tbuckley/cabot-search huggingface dataset:
Disopyramide and Bundle-Branch Block
Authors: BRUCE I. TIMINS
Journal: Annals of Internal Medicine (1982)

Letters and Corrections1 May 1982Disopyramide and Bundle-Branch BlockBRUCE I. TIMINS, M.D.BRUCE I. TIMINS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-96-5-684_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The article on disopyramide (1) is a comprehensive and stimulating statement. A case we have recently reported elsewhere (2) suggests, however, that disopyramide may not be safe for use in the presence of bundle-branch block. A 57-year-old woman with right bundle branch block and left posterior hemiblock and ventricular premature contractions subsequently developed heart block after administration of disopyramide phosphate (Norpace, Searle Laboratories, Chicago, Illinois). With a drug challenge after implantation of a permanent pacemaker, the patient developed intermittent complete heart block.On the basis of this isolated case, close monitoring of disopyramide-treated patients who have atrioventricular or intraventricular...References1. MORADYSCHEINMANDESAI FMJ. Drugs five years later: disopyramide. Ann Intern Med. 1981;96:337-43. LinkGoogle Scholar2. TIMINSGUTMANHAFT BJJ. Disopyramide-induced heart block. Chest. 1981;79:477-9. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1982Volume 96, Issue 5Page: 684-684KeywordsDrugsHeartPacemakersPhosphatesRight bundle branch block Issue Published: 1 May 1982 PDF DownloadLoading ...
Abstract 2111: Expression pattern and mechanism of tumor suppression of Rab25
Authors: Jiming Cheng, Vijayalakshmi Ayyagari, Bharat Sunkara, Sajan Koirala, Abhinav Brahmamdam, Krishna A. Rao
Journal: Cancer Research (2011)

Abstract Introduction: Our previous work has shown that the loss of Rab25 occurs in estrogen receptor (ER) and progesterone receptor (PR) negative breast cancer cell lines and human tumor samples and seems to correlate with an active ras pathway. We have examined the expression levels of rab25 in breast tissue and have investigated the mechanism by which Rab25 exerts its anti-tumorigenic effect. Loss of Rab25 cooperates with mutant Ras to promote tumorigenesis. HIF-1α levels are reduced in Rab25 expressing cells. We have assessed Rab25 binding to the HIF-1α promoter and localized Rab25 to the nucleus, suggesting a novel mechanism for Rab25's antitumor activity and a novel function for Rab25. Materials and Methods: Cell culture – Normal mammary tissue and the RAO-3 cell line was grown in DFCI-1 medium. Cells were transduced with retroviral supernatant and selected. Expression of Rab25 in transduced cells was determined by RT-PCR and western blot. qPCR analysis- Expression of HIF-1α and Rab25 were quantified using real-time PCR with fluorescence detection. Luciferase report assay – We obtained the HIF-1α promoter fragment and inserted the promoter sequence in the pGL4 luciferase vector and the Luciferase Assay was then performed. Western blot- Protein extracts from both cytosolic and nuclear fraction were tested for Rab25 expression. Immunofluorescence- Frozen mammary tissue slides were stained with luminal and basal markers as well as antibody for Rab25 to confirm localization of Rab25 in both luminal and basal mammary epithelium. Results: 1. High level expression of Rab25 was found in luminal epithelium in normal human breast tissue. Basal epithelium also expressed Rab25. 2. Tumorigenic mammary epithelial cell lines, RAO-3 and RAO-4, have lost Rab 25 expression with nearly 1/10,000 the level of Rab25 of normal mammary basal epithelium. 3. Rab25 localizes to the nucleus and reduces luciferase activity from the HIF-1α promoter. 4. Expression of Rab25 substantially reduces HIF-1α levels. Conclusions: 1. Rab25 is a complex molecule that has been described as an intracellular transport protein. 2. It is also a tumor modulator. It can regulate tumor growth and angiogenesis. 3. Rab25 expression can be detected in both luminal epithelium and basal epithelium. 4. Our data indicate novel functions for Rab25 including reduction in HIF-1α expression and localization to the nucleus. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2111. doi:10.1158/1538-7445.AM2011-2111
Neuroprotective role of PKR in a model of neurodegeneration due to mild impairment of oxidative metabolism
Authors: François Mouton-Liger, Anne-Sophie Rebillat, Sarah Gourmaud, Audrey Leguen, Claire Paquet, Laurent Pradier, Thomas Rooney, Jacques Hugon
Journal: Molecular Neurodegeneration (2013)

