tbuckley/cabot-search huggingface dataset:
A Racial Difference in the Incidence of Lactase Deficiency (A Hereditary Tummy-Ache?).
Authors: Theodore M. Bayless
Journal: Annals of Internal Medicine (1967)

s1 May 1967A Racial Difference in the Incidence of Lactase Deficiency (A Hereditary Tummy-Ache?).Theodore M. Bayless, M.D., Shi-Shung Huang, M.D., Norton S. Rosensweig, M.D.Theodore M. Bayless, M.D.Search for more papers by this author, Shi-Shung Huang, M.D.Search for more papers by this author, Norton S. Rosensweig, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-5-1030_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWhen some adults ingest more than one or two glasses of milk, they develop abdominal cramps and diarrhea. Their symptoms can be reproduced with oral lactose, the milk sugar, and the enzyme that digests lactose is deficient in their jejunal mucosa.The prevalence of this enzyme deficiency in the general population is not known. The etiologic possibilities include (1) adaptation to decreased milk intake, (2) damage to the intestine, and (3) a genetically determined trait.In an incidence survey of 40 consecutive healthy adult males (20 Negroes and 20 whites), 19 of the 20 Negro and 2 of the 20... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Theodore M. Bayless, M.D.; Shi-Shung Huang, M.D.; Norton S. Rosensweig, M.D.Affiliations: Baltimore, Maryland PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1967Volume 66, Issue 5Page: 1030-1031KeywordsDiarrheaEnzymesHealth surveysLactoseMilkMucous membranes ePublished: 1 December 2008 Issue Published: 1 May 1967 PDF downloadLoading ...
The erythropoietin receptor is a downstream effector of Klotho-induced cytoprotection
Authors: Ming-Chang Hu, Mingjun Shi, Han J. Cho, Jianning Zhang, Alevtina Pavlenco, Shuzhen Liu, Sachdev Sidhu, Lily J.-S. Huang, Orson W. Moe
Journal: Kidney International (2013)
Phase I/II study of Resiquimod as an immunologic adjuvant for NY-ESO-1 protein vaccination in patients with melanoma
Authors: Rachel L Sabado, Anna Pavlick, Sacha Gnjatic, Crystal Cruz, Isabelita Vengco, Farah Hasan, Farbod Darvishian, Luis Chiriboga, Rose Marie Holman, Juliet Escalon, Caroline Muren, Crystal Escano, Ethel Yepes, Dunbar Sharpe, Sylvia Adams, Patrick Ott, Achim Jungbluth, Linda Pan, Ralph Venhaus, Nina Bhardwaj
Journal: Journal for ImmunoTherapy of Cancer (2013)

Meeting abstracts The TLR 7/8 agonist, Resiquimod has been shown to induce local activation of immune cells, production of cytokines, and antigen-presentation by dendritic cells, features desirable for cancer vaccine adjuvants. In this study, we evaluated the safety and immunogenicity of
Pancytopenia as a clonal disorder of a multipotent hematopoietic stem cell.
Authors: J L Abkowitz, P J Fialkow, D J Niebrugge, W H Raskind, J W Adamson
Journal: Journal of Clinical Investigation (1984)

Hematopoiesis was investigated in a 14-yr-old girl who had a 2-yr history of stable asymptomatic pancytopenia and who was also heterozygous at the structural locus for glucose-6-phosphate dehydrogenase (G-6-PD). There was no morphologic or cytogenetic evidence for preleukemia and no suggestion of Fanconi anemia. In the skin and sheep erythrocytes-rosetted T lymphocytes, the ratio of G-6-PD A/B activities was 1:1. However, only type B activity was found in peripheral blood erythrocytes, granulocytes, and platelets. Most erythroid bursts and all granulocyte/macrophage colonies formed in methylcellulose culture were derived from the abnormal clone. These findings demonstrate that (a) some cases of pancytopenia are stem cell diseases that apparently develop clonally; (b) circulating differentiated cells originate from this clone; (c) despite a hypoproliferative anemia, the in vivo expression of presumably normal (nonclonal) progenitors is suppressed. In this patient, the relationship between clonal dominance and possible malignancy may be assessed prospectively.
The Corpsman as Teacher
Authors: Tom M. Johnson
Journal: JAMA (1970)

