tbuckley/cabot-search huggingface dataset:
Impact of [<sup>18</sup>F]Fluorodeoxyglucose Positron Emission Tomography Response Evaluation in Patients With High–Tumor Burden Follicular Lymphoma Treated With Immunochemotherapy: A Prospective Study From the Groupe d'Etudes des Lymphomes de l'Adulte and GOELAMS
Authors: Jehan Dupuis, Alina Berriolo-Riedinger, Anne Julian, Pauline Brice, Christelle Tychyj-Pinel, Hervé Tilly, Nicolas Mounier, Andrea Gallamini, Pierre Feugier, Pierre Soubeyran, Philippe Colombat, Guy Laurent, Nathalie Berenger, Rene-Olivier Casasnovas, Pierre Vera, Gaetano Paone, Luc Xerri, Gilles Salles, Corinne Haioun, Michel Meignan
Journal: Journal of Clinical Oncology (2012)

Purpose [ 18 F]Fluorodeoxyglucose positron emission tomography (PET) is widely used for the staging and restaging of patients with aggressive lymphoma, but less is known about the utility of PET in patients with follicular lymphoma (FL). In a prospective study, we evaluated the prognostic value of PET performed during treatment and at the end of treatment in 121 patients with FL treated with first-line immunochemotherapy. Patients and Methods Patients with previously untreated high–tumor burden FL were treated with six cycles of R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) plus two cycles of rituximab, without rituximab maintenance. PET was performed before treatment, after four cycles of R-CHOP (interim PET), and at the end of treatment (final PET). PET scans were centrally reviewed. Results The total number of patients included was 121. Median age was 57 years. After central review, interim PET (n = 111) was negative in 76% of patients, and final PET (n = 106) was negative in 78%. With a median follow-up of 23 months, 2-year progression-free survival rates were 86% for interim PET–negative versus 61% for interim PET–positive patients (P = .0046) and 87% for final PET–negative versus 51% for final PET–positive patients (P &lt; .001), respectively. Two-year overall survival also significantly differed according to final PET results: 100% versus 88% (P = .0128). Conclusion PET performed either after four cycles of R-CHOP or at the end of therapy was strongly predictive of outcome in this prospective study. Therapeutic intervention based on PET results during or after inductive treatment should be evaluated.
Genetic epidemiology of Darier's disease: a population study in the west of Scotland
Authors: S. Tavadia, E. Mortimer, C.S. Munro
Journal: British Journal of Dermatology (2002)

Darier's disease has a world-wide distribution, but estimates of prevalence have varied. The discovery that the disease is due to mutations in ATP2A2 provides the opportunity to study the genetic epidemiology of the disease in localized populations.To survey the prevalence of Darier's disease in the west of Scotland and look for founder effects in this population.We ascertained cases of Darier's disease in the west of Scotland and used genealogy and mutational analysis to seek common ancestry.Seventy-eight current cases were identified, giving a prevalence of approximately 1 : 30 000. While 63 cases gave a history of Darier's disease in previous generations, conventional genealogy identified only two pairs of two family groups with common ancestry within the last 180 years. Eleven patients (14%; three of whom had in total four affected children) had probable de novo mutations. Causative mutations in ATP2A2 have been identified in 11 of 15 pedigrees screened for mutation, but no two share the same mutation.High estimates of prevalence are likely to be due to intensive ascertainment, rather than founder effects. Darier's disease is likely to be more common than has been recognized in other populations.
Regulation of Immune Responses in SJL and F1 Hybrid Mice by γ-Irradiated Syngeneic Lymphoma Cells23
Authors: Irene R. Katz, Fumihiko Nagase, Melvin K. Bell, Nicholas M. Ponzio, G. Jeanette Thorbecke
Journal: JNCI Journal of the National Cancer Institute (1984)

