T Cells and B Cells in HBsAg-Positive Patients with Chronic Persistent Hepatitis and Asymptomatic Carriers
Authors: HIROAKI ISHIMARU
Journal: Annals of Internal Medicine (1976)

Letters1 April 1976T Cells and B Cells in HBsAg-Positive Patients with Chronic Persistent Hepatitis and Asymptomatic CarriersHIROAKI ISHIMARU, M.D., KENICHI ITO, M.D., JUN NAKAGAWA, M.D., MASAICHI FUKASE, M.D.HIROAKI ISHIMARU, M.D.Search for more papers by this author, KENICHI ITO, M.D.Search for more papers by this author, JUN NAKAGAWA, M.D.Search for more papers by this author, MASAICHI FUKASE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-84-4-444 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHuman lymphocytes in the peripheral blood that form rosettes spontaneously with sheep erythrocytes (E rosettes) are thymus-derived. Bone marrow-derived lymphocytes (B cells), can bind antigen-antibody-complement complex by using the presence of receptors for the third factor of complement on the cell surface (EAC cells).Wybran and Fudenberg (1) suggested several hypotheses to explain the mechanism of depressed E rosettes in viral diseases, namely, that [1] viruses sterically hinder the receptors for sheep erythrocytes or may turn off the synthesis of such receptors; [2] viruses alter the lymphocyte metabolism so that modifications of the lymphocyte membrane prevent rosette formation with sheep...References1. WYBRAN J and FUDENBERG H: Thymus-derived rosette-forming cells in various human disease states: cancer, lymphoma, bacterial and viral infections, and other diseases. J Clin Invest 52:1026-1032, 1973 CrossrefMedlineGoogle Scholar2. DEHORATIUS R, STRICKLAND R, and WILLIAMS R: T and B lymphocytes in acute and chronic hepatitis. Clin Immunol Immunopathol 2:353-360, 1974 CrossrefMedlineGoogle Scholar3. JONDAL M, HOLM G, and WIGZELL H: Surface markers on human and B-lymphocytes. 1. A large population of lymphocytes forming non-immune rosettes with sheep red blood cells. J Exp Med 136:207-215, 1972 CrossrefMedlineGoogle Scholar4. ITO K, NAKAGAWA J, and OKIMOTO Y: Chronic hepatitis—migration inhibition of leukocytes in the presence of Australia antigen (letter). N Engl J Med 286:1005, 1972 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: HIROAKI ISHIMARU, M.D.; KENICHI ITO, M.D.; JUN NAKAGAWA, M.D.; MASAICHI FUKASE, M.D.Affiliations: Department of Internal Medicine Kyoto University School of Medicine Kyoto Japan PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byActivated lymphocytes in the peripheral blood of asymptomatic HBsAg carriersPeripheral T-cell subsets in asymptomatic hepatitis B-virus carriersFibroblast interferon treatment of a patient with chronic active hepatitisPossible mechanisms of tissue injury in hepatitis B virus infectionPeripheral blood and liver tissue T and B lymphocytes and hepatitis B virus (HBV)Immune Mechanisms and the Action of Interferon in Chronic Hepatitis B Virus Infection 1 April 1976Volume 84, Issue 4Page: 444-445KeywordsAntigensBlood cellsBone marrow cellsCellsChronic hepatitisErythrocyte membraneHepatitis ELymphocytesT cellsViral diseases ePublished: 1 December 2008 Issue Published: 1 April 1976 PDF downloadLoading ...