Hypertension and Retinopathy in Waldenström's Macroglobulinemia
Authors: KLAUS P. SCHMIDT
Journal: Annals of Internal Medicine (1965)

Case Studies1 November 1965Hypertension and Retinopathy in Waldenström's MacroglobulinemiaKLAUS P. SCHMIDT, M.D., JOHN R. CALDWELL, M.D., F.A.C.P., DANIEL H. BASINSKI, PH.D., GERALD FINE, M.D.KLAUS P. SCHMIDT, M.D.Search for more papers by this author, JOHN R. CALDWELL, M.D., F.A.C.P.Search for more papers by this author, DANIEL H. BASINSKI, PH.D.Search for more papers by this author, GERALD FINE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-5-842 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn recent years cases of Waldenström's macroglobulinemia associated with rather striking characteristic eyeground changes have been reported in the literature. We feel that the practicing internist should be aware of these changes because they may give an immediate clue to a sometimes puzzling diagnosis.The case reported here had, in addition to this characteristic funduscopic picture, three other unusual features; namely, hypertension, rarely seen in Waldenström's macroglobulinemia, a very high prothrombin time, and a bizarre finding on autopsy of casting of the cardiovascular system by coagulated plasma.CASE REPORTA 52-year-old white machinist was brought to the Emergency Room in...References1. DUTCHERFAHEY TFJL: The histopathology of the macroglobulinemia of Waldenström. J. Nat. Cancer Inst. 22: 887, 1959. CrossrefMedlineGoogle Scholar2. WALDENSTRÖM J: Incipient myelomatosis or "essential" hyperglobulinemia with fibrinogenopenia—new syndrome? Acta Med. Scand. 117: 216, 1944. CrossrefGoogle Scholar3. ANDERSSONSAMUELSON BA: Case of hyperglobulinemia with pronounced eye changes and acrocyanosis. Ibid., p. 248. Google Scholar4. RITZMANNTHURMTRUAXLEVIN SERHWEWC: The syndrome of macroglobulinemia. Review of the literature and a report of two cases of macroglobulinemia. Arch. Intern. Med. (Chicago) 105: 939, 1960. CrossrefMedlineGoogle Scholar5. SCHULTENKANZOW HU: Makroglobulinamie (Waldenström'sche Krankheit). Folia Haemat. (Frankfurt) 1: 49, 1956. MedlineGoogle Scholar6. BERNEAUD-KÖTZJAHNKE GK: Über einen Fall von ungewöhnlicher Dys-und paraproteinämie mit auffallenden augenintergrundveränderungen (fundus paraproteinaemicus). Klin. Mbl. Augenheilk. 125: 160, 1954. Google Scholar7. CAGIANUTHOFFMANN-EGG BL: Über Augenhintergrundsveränderungen bei makroglobulinämien. Graefe Arch. Ophthal. 153: 391, 1953. CrossrefMedlineGoogle Scholar8. DANISBRAUMANCOPPEZ PJP: Les lesions du fond d'oeil au cours de certaines hyperproteinemies (myelelome a cryoglobuline macroglobulineme. Acta Ophthal. (København) 33: 33, 1955. CrossrefMedlineGoogle Scholar9. COYLEFRANKLEONARDWEINER JTPEALA: Macroglobulinemia and its effect upon the eye. Arch. Ophthal. (Chicago) 65: 75, 1961. CrossrefMedlineGoogle Scholar10. WINTROBEBUELL MMMV: Hyperproteinemia associated with multiple myeloma. Bull. Hopkins Hosp. 52: 156, 1933. Google Scholar11. BICHELBINGHARBOE JJN: Another case of hyperglobulinemia and affection of central nervous system. Acta Med. Scand. 138: 1, 1950. CrossrefMedlineGoogle Scholar12. CHAMBERSZWEIFACH RBW: Intercellular cement and capillary permeability. Physiol. Rev. 27: 436, 1947. CrossrefMedlineGoogle Scholar13. KNISELYBLOCHELIOTWARNER MHEHTSL: Sludged blood. Trans. Amer. Ther. Soc. 48: 95, 1948. Google Scholar14. BERNEAUD-KÖTZ G: Zur Pathophysiologie extremer Paraproteinaemien. Verh. Deutsch. Ges. Inn. Med. 66. Kongress, 1960, Verlag J. F. Bergmann, Munich, pp. 512-515. Google Scholar15. BERNEAUD-KÖTZNOVER GA: Klinische und experimentelle Beobachtungen über Augenveränderungen bei der Makroglobulinämie Waldenström. Klin. Wschr. 35: 472, 1957. CrossrefMedlineGoogle Scholar16. BERNEAUD-KÖTZLIEBEGOTT GG: Zur Histologie der Augenveränderungen bei der Makroglobulinämie Waldenstroem. Ber. d. 65. Zus. Kunft der Deutsch. Ophthal. Ges. in Heidelberg, 1963, Verlag J. F. Bergmann, Munich, pp. 512-515. Google Scholar17. PACHTERJOHNSONNEBLETT MRSATR: Bleeding, platelets and macroglobulinemia. Amer. J. Clin. Path. 31: 467, 1959. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: KLAUS P. SCHMIDT, M.D.; JOHN R. CALDWELL, M.D., F.A.C.P.; DANIEL H. BASINSKI, PH.D.; GERALD FINE, M.D.Affiliations: Detroit, MichiganFrom the Division of Hypertension and Department of Pathology, Henry Ford Hospital, Detroit, Mich.Requests for reprints should be addressed to John R. Caldwell, M.D., Division of Hypertension, Henry Ford Hospital, Detroit, Mich. 48202. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1965Volume 63, Issue 5Page: 842-850KeywordsAutopsyBlood plasmaEmergency departmentHypertensionLesionsProthrombin timeRetinopathyUltracentrifugation ePublished: 1 December 2008 Issue Published: 1 November 1965 PDF downloadLoading ...