tbuckley/cabot-search huggingface dataset:
Central Airway Obstruction
Authors: Charles G. Spivey
Journal: JAMA (1973)

Seven patients had central airway obstruction of varied causes. The diagnosis was established early in some, but in others, because of either atypical clinical or physiological features or the lack of suspicion, the diagnosis was delayed. These cases emphasize that central airway obstruction may simulate asthma or chronic obstructive pulmonary disease and is not a rare clinical problem. Prime suspects are patients with dyspnea and wheezing without a well-defined cause.
Detection and Quantitation of <i>Dermatophagoides</i> Antigens in House Dust by Immunochemical Techniques
Authors: P. Lind, J. Korsgaard, H. Løwenstein
Journal: Allergy (1979)

Rabbit antibodies against D. pteronyssinus whole culture extract were rendered specific to mite antigens by immunoabsorption with extract of human dander. Using the absorbed antibodies, an extract of a mite culture gave rise to 15 peaks in crossed immunoelectrophoresis and to a titer of 512 in counter‐immunoelectrophoresis. When applied to dust samples from the homes of allergic patients, counter‐immunoelectrophoresis gave reproducible results within an error of 1 titer‐step. Mite antigens were detected in 64% of 105 dust samples investigated. The titer correlated well ( P &lt;0.005) with the concentration of Dermatophagoides bodies, found in 13 mattress dust samples by microscopy. Advantages and limitations of immunochemical quantitations of house dust mites in dust samples is discussed in relation to investigations by microscopy.
MOBILIZATION OF OCT-4&amp;plus; VERY SMALL EMBRYONIC LIKE STEM CELLS, HEMATOPOIETIC STEM CELLS AND ENDOTHELIAL PROGENITOR CELLS IN CHILDREN WITH CONGENITAL HEART DISEASE UNDERGOING CARDIAC SURGERY
Authors: Wojciech Wojakowski, Kolcz Jacek, Zuba-Surma Ewa, Drukala Justyna, Mariusz Ratajczak, Michal Tendera, Janusz Skalski
Journal: Journal of the American College of Cardiology (2012)
Determining the size of a total purchasing site to manage the financial risks of rare costly referrals: computer simulation model
Authors: M. O Bachmann, G. Bevan
Journal: BMJ (1996)

To estimate the financial risks of 15 categories of rare costly referrals for total purchasing sites of different population sizes.Computer simulation of 100 fund years assuming Poisson distribution of referrals.British general practices that have opted to become total purchasing sites. Referral rates and price estimates were supplied by South and West Devon Health Commission.Variation in referral costs to purchasers in relation to size of risk pool (person years at risk).Random variation in referral costs increased as the size of the risk pool decreased. Variation increased greatly below 30,000 person years. The mean simulated cost of the referral categories considered was 2.8% of total NHS hospital and community service costs, and the maximum simulated cost for 7000 person years was 6.8%. Simulated variation was robust to assumption about prices and referral rates for specific types of referral.Rare costly referrals seem unlikely to bankrupt total purchasing sites. The management of risk is not in itself justification for total purchasing to be based in several general practices in order to generate large populations. There are other ways of managing risk. Sites can easily explore options by simulations using local referral rates and prices.
Effectiveness of an Integrated Pest Management Intervention in Controlling Cockroaches, Mice, and Allergens in New York City Public Housing
Authors: Daniel Kass, Wendy McKelvey, Elizabeth Carlton, Marta Hernandez, Ginger Chew, Sean Nagle, Robin Garfinkel, Brian Clarke, Julius Tiven, Christian Espino, David Evans
Journal: Environmental Health Perspectives (2009)

