tbuckley/cabot-search huggingface dataset:
Translocation (3;3)(q21;q26)
Authors: Vesna Najfeld
Journal: American Journal of Hematology (1994)

Peripheral blood count Red blood cell Hemoglobin Orthochromatic erythroblasts White blood cell Myeloblasts Myelocytes Metamyelocytes Mature neutrophils Eosinophils Basophils Lymphocytes Platelet count Lactate dehydrogenase Neutrophil alkaline phosphatase
Antiarrhythmic actions of diltiazem during experimental atrioventricular reentrant tachycardias. Importance of use-dependent calcium channel-blocking properties.
Authors: M Talajic, D Papadatos, C Villemaire, M Nayebpour, S Nattel
Journal: Circulation (1990)

The purpose of this study was to determine if the known frequency-dependent effects of diltiazem on inward calcium current result in selective actions during supraventricular tachycardia. These effects were evaluated by use of an experimental model of orthodromic atrioventricular reentrant tachycardia (AVRT). AVRT was induced in 15 dogs over a wide range of retrograde conduction times before and after two doses of diltiazem. Diltiazem produced a tachycardia-related suppression of atrioventricular nodal conduction resulting in greater efficacy for faster than for slower AVRTs. The degree of slowing for tachycardias that remained inducible after diltiazem administration was greater for AVRTs with a rapid initial rate (dose 1, 29%; dose 2, 40%) than for slower AVRTs (dose 1, 11%, p less than 0.01; dose 2, 18%, p less than 0.001). Rate-dependent AVRT slowing occurred because of a time-dependent phase of AH interval prolongation after the onset of tachycardia, which was observed only after diltiazem administration. to further clarify the mechanism of diltiazem's selective actions against faster tachycardias, its effects on the minimum pathway for reentry, or wavelength, were examined in four dogs. The ratio of refractory period to revolution time (RP/RT), an index of wavelength, was measured for each AVRT before and after diltiazem administration. Diltiazem increased the positive slope of the relation between RP/RT and the AVRT rate threefold compared with control (p less than 0.05). This rate-dependent effect prevented AVRT when RP/RT became greater than unity. In conclusion, rate-dependent atrioventricular node depression by diltiazem results in greater tachycardia slowing and higher rates of termination during atrioventricular reentrant tachycardias with faster initial rates and shorter retrograde conduction intervals.
Israel's surfeit of doctors leads to strike
Authors: J Siegel-Itzkovich
Journal: BMJ (1994)

A 24 hour “warning strike” by 12 000 physicians in Israel last month was the result of frustration at the increasing struggle to find a place to work and a decent wage. The influx of 7000 immigrant doctors from the former Soviet Union during the past three years has increased the proportion of doctors in the population - already one of the highest proportions in the world; there is now one doctor for every 400 citizens.

Some 1500 elective operations and tens of thousands of outpatients visits were cancelled during the strike, and only emergencies received …
Metastatic Thyroid Carcinoma
Authors: Walter B. Shelley
Journal: JAMA (1973)

During the past 35 years, a patient has had four distinct examples of asymptomatic, gross, metastatic thyroid adenocarcinoma, each discovered on a relatively fortuitous basis. He was seeking medical attention for unrelated matters, viz, for an inguinal hernia, after automobile accident, during a routine surgical follow-up examination, and for dry skin, when the metastases in the lymph nodes, lung, axillary skin, and scalp, respectively, were noted and surgically removed. The benignity of these metastatic cancers reflects their location in noncritical sites as well as their extremely slow growth rate.
Cat Scratch Disease: The Mystery Finally Solved?
Authors: RICHARD W. EMMONS
Journal: Annals of Internal Medicine (1984)

