tbuckley/cabot-search huggingface dataset:
Evaluation of a call programme for cervical cytology screening.
Authors: K. J. Shroff
Journal: BMJ (1989)

The questions raised by Dr Cruickshank con- cern achieved blood pressure in individual patients.We obtained a stable reduction in diastolic blood pressure to below 90 mm Hg (treatment target) in 30 of the 41 patients receiving antihypertensive treatment.The following patients had a diastolic blood pressure >90 mm Hg: five of the nine patients with uraemia; two of three patients with myocardial infarction; and four of the 27 patients who survived.These figures indicate that seven of 14 patients who died durirr the studv had a sustained raised blood pressure despite antihypertensive treatment.
Improved screening for colorectal cancer by immunological detection of occult blood
Authors: D J Frommer, A Kapparis, M K Brown
Journal: BMJ (1988)

A radial immunodiffusion technique for detecting faecal haemoglobin and the Hemoccult II kit used with and without rehydration of the faecal sample were compared in a screening programme for bowel cancer, in which 1328 subjects took part. A positive result was obtained in 170 (13%) subjects. Nineteen of the 153 subjects investigated were found to have colorectal carcinomas and 52 had polyps (40 with adenomas). Radial immunodiffusion and Hemoccult II with and without rehydration detected bleeding in, respectively, all 19, 15, and 11 subjects with colorectal carcinoma. Hemoccult II with and without rehydration detected only seven and six, respectively, of 11 Dukes's stage A carcinomas, whereas all 11 were detected with the immunological test. Hemoccult II with and without rehydration and radial immunodiffusion detected bleeding from adenomas in, respectively, 22, 14, and 34 of the 40 subjects. False positive results occurred in 55 out of 1302 subjects by Hemoccult II with rehydration, in 28 out of 1304 by Hemoccult II without rehydration, and in 50 out of 1304 by the immunological technique; true positive results were defined as bleeding from carcinomas and adenomas. Immunological detection of occult blood in faecal samples seems to show more adenomas and carcinomas (particularly early lesions) than the Hemoccult II kit and has a rate of false positive results that is acceptably low.
Laparoscopic Findings in Hereditary Haemorrhagic Telangiectasia (Osler-Weber-Rendu Disease)
Authors: J.A. Solis-Herruzo, J. Garcia-Cabezudo, F. Santalla-Peciña, A. Duran-Aguado, J. Olmedo-Camacho
Journal: Endoscopy (1984)

The laparoscopic findings observed in eight patients with hereditary haemorrhagic telangiectasia are reported. Clinical signs or laboratory data suggestive of liver involvement were present in all cases and constituted the main indication for laparoscopic examination. Characteristic vascular lesions distributed at random were found in four cases. Numerous oval, round or polygonal areas of 0.5 to 1.5 cm in diameter were observed on the external surface of the liver. They were of a reddish or pink colour, flat or slightly raised, and made up of a dense vascular meshwork. In one patient macronodular cirrhosis was associated with the vascular lesions. In the remaining four cases laparoscopic examination did not show striking vascular changes, although the liver biopsy revealed a fatty liver in three cases and micronodular cirrhosis with intense inflammatory activity, steatosis and Mallory bodies in one case. In these cases the accompanying hepatic lesions could probably not be aetiopathogenically related to Osler's disease.
Prosthetics and Reconstruction
Authors: Joe B. Drane
Journal: JAMA (1972)

To the middle-aged school teacher who had recently had her nose removed because of malignant disease, the thought of facing her young charges the next month was a frightening experience. Fortunately, the confrontation never came. A prosethetic nose constructed of a soft plastic and tinted to match the patient's complexion was fabricated in a matter of days prior to school opening. The teacher could now comfortably continue gainful employment and contribute to society while awaiting plastic reconstructive surgery. This is not a hypothetical case. This is one of many cases in our experience at the University of Texas at Houston Dental Branch, and MD Anderson Hospital and Tumor Institute. The maxillofacial prosthetic service, working closely and within the section of head and neck surgery, has rendered valuable aid in the treatment and rehabilitation of patients with head and neck cancer. Approximately 21% of those patients treated for head and neck
Relationship between hematopoietic growth factors levels and hematological parameters in Argentine hemorrhagic fever
Authors: R.F. Marta, D. Enria, F.C. Molinas
Journal: American Journal of Hematology (2000)

