tbuckley/cabot-search huggingface dataset:
Angina, “Normal” Coronary Angiography, and Vascular Dysfunction: Risk Assessment Strategies
Authors: Raffaele Bugiardini, Lina Badimon, Peter Collins, Raimund Erbel, Kim Fox, Christian Hamm, Fausto Pinto, Annika Rosengren, Christodoulos Stefanadis, Lars Wallentin, Frans Van de Werf
Journal: PLoS Medicine (2007)

Chest pain may be associated with coronary arteries that appear “normal.” Normal is defined here as no visible disease or luminal irregularities (less than 50%) as judged visually at coronary angiography. Normal angiography in patients with chest pain is five times more common in women than in men [1]. Among patients with chest pain and normal angiography, an unknown number are suffering from cardiac pain of ischemic origin. Uncertainty is often difficult to allay, for medical attendants as well as for patients, resulting in perpetuation of symptoms, difficulties in management, and establishment of risk of subsequent coronary events [2]. In this article, we discuss how to stratify risk in patients with chest pain and a normal coronary angiogram. We based our article on a literature review, using the key words “angina with normal angiography,” “angina with normal coronary arteries,” “non-obstructive coronary disease,” or “chest pain of non-cardiac origin,” plus “[a]etiology,” “pathophysiology,” “diagnosis,” “classification,” “prognosis,” or “therapy.” A longer, more detailed version of this paper is found in the supplementary file S1.
[184] LIVER TRANSPLANTARION FOR FAMILIAL AMYLOID POLYNEUROPATHY. TEN YEARS EXPERIENCE OF HOSPITAL ARGERICH (ARGENTINA)
Authors: P. Trigo, E. Varela, G. Aballay, G. Braslasky, N. Cejas, P. Barros Schelotto, C. Romero, A. Oks, G. Cueto, D. Rodriguez, J. Lendoire, O. Imventarza
Journal: Journal of Hepatology (2007)
Fanconi anemia group J mutation abolishes its DNA repair function by uncoupling DNA translocation from helicase activity or disruption of protein-DNA complexes
Authors: Yuliang Wu, Joshua A. Sommers, Avvaru N. Suhasini, Thomas Leonard, Julianna S. Deakyne, Alexander V. Mazin, Kazuo Shin-ya, Hiroyuki Kitao, Robert M. Brosh
Journal: Blood (2010)
Diffuse Bone Marrow Metastases Observed Incidental to Liver-Spleen Imaging
Authors: RICHARD J. CAMPEAU, D G K VARMA, TSUNEO HIRANO, DEBRA A. McARTHUR
Journal: Clinical Nuclear Medicine (1988)

Bone/bone marrow metastases from islet cell carcinoma of the pancreas is extremely rare. The authors show a case of non-functioning islet cell carcinoma metastatic to bone/bone marrow that was noted incidental to liver spleen imaging. A subsequent bone scan revealed increased Tc-99m MDP activity in the precise areas of photon deficits on the Tc-99m SC study.
Acne vulgaris in the elderly: the response to low-dose isotretinoin
Authors: None Seukeran, None Cunliffe
Journal: British Journal of Dermatology (1998)

There is a very small number of patients who suffer from acne even in the sixth and seventh decades of life. These patients have suffered from acne for most of their lives, 30-60 years, and have often received multiple courses of antibiotics over many years. We saw 10 such patients over 4 years. One received oral isotretinoin 1 mg/kg per day, but was unable to tolerate the adverse effects of cheilitis and developed hyperlipidaemia. We subsequently treated nine others with oral isotretinoin, 0.25 mg/kg per day, for 6 months; in six the acne had virtually cleared by 3-4 months while the other three cleared by 6 months. Up to 36 months after therapy these patients have remained clear of acne except for one who relapsed after 11 months. Therefore, as these patients respond well with few side-effects both in the long- and short-term to low-dose isotretinoin, they should be treated with isotretinoin, although at the lower starting dose of 0.25 mg/kg per day compared with younger patients who are treated with 0.5-1 mg/kg per day, and the treatment maintained for 6 months.
EVALUATION OF COMBINED CORAMINE-ELECTROSHOCK THERAPY IN THE TREATMENT OF SCHIZOPHRENIA
Authors: P. W. K. LIGTHART, R. P. JOHNSTON, E. SUSSMAN
Journal: American Journal of Psychiatry (1956)

