tbuckley/cabot-search huggingface dataset:
Body mass and probability of pregnancy during assisted reproduction treatment: retrospective study
Authors: J X Wang, M Davies, R J Norman
Journal: BMJ (2000)

Being underweight or overweight has an adverse effect on reproduction.1,2 Overweight women have a higher incidence of menstrual dysfunction and anovulation, possibly because of altered secretion of pulsatile gonadotropin releasing hormone, sex hormone binding globulin, ovarian and adrenal androgen, and luteinising hormone and also because of altered insulin resistance. The prevalence of obesity in infertile women is high, but there is no conclusive evidence that extremes of weight are associated with a low rate of pregnancy in women receiving assisted reproduction treatment. This study examined whether body mass index (weight (kg)/(height (m)2)) is associated with reduced fecundity (the probability of achieving at least one pregnancy during treatment) in women receiving assisted reproduction treatment.
Unabsorbable Carbohydrates and Insulin Need
Authors: ANTHONY R. LEEDS
Journal: Annals of Internal Medicine (1975)

Comments and Correction1 November 1975Unabsorbable Carbohydrates and Insulin NeedANTHONY R. LEEDS, M.D., DAVID J. A. JENKINS, M.D., MIGUEL A. GASSULL, M.D., BERNARD COCHET, M.D., LAWRENCE M. BLENDIS, M.D.ANTHONY R. LEEDS, M.D.Search for more papers by this author, DAVID J. A. JENKINS, M.D.Search for more papers by this author, MIGUEL A. GASSULL, M.D.Search for more papers by this author, BERNARD COCHET, M.D.Search for more papers by this author, LAWRENCE M. BLENDIS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-83-5-740_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We compliment Dr. Douglass on his refreshing approach to the dietary control of two diabetic patients who wished to reduce their insulin therapy (1). While accepting that the effect of the raw food diet in reducing insulin requirements may be due, at least partly, to trapping of otherwise absorbable carbohydrate within intact cellulose cell walls (2), we think that other factors may be important. For example, we have shown that unabsorbable carbohydrate reduces post prandial rises of blood sugar (3).The addition of Guar gum (a storage polysaccharide obtained from the cluster bean,Cyamopsis tetragonoloba) to the...References1. DOUGLASS J: Raw diet and insulin requirements. Ann Intern Med 82:61-62, 1975 LinkGoogle Scholar2. HORWITZSLOWIE DL: Raw diet in diabetes mellitus. Ann Intern Med 82:853-854, 1975 LinkGoogle Scholar3. JENKINSLEEDSGASSULL DAM: Reduction in postprandial glycaemia by guar and pectin. Unpublished Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Medical Research Council Gastroenterology Unit Central Middlesex Hospital London N.W. 10 7 N.S. England PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byType 1 diabetes: dietary modification over 100 years since insulin 1 November 1975Volume 83, Issue 5Page: 740-740KeywordsBlood sugarCarbohydratesCell wallsDietFoodInsulinInsulin-like growth factorsPolysaccharides Issue Published: 1 November 1975 PDF downloadLoading ...
Ethics and Regulatory Complexities for Pragmatic Clinical Trials
Authors: Jeremy Sugarman, Robert M. Califf
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Successful Skin Graft in Patient with Generalized Scleroderma
Authors: Bernard E. Herman
Journal: JAMA (1962)

INDOLENT ULCERS caused by sclerodermatous changes in the skin usually occur on the fingers, toes, knees, or elbows, and infrequently occur elsewhere. As they may be refractory to the usual conservative measures, the following case is presented to illustrate the successful application of a skin graft to an ulcer on the leg of a patient with generalized scleroderma. Search of the literature failed to reveal cases of ulceration due to scleroderma treated successfully by skin grafting.  Report of a Case  This was the third Mount Sinai Hospital admission of a 20-year-old housewife. Her chief complaint was an ulcer adjacent to the right medial malleolus which did not heal in spite of 4 months of intensive therapy in the outpatient clinic. Approximately years before her admission, the diagnosis of scleroderma was made by biopsy at Mount Sinai Hospital. At that time she noticed hardness and stiffness of the skin of her
STUDIES IN EDEMA
Authors: Moyer S. Fleisher, Leo Loeb
Journal: The Journal of Experimental Medicine (1909)

