tbuckley/cabot-search huggingface dataset:
Treatment of Young, Febrile Patients in Long Island, NY
Authors: R. J. Leggiadro
Journal: JAMA (1982)

<h3>To the Editor.—</h3> Previous studies have shown that certain risk factors for bacteremia are applicable to young, febrile patients who make their first visit to an inner-city "walk-in" clinic and are discharged, with or without antimicrobial therapy. Such patients have no focus of infection, an upper respiratory tract infection, pharyngitis, otitis media, or pneumonia, and are not ill enough to be hospitalized. The three risk factors for outpatientbacteremia in this setting are an age between 6 months and 24 months, WBC count of 15,000/cu mm or greater, and a temperature of 38.9 °C or higher.<sup>1</sup> Although one study<sup>2</sup>suggests a similar incidence of bacteremia in such patients in private pediatric practice, how the preceding data relate to a private practice setting remains unclear.<sup>3</sup> A mail survey was conducted to determine how practicing pediatricians on the voluntary staff of the Nassau County Medical Center treat their "patients
USEFULNESS OF PLASMA PENTRAXIN 3 AS A MARKER OF THIN-CAP FIBROATHEROMA IN CORONARY CULPRIT LESION DETERMINED BY OPTICAL COHERENCE TOMOGRAPHY
Authors: Seiji Koga, Satoshi Ikeda, Tomoo Nakata, Takeo Yoshida, Masayoshi Takeno, Yuji Koide, Koji Maemura
Journal: Journal of the American College of Cardiology (2011)
Volvulus of Caecum with Reversed Rotation of Mid-gut
Authors: N. G. Godfrey
Journal: BMJ (1945)

MEDICAL JOUAL 11It is not suggested that penicillin alone was responsible for the happy issue.It is well recognized that the immunity responses may so alter that the outcome of such an illness may well transpire to be other than that first envisaged.Nevertheless I am convinced that penicillin in this instance achieved all that was expected of it, whereas in comparable illnesses of previous outbreaks the intensive use of sulphonamides failed to prevent several fatalities.With the probability of further virulent smallpox reaching our ports, it may well fall to others to confirm the impressions gained from the treatment of this patient.
NEUTRON ACTIVATION ANALYSIS OF TRACE ELEMENTS IN SKIN III. ZINC IN NORMAL SKIN
Authors: MOHAMED M. MOLOKHIA, BENJAMIN PORTNOY
Journal: British Journal of Dermatology (1969)

Journal Article NEUTRON ACTIVATION ANALYSIS OF TRACE ELEMENTS IN SKIN III. ZINC IN NORMAL SKIN Get access MOHAMED M. MOLOKHIA, MOHAMED M. MOLOKHIA Manchester and Salford Hospital for Skin Diseases, Manchester 3 Search for other works by this author on: Oxford Academic Google Scholar BENJAMIN PORTNOY BENJAMIN PORTNOY Manchester and Salford Hospital for Skin Diseases, Manchester 3 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 81, Issue 10, 1 October 1969, Pages 759–762, https://doi.org/10.1111/j.1365-2133.1969.tb15937.x Published: 01 October 1969 Article history Accepted: 27 February 1969 Published: 01 October 1969
Minimal Plain Film Findings of a Femoral Neck Osteoid Osteoma Diagnosed by Radionuclide Bone Scintigraphy and MRI
Authors: JOSEPH A. GAGLIARDI, MARY JO ELINE
Journal: Clinical Nuclear Medicine (1993)

This is a report of scintigraphy and MRI being used to define the vascularity, bone turnover, and secondary marrow changes produced by osteoid osteomas, thus accelerating diagnosis and treatment.
Measuring Blood Pressure Accurately
Authors: Daniel W. Jones, Lawrence J. Appel, Sheldon G. Sheps, Edward J. Roccella, Claude Lenfant
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Peripheral Sensorimotor Neuropathy Associated with a Localized Myeloma
Authors: D. I. Rushton
Journal: BMJ (1965)

