tbuckley/cabot-search huggingface dataset:
Gene expression profiling of Hfe-/- liver and duodenum in mouse strains with differing susceptibilities to iron loading: identification of transcriptional regulatory targets of Hfe and potential hemochromatosis modifiers
Authors: Hélène Coppin, Valérie Darnaud, Léon Kautz, Delphine Meynard, Marc Aubry, Jean Mosser, Maria Martinez, Marie-Paule Roth
Journal: Genome biology (2007)

Hfe disruption in mouse leads to experimental hemochromatosis by a mechanism that remains elusive. Affymetrix GeneChip Mouse Genome 430 2.0 microarrays and bioinformatics tools were used to characterize patterns of gene expression in the liver and the duodenum of wild-type and Hfe-deficient B6 and D2 mice (two inbred mouse strains with divergent iron loading severity in response to Hfe disruption), to clarify the mechanisms of Hfe action, and to identify potential modifier genes.We identified 1,343 transcripts that were upregulated or downregulated in liver and 370 in duodenum of Hfe-/- mice, as compared to wild-type mice of the same genetic background. In liver, Hfe disruption upregulated genes involved in antioxidant defense, reflecting mechanisms of hepatoprotection activated by iron overload. Hfe disruption also downregulated the expression of genes involved in fatty acid beta-oxidation and cholesterol catabolism, and of genes participating in mitochondrial iron traffic, suggesting a link between Hfe and the mitochondrion in regulation of iron homeostasis. These latter alterations may contribute to the inappropriate iron deficiency signal sensed by the duodenal enterocytes of these mice, and the subsequent upregulation of the genes encoding the ferrireductase Dcytb and several iron transporters or facilitators of iron transport in the duodenum. In addition, for several genes differentially expressed between B6 and D2 mice, expression was regulated by loci overlapping with previously mapped Hfe-modifier loci.The expression patterns identified in this study contribute novel insights into the mechanisms of Hfe action and potential candidate genes for iron loading severity.
Sustained expansion of NKT cells and antigen-specific T cells after injection of α-galactosyl-ceramide loaded mature dendritic cells in cancer patients
Authors: David H. Chang, Keren Osman, John Connolly, Anjli Kukreja, Joseph Krasovsky, Maggi Pack, Aisha Hutchinson, Matthew Geller, Nancy Liu, Rebecca Annable, Jennifer Shay, Kelly Kirchhoff, Nobusuke Nishi, Yoshitaka Ando, Kunihiko Hayashi, Hani Hassoun, Ralph M. Steinman, Madhav V. Dhodapkar
Journal: The Journal of Experimental Medicine (2005)

Natural killer T (NKT) cells are distinct glycolipid reactive innate lymphocytes that are implicated in the resistance to pathogens and tumors. Earlier attempts to mobilize NKT cells, specifically, in vivo in humans met with limited success. Here, we evaluated intravenous injection of monocyte-derived mature DCs that were loaded with a synthetic NKT cell ligand, α-galactosyl-ceramide (α-GalCer; KRN-7000) in five patients who had advanced cancer. Injection of α-GalCer–pulsed, but not unpulsed, dendritic cells (DCs) led to &amp;gt;100-fold expansion of several subsets of NKT cells in all patients; these could be detected for up to 6 mo after vaccination. NKT activation was associated with an increase in serum levels of interleukin-12 p40 and IFN-γ inducible protein-10. In addition, there was an increase in memory CD8+ T cells specific for cytomegalovirus in vivo in response to α-GalCer–loaded DCs, but not unpulsed DCs. These data demonstrate the feasibility of sustained expansion of NKT cells in vivo in humans, including patients who have advanced cancer, and suggest that NKT activation might help to boost adaptive T cell immunity in vivo.
Progress report of combined chemoradiotherapy versus radiotherapy alone in patients with esophageal cancer: an intergroup study.
Authors: M al-Sarraf, K Martz, A Herskovic, L Leichman, J S Brindle, V K Vaitkevicius, J Cooper, R Byhardt, L Davis, B Emami
Journal: Journal of Clinical Oncology (1997)

