tbuckley/cabot-search huggingface dataset:
Combat Injuries in Iraq and Afghanistan Help Rewrite the Book on War Surgery
Authors: Carolyn J. Hildreth
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Health Disparities — Less Talk, More Action
Authors: Nicole Lurie
Journal: New England Journal of Medicine (2005)

During the past decade, hundreds of articles have been published documenting the existence of racial and ethnic disparities in health and health care — a data deluge that has led many observers to suggest that it is time to stop documenting disparities and turn our efforts to doing something about them. Three articles in this issue of the Journal once again document the existence of disparities — albeit with a slightly different twist — by looking at time trends.1–3 For most of the areas studied, disparities between white patients and black patients have not substantially improved during the past . . .
Subtle differences in CTL cytotoxicity determine susceptibility to hemophagocytic lymphohistiocytosis in mice and humans with Chediak-Higashi syndrome
Authors: Birthe Jessen, Andrea Maul-Pavicic, Heike Ufheil, Thomas Vraetz, Anselm Enders, Kai Lehmberg, Alfred Längler, Ute Gross-Wieltsch, Ali Bay, Zuhre Kaya, Yenan T. Bryceson, Ewa Koscielniak, Sherif Badawy, Graham Davies, Markus Hufnagel, Annette Schmitt-Graeff, Peter Aichele, Udo zur Stadt, Klaus Schwarz, Stephan Ehl
Journal: Blood (2011)
Gene expression profiling identifies emerging oncogenic pathways operating in extranodal NK/T-cell lymphoma, nasal type
Authors: Yenlin Huang, Aurélien de Reyniès, Laurence de Leval, Bouchra Ghazi, Nadine Martin-Garcia, Marion Travert, Jacques Bosq, Josette Brière, Barbara Petit, Emilie Thomas, Paul Coppo, Teresa Marafioti, Jean-François Emile, Marie-Hélène Delfau-Larue, Christian Schmitt, Philippe Gaulard
Journal: Blood (2009)
MAST-CELL DISEASE IN CHILDREN. Report of Eleven Cases.
Authors: E. M. BRETT, BEALE H. ONG, T. FRIEDMANN
Journal: British Journal of Dermatology (1967)

Journal Article MAST‐CELL DISEASE IN CHILDREN. Report of Eleven Cases. Get access E. M. BRETT, E. M. BRETT The Department of Pediatrics, Harvard Medical School, and the Department of Medicine, Children's Hospital Medical Center, Boston, Massachusetts Search for other works by this author on: Oxford Academic Google Scholar BEALE H. ONG, BEALE H. ONG The Department of Pediatrics, Harvard Medical School, and the Department of Medicine, Children's Hospital Medical Center, Boston, Massachusetts Search for other works by this author on: Oxford Academic Google Scholar T. FRIEDMANN T. FRIEDMANN The Department of Pediatrics, Harvard Medical School, and the Department of Medicine, Children's Hospital Medical Center, Boston, Massachusetts Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 79, Issue 4, 1 April 1967, Pages 197–208, https://doi.org/10.1111/j.1365-2133.1967.tb11476.x Published: 01 April 1967
Nasal mask pressure waveform and inspiratory muscle rest during nasal assisted ventilation.
Authors: V Jounieaux, V F Parreira, P Delguste, G Aubert, D O Rodenstein
Journal: American Journal of Respiratory and Critical Care Medicine (1997)

In mechanically ventilated patients, pressure and flow tracings can be used to assess respiratory pump muscle activity or rest. When the ventilation is delivered through an endotracheal tube, the respiratory system can be considered a one-compartment model, and activation of the respiratory muscles results in deformations and variability of the pressure tracings. This is also true when mechanical ventilation is delivered nasally. With intermittent positive-pressure ventilation delivered through a nasal mask (nIPPV), we have recently shown that the glottis can interfere with ventilation even in the absence of diaphragmatic surface electromyographic (EMG) activity. On the basis of our observations, we suggested that when mechanical ventilation is delivered through a nasal means of access, the respiratory system cannot be considered a one-compartment model. To confirm this hypothesis, we submitted one healthy subject to nIPPV while his glottis was continuously monitored through a fiberoptic bronchoscope and his diaphragmatic activity was monitored with a bipolar esophageal electrode. During wakefulness or sleep, we observed irregularities in the nasal mask pressure waveform, in nasal mask peak pressure, and in actual VT despite the absence of respiratory pump muscle activity. These irregularities were related to significant variations in the glottic width, rather than to the reappearance of transient phasic inspiratory muscle activity. We conclude that during nIPPV, deformations in the mask pressure waveform can be induced by variations in the glottic aperture without activation of the diaphragm. Thus, when mechanical ventilation does not bypass the glottis, the respiratory system does not behave like a one-compartment model, and EMG remains the only reliable technique for assessing diaphragmatic muscle activity.
Passive immunization against tumor necrosis factor-alpha impairs host defense during pneumococcal pneumonia in mice.
Authors: T van der Poll, C V Keogh, W A Buurman, S F Lowry
Journal: American Journal of Respiratory and Critical Care Medicine (1997)