<h3>To the Editor.—</h3> In the recent literature regarding the use of ex-military medical corpsmen as paramedical personnel to help relieve the civilian physician shortage,<sup>1,2</sup>one area of possible utility has been neglected: that of the medical corpsman as a medical student teacher. In a program initiated recently at Michigan State University College of Human Medicine, East Lansing, a retired naval medical corpsman with 30 years' service and independent duty experience has been appointed and trained to teach beginning procedural physical diagnosis to the first-year and second-year students. A continuing training program for this paramedical teacher is being conducted by members of the medical staff. With his previous experience and training, a high level of performance was easily accomplished. He has been well accepted by the students in his initial teaching assignments. His experience on independent medical duty seems important for qualifying him in his role as a teacher in
Abstract 2182: Novel ATP-competitive protein kinase D inhibitors: in vitro characterization and SAR analysis.
Authors: Manuj Tandon, James Johnson, Elisa Farber, Evan Carder, Peter Wipf, Qiming J. Wang
Journal: Cancer Research (2013)

Abstract Protein Kinase Ds (PKDs) are serine/threonine kinases targeted by the second messenger diacylglycerol. The three isoforms of PKD (PKD1, PKD2, and PKD3) have emerged as key mediators in diverse cellular processes pertaining to cancer development including proliferation, apoptosis, migration/invasion and angiogenesis. Potent and selective PKD inhibitors are powerful tools in dissecting PKD-mediated cellular pathways and promising leads for developing effective anticancer agents. From targeted kinase inhibitor library screens we identified three highly potent novel ATP-competitive PKD inhibitors, IKK 16, 1-naphthyl PP1 and SD 208 with in vitro PKD inhibitory activity in low nanomolar range. All inhibitors except IKK 16 showed high selectivity for PKD relative to the related kinase family PKC and CAMK. When tested in LNCaP prostate cancer cells the compounds inhibited phorbol ester-induced PKD1 activation in a concentration dependent manner. SD 208 was found to be most specific for PKD and it did not affect the PKC mediated trans-phosphorylation of PKD1 at S744/748. Importantly, 1-naphthyl PP1 and SD 208 potently blocked prostate cancer cell proliferation and concentration-dependently induced cell death. SAR analysis of SD 208 and 1-naphthyl PP1 led to identification of key structural elements that are important for PKD inhibitory activity. In summary, we have identified and evaluated a panel of structurally divergent novel ATP-competitive PKD small molecule inhibitors with potent PKD inhibitory activities that could be further developed as potential antitumor agents in prostate cancer. Citation Format: Manuj Tandon, James Johnson, Elisa Farber, Evan Carder, Peter Wipf, Qiming J. Wang. Novel ATP-competitive protein kinase D inhibitors: in vitro characterization and SAR analysis. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2182. doi:10.1158/1538-7445.AM2013-2182
Cimetidine in treatment of reflux oesophagitis with peptic stricture.
Authors: R Ferguson, M W Dronfield, M Atkinson
Journal: BMJ (1979)

Twenty patients with reflux oesophagitis causing a tight peptic oesophageal stricture entered a randomised double-blind crossover trial in which they received cimetidine, 1.6 g daily, and matching placebo each for six months. The gross endoscopic appearances of oesophagitis, though not the grades of histopathological changes, showed significant improvement during treatment with cimetidine. The need for dilatation of the strictures, however, was not reduced.
The Misrepresentation of Arthritis Drugs and Devices in the United States
Authors: Oliver Field
Journal: JAMA (1961)

