tbuckley/cabot-search huggingface dataset:
Current Therapy of Gonorrhea
Authors: Joseph G. Caldwell
Journal: JAMA (1971)

Dr. Steven Raffin, Senior Assistant Resident in Medicine, the Jewish Hospital of St. Louis and Assistant in Medicine, Washington University School of Medicine: A 27-year-old woman was hospitalized with acute migratory polyarthritis of four days' duration. She had noted the abrupt onset of right wrist stiffness, followed by swelling and erythema of the right elbow, left fourth and fifth metacarpophalangeal joints, right shoulder, left elbow, and both knees. Four days prior to these symptoms, she had noted a profuse, white vaginal discharge. One day before entry, pustules surrounded by erythema had appeared over the medial base of both thumbs. Her only medication at the time of admission consisted of oral contraceptive tablets. Twice previously, she had been treated for gonorrhea, most recently six months before.  On physical examination, the patient was anxious but not severely ill. The blood pressure was 100/70 Hg; pulse rate, 100 beats per minute and regular;
Huntingtin Is Required for Mitotic Spindle Orientation and Mammalian Neurogenesis
Authors: Juliette D. Godin, Kelly Colombo, Maria Molina-Calavita, Guy Keryer, Diana Zala, Bénédicte C. Charrin, Paula Dietrich, Marie-Laure Volvert, François Guillemot, Ioannis Dragatsis, Yohanns Bellaiche, Frédéric Saudou, Laurent Nguyen, Sandrine Humbert
Journal: Neuron (2010)
TCT-498 Safety and performance of the next generation EnligHTN(tm) Renal Denervation System in patients with drug-resistant, uncontrolled hypertension: a first-in-human multicentre study
Authors: Stephen Worthley, Gerry Wilkins, Mark W. Webster, Paul Antonis, Roderic Warren, Robert J. Whitbourn
Journal: Journal of the American College of Cardiology (2013)
BMA warns against any extension of "zero hours" contracts in NHS
Authors: N. Hawkes
Journal: BMJ (2012)

The public service union Unison has claimed that the growth of “zero hours” contracts in the NHS risks damaging patient care. The union believes that such contracts, which are already fairly common among lower paid workers, are increasing among the more highly qualified and people with clinical roles as a direct result of the coalition government’s reorganisation of the healthcare system.

Zero hours contracts, sometimes called “as and when” contracts, do not commit those people who sign them to any set hours or guarantee them any pay. But they provide hospitals with a pool of experienced staff who can be called on at times of increased demand and give individuals a …
Renal Reabsorption of Phosphate in Normal Human Subjects and in Patients with Parathyroid Disease
Authors: David D. Thompson, Howard H. Hiatt
Journal: Journal of Clinical Investigation (1957)

A number of studies in the dog and in man (1-6) have demonstrated a maximal renal tubu- lar reabsorptive capacity for phosphate (TmP 8).However, some investigators have denied that the reabsorption of phosphate conforms to Tm charac- teristics (7-9).These workers have suggested that phosphate reabsorption is conditioned by the rate of phosphate filtration such that a fairly constant proportion of the filtered phosphate is reab- sorbed.In view of the conflicting evidence and the relative paucity of phosphate titration studies on man, experiments were performed in order to obtain information on the mechanism of phosphate reabsorption, the constancy of reabsorption in any one individual, and its variability in a group of subjects.The data were required for subsequent investigations designed to evaluate the influence of several factors on renal phosphate transport.The studies were performed on normal individuals and in patients with parathyroid disease.It was found that in any given experiment a TmP was demonstrable.However, the variability in TmP seen in most of our normal subjects be- tween consecutive periods of a single experiment and between experiments generally exceeded the variability reported for glucose Tm and for PAH Tm.Furthermore, the range of values for TmP within a group of normal individuals is so large that an average value has little meaning.
Lithium fluxes across the gastric mucosa after truncal vagotomy and drainage--an objective assessment of mucosal injury.
Authors: M J Gough, L Woodhouse, G R Giles
Journal: Gut (1986)

