tbuckley/cabot-search huggingface dataset:
Workplace bullying in junior doctors: questionnaire survey
Authors: L. Quine
Journal: BMJ (2002)

sion incident in 1996, owing to logistical difficulties.Two units mentioned difficulties in tracking patients who had been referred to general practice; one unit reverted to immunisation through dialysis services rather than primary care after seroconversion of a patient who had been referred.Six units mentioned costs and funding as barriers.One unit thought our survey would encourage provision of funding.We thank all UK renal units who completed the study questionnaire and the staff at the Communicable Disease Surveillance Centre, Birmingham Heartlands Hospital.Contributors: SS and JH had the original
Report highlights patchy quality of US health care
Authors: L. Eaton
Journal: BMJ (2002)

The quality of health care in the United States—which arguably provides some of the best health care in the world—is not necessarily as good as it seems, according to a report from an adviser to the Nuffield Trust.

Professor Sheila Leatherman's report, edited by Douglas McCarthy and published by the New York based Commonwealth Fund, highlights the lack of preventive care, medical mistakes, substandard care for chronic conditions, and disparities in care.

It also indicates that the widespread misuse of antibiotics for conditions such as sore throat has led to the emergence of new strains of bacteria that are resistant to treatment with antibiotics. Throughout most of the 1990s the annual percentages of patients visiting their doctor with a …
Fecal Eosinophil-derived Neurotoxin Is Significantly Elevated In Non-ige Dependent Gastrointestinal Allergies, Especially In Subtypes Showing Bloody Stool
Authors: H. Morita, I. Nomura, T. Shoda, H. Saito, K. Matsumoto
Journal: Journal of Allergy and Clinical Immunology (2012)
Noninvasive Multiparametric Imaging of Metastasis-Permissive Microenvironments in a Human Prostate Cancer Xenograft
Authors: Marie-France Penet, Arvind P. Pathak, Venu Raman, Paloma Ballesteros, Dmitri Artemov, Zaver M. Bhujwalla
Journal: Cancer Research (2009)

Metastasis continues to be one of the major causes of mortality from prostate cancer. Because human malignant cell lines metastasize more readily from orthotopic sites than from heterotopic sites, to identify metastasis-permissive tumor microenvironments, we used noninvasive imaging to compare the in vivo vascular, metabolic, and physiologic characteristics of a human prostate cancer xenograft implanted orthotopically in the prostate or s.c. in the flank. Hypoxia was detected in these xenografts by placing an enhanced green fluorescence protein optical reporter under the control of a hypoxia response element. A multiparametric analysis of hypoxia, extracellular pH, vascularization, and metabolism provided a characterization of environments that are permissive for metastasis to occur. We found that orthotopic tumors, which metastasized more easily, were characterized by higher vascular volume, permeability, and total choline and a more acidic extracellular pH. Interestingly, metastatic deposits in the lymph nodes as well as cancer cells in ascites fluid were found to be hypoxic, explaining, in part, the refractory nature of metastatic disease. These results also provide the basis for clinically translatable noninvasive imaging markers for predicting metastatic risk in prostate cancer.
High penetrance, overweight, and glucocorticoid receptor variant: case-control study
Authors: R. C Y Lin, W. Y S Wang, B. J Morris
Journal: BMJ (1999)

A possible link between the glucocorticoid receptor gene ( GRL , 5q31-q32) and overweight has been suggested in a study of 42 families with morbid obesity.1 Data from another small study—of pairs of siblings—although not significant, showed a trend towards similar body mass index (weight(kg)/(height(m)2); difference=2.4) for 20 pairs sharing similar alleles compared with 19 pairs having discordant alleles (difference=3.5).2 An Asn363Ser variant, caused by a single nucleotide difference (A1218G) in exon 2 of GRL has since shown an association with increased sensitivity to glucocorticoids.3 Because of the predisposition to a rise in body mass index that this increased sensitivity should cause, we tested this variant for association with overweight in two groups of non-diabetic white subjects of British descent.

