tbuckley/cabot-search huggingface dataset:
Occupationally related respiratory symptoms in trout‐processing workers
Authors: D. Sherson, I. Hansen, T. Sigsgaard
Journal: Allergy (1989)

All eight production workers from a small trout‐processing factory were studied because of respiratory or rhinitis symptoms when working next to the automatic gutting machine. Seven of the eight had positive histamine provocation tests. Four patients had elevated total IgE levels while one had a slightly elevated eosinophil count. All workers had either weakly or moderately positive RAST against contaminated water from the outlet drain of the gutting machine. This water contained 1 μg endotoxin/ml. We concluded that five of the workers had probably developed occupationally related asthma from inhalation of contaminated aerosol from the gutting machine. Inhalation of endotoxin from gram‐negative bacteria may be the cause of this disorder. An alternative explanation is a Type I allergy caused by fish or bacterial protein with or without a simultaneous effect of endotoxin.
Expiratory Flow Limitation and Intrinsic Positive End-Expiratory Pressure at Zero Positive End-Expiratory Pressure in Patients with Adult Respiratory Distress Syndrome
Authors: ANTONIA KOUTSOUKOU, APOSTOLOS ARMAGANIDIS, CRISTIE STAVRAKAKI-KALLERGI, THEODOROS VASSILAKOPOULOS, ANDREAS LYMBERIS, CHARIS ROUSSOS, JOSEPH MILIC-EMILI
Journal: American Journal of Respiratory and Critical Care Medicine (2000)

It has been suggested that in patients with adult respiratory distress syndrome (ARDS), intrinsic positive end-expiratory pressure (PEEPi) is generated by a disproportionate increase in expiratory flow resistance. Using the negative expiratory pressure (NEP) technique, we assessed whether expiratory flow limitation (EFL) and PEEPi were present at zero PEEP in 10 semirecumbent, mechanically ventilated ARDS patients. Because bronchodilators may decrease airway resistance, we also investigated the effect of nebulized salbutamol on EFL, PEEPi, and respiratory mechanics in these patients, and in seven patients we measured the latter variables in the supine position as well. In the semirecumbent position, eight of the 10 ARDS patients exhibited tidal EFL, ranging from 5 to 37% of the control tidal volume (Vt), whereas PEEPi was present in all 10 subjects, ranging from 0.4 cm H2O to 7.7 cm H2O. The onset of EFL was heralded by a distinct inflection point on the expiratory flow–volume curve, which probably reflected small-airway closure. Administration of salbutamol had no statistically significant effect on PEEPi, EFL (as %Vt), or respiratory mechanics. EFL (%Vt) and PEEPi were significantly higher in the supine position than in the semirecumbent position, whereas the other respiratory variables did not change. Our results suggest that in the absence of externally applied PEEP, most ARDS patients exhibit EFL associated with small-airway closure and a concomitant PEEPi.
[ <sup>18</sup> F]Fluorodeoxyglucose Single Photon Emission Computed Tomography
Authors: Gopal Srinivasan, Anastasia N. Kitsiou, Stephen L. Bacharach, Marissa L. Bartlett, Claiborne Miller-Davis, Vasken Dilsizian
Journal: Circulation (1998)

