tbuckley/cabot-search huggingface dataset:
Adjuvant Radiotherapy and Chemotherapy for Pancreatic Carcinoma: The Mayo Clinic Experience (1975-2005)
Authors: Michele M. Corsini, Robert C. Miller, Michael G. Haddock, John H. Donohue, Michael B. Farnell, David M. Nagorney, Aminah Jatoi, Robert R. McWilliams, George P. Kim, Sumita Bhatia, Matthew J. Iott, Leonard L. Gunderson
Journal: Journal of Clinical Oncology (2008)

To determine prognostic factors and impact of adjuvant chemotherapy (CT) and radiotherapy (RT) on overall survival (OS) after resection of pancreatic adenocarcinoma.We performed a retrospective review 472 consecutive patients who underwent complete resection with negative margins (R0) for invasive carcinoma (T1-3N0-1M0) of the pancreas between 1975 and 2005 at the Mayo Clinic in Rochester, MN. Exclusion criteria included metastatic or unresectable disease at surgery, positive surgical margins, and indolent tumor types (islet cell tumors and mucinous cystadenocarcinoma). Median RT dose was 50.4 Gy in 28 fractions; 98% of RT patients also received concurrent fluorouracil-based CT.Six patients died within 30 days of surgery. For the 466 surviving patients, median follow-up was 32.4 months; median OS was 21.6 months. Median OS after adjuvant CT-RT was 25.2 versus 19.2 months after no adjuvant therapy (P = .001). Two-year OS was 50% versus 39%, and 5-year OS was 28% versus 17%. Adverse prognostic factors identified by univariate and multivariate analysis included positive lymph nodes (risk ratio [RR] = 1.3; P < .001), high histologic grade (RR = 1.2; P < .001), and no adjuvant therapy (RR = 1.3; P < .001). Tumor extension beyond the pancreas was an adverse prognostic factor by univariate analysis alone (P = .03). Patients receiving adjuvant therapy had more adverse prognostic factors than those not receiving adjuvant therapy (P = .001).This study represents one of the largest, single-institution, retrospective reviews of adjuvant therapy in patients after R0 resection of carcinoma of the pancreas. Overall survival was better in patients who received adjuvant CT-RT.
Free speech and professional duty: why I couldn't fight tabloid rumours
Authors: G. Needham
Journal: BMJ (2011)

I was facilitating on a residential course when I opened the email that starts this story. It was from a colleague and contained material from a post on an open forum of a professional website. The words were shocking, my colleague was concerned, and there was an indication that the poster was a doctor in training on my patch. The post contained violent intent and foul language directed against a high profile medical colleague. It was material that was difficult to overlook because the views expressed and the language used would surely alarm the public. The doctor’s likely name was evident from the post. It seemed correct, instinctively—and with hindsight it still seems correct—to forward the email to one of my team for further exploration. I would be out of the office for a while, and this extract was sufficiently disturbing that the writer surely needed help. It didn’t take long to find that the poster was indeed in one of our programmes, and this doctor acknowledged authorship. …
Reimbursement for Diabetes Self-Care Training: The North Carolina experience
Authors: William W Fore
Journal: Diabetes Care (1994)

The Diabetes Control and Complications Trial (DCCT) results prove that in insulin-dependent diabetes mellitus (IDDM), the better the level of glucose control, the lower the prevalence of complications. The team approach to help these patients is revalidated. Reimbursement for these required services has improved, but varies widely from state to state. All parties involved face the problems of translating the results to a larger diabetic population and of confronting the very real issue of how the services required to care for the disease can be made affordable and available to this patient population. These problems are very similar to those presented by the publication of standards for patient education in 1980 and its revision in 1983 (1).
Postpartum Blood Requirements and Autologous Donation
Authors: Stefan Semchyshyn
Journal: JAMA (1988)

<h3>To the Editor.—</h3> I read with interest the comments by Dr Simon<sup>1</sup>regarding postpartum blood requirements and autologous donation programs. While it is true that expense and logistic considerations are important, Dr Simon further notes that only a few of the autologous donors needed blood. In my experience, most directed blood donations are not needed by those for whom they were donated. Autologous donation programs and directed blood donation programs would help increase blood availability and alleviate the severe shortages experienced today. Also, because clean "altruistic volunteer donors" are becoming less common and the fear of contracting a deadly disease (hepatitis and acquired immunodeficiency syndrome) is real, such programs may bring the additional benefit of alleviating fears. Obstetricians and gynecologists are in an excellent position to encourage such practices because of the long-term, ongoing relationship that we enjoy with our patients and the predictability of the time and need
Improving Patient Care
Authors: Harold C. Sox
Journal: Annals of Internal Medicine (2003)

