tbuckley/cabot-search huggingface dataset:
The treatment of visible signs of senescence: the Italian experience
Authors: R. CAPUTO, M. MONTI, S. MOTTA, M. BARBARESCHI, A. TOSTI, R. SERRI, C. RIGONI
Journal: British Journal of Dermatology (1990)

Journal Article The treatment of visible signs of senescence: the Italian experience Get access R. CAPUTO, R. CAPUTO Department of Dermatology, University of Milan, Italy Dr R. Caputo, Instituto Di Clinica Dermatologia, Via Pace 9, 20122 Milan, Italy. Search for other works by this author on: Oxford Academic Google Scholar M. MONTI, M. MONTI Department of Dermatology, University of Milan, Italy Search for other works by this author on: Oxford Academic Google Scholar S. MOTTA, S. MOTTA Department of Dermatology, University of Milan, Italy Search for other works by this author on: Oxford Academic Google Scholar M. BARBARESCHI, M. BARBARESCHI Department of Dermatology, University of Milan, Italy Search for other works by this author on: Oxford Academic Google Scholar A. TOSTI, A. TOSTI Department of Dermatology, University of Bologna, Italy Search for other works by this author on: Oxford Academic Google Scholar R. SERRI, R. SERRI Department of Dermatology, University of Milan, Italy Search for other works by this author on: Oxford Academic Google Scholar C. RIGONI C. RIGONI Department of Dermatology, University of Milan, Italy Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 122, Issue s35, 1 April 1990, Pages 97–103, https://doi.org/10.1111/j.1365-2133.1990.tb16133.x Published: 01 April 1990
The Value of Imaging in Standing Position in Preoperative Breast Lymphoscintigraphy
Authors: Christos Anagnostou, Cinzia Baiocco, Alberto Arnulfo, Mauro Liberatore, Anna Maria Baccheschi, Eugenio Inglese
Journal: Clinical Nuclear Medicine (2011)

Breast lymphoscintigraphy is an accurate technique, but in a minority of cases the sentinel node (SN) visualization cannot be achieved or can be very difficult. We evaluated the potential clinical advantages and limitations of performing imaging in the standing position. The aim was to establish if this examination modality is quicker and helpful in the presence of "hidden" SN, checking also for any influence of SN skin landmarking in the upright position on the correct intraoperative SN identification. The overall objective was to verify if the standing position can be routinely used in breast lymphoscintigraphy.A total of 144 patients underwent lymphoscintigraphy in both standing and supine positions. In both modalities, a skin landmark was set coincident with the SN orthogonal projections. The acquisition times of 2 groups (each consisting of 45 patients) examined with the standing or supine acquisition modality, were compared.In 6 cases with hidden SN and in 34 cases with difficult or partial visualization in one of the supine views, the standing protocol was effective and led to better and quicker visualization of lymph nodes (median examination time: 25.5 minutes standing, 35.5 minutes supine). Significant differences in skin landmark position between the 2 modalities were present only in overweight patients and in large breasts. This, however, did not have a negative impact on successful intraoperative localization of SN with the gamma probe.Standing acquisition resulted to be a faster, easier, and more accurate examination protocol and can be used as the routine method for SN detection in breast lymphoscintigraphy.
101 INCIDENCE RATES AND RISK FACTORS ASSOCIATED WITH HEPATOCELLULAR CARCINOMA (HCC) IN PATIENTS WITH ADVANCED LIVER DISEASE DUE TO HEPATITIS C: RESULTS OF THE HALT-C TRIAL
Authors: A.S. Lok, L.B. Seeff, T.R. Morgan, A.M. DiBisceglie, R.K. Sterling, T.M. Curto
Journal: Journal of Hepatology (2008)
In praise of medical secretaries: Pay and conditions should reflect crucial role of medical secretaries in clinical teams
Authors: A. R L Medford
Journal: BMJ (2003)

EDITOR–Medical secretaries are pivotal members of the clinical team in both primary and secondary care.1 Unfortunately they are usually conspicuous only in the event of mistakes, as with many other healthcare professionals.

