tbuckley/cabot-search huggingface dataset:
DOES TERMINATION OF ATRIAL FIBRILLATION DURING ABLATION OF LONG STANDING PERSISTENT ATRIAL FIBRILLATION PREDICT THE OUTCOME AT FOLLOW-UP? RESULTS FROM A PROSPECTIVE RANDOMIZED STUDY
Authors: Luigi Di Biase, Pasquale Santangeli, Prasant Mohanty, Rong Bai, Rodney Horton, Javier Sanchez, Madhu Reddy, Dhanunjaya Lakkireddy, Giovanni Forleo, Sanghamitra Mohanty, Justin Price, Chintan Trivedi, Rachel (Xue) Yan, Claude Elayi, Joe Gallinghouse, Salwa Beheiry, Richard Hongo, John Burkhardt, Andrea Natale
Journal: Journal of the American College of Cardiology (2013)
Fibrous Dysplasia with Barely Increased Uptake on Bone Scan
Authors: JIMIN HAN, JIN-SOOK RYU, MYUNG JIN SHIN, GYEONG HOON KANG, HEE KYUNG LEE
Journal: Clinical Nuclear Medicine (2000)

Fibrous dysplasia, in general, appears as an area of markedly increased uptake on bone scintigraphy. Therefore, the possibility of fibrous dysplasia is likely to be excluded when the lesion shows no or slightly increased uptake. The authors report a case of incidentally detected fibrous dysplasia that appeared as slightly increased uptake on bone scintigraphy and was found to harbor a bone infarction along with typical fibrous dysplasia by pathologic examination of a specimen sampled by curettage. Barely increased bone uptake in fibrous dysplasia may be associated with decreased vascularity and osteoblast activity of the lesion as a result of concurrent bone infarction. The authors suggest that not every case of fibrous dysplasia appears as an area of intensely increased uptake on a bone scan. Clinicians should be cautious in interpreting bone scans of radiographically indicated fibrous dysplasia.
Antibiotics for cough and purulent sputum
Authors: N. C H Stott, R R West
Journal: BMJ (1978)

cachexia-inducing tumours are encountered in mice; a chemically induced cachexia-producing murine gastric carcinoma has been described previously.2It is suggested that the use of such tumours would avoid the complications underlying the system developed by Dr Strain and his colleagues-that is, xenografts of a human hypernephroma in immunodepressed mice.In the case of our tumours the effect of diet modification would seem to provide a valuable opening for experimental investiga- tions relevant to clinical cancer cachexia.
Functional defect of T cells in autoimmune gastritis.
Authors: J A Vargas, M Alvarez-Mon, L Manzano, A Albillos, A Fernandez-Corugedo, F Albarran, A Durantez
Journal: Gut (1995)

The functional response and phenotypic characterisation of peripheral blood T cells were studied in 41 patients with autoimmune gastritis--nine patients with autoimmune gastritis alone, 11 with untreated pernicious anaemia, and 21 with resolved pernicious anaemia who were taking vitamin B-12. Phenotypic analysis showed no changes in the CD4/CD8 ratio in any group of patients. CD3+ cells were significantly decreased and CD16+ cells were significantly increased in patients with autoimmune gastritis alone. Phytohaemagglutinin induced T cell proliferation, with or without interleukin 2, was reduced in the three groups. T cell proliferation induced by phorbol myristate acetate was normal. Interleukin 2 production of phytohaemagglutinin-stimulated lymphocytes was normal in the three groups. Five patients with pernicious anaemia treated with vitamin B-12 were followed and persistent hypoproliferation of T cells in response to phytohaemagglutinin was observed. The follow up study of the phenotype of these patients showed a significant increase of the CD2+ CD3- lymphocyte population after six months9 treatment. In conclusion, the three groups of autoimmune gastritis patients studied have a functional defect in T cells that is independent of B-12 treatment and of the presence of pernicious anaemia.
Heterozygous disruption of Hic1 predisposes mice to a gender-dependent spectrum of malignant tumors
Authors: Wen Yong Chen, Xiaobei Zeng, Mark G. Carter, Craig N. Morrell, Ray-Whay Chiu Yen, Manel Esteller, D. Neil Watkins, James G. Herman, Joseph L. Mankowski, Stephen B. Baylin
Journal: Nature Genetics (2003)
F-18 FDG Imaging of an Asymptomatic Sacrococcygeal Pilonidal Sinus in a Patient With Malignant Disease
Authors: Ílknur Ak
Journal: Clinical Nuclear Medicine (2007)

