The Myriad Uses of Botulinum Toxin
Authors: Seth L. Pullman
Journal: Annals of Internal Medicine (2005)

Editorials6 December 2005The Myriad Uses of Botulinum ToxinSeth L. Pullman, MDSeth L. Pullman, MDFrom Columbia University Medical Center, New York, NY 10032.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-143-11-200512060-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Botulinum toxin (BTx) is an important therapeutic agent with widespread applications in neurologic and non-neurologic disease. One of the most potent neurotoxins known, BTx derives its name from the Latin word for sausage, botulus—referring to poisoning from badly prepared meat in the early 19th century. The toxin is a 150-kDa protein produced by Clostridium botulinum and composed of a heavy and light chain linked by a disulfide bond. When activated, the toxin targets peripheral cholinergic systems and prevents the release of acetylcholine. 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Wong Metrics Cited ByComparison Between Steroid and 2 Different Sites of Botulinum Toxin Injection in the Treatment of Lateral Epicondylalgia: A Randomized, Double-Blind, Active Drug-Controlled Pilot StudyBotulinum toxin type A in the healing of chronic lesion following bilateral spasticity of gluteus muscleComparison Between Botulinum Toxin and Corticosteroid Injection in the Treatment of Acute and Subacute Tennis ElbowCurrent World Literature 6 December 2005Volume 143, Issue 11Page: 838-839KeywordsAnalgesicsBotulinum toxinCholinergicsDystoniaElectromyographyMusclesPostural controlProteinsSurgeryToxins ePublished: 6 December 2005 Issue Published: 6 December 2005 CopyrightCopyright © 2005 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...