Streptococcus pneumoniae is the most frequent cause of community-acquired pneumonia. We sought to determine the role of tumor necrosis factor-alpha (TNF) in the pathogenesis of pneumococcal pneumonia. Induction of pneumonia in C57B1/6 mice by intranasal inoculation with 10(6) colony-forming units (cfu) S. pneumoniae resulted in a sustained increase in TNF activity in lung homogenates reaching a plateau between 12 and 72 h (72 h: 185.49 +/- 54.41 ng/g), while plasma TNF activity remained low or undetectable. Treatment with a neutralizing anti-TNF monoclonal antibody 2 h before inoculation strongly reduced lung TNF activity, but only modestly diminished lung interleukin (IL)-1beta levels, and did not significantly influence lung IL-6, IL-10, and interferon-gamma concentrations. Anti-TNF-treated mice had fourfold more S. pneumoniae cfu isolated from lungs than control mice 40 h after inoculation (p < 0.05), although lung myeloperoxidase activities were similar in both treatment groups. Anti-TNF-treated mice died significantly earlier from pneumococcal pneumonia than control mice (p < 0.05). Endogenously produced TNF is important for host defense during pneumococcal pneumonia.
A 28-Year-Old Woman With Panic Disorder, 1 Year Later
Authors: Risa B. Burns
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 5757: A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers
Authors: Stephen M. Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Ezra E.W. Cohen, David N. Louis, Jeffrey Settleman, Daniel A. Haber
Journal: Cancer Research (2010)

Abstract In a genome-wide screen of 684 cancer cell lines, we identified homozygous intragenic microdeletions involving genes encoding components of the apical-basal cell polarity complexes. Among these, PARD3 is disrupted in cell lines and primary tumors from squamous carcinomas and glioblastomas. Reconstituting PARD3 expression in both cell types restores tight junctions and retards contactdependent proliferation. Searching specifically for small intragenic microdeletions using high resolution genomic arrays may be complementary to other genomic deletion screens and resequencing efforts in identifying new tumor suppressor genes. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 5757.
Ten-year experience with early angioplasty in 759 patients with acute myocardial infarction
Authors: Frits Bär, Jindra Vainer, Jeroen Stevenhagen, Kars Neven, Rob Aalbregt, Ton Oude Ophuis, Vincent van Ommen, Hans de Swart, Ebo de Muinck, Willem Dassen, Hein Wellens
Journal: Journal of the American College of Cardiology (2000)
EXPLOSION OF SILVER FULMINATE IN HISTOPATHOLOGIC LABORATORY
Authors: John Albert Marshall
Journal: JAMA (1930)

An explosion occurred Tuesday, March 11, which has jeopardized the eyesight of a research worker in one of the laboratories at the University of California. Sections of bone and teeth with their contained soft tissues had been stained by the so-called silver nitrate method.<sup>2</sup>The stender dishes containing the ammoniacal silver oxide solution were inadvertently left standing in the sun from Saturday noon until Tuesday morning. There were traces of alcohol in the silver solutions carried there by the sections of tissue. The sunlight hastened a chemical reaction between the silver, the ammonia and the alcohol and there resulted from it a highly explosive, very sensitive and unstable compound, silver fulminate (C=N-O-Ag), to be distinguished from the so-called fulminating silver, which explodes on drying. When the dish was taken up to be emptied and cleaned, it was warm from the sun. The mere movement of the liquid was responsible
IMPROVEMENT OF NEUROCOGNITIVE FUNCTION AFTER CAROTID ARTERY STENTING IN ASYMPTOMATIC SEVERE INTERNAL CAROTID OCCLUSIVE DISEASE WITH OBJECTIVE HEMISPHERE ISCHEMIA
Authors: Ying-Hsien Chen, Mao-Shin Lin, Ming-Jang Chiu, Hsien-Li Kao
Journal: Journal of the American College of Cardiology (2011)
Proton Magnetic Resonance Spectroscopy in Adults with Childhood Lead Exposure
Authors: Kim M. Cecil, Kim N. Dietrich, Mekibib Altaye, John C. Egelhoff, Diana M. Lindquist, Christopher J. Brubaker, Bruce P. Lanphear
Journal: Environmental Health Perspectives (2010)

