tbuckley/cabot-search huggingface dataset:
The Place of Nodal Dissection
Authors: William J. Staubitz
Journal: JAMA (1970)

Testis tumor is not a common disease; it accounts for only 1.5% of all malignancies in males. Although it is uncommon, it is very significant because it is found most frequently in the young adult at an average age of 33 years. The fact that it threatens the life of the patient during his most productive years stresses the importance of the need for an aggressive approach to treatment in an effort to prolong the life of an individual whose contributions to his family and society are vital. In an effort to increase survival rates in patients with testis tumor, much effort has been put forth in the development of surgical techniques for the treatment of this disease. One such effort has been the development of retroperitoneal lymph node dissection. First, the unilateral approach was tried and then later a bilateral lymphadenectomy was developed. This report will outline our experience
Nutrition and Disease of the Liver
Authors: Charles S. Davidson, George J. Gabuzda
Journal: New England Journal of Medicine (1950)

THE pathogenesis and therapy of liver disease are considered in some measure nutritional problems. The purpose of this paper is to survey the evidence implicating nutritional deficiency in the etiology of liver disease in man and contrariwise to point out the effects of established liver disease upon nutrition. Finally, the therapeutic implications derived from the facts available are presented.The discussion is largely confined to the problems as they concern liver disease in man. Although animal studies are the origin of most of the fundamental knowledge, only a small fraction of the literature germane to such studies is included. Since . . .
TOXIC CIRRHOSIS OF THE LIVER DUE TO "HYDROCIN" (50 PER CENT CINCHOPHEN)
Authors: Donald W. Ingham
Journal: JAMA (1933)

Since cinchophen has been used as an analgesic, particularly in the treatment of arthritis and allied conditions, there have been many contributions to medical literature regarding its toxicity and the signs and symptoms subsequent to the toxic action. A brief concise review of the literature on this subject was given by Weis1in 1932. Since that time there have been numerous reports, but the following case fits in well with the cases reported by Parsons and Harding.2  REPORT OF CASE  Mrs. F. B., aged 63, was admitted in coma, Sept. 9, 1933, at 4:55 p. m., in the service of Drs. J. L. Atlee, Jr., and Harvey Seiple, in the Lancaster General Hospital. The history was obtained from one of the patient's daughters. The patient had been sick for over a year with arthritis and had been treated by a physician with some degree of improvement, but in
Neuropeptide Y modulates vasoconstriction in coronary microvessels in the beating canine heart.
Authors: T Komaru, K Ashikawa, H Kanatsuka, N Sekiguchi, T Suzuki, T Takishima
Journal: Circulation Research (1990)

The purpose of this study was to determine whether neuropeptide Y has a direct vasoconstrictor effect at low doses, mimicking the physiological plasma concentration on the specific site(s) of coronary arterial microvessels in in situ beating canine left ventricles. Coronary microvessels were directly observed by means of an intravital microscope and video system equipped with a floating objective. Epi-illuminated fluorescence coronary microangiography was performed in open-chest anesthetized dogs (n = 14) to examine the changes in internal diameter of epimyocardial arterial microvessels. Flow velocity of fluorescently labeled microshperes in capillaries was also measured (n = 6). To eliminate secondary effects of neuropeptide Y on coronary microvessels via autonomic nervous modulation, experiments were conducted under pharmacological blockade of the regional autonomic nervous system by intracoronary injection of propranolol, 50 micrograms/kg; phentolamine, 100 micrograms/kg; and atropine, 5 micrograms/kg. Aortic pressure and heart rate were kept constant during the experiments. Intracoronary infusion of three different doses of neuropeptide Y (1, 10, and 100 pmol/kg/min) for 5 minutes significantly constricted small microvessels (less than 100 microns in diameter) (-5.2 +/- 1.4%, -8.5 +/- 1.5%, and -14.0 +/- 1.7%; p less than 0.05 versus before neuropeptide Y at each dose), medium microvessels (100-200 microns in diameter) (-5.5 +/- 1.6%, -10.6 +/- 1.8%, and -16.8 +/- 2.1%, p less than 0.05 versus before neuropeptide Y at each dose), and large microvessels (greater than 200 microns in diameter) (-3.6 +/- 0.6%, -5.8 +/- 0.8%, and -10.0 +/- 1.1%; p less than 0.05 versus before neuropeptide Y at each dose) in a dose-dependent manner. Capillary flow velocity was reduced by 17.2 +/- 3.1% by an intracoronary dose of 100 pmol/kg/min of neuropeptide Y (p less than 0.05). The present study indicates that low doses of neuropeptide Y exert a homogeneous direct vasoconstrictor effect on various sizes of coronary arterial microvessels and reduce capillary flow velocity. These results suggest that neuropeptide Y may play a physiological role in modulating coronary microvascular tone.
Developmental Exposure to PCBs, MeHg, or Both: Long-Term Effects on Auditory Function
Authors: Brian E. Powers, Emily Poon, Helen J.K. Sable, Susan L. Schantz
Journal: Environmental Health Perspectives (2009)

