tbuckley/cabot-search huggingface dataset:
A New Provocative Test for Pheochromocytoma.
Authors: Ann M. Lawrence
Journal: Annals of Internal Medicine (1965)

s1 November 1965A New Provocative Test for Pheochromocytoma.Ann M. Lawrence, M.D.Ann M. Lawrence, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-5-905_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptGlucagon has provoked striking blood pressure elevations in two patients with documented pheochromocytoma (180/100 mm Hg to 260/140 mm Hg, and 140/90 mm Hg to 300/160 mm Hg) and in one suspected case (140/70 mm Hg to 300/ 180 mm Hg) under study. Peak rise occurred 30 to 60 seconds after rapid intravenous injection of 0.5 to 1 mg glucagon. When Regitine⌖ was administered there was prompt return of blood pressure to normal.Intravenous glucagon produced no significant blood pressure rise when administered to 26 control subjects, including healthy individuals and patients with essential hypertension, thyrotoxicosis, diabetes mellitus, and acromegaly.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, Illinois PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByContrast media for fluoroscopic examinations of the GI and GU tracts: current challenges and recommendationsFrom plant physiology to human metabolic investigationsGlucagon and CatecholaminesHypertension in ChildhoodGlucagon and PheochromocytomaA. M. LAWRENCE, M.D., PH.D.GlucagonHypotheses actuelles concernant le role physiologique du glucagonInterrelationships Glucagon-Adrenergic System in Man Interest for the Diagnosis of PheochromocytomaInterrelationships Glucagon-Adrenergic System in ManGlucagon Provocative Test for PheochromocytomaA. M. LAWRENCE, M.D., PH.D.SECONDARY SEX CHARACTERISTICS ?URINARY INFECTION IN THE TWO SEXESGLUCAGON TEST FOR PHÆOCHROMOCYTOMAAcute Pheochromocytoma 1 November 1965Volume 63, Issue 5Page: 905-906KeywordsAcromegalyBlood pressureDiabetes mellitusGlucagonHypertensionIntravenous injectionsPheochromocytoma Issue Published: 1 November 1965 PDF DownloadLoading ...
415 ORAL SUPPLEMENTATION WITH BRANCHED-CHAIN AMINO ACIDS (BCAA) IMPROVES SURVIVIAL AND DECREASES THE THIRD TIME RECURRNCE AFTER SUCCESSFUL TREATMENT OF HEPATOCELLULAR CARCINOMA (HCC)
Authors: K. Tsuchiya, Y. Asahina, M. Sato, T. Tanaka, I. Hirayama, Y. Yasui, N. Komatsu, N. Umeda, T. Hosokawa, K. Ueda, H. Nakanishi, J. Itakura, M. Kurosaki, I. Namiki
Journal: Journal of Hepatology (2008)
A Comparison of the Direct Effects and Adrenergic Blocking Activity of D/L- and D-propranolol on the Electrical and Mechanical Behaviour of Isolated Frog Ventricle
Authors: D. W. Pollen, A. C. Scott, W. F. M. Wallace
Journal: Cardiovascular Research (1969)

Propranolol was found to reduce the rate of depolarization, amplitude, and duration of the action potential recorded from frog ventricular myocardium. In these respects, D-propranolol was of similar potency to D/L-propranolol. However, D/L-propranolol was much more effective than the dextro isomer in blocking the increase in rate of depolarization, amplitude, and duration of the action potential caused by adrenaline; it was also much more potent than the dextro isomer in blocking the inotropic response to adrenaline.
[K+]o-dependent change in conformation of the HERG1 long QT mutation N629D channel results in partial reversal of the in vitro disease phenotype
Authors: Guo Qi Teng, James P Lees-Miller, Yanjun Duan, Bao-Tsen Li, Pin Li, Henry J Duff
Journal: Cardiovascular Research (2003)

Objectives: We hypothesized that exposure of N629D/wildtype channels to transient increases in [K+]o could alter the conformation of the outer vestibule and thus reverse the disease phenotype. N629D is a recently described mutation of the HERG1 gene that causes familial long QT syndrome. This mutation alters the pore signature sequence resulting in loss of K+ selectivity. Previous studies have reported that enforced occupancy of [K+]o at sites near the selectivity filter alters the conformation/folding of the outer vestibule of the Kv2.1 channel. Methods: Since the long QT syndrome is manifest in individuals who are heterozygous for this HERG trait, we co-expressed N629D and the wildtype at equimolar concentrations. Results: Co-expression of N629D/wildtype in Xenopus oocytes and mammalian cells resulted in a channel with a positive shift in reversal potential and a loss in the outward tail current, relative to the wildtype. Exposure of the N629D/wildtype to transient increases in [K+]o from 5 to 40 mM/l changed the tail current from inward to outward during repolarization and restored the reversal potential to values similar to the wildtype. These findings in Xenopus oocytes were also seen when N620D/wildtype channels were expressed in mammalian cells. These [K+]o-dependent changes persisted for hours after the [K+]o was returned to 2.5 mM. This potential therapeutic effect began with increases in [K+]o from 2.5 to 5 mM. Conclusions: This study reports a novel therapeutic strategy and mechanism to partially restore physiologic function in this HERG LQTS mutation.
"Silent" adrenal tumours should be monitored for changes, say researchers
Authors: Z. Kmietowicz
Journal: BMJ (2014)

