tbuckley/cabot-search huggingface dataset:
The structural basis of germline-encoded VH3 immunoglobulin binding to staphylococcal protein A.
Authors: J L Hillson, N S Karr, I R Oppliger, M Mannik, E H Sasso
Journal: The Journal of Experimental Medicine (1993)

The ability of human VH3 immunoglobulins (Ig) to bind to staphylococcal protein A (SPA) via their Fab region is analogous to the binding of bacterial superantigens to T cell receptors. The present report establishes the structural basis for the interaction of SPA and VH3 Ig. We have studied a panel of 27 human monoclonal IgM that were derived from fetal B lymphocytes. As such, these IgM were expected to be encoded by unmutated germline genes. Binding to SPA in ELISA occurred with 15 of 15 VH3 IgM, but none of 12 IgM from the VH1, VH4, VH5, or VH6 families. The VH sequences of the 27 IgM were derived from 20 distinct VH elements, including 11 from the VH3 family. Use of D, JH, and CL genes was similar among VH3 and non-VH3 IgM. A comparison of the corresponding VH protein sequences, and those of previously studied IgM, identified a probable site for SPA binding that includes VH3 residues in framework region 3 (FR3), and perhaps FR1 and 3' complementary determining region 2. The results thus demonstrate that among human IgM, specificity for SPA is encoded by at least 11 different VH3 germline genes. Furthermore, like the T cell superantigens, SPA likely binds to residues in the VH framework region, outside the classical antigen-binding site of the hypervariable loops.
Prevention of Recurrent Staphylococcal Skin Infections With Low-Dose Oral Clindamycin Therapy
Authors: Mark S. Klempner
Journal: JAMA (1988)

We conducted a double-blind, controlled trial of low-dose (150 mg/d) oral clindamycin hydrochloride vs placebo to prevent recurrent staphylococcal skin infections. Twenty-two patients (11 in both the placebo and clindamycin treatment groups) completed the trial and were assessable. The two groups did not differ as to age, sex, race, or the number of recurrent abscesses preceding the trial. In pretrial evaluations, no patient had hypogammaglobulinemia or abnormal neutrophil function. Sixty-four percent (7/11) of the placebo-treated patients had a recurrent abscess within three months of enrollment whereas 82% (9/11) of the patients treated with clindamycin were free of any infection during the three-month treatment period. Of the nine patients who responded to clindamycin treatment, six did not have a recurrent infection for at least nine months after discontinuing antibiotic therapy. All patients tolerated the regimen without side effects. We conclude that a three-month course of low-dose oral clindamycin is an effective, convenient, well-tolerated, and often durable approach to prevention of recurrent staphylococcal skin infections.
Environmental correlates of impaired lung function in non-smokers with severe alpha 1-antitrypsin deficiency (PiZZ)
Authors: E. Piitulainen, G. Tornling, S. Eriksson
Journal: Thorax (1998)

Active smoking is the most important risk factor for pulmonary emphysema in subjects with severe alpha 1-antitrypsin (AAT) deficiency. The aim of this study was to analyse the effects of environmental risk factors other than active smoking on lung function and on respiratory symptoms in non-smoking PiZZ individuals.Lifetime exposure to passive smoking, domiciliary use of a kerosene (paraffin) heater or gas cooker, and all occupations since leaving school were reported by 205 non-smoking PiZZ individuals (95 men and 110 women) included in the Swedish AAT deficiency register. Lung function test results and histories of respiratory symptoms (chronic bronchitis, recurrent wheezing, and exertional dyspnoea) were elicited from the AAT register records.After adjustment for age, agricultural employment and domiciliary kerosene heater usage, but not gas cooker usage or passive smoking, were both associated with significantly decreased lung function. Multiple linear regression analysis showed age, sex, kerosene heater usage, and agricultural employment to be independent determinants of lung function impairment. Age and passive smoking for 10 years or more, both at home and at the work place, were associated with the presence of chronic bronchitis. Age and agricultural employment for > or = 10 years were associated with recurrent wheezing and exertional dyspnoea.Domiciliary kerosene heater usage and an agricultural occupation therefore appear to be environmental factors associated with decreased lung function in non-smoking PiZZ individuals, and passive smoking is associated with an increased frequency of chronic bronchitis, but not with impaired lung function.
Upgrading V.D. Departments
Authors: J. R. Seale
Journal: BMJ (1970)

