tbuckley/cabot-search huggingface dataset:
In defence of the NHS: why writing to the House of Lords was necessary
Authors: M. McKee, A. M. Pollock, A. Clarke, D. McCoy, J. Middleton, R. Raine, A. Scott-Samuel
Journal: BMJ (2011)

Last week more than 400 public health doctors, specialists, and academics from across the country wrote an open letter to the House of Lords stating that the Health and Social Care Bill will do "irreparable harm to the NHS, to individual patients, and to society as a whole," that it will "erode the NHS's ethical and cooperative foundations," and that it will "not deliver efficiency, quality, fairness, or choice."1The prime minister claimed that the letter actually supported aspects of the bill, while the
Adherence of heart failure patients to exercise: barriers and possible solutions
Authors: Viviane M. Conraads, Christi Deaton, Ewa Piotrowicz, Nuria Santaularia, Stephanie Tierney, Massimo F. Piepoli, Burkert Pieske, Jean‐Paul Schmid, Kenneth Dickstein, Piotr P. Ponikowski, Tiny Jaarsma
Journal: European Journal of Heart Failure (2012)
PROBLEMS AND DUTIES IN RELATION TO MALARIA.
Authors: WILLIAM KRAUSS
Journal: JAMA (1907)

While doing such missionary work as I have been able on the subject of fevers, I have frequently heard the argument that with the eradication of malaria the medical profession in the country districts would be, like Othello, without an occupation. I do not charge any member of the profession with such narrowness and fallacious logic; I think rather, that we have been slow in taking hold of the prophylaxis of malaria chiefly because it involved unsolved problems and not because we thought it would injure our business. The business of practicing medicine depends for its success on the prosperity of the community and no sickly community can be expected to prosper. Medical orators are wont to tell us that we belong to the only profession whose disciples labor to their own undoing in promoting public health work, but here are the facts; Some of the patients who come to
Efficacy of olanzapine in the treatment of psychogenic excoriation
Authors: J. Blanch, F. Grimalt, G. Massana, V. Navarro
Journal: British Journal of Dermatology (2004)

Journal Article Efficacy of olanzapine in the treatment of psychogenic excoriation Get access J. Blanch, J. Blanch Clinical Institute of Psychiatry and Psychology, Hospital Clínic Universitari de Barcelona, Villarroel 170, 08036 Barcelona, and *Department of Dermatology, Universitat de Barcelona, Barcelona, Spain E‐mail: jblanch@clinic.ub.es Search for other works by this author on: Oxford Academic Google Scholar F. Grimalt, F. Grimalt Clinical Institute of Psychiatry and Psychology, Hospital Clínic Universitari de Barcelona, Villarroel 170, 08036 Barcelona, and *Department of Dermatology, Universitat de Barcelona, Barcelona, Spain E‐mail: jblanch@clinic.ub.es Search for other works by this author on: Oxford Academic Google Scholar G. Massana, G. Massana Clinical Institute of Psychiatry and Psychology, Hospital Clínic Universitari de Barcelona, Villarroel 170, 08036 Barcelona, and *Department of Dermatology, Universitat de Barcelona, Barcelona, Spain E‐mail: jblanch@clinic.ub.es Search for other works by this author on: Oxford Academic Google Scholar V. Navarro V. Navarro Clinical Institute of Psychiatry and Psychology, Hospital Clínic Universitari de Barcelona, Villarroel 170, 08036 Barcelona, and *Department of Dermatology, Universitat de Barcelona, Barcelona, Spain E‐mail: jblanch@clinic.ub.es Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 151, Issue 3, 1 September 2004, Pages 714–716, https://doi.org/10.1111/j.1365-2133.2004.06151.x Published: 01 September 2004
Impact of the NHS reforms on English hospital productivity: an analysis of the first three years
Authors: N. Soderlund, I. Csaba, A. Gray, R. Milne, J. Raftery
Journal: BMJ (1997)

