tbuckley/cabot-search huggingface dataset:
Socioeconomic Status Is an Important Determinant of the Use of Invasive Procedures After Acute Myocardial Infarction in New York State
Authors: E. F. Philbin, P. A. McCullough, T. G. DiSalvo, G. W. Dec, P. L. Jenkins, W. D. Weaver
Journal: Circulation (2000)

Patient and hospital characteristics influence the use of invasive cardiac procedures. Whether socioeconomic status (SES) has an influence that is independent of these other determinants is unclear. The purpose of the present study was to examine the influence of household income as a measure of SES on the use of invasive cardiac procedures among a large group of patients with acute myocardial infarction.We analyzed administrative discharge data from 231 nonfederal acute care hospitals in New York State that involved 28 698 black or white inpatients with International Classification of Diseases, Ninth Revision, Clinical Modification code 410.XX in the principal diagnosis position between January 1 and December 31, 1995. Household income was derived from postal ZIP codes and census data. The use of cardiac catheterization, PTCA, CABG, and any revascularization procedure was examined across groups stratified by income. Patients who resided in lower-income neighborhoods were more often female or black, had a higher prevalence of coexistent illness, had a higher use of Medicaid insurance, and were less often admitted to urban hospitals or hospitals that provide on-site CABG and PTCA. Crude and adjusted odds ratios for catheterization, PTCA, CABG, and any revascularization procedure were related to income in a graded fashion. After adjustment, patients in the highest quintile of income were 22% more likely to undergo catheterization, 74% more likely to undergo PTCA, 48% more likely to undergo CABG, and 76% more likely to undergo any revascularization procedure than were patients in the lowest quintile. The difference in cardiac catheterization did not fully account for income-based differences in revascularization, because income remained a significant determinant of revascularization after accounting for whether a catheterization was performed. Even among patients treated in hospitals that provide on-site CABG and PTCA, income was a significant determinant of procedures.Lower-income patients hospitalized for acute myocardial infarction are more often female or black, have more coexisting illnesses, and are less often admitted to urban hospitals or hospitals that provide CABG and PTCA. Even after adjustment for these and other factors, lower income is a negative predictor of procedure use.
Effective treatment of Wilson's disease with oral zinc sulphate: two case reports.
Authors: T U Hoogenraad, C J Van den Hamer, J Van Hattum
Journal: BMJ (1984)

Most patients with Wilson9s disease are treated with the potentially toxic cupriuretic agent penicillamine. The toxicity of zinc taken by mouth is low, and long term administration induces a negative copper balance. Two patients with severe neurological symptoms were given zinc sulphate by mouth three times daily in doses of 200 mg, later increased to 300 mg. One patient, a 21 year old man, started to receive zinc sulphate after his condition had deteriorated during treatment with cupriuretic drugs. The other, a 27 year old woman, was treated from the start with zinc sulphate. The conditions of both patients improved appreciably, and they were still receiving treatment with zinc sulphate roughly two years later. Effective depletion of body copper stores was shown by an intravenous radiocopper loading test and liver biopsy. No side effects were found. Wilson9s disease may effectively be treated with zinc sulphate alone.
PULSATING ABSCESS OF CHEST WALL SIMULATING ANEURYSM
Authors: George Kahn
Journal: JAMA (1924)

The diagnosis of aneurysm is so easily and so certainly made when one sees a pulsating area of bulging in the precordial region, and with such a high percentage of later confirmation, that such a case in which the diagnosis of aneurysm was wrong is worth reporting. A colored hod-carrier, aged 27, ten months before entry began to have severe, steady pains in the lower right back and axilla, at times also in the left lower axilla. With this there was loss of appetite and weight, no cough, and no definite history of fever. He was admitted to the Boston City Hospital and was discharged slightly improved two months later with a questionable diagnosis of nephrolithiasis of the right kidney, no evidence for tuberculosis having been made out. He continued in this condition under his local physician's care without improvement until two months before admission, when he began to have
LOCAL ANESTHESIA IN THE REDUCTION OF FRACTURES OF THE LOWER FOREARM
Authors: CARL O. RICE
Journal: JAMA (1928)