ing studies, as yet unpublished, have shown no further fall in titre.These data suggest that vaccine induced immunity may not differ from the life-long immunity thought to follow natural rubella.It is hard to justify delay in the use of an effective prophylactic, awaiting long term evidence of perhaps 20 years, when undoubted benefit can be derived from its use now.By analogy with the experience of polio vaccines, a similar situation existed regarding the duration of immunity, but this did not deter those involved from initiating early vaccination programmes.A national programme of rubella vaccination now would undoubtedly reduce the pool of infec- tion and may well prevent many pregnant women from contracting rubella and bearing abnormal children.-Iam, etc.,
Alpha-defensins secreted by dysplastic granulocytes inhibit the differentiation of monocytes in chronic myelomonocytic leukemia
Authors: Nathalie Droin, Arnaud Jacquel, Jean-Baptiste Hendra, Cindy Racoeur, Caroline Truntzer, Delphine Pecqueur, Naïma Benikhlef, Marion Ciudad, Leslie Guery, Valérie Jooste, Erick Dufour, Pierre Fenaux, Bruno Quesnel, Olivier Kosmider, Michaëla Fontenay, Patrick Ducoroy, Eric Solary
Journal: Blood (2009)
Inhaled Corticosteroids in Patients With Stable Chronic Obstructive Pulmonary Disease
Authors: M. Bradley Drummond, Elliott C. Dasenbrook, Marshall W. Pitz, David J. Murphy, Eddy Fan
Journal: JAMA (2008)

Context-Recent studies of inhaled corticosteroid (ICS) therapy for managing stable chronic obstructive pulmonary disease (COPD) have yielded conflicting results regarding survival and risk of adverse events.Objective-To systematically review and quantitatively synthesize the effects of ICS therapy on mortality and adverse events in patients with stable COPD.
Sociodemographic and morbidity indicators of need in relation to the use of community health services: observational study
Authors: K. Buckingham, P. R Freeman
Journal: BMJ (1997)

<h3>Abstract</h3> <b>Objective:</b> To examine whether the sociodemographic and morbidity characteristics of populations influence their use of the following community health services: district nursing, health visiting, chiropody, community maternity, community mental illness, and the professions allied to medicine. <b>Design:</b> Observational study. <b>Setting:</b> Nationally representative sample of provider trusts in England. <b>Main outcome measures:</b> Activity levels for each service calculated for enumeration districts within the catchment areas of the sample of trusts and standardised to allow for differences in age structure. Regression analysis to determine whether the standardised activity rates for each service could be predicted by a range of socio-demographic and morbidity proxies. <b>Results:</b> Morbidity or deprivation, or both, seemed to influence the use of services in each of the care programmes examined. <b>Conclusions:</b> The allocation of funds for community health services should allow for differences in the health and socio-demographic characteristics of health authorities. <h3>Key messages</h3> Previous work to determine an appropriate target allocation of funds for health authorities has concentrated on inpatient services The portion of health expenditure estimated to be necessary for community health services has been given a zero weighting by the Department of Health This decision has attracted considerable criticism This study shows that deprivation and other demographic characteristics influence the use of community health services These findings have been used to help inform the target allocation of funds to health authorities
Quantitation of IL-2Rp75 (CD122) expression on mononuclear cells in rheumatic disease.
Authors: P Creamer, N D Hall
Journal: Annals of the Rheumatic Diseases (1996)

