Ampicillin in the Treatment of Enterococcal Endocarditis
Authors: HARRY N. BEATY
Journal: Annals of Internal Medicine (1966)

Article1 October 1966Ampicillin in the Treatment of Enterococcal EndocarditisHARRY N. BEATY, M.D., MARVIN TURCK, M.D., ROBERT G. PETERSDORF, M.D., F.A.C.P.HARRY N. BEATY, M.D.Search for more papers by this author, MARVIN TURCK, M.D.Search for more papers by this author, ROBERT G. PETERSDORF, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-4-701 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe currently recommended treatment for enterococcal endocarditis consists of high doses of aqueous penicillin intravenously, given in combination with intramuscular streptomycin for 6 weeks (1). If antibiotic dosage is regulated to maintain a constant bactericidal activity against the infecting strain in at least a 1:4 dilution of the patient's serum, the bacteriologic cure rate for this infection approaches that achieved for highly penicillin-sensitiveStreptococcus viridansendocarditis (1, 2). Although the penicillin-streptomycin regimen is eminently satisfactory from the therapeutic point of view, it involves considerable inconvenience, cost, and the potential risk of ototoxicity. For these reasons, it seems reasonable to seek...References1. KOENIGKAYE MGD: Enterococcal endocarditis. Report of nineteen cases with long-term follow-up data. New Eng. J. Med. 264: 257, 1961. CrossrefMedlineGoogle Scholar2. GERACI JE: Antibiotic therapy of bacterial endocarditis: therapeutic data on 172 patients seen from 1951 through 1957: additional observations on short term therapy (two weeks) for penicillin-sensitive streptococcal endocarditis. Med. Clin. N. Amer. 42: 1101, 1958. CrossrefMedlineGoogle Scholar3. FINLAND M: Treatment of bacterial endocarditis. New Eng. J. Med. 250: 372, 1954. CrossrefMedlineGoogle Scholar4. JAWETZGUNNISON EJB: The determination of sensitivity to penicillin and streptomycin of enterococci and streptococci of the viridans group. J. Lab. Clin. Med. 35: 488, 1950. Google Scholar5. BLOUNT JG: Bacterial endocarditis. Amer. J. Med. 38: 909, 1965. CrossrefMedlineGoogle Scholar6. MCCARTHYFINLAND CGM: Absorption and excretion of four penicillins: penicillin G, penicillin V, phenethicillin and phenylmercaptomethyl penicillin. New Eng. J. Med. 263: 315, 1960. CrossrefGoogle Scholar7. SCHLICHTERMACLEANMILZER JGHA: Effective penicillin therapy in subacute bacterial endocarditis and other chronic infections. Amer. J. Med. Sci. 217: 600, 1949. CrossrefMedlineGoogle Scholar8. JACKSONRUBENISKENNEDY GGMRP: Comparison of three penicillins against microorganisms causing bacterial endocarditis with some clinical observations on phenethicillin, in Antimicrobial Agents and Chemotherapy, edited by FINLAND, M., SAVAGE, G. M. Braun-Brumfield, Inc., Ann Arbor, 1961, p. 697. Google Scholar9. HUNTER TH: The treatment of subacute bacterial endocarditis with antibiotics. Amer. J. Med. 1: 83, 1946. CrossrefMedlineGoogle Scholar10. HUNTER TH: Speculations on the mechanism of cure of bacterial endocarditis. JAMA 144: 524, 1950. CrossrefMedlineGoogle Scholar11. ROBBINSTOMPSETT WCR: Treatment of enterococcal endocarditis and bacteremia: results of combined therapy with penicillin and streptomycin. Amer. J. Med. 10: 278, 1951. CrossrefMedlineGoogle Scholar12. ROLINSONSTEVENS GNS: Microbiological studies on a new broad-spectrum penicillin, "Penbritin." Brit. Med. J. 2: 191, 1961. CrossrefMedlineGoogle Scholar13. QUINNCOLVILLEBALLARDJONESDEBNAM ELJMLDF: Ampicillin: antimicrobial activity and pharmacological behavior with reference to certain gram-positive cocci, in Antimicrobial Agents and Chemotherapy, edited by SYLVESTER, J. C. Braun-Brumfield, Inc., Ann Arbor, 1962, p. 339. Google Scholar14. STEWARTCOLESNIXONHOLT GTHMHHRJ: "Penbritin": an oral penicillin with broad spectrum activity. Brit. Med. J. 2: 200, 1961. CrossrefMedlineGoogle Scholar15. JONES A: The activity of ampicillin and phenethicillin for bacteria isolated from veterinary sources. J. Comp. Path. Ther. 24: 129, 1964. CrossrefGoogle Scholar16. RUTENBERGGREENBERGSCHWEINBURGPERREAULT AMHLFBMA: Studies on alpha-aminobenzyl penicillin, in Antimicrobial Agents and Chemotherapy, edited by FINLAND M., SAVAGE, G. M. Braun-Brumfield, Inc., Ann Arbor, 1961, p. 748. Google Scholar17. HOLLOWAYPETERSSCOTT WJCDEG: Clinical experience with oral and parenteral ampicillin, in Antimicrobial Agents and Chemotherapy, edited by SYLVESTER, J. C. Braun-Brumfield, Inc., Ann Arbor, 1963, p. 314. Google Scholar18. STRATFORD BC: Clinical and laboratory experiences with ampicillin ("Penbritin"). Med. J. Aust. 49(2): 414, 1962. CrossrefMedlineGoogle Scholar19. GRAYTAIWALLACECALDER IRARJGJH: Oral treatment of bacterial endocarditis with penicillins. Lancet 2: 110, 1964. CrossrefMedlineGoogle Scholar20. BURNELL RH: The successful treatment of a case of bacterial endocarditis with ampicillin. Med. J. Aust. 2: 60, 1964. CrossrefMedlineGoogle Scholar21. BUNNO'BRIENBENTLEYHAYMAN PJDH: Further experiences with ampicillin, in Antimicrobial Agents and Chemotherapy, edited by SYLVESTER, J. C. Braun-Brumfield, Inc., Ann Arbor, 1962, p. 323. Google Scholar22. LLOYD-STILL JD: Bacterial endocarditis and urology. Brit. Med. J. 1: 768, 1965. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: HARRY N. BEATY, M.D.; MARVIN TURCK, M.D.; ROBERT G. PETERSDORF, M.D., F.A.C.P.Affiliations: Seattle, WashingtonFrom the Department of Medicine, University of Washington School of Medicine, and King County Hospital, Seattle, Wash.This study was supported in part by a grant from the Boeing Good Neighbor Fund.Requests for reprints should be addressed to Harry N. Beaty, M.D., King County Hospital, 325 9th Ave., Seattle, Wash. 98104. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHow do I manage a patient with enterococcal bacteraemia?Combination Therapy for Enterococcal EndocarditisEnterococcal Endocarditis on Native and Prosthetic ValvesContinuous intravenous versus intermittent ampicillin therapy of experimental endocarditis caused by aminoglycoside-resistant enterococciScreening and treatment of infections caused by resistant enterococciThe life and times of the EnterococcusAortic endocarditis caused by gentamicin-resistantEnterococcus faecalisContinuous-infusion ampicillin therapy of enterococcal endocarditis in ratsAmpicillin therapy of experimental enterococcal endocarditisComparative Activity of Amoxycillin, Ampicillin and Benzylpenicillin Against Streptococci Causing Bacterial EndocarditisStreptococcal infections—UpdatedEffect of pH and Human Serum on the Susceptibility of Group D Streptococci (Enterococci) to Ampicillin In VitroBacterial endocarditis in regularly dialyzed patientsIn Vitro Activity of Ampicillin or Vancomycin Combined with Gentamicin or Streptomycin Against EnterococciChanges in the Spectrum, Diagnosis, and Management of Bacterial and Fungal EndocarditisAmpicillinThe Present Status of Streptomycin in Antimicrobial TherapyAntimicrobial agentsThe Changing Pattern of Bacterial EndocarditisComparison of the Action of Ampicillin and Benzylpenicillin on Enterococci In VitroDosage and Mode of AdministrationNewer PenicillinsACTIVITY OF BROAD-SPECTRUM ANTIBIOTICS AGAINST ENTEROCOCCI AND THEIR EFFICACY IN ENTEROCOCCAL ENDOCARDITISInfectious diseases. Annual review of significant publications 1 October 1966Volume 65, Issue 4Page: 701-707KeywordsEndocarditisEnterococcus infectionsHospital medicinePenicillinStreptococcal infectionsStreptococcusStreptomycin ePublished: 1 December 2008 Issue Published: 1 October 1966 PDF downloadLoading ...