Editorials17 June 2003Improving Patient CareHarold C. Sox, MD, EditorHarold C. Sox, MD, EditorSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-138-12-200306170-00012 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail This issue marks the debut of Improving Patient Care, a new Annals section that will feature articles about quality improvement and patient safety. The new section will be about the organization of practice rather than the clinical content of care. To understand this distinction, consider Runciman and colleagues' paper in this issue, Error, Blame, and the Law in Health CareAn Antipodean Perspective (1). The subject is the characteristics of health care that cause, or contribute to, errors. Most errors do not involve moral culpability. Instead, they are the consequence of systems whose designers were not fixated on reducing errors. Rather ...Reference1. Runciman WB, Merry AF, Tito F. Error, blame, and the law in health carean Antipodean perspective. Ann Intern Med. 2003;138:974-9. LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Corresponding Author: Customer Service, American College of Physicians, 190 N. Independence Mall West, Philadelphia, PA 19106. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoPatient Safety and the Reliability of Health Care Systems Paul Barach and Donald M. Berwick Error, Blame, and the Law in Health Care—An Antipodean Perspective William B. Runciman , Alan F. Merry , and Fiona Tito Metrics Cited byLimitations of Medical Research and Evidence at the Patient-Clinician Encounter ScaleComputer protocols: how to implementImproving Patient Care Can Set Your Brain on FireSankey V. Williams, MDAnnals 2004–2005: A Peek Back and a Look ForwardThe EditorsDoctors’ responses to medical errorsStarting a Conversation about the Future of Internal MedicineThe Editors 17 June 2003Volume 138, Issue 12Page: 996KeywordsHealth careHealth maintenance organizationsHealth services researchHeartPatient advocacyPatientsPrevention, policy, and public healthQuality improvementResearch quality assessmentSafety ePublished: 17 June 2003 Issue Published: 17 June 2003 Copyright & PermissionsCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
The Hippocratic Myth: Why Doctors Are Under Pressure to Ration Care, Practice Politics, and Compromise Their Promise to Heal
Authors: Samuel Y. Sessions
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ein psychoreaktives Zustandsbild in daseinsanalytischer Interpretation
Authors: N. Schneemann
Journal: Psychotherapy and Psychosomatics (1969)

Research Articles| February 12 2010 Ein psychoreaktives Zustandsbild in daseinsanalytischer Interpretation Subject Area: Psychiatry and Psychology N. Schneemann N. Schneemann Augsburg Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1969) 17 (3-4): 257–280. https://doi.org/10.1159/000286043 Article history Published Online: February 12 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation N. Schneemann; Ein psychoreaktives Zustandsbild in daseinsanalytischer Interpretation. Psychother Psychosom 31 December 1969; 17 (3-4): 257–280. https://doi.org/10.1159/000286043 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1969Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Mating systems and fluctuating asymmetry: Firm foundations?
Authors: Innes C. Cuthill, Alasdair I. Houston
Journal: Behavioral and Brain Sciences (2000)

Gangestad &amp; Simpson review sexual selection theory and discuss their work on fluctuating asymmetry and mate preference in humans. We question some aspects of their account and mention problems with the data. We also suggest that more theoretical work on complex but realistic mating systems is required.
Bioengineered cardiac patch constructed from multilayered mesenchymal stem cells for myocardial repair
Authors: Hao-Ji Wei, Chun-Hung Chen, Wen-Yu Lee, Iwen Chiu, Shiaw-Min Hwang, Wei-Wen Lin, Chieh-Cheng Huang, Yi-Chun Yeh, Yen Chang, Hsing-Wen Sung
Journal: Biomaterials (2008)
The Acquired Immunodeficiency Syndrome in Persons with Hemophilia
Authors: PETER H. LEVINE
Journal: Annals of Internal Medicine (1985)

