tbuckley/cabot-search huggingface dataset:
Alveolar rhabdomyosarcoma involving the heart. An echocardiographic, angiographic and pathologic study.
Authors: G S Orsmond, L Knight, L P Dehner, D M Nicoloff, M Nesbitt, F B Bessinger
Journal: Circulation (1976)

A 12-year-old girl, who had had an above-knee amputation of the left leg for a soft tissue sarcoma six years prior to this admission, presented with syncope, angina, and signs of aortic stenosis. Echocardiography demonstrated a mass arising from the interventricular septum with obstruction of the left ventricular outflow tract and aortic valve. Cardiac catheterization and angiography confirmed these findings. At operation, a tumor was found involving the interventricular septum. Histologically, it was an alveolar rhabdomyosarcoma, and it appeared similar to the previous tumor. The patient was treated by partial surgical resection, cytotoxic drugs and localized radiation therapy and has been followed by serial echocardiography.
Implementation of an intensive risk‐stratified treatment protocol for children and adolescents with acute lymphoblastic leukemia in Lebanon
Authors: Samar Muwakkit, Carol Al‐Aridi, Ahmad Samra, Raya Saab, Rami A. Mahfouz, Chantal Farra, Sima Jeha, Miguel R. Abboud
Journal: American Journal of Hematology (2012)

With modern risk-adapted therapy, over 80% of children with acute lymphoblastic leukemia (ALL) in high-income countries (HICs) are cured. In countries with limited resources, however, therapy results for pediatric ALL are still not encouraging. We describe our experience in treating children with ALL using a risk-adapted protocol at a tertiary referral center in Lebanon. From May 2002 to August 2009, 111 consecutive patients 1-21 years of age with newly diagnosed ALL received the CCCL ALL protocol which was based on the St. Jude Children's Research Hospital Total XV Study. The median age at diagnosis was 5 years 5 months. The male to female ratio was 1.5. Forty-six patients received the intermediate-/high-risk arm and 65 received the low-risk arm. Only one patient (0.9%) died during induction therapy. Relapse occurred in 8 (7.2%) patients. Eight (7.2%) patients died, 4 of whom were in remission. The median follow-up of the patients was 38 months. The 5-year overall survival and event-free survival were and 88.5% (95% CI: 77.1-94.4) and 78.7% (95% CI: 69.8-88.4), respectively. Our results are comparable to those in HICs in spite of the limited resources and the relatively low socioeconomic status of the Lebanese population. Children treated on this protocol experienced significant toxicity necessitating expert supportive care, but benefited from improved cure rates and prolonged survival.
The novel histone deacetylase inhibitor, LBH589, induces expression of DNA damage response genes and apoptosis in Ph− acute lymphoblastic leukemia cells
Authors: Anna Scuto, Mark Kirschbaum, Claudia Kowolik, Leo Kretzner, Agnes Juhasz, Peter Atadja, Vinod Pullarkat, Ravi Bhatia, Stephen Forman, Yun Yen, Richard Jove
Journal: Blood (2008)
Things As They Are
Authors: John B. Dillon
Journal: JAMA (1964)

This discussion is not to praise anesthesiologists, nor to glorify anesthesia, nor is its purpose to criticize surgeons or surgery. Its purpose is to present a serious problem that has not been given adequate consideration except by anesthesiologists, that is, what is happening to anesthesia in the "scientific frenzy" of present day medicine. It is mandatory that interest be kindled in the mind of "medicine," and that this responsible group help to correct a deficiency in the practice of medicine of primary importance to physicians, and of even more importance to the patients they help. This is not the first time that the general problem has been mentioned inThe Journal.<sup>1-3</sup> If one gives serious thought to the philosophical concept of contributions to human welfare one inescapable conclusion is reached: The introduction and development of surgical anesthesia has been, next to the printing press, man's greatest contribution to the
Virus-free blood.
Authors: L R Baker, W R Cattell, F J Goodwin, F P Marsh, J M Ledingham, J Blagdon, W J Jenkins, A J Zuckerman
Journal: BMJ (1971)

