tbuckley/cabot-search huggingface dataset:
Is Helicobacter pylori the cause of dyspepsia?
Authors: B. Bernersen, R. Johnsen, L. Bostad, B. Straume, A. I. Sommer, P. G. Burhol
Journal: BMJ (1992)

To determine the association between infection with Helicobacter pylori and dyspepsia.Cross sectional study of dyspeptic subjects and age and sex matched controls identified by a questionnaire survey of all inhabitants aged 20-69. (Endoscopy, histological examination, and microbiological examinations of biopsies from the gastric mucosa were performed blind.)Population based survey in Sørreisa, Norway.All 782 dyspeptic subjects (excluding those with a previous history of peptic ulcer, gall stones or kidney stones, and coronary heart disease) and controls were offered an endoscopy, of whom 309 dyspeptic subjects and 310 controls attended.Prevalences of endoscopic and histological diagnoses and of cultures positive for H pylori.A high prevalence of positive cultures, increasing with age, was found in both dyspeptic subjects (48%) and non-dyspeptic controls (36%) (p = 0.004). Positive cultures in both dyspeptic subjects and controls were strongly associated with histological gastritis (70%, 95% confidence interval 65.5 to 85.3; 60%, 52.7 to 67.7, respectively) and peptic ulcer (92%, 61.5 to 99.8; 64.1, 9.4 to 99.2, respectively). Only 3% of subjects with a histologically non-inflamed gastric mucosa had this infection (dyspeptic subjects 2%, 0.2 to 7.0; controls 4%; 1.2 to 8.8).The relation between dyspeptic symptoms and H pylori is dubious; H pylori seems to have a pathogenetic role in gastritis and may be a contributing factor but not a cause of peptic ulcer.
Acute Tubular Necrosis in a Patient with March Hemoglobinuria
Authors: Thomas D. Pollard, Ira W. Weiss
Journal: New England Journal of Medicine (1970)

MARCH hemoglobinuria is a hemolytic disorder in which transient hemoglobinemia with hemoglobinuria develops in susceptible persons after strenuous exercise.1 Some patients with this disease have had transient abnormalities of the urinary sediment,2 but other renal impairments have not been reported.3 This report describes the occurrence of acute tubular necrosis in a man with march hemoglobinuria after a marathon race.Case ReportC.B. (M.G.H. 00–64–20), a 37-year-old man, was admitted to the Massachusetts General Hospital because of pigmenturia and oliguria after a 26-mile marathon race. Previously in excellent health and on no medications, he had first begun long-distance running 1 year . . .
Chief medical officer announces regulations on cosmetic surgery
Authors: Katie Reid
Journal: BMJ (2005)

The chief medical officer, Liam Donaldson, announced measures to improve the regulation of private cosmetic surgery last week, after the publication of two reports by the Healthcare Commission and an expert group set up to investigate practice.

Patients are unsure of cosmetic surgeons' qualifications and are not given enough information about the options available and the risks involved, according to the expert group's report. It also found that it was sometimes difficult for patients to make a complaint. …
Oral Treatment of Diabetes
Authors: G. H. Hall, M. F. Crowley, A. Bloom
Journal: BMJ (1958)

<b><i></i></b> The authors searched for mutations in the gene that codes for the α2 chain of type V procollagen in 10 patients with spontaneous cervical artery dissections (sCAD). Two patients carried a missense mutation affecting the predicted C-propeptide (T1227S; D1429V). A third patient carried two mutations (V509A and P830L) in the same α2(V) chain. The T1227S mutation and the V509A/P830L haplotype also were detected among 50 healthy subjects. The D1429V substitution was detected neither in a series of 150 healthy control subjects nor among 50 additional patients with sCAD.
Differential Effects of Eicosapentaenoic Acid and Docosahexaenoic Acid on Vascular Reactivity of the Forearm Microcirculation in Hyperlipidemic, Overweight Men
Authors: Trevor A. Mori, Gerald F. Watts, Valerie Burke, Elisabet Hilme, Ian B. Puddey, Lawrence J. Beilin
Journal: Circulation (2000)

