tbuckley/cabot-search huggingface dataset:
THE EFFECT OF TESTICLE EXTRACT AND OF NORMAL SERUM ON A TRANSPLANTABLE EPITHELIAL TUMOR OF THE RABBIT
Authors: F. Duran-Reynals
Journal: The Journal of Experimental Medicine (1931)

Extract of rat, rabbit or bull testicle prevents or retards the growth of a rabbit tumor when a mixture of the extract and a tumor cell suspension is inoculated intradermally. Similar mixtures, made with normal rabbit serum instead of testicle extract, give rise to tumors which grow with unusual rapidity. The results are the opposite of those obtained with pathogenic bacteria or filtrable viruses which are enhanced by testicle extract and generally inhibited by normal serum.
The Right to Psychiatric Treatment: A “Simple Decision” in the Supreme Court
Authors: William J. Curran
Journal: New England Journal of Medicine (1975)

A finding of "mental illness" alone cannot justify a State's locking up a person against his will and keeping him indefinitely in simple custodial confinement. [Mr. Justice Stewart]THE idea of a constitutional right to psychiatric treatment has been around now for some 15 years, having been articulated by Morton Birnbaum in an article in the American Bar Association Journalin 1960.1 It received statutory recognition in the District of Columbia in 1965 and was supported in an opinion by Judge David Bazelon in 1966.2 In this first case, the specific basis of the opinion was the 1965 statute, which . . .
Condyloma-like lesions as the presenting sign of multiple Myeloma associated amyloidosis
Authors: G.F. Buezo, P.F. Penas, J. Firaga, A. Alegre, M. Aragüues
Journal: British Journal of Dermatology (1996)

Journal Article Condyloma‐like lesions as the presenting sign of multiple Myeloma associated amyloidosis Get access G.F. Buezo, G.F. Buezo Department of Dermatology, Hospital Universitario de la Princesa, Universidad Autonóma, Madrid, Spain Search for other works by this author on: Oxford Academic Google Scholar P.F. Penas, P.F. Penas Department of Dermatology, Hospital Universitario de la Princesa, Universidad Autonóma, Madrid, Spain Search for other works by this author on: Oxford Academic Google Scholar J. Firaga, J. Firaga Department of Pathology, Hospital Universitario de la Princesa, Universidad Autonóma, Madrid, Spain Search for other works by this author on: Oxford Academic Google Scholar A. Alegre, A. Alegre Department of Haematology, Hospital Universitario de la Princesa, Universidad Autonóma, Madrid, Spain Search for other works by this author on: Oxford Academic Google Scholar M. Aragüues M. Aragüues Department of Dermatology, Hospital Universitario de la Princesa, Universidad Autonóma, Madrid, Spain Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 135, Issue 4, 1 October 1996, Pages 665–666, https://doi.org/10.1111/j.1365-2133.1996.tb03867.x Published: 01 October 1996
Phase II Price Controls—An Overview
Authors: Francis C. Coleman
Journal: JAMA (1972)

On Aug 15, 1971, the President of the United States outlined on nationwide television, a rather significant departure from the then existing economic policy of the federal government. The specific aspect of the program that has had the most direct impact on physicians relates to the steps the President took to stem inflation. On Oct 7, several weeks before the initial 90-day moratorium on wages and prices expired, the President made a second address announcing some of the details of a more permanent program that came to be known as Phase II. As part of Phase II, a Committee on the Health Services Industry was appointed to deal specifically with prices and wages in the health sector of the economy. Of the four physicians on the 21-member committee, two are currently in private practice. Other members represent a cross section of the health services industry. The Committee on the Health
Cumulative Effects Associated With Recurrent Concussion in Collegiate Football Players
Authors: Kevin M. Guskiewicz, Michael McCrea, Stephen W. Marshall, Robert C. Cantu, Christopher Randolph, William Barr, James A. Onate, James P. Kelly
Journal: JAMA (2003)