OBJECTIVE: To compare expression of the p75 chain of the interleukin-2 receptor (IL-2Rp75, CD122) on peripheral and synovial mononuclear cells in rheumatoid and non-rheumatoid inflammatory arthritis. METHODS: Peripheral blood (PBMC) and synovial (SFMC) mononuclear cells were isolated from subjects with rheumatoid arthritis (n = 16) and non-rheumatoid inflammatory arthritis (n = 12). PBMC were isolated from six healthy controls. Expression of CD122 was examined using indirect immunofluorescence and quantitative flow cytometry. RESULTS: There was no difference in IL-2Rp75 expression on PBMC from rheumatoid arthritis patients, non-rheumatoid arthritis patients, and controls. In subjects with rheumatoid arthritis there was no difference in IL-2Rp75 expression on PBMC and SFMC. However, in the non-rheumatoid arthritis group there was an increase in IL-2Rp75 expression on SFMC compared with PBMC (P = 0.0032). On SFMC there was a greater expression of IL-2Rp75 in non-rheumatoid arthritis than in rheumatoid arthritis (P = 0.0007). Expression was greater on CD8 positive cells and in subjects with shorter duration of disease. CONCLUSIONS: The p75 chain of the IL-2 receptor, an important T cell activation antigen, is not upregulated in synovial fluid. This appears to be a disease specific defect and provides further support for the concept of "frustrated" or incomplete T cell activation in this disease.
How to assess the severity of bronchiectasis
Authors: Aarash D. Saleh, John R. Hurst
Journal: European Respiratory Journal (2014)

When assessing the 'severity' of bronchiectasis, consider both imaging and clinical variables http:// ow.ly/tGRLS Wait long enough for a bus and two arrive at once.As with buses, so with bronchiectasis scoring systems.In this issue of the European Respiratory Journal MARTINEZ-GARCIA et al.[1] report the development of a ''FACED'' bronchiectasis prognostic score.This follows the recent publication by CHALMERS et al.[2] of the ''Bronchiectasis Severity Index'' (BSI).Bronchiectasis is a neglected disease and research in the area is to be welcomed, especially when it enables us to manage our patients more appropriately.But, like any good research, these studies raise as many questions as answers: most importantly, what do we even mean when we talk about bronchiectasis ''severity''?
Tenure of Medical Offices—Health Officer—Sanitary Affairs —Other Matters.
Authors: H. L. E. Johnson
Journal: JAMA (1894)

Washington, D. C., Aug. 4, 1894. <h3>To the Editor:</h3> —The Commissioners of the District of Columbia have adopted a rule limiting the term of service of police surgeons, physicians to the poor, and health officer to three years. Heretofore there has been no limitation to time of service—the new rule does not prevent re-appointment to office. Dr. C. M. Hammett, who three years ago succeeded Dr Smith Townshend as Health Officer, tendered his resignation to the Commissioners on July 31, and it has been accepted. Dr. Hammett has been a successful practitioner in this city for twenty-five years and is a very accomplished gentleman. During his term of service in the health office he had many opportunities to exhibit his skill and judgment which he always did to the entire satisfaction of the profession and the public. He greatly improved the system of medical care of the poor, re-arranging the
NARCOSIS AS THERAPY IN NEUROPSYCHIATRIC CONDITIONS
Authors: W. J. BLECKWENN
Journal: JAMA (1930)

By narcosis I mean a state of deep sleep or unconsciousness, more or less prolonged, and quite rapidly induced by means of drugs; a condition similar to the state of general anesthesia necessary for surgical operation, but not as profound. There is reported herewith the effect of narcosis in certain mental states, and its use as a therapeutic measure in the clinical management of various neuropsychiatric conditions. Before taking up the conditions in which deep sleep has been a decidedly beneficial therapy, I wish to emphasize, what seems quite unnecessary, the essential need of sleep in man and animal as well. Sleep is a biologic reaction of defense on the part of the animal organism against fatigue. Any disturbance of this natural cycle is attended with grave results. The continuous loss of sleep over a period of from five to seven days is incompatible with life. In all probability, the
Dietary fatty acids in dementia and predementia syndromes: Epidemiological evidence and possible underlying mechanisms
Authors: Vincenzo Solfrizzi, Vincenza Frisardi, Cristiano Capurso, Alessia D’Introno, Anna M. Colacicco, Gianluigi Vendemiale, Antonio Capurso, Francesco Panza
Journal: Ageing Research Reviews (2009)
TCT-45 Use of drug-eluting stent (DES) with bioresorbable polymer in patients with ST-segment elevation myocardial infarction (STEMI) - Mid- and long-term clinical outcomes
Authors: Andres Iñiguez, Bernard Chevalier, Thomas Hovasse, Marie-Claude Morice, Alexander G. Osiev, Jawed Polad, Antonio Serra
Journal: Journal of the American College of Cardiology (2013)
Marxist View of Medicine
Authors: T. RAMAKRISHNAN
Journal: Annals of Internal Medicine (1978)