Recent evidence supports differential effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), the 2 major omega3 fatty acids of marine origin, on blood pressure in humans and vascular reactivity in adult spontaneously hypertensive rats. We investigated possible differences in the effects of purified EPA or DHA on forearm vascular reactivity in overweight hyperlipidemic men that might contribute to the blood pressure-lowering effects of fish oils.With a double-blind, placebo-controlled trial of parallel design, 59 overweight, mildly hyperlipidemic men were randomized to receive 4 g/d purified EPA, DHA, or olive oil (placebo) capsules while continuing their usual diets for 6 weeks. Forearm blood flow (FBF) was measured with venous occlusion, strain-gauge plethysmography during the sequential intra-arterial administration of acetylcholine (7.5, 15, and 30 microg/min), sodium nitroprusside (1.5, 3, and 10 microg/min), norepinephrine (10, 20, and 40 ng/min), a single-dose infusion of N:(G)-monomethyl-L-arginine (L-NMMA) (1 mg/min), and coinfusion of acetylcholine (7.5, 15, and 30 microg/min) and L-NMMA. Forty of the 56 subjects who completed the study underwent FBF measurements. Plasma phospholipid EPA levels increased significantly (P:<0.0001) after supplementation with EPA, and DHA composition increased with DHA supplementation (P:<0.0001). Relative to placebo, DHA, but not EPA, supplementation significantly improved FBF in response to acetylcholine infusion (P:=0.040) and coinfusion of acetylcholine with L-NMMA (P:=0.040). Infusion of L-NMMA alone showed no group differences. DHA significantly enhanced dilatory responses to sodium nitroprusside (P:<0.0001) and attenuated constrictor responses to norepinephrine (P:=0.017).Relative to placebo, DHA, but not EPA, enhances vasodilator mechanisms and attenuates constrictor responses in the forearm microcirculation. Improvements in endothelium-independent mechanisms appear to be predominant and may contribute to the selective blood pressure-lowering effect observed with DHA compared with EPA in humans.
Adrenocortical Hyperactivity in a Patient with Bronchial Carcinoma and Diabetes Mellitus
Authors: F. D. Rosenthal
Journal: BMJ (1957)

1957, he said he was much better since taking the tablets, and that he was reminded by discomfort if he did not take them.He has worked regularly during treatment.Case 14.-A man aged 53 had had symptoms for 30 years.In October, 1956, he had a straight rigid dorsal and lumbar spine and slight movement of his neck, which was projected forward.His ribs showed no appreciable movement during respiration.Lumbar spine and sacro-iliac joints were com- pletely ankylosed.His E.S.R. was 25 mm. in 1 hour.He complained of considerable pain in his shoulders and neck.Prednisolone was started in October, and one month later he reported that he was " practically free of pain-more so than for six or seven years"; also that movement of his neck had improved and he felt fully active.His chest expansion was then 1 in.(2.5 cm.).In February, 1957, he reported that pain was negligible, and he thought that movement of his neck had further improved.His chest expansion was 1 in.(3.8 cm.).He had worked continuously as a schoolmaster.His E.S.R. was 5 mm. in 1 hour. SummaryThe response of 14 consecutive patients with advanced and painful ankylosing spondylitis to treatment with corticotrophin, cortisone, and prednisolone is recorded.There has been an appreciable degree of relief of symp- toms, which had not been obtained by other means.The relief of pain was rapid, and was accompanied by some increased freedom of movement.In some cases treat- ment was stopped, with continuing relief.
Testosterone Diminishes the Proarrhythmic Effects of Dofetilide in Normal Female Rabbits
Authors: Thai V. Pham, Eugene A. Sosunov, Evgeny P. Anyukhovsky, Peter Danilo, Michael R. Rosen
Journal: Circulation (2002)

