tbuckley/cabot-search huggingface dataset:
On a Toddler's Two-Story Fall
Authors: Phillip J. Cozzi
Journal: Annals of Internal Medicine (1991)

Ad Libitum1 November 1991On a Toddler's Two-Story FallPhillip J. CozziPhillip J. CozziSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-115-9-742 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe long nerves sweetly braided down the spineare tightly woven: landing on your head,you did not break, but bounced. Just one of nine,this life has spurned the earth; you treadthe air as angels do, both bird and man combined.An acrobat, you have no use for sageadvice. My bag is bare; resilient boneis best. Whose hand has tried to test your ageand write this tale of brilliance thrownmid-air, then blot the freshly written page?O champion of human flight, you wouldoutlast experiments in gravity.Who needs diplomas, pointless accolade?Your body... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1991Volume 115, Issue 9Page: 742-742KeywordsBoneFallsNervesSpine ePublished: 1 December 2008 Issue Published: 1 November 1991 PDF downloadLoading ...
Septic Arthritis of the Hip Complicating Osteomyelitis of the Ischium
Authors: F Nouh, S Visvanathan, M S. Mourad, G Konidaris, H Van der Wall, W M. Bruce
Journal: Clinical Nuclear Medicine (2004)

A 54-year-old man with quadriplegia secondary to multiple sclerosis was admitted with an infected pressure ulcer over the right ischium. Surgical treatment included debridement and application of a vacuum dressing to the ulcer. Culture of bone scrapings from the ischium grew diphtheroids and anaerobic species. Appropriate broad-spectrum antibiotics were started. Bone scintigraphy at this time showed intense hyperemia in the right hip with increased delayed uptake in the ischium, femoral neck, and head. A leukocyte/colloid study confirmed septic arthritis and osteomyelitis of the right proximal femur. The septic arthritis/osteomyelitis was thought to be secondary to a soft-tissue communication between the ischial ulcer and the right hip. This was confirmed by subsequent surgery.
Injury on the football field.
Authors: F C Dwyer
Journal: BMJ (1973)

Laboratories, Dr. Brian Scales), the usual therapeutic level being about 1.5 ug/ml.lTo our knowledge these are the highest values reported in man so far.Possibly any beta-blocker may cause heart failure in a patient whose myocardial per- formance depends critically on sympathetic drive.However, practolol seems to be less dangerous than others in this respect, and in normal therapeutic doses causes only modest reduction of cardiac output.2Practolol has been shown to possess some sympathomimetic activity.Its positive chronotropic activity may explain why the pulse rate fell relatively little and definite bradycardia did not occur in the case presented here.This may explain, partly at least, why the patient's heart condition did not deteriorate.Another possible explanation could be the less pro- nounced effect of practolol on myocardial contractility.This case illustrates the low toxicity of practolol and its modest cardiodepressive effect which has proved valuable in the treat- ment of patients with supraventricular arrhythmias and rapid ventricular rates after myocardial infarction and cardiac surgery.-We are, etc.,
BODY MASS INDEX AND BLOOD PRESSURE IN CHILDREN: NOVEL ELECTROCARDIOGRAPHIC VALUES THAT CORRELATE WITH ECHOCARDIOGRAPHIC LEFT VENTRICULAR GEOMETRY AND MASS IN OBESE CHILDREN
Authors: Victoria L. Vetter, Darius J. McDaniel, Noreen Dugan, Danielle Haley, Lauren Cosgriff, Justine Shults
Journal: Journal of the American College of Cardiology (2014)
Wireless capsule endoscopy
Authors: P Swain
Journal: Gut (2003)

Gastroscopy, small bowel endoscopy, and colonoscopy are uncomfortable because they require comparatively large diameter flexible cables to be pushed into the bowel, which carry light by fibreoptic bundles, power, and video signals. Small bowel endoscopy is currently especially limited by problems of discomfort and failure to advance enteroscopes far into the small bowel. There is a clinical need for better methods to examine the small bowel especially in patients with recurrent gastrointestinal bleeding from this site.
Desensitization of myocardial beta-adrenergic receptors during cardiopulmonary bypass. Evidence for early uncoupling and late downregulation.
Authors: D A Schwinn, B J Leone, D R Spahn, L C Chesnut, S O Page, R L McRae, S B Liggett
Journal: Circulation (1991)