Editorials1 February 1984Cat Scratch Disease: The Mystery Finally Solved?RICHARD W. EMMONS, M.D., PH.D.RICHARD W. EMMONS, M.D., PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-100-2-303 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe recognition of "new" diseases and of "new" pathogenic microorganisms, although less frequent now than during the first half of this century, continues to occur often enough to sustain the zest, efforts, and hopes of each generation of disease detectives and microbe fighters. Legionnaire's disease and the complex ofLegionellabacteria, Lyme arthritis and its causative spirochete, Hantaan virus as the cause of Korean hemorrhagic fever, Lassa fever, Ebola virus disease, Marburg disease, and the acquired immunodeficiency syndrome are some of the more dramatic recent examples that come to mind. The report by Wear and associates (1) of a bacterium...References1. WEARMARGILETHHADFIELDFISCHERSCHLAGELKING DATGCF. Cat scratch disease: a bacterial infection. Science. 1983;221:1403-5. CrossrefMedlineGoogle Scholar2. CARITHERS H. Cat-scratch disease: notes on its history. Am J Dis Child. 1970;119:200-3. CrossrefMedlineGoogle Scholar3. WARWICK W. The cat-scratch syndrome, many diseases or one disease? Progr Med Virol. 1967,9:256-301. MedlineGoogle Scholar4. MARGILETH A. Cat scratch disease: nonbacterial regional lymphadenitis. Pediatrics. 1968;42:803-18. MedlineGoogle Scholar5. EMMONSRIGGSSCHACHTER RJJ. Continuing search for the etiology of cat scratch disease. J Clin Microbiol. 1976;4:112-4. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: California Department of Health Services Berkeley, California PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEvaluation of an in-house cat scratch disease IgM ELISA to detect Bartonella henselae in a routine laboratory settingUnraveling Mysteries Associated with Cat-Scratch Disease, Bacillary Angiomatosis, and Related SyndromesUltrastructure of Warthin-Starry Stain-Positive Bacteria in Abscess-Forming Reticular LymphadenitisCat–scratch Disease: A Review of the LiteratureCat scratch diseaseCat scratch disease: Evidence for a bacterial etiologyUse of silver staining (Dieterle's stain) in the diagnosis of cat scratch diseaseThe cat scratch disease agent: Past and present candidatesAn unusual submandibular mass-cat scratch disease: report of caseCat Scratch Fever and Cocco-Bacillary BacteriaCHARLES L. BLUMSTEIN, M.D. 1 February 1984Volume 100, Issue 2Page: 303-304KeywordsAIDSBacteriaBorrelia burgdorferiEbola virusFeversHemorrhagic feversLegionellaLyme diseasePathogensSpirochetes Issue Published: 1 February 1984 PDF downloadLoading ...
Acetaminophen Hepatotoxicity in Alcoholics
Authors: LEONARD B. SEEFF
Journal: Annals of Internal Medicine (1986)

We have treated 6 chronic alcoholics and identified an additional 19 reported in the literature who developed severe hepatotoxicity from acetaminophen taken in apparently moderate doses. The clinical disease in these 25 patients had a characteristic pattern: mild to moderate jaundice; mild to severe coagulopathy; and strikingly abnormal aminotransferase levels, values inconsistent with either acute alcoholic hepatitis or viral hepatitis. The possible causes for the injury from ostensibly nontoxic drug levels appear to be either the induction by chronic alcohol intake of the cytochrome P-450 system responsible for converting acetaminophen to a toxic metabolite, or the effect of alcoholism and the associated malnutrition in reducing the glutathione concentration, responsible normally for preventing hepatotoxicity by conjugation with the toxic metabolite. The research data pertaining to the apparent enhanced toxicity from chronic alcoholism are reviewed. Despite the low frequency of ethanol-potentiated acetaminophen hepatotoxicity, alcoholics should be cautioned about the use of acetaminophen while they persist in heavy consumption of alcohol.
Immunologic and structural studies of the lupus/Sjögren's syndrome autoantigen, La/SSB, with a monoclonal antibody.
Authors: J B Harley, M O Rosario, H Yamagata, O F Fox, E Koren
Journal: Journal of Clinical Investigation (1985)

La/SSB is a small nuclear RNA protein against which precipitating autoantibodies are made in many patients with systemic lupus erythematosus or Sjögren's syndrome. The recent purification of La/SSB has made structural and immunologic studies possible. Consequently, a mouse hybridoma antibody (La1) was raised, after immunization and fusion, that reacted with bovine La/SSB. Results of inhibition tests with tissue extracts and fluorescent antinuclear antibody tests demonstrated that La1 reacted with bovine extracts and cells, but not with those from human, mouse, or rabbit sources. La1 reacted in Western blot and in an adapted anti-La/SSB enzyme-linked immunosorbent assay with only the 41-kD bovine La/SSB peptide and not with the smaller 29-kD bovine La/SSB peptide. RNA gels showed that La1 bound the La/SSB particle that contained the predominant La/SSB RNA species near 90 nucleotides as well as the minor RNA species, both of which were bound by the human autoimmune anti-La/SSB serum. A solid-phase assay for human autoimmune anti-La/SSB antibody using La1 was more sensitive for the detection of human anti-La/SSB than was a comparable assay using purified La/SSB, and showed that anti-La/SSB is present in nearly all Ro/SSA precipitin-positive sera. Thus, this study demonstrates that monoclonal antibody can be raised against La/SSB; that the protein moiety of bovine La/SSB differs from human, mouse, and rabbit at an epitope on the 41-kD La/SSB peptide; that the RNA bound to the La1-reactive particle was as heterogeneous as that binding the anti-La/SSB autoimmune serum; and that anti-Ro/SSA and anti-La/SSB are closely associated.
Adenosine-Mediated Inhibition of the Cytotoxic Activity and Cytokine Production by Activated Natural Killer Cells
Authors: Anna Lokshin, Tatiana Raskovalova, Xiaojun Huang, Lefteris C. Zacharia, Edwin K. Jackson, Elieser Gorelik
Journal: Cancer Research (2006)