The crucial role of medical secretaries seems to be barely recognised. Even more …
Sonnet, status post-mastectomy
Authors: Ronald Pies
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 3251: Linking prostaglandin E2 signaling, lipid rafts, and DNA protein kinase
Authors: Ernest T. Hawk, David G. Menter, Sherri Patterson, Michael W. Swank, Raymond N. DuBois
Journal: Cancer Research (2012)

Abstract Colorectal cancer (CRC) is the second-leading cause of death from cancer in the USA. Chronic inflammation in the gastrointestinal tract is a significant risk factor for developing CRC. Generally, CRC involves the upregulation of inflammation-induced cyclooxygenase-2 (COX-2) that is blocked by non-steroidal anti-inflammatory drugs (NSAIDS). Among the downstream prostaglandin synthases that produce bioactive prostaglandins (PGs), prostaglandin E2 (PGE2) synthase products are proinflammatory. After export from cells, PGE2 can bind to G-protein coupled PG cell surface receptors EP2/4 and activate adenylate cyclase and elevate cAMP. In turn, cAMP activates downstream effectors such as protein kinase A (PKA) and/or exchange protein directly activated by cAMP (EPAC). We studied effects of PGE2 on PKA activation in CRC cells and their relationship to lipid raft function. After isolating lipid rafts from PGE2 stimulated cells we performed shotgun proteomics. Among the lipid raft proteins identified were DNA-protein kinase (DNA-PK), and heterodimer complex proteins Ku70 and Ku80, which we verified by immunoprecipitation and immunofluorescence. Of these lipid raft proteins, Ku80 contained a PKA consensus phosphorylation sites and phosphorylation increased after stimulation of CRC cells by PGE2. Typically found in the nucleus, Ku70, Ku80 and DNA-PK complexes bind to DNA double-strand breaks and initiate non-homologous end joining DNA repair. These data are the first to demonstrate the Ku70, Ku80 and DNA-PK complexes in a new non-nuclear action, which involves lipid rafts and the DNA repair complex. Furthermore, PGE2 stimulated LS174T CRC cells exhibit an increase in non-nuclear pDNA-PK (S2056). Additionally, treatment of a number of colon cancer cell lines with the selective DNA-PK inhibitor Nu7026 significantly decreased cell viability in the absence of any overt DNA damaging stimuli, suggesting that non-nuclear, and in particular, lipid raft localized DNA-PK complex may play an important role in cell growth. Finally, treatment with both PGE2 and Nu7026 causes a profound change in cell morphology involving numerous spindle-like processes. These data suggest there are important downstream effects of proinflammatory PGE2 on CRC cells that influence lipid raft associated Ku70, Ku80 and DNA-PK complexes as well as cell proliferation. Support: T. Boone Pickens Distinguished Chair for Early Prevention of Cancer to E.T.H., R37 DK47297, NCI P01 CA77839, CPRIT-RP100960, Ellen F. Knisely Distinguished Chair in Colon Cancer Research, The National Colorectal Cancer Research Alliance to R.N.D. and 5U54CA151668-02 to D.G.M. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3251. doi:1538-7445.AM2012-3251
Medical Ground Zero: An Early Experience of the World Trade Center Disaster
Authors: Mack Lipkin
Journal: Annals of Internal Medicine (2002)