All participants lived in or near Sydney and …
Therapy of "Felty's Syndrome"
Authors: P. Ellman, L. Cudkowicz, J. S. Elwood
Journal: Annals of the Rheumatic Diseases (1955)

The incidence of normocytic hypochromic anaemia in rheumatoid disease is very high (Nilsson, 1948; Empire Rheumatism Council Scientific Advisory Committee, 1950; Jeffrey, 1952); while its aetiology is obscure, its severity appears to fluctuate with exacerbations of joint swellings (Kahlmeter, 1922; Nilsson, 1948).Occasionally the anaemia has the additional feature of a severe leucopenia, and if this becomes associated with progressive arthritis and splenomegaly, as was first noted by Chauffard and Ramond (1896), the clinical syndrome described by Felty (1924) emerges.This symptom complex is comparatively rare and has only been seen three times in this unit during the last 3 years.The reports in the literature of "Felty's syndrome" similarly comprise only small series (Singer and Levy,
The ultrastructure of fibronectin fibers pulled from a protein monolayer at the air-liquid interface and the mechanism of the sheet-to-fiber transition
Authors: Maria Mitsi, Stephan Handschin, Isabel Gerber, Ruth Schwartländer, Enrico Klotzsch, Roger Wepf, Viola Vogel
Journal: Biomaterials (2014)

Fibronectin is a globular protein that circulates in the blood and undergoes fibrillogenesis if stretched or under other partially denaturing conditions, even in the absence of cells.Stretch assays made by pulling fibers from droplets of solutions containing high concentrations of fibronectin have previously been introduced in mechanobiology, particularly to ask how bacteria and cells exploit the stretching of fibronectin fibers within extracellular matrix to mechano-regulate its chemical display.Our electron microscopy analysis of their ultrastructure now reveals that the manually pulled fibronectin fibers are composed of densely packed lamellar spirals, whose interlamellar distances are dictated by ion-tunable electrostatic interactions.Our findings suggest that fibrillogenesis proceeds via an irreversible sheet-tofiber transition as the fibronectin sheet formed at the air-liquid interface of the droplet is pulled off by a sharp tip.This far from equilibrium process is driven by the externally applied force, interfacial surface tension, shear-induced fibronectin self-association, and capillary force-induced buffer drainage.The ultrastructural characterization is then contrasted with previous FRET studies that characterized the molecular strain within these manually pulled fibers.Particularly relevant for stretch-dependent binding studies is the finding that the interior fiber surfaces are accessible to nanoparticles smaller than 10 nm.In summary, our study discovers the underpinning mechanism by which highly hierarchically structured fibers can be generated with unique mechanical and mechano-chemical properties, a concept that might be extended to other bio-or biomimetic polymers.
Gray platelet syndrome. Dissociation between abnormal sorting in megakaryocyte alpha-granules and normal sorting in Weibel-Palade bodies of endothelial cells.
Authors: J Gebrane-Younès, E M Cramer, L Orcel, J P Caen
Journal: Journal of Clinical Investigation (1993)

The gray platelet syndrome (GPS) is a rare congenital bleeding disorder in which megakaryocytes and platelets are deficient in alpha-granule secretory proteins. Since the Weibel-Palade bodies (WPB) of endothelial cells as well as the alpha-granules contain the von Willebrand Factor (vWF) and P-selectin, we examined by transmission electron microscopy the dermis capillary network of two patients with GPS. Endothelial cells showed the presence of normal WPB with typical internal tubules. Using single and double immunogold labeling for vWF and P-selectin, we detected vWF within WPB, where it was codistributed with the tubules, whereas P-selectin delineated the outline of WPB. Therefore, the fundamental targeting defect in GPS is specific to the megakaryocytic cell line.
Staging Lung Carcinoma with a Tc-99m Labeled Monoclonal Antibody
Authors: JOHNATHAN P. VANSANT, DAVID H. JOHNSON, DENNIS M. OʼDONNELL, JAMES R. STEWART, ANDREW H. SONIN, BARRY M. McCOOK, THOMAS A. POWERS, DARRELL J. SALK, WILLIAM H. FRIST, MARTIN P. SANDLER
Journal: Clinical Nuclear Medicine (1992)

Thirty-three patients with biopsy-proven lung cancer and a total of 150 lesions diagnosed by conventional staging procedures were imaged using a Tc-99m labeled monoclonal Fab fragment of an lgG2B murine monoclonal antibody (MoAb) (NR-LU-10, NeoRx Corporation). Immunoscintigraphy demonstrated 100% of primary and 78% of metastatic lesions. MoAb imaging detected 88% of lesions in 12 small cell lung cancer (SCLC) patients and 77% of lesions in 21 non-small cell lung cancer (NSCLC) patients. Based on initial evaluation by other methods, 29 sites of MoAb activity were not associated with evidence of disease. Eleven of these were subsequently shown to represent sites of metastases; 18 remain unconfirmed. Four of ten patients studied with limited NSCLC had eight unsuspected lesions on MoAb imaging. Confirmation of unsuspected lesions in two patients altered initial clinical staging, and surgical therapy was abandoned. This study demonstrates that Tc-99m labeled NR-LU-10 can accurately stage patients with lung cancer.
Diphosphonate Intestinal Activity Seen on Two Bone Images in Neuroblastoma
Authors: KEVIN K. McCARTHY, SYDNEY HEYMAN
Journal: Clinical Nuclear Medicine (1986)

