tbuckley/cabot-search huggingface dataset:
ACQUIRED (DIGITAL) FIBROKERATOMA
Authors: P. J. HARE, P. A. J. SMITH
Journal: British Journal of Dermatology (1969)

Journal Article ACQUIRED (DIGITAL) FIBROKERATOMA Get access P. J. HARE, P. J. HARE Department of Dermatology, University of Edinburgh, and the Queen Victoria Hospital, East Grinstead Search for other works by this author on: Oxford Academic Google Scholar P. A. J. SMITH P. A. J. SMITH Department of Dermatology, University of Edinburgh, and the Queen Victoria Hospital, East Grinstead Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 81, Issue 9, 1 September 1969, Pages 667–670, https://doi.org/10.1111/j.1365-2133.1969.tb16205.x Published: 01 September 1969 Article history Accepted: 30 January 1969 Published: 01 September 1969
Effect of Anatomical Distribution of Mast Cells on Their Defense Function against Bacterial Infections
Authors: Tomoko Jippo, Eiichi Morii, Akihiko Ito, Yukihiko Kitamura
Journal: The Journal of Experimental Medicine (2003)

Mast cells were depleted in the peritoneal cavity of WBB6F1-tg/tg mice that did not express a transcription factor, MITF. When acute bacterial peritonitis was induced in WBB6F1-+/+, WBB6F1-W/Wv, and WBB6F1-tg/tg mice, the proportion of surviving WBB6F1-+/+ mice was significantly higher than that of surviving WBB6F1-W/Wv or WBB6F1-tg/tg mice. The poor survival of WBB6F1-W/Wv and WBB6F1-tg/tg mice was attributed to the deficient influx of neutrophils into the peritoneal cavity. The injection of cultured mast cells (CMCs) derived from WBB6F1-+/+ mice normalized the neutrophil influx and reduced survival rate in WBB6F1-W/Wv mice, but not in WBB6F1-tg/tg mice. This was not attributable to a defect of neutrophils because injection of TNF-α increased the neutrophil influx and survival rate in both WBB6F1-W/Wv and WBB6F1-tg/tg mice. Although WBB6F1-+/+ CMCs injection normalized the number of mast cells in both the peritoneal cavity and mesentery of WBB6F1-W/Wv mice, it normalized the number of mast cells only in the peritoneal cavity of WBB6F1-tg/tg mice. Mast cells within the mesentery or mast cells in the vicinity of blood vessels appeared to play an important role against the acute bacterial peritonitis. WBB6F1-tg/tg mice may be useful for studying the effect of anatomical distribution of mast cells on their antiseptic function.
Biological characteristics of young swimmers, tennis players and non-competitors.
Authors: J. Bloomfield, B. A. Blanksby, D. F. Beard, T. R. Ackland, B. C. Elliott
Journal: British Journal of Sports Medicine (1984)

One hundred and twelve finalists in the State Swimming Championships aged between seven and twelve years and 65 ranked tennis players of similar age were selected on the basis of their sporting performances. A third group comprised children of similar socio-economic status who only took part in casual sport. The tests which were used in the study were those considered to be important for successful athletic performance. A multifactorial analysis of variance and post-hoc t-tests were applied to the data to determine if any statistical differences were apparent between the three groups. The results demonstrated that no size, body shape, flexibility, strength or lung function differences were evident between the competitors and non-competitors, but that the swimmers and tennis players were superior to the non-competitors in cardiovascular endurance.
Randomised comparison of the effectiveness and costs of community and hospital based mental health services for children with behavioural
Authors: R. Harrington
Journal: BMJ (2000)

<h3>Abstract</h3> <b>Objective:</b> To test the hypothesis that a community based intervention by secondary child and adolescent mental health services would be significantly more effective and less costly than a hospital based intervention. <b>Design:</b> Open study with two randomised parallel groups. <b>Setting:</b> Two health districts in the north of England. <b>Participants:</b> Parents of 3 to 10 year old children with behavioural disorder who had been referred to child and adolescent mental health services. <b>Intervention:</b> Parental education groups. <b>Main outcome measures:</b> Parents9 and teachers9 reports of the child9s behaviour, parental depression, parental criticism of the child, impact of the child9s behaviour on the family. <b>Results:</b> 141 subjects were randomised to community (n=72) or hospital (n=69) treatment. Primary outcome data were obtained on 115 (82%) cases a year later. Intention to treat analyses showed no significant differences between the community and hospital based groups on any of the outcome measures, or on costs. Parental depression was common and predicted the child9s outcome. <b>Conclusions:</b> Location of child mental health services may be less important than the range of services that they provide, which should include effective treatment for parents9 mental health problems.
Effects of Nylidrin, Isoproterenol and Phenoxybenzamine on Dogs Subjected to Hemorrhagic Shock
Authors: GEORGE J. GREGA, WILLIAM J. KINNARD, JOSEPH P. BUCKLEY
Journal: Circulation Research (1967)