Developmental exposure to polychlorinated biphenyls (PCBs) or methylmercury (MeHg) can result in a variety of neurotoxic effects, including long-term auditory deficits. However, little is known about the effects of combined exposure to PCBs and MeHg on auditory function.We developmentally exposed rats to PCBs and/or MeHg and assessed auditory function in adulthood to determine the effects of exposure to these contaminants individually and in combination.We exposed female Long-Evans rats to 1 or 3 mg/kg PCB in corn oil, 1.5 or 4.5 ppm MeHg in drinking water, or combined exposure to 1 mg/kg PCB + 1.5 ppm MeHg or 3 mg/kg PCB + 4.5 ppm MeHg. Controls received corn oil vehicle and unadulterated water. Dosing began 28 days before breeding and continued until weaning at postnatal day (PND) 21. Auditory function of the offspring was assessed at approximately PND 200 by measuring distortion product otoacoustic emissions (DPOAEs) and auditory brainstem responses (ABRs).Groups exposed to PCBs alone had attenuated DPOAE amplitudes, elevated DPOAE thresholds, and elevated ABR thresholds compared with controls. Groups exposed to MeHg alone did not differ from controls. Unexpectedly, the effects of PCB exposure appeared to be attenuated by coexposure to MeHg.Developmental exposure to PCBs can result in permanent hearing deficits, and the changes in DPOAE amplitudes and thresholds suggest a cochlear site of action. Coexposure to MeHg appeared to attenuate the PCB-related deficits, but the mechanism for this unexpected interaction remains to be determined.
NUTRITIONAL ASPECTS OF FEEDING IN THE UNITED STATES NAVY
Authors: ERNEST W. BROWN
Journal: JAMA (1942)

In approaching the topic of this paper, may I remind the reader that there is no more important single factor in building and maintaining high morale and keenness in naval personnel than an acceptable diet of high nutritive value. In fact, the import of optimum nutrition, in relation to physical fitness, can hardly be overemphasized. Modern naval warfare presents enormously increased hazards and a continuous state of tension, increased tremendously by the advent of air power, a heavy toll being laid on the physical and nervous stamina of the operating personnel. Not only must the food supply be adequate in quantity, but the variety must satisfy the requirements of a well balanced ration. This poses a difficult problem which can be met only by careful preplanning and skilful supervision.  The administrative responsibility for the subsistence activities of the Navy lies in the Supply Corps, which procures, stores, issues, prepares and
Treatment of androgenic disorders with dexamethasone: Dose-response relationship for suppression of dehydroepiandrosterone sulfate
Authors: Geoffrey P. Redmond, Gita P. Gidwani, Manjula K. Gupta, Nita M. Bedocs, Rebecca Parker, Christine Skibinski, Wilma Bergfeld
Journal: Journal of the American Academy of Dermatology (1990)
Risk of Acquiring Gonorrhea and Prevalence of Abnormal Adnexal Findings Among Women Recently Exposed to Gonorrhea
Authors: Richard Platt
Journal: JAMA (1983)

