tbuckley/cabot-search huggingface dataset:
Kindler syndrome complicated by squamous cell carcinoma of the hard palate: successful treatment with high-dose radiation therapy and granulocyte-macrophage colony-stimulating factor
Authors: M. Lotem, M. Raben, R. Zeltser, M. Landau, M. Sela, M. Wygoda, Z.A. Tochner
Journal: British Journal of Dermatology (2001)

Journal Article Kindler syndrome complicated by squamous cell carcinoma of the hard palate: successful treatment with high‐dose radiation therapy and granulocyte–macrophage colony‐stimulating factor Get access M. Lotem, M. Lotem Departments of Oncology,Dermatology, Search for other works by this author on: Oxford Academic Google Scholar M. Raben, M. Raben Departments of Oncology, Search for other works by this author on: Oxford Academic Google Scholar R. Zeltser, R. Zeltser Maxillo‐Facial Surgery and Search for other works by this author on: Oxford Academic Google Scholar M. Landau, M. Landau Department of Dermatology, Tel Aviv Medical Center, Tel Aviv , Israel. Correspondence: E‐mail: lotem@isdn.net.il Search for other works by this author on: Oxford Academic Google Scholar M. Sela, M. Sela Maxillo‐Facial Rehabilitation, Hadassah University Hospital, PO Box 12000, 91120 Jerusalem, Israel Search for other works by this author on: Oxford Academic Google Scholar M. Wygoda, M. Wygoda Departments of Oncology, Search for other works by this author on: Oxford Academic Google Scholar Z.A. Tochner Z.A. Tochner Departments of Oncology, Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 144, Issue 6, 1 June 2001, Pages 1284–1286, https://doi.org/10.1046/j.1365-2133.2001.04262.x Published: 01 June 2001
Prevalent Vertebral Fracture and the Risk of Incident Vertebral Fracture
Authors: Akira Taguchi
Journal: JAMA (2008)

To the Editor: In their study of long-term risk of incident vertebral fractures, Dr Cauley and colleagues concluded that older women with a prevalent vertebral fracture had a substantially increased absolute risk of an incident fracture, particularly if they had osteoporosis diagnosed by bone mineral density assessment. In this study, it appears that both symptomatic and asymptomatic women with a prevalent vertebral fracture at baseline were combined. Only about one-third of vertebral fractures are clinically recognized. Because of this, it would be valuable to know the absolute risk of an incident fracture for symptomatic and asymptomatic women separately. Symptomatic women with a prevalent fracture at baseline may have had more opportunity to receive medication for osteoporosis than asymptomatic women who were diagnosed only by radiographs. This might result in a lower absolute risk of incident fracture among symptomatic women. In addition, the odds ratio (OR) for incident fracture in asymptomatic women with a prevalent fracture at baseline compared with those without a prevalent fracture might be higher than the overall risk reported in the study (OR, 4.21; 95% confidence interval, 3.33-5.34).
Echocardiographic and Electrocardiographic Diagnoses of Left Ventricular Hypertrophy Predict Mortality Independently of Each Other in a Population of Elderly Men
Authors: Johan Sundström, Lars Lind, Johan Ärnlöv, Björn Zethelius, Bertil Andrén, Hans O. Lithell
Journal: Circulation (2001)

Background —The increased risk associated with left ventricular hypertrophy (LVH) diagnosed echocardiographically (Echo-LVH) or electrocardiographically (ECG-LVH) is well known, but the clinically relevant question of how much additional prognostic information would be provided by echocardiographically assessing LVH if a subject’s ECG-LVH and hypertension status are known has not been addressed. Methods and Results —We investigated whether Echo-LVH and ECG-LVH predicted total and cardiovascular mortality and morbidity independently of each other and of other cardiovascular risk factors by using a population-based sample of 475 men investigated at age 70 with a median follow-up time of 5.2 years. Echocardiographic left ventricular mass index (LVMI) predicted total mortality (hazards ratio [HR] 1.44, 95% CI 1.09 to 1.92, for a 1-SD increase in LVMI) and cardiovascular mortality (HR 2.38, 95% CI 1.52 to 3.73) independently of ECG-LVH and other cardiovascular risk factors. ECG-LVH, defined as Cornell product &gt;244 μV · s, predicted total mortality (HR 2.89, 95% CI 1.41 to 5.96) independently of LVMI and other cardiovascular risk factors. Thus, Echo-LVH and ECG-LVH provided complementary prognostic information, especially in hypertensive subjects. Conclusions —Echo-LVH and ECG-LVH predict mortality independently of each other and of other cardiovascular risk factors, implying that Echo-LVH and ECG-LVH in part carry different prognostic information. Therefore, to fully assess the increased risk associated with these conditions, both ECG and echocardiography should be performed.
Silent hepatitis E virus infection in Dutch blood donors, 2011 to 2012
Authors: E Slot, B M Hogema, A Riezebos-Brilman, T M Kok, M Molier, H L Zaaijer
Journal: Eurosurveillance (2013)