The effects of beta-adrenergic receptor stimulants (nylidrin and isoproterenol) on the hemorrhagic shock state of anesthetized dogs were measured and compared to those of phenoxybenzamine to determine the therapeutic effectiveness of the combined cardiac stimulatory and peripheral vasodilatory actions of the former drugs. Anesthetized dogs were subjected to 3 hours of hypovolemia followed by the return of the shed blood. Nylidrin, isoproterenol (continuous infusion), and phenoxybenzamine were administered 1 hour after bleeding the animals and heart rate, arterial blood pressure, venous hematocrit, coronary blood flow, cardiac output, ventricular contractility, and survival rates were measured. Nylidrin and isoproterenol afforded significant protection against shock deaths, whereas phenoxybenzamine did not increase survival over control values. Mild to moderate intestinal hemorrhage and distention were noted in the isoproterenol- and phenoxybenzamine-treated animals, but not in the nylidrin-treated animals. Phenoxybenzamine gradually decreased the arterial blood pressure and additional quantities of blood had to be infused to maintain cardiac output and blood pressure. Ventricular contractile force progressively decreased in the phenoxybenzamine-treated animals, whereas isoproterenol and nylidrin enhanced the force of ventricular contractions. In the presence of existing hypotension, isoproterenol and nylidrin maintained cardiac output. These agents deserve further consideration as potentially useful therapeutic agents in the management of shock states.
Cerebrospinal Fluid Markers of Neurodegeneration and Rates of Brain Atrophy in Early Alzheimer Disease
Authors: Rawan Tarawneh, Denise Head, Samantha Allison, Virginia Buckles, Anne M. Fagan, Jack H. Ladenson, John C. Morris, David M. Holtzman
Journal: JAMA Neurology (2015)

IMPORTANCEMeasures of neuronal loss are likely good surrogates for clinical and radiological disease progression in Alzheimer disease (AD).Cerebrospinal fluid (CSF) markers of neuronal injury or neurodegeneration may offer usefulness in predicting disease progression and guiding outcome assessments and prognostic decisions in clinical trials of disease-modifying therapies.Visinin-like protein 1 (VILIP-1) has demonstrated potential usefulness as a marker of neuronal injury in AD.OBJECTIVE To investigate the usefulness of CSF VILIP-1, tau, p-tau181, and Aβ42 levels in predicting rates of whole-brain and regional atrophy in early AD and cognitively normal control subjects over time. DESIGN, SETTING, AND PARTICIPANTSLongitudinal observational study of brain atrophy in participants with early AD and cognitively normal controls.Study participants had baseline CSF biomarker measurements and longitudinal magnetic resonance imaging assessments for a mean follow-up period of 2 to 3 years.Mixed linear models assessed the ability of standardized baseline CSF biomarker measures to predict rates of whole-brain and regional atrophy over the follow-up period.The setting was The Charles F. and Joanne Knight Alzheimer's Disease Research Center, Washington University School of Medicine in St Louis.Participants (mean age, 72.6 years) were individuals with a clinical diagnosis of very mild AD (n = 23) and cognitively normal controls (n = 64) who were enrolled in longitudinal studies of healthy aging and dementia.The study dates were 2000 to 2010. MAIN OUTCOMES AND MEASURESCorrelations between baseline CSF biomarker measures and rates of whole-brain or regional atrophy in the AD and control cohorts over the follow-up period.RESULTS Baseline CSF VILIP-1, tau, and p-tau181 levels (but not Aβ42 levels) predicted rates of whole-brain and regional atrophy in AD over the follow-up period.Baseline CSF VILIP-1 levels predicted whole-brain (P = .006),hippocampal (P = .01),and entorhinal (P = .001)atrophy rates at least as well as tau and p-tau181 in early AD.Cognitively normal controls whose CSF VILIP-1, tau, or p-tau181 levels were in the upper tercile had higher rates of whole-brain (P = .02,P = .003,and P = .02,respectively), hippocampal (P = .001,P = .01,and P = .02,respectively), and entorhinal (P = .007,P = .01,and P = .01,respectively) atrophy compared with those whose levels were in the lower 2 terciles.CONCLUSIONS AND RELEVANCE Cerebrospinal fluid VILIP-1 levels predict rates of whole-brain and regional atrophy similarly to tau and p-tau181 and may provide a useful CSF biomarker surrogate for neurodegeneration in early symptomatic and preclinical AD.
Cardiac performance in rats with renal hypertension.
Authors: D B Averill, C M Ferrario, R C Tarazi, S Sen, R Bajbus
Journal: Circulation Research (1976)