On Being a Doctor7 May 2002Medical Ground Zero: An Early Experience of the World Trade Center DisasterMack Lipkin Jr., MDMack Lipkin Jr., MDDr. Lipkin: New York University School of Medicine; Bellevue Hospital CenterAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-136-9-200205070-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail 11 September 20018:50 a.m.: Our pregnant chief resident says, "Did you see the World Trade Center is smoking?"For years the twin towers of the World Trade Center had guarded Bellevue Hospital's southern horizon.9:03 a.m.: The second tower explodes with flame and smokes heavily, like an upward mudslide. From my wife, "… we are okay, I saw the smoke, I'll be in touch."10:05 a.m.: The south tower collapses.One chief tells me of a senior resident who won't leave her home, distraught because her fiancé works at the World Trade Center and she can't reach him. I ... Author, Article, and Disclosure InformationAffiliations: Dr. Lipkin: New York University School of Medicine; Bellevue Hospital CenterAcknowledgments: The author thanks the housestaff, chief residents, attendings, and students at Bellevue, New York University Medical Center, and New York University Downtown Hospital; and his wife, Ellen, and his daughter, Annarose, who made participating with them in the response to 9/11 inspiring and informative. He is deeply grateful for the privilege of their support in this tragic time. Drs. Dana Rathkopf, David S. Goldfarb, Michael Weiden, Merdad Parsey, Nate Link, Mitchell Charap, Norma Keller, Eric Manheimer, Kathleen McGrail, and Lloyd Wasserman contributed to what is true in the article but not to its errors.Corresponding Author: Mack Lipkin Jr., MD, Division of Primary Care, Department of Medicine, NBV 16510, New York University Medical Center, 550 First Avenue, New York, NY 10016; e-mail, [email protected]med.nyu.edu. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRecruiting students for the COVID-19 emergency response: lessons from eight African countriesConnecting with others in the midst of stressful upheaval on September 11, 2001Management of mass casualty burn disastersDisaster preparation and management for the intensive care unit 7 May 2002Volume 136, Issue 9Page: 704-707KeywordsFearFoodInhalationPregnancySleepSmellSurgeryTouchTriageTwins ePublished: 7 May 2002 Issue Published: 7 May 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Prostaglandin-Producing Suppressor Cells in Hodgkin's Disease
Authors: James S. Goodwin, Ronald P. Messner, Arthur D. Bankhurst, Glenn T. Peake, John H. Saiki, Ralph C. Williams
Journal: New England Journal of Medicine (1977)

We examined the role of a prostaglandin producing suppressor cell in the hyporesponsiveness to phytohemagglutinin seen in Hodgkin's disease. Addition of indomethacin to phytohemagglutinin cultures of lymphocytes from six patients with Hodgkin's disease resulted in an increase of 182±60 per cent in 3H-thymidine incorporation versus a 44±18 per cent increase in 29 controls (mean ± S.D., P<0.001). Without indomethacin the mean response of the lymphocytes in Hodgkin's disease was 48 per cent of that of control. With indomethacin it was 94 per cent of the control value. Phytohemagglutinin cultures of Hodgkin-disease lymphocytes produced approximately fourfold more prostaglandin E2 after 48 hours than did normal lymphocytes (P<0.02). Removal of glass-adherent cells markedly decreased the enhancement seen with indomethacin; it reduced prostaglandin E2 production by more than 80 per cent and eliminated the differences in response to phytohemagglutinin between Hodgkin-disease and normal lymphocytes. Thus, a glass-adherent, prostaglandin-producing suppressor cell is responsible for the hyporesponsiveness to phytohemagglutinin seen with Hodgkin-disease lymphocytes. (N Engl J Med 297:963–968, 1977)
Lipid Rafts and Nonrafts Mediate Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand–Induced Apoptotic and Nonapoptotic Signals in Non–Small Cell Lung Carcinoma Cells
Authors: Jin H. Song, Margaret C.L. Tse, Anita Bellail, Surasak Phuphanich, Fadlo Khuri, Norman M. Kneteman, Chunhai Hao
Journal: Cancer Research (2007)