The widespread use of coagulation factor concentrates prepared from the blood of numerous donors has doubled the life expectancy of persons with hemophilia, but parenteral exposure to alloantigens and infectious agents is not free of risk. The prevalence of the acquired immunodeficiency syndrome (AIDS) now approaches 1% in patients with hemophilia, and laboratory evidence of abnormal immunoregulation is found in at least 50% of treated patients with severe hemophilia. The immune defect is multifactorial. The attack rate of AIDS among patients with severe hemophilia appears to have reached a peak; further evidence suggests that only a minority of those infected with human T-lymphotropic virus type III will develop AIDS. The advent of improved donor screening methods and the application of heat treatment of coagulation factor concentrates should further reduce the risk of AIDS in persons with hemophilia.
Magnetic-field-induced DNA strand breaks in brain cells of the rat.
Authors: Henry Lai, Narendra P Singh
Journal: Environmental Health Perspectives (2004)

In previous research, we found that rats acutely (2 hr) exposed to a 60-Hz sinusoidal magnetic field at intensities of 0.1-0.5 millitesla (mT) showed increases in DNA single- and double-strand breaks in their brain cells. Further research showed that these effects could be blocked by pretreating the rats with the free radical scavengers melatonin and N-tert-butyl-alpha-phenylnitrone, suggesting the involvement of free radicals. In the present study, effects of magnetic field exposure on brain cell DNA in the rat were further investigated. Exposure to a 60-Hz magnetic field at 0.01 mT for 24 hr caused a significant increase in DNA single- and double-strand breaks. Prolonging the exposure to 48 hr caused a larger increase. This indicates that the effect is cumulative. In addition, treatment with Trolox (a vitamin E analog) or 7-nitroindazole (a nitric oxide synthase inhibitor) blocked magnetic-field-induced DNA strand breaks. These data further support a role of free radicals on the effects of magnetic fields. Treatment with the iron chelator deferiprone also blocked the effects of magnetic fields on brain cell DNA, suggesting the involvement of iron. Acute magnetic field exposure increased apoptosis and necrosis of brain cells in the rat. We hypothesize that exposure to a 60-Hz magnetic field initiates an iron-mediated process (e.g., the Fenton reaction) that increases free radical formation in brain cells, leading to DNA strand breaks and cell death. This hypothesis could have an important implication for the possible health effects associated with exposure to extremely low-frequency magnetic fields in the public and occupational environments.
Website of the week: Booking time: finding locums and devising rotas
Authors: D. Carnall
Journal: BMJ (2002)

For the last couple of years internet gurus have been predicting the rise in the application service provider (ASP) market. One software vendor, Microsoft, has bet the future of its business on its .NET business model (www.microsoft.com/net/). But the big software companies will not necessarily have it all their own way. One of the features of the ASP model is the relative ease with which organisations can shift providers, which means that small niche application developers who understand their business well have …
Acute massive necrosis of the liver induced by antibody/complement, not by T-cells
Authors: Kunio Okuda
Journal: Hepatology (1989)

Acute fulminant hepatic injury was induced in rats within 1 hour after a single intravenous injection of a monoclonal antibody to rat liver cell membrane (MoAb). The liver injury induced by MoAb was characterized by multiple focal hepa-tocellular necrosis which was associated with marked increase in serum AST, ALT, and LDH activity. Inflammatory cell infiltration was not observed in the necrotic foci. Immunohistological study showed marked deposition of complement in the necrotic area, suggesting that the membrane-damaging action of the complement system activated by the antigen-antibody reaction between the hepatocyte membrane and MoAb may play an important role in the pathogenesis of MoAb-in-duced hepatic injury in rats.
Acute Renal Failure and Maneb (Manganous Ethylenebis[dithiocarbamate]) Exposure
Authors: Akio Koizumi
Journal: JAMA (1979)

A 62-year-old man spread maneb on about 200 sq m of garden and subsequently was taken to the emergency clinic with complaints of oliguria, diarrhea, and hoarseness. Based on the clinicobiochemical data, he was found to have acute renal failure; the serum levels of BUN, creatinine, and potassium were 144.3 mg/dL, 14 mg/dL, and 5.8 mEq/L, respectively. The ST segment depression in V<sub>4-6</sub>, reciprocal ST segment elevation in V<sub>1-3</sub>, and inverted T waves in V<sub>5</sub>and V<sub>6</sub>were recorded on ECGs. Both the renal failure and the ECG abnormalities disappeared after hemodialysis. The possibility exists that the maneb caused the acute renal failure. (<i>JAMA</i>242:2583-2585, 1979)
Berman’s Pediatric Decision Making
Authors: Rizwana Popatia
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mechanism for calcium urolithiasis among patients with hyperuricosuria: supersaturation of urine with respect to monosodium urate.
Authors: C Y Pak, O Waters, L Arnold, K Holt, C Cox, D Barilla
Journal: Journal of Clinical Investigation (1977)