BACKGROUND Cardiopulmonary bypass (CPB), a process routinely used during cardiac surgery, is a potent stimulant to the release of endogenous catecholamines. Hence, we tested the hypothesis that CPB results in myocardial beta-adrenergic receptor (beta AR) desensitization. METHODS AND RESULTS We obtained canine transmyocardial left ventricular biopsies before, during (155 minutes), and after CPB (pre-CPB, CPB, and post-CPB, respectively) and determined beta AR density, proportion of beta 1AR to beta 2AR, and beta AR coupling capacity to adenylyl cyclase. Beta AR density was stable at 112 +/- 14 fmol/mg (pre-CPB) and 103 +/- 9 fmol/mg (CPB) but decreased post-CPB to 84 +/- 7 fmol/mg. The ratio of beta 1AR to beta 2AR (determined by two-site fit for [125I]-iodocyanopindolol competition binding with the beta 1AR selective antagonist ICI89.406) remained constant throughout (60 +/- 3: 40 +/- 3 pre-CPB, 55 +/- 3: 44 +/- 3 CPB, and 61 +/- 2: 39 +/- 2 post-CPB), revealing that both beta 1AR and beta 2AR subtypes were downregulated. A different pattern was noted in the functional properties of these receptors during CPB. Decreased maximal isoproterenol-stimulated adenylyl cyclase activity (252 +/- 14 to 216 +/- 12 pmol/30 min/mg), submaximal isoproterenol-stimulated adenylyl cyclase activity (183 +/- 10 to 157 +/- 11 pmol/30 min/mg), and zinterol-stimulated adenylyl cyclase activity (187 +/- 11 to 159 +/- 11 pmol/30 min/mg, a measure of beta 2AR subtype activation) were noted during CPB, at the time when weaning from CPB takes place. However, this desensitized pattern was found to be completely reversed by 30 minutes post-CPB, with adenylyl cyclase activities returning to pre-CPB levels or slightly higher. Control dogs that did not receive CPB showed no change in beta AR density or adenylyl cyclase activity. CONCLUSIONS These data suggest that myocardial beta AR desensitization does occur during CPB in healthy, nonischemic canine myocardium and that this pattern is reversed 30 minutes after discontinuation of CPB. In addition, a slower process of beta AR downregulation persists after discontinuation of CPB. Because successful weaning from CPB is a critical process during myocardial surgery, these findings have potentially important implications in the management of such patients.
Early Continence Recovery after Open Radical Prostatectomy with Restoration of the Posterior Aspect of the Rhabdosphincter
Authors: Francesco Rocco, Luca Carmignani, Pietro Acquati, Franco Gadda, Paolo Dell’Orto, Bernardo Rocco, Stefano Casellato, Giacomo Gazzano, Dario Consonni
Journal: European Urology (2007)
In vitro action of bombesin and bombesin-like peptides on amylase secretion, calcium efflux, and adenylate cyclase activity in the rat pancreas: a comparison with other secretagogues.
Authors: M Deschodt-Lanckman, P Robberecht, P De Neef, M Lammens, J Christophe
Journal: Journal of Clinical Investigation (1976)

Bombesin (a tetradecapeptide), the C-terminal nonapeptide of bombesin (bombesin-NP), and litorin (a parent nonapeptide), each stimulated amylase secretion from rat pancreatic fragments. These responses were not affected by atropine. The concentrations that produced half-maximal stumulation of secretion were 0.25 nM for bombesin, 0.30 nM for bombesin-NP, and 0.07 nM for litorin, as compared to 0.12 nM for caerulein and 0.80 muM for the cholinergic agent carbamylcholine. When used at maximal concentrations, bombesin, bombesin-NP, and litorin showed no action on cyclic AMP levels in the presence of 5 mM theophylline. By contrast, caerulein and secretin increased cyclic AMP levels by 27 and 208%, respectively. Bombesin, bombesin-NP, and litorin did not activate adenylate cyclase in a purified pancreatic plasma membrane preparation, whereas caerulein and secretin increased this activity 20 and 16-times, respectively...
Female genital mutilation in France
Authors: C. Gallard
Journal: BMJ (1995)

