tbuckley/cabot-search huggingface dataset:
Atropine and a Hypertensive Crisis
Authors: SHOJI SESOKO
Journal: Annals of Internal Medicine (1984)

Letters and Corrections1 November 1984Atropine and a Hypertensive CrisisSHOJI SESOKO, M.D., NAOMICHI MIYAZAKI, M.D., YOSHIO KATO, M.D., OSAMU TOCHIKUBO, M.D., YOSHIHIRO KANEKO, M.D.SHOJI SESOKO, M.D., NAOMICHI MIYAZAKI, M.D., YOSHIO KATO, M.D., OSAMU TOCHIKUBO, M.D., YOSHIHIRO KANEKO, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-101-5-720_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The relation between parasympathetic nerve activity and hypertension is still not clear, although the mechanisms whereby the sympathetic nervous system affects blood pressure have been clarified in recent studies. To investigate the parasympathetic nerve mechanisms contributing to hypertension, we have been carrying out studies with atropine injections (1, 2) in hypertensive patients. We report a case with evidence that atropine injection induced a hypertensive crisis in a patient with hypertension.A 28-year-old man was found to have hypertension (blood pressure 188/90 mm Hg) and proteinuria, but not renal dysfunction (serum creatinine level, 1.2 mg/dL) in May 1982....References1. JULIUSPASCUALLONDON SAR. Role of parasympathetic inhibition in the hyperkinetic type of borderline hypertension. Circulation. 1971;44:413-8. CrossrefMedlineGoogle Scholar2. PICKERINGGRIBBONPETERSENCUNNINGHAMSLEIGHT TBEJP. Effects of autonomic blockade on the baroreflex in man at rest and during exercise. Circ Res. 1972;30:177-85. CrossrefMedlineGoogle Scholar3. MAN IN'T VELDWENTINGBOOMSMAVERHOEVENSCHALEKAMP AGFRM. Sympathetic and parasympathetic components of reflex cardiostimulation during vasodilator treatment of hypertension. Br J Clin Pharmacol. 1980;9:547-51. CrossrefMedlineGoogle Scholar4. TRIMARCOVOLPERICCIARDELLI BMB. Baroreflex responsiveness in borderline hypertensives: a study with neostigmine. Cardiovasc Res. 1981;15:436-42. CrossrefMedlineGoogle Scholar5. PFEIFERWEINBERGCOOKBESTREENANHALTER MCDJAJ. Differential changes of autonomic nervous system function with age in man. Am J Med. 1983;75:249-58. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Yokohama City University, School of Medicine Yokohama 232 Japan PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPathophysiology, clinical aspects, and treatment of hypertensive crisesLetters to the Editor and Informed ConsentDAVID NAYLOR, M.D., D. Phil.Pseudopheochromocytoma. 1 November 1984Volume 101, Issue 5Page: 720-720KeywordsAtropineBlood pressureCreatinineHypertensionNervesProteinuriaSympathetic nervous system ePublished: 1 December 2008 Issue Published: 1 November 1984 PDF downloadLoading ...
Present-day Neurophysiological Models of Mind-body Interaction
Authors: M. Dongier, N. Koninckx
Journal: Psychotherapy and Psychosomatics (1970)

New neurophysiological tools such as computers and averagers allow studies of reactions of the brain to various kinds of symbolic stimuli. So far only very simple models of meaningful situations have been developed. However it can be shown that the slow potential changes they induce differ, in psychosomatic patients, from normal controls and from psychotic patients. It is hoped that more complex symbolic stimuli will still give more rewarding results and that these new aspects of neurophysiology will help to put to a test various psychosomatic theories and hypotheses.
PEDAGOGICAL FALSE-POSITIVE TEST FOR SYPHILIS?
Authors: ALLAN LAWRENCE METZGER
Journal: Annals of Internal Medicine (1968)

