tbuckley/cabot-search huggingface dataset:
999-118 Distributing a Cardiology Database on an Enterprise Network: Changing Paradigms in Information Systems
Authors: William S. Weintraub, Fara Hicks, Debbie Canup, Peter Little, J. Larry Klein, Ryan Gill, Candice Saunders, Douglas A. Morris, R. Wayne Alexander, Spencer B. King, Robert A. Guyton
Journal: Journal of the American College of Cardiology (1995)
Maximal Rates of Excretion and Synthesis of Urea in Normal and Cirrhotic Subjects
Authors: Daniel Rudman, Thomas J. DiFulco, John T. Galambos, Robert B. Smith, Atef A. Salam, W. Dean Warren
Journal: Journal of Clinical Investigation (1973)

When normal individuals eat 0.33 g protein N/kg body weight (BW)((3/4)) per day, they excrete 10-15 mg urea N/h per kg BW((3/4)). If they now ingest (at 0 h) 0.27 (dose A), 0.40 (dose B), 0.53 (dose C), 0.94 (dose D), or 1.33 (dose E) g protein N/kg BW((3/4)) (in the form of casein, ovalbumin, or lactalbumin), the rate of urea N excretion accelerates within 4 h. At dose C a maximal rate of urinary urea N excretion (MRUE) is reached, which averages 55 mg urea N/h per kg BW((3/4)) and which persists for 16 h. Higher doses of protein do not further accelerate urea excretion, but prolong the duration of MRUE to 28 h (after dose E). Blood urea N (BUN) rises by 7-20 mg/100 ml during the first 8 h after dose C to E, and remains stable within +/-5 mg/100 ml during the ensuing 8-28 h of MRUE. Each increment of protein above dose C causes a further increment in plasma alpha-amino N. During infusion of free amino acids at a rate of 110 or 165 mg amino acid N/h per kg BW((3/4)) for 12 h, rate of urea excretion increases to the MRUE value produced by dose C-E of oral protein.These findings indicate that MRUE corresponds to a period of maximal rate of urea synthesis (MRUS). MRUS is greater than MRUE because one fraction of newly formed urea is hydrolyzed in the gastrointestinal tract, and another fraction may accumulate temporarily in body water during the MRUE period. Oral neomycin reduces the proportion of urea hydrolyzed in the gut to less than 20%; its extent is measured by recovery in the urine of a tracer dose of [(14)C]urea injected intramuscularly during determination of MRUE. Accumulation of urea in body water is estimated from increment in BUN during the period of MRUE measurement (8-24 h after dose E of casein) and from body water measured with (3)H(2)O. Then MRUS is calculated as: ([mg urea N excreted between 8 and 24 h after dose E] + [BUN at 24 h - BUN at 8 h] x [body water]) x (100/% recovery [(14)C]urea) x (1/kg BW((3/4))) x (1/16 h).MRUS in 10 normal subjects averaged 65 mg urea N/h per kg BW((3/4)) (range 55-76), and in 34 cirrhotics 27 mg urea N/h per kg BW((3/4)) (range 6-64). Among 19 cirrhotic patients fed 40, 60, 80, or 100 g protein daily for successive 10 day periods, the occurrences of hyperammonemia, hyperaminoacidemia, and encephalopathy at each level of protein intake were inversely related to MRUS value.
ENDOMETRIOMATA: THE FIVE CLINICAL TYPES
Authors: V. B. Green-Armytage, S. K. Datta
Journal: BMJ (1933)

HMEDICAL TURNAL subsided.Sputum negative for tubercle bacilli.Dry cough, and had failure to gain weight between these attacks.Signs .Undernourished, and dullness, with weak breath sounds and crepitations at right base, and weak breath sounds and crepitations at left base.Radiograph: Tubular bronchiectasis of the right lower bronchi (Fig. 4).Resuilt : Bronchitis rapidly
CIGARETTE SMOKING AND THE PHYSICIAN
Authors: DAVID J. CROSBY
Journal: Annals of Internal Medicine (1968)