Background —New high-energy collimators for single photon emission computed tomography (SPECT) cameras have made imaging of positron-emitting tracers, such as [ 18 F]fluorodeoxyglucose ( 18 FDG), possible. We examined differences between SPECT and PET technologies and between 18 FDG and thallium tracers to determine whether 18 FDG SPECT could be adopted for assessment of myocardial viability. Methods and Results —Twenty-eight patients with chronic coronary artery disease (mean left ventricular ejection fraction [LVEF]=33±15% at rest) underwent 18 FDG SPECT, 18 FDG PET, and thallium SPECT studies. Receiver operating characteristic curves showed overall good concordance between SPECT and PET technologies and thallium and 18 FDG tracers for assessing viability regardless of the level of 18 FDG PET cutoff used (40% to 60%). However, in the subgroup of patients with LVEF≤25%, at 60% 18 FDG PET threshold value, thallium tended to underestimate myocardial viability. In a subgroup of regions with severe asynergy, there were considerably more thallium/ 18 FDG discordances in the inferior wall than elsewhere (73% versus 27%, P &lt;.001), supporting attenuation of thallium as a potential explanation for the discordant observations. When uptake of 18 FDG by SPECT and PET was compared in 137 segments exhibiting severely irreversible thallium defects (scarred by thallium), 59 (43%) were viable by 18 FDG PET, of which 52 (88%) were also viable by 18 FDG SPECT. However, of the 78 segments confirmed to be nonviable by 18 FDG PET, 57 (73%) were nonviable by 18 FDG SPECT ( P &lt;.001). Conclusions —Although 18 FDG SPECT significantly increases the sensitivity for detection of viable myocardium in tissue declared nonviable by thallium (to 88% of the sensitivity achievable by PET), it will occasionally (27% of the time) result in falsely identifying as viable tissue that has been identified as nonviable by both PET and thallium.
SAT0185 Efficacy and safety of abatacept in lupus nephritis:
Authors: R. Furie, K. Nicholls, T.T. Cheng, F. Houssiau, R. Burgos-Vargas, S.L. Chen, J. Hillson, S. Meadows-Shropshire, M. Kinaszczuk, J.T. Merrill
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> The evaluation of abatacept (ABA), a modulator of T-cell costimulation, in lupus nephritis (LN) was supported by favorable preclinical studies in murine LN. <h3>Objectives</h3> To compare the efficacy and safety of IV ABA to placebo (PBO) on a background of mycophenolate mofetil (MMF) and steroids in a 12-month Phase II/III multicenter, double-blind, study of patients (pts) with active Class III or IV LN, including exploratory, post-hoc, and subset efficacy analyses. <h3>Methods</h3> 298 pts received PBO, ABA 30 mg/kg (30/10), or ABA 10 mg/kg (10/10) in a 1:1:1 ratio on Days 1, 15, 28, 57; thereafter, all ABA pts received 10 mg/kg through Week 48. Prespecified efficacy outcome measures: a) Primary: time to complete response (CR) (CR: eGFR within 10% of preflare/screening; urine protein/creatinine ratio [UPCR] &lt;0.26 g/g; inactive urine: confirmed at 2 consecutive visits); b) CR at Week 52; c) renal improvement (RI) (RI: UPCR &lt;50% of preflare/screening; no worsening of eGFR; inactive urine); d) renal response (RR) (RR: serum creatinine ≤125% of baseline [BL]; UPCR &lt;50% of BL and &lt;3.0 g/g if nephrotic, otherwise &lt;1.0 g/g). Post-hoc efficacy endpoint: CRrev (defined post-hoc to account for renal function misclassifications): eGFR ≥90% of preflare/screening, otherwise same as CR. <h3>Results</h3> Time to confirmed CR did not differ between groups (p=0.549 and 0.422 for ABA 10/10 and 30/10 vs PBO). Efficacy at Week 52 is shown (Table). Subset analyses of 122 nephrotic pts (BL UPCR &gt;3.0 g/g) found approximately 20–30% greater reduction in mean UPCR. Safety, assessed as deaths, serious adverse events (SAEs) and serious infections, was similar across groups. AEs were generally mild, self-limited and similar in frequencies across groups, with the exception of Herpes zoster (reported in 2.0%, 11.1%, 8.1% of PBO, ABA 10/10, ABA 30/10, respectively). Post-hoc subset analyses suggested Asian race and early reduction of proteinuria (8–12 weeks) were associated with response (CRrev and RR at Week 52) in all groups. <h3>Conclusions</h3> Abatacept and PBO, administered on a background of MMF and steroids to pts with LN, exhibited similar safety profiles, time to confirmed CR, and proportion with CR and RI. Exploratory and post-hoc analyses indicated more complete (CRrev) and renal (RR) responders with abatacept compared to PBO. <h3>Disclosure of Interest</h3> R. Furie Grant/Research support from: Bristol-Myers Squibb, Consultant for: Bristol-Myers Squibb, K. Nicholls: None Declared, T. Cheng: None Declared, F. Houssiau: None Declared, R. Burgos-Vargas Grant/Research support from: Bristol-Myers Squibb, Consultant for: Bristol-Myers Squibb, S. Chen: None Declared, J. Hillson Employee of: Bristol-Myers Squibb, S. Meadows-Shropshire Employee of: Bristol-Myers Squibb, M. Kinaszczuk Employee of: Bristol-Myers Squibb, J. Merrill Consultant for: Bristol-Myers Squibb
AUDITORY HALLUCINATIONS IN "NONPSYCHOTIC" CHILDREN
Authors: Max Levin
Journal: American Journal of Psychiatry (1932)

