tbuckley/cabot-search huggingface dataset:
561 BEST MATCHING FOR HCV GENOTYPE 1 LIVER TRANSPLANT RECIPIENTS IS PREDICTED BY HCV1-STAR. A STUDY FROM AISF RECOLT-C DATABASE
Authors: F.R. Ponziani, A. Milani, A. Gasbarrini, R. Viganò, R.M. Iemmolo, M.F. Donato, M. Rendina, P. Toniutto, L. Pasulo, M. Cescon, E. De Martin, L. Miglioresi, V. Giannelli, D. Di Paolo, S. Fagiuoli, M. Pompili
Journal: Journal of Hepatology (2011)
Deaths from Anaesthetics, 1882
Authors: E. H. Jacob
Journal: BMJ (1883)

mencement of the ninth month, for a week before she was seen by A.n dical.man, had suffered from fever which turned out to be r aittent.On each of the evenings of October 26th and 27tb, 1880, she took fifteen grains of quinine by prescription.I saw her, for the first time, on the 28th, when the first stage of labour was going on, she having spent an uneasy night, and the membranes having ruptured between five and six A.m.The labour finished in the even- ing.Here the temperature had been raised for a week without ex- citing pains, which, however, followed the administration of quinine.In this case there was no history of chronic ailment or miscarriage.Before detailing the next case I may state that, up to this point, I agree with Schrdder in his view that quinine was but a " problem- atic " oxytocic.CASE II is of a much more interesting character; a pluripara, aged 29, having never miscarried, very thin, with a history of old
AB0751 Successfull maintenance treatment of granulomatous polyangiitis (wegener) with rituximab - a case series
Authors: A. Knight, H. Hallenberg, E. Baecklund
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Granulomatous polyangiitis (GPA) is a chronic relapsing systemic vasculitis and repeated remission treatment with cyclophosphamide poses long term safety risks. Studies of rituximab (RTX) have reported successful remission in patients with severe and relapsing GPA, however relapses continue to occur in more than half the patients (1,2). Information about repeated RTX therapy in GPA is limited. <h3>Objectives</h3> To evaluate the efficacy and tolerance of repeated RTX infusions in patients with relapsing GPA, previously treated with cyclophosphamide and other conventional immunosuppressants. <h3>Methods</h3> A retrospective study of the clinical characteristics, previous treatments, disease activity, relapses and tolerance of RTX in GPA patients who had received RTX as maintenance treatment at our department between 2003 and 2011. Patients had to fulfill ACR and/or CHCC criteria for GPA. Disease activity was measured using BVAS. All patients were followed until Dec 31, 2011. <h3>Results</h3> In total eleven patients with repeated RTX infusions were identified, six men and five women, all PR3 ANCA-positive. The patients had previously received a mean of 5,6 different immunosuppressants, including cyclophosphamide and steroids. The mean cumulative dose of cyclophosphamide before RTX treatment was 50 g (range 11-105) and the median number of relapses were 3 (range 1-8). The patients have received a median of four (range 2 -11) maintenance RTX infusions (1000 mg x 2) every six months, with a median follow-up of 18 months from the first infusion (range 9-96). During follow-up no relapses have occurred and BVAS (median) dropped from 9 (range 15-4) before first infusion to 0 (range 2-0) after last infusion. 7 of 11 patients were in remission on Dec 31 2011, defined as BVAS=0 and prednisolone &lt; =7,5 mg. Three patients have stopped all concomitant immunosuppressant treatment. Seven infusion reactions have been noted (in three patients), all could continue treatment. Infections were the most frequently reported adverse events; the majority being "common colds", but seven infections needed treatment with antibiotics and one case of Pneumocystis jiroveci was recorded. <h3>Conclusions</h3> Rituximab as maintenance treatment in this setting of GPA patients, with a median follow-up time of 18 months and receiving a median of four RTX treatments prevented further relapses, gave a good disease control and enabled reduction of steroids and other immunosuppressants. Rituximab was well tolerated but infections may prove an issue. <h3>References</h3> N Engl J Med 2010;363:221-32 2. AnnRheumDis 2011Oct. e-pub) <h3>Disclosure of Interest</h3> None Declared
WATCHMAN for Stroke Prevention: An Out-of-Date Procedure
Authors: Claudia Stöllberger, Josef Finsterer
Journal: Journal of the American College of Cardiology (2007)