The French Family Planning Association first protested to the World Health Organization in 1977 about its continuing silence about the genital mutilation of girls in Africa and the Far East. Though initially based more upon feminist concern for women's rights than upon the association's experience with female genital mutilation, the results of the practice became increasingly real and apparent in mother and child protection centers and family planning clinics as the wives and families of African immigrants arrived in France over the next few years. An estimated 100,000 immigrants live in the Paris region. The first reaction to the increasingly prevalent evidence of prior female genital mutilation was to not intervene in the practices of other cultures. It was only after a long period of raising awareness among health personnel, magistrates, institutes, and the general public that the problem began to be seen as something which needed to be addressed in France. It eventually took the death of two girls in 1982 to bring the issue into the open and force the authorities to take a stand against the practice in France. Health professionals and women attending family planning clinics are taught about female genital mutilation in an effort to prevent its continued practice. Information is also given to immigration candidates through French consulates about general family legislation in France and the prohibition of and punishment for female genital mutilation. Punishment can be from three months upwards in prison with fines. Several cases have come to court since 1982 and sentences have been passed against both fathers and mothers. Prevention kits of posters and leaflets have recently been published and distributed in the Paris area, but they will soon be available throughout France. Moreover, medical and social teams can and do report children at risk or who have suffered female genital mutilation through the normal channels for cases of child abuse.
The risk of hepatitis B transmission from staff to patients in hemodialysis units–-an overrated problem?
Authors: Douglas R. LaBrecque, Arun K. Dhand
Journal: Hepatology (1981)

The staff and patients in hemodialysis units have the greatest hospital risk of acquiring hepatitis B (HB) infection. We followed the patients of two dialysis nurses in two different dialysis units. One nurse dialyzed 19 patients a total of 50 times during the prodrome of acute HB. The second nurse was a known, asymptomatic carrier of HBsAg who was also HBeAg(+) and anti-HBc(+). Over a 2-year period, she dialyzed 30 patients a total of 742 times. Neither group of patients showed evidence of having acquired HB, suggesting that the risk of HB transmission from staff to patient is low even in the high-risk setting of a dialysis unit and a presumably highly infectious HBeAg(+) chronic carrier. In our study, the risk in this latter setting was less than 0.0040 (binomial probability p &lt; 00.05). The data do not support restricting care of patients by health workers who are chronic carriers of the virus.
Clinical heterogeneity in childhood acute lymphoblastic leukemia with 11q23 rearrangements
Authors: CH Pui, JM Chessells, B Camitta, A Baruchel, A Biondi, JM Boyett, A Carroll, OB Eden, WE Evans, H Gadner, J Harbott, DO Harms, CJ Harrison, PL Harrison, N Heerema, G Janka-Schaub, Willem Kamps, G Masera, J Pullen, SC Raimondi, S Richards, H Riehm, S Sallan, H Sather, J Shuster, LB Silverman, MG Valsecchi, E Vilmer, Y Zhou, PS Gaynon, M Schrappe
Journal: Leukemia (2003)
THE ACHIEVEMENT OF ROBERT WILLAN*
Authors: G. H. FINDLAY
Journal: British Journal of Dermatology (1949)

Journal Article THE ACHIEVEMENT OF ROBERT WILLAN Get access G. H. FINDLAY, B.SC.Hons., M.B., B.Ch. G. H. FINDLAY, B.SC.Hons., M.B., B.Ch. Pretoria, South Africa Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 61, Issue 8-9, 1 August 1949, Pages 281–286, https://doi.org/10.1111/j.1365-2133.1949.tb11101.x Published: 01 August 1949
Physiological changes in circulating mannose levels in normal, glucose-intolerant, and diabetic subjects
Authors: Hirohito Sone, Hitoshi Shimano, Hiroyuki Ebinuma, Akimitsu Takahashi, Yoshihiro Yano, Kaoruko Tada Iida, Hiroaki Suzuki, Hideo Toyoshima, Yasushi Kawakami, Yukichi Okuda, Yuichi Noguchi, Koji Ushizawa, Kazunori Saito, Nobuhiro Yamada
Journal: Metabolism (2003)
574. Models of Cancer Cachexia: Treatment with Inhibition of NF-kB
Authors: Jad R. Maamary, Zhilong Jiang, Paula R. Clemens
Journal: Molecular Therapy (2006)

Cachexia is associated with life-threatening diseases, such as cancer and AIDS, especially gastrointestinal tract and lung cancer, where it contributes to the morbidity and mortality caused by these systemiccancers. NF-κB, a heterodimeric transcription factor, is involved in the impaired balance of protein synthesis and degradation, which characterizes cancer-induced cachexia. We have previously shown in an in vitro model using primary muscle cells, that exposure to conditioned media from certain carcinoma cell lines results in failure of myotube formation, providing an in vitro correlate of cancer cachexia.
MicroRNA-103-1 Selectively Downregulates Brain NCX1 and Its Inhibition by Anti-miRNA Ameliorates Stroke Damage and Neurological Deficits
Authors: Antonio Vinciguerra, Luigi Formisano, Pierpaolo Cerullo, Natascia Guida, Ornella Cuomo, Alba Esposito, Gianfranco Di Renzo, Lucio Annunziato, Giuseppe Pignataro
Journal: Molecular Therapy (2014)

