tbuckley/cabot-search huggingface dataset:
Reliability and sensitivity to change of the Simple Erosion Narrowing Score compared with the Sharp-van der Heijde method for scoring radiographs in rheumatoid arthritis
Authors: E M Dias, C Lukas, R Landewe, S Fatenejad, D van der Heijde
Journal: Annals of the Rheumatic Diseases (2007)

To compare the performance of a simplified scoring method for structural damage on radiographs of patients with rheumatoid arthritis (the Simple Erosion Narrowing Score or SENS) with the Sharp-van der Heijde Score (SHS) as reference.We used the radiographic data from the Trial of Etanercept and Methotrexate with Radiographic Patient Outcomes (TEMPO trial). The SENS was derived from the crude SHS data. Inter-observer reliability for status scores and change scores was determined by intraclass correlation coefficients and by the Smallest Detectable Change method. The ability to discriminate between treatment groups was assessed by the Mann-Whitney U test. Stratifying the sensitivity to change and discriminative ability for different levels of disease severity assessed a potential ceiling effect.Inter-observer reliability was similar for both methods. Intraclass correlation coefficients were higher for status scores than for change scores. The Smallest Detectable Change was 4.98 (1.1% of possible maximum score) for SHS and 2.28 (3.5%) for SENS. Sensitivity of SENS to detect progression above the Smallest Detectable Change, with reference SHS, ranged from 45.0 to 88.7%. Specificity ranged from 81.5 to 97.3%, and the kappa coefficient (between-method agreement) ranged from 0.58 to 0.66. Discriminative ability between treatment groups was good and similar for both methods. A ceiling effect could not be detected.With regard to most of the tested properties, the performance of SENS is as good as that of SHS. This confirms that SENS is a valuable method, which may be feasible in clinical practice.
Outpatient Assessment of Karlsburg Diabetes Management System–Based Decision Support
Authors: Petra Augstein, Lutz Vogt, Klaus-Dieter Kohnert, Ernst-Joachim Freyse, Peter Heinke, Eckhard Salzsieder
Journal: Diabetes Care (2007)

We sought to assess the benefit of the Karlsburg Diabetes Management System (KADIS) in conjunction with the continuous glucose monitoring system (CGMS) in an outpatient setting.A multicentric trial was performed in insulin-treated outpatients (n = 49), aged 21-70 years, with a mean diabetes duration of 14.2 years. Subjects were recruited from five outpatient centers and randomized for CGMS- or CGMS/KADIS-based decision support and followed up for 3 months. After two CGMS monitorings, the outcome parameters A1C (%), mean sensor glucose of the CGMS profile (MSG) (mmol/l), and duration of hyperglycemia (h/day) were evaluated.In contrast with the CGMS group (0.27 +/- 0.67%), mean change in A1C decreased in the CGMS/KADIS group during the follow-up (-0.34 +/- 0.49%; P < 0.01). MSG levels were not affected in the CGMS group (7.75 +/- 1.33 vs. 8.45 +/- 2.46 mmol/l) but declined in the CGMS/KADIS group (8.43 +/- 1.33 vs. 7.59 +/- 1.47 mmol/l; P < 0.05). Net KADIS effect (-0.60 [95% CI -0.96 to - 0.25%]; P < 0.01) was associated with reduced duration of hyperglycemia (4.6 vs. 1.0 h/day; P < 0.01) without increasing hypoglycemia. Multiple regression revealed that the A1C outcome was dependent on KADIS-based decision support. Age, sex, physician's specialty, diabetes type, and BMI had no measurable effect.If physicians were supported by CGMS/KADIS in therapeutic decisions, they achieved better glycemic control for their patients compared with support by CGMS alone. KADIS is a suitable decision support tool for physicians in outpatient diabetes care and has the potential to improve evidence-based management of diabetes.
Morphometry of the small pulmonary arteries in man.
Authors: K Horsfield
Journal: Circulation Research (1978)