Cockroaches and mice, which are common in urban homes, are sources of allergens capable of triggering asthma symptoms. Traditional pest control involves the use of scheduled applications of pesticides by professionals as well as pesticide use by residents. In contrast, integrated pest management (IPM) involves sanitation, building maintenance, and limited use of least toxic pesticides.We implemented and evaluated IPM compared with traditional practice for its impact on pests, allergens, pesticide use, and resident satisfaction in a large urban public housing authority.We assigned IPM or control status to 13 buildings in five housing developments, and evaluated conditions at baseline, 3 months, and 6 months in 280 apartments in Brooklyn and Manhattan, in New York City (New York). We measured cockroach and mouse populations, collected cockroach and mouse urinary protein allergens in dust, and interviewed residents. All statistical models controlled for baseline levels of pests or allergens.Compared with controls, apartments receiving IPM had significantly lower counts of cockroaches at 3 months and greater success in reducing or sustaining low counts of cockroaches at both 3 and 6 months. IPM was associated with lower cockroach allergen levels in kitchens at 3 months and in beds and kitchens at 6 months. Pesticide use was reduced in IPM relative to control apartments. Residents of IPM apartments also rated building services more positively.In contrast to previous IPM studies, which involved extensive cleaning, repeat visits, and often extensive resident education, we found that an easily replicable single IPM visit was more effective than the regular application of pesticides alone in managing pests and their consequences.
Space phobia: syndrome or agoraphobic variant?
Authors: I Marks, P Bebbington
Journal: BMJ (1976)

Four elderly women had intense fears of falling when there was no visible support at hand or on seeing space cues while driving. Two patients had cervical spondylosis. The mean age at onset of the fear was 54--thirty years later than that for agoraphobia. Fear of public places and of heights was not prominent, nor was depersonalisation or depression. These "space phobias" might be a hitherto unrecognised syndrome or an unusual variant of agoraphobia. The visuospatial reflexes involved might illuminate the pathogenesis of certain fears.
PREVALENCE AND PREDICTORS OF ANGIOGRAPHIC STENT FRACTURE AND STENT FRACTURE WITH RESTENOSIS AFTER BARE METAL AND DRUG-ELUTING STENT IMPLANTATION
Authors: Yuki Hayakawa, Kazushige Kadota, Shunsuke Kubo, Masatomo Ozaki, Nobuaki Yamauchi, Mitsuru Yoshino, Koshi Miyake, Haruki Eguchi, Noriyuki Ohashi, Naoki Saito, Suguru Otsuru, Daiji Hasegawa, Yoshikazu Shigemoto, Seiji Habara, Takeshi Tada, Hiroyuki Tanaka, Takeshi Maruo, Akitoshi Hirono, Shingo Hosogi, Yasushi Fuku, Naoki Oka, Harumi Katoh, Hiroyuki Yamamoto, Tsuyoshi Goto, Kazuaki Mitsudo
Journal: Journal of the American College of Cardiology (2011)
Commentary: pleural empyema and malignancy--another dimension.
Authors: P. H. Johnson, J. T. Macfarlane
Journal: Thorax (1996)

The case is described of a 72 year old woman who presented with a two year history of exertional stridor in whom the diagnosis of myasthenia gravis was delayed.Although an uncommon cause, my- asthenia gravis should be included in the differential diagnosis of stridor.
University cuts, medicine, and the public interest.
Authors: P Richards
Journal: BMJ (1984)

University cuts, medicine, and the public interest Britain's universities are in rough water.To some extent faculties of medicine have been sheltered, but even their public funding has fallen in real terms by 10-15'"" in three years.The immediate future offers no hope of calm-indeed, university grants seem certain to fall behind inflation.Against this background the Secretary of State for Education has asked how universities would cope if their student intake were to remain constant but their income were to fall progressively by a further 10-15',, per student over the next decade.This question, speculative but with a sting in its tail, is not about the number of students (medical or not) but about resources per student.
Salt Retention and Uraemia in Brain Injury
Authors: R. J. S. Metz, W. Cooper
Journal: BMJ (1958)

A HAEMOPHILIAC Bu several days, and it was interesting to note that venous thromboses did not occur at the sites of infusion.Pain along the course of a vein into which potassium is being infused has been reported (Semler, 1925 ; Pudenz et al., 1938; Nadler et al., 1950).The majority of instances occurred after the use of concentrated solutions of potas- o 30 U Z 25 * .20 '.
Papillary Muscles Do Not Attach Directly to the Solid Heart Wall
Authors: Leon Axel
Journal: Circulation (2004)

