tbuckley/cabot-search huggingface dataset:
Public Preferences About Secondary Uses of Electronic Health Information
Authors: David Grande, Nandita Mitra, Anand Shah, Fei Wan, David A. Asch
Journal: JAMA Internal Medicine (2013)

As health information technology grows, secondary uses of personal health information offer promise in advancing research, public health, and health care. Public perceptions about sharing personal health data are important for establishing and evaluating ethical and regulatory structures to oversee the use of these data.To measure patient preferences about sharing their electronic health information for secondary purposes (other than their own health care).In this conjoint analysis study, we surveyed 3336 adults (568 Hispanic, 500 non-Hispanic African American, and 2268 non-Hispanic white); participants were randomized to 6 of 18 scenarios describing secondary uses of electronic health information, constructed with 3 attributes: uses (research, quality improvement, or commercial marketing), users (university hospitals, commercial enterprises, or public health departments), and data sensitivity (whether it included genetic information about their own cancer risk). This design enabled participants to reveal their preferences for secondary uses of their personal health information.Participants responded to each conjoint scenario by rating their willingness to share their electronic personal health information on a 1 to 10 scale (1 represents low willingness; 10, high willingness). Conjoint analysis yields importance weights reflecting the contribution of a dimension (use, user, or sensitivity) to willingness to share personal health information.The use of data was a more important factor in the conjoint analysis (importance weight, 64.3%) than the user (importance weight, 32.6%) and data sensitivity (importance weight, 3.1%). In unadjusted linear regression models, marketing uses (β = -1.55), quality improvement uses (β = -0.51), drug company users (β = -0.80), and public health department users (β = -0.52) were associated with less willingness to share health information than research uses and university hospital users (all P < .001). Hispanics and African Americans differentiated less than whites between uses.Participants cared most about the specific purpose for using their health information, although differences were smaller among racial and ethnic minorities. The user of the information was of secondary importance, and the sensitivity was not a significant factor. These preferences should be considered in policies governing secondary uses of health information.
Ferric Hydroxide Particles Labeled With Indium In 113m for Lung Scanning
Authors: David A. Goodwin
Journal: JAMA (1968)

Regional pulmonary arterial blood flow may be effectively measured by the distribution of radioactive particles in the lung following an intravenous injection. The original method required use of iodinated I 131 serum albumin, aggregated (MAA 131 [Human]), which limited the total amount of injected radioactivity to a maximum of about 300μc. To increase the photon output while decreasing the radiation-absorbed dose, we labeled iron hydroxide aggregates with the short-lived nuclide, indium In 113m. This isotope may be obtained economically in the carrier-free state from a tin Sn 113-indium In 113m generator in the clinical radioisotope laboratory. The preparation of the particles takes 15 minutes, and they may be autoclaved prior to injection. These aggregates have suitable physical and biological characteristics for lung scanning, and permit better images in a shorter period of time than iodinated I 131 serum albumin, aggregated.
Acute Pancreatitis as a Psychophysiologic Response: A Case Study
Authors: LARRY E. TRIPP, DAVID P. AGLE
Journal: American Journal of Psychiatry (1968)

A 30-year-old man experienced episodes of acute recurrent pancreatitis; documented episodes were accompanied by a specific psychologic conflict and its specific affects of guilt, anger, and feelings of rejection. The author concludes that the pancreatitis occurred as a psychophysiologic response and as part of a total psychiatric disorder.
Drugs for asthma: mast-cell stabilisers
Authors: A M Edwards, T S C Orr
Journal: BMJ (1981)

phosphodiesterase-inhibiting properties,' and more recently functional SRS-A antagonism.2The clinical relevance of these properties is the subject of further investigation.Ketotifen was shown early in its development to inhibit antigen-induced bronchospasm in man when given orally.3This encouraged further clinical development, leading to other controlled trials, now reported4-9 (also by Carrasco et al at 11th International Congress of Allergology, Jerusalem, 1979), as well as the one cited'' in the review.The majority of trials, particularly the long-term studies, demonstrate efficacy for ketotifen in com- parison with placebo or other agents.4-10
Abstract 5141: Inhibition of HDAC1 leads to subtype switching in the SW13 adrenal adenocarcinoma line
Authors: Jessica M. Lam, Juliane Daggett, Kathryn J. Leyva, Elizabeth E. Hull
Journal: Cancer Research (2014)