Gastric mucosal permeability to lithium has been measured in 20 patients with an untreated duodenal ulcer, eight patients who were asymptomatic for more than one year after truncal vagotomy and drainage, 14 patients with an endoscopically proven recurrent ulcer, and 21 patients with an unsatisfactory result from truncal vagotomy and drainage for other reasons. Lithium fluxes were lowest in the asymptomatic postoperative patients (0.149 +/- 0.028 mmol Li+/15 min), but were not significantly different to the measured fluxes in patients with a duodenal ulcer before treatment (0.160 +/- 0.020 mmol Li+/15 min) or a recurrent ulcer after truncal vagotomy and drainage (0.169 +/- 0.022 mmol Li+/15 min) (SEM). By comparison the mean lithium flux in patients who were dissatisfied with the results of their previous surgery for reasons other than a recurrent ulcer (0.234 +/- 0.019 mmol Li+/15 min) was significantly higher than that observed in patients with a duodenal ulcer (p less than 0.05), patients with a recurrent ulcer (p less than 0.05) or patients who were asymptomatic after definitive ulcer surgery (p less than 0.02). Furthermore, when the lithium fluxes observed in 11 patients whose major postoperative complaint was bile vomiting (0.243 +/- 0.027 mmol Li+/15 min) were compared with results from the remaining 52 patients included in the study (0.173 +/- 0.012 mmol Li+/15 min) fluxes were significantly higher in the 9bile vomiters9 (p less than 0.05).
Abstract 2154: Notoginseng suppresses azoxymethane/dextran sulphate sodium-induced colitis and colitis-associated colorectal carcinogenesis
Authors: Chong-Zhi Wang, Chun-Su Yuan
Journal: Cancer Research (2014)

Abstract Colorectal cancer remains one of the most prevalent cancers and a leading cause of cancer related death in the US. Many currently used chemotherapeutic agents are derived from botanicals. Identifying the herbal sources, including those from ginseng family, to develop better preventive or therapeutic agents remains an essential step in advancing the management of the cancer. Patients suffering from inflammatory bowel disease are at a high risk of developing colorectal cancer. To evaluate the anti-cancer potential of botanicals, we evaluated the effects of notoginseng on azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced colitis. One week after A/J mice received AOM, the animals received DSS for 8 days, or were supplemented with notoginseng extract, at 30 or 90 mg/kg. DSS-induced colitis was scored with the disease activity index (DAI). The severity of the inflammatory lesions was evaluated by a colon tissue histological assessment. The expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) were also investigated. We observed that the effects of notoginseng on the reduction of colon inflammation, expressed in the DAI score, were in a dose-related manner (p &amp;lt; 0.01). Notoginseng inhibited the reduction of colon length and loss of bodyweight in a dose-related manner (all p &amp;lt; 0.05). The histological assessment of colitis and the inflammatory related immunohistochemical data of iNOS and COX-2 also supported the pharmacological observations. Our data suggest that notoginseng is a promising candidate in preventing and treating colitis and inflammation-associated colon carcinogenesis. (This work was supported in part by the NIH/NCCAM grants AT004418 and AT005362). Citation Format: Chong-Zhi Wang, Chun-Su Yuan. Notoginseng suppresses azoxymethane/dextran sulphate sodium-induced colitis and colitis-associated colorectal carcinogenesis. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2154. doi:10.1158/1538-7445.AM2014-2154
Erratum: Corrigendum: Structural basis for modulation of Kv4 K+ channels by auxiliary KChIP subunits
Authors: Huayi Wang, Yan Yan, Qun Liu, Yanhua Huang, Yue Shen, Linjie Chen, Yi Chen, Qiuyue Yang, Quan Hao, KeWei Wang, Jijie Chai
Journal: Nature Neuroscience (2007)
UK government invites bids for general practices in supermarkets
Authors: Michael Day
Journal: BMJ (2007)

Supermarkets could house new NHS general practices, under government plans to boost access to primary care in some of the United Kingdom's most deprived areas.

The health secretary, Patricia Hewitt, said that Hartlepool, County Durham, Ashfield, and Great Yarmouth will be the first areas to gain extra family practices, walk-in centres, and minor injuries units located in private businesses.