Letters and Comments1 November 1968PEDAGOGICAL FALSE-POSITIVE TEST FOR SYPHILIS?ALLAN LAWRENCE METZGER, M.D.ALLAN LAWRENCE METZGER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-69-5-1075_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: In a recent Question of the Month (Rheumatology, Ann. Intern. Med. 68: 137, 1968) reference was made to the cause of a "biological false-positive test for syphilis" found in a "23-year-old asymptomatic woman as part of a premarital test." On the following four causal possibilities—systemic lupus erythematosus (SLE), subacute bacterial endocarditis, atypical pneumonia, and postnecrotic cirrhosis—the correct answer, as given in a subsequent issue of the ANNALS, was SLE and atypical pneumonia. This answer was obviously incomplete, as, in fact, all of the listed possibilities have been associated with the biological false-positive serology for syphilis (BFP).The... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ALLAN LAWRENCE METZGER, M.D.Affiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1968Volume 69, Issue 5Page: 1075-1076KeywordsBacterial pneumoniaEndocarditisLupus erythematosusPneumoniaRheumatologySerologySyphilis ePublished: 1 December 2008 Issue Published: 1 November 1968 PDF downloadLoading ...
Characterization of <i>Micropolyspora faeni</i> antigens by human antibodies and immunoblot analysis
Authors: M. Iranitalab, E. Jarolim, H. Rumpold, R. Steiner, H. Ebner, H. Feldner, O. Scheiner, D. Kraft
Journal: Allergy (1989)

IgG, IgM and IgA antibody responses against Micropolyspora faeni (Mf) antigens were studied by means of immunoblotting experiments using 70 sera derived from three groups of farmers, namely patients with extrinsic allergic alveolitis (EAA) due to thermophilic actinomycetes ( n = 25), patients without EAA but with hay exposure ( n = 14), and patients suspected to have EAA ( n = 31), and 27 sera from two groups of control persons (healthy laboratory workers, n = 13; healthy farmers, n = 14). Patients with EAA showed IgG, IgM and IgA antibody responses mainly against the antigens with molecular weights (MW) of 11, 12, 25, 35 and 60 kD (“major antigens”), and in addition, but less often, against six antigens with MW in the range of 15 to 62.5 kD (“minor antigens”). The other two groups of patients and also the exposed control persons showed very similar results; however, the antibody response in healthy farmers was substantially weaker in comparison to the three groups of patients and was almost limited to the major antigens with MW 11, 25 and 60 kD. Although patients with proven EAA had higher amounts of antibodies, there was no correlation between this antibody response and the onset of disease. The results indicate the necessity of including at least the major antigens with MW of 11, 25 and 60 kD in all extracts used for in vitro diagnosis of Mf ‐induced EAA.
The Ethics of Interrogation — The U.S. Military's Ongoing Use of Psychiatrists
Authors: Jonathan H. Marks, M. Gregg Bloche
Journal: New England Journal of Medicine (2008)

Jonathan Marks and Dr. M. Gregg Bloche write that the AMA and APA firmly oppose physicians' helping to devise interrogation plans for individual detainees. Yet documents recently provided by the U.S. Army make clear that the Department of Defense still wants doctors to be involved.
Local cutaneous sensitivity to subcutaneous heparin
Authors: S.C. Mayou, S.E. Kelly, D.H. McGibbon
Journal: British Journal of Dermatology (1987)

Journal Article Local cutaneous sensitivity to subcutaneous heparin Get access S.C. Mayou, S.C. Mayou The Dowling Skin Unit, St Thomas’Hospital, Lambeth Palace Road, London SE17EH, U.K. Search for other works by this author on: Oxford Academic Google Scholar S.E. Kelly, S.E. Kelly The Dowling Skin Unit, St Thomas’Hospital, Lambeth Palace Road, London SE17EH, U.K. Search for other works by this author on: Oxford Academic Google Scholar D.H. McGibbon D.H. McGibbon The Dowling Skin Unit, St Thomas’Hospital, Lambeth Palace Road, London SE17EH, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 117, Issue 5, 1 November 1987, Pages 664–665, https://doi.org/10.1111/j.1365-2133.1987.tb07502.x Published: 01 November 1987
Kif5B &amp; Ccdc6 Ret in Lung Cancer: Clinical Insights and Response to Personalized Based Therapy
Authors: M. Sarfaty, A. Moore, M. Gottfried, R. Katznelson, H. Nechushtan, M. Wolner, V. Neiman, L. Soussan-Gutman, A. Dvir, N. Peled
Journal: Annals of Oncology (2015)
Abstract 18: Deep-sequencing of ovarian cancer stem cells
Authors: Ahmet Zehir, Server Adil Ertem, Malcolm AS Moore
Journal: Cancer Research (2011)