To evaluate cardiac performance in renal hypertension more precisely we determined cardiac function curves for 12 normotensive rats and 11 other rats with two-kidney Goldblatt hypertension. The hypertensive group (BP = 134 +/- 8 mm Hg) showed significant cardiac hypertrophy (44 +/- 1% increased ratio of heart weight to body weight, P less than 0.01) and markedly increased left ventricular stroke work with a moderate but not significant increase in left ventricular end-diastolic pressure (LVEDP) (5.9 +/- 0.8 vs. 4.7 +/- 0.4 mm Hg). We evaluated cardiac function by recording left ventricular end-diastolic pressure, stroke volume (SV), and cardiac output (CO) (by electromagnetic flowmeter) during rapid alteration in venous return. Analysis of variations of stroke volume vs. left ventricular end-diastolic pressure showed that renal hypertension is accompanied by a significant decrease in ventricular performance [SV = 0.0190 + 0.0509 LVEDP - 0.0025 (LVEDP)2 + 0.0001 (LVEDP)3] compared to the normotensive group [SV = 0.0430 + 0.0644 LVEDP - 0.0040 (LVEDP)2 + 0.001 (LVEDP)3]. The alterations in stroke volume and cardiac output were associated with a lack of significant changes in the work performed at matched end-diastolic pressures. The data indicate that chronic renal hypertension is accompanied by a depression of cardiac reserve which is not revealed by measurements of cardiac output and left ventricular end-diastolic pressure at rest. This impairment in cardiac function might be related to either diminished cardiac contractility or reduced left ventricular compliance; the latter possibility is in accord with our finding of a 2-fold increase in the hydroxyproline content (P less than 0.001) and a significant decrease in the DNA concentration of ventricular tissue.
Oxidative stress in families of type 1 diabetic patients.
Authors: E Matteucci, O Giampietro
Journal: Diabetes Care (2000)

The link between hyperglycemia and the complications of diabetes is unknown. It is still discussed whether oxidative stress precedes or merely reflects diabetic complications. To search for a familial predisposition to oxidative stress, we investigated indexes of glucose and lipid metabolism, markers of plasma and cell lipid oxidation, a marker of oxidant-induced protein damage, and the effects of oxygen radicals on erythrocytes (or red blood cells [RBCs]) of patients with type 1 diabetes and their relatives.We recruited 30 type 1 diabetic subjects (10 without diabetic complications, 10 with retinopathy, and 10 with nephropathy), 36 nondiabetic siblings, 37 nondiabetic parents of type 1 diabetic subjects, and 3 control groups of healthy subjects without a family history of diabetes. Levels of blood creatinine, glucose, HbA(1c), cholesterol, triglycerides, lipoprotein(a) (Lp[a]), fibrinogen, malondialdehyde (MDA), and advanced oxidation protein products were determined. The RBC response to oxidative stress (3-h incubation at 37 degrees C with or without a radical generating system) was evaluated by measuring RBC glutathione (GSH), RBC-MDA, and hemolysis.Diabetic patients had higher levels of blood glucose (P < 0.001), HbA(1c) (P < 0.001), Lp(a) (P < 0.01), and fibrinogen (P < 0.05) than control subjects. Siblings of diabetic patients had higher Lp(a) levels (P < 0.001). Parents had higher levels of plasma glucose (P < 0.05) and Lp(a) (P < 0.01). Plasma and RBC-MDA were significantly elevated in diabetic subjects and relatives compared with control subjects. Basal RBC-GSH was lower in diabetic subjects (P < 0.01). In diabetic subjects, incubations of cells caused a decrease in RBC-GSH of a lesser degree than that in control subjects, but they caused a significant increase in hemolysis. Among relatives, hemolysis was increased both at baseline and after incubation. Plasma MDA levels were associated with blood glucose, creatinine, and fibrinogen levels (multiple r = 0.5, P < 0.001), and basal RBC-MDA levels were associated with plasma Lp(a), fibrinogen, and plasma MDA levels (r = 0.6, P < 0.001). Basal RBC-GSH content correlated with serum glucose and RBC-MDA production (r = 0.3, P < 0.01).Our study is the first to present evidence that markers of lipoprotein metabolism (Lp[a]), oxidative stress (plasma and RBC-MDA), and cellular fragility (hemolysis) are abnormal in nondiabetic relatives of type 1 diabetic subjects, thereby supporting the view that familial elements of diabetes even precede the onset of diabetes. It seems reasonable that the same biological markers considered major predictors of cardiovascular disease can also trace familial susceptibility to type 1 diabetes, just as they have been associated with the development of type 2 diabetes.
Role of aberrant WNT signalling in the airway epithelial response to cigarette smoke in chronic obstructive pulmonary disease
Authors: Irene H Heijink, Harold G de Bruin, Maarten van den Berge, Lisa J C Bennink, Simone M Brandenburg, Reinoud Gosens, Antoon J van Oosterhout, Dirkje S Postma
Journal: Thorax (2013)

