tbuckley/cabot-search huggingface dataset:
Persistent polyclonal B lymphocytosis
Authors: Simona Deplano, Elizabet Nadal-Melsió, Barbara J. Bain
Journal: American Journal of Hematology (2013)

Immunophenotyping showed that B cells accounted for more than half of total nucleated cells. They expressed CD19, CD20, CD22, CD79b and CD200 but not CD5, CD10 or CD11c; FMC7 and CD123 were expressed on only a minority of cells. Lymphocytes were polytypic (kappa: lambda 1.5: 1). Around 6% had a higher forward scatter (larger) and these were also polytypic. Fluorescence in situ hybridisation showed no abnormality of chromosome 3. Immunoglobulin M was increased to 10.86 g/l (normal range 0.5-1.9) with no paraprotein band being detected on immunofixation. The patient smoked 10 cigarettes per day. Persistent polyclonal B lymphocytosis is an uncommon condition that is strongly linked to cigarette smoking. The majority of reported cases have been in women. It is linked to HLA-DR7 and familial cases have been reported. Curiously, although the lymphocytes are polyclonal, recurrent cytogenetic abnormalities have been described, particularly i(3)(q), trisomy 3 and dup(3)(q26q29). The presence of binucleated lymphocytes is the distinctive feature that permits the diagnosis to be suspected with a high degree of reliability, even sometimes in patients who lack an increase in the absolute lymphocyte count.
With either separate or integrated arrays of senses, perception may not be direct
Authors: Anatol G. Feldman, Francis G. Lestienne
Journal: Behavioral and Brain Sciences (2001)

The information required for perception may be available in the energy arrays that stimulate sensory organs but in a form not directly suitable for the planning and execution of the organism's actions in the environment. The requisite form of information is obtained, with no loss of adequate perception, by representation of sensory stimuli in frames of reference determined by internal control signals producing actions. This process seems evolutionarily advantageous but makes perception essentially non-direct, regardless of the degree of intra- or inter-modal sensory integration.
Extension of myocardial necrosis into normal epicardium following hypotension during experimental coronary occlusion
Authors: L. W V DEBOER, R. E RUDE, R. F DAVIS, P. R MAROKO, E. BRAUNWALD
Journal: Cardiovascular Research (1982)

In an effort to determine the manner in which hypotension following experimental coronary occlusion affects myocardial infarct size, the left anterior descending coronary artery was occluded in 22 barbiturate anaesthetised dogs, the chest was closed, and the dogs allowed to recover. Thirty minutes following coronary occlusion, seven dogs were haemorrhaged to a mean arterial pressure of 8.2 +/- 0.3 kPa (62 +/- 2 mmHg) and maintained at this pressure; no intervention was undertaken in control dogs. Twenty-four hours after coronary occlusion infarct size in control and hypotensive animals was determined. The hypotensive group developed larger percentages of necrosis of the left ventricles distal to the site of occlusion than did the control dogs (37.8 +/- 2.3 vs 30.4 +/- 1.4 (P less than 0.01)). Although the percentage of infarcted endocardium did not change significantly, the infarction of epicardium was 45% larger in the hypotensive group (34.4 +/- 3.3% vs 23.7 +/- 1.9%, P less than 0.01). Regional myocardial blood flow (RMBF) was determined by means of radioactive microspheres in 5 dogs following coronary occlusion before and after hypotension. RMBF following haemorrhage fell by an equal proportion, 61.9 +/- 3.3% in normal tissue and 61.2 +/- 2.4% in ischaemic zones. In conclusion, hypotension caused infarct extension into the epicardium, ie, into tissue that does not become necrotic under control conditions.
EXPERIENCE WITH AN EPIDEMIC OF RABIES IN BUFFALO.
Authors: ERNEST WENDE
Journal: JAMA (1901)