Childhood lead exposure adversely affects neurodevelopment. However, few studies have examined changes in human brain metabolism that may underlie known adverse cognitive and behavioral outcomes. We examined the association between mean childhood blood lead levels and in vivo brain metabolite concentrations as adults, determined by proton magnetic resonance spectroscopy (MRS) in a birth cohort with documented low-to-moderate lead exposure. Adult participants from the Cincinnati Lead Study [n = 159; mean age (± SD), 20.8 ± 0.9 years] completed a quantitative, short-echo proton MRS protocol evaluating seven regions to determine brain concentrations of N-acetyl aspartate (NAA), creatine and phosphocreatine (Cr), cholines (Cho), myo-inositol, and a composite of glutamate and glutamine (GLX). Correlation and multiple linear regression analyses were conducted. Mean childhood blood lead levels were associated with regionally specific brain metabolite concentrations adjusted for age at imaging and Full-Scale intelligence quotient. Adjusted analyses estimated for a unit (micrograms per deciliter) increase in mean childhood blood lead concentrations, a decrease of NAA and Cr concentration levels in the basal ganglia, a decrease of NAA and a decrease of Cho concentration levels in the cerebellar hemisphere, a decrease of GLX concentration levels in vermis, a decrease of Cho and a decrease of GLX concentration levels in parietal white matter, and a decrease of Cho concentration levels in frontal white matter. Gray-matter NAA reductions associated with increasing childhood blood lead levels suggest that sustained childhood lead exposure produces an irreversible pattern of neuronal dysfunction, whereas associated white-matter choline declines indicate a permanent alteration to myelin architecture.
THE CYTOLOGY OF GONORRHEAL DISCHARGES.
Authors: ROBERT W. TAYLOR
Journal: JAMA (1907)

Within the past five or six years considerable attention has been directed to the study of the finer structural details, in other words, the cytology of the elements of the discharge of urethritis. This line of study, as well as the methods employed, is practically an application of the recent advances in the morphology of the blood. It is somewhat difficult to see what particular purpose this work subserves, for it has not helped us in understanding the nature of the process nor has it given any aid from a prognostic standpoint. And after reviewing the subject and supplementing it with some personal observations I have come to the conclusion that any clinical aid or therapeutic guidance from this whole line of work, although sustained by a large volume of literature, is of very doubtful value. It is not susceptible of practical application. I shall endeavor to lay the subject
Death and Identity
Authors: Marjorie C. Meehan
Journal: JAMA (1965)

Death and bereavement have led many authors to express their personal emotions. Only recently, however, have behavioral scientists investigated the variety of attitudes and reactions to grief and death. This book is a collection of such studies, with brief interpretative comments by the sociologist-editor. The excellence of most of the papers, their skillful arrangement, and the wide range of sources, all justify this compilation, which is not marred by the fragmentation, repetition, and unevenness of most "instant books." One might quibble about the title—the book says much about death, little about identity. Has "identity" been used because it is one of the fashionable words of the moment, like "seminal," "operational," "parameter," or "alienation"? The first paper, by Robert Lifton, reports on interviews in 1962, of those who survived the Hiroshima bombing. This overwhelming encounter with death produced lasting effects, including, often, hostility, a sense of new and unwanted identity, and,
PWE-058 Increasing Use Of Endoscopic Resection, Single-centre Experience
Authors: S Ansari, R Sood, V Hegade, L-A Smith
Journal: Gut (2014)

