tbuckley/cabot-search huggingface dataset:
Spectrum of subepidermal immunobullous disorders seen at the National Skin Centre, Singapore: a 2-year review
Authors: S.N. Wong, S.H. Chua
Journal: British Journal of Dermatology (2002)

The subepidermal immunobullous disorders (SEIBDs) comprise bullous pemphigoid (BP), cicatricial pemphigoid (CP), epidermolysis bullosa acquisita (EBA), linear IgA disease (LAD), dermatitis herpetiformis (DH), pemphigoid gestationis (PG) and bullous systemic lupus erythematosus (BSLE). They are thought to be rarer in the Far East than in western Europe.This 2-year retrospective study investigates the spectrum seen at our centre and the minimum estimated incidence of each.A total of 67 patients seen at the National Skin Centre (NSC), Singapore between January 1998 and December 1999 were diagnosed as having an SEIBD. Fifty-nine (88%) had BP, four (6%) had EBA, two (3%) LAD and two (3%) BSLE. There were no cases of CP, DH or PG diagnosed during this period. The minimum estimated incidence in our local population was 7.6, 0.5, 0.26 and 0.26 per million population per year, respectively. The mean age of onset was 77, 68, 65 and 31 years, respectively.BP is the commonest SEIBD seen locally, with an incidence at least equal to that in western Europe. It is diagnosed at our centre three times more frequently than pemphigus. There is a predilection for ethnic Chinese but not Indian. EBA is twice as common as in western Europe and shows a predilection for ethnic Indians. LAD is rare here compared to China, despite the predominant Chinese population. BSLE is also rare. In contrast to western Europe, CP, DH and PG are very rare in Singapore.This is the first study from this region to show that certain SEIBDs are not rarer in the Far East, as previously thought.
Prolonged transgene expression in murine salivary glands following non-primate lentiviral vector transduction
Authors: Ela Shai, Aaron Palmon, Amos Panet, Yitzhak Marmary, Yoav Sherman, Michael A. Curran, Eithan Galun, Reba Condiotti
Journal: Molecular Therapy (2005)

Salivary glands are an accessible organ for gene therapy, enabling expression of recombinant proteins for both exocrine and endocrine secretion. Lentivirus-based vectors have many advantages for gene therapy, including their ability to infect nondividing cells and to stably integrate into the host genome, enabling long-term transgene expression without eliciting an inflammatory immune response. In the present study, murine salivary glands were inoculated with feline immunodeficiency virus (FIV)-based lentiviral vectors expressing various reporter genes. Luciferase expression was observed as early as 24 h posttransduction, peaked at 17-21 days, and remained stable for more than 80 days. Staining with X-gal suggested that mucous acinar cells were effectively transduced. FIV vector transduction with the secreted alkaline phosphatase gene increased serum levels in treated animals for up to 45 days, and the FIV vector harboring the interferon-gamma (IFN-gamma) expression cassette induced an increase in IFN-gamma serum levels as well as in the supernatant of salivary gland explant cultures. These results demonstrate that the transduction of salivary glands with nonprimate lentiviral vectors may provide a novel and highly effective vehicle for long-term endocrine transgene expression.
Mir-194 is a hepatocyte gate keeper hindering HCV entry through targeting CD81 receptor
Authors: Radwa Yehia Mekky, Nada Magdy El-Ekiaby, Mohammed Tarif Hamza, Noha Mousaad Elemam, Mohammed EL-sayed, Gamal Esmat, Ahmed Ihab Abdelaziz
Journal: Journal of Infection (2014)
Holy Man and his disease
Authors: R. H. Moser
Journal: JAMA (1974)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Estrogen and Alzheimer Disease
Authors: Bennett A. Shaywitz, Sally E. Shaywitz
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An Investigator's Journey in Cardiology
Authors: Richard J. Bing
Journal: JAMA (1992)

