that both rabbit and mouse mAbs specifically detect their cognate receptor subtype, with mild cytoplasmic cross-reactivity observed for rabbit mAbs. Both sets of mAbs labeled normal pancreatic islets and showed similar patterns of immunoreactivity in NET controls. Direct comparison of mAb sets using a NET tissue microarray revealed a strong correlation between rabbit and mouse mAbs against SSTR1 and 5, and moderate correlation for SSTR3. The rabbit mAb against SSTR2A showed higher affinity for its cognate receptor than the corresponding mouse mAb, resulting in more reliable detection of this SSTR. In conclusion, mAbs from both sets are reliable tools for the detection of SSTR1, 3 and 5, whereas the rabbit mAb against SSTR2A is recommended for use in routine clinical testing due to its superior binding affinity. Citation Format: Chiara Lambertini, Patrizia Barzaghi-Rinaudo, Lisa D'Amato, Stefan Schulz, Paolo Nuciforo, Herbert A. Schmid. Comparative expression analysis of somatostatin receptor subtypes in human neuroendocrine tumors using two sets of new monoclonal antibodies. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 92. doi:10.1158/1538-7445.AM2013-92
Cardioprotective Effect of Prior β-Blocker Therapy in Reducing Creatine Kinase-MB Elevation After Coronary Intervention
Authors: Samin K. Sharma, Annapoorna Kini, Jonathan D. Marmur, Valentin Fuster
Journal: Circulation (2000)

Background —Both retrospective studies and prospective randomized trials have shown that β-blockers improve survival and reduce the risk of reinfarction in patients with myocardial infarction. To evaluate whether β-blockers exert similar protective benefits during and after coronary intervention, we studied the incidence of postprocedure creatine kinase (CK)-MB elevation in patients with or without prior β-blocker therapy and its effect on intermediate-term (≈1 year) survival. Methods and Results —We prospectively analyzed 1675 consecutive patients undergoing coronary intervention; of these patients, 643 (38.4%) were on β-blocker therapy before the intervention. The incidence of CK-MB elevation after coronary intervention was 13.2% in patients on β-blocker therapy before intervention and 22.1% in patients who were not on β-blockers ( P &lt;0.001). Patients with prior β-blocker therapy had lower persistent/recurrent postprocedure chest pain and lower preprocedure and postprocedure heart rates and mean blood pressures compared with patients who were not on β-blockers ( P &lt;0.001). Multiple linear regression analysis revealed prior β-blocker therapy as the sole independent factor for lower CK-MB release after coronary intervention. During intermediate-term follow-up at 15±3 months, patients on β-blocker therapy before intervention had lower mortality rates compared with those not on β-blockers (0.78% versus 1.96%; P =0.04), although the benefit was independent of the reduction in CK-MB release. Conclusions —Our nonrandomized, prospective analysis suggests that prior β-blocker therapy has a cardioprotective effect in limiting CK-MB release after coronary intervention and that it is associated with a lower mortality at intermediate-term follow-up.