Abstract HDAC (histone deacetylase) enzymes are highly expressed in cancer cells and HDAC inhibitors have shown promise in clinical trials for certain patients in multiple types of cancer. In this context, the ability of the SW13 human adrenal adenocarcinoma line to switch between two well-established subtypes in response to HDAC inhibition is of interest. However, the previously characterized inhibitor (trichostatin A) is a toxic, broad-spectrum inhibitor affecting both class I and class II HDACs which have roles in the nucleus and cytosol, respectively. Multiple HDAC inhibitors are screened for their ability induce switching between the SW13 subtypes to identify which HDAC enzyme is necessary for controlling SW13 subtype switching. Results suggest that inhibition of class I HDAC1 increases the rate of conversion between SW13- to SW13+ cells. The effect of HDAC1 inhibition may be enhanced by HDAC3 inhibition as MS-275, an inhibitor specific for HDAC1 but with some specificity for HDAC3, is most effective, particularly when compared to the efficacy of depudecin, an HDAC1 specific inhibitor. After conversion to SW13+, there is increased acetylation on histone H3 but not histone H4 when compared to levels in SW13-, suggesting that the role of acetylation on the H3 tail plays an essential role in the subtype switch. SW13- cells do not express Brg1 or Brm, the mutually exclusive ATPase subunits of the SWI/SNF complex, and do not have an active SWI/SNF complex. Altered activity of this complex and the increased histone H3 acetylation may contribute to the extensive changes in gene expression observed between SW13+ and SW13- subtypes. Citation Format: Jessica M. Lam, Juliane Daggett, Kathryn J. Leyva, Elizabeth E. Hull. Inhibition of HDAC1 leads to subtype switching in the SW13 adrenal adenocarcinoma line. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 5141. doi:10.1158/1538-7445.AM2014-5141
Bone Metastasis Detected by FDG PET in a Patient With Breast Cancer and Fibrous Dysplasia
Authors: Toshirou Shigesawa, Yoshifumi Sugawara, Isao Shinohara, Takashi Fujii, Teruhito Mochizuki, Ichiro Morishige
Journal: Clinical Nuclear Medicine (2005)

Bone scintigraphy is sensitive for detecting bone metastases in patients with malignancies. However, it is often difficult to differentiate bone metastases from other nonmalignant lesions. We encountered a patient with a history of breast cancer who showed substantial elevation of tumor markers 4 years after surgery. Although there were no subjective symptoms and the bone scan showed multiple hot spots, which were similar to previous scans and which had been diagnosed as fibrous dysplasia on radiographs, a whole-body FDG PET scan showed a solitary area of intense uptake at the site of one of the hot spots in the bone scan. A solitary bone metastasis was confirmed by MRI and the patient then received radiation therapy and the elevated tumor markers of CEA and CA 15-3 were normalized after the therapy.
Glucose Abnormalities in Patients With Hepatitis C Virus Infection: Epidemiology and Pathogenesis
Authors: Umberto Vespasiani Gentilucci, Antonio Picardi, Paolo Pozzilli
Journal: Diabetes Care (2006)

We read with great interest the review article by Lecube et al. (1) on the pathogenic factors specifically linking hepatitis C virus (HCV) infection and glucose abnormalities. After analyzing the different mechanisms by which HCV is thought to contribute to the development of type 2 diabetes, Lecube et al. focus their attention on the role of proinflammatory …
Potential biases were not taken into account in study of waiting times
Authors: N. Black
Journal: BMJ (1998)

We conclude, firstly, that the management of women who present to accident and emergency departments requiring emergency contraception is in disarray and that experts should suggest a common approach.This would ensure consistent management throughout the United Kingdom based on published data reflecting the safety of such drug treatment.Secondly, any protocol should be realistic and should spare women the inconvenience and often the embarrassment of seeking such emergency care; it should also include recommendations concerning follow up.
Tumor-Surrogate Blood Vessel Subtypes Exhibit Differential Susceptibility to Anti-VEGF Therapy
Authors: Basel Sitohy, Janice A. Nagy, Shou-Ching Shih Jaminet, Harold F. Dvorak
Journal: Cancer Research (2011)