Neuroblastoma is well recognized as a cause of soft tissue uptake of Tc-99m MDP. Two cases of neuroblastoma arising in the midline from the celiac axis are reported. Bone imaging performed on two separate days showed not only typical soft tissue uptake, but also the appearance of the radiopharmaceutical in the bowel. At surgery, a midline upper abdominal neuroblastoma was found in both patients without evidence of involvement of the liver, kidneys, bowel, gallbladder or mesentery. It became apparent with delayed images in the second patient that this activity was in the bowel and moving around the abdomen in a typical large bowel pattern. Bowel activity was not seen in other patients having bone scans at this time. Follow-up bone imaging on the first patient after resection of the tumor did not demonstrate diphosphonate activity in the bowel. These authors have never seen or read of this finding previously in this condition, and report it in these two patients.
Family Nurse Practitioners for Internists in Primary Care.
Authors: Robert B. Chevalier
Journal: Annals of Internal Medicine (1973)

Meeting Abstracts1 May 1973Family Nurse Practitioners for Internists in Primary Care.Robert B. Chevalier, M.D., F.A.C.P., Shirley A. Ross, R.N., Beverly C. Flynn, Ph.D.Robert B. Chevalier, M.D., F.A.C.P.Search for more papers by this author, Shirley A. Ross, R.N.Search for more papers by this author, Beverly C. Flynn, Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-5-835_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe Family Nurse Practitioner Program at the Indiana University Schools of Medicine and Nursing is one of seven new programs designed to train registered nurses to assume greater responsibility in primary care practice. Sixteen nurses completed the 6-month training program in December 1972 and are practicing with internists, pediatricians, and family practitioners. The 3-month didactic portion of the program at the University Medical Center consists of lectures, demonstrations, and clinic experience in medicine, pediatrics, obstetrics-gynecology, psychiatry, and surgery and an intensive physical diagnosis course. Trainees then spend 3 months in an office setting with preceptors; each student works with three... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Robert B. Chevalier, M.D., F.A.C.P.; Shirley A. Ross, R.N.; Beverly C. Flynn, Ph.D.Affiliations: Indianapolis, Indiana. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1973Volume 78, Issue 5Page: 835-835KeywordsNursesPediatric surgeryPediatrics ePublished: 1 December 2008 Issue Published: 1 May 1973 PDF downloadLoading ...
Thymectomy in Systemic Lupus Erythematosus
Authors: I. R. Mackay, G. Goldstein, I. H. McConchie
Journal: BMJ (1963)

PARAPLEGIAweeks after treatment and in two patients the urinary K. aerogenes infection persisted throughout treatment.In both these cases the organism showed the same in-vitro sensitivity before and after treatment.
Intracellular delivery of liposome-encapsulated prolidase in cultured fibroblasts from prolidase-deficient patients
Authors: Paola Perugini, Khaolé Hassan, Ida Genta, Tiziana Modena, Franca Pavanetto, Giuseppe Cetta, Chiara Zanone, Paolo Iadarola, Annalia Asti, Bice Conti
Journal: Journal of Controlled Release (2004)
Coronary Cinearteriography for Recognition of "Demand" for Collateral Arteries
Authors: William H. Sewell
Journal: JAMA (1963)