SUMMING up 60 years in academic medicine, in hospital wards, and in research laboratories is a difficult task: memories and impressions converge and the resonance from past events continually changes. How is one to judge one's past? Many would rate it by honors received, societies elected to, or fortune amassed. I judge my life by the degree of happiness I have received from my work, from my music, and from my family. I have been fortunate in having all my life done what I love most: pursuing the science of medicine and creating music. These have formed the anchor that has given my life stability and a continuous sense of value. <h3>Student Years in Europe</h3> From the beginning of medical school I was interested in science and felt that the purely clinical side was only half the coin, for without a strong emphasis on science, medicine would become stagnant. But
The Ethics of Personal Stockpiles
Authors: John G. Bartlett, Frederick G. Hayden
Journal: Annals of Internal Medicine (2006)

Letters21 February 2006The Ethics of Personal StockpilesJohn G. Bartlett, MD and Frederick G. Hayden, MDJohn G. Bartlett, MDFrom Johns Hopkins University School of Medicine, Baltimore, MD 21287, University of Virginia Health Sciences Center, Charlottesville, VA 22908.Search for more papers by this author and Frederick G. Hayden, MDFrom Johns Hopkins University School of Medicine, Baltimore, MD 21287, University of Virginia Health Sciences Center, Charlottesville, VA 22908.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-144-4-200602210-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:In our editorial, we stated that personal stockpiles of antiviral agents may make “good sense.” Dr. Rolfsen makes a now more obvious point about the problem of drug shortage in the event of widespread procurement of personal stockpiles. This is an issue that has become the subject of some substantial analysis and concern since our editorial was submitted. We agree with Dr. Rolfsen and with the position statement of the Infectious Diseases Society of America (www.idsociety.org), which advises against personal stockpiling of these drugs. The possible need for personal stockpiles was mitigated when the U.S. Department of Health ...Reference1. U.S. Department of Health and Human Services. HHS Pandemic Influenza Plan. Accessed at www.hhs.gov/pandemicflu/plan/ on 12 January 2006. Google Scholar Author, Article, and Disclosure InformationAuthors: John G. Bartlett, MD; Frederick G. Hayden, MDAffiliations: From Johns Hopkins University School of Medicine, Baltimore, MD 21287, University of Virginia Health Sciences Center, Charlottesville, VA 22908.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoInfluenza A (H5N1): Will It Be the Next Pandemic Influenza? Are We Ready? John G. Bartlett and Frederick G. Hayden The Ethics of Personal Stockpiles Michael L. Rolfsen Metrics 21 February 2006Volume 144, Issue 4Page: 304-305KeywordsAntiviralsConflicts of interestDrugsHealth careHealth care providersInfectious diseasesPatientsVaccines ePublished: 21 February 2006 Issue Published: 21 February 2006 Copyright & PermissionsCopyright © 2006 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Case 17-1978
Authors: Richard C. Cabot, Robert E. Scully, James J. Galdabini, Betty U. McNeely, Arnold S. Relman, Robert T. McCluskey
Journal: New England Journal of Medicine (1978)

Presentation of CaseA 44-year-old electrician from Nantucket was admitted to the hospital because of hemoptysis and renal failure.He was well until seven years earlier, when he had an anterolateral myocardial infarct. He recovered except for occasional dyspnea and episodes of anterior chest pain. Three months before admission, during a trip to Guadeloupe, diarrhea and abdominal distress occurred for one day. One week before entry, on return from a trip to Puerto Rico, he began to complain of a productive cough, with rise of the temperature to 38.9°C. An x-ray film of the chest (Fig. 1), taken at another . . .
MicroRNA-155 promotes atherosclerosis by repressing Bcl6 in macrophages
Authors: Maliheh Nazari-Jahantigh, Yuanyuan Wei, Heidi Noels, Shamima Akhtar, Zhe Zhou, Rory R. Koenen, Kathrin Heyll, Felix Gremse, Fabian Kiessling, Jochen Grommes, Christian Weber, Andreas Schober
Journal: Journal of Clinical Investigation (2012)