1. Four cases are presented of boys who had true auditory hallucinations. The boys were "non-psychotic," in the sense that they showed no acute psychotic disturbances, differing in this respect from the vast majority of the cases already recorded—cases which concern children who develop unmistakably psychotic states with hallucinations, usually at puberty. Altogether 24 episodes were reported by these boys. The episodes are recorded in detail, attention being given to setting, content, etc. 2. Two of the boys showed what probably are early symptoms of a schizophrenic reaction, although at the time of this study the evidence was not conclusive. The other two boys, while maladjusted, showed nothing suggestive of schizophrenia or any other psychosis. All four boys were below the average in intelligence, two of them conspicuously so. 3. The hallucinatory episodes are studied with regard to the quality of the hallucinatory perception, the localization, the presence of accessory sensations, the content, and the apparent "functions" that are involved. 4. The hallucinations seem to have participated in the fulfillment of the following functions: (a) Defense. (b) Enhancement of self-esteem. (c) Satisfaction of instinctive cravings and of a desire for pleasure. (d) Repression of unwelcome instinctive cravings. (e) Self-punishment, in expiation of a sense of guilt. It is emphasized that while certain functions are fulfilled, these probably constitute only one link in the chain of factors which really ,causes the hallucinations to occur. 5. In one case there is evidence of mixed deafness in one ear. In another case the evidence is suggestive of the possibility of an organic auditory disturbance. 6. The significance of the findings for the general problem of projection, and their relationship to recent work on eidetics are discussed.
Abstract 5060: Identification of somatic retrotransposon insertions across cancer types using RetroSeq
Authors: Elena Helman, Mike Lawrence, Chip Stewart, Gad Getz, Matthew Meyerson
Journal: Cancer Research (2012)

Abstract Retrotransposons comprise over 40% of the human genome and represent an important class of genetic variation. Though most elements are stationary ancient relics, it has recently been shown that some 100 elements remain highly active, copying and pasting themselves throughout the genome with each generation. Retrotransposon insertions can disrupt gene function, modulate gene expression, and lead to genomic rearrangement. These events have previously been implicated in cancer, including an account of insertional mutagenesis in APC as an early event in colon cancer progression. Due to the inherent difficulty in localizing repeat elements, however, an extensive investigation of retrotransposons’ role in cancer has not yet been performed. We developed RetroSeq, a computational framework to identify novel insertions of retrotransposons from paired-end sequencing data. In simulated data, RetroSeq identifies retrotransposon insertions with 99% sensitivity and 99% specificity. We ran RetroSeq on whole-genome sequencing data from a panel of tumors (including 9 colorectal, 20 non-small cell lung, 24 prostate and 22 breast tumors) and matched normal samples to determine the extent of somatic retrotransposon activity. We find a broad range of novel retrotransposon insertion events specific to each tumor, with some insertions falling in exonic as well as intronic and intergenic regions. These events were validated experimentally and integrated with expression and methylation data to provide a global view of retrotransposon activity in these samples. In sum, using RetroSeq we are able to localize novel retrotransposon insertions in paired-end sequencing data and provide evidence for the reactivation of retrotransposons in cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5060. doi:1538-7445.AM2012-5060
Integration of “rules” and “similarity” in a framework of information compression by multiple alignment, unification, and search
Authors: J. Gerard Wolff
Journal: Behavioral and Brain Sciences (2005)