Approximately 300 000 sport-related concussions occur annually in the United States, and the likelihood of serious sequelae may increase with repeated head injury.To estimate the incidence of concussion and time to recovery after concussion in collegiate football players.Prospective cohort study of 2905 football players from 25 US colleges were tested at preseason baseline in 1999, 2000, and 2001 on a variety of measures and followed up prospectively to ascertain concussion occurrence. Players injured with a concussion were monitored until their concussion symptoms resolved and were followed up for repeat concussions until completion of their collegiate football career or until the end of the 2001 football season.Incidence of concussion and repeat concussion; type and duration of symptoms and course of recovery among players who were injured with a concussion during the seasons.During follow-up of 4251 player-seasons, 184 players (6.3%) had a concussion, and 12 (6.5%) of these players had a repeat concussion within the same season. There was an association between reported number of previous concussions and likelihood of incident concussion. Players reporting a history of 3 or more previous concussions were 3.0 (95% confidence interval, 1.6-5.6) times more likely to have an incident concussion than players with no concussion history. Headache was the most commonly reported symptom at the time of injury (85.2%), and mean overall symptom duration was 82 hours. Slowed recovery was associated with a history of multiple previous concussions (30.0% of those with > or =3 previous concussions had symptoms lasting >1 week compared with 14.6% of those with 1 previous concussion). Of the 12 incident within-season repeat concussions, 11 (91.7%) occurred within 10 days of the first injury, and 9 (75.0%) occurred within 7 days of the first injury.Our study suggests that players with a history of previous concussions are more likely to have future concussive injuries than those with no history; 1 in 15 players with a concussion may have additional concussions in the same playing season; and previous concussions may be associated with slower recovery of neurological function.
MATERIA MEDICA AND PHARMACY IN HOSPITAL PRACTICE.
Authors: M. I. WILBERT
Journal: JAMA (1907)

The practice of pharmacy in American hospitals dates back to 1752, when Jonathan Roberts was duly appointed to preside over the recently established apothecary shop in the Pennsylvania Hospital at Philadelphia. This appointing of an apothecary by the managers of the Pennsylvania Hospital marks the introduction of the dispensing of prescriptions by other than the physician or his apprentice, and may, in fact, be considered as the beginning of pharmacy in this country. The advantage and the importance of this branch of hospital work was further recognized in 1768 by the erection of a special building, or an "elaboratory," in which to prepare the medicines to be used in the treatment of the sick. That the innovation of having prescriptions compounded by other than the physician or his apprentice had a beneficent influence on the medical staff connected with the hospital is perhaps best illustrated by the subsequent career of
Potential of selective sodium-hydrogen exchange inhibitors in cardiovascular therapy
Authors: W. Scholz, U. Albus
Journal: Cardiovascular Research (1995)

Journal Article Potential of selective sodium-hydrogen exchange inhibitors in cardiovascular therapy Get access Wolfgang Scholz, Wolfgang Scholz * Hoechst AG, SBU Cardiovascular Agents, H821, 65926 Frankfurt/Main, Germany *Correspondence to Dr Scholz. Search for other works by this author on: Oxford Academic PubMed Google Scholar Udo Albus Udo Albus Hoechst AG, SBU Cardiovascular Agents, H821, 65926 Frankfurt/Main, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 29, Issue 2, February 1995, Pages 184–188, https://doi.org/10.1016/S0008-6363(96)88568-3 Published: 01 February 1995 Article history Received: 28 April 1994 Accepted: 01 September 1994 Published: 01 February 1995
Treatment of Theophylline Overdose
Authors: Kent R. Olson
Journal: JAMA (1983)

