tbuckley/cabot-search huggingface dataset:
Hypoxemia during Air Travel
Authors: Jeffreys. Schwartz
Journal: Annals of Internal Medicine (1990)

Letters and Corrections15 January 1990Hypoxemia during Air TravelJeffreys. Schwartz, MDJeffreys. Schwartz, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-112-2-147_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:The study by Dillard and associates ( 1 ) concerning hypoxemia during air travel in patients with chronic obstructive pulmonary disease contains a flaw in its design that likely affects the results. The investigators did spirometry and measured arterial blood gases immediately before altitude simulation. As suggested by our earlier study (2), the finding that sea-level arterial blood oxygen tension (PaO2) and forced expiratory volume in one second (FEV1) can be used to accurately determine Pao2at 8000 feet may not be accurate when the measurements are done days or weeks before flight. Although sea-level Pao2in...References1. DillardBergRajagopal TBK. Hypoxemia during air travel in patients with chronic obstructive pulmonary disease. Ann Intern Med. 1989;111:362-7. LinkGoogle Scholar2. SchwartzBencowitzMoser JHK. Air travel hypoxemia with chronic obstructive pulmonary disease. Ann Intern Med. 1984;100:473-7. LinkGoogle Scholar3. Gong H Advising patients with pulmonary diseases on air travel. Ann Intern Med. 1989;111:349-51. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Jeffreys. Schwartz, MDAffiliations: Colorado Pulmonary Associates, P.C. Denver, CO 80218 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 January 1990Volume 112, Issue 2Page: 147-148KeywordsArterial partial pressure of oxygenBloodBlood volumeChronic obstructive pulmonary diseaseForced expiratory volumeForced expiratory volume in the first second of expirationHypoxiaOxygenSpirometry ePublished: 1 December 2008 Issue Published: 15 January 1990 PDF downloadLoading ...
Clinical Significance of Increased Temporomandibular Joint Uptake by Planar Isotope Bone Scan
Authors: DAVID H. EPSTEIN, ROBERT W. GRAVES, WILLIAM L. HIGGINS
Journal: Clinical Nuclear Medicine (1987)

Previous studies have suggested a role for the isotope bone scan in the evaluation of patients with temporomandibular joint (TMJ) related symptoms. The studies have not evaluated the frequency or significance of increased TMJ uptake in a random population. One hundred fourteen patients receiving routine bone scans were asked to complete questionnaires regarding TMJ symptoms. The data show that marked TMJ uptake is relatively rare (4%) and correlated with appropriately lateralizing symptoms in all cases. Lesser degrees of increased TMJ uptake correlated poorly (50% symptomatic). The authors suggest that increased TMJ uptake is a significant finding on routine isotope bone scans. The role of the isotope bone scan in the symptomatic patient remains unclear.
643 A PROSPECTIVE STUDY OF THE DIAGNOSTIC ACCURACY OF TRANSIENT ELASTOGRAPHY (FIBROSCAN®) IN THE EVALUATION OF HEPATIC FIBROSIS IN ASIANS COMPARED WITH LIVER BIOPSY AND APRI
Authors: P.E.J. Chang, H.F. Lui, Y.P. Chau, K.H. Lim, W.M. Yap, C.K. Tan, W.C. Chow
Journal: Journal of Hepatology (2008)
Fas ligation induces IL-1β-dependent maturation and IL-1β-independent survival of dendritic cells: different roles of ERK and NF-κB signaling pathways
Authors: Zhenhong Guo, Minghui Zhang, Huazhang An, Weilin Chen, Shuxun Liu, Jun Guo, Yizhi Yu, Xuetao Cao
Journal: Blood (2003)
309 Human cholangiocarcinoma cells express leptin receptors and respond to leptin with increase of proliferation
Authors: G. Fava, G. Alpini, C. Rychlicki, G. Svegliati-Baroni, A. di Sario, S. De Morrow, H. Francise, J. Venter, S. Glaser, R. Reichenbach, A. Benedetti
Journal: Journal of Hepatology (2006)
Skin Testing in Penicillin Allergy.
Authors: C. W. Parker
Journal: Annals of Internal Medicine (1963)