Private health firms, GPs, and social enterprises will be free to bid for the contracts with primary care trusts (PCTs), which could include early morning, evening, and weekend clinics, under the “fairness in primary care” procurement programme. Contracts …
Homosexuality and Prostitution
Authors: D. M. Odlum
Journal: BMJ (1956)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following Homosexuality and Prostitution Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Acute stridor in a preschool child
Authors: J L Emery, E. M Taylor
Journal: BMJ (1984)

<h3>Objective</h3> To conduct a comprehensive analysis of circulating metabolites and incident stroke in large prospective population-based settings. <h3>Methods</h3> We investigated the association of metabolites with risk of stroke in 7 prospective cohort studies including 1,791 incident stroke events among 38,797 participants in whom circulating metabolites were measured by nuclear magnetic resonance technology. The relationship between metabolites and stroke was assessed with Cox proportional hazards regression models. The analyses were performed considering all incident stroke events and ischemic and hemorrhagic events separately. <h3>Results</h3> The analyses revealed 10 significant metabolite associations. Amino acid histidine (hazard ratio [HR] per SD 0.90, 95% confidence interval [CI] 0.85, 0.94; <i>p</i> = 4.45 × 10<sup>−5</sup>), glycolysis-related metabolite pyruvate (HR per SD 1.09, 95% CI 1.04, 1.14; <i>p</i> = 7.45 × 10<sup>−4</sup>), acute-phase reaction marker glycoprotein acetyls (HR per SD 1.09, 95% CI 1.03, 1.15; <i>p</i> = 1.27 × 10<sup>−3</sup>), cholesterol in high-density lipoprotein (HDL) 2, and several other lipoprotein particles were associated with risk of stroke. When focused on incident ischemic stroke, a significant association was observed with phenylalanine (HR per SD 1.12, 95% CI 1.05, 1.19; <i>p</i> = 4.13 × 10<sup>−4</sup>) and total and free cholesterol in large HDL particles. <h3>Conclusions</h3> We found association of amino acids, glycolysis-related metabolites, acute-phase reaction markers, and several lipoprotein subfractions with the risk of stroke. These findings support the potential of metabolomics to provide new insights into the metabolic changes preceding stroke.
A synthetic fibrin cross-linking polymer for modulating clot properties and inducing hemostasis
Authors: Leslie W. Chan, Xu Wang, Hua Wei, Lilo D. Pozzo, Nathan J. White, Suzie H. Pun
Journal: Science Translational Medicine (2015)

By cross-linking fibrin, intravenously injected factor XIII–inspired hemostatic polymers stabilize clots and reduce bleeding in a rat model of trauma and fluid resuscitation.
IL-9 and its receptor in allergic and nonallergic lung disease: Increased expression in asthma
Authors: Ayako Shimbara, Pota Christodoulopoulos, Abdelilah Soussi-Gounni, Ronald Olivenstein, Yutaka Nakamura, Roy C. Levitt, Nicholas C. Nicolaides, Kenneth J. Holroyd, Anne Tsicopoulos, Jean-Jacques Lafitte, Benoit Wallaert, Qutayba A. Hamid
Journal: Journal of Allergy and Clinical Immunology (2000)
Gene Linked to Skin Disorder
Authors: Joan Stephenson
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bacterial lipopolysaccharide enhances aflatoxin B1 hepatotoxicity in rats by a mechanism that depends on tumor necrosis factor α
Authors: Charles C. Barton, Eva X. Barton, Patricia E. Ganey, Steven L. Kunkel, Robert A. Roth
Journal: Hepatology (2001)

Exposure to a nontoxic dose of bacterial endotoxin (lipopolysaccharide [LPS]) potentiates the hepatotoxicity of aflatoxin B(1) (AFB(1)). Because some of the pathophysiologic effects associated with LPS are mediated through tumor necrosis factor alpha (TNF-alpha), this study was conducted to explore the role of TNF-alpha in the AFB(1)/LPS model. Male Sprague-Dawley rats (250-300 g) were treated with either 1 mg AFB(1)/kg, intraperitoneally, or its vehicle (0.5% dimethyl sulfoxide [DMSO]/water), and 4 hours later with either Escherichia coli lipopolysaccharide (7.4 x 10(6)EU/kg, intravenously) or its saline vehicle. LPS administration resulted in a marked rise in TNF-alpha levels at 6 hours, which preceded the onset of liver injury. TNF-alpha messenger RNA (mRNA) in liver was increased by LPS treatment. The mRNA of receptors (R1 and R2) for TNF-alpha was also examined. R1 mRNA levels were not altered; however, R2 mRNA levels were increased by either AFB(1) or LPS administration. To determine if TNF-alpha plays a causal role in the development of liver injury, the increase in TNF-alpha was attenuated by administration of either pentoxifylline or anti-TNF-alpha serum, and liver injury was assessed. Administration of either of these agents resulted in protection. LPS treatment resulted in the upregulation of gene transcription for cyclooxygenase-2 (COX-2). However, administration of the selective COX-2 inhibitor NS-398 did not decrease injury. TNF-alpha and COX-2 inhibitors did not affect hepatic sequestration of neutrophils. Furthermore, it did not appear that TNF-alpha contributed to injury through inhibition of tissue repair. These data support the hypothesis that LPS-induced expression of TNF-alpha underlies the potentiation of AFB(1)-induced hepatotoxicity.
Medical leeches as sources of wound infection.
Authors: N S Mercer, D M Beere, A J Bornemisza, P Thomas
Journal: BMJ (1987)

