tbuckley/cabot-search huggingface dataset:
Impact of malignant stem cell burden on therapy outcome in newly diagnosed chronic myeloid leukemia patients
Authors: S Mustjoki, J Richter, G Barbany, H Ehrencrona, T Fioretos, T Gedde-Dahl, B T Gjertsen, R Hovland, S Hernesniemi, D Josefsen, P Koskenvesa, I Dybedal, B Markevärn, T Olofsson, U Olsson-Strömberg, K Rapakko, S Thunberg, L Stenke, B Simonsson, K Porkka, H Hjorth-Hansen
Journal: Leukemia (2013)
Abstract A27: Expression of the EGFR suppressor LRIG1 is associated with survival in non-small cell lung cancer
Authors: Samue Kvarnbrink, Karolina Edlund, Johan Botling, Patrick Micke, Håkan Hedman, Mikael Johansson
Journal: Clinical Cancer Research (2012)

Abstract Leucine-rich repeats and immunoglobulin-like domains (LRIG)-1 is an endogenous inhibitor of epidermal growth factor receptor (EGFR) signaling, that is down-regulated in several forms of human cancer. The LRIG gene family also includes LRIG2 and LRIG3. EGFR signaling is important in non-small cell lung cancer (NSCLC) and EGFR tyrosine kinase inhibitors are today considered standard treatment in patients with advanced disease. Since smoking recently was reported to down-regulate LRIG1 gene expression in lung epithelium and squamous cell carcinoma of the lung, the LRIG family of proteins may be important in lung cancer. The objective of the present study was to investigate if LRIG is a prognostic factor in non-small cell lung cancer (NSCLC). Therefore, we conducted an in silico analysis of LRIG gene expression in publicly available datasets using the Oncomine database and compared LRIG expression to clinical outcome. We also analyzed the LRIG protein expression by immunohistochemistry in a tissue micro array (TMA, n = 190) representing long- and short time survivors from a surgically treated NSCLC patient cohort. In seven out of 11 datasets in the in silico analysis, high expression of LRIG1 correlated (p&amp;lt;0.05) with long patient survival. This correlation was apparent both in adenocarcinoma and squamous cell carcinoma. In the TMA, LRIG1 expression was significantly higher in the long-term survival group than in the short time survival group (p&amp;lt;0.05). LRIG2 and LRIG3 protein expression did not significantly correlate to survival. In conclusion, both our in silico analysis of gene expression and TMA study of protein expression showed associations between high LRIG1 expression and longer NSCLC patient survival. This implicates that LRIG1 may be a prognostic factor in NSCLC and further studies on larger datasets have been initiated.
The CC chemokine receptor 3 is essential for skin eosinophilia and for airway hyper-responsiveness to inhaled antigen in a murine model of allergic skin inflammation
Authors: Weilie Ma, Paul J Bryce, Alison Humbles, Dhafer Laouini, Ali Yalcindag, Harri Tapio Alenius, Daniel Friend, Hans C Oettgen, Craig Gerard, Raif S Geha
Journal: Journal of Allergy and Clinical Immunology (2002)
Contradicted and Initially Stronger Effects in Highly Cited Clinical Research
Authors: John P. A. Ioannidis
Journal: JAMA (2005)

