tbuckley/cabot-search huggingface dataset:
Coordinated Expression of Stathmin Family Members by Far Upstream Sequence Element-Binding Protein-1 Increases Motility in Non–Small Cell Lung Cancer
Authors: Stephan Singer, Mona Malz, Esther Herpel, Arne Warth, Michaela Bissinger, Martina Keith, Thomas Muley, Michael Meister, Hans Hoffmann, Roland Penzel, Georg Gdynia, Volker Ehemann, Philipp Albert Schnabel, Ruprecht Kuner, Peter Huber, Peter Schirmacher, Kai Breuhahn
Journal: Cancer Research (2009)

Dynamic instability of the microtubule network modulates processes such as cell division and motility, as well as cellular morphology. Overexpression of the microtubule-destabilizing phosphoprotein stathmin is frequent in human malignancies and represents a promising therapeutic target. Although stathmin inhibition gives rise to antineoplastic effects, additional and functionally redundant microtubule-interacting proteins may attenuate the efficiency of this therapeutic approach. We have systematically analyzed the expression and potential protumorigenic effects of stathmin family members in human non-small cell lung cancer (NSCLC). Both stathmin and stathmin-like 3 (SCLIP) were overexpressed in adenocarcinoma as well as squamous cell carcinoma (SCC) tissues and induced tumor cell proliferation, migration, and matrix invasion in respective cell lines. Accordingly, reduced stathmin and SCLIP levels affected cell morphology and were associated with a less malignant phenotype. Combined inhibition of both factors caused additive effects on tumor cell motility, indicating partial functional redundancy. Because stathmin and SCLIP expression significantly correlated in NSCLC tissues, we searched for common upstream regulators and identified the far upstream sequence element-binding protein-1 (FBP-1) as a pivotal inducer of several stathmin family members. Our results indicate that the coordinated overexpression of microtubule-destabilizing factors by FBP-1 is a critical step to facilitate microtubule dynamics and subsequently increases proliferation and motility of tumor cells.
Pure Red Cell Aplasia and Lymphoma
Authors: Harry W. Carloss
Journal: JAMA (1979)

THE ASSOCIATION of pure red cell aplasia (PRCA) with thymoma 1 is well known. The disease also may be associated with a variety of other conditions, including paraproteinemia. 1-4 However, its association with lymphomas occurs infrequently. We have found only one report of PRCA in the course of histiocytic lymphoma. 5   The rarity of this association is intriguing because autoimmunity is now believed to play a part in the pathogenesis of PRCA, and the incidence of autoimmune phenomena in the course of lymphoproliferative disorders has been documented. 6   We describe a case of PRCA that occurred a few months after the diagnosis of poorly differentiated lymphocytic lymphoma.  Report of a Case  A 27-year-old previously healthy woman complained of chest pain and progressive dyspnea. One month before admission she noted bilateral axillary lymphadenopathy, fever, and weight loss. Examination showed splenomegaly, ascites, and right pleural effusion confirmed by roentgenogram. Thoracentesis yielded 950
Cell Surface-Dependent Generation of Angiostatin4.5
Authors: Hao Wang, Ryan Schultz, Jerome Hong, Deborah L. Cundiff, Keyi Jiang, Gerald A. Soff
Journal: Cancer Research (2004)

Abstract Angiostatin4.5 (AS4.5) is a naturally occurring human angiostatin isoform, consisting of plasminogen kringles 1–4 plus 85% of kringle 5 (amino acids Lys78 to Arg529). Prior studies indicate that plasminogen is converted to AS4.5 in a two-step reaction. First, plasminogen is activated to plasmin. Then plasmin undergoes autoproteolysis within the inner loop of kringle 5, which can be induced by a free sulfhydryl donor or an alkaline pH. We now demonstrate that plasminogen can be converted to AS4.5 in a cell membrane-dependent reaction. Actin was shown previously to be a surface receptor for plasmin(ogen). We now show that β-actin is present on the extracellular membranes of cancer cells (PC-3, HT1080, and MDA-MB231), and β-actin can mediate plasmin binding to the cell surface and autoproteolysis to AS4.5. In the presence of β-actin, no small molecule-free sulfhydryl donor is needed for generation of AS4.5. Antibodies to actin reduced membrane-dependent generation of AS4.5 by 70%. In a cell-free system, addition of actin to in vitro-generated plasmin resulted in stoichiometric conversion to AS4.5. Annexin II and α-enolase have been reported to be plasminogen receptors, but we did not demonstrate a role for these proteins in conversion of plasminogen to AS4.5. Our data indicate that membrane-associated β-actin, documented previously as a plasminogen receptor, is a key cell membrane receptor capable of mediating conversion of plasmin to AS4.5. This conversion may serve an important role in regulating tumor angiogenesis, invasion, and metastasis, and surface β-actin may also serve as a prognostic marker to predict tumor behavior.
In situ nucleic acid hybridization of cytokines in primary biliary cirrhosis: Predominance of the Th1 subset
Authors: K Harada, J Van de Water, P S Leung, R L Coppel, A Ansari, Y Nakanuma, M E Gershwin
Journal: Hepatology (1997)