Local anesthesia was first used for the reduction of fractures in 1885 by Conway.<sup>1</sup>He reported three cases of Colles' fracture and one of posterior dislocation of both bones of the elbow reduced under cocaine anesthesia with good results. Then Lerda,<sup>2</sup>in 1907, and Quénu,<sup>3</sup>in 1908, injected cocaine into the fragmented ends so that the bone marrow, periosteum and surrounding tissue were infiltrated. They reported favorable results and recommended its use more extensively. In 1913, Dollinger<sup>4</sup>and Braun,<sup>5</sup>working independently, reported having used procaine hydrochloride anesthesia both by local infiltration around and into the fragments of the bone and by circular conduction anesthesia. Both these men were of the opinion that the circular conduction method was the better, but recognized certain advantages of the local infiltration method, as in fractures of the clavicle and ribs, in which a nerve block could not be accomplished.
An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains
Authors: Johanna Aaltonen, Petra Björses, Jaakko Perheentupa, Nina Horelli–Kuitunen, Aarno Palotie, Leena Peltonen, Yeon Su Lee, Fiona Francis, Steffen Henning, Cora Thiel, Hans Leharach, Marie–Laure Yaspo
Journal: Nature Genetics (1997)
Medical Mystery: A 71-Year-Old Man with Pancytopenia — The Answer
Authors: Julia M. Braza, Parul Bhargava
Journal: New England Journal of Medicine (2008)

To the Editor: The medical mystery in the October 30 issue1 concerned a 71-year-old man with a 10-day history of dizziness, progressive lethargy, and confusion. A complete blood count showed pancytopenia (white-cell count, 2900 per cubic millimeter [normal range, 4000 to 11,000]; hemoglobin, 5.5 g per deciliter [normal range, 14 to 18]; hematocrit, 14.5% [normal range, 40 to 52]; and platelets, 56,000 per cubic millimeter [normal range, 150,000 to 440,000]) as well as macrocytosis (mean cell volume, 118 μm3 [normal range, 82 to 98], with a red-cell distribution width of 22,300 per cubic millimeter [normal range, 10,500 to 15,500]) and . . .
Guidelines for the management of tinea capitis
Authors: E.M. Higgins, L.C. Fuller, C.H. Smith
Journal: British Journal of Dermatology (2000)

These guidelines for the management of tinea capitis have been prepared for dermatologists on behalf of the British Association of Dermatologists. They present evidence-based guidance for treatment, with identification of the strength of evidence available at the time of preparation of the guidelines, and a brief overview of epidemiological aspects, diagnosis and investigation.
Golgi: A Biography of the Founder of Modern Neuroscience
Authors: Douglas Lanska
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Myeloid cell surface phenotype in myelodysplasia: Evidence for abnormal persistence of an early myeloid differentiation antigen
Authors: Michael A. Baumann, Robert H. Keller, Patrick W. McFadden, Joseph A. Libnoch, Catherine W. Patrick
Journal: American Journal of Hematology (1986)

Abstract A panel of monoclonal antibodies recognizing myeloid cell surface differentiation‐associated antigens was used to study the peripheral blood myeloid population of 23 patients with myelodysplastic syndromes (MDS) and 23 controls. A marker for immaturity, defined by the presence of the antigen recognized by the My9 antibody, was found to persist on the surface of mature neutrophils in a subgroup of MDS patients. Abnormal My9 positivity was concentrated primarily, but not exclusively, in previously described morphologically defined subgroups of MDS patients considered to be at highest risk for leukemic conversion. Longitudinal study of a larger number of patients will be required to test the hypothesis that abnormal persistence of My9 may have prognostic significance.
NEGATIVE T WAVES AFTER REPERFUSED MYOCARDIAL INFARCTION ARE A MARKER OF MYOCARDIAL STUNNING AND PREDICT REGIONAL RECOVERY OF CONTRACTILE FUNCTION
Authors: Gaetano Maria De Ferrari, Alessandra Greco, Antonio Sanzo, Claudia Raineri, Annalisa Turco, Mara Bonardi, Fabio Badilini, Martino Vaglio
Journal: Journal of the American College of Cardiology (2011)
Association of Mite-Specific IgE Level with Th2-Shifted Response of Peripheral Blood Mononuclear Cells to Stimulation with Mite Allergen and Airway Hyperresponsiveness in Children Sensitized to Mite
Authors: S.I. Woo, J.S. Lim, Y.S. Hahn
Journal: Journal of Allergy and Clinical Immunology (2009)
Lipoid Granulomata in Scalene Node
Authors: T. F. C. S. WARNER
Journal: Annals of Internal Medicine (1976)