Leptospirosis-Parsons MEDICAL JOURNAL 203routine cardiography in patients with uncomplicated leptospirosis are specifically due to that disease.Indeed, it seems probable that they are the non-specific result of a febrile infection.However, previous reports make it clear that pericarditis, endocarditis, and arrhythmias also occur in leptospirosis.These conditions are not seen in artificially induced fever, and cannot be accounted for in this way.Their pathogenesis is unknown, but they could be due to spontaneous bleeding in the myocardium or pericardium.Spontaneous bleeding often occurs in leptospirosis.Nearly half the patients in this series bled from the lungs, the intestine, the skin, the nose, beneath the conjunctiva, or into the cerebro- spinal fluid.A fifth had microscopic haematuria.This bleeding could be very severe indeed.Thus one patient who subsequently recovered from a gross generalized haemorrhagic tendency showed a fall of haemoglobin from 100% to 47%,6 (packed cell volume 19%h) in seven days.A necropsy on a similar fatal case seen elsewhere in Malaya showed that the lungs, pleura, gastro-intestinal tract, retroperitoneal spaces, kidneys, heart, and pericardium were riddled with easily visible haemorrhages of varying sizes.Haemorrhage of this severity is uncommon, but milder internal bleeding must often occur.It is not necessary to surmise such an event to explain the E.C.G. changes observed in this series, but the occurrence of such a spontaneous bleed into the pericardium or into the mvocardium near the conducting tissue could, as suggested by Hume and Szekely (1944), account for the cardiac abnormalities not attributed to exudates, infiltrates, sympathetic overactivity, and fever. SummarySerial electrocardiographic studies were done on 25 patients with leptospirosis and 18 patients with malaria who had no evidence of cardiovascular disease on routine clinical examination.Identical abnormalities were found in the majority of records in the two groups.After comparison with findings reported in artificial hyper- pyrexia, it is concluded that the abnormalities are the non- specific result of a febrile infection.A possible cause of arrhythmias and pericarditis in lepto- spirosis is discussed.I wish to thank Dr.
BASOPHILIC LEUKOCYTES IN ALLERGIC CONTACT DERMATITIS
Authors: Harold F. Dvorak, Martin C. Mihm
Journal: The Journal of Experimental Medicine (1972)

A variety of cell-mediated hypersensitivity reactions in experimental animals include a prominent infiltrate of basophilic leukocytes. This form of reactivity has been designated cutaneous basophil hypersensitivity and is favored when sensitization to several types of antigen is accomplished without the use of complete Freund's adjuvant. A similar type of hypersensitivity response was sought in man using morphologic techniques which permit identification of basophilic leukocytes. Eight individuals with allergic contact dermatitis to a variety of allergens were studied and six of these developed typical contact reactions with erythema, edema, and epidermal vesicles. The microscopic findings in 3-day biopsies from these individuals differed significantly from classic descriptions of tuberculin hypersensitivity and showed, in addition to mononuclear cells and the characteristic epidermal changes, a substantial infiltrate of basophilic leukocytes and evidence of altered vascular permeability with vascular compaction, dermal edema, and fibrin deposition. Serial biopsies from one individual permitted analysis of the microscopic pathology as it unfolded at successive intervals after patch test. The initial lesion consisted of perivascular accumulations of lymphocytes; this was followed by an influx of basophils and, subsequently, of eosinophils. These findings associate contact allergy in man with the parallel reactions of cutaneous basophil hypersensitivity in animals and provide further evidence for the heterogeneity of the cellular immune response. The data are consistent with the hypothesis that interaction between sensitized lymphocytes and antigen, at a local test site, is responsible for the attraction of basophils. They also directly implicate the clotting system in delayed-type reactions and suggest the possibility of a synergistic relationship between cellular immunity and reactions mediated by basophil-bound, homocytotrophic antibody.
No Thought of Prayer
Authors: Harry Rowland
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Schizophrenia and the Family A Survey of the Literature 1956–1960 on the Etiology of Schizophrenia
Authors: J. Foudraine
Journal: Psychotherapy and Psychosomatics (1961)

Research Articles| February 10 2010 Schizophrenia and the Family A Survey of the Literature 1956–1960 on the Etiology of Schizophrenia Subject Area: Psychiatry and Psychology J. Foudraine J. Foudraine From the Psychiatric University Clinic Wilhelmina Gasthuis Amsterdam (Director: Prof. Dr. L. van der Horst) Search for other works by this author on: This Site PubMed Google Scholar Acta Psychotherapeutica et Psychosomatica (1961) 9 (2-3): 82–110. https://doi.org/10.1159/000285581 Article history Published Online: February 10 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation J. Foudraine; Schizophrenia and the Family A Survey of the Literature 1956–1960 on the Etiology of Schizophrenia. Acta Psychotherapeutica et Psychosomatica 31 December 1961; 9 (2-3): 82–110. https://doi.org/10.1159/000285581 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsActa Psychotherapeutica et Psychosomatica Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1961Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Control by signaling modulators of the sorting of canalicular transporters in rat hepatocyte couplets: Role of the cytoskeleton
Authors: Marcelo G. Roma, Piotr Milkiewicz, Elwyn Elias, Roger Coleman
Journal: Hepatology (2000)