Controversy and uncertainty ensue when the results of clinical research on the effectiveness of interventions are subsequently contradicted. Controversies are most prominent when high-impact research is involved.To understand how frequently highly cited studies are contradicted or find effects that are stronger than in other similar studies and to discern whether specific characteristics are associated with such refutation over time.All original clinical research studies published in 3 major general clinical journals or high-impact-factor specialty journals in 1990-2003 and cited more than 1000 times in the literature were examined.The results of highly cited articles were compared against subsequent studies of comparable or larger sample size and similar or better controlled designs. The same analysis was also performed comparatively for matched studies that were not so highly cited.Of 49 highly cited original clinical research studies, 45 claimed that the intervention was effective. Of these, 7 (16%) were contradicted by subsequent studies, 7 others (16%) had found effects that were stronger than those of subsequent studies, 20 (44%) were replicated, and 11 (24%) remained largely unchallenged. Five of 6 highly-cited nonrandomized studies had been contradicted or had found stronger effects vs 9 of 39 randomized controlled trials (P = .008). Among randomized trials, studies with contradicted or stronger effects were smaller (P = .009) than replicated or unchallenged studies although there was no statistically significant difference in their early or overall citation impact. Matched control studies did not have a significantly different share of refuted results than highly cited studies, but they included more studies with "negative" results.Contradiction and initially stronger effects are not unusual in highly cited research of clinical interventions and their outcomes. The extent to which high citations may provoke contradictions and vice versa needs more study. Controversies are most common with highly cited nonrandomized studies, but even the most highly cited randomized trials may be challenged and refuted over time, especially small ones.
Liver stiffness is directly influenced by central venous pressure
Authors: Gunda Millonig, Stefanie Friedrich, Stefanie Adolf, Hamidreza Fonouni, Mohammad Golriz, Arianeb Mehrabi, Peter Stiefel, Gudrun Pöschl, Markus W. Büchler, Helmut Karl Seitz, Sebastian Mueller
Journal: Journal of Hepatology (2009)
Chilling away the pain of vascular headache
Authors: John Elliott
Journal: JAMA (1979)

Physicians faced with patient complaints about the often intolerable pain of vascular headache, whether migraine, cluster, or a combination of the two, will be interested in a progress report from the field of cryosurgery. Cryotherapy for vascular headache, consisting of freezing of various parts of the sphenopalatine ganglion region, was first shown to be effective in 1962. Since that time the technique has been shown to provide only temporary relief from pain (lasting from two to five years) and to be effective only in selected patients. Today these limitations remain, but refinements in the technique promise considerable relief for some sufferers. In a report to the recent annual meeting of the American College of Cryosurgery at Grand Island, NY, James Ozenberger, MD, past president of the group and assistant clinical professor of surgery at Yale University School of Medicine, described a follow-up study on his most recent series of headache
Abstract 3938: Role of Chi3l1/YKL-40 in the tumor progression and metastasis in the lung.
Authors: Chun Geun Lee, Bing Ma, Ja Seok Koo, Roy S. Herbst, Jack A. Elias
Journal: Cancer Research (2013)

Abstract The 18 glycosyl hydrolase gene family (GH18) contains chitinases and chitinase-like proteins (CLP) that lack enzyme activity. Chitinase 3-like-1 (Chi3l1; also called BRP-39 in mouse and YKL-40 in man), the prototypic CLP, is expressed in an exaggerated fashion in the serum and or tissues from patients with a variety of malignancies including breast, colon/rectum, ovary, melanoma, prostate, kidney, brain, bone, and lung. In many of these malignancies, there is a strong correlation between the levels of Chi3l1/YKL-40 and disease progression, prognosis and disease-free survival. However, the roles of YKL-40 in the development and progression of lung cancer has not been determined. To begin to address this issue, we generated Chi3l1/BRP-39 null mutant (Chi3l1-/-) and lung-specific overexpressing YKL-40 transgenic (YKL-40 Tg) mice and evaluated them in a number of settings. The studies demonstrated that Chi3l1/BRP-39/YKL-40 is an important regulator of cellular apoptosis, inflammation, angiogenesis and M2 macrophage differentiation. We also found that melanoma metastasis to the lung was significantly decreased in Chi3l1-/- mice and increased in YKL-40 Tg mice and that activation of the RIG-like helicase (RLH) innate immune pathway significantly decreased BRP-39 production and melanoma or breast cancer lung metastasis. Lastly, immunohistochemical (IHC) analysis demonstrated that, in mice with specific mutation of KRAS and/or p53, Chi3l1/BRP-39 is expressed in an exaggerated manner in normal peritumor tissues and lung cancer cells in early and late stages of lung cancer development, respectively. In combination, our preliminary studies demonstrate that Chi3l1/BRP-39/YKL-40 plays a critical role in the generation of a metastasis-permissive microenvironment and is dysregulated in the course of the development of primary lung cancers. Citation Format: Chun Geun Lee, Bing Ma, Ja Seok Koo, Roy S. Herbst, Jack A. Elias. Role of Chi3l1/YKL-40 in the tumor progression and metastasis in the lung. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3938. doi:10.1158/1538-7445.AM2013-3938
The Temporomandibular Syndrome
Authors: Charles S. Greene
Journal: JAMA (1973)