Macrophages in atherosclerotic plaques drive inflammatory responses, degrade lipoproteins, and phagocytose dead cells. MicroRNAs (miRs) control the differentiation and activity of macrophages by regulating the signaling of key transcription factors. However, the functional role of macrophage-related miRs in the immune response during atherogenesis is unknown. Here, we report that miR-155 is specifically expressed in atherosclerotic plaques and proinflammatory macrophages, where it was induced by treatment with mildly oxidized LDL (moxLDL) and IFN-γ. Leukocyte-specific Mir155 deficiency reduced plaque size and number of lesional macrophages after partial carotid ligation in atherosclerotic (Apoe–/–) mice. In macrophages stimulated with moxLDL/IFN-γ in vitro, and in lesional macrophages, loss of Mir155 reduced the expression of the chemokine CCL2, which promotes the recruitment of monocytes to atherosclerotic plaques. Additionally, we found that miR-155 directly repressed expression of BCL6, a transcription factor that attenuates proinflammatory NF-κB signaling. Silencing of Bcl6 in mice harboring Mir155–/– macrophages enhanced plaque formation and CCL2 expression. Taken together, these data demonstrated that miR-155 plays a key role in atherogenic programming of macrophages to sustain and enhance vascular inflammation.
Serum Ferritin Fails to Indicate Hemochromatosis — Nothing Gold Can Stay
Authors: William H. Crosby
Journal: New England Journal of Medicine (1976)

For several years we have enjoyed a comfortable certainty that serum ferritin would provide, in healthy people, an accurate reflection of the body's stores of iron.1 , 2 Although the test is exasperatingly difficult to perform, once established it seemed able to sort out people with iron deficiency (even without anemia) and those with hemochromatosis (even before the iron deposits had ruined their liver, pancreas and testicles). Now that reflection has been tarnished. Wands et al., at the Massachusetts General Hospital (page 302), have demonstrated normal ferritin levels in iron-loaded people afflicted with preclinical familial hemochromatosis. There is no doubting their data. . . .
Hope or Hype: The Obsession with Medical Advances and the High Cost of False Promises
Authors: Ray Moynihan
Journal: BMJ (2006)

I magine, if you will, a long line running from left to right, from one extreme to the other. The pole at the left hand end of the continuum represents a pathological obsession with new health technologies, and at the right hand end an all-consuming cynical rejection of the value of medical advances. Somewhere in the middle is the healthy scepticism we all strive for, yet find so elusive, particularly when we or our loved ones fall ill.

Richard A Deyo, Donald L Patrick

Amacon, $24.95, pp 336 ISBN 0 8144 0845 1 www.amacombooks.org

Rating: …
Lack of relation between venous plasma total catecholamine concentrations and ventricular arrhythmias after acute myocardial infarction.
Authors: R C Strange, M J Rowe, M F Oliver
Journal: BMJ (1978)

Electrocardiographic tracings were recorded continuously to monitor ventricular tachycardia and R-on-T and R-on-apex-T ventricular premature beats, and repeated estimations of venous plasma total catecholamine concentrations were carried out in 26 patients admitted to a coronary care unit with acute myocardial infarction. No relation existed between the increased catecholamine concentrations found in these patients and the incidence of ventricular arrhythmias occurring six to 48 hours after the onset of symptoms.
Tidal Volumes For Ventilated Infants Should Be Determined with a Pneumotachometer Placed at the Endotracheal Tube
Authors: MICHAEL L. CANNON, JACK CORNELL, DONNA S. TRIPP-HAMEL, MICHAEL A. GENTILE, CHRISTOPHER L. HUBBLE, JON N. MELIONES, IRA M. CHEIFETZ
Journal: American Journal of Respiratory and Critical Care Medicine (2000)

Many ventilators measure expired tidal volume (Vt) without compensation either for the compliance of the ventilator circuit or for variations in the circuit setup. We hypothesized that the exhaled Vt measured with a conventional ventilator at the expiratory valve would differ significantly from the exhaled Vt measured with a pneumotachometer placed at the endotracheal tube. To investigate this we studied 98 infants and children requiring conventional ventilation. We used linear regression analysis to compare the Vt obtained with the pneumotachometer with the ventilator-measured volume. An additional comparison was made between the pneumotachometer volume and a calculated effective Vt. For infant circuits (n = 70), our analysis revealed a poor correlation between the expiratory Vt measured with the pneumotachometer and the ventilator-measured volume (r2 = 0.54). Similarly, the expiratory Vt measured with the pneumotachometer did not correlate with the calculated effective volume (r2 = 0.58). For pediatric circuits (n = 28), there was improved correlation between the expiratory Vt measured with the pneumotachometer and both the ventilator-measured volume and the calculated effective Vt (r2 = 0.84 and r2 = 0.85, respectively). The data demonstrate a significant discrepancy between expiratory Vt measured at a ventilator and that measured with a pneumotachometer placed at the endotracheal tube in infants. Correcting for the compliance of the ventilator circuit by calculating the effective Vt did not alter this discrepancy. In conventionally ventilated infants, exhaled Vt should be determined with a pneumotachometer placed at the airway.
Atlas of General Surgery
Authors: B. Eiseman
Journal: JAMA (1994)