Adenosine is an important signaling molecule that regulates multiple physiologic processes and exerts major anti-inflammatory actions. Tumors have high concentrations of adenosine, which could inhibit the function of tumor-infiltrating lymphoid cells. We investigated the ability of adenosine and its stable analogue 2-chloroadenosine (CADO) to inhibit cytokine production and cytotoxic activity of lymphokine-activated killer (LAK) cells and determined whether both these effects are initiated via a common pathway. CADO strongly inhibited cytotoxic activity of LAK cells and attenuated the production of IFN-gamma, granulocyte macrophage colony-stimulating factor, tumor necrosis factor alpha, and macrophage inflammatory protein-1alpha by LAK cells stimulated by cross-linking of the Ly49D receptor. These inhibitory effects were associated with the ability of CADO to stimulate cyclic AMP (cAMP) production and activate protein kinase A (PKA). Using cAMP analogues with different affinities for the A and B sites of the regulatory subunits of PKA types I and II, we found that activation of PKA I, but not PKA II, mimicked the inhibitory effects of CADO on LAK cell cytotoxic activity and cytokine production. Inhibitors of the PKA catalytic subunits (H89 and PKI(14-22) peptide) failed to abrogate the inhibitory effects of CADO whereas Rp-8-Br-cAMPS, an antagonist of the RI subunit, blocked the inhibitory effects of CADO. We conclude that the inhibitory effects of adenosine are probably mediated via cAMP-dependent activation of the RI subunits of PKA I but are independent of the catalytic activity of PKA. Tumor-produced adenosine could be a potent tumor microenvironmental factor inhibiting the functional activity of tumor-infiltrating immune cells.
Use of Glucagon in the Treatment of Acute Diverticulitis
Authors: O. Daniel, P. K. Basu, H. M. Al-Samarrae
Journal: BMJ (1974)

Glucagon given intravenously to 20 patients with acute diverticulitis was followed by symptomatic relief within an average of 12 hours and obviated the need for therapy with analgesics or other antispasmodics. In a similar group of patients receiving conventional treatment symptoms persisted for an average of 96 hours. The administration of glucagon had no apparent effect on abdominal symptoms which mimicked those of diverticulitis but were caused by other conditions. There was no clinically apparent difference in effectiveness between continuous infusion and intermittent injection of glucagon.
Successful topical immunotherapy of bowenoid papulosis with imiquimod.
Authors: W. Petrow, R. Gerdsen, M. Uerlich, O. Richter, T. Bieber
Journal: British Journal of Dermatology (2001)

Journal Article Successful topical immunotherapy of bowenoid papulosis with imiquimod Get access W. Petrow, W. Petrow Search for other works by this author on: Oxford Academic Google Scholar R. Gerdsen, R. Gerdsen Search for other works by this author on: Oxford Academic Google Scholar M. Uerlich, M. Uerlich Search for other works by this author on: Oxford Academic Google Scholar O. Richter, O. Richter Department of Obstetrics and Gynaecology, University of Bonn, Germany Correspondence: Welisar Petrow, Sigmund Freud Straße 25, 53105 Bonn, GermanyE‐mail: welisar.petrow@meb.uni‐bonn.de Search for other works by this author on: Oxford Academic Google Scholar T. Bieber T. Bieber Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 145, Issue 6, 1 December 2001, Pages 1022–1023, https://doi.org/10.1046/j.1365-2133.2001.04514.x Published: 01 December 2001
False-Positive lodine-131 Whole Body Scan Due to Pectus Excavatum
Authors: SERESH MUHERJI, HARVEY A. ZIESSMAN, JERRY M. EARLL, JOHN W. KEYES
Journal: Clinical Nuclear Medicine (1988)

