Cardiovascular Risk Factors in Severely Obese Adolescents
Authors: Marc P. Michalsky, Thomas H. Inge, Mark Simmons, Todd M. Jenkins, Ralph Buncher, Michael Helmrath, Mary L. Brandt, Carroll M. Harmon, Anita Courcoulas, Michael Chen, Mary Horlick, Stephen R. Daniels, Elaine M. Urbina
Journal: JAMA Pediatrics (2015)

<h3>Importance</h3> Severe obesity is increasingly common in the adolescent population but, as of yet, very little information exists regarding cardiovascular disease (CVD) risks in this group. <h3>Objective</h3> To assess the baseline prevalence and predictors of CVD risks among severely obese adolescents undergoing weight-loss surgery. <h3>Design, Setting, and Participants</h3> A prospective cohort study was conducted from February 28, 2007, to December 30, 2011, at the following 5 adolescent weight-loss surgery centers in the United States: Nationwide Children's Hospital in Columbus, Ohio; Cincinnati Children's Hospital Medical Center in Cincinnati, Ohio; Texas Children's Hospital in Houston; University of Pittsburgh Medical Center in Pittsburgh, Pennsylvania; and Children's Hospital of Alabama in Birmingham. Consecutive patients aged 19 years or younger were offered enrollment in a long-term outcome study; the final analysis cohort consisted of 242 participants. <h3>Main Outcomes and Measures</h3> This report examined the preoperative prevalence of CVD risk factors (ie, fasting hyperinsulinemia, elevated high-sensitivity C-reactive protein levels, impaired fasting glucose levels, dyslipidemia, elevated blood pressure, and diabetes mellitus) and associations between risk factors and body mass index (calculated as weight in kilograms divided by height in meters squared), age, sex, and race/ethnicity. Preoperative data were collected within 30 days preceding bariatric surgery. <h3>Results</h3> The mean (SD) age was 17 (1.6) years and median body mass index was 50.5. Cardiovascular disease risk factor prevalence was fasting hyperinsulinemia (74%), elevated high-sensitivity C-reactive protein levels (75%), dyslipidemia (50%), elevated blood pressure (49%), impaired fasting glucose levels (26%), and diabetes mellitus (14%). The risk of impaired fasting glucose levels, elevated blood pressure, and elevated high-sensitivity C-reactive protein levels increased by 15%, 10%, and 6%, respectively, per 5-unit increase in body mass index (<i>P</i> &lt; .01). Dyslipidemia (adjusted relative risk = 1.60 [95% CI, 1.26-2.03];<i>P</i> &lt; .01) and elevated blood pressure (adjusted relative risk = 1.48 [95% CI, 1.16-1.89];<i>P</i> &lt; .01) were more likely in adolescent boys compared with adolescent girls. White individuals were at greater risk of having elevated triglyceride levels (adjusted relative risk = 1.76 [95% CI, 1.14-2.72];<i>P</i> = .01) but were less likely to have impaired fasting glucose levels (adjusted relative risk = 0.58 [95% CI, 0.38-0.89];<i>P</i> = .01). <h3>Conclusions and Relevance</h3> Numerous CVD risk factors are apparent in adolescents undergoing weight-loss surgery. Increasing body mass index and male sex increase the relative risk of specific CVD risk factors. These data suggest that even among severely obese adolescents, recognition and treatment of CVD risk factors is important to help limit further progression of disease.