From a resin cast of a normal pulmonary arterial tree, the diameter, length, and number of branches in each order were determined for arteries from 25 to 300 micrometer in diameter. Histological sections 120-micrometer thick were cut from a normal human lung in which the pulmonary artery had been injected with a mixture of ink and gelatin. Similar measurements were made on arteries from 10 to 70 micrometer in diameter, and the mode of origin of the capillaries was studied. The data thus obtained were found to correspond reasonably well to values previously estimated by extrapolation from data for arteries of 100 micrometer or more in diameter. The branching rules apply down to arteries of about 10-15 micrometer in diameter, the estimated number of which is 73 million. Distal to these vessels, capillaries arise either directly from small arteries or indirectly via precapillaries which are given off in great numbers and diverse patterns from the small arteries
Elevated brain natriuretic peptide predicts mortality in interstitial lung disease
Authors: T.J. Corte, S.J. Wort, M.A. Gatzoulis, R. Engel, G. Giannakoulas, P.M. Macdonald, A.U. Wells
Journal: European Respiratory Journal (2010)

Elevated pulmonary vascular resistance portends a poor prognosis across interstitial lung disease (ILD), irrespective of the histospecific diagnosis. Currently, no noninvasive surrogate prognostic marker exists. We explore the prognostic value of brain natriuretic peptide (BNP) and echocardiography across ILD. ILD patients with BNP concentrations performed during 2005-2007 were reviewed (n = 90). Echocardiography tapes were reviewed by a cardiologist blinded to other results. Outcome was evaluated for survival against BNP and echocardiograph parameters. A priori threshold values and composite markers were evaluated against survival. During follow-up (20±9 months) there were 28 deaths (31%). BNP correlated with right heart echocardiographic indices, including right ventricular systolic pressure (RVSP) (R(2) = 0.18, p = 0.0002) but not with parameters of left heart function. Nonsurvivors had higher BNP and RVSP levels than survivors. BNP ≥20 pmol·L(-1) (hazard ratio (HR) 2.93, 95% CI 1.28-6.73; p = 0.01) and moderate-severe pulmonary hypertension (HR 2.53, 95% CI 1.15-5.57; p = 0.02) were associated with increased mortality, independent of age, sex and pulmonary function. Patients with BNP ≥20 pmol·L(-1) had a 14-fold increased mortality over those with BNP <4 pmol·L(-1). Increased BNP levels and/or echocardiographic markers of right ventricular dysfunction were associated with increased mortality across ILD. The link between vascular parameters and mortality supports the concept that pulmonary vascular disease contributes to the final common pathway seen across ILD.
On Mechanical Dilatation of the Cervix Uteri
Authors: J. M. Duncan
Journal: BMJ (1873)

<b>1009</b> Key objectives for this presentation include identifying the parts of a well-built clinical question and an introduction to types of studies, and identifying evidence-based medicine searching strategies to improve MEDLINE retrieval of potentially relevant articles. Various search techniques and features of PubMed will be highlighted, such as Clinical Queries and Special Queries. Searching for clinical study categories such as diagnosis and therapy and "Cancer Topic Searches" will be illustrated. Using PubMed9s MyNCBI feature to store and update search strategies, and to filter search strategies, will also be featured.
Update in Pulmonary Vascular Disease 2015
Authors: Bradley A. Maron, Mark T. Gladwin, Marc A. Simon
Journal: American Journal of Respiratory and Critical Care Medicine (2016)

Progress in pulmonary vascular disease medicine in 2015 included important contributions across the basic, clinical, and population sciences.Key advances enhanced understanding of right heart failure pathophysiology in pulmonary arterial hypertension (PAH), particularly with respect to right ventricular (RV)-arterial coupling and biomarker profiles, and findings from seminal PAH clinical trials this year redefined patient treatment strategies for the current era.This review aims to highlight developments in these areas, as well as to summarize key discoveries from 2015 that enhance our knowledge of contemporary basic mechanisms underlying pulmonary vascular injury and, ultimately, PAH.
Immunomagnetic Detection and Clinical Significance of Micrometastatic Tumor Cells in Malignant Melanoma Patients
Authors: Ragnar S. Faye, Steinar Aamdal, Hanne K. Høifødt, Erling Jacobsen, Linn Holstad, Eva Skovlund, Øystein Fodstad
Journal: Clinical Cancer Research (2004)

