tbuckley/cabot-search huggingface dataset:
Retention of Radioiron in the Lungs of a Woman with Idiopathic Pulmonary Hemosiderosis
Authors: RICHARD L. DEGOWIN
Journal: Annals of Internal Medicine (1968)

This paper presents studies of a menopausal woman with idiopathic pulmonary hemosiderosis who had only slight hemoptysis, no measurable blood loss, but a major intrapulmonary hemorrhage. Labeled hemoglobin-iron sequestered in the lung could not be readily mobilized by the body or with an iron-chelating agent in the presence of an iron-responsive hypochromic anemia. In this case, linear profile scanning proved helpful in the diagnosis of pulmonary hemorrhage. Finally, idiopathic pulmonary hemosiderosis should be considered as a cause of unexplained cough, ephemeral pulmonary infiltrates, and iron-responsive hypochromic anemia in any age patient. Diagnosis may be made by looking for hemosiderin-laden macrophages in the sputum or gastric aspirates, and by performing radioisotope studies and a lung biopsy.
Arterial oxygen saturation during upper gastrointestinal endoscopy: the effects of a midazolam/pethidine combination.
Authors: A W Murray, C G Morran, G N Kenny, J R Anderson
Journal: Gut (1990)

This study was performed to assess the severity and duration of hypoxia during and after prolonged upper gastrointestinal endoscopy. Twenty patients were studied using a non-invasive pulse oximeter. Significant reductions in oxygen saturation were noted during endoscopy and remained below the preexamination level during the one hour period after the examination. This study indicates that pulse oximetry is a useful monitor for detection of hypoxia during and after endoscopy.
Stress Fracture of the Pubic Ramus in a Swimmer
Authors: SUNG M. KIM, CHAN H. PARK, JOHN J. GARTLAND
Journal: Clinical Nuclear Medicine (1987)

Stress fracture is common in military recruits, joggers, and runners. Stress fracture in the pubic ramus is not common, and it constitutes only 1.25% of all stress fractures. A stress fracture, avulsion type of the pubis at the insertion of adductor magnus on an active swimmer is reported here.
The Doctor and Vocational Rehabilitation for Civilians in Massachusetts
Authors: Herbert A. Dallas
Journal: New England Journal of Medicine (1947)

AN OPPORTUNITY for members of the medical profession to take part in the vocational rehabilitation of handicapped civilians is presented to the private practitioner and specialist through a program administered by each state in partnership with the federal government. Recently, a pamphlet entitled The Doctor and Vocational Rehabilitation for Civilians was sent to all members of the American Medical Association, with a copy of a letter from Henry H. Kessler, M.D., consultant to the Office of Vocational Rehabilitation, Federal Security Agency, to inform every physician of the new services available for the assistance of handicapped patients. The Division of Vocational . . .
Preliminary Note on an Unclassified Type of West African Fever
Authors: S. W. Thompstone, R. A. Bennett
Journal: BMJ (1901)

Compared with the tropical malaria (where, as already re- marked, gametocytes persist a long time after the last attacks of fever) the state of things here related will assist to a high degree the success of the measures that must be taken against the spreading of the disease.Supposing that man is the onjy or principal intermediary host for the described parasites, jealously protecting him only during the periods of fever and one or two days afterwards against the bites of mosquitos, will diminish greatly the number of infected insects, and in consequence reduce the fever-rate to a minimum.With the aid of the other measures advised by the members of the
Anatomy, Descriptive and Surgical
Authors: Stanley W. Jacob
Journal: JAMA (1993)

Henry Gray was a young man when he wrote his<i>Anatomy</i>. He died in his mid-30s, within two years of authoring the book. Yet what he wrote in 1858 has outlived him by almost a century and a half and has reigned as the definitive text in the field until well into the middle of the 20th century. Even now, although dozens of anatomy books have appeared in the last few decades, most physicians would agree that<i>Gray's Anatomy</i>remains a classic in its field. It was recognized as a classic even in the first review of the original edition, which intoned, "We may say with truth, that there is not a treatise in any language in which the relations of anatomy and surgery are so clearly and fully shown." Praising the book's outstanding ability "to furnish the student and practitioner with an accurate view of the human body, and
Voluntary Death: A Comparison of Terminal Dehydration and Physician-Assisted Suicide
Authors: Franklin G. Miller
Journal: Annals of Internal Medicine (1998)