CommentOur data contrast with those of Dow et aP in that they suggest that added testosterone is beneficial in alleviating psychosexual symptoms.One reason for the difference may be the selection process: Dow et al studied an unselected group of patients attending their menopause clinic while we chose patients in whom oral oestradiol had failed to relieve psychosexual symptoms.Perhaps only in this group is testosterone specifically effective.No significant side effects were experienced.We are grateful to Peter Dennis, Ken Outch, Nick Balazs, and Mohan Bangah for hormone and lipid assays, to Jill Volfsbergs for secretarial help, and to Robyn Redman for the artwork.Organon Australia
Vulvitis chronica plasmacellularis (Zoon's vulvitis)
Authors: G.M. KAVANAGH, P.A. BURTON, C.T.C. KENNEDY
Journal: British Journal of Dermatology (1993)

Summary Vulvitis chronica plasmacellularis (Zoon's vulvitis) is rare. We describe a case in whom all the typical features, as delineated by Zoon. are demonstrated.
Tumor Cells Expressing Anti-CD137 scFv Induce a Tumor-Destructive Environment
Authors: Yi Yang, Shilin Yang, Zhengmao Ye, Jade Jaffar, Yifeng Zhou, Erin Cutter, Andre Lieber, Ingegerd Hellström, Karl Erik Hellström
Journal: Cancer Research (2007)

Abstract For immunotherapy to become more effective, there is a need to maximize the antitumor response at the tumor site as well as to eliminate tumor cell variants that lack a given tumor antigen or the ability to present it. We have previously shown that wild-type (WT) cells from the K1735 melanoma (K1735-WT) are rejected following vaccination with cells (K1735-1D8) transfected to express scFv from the anti-CD137 monoclonal antibody 1D8, and that CD4+ T cells and natural killer (NK) cells are needed for this rejection. We now show that tumors harvested 4 to 10 days after mice had been transplanted with K1735-1D8 cells or a mixture of K1735-1D8 and K1735-WT cells contained more NK cells and that they had an increased percentage of CD4+ T lymphocytes producing IFNγ or tumor necrosis factor-α. We further show that the percentage of NK cells was higher in B16-1D8 melanomas expressing anti-CD137 scFv than in the WT tumors and that the percentage of FoxP3+ cells was lower. Admixture of 10% K1735-1D8 cells prevented the progressive growth of transplanted K1735-WT cells in syngeneic mice and also of cells from the antigenically different sarcoma Ag104. Inhibition of WT tumor cells by tumor cells transfected to express anti-CD137 scFv was shown also with the TC1 carcinoma and B16 melanoma. Furthermore, injection of an adenovirus vector, Ad-1D8, which encodes anti-CD137 scFv into established B16 melanomas, significantly prolonged the survival of tumor-bearing mice and could induce regression. Our data suggest that targeting of anti-CD137 scFv to tumors should be explored for therapy for some human cancers. [Cancer Res 2007;67(5):2339–44]
An Added Cost of Inflation and Recession
Authors: Louis E. Kopolow
Journal: JAMA (1976)

For a long time, epidemiologists have noted the correlation between certain physical ailments and socioeconomic factors, such as poverty, inadequate housing, malnutrition. An evolving corollary to this concept is the apparent relationship between the development and exacerbation of certain illnesses, especially mental illness, and a deterioration of the economic situation. The present economic recession and concomitant inflation are taking their toll on the mental and physical health of the nation. For the first time in their lives, millions of Americans are losing confidence in their ability to achieve a more prosperous future and even to maintain their present economic condition. The emotional climate in which people work and live has recently undergone considerable change, with the result that worrying about job security, bills, taxes, and skyrocketing costs of food and essential commodities has reached epidemic proportions. Recognizing this situation, it is not surprising to find that as the nation plunges
Office Computer Systems for Health Professionals: A Cost-Benefit Approach to Assessing Alternative Technologies
Authors: Bernhard A. Kats
Journal: JAMA (1991)