Letters and Comments1 October 1968CIGARETTE SMOKING AND THE PHYSICIANDAVID J. CROSBY, M.D.DAVID J. CROSBY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-69-4-845_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: I truly enjoyed the editorial on smoking by Edward J. Huth, M.D. (Ann. Intern. Med. 69: 163, 1968). His attitude toward smoking is deliciously analogous to that of Carry Amelia Nation towards alcohol. I'm only surprised that he has not recommended "hatchetization" of cigarette machines! Incidentally, Carry also spoke against tobacco, foreign foods, corsets, skirts of improper length, and paintings of the sort found in barrooms.Dr. Huth has shown remarkable restraint, but nonetheless I'm afraid that his evangelical attempts to change national patterns of behavior will produce about the same response as that evoked by Carry... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Internal Medicine Tucson Hospitals Medical Education Program Tucson, Ariz. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1968Volume 69, Issue 4Page: 845-845KeywordsAlcoholsBehaviorFood Issue Published: 1 October 1968 PDF downloadLoading ...
1085-166 Does hormone replacement therapy in women influence their benefit of losartan-treatment in the LIFE study?
Authors: Kristian Wachtell, Richard B Devereux, Steven M Snapinn, Michael H Olsen, Ulf de Faire, Hans Ibsen, Stevo Julius, Sverre E Kjeldsen, Lars H Lindholm, Markku S Nieminen, Björn Dahlöf
Journal: Journal of the American College of Cardiology (2004)
Heart Disease in Massachusetts in Relation to the Workmen's Compensation Act
Authors: Richard J. Clark, Emma Sanborn Tousant, Howard B. Sprague
Journal: New England Journal of Medicine (1955)

IN the State of Massachusetts and, indeed, in many other states, there is an important medical-social-economic problem that is unfamiliar to a large portion of the medical profession. We refer to the Workmen's Compensation Act, especially as it concerns the cardiac patient but also as it affects other persons with chronic disease and disability. This problem is of importance to physicians since their patients may be involved with compensation disputes, since they may be called on to testify before the Industrial Accident Board or courts and, most important, because as a profession they should be concerned with rehabilitation of patients . . .
Defining the molecular profile of planarian pluripotent stem cells using a combinatorial RNA-seq, RNA interference and irradiation approach
Authors: Jordi Solana, Damian Kao, Yuliana Mihaylova, Farah Jaber-Hijazi, Sunir Malla, Ray Wilson, Aziz Aboobaker
Journal: Genome biology (2012)

Abstract Background Planarian stem cells, or neoblasts, drive the almost unlimited regeneration capacities of freshwater planarians. Neoblasts are traditionally described by their morphological features and by the fact that they are the only proliferative cell type in asexual planarians. Therefore, they can be specifically eliminated by irradiation. Irradiation, however, is likely to induce transcriptome-wide changes in gene expression that are not associated with neoblast ablation. This has affected the accurate description of their specific transcriptomic profile. Results We introduce the use of Smed-histone-2B RNA interference (RNAi) for genetic ablation of neoblast cells in Schmidtea mediterranea as an alternative to irradiation. We characterize the rapid, neoblast-specific phenotype induced by Smed-histone-2B RNAi, resulting in neoblast ablation. We compare and triangulate RNA-seq data after using both irradiation and Smed-histone-2B RNAi over a time course as means of neoblast ablation. Our analyses show that Smed-histone-2B RNAi eliminates neoblast gene expression with high specificity and discrimination from gene expression in other cellular compartments. We compile a high confidence list of genes downregulated by both irradiation and Smed-histone-2B RNAi and validate their expression in neoblast cells. Lastly, we analyze the overall expression profile of neoblast cells. Conclusions Our list of neoblast genes parallels their morphological features and is highly enriched for nuclear components, chromatin remodeling factors, RNA splicing factors, RNA granule components and the machinery of cell division. Our data reveal that the regulation of planarian stem cells relies on posttranscriptional regulatory mechanisms and suggest that planarians are an ideal model for this understudied aspect of stem cell biology.
Piloting when you 'should' be sleeping: what effects?
Authors: Phil Gunby
Journal: JAMA (1981)

Researchers call it "circadian desynchronosis," the public calls it "jet lag," and the National Aeronautics and Space Administration (NASA) calls it a potential health hazard for anyone aboard an airliner flown by a pilot who probably should be sleeping. To "determine how irregular work schedules, disrupted sleep patterns, and frequent crossing of time zones affect airline pilot performance," NASA's Ames Research Center near San Francisco is conducting a four-part study. As a first step, the scientific literature on circadian physiology is being reviewed. This information will be summarized in nontechnical terms for the aviation community. Second, a study of rest, diet, and medication use patterns of commercial airline crews will be undertaken. Third, Ames' facility for prolonged bed rest (to simulate astronauts' weightlessness) will be used to study altered sleep and nutrition patterns. Fourth, facilities under construction (including simulated airplane cockpits) will allow volunteer airline crews to "fly" for several
To Mend the Heart: The Dramatic Story of Cardiac Surgery and Its Pioneers
Authors: Alan T. Marty
Journal: JAMA (1980)