This case illustrates a pitfall associated with F-18 FDG imaging. We present the images of a 57-year-old woman with non-Hodgkin's lymphoma that shows intense accumulation of F-18 FDG in a sacrococcygeal pilonidal sinus that could indicate a lymphomatous involvement from a primary disease. MRI showed a well-defined sinus tract from skin to the sacrococcygeal region corresponding to the F-18 FDG uptake. She did not have any symptoms of a sacrococcygeal pilonidal sinus such as discharge, swelling or pain. There was no visible opening of the sinus tract on the skin. Pilonidal sinus is commonly a hair-containing sinus or abscess in the sacrococcygeal area. Hair acts as a foreign body causing an inflammatory reaction.
Incidental Detection of a Pulmonary Adenocarcinoma on Low-Dose Computed Tomography Used for Attenuation Correction in Myocardial Perfusion Imaging With SPECT
Authors: Lars Husmann, Fuminari Tatsugami, Ronny R. Buechel, Aju P. Pazhenkottil, Philipp A. Kaufmann
Journal: Clinical Nuclear Medicine (2010)

A 68-year-old patient with known 3-vessel coronary artery disease, a history of aortocoronary bypass surgery, and presently without chest pain, was referred to myocardial perfusion imaging for preoperative risk assessment as infrarenal aortic aneurysm repair was planned. Single photon emission computed tomography (CT) revealed normal myocardial perfusion at adenosine-stress and at rest. However, the CT scan used for attenuation correction (AC) demonstrated a large tumor in the right upper lung as an incidental finding, and the patient was referred for staging with F-18 fluorodeoxyglucose positron emission tomography/CT and subsequently to thoracic surgery. The lesion was resected and diagnosed to be an adenocarcinoma (stage pT2, cN0, cM0). When last seen, the patient was recovering well from surgery.
The "Chronic Rheumatic" and his Pains
Authors: P. Ellman, D. Shaw
Journal: Annals of the Rheumatic Diseases (1950)

Non-articular rheumatism embraces some 75 per cent. of cases of chronic rheumatic disorders, including fibrositis, muscular rheumatism, neuritis, panniculitis, capsulitis, pleurodynia, lumbago, and so on.The term " fibrositis " is applied to many maladies sharing a common symptomatology of pain, stiffness, and limi- tation of movement.The status of fibrositis with particular reference to the problem of differential diagnosis was reviewed by Ellman (1947).The multiple causes of backache, including psychological, have been dealt with by Cohen (1948).Valentine (1947) made a comprehensive review of the aetiological factors.Hurst (1943) declared that patients with " genuine " sciatica or lumbago usually recover in two or three weeks if given rest, and that pain persisting after this is almost always a result of hysterical perpetuation.In discussing the normal duration of lumbago or sciatica, presumably associated with internal muscle strains or exposure to cold or damp, Halliday (1944) states that, although the duration of pain of this type depends on the nature, degree, and locality of the trauma, it seems unlikely that it should continue over months or years; workers subjected to cold or wet surroundings or to draughts may continue symptomless for years, and if they report sick it is often at a time of some emotional disturbance usually associated with inward feelings of resentment.It has long been recognized that emotional factors play an important role; Halliday (1944) found that 30 per cent. of 145 consecutive patients labelled as having " rheumatism " were incapacitated because of psychoneurosis, and that " psychoneurotic rheumatism " accounted for 40 to 60 per cent. of those who remained on the sick list for two months or more.Ellman and others (1942), in a study of fifty "fibrositis " patients with a history of 3 months or more, made psychiatric diag- noses in 38 (76 per cent.).Flind and Barber (1945) found that in about 42 per cent. of patients admitted to R.A.F.special rheumatic centres the disability was essen- tially psychogenic.Such " psychogenic rheumatism " was the most frequent cause of disability (34 per cent.) in 450 soldiers with rheumatic complaints admitted to U.S. military hospitals (Boland and Corr, 1945).Hench and Boland (1946), in a review of rheumatic disorders affecting American soldiers in the second world war, claim that 15 to 20 per cent. of men admitted to special rheumatism centres were in fact suffering from " psychogenic rheumatism ".They stress the 341 copyright.
Platelet-derived growth factor stimulates mouse 3T3 cell mitogenesis and leukocyte chemotaxis through different structural determinants.
Authors: L T Williams, H N Antoniades, E J Goetzl
Journal: Journal of Clinical Investigation (1983)

