tbuckley/cabot-search huggingface dataset:
Correlation between centromere protein-F autoantibodies and cancer analyzed by enzyme-linked immunosorbent assay
Authors: Simon Welner, Nicole Hartwig Trier, Morten Frisch, Henning Locht, Paul Robert Hansen, Gunnar Houen
Journal: Molecular Cancer (2013)

Centromere protein-F (CENP-F) is a large nuclear protein of 367 kDa, which is involved in multiple mitosis-related events such as proper assembly of the kinetochores, stabilization of heterochromatin, chromosome alignment and mitotic checkpoint signaling. Several studies have shown a correlation between CENP-F and cancer, e.g. the expression of CENP-F has been described to be upregulated in cancer cells. Furthermore, several studies have described a significant correlation between the expression of autoantibodies to CENP-F and cancer.Autoantibodies to CENP-F were detected in a small number of samples during routine indirect immunofluorescence (IIF) analysis for anti-nuclear antibodies (ANA) using HEp-2 cells as substrate. Using overlapping synthetic peptides covering a predicted structural maintenance of chromosomes (SMC) domain, we developed an enzyme-linked immunosorbent assay (ELISA) for detection of CENP-F antibodies.Analyzing the reactivity of the sera positive in IIF for CENP-F antibodies to overlapping CENP-F peptides, we showed that autoantibodies to several peptides correlate with the presence of antibodies to CENP-F and a diagnosis of cancer, as increased CENP-F antibody expression specific for malignant cancer patients to five peptides was found (A9, A12, A14, A16, A27). These antibodies to CENP-F in clinical samples submitted for ANA analysis were found to have a positive predictive value for cancer of 50%. Furthermore, the expression of cancer-correlated CENP-F antibodies seemed to increase as a function of time from diagnosis.These results conform to previous findings that approximately 50% of those patients clinically tested for ANA analyses who express CENP-F antibodies are diagnosed with cancer, confirming that these antibodies may function as circulating tumor markers. Thus, a peptide-based CENP-F ELISA focused on the SMC domain may aid in identifying individuals with a potential cancer.
Neuroleptic Malignant Syndrome-Reply
Authors: RODOLOJUB Dimitrijevic
Journal: JAMA (1986)

<h3>In Reply.—</h3> Dr Pettus raises interesting issues in his letter. Sympathetic hyperactivity occurs in NMS and manifestations include high blood pressure and tachycardia. The consequent increase in cardiac work in an older patient causes concern about the risk of myocardial infarction and this concern led us to use propranolol for symptomatic management. In a younger person in otherwise good health, we might have not chosen to use propranolol. There is no reason to believe propranolol by itself would have controlled the severe muscle rigidity, and it cannot be the primary medication in controlling NMS. It can, however, be a useful adjunct. The patient was given 10 mg of diazepam intramuscularly, with insignificant results the day before treatment with pancuronium began. Diazepam may be useful in reducing muscle rigidity in mild cases of NMS, but did not control the severe rigidity in our patient. Muscle paralysis through the use of pancuronium
Myasthenic syndrome during treatment with practolol.
Authors: L Wislicki
Journal: BMJ (1976)