Nearly every surgeon who has surgically entered a living human heart is still alive. This book salutes these pioneers whose "competence, courage and physiques have transformed brave but disappointing adventures into consistent service to suffering children, women, and men." It is a story of people "unimpressed by arbitrary limitations imposed by conventional thinking." In lauding these heroes, it carefully differentiates "noble pioneering efforts" from "simple risk taking." The "generalissimo and pivotal personality" is Dwight Harken, who is correctly depicted as the man who, more than any other, "moved heart surgery up a decade. A person with less flamboyance, less ego, less drive, less confidence—and less freedom—couldn't have done it." Concurrently, almost all of the other cardiac surgical giants are given their due. The many anecdotes, taken largely from oral histories, prove "embarrassing to some, interesting to more, and edifying to many." Samuel Levine, for example, is quoted about an incident
NON-ATHEROSCLEROTIC SPONTANEOUS CORONARY ARTERY DISSECTION ASSOCIATION WITH PREDISPOSING AND PRECIPITATING CONDITIONS AND CARDIOVASCULAR OUTCOMES
Authors: Jacqueline W.L. Saw, Eve Aymong, Christopher Buller, Tara Sedlak, Andrew Staravoytov, Donald Ricci, Karin Humphries, John Mancini
Journal: Journal of the American College of Cardiology (2014)
Heart transplant pioneer cleared
Authors: C. Dyer
Journal: BMJ (1997)

The team headed by the heart transplant pioneer Sir Magdi Yacoub was cleared of negligence in the High Court last week for failing to warn of the risk that a heart transplant operation could leave a child severely brain damaged.

Kevin and Linda Poynter sued Hillingdon health authority in West London, claiming they would not have allowed their son, Matthew, now 10, to undergo the operation at Harefield Hospital had they known of the risk. They told the court they were opposed to transplantation in …
Nurse Practitioner Practice Patterns Based on Standards of Medical Care for Patients With Diabetes
Authors: James A Fain, Gail D'Eramo Melkus
Journal: Diabetes Care (1994)

OBJECTIVE To determine to what extent nurse practitioner (NP) practice patterns of diabetes care are consistent with standards of care suggested by the American Diabetes Association (ADA). RESEARCH DESIGN AND METHODS A descriptive study was conducted to examine practice patterns. A convenience sample of 78 charts was audited, representing a proportionate number of charts for each of the six masters-prepared, certified NPs employed in an ambulatory primary-care center. RESULTS Practice patterns related to diabetes care revealed a discrepancy between established standards of care and the degree to which care was documented. All six NPs acknowledged that they became clinically competent to care for patients with diabeteson the job. CONCLUSIONS Results of this small study suggest that NPs are not consistently following standards of care suggested by the ADA.
Abstract 2049: A novel, potent, Cyp17 inhibitor with favorable pharmacokinetics and oral bioavailability for potential treatment of human castration resistant prostate cancer (CRPC).
Authors: Ying Feng, Bing Wang, Daniel Chu, Leonard Post, Yuqiao Shen
Journal: Cancer Research (2013)

Abstract Cytochrome P450 17α-hydroxylase/C17,20-lyase (CYP17) is a key enzyme in androgen bio-synthesis in adrenals and testes. It has been validated clinically as an effective target for CRPC through successful clinical trials with abiraterone acetate. Abiraterone acetate is a selective, potent inhibitor of Cyp17, and was recently approved as a treatment for CRPC. We have designed a novel Cyp17 inhibitor, BMN680, with improved pharmacokinetic (PK) profile and oral bioavailability while maintaining potent Cyp17 inhibition. BMN680 inhibits Cyp17 lyase activity with IC50 of 0.8 nM and reduces testosterone production in human adrenal cancer cell line H295R cells with IC50 of 3.87 nM. in vitro metabolic stability studies indicate that BMN680 has a half-life of 5-hr in human liver microsome and 8-hr half-life in human hepatocytes. Animal PK profiling in rats and monkeys demonstrated BMN680 has in vivo half-life of &amp;gt;4 hr and oral bioavailability of &amp;gt;30%. Single oral dosing of BMN680 at 10 mg/kg in normal, intact, Cynomolgus monkeys resulted in suppression of plasma testosterone level for up to 24 hour. Pharmacodynamic (PD) effect of single and multi-day oral dosing of BMN680 in monkey will be presented. In human liver microsome Cyp panel screen, BMN680 exhibited IC50 greater than 1.5 uM for all Cyp enzymes tested including 1A2, 2C9, 2C19, 2D6, 3A4, indicating low potential of drug-drug interaction. In conclusion, BMN680 is a potent Cyp17 inhibitor with low interaction with Cyp450 isoforms, and desirable PK and oral bioavailability. BMN680 can effectively suppress testosterone production in vivo, and will be further evaluated in preclinical development. Citation Format: Ying Feng, Bing Wang, Daniel Chu, Leonard Post, Yuqiao Shen. A novel, potent, Cyp17 inhibitor with favorable pharmacokinetics and oral bioavailability for potential treatment of human castration resistant prostate cancer (CRPC). [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2049. doi:10.1158/1538-7445.AM2013-2049
Extraosseous Myxoid Chondrosarcoma With Pulmonary and Nodal Metastases on FDG PET-CT
Authors: Linh Ho, Howard Youngworth, Robert Henderson, John Seto
Journal: Clinical Nuclear Medicine (2008)