In Europe, the dynamics of endemic hepatitis E virus (HEV) infection remain enigmatic. We studied the presence of silent HEV infection among Dutch blood donors. Using donations collected throughout the Netherlands in 2011 and 2012, 40,176 donations were tested for HEV RNA in 459 pools of 48 or 480 donations. Deconstruction of the reactive pools identified 13 viraemic donors. In addition, 5,239 donors were tested for presence of anti-HEV IgG and IgM and for HEV RNA when IgM-positive. Of the 5,239 donations, 1,401 (27%) tested repeat-positive for HEV IgG, of which 49 (3.5%) also tested positive for anti-HEV IgM. Four of the HEV IgM-positive donors tested positive for HEV RNA. HEV IgG seroprevalence ranged from 13% among donors younger than 30 years to 43% in donors older than 60 years. The finding of 17 HEV RNA-positive donations among 45,415 donations corresponds to one HEV-positive blood donation per day in the Netherlands. For 16 of the 17 HEV RNA-positive donors, genotyping succeeded, revealing HEV genotype 3, which is circulating among Dutch pigs. Apparently, silent HEV infection is common in the Netherlands, which possibly applies to larger parts of Europe.
Rheumatoid Arthritis
Authors: Shaun Ruddy, Harvey R. Colten
Journal: New England Journal of Medicine (1974)

Synthesis of complement components C2, C3, C4 and C5 by rheumatoid synovial tissue was demonstrated by three independent technics: in vivo metabolic studies with Radio-labeled C3; in vitro biosynthesis of C2, C3, C4 and C5; and staining of cells in rheumatoid synovium with fluorescent antiserums to C3 and C4. Production of complement components was more frequently observed with cultures of tissue obtained from patients with rheumatoid arthritis than with those from patients with degenerative or traumatic arthritis. The findings demonstrate the importance of local production of components of the inflammatory response in rheumatoid arthritis. (N Engl J Med 290:1284–1288, 1974)
Enhanced liver progenitor cell survival and differentiation in vivo by spheroid implantation in a vascularized tissue engineering chamber
Authors: Kiryu K. Yap, Aaron M. Dingle, Jason A. Palmer, Raminder S. Dhillon, Zerina Lokmic, Anthony J. Penington, George C. Yeoh, Wayne A. Morrison, Geraldine M. Mitchell
Journal: Biomaterials (2013)
Concepts of metastasis in flux: The stromal progression model
Authors: Jonathan P. Sleeman, Gerhard Christofori, Riccardo Fodde, John G. Collard, Geert Berx, Charles Decraene, Curzio Rüegg
Journal: Seminars in Cancer Biology (2012)

The ability of tumor cells to leave a primary tumor, to disseminate through the body, and to ultimately seed new secondary tumors is universally agreed to be the basis for metastasis formation. An accurate description of the cellular and molecular mechanisms that underlie this multistep process would greatly facilitate the rational development of therapies that effectively allow metastatic disease to be controlled and treated. A number of disparate and sometimes conflicting hypotheses and models have been suggested to explain various aspects of the process, and no single concept explains the mechanism of metastasis in its entirety or encompasses all observations and experimental findings. The exciting progress made in metastasis research in recent years has refined existing ideas, as well as giving rise to new ones. In this review we survey some of the main theories that currently exist in the field, and show that significant convergence is emerging, allowing a synthesis of several models to give a more comprehensive overview of the process of metastasis. As a result we postulate a stromal progression model of metastasis. In this model, progressive modification of the tumor microenvironment is equally as important as genetic and epigenetic changes in tumor cells during primary tumor progression. Mutual regulatory interactions between stroma and tumor cells modify the stemness of the cells that drive tumor growth, in a manner that involves epithelial-mesenchymal and mesenchymal-epithelial-like transitions. Similar interactions need to be recapitulated at secondary sites for metastases to grow. Early disseminating tumor cells can progress at the secondary site in parallel to the primary tumor, both in terms of genetic changes, as well as progressive development of a metastatic stroma. Although this model brings together many ideas in the field, there remain nevertheless a number of major open questions, underscoring the need for further research to fully understand metastasis, and thereby identify new and effective ways of treating metastatic disease.
Thalidomide victims win review of compensation
Authors: B Christie
Journal: BMJ (1994)