“Silent” adrenal tumours can change over time to become more active, increasing the amount of cortisol that they secrete and elevating cardiovascular risk in patients, a study has found.

The increasing use of computed tomography (CT) in medicine has led to a rise in the detection of masses on the adrenal gland that do not cause symptoms—known as “silent” tumours or adrenal incidentalomas. About 4% of CT scans now uncover such tumours in patients, and as many as a third of these …
URETERAL INJECTION OF OIL FOLLOWED BY THE SPONTANEOUS PASSING OF A URETERAL STONE.
Authors: LOUIS E. SCHMIDT
Journal: JAMA (1904)

Mrs. P., age 35 years, married 10 years. Family and previout history gives no information. Present sickness commenced in June, 1897, with a sudden colicky pain in the right iliac region and lancinating pains down the inner surface of the right thigh. This attack lasted 20 hours, and during this period Dr. Etheridge found a copious quantity of blood in the urine, and was obliged to give morphin hypodermatically to alleviate the pain. Since then the patient has had repeated typical attacks of renal colic; however, the pain was more or less localized in the right iliac region, and the attacks were never as severe as the first. A skiagraph taken in December, 1902, showed the outlines of a ureteral stone. The dull ache and tenderness always corresponded to this point. Drs. Harvey and Paddock referred the case to me Jan. 5, 1904. I catheterized the right ureter and several
BIOCHEMICAL STUDY OF MUSCLE IN PROGRESSIVE MUSCULAR DYSTROPHY 1
Authors: Jean-Claude Dreyfus, Georges Schapira, Fanny Schapira
Journal: Journal of Clinical Investigation (1954)

Current concepts of progressive muscular dystrophy hold that it is a disease in which, through genetic error, there are intrinsic defects in muscle metabolism, although the nature of these hypothetical defects remains unrecognized. It is the purpose of this report to describe one approach to the problem and to show that there are defects in the metabolism of isolated muscle from patients with progressive muscular dystrophy.
Determinants of prognosis in symptomatic ventricular tachycardia or ventricular fibrillation late after myocardial infarction
Authors: Albert R. Willems, Jan G.P. Tijssen, Frans J.L. van Capelle, J.Herre Kingma, Richard N.W. Hauer, Freddy E.E. Vermeulen, Pedro Brugada, Diederick C.A. van Hoogenhuyze, Michiel J. Janse
Journal: Journal of the American College of Cardiology (1990)
Surgical Correction of Mitral Insufficiency Due to Ruptured Chordae Tendineae
Authors: FRANK GERBODE, J. DONALD HILL, JOHN J. KELLY, ARTHUR SELZER, WILLIAM J. KERTH
Journal: Circulation (1968)

During the past six years we have operated on 80 patients with predominant mitral insufficiency. Twenty-two patients had ruptured chordae tendineae. Rheumatic heart disease was frequently the cause when there was considerable valve deformity and ruptured chordae to the anterior mitral leaflet. The etiology of these cases was rheumatic heart disease in only 2 of the 15 patients with ruptured chordae to the posterior leaflet. In eight the etiology was unknown. These cases had a syndrome in which there is an aortic as well as an apical systolic murmur. The left atrium was frequently not so large as in rheumatic mitral insufficiency, and most patients were in sinus rhythm. Because of a relative excess of reserve tissue of the posterior leaflet, localized rupture of chordae to this leaflet can easily be corrected by a simple plication procedure.
Opening doors to research resources, facilities, skills
Authors: Marsha F. Goldsmith
Journal: JAMA (1984)