The papillary muscles (PMs) play an important role in normal cardiac function, helping to prevent leakage through the AV valves during systole. The nature of their attachment to the heart wall can affect the understanding of their function. This attachment is conventionally portrayed as a direct connection of their bases to the solid portion of the heart wall. X-ray multidetector CT provides a new, noninvasive way to investigate this connection in vivo.With the use of x-ray multidetector CT with interactive 3D reconstruction, the bases of the PMs are seen to attach to the trabeculae carneae lining the ventricular wall rather than directly to the solid portion of the wall, as has been conventionally believed. This is true for both the left and right ventricular PMs.This new picture of the geometry of the attachment of the PMs to the heart wall may have important implications for the understanding of their function, including the nature of the transmission of the forces between the PMs and the heart wall.
On the Anticipation of Post Partum Haemorrhage
Authors: E. Whittle
Journal: BMJ (1873)

6oi difficult to transfer the pressure to the aorta, a proceeding which I have often seen of great service; then cold may be added as an excellent assistant to pressure; in certain cases, opium is a valuable remedy.The precise position which a solution of the perchloride of iron will occupy in the future I cannot tell; it has not, in my hands, appeared to be so innocent an agent as, from what has been written about it, I had sup- posed; but, as my experience has been limited, I give no decided opinion.
Endothelial infection with KSHV genes in vivo reveals that vGPCR initiates Kaposi's sarcomagenesis and can promote the tumorigenic potential of viral latent genes
Authors: Silvia Montaner, Akrit Sodhi, Alfredo Molinolo, Thomas H Bugge, Earl T Sawai, Yunsheng He, Yi Li, Patricio E Ray, J.Silvio Gutkind
Journal: Cancer Cell (2003)
Tumoral Calcinosis Associated with Sarcoidosis and Positive Bone and Gallium Imaging
Authors: FRANCINE M. WOLPE, NANDA Y. KHEDKAR, DONALD GORDON, PHILIP WERNER, PARVEZ SHIRAZI, M H AL-SABBAN
Journal: Clinical Nuclear Medicine (1987)

A 63-year-old female with biopsy proven tumoral calcinosis presented with progressive and recurrent swelling and tenderness of the right hip, thigh, elbow, and wrist. Both gallium and bone imaging demonstrated intense, congruent uptake in these areas. This is the third case of tumoral calcinosis with sarcoidosis documented in the literature. However, these are the first published bone and gallium scans in a patient with a history of sarcoidosis and tumoral calcinosis.
Captopril-associated lymphadenopathy
Authors: S Freestone
Journal: BMJ (1982)

the investigation of all aged demented patients since the yield of "potentially reversible" causes will certainly be low and the yield of "actually reversible" causes even lower.There are patients of all ages (including aged demented patients) in whom computed tomo- graphy is a valuable procedure, but they will all have to wait a very long time for their scans if we all follow what appears to be Professor Millard's advice and seek computed tomo- graphy scans for all our aged demented patients.
Critical Reviewing of Software
Authors: M.S. BLOIS
Journal: Annals of Internal Medicine (1984)

Letters and Corrections1 July 1984Critical Reviewing of SoftwareM.S. BLOIS, M.D.M.S. BLOIS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-101-1-139_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The April issue ofAnnalshas launched a novel and laudable precedent by reviewing in its "Literature of Medicine" section several medical software products. Yet, there are potential complications here of which editors, reviewers, and readers should be aware. A computer program differs greatly from a book, essay, or scientific report. A computer program is designed to do something in a way that a book or article is not, and it can be evaluated by seeing if its intent is realized. When medical software is to be judged, it is important in the interests of fairness and...Reference1. MILLER R. INTERNIST (software review). Ann Intern Med. 1984; 100:622-3. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: M.S. BLOIS, M.D.Affiliations: University of California, San Francisco San Francisco, CA 94143 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCongress's contempt power: Three mechanisms for enforcing subpoenasComputer-assisted diagnosis of rheumatic disordersComputer-Assisted DiagnosisHerbert S. Wax man, MD, William E. Worley, MDSoftware Review of The INTERNIST™RANDOLPH A. MILLER, M.D. 1 July 1984Volume 101, Issue 1Page: 139-140KeywordsSoftware tools ePublished: 1 December 2008 Issue Published: 1 July 1984 PDF downloadLoading ...
Survival in a world of probable objects: A fundamental reason for Bayesian enlightenment
Authors: Shimon Edelman, Reza Shahbazi
Journal: Behavioral and Brain Sciences (2011)

