tbuckley/cabot-search huggingface dataset:
Diffuse Alveolar Hemorrhage in Hematopoietic Stem Cell Transplant Recipients
Authors: Bekele Afessa, Ayalew Tefferi, Mark R. Litzow, Michael J. Krowka, Mark E. Wylam, Steve G. Peters
Journal: American Journal of Respiratory and Critical Care Medicine (2002)

Hematopoietic stem cell transplantation (HSCT) is used for the INCIDENCE treatment of hematologic and solid tumors as well as for various The frequency of DAH has varied among reported series bebenign diseases worldwide. The International Bone Marrow cause of differences in patient mix, diagnostic approaches, and Transplant and the Autologous Blood and Marrow Transplant diagnostic criteria. The factors that influence the incidence of Registries estimate that approximately 50,000 hematopoietic DAH have changed over time and varied among HSCT centers. stem cell transplants were performed in 1998. Approximately Although bronchoscopy and surgical lung biopsy have been used 17,000 of these were allogeneic, and over 30,000 were autologous. for decades, their application in HSCT recipients with pulmonary Pulmonary complications develop in 30 to 60% of HSCT recipiinfiltrates has not been well standardized. Because underlying ents (1, 2). Because of graft-versus-host disease and immunosupconditions may prohibit invasive procedures, some clinicians pressant medications, both infectious and noninfectious pulmoprefer to initiate empiric antibiotics for suspected infection leadnary complications are more common in allogeneic than in ing to underdiagnosis of DAH. Moreover, although BAL is autologous HSCT recipients. Compared with bone marrow, the widely used for the diagnosis of DAH, the diagnostic criteria use of peripheral blood as the source of stem cells may lead to have elements of subjectivity and are not uniformly applied. fewer infectious pulmonary complications and bleeding during In seven studies that included 3,806 HSCT recipients, 204 the early post-HSCT period because of its association with a cases of DAH were reported, for a frequency of 5%, with a shorter neutrophil and platelet recovery time (3). The late-onset range between 2% and 14% (8–14). The reported frequency of noninfectious pulmonary complications have been addressed in DAH varies from 1 to 21% in autologous and from 2 to 17% a recent publication (4). Although alveolar hemorrhage can be in allogeneic HSCT recipients (1, 2, 5, 9–12, 15–22). DAH has caused by infections, diffuse alveolar hemorrhage (DAH) is conbeen reported in 123 of 2,616 (5%) autologous and 91 of 1,748 sidered to be a noninfectious pulmonary complication that usu(5%) allogeneic HSCT recipients (1, 2, 5, 9–12, 15–22). The ally occurs in the early posttransplant period. This commentary recent increase in the incidence of DAH has not been associated focuses on the frequency, risk factors, pathogenesis, clinical manwith uses of granulocyte colony-stimulating factor and peripheral ifestation, treatment, and prognosis of DAH. blood stem cell source (10).
Monodispersed Bioactive Glass Submicron Particles and Their Effect on Bone Marrow and Adipose Tissue‐Derived Stem Cells
Authors: Olga Tsigkou, Sheyda Labbaf, Molly M. Stevens, Alexandra E. Porter, Julian R. Jones
Journal: Advanced Healthcare Materials (2013)

Abstract Spherical monodispersed bioactive particles are potential candidates for nanocomposite synthesis or as injectable particles that could be internalized by cells for the local sustained delivery of inorganic therapeutic ions ( e.g., calcium or strontium). Particles are also likely to be released from porous bioactive glass and sol–gel hybrid scaffolds as they degrade; thus, it is vital to investigate their interaction with cells. Spherical monodispersed bioactive glass particles (mono‐SMBG), with diameters of 215 ± 20 nm are synthesized using a modified Stöber process. Confocal and transmission electron microscopy demonstrate that mono‐SMBGs are internalized by human bone marrow (MSCs) and adipose‐derived stem cells (ADSCs) and located within cell vesicles and in the cytoplasm. Particle dissolution inside the cells is observed. Alamar Blue, MTT and Cyquant assays demonstrate that 50 μg mL −1 of mono‐SMBGs did not inhibit significantly MSC or ADSC metabolic activity. However, at higher concentrations (100 and 200 μg mL −1 ) small decrease in metabolic activity and total DNA is observed. Mono‐SMBG did not induce ALPase activity, an early marker of osteogenic differentiation, without osteogenic supplements; however, in their presence osteogenic differentiation is achieved. Additionally, large numbers of particles are internalized by the cells but have little effect on cell behavior.
Clinical features, risk factors, and referral delay in British patients of Indian and European origin with angina matched for age and extent of coronary atheroma.
Authors: N Shaukat, D P de Bono, J K Cruickshank
Journal: BMJ (1993)