Recent atlases of general surgery have been largely monotonous. With the introduction of minimal access operative techniques, however, a new day is dawning. If this is, in fact, a Renaissance, then Gordon may be the Leonardo and Sabiston the Lorenzo who, together, are the illuminators of the revival. Their big atlas is refreshingly crisp, up-to-date, and helpful in its description of new and essential operative techniques for the general surgeon. The appeal will be primarily to surgeons whose practice demands familiarity with staples, minimal access techniques, endoscopes, and ambulatory surgery—entities not a part of their residency training only a few years ago. A major benefit of this atlas is its currency. Within the remarkably short period of two years, Gordon drew each of the 1010 sophisticated but clear line drawings—this amounts to almost three drawings a day including Saturdays and Sundays. The result is a clear, uniform, state-of-the-art illustration of
Differential processing of proenkephalin-A by human peripheral blood monocytes and T lymphocytes.
Authors: W Kuis, P M Villiger, H G Leser, M Lotz
Journal: Journal of Clinical Investigation (1991)

Human peripheral blood mononuclear cells are analyzed for preproenkephalin gene expression and peptide processing. Met-enkephalin immunoreactivity as detected with a specific antiserum is found in the cytoplasm of monocytes but not in T lymphocytes. Secretion of met-enkephalin was analyzed with an RIA that is specific for the met-enkephalin pentapeptide. Unfractionated PBMC spontaneously released 40 pg/ml met-enkephalin and this increased two- to fourfold after stimulation with PHA. Lower levels (less than 100 pg/ml) of met-enkephalin were detected in supernatants from purified T cells that were activated with PHA and IL-2. In contrast, stimulation of purified monocytes with LPS or PMA resulted in the release of up to 600 pg/ml of the processed peptide. To examine whether T cells can produce met-enkephalin precursor peptides, T cell conditioned media were treated with trypsin and carboxypeptidase-B, which is known to release met-enkephalin from the propeptide. This increased levels of met-enkephalin to 400 pg/ml, indicating that lymphocytes secrete the propeptide but do not process it to met-enkephalin. The 1.4-kb preproenkephalin mRNA is detected in activated blood mononuclear cells and in purified monocytes and T cells. To determine whether monocytes or lymphocytes express met-enkephalin in vivo, lymphoid tissues were analyzed by immunohistochemistry. In human spleen tissue, positive cells were found in the red pulp but not in the follicles, which is also consistent with met-enkephalin expression in monocytes. In summary, these results show that human peripheral blood mononuclear cells express preproenkephalin mRNA and that monocytes, but not T cells, process the propeptide to metenkephalin.
Telomeres and chromosomal instability in chronic lymphocytic leukemia
Authors: L Véronèse, O Tournilhac, M Callanan, N Prie, F Kwiatkowski, P Combes, M Chauvet, F Davi, L Gouas, P Verrelle, R Guièze, P Vago, J O Bay, A Tchirkov
Journal: Leukemia (2012)
An acid-labile temperature-responsive sol–gel reversible polymer for enhanced gene delivery to the myocardium and skeletal muscle cells
Authors: Ran Namgung, Sujin Nam, Soo Kyung Kim, Sejin Son, Kaushik Singha, Jin-Sook Kwon, Youngkeun Ahn, Myung Ho Jeong, In-Kyu Park, Vivek K. Garripelli, Seongbong Jo, Won Jong Kim
Journal: Biomaterials (2009)
The α component of the CNTF receptor is required for signaling and defines potential CNTF targets in the adult and during development
Authors: Nancy Y. Ip, Joyce McClain, Nestor X. Barrezueta, Thomas H. Aldrich, Li Pan, Yanping Li, Stanley J. Wiegand, Beth Friedman, Samuel Davis, George D. Yancopoulos
Journal: Neuron (1993)
Ectopic Pregnancy Associated With Use of an Intrauterine Contraceptive Device
Authors: Yoshiaki Tsukada
Journal: JAMA (1968)

