tbuckley/cabot-search huggingface dataset:
Primary Chemotherapy To Avoid Mastectomy in Tumors With Diameters of Three Centimeters or More
Authors: G. Bonadonna, U. Veronesi, C. Brambilla, L. Ferrari, A. Luini, M. Greco, C. Bartoli, G. C. d. Yoldi, R. Zucali, F. Rilke, S. Andreola, R. Silvestrini, G. D. Fronzo, P. Valagussa
Journal: JNCI Journal of the National Cancer Institute (1990)

Journal Article Primary Chemotherapy To Avoid Mastectomy in Tumors With Diameters of Three Centimeters or More Get access Gianni Bonadonna, Gianni Bonadonna * * Correspondence to: Gianni Bonadonna, M.D., Division of Medical Oncology, Istituto Nazionale Tumori, Via Venezian 1, Milan 20133, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar Umberto Veronesi, Umberto Veronesi Search for other works by this author on: Oxford Academic PubMed Google Scholar Cristina Brambilla, Cristina Brambilla Search for other works by this author on: Oxford Academic PubMed Google Scholar Laura Ferrari, Laura Ferrari Search for other works by this author on: Oxford Academic PubMed Google Scholar Alberto Luini, Alberto Luini Search for other works by this author on: Oxford Academic PubMed Google Scholar Marco Greco, Marco Greco Search for other works by this author on: Oxford Academic PubMed Google Scholar Cesare Bartoli, Cesare Bartoli Search for other works by this author on: Oxford Academic PubMed Google Scholar Gianfranco Coopmans de Yoldi, Gianfranco Coopmans de Yoldi Search for other works by this author on: Oxford Academic PubMed Google Scholar Roberto Zucali, Roberto Zucali Search for other works by this author on: Oxford Academic PubMed Google Scholar Franco Rilke, Franco Rilke Search for other works by this author on: Oxford Academic PubMed Google Scholar ... Show more Salvatore Andreola, Salvatore Andreola Search for other works by this author on: Oxford Academic PubMed Google Scholar Rosella Silvestrini, Rosella Silvestrini Search for other works by this author on: Oxford Academic PubMed Google Scholar Giovanni Di Fronzo, Giovanni Di Fronzo Search for other works by this author on: Oxford Academic PubMed Google Scholar Pinuccia Valagussa Pinuccia Valagussa Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 82, Issue 19, 3 October 1990, Pages 1539–1545, https://doi.org/10.1093/jnci/82.19.1539 Published: 03 October 1990 Article history Received: 21 May 1990 Revision received: 11 July 1990 Accepted: 13 July 1990 Published: 03 October 1990
THE SPECIFIC NATURE OF OPSONINS.
Authors: JOSEPH McFARLAND
Journal: JAMA (1907)

In the course of certain experiments it became important for us to inform ourselves as accurately as possible as to the absolute or relative specificity of opsonins, the close resemblance in nature between opsonins, precipitins, agglutinins, etc., preparing us for the statement that they are specific. This is not, however, as yet entirely proved. Wright and Douglas and Bullock<sup>1</sup>seem satisfied about it, and Bullock made experiments as follows: Serum was digested with staphylococci at 37° C. (98.6° F.) and then freed of the organisms by centrifugalization, after which it was found to have lost all opsonic power for staphylococci, though it largely retained that for tubercle bacilli. Conversely, when digested at 37° C. (98.6° F.) with tubercle bacilli and then centrifugalized, it had lost the opsonin for the tubercle bacillus, though it retained it for the staphylococcus. Potter, Ditman and Bradley,<sup>2</sup>however, came to different experimental results
High titers of IgE antibody to dust mite allergen and risk for wheezing among asthmatic children infected with rhinovirus
Authors: Manuel Soto-Quiros, Lydiana Avila, Thomas A.E. Platts-Mills, John F. Hunt, Dean D. Erdman, Holliday Carper, Deborah D. Murphy, Silvia Odio, Hayley R. James, James T. Patrie, William Hunt, Ashli K. O'Rourke, Michael D. Davis, John W. Steinke, Xiaoyan Lu, Joshua Kennedy, Peter W. Heymann
Journal: Journal of Allergy and Clinical Immunology (2012)