Clinical implications* Medical abortion, using mifepristone and gemeprost, is a safe and effective alternative to surgical vacuum aspiration * Up to a third ofthe 200 000 induced abortions performed in Britain each year could be under- taken medically * In this study 20% of women preferred to use medical abortion and 26% vacuum aspiration; the remainder were willing to use either method * Women who prefer to use a particular method should be allowed their choice if acceptability is to be maximised * Women who are unsure which method to use are likely to find vacuum aspiration more accept- able at gestations of over 50 days' amenorrhoea
INFLUENCE OF PRE-TRANSPLANT CHRONIC KIDNEY DISEASE ON OUTCOMES OF ADULT HEART TRANSPLANT-ONLY RECIPIENTS: UNOS REGISTRY ANALYSIS
Authors: Eugene Christopher DePasquale, Richard Cheng, Mrudula Allareddy, Arnold Baas, Martin Cadeiras, Daniel Cruz, Tam Khuu, Ali Nsair, Daniel Jacoby, Mario Deng
Journal: Journal of the American College of Cardiology (2013)
A candidate subspecies discrimination system involving a vomeronasal receptor gene with different alleles fixed in M. m. domesticus and M. m. musculus
Authors: Robert C Karn, Janet M Young, Christina M Laukaitis
Journal: Genome biology (2010)

Assortative mating, a potentially efficient prezygotic reproductive barrier, may prevent loss of genetic potential by avoiding the production of unfit hybrids (i.e., because of hybrid infertility or hybrid breakdown) that occur at regions of secondary contact between incipient species. In the case of the mouse hybrid zone, where two subspecies of Mus musculus (M. m. domesticus and M. m. musculus) meet and exchange genes to a limited extent, assortative mating requires a means of subspecies recognition. We based the work reported here on the hypothesis that, if there is a pheromone sufficiently diverged between M. m. domesticus and M. m. musculus to mediate subspecies recognition, then that process must also require a specific receptor(s), also sufficiently diverged between the subspecies, to receive the signal and elicit an assortative mating response. We studied the mouse V1R genes, which encode a large family of receptors in the vomeronasal organ (VNO), by screening Perlegen SNP data and identified one, Vmn1r67, with 24 fixed SNP differences most of which (15/24) are nonsynonymous nucleotide substitutions between M. m. domesticus and M. m. musculus. We observed substantial linkage disequilibrium (LD) between Vmn1r67 and Abpa27, a mouse salivary androgen-binding protein gene that encodes a proteinaceous pheromone (ABP) capable of mediating assortative mating, perhaps in conjunction with its bound small lipophilic ligand. The LD we observed is likely a case of association rather than residual physical linkage from a very recent selective sweep, because an intervening gene, Vmn1r71, shows significant intra(sub)specific polymorphism but no inter(sub)specific divergence in its nucleotide sequence. We discuss alternative explanations of these observations, for example that Abpa27 and Vmn1r67 are coevolving as signal and receptor to reinforce subspecies hybridization barriers or that the unusually divergent Vmn1r67 allele was not a product of fast positive selection, but was derived from an introgressed allele, possibly from Mus spretus.
Inappropriate Federal Requirements for Air Control in Hospital Isolation Rooms
Authors: Frank S. Rhame
Journal: JAMA (1979)

ON FEB 14, 1947, there appeared in the<i>Federal Register</i>"General Standards" for the construction of hospitals. These standards were created at the request of Congress as part of the implementation of the Hill-Burton program, which provided federal funding for hospital construction. The standards were revised from time to time and in 1973 were retitled "Minimum Requirements of Construction and Equipment for Hospital Medical Facilities." The most recent version<sup>1</sup>was adopted on Oct 3, 1978. It applies to construction of new hospitals and renovation of existing hospitals. Since there is now almost no Hill-Burton money available for hospital construction or renovation, the requirements are used at the federal level only as a criterion for approval of Department of Housing and Urban Development loans to hospitals. However, 17 states have adopted them in their entirety, and most of the remaining states have adopted minimally modified versions.<sup>2(pp2-22)</sup>Although some of
The Miraculous Fever Tree: Malaria, Medicine and the Cure that Changed the World
Authors: O. Mukhtar
Journal: BMJ (2003)

