tbuckley/cabot-search huggingface dataset:
Effects of renal and hepatic venous congestion on renal function in the presence of low and normal cardiac output in dogs.
Authors: H J Priebe, J C Heimann, J Hedley-Whyte
Journal: Circulation Research (1980)

We investigated the effect of acute renal vein and hepatic vein hypertension induced by partial balloon-occlusion of the abdominal inferior vena cava (AIVC-O) and the thoracic inferior vena cava (TIVC-O) on systemic and renal hemodynamics and renal function in 13 dogs anesthetized with pentobarbital. When a renal vein pressure of 13 cm H2O was induced by AIVC-O, cardiac output, stroke volume, central venous pressure, renal blood flow, and renal function (GFR, free water clearance, osmolar clearance, urine output, urinary sodium excretion, fractional sodium excretion) decreased significantly. When systemic hemodynamics were restored to control values by transfusion of autologous blood (mean of 9 ml/kg body weight) while renal vein pressure was kept elevated, renal function also was restored. A hepatic venous pressure of 13 cm H2O then was induced by TIVC-O. The effects on systemic hemodynamics and renal function were very similar to those observed during AIVC-O. When systemic hemodynamics were restored to control values by transfusion (mean of 9 ml/kg), while hepatic venous hypertension was maintained by TIVC-O, renal function also was restored. Despite significant changes in natriuresis and diuresis, intrarenal blood flow distribution, as determined by the radioactive microsphere technique, remained essentially unchanged throughout. We conclude that renal and hepatic congestion induced by partial AIVC-O and TIVC-O do not, per se, alter renal function significantly.
CLINICAL DETERMINANTS OF INCIDENT AORTIC STENOSIS IN STATIN–TREATED STABLE CORONARY PATIENTS
Authors: Benoit Arsenault, Matthijs Boekholdt, Samia Mora, David DeMicco, Warren Bao, Prakash Deedwania, Jean Claude Tardif, John C. LaRosa, Philip Barter, David Waters
Journal: Journal of the American College of Cardiology (2013)
Assessment of aortic regurgitation by the acceleration flow signal void proximal to the leaking orifice in cinemagnetic resonance imaging.
Authors: K Yoshida, J Yoshikawa, T Hozumi, T Akasaka, Y Yamaura, S Minagoe, H Nakajima, T Miyamoto
Journal: Circulation (1991)

BACKGROUND The proximal acceleration flow region is a laminar flow field that is located immediately upstream from the leaking orifice. The purpose of this study was to evaluate whether cinemagnetic resonance imaging can provide information regarding the proximal acceleration flow region in patients with aortic regurgitation and to analyze the relation between the area of the proximal acceleration flow delineated by cinemagnetic resonance imaging and the severity of aortic regurgitation delineated by angiography. METHODS AND RESULTS Thirty-eight consecutive patients who underwent aortography were examined by cinemagnetic resonance imaging. The region of proximal flow acceleration was identified as a semicircular-shaped signal void in the aorta during diastole. Cinemagnetic resonance imaging detected the proximal acceleration flow region in 26 of the 30 patients who were proved to have this lesion (sensitivity, 87%). In eight patients without aortic regurgitation according to aortography, no proximal acceleration flow region was detected (specificity, 100%). The area of the acceleration flow signal void from the long-axis view was well correlated with angiographic degree of aortic regurgitation. CONCLUSIONS Cinemagnetic resonance imaging is useful in detecting the proximal acceleration flow region and permits noninvasive assessment of the severity of aortic regurgitation.
Blood Transfusion in Nocturnal Haemoglobinuria
Authors: J. V. Dacie, D. Firth
Journal: BMJ (1943)

The very short incubation period would, however, make this improbable unless the infection had been an ante-natal one.4. The fact that infants seldom or never seem to have a recur- rence of the infection after removal to the " septic " nursery has been referred to.On one occasion this did occur, and four infants cured and ready to go out showed a fresh infection simultaneously, two with conjunctivitis and two with a rash on the face.A nurse known to be a carrier of Staph.aureus and to suffer occasionally from folliculitis of the nares had been transferred three days previously to this ward.A comparison of her cultures with those of the strains isolated from the infants' lesions showed three of them to be closely similar, and it seems probable that the new infection was derived from her.The table below shows the similarity of the cultures of Nurse A to those from the two cases of conjunctivitis and one pustule.Culttires from Nurse and Babies of D 1 Ward Diffusing No.
Comparison of multiple views for the evaluation of pulmonary arterial blood flow by Doppler echocardiography.
Authors: G W Lighty, A Gargiulo, I Kronzon, F Politzer
Journal: Circulation (1986)

