Prolonged Arthritis in Identical Twins After Rubella Immunization
Authors: AUBREY J. TINGLE
Journal: Annals of Internal Medicine (1979)

Brief Reports1 February 1979Prolonged Arthritis in Identical Twins After Rubella ImmunizationAUBREY J. TINGLE, M.D., Ph.D., DENYS K. FORD, M.D., GEORGE E. PRICE, M.D., DONALD W. G. KETTYLS, M.D.AUBREY J. TINGLE, M.D., Ph.D.Search for more papers by this author, DENYS K. FORD, M.D.Search for more papers by this author, GEORGE E. PRICE, M.D.Search for more papers by this author, DONALD W. G. KETTYLS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-2-203 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe development of transient or recurrent arthritis has been reported after either wild-type rubella infection or immunization with the HPV-77 DK/12 or, more rarely, the HPV-77 DE/5 strain of rubella vaccine (1-3). We describe the development of prolonged arthritis in identical female twins after HPV-77 DE/5 rubella immunization and report on virologic and immunologic studies carried out prospectively on one of the twins. The results support the hypothesis that abnormalities in the regulation of immunologic response to rubella virus play an important role in the development of rubella-associated arthritis.In February 1976 an identical twin woman 29 years of age...References1. SPRUANCEMETCALFSMITHGRIFFITHSWARD SRCMJ: Chronic arthropathy associated with rubella vaccination. Arthritis Rheum 20:741-747, 1977 CrossrefMedlineGoogle Scholar2. THOMPSONWEISSSHILLISBRACKETT GJJR: Intermittent arthritis following rubella vaccination. A three-year follow-up. Am J Dis Child 125:526-530, 1973 CrossrefMedlineGoogle Scholar3. CHIBASADEGHIOGRA YEP: Abnormalities of cellular immune response in arthritis induced by rubella vaccination. J Immunol 117:1684-1687, 1976 MedlineGoogle Scholar4. SMITHCHESSMARDINEY KLM: The relationship between rubella hemagglutination inhibition antibody (HIA) and rubella induced in vitro lymphocyte tritiated thymidine incorporation. Cell Immunol 8:321-327, 1973 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: AUBREY J. TINGLE, M.D., Ph.D.; DENYS K. FORD, M.D.; GEORGE E. PRICE, M.D.; DONALD W. G. KETTYLS, M.D.Affiliations: University of British Columbia Vancouver, British Columbia Canada PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRandomised double-blind placebo-controlled study on adverse effects of rubella immunisation in seronegative womenAdult onset Still's disease and viral infections.Purification of biologically active rubella virus antigens by immunoaffinity chromatographyInfection and interferon production in systemic juvenile chronic arthritis: a prospective study.Orthopedic surgeryNeurological complications of immunizationPERSISTENT RUBELLA INFECTION AND RUBELLA-ASSOCIATED ARTHRITISRubella-Associated Arthritis: Rescue of Rubella Virus from Peripheral Blood Lymphocytes Two Years PostvaccinationVirus-Host Interactions and the Connective Tissue DiseasesAcute ArthritisArthritis associated with common viral infectionsArthritis related to rubella 1 February 1979Volume 90, Issue 2Page: 203-204KeywordsArthritisMedical servicesMonozygotic twinsProspective studiesRubellaRubella vaccineTwins ePublished: 1 December 2008 Issue Published: 1 February 1979 Copyright & Permissions©1979 American College of PhysiciansPDF downloadLoading ...