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is capable of inducing apoptosis in non-small cell lung carcinoma (NSCLC). However, many of the human NSCLC cell lines are resistant to TRAIL, and TRAIL treatment of the resistant cells leads to the activation of nuclear factor-kappaB (NF-kappaB) and extracellular signal-regulated kinase 1/2 (ERK1/2). TRAIL can induce apoptosis in TRAIL-sensitive NSCLC cells through the induction of death-inducing signaling complex (DISC) assembly in lipid rafts of plasma membrane. In the DISC, caspase-8 is cleaved and initiates TRAIL-induced apoptosis. In contrast, TRAIL-DISC assembly in the nonraft phase of the plasma membrane leads to the inhibition of caspase-8 cleavage and NF-kappaB and ERK1/2 activation in TRAIL-resistant NSCLC cells. Receptor-interacting protein (RIP) and cellular Fas-associated death domain-like interleukin-1beta-converting enzyme-inhibitory protein (c-FLIP) mediates the DISC assembly in nonrafts and selective knockdown of either RIP or c-FLIP with interfering RNA redistributes the DISC from nonrafts to lipid rafts, thereby switching the DISC signals from NF-kappaB and ERK1/2 activation to caspase-8-initiated apoptosis. Chemotherapeutic agents inhibit c-FLIP expression, thereby enhancing the DISC assembly in lipid rafts for caspase-8-initiated apoptosis. These studies indicate that RIP and c-FLIP-mediated assembly of the DISC in nonrafts is a critical upstream event in TRAIL resistance and thus targeting of either RIP or c-FLIP may lead to the development of novel therapeutic strategies that can overcome TRAIL resistance in human NSCLC.
The presence of autoantibody to recombinant lipocortin-I in patients with psoriasis and psoriatic arthritis
Authors: J.K. RIVERS, M.R. PODGORSKI, N.J. GOULDING, E. WONG, J.A. MCGRATH, R.J. FLOWER, M.W. GREAVES
Journal: British Journal of Dermatology (1990)

Corticosteroids may mediate some of their anti-inflammatory effects via induction of a specific 38 kDa protein, lipocortin-I. Anti-lipocortin-I antibodies (ALA) were measured by enzyme-linked immunosorbent assay (ELISA) in 23 patients with plaque-type psoriasis alone (NAP), in 21 patients with psoriasis and arthritis (PA), and in 67 healthy controls. Only two of 23 NAP patients had elevated ALA, whereas six of 21 PA patients had raised levels of ALA (P = 0.2). Sero-negative polyarthritis was the most common pattern of joint disease in those PA patients with elevated ALA (4/6). ALA levels did not correlate with the extent or severity of cutaneous involvement, and are unlikely to be involved in the pathogenesis of cutaneous psoriasis.
"A little white tablet, doctor"
Authors: M. Turner
Journal: BMJ (2002)

Few doctors will not recognise this reply from patients asked to recall their medication. After a similarly vague history of presenting complaint, a persistent clinician might try to narrow down what the tablet is prescribed for, at least, though often (and alarmingly perhaps) this is often a fruitless exercise. There can be occasions, however, when the colour is the key after all.

When I was a senior house officer working in accident and emergency I was asked to take a telephone …
THE REACTIONS BETWEEN BACTERIA AND ANIMAL TISSUES UNDER CONDITIONS OF ARTIFICIAL CULTIVATION
Authors: Henry Field Smyth
Journal: The Journal of Experimental Medicine (1916)

In plasma cultures, with or without tissue, tubercle bacilli form characteristic streptothrix-like colonies of loosely twisted skeins of threads. In plasma tissue cultures embryonal connective tissue and epithelial cells phagocytyze tubercle bacilli freely. Splenic tissue cultures from fourteen day or older embryos if inoculated with isolated bacilli will phagocytyze and prevent the development of all or nearly all bacilli present. If heavy inoculations of tubercle bacilli with many bacillary clumps are made in splenic cultures the bacilli develop more freely than in similar connective tissue cultures from heart tissue in spite of marked phagocytosis. In such cultures the first change seen is a clustering of small round cells, interpreted as lymphocytes, around bacillary clumps and colonies followed by a similar clustering of larger parenchymatous polygonal cells with one or several nuclei, interpreted as epithelioid cells, which phagocytyze any bacilli with which they may come in contact. The larger cells containing bacilli then fuse to form larger multinuclear cells and these by further fusion form typical giant cells with quiescent nuclei in characteristic groupings and bacilli in degenerated protoplasm away from the nuclear groups. Cells which have phagocytyzed bacilli may digest them or may be unable to do so, in which case the bacilli develop within the cells and eventually cause complete cell degeneration.
Deprivation and cause specific morbidity: evidence from the Somerset and Avon survey of health
Authors: J. Eachus, M. Williams, P. Chan, G. D. Smith, M. Grainge, J. Donovan, S. Frankel
Journal: BMJ (1996)