The medical office system is an automated office management system. Most vendors organize their software in modules. Typical applications are accounts receivable, appointment scheduling, word processing, and electronic claims processing. James W. Allen, MD, uses the step-by-step approach to outline cost-benefit analysis for assessment of office computer systems. Academic economic skills are not required, no hypotheses need to be formulated, and statistical treatments are kept simple. Medical office system purchases by physicians are often made intuitively, influenced in part by vendor pressure and word of mouth. This sometimes (frequently in the past) results in frustration, staff attrition, and loss of income. To approach the issues from a rational viewpoint, the author uses the "present value (PV) concept." This is based on the principle that time affects the value of money. The time factor is measured by the interest rate, called the discount rate. By comparing the cost of each medical
Naevus sebaceus on the female breast accompanied with a tubular apocrine adenoma and a syringocystadenoma papilliferum
Authors: N. Yamane, N. Kato, T. Yanagi, R. Osawa
Journal: British Journal of Dermatology (2007)

Conflicts of interest: none declared. Sir, Tubular apocrine adenoma (TAA) is a very rare sweat gland tumour, first described in 1972.1 It was proposed as an independent clinical entity consisting of a benign appendage tumour of apocrine origin often associated with naevus sebaceus (NS).2 It is commonly located on the face and scalp. We report an unusual case of NS on the breast, which was accompanied with a TAA and a syringocystadenoma papilliferum (SCAP). A 77‐year‐old Japanese woman presented with several cutaneous lesions on her left breast. Physical examination revealed the lesions to consist of light‐brown, slightly elevated, linearly arranged plaques, an ulcerated intracutaneous nodule, and a red pedunculated nodule. The light‐brown plaques had been present since birth. In the plaques, there were small bean‐sized papules and fingertip‐sized, slightly elevated macules, forming a 10 × 4 cm, gently curved lesion as a whole at the upper lateral side of the left breast (Fig. 1, shown by dotted line with thin arrows). Then, 5 months prior to her visit, an asymptomatic, 10‐mm diameter, intracutaneous nodule with central ulceration (Fig. 1, arrow), and a red, 25‐mm diameter, pedunculated nodule resembling a raspberry (Fig. 1, arrowhead) appeared.
Melanoma immunotherapy by targeted IL-2 depends on CD4+ T-cell help mediated by CD40/CD40L interaction
Authors: Holger N. Lode, Rong Xiang, Ursula Pertl, Elisabeth Förster, Stephen P. Schoenberger, Stephen D. Gillies, Ralph A. Reisfeld
Journal: Journal of Clinical Investigation (2000)

The induction of tumor-protective immunity against malignancies remains a major challenge in cancer immunotherapy. A novel, humanized anti-ganglioside-GD2–IL-2 immunocytokine (hu14.18–IL-2) induced CD8+ T cells to eradicate established pulmonary metastases of B78-D14 murine melanoma, in a process that required help by CD4+ T cells and was mediated by the CD40/CD40 ligand (CD40L) interaction. The anti-tumor effect was diminished in mice deficient in CD4+ T-cells. Three lines of evidence show that CD4+ T-cell help was mediated by CD40/CD40L interaction but not by endogenous IL-2 production. First, the hu14.18–IL-2–induced anti-tumor response is partially abrogated in C57BL/6J CD40L knockout (KO) mice in contrast to C57BL/6J IL-2 KO animals, in which the immunocytokine was completely effective. Second, partial abrogation of the anti-tumor effect is induced with anti-CD40L antibodies to the same extent as with CD4+ T-cell depletion. Third, a complete anti-tumor response induced by hu14.18–IL-2 can be reconstituted in C57BL/6J CD40L KO mice by simultaneous stimulation with an anti-CD40 mAb. These results suggest that help provided by CD4+ T cells via CD40/CD40L interactions in our tumor model is crucial for effective immunotherapy with an IL-2 immunocytokine.