Argentine hemorrhagic fever (AHF) is a viral disease caused by Junin virus and characterized by hematologic and neurological involvement. The main hematologic features are leukopenia, thrombocytopenia, and bone marrow hypoplasia. Hematopoietic growth factors serum levels were measured by ELISA technique in forty-eight patients with confirmed diagnosis of AHF. Patients were classified according to the clinical picture in 15 severe (SCF), 17 moderate (MoCF), and 16 mild (MiCF) cases. Erythropoietin levels were decreased in 28 of 45 patients and raised in 4 SCF patients. Twenty-four of 38 patients had high G-CSF levels at admittance in accordance with clinical picture severity, while IL-3, GM-CSF, and TGF-β were normal in most cases. A direct correlation was found between G-CSF and TNF-α levels. Thrombopoietin levels were found to be raised in 19 of 21 patients. In conclusion, the low levels of Epo may contribute to the severe bone marrow erythroblastopenia described in AHF patients, while G-CSF seems to be a marker of illness severity. Am. J. Hematol. 64:1–6, 2000. © 2000 Wiley-Liss, Inc.
Diabetic nephropathy and risk factors for peripheral artery disease in Chinese with type 2 diabetes mellitus
Authors: Ming-Chia Hsieh, Kai-Jen Tien, Daw-Shyong Perng, Jeng-Yueh Hsiao, Shun-Jen Chang, Hui-Ting Liang, Hung-Chun Chen, Shih-Te Tu
Journal: Metabolism (2009)
ANTIBODY FORMATION IN MEN FOLLOWING INJECTION OF FOUR TYPE-SPECIFIC POLYSACCHARIDES OF PNEUMOCOCCUS
Authors: Michael Heidelberger, Colin M. MacLeod, Richard G. Hodges, William G. Bernhard, Marie M. di Lapi
Journal: The Journal of Experimental Medicine (1947)

1. Random selections of the sera of trainees injected 2 months previously with the specific polysaccharides of Types I, II, V, and VII pneumococci contained quantities of antibody to Types I, II, and VII sufficient to account for the favorable results of the immunization procedure. 2. As in earlier studies, the levels of the antibody for the C polysaccharide remained relatively constant before and after the injections. 3. The serum from the preliminary bleedings often contained antibody to the Type VII polysaccharide. This remained relatively constant in a control group injected with saline.
Identification of immunophenotypic signatures by clustering analysis in pediatric patients with Philadelphia chromosome‐positive acute lymphoblastic leukemia
Authors: Barbara Buldini, Andrea Zangrando, Barbara Michielotto, Marinella Veltroni, Emanuela Giarin, Francesca Tosato, Gianni Cazzaniga, Andrea Biondi, Giuseppe Basso
Journal: American Journal of Hematology (2009)

Median 4.42 (range 21.1
Pivotal function for cytoplasmic protein FROUNT in CCR2-mediated monocyte chemotaxis
Authors: Yuya Terashima, Nobuyuki Onai, Masako Murai, Masahiko Enomoto, Vongsakorn Poonpiriya, Tsuyoshi Hamada, Kazushi Motomura, Makiko Suwa, Taichi Ezaki, Tatsuya Haga, Shiro Kanegasaki, Kouji Matsushima
Journal: Nature Immunology (2005)
Comparison of endothelialization and neointimal formation with stents coated with antibodies against CD34 and vascular endothelial-cadherin
Authors: Joo Myung Lee, WonSeok Choe, Baek-Kyung Kim, Won-Woo Seo, Woo-Hyun Lim, Chan-Koo Kang, San Kyeong, Khee Dong Eom, Hyun-Ju Cho, Young-Chan Kim, Jin Hur, Han-Mo Yang, Hyun-Jai Cho, Yoon-Sik Lee, Hyo-Soo Kim
Journal: Biomaterials (2012)
Coexistent mahaim and kent accessory connections: Diagnostic and therapeutic implications
Authors: Joseph A. Abbott, Melvin M. Scheinman, Fred Morady, Edward N. Shen, Ronald Miller, Michael A. Ruder, Michael Eldar, John J. Seger, Jesse C. Davis, Jerry C. Griffin, Lorenzo A. DiCarlo
Journal: Journal of the American College of Cardiology (1987)
Progress in in vitro fertilisation?
Authors: A. E Raffle
Journal: BMJ (1986)