The controversial issue of legalizing physician-assisted suicide should be considered in light of legally available alternative methods of voluntary death. The increasingly polarized debate over this issue has failed to give due attention to an alternative: terminal dehydration. By voluntarily forgoing food and water, competent patients with terminal or incurable illness can escape intolerable, irremediable conditions without requiring transformation of the law and medical ethics. Terminal dehydration offers substantial advantages over physician-assisted suicide with respect to self-determination, access, professional integrity, and social implications but also has distinctive drawbacks as a humane means of voluntary death. This article analyzes clinical, ethical, and policy issues related to terminal dehydration compared with physician-assisted suicide.
Thrombocytopenia and Sulindac
Authors: GEORGE N. KARACHALIOS
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 January 1986Thrombocytopenia and SulindacGEORGE N. KARACHALIOS, M.D., JOHN G. PARIGORAKIS, M.D.GEORGE N. KARACHALIOS, M.D.Search for more papers by this author, JOHN G. PARIGORAKIS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-104-1-128_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Sulindac is a nonsteroidal anti-inflammatory and analgesic drug that is now used extensively in the treatment of various forms of rheumatic disease. Several reports of adverse reactions, such as hepatotoxicity, Stevens-Johnson syndrome, aplastic anemia, and hypersensitivity, have been noted (1, 2). We report a case in which a severe thrombocytopenic reaction was associated with the use of sulindac.A 67-year-old woman presented with a painful shoulder and right knee in March 1982. History and physical findings were consistent with osteoarthritis, and treatment was started with diclofenac sodium for 1 month without effect. On 15 May, diclofenac sodium...References1. PARKSPECTORHEADSTREAMGOLDBERG GRTM. Serious adverse reactions associated with sulindac. Arch Intern Med. 1982;142:1292-4. CrossrefMedlineGoogle Scholar2. SMITHLINDBERG FP. Life-threatening hypersensitivity to sulindac. JAMA. 1980;244:269-70. CrossrefMedlineGoogle Scholar3. ROSENBAUMO'CONNOR JM. Thrombocytopenia associated with sulindac. Arthritis Rheum. 1981;24:752-3. CrossrefMedlineGoogle Scholar4. SIMONMILLS LJ. Nonsteroidal anti-inflammatory drugs. N Engl J Med. 1980;202:1179-85. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Kalamata General Hospital Kalamata Greece PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByDiclofenac-induced thrombocytopenic purpura with renal and hepatic involvement 1 January 1986Volume 104, Issue 1Page: 128-128KeywordsAdverse reactionsAnalgesicsAplastic anemiaHypersensitivityKneesOsteoarthritisShouldersSodium Issue Published: 1 January 1986 PDF DownloadLoading ...
DIURNAL VARIATION IN THE URINARY EXCRETION OF NEUTRAL LIPID-SOLUBLE REDUCING STEROIDS IN CONGESTIVE CARDIAC FAILURE AND CIRRHOSIS OF THE LIVER WITH ASCITES 12
Authors: Ralph Goldman, Samuel H. Bassett
Journal: Journal of Clinical Investigation (1952)

Pincus and his collaborators (1-4) have demonstrated that there is a normal cycle of excretion of neutral, lipid-soluble reducing steroids which has a maximum between 7 a.m. and 11 a.m., decreases during the afternoon, and is at a minimum during the night. This corresponds to the normal excretory cycle of other urinary constituents (5-13). It has also been shown that in congestive cardiac failure (14, 15) and in cirrhosis of the liver with ascites (16) there is a reversed diurnal cycle of water and sodium excretion, with maximum values during the night in a high proportion of the individuals studied. This investi
Mycobacterial infection of a congenital bronchogenic cyst.
Authors: W C Houser, G J Dorff, D Y Rosenzweig, J W Aussem
Journal: Thorax (1980)

