tbuckley/cabot-search huggingface dataset:
Predictors of ovarian response: progress towards individualized treatment in ovulation induction and ovarian stimulation
Authors: B.C.J.M. Fauser, K. Diedrich, P. Devroey
Journal: Human Reproduction Update (2007)

Ovarian stimulation is applied in the clinic to restore mono-ovulatory cycles in anovulatory women (ovulation induction) or to induce the development of multiple dominant follicles for assisted reproduction. Ovarian response is the endocrine and follicular reaction of the ovaries to stimulation. Achieving an appropriate ovarian response to anti-estrogens or exogenous gonadotrophins is central to ovulation induction and ovarian stimulation protocols. However, achieving an adequate response, without cycle cancellation or adverse events related to under- or over-stimulation, is complicated by high intra- and inter-individual variability. To predict each patient's ovarian response to medication for ovarian stimulation and to individualize the starting dose of exogenous gonadotrophin or the need for exogenous luteinizing hormone, various clinical, endocrine, ovarian ultrasonographic and genetic characteristics have been explored. Some of these features have been incorporated into prediction models. In this review, the methodology behind predictive factors and prediction models and their potential clinical applicability across ovulation induction and ovarian stimulation are explored.
Overexpression of survivin in primary ATL cells and sodium arsenite induces apoptosis by down-regulating survivin expression in ATL cell lines
Authors: Xiao-Fang Che, Chun-Lei Zheng, Satsuki Owatari, Masato Mutoh, Takenari Gotanda, Hei-Cheul Jeung, Tatsuhiko Furukawa, Ryuji Ikeda, Masatatsu Yamamoto, Misako Haraguchi, Naomichi Arima, Shin-ichi Akiyama
Journal: Blood (2006)
Circulation of the Giraffe
Authors: ROBERT H. GOETZ, JAMES V. WARREN, OTTO H. GAUER, JOHN L. PATTERSON, JOSEPH T. DOYLE, E. N. KEEN, MAURICE McGREGOR, L. M. TILLER, M. SMITH, E. Mance
Journal: Circulation Research (1960)

Observations on the circulatory functions of 4 giraffes are recorded. Both the right and the left heart were catheterized under local anesthesia with a miniature manometer. Cardiac output was determined by employing both indicator dilution method and the Fick principle. Other parameters, such as the circulation time, blood volume, velocity, right and left ventricular pressure ascent as well as the changes in blood pressure occurring with changes in the Posture of the head were recorded. The difficulties of the experiments created certain limitations in their interpretation. The arterial blood pressure is high by human standards and adequate to maintain cerebral perfusion without other means of support. The arterial pressure pulse contour suggests a relatively lax vascular bed with considerable reserve distensibility. Values for cardiac output and blood volume were roughly comparable to those recorded in domestic cattle of the same approximate weight.
Characterization of CD45−/CD31+/CD105+ Circulating Cells in the Peripheral Blood of Patients with Gynecologic Malignancies
Authors: Hyun-Kyung Yu, Ho-Jeong Lee, Ha-Na Choi, Jin-Hyung Ahn, Ji-Young Choi, Haeng-Seok Song, Ki-Heon Lee, Yeup Yoon, Lee S. H. Yi, Jang-Seong Kim, Sun Jin Kim, Tae Jin Kim
Journal: Clinical Cancer Research (2013)