Comments and Corrections1 June 1976Lipoid Granulomata in Scalene NodeT. F. C. S. WARNER, M.D.T. F. C. S. WARNER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-84-6-755_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Varkey and Kutty (1) suggest that the finding of mineral oil in a scalene node biopsy may aid in the diagnosis of lipoid pneumonia. Although aspirated mineral oil may well reach these lymph nodes, its mere demonstration does not prove entry via the respiratory tract. Oil-laden macrophages are commonly found in lymph nodes, spleen, and less commonly in liver and bone marrow of adults. Kelsall and Blackwell (2) found lipophage clusters in scalene lymph nodes in 12 of 279 patients at autopsy. The association of black pigment with oil vacuoles does not appear to be helpful either....References1. VARKEYKUTTY BA: Lipoid pneumonia with lipoid granulomata in scalene node. Ann Intern Med 84:176-177, 1976 LinkGoogle Scholar2. KELSALLBLACKWELL GJ: The occurrence and significance of lipophage clusters in lymph nodes and spleen. Pathology 1: 211-220, 1969 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Research Hematology Mayo Clinic Rochester, MN 55901 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1976Volume 84, Issue 6Page: 755-755KeywordsAutopsyBiopsyBone marrowLiverLymph nodesOilsPneumoniaRespiratory systemSpleen Issue Published: 1 June 1976 PDF DownloadLoading ...
The Good Body
Authors: Chloe Veltman
Journal: BMJ (2004)

Written and performed by Eve Ensler Directed by Peter Askin American Conservatory Theater, San Francisco, California, United States, until 1 August 2004 http://act-sf.org/ Rating: ![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img> I n a darkened auditorium against a backdrop of loud gurgling and sucking sounds, a 35 year old woman lies on her back, talking about her latest cosmetic surgery procedure. It is the most recent in a long history of operations, which have included everything from liposuction to soy breast implants. Without a hint of irony, the woman says that she is in a sexual relationship with her plastic surgeon, a man who seems to regard himself as something of a Dr Frankenstein and his partner as his most fabulous creation. In recent years, cosmetic surgery has eked out a whole new … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif
EUS-guided retrieval of a migrated transgastric pancreatic stent
Authors: S. Varadarajulu
Journal: Endoscopy (2007)

Transmural drainage of pancreatic pseudocysts has become an accepted alternative to surgery when an intervention is indicated. The complications of the procedure mainly involve bleeding, perforation, stent dysfunction, or migration into the gastrointestinal lumen [1]. We report here on a technique with which a stent that had migrated into the pancreatic necrosis cavity was retrieved successfully under endoscopic ultrasound (EUS) guidance.
Doing something about tuberculosis
Authors: A. Zumla, J. M Grange
Journal: BMJ (1999)

