Most Gastric Low-Grade B-Cell Lymphomas of Mucosa-Associated Lymphoid Tissue Persist after <i>Helicobacter pylori</i> Eradication
Authors: Graziella Pinotti, Claudio Chini, Carlo Capella
Journal: Annals of Internal Medicine (2000)

Letters16 May 2000Most Gastric Low-Grade B-Cell Lymphomas of Mucosa-Associated Lymphoid Tissue Persist after Helicobacter pylori EradicationGraziella Pinotti, MD, Claudio Chini, MD, and Carlo Capella, MDGraziella Pinotti, MDOspedale di Circolo–Fondazione; 21100 Varese, Italy (Pinotti)Ospedale di Circolo–Fondazione; 21100 Varese, Italy (Chini)Ospedale di Circolo–Fondazione; 21100 Varese, Italy (Capella)Search for more papers by this author, Claudio Chini, MDOspedale di Circolo–Fondazione; 21100 Varese, Italy (Pinotti)Ospedale di Circolo–Fondazione; 21100 Varese, Italy (Chini)Ospedale di Circolo–Fondazione; 21100 Varese, Italy (Capella)Search for more papers by this author, and Carlo Capella, MDOspedale di Circolo–Fondazione; 21100 Varese, Italy (Pinotti)Ospedale di Circolo–Fondazione; 21100 Varese, Italy (Chini)Ospedale di Circolo–Fondazione; 21100 Varese, Italy (Capella)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-10-200005160-00031 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Eradication ofHelicobacter pylori may induce remission of low-grade gastric mucosa-associated lymphoid tissue (MALT) lymphoma (1-3). Is this remission a real regression? We followed 16 patients described in a previously published series (2) who had localized primary low-grade gastric MALT lymphoma and received anti–H. pylori therapy only. Response, evaluated every 6 months, was graded according to Wotherspoon's histologic scoring system (0 to II, complete response; III, partial response; IV to V, no response) (1).Infection with H. pylori was eradicated in all patients. With a median follow-up of 61 months (range, 44 to 87 months), 3 patients (all ...References1. Wotherspoon AC, Doglioni C, Diss TC, Pan L, Moschini A, de Boni M, et al . Regression of primary low-grade B-cell gastric lymphoma of mucosa-associated lymphoid tissue type after eradication ofHelicobacter pylori . Lancet. 1993;342:575-7. CrossrefMedlineGoogle Scholar2. Roggero E, Zucca E, Pinotti G, Pascarella A, Capella C, Savio A, et al . Eradication of Helicobacter pylori in primary low-grade gastric lymphoma of mucosa-associated lymphoid tissue. Ann Intern Med. 1995;122:767-9. LinkGoogle Scholar3. Bayerdörffer E, Neubauer A, Rudolph B, Thiede C, Lehn N, Eidt S, et al . Regression or primary gastric lymphoma of mucosa-associated lymphoid tissue type after eradication of Helicobacter pylori. MALT Lymphoma Study Group. Lancet. 1995;345:1591-4. CrossrefMedlineGoogle Scholar4. Neubauer A, Thiede C, Morgner A, Alpen B, Ritter M, Neubauer B, et al . Cure of Helicobacter pylori infection and duration of remission of low-grade gastric mucosa-associated lymphoid tissue lymphoma. J Natl Cancer Inst. 1997;89:1350-5. CrossrefMedlineGoogle Scholar5. Isaacson PG. Gastric MALT lymphoma: from concept to cure. Ann Oncol. 1999;10:637-45. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Ospedale di Circolo–Fondazione; 21100 Varese, Italy (Pinotti)Ospedale di Circolo–Fondazione; 21100 Varese, Italy (Chini)Ospedale di Circolo–Fondazione; 21100 Varese, Italy (Capella) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byImpaired response of gastric MALT-lymphoma to Helicobacter pylori eradication in patients with autoimmune diseaseHelicobacter pylori infection - current treatment practiceNonspecific but prognostic Helicobacter pylori and gastric cancer association 16 May 2000Volume 132, Issue 10Page: 846KeywordsAntibioticsAutoimmune diseasesB cellsBehaviorBiopsyCellsHelicobacter pyloriLymphoid tissueLymphomaMALT lymphoma Issue Published: 16 May 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...