Hemolytic Anemia Induced by Dapsone Transmitted Through Breast Milk
Authors: STEPHEN W. SANDERS
Journal: Annals of Internal Medicine (1982)

Brief Reports1 April 1982Hemolytic Anemia Induced by Dapsone Transmitted Through Breast MilkSTEPHEN W. SANDERS, Pharm.D., JOHN J. ZONE, M.D., RODGER L. FOLTZ, Ph.D., KEITH G. TOLMAN, M.D., DOUGLAS E. ROLLINS, M.D., Ph.D.STEPHEN W. SANDERS, Pharm.D., JOHN J. ZONE, M.D., RODGER L. FOLTZ, Ph.D., KEITH G. TOLMAN, M.D., DOUGLAS E. ROLLINS, M.D., Ph.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-96-4-465 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDapsone (4,4′-diaminodiphenyl sulphone) is used to treat several dermatologie disorders (1) including dermatitis herpetiformis. Due to the chronicity of dermatitis herpetiformis and its frequent onset from age 20 to 40 years, therapy with dapsone may coincide with pregnancy and lactation. We describe an infant who had significant serum concentrations of dapsone and its primary metabolite, monoacetyldapsone, after ingesting breast milk containing dapsone. Both the mother and infant had compensated hemolytic anemia.Dapsone and monoacetyldapsone were analyzed by high pressure liquid chromatography using a modification of the method of Carr and associates (2). Recrystallized 3,3′-diaminodiphenylsulfone (Pfaltz & Bauer, Inc., Stamford, Connecticut)...References1. KRUIZING E and HAMMINGA H. Treatment of dermatitis herpetiformis with diaminodiphenylsulfone. Dermatologica. 1953;106:386-94. Google Scholar2. CARR K, OATES J, NIES A, and WOOSLEY R. Simultaneous analysis of dapsone and monoacetyldapsone employing high performance liquid chromatography. A rapid method for determination of acetylator phenotype. Br J Clin Pharmacol. 1978;6:421-7. CrossrefMedlineGoogle Scholar3. WILSON J, BROWN R, and CHEREK D. Drug excretion in human breast milk: Principles, pharmcokinetics, and projected consequences. Clin Pharmacokinetics. 1980;5:1-66. CrossrefMedlineGoogle Scholar4. PETERS J, MURRAY J, GORDON G, and GELBER R. Dapsone in saliva and plasma of man. Pharmacology. 1981;22:162-71. CrossrefMedlineGoogle Scholar5. LAMMINTAUSTA K, KANGAS L, and LAMMINTAUSTA R. The pharmacokinetics of dapsone and acetylated dapsone in serum and saliva. Int J Clin Pharmacol Biopharmacol. 1979;17:159-63. MedlineGoogle Scholar6. RILEY R and LEVY L. Characteristics of the binding of dapsone and monoacetyldapsone by serum albumin. Proc Soc Exp Biol Med. 1973;142:1168-70. CrossrefMedlineGoogle Scholar7. ELLARD G, GAMMON P, SAVIN J, and TAN R. Dapsone acetylation in dermatitis herpetiformis. Br J Dermatol. 1974;90:441-4. CrossrefMedlineGoogle Scholar8. GLADER B and CONRAD M. Hemolysis by diphenylsulfones: Comparative effects of DDS and hydroxylamine-DDS. J Lab Clin Med. 1973;81:267-72. MedlineGoogle Scholar9. RASBRIDGE M and SCOTT G. The haemolytic action of dapsone: changes in the red-cell membrane. Br J Haematol. 1973;24:183-93. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: STEPHEN W. SANDERS, Pharm.D.; JOHN J. ZONE, M.D.; RODGER L. FOLTZ, Ph.D.; KEITH G. TOLMAN, M.D.; DOUGLAS E. ROLLINS, M.D., Ph.D.Affiliations: College of Pharmacy and College of Medicine University of Utah Salt Lake City, Utah. 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Part III: Antituberculars, Quinolones and Urinary GermicidesDermatitis herpetiformisDrugs in breast milkExcretion of chloroquine, dapsone and pyrimethamine in human milk.Drugs in lactationDermatitis herpetiformis: jejunal findings and skin response to gluten free diet.Drugs used in tuberculosis and leprosy 1 April 1982Volume 96, Issue 4Page: 465-466KeywordsBreast milkChromatographyHealth services researchHemolytic anemiaInfantsLactationMetabolitesPregnancyResearch grantsSalts ePublished: 1 December 2008 Issue Published: 1 April 1982 PDF downloadLoading ...