<h3>Background</h3> WNT signalling is activated during lung tissue damage and inflammation. We investigated whether lung epithelial expression of WNT ligands, receptors (frizzled; FZD) or target genes is dysregulated on cigarette smoking and/or in chronic obstructive pulmonary disease (COPD). <h3>Methods</h3> We studied this in human lung epithelial cell lines and primary bronchial epithelial cells (PBEC) from COPD patients and control (non-)smokers, at baseline and on cigarette smoke extract (CSE) exposure. <h3>Results</h3> CSE significantly decreased WNT-4, WNT-10B and FZD2 and increased WNT-5B mRNA expression in 16HBE, but did not affect WNT-4 protein. The mRNA expression of WNT-4, but not other WNT ligands, was lower in PBEC from smokers than non-smokers and downregulated by CSE in PBEC from all groups, yet higher in PBEC from COPD patients than control smokers. Moreover, PBEC from COPD patients displayed higher WNT-4 protein expression than both smokers and non-smokers. Exogenously added WNT-4 significantly increased CXCL8/IL-8, IL-6, CCL5/RANTES, CCL2/MCP-1 and vascular endothelial growth factor (VEGF) secretion in 16HBE, but did not affect the canonical WNT target genes MMP-2, MMP-9, fibronectin, β-catenin, Dickkopf and axin-2, and induced activation of the non-canonical signalling molecule p38. Moreover, WNT-4 potentiated the CSE-induced upregulation of IL-8 and VEGF. <h3>Conclusions</h3> WNT-4 mRNA and protein levels are higher in PBEC from COPD patients than control (non-)smokers, while cigarette smoke downregulates airway epithelial WNT-4 mRNA, but not protein expression. As WNT-4 further increases CSE-induced pro-inflammatory cytokine release in bronchial epithelium, we propose that higher epithelial WNT-4 levels in combination with cigarette smoking may have important implications for the development of airway inflammation in COPD.
Motivation and morality: Insights into political ideology
Authors: Ronnie Janoff-Bulman, Nate C. Carnes
Journal: Behavioral and Brain Sciences (2014)

Abstract Our past work linking motivation and morality provides a basis for understanding differences in political ideology and positions across the political spectrum. Conservatism is rooted in avoidance-based proscriptive morality, whereas liberalism is rooted in approach-based prescriptive morality. Two distinct, binding, group moralities reflect these different regulatory systems and emphasize social coordination through Social Order versus social cooperation through Social Justice.
Patterns of Coexisting Lesions Detected on Magnetic Resonance Imaging and Relationship to Incident Knee Osteoarthritis: The Multicenter Osteoarthritis Study
Authors: Jingbo Niu, David T. Felson, Tuhina Neogi, Michael C. Nevitt, Ali Guermazi, Frank Roemer, Cora E. Lewis, James Torner, Yuqing Zhang
Journal: Arthritis & Rheumatology (2015)