Primary biliary cirrhosis (PBC) is an autoimmune liver disease characterized by destruction of the intrahepatic bile ducts. It is generally believed that cellular immune mechanisms, particularly involving T cells, result in this bile duct damage. The relative strength of Th1 and Th2 responses has recently been proposed to be an important factor in the pathophysiology of various autoimmune diseases. In this study, we have attempted to identify the Th subset balance in PBC, by detection of cytokines specific to the two T-cell subsets, i.e., interferon γ (IFN-γ) for Th1 cells and interleukin-4 (IL-4) for Th2 cells. We analyzed IFN-γ and IL-4 messenger RNA (mRNA) positive cells in liver sections from 18 patients with PBC and 35 disease controls including chronic active hepatitis C, extrahepatic biliary obstruction (EBO), and normal liver, using nonisotopic in situ hybridization and immunohistochemistry. Mononuclear cells expressing IFN-γ and IL-4 mRNA were aggregated in inflamed portal tracts in PBC livers, but were rarely present in extrahepatic biliary obstruction, alcoholic fibrosis, or normal liver sections. The IFN- γ and IL-4 mRNA positive cells in PBC livers were detected in significantly higher numbers than in control livers ( P &lt; .01). Moreover, IFN-γ mRNA expression was more commonly detected than IL-4 expression in PBC livers, and the levels of IFN-γ mRNA expression were highly correlated with the degree of portal inflammatory activity. IFN-γ mRNA-positive cells were detected primarily around damaged bile ducts that were surrounded by lymphoid aggregates. The data indicate that Th1 cells are the more prominent T-cell subset in the lymphoid infiltrates in PBC.
Integrating evolutionary and social science approaches to the family
Authors: Donald Cox
Journal: Behavioral and Brain Sciences (2010)

Abstract Recent work on the evolution of utility has brought the blunt instrument of kin selection closer to the cluttered scalpel kit of social science. The concept of diminishing marginal utility can help streamline the latter. Reconciling ultimate causes with proximate inclinations, however, will be easier for the case of assistance from grandparents than assistance to them.
Ashworth announces its reform plan
Authors: A. Ferriman
Journal: BMJ (1999)

Ashworth Hospital, which was recommended for closure in January in a damning report (23 January, p 211), has produced an action plan to overcome its failings.

The Merseyside hospital, which has a personality dis-order unit that houses some of England and Wales's most disturbed and dangerous patients, will receive £5.7m ($9.1m) …
Cecil-Loeb Textbook of Medicine
Authors: Lester S. King
Journal: JAMA (1967)

When a textbook has reached its 40th birthday and its 12th edition,<sup>1</sup>it becomes exceedingly difficult to review. Many reviews will appear, of course, but for the most part they will comment, say, on the number of pages and "view with alarm" the almost inevitable increases; they will indicate the major changes since the preceding edition, such as the number of new contributors and new articles—information the editors conveniently provide in the preface. The adventuresome reviewer may weigh the book and reveal its avoirdupois, leaf through the references to tell us what proportion bears a recent date, and then make a few comments on those textual areas with which he is best acquainted. But the book has now achieved such a solid position that a methodological and historical critique may be more significant than a conventional review. However, first let me provide the data which the reader naturally expects.
Tissue repair response as a function of dose in thioacetamide hepatotoxicity.
Authors: R S Mangipudy, S Chanda, H M Mehendale
Journal: Environmental Health Perspectives (1995)