A review is to be conducted in Britain into the needs of victims of the thalidomide tragedy after a campaign to secure better compensation. Three people who were born severely deformed after their mothers took the drug in the early 1960s have staged hunger strikes recently, claiming that they have been forced into financial hardship. They say that the compensation arrangements worked out in 1973 with Distillers Co, the company that marketed the drug in Britain, have failed to provide for their long term needs.

The three people, all members of the Thalidomide Action Group based in Liverpool, are angry that the …
Single-blind comparative trial of trimethoprim-sulphamethoxazole and ampicillin in the treatment of exacerbations of chronic bronchitis
Authors: D. T. D. Hughes
Journal: BMJ (1969)

Fifty patients with exacerbations of chronic bronchitis were treated with either a combination of trimethoprim 320 mg. and sulphamethoxazole 1,600 mg. a day or ampicillin 2 g. a day. The trial, carried out as a single-blind procedure, showed that the combination was more effective as judged by clinical response and reduction in sputum volume and purulence, with eradication of pathogenic organisms. No appreciable side-effects were encountered with either treatment, and it is suggested that the trimethoprim-sulphamethoxazole combination may be a safe and useful drug in the treatment of chronic bronchitis.
Rupture of the uterus during prostaglandin-induced abortion.
Authors: G J Jarvis, D A Johnson, S Emery
Journal: BMJ (1979)

diseases.Also, in the light of past investigations, I agree that all patients on psychotropic drugs should be warned that their driving might be adversely affected by their drugs and that this effect can be aggravated by alcohol.If all medical practitioners give this warning and all patients heed it, we are going to find it even more difficult to carry out the randomised control trial that is so badly needed.
George S. Huntington, Anatomist
Authors: Leslie B. Arey
Journal: JAMA (1967)

To the Editor:—  An interesting editorial ( 197 :656, 1966) brings back memories, because Professor Huntington was one of the revered oldsters in the American Association of Anatomists when I began attending before World War I. The association was relatively small then, and its programs were all joint-session affairs. He would learnedly discuss many of the papers given. Huntington and McClure (of Princeton), singly and jointly, over a period of years bested the Johns Hopkins group on the origin of the lymphatic. This defeat, which Miss Sabin and her cohorts fought to the last ditch, broke the prevailing Hopkins prestige as the infallible source of all anatomical truth.  Dr. Huntington was not the first full-time professor of anatomy in America. Dr. Titus DeVille, an accomplished British anatomist, then living in Paris and sponsored by Brown-Sequard, filled the post of professor of descriptive anatomy at the start of the medical department of
Perspectives in Iron Metabolism
Authors: C. A. Finch, H. Huebers
Journal: New England Journal of Medicine (1982)

IN early times the earth had a reducing atmosphere, and an abundance of ferrous iron was present for incorporation into biologic molecules.1 Later, with an increase in atmospheric oxygen, iron existed largely in its less available ferric form,2 and special devices had to be developed by life forms for the acquisition of iron. Bacteria, for example, synthesize and excrete high-affinity chelating agents that extract otherwise unavailable iron from the surrounding environment.3 The roots of plants also secrete substances that augment iron absorption.4 In mammalian species a "shuttle" protein in the upper intestine — mucosal transferrin — appears to perform this . . .
Treatment of small hepatocellular carcinoma in cirrhotic patients: A cohort study comparing surgical resection and percutaneous ethanol injection
Authors: Antoni Castells, Jordi Bruix, Concepció Bru, Josep Fuster, Ramon Vilana, Miquel Navasa, Carmen Ayuso, Loreto Boix, Josep Visa, Joan Rodés
Journal: Hepatology (1993)