Platelet-derived growth factor (PDGF) stimulates both proliferation of fibroblasts and chemotaxis of leukocytes. In this study we compared the mitogenic and chemotactic activities of native PDGF and reduced PDGF. Reduction of PDGF (Mr = 32,000) to its constituent polypeptides (Mr = 14,000 and 17,000) caused a loss of the ability to stimulate proliferation of Balb/c 3T3 cells. However, reduced PDGF retained virtually all of its activity as a chemotactic agent for human neutrophils and monocytes. A half-maximal chemotactic response to both native and reduced PDGF occurred at a concentration of approximately 0.08 nM for neutrophils and 0.1 nM for monocytes. The maximal chemotactic response to reduced PDGF was at least as great as the maximal response to native PDGF. Both native and reduced PDGF stimulated the release of the lysosomal enzyme, beta-glucosaminidase, from neutrophils with a half-maximal response at less than 0.1 nM. However, the net maximum release of this enzyme by PDGF (and reduced PDGF) was significantly less than that stimulated by a maximal concentration of the chemotactic peptide N-formyl-methionyl-leucyl-phenylalanine. These results indicate that different structural determinants are required for the proliferative response of 3T3 cells to PDGF and for the chemotactic response of leukocytes to PDGF.
FRUIT VESSELS, MOSQUITOES AND YELLOW FEVER.
Authors: EDMOND SOUCHON
Journal: JAMA (1903)

The subjects which are about to engage our attention have been under investigation for many months. They comprise the following points : 1. The scarcity of<i>Stegomyia fasciata</i>on non-infected fruit vessels from ports quarantined against yellow fever. 2. The scarcity of cases of yellow fever on fruit vessels from ports quarantined against yellow fever. 3. The impunity of intercourse with fruit vessels at the city wharf before the holds are fumigated. 4. The<i>Stegomyia fasciata</i>on non-infected fruit vessels from ports quarantined against yellow fever are not infected. 5. The improbability of stegomyia on infected fruit vessels becoming infected before arriving at the quarantine station. 6. The impossibility of mosquitoes on infected fruit vessls to carry yellow fever to the city before the arrival of the vessel at the city wharf. 7. The cases of yellow fever found on fruit vessels were infected ashore. <h3>I.—SCARCITY OF STEGOMYIA FASCIATA ON</h3>
Theophylline and Urinary Retention
Authors: MANOJ PRAKASH
Journal: Annals of Internal Medicine (1981)