PURPOSE The present intergroup phase III randomized study compared combined chemotherapy (CT) plus radiotherapy (RT) treatment versus RT only in patients with locally advanced esophageal cancer. MATERIALS AND METHODS Two courses of chemotherapy during 50 Gy RT followed by additional two courses of the same CT, versus 64 Gy RT alone were investigated. CT consisted of cisplatin 75 mg/m2 on day 1 [corrected] and fluorouracil (5FU) 1,000 mg/m2/d on days 1 to 4 every 4 weeks with RT and every 3 weeks post-RT. The main objective of the study was to compare overall survival between the two randomized treatment groups. Patients were stratified by tumor size, histology, and degree of weight loss. RESULTS Sixty-two assessable patients were randomized to receive RT alone, and 61 to the combined arm. Patients characteristics were as follows: squamous cell cancer, 90% versus 85%; weight loss greater than 10 lb, 61% versus 69%; and tumor size, &gt; or = 5 cm, 82% versus 80% on the RT and CT-RT arms, respectively. Systemic side effects, which consisted of nausea, vomiting, and renal and myelosuppression, occurred more frequently on the combined arm, while local side effects were similar in both groups. With a minimum follow-up time of 5 years for all patients, the median survival duration was 14.1 months and the 5-year survival rate was 27% in the combined treatment group, while the median survival duration was 9.3 months with no patients alive at 5 years in the RT-alone group (P &lt; .0001). Additional patients (69) were treated with the same combined therapy and were analyzed. The results of the last group confirmed all of the results obtained with combined CT-RT in the randomized trial, with a median survival duration of 17.2 months and 3-year survival rate of 30%. CONCLUSION We conclude that cisplatin and 5FU infusion given during and post-RT of 50 Gy is statistically superior to standard 64-Gy RT alone in patients with locally advanced esophageal cancer.
Is There A Specific Profile Of Patients With Persistent Ige-mediated Cow'S Milk Allergy?
Authors: C.M.A. Jacob, C.L. Oliveira, A.C. Pastorino, A.C. Goldberg, T.S. Okay, A.B.F. Fomin, L.A. Watanabe, V.C.Z. Fucci, A.K.F. Gushken, U. Doria, C.A. Silva, A.P.B.M. Castro
Journal: Journal of Allergy and Clinical Immunology (2010)
THE DIAGNOSIS OF EARLY PULMONARY TUBERCULOSIS
Authors: W. B. Wood
Journal: BMJ (1935)

THE STREPTOCOCCAL DERMATOSES TMEABRITISR This should be well rubbed into the scalp, left for a few minutes, and then rinsed off with water.If there is any sign of increase in the irritation the shampooing should-be stopped and the poultices resumed.Where the body is extensively involved, and for the folds such as the axillae or groins, the application of a calamine cream, slightly carbolized, is often advantageous-for example: Preparad calamine ... .
Assessing Exposure to Toxic Gases in Bhopal
Authors: V. Ramana Dhara
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Multicenter phase III trial to evaluate CD34(+) selected versus unselected autologous peripheral blood progenitor cell transplantation in multiple myeloma.
Authors: Robert Vescio, Gary Schiller, A. Keith Stewart, Oscar Ballester, Stephen Noga, Hope Rugo, Cesar Freytes, Edward Stadtmauer, Stefano Tarantolo, Firoozeh Sahebi, Pat Stiff, Jacinta Meharchard, Robert Schlossman, Randy Brown, Heather Tully, Mark Benyunes, Cindy Jacobs, Ronald Berenson, John DiPersio, Ken Anderson, James Berenson
Journal: Blood (1999)
Nonatheromatous Arterial Thrombosis
Authors: A I Schafer, M H Kroll
Journal: Annual Review of Medicine (1993)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19), emerged in China in December 2019 and quickly spread around the globe, killing more than 4 million people and causing a severe economic crisis. ...Read More
Epstein-Barr Virus–Induced Secondary High-Grade Transformation of Sjögren's Syndrome–Related Mucosa-Associated Lymphoid Tissue Lymphoma
Authors: Julia Elise Strunk, Christian Schüttler, John Ziebuhr, Michael Stowasser, Matthias Nöhte, Konstantin Mayer, Andreas Bräuninger, Stefan Gattenlöhner
Journal: Journal of Clinical Oncology (2013)
Nickel-responding T cells are CD4+ CLA+ CD45RO+ and express chemokine receptors CXCR3, CCR4 and CCR10
Authors: H. Moed, D.M. Boorsma, T.J. Stoof, B.M.E. Von Blomberg, D.P. Bruynzeel, R.J. Scheper, S. Gibbs, T. Rustemeyer
Journal: British Journal of Dermatology (2004)