Myasthenic syndrome during treatment with practolol SIR,-The myasthenic syndrome during treat- ment with large doses of practolol described by Drs R 0 Hughes and F J Zacharias (21 February, p 460) appears to be a clinical manifestation of the effect of 3-adrenoceptor blocking agents on the neuromuscular junction observed in animals.Like other members of this group of drugs' 2 practolol has a curare- like action, as shown in sciatic nerve- gastrocnemius preparations of the cat:' and frog and in the frog sciatic nerve-sartorius preparation and rectus abdominis muscle.2 4 The dosage required to depress neuromuscular transmission was larger for practolol than for propranolol.Though the patient's electromyogram, presumably taken in the resting state, was normai, it would be of great interest to know whether in the myasthenic state repetitive nerve stimulation evoked a gradually declining response of the muscle and whether even in the absence of the myasthenic syndrome the patient was particularly prone to fatigue.As in experimental animals the neuromuscular effects of '3-adrenoceptor blockers are readily reversible the risk of a relapse of the myas- thenic syndrome seems to be remote.How- ever, the patient may be hypersensitive to D-tubocurarine and related agents and also to drugs with a local anaesthetic action, like quinidine.
Prevalence and Prognostic Significance of T-Wave Inversions in Right Precordial Leads of a 12-Lead Electrocardiogram in the Middle-Aged Subjects
Authors: Aapo L. Aro, Olli Anttonen, Jani T. Tikkanen, M. Juhani Junttila, Tuomas Kerola, Harri A. Rissanen, Antti Reunanen, Heikki V. Huikuri
Journal: Circulation (2012)

T-wave inversion in right precordial leads V(1) to V(3) is a relatively common finding in a 12-lead ECG of children and adolescents and is infrequently found also in healthy adults. However, this ECG pattern can also be the first presentation of arrhythmogenic right ventricular cardiomyopathy. The prevalence and prognostic significance of T-wave inversions in the middle-aged general population are not well known.We evaluated 12-lead ECGs of 10 899 Finnish middle-aged subjects (52% men, mean age 44 ± 8.5 years) recorded between 1966 and 1972 for the presence of inverted T waves and followed the subjects for 30 ± 11 years. Primary end points were all-cause mortality, cardiac mortality, and arrhythmic death. T-wave inversions in right precordial leads V(1) to V(3) were present in 54 (0.5%) of the subjects. In addition, 76 (0.7%) of the subjects had inverted T waves present only in leads other than V(1) to V(3). Right precordial T-wave inversions did not predict increased mortality (not significant for all end points). However, inverted T waves in leads other than V(1) to V(3) were associated with an increased risk of cardiac and arrhythmic death (P<0.001 for both).T-wave inversions in right precordial leads are relatively rare in the general population, and are not associated with adverse outcome. Increased mortality risk associated with inverted T waves in other leads may reflect the presence of an underlying structural heart disease.
Two-year follow-up survey of patients with allergic contact dermatitis from an occupational cohort: is the prognosis dependent on the omnipresence of the allergen?
Authors: K.K.B. Clemmensen, T.K. Carøe, S.F. Thomsen, N.E. Ebbehøj, T. Agner
Journal: British Journal of Dermatology (2013)

Skin diseases are the most frequently recognized occupational diseases in Denmark. The prognosis for occupational contact dermatitis is often poor.To investigate the prognosis, assessed by eczema, job status and skin-related quality of life, among patients allergic to rubber chemicals and latex (ubiquitous allergens) and epoxy (nonubiquitous allergen), 2 years after recognition of occupational allergic contact dermatitis.From a cohort of all patients recognized as having occupational dermatitis by the Danish National Board of Industrial Injuries in 2010, 199 patients with relevant rubber allergy (contact allergy to rubber chemicals or contact urticaria from latex) or epoxy allergy were identified. Follow-up consisted of a questionnaire covering current severity of eczema, employment, exposure and quality of life.The response rate was 75%. Clearance of eczema was reported by 11% of patients and 67% reported improvement. Overall 22% of patients with allergy to a nonubiquitous allergen had total clearance of eczema compared with 10% of cases allergic to ubiquitous allergens and 0% of those with contact urticaria (P = 0·116). Improvement was significantly more frequent in those who had changed jobs compared with those who had not (P = 0·01).At follow-up, patients with contact urticaria had significantly poorer prognosis than those with contact allergy, and there was a trend towards a poorer prognosis for those with contact allergy to rubber chemicals than those with allergy to epoxy. A significant positive association between job change and improvement was found.
Remarks ON ECTOPIC GESTATION AND THE CONDITIONS FAVOURABLE FOR ITS ADVANCE TO THE FULL TERM
Authors: J. W. Cousins
Journal: BMJ (1903)