Letters1 June 1981Theophylline and Urinary RetentionMANOJ PRAKASH, M.D., J. DENISE WASHBURNE, M.D.MANOJ PRAKASH, M.D.Search for more papers by this author, J. DENISE WASHBURNE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-94-6-823_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In response to, and in support of the brief report (1), "Theophylline Induced Urinary Retention" by Owens and Tannenbaum, we wish to report a case we recently saw.A 75-year-old man, had a 3-year history of extrinsic asthma controlled with Marax (130 mg theophylline per tablet; J.B. Roerig Pharmaceuticals, New York, New York), one tablet three times a day; prednisone 10 mg/d; and epinephrine used as needed. He was admitted having had symptoms of prostatism for several months. His prostate gland weighed approximately 30 g. On admission the serum theophylline level was 11.9 µg/mL. The patient had...References1. OWENSTANNENBAUM GR. Theophylline induced urinary retention. Ann Intern Med. 1981;94:212-3. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Thomas Jefferson University Hospital 111 South 11th Street; Philadelphia PA 19107 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1981Volume 94, Issue 6Page: 823-823KeywordsAsthmaEpinephrineProstate gland ePublished: 1 December 2008 Issue Published: 1 June 1981 PDF downloadLoading ...
Effects of increasing blood hemoglobin levels on systemic hemodynamics of acutely anemic cirrhotic patients
Authors: J.Ignasi Elizalde, Eduardo Moitinho, Joan Carles García-Pagán, Isabel Cirera, Angels Escorsell, Juan Carlos Bandi, Wladimiro Jiménez, Jaume Bosch, Josep M. Piqué, Joan Rodés
Journal: Journal of Hepatology (1998)
Linking in accessory pathways. Functional loss of antegrade preexcitation.
Authors: M D Gonzalez, A J Greenspon, G A Kidwell
Journal: Circulation (1991)

Concealed retrograde activation has been proposed as a mechanism for antegrade conduction block in the bundle branches and atrioventricular accessory pathways. We studied this hypothesis (linking) in 10 patients with the Wolff-Parkinson-White syndrome in whom antegrade preexcitation could be persistently blocked by overdrive atrial pacing.An atrial pacing protocol, with a decremental ramp followed by an incremental ramp, defined a range of atrial paced cycle lengths (linking window) associated with both persistent conduction and block in the accessory pathway. Within the limits of the linking window, the ability of an atrial impulse to conduct over the accessory pathway was dependent on the preceding state (i.e., conduction or block). The observed linking window ranged from 70 to 290 msec (mean, 185 +/- 68 msec) and closely approximated the measured delay in retrograde activation of the accessory pathway during persistent antegrade block. The mean antegrade effective refractory period of the accessory pathways was long (486 +/- 156 msec), and in each case, it exceeded the antegrade refractory period of the normal atrioventricular pathway. Critically timed premature ventricular extrastimuli, delivered while linking was maintained in the accessory pathway, were able to interrupt the linking and restore antegrade accessory pathway conduction.These observations suggest that accessory pathway linking is associated with bidirectional block in the accessory pathway. The ability to initiate linking (and the stability of the phenomenon) depends on a critical relation between antegrade accessory pathway refractoriness and the magnitude of retrograde accessory pathway activation delay.
Cardiac Responses to Sympathetic Stimulation
Authors: JORGE ANZOLA, ROBERT F. RUSHMER
Journal: Circulation Research (1956)

The cardiac responses to stimulation of sympathetic nerves to the heart were studied both in thoracotomized and in intact unanesthetized dogs. The changes in heart rate, left ventricular pressure, right and left ventricular dimensions and systemic arterial pressures were recorded. The powerful effects of sympathetic stimulation resemble cardiac responses to exercise more than those following administration of catecholamines. It is inferred that neural mechanisms may be more important for cardiac control during spontaneous activities than the circulating hormones.
Nasal and Bronchial Challenge Test with Profilin (Pho d 2) in Patients with Rhinitis and Asthma Sensitized to Pollen
Authors: M. Garcia del Potro, D. Lumelli, M. Fernandez-Nieto, E. Hernandez, D. Barber, J. Sastre
Journal: Journal of Allergy and Clinical Immunology (2010)
Treatment of a Unique Anemia in Patients With IDDM With Epoetin Alfa
Authors: Mark U Rarick, Byron M Espina, Daniel T Colley, Aaron Chrusoskie, Shannan Gandara, Donald I Feinstein
Journal: Diabetes Care (1998)