The purpose of the present study was to establish a dose-response relationship for thioacetamide (TA), where tissue regeneration as well as liver injury were two simultaneous but opposing responses. Male Sprague-Dawley rats were injected intraperitioneally with a 12-fold dose range of TA, and both liver injury and tissue repair were measured. Liver injury was assessed by serum enzyme elevations. Serum alanine aminotransferase (ALT) elevation did not show any dose response over a 12-fold dose range up to 24 hr. A dramatic ALT elevation was evident after 24 hr and only for the highest dose (600 mg/kg). Tissue regeneration response was measured by 3H-thymidine (3H-T) incorporation into hepatocellular DNA and by proliferating cell nuclear antigen (PCNA) procedure during a time course (6, 12, 24, 36, 48, 72, and 96 hr). Tissue regeneration, as indicated by 3H-T incorporation, peaked at 36 hr after administration of a low dose of TA (50 mg/kg). With increasing doses, a greater but delayed stimulation of cell division was observed until a threshold was reached (300 mg/kg). Above the tissue repair threshold (600 mg/kg), because stimulated tissue repair as revealed by 3H-T incorporation in hepatonuclear DNA was significantly delayed and attenuated, injury assessed by serum enzyme elevations was remarkably accelerated, indicating unrestrained progression of injury leading to animal death. These findings suggest that, in addition to the magnitude of tissue repair response, the time at which this occurs is critical in restraining the progression of injury, thereby determining the ultimate outcome of toxicity.(ABSTRACT TRUNCATED AT 250 WORDS)
A 43-Year-Old Woman With End-Stage Renal Disease, 2 Years 6 Months Later
Authors: Amy N. Ship
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Phase I/II study of vesigenurtacel-l (hs-410) or placebo in combination with Bacillus Calmette-Guérin (BCG) in patients with non-muscle invasive bladder cancer (NMIBC)
Authors: Gary D Steinberg, Neal Shore, Lawrence Karsh, James Bailen, Michael Woods, Mark Schoenberg, Taylor H Schreiber, Melissa Price
Journal: Journal for ImmunoTherapy of Cancer (2014)

Meeting abstracts Vesigenurtacel-L is an allogeneic cell-based therapeutic cancer vaccine that was selected based on its expression of a range of tumor antigens (surviving, LAGE-1, MAGE-A3, MAGE-A11, PRAME and others) that are known to be expressed amongst a high proportion of primary bladder
Further Observations on the Ventricular Echo Phenomenon Elicited in the Human Heart
Authors: REINIER M. SCHUILENBURG, DIRK DURRER
Journal: Circulation (1972)

In order to answer the question whether the atrium is a link in the pathway of ventricular reciprocation or whether the A-V node itself is the reflection point of the echo, a special stimulation program was followed in six patients in whom ventricular echo beats with stable time relations could be elicited by regular pacing of the right ventricle or by the application of appropriately timed right ventricular premature beats during regular pacing of the right ventricle. In these experiments the atrial septum was stimulated earlier than the expected arrival at the atrium of the retrograde impulse in the course of the echo sequence. The influence of stepwise (steps of 5 msec) advancing of this atrial "preexcitation" on the timing of the ventricular echo beat was studied. We found that the atrial septum could be preexcited without interfering with the ventricular echo beat time relations over a time interval less than 5 msec in one patient, less than 10 msec in one, less than 20 msec in two, and less than 30 msec in two cases. When the time interval needed for the stimulated atrial impulse to reach the atrionodal margin is taken into account, it seems likely that the atrium participated in the echo pathway in the four cases with minimal atrial preexcitation intervals of 20 msec or less, and that in the two cases with a minimal atrial preexcitation interval of 30 msec the echo reflection point was localized in the upper part of the A-V node.
TCTAP A-067 The Impact of Angiographic Peri-contrast Staining After Second the Impact of Angiographic Peri-contrast Staining After Second Generation DES Implantationeneration DES Implantation
Authors: Takahiro Tokuda, Toshiya Muramatsu, Reiko Tsukahara, Yoshiaki Ito, Hiroshi Ishimori, Keisuke Hirano, Masatsugu Nakano, Motoharu Araki, Tamon Kato, Norihiro Kobayashi, Yasunari Sakamoto, Hideyuki Takimura, Shinsuke Mori, Hiroya Takafuji, Makino Kenji
Journal: Journal of the American College of Cardiology (2014)
Growth Rate in the Detection and Prognosis of Bronchogenic Carcinoma
Authors: William Weiss
Journal: JAMA (1966)