THE fertilized ovum may be arrested within the ovary or in any part of the Fallopian tube in its passage to the uterus, and when this occurs it seldom escapes destruction amid the many dangers which threaten its vitality.During the first few weeks the ovum may be destroyed and absorbed without any symptoms sufficiently definite to indicate the real nature of the accident.Tubal arrest and tubal abortion may both take place before any marked symptoms of pregnancy have developed, and the transient disturbance attending them may be regarded only as a recurrence of menstruation.Even early rupture of the tube may take place without any definite indications.The shock attending the accident may be slight, and the evidence of haemorrhage obtainable by palpation and bimanual examination very unreliable.Difficulty in Diagnosis ofEarly Tubal Pregnancy.In the aibsence of abdominal tenderness and swelling and of well-marked signs and symptoms of pregnancy, it is certainly not surprising that early tubal gestation should sometimes be destroyed, and the patient speedily recover without any
Noninvasive Risk Stratification of Lung Adenocarcinoma using Quantitative Computed Tomography
Authors: Sushravya Raghunath, Fabien Maldonado, Srinivasan Rajagopalan, Ronald A. Karwoski, Zackary S. DePew, Brian J. Bartholmai, Tobias Peikert, Richard A. Robb
Journal: Journal of Thoracic Oncology (2014)
Remarks on Chronic Gastric Ulcer and Pyloric Stenosis and their Treatment by Gastro-Enterostomy: Read before the Croydon Division (South-Eastern Branch) of the British Medical Association
Authors: H. F. Waterhouse
Journal: BMJ (1904)

GASTRIC ULCER AND, PYLORIC STENOSIS.[i = I] which were subsequently proved to be due to pneumococcus infection, that I do not hesitate to add the case to the others of the series.The patient was a strong, healthy woman.She was seen almost immediately after the development of her first symptoms, and vigorous treatment was commenced at once.No development of further symptoms occurred, but there was definite illness and prostration, which lasted until the seventh day.In conclusion, it is interesting to note the length of the incubation period in each case.Of the source of infection in Case i we know nothing.She could not have infected Case ii, as far as we know, before the night of May 8th.He recognized his first symptoms on rising on May X x th-roughly, say, fifty- .eighthours.Case II and Case iii were in contact for a short time between IO a.m. and I p.m. on May iith.The first symptoms were exhibited during breakfast on May 14th- Toughly, sixty-nine hours.The earliest period of infection of Case Iv appears to have been about io a.m. on May 12th, and her first symptoms appeared at 7 a.m. on the 14th-a period of only forty-five hours.This period is, however, open to question, as this patient had already run a distinct risk of infection by washing the infected handkerchiefs used by ¢ase I.Case v appears to be much more definite as regards incuba- tion.I saw the patient constantly whilst visiting Cases i -and II; she was in vigorous, good healtb.One one occasion, and one only, was she in the sick-room for anything more than a minute or two; we may, I think, reasonably take it *that she became infected between I and 2 a.m. on May 17th.She began to feel ill about g a.m. on May igth-a period of fifty-five hours.
Histologic changes and arrhythmogenicity after discharge through transseptal catheter electrode.
Authors: J C Davis, W Finkebeiner, M A Ruder, L DiCarlo, T Matsubara, W Chu, S A Winston, S Bharati, M M Scheinman, M Lev
Journal: Circulation (1986)