Since monosodium urate (NaU) may play an important etiologic role in the formation of renal stones containing Ca in patients with hyperuricosuria, the current studies were undertaken to define some of the physiocochemical factors which determine the formation of NaU. In solutions containing Na, uric acid was rapidly transformed to NaU at pH greater than 6. The results indicated that NaU, and not uric acid, was the stable phase above this pH. A reliable and simple method for the calculation of the state of saturation of urine with respect to NaU was developed from the ratio of concentration products of Na and total dissolved urate (Upi) in the ambient fluid before and after incubation of urine with synthetic NaU. The concentration product ratio closely approximated the ratio of activity products of Na+ and acid urate ion. In contrast, the relative saturation ratio, or the ratio of activity product of original sample and the thermodynamic solubility product of NaU, often differed from the activity product ratio in the individual urine samples. With the concentration product rate, it was found in 45 urine samples that a critical determinant for the supersaturated state with respect to NaU was the high concentration of UT. At UT greater than 300 mg/liter, urine samples were invariably supersaturated with respect to NaU. These results suggest that the nidus of NaU could potentially form in the urine of patients with hyperuricosuria and Ca stones.
Hypercholesterolemia in postmenopausal women. Metabolic defects and response to low-dose lovastatin
Authors: M. Arca
Journal: JAMA (1994)

<h3>Objective.</h3> —To determine the metabolic mechanisms underlying hypercholesterolemia in postmenopausal women and to determine whether a low dose of lovastatin will correct this abnormality. <h3>Design.</h3> —In the first part of the study, turnover rates of autologous low-density lipoprotein (LDL) were measured in hypercholesterolemic and control women. In the second part, hypercholesterolemic women participated in a placebo-controlled, randomized, double-blind study using lovastatin as the therapeutic agent. <h3>Setting.</h3> —The General Clinical Research Center of the University of Texas Southwestern Medical Center, Dallas, utilizing inpatient and outpatient facilities, and the Veterans Affairs Medical Center, Dallas, Tex. <h3>Patients.</h3> —For the LDL turnover study, 26 postmenopausal women with moderate hypercholesterolemia (mean±SD LDL cholesterol, 4.78±0.59 mmol/L [185 ±23 mg/dL]) and 13 postmenopausal women with normal levels of plasma lipids and lipoproteins (mean±SD LDL cholesterol, 3.31 ±0.39 mmol/L [128±15 mg/dL]) were studied. Sixteen postmenopausal women participated in the drug study. <h3>Interventions.</h3> —In the drug study, patients received blindly both lovastatin (10 mg/d) and placebo. <h3>Main Outcome Measures.</h3> —In the first study, kinetic parameters of LDL metabolism; in the second study, response in lipids and lipoproteins to lovastatin therapy. <h3>Results.</h3> —In the LDL turnover study, mean (±SD) input (production) rates for LDL apolipoprotein B (apo B) were similar for hypercholesterolemic women and control women (12.4 [±3.2] mg/kg per day and 11.1 [±2.2] mg/kg per day, respectively). In contrast, mean (±SD) fractional catabolic rates for LDL apo B in hypercholesterolemic women (0.29 [±0.04] pools per day) were significantly lower than those in normolipidemic women (0.35 [±0.03] pools per day). In the drug trial, lovastatin therapy reduced mean (±SD) total cholesterol and LDL cholesterol from 7.03 (±1.16) mmol/L (272 [±45] mg/dL) and 4.42 (±0.80) mmol/L (171 [±31] mg/dL, respectively, to 5.70 (±1.03) mmol/L (221 [±40] mg/dL) and 3.46 (±0.85) mmol/L (134 [±33] mg/dL). <h3>Conclusions.</h3> —The turnover data suggest that hypercholesterolemia in postmenopausal women is primarily attributable to a reduced activity of LDL receptors. In accord, the hypercholesterolemia in these women was effectively lowered by low doses of lovastatin. Thus, a low dose of lovastatin appears highly effective for treatment of moderate hypercholesterolemia in most postmenopausal women, presumably because it reverses the reduction in LDL receptor activity associated with menopause. (<i>JAMA</i>. 1994;271:453-459)