Circulating endothelial cells (CEC) have been widely used as a prognostic biomarker and regarded as a promising strategy for monitoring the response to treatment in several cancers. However, the presence and biologic roles of CECs have remained controversial for decades because technical standards for the identification and quantification of CECs have not been established. Here, we hypothesized that CECs detected by flow cytometry might be monocytes rather than endothelial cells.The frequency of representative CEC subsets (i.e., CD45(-)/CD31(+), CD45(-)/CD31(+)/CD146(+), CD45(-)/CD31(+)/CD105(+)) was analyzed in the peripheral blood of patients with gynecologic cancer (n = 56) and healthy volunteers (n = 44). CD45(-)/CD31(+) cells, which are components of CECs, were isolated and the expression of various markers (CD146, CD105, vWF, and CD144 for endothelial cells; CD68 and CD14 for monocytes) was examined by immunocytochemistry.CD45(-)/CD31(+)/CD105(+) cells were significantly increased in the peripheral blood of patients with cancer, whereas evaluation of CD45(-)/CD31(+)/CD146(+) cells was not possible both in patients with cancer and healthy controls due to the limited resolution of the flow cytometry. Immunocytochemistry analyses showed that these CD45(-)/CD31(+)/CD105(+) cells did not express vWF and CD146 but rather CD144. Furthermore, CD45(-)/CD31(+)/CD105(+) cells uniformly expressed the monocyte-specific markers CD14 and CD68. These results suggest that CD45(-)/CD31(+)/CD105(+) cells carry the characteristics of monocytes rather than endothelial cells.Our data indicate that CD45(-)/CD31(+)/CD105(+) circulating cells, which are significantly increased in the peripheral blood of patients with gynecologic cancer, are monocytes rather than endothelial cells. Further investigation is required to determine the biologic significance of their presence and function in relation with angiogenesis.
Metallic stent for airway complications after lung transplantation long term follow up
Authors: Nader Abdel-rahman, Oren Fruchter, Mordechai R. Kramer
Journal: European Respiratory Journal (2013)

Background: Bronchial stenosis after Lung transplantation( causes are listed in Table 1) is the most common airway complication and mostly seen at the Surgical anastomosis, Although the improvement in surgical techniques and increasing experience has significantly reduced the incidence of such complications,stenosis pose a major therapeutic challenge, Flexible fibrooptic bronchoscopy(FFB) is the gold standard for diagnosis, Stent placement may treat this complication with varying success we investigated the role Self expandable Metal Stents (SEMS) in the treatment of airway stenosis after transplantation.

View this table:

Transplantation etiology





Objectives :Investigate the influence of SEMS insertion on the survival, mortality, the need for second SEMS,

Methods: Data was collected from the database pool of our institution, retrospectively analyzes of the medical records of lung transplanted patients that suffered from Stenosis at the anastomoises areas and underwent self expandable metallic stent insertion

Results: One, three, and five years survival in patients that required SEMS 77.7%, 66.6% and 55.5% respectively. The corresponding survival rates in patients without stents were 69%, 64.9% and 61.1%.

Conclusions: SEMS are safe and effective tool in the management of airway complications post-LTX an immediate improvement in symptoms and flows in the majority of cases. long term mortality is slightly higher in patients with stents compared with LTX patients without.
Physiotherapeutic management of lumbar spine pathology
Authors: M Cusi
Journal: British Journal of Sports Medicine (2007)

Edited by David McDonald, Rick Jemmett. Halifax, NS, Canada: Novont Health Publishing, 2005, £69.72, US$131.35 (approx), €102.23 (approx), pp 196 (softcover). ISBN 0968871526

Asking a sports physician why he would review a book on physiotherapeutic management of low back pain is akin to asking a mountaineer why he climbed Mt Everest: because it is there! On a more serious note, an interest in the lumbopelvic region included me in the targeted audience (“Clinicians in the orthopaedic conservative-care community”), and I did find the book an interesting read.

It aimed to present a clinical model for the approach to a specific subset of patients with low back pain. This was done …
Abnormal Ca2+ release from cardiac sarcoplasmic reticulum in tachycardia-induced heart failure
Authors: T Yamamoto
Journal: Cardiovascular Research (1999)

Objective: In heart failure, little information is available as to the Ca2+ release function of sarcoplasmic reticulum (SR), which plays a major role in cardiac contractile function. Here, we assessed the rapid kinetics of drug-induced Ca2+ release from cardiac SR in combination with a measurement of ryanodine binding in heart failure. Methods: The SR vesicles were isolated from dog left ventricular (LV) muscles (normal (N), n=10; pacing induced heart failure (HF), n=10). The time course of SR Ca2+ release was continuously monitored by a stopped-flow apparatus using arsenazoIII as a Ca2+ indicator, and Ca2+ uptake and [3H]ryanodine binding assays were done using a filtration method. Results: The amount of Ca2+ uptake was reduced in HF to 55% of N (P<0.05). Even the more marked and earlier appeared decrease was seen in the rate constant and the initial rate of polylysine (PL; a specific release trigger)-induced Ca2+ release (P<0.05). However, the PL concentration dependency of the initial rate shifted towards lower concentrations of PL in HF than in N ([PL] at half maximum stimulation=0.13 vs. 0.35 μM). The [3H]ryanodine binding assay revealed a lower Bmax (pmol/mg) in HF than in N (0.91±0.19 vs. 2.64±0.59, P<0.05), but no difference in Kd (nM) (0.95±0.29 vs. 0.90±0.11, P=n.s.). The [PL] dependency on the enhancement of [3H]ryanodine binding again showed a shift towards lower [PL] in HF than in N. Conclusions: In pacing-induced heart failure, the Ca2+ releasing function of SR is disturbed, which may result in an intra-cellular Ca2+ transient that was slowed down.
Effects of Prolactin on <i>TSC2</i>-Null Eker Rat Cells and in Pulmonary Lymphangioleiomyomatosis
Authors: Yasuhiro Terasaki, Kinnosuke Yahiro, Gustavo Pacheco-Rodriguez, Wendy K. Steagall, Mario P. Stylianou, Jilly F. Evans, Ameae M. Walker, Joel Moss
Journal: American Journal of Respiratory and Critical Care Medicine (2010)