An important fact to be gathered from history is the liability of human beings to be attacked by diseases of a contagious nature, transmitted through the agency of inferior animals. These diseases often present such unusual features of interest and severity as to engage the serious attention of the local health authorities, and alarm the public generally; and none more so than rabies, on account of its cruel character, distressing anxiety, mortality, its ever-present source—the dog—and the unfortunate dispute as to its actual existence. It is a much easier and more popular task to dilate concerning the habits and good traits of this inseparable companion, than to describe the peculiar morbid manifestations which can not be considered apart from or independent of the other mammalia that have been infected through his bite. It must be viewed in conjunction with man. if we would hope to form a just, enlarged and
Structural Analysis of the STING Adaptor Protein Reveals a Hydrophobic Dimer Interface and Mode of Cyclic di-GMP Binding
Authors: Songying Ouyang, Xianqiang Song, Yaya Wang, Heng Ru, Neil Shaw, Yan Jiang, Fengfeng Niu, Yanping Zhu, Weicheng Qiu, Kislay Parvatiyar, Yang Li, Rongguang Zhang, Genhong Cheng, Zhi-Jie Liu
Journal: Immunity (2012)
The Impact of Routine Admission Chest X-Ray Films on Patient Care
Authors: F. Allan Hubbell, Sheldon Greenfield, Judy L. Tyler, Kotta Chetty, Frederic A. Wyle
Journal: New England Journal of Medicine (1985)

We evaluated the impact of routine chest x-ray films, obtained on admission, on the treatment of patients on internal medicine wards of the Veterans Administration Medical Center, Long Beach, California--a population known to have a high prevalence of cardiopulmonary disease. The reasons for ordering chest films were determined prospectively, and three Department of Medicine faculty members reviewed the charts of admitted patients to determine the impact of chest-film results on patient care. Routine chest x-ray films were ordered for 294 (60 per cent) of the 491 patients studied. Abnormalities were noted in 106 (36 per cent) of these 294 patients. The findings were previously known, chronic, and stable in 86 patients; they were new in only 20. Treatment was changed because of chest-film results in only 12 (4 per cent) of the patients. In only one of these patients would appropriate treatment probably have been omitted if a chest film had not been obtained, and the patient's outcome was not improved by the treatment instituted. We conclude that the impact of routine admission chest x-ray films on patient care is very small, even in a population with a high prevalence of cardiopulmonary disease. We recommend that such films not be ordered solely because of admission.
Dissociation between reperfusion induced arrhythmias and increases in ventricular 1 receptor density in the anaesthetised rat
Authors: A. S MANNING, R. CROME, N. KLEIN, D. J HEARSE, M. E MAGUIRE
Journal: Cardiovascular Research (1989)

Journal Article Dissociation between reperfusion induced arrhythmias and increases in ventricular α1 receptor density in the anaesthetised rat Get access ALLAN S MANNING, ALLAN S MANNING a **From Cardiovascular Research, The Rayne Institute, St Thomas' s Hospital, London SE1 7EH, USA aPresent address: Department of Biology, Roche Products Ltd, Welwyn Garden City. Search for other works by this author on: Oxford Academic PubMed Google Scholar RENATA CROME, RENATA CROME a **From Cardiovascular Research, The Rayne Institute, St Thomas' s Hospital, London SE1 7EH, USA aPresent address: Department of Biology, Roche Products Ltd, Welwyn Garden City. Search for other works by this author on: Oxford Academic PubMed Google Scholar NINA KLEIN, NINA KLEIN †From Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar DAVID J HEARSE, DAVID J HEARSE **From Cardiovascular Research, The Rayne Institute, St Thomas' s Hospital, London SE1 7EH, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar MICHAEL E MAGUIRE MICHAEL E MAGUIRE †From Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 23, Issue 10, October 1989, Pages 852–858, https://doi.org/10.1093/cvr/23.10.852 Published: 01 October 1989 Article history Accepted: 26 April 1989 Published: 01 October 1989
Chronic Left Ventricular Bypass with an Implantable Ventricular-Aortic Assist Pump
Authors: WILLIAM F. BERNHARD, C. G. LAFARGE, H. JOCKIN, S. KITRILAKIS, T. ROBINSON
Journal: Circulation (1969)

This investigation represents definite progress in the field of assisted circulation. Experiments involved the maintenance of partial left ventricular bypass in 25 calves by means of a new, implantable, left ventricular assist pump. Flow rates of 800 to 3,000 ml/ min were employed continuously for periods of 6 to 120 days. Flocked Dacron fibrils were applied to all pump surfaces to serve as a matrix for adherence of a fibrin-cellular (pseudoendothelial) layer. Serial hematological studies carried out during assisted circulation did not disclose any evidence of severe blood damage.
Thallium-201 Scintigraphy Is an Effective Diagnostic Modality to Distinguish Malignant From Benign Soft-Tissue Tumors
Authors: Naoaki Kawakami, Toshiyuki Kunisada, Shuhei Sato, Yuki Morimoto, Masato Tanaka, Tsuyoshi Sasaki, Shinsuke Sugihara, Hiroyuki Yanai, Susumu Kanazawa, Toshifumi Ozaki
Journal: Clinical Nuclear Medicine (2011)

