Sulindac Causing a Hypersensitivity Reaction with Peripheral and Mediastinal Lymphadenopathy
Authors: DOUGLAS JAY SPRUNG
Journal: Annals of Internal Medicine (1982)

Brief Reports1 October 1982Sulindac Causing a Hypersensitivity Reaction with Peripheral and Mediastinal LymphadenopathyDOUGLAS JAY SPRUNG, M.D.DOUGLAS JAY SPRUNG, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-97-4-564 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSulindac, one of the newer nonsteroidal anti-inflammatory agents, has gained popularity because it can be taken twice a day and has few adverse effects. Reactions to sulindac include hepatotoxicity (1), bone marrow aplasia (2), acute febrile hypersensitivity reactions (3, 4), and Stevens-Johnson syndrome (5). More common side effects include nausea, vomiting, rashes, and headaches. This report describes a febrile hypersensitivity reaction with concomitant splenomegaly and mediastinal as well as general peripheral lymphadenopathy.A 61-year-old white man presented with a 10-day history of headache, fever, rash, malaise, and lymphadenopathy. This condition had occurred 1 year earlier, lasting 6 weeks, with complete...References1. ANDERSON R. Severe reaction associated with sulindac administration. N Engl J Med. 1979;300:735-6. CrossrefMedlineGoogle Scholar2. MILLER J. Marrow aplasia and sulindac [Letter]. Ann Intern Med. 1980;92:129. LinkGoogle Scholar3. RUSSELL I. Reaction to sulindac [Letter]. Ann Intern Med. 1980;92:176. LinkGoogle Scholar4. SMITHLINDBERG FP. Life threatening hypersensitivity to sulindac. JAMA. 1980;244:269-70. CrossrefMedlineGoogle Scholar5. LEVITTPEARSON LR. Sulindac-induced Stevens-Johnson toxic epidermal necrolysis syndrome. JAMA. 1980;243:1262-3. CrossrefMedlineGoogle Scholar6. LEVITESHAFITZKIRUBAKARAN RGM. Febrile reaction to sulinadac [Letter]. JAMA. 1981;246:213-4. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Durham, North Carolina PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByFine Art in Dark Corners: Goals and Realities of International Cultural Property ProtectionPulmonary Infiltrates Associated with Sulindac TherapyChanges in body temperature after administration of antipyretics, LSD, Δ9-THC and related agents: IIIncidence of serious side-effects from non-steroidal anti-inflammatory drugs (NSAIDs) in the USARare adverse reactions to non-steroidal anti-inflammatory drugsClinical pharmacology of non-steroidal anti-inflammatory drugsAdverse reactions to nonsteroidal anti-inflammatory drugs diclofenac compared with other nonsteroidal anti-inflammatory drugsAntiinflammatory and Immunosuppressive Drugs in the Treatment of Rheumatoid ArthritisSulindac Hepatotoxicity: A Case Report and ReviewAntiinflammatory analgesics and durgs used in rheumatoid arthritis and gout 1 October 1982Volume 97, Issue 4Page: 564-565KeywordsBone marrowFeversHypersensitivityNSAIDsNauseaRashesSplenomegalyVomiting Issue Published: 1 October 1982 PDF DownloadLoading ...