Volume-doubling time was used as an index of growth rate for 18 solitary nodules due to bronchogenic carcinoma. This series from the Philadelphia Pulmonary Neoplasm Research Project was limited to cases whose tumors could be measured on serial chest x-ray films and in whom death, if it occurred, was attributable to the cancer. The distribution of doubling times suggests that, if lung cancer is to be detected soon after it reaches roentgenographic visibility, the interval between serial films must be less than six months in many cases. Whether such a program would improve the cure rate remains to be determined. Doubling time was plotted against survival measured from the time when the cancer was 1 cm in diameter. The slower the growth rate, the longer was the survival.
A Salty Taste to Autoimmunity
Authors: Jos W.M. van der Meer, Mihai G. Netea
Journal: New England Journal of Medicine (2013)

Type 17 helper (Th17) cells are primary mediators of inflammation. Data from two recent studies suggest that salt enhances the inflammatory responses of Th17 cells in the mouse, as well as the severity of disease in a mouse model of multiple sclerosis.
Blood Products for Spanish Influenza: A Future H5N1 Treatment?
Authors: Susan J. Logtenberg, Henk J. Bilo
Journal: Annals of Internal Medicine (2007)

Letters1 May 2007Blood Products for Spanish Influenza: A Future H5N1 Treatment?Susan J. Logtenberg, MD and Henk J. Bilo, MD, PhDSusan J. Logtenberg, MDFrom Isala Clinics, 8025 AB, Zwolle, the Netherlands.Search for more papers by this author and Henk J. Bilo, MD, PhDFrom Isala Clinics, 8025 AB, Zwolle, the Netherlands.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-146-9-200705010-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR: We would like to add to the discussion in Luke and colleagues' meta-analysis (1) of historic literature about the possible beneficial effect of transfusion on the clinical outcome of patients with Spanish influenza. We suggest that the effect might not be due to the specific neutralizing effects of anti-influenza antibodies in the blood product but rather to the transfusion of whole blood, including immunoglobulins (and thus the provision of plasma oncotic pressure).We recently reported on a previously healthy man with severe shock who required admission to the intensive care unit. His condition was associated with an ...References1. Luke TC, Kilbane EM, Jackson JL, Hoffman SL. Meta-analysis: convalescent blood products for Spanish influenza pneumonia: a future H5N1 treatment? Ann Intern Med. 2006;145:599-609. [PMID: 16940336] LinkGoogle Scholar2. Logtenberg SJ, Pasma FH, Wolfhagen MJ, Dikkeschei LD, Bilo HJ. Disappearance of immunoglobulins in acute phase of influenza A infection. Lancet. 2006;368:1546. [PMID: 17071289] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Isala Clinics, 8025 AB, Zwolle, the Netherlands.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoMeta-Analysis: Convalescent Blood Products for Spanish Influenza Pneumonia: A Future H5N1 Treatment? Thomas C. Luke , Edward M. Kilbane , Jeffrey L. Jackson , and Stephen L. Hoffman Blood Products for Spanish Influenza: A Future H5N1 Treatment? Thomas C. Luke and Stephen L. Hoffman Metrics Cited ByPotential Drugs and Remedies for the Treatment of COVID-19: a Critical ReviewEarly experience with convalescent plasma as immunotherapy for COVID‐19 in China: Knowns and unknownsNew Wisdom to Defy an Old Enemy: Summary from a scientific symposium at the 4th Influenza Vaccines for the World (IVW) 2012 Congress, 11 October, Valencia, Spain 1 May 2007Volume 146, Issue 9Page: 686-687KeywordsBloodBlood plasmaBlood transfusionConflicts of interestForecastingH5N1Influenza A virusIntensive care unitsProteins ePublished: 1 May 2007 Issue Published: 1 May 2007 CopyrightCopyright © 2007 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Spontaneous tetraplegia during weight training
Authors: G Clewer, M Carmont, D Jaffray
Journal: British Journal of Sports Medicine (2006)