Abnormalities in oxidativemetabolism, inflammation,and selective neuronal death are described features of Alzheimer 's disease (AD) pathology. Brain thiamine-dependent enzymes play an important role in energy metabolism and display reduced activity in AD. Thiamine (vitamin B1) deficiency (TD) induces regionally selective neuronal death in animal and human brains.
Indium-111–labeled Girentuximab ImmunoSPECT as a Diagnostic Tool in Clear Cell Renal Cell Carcinoma
Authors: Constantijn H.J. Muselaers, Otto C. Boerman, Egbert Oosterwijk, Johannes F. Langenhuijsen, Wim J.G. Oyen, Peter F.A. Mulders
Journal: European Urology (2013)
THE EPIDERMAL COMPONENT OF PITYRIASIS LICHENOIDES
Authors: R. MARKS, M. M. BLACK
Journal: British Journal of Dermatology (1972)

Journal Article THE EPIDERMAL COMPONENT OF PITYRIASIS LICHENOIDES Get access R. MARKS, R. MARKS The Institute of Dermatology, Lisle, Street, Leicester Square. London Search for other works by this author on: Oxford Academic Google Scholar M. M. BLACK M. M. BLACK The Institute of Dermatology, Lisle, Street, Leicester Square. London Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 87, Issue 2, 1 August 1972, Pages 106–113, https://doi.org/10.1111/j.1365-2133.1972.tb16183.x Published: 01 August 1972 Article history Accepted: 04 April 1972 Published: 01 August 1972
Different Concentrations of I-123 MIBG and In-111 Pentetreotide in the Two Main Liver Lobes in Children
Authors: Hans Jacobsson, Per M. Hellström, Per Kogner, Stig A. Larsson
Journal: Clinical Nuclear Medicine (2006)

At examinations in children with I-123 metaiodobenzylguanidine or with In-111 pentetreotide using SPECT, we have observed a different distribution of the radiopharmaceuticals between the left and right main liver lobes. This phenomenon was studied in retrospect from clinical examinations.Seventeen children (mean age, 51 months; range, 11-150 months) with neuroblastoma or ganglioneuroma examined with both radiopharmaceuticals within 1 week using SPECT were assessed. There was no history of liver disease and all liver lobes showed uniform activity distribution. Simultaneous radiologic examinations were all normal with regard to the liver. No child with a pathologic liver chemistry test was included. The activity ratios between the left and right main liver lobes were calculated from transverse tomographic sections.The mean left:right lobar activity ratio for I-123 metaiodobenzylguanidine was 1.26+/-0.12 (null hypothesis=1.00; P<0.001) and for In-111 pentetreotide 0.88+/-0.06 (null hypothesis=1.00; P<0.001). There was no age-dependent distribution of the tracers. The correlation between the tracer uptake of the different liver lobes was very weak.A functional difference between the 2 main liver lobes in utero is believed to reflect differences of the vascular supply. The current findings indicate a persisting functional heterogeneity of the liver after birth not caused by perfusion differences. A relatively higher uptake of I-123 MIBG and a lower uptake of In-111 pentetreotide of the left liver lobe are normal findings.
Johns Hopkins Hospital Reports.
Authors: W. R. Hand
Journal: JAMA (1894)

Kasota, Minn., Feb. 17, 1894. <h3>To the Editor:</h3> —I see in Book Notices ofJournalof February 17, the notice of the Johns Hopkins Hospital Reports, but it does not state the name of the publishers. If published by theJournalsend it to me with bill, or kindly inform me where it is published. Yours respectfully, W. R. Hand. The book is published by the Johns Hopkins University. Please address them direct.—[Editor.]
The effects of right atrial and ventricular pacing on the auscultatory findings in patients with mitral valve prolapse.
Authors: W D Towne, S H Rahimtoola, M Z Sinno, H S Loeb, K M Rosen, R M Gunnar
Journal: Circulation (1975)