We determined the conditions of 26 women who had recently been exposed to Neisseria gonorrhoeae. Infection was more common among women with more than one exposure (13/14) than among those with one exposure (6/12). Gonococcal infection was significantly associated with the presence of findings on physical examination suggestive of upper genital tract inflammation. Nine of 19 infected women had such findings; no uninfected women did. Among infected women, the prevalence of abnormal physical findings was 47% +/- 23% (95% confidence interval). These findings suggest that upper genital tract involvement is a common early complication of gonococcal infection.
Cryosurgery for axillary hyperhidrosis.
Authors: E C Ashby, J L Williams
Journal: BMJ (1976)

Lassa fever: retrospective diagnosis of two patients seen in Great Britain in 1971Lassa fever was first described by Frame et all in 1970, but it was not until three outbreaks had occurred in Jos, Liberia, and Sierra Leone that the disease attracted general attention,2-4 especially as the mor- tality of these outbreaks averaged 45%.We describe two patients admitted under our care in 1971 who recovered.The diagnosis was confirmed retrospectively by serological tests. Case 1This patient, a nursing sister, had worked in Sierra Leone for nearly four years.On the morning of 10 June 1971 she became ill at Serabu Hospital with general aches and pains, fever, and rigors and treated herself for malaria without improvement.Her temperature persisted and varied between 38' and 40'C, and she had severe anorexia, nausea, and vomiting.Despite courses of chloramphenicol and ampicillin the symptoms persisted and she was transferred to Freetown, where pseudomonal septicaemia was diagnosed and she was given a course of prednisone and cloxacillin.Her condition improved and she was transferred to the Tropical Diseases Unit in Liverpool for further investigation.She arrived by air from Sierra Leone via Las Palmas, with an overnight stop at the airport hospital in London on 8 July.On admission she had been feverish for two days (38'C), had a severe right-sided iridocyclitis, and felt weak.Findings on physical examination were essentially normal, except for slight tenderness in the right hypochondrium.She was managed as a case of pyrexia of unknown origin, isolated in a side ward, and barrier-nursed.Nothing abnormal was found on investi- gation, except for hookwortm and stronglyoides, for which she was treated.Her iridocycitis subsided after a course of subconjunctival hydrocortisone, her condition continued to improve, and she was discharged on 23 July with a diagnosis of ?pseudomonal septicaemia/ ?arbovirus infection.A team from the Communicable Diseases Centre, Atlanta, visiting Sierra Leone in September 1972, tested her serum and found a complement fixation titre to Lassa fever of 1/16, indicating that her illness in June 1971 was undoubtedly Lassa fever.In 1975 the titre had fallen to 1/4. Case 2This patient, a doctor, had been working in Segbwema Hospital, SierraLeone.On 21 September 1971 he developed flu-like symptoms and despite a course of tetracycline by mouth continued to feel ill, his temperature rising to 38°-39°C over the next three days.On 24 September he left Sierra Leone on a scheduled flight "feeling grim," and on arrival in the UK next day proceeded to his home in Kirton, Lincs.On the 27th he still complained of malaise, headache, anorexia, and generalised joint pains.On examination he looked ill, was feverish, and had a sallow complexion.Results of physical
Topical Amitriptyline-Ketamine for the Treatment of Brachioradial Pruritus
Authors: Timothy J. Poterucha, Sinead L. Murphy, Mark D. P. Davis, Paola Sandroni, Richard H. Rho, Roger A. Warndahl, William T. Weiss
Journal: JAMA Dermatology (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Candy at the Cash Register — A Risk Factor for Obesity and Chronic Disease
Authors: Deborah A. Cohen, Susan H. Babey
Journal: New England Journal of Medicine (2012)