Bronchogenic cysts result from an abnormal budding or branching of the tracheobronchial tree.Approximately 30% of the cysts are located in the mediastinum and the remaining 70% in the lung.The cyst may be joined to the tracheobronchial tree by a fistula or by a fibrous band.Pulmonary bronchogenic cysts occur most fre- quently in the lower lobes, primarily on the right side.They are thin-walled, single or multiple, and lined with respiratory epithelium.The wall consists primarily of fibrous connective tissue and may contain mucous glands, hyaline cartilage, smooth muscle, nerve trunks, and elastic fibres.Bronchial communication with the cyst may be present.Intermittent patency of this communication allows accumulation of various combinations of air, fluid, blood, and purulent material within the cyst.Approximately 15 % of patients with bronchogenic
Liver inflammation and acute respiratory distress syndrome in a patient receiving hepatitis B vaccine: a possible relationship?
Authors: V. M. Ranieri, A. Dell’Erba, A. Gentile, F. Bruno, V. La Gioia, A. Spagnolo, R. Sacco, G. Caruso, S. Antonaci, O. Schiraldi, A. Brienza
Journal: Intensive Care Medicine (1997)
Muscular Uptake of Tc-99m Sestamibi Showing Collateral Flow in a Case of Venous Thrombosis
Authors: DAVID H. SKLAR, CAROL S. MARCUS
Journal: Clinical Nuclear Medicine (1997)

A 70-year-old man had preoperative cardiac evaluation prior to a Whipple procedure for pancreatic carcinoma. A resting Tc-99m sestamibi study showed obstruction of the left brachiocephalic vein. The radiopharmaceutical eventually reached the heart, but extraction of a portion of the Tc-99m sestamibi occurred in muscles of the left arm and chest wall, which provided indirect, static documentation of collateral flow. This observation of signal amplification may provide a new basis for performing radionuclide venography in cases of suspected deep vein thrombosis.
381 SERUM HEPATITIS B VIRUS DNA LEVEL AT ONE YEAR AFTER HEPATITIS B E ANTIGEN SEROCONVERSION PREDICTS SUBSEQUENT HEPATITIS B REACTIVATION
Authors: T.-C. Tseng, C.-J. Liu, C.-C. Wang, P.-J. Chen, M.-Y. Lai, D.-S. Chen, J.-H. Kao
Journal: Journal of Hepatology (2009)
THE INCORPORATION OF PLASMA FREE FATTY ACIDS INTO PLASMA TRIGLYCERIDES IN MAN*
Authors: S. J. Friedberg, R. F. Klein, D. L. Trout, M. D. Bogdonoff, E. H. Estes
Journal: Journal of Clinical Investigation (1961)

Plasma triglycerides (neutral fat) may be di- vided into 1) that portion which is present during the fasting state and 2) that which, after ingestion of fat, is added to and temporarily augments the fasting level of triglycerides.The present investigation deals with the rela- tionship of plasma free fatty acids (plasma FFA) to fasting plasma triglycerides (plasma TG) in man.From these observations a quantitative as- sessment of the amount of plasma FFA converted to plasma TG will be presented.The data also permit calculations which suggest that plasma FFA may be the major source of fasting plasma TG. METHODSTwo types of studies were carried out in male patients without known abnormalities of fat metabolism.1. Non-reinjection experiments.After an overnight fast of 15 hours, 9 subjects were given 0.004 to 0.008 mc albumin-bound palmitic acid-i-C1' intravenously either by single injection or by 2-hour constant infusion.Two individuals received 0.00585 mc of albumin-bound oleic acid-i-C1' and another 0.00597 mc of stearic acid-1-C14.During the day of the study the subjects were permitted no breakfast, a nonfat lunch, and an unrestricted supper.Venous blood samples were drawn at appropriate in- tervals over a period of 24 hours after administration of fatty acid C1' for determination of neutral fat activity.Two-ml aliquots of plasma were extracted by the method of Dole (1).Eight ml of the upper phase, representing 1.85 ml of plasma, was transferred to a separate tube.Ten ml of 0.1 N NaOH in 50 per cent ethanol was added, according to the method of Borgstrbm (2), in order to
Pyruvate kinase deficiency associated with severe liver dysfunction in the newborn
Authors: Martine F. Raphaël, Richard Van Wijk, Joachim J. Schweizer, Netteke A.Y. Schouten‐van Meeteren, Angelika Kindermann, Wouter W. van Solinge, Frans J. Smiers
Journal: American Journal of Hematology (2007)