The relevance of allergic sensitization, as judged by titers of serum IgE antibodies, to the risk of an asthma exacerbation caused by rhinovirus is unclear.We sought to examine the prevalence of rhinovirus infections in relation to the atopic status of children treated for wheezing in Costa Rica, a country with an increased asthma burden.The children enrolled (n= 287) were 7 through 12 years old. They included 96 with acute wheezing, 65 with stable asthma, and 126 nonasthmatic control subjects. PCR methods, including gene sequencing to identify rhinovirus strains, were used to identify viral pathogens in nasal washes. Results were examined in relation to wheezing, IgE, allergen-specific IgE antibody, and fraction of exhaled nitric oxide levels.Sixty-four percent of wheezing children compared with 13% of children with stable asthma and 13% of nonasthmatic control subjects had positive test results for rhinovirus (P< .001 for both comparisons). Among wheezing subjects, 75% of the rhinoviruses detected were group C strains. High titers of IgE antibodies to dust mite allergen (especially Dermatophagoides species) were common and correlated significantly with total IgE and fraction of exhaled nitric oxide levels. The greatest risk for wheezing was observed among children with titers of IgE antibodies to dust mite of 17.5 IU/mL or greater who tested positive for rhinovirus (odds ratio for wheezing, 31.5; 95% CI, 8.3-108; P< .001).High titers of IgE antibody to dust mite allergen were common and significantly increased the risk for acute wheezing provoked by rhinovirus among asthmatic children.
Iran plans to ban vasectomies and female sterilisation to boost population
Authors: I. Torjesen
Journal: BMJ (2014)

Vasectomies and female sterilisation are to be banned in Iran after the country’s parliament passed a bill this week aimed at boosting the country’s birth rate, the Islamic Republic News Agency has reported.1 The bill will also ban the advertising of birth control.

Under the bill, which was passed by 143 of 231 members present,2 doctors who perform permanent birth control surgeries, such as vasectomies or tubal ligation, could face fines and prison sentences. Members of the media will also be liable for prosecution if they publicise birth control or other family planning measures.

The rate of contraceptive surgeries in Iran is around four times the global average, said the Iran Daily , an English language newspaper based in Tehran. Around 100 000 Iranian men had vasectomies and …
Is tau a preload-independent measure of isovolumetric relaxation?
Authors: S K Varma, R M Owen, M L Smucker, M D Feldman
Journal: Circulation (1989)

Several studies have been performed in patients with a variety of myocardial diseases that have identified a prolongation of tau. However, it is not clear whether prolongation of tau represents abnormal myocardial physiology or the effect of excessive load associated with a particular disease process. Accordingly, we evaluate the effect on tau of an isolated decrease in preload induced by inferior vena cava occlusion before the appearance of reflex changes in six patients designated as normal by catheterization criteria. A computer-based digitization routine identified cardiac contractions in all patients early after inferior vena cava occlusion where left ventricular end-diastolic pressure decreased (18.3 +/- 6.3 to 9.3 +/- 5.8, p less than 0.05) while left ventricular systolic pressure (113.3 +/- 13.8 to 111.8 +/- 14.0, p = NS) and heart rate (66.0 +/- 10.0 to 65.9 +/- 10.3, p = NS) did not change. After this alteration in preload, no change in tau from baseline, as calculated by the logarithmic (TL), derivative (TD), or method of Mirsky (T1/2), was noted: TL, 47.4 +/- 6.5 to 44.6 +/- 7.6; TD, 39.3 +/- 8.1 to 39.8 +/- 8.4; T1/2, 33.0 +/- 4.0 to 31.8 +/- 4.6; all p = NS. The baseline pressure extrapolated from isovolumetric relaxation did not change in these preload beats compared with baseline (+4.26 +/- 6.20 to -0.80 +/- 4.87, p = NS). Subsequent beats were identified where left ventricular systolic pressure showed a numeric decrease compared with baseline (113.3 +/- 13.8 to 100.8 +/- 14.3, p = NS) despite no change in heart rate (66.0 +/- 10.0 to 66.8 +/- 10.5, p = NS).(ABSTRACT TRUNCATED AT 250 WORDS)
Use of the Asthma Control Questionnaire to predict future risk of asthma exacerbation
Authors: Eli O. Meltzer, William W. Busse, Sally E. Wenzel, Vasily Belozeroff, Haoling H. Weng, JingYuan Feng, Yun Chon, Chiun-Fang Chiou, Denise Globe, Shao-Lee Lin
Journal: Journal of Allergy and Clinical Immunology (2010)
Localization of T25 glycoprotein in wild-type and Thy 1- mutant cells by immunofluorescence and immunoelectron microscopy.
Authors: L Y Bourguignon, R Hyman, I Trowbridge, S J Singer
Journal: The Journal of Experimental Medicine (1978)