Patients with facial pain frequently consult physicians or dentists, or both, about their problems. Sometimes the diagnosis can be made easily, as in cases of obvious otitis, sinusitis, or dental abscess. Other conditions, however, can be considerably more difficult to identify or to manage. One such condition is the temporomandibular joint (TMJ) pain-dysfunction syndrome, which has been described extensively in the medical and dental literature over the past 40 years. Yet, a recent survey published in the<i>Journal of the American Dental Association</i><sup>1</sup>showed that many physicians and dentists still are either uninformed about the syndrome, or they are following outdated concepts of diagnosis and treatment for TMJ problems. In fact, a substantial number of practitioners in both professions did not even acknowledge the existence of a TMJ pain-dysfunction syndrome. In the survey, which included a random group of physicians and a sampling of members of the American Association
Addressing the ‘postcode lottery’ in local resource allocation decisions: a framework for clinical commissioning groups
Authors: Jill Russell, Trisha Greenhalgh, Harriet Lewis, Ian Mackenzie, Neal Maskrey, Jonathan Montgomery, Claire O'Donnell
Journal: Journal of the Royal Society of Medicine (2013)

The NHS Constitution emphasizes patients’ rights to expect these decisions to be made ‘rationally’. The National Prescribing Centre (NPC), now the Medicines and Prescribing Centre at the National Institute for Health and Clinical Excellence, has directed considerable effort in recent years at defining the parameters of rational decisionmaking, and supporting PCTs in improving their approaches to prioritization and resource allocation. The NPC, commissioned by the Department of Health, embarked on a systematic process to develop a national ‘competency framework’ resource for those involved in making difficult prioritization decisions at a local level.This paper reports on how the NPC competency framework was developed, and presents a potentially transferable methodology for advancing a competency framework to support individual and organizational learning and improvement
New guidance issued on promoting integrity in scientific research
Authors: C. White
Journal: BMJ (2002)

Strong institutional leadership, ongoing self assessment, and comprehensive training in ethics are critical to fostering a national climate in which scientific research integrity can flourish, concludes a US report.

The report, by the Committee on Assessing Integrity in Research Environments, was prompted by the US Office of Research Integrity (ORI), which monitors and regulates research misconduct.

The annual ORI review for 2001 reported the highest number of misconduct cases since 1977. Among the 78 reporting institutions, 61 opened 72 new cases to look into …
Fried foods and the risk of coronary heart disease
Authors: M. F. Leitzmann, T. Kurth
Journal: BMJ (2012)

Cancer-associated fibroblasts that overexpress fibroblast activation protein (FAP) are enriched in many epithelial carcinomas and in hematologic neoplasms. PET/CT with radiolabeled FAP inhibitor (FAPI) is a new diagnostic tool for visualizing the tumor stroma. This prospective study aimed to profile FAPs in different subtypes of lymphomas and explore the potential utility of <sup>68</sup>Ga-FAPI PET/CT in lymphomas. <b>Methods:</b> In this prospective study, we recruited 73 lymphoma patients who underwent <sup>68</sup>Ga-FAPI PET/CT and recorded and measured semiquantitative parameters and ratios of their scan results. FAPI expression was assessed by immunochemistry in samples obtained from 22 of the lymphoma patients. <b>Results:</b> We evaluated 11 patients with Hodgkin lymphoma and 62 with non-Hodgkin lymphoma (NHL). Significantly elevated FAP uptake was observed in Hodgkin lymphoma lesions, correlating with the intensity of FAP immunostaining (score, 3+). A positive association was found between the corresponding clinical classification of NHL and the <sup>68</sup>Ga-FAPI uptake activity of the lesion. Aggressive NHL lesions, with moderate to strong FAP immunostaining (score, 2+ to 3+), exhibited intense to moderate <sup>68</sup>Ga-FAPI uptake. Indolent NHL lesions showed weak FAP staining and mild to moderate <sup>68</sup>Ga-FAPI uptake. No statistically significant correlation emerged between the sum of the product of the diameters and the corresponding SUV<sub>max</sub> (<i>P</i> = 0.424). The tumor-to-liver ratios were 6.26 ± 4.17 in indolent NHL and more than 9 in other subtypes. <b>Conclusion:</b><sup>68</sup>Ga-FAPI imaging can be used to detect FAP expression in lymphoma lesions and may be an alternate method for characterizing lymphoma profiles.
The Effectiveness of Home Care for General Hospital Patients
Authors: Joseph R. Stone
Journal: JAMA (1968)