Abstract Purpose: Positive associations between the presence of micrometastatic tumor cells and disease aggressiveness have been reported in several tumor types, but the clinical implications are still not established. We wanted to test a new, sensitive immunomagnetic detection method on bone marrow (BM) and peripheral blood (PB) samples from patients with malignant melanoma and relate the findings to clinical outcome. Experimental Design: Samples from 210 patients admitted for relapse of cutaneous melanoma were examined. Mononuclear cell fractions isolated from BM and PB were incubated with superparamagnetic particles coated with antimelanoma antibodies. Live tumor cells with bound beads were isolated with a magnet and identified in a microscope as cell-bead rosettes. Beads without antibody or with an irrelevant antibody were used as controls. The whole procedure was completed within 2–3 h. The identity of the cells was confirmed with a new double labeling procedure with fluorescent microparticles. Results: Rosetted melanoma cells were found in BM aspirates of 35 of 186 (19%) patients, but in only 2 of 208 (1%) PB samples. The controls were all negative. After a median observation time of 1.1 year (range, 0–6.8 years), patients with tumor cells in BM showed a significantly shorter overall survival from time of BM aspiration (P = 0.009). In multiple regression analysis, a positive BM test was a strong indicator of overall survival (P = 0.021), associated with disease stage (American Joint Committee on Cancer) and with the number of metastatic sites, but not with the primary (Breslow) tumor depth and morphology. Conclusions: The results demonstrate the prognostic significance of detecting BM micrometastasis in melanoma patients. The results strengthen the validity of the immunobead technique. In contrast to other techniques, the method identifies intact, live tumor cells that can be further characterized, making the assay attractive for extended use.
The difficult concussion patient: what is the best approach to investigation and management of persistent (&gt;10 days) postconcussive symptoms?
Authors: Michael Makdissi, Robert C Cantu, Karen M Johnston, Paul McCrory, Willem H Meeuwisse
Journal: British Journal of Sports Medicine (2013)

Concussion in sport typically recovers clinically within 10 days of injury. In some cases, however, symptoms may be prolonged or complications may develop. The objectives of the current paper are to review the literature regarding the difficult concussion and to provide recommendations for an approach to the investigation and management of patients with persistent symptoms.A qualitative review of the literature on concussion in sport was conducted with a focus on prolonged recovery, long-term complications and management including investigation and treatment strategies. MEDLINE and Sports Discus databases were reviewed.Persistent symptoms (>10 days) are generally reported in 10-15% of concussions. This figure may be higher in certain sports (eg, ice hockey) and populations (eg, children). In general, symptoms are not specific to concussion and it is important to consider and manage coexistent pathologies. Investigations may include formal neuropsychological testing and conventional neuroimaging to exclude structural pathology. Currently, there is insufficient evidence to recommend routine clinical use of advanced neuroimaging techniques or genetics markers. Preliminary studies demonstrate the potential benefit of subsymptom threshold activity as part of a comprehensive rehabilitation programme. Limited research is available on pharmacological interventions.Cases of concussion in sport where clinical recovery falls outside the expected window (ie, 10 days) should be managed in a multidisciplinary manner by healthcare providers with experience in sports-related concussion. Important components of management, after the initial period of physical and cognitive rest, include associated therapies such as cognitive, vestibular, physical and psychological therapy, assessment for other causes of prolonged symptoms and consideration of a graded exercise programme at a level that does not exacerbate symptoms.
Surface alterations of erythrocytes in Plasmodium falciparum malaria. Antigenic variation, antigenic diversity, and the role of the spleen.
Authors: M Hommel, P H David, L D Oligino
Journal: The Journal of Experimental Medicine (1983)