Background— Recent clinical and experimental data suggest that testosterone may protect males against the deleterious effects of repolarization-prolonging drugs. This study tests the hypothesis that 5α-dihydrotestosterone (DHT) protects normal females against drug-induced excessive prolongation of repolarization. Methods and Results— We used microelectrode techniques to study isolated preparations of rabbit ventricular endocardium from age-matched normal control female rabbits and female rabbits treated with DHT for 4 weeks. Serum 17β-estradiol levels were identical in the control and DHT-treated animals, whereas DHT levels were high (equaling those in normal males) only in the DHT-treated animals. Basal action potential duration to 90% repolarization (APD 90 ) was significantly shorter in DHT-treated (155±7.4 ms, n=32) than control females (178±6.7 ms, n=29; P &lt;0.05) at cycle length=1000 ms. The increase in APD 90 induced by 10 −8 mol/L dofetilide at cycle length=1000 ms was significantly less in DHT-treated females than normal females (ΔAPD 90 =8±7 and 29±5 ms, respectively, P &lt;0.05). At 10 −6 mol/L dofetilide, the incidence of early afterdepolarizations was 28% in DHT-treated and 55% in normal female rabbits ( P &lt;0.05). Conclusions— Elevating DHT levels diminishes the effects of dofetilide to increase APD and induce early afterdepolarizations in females. Moreover, treatment of females with DHT results in prolongation of APD and an incidence of early afterdepolarization equal to values previously reported by us for dofetilide-treated normal males. That serum levels of 17β-estradiol were the same in DHT-treated and untreated females suggests that estradiol is not involved in the response to dofetilide. Thus, these data suggest that DHT and perhaps other androgenic hormones may protect normal females against the risk of dofetilide-induced arrhythmia.
Serum gastrin and gastric acid responses to meals at various pH levels in man
Authors: S. J. Konturek, J. Biernat, J. Oleksy
Journal: Gut (1974)

Serum gastrin and gastric acid responses to a test meal of 10% peptone were measured in six duodenal ulcer patients using intragastric titration at pH levels ranging from 5·5 to 1·0. In this way the pH profile for inhibition of serum gastrin release and gastric acid secretion was established. A peptone meal adjusted to pH 5·5 produced gastric acid similar to the maximal response to histamine. A graded decrease of pH of the peptone meal to 1·0 resulted in the progressive inhibition of the gastric acid secretion and the concomitant suppression of the serum gastrin level. Exogenous secretin given in graded doses ranging from 0·25 to 2·0 U/kg-hr caused a dose-related inhibition of gastric acid secretion and the suppression of serum gastrin level. The results of the study indicate that gastric acid secretion and the rise in serum gastrin levels in response to an experimental meal are less when the gastric contents become more acid. The mechanism may involve release of secretin from the small intestine by acid.
ATOPIC ECZEMA IN EUROPEAN AND NEGRO WEST INDIAN INFANTS IN LONDON.
Authors: L. R. DAVIS, R. H. MARTEN, I. SARKANY
Journal: British Journal of Dermatology (1961)

Journal Article ATOPIC ECZEMA IN EUROPEAN AND NEGRO WEST INDIAN INFANTS IN LONDON. Get access L. R. DAVIS, M.D.(Lond.), L. R. DAVIS, M.D.(Lond.) Senior Lecturer in Pathology. Belgrave Hospital for Children, Kings's College Hospital, London, S.E.5 Search for other works by this author on: Oxford Academic Google Scholar R. H. MARTEN, M.A., B.M.(Oxon.), M.R.C.P.(Lond), R. H. MARTEN, M.A., B.M.(Oxon.), M.R.C.P.(Lond) Consultant Dermatologist. Belgrave Hospital for Children, Kings's College Hospital, London, S.E.5 Search for other works by this author on: Oxford Academic Google Scholar I. SARKANY, M.R.C.P.(Lond.) I. SARKANY, M.R.C.P.(Lond.) Senior Registrar in Dermatology. Belgrave Hospital for Children, Kings's College Hospital, London, S.E.5 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 73, Issue 11, 1 November 1961, Pages 410–414, https://doi.org/10.1111/j.1365-2133.1961.tb14988.x Published: 01 November 1961
Cost Containment by a Naval Armada
Authors: James V. Maloney, Keith Reemtsma
Journal: New England Journal of Medicine (1985)

