tbuckley/cabot-search huggingface dataset:
Phototesting and phototherapy in pityriasis rubra pilaris
Authors: P. Kaskel, R.U. Peter, M. Kerscher
Journal: British Journal of Dermatology (2001)

Journal Article Phototesting and phototherapy in pityriasis rubra pilaris Get access P. Kaskel, P. Kaskel Department of Dermatology, University of Ulm, 89070 Ulm Donau, Germany Search for other works by this author on: Oxford Academic Google Scholar R.U. Peter, R.U. Peter Department of Dermatology, University of Ulm, 89070 Ulm Donau, Germany Search for other works by this author on: Oxford Academic Google Scholar M. Kerscher M. Kerscher Department of Dermatology, University of Ulm, 89070 Ulm Donau, Germany Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 144, Issue 2, 1 February 2001, Page 430, https://doi.org/10.1046/j.1365-2133.2001.04050.x Published: 01 February 2001
535 SAFETY AND EFFICACY OF ENTECAVIR IN PATIENTS RECEIVING LIVER TRANSPLANT DUE TO CHRONIC HEPATITIS B
Authors: R. Perrillo, M. Buti Ferret, F. Durand, M. Charlton, A. Gadano, G. Cantisani, K. Brown, W. Hu, C. Llamoso
Journal: Journal of Hepatology (2012)
Metabolism, Toxicity and Manner of Action of Gold Compounds used in the Treatment of Arthritis: Complete Excretion Studies and Comparison of Intravenous and Intramuscular administration of Some Gold Salts
Authors: R. H. Freyberg, W. D. Block, S. Levey
Journal: Annals of the Rheumatic Diseases (1942)

OUR investigations of the metabolism of gold were begun several years ago in an attempt to solve some of the mysteries concerned with the manner of action and toxicity of various gold salts employed in the treatment of arthritis.It seemed reasonable that, if more complete information were available regarding the fate of gold adminlistered to humans in different ways, the relative value of different types of gold preparations could be more scientifically ascertained and improved methods of administration of such drugs would result.To accomplish these studies, special methods of quantitative gold analysis were developed.However, successful analysis of the gold content of famceq was not possible until considerable information had been obtained regarding the plasma and synovial fluid concentrations of gdld and the urinary excretion of gold.Consequently, these results were reported separately as they were observed following the treatment of patients with rheumatoid arthritis with gold sodium thiomalate (myochrysine), gold sodium thiosulphate, and colloidal gold sulphide.Much valuable in- formation resulted from these earlier studies.However, they did not include fscal gold analyses, and whenever administered parenterally the salts were injected intramuscularly.When the
Haemodynamic effects of a single large dose of insulin in open heart surgery
Authors: S. SVENSSON, E. BERGLIN W-O, R. EKROTH, I. MILOCCO, F. NILSSON, G. WILLIAM-OLSSON
Journal: Cardiovascular Research (1984)

Journal Article Haemodynamic effects of a single large dose of insulin in open heart surgery Get access SVENERIC SVENSSON, SVENERIC SVENSSON * From the Department of Thoracic and Cardiovascular Surgery, and the Department of Anaesthesia, section III, Sahlgrenska Hospital, University of Göteborg, Göteborg, Sweden *Reprint requests to: Dr S E Svensson, MD, Department of Thoracic and Cardiovascular Surgery, Sahlgrenska Hospital, S-413 45 Göteborg, Sweden. Search for other works by this author on: Oxford Academic PubMed Google Scholar EVA BERGLIN W-O, EVA BERGLIN W-O From the Department of Thoracic and Cardiovascular Surgery, and the Department of Anaesthesia, section III, Sahlgrenska Hospital, University of Göteborg, Göteborg, Sweden Search for other works by this author on: Oxford Academic PubMed Google Scholar ROLF EKROTH, ROLF EKROTH From the Department of Thoracic and Cardiovascular Surgery, and the Department of Anaesthesia, section III, Sahlgrenska Hospital, University of Göteborg, Göteborg, Sweden Search for other works by this author on: Oxford Academic PubMed Google Scholar ITALO MILOCCO, ITALO MILOCCO From the Department of Thoracic and Cardiovascular Surgery, and the Department of Anaesthesia, section III, Sahlgrenska Hospital, University of Göteborg, Göteborg, Sweden Search for other works by this author on: Oxford Academic PubMed Google Scholar FOLKE NILSSON, FOLKE NILSSON From the Department of Thoracic and Cardiovascular Surgery, and the Department of Anaesthesia, section III, Sahlgrenska Hospital, University of Göteborg, Göteborg, Sweden Search for other works by this author on: Oxford Academic PubMed Google Scholar GÖRAN WILLIAM-OLSSON GÖRAN WILLIAM-OLSSON From the Department of Thoracic and Cardiovascular Surgery, and the Department of Anaesthesia, section III, Sahlgrenska Hospital, University of Göteborg, Göteborg, Sweden Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 18, Issue 11, November 1984, Pages 697–701, https://doi.org/10.1093/cvr/18.11.697 Published: 01 November 1984
Hypoxia and inflammatory synovitis: observations and speculation.
Authors: C.R Stevens, R.B Williams, A.J Farrell, D.R Blake
Journal: Annals of the Rheumatic Diseases (1991)