Hormonal control of the restoration of hepatocanalicular polarity in short–term cultured hepatocyte couplets was analyzed. One hour following isolation, couplets were unable to accumulate the fluorescent bile acid analogue, cholyl–lysyl–fluorescein (CLF), and showed a nonpolarized distribution of F–actin and mrp2 over the cell body. A progressive, time–dependent restoration of couplet–polarized function and morphology was reached after 4 hours of culture. Both dibutyryl cyclic adenosine monophosphate (DBcAMP) and the Ca 2+ –elevating compound, thapsigargin, accelerated restoration of normal couplet morphology and function. The DBcAMP–mediated stimulus was inhibited by the Ca 2+ chelator, 1,2– bis –( o –aminophenoxy)–ethene– N , N , N′ , N′ –tetra–acetate tetra–(acetomethyl)ester (BAPTA/AM), but not by the protein kinase A (PKA) inhibitors, KT5720 or H89, suggesting that Ca 2+ elevation rather than PKA activation is involved. N –(6–aminohexyl–5–chloro–1–napththalenesulfonamide (W–7), a calmodulin inhibitor, and the protein kinase C (PKC) activator, phorbol dibutyrate, inhibited both the basal and the DBcAMP–stimulated recovery of functional polarity, whereas staurosporine and Gö 6976, 2 PKC inhibitors, accelerated the basal recovery of polarized function. Disruption of the microtubule cytoskeleton by colchicine induced only minor changes under basal, but not under DBcAMP–stimulated, conditions. The Golgi complex disruptor, brefeldin A, significantly delayed, and the microfilament–disrupting agent, cytochalasin D, fully blocked, both processes. However, DBcAMP stimulated trafficking of vesicles containing CLF to the pericanalicular region under the last condition. Our results indicate that restoration of couplet polarity following isolation occurs via a Ca 2+ –calmodulin–mediated mechanism, which depends on microfilament, but not on microtubule integrity. A second pathway is activated by DBcAMP activation via Ca 2+ –calmodulin formation, whose requirements with respect to cytoskeletal components are opposite. PKC has a negative regulatory role in both pathways.
Age-related Changes in the Acid-secreting Area in Patients with Duodenal Ulcer
Authors: M. Tatsuta, S. Okuda
Journal: Endoscopy (1983)

The extent of, and age-related changes in, the acid-secreting area in patients with duodenal ulcer were compared with those in patients with gastric ulcer and healthy subjects. Studies were made by the endoscopic Congo red test developed in our clinic. The incidence of a large acid-secreting area was significantly higher in patients with duodenal ulcer than in normal subjects or patients with gastric ulcer. Although the incidence of a large acid-secreting area decreased with age in patients with gastric ulcer and in normal subjects, an extensive acid-secreting area was found in patients with duodenal ulcer, irrespective of age. In endoscopic follow-up studies, shrinkage of the acid-secreting area was observed in 18.8% of the healthy subjects and 31.9% of the patients with gastric ulcer, but in only 2.4% of the patients with duodenal ulcer.
Surface expression of FcϵRI on Langerhans' cells of clinically uninvolved skin is associated with disease activity in atopic dermatitis, allergic asthma, and rhinitis
Authors: Amanda E. Semper, Kyle Heron, Alexander C.S. Woollard, Jarema P. Kochan, Peter S. Friedmann, Martin K. Church, Ilona G. Reischl
Journal: Journal of Allergy and Clinical Immunology (2003)
Abstract 561: Tumor-associated fibroblast-induced head and neck squamous cell carcinoma invasion can be abrogated by c-Src and c-Met inhibition
Authors: Huifang Shi, Gouqing He, Sonali Joyce, Sufi M. Thomas
Journal: Cancer Research (2011)

Abstract Purpose: Mortality from head and neck squamous cell carcinoma (HNSCC) is usually associated with locoregional invasion of the tumor into vital organs including the airway. There are currently no treatments that abrogate HNSCC tumor invasion. HNSCC tumors are frequently associated with reactive fibroblasts. Our preliminary data demonstrate that stromal fibroblasts in the vicinity of the tumor induce phosphorylation of c-Src and induce HNSCC invasion. We reported that tumor-associated fibroblasts (TAF) secrete HGF that binds to the c-met receptor on HNSCC activating downstream signaling contributing to the invasive phenotype. In addition we have previously reported that c-Src plays an important role in mediating HNSCC invasion. We hypothesize that blocking c-Met and c-Src in HNSCC cells will abrogate TAF induced HNSCC invasion. Experimental design: Inhibition of c-Met and c-Src was achieved by a combination of small molecule inhibitors and dominant negative approaches. The effect of inhibition of c-Met and c-Src on invasion of HNSCC cells was assessed in an in vitro Matrigel coated transwell invasion assay. Results: We demonstrate that inhibition of c-Met or c-Src with inhibitors or using dominant-negative constructs attenuated TAF-stimulated HNSCC invasion. Combined inhibition of c-Met and c-Src resulted in further attenuation of HNSCC cell invasion in vitro.Conclusions: These cumulative results suggest that TAF-induced signaling through c-Met and c-Src contribute to HNSCC invasion and that targeting these pathways may be a novel strategy to prevent tumor invasion and metastasis in HNSCC. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 561. doi:10.1158/1538-7445.AM2011-561
Selective cyclooxygenase-2 inhibition directly increases human vascular reactivity to norepinephrine during acute inflammation
Authors: N. Foudi, L. Louedec, T. Cachina, C. Brink, X. Norel
Journal: Cardiovascular Research (2008)