The Division of Research Resources (DRR) has the multifaceted role of providing access to clinical research facilities, funding animal research facilities and resources, supporting technical equipment for biomedical scientists, and encouraging members of minority groups to undertake careers in biomedical research. In so doing, says Director Betty H. Pickett, PhD, the division is undergirding much of the biomedical research effort funded by the National Institutes of Health.  In contrast to other NIH components that received an overall budget increase of 11% in 1984, the division received a 13% increase. This was partially  of the cost of the advanced research instrumentation— for which $20 million was appropriated this year— that it supplies on a shared basis to its grantees.  I think our Shared Instrumentation Grant Program is a very important challenge, Pickett says, because a surprising amount of scientific equipment in this country is obsolete.  Meeting this and other challenges
83 DNP73 IS A DIRECT TARGET GENE OF BOTH GAIN-OF-FUNCTION BETA-CATENIN MUTANTS AND WILD-TYPE DEREGULATED BETA-CATENIN AND COUPLES WNT PATHWAY ACTIVATION TO CHEMIORESISTANCE IN HUMAN HCC
Authors: V. Schinzari, E. Palescandolo, S. Vossio, B. Testoni, R. De iaco, M. Levrero
Journal: Journal of Hepatology (2008)
Temporal trends of organochlorine concentrations in umbilical cord blood of newborns from the lower north shore of the St. Lawrence river (Québec, Canada).
Authors: Frédéric Dallaire, Eric Dewailly, Claire Laliberté, Gina Muckle, Pierre Ayotte
Journal: Environmental Health Perspectives (2002)

This study describes the time trends of organochlorines [OCs; 14 polychlorinated biphenyls (PCBs) and 11 chlorinated pesticides] in umbilical cord plasma of newborns in a remote Canadian coastal population. We analyzed 408 cord blood samples collected between 1993 and 2000 for PCBs, chlordanes, dichlorodiphenyltrichloroethane (DDT), dichlorodiphenyltrichloroethylene (DDE), hexachlorobenzene (HCB), and n-3 fatty acids. We also gathered information on the mothers (age, past and present residence, ethnic group, use of tobacco during pregnancy, and breast-feeding during previous pregnancies). From 1993 to 2000, mean concentrations of PCBs, chlordanes, DDT/DDE, and HCB in cord blood decreased by 63%, 25%, 66%, and 69%, respectively (p &lt; 0.0001). Multiple regression analysis with the year of birth as the main independent variable yielded a strong significant exponential decrease for all contaminants (in all age and ethnic groups). We detected no monthly or seasonal pattern. We used n-3 fatty acids concentration as a surrogate of maternal fish consumption. Fish consumption declined only slightly between 1993 and 2000, but this decrease did not contribute significantly to the reduction of OCs. These results show that prenatal exposure to persistent OCs has declined significantly between 1993 and 2000 in this population.
A SPECIFIC PRECIPITIN REACTION IN EPIDEMIC POLIOMYELITIS
Authors: EDWARD C. ROSENOW
Journal: JAMA (1925)

The hypothesis that a streptococcus having peculiar neurotropic and other properties might have etiologic relationship to epidemic poliomyelitis was formulated on the basis of certain extremely specific effects noted during my studies on focal infection and elective localization in other diseases. In 1916, I first demonstrated the presence of a streptococcus having peculiar neurotropic properties in infection atria and brain and cord in a series of cases of poliomyelitis. It has since been demonstrated consistently in sporadic cases, and in a large number of cases in various epidemics. Through agglutination tests and intracerebral inoculation of rabbits with dilute suspensions of swabbings from the nasopharynx, I demonstrated its presence during the epidemic of poliomyelitis that occurred in and about Rochester in 1921, not only in persons suffering from severe and abortive attacks, but also in normal contacts and in persons not exposed to the disease. Moreover, it was proved absent one
CLINICAL EXPERIENCE WITH STREPTOKINASE AND STREPTODORNASE IN TUBERCULOSIS
Authors: Joseph M. Miller
Journal: JAMA (1952)

Streptokinase and streptodornase are useful topical adjuncts in the surgical treatment of certain acute and chronic diseases. The properties of these compounds and the results of treatment have been reported in detail elsewhere.<sup>1</sup>Streptokinase is a catalytic agent acting on a fibrin-lysing system present in the euglobulin fraction of human blood. The agent activates the fibrin-lysing system, which causes liquefaction of fibrin. Streptokinase also inhibits the change of fibrinogen to fibrin. Tests of streptokinase for protein give positive results. The substance is rendered inert by trypsin and activated papain, does not act upon casein, peptone, or gelatin, and can be isolated from the dissolved fibrin clot after completion of liquefaction. Streptokinase is antigenic, and an antikinase may develop in human beings as the result of antecedent hemolytic streptococcic infection or prolonged treatment with streptokinase. Streptodornase is an enzyme having the capacity to hydrolyze desoxyribose nucleoprotein. Kunitz<sup>2</sup>has described
A Recurrent Activating <i>PLCG1</i> Mutation in Cardiac Angiosarcomas Increases Apoptosis Resistance and Invasiveness of Endothelial Cells
Authors: Kristin Kunze, Tilmann Spieker, Ulrike Gamerdinger, Kerstin Nau, Johannes Berger, Thomas Dreyer, Jürgen R. Sindermann, Andreas Hoffmeier, Stefan Gattenlöhner, Andreas Bräuninger
Journal: Cancer Research (2014)

