Intestinal Lactase Deficiency in Ulcerative Colitis and Regional Ileitis
Authors: JOHN E. STRUTHERS
Journal: Annals of Internal Medicine (1965)

Article1 August 1965Intestinal Lactase Deficiency in Ulcerative Colitis and Regional IleitisJOHN E. STRUTHERS JR., M.D., JOHN W. SINGLETON, M.D., FRED KERN JR., M.D., F.A.C.P.JOHN E. STRUTHERS JR., M.D.Search for more papers by this author, JOHN W. SINGLETON, M.D.Search for more papers by this author, FRED KERN JR., M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-2-221 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMilk intolerance occurs frequently in patients with chronic ulcerative colitis (1, 2) and occasionally in patients with regional ileitis (3). In such patients the ingestion of milk causes an increase in diarrhea and abdominal discomfort, and the withdrawal of milk from the diet is associated with symptomatic improvement. Sensitivity to milk protein has been suggested as the cause of milk intolerance in some patients with chronic ulcerative colitis, supported by the finding of high titers of circulating antibodies to milk proteins (4-6). Recent evidence (3, 7), however, indicates that the concentration of antibody against cow's milk protein is not related...References1. ANDRESEN AF: Ulcerative colitis—an allergic phenomenon. Amer. J. Dig. Dis. 9: 91, 1942. CrossrefGoogle Scholar2. TRUELOVE SC: Ulcerative colitis provoked by milk. Brit. Med. J. 1: 154, 1961. CrossrefMedlineGoogle Scholar3. SEWELLCOOKECOXMAYNELL PWTEVMJ: Milk intolerance in gastrointestinal disorders. Lancet 2: 1132, 1963. CrossrefMedlineGoogle Scholar4. TAYLORTRUELOVE KBSC: Circulating antibodies to milk proteins in ulcerative colitis. Brit. Med. J. 2: 924, 1961. CrossrefMedlineGoogle Scholar5. GRAY JG: Antibodies to cow's milk in ulcerative colitis. Ibid., p. 1265. Google Scholar6. 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DAHLQVISTHAMMONDCRANEDUNPHYLITTMAN AJBRKJVA: Intestinal lactase deficiency and lactose intolerance in adults. Gastroenterology 45: 488, 1963. CrossrefMedlineGoogle Scholar26. AURICCHIORUBINSLANDOLTSEMENZAPRADER SAMGA: Isolated lactase deficiency in the adult. Lancet 2: 324, 1963. CrossrefMedlineGoogle Scholar27. KLOTZ AP: Intestinal lactase deficiency and diarrhea in adults. Amer. J. Dig. Dis. 9: 345, 1964. CrossrefMedlineGoogle Scholar28. JEEJEEBHOYDESAIVERGHESE KNHGRV: Milk intolerance in tropical malabsorption syndrome, role of lactose malabsorption. Lancet 2: 666, 1964. CrossrefMedlineGoogle Scholar29. PLOTKINISSELBACHER GRKJ: Secondary disaccharidase deficiency in adult celiac disease (nontropical sprue) and other malabsorption states. New Eng. J. Med. 271: 1033, 1964. CrossrefMedlineGoogle Scholar30. MILLERCRANE DRK: The digestive function of the epithelium of the small intestine. II. Location of disaccharide hydrolysis in the isolated brush border portion of intestinal epithelial cells. Biochim. Biophys. Acta 52: 293, 1961. CrossrefMedlineGoogle Scholar31. SANTINIAVILESSHEEHY RJTW: Sucrase activity in the intestinal mucosa of patients with sprue and normal subjects. Amer. J. Dig. Dis. 5: 1059, 1960. CrossrefMedlineGoogle Scholar32. BAYLESSWALTERBARBER TMWR: Disaccharidase deficiencies in tropical sprue. Clin. Res. 12: 445, 1964. Google Scholar33. Unpublished data. Google Scholar34. WEIJERSVAN DE KAMERDICKEIJSSELING HAJHWKJ: Diarrhea caused by deficiency of sugar-splitting enzymes. I. Acta Paediat. (Stockholm) 50: 55, 1961. CrossrefMedlineGoogle Scholar35. WEIJERSVAN DE KAMER HAJH Diarrhea caused by deficiency of sugar-splitting enzymes. II. Acta Paediat. (Stockholm) 51: 371, 1962. CrossrefGoogle Scholar36. SUNSHINEKRETCHMER PN: Studies of small intestine during development. III. Infantile diarrhea associated with intolerance to disaccharides. Pediatrics 34: 38, 1964. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOHN E. STRUTHERSJR., M.D.; JOHN W. SINGLETON, M.D.; FRED KERNJR., M.D., F.A.C.P.Affiliations: Denver, ColoradoFrom the Division of Gastroenterology, Department of Medicine, University of Colorado School of Medicine, Denver, Colo.This study was supported by research grant AM 07256 GM, and training grant AM 5122-07, National Institutes of Health, U. S. Public Health Service, Bethesda, Md., and the National Institutes of Health Clinical Medical Facility of the University of Colorado School of Medicine, Denver Colo.Dr. Singleton is the recipient of a National Institutes of Health Special Fellowship.This study was presented in part at the Twenty-second Annual Meeting of the Midwestern Section of the American Federation for Clinical Research, November 5, 1964, Chicago, Ill.Requests for reprints should be addressed to Fred Kern, Jr., M.D., Head, Division of Gastroenterology, University of Colorado School of Medicine, 4200 East Ninth Avenue, Denver, Colo. 80220. 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