In recent years considerable research interest has been directed at studying the biological consequences of tissue hypoxia.As this work progresses it becomes increasingly apparent that tissue hypoxia has complex biological conse- quences.Much is now known about the natural defences of the body to hypoxia, including heat shock protein synthesis and angiogenesis.These systems are normally under rigid control, but this would seem not so in the rheumatoid joint.This accumulation of knowledge has prompted the belated reawakening of interest in joint hypoxia; it is now clear that an understanding of the physiological and pathological effects of joint hypoxia is of great importance to both clinical and research rheumatology.This review outlines joint hypoxia from a historical perspective and offers explanations for the phenomenon.Some of the more perti- nent implications of hypoxia in the context of inflammatory synovitis are discussed.
Desmin‐free cardiomyocytes and myocardial dysfunction in end stage heart failure
Authors: S. Di Somma, M.P. Di Benedetto, G. Salvatore, L. Agozzino, F. Ferranti, S. Esposito, P. La Dogana, M.I. Scarano, G. Caputo, M. Cotrufo, L. De Santo, O. de Divitiis
Journal: European Journal of Heart Failure (2004)

Our aim was to evaluate the desmin content in the myocardial tissue of patients with end-stage heart failure of ischaemic origin and to assess its role on cardiac function. We studied 18 explanted hearts from patients transplanted for end-stage heart failure due to ischaemic cardiomyopathy (ICM). Control myocardial tissue was obtained from the cardiac biopsies of six women with breast cancer taken prior to commencing chemotherapy with anthracyclines, four male donors for heart transplantation and two autoptic hearts from patients who died due to non-cardiac events. Myocardial tissue, obtained from the left ventricle (remote zone from infarcted area), was analyzed by light and confocal immunochemistry (desmin) microscopy. The desmin content of myocardial tissue was obtained by real-time PCR. Cardiac function was evaluated by echocardiographic and right heart catheterization data, obtained before heart transplantation. Confocal microscopy evaluation showed a significant decrease in the number of desmin-positive myocytes (P<0.01) in ICM hearts compared to controls. At real-time PCR evaluation, there was a reduction (P<0.01) in desmin content in the ICM patients compared to controls. A negative correlation was found between desmin-free cardiomyocytes and ejection fraction (EF) (r=-0.834; P<0.02) on echocardiogram. A negative relationship (r=-0.688) was also found between desmin-negative myocytes and capillary wedge pressure. In conclusion, the myocardial tissue of patients with end-stage heart failure of ischaemic origin, shows a decreased number in desmin-positive myocytes at immunochemistry evaluation compared to normal individuals. This deficiency in cytoskeletal intermediate filament content is associated with reduced cardiac function.
Current Therapy in Allergy, Immunology and Rheumatology
Authors: M. Lessof
Journal: Annals of the Rheumatic Diseases (1989)

This is a practical manual and deserves the place it has achieved in American medicine.From a conventional rheumatological point of view the chapters on rheumatic and connective tissue diseases offer a straightforward approach to the most important factors in treatment.There is a good and succinct account of the advantages and snags of rest, aspirin treatment, the use of splints, metatarsal bars, and all the currently used drug regimens.Reiter's syndrome, Sjogren's syndrome, and the cutaneous complications of connective tissue diseases are well dis-
Liver transplantation for HBV-related cirrhosis in Europe: An ELTR study on evolution and outcomes
Authors: Patrizia Burra, Giacomo Germani, Renè Adam, Vincent Karam, Alfredo Marzano, Pietro Lampertico, Mauro Salizzoni, Franco Filipponi, Jurgen L. Klempnauer, Denis Castaing, Murat Kilic, Luciano De Carlis, Peter Neuhaus, Sezai Yilmaz, Andreas Paul, Antonio D. Pinna, Andrew K. Burroughs, Francesco P. Russo
Journal: Journal of Hepatology (2012)
COMPARISON OF HAS-BLED SCORE TO ATRIA SCORE IN PREDICTING ABILITY FOR BLEEDING EVENTS IN JAPANESE ATRIAL FIBRILLATION PATIENTS UNDER ANTICOAGULATION
Authors: Yuya Matsue, Ryo Ninomiya, Masami Abe, Makoto Suzuki, Akihiko Matsumura, Yuji Hashimoto
Journal: Journal of the American College of Cardiology (2013)
Morphological changes of the small-intestinal mucosa of guinea pig and hamster following incubation in vitro and perfusion in vivo with unconjugated bile salts
Authors: T. S. Low-Beer, R. E. Schneider, W. O. Dobbins
Journal: Gut (1970)