Abstract Ovarian cancer remains to be one of the most fatal cancer types in women due to a lack of proper identification of therapies that will completely eradicate tumor cells in patients. Cancer stem cell (CSC) hypothesis states that there is a sub-population of cells in tumors that can self-renew and give rise to a differentiated tumor tissue. CSCs are also postulated to be resistant to conventional therapies, which might explain the recurrent nature of some of the cancer types. We have recently identified a novel cellular structure consisting of a chain of 4-72 cells with a pericellular glycocalyx, free-floating in the ascites of NOD/SCIDIL2Rγ-/- mice with intraperitoneal human serous ovarian adenocarcinoma (OvCa) xenografts. We have termed these “catenae” (Latin for “chains”). While the catena has the features of conventional CSCs, such as self-renewal, resistance to chemotherapy and ability to generate tumors in mice with as few as one cell; it also presents with unusual phenotypes. To elucidate the molecular mechanisms responsible for these phenotypes, as well as to get a transcriptional snapshot of pure CSCs; we performed SOLID deep-sequencing of catena on both whole cell RNA sample and polysomal RNA sample. We obtained 80millions and 60millions reads respectively. By comparing whole RNA sample to polysomal RNA sample, we have identified transcripts that are abundant in numbers but are not translated preferentially. We also identified alternative splicing events that might lead to the CSC phenotypes that catena have. Using public databases, we compared our data to differentiated cell states and generated comparative GO analysis of catena deep-sequencing data. The power of deep sequencing methodology will allow a deeper understanding of how CSCs might operate and will enable us to generate new therapies for eradicating CSCs. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 18. doi:10.1158/1538-7445.AM2011-18
Parkinson's Disease and its Management
Authors: R C Hughes
Journal: BMJ (1994)

Parkinson's disease and its various mimics occur in increasing numbers in our aging population, and the chronicity of the condition puts an ever growing demand on medical and social facilities.

For these reasons, together with the increasing number of drugs available and the fact that these are not always presented in a pharmacological order of merit, it is opportune that a small monograph such as Parkinson's Disease and its Management should become available.

Aimed …
Please do not resuscitate: Solution is flawed
Authors: Claud Regnard
Journal: BMJ (2006)

Solution is flawedEditor-Conroy et al offer a challenging solution to advance decisions on cardiopulmonary resuscitation (CPR), but the basis for that solution is fundamentally flawed. 1 They start from the premise that all institutions should provide cardiopulmonary resuscitation unless an overt decision has been made to the contrary. 2 3This is a common position in most UK NHS trusts, but there is no ethical, legal, or clinical demand on professionals that they must provide CPR.Current UK guidelines describe a presumption in favour of CPR in the absence of an advance decision but are equally clear that it would be unreasonable to resuscitate anyone in whom the burdens of treatment clearly outweigh the potential benefits.The presumption in favour of CPR has been interpreted by many health authorities as a default for CPR, but such a position is not supported by the guidelines and runs counter to personalised decision making by removing personal choice.It is also exceptional, since no other medical treatment comes with a default position.Unfortunately, Conroy et al's solution is to suggest an equally unacceptable position, a default against CPR.Conroy et al are right that the current guidelines need to be reviewed, but not for the reasons they state.Current UK guidelines are the source of much confusion among clinicians. 4They contain many contradictions and confusing statements and provide no framework for making clinical decisions.It is possible to make sense of advance decisions on CPR, and had the authors done so they would have arrived at a framework that individualises decisions, involves patients or relatives and partners when appropriate, and does so without placing an unnecessary burden on patients and carers. 4Instead the authors try to work through this confusion, and by offering a default against CPR they fail to reach a caring solution.
GMC launches consultation on details of revalidation
Authors: L. Eaton
Journal: BMJ (2010)

GPs in Wales could be among the first to be approved under the new process of revalidation of doctors, the chief executive of the General Medical Council has indicated.

Speaking to the BMJ before the launch of the GMC’s three month consultation on revalidation on 1 March, Niall Dickson said that GPs in Wales were “nearly there already,” with more than 90% of GPs already undergoing annual appraisal, which is being recorded by an integrated IT system.

“It’s probably the biggest change in medical legislation in 150 years,” said Mr Dickson, who added that in Wales the process of revalidation was “really quite well advanced.” 

“The extra bits that we will put in place will not throw …
1105 CYP2D6-PULSED SEMI-MATURE DENDRITIC CELLS ENHANCE ANTIGEN-SPECIFIC SUPPRESSOR FUNCTION OF CD4POS CD25POS T-REGS IN PATIENTS WITH AUTOIMMUNE HEPATITIS TYPE 2
Authors: M.S. Longhi, G. Mieli-Vergani, D. Vergani, Y. Ma
Journal: Journal of Hepatology (2010)
The value of quantitative measurement of HBeAg and HBsAg before interferon-α treatment of chronic hepatitis B in children
Authors: Barbara Burczynska, Kazimierz Madalinski, Joanna Pawlowska, Marek Woynarowski, Jerzy Socha, Wolfram H. Gerlich, Wulf R. Willems, Bogdan Wozniewicz, Józef Stachowski
Journal: Journal of Hepatology (1994)
Effect of Dominant Negative Transforming Growth Factor-β Receptor Type II on Cytotoxic Activity of RAW 264.7, a Murine Macrophage Cell Line
Authors: Geun Taek Lee, Jun Hyuk Hong, Cheol Kwak, Jaesung Woo, Victoria Liu, Chung Lee, Isaac Yi Kim
Journal: Cancer Research (2007)