Antivascular therapy directed against VEGF or its receptors (VEGFR) has been successful when administered at early stages of tumor vessel growth but is less effective when administered later. Tumor blood vessels are heterogeneous, so vessel subpopulations may differ in their requirements for tumor cell-secreted VEGF and in their susceptibility to anti-VEGF/VEGFR therapy. Human cancers contain several distinct blood vessel types, including mother vessels (MV), glomeruloid microvascular proliferations (GMP), vascular malformations (VM), feeding arteries (FA), and draining veins (DV), all of which can be generated in mice in the absence of tumor cells using expression vectors for VEGF-A(164). In this study, we investigated the sensitivity of each of these vessel types to anti-VEGF therapy with Aflibercept (VEGF Trap), a potent inhibitor of VEGF-A(164). Administering VEGF Trap treatment before or shortly after injection of a recombinant VEGF-A(164)-expressing adenovirus could prevent or regress tumor-free neovasculature, but it was progressively less effective if initiated at later times. Early-forming MVs and GMPs in which the lining endothelial cells expressed high levels of VEGFR-2 were highly susceptible to blockade by VEGF Trap. In contrast, late-forming VMs, FAs, and DVs that expressed low levels of VEGFR-2 were largely resistant. Together, our findings define the susceptibility of different blood vessel subtypes to anti-VEGF therapy, offering a possible explanation for the limited effectiveness of anti-VEGF-A/VEGFR treatment of human cancers, which are typically present for months to years before discovery and are largely populated by late-forming blood vessels.
The orphan nuclear receptor SHP acts as a negative regulator in inflammatory signaling triggered by Toll-like receptors
Authors: Jae-Min Yuk, Dong-Min Shin, Hye-Mi Lee, Jwa-Jin Kim, Sun-Woong Kim, Hyo Sun Jin, Chul-Su Yang, Kyeong Ah Park, Dipanjan Chanda, Don-Kyu Kim, Song Mei Huang, Sang Ki Lee, Chul-Ho Lee, Jin-Man Kim, Chang-Hwa Song, Soo Young Lee, Gang Min Hur, David D Moore, Hueng-Sik Choi, Eun-Kyeong Jo
Journal: Nature Immunology (2011)
Central venous pressure and impaired renal function in patients with acute heart failure
Authors: Heiko Uthoff, Tobias Breidthardt, Theresia Klima, Markus Aschwanden, Nisha Arenja, Thenral Socrates, Corinna Heinisch, Markus Noveanu, Barbara Frischknecht, Ulrich Baumann, Kurt A. Jaeger, Christian Mueller
Journal: European Journal of Heart Failure (2010)
Correction: Summary for Patients on Genes for Hemochromatosis
Authors: Victor Herbert
Journal: Annals of Internal Medicine (2001)

Letters17 April 2001Correction: Summary for Patients on Genes for HemochromatosisVictor Herbert, MD, JD, FRSMVictor Herbert, MD, JD, FRSMMount Sinai–New York University Health System; Bronx Veterans Affairs Medical Center (Herbert)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-134-8-200104170-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The title of the “Summary for Patients” (1) for Beutler and colleagues' paper (2) should read, “The Frequency of Measurable Genes for Hemochromatosis in Patients attending a Health Appraisal Clinic.” About 30% of black persons are heterozygous for hemochromatosis, and about 1% are homozygous (3), but the responsible gene has not yet been isolated (3). According to Table 1 of Beutler and colleagues' article (2), no black participants had genotype C282Y/C282Y, H63D/S65C, or S65C/S65C (38, 42, and 2 white patients, respectively, had these genotypes); only 1 black participant had genotype C282Y/H63D, and only 2 had genotype H63D/H63D (compared with 150 ...References1. The frequency of genes for hemochromatosis in patients attending a health appraisal clinic. Summary for Patients. Ann Intern Med. 2000; 133:I28. Google Scholar2. Beutler E, Felitti V, Gelbart T, Ho N. The effect of HFE genotypes on measurements of iron overload in patients attending a health appraisal clinic. Ann Intern Med. 2000;133:329-37. [PMID: 00010979877] LinkGoogle Scholar3. Herbert V, Shaw S, Jayatilleke E. Vitamin C-driven free radical generation from iron. J Nutr. 1996;126 Suppl 4 1213S-20S. [PMID: 0008642459] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Victor Herbert, MD, JD, FRSMAffiliations: Mount Sinai–New York University Health System; Bronx Veterans Affairs Medical Center (Herbert) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Frequency of Genes for Hemochromatosis in Patients Attending a Health Appraisal Clinic The Effect of HFE Genotypes on Measurements of Iron Overload in Patients Attending a Health Appraisal Clinic Ernest Beutler , Vincent Felitti , Terri Gelbart , and Ngoc Ho Metrics 17 April 2001Volume 134, Issue 8Page: 715KeywordsHemochromatosis ePublished: 17 April 2001 Issue Published: 17 April 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Medical aspects of unemployment
Authors: D R Hannay
Journal: BMJ (1982)