With interest we read the article by Sick et al. ([1][1]) about the WATCHMAN left atrial appendage (LAA) system for stroke prevention in atrial fibrillation (AF). We have concerns about the rationale of this technique and questions about the results, which prompt us to challenge the authors’
Countertransference in Factitious Disorder
Authors: H. Wittenberg
Journal: Psychotherapy and Psychosomatics (1994)

In the treatment of patients with factitious disorder it is important to realize that at various levels of their experience these patients are more intimate with death than with life. This requires a particular awareness of resistance mechanisms to countertransference as well as of the importance of clinical procedures, in particular with regard to superego analysis. A requirement for establishing a psychotherapeutic alliance with patients suffering from factitious disorder is a high degree of 'therapeutic eros', hope and trust in one's own capabilities. The emphasis on a 'biophile attitude' does, however, involve the danger that the destructive potential, fantasies of death or killing, but above all feelings of guilt and shame are euphemistically interpreted and played down. A supportive superego analysis is viewed by the patient as playing down her or his 'terror of conscience' and a sense of being left alone. The therapist can be of greater help to the patient by focusing on his or her need and by escorting him or her. This requires that the therapist accept the feelings of relentlessness and hopelessness experienced by the patients in her- or himself. By relinquishing the denial of death-directed tendencies, the therapist is able to establish normality, reality and structure, and is thus in a position to exert a stabilizing effect, initially on her- or himself, but frequently also on the patient, for whom new horizons open.
1163 COMMON VARIATION OF IL28 AFFECTS INTRAHEPATIC EXPRESSION OF INTERFERON STIMULATED GENES AND CORRELATES WITH EFFECT OF PEG-INTERFERON AND RIBAVIRIN COMBINATION THERAPY
Authors: H. Abe, C.N. Hayes, H. Ochi, T. Maekawa, M. Tsuge, D. Miki, F. Mitsui, N. Hiraga, M. Imamura, S. Takahashi, K. Chayama
Journal: Journal of Hepatology (2010)
Acute Anemia with Factor VIII Therapy
Authors: E. G. King, M. E. Clarke, D. I. Buchanan
Journal: Annals of Internal Medicine (1972)

Letters, Comments, and Corrections1 August 1972Acute Anemia with Factor VIII TherapyE. G. KING, M.D., F.A.C.P., M. E. CLARKE, M.D., D. I. BUCHANAN, M.D.E. G. KING, M.D., F.A.C.P.Search for more papers by this author, M. E. CLARKE, M.D.Search for more papers by this author, D. I. BUCHANAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-77-2-323 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Commercial factor VIII concentrates of pooled plasma origin are being used increasingly in minor and major replacement therapy of hemophilia A bleeding episodes. A case has drawn to our attention that significant isoantibody infusion may occur in replacement and produce acute anemia.Patient D.H., an 18-year-old man with hemophilia A underwent emergency cricothyrotomy and tracheotomy 15 December 1971 for gross respiratory distress from a cough-produced paralaryngeal hematoma. On the day of surgery the patient received 28 units of group-specific cryoprecipitate, and for 10 days thereafter he was maintained on 18 to 30 cryoprecipitate units/day. Antihemophilic globulin concentrate...References1. HATHAWAYMAHASANDANACLARKE WCS: Alteration of platelet function after transfusion in hemophilia (abstract) Blood 38:816, 1971 Google Scholar2. ROSATIBARNESOBERMAN LBH: Hemolytic anemia due to anti-A in concentrated anti-hemophilic factor preparations. Transfusion 10:139-141, 1970 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: E. G. KING, M.D., F.A.C.P.; M. E. CLARKE, M.D.; D. I. BUCHANAN, M.D.Affiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLetter to the EditorBLOOD?ITS DERIVATIVES AND ITS PROBLEMS?FACTOR VIIIProthrombin Complex Concentrates in Acquired HypoprothrombinemiaS. G. SANDLER, M.D., F.A.C.P., C. E. RATH, M.D., F.A.C.P., A. RUDER, M.D. 1 August 1972Volume 77, Issue 2Page: 323-324KeywordsAnemiaAttentionBlood plasmaGlobulinsHemophilia AHemorrhageSurgeryTracheotomy ePublished: 1 December 2008 Issue Published: 1 August 1972 PDF downloadLoading ...
Increased health burden associated with comorbid depression in older diabetic Mexican Americans. Results from the Hispanic Established Population for the Epidemiologic Study of the Elderly survey.
Authors: S A Black
Journal: Diabetes Care (1999)

