tbuckley/cabot-search huggingface dataset:
Myocarditis of Lupus Erythematosus
Authors: MURRAY A. VARAT
Journal: Annals of Internal Medicine (1979)

Letters and Corrections1 March 1979Myocarditis of Lupus ErythematosusMURRAY A. VARAT, M.D.MURRAY A. VARAT, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-3-438 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The association between lupus myositis and myocarditis reported by Borenstein and co-workers in the November issue (1) is very interesting. I wish to comment on the significance of the serum creatine kinase (CK)-cardiac (MB) isoenzyme elevation in their patient and on their suggestion that CK isoenzyme determination may be of value in the diagnosis of lupus myocarditis.A small amount of CK-MB is found in skeletal muscle by tissue analyses (2). In addition, in healthy control subjects, up to 2% of serum CK may be in the MB form (3). Therefore, the total CK of 1730 U/litre...References1. BORENSTEINFYEARNETTSTEVENS DWFM: The myocarditis of systemic lupus erythematosus. Association with myositis. Ann Intern Med 89(Part 1):619-624, 1978 LinkGoogle Scholar2. YASMINEHIBRAHIMABBASNEZHADAWAD WGME: Isoenzyme distribution of creatine kinase and lactate dehydrogenase in serum and skeletal muscle in Duchenne muscular dystrophy, collagen disease and other muscle disorders. Clin Chem 24:1985-1989, 1978 CrossrefMedlineGoogle Scholar3. VARATMERCER MD: Cardiac specific creatine phosphokinase isoenzyme in the diagnosis of acute myocardial infarction. Circulation 51:855-859, 1975 CrossrefMedlineGoogle Scholar4. AHMEDWILLIAMSONROBERTSCLARKSOBEL SJRRB: The association of increased plasma MB CPK activity and irreversible ischemic myocardial injury in the dog. Circulation 54:187-193, 1976 CrossrefMedlineGoogle Scholar5. BRIGDENBYWATERSLESSOFFROSS WEMJ: The heart in systemic lupus erythematosus. Br Heart J 22:1-16, 1960 CrossrefMedlineGoogle Scholar6. SMITHROGERSMCDANIELTURNERBLACKSTONERACKLEY LWHMEC: Two compartmental models for enzymatic assessment of infarct size. Circulation 58(suppl II):186, 1978 MedlineGoogle Scholar1. BORENSTEINFYEARNETTSTEVENS DWFM: The myocarditis of systemic lupus erythematosus. Association with myositis. Ann Intern Med 89(Part 1):619-624, 1978 LinkGoogle Scholar2. GOTTDIENERSHERBERHAWLEYENGEL JHRW: Cardiac manifestations in polymyositis. Am J Cardiol 41:1141-1149, 1978 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MURRAY A. VARAT, M.D.Affiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPolymyositis—Clinical TrialsDiagnosis of myocarditis 1 March 1979Volume 90, Issue 3Page: 438-439KeywordsCreatine kinaseCreatine kinase MBLupus erythematosusMuscle analysisMuscle tissueMyocarditisMyositisSkeletal muscles ePublished: 1 December 2008 Issue Published: 1 March 1979 PDF downloadLoading ...
Treatment of Rheumatoid Arthritis
Authors: George E. Ehrlich
Journal: JAMA (1974)

THE physical manifestations we call rheumatoid arthritis are relatively easy to diagnose. Unlike the acute diseases that form the main body of most courses in medicine, however, rheumatoid arthritis is not a finite event, not a brief unpleasant interlude in life. Rather, it influences the content of life, to a greater or lesser degree, from its inception onward. The symptoms and signs represent only part of the picture; there are functional and social deficits to consider. Any program of treatment that attempts simply to modify the physical attributes of the disease is doomed to failure. A person afflicted by rheumatoid arthritis sullenly regards a world full of people not so afflicted; he joins a stigmatized minority whose chances of employment, recreational opportunities, insurability, and even access to most public buildings and places of entertainment are severely restricted. Most definitions of rheumatoid arthritis emphasize the chronicity, variable course, idiosyncratic response to
Modern and Traditional Medicine: The Case of Mali
Authors: PASCAL JAMES IMPERATO
Journal: Annals of Internal Medicine (1981)