President Reagan assured us that a major objective in invading Grenada was to close the St. George's Medical School (although Russians, Democrats, and M. Mitterand attributed to him more sinister motives). Lingering doubts about his sincerity were resolved when, as the fighting wound down, he gave a luncheon party in the Rose Garden for the entire student body.The closure of a medical school by a naval armada highlights the principal problem we have in containing the cost of health care: We are facing a glut of doctors, the consequence of which will be enormous costs without commensurate improvement in . . .
Predation versus competition and the importance of manipulable causes
Authors: Katy Tapper
Journal: Behavioral and Brain Sciences (2006)

It is difficult to fully account for (1) cruelty in modern society and (2) female cruelty, referring only to a cruelty-satiation association. Instead it seems likely that cruelty acquires its reinforcing value via association with a range of reinforcers. In addition, when one's goal is violence prevention, it is important to identify causes that can be manipulated.
The fate of fetal and adult B-cell progenitors grafted into immunodeficient CBA/N mice.
Authors: C J Paige, P W Kincade, M A Moore, G Lee
Journal: The Journal of Experimental Medicine (1979)

The relative ability of various precursors to generate functional B cells in vivo was assessed by transferring normal, chromosomally-marked CBA/H-T6T6 cells to irradiated or unirradiated immunodeficient CBA/N mice. Emergence of donor-derived B cells was monitored by means of a B-cell cloning assay (in which CBA/N cells are inactive), and by karyotpic analysis of lymphoid, myeloid, and stem cell metaphases. Grafts of lymph node, spleen, anti-mu surface immunoglobin suppressed bone marrow, sIg+ cell-depleted marrow, normal marrow, fetal liver, and yolk sac suggest: (a) there is little self-renewal of sIg+ B cells in these models; (b) pre-committed cells have extensive proliferative/differentiative potential and at least initially contribute most of the newly-formed B cells; (c) populations or pre-B cells obtained from various sources differ in their regenerative ability; (d) CBA/N mice are deficient in a category of pre-B cells which are found in fetal liver; and (e) selective B-cell chimerism results from grafting of unirradiated CBA/N mice.
Type A Behavior Pattern and Mortality after Recurrent Myocardial Infarction: Preliminary Results from a Follow-Up Study of 5 Years
Authors: Diego De Leo, Stefano Caracciolo, Fiorenza Berto, Pia Mauro, Guido Magni, Giuseppe Miraglia
Journal: Psychotherapy and Psychosomatics (1986)

The purpose of the current study is to examine the association between the type A Behavior Pattern (TABP) and recurrent myocardial infarction (RMI). Rosenman's Structured Interview was administered to a consecutive series of patients admitted to the hospital for myocardial infarction (n = 88). Incidence and mortality from RMI in relation to TABP categories were evaluated after a follow-up period of 5 years. The number of new episodes of myocardial infarction observed in the extreme categories was nearly the same but the number of subjects who died was nearly twice as large in the B as in the A1 category (10.3% vs. 5.8%, χ2 = 9.074, p < 0.0283). No subject was observed to survive after RMI in the B group. In agreement with other recent studies, our preliminary results failed to confirm the association between TABP and RMI, but showed a protection from death for subjects displaying high TABP levels. This finding is discussed in terms of the possibility for type A subjects to cope better with the acute illness.
E148Q is a disease-causing MEFV mutation: a phenotypic evaluation in patients with familial Mediterranean fever
Authors: R Topaloglu
Journal: Annals of the Rheumatic Diseases (2004)

