Response to Repeated Platelet Transfusion from the Same Donor
Authors: EMIL J. FREIREICH
Journal: Annals of Internal Medicine (1963)

Article1 September 1963Response to Repeated Platelet Transfusion from the Same DonorEMIL J. FREIREICH, M.D., ALLAN KLIMAN, M.D., LAWRENCE A. GAYDOS, M.D., NATHAN MANTEL, M.A., EMIL FREI III, M.D.EMIL J. FREIREICH, M.D., ALLAN KLIMAN, M.D., LAWRENCE A. GAYDOS, M.D., NATHAN MANTEL, M.A., EMIL FREI III, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-59-3-277 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMore than a half century has passed since Duke (2) demonstrated that transfusion of platelets to thrombocytopenic patients could raise the circulating platelet count and arrest hemorrhage. These observations have been repeatedly confirmed in man and experimental animals (3-6). Nevertheless, platelet transfusion therapy is not widely practiced but is reserved for short-term treatment of thrombopenia associated with serious hemorrhage or for preoperative use (3-5, 7). A major reason for this is an inadequate supply of platelets for transfusion. The short platelet life-span of 5 to 8 days necessitates frequent transfusions, and because no effective storage technique is known, only freshly...References1. FREIREICHKLIMANGAYDOSSCHROEDER EJALALR: Response to repeated platelet transfusions from the same donor. J. Clin. Invest. 40: 1039, 1961. Google Scholar2. DUKE WW: The relation of blood platelets to hemorrhagic disease: description of a method for determining the bleeding time and the coagulation time and report of three cases of hemorrhagic disease relieved by transfusion. JAMA 55: 1185, 1910. CrossrefGoogle Scholar3. FARBERKLEIN SE: The nature and control of bleeding in acute leukemia and other thrombocytopenic states. Ann. Paediat. Fenn. 3: 348, 1957. MedlineGoogle Scholar4. CRONKITEJACKSON EPDP: Use of platelet transfusions in hemorrhagic disease, in Progress in Hematology, Vol. II, Grune and Stratton, Inc., New York, 1959, p. 239. 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Invest. 40: 1597, 1961. CrossrefMedlineGoogle Scholar22. SILVERUTZFAHEYFREI RTJPJE: Antibody response in patients with acute leukemia. J. Lab. Clin. Med. 56: 634, 1960. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Bethesda, MarylandFrom the National Cancer Institute and the Division of Biologic Standards, National Institutes of Health, Bethesda, Maryland.An abstract of this paper has been previously published (1).Requests for reprints should be addressed to Emil J. Freireich, M.D., National Institutes of Health, Bethesda, Maryland. 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YANKEE, M.D.Circulation of Concentrated One-day-old Platelets in VivoPlatelet Transfusion TherapyLITERATURVERZEICHNISBIBLIOGRAPHYDie Thrombozyten-TransfusionClinical Effectiveness of Platelet Concentrates Prepared with or without Acidification of the PlasmaTherapy for Blood Disorders in Infants and ChildrenThe use of an isolator system in cancer chemotherapyTransfusion of Fresh Platelet Concentrates to Adult Patients with ThrombocytopeniaStructure-Activity Analysis of Tetrahydrofolate Analogs Using Substituent Constants and Regression AnalysisEffect of platelet transfusion on hemorrhage in patients with acute leukemia: An autopsy studyPlatelet TransfusionPreparation and in Vivo Circulation of Human Platelets Preserved with Combined Dimethylsulfoxide and DextroseThe Use of Platelet TransfusionsTransfusion of Platelet Concentrates Prepared from Acidified Platelet-Rich PlasmaPlatelet PreservationPulmonary complications of acute leukemiaPreparation of Platelet Concentrates for Transfusion Employing Adenosine DiphosphateThe Anticoagulants of Choice for Platelet TransfusionsImmunological Considerations Attending Platelet TransfusionEffectiveness of Platelet Transfusion in Leukemia and Aplastic AnemiaThe Role of Platelet Administration in a Blood Transfusion ServicePhysiologic Observations in Human Cross CirculationPlatelet PreservationBreast Cancer Combined Clinical Staff Conference at the National Institutes of HealthNATHANIEL I. BERLIN, M.D., HOWARD B. ANDERVONT, D.SC., MICHAEL B. SHIMKIN, M.D., B. J. KENNEDY, M.D., EMIL FREI III, M.D.Response to Transfusion of Platelets Pooled from Multiple Donors and the Effects of Various Technics of Concentrating PlateletsProgress and Perspectives in the Chemotherapy of Acute LeukemiaThe Gastrointestinal Lesions and Complications of the LeukemiasJ. C. PROLLA, M.D., JOSEPH B. KIRSNER, M.D., F.A.C.P.Complement-Fixing Platelet Iso-Antibodies in Serum of Transfused Persons. Correlation of Antibodies with Platelet Survival in Thrombocytopenic PatientsEffect of Storage up to 48 Hours on Response to Transfusions of Platelet Rich PlasmaQuantitative Concepts in the Clinical Study of Drugs 1 September 1963Volume 59, Issue 3Page: 277-287KeywordsBiologicsBlood plasmaHemorrhagePlateletsSepsisThrombocytopenia Issue Published: 1 September 1963 PDF DownloadLoading ...