Fifteen patients with midsystolic clicks associated with mitral valve prolapse were studied in order to assess changed in ausculatatory findings produced by pacing-induced variations in cardiac rate, rhythm, and conduction. As the heart rate was increased in stepwise intervals to the maximum possible extent by right atrial pacing (RAP) in 14 patients, the interval between the Q wave and the click (Q-C) decreased in all cases (21 plus or minus msec/10 beats/min; P smaller than 0.001). In two patients, RAP at rates of and above 118 and 159 per minute, respectively, resulted in disappearance of the click. During right ventricular pacing (RVP) without evidence of atrioventricular (A-V) dissociation on the surface ECG in ten patients, the click was inaudible at all pacing rates in three instances. In all seven of the cases in which the click was audible at the lowest rate of RVP with VA conduction, Q-C was greater and C-S2 less than that in sinus rhythm. As the rate of RVP was increased, Q-C was noted to decrease (26 plus or minus 4 msec/10 beats/min) and C-S2 to increase (19 plus or minus 7 msec/10 beats/min) in all patients. In three patients in whom RVP induced atrioventricular dissociation, the click was seen only in beats closely preceded by a P wave. In ten of 11 patients the click occurred earlier in systole with a postextrasystolic or post tachycardia beat as compared to its appearance after a sinus beat when a shorter preceding diastolic filling period was present (P smaller than 0.001). In the eleventh patient a loud systolic murmur was present during a postextrasystolic cycles. It is concluded that pacing-induced rhythm disturbances can result in disappearance of a midsystolic click or can alter its timing and cause it to mimic sonic phenomena seen in other disease states. The possibility of similar changes taking place as a result of spontaneously occurring disturbances of rate, rhythm, and conduction should be recognized in order that the possible diagnosis of mitral valve prolapse not be overlooked.
Circulatory Responses to Norepinephrine After Prolonged Treatment with Chlorothiazide
Authors: JOHN W. ECKSTEIN, MICHAEL G. WENDLING, FRANCOIS M. ABBOUD
Journal: Circulation Research (1966)

Cardiovascular responses to graded intravenous infusions of norepinephrine were measured in untreated control dogs and in dogs treated for five weeks with oral chlorothiazide. Observations were made both before and after administration of a ganglionic blocking agent. In these experiments, chlorothiazide reduced the responses of the peripheral blood vessels to the vasoconstrictor effect of norepinephrine. This effect was apparent both before and after ganglionic blockade, suggesting that modification of resting neurogenic vasomotor tone did not play a major role in the reduced responsiveness. Cardiac output and heart rate were greater during norepinephrine infusion in treated dogs before hexamethonium. Output and rate became similar in both treated and untreated groups after hexamethonium. The results provide additional evidence to support the hypothesis that chlorothiazide reduces the effectiveness of cardioinhibitory reflexes.
677 TRANSFORMING GROWTH FACTOR-β/P38 MAP KINASE SIGNALING CONTRIBUTES TO SORAFENIB RESISTANCE IN HEPATOMA
Authors: Y. Matsuda, T. Wakai, Y. Shirai, M. Yano, S. Ohkoshi, Y. Aoyagi, S. Fujimaki, A. Sanpei, S. Hirano
Journal: Journal of Hepatology (2011)
NOVEL THREE DIMENSIONAL ECHOCARDIOGRAPHIC GUIDED OPTIMIZATION IMPROVES CLINICAL OUTCOME IN CARDIC RESYNCHRONIZATION THERAPY
Authors: Carolin Sonne, Lorenz Bott-Fluegel, Simon Hauck, Martin Hadamitzky, Hasema Lesevic, Gabriele Demetz, Daniel Braun, Joerg Hausleiter, Albert Schoemig, Christof Kolb, Deutsches Herzzentrum M&uuml;nchen
Journal: Journal of the American College of Cardiology (2012)
SUPRARENAL GLAND EXTRACT IN CARDIAC DYSPNOEA AND CARDIAC DROPSY
Authors: J. C. Voigt
Journal: BMJ (1912)

THE practitioner often has to deal with failure of com- pensation in cardiac cases.-Digitalis,strophanthus, con- vallaria, caffeine-all are useful in their turn; but some- times one and all may fail us.There is no doubt that
The Cancer Patient Delay in Seeking Advice
Authors: J. Aitken-Swan, R. Paterson
Journal: BMJ (1955)

ConclusionAfter thirty-five years in medical practice I have attempted (I am afraid in a very muddled way) to paint a picture of a peculiarly difficult problem in human relationships- namely, the triangular one between the patient, the doctor, and the State.A perfect solution depends upon an agreed philosophy of life, but unfortunately that does not exist.Compromise is therefore essential.Now I must have said much with which you will not agree.I may have made statements which you positively dislike.You may think that I have painted the darker corners of medical practice in too sombre colours.But I have raised questions which must be faced.True that I have given you no answers to any of them, but I venture to hope that I have helped you toward a better understanding of the problems being raised by the power of medicine which, to adapt again Mr. Dunning's famous motion in the Commons, " has increased, is increasing and is likely to increase still further.
THE RELATION OF THE SPLEEN TO BLOOD DESTRUCTION AND REGENERATION AND TO HEMOLYTIC JAUNDICE
Authors: Kingo Goto
Journal: The Journal of Experimental Medicine (1917)