Primary cardiac angiosarcomas are rare tumors with unfavorable prognosis. Pathogenic driver mutations are largely unknown. We therefore analyzed a collection of cases for genomic aberrations using SNP arrays and targeted next-generation sequencing (tNGS) of oncogenes and tumor-suppressor genes. Recurrent gains of chromosome 1q and a small region of chromosome 4 encompassing KDR and KIT were identified by SNP array analysis. Repeatedly mutated genes identified by tNGS were KDR with different nonsynonymous mutations, MLL2 with different nonsense mutations, and PLCG1 with a recurrent nonsynonymous mutation (R707Q) in the highly conserved autoinhibitory SH2 domain in three of 10 cases. PLCγ1 is usually activated by Y783 phosphorylation and activates protein kinase C and Ca(2+)-dependent second messengers, with effects on cellular proliferation, migration, and invasiveness. Ectopic expression of the PLCγ1-R707Q mutant in endothelial cells revealed reduced PLCγ1-Y783 phosphorylation with concomitant increased c-RAF/MEK/ERK1/2 phosphorylation, increased IP3 amounts, and increased Ca(2+)-dependent calcineurin activation compared with ectopic expressed PLCγ1-wild-type. Furthermore, cofilin, whose activation is associated with actin skeleton reorganization, showed decreased phosphorylation, and thus activation after expression of PLCγ1-R707Q compared with PLCγ1-wild-type. At the cellular level, expression of PLCγ1-R707Q in endothelial cells had no influence on proliferation rate, but increased apoptosis resistance and migration and invasiveness in in vitro assays. Together, these findings indicate that the PLCγ1-R707Q mutation causes constitutive activation of PLCγ1 and may represent an alternative way of activation of KDR/PLCγ1 signaling besides KDR activation in angiosarcomas, with implications for VEGF/KDR targeted therapies.
Recurrent Positive Selection at Bgcn, a Key Determinant of Germ Line Differentiation, Does Not Appear to be Driven by Simple Coevolution with Its Partner Protein Bam
Authors: Vanessa L. Bauer DuMont, Heather A. Flores, Mark H. Wright, Charles F. Aquadro
Journal: Molecular Biology and Evolution (2006)

Surveys of nucleotide sequence polymorphism in Drosophila melanogaster and Drosophila simulans were performed at 2 interacting loci crucial for gametogenesis: bag-of-marbles (bam) and benign gonial cell neoplasm (bgcn). At the polymorphism level, both loci appear to be evolving under the expectations of the neutral theory. However, ratios of polymorphism and divergence for synonymous and nonsynonymous mutations depart significantly from neutral expectations for both loci consistent with a previous observation of positive selection at bam. The deviations suggest either an excess of synonymous polymorphisms or an excess of nonsynonymous fixations at both loci. Synonymous evolution appears to conform to neutrality at bam. At bgcn, there is evidence of positive selection affecting preferred synonymous mutations along the D. simulans lineage. However, there is also a significantly higher rate of nonsynonymous fixations at bgcn within D. simulans. Thus, the deviation from neutrality detected by the McDonald-Kreitman test at these 2 loci is likely due to the selective acceleration of nonsynonymous fixations. Differences in the pattern of amino acid fixations between these 2 interacting proteins suggest that the detected positive selection is not due to a simple model of coevolution.
Pheochromocytoma and Hyperparathyroidism
Authors: R. Bouillon, P. De Moor, C. Nagant De Deuxchaines
Journal: Annals of Internal Medicine (1974)