We report the PET-CT appearance of extraosseous myxoid chondrosarcoma in the left gluteus maximus muscle with diffuse pulmonary and nodal metastases in a 65-year-old man who presented with a large left gluteal mass. Pretherapeutic tumor SUV obtained by FDG PET imaging has been reported as a useful parameter for tumor grading and prediction of outcome in chondrosarcoma patients. In addition, the combination of SUV and histopathologic tumor grade further improves prediction of outcome substantially, allowing identification of patients at high risk for local relapse or metastatic disease.
Lack of inotropic effect of cyclosporin A in isolated guinea pig left atria
Authors: S.-J. Hu, G. Inselmann, K. Mohr, U. Nellessen
Journal: Cardiovascular Research (1993)

Cyclosporin A is being widely used to prevent graft rejection in organ transplantation and to treat autoimmune diseases. Since various toxic side effects have been observed, the aim of this study was to look for even a subtle deleterious effect of cyclosporin A on cardiac inotropy in electrically stimulated guinea pig left atria.The left atrial muscles of guinea pigs, in Tyrode's solution containing 2.7 or 5.4 mM potassium, were electrically stimulated by one of two methods: (1) continuously at 3 Hz, during which cyclosporin A was applied cumulatively (from 10(-9) to 10(-5) M); or (2) stimulated intermittently at 2.5 Hz in 5 mM cyclosporin A, with rest periods of 4 s duration interposed every 4 min. The effects of cyclosporin A on contractile force were observed for 150 min in the first stimulation method, and the effects on the steady state contractile force and amplitude of post-rest contraction were observed for 240 min in the second method.The steady state contractile force of the atria declined within the 4 h period at 2.7 mM potassium in Tyrode's solution both in the cyclosporin A group (n = 10) and in the control group (n = 5) to 68(SD 11)% and to 63(4)%, respectively. After 4 h the amplitudes of the post-rest contraction were 101(16)% and 101(4)% in cyclosporin A and control groups, respectively. At 5.4 mM potassium, the following values were obtained (cyclosporin A v control): steady state force 70(8)% (n = 11) v 69(8)% (n = 5); post-rest force 105(9)% v 102(7)%.Cyclosporin A does not influence the steady state contractile force or the amplitude of the post-rest contraction, suggesting the absence of inotropic effects on isolated guinea pig left atria.
HEART RATE VARIABILITY AND MARKERS OF SUBCLINICAL CARDIOVASCULAR DISEASE. THE CORONARY ARTERY RISK DEVELOPMENT IN YOUNG ADULTS STUDY
Authors: Khalil Murad, Donald M. Lloyd-Jones, Elsayed Z. Soliman, Mercedes Carnethon, Richard Sloan, Hongyan Ning, Sharina D. Person, David C. Goff
Journal: Journal of the American College of Cardiology (2011)
Managed Care Medicine: The Official Journal of the National Association of Managed Care Physicians
Authors: Steven D. Taylor
Journal: JAMA (1996)

Most physicians have accepted the fact that they cannot escape the business side of medicine. This acceptance comes from confronting decisions about health maintenance organization contracts, capitation, formularies, and the like. Unfortunately,<i>Managed Care Medicine</i>is not the best journal to help physicians with making these decisions. <i>Managed Care Medicine</i>has an impressive visual appearance. Physician representatives from many of the nation's largest pharmaceutical companies and health care networks serve on the editorial board. Yet, the quality of writing and editing could be improved. A 1994 article on antidepressants, for example, contains several wordy passages. References in this article date from 1988 through 1990. The authors cite two popular magazines but fail to include clinical research articles on antidepressants. None of the articles is preceded by an abstract. In several instances advertisements interrupt the text. On the other hand, the editor has targeted an audience of "high-prescribing, office-based physicians." The
The Effects of Repeated Thermal Therapy for Patients with Chronic Pain
Authors: Akinori Masuda, Yasuyuki Koga, Masato Hattanmaru, Shinichi Minagoe, Chuwa Tei
Journal: Psychotherapy and Psychosomatics (2005)