Forty adult patients underwent Doppler and two-dimensional echocardiographic examination of the pulmonary artery from multiple views to determine the variability in the magnitude of Doppler-determined flow velocity and pulmonary arterial diameter from various echocardiographic windows. Flows were recorded from two or more views in 32 patients (80%). Twelve of these patients (38%) had flow velocities recorded from two or more views that were within 6% of each other. Twenty of these patients (62%) had view-dependent differences in measured flow velocity ranging from 7% to 48%. The commonly used parasternal short-axis view yielded the highest pulmonary arterial flow velocity in only 35% of the patients studied. Determinations of pulmonary arterial blood flow can vary markedly when measured from different sites, and this is presumably due to varying ability to approximate a zero-degree Doppler angle from different views. Measurement of pulmonary arterial flow velocity should be attempted from multiple views, and the highest flow velocity should be selected as that obtained with the best zero-degree Doppler angle approximation.
Munchausen to Münchhausen
Authors: HEINRICH TAEGTMEYER
Journal: Annals of Internal Medicine (1977)

Letters and Corrections1 September 1977Munchausen to MünchhausenHEINRICH TAEGTMEYER, M.D.HEINRICH TAEGTMEYER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-87-3-379_4 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Sociopathic patients who feign illness are thought to have the "Munchausen Syndrome." From my boyhood in Germany I remember Munchausen's tales in a slightly different way: as examples of obvious and ridiculous lies. I am still somewhat puzzled about how the "Liar Baron" could find his way into the medical literature.Nonetheless the history of Munchausen's tales might be of some interest to readers. I, like Dr. Brugsch (Ann Intern Med86:833-834, 1977), was curious about the correct spelling of Munchausen's name, and as a result I recently was able to learn about the unusual bilingual heritage...Reference1. CARSWELL J: Introduction, in Singular Travels, Campaigns and Adventures of Baron Munchausen, edited by RASPE RE, et al. New York, Dover Publications, 1960, pp. I-XXXVII Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Cardiovascular Division Peter Bent Brigham Hospital 721 Huntington Ave. Boston, MA 02115 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByMore on MunchausenRICHARD L. GOLDEN, M.D.More on MunchausenRICHARD L. GOLDEN, M.D. 1 September 1977Volume 87, Issue 3Page: 379-380 Issue Published: 1 September 1977 PDF DownloadLoading ...
157 BONE DISORDERS BEFORE AND AFTER LIVER TRANSPLANTATION
Authors: P.A. Galtieri, B. Lattanzi, M. Giusto, V. Giannelli, C. Lucidi, V. Di Gregorio, K. Koryukova, G. Mennini, M. Rossi, S. Ginanni Corradini, C. Albanese, M. Merli
Journal: Journal of Hepatology (2013)
Panel calls for FDA to issue safety advice for metal-on-metal hip replacements
Authors: B. Roehr
Journal: BMJ (2012)

An FDA advisory committee inquiry into metal-on-metal hip replacements was unable to determine whether all such implants were at risk of becoming damaged and shedding cobalt and chromium ions with effect on surrounding muscle tissue.

The committee spent two days wrestling with issues surrounding the 750 000 metal-on-metal hip replacements that have been done in the US. The agency was trying to sort out often conflicting data and interpretations of those data in updating its policy on the devices.

Two recent investigations by the BMJ have raised serious concerns about the regulation of medical devices and problems with metal-on-metal implants caused by metal ions leaking into the body.1 2 After publication of the articles, the UK’s Medicines and Healthcare Products Regulatory Agency recommended that all patients with metal-on-metal hip implants with a femoral diameter of ≥36 mm have annual blood tests to check metal ion …
A CONTRIBUTION TO THE EPIDEMIOLOGY OF POLIOMYELITIS
Authors: Simon Flexner, Paul F. Clark, Harold L. Amoss
Journal: The Journal of Experimental Medicine (1914)