The Simplicity and Power (SP) theory (Wolff 2003a) provides support for Pothos's proposals by illustrating how the effect of “rules” and “similarity” may be achieved within an integrated model that makes no explicit provision for either concept. The theory is described here in outline with simple examples to show how rules and similarity can emerge as properties of the system in learning, reasoning, categorization, and the parsing of language.
Reovirus oncolysis as a novel purging strategy for autologous stem cell transplantation
Authors: Chandini M. Thirukkumaran, Joanne M. Luider, Douglas A. Stewart, Tina Cheng, Sasha M. Lupichuk, Michael J. Nodwell, James A. Russell, Iwona A. Auer, Donald G. Morris
Journal: Blood (2003)
Alteration and acquisition of Siglecs during <i>in vitro</i> maturation of CD34+ progenitors into human mast cells
Authors: H. Yokoi, A. Myers, K. Matsumoto, P. R. Crocker, H. Saito, B. S. Bochner
Journal: Allergy (2006)

Using human mast cells (MC) derived by culture of CD34+ peripheral blood precursors, a comprehensive study was performed of expression of 11 known Siglecs. Analysis was initially performed at the mRNA level using gene arrays. Positive results were then validated at the protein level using indirect immunofluorescence and flow cytometry, and for some Siglecs, Western blot analysis was also used. Culture‐derived MC expressed mRNA for CD22 (Siglec‐2), CD33 (Siglec‐3), Siglec‐5, Siglec‐6, Siglec‐8 and Siglec‐10. Flow cytometry confirmed surface expression of all these molecules except for CD22 and Siglec‐10, where levels were low or undetectable. However, Western blotting was able to detect MC expression of CD22 and Siglec‐10, suggesting that these proteins were mostly cytoplasmic. CD34+ precursor cells from peripheral blood constitutively expressed surface CD33, Siglec‐5 and Siglec‐10. As they matured into MC, their constitutive levels of CD33 changed little, Siglec‐5 and Siglec‐10 declined, and Siglec‐6 and Siglec‐8 appeared de novo , all in parallel with accumulation of histamine and other MC markers, such as surface expression of Fc ɛ RI α , and CD51. Phenotypic analysis of LAD‐2 MC yielded a similar pattern of Siglec expression except that CD22 expression was particularly prominent. Finally, immunohistochemistry confirmed expression of these same Siglecs by mature tryptase‐positive MC in human lung tissues. These data demonstrate an extensive and previously unappreciated pattern of Siglec expression on human MC. Whether engagement and signaling through these inhibitory Siglecs can impact MC biology will require further investigation.
Assessment of Radiofrequency Catheter Ablation of the Slow Pathway of Atrioventricular Node on the Atrial and Ventricular Functions: A Speckle Tracking Echocardiography Study
Authors: Ahmet Çağrı Aykan, Mustafa Yıldız, Can Yücel Karabay, Beytullah Çakal, Sinem Çakal, Alparslan Şahin, Mehmet Özkan
Journal: Journal of the American College of Cardiology (2013)
Diarrhea in streptococcus pneumoniae bacteremia
Authors: Ruth Andrea Seeler, Norman M. Jacobs
Journal: American Journal of Hematology (1980)