A case of tetraplegia due to weight training is presented. Emergency surgery revealed a huge C5/6 disc sequestration trapped within the canal by the posterior longitudinal ligament. The disc was removed and C5–C7 were fused using an iliac crest tricortical graft and stabilised. The patient made a good recovery and returned to sporting activity.
Aging: An Exploration
Authors: T. L. Brink
Journal: JAMA (1984)

Recently I addressed the local Rotary Club about aging. This book has the same easy, upbeat, but no-nonsense tone as did that speech. Barash has a well-deserved reputation as someone who writes well, regardless of the subject (Sociobiology and Behavior, 1977;The Whisperings Within, 1979; andStop Nuclear War, 1982). This is not a tightly reasoned discourse on technical topics such as methodology, epidemiology, diagnosis, or treatment. However, Barash has the ability to comprehend and discuss technical data with the sophistication that one would expect from a professor of psychology and zoology.  The content of this book is as interdisciplinary as it could be, ranging from mythology to literature to a history of rejuvenationism to anthropology to sociology, but the central theme of the book is on medically oriented topics such as the aging mind, body, and sex life.  For patients who respond to bibliotherapy, this would be an
Discordance between Plasma Calcitonin and Tumor-Cell Mass in Medullary Thyroid Carcinoma
Authors: Donald L. Trump, Geoffrey Mendelsohn, Stephen B. Baylin
Journal: New England Journal of Medicine (1979)

MEDULLARY thyroid carcinomas always secrete calcitonin, leading to an increased plasma hormone concentration.1 The plasma calcitonin concentration usually correlates with the clinical extent of disease.2 This article describes a patient with medullary thyroid carcinoma in whom plasma calcitonin did not correlate with estimated tumor burden. Although the tumor had metastasized widely, plasma calcitonin concentration was unexpectedly low. Immunohistochemical analysis of tumor tissue provides an explanation for this observation and illustrates a potentially important feature of human tumor biology.Case ReportA 46-year-old man underwent hemithyroidectomy after the discovery of a thyroid nodule, which proved to be a medullary thyroid carcinoma. . . .
Vitamin A programme in Assam probably caused hysteria
Authors: K. P West
Journal: BMJ (2002)

EDITOR—Did the recent campaign to distribute vitamin A in Assam, India, cause an epidemic of illness or hysteria? The public health science underlying vitamin A prophylaxis and the reports that emerged after the same-day dosing of some 2.5 million preschool children point to hysteria.

Firstly, did vitamin A kill a child the day after dosing, and up to 13 children the next week, as claimed (overdosage by a new, larger delivery cup is being cited as the cause)?1 Almost certainly …
Some Social and Forensic Aspects of Exhumation and Reinterment of Industrial Revolution Remains
Authors: E. J. Duff, J. S. Johnson
Journal: BMJ (1974)

The aetiological aspects of exhumed remains from two burial sites were examined using 1839 and 1879 as years of comparison. We tried to discover whether the sample of recovered remains was representative of those buried. The state of the remains varied according to the type of soil and coffin material in which they were buried. At the earlier date most deaths were caused by infectious lesions rather than degenerative ones and 76% of those who died were below employable age—whereas in 1879 the commonest causes of death were tuberculosis (“phthisis”) and bronchitis, and 42% died before they could be employed. The registration of deaths were recorded more accurately at the later date, and it was easier to build up a picture of the age, sex, and occupation of the people who died.
Microbiological Studies on a New Broad-spectrum Penicillin, "Penbritin"
Authors: G. N. Rolinson, S. Stevens
Journal: BMJ (1961)

Suirrey' Penbritin " (B.R.L. 1341) is a new penicillin prepared from 6-aminopenicillanic acid.It is of special interest because it is acid-stable and is active against a wide range of Gram-positive and Gram-negative bacteria.The compound is 6[D(-)a-aminophenylacetamido]penicillanic acid, with the structural formula S CH.CO.NH.CH-CH C K\CH3 NH2 CO-N-CH.COOHAs the free acid it is sparingly soluble in water, and at neutral pH the solubility is only about 10%, at room temperature.