Fiammetta Rocco Harper Collins, £16.99, pp 352 ISBN 0 00257202 8 Rating: ![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img>![Graphic][4]</img> Legend has it that the cure for malaria was discovered in the 17th century by the countess of Cinchona, wife of the viceroy of Peru, when she was revived from a life threatening fever by a dose of bitter Peruvian bark. Learning of her miraculous recovery the people of Lima begged the countess to help them, for they regularly succumbed to the same fever. She ordered that a large quantity of the remedy be distributed among the poor, which … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif [4]: /embed/inline-graphic-4.gif
Rescuing My Grandmothers
Authors: Brendan R. Jackson
Journal: JAMA Internal Medicine (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
<i>In vivo</i> Administration of Artificial Antigen-Presenting Cells Activates Low-Avidity T Cells for Treatment of Cancer
Authors: Stefano Ugel, Alessia Zoso, Carmela De Santo, Yu Li, Ilaria Marigo, Paola Zanovello, Elisa Scarselli, Barbara Cipriani, Mathias Oelke, Jonathan P. Schneck, Vincenzo Bronte
Journal: Cancer Research (2009)

Abstract The development of effective antitumor immune responses is normally constrained by low-avidity, tumor-specific CTLs that are unable to eradicate the tumor. Strategies to rescue antitumor activity of low-avidity melanoma-specific CTLs in vivo may improve immunotherapy efficacy. To boost the in vivo effectiveness of low-avidity CTLs, we immunized mice bearing lung melanoma metastases with artificial antigen-presenting cells (aAPC), made by covalently coupling pepMHC-Ig dimers and B7.1-Ig molecules to magnetic beads. aAPC treatment induced significant tumor reduction in a mouse telomerase antigen system, and complete tumor eradication in a mouse TRP-2 antigen system, when low-avidity CTLs specific for these antigens were adoptively transferred. In addition, in an in vivo treatment model of subcutaneous melanoma, aAPC injection also augmented the activity of adoptively transferred CTLs and significantly delayed tumor growth. In vivo tumor clearance due to aAPC administration correlated with in situ proliferation of the transferred CTL. In vitro studies showed that aAPC effectively stimulated cytokine release, enhanced CTL-mediated lysis, and TCR downregulation in low-avidity CTLs. Therefore, in vivo aAPC administration represents a potentially novel approach to improve cancer immunotherapy. [Cancer Res 2009;69(24):9376–84]
Investigations of the 'active' edge of plaque psoriasis: vascular proliferation precedes changes in epidermal keratin
Authors: M. GOODFIELD, S. MACDONALD HULL, D. HOLLAND, G. ROBERTS, E. WOOD, S. REID, W. CUNLIFFE
Journal: British Journal of Dermatology (1994)

We have investigated markers of epidermal proliferation and differentiation in terms of keratin expression, the morphology of the cutaneous vasculature, and numbers of cutaneous mast cells, in patients with chronic plaque psoriasis. Using the phenomenon of the ‘active edge’, we have studied these features in the psoriatic plaque itself, and in the clinically normal active and inactive edges of the same plaque. Our results confirm the anticipated changes in keratin profiles, mast cell numbers and psoriatic morphology of the vasculature within the plaque itself. They further indicate that the vascular changes precede the epidermal and mast cell features at the active edge, and that the inactive edge is inactive for all of these variables. Mediators responsible for the vascular proliferation and elongation must be present in increased amounts at the active edge when compared with the inactive, and include locally produced and circulating factors.
Second Opinions for Elective Surgery
Authors: Paul M. Gertman, Debra A. Stackpole, Dana Kern Levenson, Barry M. Manuel, Robert J. Brennan, Gary M. Janko
Journal: New England Journal of Medicine (1980)