OBJECTIVE: To examine the health burden associated with concomitant depressive symptoms and diabetes in older Mexican Americans. RESEARCH DESIGN AND METHODS: Data from the Hispanic Established Population for the Epidemiologic Study of the Elderly were used to assess the association between high levels of depressive symptoms, measured with the Center for Epidemiologic Studies of Depression scale, and comorbid chronic health conditions, diabetic complications, functional disability, health service use, and medication use among 636 older diabetic Mexican Americans, in comparison with 2,196 older nondiabetic Mexican Americans. RESULTS: Overall, 31.1% of the older diabetic individuals reported high levels of depressive symptoms. The risks of comorbid myocardial infarction, hypertension, arthritis, and angina were significantly higher in the presence of concomitant depressive symptoms, as were the risks of diabetic complications, functional disability, incontinence, vision impairment, poorer perceived health status, and health service use among both diabetic and nondiabetic individuals. Rates were substantially higher among depressed diabetic individuals, however, in comparison to depressed nondiabetic individuals. Importantly, this increased health burden was evident even when controlling for sociodemographic risk factors, including sex, age, level of education, marital status, immigrant status, and living arrangements. CONCLUSIONS: The presence of concomitant depressive symptoms among older diabetic Mexican Americans is associated with a substantially greater health burden than is seen among diabetic individuals without depression or depressed individuals without diabetes. This association of depression with higher rates of chronic conditions, poorer functioning, and increased health service use is particularly significant in that this study was conducted among community-dwelling adults and was not confounded by the potential association of health care-seeking behavior that might occur in a medically ill sample.
Diagnostic and Therapeutic Fistuloscopy: An Adjuvant Management in Postoperative Fistulas and Abscesses after Upper Gastrointestinal Surgery
Authors: S. K. H. Wong, Y. H. Lam, J. Y. W. Lau, D. W. H. Lee, A. C. W. Chan, S. C. S. Chung
Journal: Endoscopy (2000)

Background and Study Aims: Postoperative fistulas and abscesses pose difficult management problems. We report our experience in the use of fistuloscopy in postoperative fistulas and abscesses after upper gastrointestinal surgery.
In Vivo Microscopic Examination of the Esophagus for the Detection of Cancer Before Liver Transplantation in Patients with Alcoholic Cirrhosis
Authors: J. Dumonceau, E. Giostra, R. Genta, G. Mentha, L. Rubbia-Brandt, A. Hadengue
Journal: Endoscopy (2006)

Esophageal squamous-cell carcinoma is relatively common in alcohol and tobacco abusers, and it can develop rapidly after liver transplantation. We report the early detection of an esophageal squamous-cell carcinoma in a patient with alcoholic cirrhosis, diagnosed during the pre-enlistment work-up that he was undergoing before liver transplantation. This lesion had not been detected at standard endoscopy, but was well characterized using in vivo staining and microscopic examination with an “endocytoscopy” system.
Natural orifice transluminal endoscopic surgery
Authors: L. Swanström
Journal: Endoscopy (2009)

Natural orifice transluminal endoscopic surgery (NOTES) is a recent concept, originating as an extension of interventional endoscopy, but more recently being adopted by laparoscopic surgeons and surgical endoscopists as a less-invasive form of laparoscopy. The first published accounts of what would come to be known as “NOTES” (a term coined by the 2005 joint committee of the American Society of Gastrointestinal Endoscopy [ASGE] and the Society of American Gastrointestinal and Endoscopic Surgeons [SAGES] [1]) appeared in 2004. In 2005 and 2006 there were only a handful of papers published on the subject but activity in the form of meeting abstracts and presentations was notable. Starting in 2007 there has been a deluge of papers published on NOTES – 114 in the past 20 months alone ([Fig. 1]).
Researchers Link Early Hair Loss and Prostate Cancer
Authors: M. Fillon
Journal: JNCI Journal of the National Cancer Institute (2013)

Berry believes that virtually all changes in incidence rates of breast cancer are associated with screening, measurement, or use of hormones. If ER-positive disease is going up and ER-negative disease is going down, Berry said, “the easiest answer is that pathologists have changed something [in how they measure hormone receptors], or mammography is changing the detection of the two types of breast cancer. Maybe digital mammography has
From neural constructivism to children's cognitive development: Bridging the gap
Authors: Denis Mareschal, Thomas R. Shultz
Journal: Behavioral and Brain Sciences (1997)

