tbuckley/cabot-search huggingface dataset:
Therapeutic Acupuncture in the People's Republic of China
Authors: John J. Bonica
Journal: JAMA (1974)

THE purposes of this report are to review the use of therapeutic acupuncture in the People's Republic of China, to summarize the current status of acupuncture in the United States, and to offer conclusions that hopefully will help the physician place this technique in proper perspective. This report is based on observations made during a three-week visit to the People's Republic of China, communication with other physicians who have visited China, my activities as Chairman of the Ad Hoc Committee on Acupuncture of the National Institutes of Health and the American Society of Anesthesiologists, and review of the literature. The three-week trip, made as a member of the American delegation, was organized by the Committee on Scholarly Communication with the People's Republic of China, at the invitation of the Chinese Medical Association. The 16-member delegation was headed by John R. Hogness MD, then president of the Institute of Medicine of
Sex selection before child's conception
Authors: P. Gunby
Journal: JAMA (1979)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nebraska prohibits abortion after 20 weeks because of fetal pain
Authors: J. H. Tanne
Journal: BMJ (2010)

The US state of Nebraska passed two laws restricting abortion last week. One law prohibits abortion after 20 weeks, because the fetus might feel pain. A second law requires doctors to examine women for mental or physical risks associated with abortion and ask whether they are voluntarily choosing an abortion 24 hours before the procedure is carried out.

The laws, which take effect on 15 October, will make it more difficult for women to have an abortion in Nebraska. The laws are likely to be challenged and may make their way to the US Supreme Court.

The midwestern state of Nebraska borders …
Corpulence and Correspondence
Authors: John G. Sotos
Journal: Annals of Internal Medicine (2014)

Letters15 April 2014Corpulence and CorrespondenceJohn G. Sotos, MDJohn G. Sotos, MDFrom University of North Carolina School of Medicine, Chapel Hill, North Carolina.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L14-5008 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITORLevine (1) makes several unreferenced statements at variance with my research into Taft's obstructive sleep apnea (2). Because Taft's papers comprise more than 700 000 lightly indexed documents, key documents can easily go unfound. I am hoping for clarification of 5 points.First, was Taft really 6 feet, 2 inches tall? He self-reports his height as 5 feet, 11.5 inches in an insurance application filed in 1900 (3).Second, Levine reports that Taft weighed 354 pounds in 1909 and 280 pounds at death. I uncovered no primary documentation for a weight more than “335 to 340 pounds” (4), ...References1. Levine DI. Corpulence and correspondence: President William H. Taft and the medical management of obesity. Ann Intern Med. 2013;159:565-70. [PMID: 24126649] LinkGoogle Scholar2. Sotos JG. Taft and Pickwick: sleep apnea in the White House. Chest. 2003;124:1133-42. [PMID: 12970047] CrossrefMedlineGoogle Scholar3. Taft WH. Insurance application. 1900. Located at: William Howard Taft National Historic Site, U.S. National Park Service. Google Scholar4. Taft WH. Letter from William Howard Taft to George Blumer. 18 May 1913. Located at: Library of Congress, William Howard Taft Papers, series 8, version 3, microfilm reel 518:403. Google Scholar5. Pringle HF. The Life and Times of William H. Taft. New York: Farrar & Rinehart; 1939:1072. Google Scholar6. Index to the William Howard Taft Papers. Washington, DC: US Gov Pr Office; 1972. Google Scholar Author, Article, and Disclosure InformationAuthors: John G. Sotos, MDAffiliations: From University of North Carolina School of Medicine, Chapel Hill, North Carolina.Disclosures: None. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L13-1151. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoCorpulence and Correspondence: President William H. Taft and the Medical Management of Obesity Deborah I. Levine Corpulence and Correspondence Deborah I. Levine Metrics 15 April 2014Volume 160, Issue 8Page: 580KeywordsDisclosureOverweightSleep apnea ePublished: 15 April 2014 Issue Published: 15 April 2014 Copyright & PermissionsCopyright © 2014 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Carrier Cell-based Delivery of an Oncolytic Virus Circumvents Antiviral Immunity
Authors: Anthony T Power, Jiahu Wang, Theresa J Falls, Jennifer M Paterson, Kelley A Parato, Brian D Lichty, David F Stojdl, Peter A J Forsyth, Harry Atkins, John C Bell
Journal: Molecular Therapy (2006)