THE RECOGNITION of a physiological "demand" for collateral arteries by the coronary arterial system is becoming of practical clinical importance, because of the recent demonstration of collateral channels to coronary arteries in patients after the Vineberg internal mammary implantation,<sup>1, 2</sup>and after implantation of a pedicle containing the internal mammary artery, vein, adjacent connective tissue, and muscle in an incision in the left ventricular wall.<sup>3</sup>The fact that collateral arterial channels can be expected to develop only to an area of tissue with inadequate arterial supply is well established, and operations designed to cause collateral channels to develop to coronary arteries logically should be performed only on patients who have this situation in an accessible portion of the myocardium. Experiments have been performed in animals to obtain basic information that could be used in establishing reasonable clinical criteria for the use of the procedure in humans.<sup>4,</sup>
Developmental differences in megakaryocytopoiesis are associated with up-regulated TPO signaling through mTOR and elevated GATA-1 levels in neonatal megakaryocytes
Authors: Zhi-Jian Liu, Joseph Italiano, Francisca Ferrer-Marin, Ravi Gutti, Matthew Bailey, Brandon Poterjoy, Lisa Rimsza, Martha Sola-Visner
Journal: Blood (2011)
Efficacy of local dipyridamole therapy in a porcine model of arteriovenous graft stenosis
Authors: T. Kuji, T. Masaki, K. Goteti, L. Li, S. Zhuplatov, C.M. Terry, W. Zhu, J.K. Leypoldt, R. Rathi, D.K. Blumenthal, S.E. Kern, A.K. Cheung
Journal: Kidney International (2006)
The Opium Shortage: Politics and Health
Authors: Joseph Cochin
Journal: New England Journal of Medicine (1975)

In December of last year an editorial appeared in the Journal 1 that delineated the problems arising from the ill conceived and ill fated venture of the Nixon administration into the control of the production of Papaver somniferum, the opium poppy. The most far-reaching consequence of this policy was to create an artificial shortage and increased prices of the natural alkaloids and their derivatives, used by physicians in the country for analgesic, antitussive, and antidiarrheal purposes. According to best estimates made at a workshop held in conjunction with the 1975 meeting of the National Academy of Sciences-National Research Council Committee on . . .
956 IMPROVED DETECTION OF HCC BY CO-DETERMINATION OF IGM ANTI-AFP ANTIBODIES AND AFP-IGM IMMUNE COMPLEXES
Authors: C. Gomiero, P. Pengo, A. Gallotta, A. Biasiolo, N. Tono, A. Gatta, P. Pontisso, C. Matteucci, G. Fassina, L. Beneduce
Journal: Journal of Hepatology (2011)
Mechanical strain and collagen potentiate mitogenic activity of angiotensin II in rat vascular smooth muscle cells.
Authors: K Sudhir, E Wilson, K Chatterjee, H E Ives
Journal: Journal of Clinical Investigation (1993)

The effects of extracellular matrix proteins and mechanical strain on the mitogenic activity of angiotensins I and II (AI and AII) were examined in cultured rat vascular smooth muscle (VSM) cells. VSM cells on various extracellular matrices were exposed to AII (1 microM) for 48 h. On plastic, AII induced only a 1.6-fold increase in [3H]thymidine incorporation, but on fibronectin- or type I collagen-coated plastic, the response to AII was enhanced from two- to fourfold. On a type I collagen-coated silicone elastomer, to which mechanical strain was applied, [3H]thymidine incorporation dramatically increased to a maximum of 53-fold. Dup 753 (10(-5) M) blocked the AII-induced increase in DNA synthesis. AI also increased DNA synthesis in VSM cells, and this response was also enhanced by mechanical strain. Mitogenic activity of AI was blocked by ramiprilat (10(-5) M), indicating that its mitogenic activity was via conversion to AII. The synergy between AII and strain was completely eliminated by neutralizing antibodies to PDGF AB (3 micrograms/ml). Furthermore, the mitogenic effect of AII in unstrained cells was also synergistic with submaximal concentrations of PDGF AB (1 ng/ml). Thus, the synergy between AII and mechanical strain probably results from synergism between AII and PDGF secreted in response to strain.
Endotoxin-induced hydrogen peroxide production in intact pulmonary circulation of rat.
Authors: Y Minamiya, S Abo, M Kitamura, K Izumi, Y Kimura, K Tozawa, S Saito
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