The aim of this study is to evaluate whether thallium-201 (201-Tl) scintigraphy can differentiate malignant from benign soft-tissue tumors.Between April 1995 and December 2005, 192 patients with soft-tissue tumors (85 malignant and 107 benign) underwent 201-Tl scintigraphy before treatment. Isotope uptake was used as a proxy for tumor-to-background ratio (TBR). The accuracy of TBR on early and delayed imaging was evaluated using the Mann-Whitney U and χ(2) tests.There was a statistically significant difference in mean TBR on early and delayed imaging of malignant and benign soft-tissue tumors (124% ± 109% vs. 22% ± 42%, and 82% ± 83% vs. 12% ± 25%, P < 0.0001). A TBR cutoff of 20% indicated the probability of malignancy on early and delayed imaging (82% sensitivity and 77% specificity; 82% sensitivity and 84% specificity, P < 0.0001). Well-differentiated liposarcomas showed low isotope accumulation, while pigmented villonodular synovitis and giant cell tumors of the tendon sheath showed high isotope accumulation.Thallium-201 scintigraphy can distinguish malignant from benign tumors with relatively high accuracy. With the exception of low grade liposarcomas and locally aggressive benign tumors, 201-Tl scintigraphy may be an effective diagnostic modality to differentiate malignant from benign soft-tissue tumors.
Scintigraphy of Lower Extremity Cadaveric Bone Allografts in Osteosarcoma Patients
Authors: ZVI BAR-SEVER, LEONARD P. CONNOLLY, MARK C. GEBHARDT, S. TED TREVES
Journal: Clinical Nuclear Medicine (1997)

Purpose: To describe scintigraphic characteristics of bone allografts used in limb salvage reconstruction after resection of lower extremity osteosarcoma. Materials and Methods: The authors reviewed 85 skeletal scintigrams of 20 pediatric patients followed up for 0.5-5.7 years after resection of lower extremity osteosarcoma and allograft reconstruction. Uptake in the allograft and adjacent host tissues was assessed visually. Results: Lack of tracer uptake in the allografts was seen in 99% of the studies and a faint rim of tracer localization outlining the allograft's periphery was seen in 95% of the studies. Increased uptake was noted at the allograft-host bone junction in 78% of the studies. Uptake was increased in the joint surfaces of native bones articulating with allografts (97% of studies), including the patella (93% of studies) when the knee was involved. These findings were stabilized as time passed. Conclusion: Cadaveric bone allografts have a characteristic scintigraphic appearance in this selected patient group that reflects the physiology of their incorporation process.
Preparation for Marriage, A Medical, Religious, Legal and Civic Responsibility.
Authors: Alice Baker Holoubek
Journal: Annals of Internal Medicine (1973)

Meeting Abstracts1 May 1973Preparation for Marriage, A Medical, Religious, Legal and Civic Responsibility.Alice Baker Holoubek, M.D., Joe E. Holoubek, M.D., F.A.C.P., James R. Bergeron, M.D.Alice Baker Holoubek, M.D.Search for more papers by this author, Joe E. Holoubek, M.D., F.A.C.P.Search for more papers by this author, James R. Bergeron, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-5-830_4 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Excerpt"The formation of the most important person in the world, my spouse" is the theme of the Pre-Marriage Conferences that we have directed for the past 15 years. The discussions are so arranged that they should enable each engaged couple to think out what love and marriage really means to them and to offer some understanding of the many factors, positive and negative, which will influence the success of their marriage. Thus, a happy marriage and family life are our goals, and we believe that these are the very sinews that bind our civilization together.Marriage is a vocation that... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Shreveport, Louisiana. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1973Volume 78, Issue 5Page: 830-830 Issue Published: 1 May 1973 PDF DownloadLoading ...
Ethics Consultation Quality: Is Evaluation Feasible?
Authors: Donald F. Phillips
Journal: JAMA (1996)