Oncolytic viruses capable of tumor-selective replication and cytolysis have shown early promise as cancer therapeutics. However, the host immune system remains a significant obstacle to effective systemic administration of virus in a clinical setting. Here, we demonstrate the severe negative impact of the adaptive immune response on the systemic delivery of oncolytic vesicular stomatitis virus (VSV) in an immune-competent murine tumor model, an effect mediated primarily by the neutralization of injected virions by circulating antibodies. We show that this obstacle can be overcome by administering virus within carrier cells that conceal viral antigen during delivery. Infected cells were delivered to tumor beds and released virus to infect malignant cells while sparing normal tissues. Repeated administration of VSV in carrier cells to animals bearing metastatic tumors greatly improved therapeutic efficacy when compared with naked virion injection. Whole-body molecular imaging revealed that carrier cells derived from solid tumors accumulate primarily in the lungs following intravenous injection, whereas leukemic carriers disseminate extensively throughout the body. Furthermore, xenogeneic cells were equally effective at delivering virus as syngeneic cells. These findings emphasize the importance of establishing cell-based delivery platforms in order to maximize the efficacy of oncolytic therapeutics. Oncolytic viruses capable of tumor-selective replication and cytolysis have shown early promise as cancer therapeutics. However, the host immune system remains a significant obstacle to effective systemic administration of virus in a clinical setting. Here, we demonstrate the severe negative impact of the adaptive immune response on the systemic delivery of oncolytic vesicular stomatitis virus (VSV) in an immune-competent murine tumor model, an effect mediated primarily by the neutralization of injected virions by circulating antibodies. We show that this obstacle can be overcome by administering virus within carrier cells that conceal viral antigen during delivery. Infected cells were delivered to tumor beds and released virus to infect malignant cells while sparing normal tissues. Repeated administration of VSV in carrier cells to animals bearing metastatic tumors greatly improved therapeutic efficacy when compared with naked virion injection. Whole-body molecular imaging revealed that carrier cells derived from solid tumors accumulate primarily in the lungs following intravenous injection, whereas leukemic carriers disseminate extensively throughout the body. Furthermore, xenogeneic cells were equally effective at delivering virus as syngeneic cells. These findings emphasize the importance of establishing cell-based delivery platforms in order to maximize the efficacy of oncolytic therapeutics.
Crohn's disease in Norway 1956-63.
Authors: E Gjone, O M Orning, J Myren
Journal: Gut (1966)

EDITORIAL COMMENT The incidence of Crohn's disease in Norway has been studied for the eight-year period . A total of 73 cases of typical Crohn's disease was reported.The average annual rate per 1,000,000 population was 2-6 and the incidence during the period under review may have risen. Thre was no sex difference.The incidence was low in the youngest age groups.The rate did not vary with geographical area.The ratio for the incidence of ulcerative colitis to Crohn's disease for the period was 9-3:1.
Silica-shell cross-linked micelles encapsulating fluorescent conjugated polymers for targeted cellular imaging
Authors: Happy Tan, Yu Zhang, Miao Wang, Zhongxing Zhang, Xinhai Zhang, Anna Marie Yong, Siew Yee Wong, Alex Yuang-chi Chang, Zhi-Kuan Chen, Xu Li, Mahesh Choolani, John Wang
Journal: Biomaterials (2011)
Care of Evacuees From "Hurricane Betsy"
Authors: Dennis E. Weiland
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The 'Epidemiologic Necropsy'
Authors: Michael J. McFarlane
Journal: JAMA (1987)

When rising rates of occurrence are reported for a particular disease, clinicians often cannot determine whether the disease has increased in actual occurrence or in the improved detection provided by better diagnostic technology and expanded access to medical care. The epidemiologic use of necropsy data, which might help answer these questions, has been inhibited by fears of bias in demographic and clinical selection of patients for necropsy. The demographic problem can be managed by suitable adjustment and standardization of the disease rates found at necropsy, and the clinical problem can be reduced or avoided by studying the rates with which the disease is found unexpectedly in necropsies performed for other, unrelated clinical reasons. The results, obtained in population groups "screened" via necropsy, can suggest the magnitude of the "undetected reservoir" that coexists and supplements the rates of reported occurrence for a disease. In a study of necropsies at Yale—New Haven (Conn) Hospital from 1972 to 1981, the necropsy detection rates for lung cancer were slightly higher for women than for men, and were substantially higher for both genders than the customarily reported rates in the general population. The results suggest that the reported rates may continue to rise in both genders until they become essentially equal at a size approximating that of the currently undetected reservoir. The "epidemiologic necropsy" offers a potentially valuable method to help distinguish the true occurrence rates of disease from the changes attributable to improved diagnostic detection with modern technology. (<i>JAMA</i>1987;258:331-338)
Hair loss in a child associated with naproxen.
Authors: D. A. Barter
Journal: BMJ (1989)