Incubation in vitro of the intestine of the hamster and guinea pig with 5 mM sodium cholate and with 2 mM sodium deoxycholate and sodium chenodeoxycholate resulted in significant morphological changes compared with control incubations. Generally, no major differences were observed between proximal and distal small intestine or between the species used. Only when guinea pig intestine was incubated with 5 mM cholate was less damage found proximally than distally. Perfusion in vivo of the intestine of the hamster and guinea pig with Krebs-Ringer phosphate results in separation of the epithelium from the lamina propria without excessive shedding of epithelial cells from villous tips. This change was also seen in specimens taken before perfusion and probably represents unavoidable trauma during handling of the intestine. In contrast to studies in vitro, regional differences are readily demonstrable with perfusion of bile salts in vivo. Dihydroxy bile salts produce more marked alterations of both proximal and distal small intestine than the trihydroxy bile salt, sodium cholate. Dihydroxy bile salts result in significantly greater alterations in proximal than in distal mucosa. When 5 mM cholate at pH 6.8 is perfused in the guinea pig, absorption occurs approximately 30 times more rapidly from distal than from proximal segments, while in proximal segments 2 mM chenodeoxycholate is absorbed approximately 15 times more rapidly than 5 mM cholate. A correlation is suggested between the morphological alteration produced in the region of the small intestine by a bile acid and the amount of bile salt passing through the cell. Furthermore, it is proposed that the ileal cells may be damaged to a lesser extent by bile acids normally found in that particular species.
Recombinant Interferon Alfa-2b Combined with a Regimen Containing Doxorubicin in Patients with Advanced Follicular Lymphoma
Authors: Philippe Solal-Celigny, Eric Lepage, Nicole Brousse, Felix Reyes, Corinne Haioun, Michel Leporrier, Michel Peuchmaur, Andre Bosly, Yolaine Parlier, Pauline Brice, Bertrand Coiffier, Christian Gisselbrecht
Journal: New England Journal of Medicine (1993)

Interferon alfa and cytotoxic drugs have synergistic effects in patients with non-Hodgkin's lymphoma. In 1986, we designed a clinical trial to evaluate the benefit of concomitant administration of recombinant interferon alfa with a regimen containing doxorubicin in patients with follicular non-Hodgkin's lymphoma.
Tenure and academic freedom: Prospects and constraints
Authors: Stephen J. Ceci, Wendy M. Williams, Katrin Mueller-Johnson
Journal: Behavioral and Brain Sciences (2006)

In our target article, we took the position that tenure conveys many important benefits but that its original justification – fostering academic freedom – is not one of them. Here we respond to various criticisms of our study as well as to proposals to remedy the current state of affairs. Undoubtedly, more research is needed to confirm and extend our findings, but the most reasonable conclusion remains the one we offered – that the original rationale for tenure is poorly served by the current system as practiced at top-ranked colleges and universities.
Alimentary transit and supersensitivity after vagotomy in the rat
Authors: L. V. Gutierrez, N. Kocak, A. G. Cox
Journal: Gut (1971)

The effect of a subthreshold dose of carbachol on alimentary transit of a radioisotopically labelled fluid test meal was measured before and after vagotomy and pyloromyotomy in rats. Vagotomy itself had a transient slowing effect on the rates of gastric emptying and transit in the upper small intestine. Subthreshold carbachol had no effect before vagotomy but accelerated gastric emptying and small intestinal transit after vagotomy. These findings might explain the increased bowel frequency which is common after vagotomy.
Sensitivity and specificity of QTc dispersion for identification of risk of cardiac death in patients with peripheral vascular disease
Authors: D. Darbar, J. Luck, N. Davidson, T. Pringle, G. Main, G. McNeill, A. D Struthers
Journal: BMJ (1996)