The surface of erythrocytes infected with late developmental stages of Plasmodium falciparum is profoundly altered and new antigenic determinants can be detected by surface immunofluorescence using immune squirrel monkey serum. The expression of these parasite-specific antigenic determinants on the surface of the host erythrocyte can be modulated by the presence or absence of the spleen and by immune pressure. An antigenic switch occurred when a cloned population of the Ugandan Palo Alto strain of P. falciparum was transferred from a splenectomized into an intact monkey and this switch was reversible. In another strain (Indochina-1), we showed that the parasites isolated during secondary and recrudescent peaks expressed erythrocyte-associated surface antigens different from the parasites isolated during the primary infection; six variant antigenic types distinct from the original population were isolated in this way. The passive transfer of immune serum can induce antigenic variation and this can occur in a cloned parasite. The various mechanisms of antigenic variation in P. falciparum are discussed in the context of strain-specific diversity and the role of antigenic diversity in acquired immunity.
Complicated relationships of amino acid substitution in hepatitis C virus core region and<i>IL28B</i>genotype influencing hepatocarcinogenesis
Authors: Norio Akuta, Fumitaka Suzuki, Yuya Seko, Yusuke Kawamura, Hitomi Sezaki, Yoshiyuki Suzuki, Tetsuya Hosaka, Masahiro Kobayashi, Tasuku Hara, Mariko Kobayashi, Satoshi Saitoh, Yasuji Arase, Kenji Ikeda, Hiromitsu Kumada
Journal: Hepatology (2012)

The impact of amino acid (aa) 70 substitution in the core region on hepatocarcinogenesis and survival for liver-related death in patients of hepatitis C virus (HCV) genotype 1b (HCV-1b), who had not received antiviral therapy, is unknown. The relationships among aa 70 substitution, IL28B genotype, and hepatocarcinogenesis are also not clear. A total of 1,181 consecutive HCV-infected patients, who had not received antiviral therapy, were included in a follow-up study to determine predictive factors of hepatocarcinogenesis and survival for liver-related death. The cumulative hepatocarcinogenesis rates in HCV-1b of Gln70(His70) (glutamine (histidine) at aa 70) were significantly higher than those in HCV-1b of Arg70 (arginine at aa 70) and HCV-2a/2b. The cumulative survival rates for liver-related death in HCV-1b of Gln70(His70) were significantly lower than those in HCV-1b of Arg70 and HCV-2a/2b. Multivariate analysis identified gender (male), age (≥ 60 years), albumin (<3.9 g/dL), platelet count (<15.0 × 10(4) /mm(3) ), aspartate aminotransferase (≥ 67 IU/L), and HCV subgroup (HCV-1b of Gln70(His70)) as determinants of both hepatocarcinogenesis and survival rates for liver-related death. In HCV-1b patients, the cumulative change rates from Arg70 to Gln70(His70) by direct sequencing were significantly higher than those from Gln70(His70) to Arg70. In patients of Arg70 at the initial visit, the cumulative change rates from Arg70 to Gln70(His70) in IL28B rs8099917 non-TT genotype were significantly higher than those in the TT genotype.Substitution of aa 70 in the core region of HCV-1b is an important predictor of hepatocarcinogenesis and survival for liver-related death in HCV patients who had not received antiviral therapy. The IL28B genotype might partly affect changes over time of dominant amino acid in core aa 70 of HCV-1b.
A Long-Time Study of the Blood Lipids of Two Students of Atherosclerosis
Authors: IRVINE H. PAGE, LENA A. LEWIS
Journal: Circulation (1969)

A study of serum cholesterol and lipoproteins covering periods of 28 years in a male physician and 17 years in a female research worker showed relative constancy for the cholesterol levels and greater variability for the lipoproteins. Cholesterol was reduced sharply and temporarily just after each influenzal infection. In the male, the level of cholesterol was slightly above 300 mg/100 ml for more than 13 years. An extremely low cholesterol and high carbohydrate diet proved unacceptable. A more liberal, relatively low-saturated fat, low-cholesterol, and high polyunsaturated fatty acid diet with about 30% of the calories from fat, maintained the cholesterol level between 230 and 270 mg and has been followed with relish for a number of years. A myocardial infarction occurred 27 years after the study began. Clofibrate since then has reduced the cholesterol level further. The female subject is in good health and maintains cholesterol levels slightly below 300 mg on a usual American diet. She is 10 years younger than the male. Her —S 40-70 lipoproteins have usually been well below the male subject's. Weight gain and lack of exercise seemed regularly to increase both levels. The data are presented because we believe them to be accurate; their interpretation is for the reader. We hope he must wait for some time for the outcome of the study.
Heart Failure—An Epidemic or a Shifting Landscape?
Authors: Mary Norine Walsh
Journal: JAMA Internal Medicine (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Cystathionine γ-Lyase Protects against Renal Ischemia/Reperfusion by Modulating Oxidative Stress
Authors: Eelke M. Bos, Rui Wang, Pauline M. Snijder, Miriam Boersema, Jeffrey Damman, Ming Fu, Jill Moser, Jan-Luuk Hillebrands, Rutger J. Ploeg, Guangdong Yang, Henri G.D. Leuvenink, Harry van Goor
Journal: Journal of the American Society of Nephrology (2013)