Significant hyperbilirubinaemia, anemia, and splenomegaly are common features in patients with severe haemolysis due to pyruvate kinase (PK) deficiency. Until now, severe neonatal PK deficiency has not been associated with fatal liver disease at this age. We present two neonatal cases of severe PK deficiency complicated with progressive fatal liver disease. The patients presented with severe haemolysis, progressive cholestasis, and hepatosplenomegaly, and both patients ultimately developed liver failure at a very young age. Despite extensive investigations, no specific explanation for liver disease and failure was found. We suggest that the PK deficiency itself directly led to liver dysfunction.
Predictive value of alkaline phosphatase for response and time to progression in bortezomib‐treated multiple myeloma patients
Authors: Maurizio Zangari, Dixie Esseltine, Federica Cavallo, Rachel Neuwirth, Francesca Elice, Michael J. Burns, Shmuel Yaccoby, Paul Richardson, Pieter Sonneveld, Guido Tricot
Journal: American Journal of Hematology (2007)

Myeloma bone disease is characterized by osteolytic destruction associated with suppressed osteoblastic activity. Using data from the APEX (Richardson et al., N Engl J Med 2005;352:2487-2498) study, we have assessed the relationship of changes in alkaline phosphatase (ALP) levels during bortezomib therapy with response and time to progression on this therapy. The percentage of ALP increments in responders (complete and partial response) and nonresponders was analyzed at different thresholds and time points. For all bortezomib-treated patients enrolled in the trial (N = 333), at least a 25% increase in ALP from the baseline at 6 week was the most powerful predictor of treatment response (P < 0.0001) and time to progression (206 vs. 169 days) relative to patients with less than a 25% increase in ALP (P = 0.01). Markers of osteoblastic activation may predict quality and duration of response in multiple myeloma. In addition, our data suggest that bone anabolism could inhibit myeloma growth.
New Knowledge for New Results: A Comprehensive Strategy for Reducing Skyrocketing Medical Costs
Authors: Ann Hendricks
Journal: Annals of Internal Medicine (2009)

Medical Writings: Book Notes3 November 2009New Knowledge for New Results: A Comprehensive Strategy for Reducing Skyrocketing Medical CostsAnn Hendricks, PhDAnn Hendricks, PhDFrom the Veterans Affairs Boston Healthcare System and Boston University School of Public Health, Boston, Massachusetts.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-151-9-200911030-00026 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Herron RE. 232 pages. Fairfield, IA: 1st World Publishing; 2008. $24.95. ISBN 9781421898421. Order at www.1stworldpublishing.com/store.Field of medicine: Preventive care, chronic disease, and alternative therapies.Format: Hardcover book.Audience: Readers interested in efforts to achieve health care reform, whether pro or con.Purpose: To describe the reasons that health care reform is urgent for the United States and the changes in the system that could improve health outcomes and lower national expenditures.Content: This book has 4 sections: statement of the problem, alternative medical approaches to help people achieve greater health, the need for more preventive and primary care ... Author, Article, and Disclosure InformationAffiliations: From the Veterans Affairs Boston Healthcare System and Boston University School of Public Health, Boston, Massachusetts. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 3 November 2009Volume 151, Issue 9Page: 676KeywordsAntidotesHealth careHealth care utilizationInformation theoryMotivationPrevention, policy, and public healthPreventive medicinePrimary careSmoking habitsVeteran care ePublished: 3 November 2009 Issue Published: 3 November 2009 Copyright & PermissionsCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Intracellular cholesterol transport
Authors: Frederick R. Maxfield, Daniel Wüstner
Journal: Journal of Clinical Investigation (2002)

Cholesterol is the single most abundant lipid species in mammalian cells. More than 2×109 years of evolution designed this molecule to perfectly fit into phospholipid bilayers regulating the fluidity, permeability and bending stiffness of biological membranes. Cholesterol also serves as a precursor of steroid hormones, bile acids and oxysterols, and its cellular synthesis is regulated by a complex machinery. While the molecular mechanisms underlying cholesterol synthesis are known in great detail, knowledge is rather sparse about the inter-compartment transport of cholesterol, including trafficking modes and kinetics, as well as control of endomembrane cholesterol content. This chapter provides an overview of our recent understanding of intracellular transport of cholesterol. It is aimed to create a link between the well characterized biophysical properties of cholesterol in model membranes and its behavior in living cells.
Update on skin allergy
Authors: C. Schlapbach, D. Simon
Journal: Allergy (2014)