s1 April 1963Skin Testing in Penicillin Allergy.C. W. Parker, M.D., J. A. Thiel, M.D.C. W. Parker, M.D.Search for more papers by this author, J. A. Thiel, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-4-738_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptBased on immunologic principles established in the experimental animal, human penicillin hypersensitivity must be presumed to be due to groups formed by the degradation of penicillin and capable of covalent binding to protein. Three such groups are the penicilloyl, penicillenate, and penamaldate derivatives. Based on wheal-and-erythema responses using derivatives containing these groups in the skin of persons with penicillin allergy, hypersensitivity to the penicilloyl group has been found to be very common in penicillin hypersensitivity. Allergy to penicillenate and penamaldate groups appears to be considerably less common.In large-scale testing of human subjects, a polymer of lysine has been used... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: C. W. Parker, M.D.; J. A. Thiel, M.D.Affiliations: St. Louis, Mo. (CI) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byInfectious Diseases: Annual Review of Significant Publications 1 April 1963Volume 58, Issue 4Page: 738-738KeywordsAllergy and immunologyHypersensitivityLysinePenicillinProteolysis ePublished: 1 December 2008 Issue Published: 1 April 1963 PDF downloadLoading ...
Double Guide Wire Placement for Endoscopic Pancreaticobiliary Procedures
Authors: T. Gyökeres, J. Duhl, M. Varsányi, R. Schwab, M. Burai, Á. Pap
Journal: Endoscopy (2003)

The large working channel of a new generation of duodenoscopes permits side-by-side double guide wire placements, which can facilitate both cannulation and drainage during pancreaticobiliary procedures [1]. The use of two guide wires in one duct can make therapeutic endoscopy easier during drainage procedures. It is employed by many endoscopists for bilateral drainage of strictures in the biliary duct [1] [2]. A similar method for stent insertion, employing a double guide wire, can also be applied during cystoenterostomies [3].
Differences between men and women in hospital mortality associated with coronary artery bypass graft surgery. The Northern New England Cardiovascular Disease Study Group.
Authors: G T O'Connor, J R Morton, M J Diehl, E M Olmstead, L H Coffin, D G Levy, C T Maloney, S K Plume, W Nugent, D J Malenka
Journal: Circulation (1993)

BACKGROUND A prospective study of patients undergoing coronary artery bypass graft surgery (CABG) was conducted to examine differences in hospital mortality by sex. Outcome data on 3055 CABG patients undergoing operation between 1987 and 1989 were examined for differences in patient, disease, and treatment factors. METHODS AND RESULTS Odds ratios (OR), risk differences, and 95% confidence intervals (CI95%) were calculated. Mortality rates for women (7.1%) and men (3.3%) differed, the OR (women versus men) being 2.23 (CI95%, 1.58 to 3.15). Women were older, more often diabetic, and had more urgent or emergent surgery; adjustment yielded an OR (women versus men) of 1.75 (CI95%, 1.17 to 2.63). Body surface area (BSA) was associated with risk of death in both sexes (P = .007) and positively associated with coronary artery luminal diameters. After adjustment for BSA, sex was no longer significantly associated with mortality (OR [women versus men] of 1.18; CI95%, 0.72 to 1.95). Internal mammary artery (IMA) grafting was performed less frequently among women than men (64.8% versus 78.4%, P &lt; .001). Smaller BSA and absence of IMA grafting were each associated with increased risk of death (RD) from heart failure. Risk of death from heart failure (RD [women minus men] = 2.05; CI95%, 0.89 to 3.22) and hemorrhage (RD [women minus men] = 0.63; CI95%, 0.13 to 1.13) was greater among women; these accounted for 71.1% of the sex-specific difference in mortality rates. CONCLUSIONS Excess risk of hospital mortality among women having CABG was largely the consequence of death from heart failure and, to a lesser extent, from hemorrhage. Smaller BSA (probably because of its association with coronary artery luminal diameter) and the absence of IMA grafting were each associated with increased risk of death from heart failure.
Effect of frequent ventricular ectopy on myocardial infarct size in dogs
Authors: S. NATTEL, S. BEAU, G. McCARRAGHER
Journal: Cardiovascular Research (1987)