Journal Article Nickel‐responding T cells are CD4+ CLA+ CD45RO+ and express chemokine receptors CXCR3, CCR4 and CCR10 Get access H. Moed, H. Moed Departments of Dermatology and Pathology, VU University Medical Centre, PO Box 7057, 1007 MB Amsterdam, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar D.M. Boorsma, D.M. Boorsma Departments of Dermatology and Pathology, VU University Medical Centre, PO Box 7057, 1007 MB Amsterdam, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar T.J. Stoof, T.J. Stoof Departments of Dermatology and Pathology, VU University Medical Centre, PO Box 7057, 1007 MB Amsterdam, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar B.M.E. Von Blomberg, B.M.E. Von Blomberg Departments of Dermatology and Pathology, VU University Medical Centre, PO Box 7057, 1007 MB Amsterdam, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar D.P. Bruynzeel, D.P. Bruynzeel Departments of Dermatology and Pathology, VU University Medical Centre, PO Box 7057, 1007 MB Amsterdam, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar R.J. Scheper, R.J. Scheper Departments of Dermatology and Pathology, VU University Medical Centre, PO Box 7057, 1007 MB Amsterdam, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar S. Gibbs, S. Gibbs Departments of Dermatology and Pathology, VU University Medical Centre, PO Box 7057, 1007 MB Amsterdam, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar T. Rustemeyer T. Rustemeyer Departments of Dermatology and Pathology, VU University Medical Centre, PO Box 7057, 1007 MB Amsterdam, The Netherlands T.Rustemeyer. E‐mail: t.rustemeyer@vumc.nl Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 151, Issue 1, 1 July 2004, Pages 32–41, https://doi.org/10.1111/j.1365-2133.2004.05975.x Published: 01 July 2004 Article history Accepted: 15 December 2003 Published: 01 July 2004
Bronchogenic cysts: clinicopathological presentation and treatment
Authors: S Aktogu, G Yuncu, H Halilcolar, S Ermete, T Buduneli
Journal: European Respiratory Journal (1996)

The aim of this study was to evaluate the preoperative and operative presentations of one paediatric and 30 adult patients with bronchogenic cyst of the mediastinum (n = 11) and lung (n = 20). At initial presentation, six patients were asymptomatic and 25 were symptomatic. The mean age of asymptomatic and symptomatic patients was 25 and 33 yrs, respectively. Six patients presented with complications, including superior vena cava syndrome, tracheal compression, pneumothorax, pleurisy and pneumonia. Two patients who were asymptomatic when initially observed eventually needed surgery because of the development of symptoms or enlargement of the cyst size. In one patient, the cyst was not seen on the chest radiograph but appeared as a lobulated nodule of 2 cm diameter in a chest computerized tomography (CT) scan. Operative difficulties were encountered in 13 patients, all of whom were symptomatic preoperatively. In conclusion, life-threatening complications occurred in these patients. Despite various diagnostic studies, definitive tissue diagnosis was established only by means of surgical excision. The frequency of operative difficulties in symptomatic cysts was higher than those of asymptomatic cysts. Surgery may be considered as the treatment of choice even when the cyst is asymptomatic, since complications are not uncommon.
Neurobiological Mechanisms of Social Anxiety Disorder
Authors: Sanjay J. Mathew, Jeremy D. Coplan, Jack M. Gorman
Journal: American Journal of Psychiatry (2001)

OBJECTIVE: The authors critically surveyed several preclinical and clinical neurobiological models of social anxiety disorder. METHOD: The authors reviewed the recent literature regarding three animal models of particular relevance to social anxiety. They then examined the recent literature concerning clinical neurobiological aspects of social anxiety disorder, including the developmental neurobiology of anxiety, the genetics of fear and social anxiety, and challenge and imaging studies. RESULTS: The available animal models are useful paradigms for understanding the features of social subordination stress, attachment behavior, and environmental rearing, but they incompletely account for the known neurobiology of human social anxiety disorder. The clinical neurobiology literature surveyed implicates specific neurotransmitter system abnormalities, most notably of the dopamine system, but largely ignores neurodevelopmental processes and the functional interactions between neurotransmitters. Both heritable factors and environmental stress factors appear to be responsible for the onset of social anxiety disorder. CONCLUSIONS: Social anxiety disorder should be conceptualized as a chronic neurodevelopmental illness that might represent a fully compensated state in adulthood. Future investigations from this perspective are discussed.
Misregulation of Pre-mRNA Alternative Splicing in Cancer
Authors: Jian Zhang, James L. Manley
Journal: Cancer Discovery (2013)