Familial Mediterranean fever (FMF) is one of the periodic fever syndromes. It is common among Turks, Jews, Arabs, and Armenians. Several mutations in the MEFV gene, including E148Q, have been identified as causing this disease. It has been suggested that the E148Q mutation is the mildest mutation and some reports have questioned its disease association.To evaluate the phenotypic features of the patients with E148Q mutation.26 patients homozygous for E148Q, 10 compound heterozygous for E148Q, and eight complex cases were assessed.Although four of the 26 patients with E148Q/E148Q were asymptomatic at the time of evaluation, abdominal pain was seen in 77% of the patients, fever in 66%, arthralgia in 50%, arthritis in 15.4%, and vomiting in 23.8%. Compound heterozygotes and complex cases had a higher frequency of abdominal pain, fever, arthralgia, arthritis, myalgia, and chest pain than subjects who were homozygous for E148Q, but none of these symptoms reached statistical significance. None of our patients had amyloidosis but two with E148Q/E148Q had a family history of amyloidosis and one had rapidly progressive glomerulonephritis secondary to vasculitis, which progressed to chronic renal failure.Patients homozygous for E148Q have a heterogeneous clinical presentation. Most are symptomatic and colchicine treatment is required in these patients.
(32) Ichthyosiform erythroderma treated with etretinate
Authors: D. Burrows
Journal: British Journal of Dermatology (1984)

Journal Article (32) Ichthyosiform erythroderma treated with etretinate Get access D. Burrows D. Burrows Royal Victoria Hospital, Belfast Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 111, Issue s26, 1 July 1984, Page 76, https://doi.org/10.1111/j.1365-2133.1984.tb05302.x Published: 01 July 1984
Caveolin-1 Is Required for Vascular Endothelial Growth Factor-Triggered Multiple Myeloma Cell Migration and Is Targeted by Bortezomib
Authors: Klaus Podar, Reshma Shringarpure, Yu-Tzu Tai, Melissa Simoncini, Martin Sattler, Kenji Ishitsuka, Paul G. Richardson, Teru Hideshima, Dharminder Chauhan, Kenneth C. Anderson
Journal: Cancer Research (2004)

Abstract We recently demonstrated that caveolae, vesicular flask-shaped invaginations of the plasma membrane, represent novel therapeutic targets in multiple myeloma. In the present study, we demonstrate that vascular endothelial growth factor (VEGF) triggers Src-dependent phosphorylation of caveolin-1, which is required for p130Cas phosphorylation and multiple myeloma cell migration. Conversely, depletion of caveolin-1 by antisense methodology abrogates p130Cas phosphorylation and VEGF-triggered multiple myeloma cell migration. The proteasome inhibitor bortezomib both inhibited VEGF-triggered caveolin-1 phosphorylation and markedly decreased caveolin-1 expression. Consequently, bortezomib inhibited VEGF-induced multiple myeloma cell migration. Bortezomib also decreased VEGF secretion in the bone marrow microenvironment and inhibited VEGF-triggered tyrosine phosphorylation of caveolin-1, migration, and survival in human umbilical vascular endothelial cells. Taken together, these studies demonstrate the requirement of caveolae for VEGF-triggered multiple myeloma cell migration and identify caveolin-1 in multiple myeloma cells and human umbilical vascular endothelial cells as a molecular target of bortezomib.
Antithrombin III prevents concanavalin A-induced liver injury through inhibition of macrophage inflammatory protein-2 release and production of prostacyclin in mice
Authors: Kimihide Nakamura, Taku Ito, Masashi Yoneda, Shujiro Takamoto, Yukiomi Nakade, Satoshi Okamoto, Mitsuyoshi Okada, Shiro Yokohama, Kazunobu Aso, Isao Makino
Journal: Journal of Hepatology (2002)
Minister urges reduction in juniors' working hours BMA says rabies rules should stay All career registrars will transfer to specialist registrar grade Community care is blocking beds, doctors say
Authors: L. Beecham
Journal: BMJ (1995)