Na+/Ca2+ exchanger (NCX) is a plasma membrane transporter that, by regulating Ca2+ and Na+ homeostasis, contributes to brain stroke damage. The objectives of this study were to investigate whether there might be miRNAs in the brain able to regulate NCX1 expression and, thereafter, to set up a valid therapeutic strategy able to reduce stroke-induced brain damage by regulating NCX1 expression. Thus, we tested whether miR-103-1, a microRNA belonging to the miR-103/107 family that on the basis of sequence analysis might be a potential NCX1 regulator, could control NCX1 expression. The role of miR-103-1 was assessed in a rat model of transient cerebral ischemia by evaluating the effect of the correspondent antimiRNA on both brain infarct volume and neurological deficits. NCX1 expression was dramatically reduced when cortical neurons were exposed to miR-103-1. This alleged tight regulation of NCX1 by miR-103-1 was further corroborated by luciferase assay. Notably, antimiR-103-1 prevented NCX1 protein downregulation induced by the increase in miR-103-1 after brain ischemia, thereby reducing brain damage and neurological deficits. Overall, the identification of a microRNA able to selectively regulate NCX1 in the brain clarifies a new important molecular mechanism of NCX1 regulation in the brain and offers the opportunity to develop a new therapeutic strategy for stroke. Na+/Ca2+ exchanger (NCX) is a plasma membrane transporter that, by regulating Ca2+ and Na+ homeostasis, contributes to brain stroke damage. The objectives of this study were to investigate whether there might be miRNAs in the brain able to regulate NCX1 expression and, thereafter, to set up a valid therapeutic strategy able to reduce stroke-induced brain damage by regulating NCX1 expression. Thus, we tested whether miR-103-1, a microRNA belonging to the miR-103/107 family that on the basis of sequence analysis might be a potential NCX1 regulator, could control NCX1 expression. The role of miR-103-1 was assessed in a rat model of transient cerebral ischemia by evaluating the effect of the correspondent antimiRNA on both brain infarct volume and neurological deficits. NCX1 expression was dramatically reduced when cortical neurons were exposed to miR-103-1. This alleged tight regulation of NCX1 by miR-103-1 was further corroborated by luciferase assay. Notably, antimiR-103-1 prevented NCX1 protein downregulation induced by the increase in miR-103-1 after brain ischemia, thereby reducing brain damage and neurological deficits. Overall, the identification of a microRNA able to selectively regulate NCX1 in the brain clarifies a new important molecular mechanism of NCX1 regulation in the brain and offers the opportunity to develop a new therapeutic strategy for stroke.
The Memphis Diabetes Continuing Care Program
Authors: John W Runyan, Roger Vander Zwaag, M Beverly Joyner, Stephen T Miller
Journal: Diabetes Care (1980)

Since 1963 a network of nurse-operated, physician-backed decentralized clinics has provided continuing care for more than 5000 diabetic patients referred from the medical center clinics. Protocols that provide therapy goals and management details are used by the nurses and nutritionists in this network. To reduce fragmentation of care, intercurrent illnesses as well as other chronic diseases are treated using protocols in these clinics or in the home. This study examines certain outcome data in a subset of 556 diabetic patients under continuing care over a 7-yr period in this network, with comparisons being made to care before referral. Blood glucose is maintained at comparable levels in both decentralized and hospital clinics. Blood pressure levels in hypertensive patients are maintained in a satisfactory range. Total hospitalization rates are reduced by 47%. For ketoacidosis and amputation, hospitalization is decreased by 69% compared with the experience before referral. The maintenance care costs are decreased substantially compared with costs before referral due to the less expensive ambulatory services and the reduced need for hospitalization. The data support the concept that decentralization is an effective means of providing continuing care to patients with diabetes mellitus.
Privatising water: implications for health.
Authors: J M Dunlop
Journal: BMJ (1987)