1. In four animals with a bile duct-ureter anastomosis and without disturbance due to obstruction or absorption, the total quantity of bile pigment output during a day under normal conditions varied from 0.0618 to 0.0678 gm. These figures are practically identical with those of Stadelmann (9, 10) but lower than those given by Hooper and Whipple (7), who find that the average bile pigment excretion amounts to about 1 mg. per pound of body weight per 6 hours. 2. In all the experiments there is definite evidence of a decrease in bile pigment elimination after splenectomy. This is true not only of the elimination when no hemolytic agent is administered but also when excessive blood destruction is caused. Under the latter circumstances the amount of bile pigment is greatly increased but never reaches the high level of blood destruction before splenectomy. 3. These observations appear to show conclusively that the absence of the spleen influences the formation of bile pigment. To what extent the influence is mechanical, i.e., change in the course of the blood to the liver, and to what extent due to anemia, cannot be stated at present.
SURGICAL ASPECTS OF TUBERCULOSIS.
Authors: HERMANN B. GESSNER
Journal: JAMA (1906)

By the above title we understand tuberculosis as it presents itself to the surgeon, to that division of the medical body which busies itself with the knife, the brace, the plaster bandage, the rubber constrictor, in other words tuberculosis accessible to external means of therapeusis. <h3>EXTENT OF THE SURGEON'S DOMAIN.</h3> How broad is the field which we are about to survey? What promise does it hold out of opportunity for rendering services of value, for doing work satisfactory to the active and to the passive party? A brief view of some figures bearing on this matter may be of some interest. During the decennium, 1894 to 1903, we find that in the Charity Hospital of New Orleans the prevalence of the pulmonary form, commonly accepted as medical in its aspect, was 4.24 per cent. (42 in 1,000) of the total number of patients admitted for the whites, 9.001 per cent.
The Churchlands' neuron doctrine: Both cognitive and reductionist
Authors: John Sutton
Journal: Behavioral and Brain Sciences (1999)

According to Gold &amp; Stoljar, one cannot consistently be both reductionist about psychoneural relations and invoke concepts developed in the psychological sciences. I deny the utility of their distinction between biological and cognitive neuroscience, suggesting that they construe biological neuroscience too rigidly and cognitive neuroscience too liberally. Then, I reject their characterization of reductionism. Reductions need not go down past neurobiology straight to physics, and cases of partial, local reduction are not neatly distinguishable from cases of mere implementation. Modifying the argument from unification as reduction, I defend a position weaker than the radical but stronger than the trivial neuron doctrine.
A fifth of US high school students use tobacco, finds survey
Authors: M. McCarthy
Journal: BMJ (2014)

A fifth of US high school students reported having used a tobacco product in the previous 30 days, and half said that they had tried a tobacco product at least once, says a new report from the US Centers for Disease Control and Prevention.1

For the report the CDC researchers analyzed data from the 2013 National Youth Tobacco Survey to determine current tobacco use, use at least one day in the past 30 days, and use ever. The …
A NEW TYPE SIGMOIDOSCOPE
Authors: B. B. Vincent Lyon
Journal: JAMA (1922)

This is simply a new type and not a new instrument. It embraces the better points of many of the old instruments, so that we have at last a practical sigmoidoscope for use in examination and treatment. The first important feature of the instrument is the diameter of the lumen. The Tuttle and the Lynch sigmoidoscopes are seven-eighths inch in diameter, Those we found too large for routine use, as the patient is often distressed by the passage of an instrument of so great a diameter, and consequently this important examination in the routine study of our patient was often not attempted at all, or abandoned after a first unsuccessful or painful examination, especially in nervous women. Dr. Horace Soper of St. Louis told us that he was using a sigmoidoscope of smaller lumen, and on endeavoring to purchase such an instrument we found that the short Axtell was the
Resistance of enterobacteria to carbapenem antibiotics is a global crisis
Authors: J. H. Tanne
Journal: BMJ (2012)

A large family of Gram negative bacteria, the enterobacteriaceae, are developing resistance to carbapenem antibiotics, a class of β lactam antibiotics that are often antibiotics of last resort, speakers at a New York Academy of Sciences symposium have said. They called it a global crisis.

The problem was greater than that posed by the New Delhi metallo-β-lactamase-1 plasmid (NDM-1), which confers resistance to nearly all the β lactam antibiotics ( BMJ 2010;341:c5124, doi:10.1136/bmj.c5124), said the microbiologist Barry Kreiswirth of the Public Health Research Institute at the University of Medicine and Dentistry of New Jersey. “We just don’t have many treatment options: colistin, polymyxin B, tigecycline, and rifampicin,” he said.