OBJECTIVE To identify and treat a unique form of anemia in patients with long-term IDDM. RESEARCH DESIGN AND METHODS Patients with IDDM, unexplained symptomatic anemia, and serum creatinine levels of &amp;lt; 177 μmol/l (2.0 mg/dl) were treated with epoetin alfa (Procrit, Ortho Biotech, Raritan, NJ), 50 U/kg three times weekly, subcutaneously, to reach a target hematocrit of 38–40%. Baseline serum erythropoietin titers were measured before drug therapy. RESULTS Six patients were treated with epoetin alfa. Median age of the group was 74 years, with IDDM being diagnosed for a median of &amp;gt; 20 years. All patients had symptoms of anemia with a median hematocrit of 28.9% (range 27–31). Compared with iron deficiency control patients, the group had a limited erythropoietin (EPO) response to the degree of anemia. All patients showed increases in hematocrit, median peak of 40.9%, with median time-to-peak response of 12 weeks. Baseline symptoms of anemia resolved in all patients. No adverse effects were noted during the treatment period. CONCLUSIONS There is a unique form of anemia in patients with long-term IDDM and clinically normal renal function who respond to low-dose epoetin alfa therapy. The rapid response to therapy and depressed baseline erythropoietin titers suggest the anemia is due to a lack of endogenous EPO release.
Diabetic cheiroarthropathy in adult non-insulin-dependent diabetes.
Authors: P Rossi, V Fossaluzza
Journal: Annals of the Rheumatic Diseases (1985)

Arthritis of the middle ear in ankylosing spondylitis SIR, We have read with interest the paper by Magaro, Ceresia, and Frustaci on arthritis of the middle ear in ankylosing spondylitis
Endoscopic Removal of Choriocarcinoma Metastasis in a Patient with Chronic Intestinal Hemorrhage
Authors: S. Meryn, R. Pötzi, W. Graninger, T. Egger, K. Pirich, N. Neuhold
Journal: Endoscopy (1983)

A case of teratoma and choriocarcinoma of the testis with a single metastasis to the jejunum is described. The patient had suffered from severe intestinal hemorrhage for several weeks. An uneventful endoscopic removal of the metastasis was performed. The report illustrates that, particularly in young patients, metastatic lesion of the small bowel should be considered a possible cause of intestinal bleeding in patients who have neoplasm.
Incidence, risk factors, and outcomes of sclerosis in patients with chronic graft-versus-host disease
Authors: Yoshihiro Inamoto, Barry E. Storer, Effie W. Petersdorf, J. Lee Nelson, Stephanie J. Lee, Paul A. Carpenter, Brenda M. Sandmaier, John A. Hansen, Paul J. Martin, Mary E. D. Flowers
Journal: Blood (2013)
Oestrogens in Oophorectomized Women
Authors: E. Schleyer-Saunders
Journal: BMJ (1971)

Comments are made on an article by S. Gow and I.  MacGillivray who reported that 16% of 25 women who underwent a hysterectomy and bilateral salpingo-oophorectomy developed venous thrombosis after treatment with estrogen.  The writer notes that the number treated was too small to be used  for statistical purposes and that the 4 cases who developed venous thrombosis had other predisposing causes.  In the writers own review of 1000 menopausal women treated with implants of estradiol progesterone and testosterone the incidence of uterine bleeding and cancer of the uterus and breast was lower in the treated women than in the untreated  women.  It is recommended that menopausal women not be deprived of the benefits derived from hormonal treatment.
IMPACT OF PIOGLITAZONE ON CORONARY ATHEROSCLEROSIS IN PATIENTS WITH NON- AND EARLY-DIABETES: A PROSPECTIVE RANDOMIZED STUDY WITH INTRAVASCULAR ULTRASOUND
Authors: Nobuyuki Komiyama, Toshihiko Kikutani, Tomomi Koizumi, Tohru Tamaki, Tetsuro Yamazaki, Atsushi Sakamato, Eiji Takagi, Shigeyuki Nishimura
Journal: Journal of the American College of Cardiology (2010)
AN EPIDEMIC OF COCCIDIOIDAL INFECTION (COCCIDIOIDOMYCOSIS)
Authors: BURT L. DAVIS
Journal: JAMA (1942)

