Fish Oil Therapy in Recurrent IgA Nephropathy
Authors: Roland Ng
Journal: Annals of Internal Medicine (2003)

Letters17 June 2003Fish Oil Therapy in Recurrent IgA NephropathyRoland Ng, MDRoland Ng, MDUniversity of Hawaii John A. Burns School of Medicine; Honolulu, HI 96817 (Ng)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-138-12-200306170-00029 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Clinical ObservationsTO THE EDITOR:Background: IgA nephropathy is the most common type of glomerulonephritis worldwide and may lead to kidney failure in approximately 25% of patients (1). Histologic recurrence rates are very high in the transplanted kidney (60%) and, with long-term follow-up, graft loss due to recurrent disease is eventually seen in 30% to 60% of patients (2-4). Because of conflicting trial results, treatment of this disease is controversial, especially the role of omega-3 polyunsaturated fatty acids in the form of fish oil capsules (1).Objective: To describe treatment of post-transplantation IgA nephropathy with fish oil.Case Report: A ...References1. Donadio JV, Grande JP. IgA nephropathy. N Engl J Med. 2002;347:738-48. [PMID: 12213946] CrossrefMedlineGoogle Scholar2. Odum J, Peh CA, Clarkson AR, Bannister KM, Seymour AE, Gillis D, . Recurrent mesangial IgA nephritis following renal transplantation. Nephrol Dial Transplant. 1994;9:309-12. [PMID: 8052439] MedlineGoogle Scholar3. Park SB, Joo I, Suk J, Cho WH, Park CH, Kim SP, . IgA nephropathy in renal transplant recipients: is it a significant cause of allograft failure? Transplant Proc. 1996;28:1540-2. [PMID: 8658777] MedlineGoogle Scholar4. Ohmacht C, Kliem V, Burg M, Nashan B, Schlitt HJ, Brunkhorst R, . Recurrent immunoglobulin A nephropathy after renal transplantation: a significant contributor to graft loss. Transplantation. 1997;64:1493-6. [PMID: 9392321] CrossrefMedlineGoogle Scholar5. Ponticelli C, Traversi L, Feliciani A, Cesana BM, Banfi G, Tarantino A. Kidney transplantation in patients with IgA mesangial glomerulonephritis. Kidney Int. 2001;60:1948-54. [PMID: 11703614] CrossrefMedlineGoogle Scholar6. Kimata N, Tanabe K, Ishikawa N, Ozu H, Sonda K, Yumura W, . Correlation between proteinuria and prognosis of transplant IgA nephropathy. Transplant Proc. 1996;28:1537-9. [PMID: 8658776] MedlineGoogle Scholar7. Donadio JV, Bergstralh EJ, Offord KP, Spencer DC, Holley KE. A controlled trial of fish oil in IgA nephropathy. Mayo Nephrology Collaborative Group. N Engl J Med. 1994;331:1194-9. [PMID: 7935657] CrossrefMedlineGoogle Scholar8. Donadio JV. Omega-3 polyunsaturated fatty acids: a potential new treatment of immune renal disease. Mayo Clin Proc. 1991;66:1018-28. [PMID: 1921484] CrossrefMedlineGoogle Scholar9. Butani L, Palmer J. Effect of fish oil in a patient with post-transplantation IgA nephropathy [Letter]. Nephrol Dial Transplant. 2000;15:1264-5. [PMID: 10910466] CrossrefMedlineGoogle Scholar10. Pozzi C, Bolasco PG, Fogazzi GB, Andrulli S, Altieri P, Ponticelli C, . Corticosteroids in IgA nephropathy: a randomised controlled trial. Lancet. 1999;353:883-7. [PMID: 10093981] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: University of Hawaii John A. Burns School of Medicine; Honolulu, HI 96817 (Ng) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByThe clinical course of IgA nephropathy after kidney transplantation and its managementTreatment protocol with pulse and oral steroids for IgA Nephropathy after kidney transplantationRecurrent and De Novo Renal Diseases After Kidney TransplantationChronic Kidney DiseaseEffects of Fish Oil Supplementation on Kidney Transplantation: A Systematic Review and Meta-Analysis of Randomized, Controlled TrialsDocosahexaenoic Acid Attenuates Mycotoxin-Induced Immunoglobulin A Nephropathy, Interleukin-6 Transcription, and Mitogen-Activated Protein Kinase Phosphorylation in MiceRenal transplantation in patients with IgA mesangial glomerulonephritisFish oil was beneficial in a patient with recurrent post-transplantation IgA nephropathy, 17 June 2003Volume 138, Issue 12Page: 1011KeywordsBiopsyCorticosteroid therapyImmunosuppressivesOilsProgressive diseasesProteinuriaRenal diseasesRenal failureRenal transplantationTransplantation ePublished: 17 June 2003 Issue Published: 17 June 2003 CopyrightCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...