toxic nodules treated with 500 MBq (13-5 mCi) of 1311 and have found no cases of hypothyroidism.Nevertheless, after treatment with a single standard dose of '3'I some patients will remain thyrotoxic and require a second dose to render them permanently euthyroid.We regard this as entirely acceptable when compared with thyroidectomy, which carries a small but well documented complication rate even in expert hands, results in a scar, requires hospital admission, and is very much more expensive than `31I therapy.
Legionella bozemanii and Empyema
Authors: LEE R. BRETTMAN
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 July 1986Legionella bozemanii and EmpyemaLEE R. BRETTMAN, M.D., DEBORAH DEHERTOGH, M.D., ELLIOT L. RANK, PH.D., MONA A. MANDOUR, B.S.LEE R. BRETTMAN, M.D., DEBORAH DEHERTOGH, M.D., ELLIOT L. RANK, PH.D., MONA A. MANDOUR, B.S.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-105-1-146_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Parry and colleagues (1) recently reported five cases of nosocomial pneumonia due to Legionella bozemanii in immunosuppressed patients. We report a case of an empyema due to this organism occurring in a patient with an underlying lymphoma.A 65-year-old man with a 12-year history of non-Hodgkin's lymphoma was hospitalized because of left-sided pleuritic chest pain and fever of 5 days' duration. He denied having headache, abdominal pain, nausea, diarrhea, or difficulty in walking. His medications included chlorambucil and prednisone (for 2 months).Physical examination showed the patient to be chronically ill but alert and oriented. His temperature...References1. PARRYSTAMPLEMANHUTCHINSONFOLTASTEINBERGKRASNOGOR MLJDML. Waterborne Legionella bozemanii and nosocomial pneumonia in immunosuppressed patients. Ann Intern Med. 1985;103:205-10. LinkGoogle Scholar2. MCDADEBRENNERBOZEMAN JDF. Legionnaires' disease bacterium isolated in 1947. Ann Intern Med. 1979;90:659-61. LinkGoogle Scholar3. THOMASONHARRISHICKLINBLACKMONMOSSMATTHEWS BPMJCF. A Legionella-like bacterium related to WIGA in a fatal case of pneumonia. Ann Intern Med. 1979;91:673-6. LinkGoogle Scholar4. CORDESGORMANWILKINSONFIKESFRASER LGHBD. Atypical Legionella-like organisms: fastidious water-associated bacteria pathogenic for man. Lancet. 1979;2:927-30. CrossrefMedlineGoogle Scholar5. FREDDMANCOODLEYJOHNSTONGOODMANKATZ AERLS. Loculated pleural effusion caused by Legionella pneumophila. Thorax. 1982;37:79-80. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Mount Sinai Hospital Hartford, CT 06112 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLegionella pulmonary abscess and pleural space infection in an immunocompetent patientBacterial InfectionsSurgical versus Nonsurgical Treatment of Empyema Thoracis: An Outcomes AnalysisBacterial InfectionsPneumonia due to Legionella bozemanii and Chlamydia psittaci/TWAR following renal transplantationLegionellosisLegionella bozemanii Pneumonia in an Immunocompromised PatientLegionella InfectionsLegionella bozemanii Pneumonia and TetracyclineSERGIO RUIZ-SANTANA, M.D., JOSE M. AGUADO-BOURREY, M.D., JOSE M. NARVAEZ-BERMEJO, M.D., GEMA GONZALEZ-MEDIERO, M.D. 1 July 1986Volume 105, Issue 1Page: 145-146KeywordsDiarrheaFeversHeadachesIschemiaLegionellaLymphomaNauseaPneumoniaTemperatureWalking Issue Published: 1 July 1986 PDF downloadLoading ...
ASSESSMENT OF CYCLIC CHANGES IN THE SIZE OF THE AORTIC ANNULUS USING SPECKLE-TRACKING TRANSESOPHAGEAL ECHOCARDIOGRAPHY
Authors: Hisao Yoshikawa, Makoto Suzuki, Go Hashimoto, Yukiko Kusunose, Takenori Otsuka, Masato Nakamura, Kaoru Sugi
Journal: Journal of the American College of Cardiology (2013)
The new zealand priority criteria project. part 2: coronary artery bypass graft surgery
Authors: D. C Hadorn, A. C Holmes
Journal: BMJ (1997)