Finally, we, like all those who work with PGI2, are well aware of the weaknesses of plasma 6-keto-PGF50 measurement as an index of PGI, generation.At the moment, however, no other method has been shown to be clearly superior to 6-keto-PGF1,, measurement in the study of PGI2 production in vivo.Many recent papers of Dr Webster and his colleagues on PGI2, as measured by plasma 6-keto- PGF, a levels, tempt us to believe that he thinks in the same way.
Distance burning
Authors: Arlin B. Rogers
Journal: Gut Microbes (2011)

Gut microbes play a major role in carcinogenesis of the gastrointestinal tract. We and others have shown in mouse models that colonic bacteria also influence the development of extraintestinal cancers including hepatocellular and mammary carcinomas. Microbes such as Helicobacter hepaticus invoke a proinflammatory microenvironment in the lower bowel that may extend to distant organs, often in the absence of histologically evident inflammation. Innate immunity plays a crucial role in the promotion of liver cancer and other systemic diseases by gut microbes. Additional mechanisms include type 1 adaptive immunity, altered metabolism, and oxidative stress. Emerging links between host genetics, gut microbes, inflammatory bowel disease and colorectal cancer also may prove useful for the correlation of specific bacterial populations with extraintestinal neoplasms. Interruption of deleterious host-microbe networks through judicious use of antibiotics and targeted molecular therapies may help reduce the incidence of liver, breast, and other human cancers.
Case of Supernumerary Mamma.
Authors: L. G. Hardman
Journal: JAMA (1891)

<h3>To the Editor:</h3> —The subject of this article is one of some interest; and especially so in this particular case, on account of the size, and as well as the fact, that this mamma, or milk tumor, did not develop until the fifth gestation; and there was no sign of it before that time, so the patient states. We find quite a number of cases of supernumerary mammæ on record, but none with a history like this so far as I know. Bruce has examined 4,000 persons and finds the deformity to be 1.54 per cent., and he says the axillary prolongations are not infrequent and may be mistaken for lymphatic glands; also states the left side is the most common locality of these deformities. Evy Williams, col., age 39. Married; had six children. Health good. Three years ago, she was delivered of a child and at that time noticed
Capillary and arteriolar pericytes attract innate leukocytes exiting through venules and 'instruct' them with pattern-recognition and motility programs
Authors: Konstantin Stark, Annekathrin Eckart, Selgai Haidari, Anca Tirniceriu, Michael Lorenz, Marie-Luise von Brühl, Florian Gärtner, Alexander Georg Khandoga, Kyle R Legate, Robert Pless, Ingrid Hepper, Kirsten Lauber, Barbara Walzog, Steffen Massberg
Journal: Nature Immunology (2012)
The Legal Systems in the United States
Authors: Angela Roddey Holder
Journal: JAMA (1974)