It has been reported that local thermal therapy with a hot pack or paraffin relieves pain. We hypothesized that systemic warming may decrease pain and improve the outcomes in patients with chronic pain. The purpose of this study was to clarify the effects of systemic thermal therapy in patients with chronic pain.Group A (n = 24) patients with chronic pain were treated by a multidisciplinary treatment including cognitive behavioral therapy, rehabilitation, and exercise therapy, whereas group B (n = 22) patients were treated by a combination of multidisciplinary treatment and repeated thermal therapy. A far-infrared ray dry sauna therapy and post-sauna warming were performed once a day for 4 weeks during hospitalization. We investigated the improvements in subjective symptoms, the number of pain behavior after treatment and outcomes 2 years after discharge.The visual analog pain score, number of pain behavior, self-rating depression scale, and anger score significantly decreased after treatment in both groups. After treatment, the number of pain behavior was slightly smaller (p = 0.07) and anger score was significantly lower in group B than those in group A (p = 0.05). Two years after treatment, 17 patients (77%) in group B returned to work compared with 12 patients (50%) in group A (p < 0.05).These results suggest that a combination of multidisciplinary treatment and repeated thermal therapy may be a promising method for treatment of chronic pain.
Assessing the Sensitivity of Different Life Stages for Sexual Disruption in Roach ( <i>Rutilus rutilus</i> ) Exposed to Effluents from Wastewater Treatment Works
Authors: Katherine E. Liney, Susan Jobling, Jan A. Shears, Peter Simpson, Charles R. Tyler
Journal: Environmental Health Perspectives (2005)

Surveys of U.K. rivers have shown a high incidence of sexual disruption in populations of wild roach (Rutilus rutilus) living downstream from wastewater treatment works (WwTW), and the degree of intersex (gonads containing both male and female structural characteristics) has been correlated with the concentration of effluent in those rivers. In this study, we investigated feminized responses to two estrogenic WwTWs in roach exposed for periods during life stages of germ cell division (early life and the postspawning period). Roach were exposed as embryos from fertilization up to 300 days posthatch (dph; to include the period of gonadal sex differentiation) or as postspawning adult males, and including fish that had received previous estrogen exposure, for either 60 or 120 days when the annual event of germ cell proliferation occurs. Both effluents induced vitellogenin synthesis in both life stages studied, and the magnitude of the vitellogenic responses paralleled the effluent content of steroid estrogens. Feminization of the reproductive ducts occurred in male fish in a concentration-dependent manner when the exposure occurred during early life, but we found no effects on the reproductive ducts in adult males. Depuration studies (maintenance of fish in clean water after exposure to WwTW effluent) confirmed that the feminization of the reproductive duct was permanent. We found no evidence of ovotestis development in fish that had no previous estrogen exposure for any of the treatments. In wild adult roach that had previously received exposure to estrogen and were intersex, the degree of intersex increased during the study period, but this was not related to the immediate effluent exposure, suggesting a previously determined programming of ovotestis formation.
LOCALIZATION OF LEFT ANTERIOR CORONARY ARTERY DISEASE WITH EXERCISE EQUILIBRIUM RADIONUCLIDE VENTRICULOGAPHY
Authors: Asher Kimchi, Daniel Berman, Alan Rozanski, Caryl Fletcher, Jamshid Maddahi, Steven Reisman, Franklin Murphy, H. J.C. Swan
Journal: Clinical Nuclear Medicine (1982)

Kimchi, Asher; Berman, Daniel; Rozanski, Alan; Fletcher, Caryl; Maddahi, Jamshid; Reisman, Steven; Murphy, Franklin; Swan, H. J.C. Author Information
Towards Safer Cardiac Surgery
Authors: John M. Moran
Journal: JAMA (1982)

<b>Perioperative Management in Cardiothoracic Surgery,</b>by Benson B. Roe, 273 pp, with illus, $25, Boston, Little Brown &amp; Co, 1981. <i>Towards Safer Cardiac Surgery</i>is based on the proceedings of an international symposium at the University of York, England, in April 1980. The theme of the symposium, and hence the book, is well reflected in the title. Not all chapters reflect this approach, but the majority do. These published proceedings are international, but only in the sense that a few scattered chapters are from outside the United Kingdom. The diversity of this book is indicated by the fact that there are 59 contributors from 17 disciplines, the latter ranging from surgery to radiological biochemistry, microbiology, and psychiatry. At first, the multiple authorship tends to put one off until it is realized that the variations in style, organization, and content are a positive influence. There are Julian's homilies on the importance