Missing from Quartz &amp; Sejnowski's (Q&amp;S's) unique and valuable effort to relate cognitive development to neural constructivism is an examination of the global emergent properties of adding new neural circuits. Such emergent properties can be studied with computational models. Modeling with generative connectionist networks shows that synaptogenic mechanisms can account for progressive increases in children's representational power.
Abstract IA18: Mechanisms of miRNA mediated cellular reprogramming
Authors: Edward Morrisey
Journal: Cancer Research (2012)

Abstract Recent evidence has indicated that miRNAs have the ability to promote dramatic changes in cell fate including pluripotent stem cell reprogramming. Certain miRNA clusters including miR302/367 are highly expressed in embryonic stem cells and when over-expressed can convert fibroblasts to induced pluripotent stem cells. Moreover, recent publications have shown that certain miRNAs can directly convert fibroblasts to neurons indicating that this technique may be widely applicable to other cell lineages. Despite these intriguing results, little is understood about the molecular mechanism underlying miRNA mediated reprogramming. Since miRNAs can target hundreds of mRNAs, identification of specific targets as well as molecular pathways affected will require multiple approaches. Data will be presented on how our lab is using systems biology and genomic approaches to decipher the underlying mechanism of miRNA-mediated cellular reprogramming. Citation Format: Edward Morrisey. Mechanisms of miRNA mediated cellular reprogramming [abstract]. In: Proceedings of the AACR Special Conference on Noncoding RNAs and Cancer; 2012 Jan 8-11; Miami Beach, FL. Philadelphia (PA): AACR; Cancer Res 2012;72(2 Suppl):Abstract nr IA18.
The Gly972→Arg amino acid polymorphism in IRS-1 impairs insulin secretion in pancreatic β cells
Authors: Ottavia Porzio, Massimo Federici, Marta Letizia Hribal, Davide Lauro, Domenico Accili, Renato Lauro, Patrizia Borboni, Giorgio Sesti
Journal: Journal of Clinical Investigation (1999)

Recent studies have identified several polymorphisms in the human insulin receptor substrate-1 (IRS-1) gene. The most prevalent IRS-1 variant, a Gly→Arg change at the codon 972, has been reported to be increased in prevalence among patients with type 2 diabetes. Carriers of the Arg972 substitution are characterized by lower fasting insulin and C-peptide levels compared with non-carriers, suggesting that the Arg972 IRS-1 variant may contribute to impairment of insulin secretion. In this study, we stably overexpressed both wild-type IRS-1 (RIN-WT) and Arg972 IRS-1 variant (RIN-Arg972) in RIN β cells to investigate directly whether the polymorphism in codon 972 of IRS-1 impairs insulin secretion. The Arg972 IRS-1 variant did not affect expression or function of endogenous IRS-2. RIN-WT showed a marked increase in both glucose- and insulin-stimulated tyrosine phosphorylation of IRS-1 compared with control RIN cells. The Arg972 IRS-1 variant did not alter the extent of either glucose- or insulin-stimulated tyrosine phosphorylation of recombinant IRS-1. However, RIN-Arg972 showed a significant decrease in binding of the p85 subunit of phosphatidylinositol-3-kinase (PI 3-kinase) with IRS-1, compared with RIN-WT. Compared with control RIN cells, insulin content was reduced to the same extent in RIN-WT or RIN-Arg972 at both the protein and mRNA levels. Both glucose- and sulfonylurea-induced insulin secretion was increased in RIN-WT compared with control RIN cells. By contrast, RIN cells expressing Arg972 IRS-1 exhibited a marked decrease in both glucose- and sulfonylurea-stimulated insulin secretion compared with RIN-WT. These data suggest that the insulin signaling pathway involving the IRS-1/PI 3-kinase may play an important role in the insulin secretory process in pancreatic β cells. More importantly, the results suggest that the common Arg972 IRS-1 polymorphism may impair glucose-stimulated insulin secretion, thus contributing to the relative insulin deficiency observed in carriers of this variant.
Massive arterial thrombosis and oral contraception.
Authors: S Adam, M Thorogood
Journal: BMJ (1980)

