Ginseng and Warfarin Interactions
Authors: Gregory A. Plotnikoff, Dennis McKenna, Kenji Watanabe, Mark Blumenthal
Journal: Annals of Internal Medicine (2004)

Letters7 December 2004Ginseng and Warfarin InteractionsGregory A. Plotnikoff, MD, MTS, Dennis McKenna, PhD, Kenji Watanabe, MD, PhD, and Mark Blumenthal, BAGregory A. Plotnikoff, MD, MTSFrom University of Minnesota Medical School, Minneapolis, MN 55455; Keio University Medical School, Tokyo 160-8582, Japan; and American Botanical Council, Austin, TX 78723.Search for more papers by this author, Dennis McKenna, PhDFrom University of Minnesota Medical School, Minneapolis, MN 55455; Keio University Medical School, Tokyo 160-8582, Japan; and American Botanical Council, Austin, TX 78723.Search for more papers by this author, Kenji Watanabe, MD, PhDFrom University of Minnesota Medical School, Minneapolis, MN 55455; Keio University Medical School, Tokyo 160-8582, Japan; and American Botanical Council, Austin, TX 78723.Search for more papers by this author, and Mark Blumenthal, BAFrom University of Minnesota Medical School, Minneapolis, MN 55455; Keio University Medical School, Tokyo 160-8582, Japan; and American Botanical Council, Austin, TX 78723.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-141-11-200412070-00030 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Yuan and colleagues' Brief Communication (1) provides an important opportunity to recognize 2 caveats when interpreting the significance of botanical medicine research.First, terms such as ginseng may actually represent many species. For example, North American ginseng (Panax quinquefolius L.) is just one type of commercially available ginseng. From a scientific point of view, data from a study of P. quinquefolius are not applicable to other commercially available Panax species that may also go by the general name ginseng. These include P. ginseng CA Meyer (Asian ginseng,) P. japonicus CA Meyer (Japanese ginseng), P. pseudoginseng Wallich (Himalayan ...References1. Yuan CS, Wei G, Dey L, Karrison T, Nahlik L, Maleckar S, et al. Brief communication: American ginseng reduces warfarin's effect in healthy patients: a randomized, controlled trial. Ann Intern Med. 2004;141:23-7. [PMID: 15238367] LinkGoogle Scholar2. Assinewe VA, Baum BR, Gagnon D, Arnason JT. Phytochemistry of Wild Populations of Panax quinquefolius L. (North American Ginseng). J Agric Food Chem. 2003;51:4549-53. [PMID: 14705875] CrossrefMedlineGoogle Scholar3. Shibata S, Tanaka O, Shoji I, Saito H. Chemistry and Pharmacology of Panax.. In: Wagner H, Hikino H, Farnsworth NR, eds. Economic and Medicinal Plant Research. vol 1. New York: Academic Pr; 1985:217-84. Google Scholar4. Awang DVC. The neglected ginsenosides of North American Ginseng. Journal of Herbs Spices and Medicinal Plants. 2000;7:103-9. CrossrefGoogle Scholar5. Asafu-Adjaye EB, Wong SK. Determination of ginsenosides (ginseng saponins) in dry root powder from Panax ginseng, Panax quinquefolius, and selected commercial products by liquid chromatography: interlaboratory study. J AOAC Int. 2003;86:1112-23. [PMID: 14979691] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Gregory A. Plotnikoff, MD, MTS; Dennis McKenna, PhD; Kenji Watanabe, MD, PhD; Mark Blumenthal, BAAffiliations: From University of Minnesota Medical School, Minneapolis, MN 55455; Keio University Medical School, Tokyo 160-8582, Japan; and American Botanical Council, Austin, TX 78723. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoBrief Communication: American Ginseng Reduces Warfarin's Effect in Healthy Patients Chun-Su Yuan , Gang Wei , Lucy Dey , Theodore Karrison , Linda Nahlik , Spring Maleckar , Kristen Kasza , Michael Ang-Lee , and Jonathan Moss Ginseng and Warfarin Interactions Chun-Su Yuan Metrics Cited byReview on mechanisms and interactions in concomitant use of herbs and warfarin therapyPhytochemical Informatics of Traditional Chinese Medicine and Therapeutic RelevanceInfrared-based protocol for the identification and categorization of ginseng and its productsAuthentication of traditional Chinese medicine using infrared spectroscopy: distinguishing between ginseng and its morphological fakes 7 December 2004Volume 141, Issue 11 Page: 893-894 Keywords Attention Chromatography Glycosides ePublished: 7 December 2004 Issue Published: 7 December 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...