The phenomenal success public health officials enjoyed in controlling tuberculosis (TB) in developed countries has not been mirrored in developing countries, where TB still accounts for 25% of preventable deaths in adults. The fact that there are 8 million new cases each year (95% in developing countries) and 3 million deaths (98% in developing countries) led to the 1993 declaration by the World Health Organization (WHO) that TB poses a global emergency. Because TB is predominantly a disease of impoverished people, indifference has led to the fallacious and naive view that eradication of TB simply requires socioeconomic development. In response to this indifference, the WHO is promoting a "Stop TB--Use DOTS" campaign. DOTS, a strategy based on directly observed therapy, also requires government commitment, a regular supply of drugs, effective diagnoses, and an audit of the efficacy of the strategy. While the treatment of TB is among the most cost-effective of all medical interventions in terms of years of healthy life saved, the DOTS campaign requires a considerable dedication of funds. Renewed interest in TB is leading the US and the UK to increase support for control programs. In addition, a new UK-based charity, "TB Alert," hopes to play a major role in advocating for political commitment to and funding for TB control.
Bible is disapproving of homosexual activity but not homosexual orientation
Authors: C. Wayte
Journal: BMJ (1999)

EDITOR—In his Personal View Sheard states that “most people have a relative or friend who is lesbian or gay.”1 This is incorrect and merely reflects the misconception that homosexuality is relatively common. In fact, it is very uncommon: the national survey on sexual behaviour in 1994 found that 0.4% of men considered themselves exclusively homosexual, as did 0.1% of women.2 Most people do not have …
Reactions of patients to video recording of consultations in general practice.
Authors: G Herzmark
Journal: BMJ (1985)

The potential value of video recording for examining medical consultations depends on the extent to which recordings are representative of unfilmed consultations. This paper examines the views of 295 patients in two general practices whose consultations were filmed and compares them with the views of a control group of 185 patients. Most of those who were filmed reported that the consultation was not directly affected, and no overall effect of filming was discovered when patients rated their stress after the consultations, their rapport with the doctor, or other aspects of the consultation. At one practice, however, filming was significantly associated with lower ratings of rapport between doctor and patient among those patients who reported some direct effect of filming. Patient refusal rates from other studies are also examined and shown to vary systematically--the more opportunity patients are given to decline the more likely they are to take it. Consideration of doctors' responses to being filmed would usefully complement the emphasis on the views of patients.
The Physician as an Expert Witness
Authors: Sidney Shindell
Journal: New England Journal of Medicine (1962)

THE chances are infinitely better than 50:50 that the average physician would reply to an invitation to appear in court with a polite refusal. Even when he has a personal or professional interest in a party to a lawsuit, the average practitioner of medicine is not anxious to consider becoming an active participant in a trial. Certainly, if there is the least degree of "sensitivity" or "controversy" about a lawsuit, the physician is most resistant to any possibility of "getting involved."A good portion of the reluctance of physicians to become witnesses is based on the popular abhorrence to having . . .
High positive predictive value of Xpert in a low rifampicin resistance prevalence setting
Authors: Anete Trajman, Betina Durovni, Valeria Saraceni, Marcelo Cordeiro-Santos, Frank Cobelens, Susan van den Hof
Journal: European Respiratory Journal (2014)

High positive predictive value of Xpert in a low rifampicin resistance prevalence settingTo the Editor:Although drug susceptible tuberculosis (TB) is a curable disease, spread of rifampicin-resistant TB, including multidrug-resistant (MDR)-and extensively drug-resistant (XDR)-TB, is a threat to disease control worldwide [1], in particular in Eastern Europe [2].XpertMTB/RIF (Xpert; Cepheid Inc., Sunnyvale, CA, USA) is an accurate [3] and affordable [4] automated PCR-based assay that detects DNA of Mycobacterium tuberculosis and resistance to rifampicin in ,2 h [5].While the World Health Organization (WHO) has endorsed the use of Xpert for TB diagnosis as a replacement for sputum smear examination [6], concerns have been raised about the low positive predictive value (PPV) of rifampicin-resistant Xpert results in patients who have never previously been treated for TB and in countries with a low prevalence of rifampicin-resistance and MDR-TB [5].WHO guidelines currently call for initiation of MDR-TB treatment with second-line drugs when resistance is repeatedly detected by Xpert, while confirmatory testing is performed [6].Xpert detects mutations in the M. tuberculosis rpoB gene, which is responsible for .95% of rifampicin resistance, with a well-established 98% specificity [3,7].Compared with the earlier version [3,7], the latest generation (G4) assay has a reduced risk of false positive results for rifampicin resistance [8].The probe B sequence was modified so that the probe/wild-type target hybrid remains stable at elevated annealing temperatures, further improving specificity to 99.8% under research conditions [8].
The use of filtration techniques for the lysis and study of red blood cells
Authors: Donald E. Hultquist, Michael R. Vasko, Robert H. Gray
Journal: American Journal of Hematology (1977)