LIKE MEDICINE in general, biomedical ethics is in a state of flux, and for those involved in ethics case consultation, changes have been dramatic. Originally patterned after the medical consult model, ethics consultations have been provided for the last 20 years or so for physicians who requested such advice, and have usually been performed by physicians with some special training in ethics, law, or philosophy. But as consensus emerged during the last decade about what the process of ethics consultation should entail, it became apparent that the physician's perspective was often insufficient for resolving many of the problems presented. Gradually, other health care professionals—particularly nurses, clergy, and social workers—who were in a position to contribute social, psychological, and cultural insights, were accepted as participants in the ethics decision-making process. In addition, institutional ethics committees, which were formed during the past decade in many of the nation's acute care settings, fostered
Virus-induced type I IFN stimulates generation of immunoproteasomes at the site of infection
Authors: Eui-Cheol Shin, Ulrike Seifert, Takanobu Kato, Charles M. Rice, Stephen M. Feinstone, Peter-M. Kloetzel, Barbara Rehermann
Journal: Journal of Clinical Investigation (2006)

IFN-gamma is known as the initial and primary inducer of immunoproteasomes during viral infections. We now report that type I IFN induced the transcription and translation of immunoproteasome subunits, their incorporation into the proteasome complex, and the generation of an immunoproteasome-dependent CD8 T cell epitope in vitro and provide in vivo evidence that this mechanism occurs prior to IFN-gamma responses at the site of viral infection. Type I IFN-mediated generation of immunoproteasomes was initiated by either poly(I:C) or HCV RNA in human hepatoma cells and was inhibited by neutralization of type I IFN. In serial liver biopsies of chimpanzees with acute HCV infection, increases in immunoproteasome subunit mRNA preceded intrahepatic IFN-gamma responses by several weeks, instead coinciding with intrahepatic type I IFN responses. Thus, viral RNA-induced innate immune responses regulate the antigen-processing machinery, which occurs prior to the detection of IFN-gamma at the site of infection. This mechanism may contribute to the high effectiveness (95%) of type I IFN-based therapies if administered early during HCV infection.
Chemoembolisation with lipiodol and doxorubicin: applicability in British patients with hepatocellular carcinoma.
Authors: S D Ryder, P M Rizzi, E Metivier, J Karani, R Williams
Journal: Gut (1996)

Chemoembolisation has been extensively used as primary treatment for unresectable hepatocellular carcinoma (HCC). In this unit, 185 patients with a new diagnosis of HCC not amenable to surgery were seen between 1988 and 1991. Intended therapy for these patients was chemoembolisation with doxorubicin (60 mg/m2) and lipiodol, repeated at six week intervals until it was technically no longer possible or until complete tumour response had been obtained. Chemoembolisation was possible in 67 of the 185 (37%). Reasons for exclusion were portal vein occlusion (n = 36), decompensated cirrhosis (n = 44), distant metastases (n = 5), diffuse tumour or unsuitable anatomy (tumour or vasculature) (n = 11), patient refusal (n = 11), and other (n = 11). Patients excluded from treatment survived for a median of 10 weeks (range 3 days-19 months). In patients treated, 18 had small HCC (&lt; 4 cm) and 49 had large or multifocal HCC. Chemoembolisation was carried out a median of two sessions for small and three sessions for large tumours. Ten of 18 patients with small HCC showed a 50% or greater reduction in tumour size. Five of 49 patients with large or multifocal tumours showed a response to treatment. Median overall survival for treated patients was 36 weeks (range 3 days-4 years). One patient has subsequently undergone liver transplantation with no recurrence and minimal residual disease at transplantation. Two other patients are alive three years after chemoembolisation, one with no evidence of recurrent disease. No patient was thought suitable for surgery after their response to chemoembolisation. Chemotherapy related complications were seen in 22%. Complications were significantly more common in patients with larger tumours and poor liver reserve. Five patients died as a result of chemotherapy related complications. In conclusion, only one third of UK patients with unresectable HCC are treatable by chemoembolisation. Results with small tumours are encouraging, with a high response rate and the possibility of surgical intervention in previously inoperable disease. Large tumours, however, show a poor response and a significant incidence of side effects, suggesting that this treatment offers little benefit in advanced disease.
Ileal obstruction in a 73-year-old woman
Authors: C-H Tseng, W-L Wang, T-C Lee, T-H Lee, H-P Wang
Journal: Gut (2009)

A 73-year-old woman presented to our emergency department with complaints of progressive abdominal fullness and vomiting for 2 months. Her past history was unremarkable apart from breast cancer 10 years …
Role of airway eosinophils in the development of allergen-induced airway hyperresponsiveness in dogs.
Authors: M J Woolley, C G Lane, R Ellis, W H Stevens, K L Woolley, P M O'Byrne
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