Abstract Diarrhea with fever was a significant complaint in 26 of 280 (9.3%) of non‐SS children with S. pneumoniae bacteremia and four of 30 (13%) children with sickle syndromes and S. pneumoniae bacteremia. Two additional children with sickle‐cell disease and S. pneumoniae bacteremia developed diarrhea within hours of hospital admission; four of the six died. The mortality rate among 24 additional SS patients with S. pneumoniae bacteremia without diarrhea was 12.5% (3/24). Only one of 26 non‐SS patients with diarrhea and S. penumoniae bacteremia died; she was surgically asplenic and had fulminant 9‐hour course. The seasonality of the diarrhea cases was similar to our overall experience, and the serotypes associated with the diarrhea cases were also representative of our overall experience. Although predominantly seen in infants, the oldest non‐SS patient was 12 years, and the oldest SS patient was nine years.
Long-term exposure to high glucose up-regulates VCAM-induced endothelial cell adhesiveness to PBMC
Authors: Ciro Esposito, Gianluca Fasoli, Annarita Plati, Nicoletta Bellotti, Maria Maddalena Conte, Flavia Cornacchia, Annalisa Foschi, Tiziana Mazzullo, Luca Semeraro, Antonio Dal Canton
Journal: Kidney International (2001)
End of contract for <i>Drug and Therapeutics Bulletin</i> : <i>Australian Prescriber</i> was resurrected
Authors: John S Dowden
Journal: BMJ (2006)

EDITOR—The Drug and Therapeutics Bulletin is too important to disappear.1 If there was a need for a drug bulletin in the 1960s, that need must be greater now, considering the greater choice of drugs available.

Health professionals are busy people and …
PBB fed to immature chickens: its effect on organ weights and function and on the cardiovascular system.
Authors: R K Ringer
Journal: Environmental Health Perspectives (1978)

In a series of polybrominated biphenyl (PBB) feeding trials in White Leghorn cockerel chicks, the effects of PBB on various physiological parameters and organ weights were determined. These measurements included: growth, thyroid function, ECG, cardiac output, blood pressure, hematocrit, erythropoietin levels, and spleen, bursa of Fabricius, thyroid, testes, comb, liver weights. In addition, tissues were histologically examined. PBB, in the commercial grade form of hexabromobiphenyl, was administered continuously in the diet at levels ranging from 50 to 250 ppm. Pair-feeding studies were conducted to ascertain the effects of the drug per se since preliminary trials indicated that PBB administration resulted in decreased feed intake. Chronic administration resulted in depressed body weight as a result of decreased feed intake; decreased comb, testes, spleen, and bursa weights; increased liver and thyroid weight; hydropericardium and ascites; decreased hematological values due to depressed plasma erythropietin levels; decreased heart rate, packed cell volume, hemoglobin and cardiac output; decreased voltage amplitude of the ECG and a shift in the mean electrical axis. No significant differences were found in blood pressure (mean arterial and pulse pressure), stroke volume, or respiratory rate.
ADAM9 Expression is a Significant and Independent Prognostic Marker of PSA Relapse in Prostate Cancer
Authors: Florian R. Fritzsche, Monika Jung, Angelika Tölle, Peter Wild, Arndt Hartmann, Kirsten Wassermann, Anja Rabien, Michael Lein, Manfred Dietel, Christian Pilarsky, Daniela Calvano, Robert Grützmann, Klaus Jung, Glen Kristiansen
Journal: European Urology (2007)
The Inward Bound Cemetery
Authors: Walter B. Shelley, E. Dorinda Shelley
Journal: Annals of Internal Medicine (1990)

ExcerptThe Place is Right:Underground living at its best.Once you see it, you'll be dying to get in.Open plots available—sleep under the stars.Choice corner lots for upright accommodations.Satisfaction guaranteed: St. Peter stands behind us.All units below frost line yet above the water table.Located on Sunset Boulevard (a charming dead end street).Convenient drop-off service entrance just off Shady Lane.Your stepping stone to the future and gateway to the Milky Way.The Price is Right:Buy now—be buried later.We undersell all competition.Plot ahead for dirt cheap burial.'Holesale rates. Group discounts.All...
HIGH DOSE 111IN-PENTETREOTIDE THERAPY (SOMATOTHER™) PROLONGS SURVIVAL IN CARCINOID SYNDROME.
Authors: Lowell B. Anthony, Eugene A. Woltering, Greg D. Espenan, Michele D. Cronin, Thomas J. Maloney, Kevin E. McCarthy
Journal: Clinical Nuclear Medicine (1999)