The authors Holt and Hollanders in their case report on "Massive Arterial Thrombosis and Oral Contraception" maintain that arterial thrombosis is less frequently encountered in association with estrogen containing contraceptives than abnormalities of coagulation or venous thromboembolic diseases and that arterial thromboses are relatively rare. Yet, in the report of the Royal College of General Practitioners study there were 10 deaths attributed to arterial thrombosis compared with 1 death attributed to venous thromboembolism in women who had used oral contraception (OC), either currently or in the past. Similarly, of the 9 cardiovascular deaths reported in the Oxford-FPA study, all of which were in women who had used OC at some time, 5 deaths were directly attributable to arterial thrombosis. Although clinicians may still be more aware of the association of OC with deep venous thrombosis and pulmonary embolisms as Drs. Holt and Hollanders suggest, arterial thrombosis accounts for a greater proportion of the increased mortality which may be attributed to OC. Furthermore, although the occurrence of massive arterial thrombosis may be unusual, in a study of all deaths during 1978 in England and Wales in women between 16-44 years of age, 3 women were found to have died of widespread large artery thrombosis without venous involvement. Finally, anecdotal case reports play an important role in suggesting new etiological hypotheses and in directing the attention of future epidemiological research.
Abolition of agency reduces Aboriginal input on health policy
Authors: Bob Burton
Journal: BMJ (2004)

The Australian government has rejected recommendations of a panel reviewing the performance of the main elected body representing Aboriginal people, the Aboriginal and Torres Strait Islander Commission, and instead announced it will abolish the commission, despite its role in influencing national health policy.

The panel's report, which was given to the government in November 2003, noted the important role of a reformed commission in ensuring the input of indigenous communities into health policy.

Last week Prime Minister John Howard announced that the commission would be abolished. “We believe very strongly that the experiment in …
IgG, β<sub>1</sub>C, Fibrinogen Cryoprotein in Acute Glomerulonephritis
Authors: Rawle M. McIntosh, Burton Grossman
Journal: New England Journal of Medicine (1971)

CRYOPROTEINS have been isolated in a variety of immune-complex renal diseases, including glomerulonephritis.1 2 3 Although cryoproteins containing individual or combinations of immunoglobulins have been isolated from serum specimens of patients with acute nephritis, the presence of fibrinogen or fibrinogen products (or both) in the cryoprecipitates has not to our knowledge been detected. In the following case acute glomerulonephritis was associated with IgG, β1C, fibrinogen and cold-insoluble precipitate.Case ReportIn a 13-year-old boy edema and gross hematuria developed 10 days after an upper respiratory infection. Two weeks later he was admitted to La Rabida-University of Chicago Institute, where he . . .
SPINAL ANESTHESIA EXCLUDING THE MOTOR NERVES
Authors: Edward G. Martin
Journal: JAMA (1931)

To the Editor:  —The first spinal anesthetic that I recall at Harper Hospital was in 1903, when the German preparation stovaine was used. There was considerable toxicity reported following the use of this preparation in this country, and spinal anesthesia did not become really popular until the advent of procaine hydrochloride. Since then its popularity has increased until at the present time it is the anesthetic of choice in most of those cases in which general anesthesia was formerly administered. It may be said that there are two schools who enjoy debating respectively the superiority of spinocaine (lighter than the spinal fluid) and plain procaine dissolved in the spinal fluid itself. What speaks most eloquently for spinal anesthesia is to observe the ultraconservative surgeons adopting it as first choice in most of their work.  Following the administration of the average dose of procaine, from 100 to 200 mg., its effectiveness
Difficult Consultations with Adolescents
Authors: Domhnall MacAuley
Journal: BMJ (2004)

Talking to a different generation can be like communicating with aliens. In the eyes of a 15 year old, someone of 20 is ancient, and people in their 30s know nothing about sex, spots, music, or clothes. You cannot dance, you dress like a chump, and you cause embarrassment if you kiss your wife. By 40, forget it. Let's face it, we are what teenagers would call a bunch of nerds.

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Chris Donovan, Heather C Suckling

Radcliffe Medical Press, £21.95, pp 130 ISBN 1 85775 882 X

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Hypertension in general practice
Authors: J Woolich
Journal: BMJ (1984)

sion ?If treated with an up to date drug regimen what success is achieved in blood pressure reduction ?We hope to publish results within the next year, and should the MRC trial show benefits from the treatment of mild to moderate hypertension, we will be able to comment on case finding and general practitioner follow up as a practical alternative to an expensive screening technique.This will have important consequences for general practice, for the National Health Service, and, most im- portantly, for the patient.