1. Direct measurements of the blood pressure carried out during the intravenous infusion of various solutions into rabbits show that although a relation between the height of blood pressure and secretion of urine may be noted, a direct relation docs not exist between blood pressure and peritoneal transudate and intestinal fluid. 2. Calcium chloride docs not increase the peritoneal transudate by a rise of blood pressure, nor does it decrease the intestinal fluid by a fall of blood pressure, since no such increase of peritoneal fluid nor decrease of intestinal fluid is noticeable in animals with myocarditic lesions which are infused with solutions of sodium chloride. 3. It can be proved that calcium chloride does not diminish the amount of urine as a result of its depressing action on the blood pressure. Our experiments make it probable that calcium chloride decreases the diuresis by a direct action on the renal epithelium.
ABC of clinical electrocardiography: Conditions affecting the left side of the heart
Authors: J. Edhouse
Journal: BMJ (2002)

Many cardiac and systemic illnesses can affect the left side of the heart. After a careful history and examination, electrocardiography and chest radiography are first line investigations. Electrocardiography can provide supportive evidence for conditions such as aortic stenosis, hypertension, and mitral stenosis. Recognition of the associated electrocardiographic abnormalities is important as misinterpretation may lead to diagnostic error. This article describes the electrocardiographic changes associated with left atrial hypertrophy, left ventricular hypertrophy, valvular disease, and cardiomyopathies.

#### Conditions affecting left side of heart covered in this article

#### Left ventricular hypertrophy

##### Voltage criteria

###### Limb leads

###### Precordial leads

##### Non-voltage criteria

The specificity of these criteria is age and sex dependent

The term left atrial abnormality is used to imply the presence of atrial hypertrophy or dilatation, or both. Left atrial depolarisation contributes to the middle and terminal portions of the P wave. The changes of left atrial hypertrophy are therefore seen in the late portion of the P wave. In addition, left atrial depolarisation may be delayed, which may prolong the duration of the P wave.



Biphasic P wave in V1. The large negative deflection indicates left atrial abnormality (enlarged to show detail)



The P wave in lead V1 is often biphasic. Early right atrial forces are directed anteriorly giving rise to an initial positive deflection; these …
T-cell independent, B-cell receptor-mediated induction of telomerase activity differs among IGHV mutation-based subgroups of chronic lymphocytic leukemia patients
Authors: Rajendra N. Damle, Sonal Temburni, Taraneh Banapour, Santanu Paul, Patricia K. A. Mongini, Steven L. Allen, Jonathan E. Kolitz, Kanti R. Rai, Nicholas Chiorazzi
Journal: Blood (2012)
STUDIES BASED ON A MALIGNANT TUMOR OF THE RABBIT
Authors: Wade H. Brown, Louise Pearce
Journal: The Journal of Experimental Medicine (1923)

A malignant tumor which developed at the site of a primary syphilitic lesion in the scrotum of a rabbit, about 4 years after inoculation, and eventually led to the death of the animal, has formed the basis for an extensive series of investigations beginning with the study of the spontaneous tumor. The present report contains the clinical history of the animal from the time of inoculation to its death and the results of pathological examinations. The most important events recorded may be summarized as follows: 1. A mild but persistent syphilitic infection with an occasional relapse and the eventual development of chronic inflammatory lesions in the skin associated with atypical epithelial proliferations. 2. The occurrence, at about the same time, of extensive degenerative changes in the dermis accompanied by an atypical growth of hair follicles, with the production of diffuse and nodular areas of thickening and induration (scleroderma). 3. The development of a growth in the skin of the left scrotum which recurred after removal and spread diffusely over adjacent parts of the skin, and metastasized to the regional lymph nodes and to internal organs. 4. The transplantation of the growth to other rabbits by intratesticular inoculation and the successful propagation of the growth over a period of nearly 2 years (twenty generations). 5. The development of a cachexia and of pressure phenomena from metastases involving the cervical and lumbar regions of the spinal column which eventually led to the death of the animal. 6. The discovery, post mortem, of an extensive leucoplakia of the tongue and buccal mucosa, chronic inflammatory lesions in the esophagus with atypical epithelial proliferation, and a nodular growth in the left testicle differing in character from that in the scrotum. 7. The presence of extensive degenerative changes in the vascular system, degeneration of the parenchymatous organs, atrophy of the thymus and lymphoid system, with chronic lymphadenitis, atrophy, degeneration, and necrosis of the suprarenals, and atrophy and hyperplasia of the thyroid with chronic thyroiditis. The conclusion was reached that the growth in the scrotum represented a neoplasm of epithelial origin which was composed of cells allied to those found in the bulb and root sheath of the hair. No explanation was offered for the origin or unusual malignancy displayed by the tumor pending the introduction of experimental data. It was stated, however, that the evidence presented was sufficient to warrant the assumption that the factor of foremost importance in the development of the tumor was constitutional rather than local.
Cost Analysis From Two Randomized Trials of Sirolimus-Eluting Stents Versus Paclitaxel-Eluting Stents in High-Risk Patients With Coronary Artery Disease
Authors: Shpend Elezi, Alban Dibra, Ulrike Folkerts, Julinda Mehilli, Sylvia Heigl, Albert Schömig, Adnan Kastrati
Journal: Journal of the American College of Cardiology (2006)
France may ban part time work on nuclear sites
Authors: A. Dorozynski
Journal: BMJ (1997)