The Walrad report, published by the Arthritis and Rheumatism Foundation, is a curiously interesting compilation of facts and figures; a review of the development of statutory protection in the form of federal and state laws; and a primer on the significance of the social legislation and the enforcement procedures thereof, as applied to the problem of misrepresentation and fraud in the field of arthritis and rheumatism remedies. In this sense, the title is too narrow, because the thesis applies to the many other categories of disease and the methods and tricks used by quacks and nostrum peddlers for their profit at the expense of the sick. The book contains detailed information on many of the techniques of dealers in pseudomedicine in the arthritis field. The unfortunate thing is that the report will have the interest of only a limited number of people. In its rational approach to the problem of
High incidence of trisomies 1q, 9q, and 11q in multiple myeloma: results from a comprehensive molecular cytogenetic analysis
Authors: P Liebisch, C Wendl, A Wellmann, A Kröber, G Schilling, H Goldschmidt, H Einsele, C Straka, M Bentz, S Stilgenbauer, H Döhner
Journal: Leukemia (2003)
FDA Approval of Cardiac Implantable Electronic Devices via Original and Supplement Premarket Approval Pathways, 1979-2012
Authors: Benjamin N. Rome, Daniel B. Kramer, Aaron S. Kesselheim
Journal: JAMA (2014)

<h3>Importance</h3> The US Food and Drug Administration (FDA) evaluates high-risk medical devices such as cardiac implantable electronic devices (CIEDs), including pacemakers, implantable cardioverter-defibrillators, and cardiac resynchronization therapy devices, via the premarket approval (PMA) process, during which manufacturers submit clinical data demonstrating safety and effectiveness. Subsequent changes to approved high-risk devices are implemented via "supplements," which may not require additional clinical testing. <h3>Objective</h3> To characterize the prevalence and characteristics of changes to CIEDs made through the PMA supplement process. <h3>Design</h3> Using the FDA's PMA database, we reviewed all CIEDs approved as original PMAs or supplements from 1979 through 2012. For each supplement, we collected the date approved, type of supplement (panel-track, 180-day, real-time, special, and 30-day notice), and the nature of the changes. We calculated the number of supplements approved per PMA and analyzed trends relating to different supplement regulatory categories over time. For supplements approved via the 180-day regulatory pathway, which often involve significant design changes, from 2010-2012, we identified how often additional clinical data were collected. <h3>Results</h3> From 1979-2012, the FDA approved 77 original and 5829 supplement PMA applications for CIEDs, with a median of 50 supplements per original PMA (interquartile range [IQR], 23-87). Excluding manufacturing changes that do not alter device design, the number of supplements approved each year was stable around a mean (SD) of 2.6 (0.9) supplements per PMA per year. Premarket approvals remained active via successive supplements over a median period of 15 years (IQR, 8-20), and 79% of the 77 original PMAs approved during our study period were the subject of at least 1 supplement in 2012. Thirty-seven percent of approved supplements involved a change to the device's design. Among 180-day supplements approved from 2010-2012, 23% (15/64) included new clinical data to support safety and effectiveness. <h3>Conclusions and Relevance</h3> Many CIED models currently used by clinicians were approved via the PMA supplement process, not as original PMAs. Most new device models are deemed safe and effective without requiring new clinical data, reinforcing the importance of rigorous postapproval surveillance of these devices.
Long-term Neuroendocrine Effects of Childhood Maltreatment
Authors: Rickard L. Sjöberg
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Does femoral venous pressure measurement correlate well with intrabladder pressure measurement? A multicenter observational trial
Authors: Bart L. De Keulenaer, Adrian Regli, Wojciech Dabrowski, Vaxtang Kaloiani, Zsolt Bodnar, Javier Izura Cea, A. Andrey Litvin, Wendy A. Davis, Anne-Marie Palermo, Jan J. De Waele, Manu L. L. N. G. Malbrain
Journal: Intensive Care Medicine (2011)
Book Review Hematology: Basic principles and practice Edited by Ronald Hoffman, Edward J. Benz, Jr., Sanford J. Shattil, Bruce Furie, and Harvey J. Cohen. 1919 pp., illustrated. New York, Churchill Livingstone, 1991. $120.95. ISBN 0–443–08643–5 .
Authors: Marc A. Shuman, Robert L. Cohen, Peter T. Curtin
Journal: New England Journal of Medicine (1992)
Syncope, driving recommendations, and clinical reality: survey of patients
Authors: R. Maas
Journal: BMJ (2003)