A random group of 175 nonindigent patients were placed in home care and the end results of their treatment were compared to those of a balanced control group of 85 patients retained in a general hospital. Follow-up study of patients revealed that end results of care for the two groups of patients were not significantly different regardless of the mode of care. Neither diagnosis nor prognosis made a significant difference in the end results for patients receiving either mode of care, indicating the acceptability of home care as an alternate to continued hospitalization. Patients and physicians strongly preferred home care, and it proved economically feasible for a private medical insurance carrier to provide coverage.
Sensitive cardiac troponin assays were more accurate than a standard troponin assay for early diagnosis of AMI
Authors: Michelle Welsford
Journal: Annals of Internal Medicine (2009)

ACP Journal Club15 December 2009Sensitive cardiac troponin assays were more accurate than a standard troponin assay for early diagnosis of AMIMichelle Welsford, MD, ABEMMichelle Welsford, MD, ABEMMcMaster University, Hamilton, Ontario, Canada (M.W.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-151-12-200912150-02012 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationReichlin T, Hochholzer W, Bassetti S, et al. Early diagnosis of myocardial infarction with sensitive cardiac troponin assays. N Engl J Med. 2009;361:858-67. https://pubmed.ncbi.nlm.nih.gov/19710484Clinical Impact RatingsEmergency Med: Cardiology: References1 Thygesen K, Alpert JS, White HD, et al. Universal definition of myocardial infarction. Circulation. 2007;116:2634-53. [PMID: 17951284] Google Scholar2 Keller T, Zeller T, Peetz D, et al. Sensitive troponin I assay in early diagnosis of acute myocardial infarction. N Engl J Med. 2009;361:868-77. [PMID: 19710485] Google Scholar Author, Article, and Disclosure InformationAffiliations: McMaster University, Hamilton, Ontario, Canada (M.W.)This article was published at Annals.org on 1 December 2009. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 December 2009Volume 151, Issue 12Page: JC6-12KeywordsIschemiaMedical dialysisMyocardial infarctionSpecificityTroponin ePublished: 15 December 2009 Issue Published: 15 December 2009 Copyright & PermissionsCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Induction of B7-H6, a ligand for the natural killer cell–activating receptor NKp30, in inflammatory conditions
Authors: Jessica Matta, Myriam Baratin, Laurent Chiche, Jean-Marie Forel, Céline Cognet, Guillemette Thomas, Catherine Farnarier, Christelle Piperoglou, Laurent Papazian, Damien Chaussabel, Sophie Ugolini, Frédéric Vély, Eric Vivier
Journal: Blood (2013)
Health at Older Ages: The Causes and Consequences of Declining Disability Among the Elderly
Authors: A. Mark Clarfield
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 202: Endogenous c-jun inhibits mammary epithelial cellular apoptosis <i>in vivo</i>
Authors: Sanjay Katiyar, Mathew Casimiro, Luis Dettin, Xiaoming Ju, Erwin Wagner, Hirokazu Tanaka, Richard Pestell
Journal: Cancer Research (2011)