Although the importance of free oxygen radical has been reported in acute lung injury, the direct evidence in vivo model was lacking. We report a new method, which for the first time allows direct detection of hydrogen peroxide in the intact rat pulmonary microcirculation. We used the computer image-analyzing system and 2',7'-dichlorofluorescin diacetate for the marker of hydrogen peroxide production in vivo. A rat sepsis model was produced by continuous infusion of endotoxin for 30, 60, and 120 min. Hydrogen peroxide production in the pulmonary microcirculation of the sepsis rat was higher than in the control rat at each time point (p < 0.01) and increased time-dependently (p < 0.01). Catalase (5,000 U/kg) almost completely inhibited the hydrogen peroxide production in the sepsis rat (p < 0.01). In high-power view, hydrogen peroxide was detected in granulocytes that adhered to the capillaries and endothelial cells that were adjoining adherent granulocytes. These observations suggest that hydrogen peroxide in the endothelium was diffused from granulocytes. In this study, we demonstrated direct evidence of hydrogen peroxide production from adherent granulocytes in intact rat lung treated with endotoxin. We conclude that endotoxin causes the granulocyte adhesion and oxidative stress to the endothelium due to adherent granulocytes within 30 min in the pulmonary microcirculation.
CD30+ reversible lymphoid dyscrasia (pseudolymphoma) following HIDA scintigraphy and the [Ring1]-[Ring2]-[C=O] generalized structure hypothesis
Authors: Ryan K. Rader, William V. Stoecker, Kristen A. Hinton, Janine C. Malone, Thomas P. Schuman
Journal: Journal of the American Academy of Dermatology (2013)
Prone MammoPET Acquisition Improves the Ability to Fuse MRI and PET Breast Scans
Authors: Linda Moy, Marilyn E. Noz, Gerald Q. Maguire, Fabio Ponzo, Abby E. Deans, Antoinette D. Murphy-Walcott, Elissa L. Kramer
Journal: Clinical Nuclear Medicine (2007)

This study compared prone acquisition of PET scans with traditional supine acquisition to improve fusion of PET scans with MRI scans and improve evaluation of enhancing breast lesions detected on MRI.MRI breast scans are acquired in the prone position using a breast coil to allow the breasts to hang pendant. An apparatus was fabricated to allow prone acquisition of PET scans. Fused scans from 2 patients acquired both prone and supine were contrasted with those from 3 patients acquired supine only. All 5 MRI scans were acquired on standard scanners. The PET scans were acquired with a PET/CT unit using a low-dose CT scan for attenuation correction. The PET and MRI volumes were matched twice (using a semiautomated registration method) by different operators. The additional value of fusion was judged using reports from the original (nonfused) MRI and PET, joint rereading of the volumes side by side, and examination of fused images.Of 12 enhancing lesions on breast MRI, 7 demonstrated uptake on PET/CT. In the 3 supine-only cases, the fused images were not interpretable because of the marked distortion of the breasts. In the 2 prone cases, the fused images increased our confidence in characterizing a lesion as benign or malignant. Interpretations were confirmed by clinical follow up in 2 or histologic results in 3 patients.PET MRI fusion is feasible and may assist in localizing lesions detected on either study. A more extensive study is underway to confirm the value of this fusion technique.
Abstract 1265: RbBP6 Isoform 3 (DWNN) is a p53 stabilizer in arsenic trioxide-induced apoptosis in human cancer cell lines
Authors: Zodwa Dlamini, Zukile Mbita, Amanda Skepu, David Pugh, Jasper Rees, Mervin Meyer
Journal: Cancer Research (2010)

Abstract Domain With No Name (DWNN) has a ubiquitin-like fold and shares 22% similarity with ubiquitin. This suggests its significant importance in cell homeostasis and protein degradation in a human body. The presence of a ubiquitin-like fold suggests a role similar to ubiquitin and RbBP6 may be involved in ubiquitin ligase-like activities. Furthermore RbBP6 interacts with both p53 and pRb which are key components of cell cycle regulation. These two tumour suppressors are key to the understanding the function of the RbBP6. It has been found that upon arsenic trioxide-induced treatment RbBP6 isoform 3 (DWNN) is up-regulated. In this study the role of the DWNN on p53-dependent apoptosis was investigated. Over-expressions of RbBP6 isoforms was achieved by transfection of recombinant isoforms using Metafectene Easy. Apoptosis was induced using arsenic trioxide and staurosporine. Apoptosis was then measured using APOPercentage and flow cytometry. The expression of RbBP6 gene products and p53 was determined using both real-time PCR and western blotting. Up-regulation of RbBP6 was observed in As2O3-induced apoptosis in cancer cells. Over-expression of the RbBP6 isoform 1 intensified As2O3-induced apoptosis. MTT assay showed an IC50 of 40µM for As2O3. When this concentration was used to induce apoptosis in human cancer cells and this resulted in induced expression of RbBP6 isoform 1 not the isoform 3. Over-expression of RbBP6 isoform 3 though resulted in stabilization of p53 protein. The apoptosis that was observed was also accompanied by the expression of p53. This study suggests that the DWNN may not be directly involved in the prosecution of apoptosis but may be involved through p53 stabilization. This study suggests that the RbBP6 may be a p53 stabilizer in contrast to mdm2, which is a negative regulator of p53. It will be very important to also determine the relationship between RbBP6 and pRb in both cell cycle and apoptosis Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1265.