<h3>To the Editor.—</h3> We disagree with the suggestion of Drs Dean and Brown that massive theophylline overdose may be safely treated without hemoperfusion or hemodialysis (1982; 248:1742). Their patient survived a theophylline overdose that produced a peak level of 203 μg/mL. However, her hospital course was precarious, complicated by severe hypotension, recurrent arrhythmias, and repeated grand mal seizures. Although not described in detail, one seizure, which required 20 mg of diazepam in 2.5-mg increments, was most likely prolonged. Prolonged seizures combined with hypotension may result in anoxic brain damage.<sup>1</sup>The patient's "mild memory loss" is not well characterized but raises the question of permanent neurological damage. The pharmacology and toxicology of theophylline have been extensively studied. Our experience at the San Francisco General Hospital and the San Francisco Bay Area Poison Control Center confirms the literature consensus, cited by Dean and Brown, that morbidity and mortality after theophylline overdose
433 LIVER SINUSOIDAL ENDOTHELIAL CELLS INDUCE TGF-β DEPENDENT CONVERSION OF CD4+FOXP3+ REGULATORY T CELLS FROM CONVENTIONAL CD4+CD25-T CELLS
Authors: A. Carambia, S. Huber, S. Lüth, D. Schwinge, C. Frenzel, C. Schramm, A.W. Lohse, J. Herkel
Journal: Journal of Hepatology (2010)
Physical Fitness and Incidence of Hypertension in Healthy Normotensive Men and Women
Authors: Steven N. Blair
Journal: JAMA (1984)

We measured physical fitness, assessed by maximal treadmill testing in 4,820 men and 1,219 women aged 20 to 65 years. Participants had no history of cardiovascular disease and were normotensive at baseline. We followed up these persons for one to 12 years (median, four years) for the development of hypertension. Multiple logistic risk analysis was used to estimate the independent contribution of physical fitness to risk of becoming hypertensive. After adjustment for sex, age, follow-up interval, baseline blood pressure, and baseline body-mass index, persons with low levels of physical fitness (72% of the group) had a relative risk of 1.52 for the development of hypertension when compared with highly fit persons. Risk of hypertension developing also increased substantially with increased baseline blood pressure.
Association in <i>cis</i> of β<sup>+</sup>‐thalassemia and hemoglobin S
Authors: Faouzi Baklouti, Alain Francina, Evelyne Dorléac, Georges Richard, Daniel Rosenberg, Jacqueline Godet, Jean Delaunay
Journal: American Journal of Hematology (1987)

Abstract A Moroccan woman was investigated because of a typical β‐thalassemia trait associated with a low‐percentage (11%) hemoglobin (Hb) variant. The β‐thalassemia trait was manifested by a microcytosis, a high HbA 2 (above 6%), and an increase of the α/β biosynthetic ratio (1.31). The variant was identified to HbS by amino acid analysis of the abnormal peptide (β T1) and by DNA mapping with Sau I (Mst II) restriction endonuclease. No additional amino acid substitution was recorded in the β s ‐chain. The reduction of β‐globin synthesis occurred exclusively at the expense of the β s ‐chain. These results are consistent with the existence of a β s mutation and a β + ‐thalassemia in cis .
Paradoxical Increase in Ventricular Torsion and Systolic Torsion Rate in Type I Diabetic Patients Under Tight Glycemic Control
Authors: Jina Chung, Paul Abraszewski, Xin Yu, Wei Liu, Andrew J. Krainik, Marvin Ashford, Shelton D. Caruthers, Janet B. McGill, Samuel A. Wickline
Journal: Journal of the American College of Cardiology (2005)
Busulfan in Pregnancy
Authors: Lewis H. Dennis
Journal: JAMA (1965)