Rationale: Lymphangioleiomyomatosis, a cystic lung disease of women, is characterized by proliferation of smooth muscle–like lymphangioleiomyomatosis cells, which possess mutations in the tuberous sclerosis complex genes, TSC1/TSC2. Growth factors involved in lymphangioleiomyomatosis cell proliferation are unknown. Prolactin, an important reproductive hormone in women, is known to promote cell proliferation and survival in other tissues.Objectives: To determine the role of prolactin in signaling and proliferation in lymphangioleiomyomatosis.Methods: Prolactin levels in the sera of patients with lymphangioleiomyomatosis were correlated with clinical status. Components of prolactin signal transduction pathways were assessed in lymphangioleiomyomatosis lesions from human lung explants by real-time reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry. Prolactin effects on proliferation and signaling were quantified in tuberin-deficient and tuberin-expressing rat cells in vitro.Measurements and Main Results: Higher prolactin levels in the sera of patients with lymphangioleiomyomatosis were associated with a faster rate of decline in FEV1 and an increased history of pneumothorax (P < 0.01). Higher levels of prolactin and prolactin receptor mRNA and immunoreactivity were found in lymphangioleiomyomatosis lesions when compared with vascular smooth muscle cells in the same region of tissue. This was accompanied by evidence of activation of signal transducer and activator of transcription-1 (STAT1), STAT3, p44/42, and p38 mitogen-activated protein kinase. Tsc2−/− Eker rat embryonic fibroblasts expressed more prolactin receptor than did Tsc2+/+ cells, and responded to prolactin with increased proliferation and activation of the same signaling pathways seen in vivo.Conclusions: Prolactin may be an important growth factor in the pathogenesis of lymphangioleiomyomatosis.
Jumonji, a Nuclear Protein That Is Necessary for Normal Heart Development
Authors: Youngsook Lee, Alice J. Song, Robert Baker, Bruce Micales, Simon J. Conway, Gary E. Lyons
Journal: Circulation Research (2000)

Abstract —Jumonji ( jmj ) was cloned in a gene trap screen to identify and mutagenize genes important for heart development. To investigate the role of jmj in heart development, we generated mice homozygous for the jmj mutation. The jmj homozygous mouse embryos showed heart malformations, including ventricular septal defect, noncompaction of the ventricular wall, double-outlet right ventricle, and dilated atria. The jmj mutants died soon after birth, apparently as a result of respiratory insufficiency caused by rib and sternum defects in addition to the heart defects. In situ hybridization analyses suggested that cardiomyocytes were differentiated but developmental regulation of chamber-specific genes was defective in fetal hearts. Expression of jmj was detected in the myocardium, especially in the interventricular septum, ventricular wall, and outflow tract, which correlated well with the locations of defects observed in the hearts of mutant mice. Homozygous embryos failed to express the jmj transcript in all tissues except in the nervous system. Confocal microscopic examination using anti-JMJ antibodies indicated that the JMJ protein was localized in the nuclei of cells transfected with jmj . These data demonstrate that JMJ is a nuclear protein, which is essential for normal heart development and function.
Methylprednisolone in combination with interferon beta-1a for relapsing-remitting multiple sclerosis (MECOMBIN study): a multicentre, double-blind, randomised, placebo-controlled, parallel-group trial
Authors: Mads Ravnborg, Per Soelberg Sørensen, Magnus Andersson, Elisabeth G Celius, Peter J Jongen, Irina Elovaara, Emmanuel Bartholomé, Cris S Constantinescu, Karsten Beer, Ellen Garde, Bjørn Sperling
Journal: The Lancet Neurology (2010)
Prospective controlled trial of duplicated (J) versus quadruplicated (W) pelvic ileal reservoirs in restorative proctocolectomy for ulcerative colitis.
Authors: D Johnston, M E Williamson, W G Lewis, A S Miller, P M Sagar, P J Holdsworth
Journal: Gut (1996)