Alternative splicing of mRNA precursors enables one gene to produce multiple protein isoforms with differing functions. Under normal conditions, this mechanism is tightly regulated in order for the human genome to generate proteomic diversity sufficient for the functional requirements of complex tissues. When deregulated, however, cancer cells take advantage of this mechanism to produce aberrant proteins with added, deleted, or altered functional domains that contribute to tumorigenesis. Here, we discuss aspects of alternative splicing misregulation in cancer, focusing on splicing events affected by deregulation of regulatory splicing factors and also recent studies identifying mutated components of the splicing machinery.An increasing body of evidence indicates that aberrant splicing of mRNA precursors leads to production of aberrant proteins that contribute to tumorigenesis. Recent studies show that alterations in cellular concentrations of regulatory splicing factors and mutations in components of the core splicing machinery provide major mechanisms of misregulation of mRNA splicing in cancer. A better understanding of this misregulation will potentially reveal a group of novel drug targets for therapeutic intervention.
The impact of altitude on the sleep of young elite soccer players (ISA3600)
Authors: Charli Sargent, Walter F Schmidt, Robert J Aughey, Pitre C Bourdon, Rudy Soria, Jesus C Jimenez Claros, Laura A Garvican-Lewis, Martin Buchheit, Ben M Simpson, Kristal Hammond, Marlen Kley, Nadine Wachsmuth, Christopher J Gore, Gregory D Roach
Journal: British Journal of Sports Medicine (2013)

Altitude training is used by elite athletes to improve sports performance, but it may also disrupt sleep. The aim of this study was to examine the effects of 2 weeks at high altitude on the sleep of young elite athletes.Participants (n=10) were members of the Australian under-17 soccer team on an 18-day (19-night) training camp in Bolivia, with six nights at near sea level in Santa Cruz (430 m) and 13 nights at high altitude in La Paz (3600 m). Sleep was monitored using polysomnography during a baseline night at 430 m and three nights at 3600 m (immediately after ascent, 1 week after ascent and 2 weeks after ascent). Data were analysed using effect size statistics.All results are reported as comparisons with baseline. Rapid eye movement (REM) sleep was likely lower immediately upon ascent to altitude, possibly lower after 1 week and similar after 2 weeks. On all three nights at altitude, hypopneas and desaturations were almost certainly higher; oxygen saturation was almost certainly lower; and central apnoeas, respiratory arousals and periodic breathing were very likely higher. The effects on REM sleep were common to all but one participant, but the effects on breathing were specific to only half the participants.The immediate effects of terrestrial altitude of 3600 m are to reduce the amount of REM sleep obtained by young elite athletes, and to cause 50% of them to have impaired breathing during sleep. REM sleep returns to normal after 2 weeks at altitude, but impaired breathing does not improve.
Delivery of Telomerase Reverse Transcriptase Small Interfering RNA in Complex with Positively Charged Single-Walled Carbon Nanotubes Suppresses Tumor Growth
Authors: Zhuohan Zhang, Xiaoying Yang, Yuan Zhang, Bin Zeng, Shujing Wang, Tianhui Zhu, Richard B.S. Roden, Yongsheng Chen, Rongcun Yang
Journal: Clinical Cancer Research (2006)

Abstract Purpose: To determine whether -CONH-(CH2)6-NH3+Cl− functionalized single-walled carbon nanotubes (SWNT) carrying complexed small interfering RNA (siRNA) can enter into tumor cells, wherein they release the siRNA to silence the targeted gene. Experimental Design: -CONH-(CH2)6-NH3+Cl− was used to mediate the conjugation of telomerase reverse transcriptase (TERT) siRNA to SWNTs. The ability of TERT siRNA delivered via SWNT complexes to silence the expression of TERT was assessed by their effects on the proliferation and growth of tumor cells both in vitro and in mouse models. Results: The functionalized SWNTs -CONH-(CH2)6-NH3+Cl− could facilitate the coupling of siRNAs that specifically target murine TERT expression to form the mTERT siRNA:SWNT+ complex. These functionalized SWNTs rapidly entered three cultured murine tumor cell lines, suppressed mTERT expression, and produced growth arrest. Injection of mTERT siRNA:SWNT+ complexes into s.c. Lewis lung tumors reduced tumor growth. Furthermore, human TERT siRNA:SWNT+ complexes also suppressed the growth of human HeLa cells both in vitro and when injected into tumors in nude mice. Conclusions: -CONH-(CH2)6-NH3+Cl− functionalized SWNTs carry complexed siRNA into tumor cells, wherein they release the siRNA from the nanotube sidewalls to silence the targeted gene. The -CONH-(CH2)6-NH3+Cl− functionalized SWNTs may represent a new class of molecular transporters applicable for siRNA therapeutics.
Preventing Pressure Ulcers: A Systematic Review
Authors: Madhuri Reddy, Sudeep S. Gill, Paula A. Rochon
Journal: JAMA (2006)