# Minister urges reduction in juniors' working hours {#article-title-2}

The minister for health, Mr Gerald Malone, has told chairmen of trusts, district health authorities, and family health services authorities that he will adhere to the target in the new deal on junior doctors' hours that all non-hard pressed on call posts contracted for more than 72 hours will be eliminated by December 1996. Although the target date for eliminating hard pressed posts contracted for over 72 hours was December 1994 the minister has admitted that 764 juniors were still in such posts in February.

He has asked chairmen to concentrate on reducing the actual working hours of junior hospital doctors. He says in a letter earlier this month that doctors should not be asked to undertake hours of duty that made it inevitable that they would work longer than 56 hours a week--for example, through early starts and late finishes. He has asked chairmen to look at the arrangements and relationships of all the staff in a department to achieve this aim. Mr Malone points out that the only satisfactory way to ensure that juniors did not work too long was to secure proper rest periods, which were not constantly interrupted.

The minister admits that partial shifts were unpopular with some doctors and managers but he suggests that this might be the appropriate working pattern to avoid unacceptable work intensity of on call rotas. Regional taskforces will be asked to work with chairmen to disseminate good practice on partial shifts.

Mr Malone has emphasised the importance of involving juniors in monitoring, implementing, and developing new working practices.

The minister has also pointed out that purchasers have a direct interest in …
Postmarketing surveillance of enalapril. I: Results of prescription-event monitoring.
Authors: W. H. Inman, N. S. Rawson, L. V. Wilton, G. L. Pearce, C. J. Speirs
Journal: BMJ (1988)

To identify and measure the incidence of adverse effects of the angiotensin converting enzyme inhibitor enalapril 13,713 patients were studied for one year by prescription-event monitoring. Precise information about the duration of treatment was available for 12,543 patients. The frequency of many events was calculated, including dizziness (483 patients; 3.9%), persistent dry cough (360; 2.9%), headache (310; 2.5%) hypotension (218; 1.7%), and syncope (155; 1.2%). Less common reactions included angioedema, urticaria, and muscle cramps. Altogether 1098 (8%) patients died and the notes of 913 of them (83%) were obtained for detailed scrutiny. With the exception of a few patients with renal failure who deteriorated during treatment (reported on separately), no death was attributed to enalapril. Enalapril was considered to be effective, even in patients with advanced cardiac failure. These results for enalapril are reassuring and provide further evidence of the value of prescription-event monitoring.
A Quantitative Nonimmunogenic Transgene Product for Evaluating Vectors in Nonhuman Primates
Authors: Philip W. Zoltick, James M. Wilson
Journal: Molecular Therapy (2000)

The success of gene therapy depends on safe, effective vectors to transfer genetic information. We have developed a means to quantitatively assess efficacy of gene transfer vectors by using a biologically inert, secreted reporter molecule, the beta chain of chorionic gonadotropin (beta-CG). Using an isogenic beta chain subunit of CG in a recombinant adeno-associated virus (rAAV) vector, overall gene transfer of rhesus macaque muscle is demonstrated over time by measuring the serum concentration of beta-CG. Endogenous levels of gonadotropins are not detectable in healthy, nonpregnant primates as confirmed by the inability to detect serum levels of beta-CG prior to vector administration. The serum concentration of beta-CG also provides a measure for the transfer efficiency in liver and/or muscle in immunodeficient mice using recombinant adenovirus and rAAV vectors. No biological effect was observed in animals tested. Assaying for the serum level of beta-CG serves as a surrogate quantitative marker of gene transfer without interfering with the biology of the host or transduction process.