THE MANAGEMENT of chronic granulocytic leukemia during pregnancy causes much concern among clinicians, because the agents effective in the therapy of this malignant disorder are highly toxic and potentially injurious to fetal development. It has been axiomatic that any treatment given to the mother during pregnancy should not endanger the fetus, and therapy be administered only when the patient is symptomatic. 1 Some have suggested that all chemotherapy be avoided during the first trimester of pregnancy because of the danger of abortion or deformity. 2 This is not always possible, because the patient may conceive while on chemotherapy, or the physician may begin treatment before becoming aware that the patient is pregnant. The number of patients with chronic granulocytic leukemia treated with chemotherapeutic agents during this critical period is few. Reporting the results of such therapy during the period of organogenesis and differentiation is of great importance. The case described
Effect of inadequate adherence on clinical outcomes: results from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate cohort
Authors: James Bluett, Catharine Morgan, Layla Thurston, Darren Plant, Ann Morgan, Anthony Wilson, John Isaacs, Kimme Hyrich, Lis Cordingley, Anne Barton
Journal: The Lancet (2014)
Manpower Needs by Specialty
Authors: Lewis E. Hughes
Journal: JAMA (1972)

To the Editor.—  In reading Mr. Mason's article (219:621, 1972) I was disturbed by the implications raised by figures presented from Kaiser-Permanente, Portland, Ore, in Table 2, entitled Optimum Physician-Population Ratios for 18 Specialties Based on Experience for Six Prepaid Group Plans. The figures supplied by us and reproduced in this Table were in no sense intended to be considered optimum. They represented the existing ratios at the time the information was provided. In several of the departments we considered the staffing to be substantially less than optimum at that time and were vigorously seeking additional physicians.  The most notable example is in the department of obstetrics and gynecology where we expect to achieve and maintain a ratio of one physician to 10,000 members. Staffing ratios listed in the departments of internal medicine, ophthalmology, otolaryngology, and radiology were also below levels we consider optimum.  Summation of the ratios listed in
HIV Infection as Leading Cause of Death Among Young Adults in US Cities and States: 1991
Authors: Richard M. Selik
Journal: JAMA (1994)

<h3>To the Editor.</h3> —Previously, we described the extent to which human immunodeficiency virus (HIV) infection was the leading cause of death in US cities and states in 1990 among men and women aged 25 to 44 years.<sup>1</sup>We have now updated our analysis for 1991, using data recently released by the National Center for Vital Statistics.<sup>2</sup> Among men aged 25 to 44 years, the number of states in which HIV infection was the leading cause of death increased from five in 1990 to nine in 1991. In these nine states, the proportion of deaths caused by HIV ranged from 15% in Rhode Island to 33% in New York, with a median of 21% in Massachusetts (Table). In 1991, HIV infection was not the leading cause of death among women aged 25 to 44 years in any state. In New York and New Jersey, however, where it was the second
Respiratory Function in Disease: An Introduction to the Integrated Study of the Lung
Authors: David W. Cugell
Journal: JAMA (1965)

"An introduction to the integrated study of the lung" is the subtitle of this book and best explains its purpose. In its field it is the most complete text which has appeared to date in the English language. Emphasis is naturally directed toward chronic diseases, since it is in this group of disorders that physiological changes have been best documented. The first quarter of the text is devoted to a thorough but by no means overly detailed review of normal pulmonary physiology, the relevant gross and microscopic anatomy, and a review of normal findings. A survey of all methods used to characterize different lung functions is included, together with many useful tables of normal values. The second quarter of the text deals with the diseases of impeded airways—asthma, emphysema, and chronic bronchitis. Our definitions and understanding of these interrelated disorders have changed substantially in recent years, primarily as a result
Aromatase Inhibitors and Breast Cancer Treatment—Reply
Authors: Steven E. Come
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Safety and magnetic resonance imaging
Authors: I Moseley
Journal: BMJ (1994)

Magnetic resonance imaging entails a strong static magnetic field and changing magnetic and radiofrequency fields. Problems arise from any metal objects present in the body.