ContextPressure ulcers are common in a variety of patient settings and are associated with adverse health outcomes and high treatment costs.ObjectiveTo systematically review the evidence examining interventions to prevent pressure ulcers.Data Sources and Study SelectionMEDLINE, EMBASE, and CINAHL (from inception through June 2006) and Cochrane databases (through issue 1, 2006) were searched to identify relevant randomized controlled trials (RCTs). UMI Proquest Digital Dissertations, ISI Web of Science, and Cambridge Scientific Abstracts were also searched. All searches used the terms pressure ulcer, pressure sore, decubitus, bedsore, prevention, prophylactic, reduction, randomized, and clinical trials. Bibliographies of identified articles were further reviewed.Data SynthesisFifty-nine RCTs were selected. Interventions assessed in these studies were grouped into 3 categories, ie, those addressing impairments in mobility, nutrition, or skin health. Methodological quality for the RCTs was variable and generally suboptimal. Effective strategies that addressed impaired mobility included the use of support surfaces, mattress overlays on operating tables, and specialized foam and specialized sheepskin overlays. While repositioning is a mainstay in most pressure ulcer prevention protocols, there is insufficient evidence to recommend specific turning regimens for patients with impaired mobility. In patients with nutritional impairments, dietary supplements may be beneficial. The incremental benefit of specific topical agents over simple moisturizers for patients with impaired skin health is unclear.ConclusionsGiven current evidence, using support surfaces, repositioning the patient, optimizing nutritional status, and moisturizing sacral skin are appropriate strategies to prevent pressure ulcers. Although a number of RCTs have evaluated preventive strategies for pressure ulcers, many of them had important methodological limitations. There is a need for well-designed RCTs that follow standard criteria for reporting nonpharmacological interventions and that provide data on cost-effectiveness for these interventions.
Collagenase Total Occlusion-1 (CTO-1) Trial
Authors: Bradley H. Strauss, Azriel B. Osherov, Sam Radhakrishnan, G.B. John Mancini, Allison Manners, John D. Sparkes, Robert J. Chisholm
Journal: Circulation (2011)

Percutaneous interventions for chronic total occlusions have low success rates, primarily because of failure of guide wire crossing. Collagen-rich matrix constitutes the main barrier to chronic total occlusion crossing. In preclinical studies, local delivery of a bacterial collagenase formulation improved guide wire crossing. The Collagenase Total Occlusion-1 (CTO-1) Trial is a phase I, dose-escalation trial to assess the safety and efficacy of collagenase therapy to facilitate guide wire crossing in coronary artery chronic occlusions.Twenty subjects with ≥1 previous failure of chronic total occlusion guide wire crossing were enrolled at 2 sites. Subjects were treated in 4 distinct cohorts of 5 patients, with escalation of collagenase dose in each cohort from 300 to 1200 μg. Collagenase was locally delivered into the occlusions with either an over-the-wire balloon system (n=8) or a fine-cross microcatheter (n=12) for a period of 30 minutes. Subjects were brought back to the catheterization laboratory for guide wire crossing and angioplasty the next day. Guide wire crossing was successfully achieved in 15 subjects (75%). A soft-tip guide wire (Whisper, Pilot-50, Fielder XT) was either the sole or predominant guide wire used in 75% of successful crossings. Non-ST-segment-elevation myocardial infarctions occurred in 3 patients as a result of side-branch ischemia during stenting. Computed tomographic angiography at 3 months showed no late complications and patent stents in successfully treated chronic total occlusion. Anginal improvement occurred with a reduction in Canadian Cardiovascular Society class from baseline to 3 months (2.5±0.6 versus 0.9±0.9; P<0.001).Local delivery of collagenase into coronary chronic total occlusion is feasible and safe with encouraging guide wire crossing results in previously failed cases. Larger clinical trials are required to determine efficacy.URL: http://www.clinicaltrials.gov. Unique identifier: NCT01271335.