Letters and Corrections1 December 1978Marxist View of MedicineT. RAMAKRISHNAN, M.D.T. RAMAKRISHNAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-89-6-1005 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Dr. Waitzkin (1) and his Marxists consider Third World physicians as belonging to the bourgeoisie and bemoan their defection to the First World. Should they not rejoice that the Third World bourgeoisie, robbed of its intellectual elite, will succumb earlier to the onslaught of the revolutionary proletariat? I can understand their sorrow that "imperialism reinforces international class relations and medicine contributes to this phenomenon." But they would do well to ponder why the proletariat, contrary to Marx's expectations, has not broken national boundaries but rather is breaking heads in boundary wars—Russia versus China, China versus Vietnam, and...Reference1. WAITZKIN H: A Marxist view of medical care. Ann Intern Med 89:264-278, 1978 LinkGoogle Scholar1. WAITZKIN H: A Marxist view of medical care. Ann Intern Med 89:264-278, 1978 LinkGoogle Scholar1. WAITZKIN H: A Marxist view of medical care. Ann Intern Med 89:264-278, 1978 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Lafayette Charity Hospital Lafayette, LA 70502 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByMarxismVLADO SIMKO, M.D. 1 December 1978Volume 89, Issue 6Page: 1005-1006KeywordsMotivation Issue Published: 1 December 1978 PDF DownloadLoading ...
Nicorandil and ulcerations: a NAD/NADP and nicotinic acid-dependent side-effect?
Authors: P. Trechot, A. Barbaud, N. Petitpain, A. Claeys, J.-L. Schmutz
Journal: British Journal of Dermatology (2008)

Conflicts of interest: none declared. Sir, Nicorandil is a vasodilator used to control angina by decreasing cardiac preload and afterload. Since our initial case report in 1997 of nicorandil‐induced major aphthous stomatitis,1 many authors have described single and multiple localizations of similar nicorandil‐induced ulcerations in anal, perianal, vulval, perivulval, intestinal, colonic and peristomal locations. Cutaneous ulcerations have recently been reported, sometimes even at a distance from mucosal ulcerations, and the theoretical link between fistulating bowel disease and nicorandil therapy is currently being investigated.2 3–4 Today, the mechanism of these adverse drug reactions remains unknown but is thought to involve the toxicity of the drug or its metabolites as well as vascular steal phenomenon in vulnerable sites.2 The hypothetical interaction between the metabolic pathways of nicorandil and the endogenous pool of nicotinamide adenine dinucleotide/phosphate (NAD/NADP) is proposed here for the first time. Nicotinamide and nicotinic acid, also called niacin, vitamin B3 or vitamin PP (pellagra preventing), are naturally occurring water‐soluble substances widely distributed in human tissues. The daily requirement ranges from 15 to 20 mg, and they originate mainly from yeast, meat, fish, potatoes, green vegetables and wholemeal cereals. Nicotinic acid is also synthesized from dietary tryptophan, via vitamin B6 coenzyme. Both nicotinamide and nicotinic acid belong to the endogenous pool of NAD/NADP derivatives.5
Sickle cell disease in nonblack persons
Authors: D. R. Powars
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Estrogen and Dementia
Authors: Lon S. Schneider
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Myocarditis as a precipitating factor for heart failure: evaluation and 1‐year follow‐up using cardiovascular magnetic resonance and endomyocardial biopsy
Authors: Sophie Mavrogeni, Costas Spargias, Costas Bratis, Genovefa Kolovou, Vyron Markussis, Evangelia Papadopoulou, Pantelis Constadoulakis, Miltiadis Papadimitropoulos, Marouso Douskou, Gregory Pavlides, Denis Cokkinos
Journal: European Journal of Heart Failure (2011)
High‐energy phosphotransfer in the failing mouse heart: role of adenylate kinase and glycolytic enzymes
Authors: Dunja Aksentijević, Craig A. Lygate, Kimmo Makinen, Sevasti Zervou, Liam Sebag‐Montefiore, Debra Medway, Hannah Barnes, Jurgen E. Schneider, Stefan Neubauer
Journal: European Journal of Heart Failure (2010)
Pan-cancer network analysis identifies combinations of rare somatic mutations across pathways and protein complexes
Authors: Mark D M Leiserson, Fabio Vandin, Hsin-Ta Wu, Jason R Dobson, Jonathan V Eldridge, Jacob L Thomas, Alexandra Papoutsaki, Younhun Kim, Beifang Niu, Michael McLellan, Michael S Lawrence, Abel Gonzalez-Perez, David Tamborero, Yuwei Cheng, Gregory A Ryslik, Nuria Lopez-Bigas, Gad Getz, Li Ding, Benjamin J Raphael
Journal: Nature Genetics (2014)
European cooperation in gastroenterology.
Authors: C Arvanitakis
Journal: Gut (1995)