<h3>Introduction</h3> Endoscopic Resection (ER), a technique, first pioneered in Japan for treating early gastric cancers, has gained popularity globally. The delivery of an ER service requires specialist expertise and is therefore limited to a few centres in the UK. Here in Bradford, an ER service was established in 2007, and is delivered by a single operator. The aim of this study was to observe changes in our ER practice over time. <h3>Methods</h3> This was a prospective study of all patients who had undergone ER between August 2007 and December 2012 in Bradford Royal Infirmary. Patients were referred by experienced consultants, from the same trust or neighbouring hospitals, and were considered difficult cases, due to lesion size and/or access. Data from every ER case were recorded into a spreadsheet and divided into upper gastrointestinal (GI) ER or lower GI ER. We recorded patient demographics, lesion size and site, sedation, outcome, complications, and lesion removal (whole/piecemeal). Cases performed before 2010 (pre-2010) were separated from those performed in or after 2010 (post-2010). Data were analysed separately for the 2 time periods and then compared. <h3>Results</h3> There were a total of 245 ER cases over the study period (47 upper GI, and 198 lower GI). The number of upper GI ER cases increased from 15, pre-2010 to 32, post-2010. The success rate improved over time from 87 to 97% and the complication rate fell from 26 to 6%. Complications included 1 gastric perforation and 5 cases of minor bleeding treated endoscopically. The mean doses of Midazolam (2.5 mg) and Fentanyl (30 mcg) remained the same over time; however cases performed under general anaesthesia (GA) increased sharply from 7% to 37%. Mean polyp size also increased from 14 to 18 mm, although the distribution of polyps in the upper GI tract remained the same over time, with around 50% found in the stomach. Whole piece removal increased from 53% to 66%, despite increasing polyp size. The number of lower GI ER cases also increased substantially from 62, pre-2010, to 136, post-2010. Success rate improved from 92 to 95%, whilst the complication rate remained the same at 5%. Complications included 1 postpolypectomy syndrome and 6 cases of bleeding. Doses of Midazolam (1.5 mg) and Fentanyl (75 mcg) remained the same over time, and interestingly the use of GA in lower GI ER was considerably lower (&lt;1%) compared to upper GI cases. There were no changes in polyp size (26 mm), polyp distribution or whole piece removal (40%) over time. <h3>Conclusion</h3> Our results demonstrate an increasing use of ER for upper and lower GI lesions. Over time, and thus, with more experience the success rate and complication rate have improved. These results are in line with other studies, emphasising ER as a safe technique, which should be considered before surgery for managing large and difficult GI lesions. <h3>Disclosure of Interest</h3> None Declared.
Confusion reigns on staff grade, says report
Authors: C Court
Journal: BMJ (1994)

Staff grade doctors in Britain should be given more flexible educational opportunities so that those who work part time and have domestic commitments are still able to take part, according to a new report from the Standing Committee on Postgraduate Medical and Dental Education. The report says that 36% of women compared with 3% of men work part time and that these people seem to be losing out with respect to their educational needs. It …
Lifestyle and Cardiovascular Health
Authors: Véronique L. Roger
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Altered sympathetic tone plays an important role in arrhythmogenicity of radiofrequency catheter ablation of supraventricular tachycardia
Authors: Yasuya Inden, Naoya Tsuboi, Teruo Ito, Mamoru Ito, Yuklomi Tsuji, Takumi Yamada, Yukihiko Yoshida, Haruo Hirayama, Makoto Hirai, Hiroshi Hayashi
Journal: Journal of the American College of Cardiology (1996)
Prognosis of small hepatocellular carcinoma (less than 3 cm) after percutaneous acetic acid injection: Study of 91 cases
Authors: K Ohnishi
Journal: Hepatology (1996)

To assess the efficacy of ultrasound (US)-guided percutaneous acetic acid (in concentrations of 15%, 20%, 30%, 40%, and 50%) injection for small hepatocellular carcinomas (HCCs) for long-term prognosis, percutaneous acetic acid injection using 15% to 50% acetic acid was performed in 91 patients with one to four HCCs smaller than 3 cm during the past 6.5 years. During the series of treatment sessions for each patient, the same concentration of acetic acid was used. All tumors could be treated successfully with percutaneous acetic acid injection despite the differences in acetic acid concentration used. The number of treatment sessions to treat similar size of tumor was less when the higher concentration of acetic acid was used. No serious complications occurred as a direct sequela to percutaneous acetic acid injection. None of the tumor treated regrew. The 1-, 2-, 3-, 4-, and 5-year survival rates for 91 patients were 95%, 87%, 80%, 63%, and 49%, respectively. The 1-, 2-, 3-, 4-, and 5-year cancer-free survival rates of these patients were 83%, 54%, 50%, 37%, and 29%, respectively. Both liver function and size of tumor affected both survival rate and cancer-free survival rate significantly, but the number of tumors did not. The concentration of acetic acid did not affect the survival rate. Percutaneous acetic acid using 15% to 50% acetic acid will be effective therapy for small HCCs for long-term prognosis.
Cytochrome P17 Inhibition With Ketoconazole As Treatment for Advanced Granulosa Cell Ovarian Tumor
Authors: Jesus Garcia-Donas, Alicia Hurtado, Zaida García-Casado, Judith Albareda, Jóse Antonio López-Guerrero, Isabel Alemany, Enrique Grande, Juan Carlos Camara, Susana Hernando
Journal: Journal of Clinical Oncology (2013)

Originally published by the American Society of Clinical Oncology. Garcia-Donas et al.: Journal of Clinical Oncology Vol. 31.10, April 1 - 2013: e165-e166