The French government may forbid the employment of casual workers in areas where they may be exposed to high amounts of ionising radiation.

More then 3000 people would be affected by the ban. Most of them are casually employed for maintenance work when power generating reactors are stopped for reloading. Others have job assignments at the Cogema waste processing plants or in military installations. Many of them are allegedly hired–or refused work–on the basis of cumulated doses received during previous …
Depression, Smoking, and Health Status
Authors: Stephen J. Jay
Journal: Annals of Internal Medicine (1997)

Letters15 December 1997Depression, Smoking, and Health StatusStephen J. Jay, MDStephen J. Jay, MDIndiana University School of Medicine; Indianapolis, IN 46202-5114Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-12-199712150-00025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Covinsky and colleagues [1] investigated the relation between symptoms of depression and health status outcomes in hospitalized older patients. They found that symptoms of depression were associated with worse health status on admission, discharge, and follow-up. These associations persisted after adjustment for potential confounding factors, including demographic factors, comorbid conditions, and severity of illness. The authors concluded that the poor functional outcomes seen in patients with more symptoms of depression were not caused by worse health status on admission or more severe physiologic illness but by some “probably complex and reciprocal” relation between symptoms of depression and ...References1. Covinsky KE, Fortinsky RH, Palmer RM, Kresevic DM, Landefeld CS. Relation between symptoms of depression and health status outcomes in acutely ill hospitalized older persons. Ann Intern Med. 1997; 126:417-25. Google Scholar2. LaCroix AZ, Lang J, Scherr P, Wallace RB, Cornoni-Huntly J, Berkman L, et al. Smoking and mortality among older men and women in three communities. N Engl J Med. 1991; 324:1619-25. Google Scholar3. The health benefits of smoking cessation: a report of the Surgeon General. DHHS publication no. 90-8416. Bethesda, MD: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, Centers for Chronic Disease Prevention and Health Promotion, Office on smoking and Health; 1990. Google Scholar4. Fiore MC, Bailey WC, Cohen SJ, et al. Smoking Cessation: Clinical Practice Guideline No. 18 Rockville, MD: U.S. Department of Health and Human Services, Public Health Service, Agency for Health Care Policy and Research; 1996. Google Scholar5. Rimer BK, Orleans CT. Older smokers. In: Orleans CT, Slade J, eds. Nicotine Addiction: Principles and Management. New York: Oxford Univ Pr; 1993; 339-49. Google Scholar Author, Article, and Disclosure InformationAffiliations: Indiana University School of Medicine; Indianapolis, IN 46202-5114 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 December 1997Volume 127, Issue 12Page: 1131KeywordsDepressionElderlyExerciseForecastingHealth care utilizationMedical risk factorsMood disordersNicotineSmoking cessation Issue Published: 15 December 1997 CopyrightCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Prevention of pregnancy after excision of malignant melanoma
Authors: H. S. Goldsmith
Journal: JAMA (1973)

Advice on the kind of contraception to prescribe for a 27-year-old woman gravida 3 para 3 who had had a malignant melanoma of more than 3 years duration excised following her last pregnancy is presented.  The excisional biopsy .5 cm is size revealed normal surrounding skin and nodes were considered uninvolved.  The patient was against sterilization for herself.  A surgeon and an obstetrician-gynecologist respond.  Survival rates of women with malignant melanoma are unaffected by pregnancy.  However a suspected estrogen-dependent neoplasm is contraindication for oral contraceptives.  Vasectomy of the husband was suggested by both consultants.  Otherwise the gynecologist suggested an IUD plus a vaginal spermicidal foam.  The patients husband chose a vasectomy.
A piece of my mind. The intern's vein
Authors: J. Smoller
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The undifferentiated malignant neoplasm. Identification of lymphoma arising in skeletal muscle by immunohistochemical analysis
Authors: Alan R. Berg, James Linder, Ronald W. Anderson, Margaret A. Tempero, James A. Edney, James O. Armitage
Journal: JAMA (1985)