1. Thirteen schizophrenic female patients from among consecutive new admissions were given 5 c. c. coramine in conjunction with their regular series of EST, and a roughly comparable group of 13 patients received saline injections with their EST. 2. These patients were given the Wechsler-Bellevue Intelligence Scale and the Bender-Gestalt test just prior to their shock series and were retested 5 weeks following their last treatment. 3. Results indicate that EST used in conjunction with coramine significantly decreased the time spent in EST treatment. Patients receiving coramine returned to a higher level of intellectual functioning and more adequately perceived reality than did their controls as measured by psychological tests. 4. It is hypothesized that coramine-EST brings about an increased blood flow and thalamic stimulation occurs with most of the results being similar in quality, but greater in quantity, to those with standard EST. The one major qualitative difference noted in contrast with standard EST treatment was the lowering of inadequate defenses. The use of coramine-EST makes "intensivetreatment EST" for excited patients unnecessary, thereby avoiding the undesirable post treatment confusion and clinical organic symptoms. 5. Coramine-EST patients experience less fear and appear more receptive to psychotherapy. Acutely ill new admissions benefit most. 6. This is a pilot study and the results should be considered tentative in view of the size of our sample. A 2-year follow-up of these patients would be necessary to draw any definite conclusions as to the permanency of the effects of coramine-EST. The marked tendency in favor of the coramine-EST group does, however, warrant further investigation of coramine as a variation in EST.
Cystin, a novel cilia-associated protein, is disrupted in the cpk mouse model of polycystic kidney disease
Authors: Xiaoying Hou, Michal Mrug, Bradley K. Yoder, Elliot J. Lefkowitz, Gabriel Kremmidiotis, Peter D’Eustachio, David R. Beier, Lisa M. Guay-Woodford
Journal: Journal of Clinical Investigation (2002)

The congenital polycystic kidney (cpk) mutation is the most extensively characterized mouse model of polycystic kidney disease (PKD). The renal cystic disease is fully expressed in homozygotes and is strikingly similar to human autosomal recessive PKD (ARPKD), whereas genetic background modulates the penetrance of the corresponding defect in the developing biliary tree. We now describe the positional cloning, mutation analysis, and expression of a novel gene that is disrupted in cpk mice. The cpk gene is expressed primarily in the kidney and liver and encodes a hydrophilic, 145–amino acid protein, which we term cystin. When expressed exogenously in polarized renal epithelial cells, cystin is detected in cilia, and its expression overlaps with polaris, another PKD-related protein. We therefore propose that the single epithelial cilium is important in the functional differentiation of polarized epithelia and that ciliary dysfunction underlies the PKD phenotype in cpk mice.
Prevention of Rheumatic Fever
Authors: FLOYD W. DENNY, ELIA M. AYOUB, HUGH C. DILLON, FRANK A. DISNEY, EDWARD L. KAPLAN, MAX D. MOODY, PHILIP Y. PATERSON, ANGELO TARANTA
Journal: Circulation (1971)

Rheumatic fever is a recurrent disease which frequently can be prevented. Infection with group A streptococci precipitates both initial and recurrent attacks; therefore, prevention of rheumatic fever and rheumatic heart disease depends upon the control of streptococcal infections. This may be accomplished by (1) prevention of streptococcal injections in rheumatic subjects, and (2) early and adequate treatment of streptococcal infections in all individuals. Bacterial endocarditis may result from dental and other surgical procedures in patients with rheumatic or congenital heart disease. When such procedures are undertaken, these patients should be protected by administration of antibiotics in therapeutic doses.
Antibodies to chlamydial heat shock protein 60 is associated with coronary artery disease but antibodies to human heat shock protein 60 and escherichia coli homologs are not
Authors: Olaimatu S.M. Mahdi, Benjamin D. Horne, Kelly Muellen, Joseph B. Muhlestein, Gerald I. Byrne
Journal: Journal of the American College of Cardiology (2002)
Hepatitis B Markers Among Michigan Prisoners
Authors: MATTHEW L. KAUFMAN
Journal: Annals of Internal Medicine (1983)

