THE USE OF ISOTOPES AS METABOLIC TRACERS
Authors: D STETTEN
Journal: Annals of Internal Medicine (1950)

Article1 January 1950THE USE OF ISOTOPES AS METABOLIC TRACERSDEWITT STETTEN JR.DEWITT STETTEN JR.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-32-1-1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWhen the chemist approaches the study of a biological system, his first enquiry is usually at the analytical level, namely, the identification and quantitative determination of the reactants. Having answered these purely analytical questions, he must next undertake the pursuit of more elusive matters. What reactions do these reactants undergo in the body? How are they formed, and how destroyed? What are the normal rates of these several reactions, and how do these rates vary in response to such variables as growth, disease, drug action and altered nutrition?It is unfortunate that the answers to such questions cannot, in general,...Bibliography1. Knoop F: Der Abbau aromatischer Fettsäuren im Tierkörper, Beitr. z. chem. Physiol. u. Path. 6: 150-162, 1904. Google Scholar2. StettenSchoenheimer DR: Conversion of palmitic acid into stearic and palmitoleic acids in rats, J. Biol. Chem. 133: 329-345, 1940. CrossrefGoogle Scholar3. SchoenheimerRittenberg RD: Deuterium as indicator in study of intermediary metabolism; conversion of stearic acid into palmitic acid in organism, J. Biol. Chem. 120: 155-165, 1937. CrossrefGoogle Scholar4. Stetten D: Biological synthesis of choline by rats on diets with and without adequate lipotropic methyl, J. Biol. Chem. 142: 629-633, 1942. CrossrefGoogle Scholar5. Shemin D: The biological conversion of 1-serine to glycine, J. Biol. Chem. 162: 297-307, 1946. CrossrefMedlineGoogle Scholar6. StettenSchoenheimer MRR: Metabolism of 1(-)-proline studied with aid of deuterium and isotopic nitrogen, J. Biol. Chem. 153: 113-132, 1944. CrossrefGoogle Scholar7. BlochBergRittenberg KBND: Biological conversion of cholesterol to cholic acid, J. Biol. Chem. 149: 511-517, 1943. CrossrefGoogle Scholar8. Bloch K: Biological conversion of cholesterol to pregnandiol, J. Biol. Chem. 157: 661-666, 1945. CrossrefGoogle Scholar9. StettenGrail DGF: Rates of replacement of depot and liver fatty acids in mice, J. Biol. Chem. 148: 509-515, 1943. CrossrefGoogle Scholar10. BernhardBullet KF: Fettstoffwechsel-untersuchungen mit Deuterium als Indicator. II. Beitrag zur Entstehung der Ölsaure aus Kohlenhydraten, Helvet. chim. acta 26: 1185-1189, 1943. CrossrefGoogle Scholar11. StettenBoxer DGE: Studies in carbohydrate metabolism; rate of turnover of liver and carcass glycogen studied with aid of deuterium, J. Biol. Chem. 155: 231-236, 1944. CrossrefGoogle Scholar12. GoldwaterStetten WHD: Studies in fetal metabolism, J. Biol. Chem. 169: 723-738, 1947. CrossrefMedlineGoogle Scholar13. StettenBoxer DGE: Studies in carbohydrate metabolism; metabolic defects in alloxan diabetes, J. Biol. Chem. 156: 271-278, 1944. CrossrefGoogle Scholar14. StettenKlein DBV: Studies in carbohydrate metabolism; effects of hypo- and hyper-insulinism, J. Biol. Chem. 162: 377-382, 1946. CrossrefMedlineGoogle Scholar15. Stetten D: Proc. Am. Diabetes Ass. 69: 1947. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Presented at the Thirtieth Annual Session of the American College of Physicians, New York, N. Y., March 31, 1949. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPast and present concepts of energy metabolism and obesity 1 January 1950Volume 32, Issue 1Page: 1-5KeywordsChemistsDrugsNutritionSystems biology ePublished: 1 December 2008 Issue Published: 1 January 1950 Copyright & PermissionsCopyright, 1950, by The American College of PhysiciansPDF downloadLoading ...