A 44-year-old woman with follicular cell carcinoma of the thyroid was treated with 150 mCi of radioactive I-131 6 weeks after a subtotal thyroidectomy. A whole body scan performed 5 days after therapy demonstrated diffuse uptake in the left lung field, but no other evidence of distant metastases. A review of her recent chest x-ray showed a prominant pectus excavatum with a shift of the heart shadow into the left lung field. A Tc-99m labeled red blood cell scan confirmed that the I-131 uptake in the left lung field represented heart blood pool.
The Harvard Southern California Chronic Ozone Exposure Study: assessing ozone exposure of grade-school-age children in two Southern California communities.
Authors: A S Geyh, J Xue, H Ozkaynak, J D Spengler
Journal: Environmental Health Perspectives (2000)

The Harvard Southern California Chronic Ozone Exposure Study measured personal exposure to, and indoor and outdoor ozone concentrations of, approximately 200 elementary school children 6-12 years of age for 12 months (June 1995-May 1996). We selected two Southern California communities, Upland and several towns located in the San Bernardino mountains, because certain characteristics of those communities were believed to affect personal exposures. On 6 consecutive days during each study month, participant homes were monitored for indoor and outdoor ozone concentrations, and participating children wore a small passive ozone sampler to measure personal exposure. During each sampling period, the children recorded time-location-activity information in a diary. Ambient ozone concentration data were obtained from air quality monitoring stations in the study areas. We present ozone concentration data for the ozone season (June-September 1995 and May 1996) and the nonozone season (October 1995-April 1996). During the ozone season, outdoor and indoor concentrations and personal exposure averaged 48.2, 11.8, and 18.8 ppb in Upland and 60.1, 21.4, and 25.4 ppb in the mountain towns, respectively. During the nonozone season, outdoor and indoor concentrations and personal exposure averaged 21.1, 3.2, and 6.2 ppb in Upland, and 35.7, 2.8, and 5.7 ppb in the mountain towns, respectively. Personal exposure differed by community and sex, but not by age group.
THE BENEDICT MODIFICATION OF THE BOAS TEST FOR OCCULT BLOOD IN THE FECES.
Authors: A. L. BENEDICT
Journal: JAMA (1907)

This method was presented by title to the 1906 meeting of the Medical Society of the State of New York and published in the<i>New York State Journal of Medicine</i>, May, 1906. So many inquiries have been received regarding the test that it may be pardonable to repeat the substance of the original paper in diagrammatic form. The test is, of course, the same in principle as the original Boas test, which likewise is merely an adaptation to feces of the time-honored guaiac test for hemoglobin. The present modification avoids the delay and spurting of feces incident to extraction of fats which are inevitable when gasoline is not used. It seems to me neither more nor less delicate than the original Boas test. The guaiac test is not especially sensitive and nearly 10 per cent, of blood must be present in the feces
Effects of cardiac transplantation on bioenergetic abnormalities of skeletal muscle in congestive heart failure.
Authors: J R Stratton, G J Kemp, R C Daly, M Yacoub, B Rajagopalan
Journal: Circulation (1994)

