Extramedullary Plasmacytoma: A Localized or Systemic Disease?
Authors: F. Javier Laso
Journal: Annals of Internal Medicine (1998)

Letters15 January 1998Extramedullary Plasmacytoma: A Localized or Systemic Disease?F. Javier Laso, MD, PhD, M. Dolores Tabernero, MD, PhD, and M. Carmen Iglesias-Osma, MD, PhDF. Javier Laso, MD, PhDUniversity of Salamanca; 37007 Salamanca, Spain, M. Dolores Tabernero, MD, PhDUniversity of Salamanca; 37007 Salamanca, Spain, and M. Carmen Iglesias-Osma, MD, PhDUniversity of Salamanca; 37007 Salamanca, SpainAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-2-199801150-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Extramedullary plasmacytoma is an uncommon variant of plasma cell dyscrasia that develops outside the bone; most cases (76%) occur in the upper respiratory tract [1]. Lung involvement is rare; only 20 cases have been reported [2]. For the definition of primary extramedullary plasmacytoma, a normal radiographic survey in the absence of bone marrow infiltration is required. The latter criterion has classically been assessed by conventional morphology. Now, however, more sensitive approaches are available for the identification of bone marrow involvement. These studies would help elucidate whether extramedullary plasmacytoma is a localized or an already disseminated disorder.A ...References1. Wiltshaw E. The natural history of extramedullary plasmacytoma and its relation to solitary myeloma of bone and myelomatosis. Medicine (Baltimore). 1976; 55:217-38. Google Scholar2. Joseph G, Pandit M, Korfhage L. Primary pulmonary plasmacytoma. Cancer. 1993; 71:721-4. Google Scholar3. Orfao A, Garcia-Sanz R, Lopez-Berges MC, Vidriales MB, Gonzalez M, Caballero MD, et al. A new method for the analysis of plasma cell DNA content in multiple myeloma samples using a CD38/propidium iodide double staining technique. Cytometry. 1994; 17:332-9. Google Scholar4. Tabernero MD, San Miguel JF, Garcia VL, Garcia-Isidoro M, Wiegant J, Ciudad J, et al. Clinical, biological, and immunophenotypical characteristics of B-cell chronic lymphocytic leukemia with trisomy 12 by fluorescence in situ hybridization. Cytometry. 1995; 22:217-22. Google Scholar5. Tabernero MD, San Miguel JF, Garcia-Sanz R, Najera L, Garcia-Isidoro M, Perez-Simon JA, et al. Incidence of chromosome numerical changes in multiple myeloma: fluroescence in situ hybridization analysis using 15 chromosome-specific probes. Am J Pathol. 1996; 149:153-61. Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Salamanca; 37007 Salamanca, Spain PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByClinical Course of a Patient With Kidney Failure Due to Isolated Bilateral Renal Extramedullary PlasmacytomasExtramedullary Cardiac Multiple Myeloma—A Case Report and Contemporary Review of the LiteratureMultiple myeloma with intracranial extension and bilateral renal infiltration: A case report and review of the literatureRenal plasmacytoma: Report of a rare case and review of the literatureTesticular plasmacytoma: a case report and review of the literatureCT Findings of Perirenal PlasmacytomaPlasmocitoma cutáneo gigante como primera manifestación de mieloma múltiple 15 January 1998Volume 128, Issue 2Page: 156KeywordsAneuploidyBone marrowCellsCytogeneticsDNALungsPlasma cellsSystemic diseasesThoraxTrisomy Issue Published: 15 January 1998 CopyrightCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...