The use of cyclooxygenase-2 (COX-2) inhibitors has been reported to be associated with detrimental vascular events. The aim of our study was to evaluate the role of COX-2 activity in the control of human vascular tone under inflammatory conditions. Using organ bath experiments, the contraction induced by norepinephrine (NE), U46619, acetylcholine, and KCl was performed on isolated human internal mammary arteries (IMA) cultured in the presence or absence of both interleukin-1β (IL-1β) and lipopolysaccharide (LPS) with or without endothelium. Under these conditions the COX (cyclooxygenase) isoforms were detected by immunohistochemistry and western blot, and the prostaglandins (PG) and thromboxane (Tx) released were measured using an enzyme immunoassay kit. A significant decrease in the maximal effect induced by NE but not by other stimuli was observed in the IL-1β- and LPS-treated preparations after 6 and 24 h of culture (−19 ± 6 and −25 ± 4%, respectively), an effect that was endothelium independent. Under this inflammatory condition, the COX-2 inhibitors DFU (1 µmol/L), DuP-697 (0.5 µmol/L), and Etoricoxib (1 µmol/L) markedly restored and increased the vascular reactivity to NE. These alterations were not observed with SC-560 (1 µmol/L), a selective COX-1 inhibitor. In addition, the COX-1 isoform was always detected and the COX-2 isoform was only found in human IMA exposed for 6 or 24 h under inflammatory conditions. The COX-2 induction was accompanied by an increase in PGE2 (prostaglandin E2) and PGI2 (prostaglandin I2) release in the culture medium (∼2.5-fold) but not with an increase in TxA2 (thromboxane A2) release. These observations suggest that the inhibition of COX-2 directly potentiates the human vascular tone induced by NE under inflammatory conditions.
The Recurrence Rate of Gestational Diabetes in Subsequent Pregnancies
Authors: Robert G Moses
Journal: Diabetes Care (1996)

To define the recurrence rate of gestational diabetes mellitus (GDM) in a subsequent pregnancy and to determine what factors could be predictive.The subjects of the index pregnancy were 480 personally cared for women with GDM. One hundred women had had a subsequent pregnancy and had been tested for GDM.The recurrence rate of GDM was 35% (95% CI, 25.5-44.5). An increase in weight between the two pregnancies and a higher maternal age and parity were risk associates for a recurrence. A recurrence of GDM was not associated with a higher glucose level, insulin use, or fetal birth weight in the index pregnancy.GDM occurs in only one-third of subsequent pregnancies. Those women who had a recurrence of their GDM were older, more parous, and also had an increase in weight between the pregnancies.
The impaired polymerization of fibrinogen Longmont (Bβ166Arg→Cys) is not improved by removal of disulfide-linked dimers from a mixture of dimers and cysteine-linked monomers
Authors: Karim C. Lounes, Jerry B. Lefkowitz, Agnes H. Henschen-Edman, Andrew I. Coates, Roy R. Hantgan, Susan T. Lord
Journal: Blood (2001)
THE MEASUREMENT OF SEBUM SECRETION TN THE RAT ANGELA
Authors: ANGELA ARCHIBALD, SAM SHUSTER
Journal: British Journal of Dermatology (1970)

SUMMARY.— Surface lipids were removed from anaesthetized rats by dipping them into lipid solvent up to the neck. After varying time intervals, the lipid which had accumulated was removed and assayed gravimetrically. The accumulation of lipid was linearly related to time up until the fourth day, after which it decreased. Passive accumulation from a reservoir of lipid was excluded by the finding that the amount of lipid extracted at 7 successive 4-day intervals did not decrease. The lipid accumulation during the first hours after solvent extraction was too rapid to be accounted for by lipid originating from growth of hair and epidermis. It was concluded that sebum secretion was measured and the rate during the first 4 days was 13·3 ± 0·4 mg./100 G. body weight.
Idiopathic dilated cardiomyopathy exhibits defective vascularization and vessel formation
Authors: Santiago Roura, Francesc Planas, Cristina Prat‐Vidal, Ruben Leta, Carolina Soler‐Botija, Francesc Carreras, Anna Llach, Leif Hove‐Madsen, Guillem Pons Lladó, Jordi Farré, Juan Cinca, Antoni Bayes‐Genis
Journal: European Journal of Heart Failure (2007)