Abstract The only viable formulation of perception, thinking, and action under uncertainty is statistical inference, and the normative way of statistical inference is Bayesian. No wonder, then, that even seemingly non-Bayesian computational frameworks in cognitive science ultimately draw their justification from Bayesian considerations, as enlightened theorists know fully well.
How Diphtheria is spread by Corpses, through Carelessness in one Locality, and promptly restricted by a faithful Health Officer in another Locality.
Authors: Henry B. Baker
Journal: JAMA (1890)

<h3>To the Editor:</h3> —April 25, 1890, a copy of the<i>Atlanta Tribune</i>, Atlanta, Montmorency County, Mich., April 17, 1890, reached the office of the State Board of Health, in which appeared the following item: <h3>"Reported to be over Twenty Cases of Diphtheria in and around Vienna.</h3> —Vienna being an unincorporated village in Albert township, Montmorency county, a letter asking report and urging a prompt restriction of the alleged diphtheria was immediately sent to J. T. Dimmick, health officer of Albert township, May 8. The following reply was received: <h3>"Sir:</h3> —This is to inform you that the item in the<i>Atlanta Tribune</i>was false. There has not been a case of diphtheria at or near Vienna. Dr. Warren, of Gaylord, said it belonged to la grippe and was not contagious. Yours truly, J. T.Dimmick, Health Officer. "P. S. Sulphur was burned as a disinfectant." Just why disinfection was attempted if
The Question of the Questionable Questionnaire
Authors: John R. Whittier
Journal: JAMA (1970)

<h3>To the Editor.—</h3> This doggerel by Mrs. Edward Craster is offered in the hope that the publication of this letter will resolve a mounting personal conflict: A centipede was happy, quite Until the toad, in fun Said, "Pray which leg comes after which?" This raised her doubts to such a pitch She fell distracted in a ditch, Uncertain how to run. By now I am receiving questionnaires of such length, with such frequency, and from such diverse sources that if I were to answer them I would do nothing else. Answering cannot be delegated, or they would not have been sent to me. This is despite the fact that many of them are deserving of reply, posing the additional problem which to answer, or whether to answer none. Furthermore, most questionnaires are either unfamiliar with the field they are inquiring about or so nonspecific as to be meaningless if answered
Diphtheria Antitoxin in the Treatment of Bronchial Asthma.
Authors: F. E. Kitzmiller
Journal: JAMA (1907)

Piqua, Ohio, Feb. 26, 1907. <h3>To the Editor:</h3> —After an experience of more than twenty-five years in the practice of medicine, the most interesting case I ever saw was one of bronchial asthma. The reason this case was of such interest is that I was the patient. It may be taken for granted that I patiently and persistently tried every means for the relief of this condition, but still suffered nightly with from one to three attacks, and for six years never escaped a night. It is true that I received temporary relief from various remedies, but there was always a return of the attack within three or four hours after retiring. During these attacks I tried and wore out one remedy after another, and I am sure I overlooked nothing that has ever been used by the medical profession for this condition. I used inhalations, from stramonium leaves to
Abstract 4041: Lipofection of the designed plasmid expressing microRNA-7 has antitumor effect in gefitinib-resistant lung adenocarcinoma <i>in vivo</i>
Authors: Kammei Rai, Nagio Takigawa, Sachio Ito, Hiromi Kashihara, Eiki Ichihara, Katsuyuki Kiura, Tatsuji Yasuda, Kenji Shimizu, Mitsune Tanimoto
Journal: Cancer Research (2010)