A strain of the poliomyelitic virus was propagated in monkeys for four years, during which time it displayed three distinct phases of virulence. The several phases covered different periods of time. At the outset the virulence was low, but by animal passages it quickly rose to a maximum; this maximum was maintained for about three years, when, without known changes in the external conditions, a diminution set in and increased until at the expiration of a few months the degree of virulence about equalled that present at the beginning of the passages in monkeys. The cycle of changes in virulence is correlated with the wave-like fluctuation in epidemics of disease which also consist of a rise, temporary maximum, and fall in the number of cases prevailing. And an explanation of epidemics of disease is inferred in variations or mutations among the microörganismal causes of disease affecting chiefly the quality of their virulence.
The problem of the null in the verification of unconscious cognition
Authors: Eric Luis Uhlmann
Journal: Behavioral and Brain Sciences (2014)

Abstract Newell &amp; Shanks (N&amp;S) argue that when awareness measures are more reliable and valid, greater evidence of awareness of supposedly unconscious influences is revealed. A related issue is that unconsciousness is typically the null hypothesis that evidence of awareness will not emerge. As it is difficult to conclude the null, it is also difficult to conclude a lack of conscious awareness.
Interstrain differences in chronic hepatitis and tumor development in a murine model of inflammation-mediated hepatocarcinogenesis
Authors: Tamara Potikha, Evgeniy Stoyanov, Orit Pappo, Antonina Frolov, Lina Mizrahi, Deborah Olam, Temima Shnitzer-Perlman, Ido Weiss, Neta Barashi, Amnon Peled, Gabriele Sass, Gisa Tiegs, Francoise Poirier, Gabriel A. Rabinovich, Eithan Galun, Daniel Goldenberg
Journal: Hepatology (2013)

Chronic inflammation is strongly associated with an increased risk for hepatocellular carcinoma (HCC) development. The multidrug resistance 2 (Mdr2)-knockout (KO) mouse (adenosine triphosphate-binding cassette b4(-/-) ), a model of inflammation-mediated HCC, develops chronic cholestatic hepatitis at an early age and HCC at an adult age. To delineate factors contributing to hepatocarcinogenesis, we compared the severity of early chronic hepatitis and late HCC development in two Mdr2-KO strains: Friend virus B-type/N (FVB) and C57 black 6 (B6). We demonstrated that hepatocarcinogenesis was significantly less efficient in the Mdr2-KO/B6 mice versus the Mdr2-KO/FVB mice; this difference was more prominent in males. Chronic hepatitis in the Mdr2-KO/B6 males was more severe at 1 month of age but was less severe at 3 months of age in comparison with age-matched Mdr2-KO/FVB males. A comparative genome-scale gene expression analysis of male livers of both strains at 3 months of age revealed both common and strain-specific aberrantly expressed genes, including genes associated with the regulation of inflammation, the response to oxidative stress, and lipid metabolism. One of these regulators, galectin-1 (Gal-1), possesses both anti-inflammatory and protumorigenic activities. To study its regulatory role in the liver, we transferred the Gal-1-KO mutation (lectin galactoside-binding soluble 1(-/-) ) from the B6 strain to the FVB strain, and we demonstrated that endogenous Gal-1 protected the liver against concanavalin A-induced hepatitis with the B6 genetic background but not the FVB genetic background.Decreased chronic hepatitis in Mdr2-KO/B6 mice at the age of 3 months correlated with a significant retardation of liver tumor development in this strain versus the Mdr2-KO/FVB strain. We found candidate factors that may determine strain-specific differences in the course of chronic hepatitis and HCC development in the Mdr2-KO model, including inefficient anti-inflammatory activity of the endogenous lectin Gal-1 in the FVB strain.
Diagnosis of type II enteropathy‐associated T‐cell lymphoma should be limited to EBER− cases
Authors: Soo‐Yong Tan, Shigeo Nakamura, Hwan‐Cheong Tan, Yan‐hui Liu, Shih‐Sung Chuang
Journal: American Journal of Hematology (2012)

