Captopril and Insulin Sensitivity
Authors: MARC FERRIERE
Journal: Annals of Internal Medicine (1985)

Letters and Corrections1 January 1985Captopril and Insulin SensitivityMARC FERRIERE, M.D., HENRI LACHKAR, M.D., JEAN-LOUIS RICHARD, M.D., JACQUES BRINGER, M.D., ANDRE ORSETTI, M.D., Ph.D., JACQUES MIROUZE, M.D.MARC FERRIERE, M.D., HENRI LACHKAR, M.D., JEAN-LOUIS RICHARD, M.D., JACQUES BRINGER, M.D., ANDRE ORSETTI, M.D., Ph.D., JACQUES MIROUZE, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-102-1-134_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Captopril, an oral angiotensin converting enzyme inhibitor, is widely used in the treatment of patients with hypertension and chronic congestive heart failure, and to date no effect of this drug on carbohydrate metabolism has been reported.We have recently seen three cases of unexplained hypoglycemia in insulin-dependent diabetic patients when captopril was used with their usual insulin dosage. Moreover, in a non-obese, non-insulin-dependent diabetic patient, hypoglycemia necessitated the withdrawal of hypoglycemic oral agents. To study a possible role of captopril on insulin sensitivity, we used the euglycemic glucose-clamp technique (1) in patients before and during treatment with...References1. DE FRONZOTORBINANDRES RJR. The glucose clamp technique: a method for the quantification of beta-cell sensitivity to glucose. Am J Physiol. 1979;237:214-23. Google Scholar2. MONNIERLACHKARRICHARD LHJ. Plasma beta-thromboglobulin response to insulin-induced hypoglycemia in type I diabetic patients. Diabetes. 1984;33:907-9. CrossrefMedlineGoogle Scholar3. ANANMASON ND. Vasodilator therapy of severe congestive heart failure: the special importance of an angiotensin converting enzyme inhibition with captopril. Am Heart J. 1982;104:1127-36. CrossrefMedlineGoogle Scholar4. CODY R. The effect of captopril on postural hemodynamics and autonomic responses in chronic heart failure. Am Heart J. 1982;104:1190-7. CrossrefMedlineGoogle Scholar5. DIEBERTDE FRONZO DR. Epinephrine-induced insulin resistance in man. J Clin Invest. 1980;65:717-21. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MARC FERRIERE, M.D.; HENRI LACHKAR, M.D.; JEAN-LOUIS RICHARD, M.D.; JACQUES BRINGER, M.D.; ANDRE ORSETTI, M.D., Ph.D.; JACQUES MIROUZE, M.D.Affiliations: Hopital Lapeyronie Montpellier 34000 France PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEffects of captopril on glucose metabolism and autophagy in liver and muscle from mice with type 1 diabetes and diet-induced obesityDrug interactions in Brazilian type 2 diabetes patientsDrug-Induced Glucose Alterations Part 1: Drug-Induced HypoglycemiaBlocking the renin-angiotensin-aldosterone system to prevent diabetes mellitusInfluence of nebivolol and enalapril on metabolic parameters and arterial stiffness in hypertensive type 2 diabetic patientsExercise, metformin and hypoglycaemia: a neglected entityPrevention of Type 2 Diabetes Mellitus Through Inhibition of the Renin-Angiotensin SystemEvidence for a direct effect of captopril on early steps of 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antihypertensive drugs on glucose intolerance in hypertensive nondiabetics and diabeticsAngiotensin-Converting Enzyme InhibitorsHow to treat hypertension in diabetic patientsCaptoprilCaptopril enhances insulin responsiveness of forearm muscle tissue in non-insulin-dependent diabetes mellitusDiabetes mellitus, hypertensive drug treatment and metabolic complicationsSide Effects and Metabolic Effects of Converting-Enzyme InhibitorsCAPTOPRIL, ENALAPRIL, AND BLOOD GLUCOSEAdverse Effects of Antihypertensive Drug Therapy on Glucose IntolerancePenicillamine, Captopril, and HypoglycemiaPREBEN ELLING, M.D., HANNE ELLING 1 January 1985Volume 102, Issue 1Page: 134-135KeywordsCarbohydrate metabolismDrug metabolismDrugsHeart failureHypertensionHypoglycemiaHypoglycemicsInsulinInsulin resistancePatients ePublished: 1 December 2008 Issue Published: 1 January 1985 PDF downloadLoading ...