tbuckley/cabot-search huggingface dataset:
Prandial Insulin Dosing Using the Carbohydrate Counting Technique in Hospitalized Patients With Type 2 Diabetes
Authors: Kathleen M. Dungan, Colleen Sagrilla, Mahmoud Abdel-Rasoul, Kwame Osei
Journal: Diabetes Care (2013)

OBJECTIVE To compare a modified fixed meal dosing strategy to flexible meal dosing in hospitalized patients with type 2 diabetes. RESEARCH DESIGN AND METHODS Patients (N = 126) with refractory hyperglycemia or requiring at least 20 units of insulin per day were randomly assigned to fixed meal dosing (including withholding the dose if less than half of the meal tray was consumed) or flexible meal dosing based upon carbohydrate intake. The inpatient diabetes management team made all treatment adjustments. Outcomes included day 3 mean glucose, 72-h glucose trend analysis, hypoglycemia (&amp;lt;3.9 mmol/L), and inpatient diabetes treatment satisfaction. RESULTS The mean glucose on day 3 was 9.5 and 8.8 mmol/L in the fixed and flexible meal groups, respectively (P = 0.26). The frequency of hypoglycemia was 23 and 39% overall in the fixed and flexible meal groups (P = 0.08), with half of events occurring in the morning. There was a wide range of carbohydrate intake (median 51 g/meal, 10–90% range 26–72 g on day 3). The fixed dose group required significantly more prandial insulin overall and more correction insulin over time. There was no difference in composite treatment satisfaction or dosing miscalculations between groups. CONCLUSIONS A fixed meal dosing strategy provided similar glucose control as flexible meal dosing, when managed by an inpatient diabetes treatment team. However, a larger sample size would be needed to definitively evaluate a treatment effect of flexible meal dosing in the hospital. Further study is needed to improve the delivery of bolus insulin in hospitalized patients.
TCT-709 Early and Mid-term Outcomes Of 1904 Patients Undergoing Transcatheter Balloon-Expandable Valve Implantation: results the ITER Registry
Authors: Stefano Salizzoni, Augusto D'Onofrio, Marco Agrifoglio, Antonio Colombo, Alaide Chieffo, Giuseppe Tarantini, Tommaso Regesta, Gianluca Martinelli, Davide Gabbieri, Francesco Saia, Corrado Tamburino, Flavio L. Ribichini, Diego Cugola, Marco Luigi Aiello, Alberto Boi, Alessandro Iadanza, Esmeralda Pompei, Pierlugi Stefano, Diego Ornaghi, Alessandro Minati, Andrea Agostinelli, Carla Boschetti, Audo Andrea, Francesco Casilli, Francesco Bedogni, Mauro Rinaldi
Journal: Journal of the American College of Cardiology (2014)
On the Action of Alcohol
Authors: J. Ross
Journal: BMJ (1873)

Some writers have attempted to classify insanity into emotional, ideational, impulsive, and intellectual insaniity, according to whether the case showed mor-e prominently an emotional or ideational disturb- ance, etc.I say more prominently, for there never was yet known a case in which either of these artificial divisions of mental phenomena was alone affected ; thl-brain-functions were never so dissected, as it were, by disease.Again, some autlhors divide the cases of insanity according to their supposed causes.They speak of mania d potu as a distinct malady, while others fix upon a mere concom-nitant, and describe a puerperal mania, or phthisical mania, making a mere accident the godfather to the disease;
On Lancing the Gums
Authors: E. Owen
Journal: BMJ (1884)