We read with interest the series of Type II enteropathy-associated T-cell lymphoma (EATL) by Tse et al. [1]. As this is a rare disease that is more commonly encountered in Asia, such an attempt to assemble cases from the region in order to define its clinicopathological features is laudable. Nevertheless, we would express some concern over the inclusion of three cases with extensive EBV encoded RNA (EBER) expression in the study. These cases were included because they were morphological mimics of Type II EATL, lacked angiocentricity, and showed clonal rearrangement of TCR gene. Similar cases have been documented to be of T-cell lineage by double labeling and T-cell clonality study [2]. In addition, the lack of features such as angiocentricity and necrosis does not exclude extranodal NK/T-cell lymphoma (ENKL) and this neoplasm may also include cases of both NK and T-cell origins [3, 4]. EBER-positivity is characteristic of ENKL, both in cases with NK-lineage (the majority of cases) or T-cell lineage (around 10% of cases, but up to 27% has been reported) [5]. In contrast, the overwhelming majority of Type II EATL has been shown to be EBER− [6-8] and isolated EBER+ cells in this neoplasm are in fact EBV-infected B-cells (Fig. 1). Type II EATL is a newly recognized entity that needs to be properly defined and understanding of this disease is being accumulated gradually with increasing experience. It would be prudent to keep this entity pure at this stage and limit it to EBER− cases. The occasional EBER+ cases can be incorporated at a later stage when more evidence emerges to support its inclusion. Scattered EBER+ cells in Type II EATL are mostly EBV-infected B-cells by double staining technique. Soo-Yong Tan*, Shigeo Nakamura , Hwan-Cheong Tan*, Yan-hui Liu , Shih-Sung Chuang§, * Department of Pathology, Singapore General Hospital, Singapore, Department of Pathology and Laboratory Medicine, Nagoya University Hospital, Nagoya, Japan, Department of Pathology, Guangdong General Hospital, Guangzhou, China, § Department of Pathology, Chi-Mei Medical Center, Tainan and Taipei Medical University, Taipei, Taiwan.
Endoscopic treatment of spontaneous, incomplete esophageal rupture in a patient with “crackleware esophagus”
Authors: E. Kieninger, F. Siebert, C. Langner
Journal: Endoscopy (2009)

A 51-year-old woman presented with acute epigastric pain after ingestion of a rice meal. The patient’s history was unremarkable apart from a long-term habit of ingestion of hot peppermint candies and nicotine misuse (20 cigarettes per day). Examination of the oral cavity revealed patchy leukoplakia. Laboratory tests were unremarkable apart from positive antinuclear antibody (ANA) (1 : 320) and positive anti-dsDNA antibodies. Gastroscopy disclosed a 6 cm long, incomplete rupture extending into the muscularis propria of the middle third of the esophagus ([Fig. 1 a]). The surrounding mucosa appeared thickened and showed areas of diffuse keratinization, thus acquiring a ”crackleware“ appearance. On histological examination, extensive hyperkeratosis was noted ([Fig. 1 b]). Biopsy specimens taken from the gastroesophageal junction revealed mild reflux disease. Further investigations with respect to esophageal involvement in collagenosis-associated motility disorders (including oesophageal manometry), however, were negative.
Ocular Manifestations of Wegener's Granulomatosis-Reply
Authors: Michael C. Sneller
Journal: JAMA (1995)

<h3>In Reply.</h3> —Dr Flach raises some important points about ocular manifestations of Wegener's granulomatosis. In my original Grand Rounds presentation at the National Institutes of Health Clinical Center, the various ocular manifestations of Wegener's granulomatosis were discussed. However, because of space limitations, a significant amount of information on the pathophysiology, clinical manifestations, diagnosis, and management of Wegener's granulomatosis could not be included in this published article. For a more complete discussion of Wegener's granulomatosis, including the ocular manifestations, I would refer interested readers to the articles cited in the letter by Flach and to other articles by our group.<sup>1-3</sup>
Influenzal Meningitis in a Child aged 2 treated with Sulphapyridine: Recovery
Authors: M. E. Matthews
Journal: BMJ (1943)

This last, in view of lknown facts as to sensitization and allergy, appears to be rational, and was therefore adopted in this investigation.That negative skin tests do not exclude intolerance to liver extract is shown by Case 2, in which these were negative 18 months after the onset of symptoms and became positive only during the attempt at desensitization.Two methods may be adopted for the parenteral administration of liver extract to intolerant patients: lasting desensitization can be achieved by a course of liver injections in increasing doses over several weeks; alternatively, the required dose may be given in small injections, preferably over two days.The latter method does not increase the tolerance of the patient to future doses.Summary Three cases of pernicious anaemia are described in which the patient had become " sensitive " to the parenteral injection, of liver extract.Skin tests cannot be relied upon to indicate intolerance.By the use of divided doses of liver extract over a period of several weeks it proved possible to desensitize two patients to the extent that they became able to tolerate their full require- ment, of liver extract in one injection at monthly intervals.In a third case the required dose is being given in small injections over two days without attempt at permanent desensitization.My thanks are due to Dr. S. C. Dyke for access to records and advice, and to Sister Dora Martin for care and supervision
Memories of lunar caustic
Authors: T. Dalrymple
Journal: BMJ (2011)