Letters and Corrections1 April 1983Hepatitis B Markers Among Michigan PrisonersMATTHEW L. KAUFMAN, M.D., KENNETH L. FAIVER, M.P.H., JAY K. HARNESS, M.D.MATTHEW L. KAUFMAN, M.D.Search for more papers by this author, KENNETH L. FAIVER, M.P.H.Search for more papers by this author, JAY K. HARNESS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-98-4-558_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: It has been suggested that incarcerated persons are at considerable risk of contracting hepatitis B virus infection (1). If one were to assume that a large number of prisoners have acquired natural immunity to this disease from previous infection, a relatively low transmission rate may be expected among prisoners. Unfortunately there are no conclusive data on the extent of hepatitis B carriage, natural immunity, or rate of transmission among incarcerated persons in the United States.Prisoners derive largely from lower socioeconomic groups, and include persons who have been drug abusers, are often tatooed (especially by amateurs), and...References1. . Recommendations of the immunization practices advisory committee: inactivated hepatitis B virus vaccine. Morbid Mortal Weekly Rep. 1982;31:317-28. MedlineGoogle Scholar2. MAYNARD J. Prevention of hepatitis B through the use of vaccine. Ann Intern Med. 1982;97:442-4. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MATTHEW L. KAUFMAN, M.D.; KENNETH L. FAIVER, M.P.H.; JAY K. HARNESS, M.D.Affiliations: Michigan Department of Corrections Lansing, MI 48909 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHeterogeneity in Hepatitis B Virus (HBV) Seroprevalence Estimates from U.S. Adult Incarcerated PopulationsHIV and Viral Hepatitis in Corrections: A Public Health OpportunityPrevention of Viral HepatitisPrevalence of markers for hepatitis B and hepatitis D in a municipal house of correction.Influenza epidemics and anencephaly.Hepatitis B in Wisconsin male prisoners: considerations for serologic screening and vaccination.Incidence of hepatitis B in the penitentiary of New Mexico. 1 April 1983Volume 98, Issue 4Page: 558-558KeywordsAddictsHepatitis BImmunityInfectious diseases ePublished: 1 December 2008 Issue Published: 1 April 1983 PDF downloadLoading ...
CDK4 coexpression with Ras generates malignant human epidermal tumorigenesis
Authors: Mirella Lazarov, Yoshiaki Kubo, Ti Cai, Maya Dajee, Masahito Tarutani, Qun Lin, Min Fang, Shiying Tao, Cheryl L. Green, Paul A. Khavari
Journal: Nature Medicine (2002)
AIDS Vaccines
Authors: John R. Mascola, John G. McNeil, Donald S. Burke
Journal: JAMA (1994)

Worldwide, the human immunodeficiency virus type 1 (HIV-1) has already infected 10 million to 15 million people. With an estimated 5000 to 10 000 new infections occurring each day, 30 million to 40 million people will be infected by the year 2000. 1 In developing countries, where more than 80% of new infections are occurring, the virus is predominantly transmitted heterosexually and is broadly dispersed in general populations. Vaccines that will prevent HIV-1 disease and abrogate virus transmission must be viewed as critical components of a comprehensive public health strategy designed to combat the acquired immunodeficiency syndrome (AIDS) and slow the global spread of HIV-1 infection.  See also p 475.  Although most effective viral vaccines are based on either live attenuated (eg, measles) or inactivated (eg, influenza) virus products, research strategies for HIV-1 vaccine development have focused primarily on the viral envelope glycoproteins gp 120 and gp 160. This focus
Group Psychotherapy with Addicted Smokers
Authors: L.P. Bozzetti
Journal: Psychotherapy and Psychosomatics (1972)

The addicted or problem cigarette smoker presents complex and severe psychological challenges to the psychotherapist. These persons stress the tolerance of their close family members to the limit as they attempt to intervene in this area of destructive behavior. Most often these smokers present themselves to a psychotherapist with the defiant attitude: 'Now, see if you can do something about my smoking!' This study presents the course of treatment of 14 chronic, severely addicted smokers in group therapy over a period of one year. In essence the 7 women of the group smoked in order to handle hostility – especially toward close family members-while the men smoked as a way of coping with dependent, passive feelings. The interactions involved, and their implications in treatment and prognosis, are presented.
Government is not taking responsibility for improving air quality, MPs say
Authors: I. Torjesen
Journal: BMJ (2011)

The government is putting the health of people living in UK cities at risk by trying to water down European Union rules on air quality rather than implementing them as a priority, says parliament’s environmental watchdog.