An epidemic of coccidioidal infection would have been inconceivable five years ago. Then the usually fatal coccidioidal granuloma was the only recognized form of infection by Coccidioides immitis. During 1936-1938 Gifford<sup>1</sup>and Dickson<sup>2</sup>proved that this fungus more frequently produces mild infections. Many of us are still conditioned by the former conception of coccidioidomycosis as a deadly disease. We hope that the record of this small epidemic will emphasize the frequency and usually benign character of coccidioidal infection in its endemic areas. These endemic regions are, like the site of our small epidemic, semiarid with hot, dry and dusty summers and autumns. The most publicized is the San Joaquin Valley, the southern component of the great central valley, of California. Other parts of southern California, Arizona, Texas and probably New Mexico and Mexico are endemic centers. Sporadic cases have been reported elsewhere in North America and Europe. The
819 THE BASIC LEUCINE ZIPPER MOTIF OF THE HEPATITIS C VIRUS NONSTRUCTURAL PROTEIN 4B IS ESSENTIAL FOR REPLICATION EFFICACY IN A GENOTYPE IB REPLICÓN MODEL
Authors: M. Welker, S. Susser, C. Welsch, C. Fueller, B. Kronenberger, S. Zeuzem, C. Sarrazin
Journal: Journal of Hepatology (2011)
Health secretary cuts number of targets in a move to local health plans
Authors: Madeline Brettingham
Journal: BMJ (2004)

The next stage of NHS reform will be driven by local planning rather than national targets, according to the secretary of state for health, John Reid, who last week launched the government's latest three year plan for the health service.

The document sets out the guidelines by which all organisations in the NHS will be expected to implement the June 2004 NHS Improvement Plan. The emphasis is on local autonomy and care of individual patients. National targets, previously a keystone of government healthcare policy, have been cut by more than half, from 62 to 20.

Mr Reid stressed that the aim of the …
Book Review Can We Say No? The Challenge of Rationing Health Care By Henry J. Aaron and William B. Schwartz, with Melissa A. Cox. 199 pp. Washington, D.C., Brookings Institution Press, 2005. $44.95 (cloth); $18.95 (paper). 0-8157-0120-9 (cloth); 0-8157-0121-7 (paper).
Authors: Emmett Keeler
Journal: New England Journal of Medicine (2006)
Sydenham's Chorea-Reply
Authors: Susan E. Swedo
Journal: JAMA (1995)

<h3>In Reply.</h3> —Because of the potential for controversy about the utility of Sydenham's chorea as an etiologic model for childhood-onset obsessive-compulsive disorder and Gilles de la Tourette's syndrome, I was surprised and pleased that the concerns raised did not address this issue, but rather the details of the case report. I appreciate the careful consideration given to the article by Dr Jeret and Dr Jaffe, and I also appreciate the opportunity to clarify the Grand Rounds presentation. As pointed out by Jeret, the EEG findings in the case report were condensed in a confusing fashion. The pertinent portion of the original EEG report reads as follows: "mildly abnormal and consistent with Sydenham's chorea" because of the presence (during wakefulness) of "a background consisting of an irregular rhythm bilaterally which has a maximum frequency of 9 Hz; intermixed, there are many slow waves of 4-5 Hz frequency and 20-40 microvolts in