Journal Article Effect of frequent ventricular ectopy on myocardial infarct size in dogs Get access STANLEY NATTEL, STANLEY NATTEL From the Departments of Pharmacology and Therapeutics and of Medicine, McGill University; and Divisions of Cardiology and Clinical Pharmacology, Montreal General Hospital, Montreal, Canada Address for correspondence and reprints: Dr S Nattel, Department of Pharmacology, McGill University, 3655 Drummond St, Montreal, Quebec, Canada H3G 1Y6. Search for other works by this author on: Oxford Academic PubMed Google Scholar SCOTT BEAU, SCOTT BEAU From the Departments of Pharmacology and Therapeutics and of Medicine, McGill University; and Divisions of Cardiology and Clinical Pharmacology, Montreal General Hospital, Montreal, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar GARY McCARRAGHER GARY McCARRAGHER From the Departments of Pharmacology and Therapeutics and of Medicine, McGill University; and Divisions of Cardiology and Clinical Pharmacology, Montreal General Hospital, Montreal, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 21, Issue 4, April 1987, Pages 286–292, https://doi.org/10.1093/cvr/21.4.286 Published: 01 April 1987 Article history Received: 29 April 1986 Accepted: 27 August 1986 Published: 01 April 1987
Metabolic Control Matters: Why Is the Message Lost in the Translation?
Authors: Howard A. Wolpert, Barbara J. Anderson
Journal: Diabetes Care (2001)

The scientific evidence is clear: metabolic control matters. The question is, why doesn’t this message persuade most patients? In this letter, we address one important consideration: goal-setting and its role in promoting behavioral change and improved glycemic control. The conclusive evidence from the Diabetes Control and Complications Trial (DCCT) (1) and the U.K. Prospective Diabetes Study (UKPDS) (2) that established causality between glycemic control and the microvascular complications of diabetes has highlighted the importance of the glycohemoglobin level as a critical predictor of future health. Inevitably, the focus of diabetes care and the interaction between the patient and clinician has increasingly become directed around self-monitoring of blood glucose (SMBG) records and glycosylated hemoglobin measurements (3). However, despite this evidence for the efficacy of tight glycemic control, as pointed out in a recent article in Diabetes Care by Narayan et al. (4), translation of these goals into clinical practice has generally been unsuccessful.

The Clinical Practice Recommendations of the American Diabetes Association (ADA) suggest a treatment HbA1c standard of <7% and a blood glucose self-measurement target of 80–120 mg/dl before meals and of 100–140 mg/dl at bedtime in patients who do not have severe or unrecognized hypoglycemia (5). These targets are similar to those recommended by the American Association of Clinical Endocrinologists (6). For the patient …
Importance of indoor allergens in the induction of allergy and elicitation of
Authors: A. Custovic, A. Simpson, A. Woodcock
Journal: Allergy (1998)

During the last few decades, many countries have experienced an increase in the prevalence and severity of asthma. Over the same period, the population in the developed world has retreated indoors, and homes have become better insulated and more energy efficient, resulting in a warm and humid environment with low ventilation rates, ideally suited to house-dust-mite population growth throughout the year. Increasing exposure and increasing sensitivity to indoor allergens represent a progressively higher risk factor for the development of asthma. The development of sensitivity to indoor allergens and the symptoms and severity of asthma in later childhood are directly related to the exposure to allergens in infancy. It was relatively straightforward to demonstrate a quantitative linear dose-response relationship between exposure to house-dust-mite allergens and subsequent sensitization. However, showing the same for exposure and asthma severity has been more difficult, as the relationship between exposure and asthma symptoms in already sensitized individuals is much more complex than in the case of exposure and sensitization. Nevertheless, sensitized individuals are likely to have more severe asthma if exposed to high allergen levels than if their level of exposure is low. Sensitization to house-dust mites is a major independent risk factor for asthma in all areas where climate is conducive to mite population growth. The relevance of allergens other that mite is not consistent between different areas, and depends on the climate, habits, and socio-economic features of the local community. It would appear that presence of mite allergens in homes "overshadows" other allergens (e.g., cat, dog, or cockroach) as a risk factor for sensitization and subsequent development of allergic disease. It is possible that this is the consequence of the difference in inherent potency between allergen sources, and the question of why mite allergens are so potent in inducing sensitization and atopic disease remains to be answered.
Cytogenetic monitoring of human populations at risk in Egypt: role of cytogenetic data in cancer risk assessment.
Authors: W A Anwar
Journal: Environmental Health Perspectives (1991)