2w mu intrusions should take place into the profession of the law.The law as' a prfesgionin WM'&-no-iai'ic`ifd!bi&xArk i I*ori .' *hhi guarnte of qualificatious obtaine4 hy hard 4ab uv 4 muipeese, anld it would pver, v kw any trespassing,, or-any poacmf, lie.might call it,'ijpdn that learned an4most imrpotant piofes'ar.Thy was, as he thought, an unfortiisa `ttewptito'-tiespass upon the domains of the profession, and he should view anypgtteanpt of the kind with the greatest jealousy."Ile filIed the defendant £S, inctuding costs.Surely, if such remarks are applicahbl' to the profession of the law, they are.-doubly.applicabl', to that of mnediine, wem -the lives of people are at stake.I may here fitly speak of the Medical Act-Amen'dment Bill, now before Parliament, so far as. it relates to the matter I am now discuss- ing.-Whilst that Act makes it penal for any uqlified pesn to represent himself as a quaHledi Said registered p idtfners and renders it impossible for any unqualified persons to recoverifieesi:n a curt of law, it did not, appear;, until quite lately, that itmade the practice of our profession for gain by suc4x persons, incAdin: chemists, illegal.I have had' frequent corrqspondence with 'Pr: ate s, 6t' Neser, Chairman of the Parliamentary BiH1 Commitfteebi Air Aisocation', on this pbrift.Mr.; Uipton, the' Solicitor to the Association, distinctly states (JOUR1AL, vol.i, 1884, p.
Plasma Hormone Transport Proteins Revisited Part 1
Authors: Pentti K Siiteri
Journal: Endocrine Reviews (1989)

Journal Article Plasma Hormone Transport Proteins Revisited Part 1 Get access Pentti K Siiteri Pentti K Siiteri Editor Search for other works by this author on: Oxford Academic Google Scholar Endocrine Reviews, Volume 10, Issue 3, 1 August 1989, Page 231, https://doi.org/10.1210/edrv-10-3-231 Published: 01 August 1989
CARCINOMA IN THE LEOPARD FROG: ITS PROBABLE CAUSATION BY A VIRUS
Authors: Balduin Lucké
Journal: The Journal of Experimental Medicine (1938)

An epithelial tumor with acidophilic intranuclear inclusions frequently occurs in the kidneys of leopard frogs. This tumor usually has the appearance of an infiltrating and destructive adenocarcinoma, which, when large, not uncommonly metastasizes; less often it is more orderly and adenomatous. When inoculated as living fragments or cell suspensions into the lymph sacs, the cranial cavity, or the abdomen, no significant local growth results and the implanted material is resorbed. However, in approximately 20 per cent of the frogs surviving inoculation for more than 6 months, tumors develop in the kidney, which are like the "spontaneous" neoplasms. The incidence far exceeds that in the controls. Desiccated and glycerinated tumor injected into the abdomen gives the same result as inoculation with living tumor; in somewhat over 20 per cent of animals surviving more than 6 months kidney tumors occur. In alien species of frogs, no such tumors are produced by inoculation either with living or with desiccated tumor. These experiments indicate the probability that the kidney tumor of the leopard frog is caused by an inclusion-forming, organ-specific virus.
Pentamidine and Hematuria
Authors: MATTHEW SHUSTER
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 July 1986Pentamidine and HematuriaMATTHEW SHUSTER, M.D., MITCHELL DUNN, M.D.MATTHEW SHUSTER, M.D.Search for more papers by this author, MITCHELL DUNN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-105-1-146_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: A recent review on the use of pentamidine (1) outlines the frequent, though usually reversible, renal toxicity associated with this agent. We write to report the occurrence of gross hematuria associated with the administration of pentamidine.A 35-year-old man with the acquired immunodeficiency syndrome presented in August 1985 with fever and massive lymphadenopathy. Lymph node biopsy samples revealed disseminated histoplasmosis. He was treated with a 2-g course of intravenous amphotericin B and placed on maintenance therapy with ketoconazole. At the end of his therapy, symptoms and adenopathy were completely resolved and renal function was normal.The patient...References1. PEARSONHEWLETT RE. Pentamidine for the treatment of Pneumocystis carinii pneumonia and other protozoal diseases. Ann Intern Med. 1985;103:782-6. LinkGoogle Scholar2. WALZERPERLDROGSTADRAWSONSCHULTZ PDDPM. Pneumocystis carinii pneumonia in the United States: epidemiologic, diagnostic, and clinical features. Ann Intern Med. 1974;80:83-93. LinkGoogle Scholar3. STEHR-GREENHELMICK JC. Pentamidine and renal toxicity [Letter]. N Engl J Med. 1985;313:694-5. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: George Washington University Medical Center Washington, DC 20037 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited BySulfonamides, sulfadiazine, trimethoprim-sulfamethoxazole, pentamidine, pyrimethamine, dapsone, quinolonesSulfonamides, sulfadiazine, trimethoprim-sulfamethoxazole, pentamidine, pyrimethamine, dapsone, quinolonesMiscellaneous drugs with nephrotoxic potential (Sulfonamides, sulfadiazine, trimethoprim-sulfamethoxazole, pentamidine, pyrimethamine, dapsone, quinolones)Pharmacokinetics and adverse reactions after a single dose of pentamidine in patients with Trypanosoma gambiense sleeping sickness.Pneumocystis cariniiAntiprotozoal drugsInhaled or Reduced-Dose Intravenous Pentamidine for Pneumocystis carinii Pneumonia A Pilot StudyJOHN E. CONTE Jr., M.D., HARRY HOLLANDER, M.D., JEFFREY A. GOLDEN, M.D. 1 July 1986Volume 105, Issue 1Page: 146-146KeywordsAIDSAmphotericinBiopsyFeversHistoplasmosisLymph nodesToxicity Issue Published: 1 July 1986 PDF DownloadLoading ...
Neurotoxicity of Commonly Used Antineoplastic Agents
Authors: Howard D. Weiss, Michael D. Walker, Peter H. Wiernik
Journal: New England Journal of Medicine (1974)