Journal Article Regulation of Immune Responses in SJL and F1 Hybrid Mice by γ-Irradiated Syngeneic Lymphoma Cells Get access Irene R. Katz, Irene R. Katz Search for other works by this author on: Oxford Academic PubMed Google Scholar Fumihiko Nagase, Fumihiko Nagase Search for other works by this author on: Oxford Academic PubMed Google Scholar Melvin K. Bell, Melvin K. Bell Search for other works by this author on: Oxford Academic PubMed Google Scholar Nicholas M. Ponzio, Nicholas M. Ponzio Search for other works by this author on: Oxford Academic PubMed Google Scholar G. Jeanette Thorbecke G. Jeanette Thorbecke Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 72, Issue 1, January 1984, Pages 125–132, https://doi.org/10.1093/jnci/72.1.125 Published: 01 January 1984 Article history Received: 25 February 1983 Accepted: 12 August 1983 Published: 01 January 1984
Renal function, cytogenetic measurements, and sexual development in adolescents in relation to environmental pollutants: a feasibility study of biomarkers
Authors: Jan A Staessen, Tim Nawrot, Elly Den Hond, Lutgarde Thijs, Robert Fagard, Karel Hoppenbrouwers, Gudrun Koppen, Vera Nelen, Greet Schoeters, Dirk Vanderschueren, Etienne Van Hecke, Luc Verschaeve, Robert Vlietinck, HA Roels
Journal: The Lancet (2001)
SU2C Phase Ib Study of Paclitaxel and MK-2206 in Advanced Solid Tumors and Metastatic Breast Cancer
Authors: Ana M. Gonzalez-Angulo, Ian Krop, Argun Akcakanat, Huiqin Chen, Shuying Liu, Yisheng Li, Kirk S. Culotta, Emily Tarco, Sarina Piha-Paul, Stacy Moulder-Thompson, Vivianne Velez-Bravo, Aysegul A. Sahin, Laurence A. Doyle, Kim-Anh Do, Eric P. Winer, Gordon B. Mills, Razelle Kurzrock, Funda Meric-Bernstam
Journal: JNCI Journal of the National Cancer Institute (2015)

There is preclinical synergism between taxanes and MK-2206. We aim to determine the maximum tolerated dose, safety, and activity of combining MK-2206 and paclitaxel in metastatic cancer.Patients received weekly doses of paclitaxel at 80mg/m2 on day 1, followed by MK-2206 orally on day 2 escalated at 90mg, 135mg, and 200mg. Treatment continued until progression, excessive toxicity, or patient request. Blood and tissue were collected for pharmacokinetic and pharmacodynamics markers. A cycle consisted of three weeks of therapy. Dose-limiting toxicity (DLT) was defined as unacceptable toxicity during the first cycle. All statistical tests were two-sided.Twenty-two patients were treated, nine in dose escalation and 13 in dose expansion. Median age was 55 years. Median number of cycles was four. Dose escalation was completed with no DLT. CTCAE Grade 3 or higher adverse events were fatigue (n = 2), rash (n = 2), hyperglycemia (n = 1), and neutropenia (n = 7). Four patients in the expansion phase required MK-2206 dose reduction. Phase II recommended dose was established as paclitaxel 80mg/m2 weekly on day 1, and MK-2206 135mg weekly on day 2. Paclitaxel systemic exposure was similar in the presence or absence of MK-2206. Plasma MK-2206 concentrations were similar to data from previous phase I monotherapy. There was a statistically significant decrease in expression of pAKT S473 (P = .01) and pAKT T308 (P = .002) after therapy. PI3K/AKT/mTOR downregulation in tumor tissues and circulating markers did not correlate with tumor response or clinical benefit. There were five objective responses, and nine patients had stable disease.MK-2206 was well tolerated with paclitaxel. Preliminary antitumor activity was documented.
1024-52 The crushing technique for bifurcation lesions: Immediate and mid-term clinical outcome
Authors: Flavio Airoldi, Goran Stankovic, Dejan Orlic, Alaide Chieffo, Carlo Briguori, Mauro Carlino, Matteo Montorfano, Ghada Mikhail, Iassen Michev, Giancarlo Vitrella, Carlo Di Mario, Antonio Colombo
Journal: Journal of the American College of Cardiology (2004)
Pyridoxine for Levodopa-Induced Dystonia
Authors: Harry Douglas Jameson
Journal: JAMA (1970)

