ACUTE HEMOLYTIC ANEMIA DUE TO NEOARSPHENAMINE: REPORT OF A FATAL CASE
Authors: Lawrence E. Young, William N. Valentine, Joe W. Howland
Journal: Annals of Internal Medicine (1946)

Case Reports1 January 1946ACUTE HEMOLYTIC ANEMIA DUE TO NEOARSPHENAMINE: REPORT OF A FATAL CASELAWRENCE E. YOUNG, M.D., WILLIAM N. VALENTINE, JOE W. HOWLANDLAWRENCE E. YOUNG, M.D.Search for more papers by this author, WILLIAM N. VALENTINESearch for more papers by this author, JOE W. HOWLANDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-24-1-104 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA case of fatal hemolytic jaundice following injection of neoarsphenamine is described in this report. No descriptions of similar reactions can be found in the literature.Moore1states that "the relative rarity of the blood dyscrasias due to the arsenical drugs is fortunate, since they are among the gravest of treatment complications." He points out that in more than half of the reported cases the blood picture was that of aplastic anemia and 80 per cent of these patients died. Farley2expresses the belief that all blood dyscrasias after arsphenamine therapy are manifestations of varying degrees of depressed bone marrow...Bibliography1. MOORE JE: The modern treatment of syphilis, second edition, 1941, C. C. Thomas, Springfield, Illinois. Google Scholar2. FARLEY DL: Depressed bone marrow function from the arsphenamines, Am. Jr. Med. Sci., 1930, clxxix, 214. CrossrefGoogle Scholar3. DAMESHEKSCHWARTZ WSO: Acute hemolytic anemia, Medicine, 1940, xix, 231. CrossrefGoogle Scholar4. DAMESHEK W: Personal communication, 1944. Google Scholar5. LOVEMAN AB: Toxic granulocytopenia, purpura hemorrhagica and aplastic anemia following the arsphenamines, Ann. Int. Med., 1932, v, 1238. Google Scholar6. MCCARTHYWILSON FPR: The blood dyscrasias following the arsphenamines, Jr. Am. Med. Assoc., 1932, xcix, 1557. CrossrefGoogle Scholar7. HAHN RD: Antisyphilitic treatment: mortality studies, a clinical, statistical, and pathologic analysis of 47 fatal reactions, Am. Jr. Syph., Gonor., and Ven. Dis., 1941, xxv, 659. Google Scholar8. PHELPS JR: Reactions incidental to the administration of 191,778 doses of neoarsphenamine and other arsenical compounds in the United States Navy, U. S. Nav. Med. Bull., 1929, xxvii, 205. Google Scholar9. PROBEYNORRISDEIBERTPRICE TFEWAVEV: Sulfarsphenamine in the therapy of syphilis. A comparative study of the toxic manifestations of neoarsphenamine and sulfarsphenamine, Pub. Health Rep., 1944, lix, 733. CrossrefGoogle Scholar10. CARTERCHAMBERSANDERSON TJWMLT: Toxic effects of arsenical compounds, U. S. Nav. Med. Bull., 1944, xlii, 229. Google Scholar11. WIENER AS: Blood groups and transfusion, third edition, 1943, C. C. Thomas, Springfield, Illinois. CrossrefGoogle Scholar12. FARRARBURNETTSTEIGMAN GEWEAJ: Hemolysinic anemia and hepatic degeneration cured by splenectomy, Am. Jr. Med. Sci., 1940, cc, 164. CrossrefGoogle Scholar13. HAWKINSMANNSTRAIN WBFDWH: Unpublished observations. Google Scholar14. SOFFER LJ: Postarsphenamine jaundice, Am. Jr. Syph., Gonor., and Ven. Dis., 1937, xxi, 309. Google Scholar15. RICH AR: The pathogenesis of the forms of jaundice, Bull. Johns Hopkins Hosp., 1930, xlvii, 338. Google Scholar16. HANGERGUTMAN FMAB: Postarsphenamine jaundice apparently due to obstruction of intrahepatic biliary tract, Jr. Am. Med. Assoc., 1940, cxv, 263. CrossrefGoogle Scholar17. SALAMANKINGWILLIAMSNICOL MHAJDICS: Prevention of jaundice resulting from antisyphilitic treatment, Lancet, 1944, ii, 7. CrossrefGoogle Scholar18. SHEEHAN HL: Epidemiology of infective hepatitis, Lancet, 1944, ii, 8. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication October 31, 1944.From the Department of Medicine, The University of Rochester School of Medicine and Dentistry and the Medical Clinic of the Strong Memorial Hospital. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHemopoietic SystemDrug-Induced Haemolytic Reactions due to Antibodies Against the Erythrocyte/Dipyrone ComplexMetalleMetalleHematologyCurrent Concepts of Jaundice, with Particular Reference to Hepatitis 1 January 1946Volume 24, Issue 1Page: 104-111KeywordsAplastic anemiaBloodBone marrowDentistryDrugsHemolytic anemiaHemolytic jaundiceHospital medicine ePublished: 1 December 2008 Issue Published: 1 January 1946 PDF downloadLoading ...