In 1977, Massachusetts implemented a requirement that Medicaid recipients obtain a second surgical opinion before elective surgery. Using consultants' reports and surveys, we assessed the initial year's results in metropolitan Boston. Of 2060 Medicaid patients originally advised to undergo one of eight elective surgical procedures, 1591 (77.2 per cent) participated in the mandatory second-opinion consultation program, 10.5 per cent received approval for surgery without a second opinion because of clear indications such as cancer, and 12.3 per cent did not keep or accept appointments for a second opinion. Of the 1591 patients who participated, 88.7 per cent were given second opinions in favor of surgery, and 11.3 per cent were advised against surgery. Eight-two of the 180 patients advised not to have surgery sought a third opinion; the negative second opinion was reversed by the third consultant in 57 of these cases (69.5 per cent). Thus, surgery was rejected by a second or third consultant for only 7.7 per cent of the participating patients. We conclude that many negative second opinions are due to honest disagreement about indications for surgery. We also estimate that although the second-opinion program may produce only modest direct savings in Medicaid expenditures, it probably offers important improvements in the quality of health care.
AIDS epidemic in Africa: Epidemic exaggerated
Authors: M. Mattah
Journal: BMJ (1993)

Hypertension guidelines 1B blockers no good for smokers EDITOR,-Though I welcome the British Hyper- tension Society's management guidelines in essential hypertension, I am dismayed that there is no mention of the importance of smoking in the choice of first line antihypertensive drug.'The Medical Research Council's trials in both young and older adults clearly showed that smokers do not benefit from , blockers.23Moreover, the trial in older adults indicated that the excess non- cardiovascular mortality in the treated groups was largely attributable to cancers in the ,B blocker group.3I am not aware of any study of hypertension which has refuted these grave doubts about (B blockade and believe that the rationale for its current use, not restricted to non-smokers, is merely that it lowers blood pressure despite the evidence that smokers would be at least as healthy without the (3blockers and possibly healthier.
A randomized comparison of the nephrotoxicity of iopamidol and diatrizoate in high risk patients undergoing cardiac angiography
Authors: Charles P. Taliercio, Ronald E. Vlietstra, Duane M. Ilstrup, John C. Burnett, Kris K. Menke, Shauna L. Stensrud, David R. Holmes
Journal: Journal of the American College of Cardiology (1991)
Abstract 900: Tissue CA125 expression levels as a biomarker of endometrial cancer
Authors: Shu-Feng Zhou, Shu-Ming He
Journal: Cancer Research (2011)

Abstract Serum CA125 has been recognized as a biomarker of gynecological tumors. However, serum CA125 detection is not very sensitive and specific in the diagnosis of cervical and endometrial carcinoma. This study has investigated the endometrial CA125 expression in patients with endometrial polyps, hyperplasia and carcinoma in comparison with normal endometrium. A total of 242 subjects were recruited into this study and they were classified into six groups, namely proliferative phase endometrium (n = 24), secretory phase endometrium (n = 21), non-functional endometrial polyps (n = 24), simple hyperplasia (n = 24), complex hyperplasia (n = 26), and endometrial carcinoma (n = 126). An immunohistochemistry method was used to detect endometrial CA125 expression. The results showed that there were significant differences in CA125 levels between normal and diseased endometrium, with significantly increased CA125 expression in patients with endometrial polyps, complex hyperplasia, and carcinoma compared to those with normal endometrium. There was only a weak CA125 expression in normal endometrium and simple endometrium hyperplasia. There were significant differences in CA125 expression levels between patients with non-functional endometrial polyps, simple hyperplasia, and complex hyperplasia (χ2 = 9.652, p &amp;lt; 0.005). In endometrial carcinoma group, there was a significant difference in CA125 expression among patients with pathological grade I, II and III of endometrial carcinoma (χ2=11.975, p &amp;lt; 0.01), while there was no significant difference in CA125 expression between grade I and grade II carcinoma (χ2=3.698, p &amp;gt; 0.05). These findings indicate that endometrial CA125 expression can be used as a reliable biomarker in the diagnosis and clinical staging of endometrial carcinoma in Chinese women. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 900. doi:10.1158/1538-7445.AM2011-900
Mono-guanidine heterolipid based SMEDDS: A promising tool for cytosolic delivery of antineoplastics
Authors: Harshad Shete, Sandip Sable, Pritish Tidke, Nilakash Selkar, Yogita Pawar, Avik Chakraborty, Abhijit De, Geeta Vanage, Vandana Patravale
Journal: Biomaterials (2015)
Defective hepatic mitochondrial respiratory chain in patients with nonalcoholic steatohepatitis
Authors: Mercedes Pérez-Carreras, Pilar Del Hoyo, Miguel A. Martín, Juan C. Rubio, Ana Martín, Gregorio Castellano, Francisco Colina, Joaquín Arenas, José A. Solis-Herruzo
Journal: Hepatology (2003)