Health Care Reform and the Presidential Candidates this option regardless of what the law requires . . .because they are responding to consumer demands in the market.President Obama believes the answer lies in a bigger government that decides what care Americans should receive and how much providers should be paid for it.But his plan has already failed to deliver on virtually every promise he made, and its components are failing as quickly as they go into effect.It must be repealed.I believe the answer lies with patients and families, with reformed insurance markets and fair competition, with strong consumer protections and real entitlement reform.My plan tackles our health care challenges without a federal takeover of the entire system.Instead, it relies on markets over regulations, doctors and patients over bureaucrats, and tailored state programs over a 2700-page "solution" from Washington.
Paediatric anaphylaxis: a 5 year retrospective review
Authors: I. L. De Silva, S. S. Mehr, D. Tey, M. L. K. Tang
Journal: Allergy (2008)

Objective: To describe the demographic characteristics, clinical features, causative agents, settings and administered therapy in children presenting with anaphylaxis. Methods: This was a retrospective case note study of children presenting with anaphylaxis over a 5‐year period to the Emergency Department (ED) at the Royal Children’s Hospital, Melbourne. Results: One‐hundred and twenty‐three cases of anaphylaxis in 117 patients were included. There was one death. The median age of presentation was 2.4 years. Home was the most common setting (48%) and food (85%) the most common trigger. Peanut (18%) and cashew nut (13%) were the most common cause of anaphylaxis. The median time from exposure to anaphylaxis for all identifiable agents was 10 min. The median time from onset to therapy was 40 min. Respiratory features were the principal presenting symptoms (97%). Seventeen per cent of subjects had experienced anaphylaxis previously. Conclusions: This is the largest study of childhood anaphylaxis reported. Major findings are that most children presenting to the ED with anaphylaxis are first‐time anaphylactic reactions and the time to administration of therapy is often significantly delayed. Most reactions occurred in the home. Peanut and cashew nut were the most common causes of anaphylaxis in this study population, suggesting that triggers for anaphylaxis in children have not changed significantly over the last decade.
Supplemental peripheral blood stem cells to decrease marrow rejection in adult patients with severe aplastic anemia
Authors: Chang‐Ki Min, Dong Wook Kim, Jong Wook Lee, Chi Wha Han, Woo Sung Min, Chun Choo Kim
Journal: American Journal of Hematology (2001)

Twenty-two multi-transfused patients with a long duration of severe aplastic anemia (SAA) received a transplant from an HLA-matched donor after cyclophosphamide (CY) plus antithymocyte globulin plus procarbazine using CD34(+) enriched blood stem cells + fresh marrow. Peripheral blood stem cells (PBSC) were collected on days 5 and 6 of G-CSF (10 microg/kg/day), and T cells were depleted using an immunoadsorption column (n = 15) or magnetic cell sorting (n = 7). Marrow harvesting was performed 48 hr after the last leukapheresis. Two patients (9.1%) that developed graft failure had a successful engraftment again using unpurged PBSC. Median time to neutrophils > or = 0.5 x 10(9)/l and platelets > or = 20 x 10(9)/l without platelet transfusions were 12 days and 17 days, respectively. Acute graft-versus-host disease (GVHD) grade II occurred in four of 22 patients. No patient developed grade III or IV acute GVHD. Four of the evaluable 21 patients had chronic GVHD. One patient developed extensive disease. Three patients (13.6%) died from CY-induced heart failure, extensive-type chronic GVHD, and sepsis of unknown cause. The Kaplan-Meier estimate of survival was 83.9% (95% CI, 70.1-95.2%) with a median follow-up duration of 33.5 (6-44) months. CD34(+)-enriched PBSC in combination with unmanipulated marrow seem to play a role in overcoming the sensitization to histocompatibility antigens without an apparent increase in GVHD. The stem cell component therapy may be feasible for the high-risk SAA adult patients.
The New Cholesterol and Blood Pressure Guidelines
Authors: Harlan M. Krumholz
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
In Vitro Activity of Nadifloxacin against both Methicillin-Susceptible and -Resistant Clinical Isolates of Staphylococcus aureus from Patients with Skin Infections
Authors: S. Nishijima, S. Namura, H. Akamatsu, S. Kawai, Y. Asada, S. Kawabata, M. Fujita
Journal: Drugs (1995)
Local Delivery of Enoxaparin to Decrease Restenosis After Stenting: Results of Initial Multicenter Trial
Authors: R. Stefan Kiesz, Pawel Buszman, Jack L. Martin, Ezra Deutsch, M. Marius Rozek, Ewa Gaszewska, Marek Rewicki, Piotr Seweryniak, Maciej Kosmider, Michal Tendera
Journal: Circulation (2001)