With magnetic resonance imaging, the whole body is in the magnetic field, and sensitive organs cannot be “screened” - as they can in most techniques that use ionising radiation. For example, a foreign object in the head can interfere with the magnetic resonance imaging of any part of the body, down to the toes, and the referring doctor and radiologist must be aware of any potential source of interference even if it is physically distant from (and unrelated to) the problem being investigated. Cleaners, engineers, and anyone accompanying the patient during imaging are subject to the same risks: nobody known to harbour or suspected of harbouring any hazardous object should come near the imager. The National Radiological Protection Board's arbitrary recommendation in 1983 that magnetic resonance imaging should not be …
Mechanism of action of antipruritic drugs.
Authors: L Krause, S Shuster
Journal: BMJ (1983)

Astemizole and terfenadine, two potent non-sedative H1 antihistamines, had no effect on itch measured objectively as nocturnal scratching and subjectively on a 10 cm line. Trimeprazine, however, a more sedative but less potent H1 antihistamine, was antipruritic, as was nitrazepam, a sedative benzodiazepine. We concluded (a) that antipruritic drugs act centrally by a property related to sedation; (b) H1 receptor antagonists have a peripheral antipruritic action only when itch is due to histamine release, as in the wealing disorders. Thus the new nonsedative H1 antihistamines have no place in the treatment of itch from other causes.
Reflux Esophagitis Secondary to Chemotherapy Detected by Serial FDG-PET
Authors: Gonca Gul Bural, Rakesh Kumar, Ayse Mavi, Abass Alavi
Journal: Clinical Nuclear Medicine (2005)

A 69-year-old man with colon carcinoma underwent serial fluorine-18 fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) scans for restaging and monitoring the treatment response. He was having symptoms of possible persistent reflux esophagitis following chemotherapy. Serial FDG-PET scans obtained during and after completion of chemotherapy revealed abnormal diffuse FDG uptake in the esophagus in all 3 PET studies. These findings of FDG-PET scans were suggestive of possible postchemotherapy reflux esophagitis.
THE EFFECTS OF INTRAVENOUS PRISCOLINE ON CEREBRAL CIRCULATION AND METABOLISM 1
Authors: P. Scheinberg, I. Blackburn, M. Rich
Journal: Journal of Clinical Investigation (1953)

Priscoline hydrochloride (2-benzyl-imidazolinehydrochloride) is a drug of many pharmacologic actions. The effects of the drug in man apparently depend upon the dosage and method of administration. It is reported to produce peripheral vasodilatation by: 1) adrenergic blockade, inhibiting the effects of circulating adrenalin on smooth muscle cells of blood vessels; 2) sympathetic blockade at the terminations of the sympathetic nerves in the blood vessels; 3) direct action on peripheral vessels; and 4) epinephrine-reversal. There may be sufficient increase in cardiac output to elevate arterial pressure even in the presence of generalized peripheral vasodilatation (1-7). The drug also has other actions not specifically related to the cardiovascular system. Clinically, priscoline has been used widely in the treatment of occlusive and spastic peripheral vascular disease because of its ability to produce an increased cutaneous and muscle blood flow (8-11). Several enthusiastic reports have appeared on the beneficial effects of priscoline on cerebral vessels in the treatment of cerebral vascular disease (1214), and D. Engel has observed dilatation of pial vessels by capillary microscopy through a window in the skull of cats following intravenous priscoline (15). The present study was undertaken in an effort to measure the effects of large doses of intravenous priscoline on cerebral blood flow, metabolism, and other cerebral metabolic functions in man.
Reye's syndrome, aspirin, and juvenile chronic arthritis
Authors: A. Hall, B. M Ansell
Journal: BMJ (1986)

overload is common to all such units (Price DJ, IEE Colloquium 1984).The most sophisticated system will fail in the absence of data entry.Most clinical and nursing staff dislike the usual QWERTY keyboard, the means of data entry favoured by computer systems.The APACHE scoring described by Knaus et al3 shows the APACHE II system as a 9 x 12 box table.We have used this table as an overlay for a pressure sensitive graphics pad.Data entry is by box ticking, allowing direct data acquisition by a microcomputer.This approach does not need a keyboard, uses existing technology, allows data entry by a familiar method, and provides a record of the data actually entered.Nurses (and doctors) did not train to become typists.