Rupture of a tube in ectopic pregnancy was associated with the wearing of an intrauterine contraceptive device (IUD) in two women. Both patients died from hemorrhage. Difficulty in clinical diagnosis appeared to be related to the presence of the IUD. The device probably prevents endometrial implantation and, less effectively, tubal implantation of the fertilized ovum. Consequently, the rate of tubal pregnancy is relatively increased. Possible ectopic pregnancy should be considered in the differential diagnosis of an acute abdomen in a woman using an IUD.
Prostaglandins contribute to activation of baroreceptors in rabbits. Possible paracrine influence of endothelium.
Authors: H I Chen, M W Chapleau, T S McDowell, F M Abboud
Journal: Circulation Research (1990)

The purpose of this study was to test the hypothesis that prostaglandins released from vascular endothelial cells contribute to activation of baroreceptors during increases in arterial pressure. Baroreceptor activity was recorded from the vascularly isolated carotid sinus in rabbits anesthetized with chloralose. Baroreceptor activity was measured during ramp or step increases in nonpulsatile carotid sinus pressure over a range of 0-175 mm Hg. Exposure of the isolated carotid sinus to inhibitors of prostaglandin formation (indomethacin [n = 10] or aspirin [n = 6]) decreased baroreceptor activity significantly (p less than 0.05). The slope of the pressure-activity relation averaged 0.80 +/- 0.07 %/mm Hg (mean +/- SEM) during control measurements and 0.72 +/- 0.06 and 0.63 +/- 0.05 %/mm Hg during exposure to 10 and 20 microM indomethacin, respectively. Exposure of the carotid sinus to exogenous prostacyclin (PGI2 [n = 11]) increased baroreceptor activity significantly. The slope of the pressure-activity relation averaged 0.89 +/- 0.10, 1.09 +/- 0.09, and 1.26 +/- 0.16 %/mm Hg during control and during exposure to 10 and 20 microM PGI2, respectively. Activity returned to control after removal of PGI2 (0.89 +/- 0.12 %/mm Hg). Removal of endothelium with either a balloon catheter (n = 4) or a jet of a 95% O2-5% CO2 gas mixture (n = 6) decreased the slope of the pressure-activity relation from 0.92 +/- 0.09 to 0.56 +/- 0.08 %/mm Hg (p less than 0.05). Exposure of the denuded sinus to exogenous PGI2 (20 microM [n = 4]) restored activity (slope = 1.09 +/- 0.24 %/mm Hg). Neither indomethacin (n = 5) nor PGI2 (n = 5) nor denudation (n = 5) significantly altered the pressure-diameter relation of the carotid sinus (sonomicrometers), suggesting that the effects on baroreceptor discharge are not caused by altered stretch of the carotid sinus at a given pressure. The results suggest that prostaglandins (e.g., PGI2) released from endothelium contribute in a paracrine manner to activation of baroreceptors during increases in arterial pressure.
The Radiology of Tuberculosis
Authors: Paul T. Davidson
Journal: JAMA (1980)

The title of this book is something of a misnomer, since the subject material, originally published in the July and October 1979 issues of<i>Seminars in Roentgenology</i>, includes general information about tuberculosis, with excellent chapters on the clinical and laboratory aspects and one on pathology. The remaining chapters are well illustrated and at their best when the radiologist authors confine themselves to radiological subjects. They are at their weakest when the same authors stray into other areas where some have a tendency to quote occasionally from ancient sources, material that is incomplete, out of context, or irrelevant. This only annoys one knowledgeable about tuberculosis, but it could be seriously misleading to the novice. The chapters on extrapulmonary tuberculosis are of particular value and include good discussions and illustrations of bone and joint, gastrointestinal, genitourinary, intracranial, and laryngeal disease. Standard textbooks usually cover these topics briefly and without illustrations, limiting their