THE incidence of neurologic disorders has been steadily increasing in several neoplastic diseases as recent advances in therapy have lengthened patient survival.1 2 3 The neurologic complications of cancer most frequently result from metastasis to the nervous system or compression of neural structures by extraneural tumor. In addition, an interesting group of nonmetastatic neuromuscular disorders has recently been described,4 , 5 and the broad concept of "carcinomatous neuromyopathy" is frequently invoked to explain obscure neurologic symptoms in patients with cancer.6 However, it is also important to realize that neurologic dysfunction may be iatrogenic — i.e., caused by the treatment of cancer. Radiation myelitis and . . .
The Utility of CPR in Elderly Persons
Authors: Mary Jo Jacobs
Journal: JAMA (1991)

To the Editor. —  The articles on life-sustaining therapies 1,2 were notable for their striking contrast in approach and conclusions. No doubt many of us had considered answers to the questions posed long before reading the results of these studies.  The results have probably done little to encourage consensus building on the subject, with their widely divergent outcomes. Is it redundant to say that age alone should not stand as an appropriate marker for defining diagnostic and treatment groups in health care except at the very macro level? We have only to look at the newborn to see that we could never place all babies in a single group in planning treatment strategies. Nor is the adolescent of 13 years predictable by age in considering degrees of sexual maturity, development, or health needs. There are many vital, healthy 75-year-olds and many weak and chronically ill 45-year-olds.  Murphy and Matchar's 1
Purification and Biochemical Characterization of Nuclear Ribonucleoprotein Antigen using Purified Antibody from Serum of a Patient with Mixed Connective Tissue Disease
Authors: Makoto Takano, Paul F. Agris, Gordon C. Sharp
Journal: Journal of Clinical Investigation (1980)

We have achieved a high degree of purification of nuclear ribonucleoprotein antigen from calf thymus nuclear extract through antibody affinity chromatography. Antibody to nuclear ribonucleoprotein was purified from the serum of a patient with mixed connective tissue disease and Sepharose 4B was covalently coupled with the purified human antibody. The sodium thiocyanate eluate from the affinity column contained active ribonucleoprotein antigen and the specific activity of the antigen in this eluate was 488 times higher than the original nuclear extract. The protein component of the eluate consisted of six polypeptides determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Two of them were shown to be antigenic by a hemagglutination inhibition test. The molecular weights of these two peptides were ∼13,000 and those of the other four were 13,000, 13,000, 30,000, and 65,000. The ribonucleic acid component of the eluate was shown by urea-polyacrylamide gel electrophoresis to contain five polynucleotides. Two of the five, estimated to contain 40 and 60 nucleosides, had antigenic activity. The other three polynucleotides which had more than 77 nucleosides had no antigenic activity. No modified nucleosides were found in these ribonucleic acid molecules. Even in this highly purified ribonucleoprotein antigen, Sm antigen was detected by immunodiffusion. This evidence indicated that there are some molecular associations between ribonucleoprotein and Sm antigens as has previously been suggested.
Lymphocyte Tubuloreticular Structures in Lupus Erythematosus
Authors: JOHN H. KLIPPEL
Journal: Annals of Internal Medicine (1974)

