The Effect of Estrogens on Atherosclerosis
Authors: W. Thomas London, Stanley E. Rosenberg, John W. Draper, Thomas P. Almy
Journal: Annals of Internal Medicine (1961)

Article1 July 1961The Effect of Estrogens on AtherosclerosisA Post-mortem StudyW. THOMAS LONDON, M.D., STANLEY E. ROSENBERG, JOHN W. DRAPER, M.D., THOMAS P. ALMY, M.D., F.A.C.P.W. THOMAS LONDON, M.D., STANLEY E. ROSENBERG, JOHN W. DRAPER, M.D., THOMAS P. ALMY, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-55-1-63 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn the past much of the research concerning atherosclerosis has been directed toward prevention of the disease. Interest has been focused on particular groups, such as premenopausal women (1), Bantus (2), and Okinawans (3), who are relatively free of atherosclerosis presumably because of dietary habits or hormonal status.Direct evidence of the effectiveness of estrogen has been provided by Pick, Stamler, Rodbard, and Katz (4), who were able by this means to inhibit development of coronary atherosclerosis in cholesterol-fed cockerels.Of greater clinical importance is the question of whether atheromata, once it is present, can be resolved by therapeutic measures....References1. BAKERWILLIS TWFD: Coronary thrombosis among women. Amer. J. Med. Sci. 196: 815, 1938. CrossrefGoogle Scholar2. HIGGINSONPEPLER JWJ: Fat intake, serum cholesterol concentration and atherosclerosis in the South African Bantu. II. Atherosclerosis with coronary artery disease. J. Clin. Invest. 33: 1366, 1954. CrossrefMedlineGoogle Scholar3. STEINER PE: Necropsies on Okinawans; anatomic and pathologic observations. Arch. Path. 42: 359, 1946. Google Scholar4. PICKSTAMLERRODBARDKATZ JJSLN: The inhibition of coronary atherosclerosis by estrogens in cholesterol-fed chicks. Circulation 6: 276, 1952. CrossrefMedlineGoogle Scholar5. BARRRUSSEDER DPEH: Influence of estrogens on lipoproteins in atherosclerosis. Trans. Ass. Amer. Physicians 65: 102, 1952. MedlineGoogle Scholar6. ROBINSONHIGANOCOHENSNIFFENSHERER RWNWDRCJW: Effects of estrogen therapy on hormonal functions and serum lipids in men with coronary atherosclerosis. Circulation 14: 365, 1956. CrossrefMedlineGoogle Scholar7. WILENS SL: The resorption of arterial deposits in wasting disease. Am. J. Path. 23: 793, 1947. MedlineGoogle Scholar8. RIVINDIMITROFF AUJP: The incidence and severity of atherosclerosis in estrogen treated males, and in females with a hypoestrogenic or a hyperestrogenic state. Circulation 9: 533, 1954. CrossrefMedlineGoogle Scholar9. WILENS SL: Bearing of general nutritional state on atherosclerosis. Arch. Intern. Med. 79: 129, 1947. CrossrefGoogle Scholar10. WILENS SL: The relationship of chronic alcoholism to atherosclerosis. J. A. M. A. 135: 1136, 1948. CrossrefGoogle Scholar11. LATTIMER J: Personal communication. Google Scholar12. BROSS I: Is there an increased risk? Fed. Proc. 13: 815, 1954. MedlineGoogle Scholar13. BARR DP: Hormonal factors in the pathogenesis of atherosclerosis. Minnesota Med. 38: 788, 1955. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.Received for publication November 18, 1960.From the Second (Cornell) Medical Division and the Second (Cornell) Urological Service, Bellevue Hospital, and the Departments of Medicine and Surgery, Cornell University Medical College, New York, N. Y.Aided by a grant from the John A. Hartford Foundation, Inc.Requests for reprints should be addressed to Thomas P. Almy, M.D., Second (Cornell) Medical Div., Bellevue Hospital, First Ave. and Twenty-sixth St., New York 16, N. Y. 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