Syncope is a common clinical condition, 1 which for obvious reasons constitutes a very drastic form of driving impairment.The legislative and expert panels in most countries have therefore issued laws or guidelines regarding driving and syncope. [2]3][4] So far, however, little is known about the impact of driving recommendations on the behaviour of patients or the incidence of traffic crashes.
Three-dimensional echocardiography: In vivo validation for right ventricular free wall mass as an index of hypertrophy
Authors: Leng Jiang, Jose Antonio Vazquez de Prada, Mark D. Handschumacher, J.Luis Guererro, Gus J. Vlahakes, Mary Etta King, Arthur E. Weyman, Robert A. Levine
Journal: Journal of the American College of Cardiology (1994)
RESTING GLOBAL AND REGIONAL LEFT VENTRICULAR CONTRACTILITY IN PATIENTS WITH HEART FAILURE AND NORMAL EJECTION FRACTION - INSIGHTS FROM SPECKLE-TRACKING ECHOCARDIOGRAPHY
Authors: Gabriel W.K. Yip, Qing Zhang, Jun-Min Xie, Yu-Jia Liang, Ying-Mei Liu, Bryan P. Yan, Yat-Yin Lam, Cheuk-Man Yu
Journal: Journal of the American College of Cardiology (2010)
A rare cause of gastrointestinal bleeding in a patient with hyper-IgE syndrome
Authors: M Gotzberger
Journal: Gut (2004)

Background: Salmonella enterica serovar typhimurium (S typhimurium) causes invasive gastroenteritis in humans, a disease involving significant penetration of the intestinal mucosa.However, few studies have been undertaken to investigate this interaction directly using differentiated human gut tissue.Aims: To investigate the early interactions of an enteropathogenic strain of S typhimurium with human intestinal mucosa using human intestinal in vitro organ culture (IVOC).Methods: Wild-type and mutant derivatives of S typhimurium TML were used to compare interactions with cultured human epithelial cells, bovine ligated loops, and human intestinal IVOC.Results: S typhimurium TML was shown to attach to cultured Caco-2 brush border expressing cells and cause tissue damage and fluid accumulation in a ligated bovine loop model.S typhimurium TML bound predominantly to the mucus layer of human IVOC explants during the first four hours of IVOC incubation.From four to eight hours of IVOC incubation, small but characteristic foci of attaching and invading S typhimurium TML were detected as clusters of bacteria interacting with enterocytes, although there was no evidence for large scale invasion of explant tissues.Ruffling of enterocyte membranes associated with adherent Salmonella was visualised using electron microscopy.Conclusions: Human IVOC can be used as an alternative model for monitoring the interactions between S typhimurium and human intestinal epithelium, thus potentially offering insight into the early stages of human Salmonella induced gastroenteritis.
Carbohydrate Metabolism in African Women with Twin Pregnancy
Authors: S P Moodley, I Jialal, J Moodley, R S Naicker, M Marivate
Journal: Diabetes Care (1984)