Background —Enoxaparin inhibits smooth muscle cell proliferation in experimental models. Intimal hyperplasia has been found to be the principal cause of restenosis after coronary stent implantation. We sought to determine whether the intramural delivery of enoxaparin before stenting of de novo lesions decreases restenosis. Methods and Results —One hundred patients who were undergoing stenting were randomly assigned to either local administration of enoxaparin during predilation with reduced systemic heparinization or stenting with standard, systemic heparinization. All patients were treated with the same type of stent (NIR). The primary study end point was late luminal loss. The secondary end points were major adverse cardiac events, target lesion revascularization, and angiographic restenosis at 6 months. Angiographic follow-up at 6 months was completed in all except 1 patient. Late luminal loss was reduced to 0.76±0.42 mm in the local enoxaparin delivery group versus 1.07±0.49 mm in the systemic heparinization group ( P &lt;0.001). Restenosis, using a binary definition, occurred in 10% of patients in the enoxaparin group and in 24% of patients in the systemic heparinization group ( P &lt;0.05). Target lesion revascularization rates occurred in 8% of the enoxaparin group and 22% of the systemic heparinization group ( P &lt;0.05). There were no deaths and no emergent CABGs were performed. The only subacute stent closure and non–Q-wave infarction occurred in a patient assigned to the systemic heparinization group. Conclusions —This is the first prospective randomized trial in which the local delivery of a drug, enoxaparin, resulted in significant reduction in late luminal loss and restenosis after stent implantation in de novo coronary lesions.
Endogenous antigen presentation impacts on T-box transcription factor expression and functional maturation of CD8+ T cells
Authors: Corey Smith, Diah Elhassen, Stephanie Gras, Katherine K. Wynn, Vijayendra Dasari, Judy Tellam, Siok-Keen Tey, Sweera Rehan, Yu Chih Liu, Jamie Rossjohn, Scott R. Burrows, Rajiv Khanna
Journal: Blood (2012)
Accumulative Prognostic Index for Patients with Barbiturate, Glutethimide and Meprobamate Intoxication
Authors: Abdelmonem A. Afifi, Susan T. Sacks, Vinnie Y. Liu, Max Harry Weil, Herbert Shubin
Journal: New England Journal of Medicine (1971)

Abstract To assess and update prognosis in a group of critically ill patients, repetitive measurements of physiologic status were made in 52 patients who were comatose and in shock after attempting suicide by ingesting large doses of barbiturate, glutethimide or meprobamate. Only three variables were needed to provide the prognostic information contained in all 25 variables measured. A momentary prognostic index, which estimates the patient's probability of survival on the basis of a single set of measurements, and an accumulative prognostic index, which takes into account previous sets of measurements, were derived. The accumulative prognostic index may provide a more realistic assessment of prognosis, for it de-emphasizes transient fluctuations in the patient's condition and emphasizes directional changes as a function of time. Formulas were derived that permit calculation of this index by the clinician with the use of a desk-top calculator.