Abstract Transforming growth factor-β (TGF-β) is a potent suppressor of the immune system. In the present study, we investigated the effect of TGF-β resistance on a murine macrophage cell line, RAW 264.7, by overexpressing a dominant negative TGF-β receptor type II (TβRIIDN) construct. As expected, TβRIIDN-expressing RAW cells, designated as RAW-TβRIIDN, were resistant to TGF-β signaling. When these cells were cocultured with the murine renal cell carcinoma cell line, Renca, a dramatic increase in apoptosis of Renca cells was observed. Simultaneously, elevated levels of inducible nitric oxide synthase (iNOS) and tumor necrosis factor-α (TNF-α) in association with IFN-γ were detected in RAW-TβRIIDN cells. When the effects of TNF-α and iNOS were neutralized through the use of neutralizing antibody and NG-methyl-l-arginine, respectively, the enhanced cytotoxicity of TβRIIDN-RAW cells was partially reversed. Taken together, these results show that TGF-β–resistant RAW 264.7 murine macrophage cells have increased cytotoxic activity that is in part mediated by iNOS and TNF-α. [Cancer Res 2007;67(14):6717–24]
Specific cell targeting with APRPG conjugated PEG–PLGA nanoparticles for treating ovarian cancer
Authors: Yunfei Wang, Peifeng Liu, Yourong Duan, Xia Yin, Qi Wang, Xiaofei Liu, Xinran Wang, Jinhua Zhou, Wenwen Wang, Lihua Qiu, Wen Di
Journal: Biomaterials (2013)
Unique Molecular Landscapes in Cancer: Implications for Individualized, Curated Drug Combinations
Authors: Jennifer Wheler, J. Jack Lee, Razelle Kurzrock
Journal: Cancer Research (2014)

With increasingly sophisticated technologies in molecular biology and "omic" platforms to analyze patients' tumors, more molecular diversity and complexity in cancer are being observed. Recently, we noted unique genomic profiles in a group of patients with metastatic breast cancer based on an analysis with next-generation sequencing. Among 57 consecutive patients, no two had the same molecular portfolio. Applied genomics therefore appears to represent a disruptive innovation in that it unveils a heterogeneity to metastatic cancer that may be ill-suited to canonical clinical trials and practice paradigms. Upon recognizing that patients have unique tumor landscapes, it is possible that there may be a "mismatch" between our traditional clinical trials system that selects patients based on common characteristics to evaluate a drug (drug-centric approach) and optimal treatment based on curated, individualized drug combinations for each patient (patient-centric approach).
Physical and biological studies of coal and oil fly ash.
Authors: G L Fisher, K L McNeill, B A Prentice, A R McFarland
Journal: Environmental Health Perspectives (1983)

Studies were performed to compare the physical and chemical characteristics and the in vitro macrophage cytotoxicity of oil and coal fly ash. Sampling methodology was developed to collect size-fractionated particulate matter from the smokestack of either a coal-fired or an oil-fired power plant. Morphological studies demonstrated particle heterogeneity, although most coal fly ash particles appeared to be spherical. Oil fly ash contained two major morphologies; nonopaque amorphous particles and opaque amorphous particles. Elemental analysis indicates that the coal ash is predominantly composed of aluminosilicate particles, while the oil ash is predominantly inorganic sulfates and carbonaceous particles. In vitro macrophage assays demonstrate that the finest coal fly ash particles are the most cytotoxic; the cytotoxicity is significantly less than that of alpha-quartz, the positive control particle. In contrast, the oil fly ash particles are more cytotoxic than quartz. The cytotoxicity of oil fly ash is due to soluble components, possibly vanadium salts.
A Job Well Done?
Authors: J. Randall Curtis
Journal: Annals of Internal Medicine (1991)