Abstract c-jun, which is overexpressed in a number of human cancers encodes a critical component of the AP-1 complex. c-jun has been shown to either induce or inhibit cellular apoptosis. Germ line deletion of both c-jun alleles is embryonically lethal. To determine the role of the endogenous c-jun gene in apoptosis, we performed mammary epithelial cell-targeted somatic deletion using floxed c-jun (c-jun f/f) conditional knockout mice. Laser capture microdissection demonstrated endogenous c-jun inhibits expression of apoptosis inducing genes and reactive oxygen species (ROS)-reducing genes (MnSOD, catalase). ROS have been implicated in apoptosis and undergo enzymatic elimination via MnSOD and CuZnSOD with further detoxification via catalase. c-jun-mediated survival was in part dependent on ROS production. c-jun-mediated repression of MnSOD and catalase occurred via mitochondrial complex I and NOX I. Collectively, these studies define a pivotal role of endogenous c-jun in promoting cell survival via maintaining mitochondrial integrity and expression of the key regulators of ROS production. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 202. doi:10.1158/1538-7445.AM2011-202
Cardiac Toxicity of Aerosol Propellants
Authors: Alex Silverglade
Journal: JAMA (1971)

<h3>To the Editor.—</h3> Since the writing of my letter on "Aerosols and Aerosol Propellants in Asthma" (<b>215:</b>118, 1971), two new pieces of information which shed considerable light on the subject have come to my attention. Azar and his colleagues (above) noted one. Additionally, Dollery et al<sup>1</sup>recently reported that measurable amounts of trichloromonofluoromethane ( fluorocarbon 11) were demonstrated in the blood of human subjects. After 30 consecutive inhalations of a Medihaler aerosol propellant within two minutes, the amount of trichloromonofluoromethane in the blood was only one-hundreth of that obtained with halothane during stage three anesthesia. This comparison is signficant since halothane has a chemical structure similar to that of the propellants and the anesthetic agent is known to sensitize the heart to epinephrine. Dichlorodifluoromethane and cryofluorane (fluorocarbon 114) yielded amounts too small to quantify, but were said to be one tenth of the amount of propellant 11. It remains
Regulation of glucose utilization in adipose cells and muscle after long-term experimental hyperinsulinemia in rats.
Authors: L J Wardzala, M Hirshman, E Pofcher, E D Horton, P M Mead, S W Cushman, E S Horton
Journal: Journal of Clinical Investigation (1985)

The effects of chronic insulin administration on the metabolism of isolated adipose cells and muscle were studied. Adipose cells from 2 and 6 wk insulin-treated and control rats, fed either chow or chow plus sucrose, were prepared, and insulin binding, 3-O-methylglucose transport, glucose metabolism, and lipolysis were measured at various insulin concentrations. After 2 wk of treatment, adipose cell size and basal glucose transport and metabolism were unaltered, but insulin-stimulated transport and glucose metabolism were increased two- to threefold when cells were incubated in either 0.1 mM glucose (transport rate limiting) or 10 mM glucose (maximum glucose metabolism). Insulin binding was increased by 30%, but no shift in the insulin dose-response curve for transport or metabolism occurred. After 6 wk of treatment, the effects of hyperinsulinemia on insulin binding and glucose metabolism persisted and were superimposed on the changes in cell function that occurred with increasing cell size in aging rats. Hyperinsulinemia for 2 or 6 wk did not alter basal or epinephrine-stimulated lipolysis in adipose cells or the antilipolytic effect of insulin. In incubated soleus muscle strips, insulin-stimulated glucose metabolism was significantly increased after 2 wk of hyperinsulinemia, but these increases were not observed after 6 wk of treatment. We conclude that 2 wk of continuous hyperinsulinemia results in increased insulin-stimulated glucose metabolism in both adipose cells and soleus muscle. Despite increased insulin binding to adipose cells, no changes in insulin sensitivity were observed in adipose cells or muscle. In adipose cells, the increased glucose utilization resulted from both increased transport (2 wk only) and intracellular glucose metabolism (2 and 6 wk). In muscle, after 2 wk of treatment, both glycogen synthesis and total glucose metabolism were increased. These effects of hyperinsulinemia were lost in muscle after 6 wk of treatment, when compared with sucrose-supplemented controls.