Skin diseases with an allergic background such as atopic dermatitis, allergic contact dermatitis, and urticaria are very common. Moreover, diseases arising from a dysfunction of immune cells and/or their products often manifest with skin symptoms. This review aims to summarize recently published articles in order to highlight novel research findings, clinical trial results, and current guidelines on disease management. In recent years, an immense progress has been made in understanding the link between skin barrier dysfunction and allergic sensitization initiating the atopic march. In consequence, new strategies for treatment and prevention have been developed. Novel pathogenic insights, for example, into urticaria, angioedema, mastocytosis, led to the development of new therapeutic approaches and their implementation in daily patient care. By understanding distinct pathomechanisms, for example, the role of IL-1, novel entities such as autoinflammatory diseases have been described. Considerable effort has been made to improve and harmonize patient management as documented in several guidelines and position papers.
Requirements of British universities for higher medical degrees.
Authors: R Johnson
Journal: BMJ (1991)

OBJECTIVE--To examine the requirements and opportunities for obtaining a doctor of medicine or master of surgery degree from a university in the United Kingdom other than the graduate9s own, particularly in the case of foreign graduates. DESIGN--Review of regulations governing the award of doctor of medicine and master of surgery degrees in British universities. SETTING--All 19 universities in the United Kingdom offering clinical courses. MAIN OUTCOME MEASURE--Availability of degrees to graduates of other universities. RESULTS--Opportunities for obtaining a degree differed widely among the medical schools, one university (Edinburgh) not admitting graduates of other universities in any circumstance. Of the remaining universities, none would consider a graduate who had not worked in the area where the medical school was located. CONCLUSION--The wide differences in opportunity among the medical schools may put some foreign graduates at a disadvantage compared with other graduates. This problem may become more severe as the number of graduates from the European Community who settle in Britain increases.
NASAL DEFORMITIES ASSOCIATED WITH CONGENITAL CLEFT OF THE LIP
Authors: P. BLAIR
Journal: JAMA (1925)

The results of operative repair of harelip vary from nearly perfect to plain bad; but, unless the original operator has been more than ordinarily inconsiderate in his denudation and suturing, the tissues can usually, by secondary operation, be rearranged to produce an approximately happy result. One or several abnormalities may cause the repaired lip to be displeasingly noticeable. Among these, the most common are ugly scars, notched lip, poor approximation of the vermilion border, increase in length of the upper lip at the expense of its width with a resulting narrowing of the mouth slit, flatness of the upper lip, and protrusion of the lower lip. On the other hand, the upper lip may be too short. Loss of the premaxilla is rare, but quite disfiguring. If the denuding incision is made within the thin tissue that may border a cleft, there will be a characteristic and very ugly bulging
Transradial angiography may deleteriously affect patency of radial artery grafts
Authors: Cheng-Hon Yap, James F Kenny
Journal: BMJ (2004)

EDITOR—The review by Archbold et al comprehensively outlines the many advantages of radial access.1 However, it does not touch on the potential harmful effects that such an approach may have on the patency of radial artery grafts when patients later have coronary artery bypass grafts.

Current interest in the use of radial …
Angiosarcoma in patients with xeroderma pigmentosum: Less aggressive and not so rare?
Authors: Raymond Karkouche, Delphine Kerob, Maxime Battistella, Nadem Soufir, Smail Hadj-Rabia, Martine Bagot, Céleste Lebbé, Emmanuelle Bourrat
Journal: Journal of the American Academy of Dermatology (2013)
Cantharidin Poisoning Due to a "Blister Beetle"
Authors: S. G. Browne
Journal: BMJ (1960)

GASTRIC TUBERCULOSIS BmOURLThis comment may apply to other cases of the disease, even in the absence of any overt sign of another tuberculous focus.Summary A case of tuberculosis of the stomach is described.The diagnosis was made from the histological study of tissue removed by partial gastrectomy, undertaken because of intractable abdominal pain, which recurred after operation.Two years later the patient developed a psychotic state after two weeks' treatment with streptomycin and isoniazid, given because of tuberculous adenitis and abdominal pain.The abdominal pain and enlargement of lymph nodes subsided after two months' antituberculous chemotherapy.REFERENCES