A report by the House of Commons Environmental Audit Committee published on 14 November says that, despite a commitment by the coalition government to work towards full compliance with EU air quality standards, ministers seem to be actively trying to dilute safety standards to avoid EU fines.

Dangerous levels of particulate matter and pollutants such as nitrogen dioxide are shortening the lives of up to 200 000 people in the United Kingdom by up to two years, the report says. In 2008 around 30 000 deaths …
US advisory panel's chairman calls for reversal of breast implant decision
Authors: F. Charatan
Journal: BMJ (2003)

A decision to restore the marketing of silicone breast implants hangs in the balance after a senior medical adviser has called for the move to be reversed.

In an unprecedented step, the chairman of the advisory panel on medical devices to the US Food and Drug Administration, Dr Thomas Whalen, wrote at the end of October to the agency's commissioner, Dr Mark McLellan, and five congressman, urging them to ignore the panel's recommendation.

In October the panel had voted by nine to six in favour of lifting the agency's 1992 ban …
Abstract 689: Methylation of miRNA genes is a useful biomarker for detection of bladder cancer.
Authors: Hiromu Suzuki, Takashi Shimizu, Masanori Nojima, Eiichiro Yamamoto, Reo Maruyama
Journal: Cancer Research (2013)

Abstract Background and aim: Dysregulation of microRNAs (miRNAs) has been implicated in bladder cancer (BCa), though the mechanism is not fully understood. We aimed to explore the involvement of epigenetic alteration of miRNA expression in bladder cancer. Materials and methods: Two BCa cell lines (T24 and UM-UC-3) were treated with 5-aza-2’deoxycytidine (5-aza-dC) and 4-phenylbutyric acid (PBA), after which their miRNA expression profiles were analyzed using a TaqMan Array. Bisulfite pyrosequencing was used to assess miRNA gene methylation in 5 cancer cell lines, 83 primary tumors, and 120 preoperative and 47 postoperative urine samples. Receiver operating characteristic curve analysis was used to assess the diagnostic performance of the miRNA gene panel. Results: Of 664 miRNAs examined, 146 were upregulated by 5-aza-dC plus PBA. CpG islands were identified in the proximal upstream of 23 miRNA genes, and 12 of those were hypermethylated in cell lines. Among them, miR-137, -124-2, -124-3 and -9-3 were frequently and tumor-specifically methylated in primary cancers (miR-137, 68.7%; miR-124-2, 50.6%; miR-124-3, 65.1%; miR-9-3, 45.8%). Methylation of the same four miRNAs in urine specimens enabled BCa detection with 81% sensitivity and 89% specificity; the area under the ROC curve was 0.916. Ectopic expression of silenced miRNAs in BCa cells suppressed growth and cell invasion. Conclusions: Our results indicate that epigenetic silencing of miRNA genes may be involved in the development of BCa and that methylation of miRNA genes could be a useful biomarker for cancer detection. Citation Format: Hiromu Suzuki, Takashi Shimizu, Masanori Nojima, Eiichiro Yamamoto, Reo Maruyama. Methylation of miRNA genes is a useful biomarker for detection of bladder cancer. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 689. doi:10.1158/1538-7445.AM2013-689
Design and validation of a bedside decision instrument to elicit a patient's preference concerning allogenic bone marrow transplantation in chronic myeloid leukemia
Authors: C. Sebban, G. Browman, A. Gafni, G. Norman, M. Levine, D. Assouline, D. Fiere
Journal: American Journal of Hematology (1995)