This study was intended to compare the survival rates of two contemporary cohorts of patients with solitary hepatocellular carcinomas < or = 4 cm subjected to surgical resection (n = 33) or percutaneous ethanol injection (n = 30). Outcomes in a third cohort, 21 patients with hepatocellular carcinoma who underwent orthotopic liver transplantation, were also assessed. Surgical and ethanol-treated patients were similar with regard to age and tumor stage, differing only in liver function; 30 of the 33 surgical patients were of Child-Pugh class A, whereas only 7 of the 30 ethanol-treated patients were of class A (p < 0.05). Surgical resection was successful in 30 cases; ethanol injection achieved initial success in 23 patients. Tumor recurrence rate at 2 yr was 45% in the surgical group and 66% in the ethanol group. The difference was significant only for cases with tumors between 3 and 4 cm. Despite poorer liver function, the 1-, 2-, 3- and 4-yr survival rates of ethanol-treated patients (83%, 66%, 55% and 34%, respectively) were not different from those of surgically treated patients (81%, 73%, 44% and 44%, respectively). The 1- and 2-yr survival rates of patients given liver transplants were 81% and 66%, without tumor recurrence, after 16-mo follow-up. These data confirm that ethanol injection is a useful treatment for patients with solitary small hepatocellular carcinomas and suggest that surgical resection and liver transplantation may achieve better results only after strict candidate selection to reduce mortality and tumor recurrence during follow-up.
Prognostic significance of FLT3 internal tandem repeat in patients with de novo acute myeloid leukemia treated with reinforced courses of chemotherapy
Authors: N Boissel, JM Cayuela, C Preudhomme, X Thomas, N Grardel, X Fund, I Tigaud, E Raffoux, P Rousselot, F Sigaux, L Degos, S Castaigne, P Fenaux, H Dombret
Journal: Leukemia (2002)
A RANDOMIZED OPEN-LABEL 2-PERIOD CROSSOVER DESIGN STUDY TO ASSESS THE STEADY-STATE EFFECTS OF DEXLANSOPRAZOLE LANSOPRAZOLE ESOMEPRAZOLE OR OMEPRAZOLE ON THE PHARMACOKINETICS AND PHARMACODYNAMICS OF CLOPIDOGREL IN HEALTHY SUBJECTS
Authors: Andrew L. Frelinger, Ronald D. Lee, Darcy J. Mulford, Jingtao Wu, Deepak L. Bhatt, Alan D. Michelson
Journal: Journal of the American College of Cardiology (2011)
Minocycline: stain devil?
Authors: M.L. Good, D.L. Hussey
Journal: British Journal of Dermatology (2003)

Summary Minocycline is the treatment of choice for acne vulgaris, the most common form of inflammatory acne, despite the increase in awareness of rare but significant side-effects. This paper discusses the undesirable side-effect of minocycline staining in permanent teeth.
Transient and Persistent Atrial Standstill with His Bundle Lesions
Authors: KENNETH M. ROSEN, SHAHBUDIN H. RAHIMTOOLA, ROLF M. GUNNAR, MAURICE LEV
Journal: Circulation (1971)

Electrophysiologic studies, including His bundle recording and atrial pacing (AP), were performed in one patient with transient (TAS) and another with persistent atrial standstill (PAS). Both subsequently expired, and postmortem examinations with serial sections of the conduction system were obtained. The patient with TAS had left bundle-branch (LBB) block, a P-H interval of 140 msec (normal, 80-140 msec), an H-Q of 40 msec (normal, 35-55 msec), and an AP threshold of 1.2 ma. Postmortem examination revealed total left circumflex occlusion proximal to the sinoatrial (SA) nodal artery takeoff, SA nodal arteriolosclerosis without infarction, and left-sided cardiac skeletal sclerosis (LSCSS) disrupting the penetrating portion of the His bundle and the LBB. Intracardiac recordings in the patient with PAS showed absent atrial activity and an H-Q of 60 msec. The atria were inexcitable with AP up to 15 ma at multiple sites. Postmortem examination revealed a previously undescribed atrial disease characterized by arteriolosclerosis, fibroelastosis, fatty infiltration, and vacuolar degeneration of muscle cells, with only moderate SA and A-V nodal involvement. LSCSS was present, disrupting the branching portion of the His bundle. Thus, TAS reflected SA nodal ischemia without infarction; PAS reflected a new atrial degenerative disease; H-Q was normal with a lesion in the penetrating portion of the His bundle and was prolonged with a similar lesion in the branching portion.
Pharmacotherapy of Neurally Mediated Syncope
Authors: David G. Benditt, Gerard J. Fahy, Keith G. Lurie, Scott Sakaguchi, William Fabian, Nemer Samniah
Journal: Circulation (1999)