To investigate the association between cause specific morbidity and deprivation in order to inform the debates on inequalities in health and health services resource allocation.Cross sectional postal questionnaire survey ascertaining self reported health status, with validation of a 20% sample through general practitioner and hospital records.Inner city, urban, and rural areas of Avon and Somerset.Stratified random sample of 28,080 people aged 35 and over from 40 general practices.Age and sex standardised prevalence of various diseases; Townsend deprivation scores were assigned by linking postcodes to enumeration districts. Relative indices of inequality were calculated to estimate the magnitude of the association between socioeconomic position and morbidity.The response rate was 85.3%. The prevalence of most of the conditions rose with increasing material deprivation. The relative index of inequalilty, for both sexes combined, was greater than 1 for all conditions except diabetes. The conditions most strongly associated with deprivation were diabetic eye disease (relative index of inequality 3.21; 95% confidence interval 1.84 to 5.59), emphysema (2.72; 1.67 to 4.43) and bronchitis (2.27; 1.92 to 2.68). The relative index of inequality was significantly higher in women for asthma (P < 0.05) and in men for depression (P < 0.01). The mean reporting of prevalent conditions was 1.07 for the most deprived fifth of respondents and 0.77 in the most affluent fifth (P < 0.001).Material deprivation is strongly linked with many common diseases. NHS resource allocation should be modified to reflect such morbidity differentials.
1074-154 Contrast-enhanced echocardiography improves agreement on the assessment of ejection fraction and left ventricular volumes: A multicenter study
Authors: Rainer Hoffmann, Adrian Borges, Jaroslaw Kasprzak, Christian Firschke, Stephane Lafitte, Nidal Al-Saadi, Folkert ten Cate, Stefanie Kuntz-Hehner, Marc Engelhardt, Stefan von Bardeleben, Harald Becher, Jean Louis Vanoverschelde
Journal: Journal of the American College of Cardiology (2004)
Harold and Boots
Authors: Raymond Downing
Journal: JAMA (1983)

It was never entirely clear what Harold's chief complaint was. He fit fairly well in the disabled—from-his-nerves-and-back category, but when he came for a visit, I wasn't sure exactly why he was there, or what he wanted. His chief complaint seemed to be to complain. He would sit with his hands on his knees, head downcast, and speak slowly of his pain and his temper. There would be a pause, and I would make a suggestion or concluding remark, but Harold was never quite finished. He seemed to not want to be there, yet was never quite ready to leave. Earlier I shared with him the wisdom of the paindepression-pain cycle. He obliged me by attending a few counseling sessions and taking some antidepressants, neither of which affected him. He similarly eluded my attempts to nail down the exact organic nature of his problem: he either didn't go for referral
Merit Awards for Family Doctors
Authors: F. E. Graham-Bonnalie
Journal: BMJ (1966)

What I would suggest would be: (1) a standard capitatien fee (or remuneration) at entry and for the first five years (the " basic " fee).(2) A 10%/ increase after five years of service.(3) A further 10% (of the basic) increase each five years thereafter, so that after 25 years' service the general practitioner was on a maximum of 150% of the basic rate.This I feel would be the fairest way of arranging things all round.It would at least, to a certain extent, look after the general practitioner who was beginning to "feel his years," and also one living in an area where the population was tending to diminish.-Iam, etc.,
Treatment of Pseudo-Membranous Laryngitis or Croup.
Authors: O. B. Ormsby
Journal: JAMA (1889)

<h3>Dear Sir:</h3> —Some time in 1887 my attention was called to the fact that some pepsins (notably the vegetable product styled "papayotin" by Parke, Davis &amp; Co., and "papoid" by Johnson &amp; Johnson), will digest diphtheritic membranes; it will digest those that are true false-membranes and not infiltrations of the mucous membrane. Acting on this hint I have applied the same treatment to membranes within the larynx, by making a solution ([unk]j to f[unk]j water) and using it<i>very frequently</i>as a spray by means of the hand-ball apparatus. Where the child resists, as is common, I sometimes use an oval speculum. Of course this does not supersede other treatment. I have not had an opportunity to use this often enough to generalize, but I have succeeded in saving every case of croup I have treated since commencing to use it; and I verily believe that, where it is used