<h3>Abstract</h3> <b>Objectives:</b> To evaluate the effect of purchaser mix, market competition, and trust status on hospital productivity within the NHS internal market. <b>Methods:</b> Hospital cost and activity data were taken from routinely collected data for acute NHS hospitals in England for 1991–2 to 1993-4. Cross sectional and longitudinal regression methods were used to estimate the effect of trust status, competition, and purchaser mix on average hospital costs per inpatient, after adjusting for outpatient activity levels, casemix, teaching activity, regional salary variation, hospital size, scale of activity, and scope of cases treated. <b>Results:</b> Real productivity gains were apparent across the study period for NHS hospitals on average. Casemix adjustment drastically improved cross sectional comparisons between hospitals. Gaining trust status and increasing host district purchaser share were associated with productivity increases after adjustment for casemix, regional salary differences, and hospital size and scope. Hospitals that became trusts during the study period were on average less productive at the beginning of the period than those that did not, and there were no significant productivity differences between trust waves at the end of the period in 1993-4. Market concentration was not associated with productivity differences. <b>Conclusion:</b> Further analysis is needed to determine whether overall and trust associated productivity gains are transient effects, one off shifts, or self perpetuating reorientations of organisational behaviour. Hospitals may have chosen to become trusts because they anticipated being able to increase productivity. Increases in the proportions of small purchasers were associated with increasing costs. Importantly, this study could not adjust for changes in the quality of care. <h3>Key messages</h3> Comparisons of performance between hospitals should take casemix into account, as failure to do so could significantly bias results Gaining independent trust status was associated with significant productivity gains for NHS hospitals, although some of the effect may have been due to self selection; and at the end of the study period productivity differences between trust waves were non-significant Competition between hospitals had no significant effect on productivity during the first three years of the internal market Hospitals that contract with many smaller purchasers other than their host district are more costly, other factors being equal
Indochinese Refugees and Infectious Disease
Authors: RICHARD A. GOODMAN
Journal: Annals of Internal Medicine (1980)

Letters and Corrections1 August 1980Indochinese Refugees and Infectious DiseaseRICHARD A. GOODMAN, M.D., TIMOTHY J. DONDERO JR., M.D., MYRON G. SCHULTZ, D.V.M., M.D., JOSEPH F. GIORDANO, DONALD R. HOPKINS, M.D.RICHARD A. GOODMAN, M.D.Search for more papers by this author, TIMOTHY J. DONDERO JR., M.D.Search for more papers by this author, MYRON G. SCHULTZ, D.V.M., M.D.Search for more papers by this author, JOSEPH F. GIORDANOSearch for more papers by this author, DONALD R. HOPKINS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-93-2-375_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Certain issues raised in the Bay Area Medical Volunteers' letter on the health of Indochinese refugees (1) should be clarified. One of their major concerns is the prevalence of certain conditions among the refugees: acute illnesses, particularly fever and pneumonia; hepatitis B-antigenemia; malaria; and tuberculosis [discussed in the letter below]. They suggest that the prevalences of these problems call for a program for the systematic screening of refugees at the U.S. ports of entry.Pertinent to the question of the prevalence of acute illnesses among the refugees are data collected by the Center for Disease Control (CDC)....References1. ADUANMCCUTCHEONEITZSANGER RMMP. Refugees from Indochina. Ann Intern Med. 1980;92:266. Letter. LinkGoogle Scholar2. . Hepatitis B screening of Indochinese refugees. Can Dis Weekly Rep. 1980;6:14, 15, 18, 19. Google Scholar3. . Health status of Indochinese refugees: malaria and hepatitis B. Morbid Mortal Weekly Rep. 1979;28:463-4, 469-70. Google Scholar4. . Health status of Indochinese refugees. Morbid Mortal Weekly Rep. 1980;28:385-90, 395-8. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: RICHARD A. GOODMAN, M.D.; TIMOTHY J. DONDEROJR., M.D.; MYRON G. SCHULTZ, D.V.M., M.D.; JOSEPH F. GIORDANO; DONALD R. HOPKINS, M.D.Affiliations: Center for Disease Control Atlanta, GA 30333 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byChanging health beliefs and behaviors of resettled Laotian refugees: Ethnic variation in adaptation 1 August 1980Volume 93, Issue 2Page: 375-375KeywordsFeversHepatitisInfectious diseasesMalariaPneumonia ePublished: 1 December 2008 Issue Published: 1 August 1980 PDF downloadLoading ...
The effects of VEGF-R1 and VEGF-R2 ligands on angiogenic responses and left ventricular function in mice
Authors: Jenni Huusko, Mari Merentie, Marike H. Dijkstra, Minttu-Maria Ryhänen, Henna Karvinen, Tuomas T. Rissanen, Maarten Vanwildemeersch, Marja Hedman, Jukka Lipponen, Suvi E. Heinonen, Ulf Eriksson, Masabumi Shibuya, Seppo Ylä-Herttuala
Journal: Cardiovascular Research (2009)