Mitochondrial dysfunction might play a central role in the pathogenesis of nonalcoholic steatohepatits (NASH). The aims of this study were to evaluate whether free fatty acid (FFA) transport into the mitochondria or the activity of mitochondria respiratory chain (MRC) complexes are impaired in NASH. In patients with NASH and control subjects, we measured free carnitine, short–chain acylcarnitine (SCAC) and long–chain acylcarnitine (LCAC) esters, carnitine palmitoyltransferase (CPT) activity, and MRC enzyme activity in liver tissue as well as serum concentration of tumor necrosis factor α (TNF–α), homeostatic metabolic assessment of insulin resistance (HOMA IR ), and body mass index (BMI). In patients with NASH, the LCAC/free carnitine ratio was significantly increased and the SCAC/free carnitine ratio was decreased. In patients with NASH, the activity of the MRC complexes was decreased to 63% ± 20% (complex I), 58.5% ± 16.7% (complex II), 70.6% ± 10.3% (complex III), 62.5% ± 13% (complex IV), and 42.4% ± 9.1% (adenosine triphosphate synthase) of the corresponding control values. Activity of these complexes correlated significantly with serum TNF–α and HOMA IR . Serum TNF–α (36.3 ± 23.1 pg/mL), HOMA IR (4.5 ± 2.38), and BMI (29.9 ± 3.5 kg/m 2 ) values were significantly increased in patients with NASH. In conclusion, activities of MRC complexes were decreased in liver tissue of patients with NASH. This dysfunction correlated with serum TNF–α, insulin resistance, and BMI values. (Hepatology 2003;38:999-1007).
VEGF-mediated endothelial P-selectin translocation: role of VEGF receptors and endogenous PAF synthesis
Authors: Simon Rollin, Caroline Lemieux, Ricardo Maliba, Judith Favier, Louis R. Villeneuve, Bruce G. Allen, Shay Soker, Nicolas G. Bazan, Yahye Merhi, Martin G. Sirois
Journal: Blood (2004)
A Distribution-Based Multiple Imputation Method for Handling Bivariate Pesticide Data with Values below the Limit of Detection
Authors: Haiying Chen, Sara A. Quandt, Joseph G. Grzywacz, Thomas A. Arcury
Journal: Environmental Health Perspectives (2010)

Environmental and biomedical researchers frequently encounter laboratory data constrained by a lower limit of detection (LOD). Commonly used methods to address these left-censored data, such as simple substitution of a constant for all values < LOD, may bias parameter estimation. In contrast, multiple imputation (MI) methods yield valid and robust parameter estimates and explicit imputed values for variables that can be analyzed as outcomes or predictors.In this article we expand distribution-based MI methods for left-censored data to a bivariate setting, specifically, a longitudinal study with biological measures at two points in time.We have presented the likelihood function for a bivariate normal distribution taking into account values < LOD as well as missing data assumed missing at random, and we use the estimated distributional parameters to impute values < LOD and to generate multiple plausible data sets for analysis by standard statistical methods. We conducted a simulation study to evaluate the sampling properties of the estimators, and we illustrate a practical application using data from the Community Participatory Approach to Measuring Farmworker Pesticide Exposure (PACE3) study to estimate associations between urinary acephate (APE) concentrations (indicating pesticide exposure) at two points in time and self-reported symptoms.Simulation study results demonstrated that imputed and observed values together were consistent with the assumed and estimated underlying distribution. Our analysis of PACE3 data using MI to impute APE values < LOD showed that urinary APE concentration was significantly associated with potential pesticide poisoning symptoms. Results based on simple substitution methods were substantially different from those based on the MI method.The distribution-based MI method is a valid and feasible approach to analyze bivariate data with values < LOD, especially when explicit values for the nondetections are needed. We recommend the use of this approach in environmental and biomedical research.