<h3>Abstract</h3> <b>Objective</b>: To determine whether QTc dispersion, which is easily obtained from a standard electrocardiogram, can predict those patients with peripheral vascular disease who will subsequently suffer a cardiac death, despite having no cardiac symptoms or signs. <b>Design</b>: Patients with peripheral vascular disease were followed up for five years after they had had coronary angiography, radionuclide ventriculography, and their QTc dispersion calculated from their 12 lead electrocardiogram. <b>Subjects</b>: 49 such patients were then divided into three groups: survivors (34), cardiac death (12), and non-cardiac death (3). <b>Main outcome measure</b>: Survival. <b>Results</b>: The mean (SD; range) ejection fractions were similar in all three groups: survivors 45.9 (11.0; 27.0-52.0), cardiac death 44.0 (7.90; 28.5-59.0), and non-cardiac death 45.3 (4.55; 39.0-50.0). QTc dispersion was significantly prolonged in the cardiac death group compared with in the survivors (86.3 (23.9; 41.0-139) v 56.5 (25.4; 25.0-164); P=0.002). A QTc dispersion &gt;/=60 ms had a 92% sensitivity and 81% specificity in predicting cardiac death. QTc dispersion in patients with diffuse coronary artery disease was significantly (P&lt;0.05) greater than in those with no disease or disease affecting one, two, or three vessels. <b>Conclusions</b>: There is a strong link between QTc dispersion and cardiac death in patients with peripheral vascular disease. QTc dispersion may therefore be a cheap and non-invasive way of assessing the risk of cardiac death in patients with peripheral vascular disease. <h3>Key messages</h3> Key messages A QTc dispersion of 60 ms had a 92% sensitivity and an 81% specificity of predicting cardiac death over the next five years in patients with peripheral vascular disease QTc dispersion was most prominent in those with diffuse coronary disease Measurements of QTc dispersion should help in deciding whether cardiac investigations and treatments should be undertaken in individual patients as well as helping to plan the most appropriate treatment for their peripheral vascular disease
Neurological Injuries in Boxers: Lessons From One Family
Authors: Alan Byrne
Journal: JAMA (1991)

<h3>To the Editor.—</h3> I read with great interest the discourse between Charnas and Pyeritz<sup>1</sup>and Jordan and Zimmerman<sup>2</sup>regarding the use of investigative techniques in the early detection of neurological injuries in boxers during their active careers. The debate as to the usefulness of computed tomography vs careful clinical evaluation by a neurologist or neurosurgeon strikes me as being a case of the forest's being obscured by the trees. The consequences of boxing are extremely serious but seldom catastrophic, and the numerous neuropsychiatric sequelae that have been associated with boxing are troubling.<sup>3,4</sup>Surely the most pertinent factor predisposing "the further injury" is the continuation of boxing itself, or commencement thereof by those who have yet to try it. Shouldn't we be trying to prevent such neurological injuries completely rather than aiming to avert the occasional catastrophe? Lundberg<sup>5</sup>has championed this cause on numerous occasions, strongly suggesting
Increased serum levels of squamous cell carcinoma-related antigen in pemphigus
Authors: H KUDO, M. YAMAMOTO, Y. MIYACHI, K. DANNO, S. IMAMURA
Journal: British Journal of Dermatology (1988)

Serum levels of squamous cell carcinoma-related antigen (SCC-RAG) were measured in five cases of pemphigus, five cases of bullous pemphigoid and 18 cases of benign and malignant dermatoses other than SCC. The SCC-RAG titres were significantly raised in four of five patients with pemphigus, while they remained within the normal range in the other dermatoses except in one case. In three pemphigus cases in whom serial measurements were made, SCC-RAG levels seemed to be related to disease activity. The SCC-RAG levels in blister fluids were much higher than those in serum, suggesting that the skin is a major source of serum SCC-RAG. These results show that SCC-RAG is increased not only in SCC, but also in some cases of pemphigus, and suggest that pemphigus antibodies may cause the production or release of SCC-RAG.
WHO lists "best buys" for cutting deaths from non-communicable disease
Authors: J. Zarocostas
Journal: BMJ (2011)

Non-communicable diseases, the leading causes of death worldwide, are projected to significantly rise further in prevalence in the coming decades without cost effective interventions such as reducing risk factors, early detection, and timely treatment, says a report from the World Health Organization.

The agency says that non-communicable diseases—primarily cardiovascular illnesses, diabetes, cancers, and chronic respiratory diseases—caused 63% of the 57 million deaths in 2008. Nearly 80% of these deaths were in low and middle income countries. Ala Alwan, WHO’s assistant director general for non-communicable diseases and mental health, said, “Without action the NCD [non-communicable diseases] epidemic is projected to kill 52 million people annually by 2030.”