Carbohydrate metabolism was evaluated in 21 twin pregnancies and in 21 women with singleton pregnancies. The groups were matched for age, weight, parity, and period of gestation. A 100-g oral glucose tolerance test was performed on all 42 subjects. No significant differences in venous plasma glucose responses were found between singleton and twin pregnancies. The only significant difference between the insulin responses of the two groups was a lower plasma insulin concentration at 60 min in the twin group (P less than 0.03).
Captopril in congestive cardiac failure.
Authors: D. J. Webb, J. R. Cockcroft
Journal: BMJ (1989)

antibiotics in these high risk situations has re- peatedly been shown to reduce the incidence of subsequent infection.In the labour ward attention to basic principles of asepsis and surgery can easily fall.This is understandable for a variety of reasons, but none the less it remains unacceptable.Lessons which were learnt by our predecessors from maternal deaths in the preantibiotic era are often forgotten by junior doctors, to whom antibiotics can become the panacea of all ills.By all means let us use prophylactic antibiotics for caesarean section in patients at high risk, but at the same time let us audit the figures for our own units and make sure that they are not being used to compensate for lack of proper attention to basic obstetric, aseptic, and surgical techniques.These result in savings that cost nothing.
81. A Retrovirus Vector Screen for the Identification of Novel Chromatin Insulators and Enhancers
Authors: Amy C. Groth, George Stamatoyannopoulos, David W. Emery
Journal: Molecular Therapy (2005)

The application of integrating vectors for gene therapy can be limited by inadequate levels of vector expression and high rates of vector silencing often associated with chromosomal position effects. Such limitations can be overcome in part through the use of cis-acting regulatory elements such as enhancers and chromatin insulators. However, only a handful of enhancers and only one chromatin insulator have been validated for use in recombinant virus vectors to date, and these may not be suitable or fully effective in all settings. In order to expand the available repertoire of such elements, we performed a functional screen to identify new genetic elements that improve the consistency and level of expression of oncoretrovirus vectors. Since chromatin insulators typically work in pairs, we generated a library of oncoretrovirus vectors containing fragments of the human genome in the double-copy position of the 3' LTR, from which they are copied into the 5' LTR during virus replication. This vector library was then subjected to multiple rounds of transduction at low multiplicities of infection between ecotropic and amphotropic packaging lines. At each step, we sorted the 2–10% of transduced cells expressing the highest amount of the LTR-GFP vector cassette, and used these to produce virus for the next round. This was done in part based on pilot studies indicating that flanking this vector with the prototypic chromatin insulator cHS4 increased the fraction of cells expressing the highest levels of GFP (presumably by reducing the frequency of silencing position effects). The candidates generated from this scheme are likely to include repressor-blocking chromatin insulators, enhancers, strong promoters and/or RNA stability elements. After three rounds of enrichment, 96 clones from 6 independent pools were analyzed. Of these, twenty unique sequences were identified, indicating that the screen had significantly enriched for a subset of clones originally present in the library. The average length of these sequences was 772 bp, and the average GC content was 50.1%. These candidates were mapped to the human genome by BLAT. Eleven were found to be intergenic, seven were in introns, and two spanned an exon and extended into introns on either side. The average distance to the nearest transcription start site was 64 kb and to the nearest transcription stop site was 71 kb. The candidates were analyzed by the motif-finding program MEME, and several significant and novel motifs were found that were also present in the prototypic cHS4 chromatin insulator. These candidates are currently being tested in independent assays for chromatin insulator activity, enhancer activity and DNaseI hypersensitivity. Any insulators or enhancers identified by this screen are candidates for use in oncoretrovirus-based gene therapy vectors, since their compatibility with virus production has already been established.
Failure to Report Financial Disclosure Information
Authors: Grace Lu-Yao, Peter Albertsen, Weichung Shih, Siu Long Yao
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Noninvasive in vivo quantitative assessment of fat content in human liver
Authors: Claudio Ricci, Renata Longo, Eugenio Gioulis, Marco Bosco, Piero Pollesello, Flora Masutti, Lory S. Crocè, Sergio Paoletti, Benedetto de Bernard, Claudio Tiribelli, Ludovico Dalla Palma
Journal: Journal of Hepatology (1997)