Comments1 July 1974Pheochromocytoma and HyperparathyroidismR. BOUILLON, P. DE MOOR, C. NAGANT DE DEUXCHAINESR. BOUILLONSearch for more papers by this author, P. DE MOORSearch for more papers by this author, C. NAGANT DE DEUXCHAINESSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-81-1-131_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The report of Kukreja and colleagues (1) clarifies the possible influence of catecholamines on the secretion of parathyroid hormone. We therefore wish to report a similar case, in Patient A, of pheochromocytoma and temporary hyperparathyroidism. Although the serum calcium level was normal before operation, a disodium ethylenediaminetetraacetate test (50 mg/kg body weight intravenously over 2 hours) was performed as part of a preoperative exploration for pluriglandular involvement. Increased serum parathyroid hormone levels were found; after surgical removal of the pheochromocytoma the same test was repeated and gave normal results (Table 1). But in a second patient with...References1. KUKREJAHARGISROSENTHAL SGI: Pheochromocytoma causing excessive parathyroid hormone production and hypercalcemia. Ann Intern Med 79:838-840, 1973 LinkGoogle Scholar2. FISCHERBLUMBINSWANGER JJU: Acute parathyroid hormone response to epinephrine in vivo. J Clin Invest 52:2434-2440, 1973 CrossrefMedlineGoogle Scholar3. SIPPLE J: The association of pheochromocytoma with carcinoma of the thyroid gland. Am J Med 31:163-166, 1961 CrossrefGoogle Scholar4. BOUILLONDE MOOR RP: Pathophysiological data obtained with a radioimmunoassay for human parathyroid hormone. Ann Endocrinol (Paris) 34:657-667, 1973 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Hôpital Universitaire St. Pierre Louvain, Belgium PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHormonal Modifiers of Mineral Metabolism Other Than Parathyroid Hormone, Vitamin D, and CalcitoninMultiple Paragangliomata Secreting Catecholamines and Calcitonin with Intermittent HypercalcaemiaPhaeochromocytoma and hypercalcaemia 1 July 1974Volume 81, Issue 1Page: 131-131KeywordsBody weightCalciumCatecholaminesHyperparathyroidismParathyroid hormonePheochromocytoma Issue Published: 1 July 1974 PDF downloadLoading ...
Effect of intranasal azelastine and beclomethasone dipropionate on nasal symptoms, nasal cytology, and bronchial responsiveness to methacholine in allergic rhinitis in response to grass pollens
Authors: Andrea Pelucchi, Anita Chiapparino, Berardino Mastropasqua, Luigi Marazzini, Alicia Hernandez, Antonio Foresi
Journal: Journal of Allergy and Clinical Immunology (1995)
Preventing the Heterosexual Spread of AIDS
Authors: Kevin Schulman
Journal: JAMA (1988)

<h3>To the Editor.—</h3> The conclusion reached by Drs Hearst and Hulley<sup>1</sup>that prevention of acquired immunodeficiency syndrome (AIDS) can be accomplished by ensuring that sexual partners are at low risk of human immunodeficiency virus (HIV) infection is consistent with their experience with infected individuals in San Francisco. However, the experience in New York City is very different. One of the first AIDS patients I treated was married to her second husband. After being delivered of three seronegative children during her first marriage, her child from this second marriage was seropositive. On investigation, her second husband was found to be a former intravenous drug abuser who had stopped using drugs before the couple met. Even with the intimacy of marriage and childbirth, the wife had never ascertained that her husband was at high risk of HIV infection. In socioeconomically disadvantaged areas of New York, high-risk partners are virtually indistinguishable from
Trends in suicide in Scotland 1974-84: an increasing problem.
Authors: P McLoone, I K Crombie
Journal: BMJ (1987)

A detailed investigation of trends in suicide rates in Scotland from 1974 to 1984 showed a complex pattern. Overall rates for men increased by 40% with the greatest increases in those aged 45-64. In contrast, rates for women showed a small decline, which was most noticeable in those aged 15-24. The well recognised decline in poisoning by domestic gas was seen over this period, and suicide by this method virtually stopped. Both sexes showed a decline in suicide by poisoning with drugs, although the decrease was larger among women. The fall in suicide rates among young women was almost all due to the decrease in this method. The rise in rates for men was largely due to increases in hanging and poisoning with vehicle exhaust gases, although all methods except drugs and domestic gas showed some increase. These findings indicate that suicide is an increasing problem with causes that are far from understood, so that prevention may be difficult.
Environmental tobacco smoke and measures of subclinical vascular disease.
Authors: G Howard, L E Wagenknecht
Journal: Environmental Health Perspectives (1999)

Assessing the relationship of exposure to environmental tobacco smoke (ETS) with subclinical measures of atherosclerotic disease supplements the epidemiologic data on fatal and nonfatal cardiovascular events. In addition, such assessment offers the opportunity to study smaller populations (including subgroups within larger studies) through improved statistical precision relative to the analysis of the relationship of ETS and clinical events and provides insights into the mechanisms of the harmful effects of ETS. In this article we review the published literature on the relationship of ETS with several indices of subclinical atherosclerosis including carotid artery intimal-medial thickness, brachial artery endothelial functioning, and silent cerebral infarctions. In each of these domains, exposure to ETS is associated with evidence of increased subclinical vascular disease.