BACKGROUND Patients with advanced heart failure have bioenergetic abnormalities of skeletal muscle metabolism during exercise. Using 31P magnetic resonance spectroscopy, we sought to determine whether skeletal metabolic responses to exercise are normalized by orthotopic cardiac transplantation. METHODS AND RESULTS Four groups were studied: healthy normal volunteers (n = 9), subjects awaiting heart transplantation (n = 10), subjects &lt; 6 months (mean, 4 months) after transplant (n = 9), and subjects &gt; 6 months (mean, 15 months) after transplant (n = 8). None of the posttransplant patients had biopsy evidence of rejection at the time of study. There were no significant differences in age, preoperative functional class, or symptom duration among the three patient groups. Metabolic responses were monitored in the dominant arm during incremental weight pull exercise and 10 minutes of recovery by 31P magnetic resonance spectroscopy, with measurement of pH and the phosphocreatine (PCr)/(PCr + inorganic phosphate [Pi]) ratio, an index of PCr concentration. In addition, based on recovery data, the rate of PCr resynthesis was calculated as a measure of oxidative metabolism that is independent of work level, recruitment, or muscle mass, and the effective maximal rate of mitochondrial ATP synthesis (Vmax) was determined. Analysis was by ANOVA. There were no differences between groups in pH or PCr/(PCr + Pi) at rest. Compared with the normal control group, the pretransplant group had a decreased exercise duration (11.3 +/- 2.5 versus 15.0 +/- 1.3 minutes, P = .02), a lower submaximal exercise PCr/(PCr + Pi) ratio (0.58 +/- 0.11 versus 0.76 +/- 0.08, P &lt; .05), a reduced PCr resynthesis rate (13 +/- 6 versus 22 +/- 9 mmol/L per minute, P &lt; .05), and a lower calculated Vmax (26 +/- 14 versus 53 +/- 26 mmol/L per minute, P &lt; .05). In the group studied early after transplantation, all the changes noted in the pretransplant group persisted and were if anything somewhat worse. In the group studied late after transplantation, there was a significant improvement in the PCr resynthesis rate compared with the early-posttransplant group (27 +/- 6 late versus 15 +/- 6 mmol/L per minute early, P &lt; .05) and statistically nonsignificant trends toward improvements in submaximal exercise pH (6.86 +/- 0.24 late versus 6.72 +/- 0.24 early) and submaximal PCr/(PCr + Pi) ratio (0.56 +/- 0.14 late versus 0.44 +/- 0.15 early) and Vmax (45 +/- 21 late versus 33 +/- 15 mmol/L per minute early). However, compared with normal subjects, exercise duration and submaximal PCr/(PCr + Pi) were still reduced in the late-posttransplant group. CONCLUSIONS Despite successful heart transplantation, skeletal muscle abnormalities of advanced heart failure persist for indefinite periods, although partial improvement occurred at late times. The persistent abnormalities may contribute to the reduced exercise capacity that is present in most patients after transplantation.
New Strategies in Ewing Sarcoma: Lost in Translation?
Authors: Fernanda I. Arnaldez, Lee J. Helman
Journal: Clinical Cancer Research (2014)

Ewing sarcoma is the second most common pediatric malignant bone tumor. Aggressive multimodality therapy has led to an improvement in outcomes, particularly in patients with localized disease. However, therapy-related toxicities are not trivial, and the prognosis for patients with relapsed and/or metastatic disease continues to be poor. In this article, we outline some of the promising therapies that have the potential to change the Ewing sarcoma therapeutic paradigm in the not-too-distant future: insulin-like growth factor receptor inhibitors, targeting of the fusion protein, epigenetic manipulation, PARP inhibitors, and immunotherapy.
Report of the National Formulary Antianemia Preparations Advisory Board
Authors: Anita B. Robbins
Journal: JAMA (1961)

THE National Formulary Antianemia Preparations Advisory Board was established April 17, 1959. This Board consists of 5 members, Dr. Steven O. Schwartz, Chairman; Dr. Anita B. Robbins, Secretary; Dr. Paul S. Hagen; Dr. Wayne Rundles, and Dr. Louis R. Wasserman. Preparations intended for treatment of pernicious anemia by oral administration require approval of this Board. One N. F. Unit of Liver Extract, Liver Solution, Liver with Stomach, or Powdered Stomach is defined as that amount of an otherwise acceptable product which has been shown to produce, when administered daily by mouth, clinical and hematologic responses, that are considered by the Board to be satisfactory, in patients with addisonian pernicious anemia. The method of obtaining the necessary clinical data and approval of these products is described in the section under "Evaluation of Oral Liver and Stomach Preparations," in the First Interim Revision Announcement to the Eleventh Edition of the National Formulary.
Serological Findings in Infectious Mononucleosis
Authors: L. W. Kleppe
Journal: JAMA (1963)

To the Editor:  —I believe exception should be taken to a portion of the reply to the question entitled Infectious Mononucleosis from the Questions and Answers section ofThe Journal( 181 :1156 [Sept 29] 1962). Misinterpretation of the results of the heterophil agglutination procedure with absorption does an injustice to a procedure which comes unusually close to being a pathognomonic diagnostic tool.  The presumptive titer is merely a screening procedure to acquaint the serologist with those sera with which he might obtain a three-tube absorption with the Forssman and/or beef cell antigens. Therefore, any heterophil agglutination titer of 1:28 or greater should receive the benefit of the Davidsohn absorption differential. Negative results provide no information, but a positive absorption comes as close to an absolute diagnostic tool as anything we possess. An example of a low but significant titer is: presumptive, 1:28; after absorption with Forssman antigen, 1:7; after beef