First beginningsThe necessity for European cooperation in gastroenterology is an old idea, which was first promulgated by the Belgian surgeon and radiologist Georges Brohee .This visionary man was the prime mover in organising the First International Congress of Gastroenterology in Brussels, 60 years ago, in 1935.This congress was a seminal event and marked the birth of European and, indeed, global cooperation in gastroenterology.'On the last day of the congress, 10 August 1935, the Societe International de Gastroenterologie (SIGE) was founded.There were 12 founding member societies, nine from Europe (Belgium, France, Germany, Great Britain, Italy, Netherlands, Poland, Spain, and Switzerland) and three from the Americas (Argentina, Canada, and United States).The Organization Mondial de Gastroenterologie (OMGE), developed historically from SIGE, it was founded in Paris in 1954 and constituted in Washington DC in 1958.In recognition of Brohee's contribution to global cooperation in gastroenterology, OMGE honours his memory with a medal and a lecture delivered at the quadrennial World Congress of Gastroenterology.After the Second World War, Brohee was again instrumental in organising an assembly of delegates of national societies of gastroenter- ology to deliberate and decide on the future of SIGE.A consensus at a global scale could not be reached, but it was decided to move towards the formation of a European forum.This idea bore fruit and on 11 October 1947, the Association des Societes Nationales Europeennes et Mediterraneennes de Gastroenterology (ASNEMGE) was founded.ASNEMGE and the dawn of European cooperation in gastroenterology ASNEMGE as a federation of national European and Mediterranean Societies of
Interpersonal Processes in Depression
Authors: Jennifer L. Hames, Christopher R. Hagan, Thomas E. Joiner
Journal: Annual Review of Clinical Psychology (2013)

Humans have an intrinsic need for social connection; thus, it is crucial to understand depression in an interpersonal context. Interpersonal theories of depression posit that depressed individuals tend to interact with others in a way that elicits rejection, which increases their risk for future depression. In this review, we summarize the interpersonal characteristics, risk factors, and consequences of depression in the context of the relevant theories that address the role of interpersonal processes in the onset, maintenance, and chronicity of depression. Topics reviewed include social skills, behavioral features, communication behaviors, interpersonal feedback seeking, and interpersonal styles as they relate to depression. Treatment implications are discussed in light of the current research on interpersonal processes in depression, and the following future directions are discussed: developing integrative models of depression, improving measurement of interpersonal constructs, examining the association between interpersonal processes in depression and suicide, and tailoring interventions to target interpersonal processes in depression.