Abstract A filtration technique for the gentle lysis of erythrocytes has been developed using cellulose triacetate membranes. When cell suspensions are filtered under nitrogen pressure, lysis occurs at the surface of the filter in such a way that the cell ghosts are retained on the filter. The contents of the cell are extruded through the pores of the filter without mixing with the cell suspension. Cell ghosts and intact erythrocytes have been collected on membranes and examined by electron microscopy. These preparations have the advantage of being free of the structural artifacts that result from centrifugation. In addition, the filter facilitates preparation for electron microscopy by providing a support for the sample during fixation and then dissolving during the dehydration of the sample.
Dr. Chambers on Mercury in Phthisis
Authors: R. Chambers
Journal: BMJ (1840)

to whicih the vein is obliterated or contracted below the eschar is seldom great, the good effects of the operation being generally not experienced beyond three or four inches below the eschar, or not beyond the point where considerable anastomotic branches exist.From ignoranice of this fact in some of our earlier cases, the success was not complete, the caustic having, been applied too high upon the truink of the saphlena, under the idea that all the branclhes below would be obliterated by deposits of fibrine.Subsequently, the success of the treatment was greater, from the caustic having been applied upon varicose branches not more thani two or three inches above the ulcer, care being taken that no large aniastomotic branch intervene between the eschar and the ulcer.This plan of treatment, however, has not been altogetlier uniattended with inconveniences.In three of the earlier cases, haemorrhage occurred, from the patients being allowed to resume the erect posture, and to take exercise soon after the separation of the eschar.This accidenit lha, however, since been effectually prevented, by insisting upon the recumbent posture being preserved until the sore pro- duced by the caustic has advanced ccnsiderably in the pro-
Abstract 4517: Syndecan-2 methylation is an early detection biomarker for colorectal cancer with high sensitivity and specificity in small serum sample volumes
Authors: Benjmain D. Hoehn, TaeJeong Oh, Na Y. Kim, Young H. Moon, Nam K. Kim, Tae S. Kim, Sang S. Shin, Seung H. Lee, Ik-Soon Jang, Sungwhan An, Hyun C. Chung
Journal: Cancer Research (2012)

Abstract BACKGROUND: Colorectal cancer (CRC) is a major cause of morbidity and mortality in the world. Epigenetics has been a useful tool in the development of sensitive and specific screening tests for CRC. Targeting genes highly methylated in CRC has allowed us to develop an accurate method to select novel candidate genes and validate their sensitivity and selectivity through testing in clinical samples. METHODS: We performed CpG microarray analysis using methylation enriched DNA from tumors and matched normal appearing tissues to identify genes methylated in CRC. We then applied a step-wise filtering method to narrow our field of candidate genes. Six genes were verified for high methylation-positivity in CRC cell lines and underwent negative selection in healthy normal samples using bisulfate-pyrosequencing. Genes SORCS3, SIM1, SDC2 were selected for low levels of methylation in normal tissue followed by verification with MSP-pyrosequencing. RESULTS: SDC2 was then selected because of high methylation levels in tumor and very low levels in normal tissue. SDC2 methylation levels were measured in 133 tumors and were found to be significantly methylated at all stages. Next, 500αl sera samples from 42 CRC patients were tested using qMSP which demonstrated sensitivity at 71.4% and specificity 92.9%. CONCLUSIONS: This study utilized refined technologies to identify and validate a novel candidate SCD2 for CRC screening in serum with high sensitivity and selectivity using only 500αl. These findings demonstrate a new level of candidate selection, verification and application that we feel will meet the need for a new minimally-invasive screening test. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4517. doi:1538-7445.AM2012-4517