<h3>Abstract</h3> Priority criteria developed during a national project were used to conduct an audit of all 662 patients on waiting lists for coronary artery bypass surgery in New Zealand during spring 1996. Based on the observed distribution of priority scores, the cost of providing surgery to all patients down to various levels of priority was estimated. Descriptions incorporating life expectancy and quality of life implications of surgery were developed of the kinds of patients who would or would not receive surgery at each of several possible funding levels. Cardiologists and cardiac surgeons agreed that a threshold of 25 points was a reasonable clinical goal but to work with a threshold of 35, which can be sustained with current levels of funding. All agree that the gap between these clinically preferred and currently afforded thresholds is a subject for wider societal dialogue and decision. The ability to measure the size of the gap between clinical desirability and financial sustainability provides a new transparency to the problem of healthcare resource allocation.
Mannitol and Amphotericin B-Reply
Authors: Jeffrey M. Rosch
Journal: JAMA (1977)

<h3>In Reply.—</h3> We would like to thank Dr Jotkowitz for his interest. The patient's weight was 70 kg. As stated in the article, 25 gm mannitol was added to 17.5 mg amphotericin B and both medications in solution were infused simultaneously. Specifically, amphotericin B powder was diluted with the manufacturer's supplied diluent to a concentration of 5 mg/ml. Then 3.5 ml of this amphotericin solution was added to 125 ml of a 20% mannitol solution, which was then diluted with 5% dextrose in water to 1,000 ml prior to infusion. The final amphotericin B concentration was 0.0175 mg/ml and the mannitol was a 2.5% solution.
Breast screening guidelines should be adapted in Down's syndrome
Authors: D. Satge
Journal: BMJ (2002)

EDITOR—Piachaud and Rohde underlined the importance of including women with learning disabilities in screening programmes because of their reported increase in mortality from cancer, although no case of breast cancer was detected in patients with Down's syndrome.1 Patja et al observed that in Finland breast cancer was nearly as frequent in people with intellectual disabilities as in the general population.2 In the subgroup of 1012 women with Down's syndrome no breast cancer was observed, although 3.9 cases were expected.2

We conducted …
King Tutankhamun, Modern Medical Science, and the Expanding Boundaries of Historical Inquiry
Authors: Howard Markel
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Quantitative Rest Technetium-99m Tetrofosmin Imaging in Predicting Functional Recovery After Revascularization: Comparison With Rest–Redistribution Thallium-201
Authors: Ichiro Matsunari, Susumu Fujino, Junichi Taki, Junji Senma, Takahiko Aoyama, Takanobu Wakasugi, Jun-ichi Hirai, Takashi Saga, Shinichiro Yamamoto, Norihisa Tonami
Journal: Journal of the American College of Cardiology (1997)
Treatment Approaches to Major Depressive Disorder Relapse
Authors: Mark E. Schmidt, Maurizio Fava, Shuyu Zhang, Jill Gonzales, Nancy J. Raute, Rajinder Judge
Journal: Psychotherapy and Psychosomatics (2002)