The wild-type BW5147 (Thy 1+) cell line and its Thy 1- mutant derivative BW5147 (Thy 1-a) were examined by immunofluorescence and immunoelectron microscopy for the presence of T25, the glycoprotein which bears the Thy 1 alloantigen. The wild-type cell had T25 predominantly localized on the cell surface. In the mutant cell line, T25 accumulated intracellularly and was present in a clustered distribution throughout the cytoplasm. T25 was not present on the surface of the mutant cell line in significant amount.
National Institute of Mental Health Clinical Trials
Authors: Thomas R. Insel, Nitin Gogtay
Journal: JAMA Psychiatry (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
Total Correction of Tetralogy of Fallot
Authors: MURIEL D. WOLF, BERNARD LANDTMAN, CATHERINE A. NEILL, HELEN B. TAUSSIG
Journal: Circulation (1965)

DURING the past two decades great strides have been made in the surgical treatment of tetralogy of Fallot.Prior to 1944, only conservative medical treatment could be offered to these patients.Since the development of the systemic-pulmonary artery shunt operation that year,1 this procedure has been extensively employed all over the world.The symptomatic relief offered by this operation is well known.This operation and its mod- ifications, later supplemented by pulmonary infundibulectomy or valvulotomy (Brock pro- cedure), were for 10 years the only operative procedures available.In 1955 the first patient with tetralogy of Fallot had the defect corrected by open intracardiac surgery.2Since then rapid progress has been made in operative technics and in the methods of extracorporeal perfusion.A sufficiently large number of patients with a tetralogy of Fallot have now undergone open- heart surgery to permit a preliminary evaluation of the results.This paper presents an analysis of the follow-up in the first 146 consecutive pa- tients with tetralogy of Fallot who under- went open-heart surgery at the Johns Hop- kins Hospital from September 1956 to January 1962 and who have been followed until May 1962.The surgical and perfusion technics employed in these cases have been described by Bahnson and associates,3 who also dis- cussed many of the factors concerned in the From the Cardiac Clinic, Harriet Lane Service of the Children's Medical and Surgical Center, The Johns
Relationship between bone mineral content, bone mineral density and anaerobic power in professional jumpers
Authors: Mahdi Haydari, Nader Rahnama, Khalil Khayambashi, Mohammad Marandi
Journal: British Journal of Sports Medicine (2010)

The positive effect of physical activity and exercise on bone mass is well documented in several studies comparing with sedentary subjects. Recent studies have reported that cardiovascular fitness and weight-bearing exercise affect bone mass beneficially. Although it is widely accepted that muscle strength is significantly correlated with bone mass, little is known about anaerobic power and its relation to bone mass. Therefore, the purpose of this study was to analyse the relation between bone mass and anaerobic power in professional jumpers. Thirty professional men jumpers (long, high and triple jumping) with no history of bone disease participated in this study (mean±SD, aged 21.27±3.52 years, height 182±6 cm, weight 69.93±6.01 kg). Bone mineral content (BMC) and bone mineral density (BMD) were measured by dual-energy x-ray absorptiometry. Femoral neck and trochanter BMC and BMD for right and left sides and also lumbar spines were assessed. Sargent jump test was performed by athletes and records were converted to anaerobic power using Lewis formulae. Pearson correlation test was used to analyse data. Results of this study showed a positive relationship between femoral neck and trochanter BMC and anaerobic power (r=0.557, p&lt;0.05). Similar result was found for femoral neck and trochanter BMD and anaerobic power (r=0.446, p&lt;0.05). In conclusion, long-term jumping, is associated with markedly increased BMC and BMD at the femoral neck and trochanter and it can be accounted as one of the important environmental factors to determine femoral BMC and BMD in elite jumpers.
Coronary flow velocity reserve does not correlate with TIMI frame count in patients undergoing non-emergency percutaneous coronary intervention
Authors: Sanjay K. Chugh, Jennifer Koppel, Mark Scott, Lana Shewchuk, David Goodhart, Raoul Bonan, Jean-Claude Tardif, Stephen G. Worthley, Carlo DiMario, Michael J. Curtis, Ian T. Meredith, Todd J. Anderson
Journal: Journal of the American College of Cardiology (2004)
Complaints made easy
Authors: C. Douglas
Journal: BMJ (1996)

Any complaints? Oh. All right. Let's get on with them. What is it today? The mince? The medicine? The universe? Here in Auchendreich, as everywhere else in the NHS, we are getting complaints now about all of the above, and pride ourselves on dealing with them promptly and in strict accordance with official guidance.