<h3>To the Editor.—</h3> Torsion dystonia has been a distressing side effect of the treatment of Parkinson's disease with levodopa (L-DOPA).<sup>1</sup>Several authorities have indicated that pyridoxine interferes with both the desired and the undesirable effects of levodopa. The time necessary for this effect to occur is said to be several days. I have seen this happen in less than 30 minutes with persistent effect. <h3>Report of a Case.—</h3> A 51-year-old man had become so disabled in two years by rigidity, bradykinesia, and stooped posture that he was confined to a nursing home. Tremor was moderate but not a primary problem. Levodopa was begun in increasing doses up to 2 gm four times daily for three weeks. This resulted in abolition of tremor, about 25% improvement in the rigidity and bradykinesia, about 50% improvement in posture, and no undesirable effects. The patient was able to return to complete self-care in
Clinical Efficacy Of Subcutaneous and Sublingual Immunotherapy In Asthma and Rhinitis Children Sensitized To House Dust Mite
Authors: Min-Ju Kim, Eun Lee, Keun-Mi Park, Keum-Hee Hwang, Young-Ho Jung, Song-Yi Yang, Jae-Eun Lee, Hee-Kyeong Kim, Hye-yeong Lee, Jin-ho Yu, Soo-Jong Hong
Journal: Journal of Allergy and Clinical Immunology (2014)
The Influence of the Carbonic Anhydrase Inhibitor, Benzolamide (CL-11,366), on the Reabsorption of Chloride, Sodium, and Bicarbonate in the Proximal Tubule of the Rat
Authors: Robert T. Kunau
Journal: Journal of Clinical Investigation (1972)

Benzolamide (CL-11,366), a potent carbonic anhydrase inhibitor, was used to examine the influence of carbonic anhydrase inhibition on the reabsorption of chloride, sodium, and bicarbonate in the rat proximal convoluted tubule. Administration of 2 mg/kg benzolamide was associated with a decrease in the tubular fluid/plasma (TF/P) chloride ratio from 1.19±0.10 (SEM) to 1.06±0.01, and an increase in the TF/P bicarbonate ratio from 0.181±0.02 to 0.584±0.02. This dose of benzolamide significantly reduced proximal fractional reabsorption of chloride by 29.14%, of sodium by 34.3%, and of bicarbonate by 35.64%. These results indicate that benzolamide administration inhibits the reabsorption of all three electrolytes in the proximal convoluted tubule. Although 20 mg/kg benzolamide accentuated the changes in fractional reabsorption, the differences between 2 and 20 mg/kg were not statistically significant.
Inadequate smears are not always due to poor technique
Authors: A. Tree, P. Mansour
Journal: BMJ (1995)

that performance indicators as introduced by family health services authorities will be used punitively to identify deficiencies and exert con- trol.Continuous quality improvement aims not to blame but, instead, to seek the root causes of a failure in process that can be improved.3Important tenets of continuous quality improvement are that efforts for improvement are internally driven, not an external mandate; that it focuses on systems first and individuals second; that it recognises that error free care cannot be guaranteed but instead empha- sises that the quality of care can always be contin- uously improved; and that the commitment of leaders is necessary.2Quality of care should be assessed and moni- tored and efforts made to improve standards.Nevertheless, the imposition of performance indicators by family health services authorities without consultation and negotiation is unlikely to be as beneficial as a well planned quality improve- ment programme that aims to get each primary health care team continually to improve the quality of care provided.As with many things that are imposed, people will try to find ways of cheating the system and of going through the motions of monitoring and evaluation while not really believ- ing in them.Performance indicators can certainly be useful, but they should be only one of many tools used in a much wider programme that seeks to improve quality of care.It is also vital that any such project be proactive and a collaborative effort between management and all those in the front line of the provision ofhealth care.
A liposome-based nanocarrier for preferential targeting of the mononuclear phagocyte system in arthritic mice
Authors: G Courties, J Presumey, V Escriou, D Scherman, C Jorgensen, F Apparailly
Journal: Annals of the Rheumatic Diseases (2010)

Cells from the mononuclear phagocyte system (MPS) play a key role in the systemic and local progression as well as in the chronicity of rheumatoid arthritis (RA). MPS cells produce many molecules which participate in the inflammatory and catabolic events of RA pathogenesis. Thus, engineering of vectors tailored to selectively target both tissue resident and circulating MPS cells is certainly one of the most …
High expression of activation-induced cytidine deaminase (AID) and splice variants is a distinctive feature of poor-prognosis chronic lymphocytic leukemia
Authors: Helen McCarthy, William G. Wierda, Lynn L. Barron, Candy C. Cromwell, Jing Wang, Kevin R. Coombes, Roberto Rangel, Kojo S. J. Elenitoba-Johnson, Michael J. Keating, Lynne V. Abruzzo
Journal: Blood (2003)
Zwitterionic Poly(carboxybetaine)-based Cationic Liposomes for Effective Delivery of Small Interfering RNA Therapeutics without Accelerated Blood Clearance Phenomenon
Authors: Yan Li, Ruiyuan Liu, Yuanjie Shi, Zhenzhong Zhang, Xin Zhang
Journal: Theranostics (2015)