Ventricular tachycardia commonly arises within the intraventricular septum and successful catheter ablation of septal tachycardia might be enhanced by transseptal electrode placement. We have evaluated the safety of a transseptal ablation procedure. Arrhythmogenicity and histology were examined after high-energy capacitor discharges were delivered to an intracavitary cathode-anode pair placed on opposite sides of the interventricular septum in pentobarbital-anesthetized dogs. After two discharges of 200 or 100 J proved lethal, paired discharges of 30 or 50 J (10 dogs) or a single discharge of 100 J (four dogs) was used to induce 28 lesions. Acute rhythm changes and risk of induction of ventricular tachycardia by programmed stimulation were measures of arrhythmogenicity. Gross and histologic examination of the hearts after 20 min to 28 days allowed characterization of the evolution of lesions. The conduction system in nearby and remote locations was extensively examined in four dogs. Refractory ventricular fibrillation developed with paired shocks at 200 or 100 J. At lower energy levels, acute ventricular fibrillation occurred with 12 of 20 shocks (60%), but defibrillation was consistently achieved. After ablation, no dog had ventricular tachycardia or fibrillation induced with programmed stimulation. Matching anodal and cathodal lesions spanned the septum without perforation in 10 of 16 dogs, and the lesions were of similar histology. Each contained central areas of hemorrhage surrounded by a region of coagulation necrosis merging with normal myocytes peripherally. There was necrosis and edema without inflammation at 20 min, acute inflammatory cell infiltration at 1 to 2 days, and myocyte replacement by granulation tissue after 6 days.(ABSTRACT TRUNCATED AT 250 WORDS)
Our 3-year Experience with Patch Testing for Eosinophilic Esophagitis
Authors: C.S. Bauer, A.R. Lamba, H.P. Zimmerman, R.G. Hoffmann, M. Dasgupta, R.J. Noel, M.B. Levy, M. Vasudev
Journal: Journal of Allergy and Clinical Immunology (2012)
Abnormal Metabolism of γ-Trace Alkaline Microprotein
Authors: Anders Grubb, Olafur Jensson, Gunnar Gudmundsson, Alfred Arnason, Helge Löfberg, Johan Malm
Journal: New England Journal of Medicine (1984)

ALTHOUGH the total incidence of cerebral hemorrhage is high, comparatively few reports concerning the familial occurrence of this disease have been published.1 , 2 In 1935 Arnason described 10 families with a high incidence of cerebral hemorrhage and concluded that a hereditary form of the disease was present in these families.3 Further clinicopathological investigations of the disease revealed an autosomal dominant inheritance and a connection between the disease and a special form of amyloidosis confined to the cerebral vasculature.4 This type of cerebral hemorrhage is therefore generally referred to as hereditary cerebral hemorrhage with amyloidosis. Recently, the fibrillar components of the amyloid . . .
Myocyte Death, Growth, and Regeneration in Cardiac Hypertrophy and Failure
Authors: Bernardo Nadal-Ginard, Jan Kajstura, Annarosa Leri, Piero Anversa
Journal: Circulation Research (2003)

The accepted paradigm considers the adult mammalian heart as a postmitotic organ, which possesses a relatively constant number of myocytes from shortly after birth to adulthood and senescence. This notion is questioned by the demonstration that although most adult myocytes are terminally differentiated, there is a small and continuously renewed subpopulation of cycling myocytes produced by the differentiation of cardiac stem-like cells. Myocyte death and myocyte regeneration are introduced as major determinants of cardiac homeostasis and alterations of ventricular anatomy and function in physiological and pathological states. The possibility of reconstituting dead myocardium by stem-like cells is advanced and proposed as a major area of future research.
Outcomes of Paraesophageal Hernia Repair
Authors: Dmitry Oleynikov
Journal: JAMA Surgery (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Local and global gene therapy in the central nervous system
Authors: Leslie L. Muldoon, Edward A. Neuwelt
Journal: Behavioral and Brain Sciences (1995)