Each of us must play our part but there is, of course, a system, and at its heart is a former senior nurse, a motherly ombudswoman for all seasons to whom any patient in the Greater Auchendreich Health Board area can turn in their hour of need. “And there are …
ECHINOCOCCUS CYST OF THE PANCREAS
Authors: CHARLES E. PHILLIPS
Journal: JAMA (1913)

REMOVAL AND RECOVERY  I find a twofold reason for reporting this case: first, on account of the great rarity of the condition, and, secondly, on account of the most unusual history and probable mode of infection.  An idea of the incidence of this disease affecting the pancreas may be gained from a brief review of the literature on the subject. Bergmann1dismisses the subject with the statement that echinococcus cysts of the pancreas have been mentioned, but they occur with great rarity. In Keen2is found the following: Hydatid cysts of the pancreas are extremely rare. Masseron was able to collect the records of only five cases. These were first recognized on the post-mortem table. Graham of Sydney writes: 'The hydatid is sometimes found in the pancreas. I have observed it as a cyst about 3 inches in diameter replacing the head of the organ.' Tricomi states, without
Continuous Positive-Pressure Ventilation: Effects on Systemic Oxygen Transport and Tissue Oxygenation
Authors: JOHN S. LUTCH
Journal: Annals of Internal Medicine (1972)

In this study we examined the effects of continuous positive-pressure (CPP) ventilation at 0, 5, and 10 cm H2O end-expiratory pressure on systemic oxygen transport (cardiac index times arterial oxygen content) and peripheral tissue oxygenation. We studied 19 patients, divided into 3 groups, who required mechanically assisted ventilation: 5 had normal lungs; 10 had decreased lung or chest wall compliance, or both; and 4 had chronic obstructive pulmonary disease. The alveolar-arterial oxygen tension difference narrowed, and hence arterial oxygen content tended to improve in most patients as expiratory pressure increased. Systemic oxygen transport fell in all groups, however, owing to a significant reduction in cardiac index. Despite the fall in oxygen transport, no significant changes occurred in oxygen consumption, respiratory quotient, pH, or mixed venous oxygen tension. We concluded that CPP ventilation significantly decreases cardiac output and oxygen delivery but that total body tissue oxygenation was probably not impaired.
Death shall have no dignity
Authors: T. Dalrymple
Journal: BMJ (2009)

The criticism of the inscriptions on tombstones from the literary point of view is a minor branch of literary criticism as a whole, but there is no doubt that the quality of such inscriptions has declined precipitously in this country since about 1990.

Just as nurses were taught to address their patients by their first names, and diminutives of their first names, on the grounds that it was friendly to do so, so, on tombstones, Mother became Mum, or more often the Americanised “Mom,” there were no fathers any more but only Dads, and Nans, Nanas, Granpas, and Grampys began to appear in large numbers.

Diminutives appeared …
Adynamic Ileus Following Induced Hypertension
Authors: Benjamin A. Lampert
Journal: JAMA (1985)

To the Editor.—  Chen et al 1 found that patients undergoing total hip arthroplasty under general anesthesia had a high incidence of adynamic ileus following nitroprusside-induced hypotension. The authors speculate that diminished mesenteric arterial blood flow was the cause of ileus in this group of patients.  While this may be possible, other considerations should be addressed. Intestinal ischemia may have resulted from increased cyanide levels or methemoglobinemia, secondary to nitroprusside infusion. Hypoxemia may have resulted from nitroprusside-induced inhibition of hypoxic pulmonary vasoconstriction. More importantly, Ebert et al 2 recently reported that cortisol and glucose concentrations rise to significantly higher levels in patients undergoing total hip anthroplasty if sodium nitroprusside is used to induce hypotension. This stress response was greater than in patients under similar anesthetic levels without induced hypotension. Since the sympatho-adrenal axis is thought to mediate adynamic ileus, 3 this would be a more likely cause than mesenteric ischemia
Three Cases of Acute Ketotic Diabetes Mellitus with Myocarditis: A Common Viral Origin?
Authors: P. Gibbs
Journal: BMJ (1974)

