Histiocytic Medullary Reticulosis
Authors: EDWARD C. LYNCH
Journal: Annals of Internal Medicine (1965)

Case Studies1 October 1965Histiocytic Medullary ReticulosisHemolytic Anemia Due to Erythrophagocytosis by HistiocytesEDWARD C. LYNCH, M.D., CLARENCE P. ALFREY JR., M.D.EDWARD C. LYNCH, M.D.Search for more papers by this author, CLARENCE P. ALFREY JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-4-666 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHistiocytic medullary reticulosis was first described by Scott and Robb-Smith (1) in 1939 as a disorder in which there was proliferation of actively phagocytic histiocytes in the bone marrow, spleen, liver, and lymph nodes. Based on recent reviews of the medical literature, at least 48 cases have been described (2-4); however, very few cases have been reported in the American literature (2-6). Clinically the disease is characterized by fever, wasting, generalized lymphadenopathy, hepatosplenomegaly, anemia, leukopenia, and thrombocytopenia. An increase in monocytes (1, 3, 7) and the presence of histiocytes (3, 7, 8) have occasionally been noted on examination of the...References1. SCOTTROBB-SMITH RBAH: Histiocytic medullary reticulosis. Lancet 2: 194, 1939. CrossrefGoogle Scholar2. ZAKRUBIN FGE: Histiocytic medullary reticulosis. Amer. J. Med. 31: 813, 1961. CrossrefMedlineGoogle Scholar3. GREENBERGCOHENPEASEKYLE EDMGLRA: Histiocytic medullary reticulosis. Proc. Mayo Clin. 37: 271, 1962. MedlineGoogle Scholar4. FRIEDMANSTEIGBIGEL RMNH: Histiocytic medullary reticulosis. Amer. J. Med. 38: 130, 1965. CrossrefMedlineGoogle Scholar5. BEAVERJOHNSON DCWR: A probable unusual case of Hodgkin's disease. J. Lab. Clin. Med. 19: 625, 1934. Google Scholar6. CIVINGOTSHALKOKAZAKI HHCK: Histiocyctic medullary reticulosis. Report of two cases. Arch. Intern. Med. 94: 375, 1954. 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ALFREYFULLERPITTMANCOOKRISSER CPDJPVJR: Bone marrow distribution in man. Unpublished observation. Google Scholar14. PIRCHERANDREWSBRUCERROSS FGAMDA: The Linear Scanner in Clinical Studies. U. S. Atomic Energy Commission Report, ORINS-36, August, 1960. Google Scholar15. MORRIS AC: A Linear Scanner for Human Radioisotope Research. U. S. Atomic Energy Commission Report, ORINS-33, March, 1960. Google Scholar16. LAJTHA LG: Isotope uptake of individual cells; technique for stained autoradiographs and microphotographs for grain counting. Exp. Cell Res. 3: 696, 1952. CrossrefGoogle Scholar17. ASHER R: Histiocytic medullary reticulosis. A case without lymphadenopathy. Lancet 1: 650, 1946. CrossrefMedlineGoogle Scholar18. WILLCOX DR: Haemolytic anaemia and reticulosis. Brit. Med. J. 1: 1322, 1952. CrossrefMedlineGoogle Scholar19. MARSHALL AH: Histiocytic medullary reticulosis. J. Path. Bact. 71: 61, 1956. CrossrefMedlineGoogle Scholar20. HASHIMOTO M: Pathology of bone marrow. Acta Haemat. (Basel) 27: 193, 1962. CrossrefMedlineGoogle Scholar21. HELLER JH: Cortisone and phagocytosis. Endocrinology 56: 80, 1955. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: EDWARD C. LYNCH, M.D.; CLARENCE P. ALFREYJR., M.D.Affiliations: Houston, TexasFrom the Department of Medicine, Veterans Administration Hospital, and Baylor University College of Medicine, Houston, Tex.Requests for reprints should be addressed to Edward C. Lynch, M.D., Department of Medicine, Baylor University College of Medicine, Texas Medical Center, Houston, Tex. 77025. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byErythrophagocytosis in the skin: case reportPure red cell aplasia in association with malignant histiocytosisHematologic disorders associated with cancer: I. Red blood cell disordersCytophagic histiocytic panniculitis. 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