For efficient delivery of small interfering RNA (siRNA) to the target diseased site in vivo, it is important to design suitable vehicles to control the blood circulation of siRNA. It has been shown that surface modification of cationic liposome/siRNA complexes (lipoplexes) with polyethylene glycol (PEG) could enhance the circulation time of lipoplexes. However, the first injection of PEGylated lipoplexes in vivo induces accelerated blood clearance and enhances hepatic accumulation of the following injected PEGylated lipoplexes, which is known as the accelerated blood clearance (ABC) phenomenon. Herein, we developed zwitterionic poly(carboxybetaine) (PCB) modified lipoplexes for the delivery of siRNA therapeutics, which could avoid protein adsorption and enhance the stability of lipoplexes as that for PEG. Quite different from the PEGylation, the PCBylated lipoplexes could avoid ABC phenomenon, which extended the blood circulation time and enhanced the tumor accumulation of lipoplexes in vivo. After accumulation in tumor site, the PCBylation could promote the cellular uptake and endosomal/lysosomal escape of lipoplexes due to its unique chemical structure and pH-sensitive ability. With excellent tumor accumulation, cellular uptake and endosomal/lysosomal escape abilities, the PCBylated lipoplexes significantly inhibited tumor growth and induced tumor cell apoptosis.
Long-Term Results of Carotid Stenting versus Endarterectomy in High-Risk Patients
Authors: Hitinder S. Gurm, Jay S. Yadav, Pierre Fayad, Barry T. Katzen, Gregory J. Mishkel, Tanvir K. Bajwa, Gary Ansel, Neil E. Strickman, Hong Wang, Sidney A. Cohen, Joseph M. Massaro, Donald E. Cutlip
Journal: New England Journal of Medicine (2008)

We previously reported that, in a randomized trial, carotid stenting with the use of an emboli-protection device is not inferior to carotid endarterectomy for the treatment of carotid artery disease at 30 days and at 1 year. We now report the 3-year results.
Lobectomy with sleeve resection in the treatment of bronchial tumours
Authors: G. M. Rees, M. Paneth
Journal: Thorax (1970)

Forty-six patients with malignant tumours involving the orifices of the lobar bronchi were treated by lobectomy with sleeve resection of the bronchus. The results indicate that this procedure has many advantages when compared with pneumonectomy, which is the commonly practised alternative method of treatment. An immediate mortality rate following operation of 2·2% and a five-year survival rate of 35% are recorded. Simple lung function tests taken before and after surgery in a small unselected group showed that operation caused little physiological impairment.
Genesis and Expansion of Metazoan Transcription Factor Gene Classes
Authors: Claire Larroux, Graham N. Luke, Peter Koopman, Daniel S. Rokhsar, Sebastian M. Shimeld, Bernard M. Degnan
Journal: Molecular Biology and Evolution (2008)

We know little about the genomic events that led to the advent of a multicellular grade of organization in animals, one of the most dramatic transitions in evolution. Metazoan multicellularity is correlated with the evolution of embryogenesis, which presumably was underpinned by a gene regulatory network reliant on the differential activation of signaling pathways and transcription factors. Many transcription factor genes that play critical roles in bilaterian development largely appear to have evolved before the divergence of cnidarian and bilaterian lineages. In contrast, sponges seem to have a more limited suite of transcription factors, suggesting that the developmental regulatory gene repertoire changed markedly during early metazoan evolution. Using whole-genome information from the sponge Amphimedon queenslandica, a range of eumetazoans, and the choanoflagellate Monosiga brevicollis, we investigate the genesis and expansion of homeobox, Sox, T-box, and Fox transcription factor genes. Comparative analyses reveal that novel transcription factor domains (such as Paired, POU, and T-box) arose very early in metazoan evolution, prior to the separation of extant metazoan phyla but after the divergence of choanoflagellate and metazoan lineages. Phylogenetic analyses indicate that transcription factor classes then gradually expanded at the base of Metazoa before the bilaterian radiation, with each class following a different evolutionary trajectory. Based on the limited number of transcription factors in the Amphimedon genome, we infer that the genome of the metazoan last common ancestor included fewer gene members in each class than are present in extant eumetazoans. Transcription factor orthologues present in sponge, cnidarian, and bilaterian genomes may represent part of the core metazoan regulatory network underlying the origin of animal development and multicellularity.
Hunting for a pleural fluid test for mesothelioma: is soluble mesothelin the answer?
Authors: Y C G. Lee
Journal: Thorax (2007)