Vascular endothelial growth factors (VEGFs) and their receptors (VEGF-Rs) are among the most powerful factors regulating vascular growth. However, it has remained unknown whether stimulation of VEGF-R1, VEGF-R2 or both of the receptors produces the best angiogenic responses in myocardium. The aim of this study was to compare the VEGF-R1-specific ligand VEGF-B186, VEGF-R2-specific ligand VEGF-E and VEGF-A165, which stimulates both receptors, regarding their effects on angiogenesis and left ventricular function in mice. High-resolution echocardiography was used to guide the closed-chest injections of adenoviral (Ad) vectors expressing VEGF-B186, VEGF-E, and VEGF-A165 into the anterior wall of the left ventricle in C57Bl/6J mice. Angiogenic and functional effects were analysed using histology, ultrasound and perfusion analyses 6 (D6) and 14 (D14) days after the Ad injection. AdVEGF-A165 induced a strong angiogenic response seen as an enlargement of myocardial capillaries whereas angiogenesis induced by AdVEGF-B186 and AdVEGF-E seemed more physiological. The increase in the capillary area was accompanied with an increase in myocardial perfusion at D6 after the gene injection. AdVEGF-A165 and AdVEGF-E induced endothelial-specific proliferation whereas AdVEGF-B186 mostly induced proliferation of cardiomyocytes. AdVEGF-A165 induced more pronounced tissue damage than AdVEGF-B186 and AdVEGF-E. Left ventricular function measured as ejection fraction did not change during the follow-up. AdVEGF-A165 increased both VEGF-R1 and VEGF-R2 protein expression whereas AdVEGF-B186 and AdVEGF-E did not affect endogenous receptor expression levels. AdVEGF-B186 and AdVEGF-E are equally potent in inducing therapeutic angiogenesis in mouse myocardium and produce less side effects than AdVEGF-A165.
Authors' reply to McGregor and Foley
Authors: E. Flint, S. Cummins, A. Sacker
Journal: BMJ (2014)

McGregor and Foley draw attention to the design of our study on mode of commuting and body composition. 1-3We concur with their comments that cross sectional data do not allow causal inference, but previous studies using quasi-experimental study designs have provided indirect evidence that active and public transport uptake is associated with improvements in body mass index. 4Further research is, however, required to unpick causal processes and mechanisms.
Pathogenesis of Bacterial Endocarditis
Authors: Alfred A. Angrist
Journal: JAMA (1963)

SEVERAL ENIGMAS about the mechanism of valvular endocarditis still exist. Why such an entity prevails at all requires elucidation. The relation of vegetations on the valve to an underlying interstitial valvulitis and of the bacterial to the nonbacterial vegetation is still moot. Do the bacteria reach the valve via the interstitial capillary bed or as a deposit directly upon the surface of the valve? No experimental technique has yet reproduced the human forms of chronic distorting valvulitis, as in mitral stenosis. Bacterial endocarditis has been produced experimentally but by procedures which do not even mimic the conditions existing in the human.  The following concept is presented for the origin of bacterial endocarditis. An underlying, prior, interstitial, edematous, and cellular valvular distortion occurs initially. This alteration in the valve substance is accompanied in localized areas of the valve by platelet vegetations, with and without fibrin and occasionally with collagen alteration and
Strategy and Tactics in Research
Authors: F. M. R. Walshe
Journal: BMJ (1943)