<h3>Aim</h3> To analyse the long-term outcome of lacrimal bypass surgery with an angled extended Jones’ tube. <h3>Design</h3> Retrospective, non-comparative, non-interventional case series. <h3>Methods</h3> Seventy-one patients who underwent transcaruncular insertion of an angled extended Jones’ tube between 1995 and 2005 were followed up over a median period of 8.7 years (range 11 days–17 years). <h3>Main outcome measures</h3> Patency and anatomic position of the tube, type and time lapse of the complications and subjective relief of epiphora. <h3>Results</h3> Overall, complications occurred in 39% of the tubes (35/90) at a median of 25 days (range 3 days–6 years) after the insertion. The major complications, that is, tube displacement or obstruction, were observed in 31% (28/90), with an incidence rate of 8% per year. The minor complications, that is, conjunctival overgrowth or granuloma at the lateral end, were encountered in 8% (seven of 90). The 10-year tube survival rate was 60%, with complete relief of epiphora in 88% of the patients. <h3>Conclusions</h3> The long-term outcome with the angled extended Jones’ tube inserted transcaruncularly remains relatively good, with most of the complications occurring in the early postoperative period.
A case of rheumatoid meningitis positive for perinuclear antineutrophil cytoplasmic antibody
Authors: M FUNAUCHI
Journal: Annals of the Rheumatic Diseases (2000)

CoVee consumption, RF, and the risk of RAStress is one of the factors that can trigger the onset of rheumatoid arthritis (RA).People working under deadline pressure, and people characterised as hard driving, "type A" personalities may be most likely to experience stress.These are the same people who may consume large quantities of coVee in order to stay at peak performance for longer periods of time.Possibly, therefore, the correlation reported by Heliövaara et al 1 between coVee consumption and RA may, in part, be due to the association between stress and RA.
Knock-in of Mutant K-<i>ras</i> in Nontumorigenic Human Epithelial Cells as a New Model for Studying K-<i>ras</i>–Mediated Transformation
Authors: Hiroyuki Konishi, Bedri Karakas, Abde M. Abukhdeir, Josh Lauring, John P. Gustin, Joseph P. Garay, Yuko Konishi, Eike Gallmeier, Kurtis E. Bachman, Ben Ho Park
Journal: Cancer Research (2007)

Abstract The oncogenic function of mutant ras in mammalian cells has been extensively investigated using multiple human and animal models. These systems include overexpression of exogenous mutant ras transgenes, conditionally expressed knock-in mouse models, and somatic cell knockout of mutant and wild-type ras genes in human cancer cell lines. However, phenotypic discrepancies between knock-in mice and transgenic mutant ras overexpression prompted us to evaluate the consequences of targeted knock-in of an oncogenic K-ras mutation in the nontumorigenic human breast epithelial cell line MCF-10A and hTERT-immortalized human mammary epithelial cells. Our results show several significant differences between mutant K-ras knock-in cells versus their transgene counterparts, including limited phosphorylation of the downstream molecules extracellular signal-regulated kinase and AKT, minor proliferative capacity in the absence of an exogenous growth factor, and the inability to form colonies in semisolid medium. Analysis of 16 cancer cell lines carrying mutant K-ras genes indicated that 50% of cancer cells harbor nonoverexpressed heterozygous K-ras mutations similar to the expression seen in our knock-in cell lines. Thus, this system serves as a new model for elucidating the oncogenic contribution of mutant K-ras as expressed in a large fraction of human cancer cells. [Cancer Res 2007;67(18):8460–7]
Thomas Millar Pollock
Authors: S. Pollock
Journal: BMJ (2004)

Former director epidemiological research laboratory, Central Public Health Laboratory Service, Colindale (b China 1918; q Glasgow 1942; FFCM, FRCP), died from vascular dementia on 12 August 2003.​2003.




Figure 1




Tom Pollock worked for three years as the tuberculosis registrar at the Hounslow chest clinic before joining the scientific staff of the tuberculosis research unit of the Medical Research Council. Following the successful launch of the BCG vaccine Tom moved to the Wellcome Foundation, where he worked for four years on the development of passive vaccination against hepatitis A. In 1964 he joined the Central Public Health Laboratory Service in Colindale as director of the epidemiological research laboratory. After his retirement in 1983, his work on disorders attributed to vaccination became a key plank in the defence of the whooping cough vaccine. Predeceased by his wife, Molly, he leaves two children and four grandchildren.
THE OCCURRENCE OF A POSITIVE INTRACUTANEOUS REACTION IN MENINGOCOCCUS CARRIERS
Authors: FREDERICK P. GAY
Journal: JAMA (1918)