David Perlin, executive director of the Public Health Research Institute, said that carbapenemase producing Klebsiella pneumoniae is the most common …
Monosymptomatic hypochondriacal psychosis complicated by self‐inflicted skin ulceration, skull defect and brain abscess
Authors: C‐K. WANG, J.Y‐Y. LEE
Journal: British Journal of Dermatology (1997)

Journal Article Monosymptomatic hypochondriacal psychosis complicated by self‐inflicted skin ulceration, skull defect and brain abscess Get access C‐K. WANG, C‐K. WANG Department of Dermatology, National Cheng‐Kung University Hospital, 138 Sheng‐Li Road, Tainan, Taiwan, ROC Search for other works by this author on: Oxford Academic Google Scholar J.Y‐Y. LEE J.Y‐Y. LEE Department of Dermatology, National Cheng‐Kung University Hospital, 138 Sheng‐Li Road, Tainan, Taiwan, ROC Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 137, Issue 2, 1 August 1997, Pages 299–302, https://doi.org/10.1046/j.1365-2133.1997.18261917.x Published: 01 August 1997
Assistant Director, Science: Furthering CDC Goals
Authors: Marsha F. Goldsmith
Journal: JAMA (1990)

"YOU GO OUT there and you get the job done," sums up Mary E. Guinan, MD, PhD, about her initial CDC experience as an Epidemic Intelligence Officer in 1975 working on smallpox eradication in India. Guinan is now the agency's Assistant Director for Science. In her role as overseer of the scientific effort at the CDC, she serves as the primary advisor to the director and program managers on scientific matters, which includes developing the agency's position on scientific issues that involve other agencies or that are complex or controversial. The assistant director for science serves as liaison with the National Institutes of Health and the Food and Drug Administration on all scientific issues. This may involve encouraging collaborative studies, like the ongoing tracking survey of children who received natural growth hormone and subsequently developed Creutzfeldt-Jakob disease. Guinan also oversees the CDC Office of Health and Safety. That's a demanding
Tolerability of Accelerated Chest Irradiation and Impact on Survival of Prophylactic Cranial Irradiation in Patients with Limited-stage Small Cell Lung Cancer: Review of a Single Institution's Experience
Authors: Michael Ng, Jennifer Chong, Alvin Milner, Michael MacManus, Greg Wheeler, Andrew Wirth, Michael Michael, Vinod Ganju, Joe McKendrick, David Ball
Journal: Journal of Thoracic Oncology (2007)
Differential Effects of Glycoprotein IIb/IIIa Antagonists on Platelet Microaggregate and Macroaggregate Formation and Effect of Anticoagulant on Antagonist Potency
Authors: R.F. Storey, R.G. Wilcox, S. Heptinstall
Journal: Circulation (1998)

Background —Citrated platelet-rich plasma (PRP) turbidimetry is used for assessing pharmacodynamic effects of glycoprotein (GP) IIb/IIIa antagonists in clinical trials. However, citrate can enhance the potency of at least eptifibatide (Integrilin), and turbidimetry is insensitive to microaggregate formation. We compared PRP turbidimetry, as a measure of macroaggregate formation, with single-platelet counting in both whole blood and PRP as a measure of microaggregate formation, using both citrate and hirudin anticoagulation. Methods and Results —Three GP IIb/IIIa antagonists, eptifibatide, MK-0852, and GR144053, were compared in PRP (turbidimetry) and whole blood (platelet counting with an Ultra-Flo 100 Platelet Counter), with ADP and collagen used as agonists. Compared with hirudin, citrate enhanced the potency of eptifibatide by up to 4-fold in both PRP and whole blood ( P &lt;0.0005), modestly enhanced MK-0852 potency ( P =0.001), and had no effect on GR144053. Potency measured in PRP was 2- to 3-fold greater compared with whole blood for MK-0852 and GR144053 but 3- to 4-fold greater for eptifibatide. Simultaneous turbidimetry and platelet counting performed in PRP indicated that this is because GP IIb/IIIa antagonists are more potent inhibitors of in vitro macroaggregation than microaggregation, this effect being greater for eptifibatide in hirudinized PRP compared with GR144053 ( P =0.032). Conclusions —GP IIb/IIIa antagonist potency is variably enhanced by citrate. Macroaggregation is inhibited more effectively than microaggregation, most markedly in the case of eptifibatide in hirudinized blood. These observations have implications for the interpretation and comparison of pharmacodynamic assays and possibly for the risk/benefit ratio of different agents.