Scientific Abstracts And Posters From The 44Th Annual Meeting Of The Southwestern Chapter Of The Society Of Nuclear Medicine, And From The 12Th Northeastern Regional Scientific Meeting Of The New England And New York Chapters Of The Society Of Nuclear Medicine
Age- and Training-Dependent Development of Arrhythmogenic Right Ventricular Cardiomyopathy in Heterozygous Plakoglobin-Deficient Mice
Authors: Paulus Kirchhof, Larissa Fabritz, Melanie Zwiener, Henning Witt, Michael Schäfers, Stephan Zellerhoff, Matthias Paul, Timur Athai, Karl-Heinz Hiller, Hideo A. Baba, Günter Breithardt, Patricia Ruiz, Thomas Wichter, Bodo Levkau
Journal: Circulation (2006)

Background— Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited disorder that causes sudden death and right ventricular heart failure in the young. Clinical data suggest that competitive sports may provoke ARVC in susceptible persons. Genetically, loss-of-function mutations in desmosomal proteins (plakophilin, desmoplakin, or plakoglobin) have been associated with ARVC. To test the hypothesis that reduced desmosomal protein expression causes ARVC, we studied the cardiac effects of heterozygous plakoglobin deficiency in mice. Methods and Results— Ten-month-old heterozygous plakoglobin-deficient mice (plakoglobin +/− ) had increased right ventricular volume, reduced right ventricular function, and spontaneous ventricular ectopy (all P &lt;0.05). Left ventricular size and function were not altered. Isolated, perfused plakoglobin +/− hearts had spontaneous ventricular tachycardia of right ventricular origin and prolonged right ventricular conduction times compared with wild-type hearts. Endurance training accelerated the development of right ventricular dysfunction and arrhythmias in plakoglobin +/− mice. Histology and electron microscopy did not identify right ventricular abnormalities in affected animals. Conclusions— Heterozygous plakoglobin deficiency provokes ARVC. Manifestation of the phenotype is accelerated by endurance training. This suggests a functional role for plakoglobin and training in the development of ARVC.
Rhabdomyolysis Resulting From Interaction of Simvastatin and Clarithromycin Demonstrated by Tc-99m MDP Scintigraphy
Authors: Joseph Trieu, Louise Emmett, Chandi Perera, Krish Thanakrishnan, Hans Van Der Wall
Journal: Clinical Nuclear Medicine (2004)

Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) are well known to be able to cause a variety of muscle-related complications, the most serious of which is rhabdomyolysis. Rhabdomyolysis is a syndrome characterized by muscle pain with creatine kinase levels 10 times higher than the upper limit of normal. With the exception of pravastatin, all statins undergo extensive microsomal metabolism by cytochrome P-450 enzymes. The combination of statins with certain drugs that inhibit these enzymes increases the risk of rhabdomyolysis by inhibiting metabolism of the statin resulting in an increase in its blood concentration. The authors describe a patient who developed severe rhabdomyolysis and renal failure caused by an interaction of simvastatin and clarithromycin therapy.
Re: Andrea Minervini, Marco Carini, Robert G. Uzzo, Riccardo Campi, Marc C. Smaldone, Alexander Kutikov. Standardized Reporting of Resection Technique During Nephron-sparing Surgery: The Surface–Intermediate–Base Margin Score. Eur Urol 2014;66:803–5
Authors: Vincenzo Ficarra, Vito Palumbo, Afrovita Kungulli, Gianluca Giannarini
Journal: European Urology (2014)