As every doctor knows, it is one thing to dry out an alcoholic and quite another to get him to stop drinking afterwards. Maybe it isn’t even the doctor’s role to do so: after all, are they their patients’ keepers?

In any case, some alcoholics have so destroyed their lives, and for so long, that they might as well go on. What will they do if they give up drinking? Malcolm Lowry (1909-57), author of Under the Volcano , seemed not to fall into this lamentable category. Strikingly good looking, he was only 47 when he died, a talented and famous author, and might have written many more books.

On …
Abstract 224: Antitumorigenic effect of synthetic C-substituted diindolyl methanes originating from cruciferous vegetables in KB human oral cancer cells through endoplasmic reticulum stress
Authors: Eun-Sun Choi, Jung-Hyun Shim, Sung-Dae Cho, Nam-Pyo Cho
Journal: Cancer Research (2010)

Abstract Diindolylmethane (DIM), an isothiocyanates found in cruciferous vegetables, has been shown to have cancer chemopreventive effects. A series of synthetic C-substituted DIMs (C-DIMs) analogs was developed, including DIM-C-pPhtBu and DIM-C-pPhC6H5, which exhibited better inhibitory activity in cancer cells than DIM. This study examined the effects of C-DIMs on the growth of KB human oral cancer cells. DIM-C-pPhtBu and DIM-C-pPhC6H5 decreased the number of viable cells and induced caspase-dependent apoptosis. The apoptotic cell death was accompanied by a change in Bax/Bcl-2 ratio and damage to mitochondrial membrane potential through the induction of Death Receptor 5 and the cleavage of bid and caspase 8. Mechanistic studies demonstrated that the apoptotic cell death induced by DIM-C-pPhtBu and DIM-C-pPhC6H5 was mediated by endoplasmic reticulum (ER) stress. This provides the first evidence that synthetic C-DIMs originating from cruciferous vegetables induce apoptosis in KB cells via the ER stress pathway. This study was supported by Bio R&amp;D program through the Korea Science and Engineering Foundation funded by the Ministry of Education, Science and Technology (M10870050003-08N7005-00311) and National Research Foundation of Korea Grant funded by the Korean Government (KRF-2008-331-E00260). Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 224.
Prevention and Treatment of Pressure Ulcers
Authors: John W. Curtin
Journal: JAMA (1987)

<h3>To the Editor.—</h3> Lest the article on prevention and treatment of pressure ulcers, in the Feb 6 issue ofThe Journal,<sup>1</sup>portray to the reader that this represents the present-day "state of the art," I would like to set the record straight. We are certainly in accord with Dr Lorincz, a dermatologist, and Dr Silvetti, a laboratory research physician, that many pressure ulcers can be prevented. Their establishment of a Wound Healing Research Center and an educational program on prevention of pressure ulcers must be commended. I take issue, however, with their statements involving the treatment of these ulcers and in particular the "deep, complicated ulcers." I have not been privileged to see their article on the subject, but Virginia Cowart, in her<i>JAMA</i>report, comes away with a misconception as to the real reason for the ulcer. Nowhere in her article is there mention of the presence of
Elwyn Trefor Hughes
Authors: W J C Roberts
Journal: BMJ (2004)

Former general practitioner Aberystwyth (b Aberystwyth 1926; q the London Hospital 1948; FRCP Ed), d 29 February 2004.

Other than for two years of national service as a captain and junior specialist in the Royal Army Medical Corps Elwyn continued in the environs of the London Hospital up to 1958. He was a medical registrar on the London Hospital neurology unit when in 1958 he left to take up a post in general practice in Aberystwyth. He also became a hospital clinical assistant and later had a senior role in adult medicine until 1986. He retired from general practice in 1991. Elwyn was a past chairman of the Aberystwyth division of the BMA and an enthusiastic violinist. He leaves a wife, Lillias; two children; and two grandchildren.