The report asserts …
HISTORY OF THE CASE OF THE HON. WALTER Q. GRESHAM, LATE SECRETARY OF STATE OF THE UNITED STATES.
Authors: W. W. JOHNSTON
Journal: JAMA (1895)

Secretary Gresham was taken ill on April 30, the earliest symptoms appearing while he was at a Cabinet meeting; on the following day he was suffering from acute epigastric pain, which was so severe as to require the use of morphia hypodermatically. On May 3 the pain changed its location to the right infra-axillary region. By reference to the thermometric chart it will be seen that during these days he had fever. At this time he was under the care of another physician. Early on the morning of May 4, I received a note asking me to call and see Secretary Gresham at the Arlington. I was requested by him to take charge of his case. The chief symptoms which were presented to me, at my first visit, were fever, embarrassed breathing, his voice being broken during conversation, and his facial expression indicating suffering; the pulse was 100 and not
Tumour necrosis factor blocking agents in refractory adult Still's disease: an observational study of 20 cases
Authors: B Fautrel
Journal: Annals of the Rheumatic Diseases (2004)

Consensus is lacking on treatment for corticosteroid resistant adult onset Still's disease (ASD).To assess anti-TNFalpha efficacy and tolerance in refractory ASD.All departments of rheumatology and internal medicine in France were contacted by mail to identify cases of refractory ASD for which anti-TNFalpha had been used. Medical information was collected using a standardised questionnaire.Of 20 patients with mean age 40.7 years (range 18-74) at treatment start and mean disease duration 8.5 years (range 2-21), the clinical expression of ASD was predominantly systemic in five patients and polyarticular in 15. Response to corticosteroids and methotrexate had been considered inadequate in all patients. Infliximab was used to treat 15 patients, and etanercept used for 10; five had received both drugs consecutively. Steroids were concurrently used in 18 patients and an immunosuppressant in 17. At a mean (SD) follow up of 13 (14) months, complete remission had occurred in five cases (of 25 treatment sequences): one receiving etanercept and four infliximab. Partial response was observed in 16 cases (seven etanercept and nine infliximab). Treatment failed in four cases (two with each anti-TNFalpha). At the last visit, anti-TNFalpha therapy was discontinued in 17 cases, 11 times because of lack (or loss) of efficacy, four times because of a side effect, and twice for other reasons.Anti-TNFalpha therapy may be helpful for some patients with refractory ASD. However, most patients achieve only partial remission. Additional information is thus needed to evaluate more precisely the risk-benefit ratio of this treatment.
Noninvasive in vivo imaging of CD4 cells in simian-human immunodeficiency virus (SHIV)–infected nonhuman primates
Authors: Michele Di Mascio, Chang H. Paik, Jorge A. Carrasquillo, Jin-Soo Maeng, Beom-Su Jang, In Soo Shin, Sharat Srinivasula, Russ Byrum, Achilles Neria, William Kopp, Marta Catalfamo, Yoshiaki Nishimura, Keith Reimann, Malcolm Martin, H. Clifford Lane
Journal: Blood (2009)
Miscibility of Human Semisynthetic Regular and Lente Insulin and Human Biosynthetic Regular and NPH Insulin
Authors: Per-Olof Olsson, Arnqvist Hans, Von Schenck Henning
Journal: Diabetes Care (1987)

The miscibility of human semisynthetic regular and lente insulins (Actrapid human/Monotard human) and human biosynthetic regular and NPH insulins (Humulin regular/Humulin NPH) was studied in vitro and in 16 insulin-dependent diabetic patients. In vitro a decrease of regular insulin was found immediately after mixture with semisynthetic lente insulin in proportions 1:4, 1:3, 1:2, 1:1, and 2:1. This was not found after mixture with human biosynthetic regular and NPH insulins. Free insulin and blood glucose were determined over 8 h after the morning injection of regular/lente (n = 9) or regular/NPH (n = 7) insulins in proportions used by the patients (∼ 1:2) mixed in one syringe or in separate syringes. Mixing the regular/lente preparations in one syringe immediately before injection resulted in a significant loss of the early rise in free insulin (P &amp;lt; .01), with a tendency to a higher free insulin in the afternoon. A corresponding change in the blood glucose profile was seen. No changes were observed in free insulin or blood glucose after mixing regular and NPH preparations compared with separate injections. We conclude that mixing human semisynthetic regular and lente insulins (Actrapid human/Monotard human) instantly results in a decrease of regular insulin, probably due to formation of a longer-acting preparation, whereas no such changes occur with human biosynthetic regular and NPH insulins (Humulin regular/Humulin NPH).