BACKGROUND: Assessment of tidal breathing parameters may be a useful method of predicting respiratory problems in early childhood. Low values of TPTEF/TE (the ratio of the proportion of time to reach peak tidal expiratory flow to total expiratory time) outside the neonatal period have been significantly related to respiratory tract illness with wheezing in boys in the first year of life. METHODS: TPTEF/TE measurements in the perinatal period were evaluated in nonsedated infants and the predictive value of this early measurement for subsequent respiratory morbidity during infancy was assessed. Flow during tidal breathing was measured while the infant slept quietly in a plethysmograph using a Fleisch pneumotachograph inserted into an infant face mask. Recruitment continued until traces from 60 infants with 10 consecutive flow curves without artefacts were obtained. In addition, plethysmographic measurements of airway resistance (Raw) and thoracic gas volume (TGV) were measured and specific conductance (sGaw) calculated. Parents recorded their infant9s cough and wheeze during the first 12 months of life. RESULTS: Sixty five measurements were made in 60 infants with a mean age of two days and gestational age of 40 weeks. Two observers separately calculated TPTEF/TE ratios on 25 traces randomly selected from the pool of 60. The mean difference between the two observers was -0.004 (limits of agreement 0.048 to -0.056). Thirteen infants became symptomatic (wheeze, with or without cough); their median TPTEF/TE ratio (0.349) was significantly lower than the rest of the cohort (median 0.412) and they also had significantly higher Raw and lower sGaw. The positive predictive value of a low TPTEF/TE ratio, however, was only 41%. CONCLUSIONS: These results suggest that the use of this test in the prediction of future respiratory disease in an individual is limited.
Childhood Diabetes and Its Management
Authors: Eric Brody
Journal: JAMA (1977)

Dr Craig has written a monograph that is not only informative but also truly enjoyable to read. He offers us the distillation of 20 years' experience in the diabetes clinic at the Royal Hospital for Sick Children, Glasgow, Scotland. Current references combine with charming anecdotes to provide excellent balance in each chapter. The book is directed toward the general pediatrician rather than toward the diabetologist; but current areas of controversy, such as the use of bicarbonate and continuous infusion insulin, are not avoided. While Dr Craig presents both sides of an issue, he still suggests one simple, practical approach to management. He is a realist, accepting the fact that true control is probably a myth but simultaneously avoiding a cavalier defeatist attitude. A major strength is the emphasis on behavior and communication, nonverbal as well as verbal. He stresses the value of ancillary staff, nurses, and dietitians as team members
Expert Medical Testimony
Authors: Maurice Kovnat
Journal: JAMA (1976)

<h3>To the Editor.—</h3> The letter by Burton L. Wise (235:1425,1976) brings up the important question of bias in expert medical testimony. For the past four years, I have concentrated my practice as a medical witness in litigated cases concerning workmen's compensation. My services were engaged by an attorney representing the insurance companies. The adversary was an attorney representing the worker. I had no conscious or unconscious feeling of bias. I felt only the duty of doing my work in an efficient and thorough manner to determine if the injury or disease was work-related, and if so, the extent and duration of the disabling effects. In most of these cases, there had been medical studies over a period of years, thus requiring a review of all previous records in addition to a determination of his present condition. The work was time-consuming and often required researching the literature. The suggestion that the
IMPLANTABLE DEFIBRILLATOR EARLY AFTER PRIMARY PERCUTANEOUS INTERVENTION FOR ST-ELEVATION MYOCARDIAL INFARCTION: THE DEFIBRILLATOR AFTER PRIMARY ANGIOPLASTY (DAPA) TRIAL
Authors: Fatma Demirel, Jan Paul Ottervanger, Arif Elvan, Anand R. Ramdat Misier
Journal: Journal of the American College of Cardiology (2014)
Selective Venous Sampling to Differentiate Ectopic ACTH Secretion from Pituitary Cushing's Syndrome
Authors: Dominic F. Corrigan, Marcus Schaaf, Robert A. Whaley, Carol L. Czerwinski, Jerry M. Earll
Journal: New England Journal of Medicine (1977)

Ectopic ACTH secretion may be indistinguishable from pituitary-dependent Cushing's syndrome (Cushing's disease) by current diagnostic tests.1 2 3 With increasing application of pituitary treatment for Cushing's disease, it becomes essential to distinguish between these entities. We report the use of selective catheterization and venous sampling to localize ACTH secretion in a patient with a perplexing clinical and laboratory picture compatible with either ectopic ACTH secretion or pituitary-dependent Cushing's syndrome.Case ReportOver a 14-month period a 25-year-old soldier noted centripetal obesity, bruising, emotional lability, profound weakness and wide, deeply pigmented, bronze striae. The blood pressure was 230/140 mm Hg, and he had . . .