Lymphocytes from a series of 62 patients with systemic lupus erythematosus were examined by electronmicroscopy for the presence of tubuloreticular inclusions. Assessments were also made of selected laboratory measurements of disease activity. Inclusions correlated with activity as measured by DNA binding and erythrocyte sedimentation rate. Sequential studies permitted identification of lupus erythematosus populations that were inclusion positive, negative, or of a transitional stage. Significant differences in disease activity levels were found among these patients. Whether the inclusions are responsible for the disease fluctuations or are a secondary reflection thereof is unresolved.
Alfalfa Grass and Legume
Authors: David M. Brandenburg
Journal: JAMA (1982)

<h3>To the Editor.—</h3> A physician from Ohio requested information concerning the use of alfalfa pills in the treatment of allergies (1982;247:1493). Included in the response to this inquiry was a gross error that I believe readers should be made aware of. Dr Polk, who answered the question, stated incorrectly that alfalfa is a member of the grass family and that exposure to alfalfa may "intensify or exacerbate symptoms caused by grass pollen." Any good farmer will tell you that alfalfa is<i>not</i>a grass; indeed, it is not botanically closely related to grasses. Alfalfa belongs to the legume family and, thus, is akin to clover, beans, and peas—not to wheat, as is suggested in Dr Polk's response. He also erred in his citation of Gerrad's Food<i>Allergy: New Perspectives</i>as the source of this misinformation. On page 250 of this text, alfalfa is correctly listed as belonging to the order
Asbestos-induced Pleural Diseases - Thoracoscopic Aspects
Authors: R. Luther, K. Wetzer, W. Kühne, H. Spormann, W. Böttger
Journal: Endoscopy (1988)

The endoscopic morphology of asbestos-induced pleural disease is demonstrated by typical thoracoscopic findings. Among 627 thoracoscopies, lesions induced by exposure to asbestos were found in 9.9 % (50 malignant mesotheliomas of the pleura, 10 pleural hyalinoses, 2 asbestos pleurisies). This comparatively high percentage is indicative of the pathogenic relevance of asbestos in the pleuropulmonary region.
Peripheral vascular complications in the Coronary Angioplasty Versus Excisional Atherectomy Trial (CAVEAT-I)
Authors: Nowamagbe A. Omoigui, Robert M. Califf, Karen Pieper, Gordon Keeler, Mary Ann O'Hanesian, Lisa G. Berdan, Daniel B. Mark, J. David Talley, Eric J. Topol
Journal: Journal of the American College of Cardiology (1995)
Antibiotics in Laboratory Medicine
Authors: C. Michael Weldon-Linne
Journal: JAMA (1986)

This second edition of Dr Lorian's already-classic "silver book" is an encyclopedic compilation of current information concerning the various in vitro aspects of antimicrobial agents. One can only wonder, when perusing a volume of this scope, whether Alexander Fleming ever envisioned the revolution he started when he first described his "ditch plate" susceptibility test for the newly discovered penicillin in the years prior to World War II. This text has been updated and expanded extensively from the original 1980 edition, with seven new chapters, more than 100 new tables and illustrations, and nearly 500 more pages. The contributing authors' list reads like a "who's who" of clinical and experimental in vitro antibiotic research. These authors collectively discuss virtually every conceivable topic in their burgeoning field. The bibliographies for each chapter are compulsively comprehensive and current, with many 1984 and 1985 literature citations. The text is replete with tables, diagrams, charts,
Early-Stage Small-Bowel Adenocarcinoma: A Review of Local Endoscopic Therapy
Authors: M. Friedrich-Rust, C. Ell
Journal: Endoscopy (2005)