valescence.This fact is further emphasized in the two-stage series, when a preparation of several hun¬ dred days is given to patients who are the poorest of surgical risks, and leads to a convalescence much shorter, than the average.In the two-stage series no attempt was made to chart the incidence of infection, because much of the patients' preoperative time was spent at their homes, where accurate observation was, of course, impossible.CONCLUSIONS 1. Immunity to pyelonephritis by means of mixed colon bacillus vaccine cannot be produced.2. The administration of mixed colon vaccine does not markedly reduce the incidence of genito-urinary infection, if it affects it at all.3. Preoperative attacks of pyelonephritis are the natural means of producing an immunity to renal infection, and their occurrence makes operative risks .less.4. The length of convalescence is usually in inverse proportion to the length of preoperative treatment.
PACAP type I receptor activation regulates ECL cells and gastric acid secretion
Authors: Ningxin Zeng, Christoph Athmann, Tao Kang, Rong-Ming Lyu, John H. Walsh, Gordon V. Ohning, George Sachs, Joseph R. Pisegna
Journal: Journal of Clinical Investigation (1999)

Pituitary adenylate cyclase activating polypeptide (PACAP) is present in gastric nerves, and PACAP receptors (PAC1) are found on gastric enterochromaffin-like (ECL) cells. Expression of PAC1 splice variants in purified ECL cells was determined by RT-PCR. PACAP effects on ECL cells were analyzed by video imaging of [Ca(2+)](i) and histamine release; its effects on gastric glands were examined by confocal microscopy of [Ca(2+)](i) in ECL and parietal cells. PACAP action on D cells was measured by [Ca(2+)](i) and radioimmunoassay. PACAP effects on acid secretion were determined in fistula rats with or without neutralizing anti-somatostatin antibodies. All splice variants of PAC1 were found, but vasoactive intestinal polypeptide (VIP) receptor (VPAC) products were absent. PACAP-27 and -38 dose-dependently raise [Ca(2+)](i) in ECL cells, and stimulated histamine release. VIP had a much lower affinity, which demonstrates the presence of PAC1 but not VPAC. PACAP elevated [Ca(2+)](i) in ECL and parietal cells of superfused gastric glands, but only the parietal cell signal was inhibited by ranitidine, showing the absence of PAC1 on parietal cells, and demonstrating functional coupling between the cell types. PACAP and VIP stimulated calcium signaling and somatostatin release from D cells with almost equal efficacy. Acid secretion was stimulated after intravenous injection of PACAP into rats treated with somatostatin antibody. PACAP is a candidate as a mediator of neural regulation of acid secretion.
Reproductive assistance in HIV serodiscordant couples
Authors: V. Savasi, L. Mandia, A. Laoreti, I. Cetin
Journal: Human Reproduction Update (2012)

BACKGROUNDThree quarters of individuals infected with human immunodeficiency virus (HIV) are in their reproductive years and may consider pregnancy planning. Techniques have been developed which can minimize the risk of HIV transmission in these couples, and the current literature on this topic is reviewed here.
Gonadotropin-Regulated Lymphangiogenesis in Ovarian Cancer Is Mediated by LEDGF-Induced Expression of VEGF-C
Authors: Stav Sapoznik, Batya Cohen, Yael Tzuman, Gila Meir, Shifra Ben-Dor, Alon Harmelin, Michal Neeman
Journal: Cancer Research (2009)