Hydrogen sulfide (H2S) is an endogenous gasotransmitter with physiologic functions similar to nitric oxide and carbon monoxide. Exogenous treatment with H2S can induce a reversible hypometabolic state, which can protect organs from ischemia/reperfusion injury, but whether cystathionine γ-lyase (CSE), which produces endogenous H2S, has similar protective effects is unknown. Here, human renal tissue revealed abundant expression of CSE, localized to glomeruli and the tubulointerstitium. Compared with wild-type mice, CSE knockout mice had markedly reduced renal production of H2S, and CSE deficiency associated with increased damage and mortality after renal ischemia/reperfusion injury. Treatment with exogenous H2S rescued CSE knockout mice from the injury and mortality associated with renal ischemia. In addition, overexpression of CSE in vitro reduced the amount of reactive oxygen species produced during stress. Last, the level of renal CSE mRNA at the time of organ procurement positively associated with GFR 14 days after transplantation. In summary, these results suggest that CSE protects against renal ischemia/reperfusion injury, likely by modulating oxidative stress through the production of H2S.
Net Reclassification Improvement: Computation, Interpretation, and Controversies
Authors: Maarten J.G. Leening, Moniek M. Vedder, Jacqueline C.M. Witteman, Michael J. Pencina, Ewout W. Steyerberg
Journal: Annals of Internal Medicine (2014)

The net reclassification improvement (NRI) is an increasingly popular measure for evaluating improvements in risk predictions. This article details a review of 67 publications in high-impact general clinical journals that considered the NRI. Incomplete reporting of NRI methods, incorrect calculation, and common misinterpretations were found. To aid improved applications of the NRI, the article elaborates on several aspects of the computation and interpretation in various settings. Limitations and controversies are discussed, including the effect of miscalibration of prediction models, the use of the continuous NRI and "clinical NRI," and the relation with decision analytic measures. A systematic approach toward presenting NRI analysis is proposed: Detail and motivate the methods used for computation of the NRI, use clinically meaningful risk cutoffs for the category-based NRI, report both NRI components, address issues of calibration, and do not interpret the overall NRI as a percentage of the study population reclassified. Promising NRI findings need to be followed with decision analytic or formal cost-effectiveness evaluations.
A Placebo-Controlled Comparison of the Efficiency of Triple- and Monotherapy in Category III B Chronic Pelvic Pain Syndrome (CPPS)
Authors: Volkan Tuğcu, Ali İhsan Taşçı, Adem Fazlıoğlu, Gökhan Gürbüz, Emin Özbek, Selçuk Şahin, Fatih Kurtuluş, Mete Çek
Journal: European Urology (2006)
Oral terbinafine treatment for toenail onychomycosis: reply from authors
Authors: L. Molin, M. Tarstedt, C. Engman
Journal: British Journal of Dermatology (2001)

Journal Article Oral terbinafine treatment for toenail onychomycosis: reply from authors Get access L. Molin, L. Molin Department of Dermatology, Örebro Medical Centre Hospital Örebro Sweden E‐mail: lars.molin@orebroll.se Search for other works by this author on: Oxford Academic Google Scholar M. Tarstedt, M. Tarstedt Department of Dermatology, Örebro Medical Centre Hospital Örebro Sweden Search for other works by this author on: Oxford Academic Google Scholar C. Engman C. Engman Department of Dermatology, Örebro Medical Centre Hospital Örebro Sweden Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 144, Issue 5, 1 May 2001, Page 1098, https://doi.org/10.1046/j.1365-2133.2001.04218.x Published: 01 May 2001