An estimated 150 000 patients develop a pleural effusion each year in the UK. Establishing the aetiology of pleural effusions can be challenging as they can be associated with over 50 systemic or pulmonary disorders.1 Exudative pleural fluids arise from plasma extravasation and contain proteins and cells from the systemic circulation, as well as those released locally from the pleura. This milieu of cellular products potentially holds vital clues that can unveil the underlying cause of the effusion. Decoding these clues has been a long and slow journey,2 and only in recent years have several disease-specific pleural fluid markers been incorporated into clinical practice (eg, adenosine deaminase for tuberculous pleuritis3 and brain natriuretic peptide for effusions from cardiac failure).

It is logical that diagnostic clues for mesothelioma, a primary pleural malignancy, would rest within the pleural fluid. The incidence of mesothelioma is rising significantly in the UK and other European countries. Most patients with mesothelioma present with a pleural effusion, and this diagnosis should be considered in all patients with exudative effusions. However, fluid cytology has a notoriously low diagnostic yield, as differentiating mesothelioma cells from benign (or reactive) mesothelial cells is difficult. More invasive procedures such as thoracoscopy for tissue biopsy samples are frequently required.4

Finding a diagnostic marker for mesothelioma is a challenging endeavour.5 This is made difficult by the heterogeneity of mesothelioma, which comprises various histological subtypes (eg, epithelioid, sarcomatoid, desmoplastic) with dissimilar gene expression patterns,6 phenotypes and biological features.4 No unique molecule has been shown to reliably define mesothelioma from benign mesothelium or metastatic carcinomas, even by profiling the expression of tens of thousands of genes on mesothelioma tissues using microarray technology.7

The …
SBA-Positive Fibers between the CD Ampulla, Mesenchyme, and Renal Capsule
Authors: Karl Schumacher, Raimund Strehl, Uwe de Vries, Hermann Josef Groene, Will W. Minuth
Journal: Journal of the American Society of Nephrology (2002)

During kidney development, the CD shows two peculiarities. First, the tip of the CD ampulla is always found at a specific distance from the organ capsule. Second, the CD growth occurs as a perfectly straight elongation. It is unknown whether the CD-specific growth is dependent on hormonal action or on structural elements. Histochemical experiments on neonatal rabbit kidney yielded new insight into the interface of the CD ampulla and the surrounding nephrogenic mesenchyme. Incubation of tissue sections with soybean lectin (SBA) showed the existence of fibers extending in a radial course from the ampullar tip through the mesenchyme toward the organ capsule. SBA labeling did not colocalize with collagen type I, III, IV, V, and VI, laminin, fibronectin, and tenascin. It is assumed that while the kidney increases in volume the structural fixation of the ampullar tip by the SBA-positive fibers causes CD ampullae to maintain a constant distance from the organ capsule. The connection would explain the linear extension of the CD in relation to the organ capsule. In addition, the presented data suggest that the SBA-positive fibers between ampullar tip and organ capsule create a structural microcompartmentation of the nephrogenic zone.
Pericytes and vessel maturation during tumor angiogenesis and metastasis
Authors: Ahmad Raza, Michael J. Franklin, Arkadiusz Z. Dudek
Journal: American Journal of Hematology (2010)

Abstract Despite promising results in preclinical and clinical studies, the therapeutic efficacy of antiangiogenic therapies has been restricted by a narrow focus on inhibiting the growth of endothelial cells. Other cell types in the tumor stroma are also critical to the progression of cancer, including mural cells. Mural cells are vascular support cells that range in phenotype from pericytes to vascular smooth muscle cells. Although the role of pericytes and pericyte‐like cells in the pathophysiology of cancer is still unclear, evidence indicates that aberrations in pericyte–endothelial cell signaling networks could contribute to tumor angiogenesis and metastasis. The purpose of this review is to evaluate critically recent evidence on the role of pericytes in tumor biology and discuss potential therapeutic targets for anticancer intervention. Am. J. Hematol. 85:593–598, 2010. © 2010 Wiley‐Liss, Inc.