Early adenocarcinomas in the small intestine are a rare entity. Most adenocarcinomas in the small intestine are diagnosed at a more advanced stage. After surgical resection, only 3 - 10 % are found in stage T1 and 0 - 3 % in stage Tis (high-grade intraepithelial neoplasia), resulting in an overall 3 - 13 % rate of early-stage small-intestinal adenocarcinomas. The diagnosis of early small-intestinal carcinoma by endoscopy is still very rare, although it will propably improve with the development of new endoscopic techniques.
MORAL TREATMENT AND THE MENTAL HOSPITAL
Authors: LUCY D. OZARIN
Journal: American Journal of Psychiatry (1954)

We are perhaps now in psychiatry where physicians treating infectious disease stood before the days of antibiotics. We have relatively little in the way of weapons to attack the disease process directly. But we have acquired a vast and important knowledge of how to promote and how to provide conditions favorable for the living effort of the human organism to make itself whole. This knowledge can make the difference between very favorable and very unfavorable discharge rates. Here is a point at which the values of democracy, religion, and medicine agree—the value and dignity of the individual, the value of human understanding and of kindly relations with and assistance to another person, who must himself continue his unremitting struggle to find an adjustment and meaning in his life. While we strive to go forward toward more definitive methods of treatment, however much they may extend our success, they can never replace for the mental patient–as for the normal person–the need for understanding, constructive, human exchange.
Muscarinic regulation of cardiac L-type Ca2+ current
Authors: F Chen
Journal: Cardiovascular Research (2000)

See article by Klein et al. [1] (pages 367–374) in this issue. 

As discussed by Klein and his colleagues in this issue of Cardiovascular Research [1], cGMP is an important intracellular second messenger of various extracellular stimuli regulating L-type Ca2+ current ( I Ca-L) in both normal and failing hearts. It has been postulated that muscarinic agonists such as carbachol (CCh) bind to muscarinic receptors to promote formation of an activated inhibitory G protein–guanosine triphosphate (Gi-GTP) complex. Upon GTP binding, the heterotrimeric G protein dissociates into two moieties, Giα-GTP and Giβγ. Giα inhibits adenylyl cyclase (AC) [2,3] and decreases cyclic AMP (cAMP) concentration and thereby inhibits cAMP-dependent protein kinase (PKA). The final result is the inhibition of the phosphorylation of effectors such as the L-type Ca2+ channel ( I Ca-L). On the other hand, stimulatory receptors, such as β-adrenergic agonists, catalyze stimulatory G protein (Gs) and stimulate AC. The reaction finally increases cAMP and enhances the Ca2+ current.

However, this archetypal view has been challenged by recent studies, which suggest that muscarinic inhibition of Ca2+ channels requires the presence of the other type of G (Go) protein [4], since there is a specific defect in muscarinic regulation of Ca2+ current in Goα knockout (Goα−/−) mouse ventricular myocytes. It has also been revealed that nitric oxide (NO) and cyclic guanosine monophosphate (cGMP) play important roles in muscarinic regulation of cardiac I Ca-L. But the details of muscarinic regulation in cardiac I Ca-L is not completely understood. … 

* Tel.: +1-310-825-7105; fax: +1-310-825-7458 fchen{at}mednet.ucla.edu
Therapeutic Interventions for Systemic Vasculitis
Authors: Gary S. Hoffman
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Book Review Cell Biology of Addiction Edited by Bertha K. Madras, Christine M. Colvis, Jonathan D. Pollock, Joni L. Rutter, David Shurtleff, and Mark von Zastrow. 465 pp., illustrated. Cold Spring Harbor, N.Y., Cold Spring Harbor Laboratory Press, 2006. $125. 0-87969-753-9
Authors: Peter R. Martin
Journal: New England Journal of Medicine (2006)
US Citizens and Foreign Medical Schools
Authors: Richard L. Egan
Journal: JAMA (1975)

The foreign medical schools that are accepting an increasing number of applicants rejected by US medical schools are not comparable to US medical schools. Until population trends lessen the number seeking a medical education, several pathways are available to identify and assist the qualified student to return to US medicine. (<i>JAMA</i>232:1028-1030, 1975)