On Being a Doctor15 November 1991A Job Well Done?J. Randall Curtis, MDJ. Randall Curtis, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-115-10-823 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSitting here in the intensive care unit, waiting quietly while friends and family gather around the bedside to say their final good-byes to Paul, I find myself staring blankly out the window. The mechanical whir of the ventilator and the cold December rain on the window help me to drift peacefully back over the last two and a half years.Paul was 23 years old when he and I first met. It was a warm July day in Seattle. I was in the first month of my internship, and it was Paul's first visit to my clinic. He had been... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 November 1991Volume 115, Issue 10Page: 823-824KeywordsIntensive care unitsVentilators Issue Published: 15 November 1991 PDF DownloadLoading ...
'Old and Gray and Full of Sleep'? Not Always
Authors: Lynne Lamberg
Journal: JAMA (1997)

PERSISTENT MYTHS about sleep in late life may deter older adults from bringing sleep troubles to their physicians and physicians from pursuing often-remediable symptoms. It is not true, sleep specialists asserted in recent interviews, that: • poor sleep is an inevitable consequence of aging; • older people need less sleep; • daytime drowsiness and earlymorning awakenings are normal in later years; or • little can be done for menopauserelated sleep complaints. The afflictions that often accompany age are a bigger factor in troubled sleeping than old age itself, "not a subtle distinction," insisted Andrew Monjan, PhD, chief of the neurobiology of aging branch of the National Institute on Aging (NIA), Bethesda, Md. An NIA study, Monjan said, found that more than half of 9000 communityliving persons aged 65 years and older reported trouble in such areas as falling asleep or staying asleep, waking too early, needing to nap, and not
Treatment of Pancreatic Cancer With an Oncolytic Adenovirus Expressing Interleukin-12 in Syrian Hamsters
Authors: Sergia Bortolanza, Maria Bunuales, Itziar Otano, Gloria Gonzalez-Aseguinolaza, Carlos Ortiz-de-Solorzano, Daniel Perez, Jesus Prieto, Ruben Hernandez-Alcoceba
Journal: Molecular Therapy (2009)

Pancreatic cancer is an aggressive malignancy resistant to most conventional and experimental therapies, including conditionally replicative adenoviruses (CRAds). The incorporation of immunostimulatory genes such as interleukin-12 (IL-12) in these viruses may overcome some of their limitations, but evaluation of such vectors requires suitable preclinical models. We describe a CRAd in which replication is dependent on hypoxia-inducible factor (HIF) activity and alterations of the pRB pathway in cancer cells. Transgenes (luciferase or IL-12) were incorporated into E3 region of the virus using a selective 6.7K/gp19K deletion. A novel permissive model of pancreatic cancer developed in immunocompetent Syrian hamsters was used for in vivo analysis. We show that, in contrast with nonreplicating adenoviruses (NR-Ad), active viral production and enhanced transgene expression took place in vivo. A single intratumor inoculation of the CRAd expressing IL-12 (Ad-DHscIL12) achieved a potent antitumor effect, whereas higher doses of replication-competent adenoviruses carrying luciferase did not. Compared to a standard NR-Ad expressing IL-12, Ad-DHscIL12 was less toxic in hamsters, with more selective tumor expression and shorter systemic exposure to the cytokine. We conclude that the expression of IL-12 in the context of a hypoxia-inducible oncolytic adenovirus is effective against pancreatic cancer in a relevant animal model. Pancreatic cancer is an aggressive malignancy resistant to most conventional and experimental therapies, including conditionally replicative adenoviruses (CRAds). The incorporation of immunostimulatory genes such as interleukin-12 (IL-12) in these viruses may overcome some of their limitations, but evaluation of such vectors requires suitable preclinical models. We describe a CRAd in which replication is dependent on hypoxia-inducible factor (HIF) activity and alterations of the pRB pathway in cancer cells. Transgenes (luciferase or IL-12) were incorporated into E3 region of the virus using a selective 6.7K/gp19K deletion. A novel permissive model of pancreatic cancer developed in immunocompetent Syrian hamsters was used for in vivo analysis. We show that, in contrast with nonreplicating adenoviruses (NR-Ad), active viral production and enhanced transgene expression took place in vivo. A single intratumor inoculation of the CRAd expressing IL-12 (Ad-DHscIL12) achieved a potent antitumor effect, whereas higher doses of replication-competent adenoviruses carrying luciferase did not. Compared to a standard NR-Ad expressing IL-12, Ad-DHscIL12 was less toxic in hamsters, with more selective tumor expression and shorter systemic exposure to the cytokine. We conclude that the expression of IL-12 in the context of a hypoxia-inducible oncolytic adenovirus is effective against pancreatic cancer in a relevant animal model.