Of the various fields of medical activity now coming under review in the discussions being held on the future of medi- cine in this country, that of research must command its full share of attention.If the greatest possible advance- ment of knowledge is to be secured, those in whose hands the reorganization of medicine will lie need a sound concep- tion of all that is embodied in the idea and in the execution of research.We may not assume that everyone eager to provide us with a bright new medical world has the ex- perience or insight necessary to deal with the problems of medical research, nor even that all of those actually engaged in it are endowed with the clearest vision on the subject.Some familiarity with the literature in which original in- vestigations in my own field of medicine are recorded, various discussions that I have listened to, and schemes of research upon particular problems that I have known pro- pounded have led me to believe that not a few of those who engage in research work, or who find themselvesoften for quite irrelevant reasons-in a position to initiate and control it, have extremely limited views as to what constitutes good research, how to plan and set about it, or how to interpret and use tp the best advantage the results it yields.The present time therefore seems apt for an attempt to formulate some general principles of a strategy and tactics of research.I shall concern myself principally with medical research, but my remarks may possibly have a wider application if they are well founded.Research in the Past Until comparatively recent times medical research has been pursued largely in the voluntary hospitals and their medical schools.Most of those from whose ranks the original workers were mainly-recruited-namely, the honorary medical staffs- have from the nature of the voluntary hospital system been compelled to gain their livelihood by the private practice of medicine.As a result clinical research has been hampered in its full development, for those engaged in it have found themselves increasingly drawn away by the demands of practice, until in middle life most of them are compelled to relinquishall hope of serious original work.Even under conditions so adverse, their achievements in the past have been considerable, and have'provided the foundations upon which a more for- tunately placed younger generation may now build.Perhaps not all ofAthis generation realize fully that some at least of the broad perspectives now opening before them they enjoy because they are, as it were, standing on the shoulders of their unsubsidized predecessors.Some of them, it may fairly be urged, are inclined to scorn the base degrees by which they did ascend, and therefore a tribute to the labours of past * Being a paper read before
Up-regulation of the inducible nitric oxide synthase expression in human hepatocytes by the non-structural 5A protein of the hepatitis C virus
Authors: P.L. Majano, M. Gomez, A. Apolinario, M. Lopez-Cabrera, O. Nunez, L. Santos, M. Salcedo, A. Matilla, D. Rincon, G. Clemente, C. Garcia-Monzon
Journal: Journal of Hepatology (2003)
Genotype-Based Methods for Anticipating Gemcitabine-Related Severe Toxicities May Lead to False-Negative Results
Authors: Cédric Mercier, Alexandre Evrard, Joseph Ciccolini
Journal: Journal of Clinical Oncology (2007)

investigated the effects of cytidine deaminase (CDA)geneticpolymorphismsongemcitabinetoxicitiesandalteredpharma-cokinetics. They conclude, from the observation of a single Japanesepatientwiththenonsynonimousmutation208G A(Ala70Thr)anddisplaying an abnormal gemcitabine pharmacokinetic proﬁle result-inginsubsequentneutropenia,thathaplotype*3harboringthe208GmorethanAsinglenucleotidepolymorphism(SNP)couldbeassoci-atedwiththeoccurrenceofseveretoxicitiesaftergemcitabineadmin-istration, and possibly, in combination with other chemotherapyregimens.Suchapatientwithseveretoxicitieswasactually,repeatedlyselectedoutofagroupofﬁve,
Specific targeting of hepatitis C virus core protein by an intracellular single-chain antibody of human origin
Authors: Juliane Karthe, Kathi Tessmann, Jisu Li, Raiki Machida, Maaike Daleman, Dieter Häussinger, Tobias Heintges
Journal: Hepatology (2008)

Abstract The hepatitis C virus (HCV) core protein is essential for viral genome encapsidation and plays an important role in steatosis, immune evasion, and hepatocellular carcinoma. It may thus represent a promising therapeutic target to interfere with the HCV life-cycle and related pathogenesis. In this study, we used phage display to generate single-chain variable domain antibody fragments (scFv) to the core protein from bone marrow plasma cells of patients with chronic hepatitis C. An antibody with high-affinity binding (scFv42C) was thus identified, and the binding site was mapped to the PLXG motif (residues 84-87) of the core protein conserved among different genotypes. Whereas scFv42C displayed diffuse cytoplasmic fluorescence when expressed alone in the Huh7 human hepatoma cell line, cotransfection with the core gene shifted its subcellular distribution into that of core protein. The intracellular association of scFv42C with its target core protein was independently demonstrated by the fluorescence resonance energy transfer technique. Interestingly, expression of the single-chain antibody reduced core protein levels intracellularly, particularly in the context of full HCV replication. Moreover, cell proliferation as induced by the core protein could be reversed by scFv4C coexpression. Therefore, scFv42C may represent a novel anti-HCV agent, which acts by sequestering core protein and attenuating core protein–mediated pathogenesis. (Hepatology 2008.)
THE INFLUENCE UPON THE SPLEEN AND THE THYROID OF THE COMPLETE REMOVAL OF THE EXTERNAL FUNCTION OF THE PANCREAS
Authors: J. E. Sweet, James W. Ellis
Journal: The Journal of Experimental Medicine (1915)