Focal electrocardiographic abnormalities have been noted in three young adults who developed acute diabetes after an illness bearing the hallmarks of a viral infection. The persistent S-T and T wave changes were inexplicable in terms of acute electrolyte imbalance or ischaemic heart disease and were ascribed to viral myocarditis. The significance of this is discussed.
Adult Pancreatic Cells “Reprogrammed” Into Rarer Insulin-Producing Cells
Authors: Tracy Hampton
Journal: JAMA (2008)

Researchers have reprogrammed adult exocrine cells from the pancreas into the much different and rarer insulin-producing beta cells, a feat that could lead to improvements in diabetes care (Zhou Q et al. Nature. 10.1038/nature07314 [published online ahead of print August 27, 2008]).
Abstract 2237: Analysis of the PI3K/Akt signaling pathway in neuroblastoma shows stage dependent expression of PI3K isoforms
Authors: Susanne M. Fransson, Frida Abel, Helena Eriksson, Per Kogner, Tommy Martinsson, Katarina Ejeskär
Journal: Cancer Research (2012)

Abstract The phosphoinositide-3 kinase (PI3K) pathway plays a critical role in cancer cell growth and survival and has also been implicated in the development of the childhood cancer neuroblastoma. In neuroblastoma high mRNA expression of the PI3K catalytic isoform PIK3CD is associated to favorable disease. Yet, activation of Akt is associated with poor prognosis. Since the contribution of the numerous members of this pathway to neuroblastoma pathogenesis is mainly unknown, genes of the PI3K/Akt pathway were analyzed at mRNA and/or protein level. Out of 88 studied genes, five (PRKCZ, PRKCB1, EIF4EBP1, PIK3RI and PIK3CD) showed lower mRNA expression and one (PDGFRA) showed higher expression in aggressive compared to favorable tumors. PIK3R1 encodes p85α, the regulatory subunit of the Type IA PI3K and is suggested to have tumor suppressing functions and in neuroblastoma, high expression of PIK3R1 is strongly correlated to overall patient survival. p110α, encoded by PIK3CD was preferentially expressed in favorable neuroblastomas while p110α (encoded by PIK3CA) was mainly found in patients with advanced disease which also showed higher levels of both p-Akt T308 and p-Akt S473. Further more, levels of p-Akt T308 showed inverse correlation to Pten levels although no significant difference in protein levels of Pten could be detected comparing aggressive and favorable neuroblastoma tumors. The pattern of p110alpha and p110delta indicates complementary functions in Akt activation depending on neuroblastoma stage and evaluation of the expression of the different PI3K isoforms in each neuroblastoma patient could be crucial for the success of treatment with PI3K isoform specific inhibitors. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2237. doi:1538-7445.AM2012-2237
GPs must fight against health inequities, conference hears
Authors: A. Moscrop
Journal: BMJ (2009)

Tackling health inequalities means lobbying for political change, GPs were told at a conference in London this week. GPs were urged to become more vocal in demanding positive change to the social determinants of poor health and health inequities, such as housing, education, employment, and taxation.

More than 50 GPs attended the conference, which was hosted by the Royal College …
224. Pyruvate Dehydrogenase Complex Deficiency Caused by the Ubiquitin-Proteasome System-Mediated Degradation in E1β Subunit
Authors: Zongchao Han, Arun Srivastava, Peter Stacpoole
Journal: Molecular Therapy (2006)

We describe a new case of pyruvate dehydrogenase (PDH) complex deficiency associated with the PDH E1|[beta]| subunit (PDHB) gene. The patient was a 5 year old girl with severe developmental delay, microcephaly and agenesis of the corpus callosum. She had mild hyperlactatemia and moderately elevated lactate levels in her cerebrospinal fluid. Her cultured skin fibroblasts demonstrated a 55% reduction in PDH activity and markedly decreased immunoreactivity for PDHB protein, compared to the activity, measured in fibroblasts from healthy controls. The sequence of the total cDNA rorresponding to the patient's E1|[alpha]| and PDHB gene revealed no pathological mutation. The relative expression level of PDHB mRNA (determined by quantitative polymerase chain reaction, qPCR) and the rate of transcription and translation of the PDHB gene were normal. In contrast, the rate of degradation of the patient's E1|[beta]| protein was decreased by the proteosome inhibitor MG132. These data indicate that PDH complex deficiency in this patient is due to enhanced ubiquitination of the E1|[beta]| protein, leading to its accelerated destruction.