shown abnormalities ranging from mild portal inflammation to centrizonal collapse with bridging.The course has been suggestive ofa hypersensitivity reaction with a shorter period to develop- ment ofabnormal liver function after re-exposure to the drug.Ours is the first case with typical pathological features of chronic active hepatitis.The evidence strongly implicated cimetidine.In- advertent re-exposure to the drug caused rapid recurrence of jaundice and abnormal liver function values, and withdrawal of cimetidine and treat- ment with prednisone for two months returned these values to normal, although repeat biopsy still showed evidence of chronic active hepatitis.Preexisting chronic active hepatitis exacerbated by cimetidine is unlikely in the absence of other recognised causes of chronic active hepatitis.This case adds to the slowly accumulating evidence implicating cimetidine as a rare but definite hepatotoxin.The low incidence makes monitoring of liver function values unlikely to be cost effective, but when clinical hepatitis occurs cimetidine must be considered a potential villain.
Case Number 28: Rheumatoid arthritis and congenitally short fourth metacarpals
Authors: J S Huntley
Journal: Annals of the Rheumatic Diseases (2003)

A 53 year old man had a long history of rheumatoid arthritis (RA) necessitating hip, knee and elbow replacements. Hand deformity and pain progressed (right worse), particularly at the metacarpophalangeal (MCP) joints. However, he had congenital short …
Measuring the Quality of Medical Care
Authors: David D. Rutstein, William Berenberg, Thomas C. Chalmers, Charles G. Child, Alfred P. Fishman, Edward B. Perrin, Jacob J. Feldman, Paul E. Leaverton, J. Michael Lane, David J. Sencer, Carleton C. Evans
Journal: New England Journal of Medicine (1976)

Abstract We outline the implementation of a new method of measuring the quality of medical care that counts cases of unnecessary disease and disability and unnecessary untimely deaths. First of all, conditions are listed in which the occurrence of a single case of disease or disability or a single untimely death would justify asking, "Why did it happen?" Secondly, we have selected conditions in which critical increases in rates of disease, disability, or untimely death could serve as indexes of the quality of care. Finally, broad categories of illness are noted in which redefinition and intensive study might reveal characteristics that could serve as indexes of health. We describe how these indexes of outcome can be used to determine the level of health of the general population and the effects of economic, political, and other environmental factors upon it, and to evaluate the quality of medical care provided both within and without the hospital to maintain health and to prevent and treat disease. (N Engl J Med 294:582–588, 1976)
Prognosis of Right Bundle-Branch Block in Acute Myocardial Infarction.
Authors: Lawrence A. Gould
Journal: Annals of Internal Medicine (1972)

Meeting Abstracts1 May 1972Prognosis of Right Bundle-Branch Block in Acute Myocardial Infarction.Lawrence A. Gould, M.D., F.A.C.P., K. Venkataraman, M.D., Robert F. Gomprecht, M.D., F.A.C.P.Lawrence A. Gould, M.D., F.A.C.P.Search for more papers by this author, K. Venkataraman, M.D.Search for more papers by this author, Robert F. Gomprecht, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-5-864_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRight bundle-branch block has recently been recognized as ominous in acute myocardial infarction. The records of 31 patients with RBBB and infarction were analyzed. Twenty-one were men and 10 were women. The average age was 66 years. The RBBB was present on admission ECG in 21 cases and subsequently appeared in 10 cases. Three patients had a transient RBBB. Fourteen patients presented with RBBB-left anterior hemiblock (LAH), 11 with RBBB-left posterior hemiblock (LPH), five with RBBB, and one with RBBB and prolonged PR interval. Ten of 14 patients (72%) with RBBB and LAH died of a cardiac arrhythmia within the... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Bronx, N.Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1972Volume 76, Issue 5Page: 864-864KeywordsAcute myocardial infarctionArrhythmiaInfarctionRight bundle branch block Issue Published: 1 May 1972 PDF DownloadLoading ...
Gas Exchange in Renal Failure: I--Dangers of Hyperkalaemia during Anaesthesia
Authors: M. J. Goggin, A. M. Joekes
Journal: BMJ (1971)

Failure to maintain compensatory hyperventilation during anaesthesia in patients with metabolic acidosis results in an increase in PaCO(2), fall in blood pH, and a possible rise in plasma potassium. This sequence of events may account for unexplained operative deaths in patients in renal failure.
OPTIC NEURITIS IN INFANTILE PARALYSIS
Authors: RALPH K. GHORMLEY
Journal: JAMA (1925)