Abstract —A wide variety of pharmacological agents are currently used for prevention of recurrent neurally mediated syncope, especially the vasovagal faint. None, however, have unequivocally proven long-term effectiveness based on adequate randomized clinical trials. At the present time, β-adrenergic receptor blockade, along with agents that increase central volume (eg, fludrocortisone, electrolyte-containing beverages), appear to be favored treatment options. The antiarrhythmic agent disopyramide and various serotonin reuptake blockers have also been reported to be beneficial. Finally, vasoconstrictor agents such as midodrine offer promise and remain the subject of clinical study. Ultimately, though, detailed study of the pathophysiology of these syncopal disorders and more aggressive pursuit of carefully designed placebo-controlled treatment studies are essential if pharmacological prevention of recurrent neurally mediated syncope is to be placed on a firm foundation.
Safety and Efficacy of Endoscopic Mucosal Therapy With Radiofrequency Ablation for Patients With Neoplastic Barrett's Esophagus
Authors: William J. Bulsiewicz, Hannah P. Kim, Evan S. Dellon, Cary C. Cotton, Sarina Pasricha, Ryan D. Madanick, Melissa B. Spacek, Susan E. Bream, Xiaoxin Chen, Roy C. Orlando, Nicholas J. Shaheen
Journal: Clinical Gastroenterology and Hepatology (2012)
Human herpes-virus 8 seropositive patient with skin and graft Kaposi’s sarcoma after lung transplantation
Authors: Evelyn M. Sachsenberg-Studer, Nicolas Dobrynski, Julie Sheldon, Thomas F. Schulz, Marc Pechère, Roland G. Nador, Anastase Spiliopoulos, Laurent Nicod, Jean-Hilaire Saurat
Journal: Journal of the American Academy of Dermatology (1999)
The Legacy of Harvey Cushing: Profiles of Patient Care
Authors: Ian Ross
Journal: JAMA (2007)

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Recent developments in Bell's palsy: Authors' response
Authors: Graeme M Weiner, N Julian Holland
Journal: BMJ (2004)

EDITOR—Most patients with Bell's palsy clearly do well with or without treatment. Outside certain patient subgroups, identifying who will fare well and who won't remains impossible. Therefore if treatment is to be given, all who are eligible for treatment must be treated for the benefit of the few. Although systematic reviews do not show statistically significant benefits, they are …
How to read a forest plot
Authors: P. Sedgwick
Journal: BMJ (2012)

Researchers undertook a meta-analysis of the safety and efficacy of antibiotic treatment compared with appendicectomy for the primary treatment of uncomplicated acute appendicitis. Randomised controlled trials were included if they investigated adult patients presenting with uncomplicated acute appendicitis, diagnosed by haematological and radiological investigations. The primary outcome measure was the presence of complications, including wound infection, perforated appendicitis, or peritonitis. Four randomised controlled trials were identified.1 The results of the meta-analysis for complications were presented in a forest plot.⇓



Antibiotic treatment versus appendicectomy for uncomplicated acute appendicitis: forest plot for complications



Which of the following statements, if any, are true?

Statements a , c , d , and e are all true, whereas b is false.

Four randomised controlled trials were identified that compared antibiotic treatment with appendicectomy for the treatment of uncomplicated acute appendicitis. The primary outcome in each trial was complications. For each trial a relative risk was derived that compared the risk of complications for antibiotic treatment relative to appendicectomy. Relative risk has been described in previous questions.2 3 Each sample relative risk was an estimate of the population parameter—that is, the relative risk that would be observed if antibiotic treatment was compared with appendicectomy for the entire population of all adults with uncomplicated acute appendicitis. The purpose of the meta-analysis was …