The role of the eosinophil in the development of allergen-induced airway hyperresponsiveness is uncertain. We examined whether the development of airway hyperresponsiveness in 17 dogs after inhalation of Ascaris suum allergen (10(-6) to 10(-2) weight/volume [w/v]) was associated with increases in the number and level of activation of eosinophils before and after allergen inhalation. Airway responsiveness to inhaled acetylcholine was measured before and 24 h after Ascaris inhalation. Eosinophil number was assessed by bronchoalveolar lavage performed 1 wk before allergen inhalation and 15 min after the 24 h acetylcholine challenge. Dogs that developed Ascaris-induced airway hyperresponsiveness (n = 8) had a significantly greater number of bronchoalveolar lavage eosinophils before allergen inhalation (mean +/- SEM: 4.6 +/- 1.94 x 10(4) cells/ml) than dogs that did not become hyperresponsive (n = 9) (1.2 +/- 0.81 x 10(4) cells/ml) (p = 0.03). Ascaris-induced airway hyperresponsiveness, measured 24 h after allergen inhalation, was not associated with increases in eosinophil number after allergen challenge. These results suggest that the presence of airway eosinophils before allergen inhalation is necessary for the development of allergen-induced airway hyperresponsiveness.
Persistence of a reduced-collagen-producing phenotype in cultured scleroderma fibroblasts after short-term exposure to interferons.
Authors: M R Duncan, B Berman
Journal: Journal of Clinical Investigation (1987)

Transient exposure to inflammation-associated, fibroblast-stimulatory factors appears to initiate fibrosis by inducing the persistently activated phenotypes displayed by fibroblast cultures derived from scleroderma skin and other fibrotic tissues. To determine whether one class of fibroblast-inhibitory factors, the interferons (IFNs), plays a role in terminating fibrosis by acting as persistent fibroblast deactivators, we inhibited (40-60%) the growth and collagen production of normal dermal fibroblasts and hypercollagen-producing scleroderma fibroblasts by short-term exposure to IFN-alpha, beta, or gamma. During subsequent subculture in the absence of IFNs, the growth and collagen production of normal fibroblasts and the growth of scleroderma fibroblasts increased to untreated control levels after two to three passages. In contrast, collagen production by scleroderma fibroblasts remained inhibited for at least five passages (18 cell doublings) and was not further suppressed by subsequent IFN exposure. These data suggest that IFNs may help terminate fibrosis by suppressing persistently activated fibroblast functions.
Expression of a Truncated Cystic Fibrosis Transmembrane Conductance Regulator with an AAV5-pseudotyped Vector in Primates
Authors: Anne C Fischer, Carolina I Smith, Liudmila Cebotaru, Xuemei Zhang, Frederic B Askin, Jerry Wright, Sandra E Guggino, Robert J Adams, Terence Flotte, William B Guggino
Journal: Molecular Therapy (2007)

Gene therapy using recombinant adeno-associated virus (rAAV2) vectors for cystic fibrosis has shown gene transfer and remarkable safety, yet indeterminate expression. A new construct has been characterized with a powerful exogenous promoter, the cytomegalovirus enhancer/chicken beta-actin promoter, driving a truncated CF transmembrane conductance regulator (CFTR), pseudotyped in an AAV5 viral coat. Our goal is to demonstrate that airway delivery of a pseudotyped rAAV5 vector results in gene transfer as well as expression in non-human primates. Aerosolized pseudotyped rAAV5-DeltaCFTR or rAAV5-GFP (green fluorescent protein) genes were delivered to four and six lungs, respectively. The pseudotyped rAAV5 vector did result in GFP gene transfer (1.005x10(6) copies/mug DNA on average) and quantifiable gene expression. Microscopy confirmed protein expression in airway epithelium. Similarly, the vector also resulted in vector-specific CFTR DNA (1.24x10(5) copies/microg) and mRNA expression. Immunoprecipitation and (32)P phosphoimaging were used to demonstrate CFTR protein expression, as qualitatively enhanced beyond the barely detectable endogenous expression in untreated animals. Based on these promising studies, this CFTR minigene construct is a therapeutic candidate.
Mammography after treatment for breast cancer
Authors: S J A Powis
Journal: BMJ (1994)

We agree that there is no evidence to support the use of dexamethasone in meningococcal septicaemia.As previously highlighted, we did not find any evidence of benefit when it was used in meningococcal meningitis either.We reiterate that further clinical studies are urgently required to clarify these important issues.