Somatic mutation plays a critical role in carcinogenesis. Numerous environmental agents can increase the probability that somatic mutation will occur. The use of genotoxicity testing is essential for assessing potential human toxicity so that hazards can be prevented. Cytogenetic monitoring of human populations exposed to chemicals has proved to be a useful tool for detecting the chemical mutagenic effects. Cytogenetic analyses of human chromosomes in peripheral lymphocytes allows direct detection of mutation in somatic cells. Different methods can be used for chromosomal analysis (conventional chromosomal analysis, sister chromatid exchange, micronucleus frequency detection). Micronucleus frequency can be detected either in peripheral blood lymphocytes or in exfoliated cells. Different examples of human population studies are presented. Several problems that are found in biomonitoring studies are discussed. These studies should help us learn about individual exposure assessment and biologically relevant doses, leading to quantitative assessment of human cancer risks.
The Shifting Mission of Health Care Delivery Organizations
Authors: Richard M.J. Bohmer, Thomas H. Lee
Journal: New England Journal of Medicine (2009)

An important transition has begun in payment for health care delivery in the United States: organizations that have long been paid for transactions, such as visits or procedures, are beginning — at least in some markets — to be paid instead for producing outcomes. As physicians and hospital leaders contemplate the implications of new payment models, they realize that the transition will be long, difficult, and messy, with major ramifications for providers.After decades of discussion about the problems inherent in fee-for-service medicine, skepticism about whether real change is under way would be understandable. But it would be reckless in . . .
Tiam1/Rac1 signals contribute to the proliferation and chemoresistance, but not motility, of chronic lymphocytic leukemia cells
Authors: Sebastian W. Hofbauer, Peter W. Krenn, Sylvia Ganghammer, Daniela Asslaber, Ulrike Pichler, Karin Oberascher, Reinhard Henschler, Michael Wallner, Hubert Kerschbaum, Richard Greil, Tanja N. Hartmann
Journal: Blood (2014)
Vasomotor Responses to Cooling in the Extremities of Subjects with Neurologic Lesions
Authors: K. DE CRINIS, W. REDISCH, A. ANTONIO, A. BOGDANOVITZ, J. M. STEELE, Gordon Gilbert, Raleigh Wheeler
Journal: Circulation (1959)

Reflex vascular responses to cooling were studied in subjects with neurologic disorders, with a younger and an elderly "normal" group being used for comparison. By and large the responses were mirror images of those described for the Gibbon-Landis procedure. It was demonstrated that normal reflex responses to cooling as well as to warming are dependent upon the integrity of sympathetic innervation.
The iron-H2O2-iodide cytotoxic system.
Authors: S J Klebanoff
Journal: The Journal of Experimental Medicine (1982)

A potent antimicrobial system is described which consists of ferrous sulfate (Fe2+), hydrogen peroxide (H2O2), and iodide in 0.02 M sodium acetate buffer pH 5.5. H2O2 could be replaced by the H2O2-generating system glucose + glucose oxidase. This system, unlike the myeloperoxidase-H2O2-halide system, was ineffective when iodide was replaced by bromide, chloride, or thyroxine, and was inhibited by EDTA, the hydroxyl radical scavengers mannitol and ethanol, and phosphate and lactate buffers at the same concentration and pH as the acetate buffer used. The acetate buffer, however, could be replaced by water. It is proposed that Fe2+ and H2O2 (Fenton's reagent) generate OH X (or a closely related substance), which interacts with iodide to form one or more toxic species.
Abstract 3563: New tools for RNA-sequencing of FFPE tumor samples
Authors: Lisa Watson, Smita Pathak, Stephen Gross, Irina Khrebtukova, Gary Schroth
Journal: Cancer Research (2014)