AIMS: A prospective randomised controlled trial was conducted to find out what influence the design of the pelvic reservoir had on the functional outcome. PATIENTS AND METHODS: Sixty patients received either a duplicated (J) or a quadruplicated (W) reservoir, constructed with either 30 or 40 cm of ileum. Each patient underwent laboratory tests of anorectal function before and one year after operation. RESULTS: One year after operation, 57 patients were available for assessment: each had good anal continence, though eight experienced minor leakage of mucus, and all were able to defer defecation for more than 15 minutes. Median bowel frequency in 24 hours (IQR) in patients with J reservoirs (5 (4-7)) did not differ significantly from that of patients with W reservoirs (5 (4-6)). Likewise, bowel frequency in patients with the smaller (30 cm) reservoirs did not differ significantly from bowel frequency in patients with the larger (40 cm) reservoirs. However, patients with large W40 reservoirs had the lowest bowel frequency of the four groups (median 4 per 24 hours, p = NS). The capacity and compliance of the W40 reservoirs were greater than those of the other types of reservoir, but the differences were not statistically significant. CONCLUSIONS: These findings provide support for the use of a relatively small (30 cm), duplicated (J) ileal reservoir, which is simple to construct with linear stapling instruments.
Baroreceptor control of atrioventricular conduction in man.
Authors: G Mancia, O Bonazzi, L Pozzoni, A Ferrari, M Gardumi, L Gregorini, R Perondi
Journal: Circulation Research (1979)

Although human baroreflexes are known to exert a powerful physiological control on heart rate, little information exists on the physiological control they exert on the atrioventricular conduction system. In 11 normotensive subjects with normal atrioventricular conduction, we altered baroreceptor activity by injection of pressor and depressor drugs (phenylephrine and trinitroglycerin) and recorded mean arterial pressure (MAP, catheter measurements), R-R interval, and pre-His and post-His intervals (A-H and H-V, His bundle recording). With the subjects in sinus rhythm, increasing MAP by 21+/- 1 mm Hg caused a marked lengthening (250 +/- 28 msec), and decreasing MAP by 17 +/- 2 mm Hg a marked shortening (142 +/- 16 msec) of the R-R interval. There was little change in the A-H interval and no change at all in the H-V interval. However, when the R-R interval was kept constant in these subjects by atrial pacing, a similar increase and decrease in MAP caused, respectively, a marked lengthening (49 +/- 6 msec) and shortening (19 +/- 3 msec) of the A-H interval, although the H-V interval remained unaffected. Thus physiological ranges of baroreceptor activation have a marked influence on the atrioventricular node but apparently not on the ventricular portion of the atrioventricular conduction system. This influence is unmasked when pacing prevents the baroreceptor influence on the sinoatrial node.
Species-specific and pathotype-specific binding of bacteria to zymogen granule membrane glycoprotein 2 (GP2)
Authors: Peter Schierack, Stefan Rödiger, Rafal Kolenda, Rico Hiemann, Enrico Berger, Krzysztof Grzymajło, Alexander Swidsinski, Thomas Juretzek, Dirk Meissner, Karsten Mydlak, Dirk Reinhold, Lisa K Nolan, Dirk Roggenbuck
Journal: Gut (2014)