&lt;i&gt;Objective:&lt;/i&gt; Although continuing antidepressant treatment after patients have responded to medication has been shown to greatly reduce the risk of relapse, this risk is not eliminated. A number of theories have been proposed to account for this apparent loss of efficacy. A common initial approach to managing relapse is to increase the dose of antidepressant. We prospectively evaluated the likelihood of response to increasing the fluoxetine doses in patients relapsing during a long-term efficacy study of two fluoxetine dosing regimens. &lt;i&gt;Method:&lt;/i&gt; Patients meeting the DSM-IV criteria for major depressive disorder with modified HAMD17 scores ≧18 and CGI-severity scores ≧4 were treated for 13 weeks with open-label 20 mg/day fluoxetine in a multicenter US study. Responders (n = 501) were randomized to 20 mg fluoxetine daily, placebo, or 90 mg enteric-coated fluoxetine weekly for 25 weeks of double-blind continuation treatment. If the patients relapsed during the continuation phase, they were offered a 25-week optional rescue treatment phase during which the study medication dose was increased as follows: (1) patients on placebo had treatment with fluoxetine 20 mg/day reinitiated, (2) patients on fluoxetine 20 mg/day had their dose increased to 40 mg/day, and (3) patients on a 90-mg weekly dose had their dose increased to 90 mg twice a week. The results of the rescue phase for the latter two groups who relapsed while on continuation treatment with fluoxetine are reported. Response was defined as a 50% reduction in the modified HAMD17 score since time of relapse and a CGI-severity score ≤2. Additional efficacy analyses included HAMD and CGI-severity changes from baseline to endpoint. Safety measures included assessment of treatment-emergent adverse events, vital signs, and laboratory measures. &lt;i&gt;Results:&lt;/i&gt; Overall, patients relapsing during the continuation treatment responded to an increased dose (57% of the 40-mg-daily group and 72% of the enteric-coated 90-mg-twice-weekly group). Mean modified HAMD17 scores decreased from a mean of approximately 20 to below 8 and were maintained for up to 6 months in the responders. Thirty-five percent of patients either did not respond or initially responded but again relapsed after augmentation of medication. &lt;i&gt;Conclusions:&lt;/i&gt; The patients relapsing after initially responding to fluoxetine can benefit from an increase in fluoxetine dose. These results also generally support increasing dose as a first-line treatment strategy for a patient who has relapsed while taking a previously effective dose of an antidepressant. Increasing enteric-coated fluoxetine 90 mg once weekly to twice weekly appeared to be as well-tolerated and effective in restoring response as increasing a daily fluoxetine dose from 20 to 40 mg.
Impaired microvascular dilatation and capillary rarefaction in young adults with a predisposition to high blood pressure.
Authors: J P Noon, B R Walker, D J Webb, A C Shore, D W Holton, H V Edwards, G C Watt
Journal: Journal of Clinical Investigation (1997)

Increased vascular resistance in essential hypertension occurs mainly in microvessels with luminal diameters < 100 microm. It is not known whether abnormalities in these vessels are a cause or consequence of high blood pressure (BP). We studied 105 men (aged 23-33 yr) in whom predisposition to high blood pressure has been characterized by both their own BP and those of their parents. Factors that are secondary to high BP correlate with offspring BP irrespective of parental BP, but factors that are components of the familial predisposition to high BP are more closely associated with higher BP in offspring whose parents also have high BP. Offspring with high BP whose parents also have high BP had impaired dermal vasodilatation in the forearm following ischemia and heating (289+/-27 [n = 25] versus 529+/-40 [n = 26], 476+/-38 [n = 30], and 539+/-41 flux units [n = 24] in other groups; P < 0.0001) and fewer capillaries on the dorsum of the finger (23+/-0.8 capillaries/0.25 mm2 versus 26+/-0.8 in all other groups; P < 0.003). Except for BP, other hemodynamic indices (including cardiac output and forearm vascular resistance) were not different. The dermal vessels of men who express a familial predisposition to high BP exhibit increased minimum resistance and capillary rarefaction. Defective angiogenesis may be an etiological component in the inheritance of high BP.
Is necropsy a valid monitor of clinical diagnosis performance?
Authors: R Saracci
Journal: BMJ (1991)

OBJECTIVE--To improve the validity of comparisons between clinical and postmortem diagnoses when postmortem diagnosis is used to monitor clinical diagnosis performance. DESIGN--Analysis of elementary examples. MAIN OUTCOME MEASURES--Sensitivity and specificity of clinical and postmortem diagnoses and confirmation and agreement rates. Sensitivity and specificity permit valid comparisons of clinical and postmortem diagnoses among different procedures, sites, or times whereas agreement and confirmation rates may be misleading. Estimates of sensitivity and specificity, however, can be severely distorted by factors such as non-random selection of cases for necropsy or by unrecognised errors in postmortem diagnosis. Such distortion may be minimised by (a) estimating the likely magnitude of errors in postmortem diagnosis, (b) specifying standard conditions for performing necropsies, and (c) ensuring an unbiased sample of moderate size rather than a large biased sample. CONCLUSION--Sensitivity and specificity should be used as measures of agreement between clinical and postmortem diagnoses. IMPLICATION--Monitoring of clinical diagnosis performance by necropsy surveys requires ensuring accuracy of pathological examinations and validity of study design and analysis.