Abstract The risk and severity of ovarian carcinoma, the leading cause of gynecologic malignancy death, are significantly elevated in postmenopausal women. Ovarian failure at menopause, associated with a reduction in estrogen secretion, results in an increase of the gonadotropic luteinizing hormone (LH) and follicle-stimulating hormone (FSH), suggesting a role for these hormones in facilitating the progression of ovarian carcinoma. The current study examined the influence of hormonal stimulation on lymphangiogenesis in ovarian cancer cells. In vitro stimulation of ES2 ovarian carcinoma cells with LH and FSH induced expression of vascular endothelial growth factor (VEGF)-C. In vivo, ovariectomy of mice resulted in activation of the VEGF-C promoter in ovarian carcinoma xenografts, increased VEGF-C mRNA level, and enhanced tumor lymphangiogenesis and angiogenesis. Seeking the molecular mechanism, we examined the role of lens epithelium-derived growth factor (LEDGF/p75) and the possible contribution of its putative target, a conserved stress-response element identified in silico in the VEGF-C promoter. Using chromatin immunoprecipitation, we showed that LEDGF/p75 indeed binds the VEGF-C promoter, and binding is augmented by FSH. A corresponding hormonally regulated increase in the LEDGF/p75 mRNA and protein levels was observed. Suppression of LEDGF/p75 expression using small interfering RNA, suppression of LH and FSH production using the gonadotropin-releasing hormone antagonist cetrorelix, or mutation of the conserved stress-response element suppressed the hormonally induced expression of VEGF-C. Overall, our data suggest a possible role for elevated gonadotropins in augmenting ovarian tumor lymphangiogenesis in postmenopausal women. [Cancer Res 2009;69(24):9306–14]
PERSISTENT ELEVATED LEVELS OF MRP 8/14 AND CARDIOVALCULAR EVENTS AFTER DES IMPLANTATION IN PATIENTS WITH STABLE ANGINA PECTORIS
Authors: Kazuki Mizutani, Takahiko Naruko, Kei Yunoki, Ryushi Komatsu, Kazuo Haze, Akira Itoh, Kenichi Sugioka, Satoko Wada, Yoko Iwasa, Mayumi Inaba, Minoru Yoshiyama, Makiko Ueda
Journal: Journal of the American College of Cardiology (2012)
Further Clinical Experience with Insulin (Pancreatic Extracts) in the Treatment of Diabetes Mellitus
Authors: F. G. Banting, W. R. Campbell, A. A. Fletcher
Journal: BMJ (1923)

Gall Stones and Cholecystitis.-History of colio or jaundice in a small proportion of cases.High incidence in women.Pregnancy and typhoid predisposing and fatness and increasing weight common.Vomiting, nausea, flatulence, distension.Epigastric pain, right subcostal pain, scapular, interscapular,.or shoulder pain.Tendency to diarrhoea or diarrhoea sensations.Shiveriness or slight pyrexia in attacks.Aggravation by exertion, jolting and menstrual periods.Right subcostal tenderness and catch in breath on deep palpation.Referred tenderness over dorsal spines and eleventh right rib behind.Guarding of right upper rectus aind impaired entry at right base in attacks with infected gall blad'er.X rays seldom helpful.Hyperchlorhydria and achylia both more common than in normal subjects.Chronic Appendicular Dyspepsia.-Toofreely diagnosed.History of pcssible acute attacks.Epigastric pain without such definite food relationship as In ulcer, but sometimes closely simulating ulcer.Pain in epigastrium on pressure over appendix.Tender- ness over appendix shadow when visualized with x rays.Positive inflation test.High curves and achylia both more frequent than In normal series.Post-Gastro-enterostomy Dyspepsia.-Thismay be the result of gastric discomforts associated with an inefficient or too efficient stoma and consequently wibb feelings of fullness or empty feelings.It may be due to persistence or recurrence of the original ulcer or to the development of a jejunal ulcer, in which case the maxi- mum tenderness may be found over the stoma, is usually to the left of the mid-line, and commonly at a lower point than obtains in astric ulcer.In jejunal ulcer there is commonly a persistent bigE acidity.Fractional test meal shows bile in all specimens after most gastro-enterostomies, but with an unsatisfactory loop bile may be absent in many specimens.Another type of postgastro-enterostomy dyspepsia is due to too rapid filling of the small Dowel.The symptoms are usually discomforts around the umbilicus and below the area of gastric sensibility.Group 0.Symptoms usually vague.Discomfort rather than pain.Full- ness and feelings of weight in epigastrium.Flatulence.Aggra- vation by prominent causal factors and relief by healthier life, holidays, etc.In fatigue dyspepsias loss of appetite common.Physical examination may show too fat or thin a subject, but local examination negative.Group D.History or family history of tuberculosis, or debility In some cases.Poor appetite, especially in morning, with active disease.In latent disease fullness and discomfort, often aggravated by food, and tending to be worse at the end of the day.A tendency to * A general statement of the physiological and therapeutic effects of insulin, by
Massively representational minds are not always driven by goals, conscious or otherwise
Authors: Bryce Huebner, Robert D. Rupert
Journal: Behavioral and Brain Sciences (2014)

Abstract The language of conscious and unconscious goals is rooted in a folk-taxonomy that is likely to inhibit progress in cognitive science. Severing the commitment to this taxonomy would allow Huang &amp; Bargh (H&amp;B) to consider a wider variety of representational forms with motivational force and to entertain the intriguing possibility that variations in the number of active-but-redundant representations account for variance in social behavior.
A Bulletin Board Service for Residents
Authors: Joseph Kaplan, Julio P. Ruiz
Journal: Annals of Internal Medicine (1990)