Abstract Next generation RNA sequencing is an ideal platform to leverage archival formalin-fixed paraffin-embedded (FFPE) tissue samples for cancer research, as it offers extensive functional genomic information including transcriptome expression profiling, differential expression analysis and fusion detection. However, both RNA degradation from the formalin fixation process as well as limited sample material, pose major challenges for RNA sequencing of FFPE samples. Here we describe a novel method for generating whole-transcriptome RNA sequencing libraries from moderate to poor quality FFPE samples starting with as low as 20ng total RNA. This approach provides increased transcriptome coverage and robust measurement of gene expression levels compared to currently available FFPE RNA sequencing methods. Furthermore, we demonstrate that we can detect both known and novel gene fusions in clinical tumor samples that are potential drivers of disease. We anticipate this new technology will enable functional genomic studies on numerous FFPE tumor samples that would not previously be possible, providing invaluable information for developing cancer diagnostics and therapeutics. Citation Format: Lisa Watson, Smita Pathak, Stephen Gross, Irina Khrebtukova, Gary Schroth. New tools for RNA-sequencing of FFPE tumor samples. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3563. doi:10.1158/1538-7445.AM2014-3563
FunMod: A Cytoscape Plugin for Identifying Functional Modules in Undirected Protein–Protein Networks
Authors: Massimo Natale, Alfredo Benso, Stefano Di Carlo, Elisa Ficarra
Journal: Genomics Proteomics & Bioinformatics (2014)

Abstract The characterization of the interacting behaviors of complex biological systems is a primary objective in protein–protein network analysis and computational biology. In this paper we present FunMod, an innovative Cytoscape version 2.8 plugin that is able to mine undirected protein–protein networks and to infer sub-networks of interacting proteins intimately correlated with relevant biological pathways. This plugin may enable the discovery of new pathways involved in diseases. In order to describe the role of each protein within the relevant biological pathways, FunMod computes and scores three topological features of the identified sub-networks. By integrating the results from biological pathway clustering and topological network analysis, FunMod proved to be useful for the data interpretation and the generation of new hypotheses in two case studies.
Associations between Nighttime Traffic Noise and Sleep: The Finnish Public Sector Study
Authors: Jaana I. Halonen, Jussi Vahtera, Stephen Stansfeld, Tarja Yli-Tuomi, Paula Salo, Jaana Pentti, Mika Kivimäki, Timo Lanki
Journal: Environmental Health Perspectives (2012)

Associations between traffic noise and sleep problems have been detected in experimental studies, but population-level evidence is scarce.We studied the relationship between the levels of nighttime traffic noise and sleep disturbances and identified vulnerable population groups.Noise levels of nighttime-outdoor traffic were modeled based on the traffic intensities in the cities of Helsinki and Vantaa, Finland. In these cities, 7,019 public sector employees (81% women) responded to postal surveys on sleep and health. We linked modeled outdoor noise levels to the residences of the employees who responded to the postal survey. We used logistic regression models to estimate associations of noise levels with subjectively assessed duration of sleep and symptoms of insomnia (i.e., difficulties falling asleep, waking up frequently during the night, waking up too early in the morning, nonrestorative sleep). We also used stratified models to investigate the possibility of vulnerable subgroups.For the total study population, exposure to levels of nighttime-outside (L(night, outside)) traffic noise > 55 dB was associated with any insomnia symptom ≥ 2 nights per week [odds ratio (OR) = 1.32; 95% confidence interval (CI): 1.05, 1.65]. Among participants with higher trait anxiety scores, which we hypothesized were a proxy for noise sensitivity, the ORs for any insomnia symptom at exposures to L(night, outside) traffic noises 50.1-55 dB and > 55 dB versus ≤ 45 dB were 1.34 (95% CI: 1.00, 1.80) and 1.61 (95% CI: 1.07, 2.42), respectively.Nighttime traffic noise levels > 50 dB L(night, outside) was associated with insomnia symptoms among persons with higher scores for trait anxiety. For the total study population, L(night, outside) > 55 dB was positively associated with any symptoms.
The Promised End — Constitutional Aspects of Physician-Assisted Suicide
Authors: George J. Annas
Journal: New England Journal of Medicine (1996)

The debate over physician-assisted suicide has dramatically shifted to a discussion of constitutional issues. This spring, within a month of each other, U.S. Circuit Courts of Appeals on both coasts ruled that state prohibitions of assisted suicide are unconstitutional when applied to physicians who prescribe lethal medication for terminally ill, competent adults who wish to end their lives.1,2 The Ninth Circuit includes Alaska, Arizona, California, Hawaii, Idaho, Montana, Nevada, Oregon, and Washington, and the Second Circuit includes New York, Connecticut, and Vermont. Both courts reached the same conclusion but for different legal reasons.In the Ninth Circuit, four physicians . . .