Abstract Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) is strikingly effective in tumors harboring activating EGFR mutations since the tumor cells depend on “oncogene addiction” to EGFR signaling that is inhibited effectively by a change in the affinity of ATP and EGFR-TKI to ATP binding site of mutated EGFR. Unfortunately, approximately 50% of patients who responded to EGFR-TKI acquired the resistance to EGFR-TKI due to additional mutation T790M in EGFR. Since T790M mutation restores the affinity of ATP to the ATP binding site of mutated EGFR, the oncogene addiction by EGFR pathway is presumed to sustain in the gefitinib-resistant cells harboring T790M mutation. MicroRNA-7 (miR-7) is predicted to suppress EGFR expression by targeting three sites in the 3′-untranslated region (UTR) of EGFR mRNA in silico. It was proved to be a potential tumor suppressor in EGFR-TKI-resistant lung adenocarcinoma cells by targeting the 3′-UTR of EGFR mRNA (#1396: Annual AACR meeting, 2009). The object of this experiment is to elucidate whether the miR-7 is effective or not in vivo. We established gefitinib-resistant lung adenocarcinoma cell line (RPC-9) carrying a secondary mutation T790M (Cancer Res 67: 7807-14, 2007) from gefitinib-sensitive EGFR mutated (delE746-A750 in exon 19) PC-9 cell line. RPC-9 cells (2 × 106) were injected s.c. into the backs of the female athymic mice at 7 week of age. At 1 week after injection, the mice were randomly assigned into one of three groups (five mice per group) that received either 3 μg/body of miR-7 expressing plasmid, control plasmid or mock using cationic liposome by direct injection. Marked tumor regression was observed within 2 weeks, and 60% of xenograft tumors disappeared. The immunostaining of residual tumor showed the suppression of EGFR expression on the tumor cells. To our knowledge, this is the first report to show the dramatic effect of miR-7 against EGFR-TKI resistant lung cancer model in vivo.Tumor size after treatment with miR-7 Day 1Day 5Day 11Day 18miR-710094.9445.7914.62*Control100144.0103.3242.6*tumor size(%), *p=0.00253, tumor diminished macroscopically in miR-7 group(3/5) Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4041.
Increase in skin mast cells following chronic house dust mite exposure
Authors: E.B. MITCHELL, J. CROW, G. WILLIAMS, T.A.E. PLATTS-MILLS
Journal: British Journal of Dermatology (1986)

Application of inhalant allergens in high concentration to the mildly abraded skin of sensitive patients with atopic dermatitis gave rise to eczematous skin responses at 48 h. These lesions, infiltrated by basophils, eosinophils and mononuclear cells, are examples of cutaneous basophil hypersensitivity. Repeated application of allergen induced an increase in skin mast cells by 6 days, the mast cell hyperplasia replacing the earlier basophil infiltration. No electron microscopic evidence of mast cell heterogeneity among the recruited cells was found.
Differences in mortality from acute myocardial infarction between coronary care unit and medical ward: treatment or bias?
Authors: R Reznik, I Ring, P Fletcher, V Siskind
Journal: BMJ (1987)

To analyse the effectiveness of coronary care units in reducing mortality from myocardial infarction 18 hospitals ranging from large urban teaching hospitals to small country hospitals were stratified into four levels of care. Previous analysis had failed to show significant differences in the overall mortality in hospital among levels. There were significant differences in mortality, however, between those patients allocated to be cared for in the coronary care unit and those in the medical wards in the more advanced hospitals. The differences were largest in the hospitals with the most elaborate facilities (level 1) and non-existent in those with the least (level 4). Several analytical approaches to these observed differences indicated that they were: (a) reduced by adjustment for age and severity of infarction; (b) paralleled by differences in coexisting disease recorded on death certificates; (c) no longer significant at level 1 after allowing for differences in coexisting disease; and (d) not significant at any level after exclusion of patients first diagnosed at necropsy. These findings suggest that the observed differences in mortality between coronary care units and medical wards are largely due to bias in selection and diagnosis.
Propranolol, oxprenolol, and sclerosing peritonitis.
Authors: J H Marigold, R E Pounder, J Pemberton, R P Thompson
Journal: BMJ (1982)

Patients responding,with time on tamoxifen to date.(Figures in parentheses are numnbers of patients zizhsubsequently relapsed) Response at: Type of response (lasting -6 months) No 3 years *2-3 years 1-2 years ',-1 vear year Complete (impalpable) 18 5 4 (2) 5 4 -Partial (5010 reduction) 14 1 2 3 (1) 4 4 Static but softened 17 3