Letters and Corrections15 January 1990A Bulletin Board Service for ResidentsJoseph Kaplan, MD, Julio P. Ruiz, MDJoseph Kaplan, MDSearch for more papers by this author, Julio P. Ruiz, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-112-2-151_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:The chief medical residents at Franklin Square Hospital Center have been operating a computer bulletin board (BBS) since March 1989. A recent research grant has permitted us to expand the scope of our BBS through the use of an "800" toll-free number. As a resident-run, resident-oriented computer bulletin board, we believe it to be the first in the nation and as such is an important communication device. The BBS was designated to acquaint residents with procedures used in remote computer operation, provide an open national forum for residents to discuss concerns of importance to medical training, exchange... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Joseph Kaplan, MD; Julio P. Ruiz, MD PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byValue of Pharmacy-Related Bulletin Board Services as a Drug Information Resource 15 January 1990Volume 112, Issue 2Page: 151-151KeywordsComputersResearch grants ePublished: 1 December 2008 Issue Published: 15 January 1990 PDF downloadLoading ...
The Platform Trial
Authors: Scott M. Berry, Jason T. Connor, Roger J. Lewis
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Polymorphisms in<i>MIR27A</i>Associated with Early-Onset Toxicity in Fluoropyrimidine-Based Chemotherapy
Authors: Ursula Amstutz, Steven M. Offer, Johanna Sistonen, Markus Joerger, Robert B. Diasio, Carlo R. Largiadèr
Journal: Clinical Cancer Research (2015)

Abstract Purpose: The microRNA miR-27a was recently shown to directly regulate dihydropyrimidine dehydrogenase (DPD), the key enzyme in fluoropyrimidine catabolism. A common polymorphism (rs895819A&amp;gt;G) in the miR-27a genomic region (MIR27A) was associated with reduced DPD activity in healthy volunteers, but the clinical relevance of this effect is still unknown. Here, we assessed the association of MIR27A germline variants with early-onset fluoropyrimidine toxicity. Experimental Design: MIR27A was sequenced in 514 patients with cancer receiving fluoropyrimidine-based chemotherapy. Associations of MIR27A polymorphisms with early-onset (cycles 1–2) fluoropyrimidine toxicity were assessed in the context of known risk variants in the DPD gene (DPYD) and additional covariates associated with toxicity. Results: The association of rs895819A&amp;gt;G with early-onset fluoropyrimidine toxicity was strongly dependent on DPYD risk variant carrier status (Pinteraction = 0.0025). In patients carrying DPYD risk variants, rs895819G was associated with a strongly increased toxicity risk [OR, 7.6; 95% confidence interval (CI), 1.7–34.7; P = 0.0085]. Overall, 71% (12/17) of patients who carried both rs895819G and a DPYD risk variant experienced severe toxicity. In patients without DPYD risk variants, rs895819G was associated with a modest decrease in toxicity risk (OR, 0.62; 95% CI, 0.43–0.9; P = 0.012). Conclusions: These results indicate that miR-27a and rs895819A&amp;gt;G may be clinically relevant for further toxicity risk stratification in carriers of DPYD risk variants. Our data suggest that direct suppression of DPD by miR-27a is primarily relevant in the context of fluoropyrimidine toxicity in patients with reduced DPD activity. However, miR-27a regulation of additional targets may outweigh its effect on DPD in patients without DPYD risk variants. Clin Cancer Res; 21(9); 2038–44. ©2015 AACR.
Umbilical Vein Cannulation in Portal-System Disease
Authors: Ronald A. Malt, Robert J. Corry, Federico Chávez-Peón
Journal: New England Journal of Medicine (1968)

AFTER birth the umbilical vein collapses and thickens, but by purposeful dilatation of its lumen in adult life it can usually be made to regain its connection with the left branch of the portal vein and to accept a large-bore cannula. In fact, over 75 per cent of umbilical veins can be catheterized for use in the study, diagnosis and treatment of diseases of the portal circulation.1 2 3 4 5 Major difficulties are encountered chiefly in cirrhotic patients with severe nodular distortion of the liver or with massive ascites.EmbryologyDuring the fifth and sixth weeks of pregnancy the pattern of liver vasculature . . .