Abstract For focal neurodegenerative diseases or brain tumors, localized delivery of protein or genetic vectors may be sufficient to alleviate symptoms, halt disease progression, or even cure the disease. One may circumvent the limitation imposed by the blood-brain barrier by transplantation of genetically altered cell grafts or focal inoculation of virus or protein. However, permanent gene replacement therapy for diseases affecting the entire brain will require global delivery of genetic vectors. The neurotoxicity of currently available viral vectors and the transient nature of transgene expression in vivo must be overcome before their use in human gene therapy becomes clinically applicable.
Persistent atrial fibrillation: rate control or rhythm control
Authors: C. J Boos
Journal: BMJ (2003)

Rate control is not inferior to rhythm control 

Atrial fibrillation is the commonest sustained tachyarrhythmia encountered in clinical practice.1 With an ageing population and improved survival of patients with cardiac disease its prevalence continues to rise.2 It is associated with a doubling of overall morbidity and mortality from cardiovascular disease3 and is the most common cause of embolic stroke.4 Restoring sinus rhythm holds the theoretical advantage of reducing the risk of thromboembolism and need for anticoagulation and improved haemodynamics and quality of life. However, most current anti-arrhythmic drugs have limited efficacy and several side effects. With the use of anti-arrhythmics and serial electrical cardioversion for early relapse up to 53% of patients are in sinus rhythm at one year,5 but only 25% remain so at five years.6 Considerable controversy therefore exists as to whether rhythm or rate control is the more appropriate management for most patients with persistent atrial fibrillation. Five recent trials have looked specifically at this issue.

The PIAF study was the first randomised published …
Use of Morcellation to Remove Fibroids Scrutinized at FDA Hearings
Authors: Tracy Hampton
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Study of infection with HIV and related risk factors in young offenders' institution.
Authors: A G Bird, S M Gore, S M Burns, J G Duggie
Journal: BMJ (1993)

OBJECTIVES--To estimate the prevalence of infection with HIV in young offenders in Scotland and to obtain information about related risk factors and previous tests for HIV. DESIGN--Voluntary anonymous study with subjects giving saliva samples for testing for HIV and completing questionnaires about risk factors. SETTING--Polmont Young Offenders9 Institution near Falkirk, Scotland. SUBJECTS--421 of 424 available male prisoners in Polmont. The questionnaires of 17 of the prisoners were excluded because of inaccuracies. MAIN OUTCOME MEASURES--Prevalence of infection with HIV and related risk behaviour. RESULTS--68 (17%) of prisoners admitted misuse of intravenous drugs, of whom 17 (25%) admitted having injected drugs while in prison. Three subjects admitted having anal intercourse while in prison. Prevalence of misuse of intravenous drugs varied geographically: 28% (33/120) of prisoners from Glasgow compared with 9% (7/81) of those from Edinburgh and Fife. A high level of heterosexual activity was reported, with 36% (142/397) of prisoners claiming to have had six or more female sexual partners in the year before they were imprisoned. Altogether 8% (32/389) of prisoners had previously taken a personal test for HIV: 50% (9/18) of those who had started misusing intravenous drugs before 1989, 18% (9/49) of those who started misuse later, and only 4% (14/322) of those who had not misused intravenous drugs. No saliva sample tested positive for antibodies to HIV, but 96 prisoners requested a confidential personal test for HIV as a result of heightened awareness generated by the study. CONCLUSIONS--Voluntary, anonymous HIV surveys can achieve excellent compliance in prisons, and the interest generated by the study suggests that prisons may be suitable sites for providing education and drug rehabilitation for a young male population at high risk of future infection with HIV.
100 000 children die needlessly from cancer every year
Authors: Vittal Katikireddi
Journal: BMJ (2004)

Children throughout the developing world lack access to even the most basic cancer treatment and pain relief, leading to the needless deaths of 100 000 children every year, say two leading cancer organisations.

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Cancer groups are asking the UN secretary general, Kofi Annan, for support

Credit: EPA/PA

The organisations say that cooperation is needed between the World Health Organization, the World Trade Organisation, and the pharmaceutical industry so that the price of anticancer drugs can be reduced.

Cancer Research UK, which funds the …

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