The Diagnosis of Disseminated Histoplasmosis from Marrow Aspiration
Authors: ARTHUR A. COOPERBERG
Journal: Annals of Internal Medicine (1964)

Article1 August 1964The Diagnosis of Disseminated Histoplasmosis from Marrow AspirationARTHUR A. COOPERBERG, M.D., F.A.C.P., JACK SCHWARTZ, M.D.ARTHUR A. COOPERBERG, M.D., F.A.C.P.Search for more papers by this author, JACK SCHWARTZ, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-2-289 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDisseminated histoplasmosis is a systemic fungus disease characterized by weakness, weight loss, fever, hepatosplenomegaly, anemia, and frequently by leukopenia. The diagnosis is based on visualization of the intracellular organisms in biopsy material or on culture of sputum, blood, bone marrow, urine, cerebrospinal fluid, and liver from a biopsy specimen.Although reference is frequently made to bone marrow cultures (1-3), too little attention has been paid to the direct examinations of the marrow smears in the diagnosis of disseminated histoplasmosis. The organisms have indeed been described on occasion in the bone marrow (4-11), but little use appears to have been made...References1. CECILLOEB RLRF: A Textbook of Medicine, W. B. Sounders Company, Philadelphia, 1963, p. 330. Google Scholar2. TYNESCRUTCHERUTZ BSJAJP: Histoplasma meningitis. Ann. Intern. Med. 59: 615, 1963. LinkGoogle Scholar3. RUBINFURCOLOWYATESBRASHER HMLJLCA: The course and prognosis of histoplasmosis. Amer. J. Med. 27: 278, 1959. CrossrefMedlineGoogle Scholar4. PARSONSZARAFONETIS RJCJ: Histoplasmosis in man: report of seven cases and a review of seventy-one cases. Arch. Intern. Med. (Chicago) 75: 1, 1945. CrossrefGoogle Scholar5. MOFFETNAJJARCRAMBLETT HLSHG: Successful therapy of disseminated histoplasmosis through the use of amphotericin B. J. Iowa State Med. Soc. 49: 625, 1959. MedlineGoogle Scholar6. PRATTSCHWARTZEHRLICK PTSOL: Aspiration biopsy of bone marrow as an aid in diagnosis of histoplasmosis: report of a case. Arch. Intern. Med. (Chicago) 85: 893, 1950. CrossrefGoogle Scholar7. ROHNBOND RJWH: The value of the routine bone marrow culture for Histoplasma capsulatum in pediatric hematology. Blood 8: 329, 1953. CrossrefMedlineGoogle Scholar8. PEASE GL: Granulomatous lesions in bone marrow. Blood 11: 720, 1956. CrossrefMedlineGoogle Scholar9. CONANTMARTINSMITHBAKERCALLAWAY NFDSDTRDJL: Manual of Clinical Mycology. W. B. Saunders & Company, Philadelphia, 1946, p. 156. Google Scholar10. CUSTER RP: An Atlas of the Blood and Bone Marrow. W. B. Saunders & Company, Philadelphia, 1949, p. 223. Google Scholar11. MOSSMCQUOWN ESAI: Atlas of Medical Mycology. Williams & Wilkins Co., Baltimore, 1960, p. 195. Google Scholar12. EDITORIAL: Increasing recognition of the severity of certain types of histoplasmosis. JAMA 177: 325, 1961. CrossrefGoogle Scholar13. CRAIGFARBER JMS: Development of disseminated visceral mycosis during therapy for acute leukemia. Amer. J. Path. 29: 601, 1953. Google Scholar14. ZIMMERMAN LE: Fatal fungus infections complicating other diseases. Amer. J. Clin. Path. 25: 46, 1955. CrossrefMedlineGoogle Scholar15. HUTTERCOLLINS RVHS: Occurrence of opportunistic fungous infections in a cancer hospital. Lab. Invest. 11: 1035, 1962. MedlineGoogle Scholar16. GRUHNSANSON JGJ: Mycotic infections in leukemia patients at autopsy. Cancer 16: 61, 1963. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From the Division of Hematology, Department of Medicine, Jewish General Hospital, Montreal, Canada.Requests for reprints should be addressed to A. A. Cooperberg, M.D., Jewish General Hospital, 3755 Cote St. Catherine Road, Montreal, Canada. 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SMITH, M.D., JOHN P. UTZ, M.D., F.A.C.P.HistoplasmosisHistoplasmosisDie HistoplasmoseBronchopulmonary Lavage in Normal Subjects and Patients with Obstructive Lung DiseaseT. N. FINLEY, M.D., E. W. SWENSON, M.D., W. S. CURRAN, M.D., G. L. HUBER, M.D., A. J. LADMAN, PH.D. 1 August 1964Volume 61, Issue 2Page: 289-295KeywordsBiopsyBone marrowHistoplasmosisHospital medicineMetastasisRisk managementSputumSystemic diseasesUrineWeight loss Issue Published: 1 August 1964 PDF downloadLoading ...