The complete removal of the function of the pancreas concerned in digestion is followed by marked changes in the spleen and in the thyroid apparatus. Second, the spleen shows an extreme simple atrophy. Third, the thyroid apparatus exhibits a constant change shown by the macroscopic transparency of the gland, by the microscopic increase in the amount of colloid, by the chemical increase of the iodine content of the gland, and by the functional test of the delayed appearance of tetany after the complete removal of the thyroid apparatus.
Toxoplasmosis following alemtuzumab based allogeneic haematopoietic stem cell transplantation
Authors: ZiYi Lim, Bob Baker, Mark Zuckermann, Jim J. Wade, Mansour Ceesay, Aloysius Y.L. Ho, Stephen Devereux, Ghulam J. Mufti, Antonio Pagliuca
Journal: Journal of Infection (2006)
FDA Chastises Red Cross
Authors: Brian Vastag
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BIOGRAPHY OF STORM VAN LEEUWEN OFFERED
Authors: H. M. BEUMER
Journal: Annals of Internal Medicine (1969)

Letters and Comments1 June 1969BIOGRAPHY OF STORM VAN LEEUWEN OFFEREDH. M. BEUMER, M.D.H. M. BEUMER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-70-6-1282_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:On p. 1345 of the December 1968 issue ofAnnals of Internal Medicinea short book review is published ofWillem Storm van Leeuwen und seine Bedeutung für die Asthmaforschung. Those interested in this account of the life and work of the pioneer allergist, Storm van Leeuwen (1882-1933), known for his demonstration that allergens are a cause of bronchial asthma in a major portion of patients, should ask for a free copy of this book and send a request to: H. M. Beumer, M.D., Armed Forces Hospital "Dr. A. Mathijsen," J. Haydnlaan 2, Utrecht, The Netherlands.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1969Volume 70, Issue 6Page: 1282-1282KeywordsAllergensArmed forcesAsthmaStorms ePublished: 1 December 2008 Issue Published: 1 June 1969 PDF downloadLoading ...
Improving outcome of percutaneous coronary intervention through application of guidelines and benchmarking: Reduction of blood transfusion as a model
Authors: Stanley J. Chetcuti, Paul M. Grossman, Debabrata Mukherjee, Eva M. Kline-Rogers, Cecelia Montoye, David Share, Michael J. O'Donnell, Ann Maxwell-Eward, William L. Meengs, John G. McGinnity, Kirit Patel, Mauro M. Moscucci
Journal: Journal of the American College of Cardiology (2003)
CXCR7-dependent angiogenic mononuclear cell trafficking regulates tumor progression in multiple myeloma
Authors: Abdel Kareem Azab, Ilyas Sahin, Feda Azab, Michele Moschetta, Yuji Mishima, Nicholas Burwick, Johann Zimmermann, Barbara Romagnoli, Kalpana Patel, Eric Chevalier, Aldo M. Roccaro, Irene M. Ghobrial
Journal: Blood (2014)
Vascular screening of over 40s will save 2000 lives a year, says health department
Authors: Zosia Kmietowicz
Journal: BMJ (2008)

Everyone in England aged between 40 and 74 is to be offered a health check every five years to screen for the risk of heart disease, diabetes, kidney disease, and stroke, the Department of Health announced this week.

The health checks are the latest in a series of reforms designed to fulfil the prime minister’s promise of a more personalised NHS.

Alan Johnson, the secretary of state for health, said that detailed modelling by the department had shown that universal vascular screening will be clinically and cost effective. Vascular disease affects four million people in England and kills 170 000 people every year, he said.

“The case for a national programme of vascular checks is compelling. We could prevent 9500 heart attacks and strokes every year and save 2000 lives. It would also reduce the health inequalities that blight the …