In a recent case I noted a complication of infantile paralysis that seems worthy of consideration. Changes in the optic disk have been found in a great many of the acute infections,<sup>1</sup>such as meningitis, scarlet fever, typhoid, influenza and rheumatism, and they are also found in many neurologic conditions, but rarely have they been reported in infantile paralysis. <h3>REPORT OF CASE</h3><h3>History.</h3> —F. L., a youth, aged 18, white, student, a patient of Dr. C. R. Wylie of Pottstown, Pa., was taken ill rather suddenly, Oct. 11, 1922, with severe frontal headache. This persisted three days, when he was sent to the school infirmary. The temperature reached 103.4 F. on the third day and dropped to normal on the sixth day. After he had been at the infirmary three days, during which time the headache persisted together with some nausea and vomiting, the patient began to show loss
Prospective Evaluation of Ki&amp;ndash;67 Labeling in Predicting the Recurrence and Progression of Superficial Bladder Transitional Cell Carcinoma
Authors: Pascal Blanchet, St&eacute;phane Droupy, Pascal Eschwege, Annick Viellefond, Valerie Paradis, Marie-France Pichon, Alain Jardin, G&eacute;rard Benoit
Journal: European Urology (2001)
Rapid infusion rituximab in combination with corticosteroid-containing chemotherapy or as maintenance therapy is well tolerated and can safely be delivered in the community setting
Authors: Laurie H. Sehn, Jane Donaldson, Allison Filewich, Catherine Fitzgerald, Karamjit K. Gill, Nancy Runzer, Barb Searle, Sheila Souliere, John J. Spinelli, Judy Sutherland, Joseph M. Connors
Journal: Blood (2007)
Significance of Hematoxylin Bodies in Lupus Erythematosus Cell Preparations
Authors: J. D. Arterberry, E. Drexler, E. L. Dubois
Journal: JAMA (1964)

Review of 14,000 lupus erythematosus (LE) tests performed on 3,000 patients showed that extracellular hematoxylin bodies occurred at least once in negative LE tests on 358 patients. Homogeneous round hematoxylin bodies occurred in one control and 258 patients, mostly those with rheumatic disorders. They resembled LE cell inclusion bodies except for their extracellular location, occurring in 116 (23%) of 502 patients with proved SLE including 33 (6.6%) who never showed LE cells. Of the 258 patients, 45% had proved SLE, 46% had variants of SLE or rheumatoid arthritis, 5% had alcoholic cirrhosis or myeloma, while 4% remained unclassified or incompletely studied. The rotary LE method enhanced hematoxylin body formation. Phase contrast microscopy suggested that some LE negative sera from proved SLE patients formed LE-like cells which apparently disintegrated during fixation and staining to yield only hematoxylin bodies.
Technical-Skills Training in the 21st Century
Authors: Rajesh Aggarwal, Ara Darzi
Journal: New England Journal of Medicine (2006)

Medical education is undergoing a paradigm shift, from the traditional experience-based model to a program that requires documentation of proficiency.1 Technological advances in health care, the development of day-case surgery, and the setting of quality-assurance targets have led to a striking reduction in training opportunities for young doctors. It is no longer acceptable, or appropriate, for students at any level of training to practice new skills on patients, even if they have a patient's explicit consent.As Reznick and MacRae point out in this issue of the Journal, these “changes in the wind” are beginning to transform surgical residency programs. . . .
Unpredictable Survival In Coronary Artery Disease
Authors: Harold Feil
Journal: JAMA (1966)

To the Editor:—  In a recent editorial ( 195 :860, 1966), Elusive Errors in Coronary Statistics are emphasized. I am in hearty agreement with the thesis, but I would like to emphasize the unpredictability of survival in the individual case of coronary artery disease. The survival period after the onset of angina or the development of infarction is from 0 to 30 or 40 years. Modifying factors such as shock, arrhythmias, heart failure, persistence of pain, diabetes, or generalized arteriosclerosis, help in arriving at a tentative prognosis. If the patient survives the initial illness he has a fairly definite chance of surviving from year to year and the longer is the more likely subsequent course. In fact in a recent personal study of 1,516 cases of infarction, the survival rate of patients who recovered from the first infarction was 90% for the first year and in subsequent years it was 85%
THE ABSORPTION OF STROPHANTHIN FOLLOWING SUBLINGUAL AND PERLINGUAL ADMINISTRATION
Authors: CARY EGGLESTON
Journal: JAMA (1927)

The therapeutic use of strophanthin<sup>1</sup>is at present limited almost exclusively to its intramuscular or intravenous injection as an emergency cardiac stimulant. This is partly because of the well established fact that strophanthin is absorbed from the stomach and intestinal tract so inadequately as well as so irregularly that its oral administration is both unsafe and therapeutically unsatisfactory, although some continue to employ it or the tincture of strophanthus in this manner. Neither intramuscular nor intravenous injection is suitable for frequent repetition over the more or less prolonged periods generally required in the treatment of cardiac failure. Therefore the suggestions that strophanthin could be administered beneath the tongue, or in alcoholic solution applied to the dorsum of the tongue, with reasonable certainty of effective absorption and satisfactory therapeutic action were deemed of sufficient interest to warrant their further investigation. <h3>SUBLINGUAL ADMINISTRATION</h3> The literature is very meager but is such