To identify patterns of coexisting lesions seen on magnetic resonance imaging (MRI) in knees that are free of radiographic osteoarthritis (OA) and to examine the relationship of these MRI-detected lesions to incident OA.Study subjects were individuals enrolled in the Multicenter Osteoarthritis Study, a prospective cohort study. In each subject, 1 knee in which radiographic OA was absent in both the tibiofemoral and patellofemoral joints at baseline was selected for study, with followup for 84 months. We used a novel approach, latent class analysis, to group the constellation of MRI lesions in each joint, i.e., cartilage damage, bone marrow lesion, meniscal tear, meniscal extrusion, synovitis, and effusion, into a manageable number of subgroups. The association of these subgroups with incident radiographic OA in the same joint was assessed using logistic regression.Among 885 eligible knees (203 with incident disease in the tibiofemoral joint, 64 with incident disease in the patellofemoral joint), 4 latent subgroups in the tibiofemoral joint were identified (described briefly as minimal lesions, mild lesions, moderate lesions [but limited meniscal lesions], and severe lesions). The odds ratios of incident tibiofemoral joint OA in the latter 3 subgroups (compared to the knees with minimal lesions as the referent) were 5.6, 1.8, and 5.0, respectively. A similar set of 4 subgroups in the patellofemoral joint was identified, except that the fourth subgroup had limited meniscal lesions. The odds ratios of incident disease in the patellofemoral joint were 3.8, 5.1, and 13.7 in the subgroups with mild lesions, moderate lesions, and severe lesions, respectively.Different patterns of coexisting MRI lesions, which have different implications with regard to risk of knee OA, were identified. Meniscal damage seemed to play a different role in the development of incident disease in tibiofemoral versus patellofemoral joints.
Interactions between antiarrhythmic drugs and cardiac memory
Authors: A Plotnikov
Journal: Cardiovascular Research (2001)

Objective: Ventricular pacing or arrhythmias can induce cardiac memory (CM). We hypothesized that clinically administered antiarrhythmic drugs alter the expression of CM, and that the repolarization changes characteristic of CM can modulate the effects of antiarrhythmic drugs. Methods: We studied conscious, chronically-instrumented dogs paced for two 1-h periods to study the effects of drugs on the evolution of memory (protocol 1) or for 21 days (protocol 2) to observe the effects of steady-state memory on drug actions. Dogs were treated in both settings with quinidine, lidocaine or E4031, in random order, and within therapeutic serum concentration ranges. Results: Pacing, alone, for 2 h significantly prolonged ERP only near the left ventricular pacing site, whereas pacing alone for 21 days prolonged ERP at all sites (P<0.05). Quinidine and E4031, but not lidocaine, prolonged repolarization and ERP and suppressed evolution of CM in protocol 1. However, quinidine's effect in prolonging repolarization was diminished in both protocols, while its effect in prolonging ERP was diminished in the 21-day protocol only. In contrast, the effects of E4031 were additive to those of CM, prolonging repolarization and ERP in both protocols, while lidocaine showed no changes in effect at all. Conclusions: Pacing to induce CM significantly affects ventricular repolarization and refractoriness, and there are interactions between CM, quinidine and E4031. Depending on the specific drug, these interactions have the potential to be anti- or proarrhythmic, and may impact importantly on the clinical efficacy of drugs as well as on electrophysiologic testing of drug actions.
Effect of Vitamin D, Sucrose, Corn Oil and Endocrines on Tissue Cholesterol in Rats
Authors: CHENG-CHUN LEE, ROY G. HERRMANN
Journal: Circulation Research (1959)

A diet containing 65 per cent sucrose with added cholesterol resulted in hypercholesteremia and increased tissue cholesterol deposition in rats. Ten per cent corn oil with added cholesterol in Purina laboratory chow had no apparent effect on the serum total cholesterol but increased cholesterol deposition in tissues. Ovariectomy was without significant effect. Thyroidectomy or hypophysectomy aggravated the hypercholesteremia and the increased tissue cholesterol deposition induced by the sucrose diet. The effect of hypophysectomy was not due to the loss of thyrotrophic hormone alone. Addition of vitamin D aggravated hypercholesteremia and increased liver cholesterol deposition in normal, thyroidectomized or hypophysectomized rats fed the sucrose diet. In ovariectomized rats, the tissue cholesterol deposition was also augmented. When corn oil diet was fed, the supplementary vitamin D increased the serum total cholesterol level of the thyroidectomized rat.
Assessment of the effect of oral corticosteroids on bone mineral density in systemic lupus erythematosus: a preliminary study with dual energy x ray absorptiometry.
Authors: V B Dhillon, M C Davies, M L Hall, J M Round, P J Ell, H S Jacobs, M L Snaith, D A Isenberg
Journal: Annals of the Rheumatic Diseases (1990)

Dual energy x ray absorptiometry and a wide range of blood and urine tests were used to assess the propensity of patients with systemic lupus erythematosus to develop an impairment of bone mineral density. Surprisingly, in this preliminary study no significant differences in bone mineral density were found when patients taking 10 mg or more of prednisolone for six months or longer were compared with those who had never taken prednisolone.