Dear Editor,

With interest we read the paper by Juste et al 1 proposing the amount of zymogen-granule membrane glycoprotein 2 (GP2) on the surface of intestinal bacteria as a Crohn's disease (CD) marker. Indeed, a decreased GP2 level was found on microbes in patients with CD as compared to those of healthy controls. GP2 is a homologue to the urinary Tamm–Horsefall protein demonstrating an antimicrobial function by binding type 1-fimbriated uropathogenic Escherichia coli (UPEC). Likewise, GP2 seems to interact with intestinal bacteria as a specific receptor of bacterial type-1 fimbriae (FimH) on intestinal microfold cells that are partaking in immune responses against such microbes.2 GP2 is overexpressed in the inflamed intestine of patients with CD and has an immunomodulating role in innate and acquired immune responses.3 ,4 Interestingly, GP2 was identified as autoantigen of pancreatic antibodies in CD.4 Altogether, these findings indicate two major GP2 sources (pancreatic/intestinal) and support a role for GP2 in the interaction between the immune system and intestinal microbiota.3 Thus, loss of tolerance to GP2 could play a role in CD's pathophysiology supposed to be exacerbated by preceding intestinal infections. In general, the findings by Juste et al 1 may be explained by a lower pancreatic GP2 secretion, an impaired GP2 binding to bacteria, or by a higher prevalence of bacteria with poor or no GP2 binding in patients with CD.

We have a longstanding interest in GP2's intestinal function and, therefore, we evaluated GP2 as receptor for intestinal bacterial pathotypes by testing the binding of 284 bacteria in a …
Obesity and Asthma
Authors: Olga Sideleva, Benjamin T. Suratt, Kendall E. Black, William G. Tharp, Richard E. Pratley, Patrick Forgione, Oliver Dienz, Charles G. Irvin, Anne E. Dixon
Journal: American Journal of Respiratory and Critical Care Medicine (2012)

Obesity is a major risk factor for asthma; the reasons for this are poorly understood, although it is thought that inflammatory changes in adipose tissue in obesity could contribute to airway inflammation and airway reactivity in individuals who are obese.To determine if inflammation in adipose tissue in obesity is related to late-onset asthma, and associated with increased markers of airway inflammation and reactivity.We recruited a cohort of obese women with asthma and obese control women. We followed subjects with asthma for 12 months after bariatric surgery. We compared markers in adipose tissue and the airway from subjects with asthma and control subjects, and changes in subjects with asthma over time.Subjects with asthma had increased macrophage infiltration of visceral adipose tissue (P < 0.01), with increased expression of leptin (P < 0.01) and decreased adiponectin (p < 0.001) when controlled for body mass index. Similar trends were observed in subcutaneous adipose tissue. Airway epithelial cells expressed receptors for leptin and adiponectin, and airway reactivity was significantly related to visceral fat leptin expression (rho = -0.8; P < 0.01). Bronchoalveolar lavage cytokines and cytokine production from alveolar macrophages were similar in subjects with asthma and control subjects at baseline, and tended to increase 12 months after surgery.Obesity is associated with increased markers of inflammation in serum and adipose tissue, and yet decreased airway inflammation in obese people with asthma; these patterns reverse with bariatric surgery. Leptin and other adipokines may be important mediators of airway disease in obesity through direct effects on the airway rather than by enhancing airway inflammation.
The Department of Card Tricks and Close Magic
Authors: Itzhak Kronzon
Journal: Annals of Internal Medicine (2000)

On Being a Doctor19 December 2000The Department of Card Tricks and Close MagicItzhak Kronzon, MDItzhak Kronzon, MDDr. Kronzon: New York University Medical Center; New York, NY 10016Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-133-12-200012190-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail In 1974 the School of Magic Arts, directed by Mr. Frank Moreno, rented a suite at the Ramada Inn on the corner of Eighth Avenue and 52nd Street in Manhattan. I began taking classes there every Tuesday evening, in the department of card tricks and close magic. According to school regulations, beginners were not permitted to take classes in stage magic—things like sawing a woman in two, or making an elephant in a crate disappear—so I had to start on a smaller scale.Mr. Moreno was a remarkable magician and an excellent teacher of card tricks. He taught with abundant ... Author, Article, and Disclosure InformationAuthors: Itzhak Kronzon, MDAffiliations: Dr. Kronzon: New York University Medical Center; New York, NY 10016Corresponding Author: Itzhak Kronzon, MD, New YorkUniversity Medical Center, 560 First Avenue, New York, NY 10016; e-mail, Itzhak.[email protected]nyu.edu. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byApplication of magic in healthcare: A scoping review 19 December 2000Volume 133, Issue 12Page: 1005-1007KeywordsAortaCatheterizationCathetersHeartHemorrhageResearch laboratoriesSaltsStomachSurgeryVeins ePublished: 19 December 2000 Issue Published: 19 December 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...