THE purpose of any legal system is to provide a framework within which members of society may co-exist as peaceably as possible. Further, law is used to enforce the minimum value system that the government considers necessary for group order, and to establish the freedoms, if any, that the political philosophy prevailing in the nation guarantees to the inhabitants. While the world's legal systems are widely different results of divergent philosophies, the purpose of the legal systems is usually quite similar. Legal systems tend to adopt a rather negative view of human behavior. They restrict undesirable, but do not usually reward desirable and ethical behavior. If a citizen of the United States makes fraudulent statements on his income tax returns, he may well go to prison. If a surgeon leaves a hemostat in a patient's abdomen and the patient chooses to sue, the surgeon will probably be required to pay
A 3 Years Old Female With SCID T(-) B(-) Nk(+) Treated With Halogenic Bone Marrow Transplantation. Case Report
Authors: H. Del Olmo Tellez, G. Treviño Garza, N. Ramirez, C. Ramos Becerril, F. Rivas Larrauri
Journal: Journal of Allergy and Clinical Immunology (2007)
The Period of Incubation in Tetanus.
Authors: Albert Woldert
Journal: JAMA (1904)

Tyler, Texas, July 29, 1904. <h3>To the Editor:</h3> —In report of my case of tetanus inThe Journal, July 23, 1904, kindly make the following corrections: The patient was injured Saturday, Sept. 1, 1894, at about 7:30 p. m. Amputation at thigh was done Wednesday, Sept. 5, 1894, at 6:15 p. m. Tetanus suddenly developed at 5 a. m. on the following morning, Thursday, and he died from tetanus at 3:15 p. m. on this day, which was five days from date of injury.
T-Cell-Mediated Suppression of Hematopoiesis
Authors: Kenneth F. Mangan
Journal: New England Journal of Medicine (1985)

Eight years ago, Hoffman and co-workers reported in the Journal that peripheral-blood lymphocytes from patients with aplastic anemia could suppress the growth of erythroid colonies from normal marrow.1 Concurrently, it was shown that removal of lymphocytes from aplastic marrow by treatment with antithymocyte globulin and complement or by gravity sedimentation partially restored the growth of granulocyte progenitors.2 These studies suggested that some cases of marrow failure were due to inhibition of marrow progenitor-cell growth by "autoreactive suppressor" T lymphocytes. However, it was also suggested that the observed inhibitory effects of lymphocytes from patients with aplastic anemia were due to allosensitization . . .
Health insurance company offers genetic screening to its clients
Authors: Annette Tuffs
Journal: BMJ (2004)

A German health insurance company has offered all of its customers a test for a genetic disorder so that they can receive early treatment if they are affected. Four thousand customers took up the offer, and 67 were told that they were at high risk of the disease.

In cooperation with the Hanover Medical School, the Kaufmannische Krankenkasse (KKH), a health insurance company with about two million customers, has offered all of its clients a test for the hereditary disease haemochromatosis, a disorder in which the body stores too much iron. The results were given exclusively to the people tested and not divulged to the company.

Haemochromatosis is an autosomal recessive disorder, …
The spiral enteroscopy training initiative: results of a prospective study evaluating the Discovery SB overtube device during small bowel enteroscopy (with video)
Authors: J. Buscaglia, K. Dunbar, P. Okolo, J. Judah, P. Akerman, D. Cantero, P. Draganov
Journal: Endoscopy (2009)

See also: Commentaire de travail de J. M. Buscaglia et al., pp. 194Endoscopy 2009; 41(03): 387-388DOI: 10.1055/s-0032-1306672
Antitubercular potential of plants: A brief account of some important molecules
Authors: Arvind S. Negi, Jonnala K. Kumar, Suaib Luqman, Dharmendra Saikia, Suman P.S. Khanuja
Journal: Medicinal Research Reviews (2009)

Abstract Mycobacterium tuberculosis is the most lethal pathogen causing tuberculosis in human. After the discovery of antitubercular drugs pyrazinamide, rifampicin, isoniazid, streptomycin, and ethambutol (PRISE), the disease was controlled for a limited period. However, over the course of their usage, the pathogen acquired resistance and evolved into multi‐drug resistant, single‐drug resistant, and extensive drug resistant forms. A good number of plant secondary metabolites are reported to have antitubercular activity comparable to the existing antitubercular drugs or sometimes even better in potency. A well‐defined strategy is required to exploit these phytomolecules as antitubercular drugs. This review gives concise up‐to‐date information regarding the chemistry and pharmacology of plant‐based leads and some insight into their structure–activity relationship. © 2009 Wiley Periodicals, Inc. Med Res Rev, 30, No. 4, 603–645, 2010