The undifferentiated malignant neoplasm presents a significant problem in the intelligent selection of therapy. Because of advances in chemotherapy, there are cancers that are effectively palliated, and sometimes cured if appropriately treated. Characterization of tumors by immunohistochemical stains drastically reduces the incidence of "undifferentiated" diagnoses and will optimize patient management, as illustrated by two cases of large-cell lymphoma arising in skeletal muscle.
What the white paper might mean for public health
Authors: A. Kessel, A. Haines
Journal: BMJ (2010)

This coming winter, in the wake of the newly laid out plans for the NHS, the UK government will publish a white paper on public health.1 2 We are promised a new Public Health Service for England, and there is a real sense of anticipation in the public health world—though tempered by anxiety about upcoming public sector changes, suggestions of an influential role for the private sector in shaping public health policy, and the current economic climate.3 4 So, what might the new service look like?

For some years local public health teams have been based in primary care trusts. It seems that these teams will move into local authorities, although at what tier remains to be decided. Director of public health posts have already been moving in this direction through joint appointments with local authorities, although their teams have not necessarily followed. Aligning the directors with their departments would therefore seem sensible. This also provides a chance to even out some of the inequities in public health skills and resources that have developed between localities.

A further advantage of placing public health directors and their teams in the council architecture is the closer relationship with those involved in the distal determinants of health—for example, environmental health, housing, …
Expression of betaine transporter mRNA: Its unique localization and rapid regulation in rat kidney
Authors: Akiko Miyai, Atsushi Yamauchi, Toshiki Moriyama, Tetsuya Kaneko, Masaru Takenaka, Toshihiro Sugiura, Hiroshi Kitamura, Akio Ando, Masaya Tohyama, Shoichi Shimada, Enyu Imai, Takenobu Kamada
Journal: Kidney International (1996)
Arsenic trioxide improves event-free and overall survival for adults with acute promyelocytic leukemia: North American Leukemia Intergroup Study C9710
Authors: Bayard L. Powell, Barry Moser, Wendy Stock, Robert E. Gallagher, Cheryl L. Willman, Richard M. Stone, Jacob M. Rowe, Steven Coutre, James H. Feusner, John Gregory, Stephen Couban, Frederick R. Appelbaum, Martin S. Tallman, Richard A. Larson
Journal: Blood (2010)
The Male Menopause: Restoring Vitality and Virility
Authors: M. E Weksler
Journal: BMJ (1996)

Malcolm Carruthers Thorsons, £12.99, pp 240 ISBN 0 722 53208 3

In this book Dr Malcolm Carruthers argues that many men lose energy, drive, and potency between 30 and 80 years of age after the andropause and that their symptoms can be reversed by testosterone hormone replacement therapy. He also claims a conspiracy of silence about “the male menopause” in the medical profession and sees fellow conspirators in the agrochemical industry, which floods the environment with xeno-oestrogens; in the fashion industry, which manufactures tight underwear and jeans which raise testicular temperature; and in politics, where legislators are unwilling to pay for “his as well as her HRT.”

Dr Carruthers, described as a consultant andrologist with a Harley Street clinic, bases his …
Yttrium-90 therapy and 99MTc pertechnetate knee uptake measurements in the management of rheumatoid arthritis.
Authors: V Kyle, B L Hazleman, E P Wraight
Journal: Annals of the Rheumatic Diseases (1983)

Twenty-eight knees with chronic arthritis and effusion were treated with intra-articular 90Y. Synovial activity was assessed by measuring 99mTc pertechnetate uptake. There was a significant difference in uptake between controls and patients. Those who had a good response to 90Y (15 patients) showed a significant decrease in uptake, not seen in those who failed to respond. The pattern of 90Y distribution was examined and appeared to correspond to areas of increased synovial activity; these patterns and their significance have not been previously reported. Factors which could help to predict response to 90Y are discussed.