Abstract The objective of this study was to design and validate a bedside decision instrument to be used by patients with chronic myeloid leukemia and their physicians in deciding between the therapeutic alternatives of bone marrow transplantation and conservative management during the early phase of disease. A decision board was constructed containing detailed scenarios associated with the treatment alternatives, together with estimates of survival probabilities at various periods of followup. The instrument was tested on 42 healthy hospital personnel and validated by measuring the extent to which systematic alterations in the scenarios with respect to toxicities and survival probabilities produced predicted shifts in treatment preferences. A subgroup of respondents was randomized to receive information through the decision board alone or a shorter and less informative version of the instrument, followed by the decision board. The direction and strength of stated preferences were compared, together with satisfaction for these preferences. The direction and strength of preferences between bone marrow transplantation or conservative chemotherapy were influenced in a predictable way by changes in the toxicity and survival descriptions in the scenarios. Using the test‐retest method in 16 subjects, the stated preferences were found to be highly reliable (intraclass correlation coefficient, 0.87). The mean level of satisfaction with the stated preference, on a scale from not at all satisfied = 1 to very satisfied = 5, was higher for those exposed to the decision board (3.7, SD 1.06) compared with those presented with the short version (2.95, SD 0.67) ( p &lt; 0.01). The results demonstrate the feasibility and acceptability of the instrument in healthy individuals. The preferences elicited by the instrument appear to be reliable and valid according to prespecified constructs of the relation between the information provided and the preferences predicted. These results support further testing of this approach in actual patients. © 1995 Wiley‐Liss, Inc.
Differential expression of hDAB2IPA and hDAB2IPB in normal tissues and promoter methylation of hDAB2IPA in hepatocellular carcinoma
Authors: Guo-Hua Qiu, Huangming Xie, Nicholas Wheelhouse, David Harrison, George G. Chen, Manuel Salto-Tellez, Paul Lai, James A. Ross, Shing Chuan Hooi
Journal: Journal of Hepatology (2006)
Is Long-Term Use of Antismoking Drugs Consistent with Public Health Goals or Pharmaceutical Marketing Goals?
Authors: Adriane J. Fugh-Berman
Journal: Annals of Internal Medicine (2008)

Letters2 December 2008Is Long-Term Use of Antismoking Drugs Consistent with Public Health Goals or Pharmaceutical Marketing Goals?Adriane J. Fugh-Berman, MD and Douglas Melnick, MD, MPHAdriane J. Fugh-Berman, MDFrom Georgetown University Medical Center, Washington, DC 20057, and Los Angeles, CA 91602.Search for more papers by this author and Douglas Melnick, MD, MPHFrom Georgetown University Medical Center, Washington, DC 20057, and Los Angeles, CA 91602.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-149-11-200812020-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:A recent article by Steinberg and colleagues (1) argues that tobacco dependence should be considered a medical disease, like asthma or diabetes. Steinberg and colleagues argue that the smoking habit deserves chronic disease status, and that long-term drug treatment, despite being an off-label use, should be reimbursed.Smokers should be encouraged and supported to quit smoking, with short-term pharmacologic aids if necessary. Long-term use of products that have not been tested or approved for long-term use, however, is inconsistent with public health goals while being consistent with pharmaceutical marketing goals. We note that 2 authors of the ...Reference1. Steinberg MB, Schmelzer AC, Richardson DL, Foulds J. The case for treating tobacco dependence as a chronic disease. Ann Intern Med. 2008;148:554-6. [PMID: 18378950] LinkGoogle Scholar Author, Article, and Disclosure InformationAuthors: Adriane J. Fugh-Berman, MD; Douglas Melnick, MD, MPHAffiliations: From Georgetown University Medical Center, Washington, DC 20057, and Los Angeles, CA 91602.Disclosures: Dr. Fugh-Berman has been a paid expert witness on the plaintiff's side in litigation regarding pharmaceutical marketing practices. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Case for Treating Tobacco Dependence as a Chronic Disease Michael B. Steinberg , Amy C. Schmelzer , Donna L. Richardson , and Jonathan Foulds Is Long-Term Use of Antismoking Drugs Consistent with Public Health Goals or Pharmaceutical Marketing Goals? Michael B. Steinberg Metrics 2 December 2008Volume 149, Issue 11Page: 838KeywordsAsthmaConflicts of interestDrug marketingDrugsNicotinePrevention, policy, and public healthSmoking cessationSmoking habitsVaccines ePublished: 2 December 2008 Issue Published: 2 December 2008 Copyright & PermissionsCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...