Abroad1 November 1981Modern and Traditional Medicine: The Case of MaliPASCAL JAMES IMPERATO, M.D.PASCAL JAMES IMPERATO, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-95-5-650 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMali is a large land-locked country in the center of West Africa. It covers 464 873 square miles, about the size of California and Texas combined. Most of the estimated 6.3 million population is in the central and southern regions. The north is desert and semi-desert inhabited by Tuareg and Maure nomads. Ninety percent of the population engage in either subsistence agriculture or animal husbandry. There are over a dozen ethnic groups in the country, but the Mande-speaking peoples—the Bambara, Malinke, and Sarakole—constitute close to 50% of the population (1). French is the official language. Approximately 65% of the population...References1. . Mali Background Notes. Washington, D.C.: U. S. Government Printing Office, 1979:1-5. Google Scholar2. Mali. The Europa Yearbook 1978. London: Europa Publications; 1978:888-96. Google Scholar3. GALLAY H. Trois années d'assistance médicales aux indigènes et de lutte contre la variole. Paris: Larose;1909. Google Scholar4. MACLEAN U. African medical expertise: its transmission and receipt. In: Experts In Africa. Proceedings of a Colloquium at the University of Aberdeen, Aberdeen: Aberdeen University African Studies Group; 1980:114-29. Google Scholar5. IMPERATO P. Traditional medical practitioners among the Bambara of Mali and their role in the modern health care delivery system. Tropical and Geographical Medicine. 1975;27:211-21. MedlineGoogle Scholar6. IMPERATO P. African Folk Medicine. Baltimore: York Press; 1977. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: PASCAL JAMES IMPERATO, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTraditional Medicinal SystemsIn vitro pharmacological effects of Astragalus eremophilus and Melilotus parvifloraTraditional medicine practitioners’ knowledge and views on treatment of pregnant women in three regions of MaliHome management of childhood diarrhoea in southern Mali—Implications for the introduction of zinc treatment 1 November 1981Volume 95, Issue 5Page: 650-651KeywordsTraditional medicine ePublished: 1 December 2008 Issue Published: 1 November 1981 PDF downloadLoading ...
Mycetoma
Authors: Emmett B. Reilly, Howard H. Steel
Journal: New England Journal of Medicine (1949)

MYCETOMA is a chronic granulomatous infection usually involving the feet, rarely affecting the hands1 and still more uncommonly the leg, knee, neck and trunk.2 It is caused by a number of fungi, although the clinical and pathological picture is much the same regardless of etiologic agent. The disease most commonly occurs in males of the working age group with an agricultural background.3 There is no definite racial susceptibility, although certain racial groups, because of their occupational capabilities, are more frequently afflicted.Mycetoma, or Madura foot, if one uses the geographicoanatomic nomenclature, is most prevalent in the warmer climes. The original . . .
At a Loss for Words
Authors: John J Frey
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Scl-86, a marker antigen for diffuse scleroderma.
Authors: W J van Venrooij, S O Stapel, H Houben, W J Habets, C G Kallenberg, E Penner, L B van de Putte
Journal: Journal of Clinical Investigation (1985)

More than 300 sera from patients with a connective tissue disease were analyzed with the immunoblotting technique. The presence of autoantibodies against an 86,000-mol wt marker antigen for diffuse scleroderma (Scl-86) was found in 14 out of 33 patients with scleroderma. The presence of anti-Scl-86 antibodies seemed to correlate with the diagnosis of diffuse scleroderma since they were found in 13 out of 22 diffuse scleroderma patients and in only one out of 11 patients with limited scleroderma. All scleroderma sera (33 patients' sera and 13 reference sera) were also tested for the presence of anti-Scl-70 antibodies. It was found that all anti-Scl-70 positive sera (n = 25) contained anti-Scl-86 antibody as well, suggesting a relationship between these two antigens. However, the Scl-86 antigen was shown to be an extremely insoluble nonchromosomal protein, resistant to boiling in sodium dodecyl sulfate. This contrasts with the Scl-70 antigen, which has been described as a thermolabile, soluble antigen present in the chromatin fraction. Together, our results are consistent with the idea that Scl-70 is a degradation product of Scl-86. The Scl-86 antigen is present in freshly prepared rabbit thymus, spleen, and liver nuclei as well as in nuclei from various cultured cell lines, but is not detectable in extractable nuclear antigen from rabbit thymus. In a limited retrospective study, the anti-Scl-86 antibodies were found in two sera from patients with Raynaud's phenomenon before the development of diffuse scleroderma. Therefore, it is possible that screening of patients' serum for this antibody might predict the development of diffuse scleroderma.
CARBON DIOXID AS AN AID IN GENERAL ANESTHESIA
Authors: JOHN S. LUNDY
Journal: JAMA (1925)

The introduction of ethylene into the field of anesthesia in the early part of 1923 by Luckhardt 1 suggested the need for an enlarged gas machine by which ethylene, nitrous oxid, oxygen, carbon dioxid and ether could be administered. 2 The work of Henderson, Haggard and Coburn 3 and White, 4 showing that carbon dioxid aids in the introduction of ether 5 as well as in its elimination, and that it is also an aid in ethylene anesthesia, 6 prompted me to include a control for carbon dioxid, thus making an apparatus of the four-control type. Some of these machines were the Gwathmey type; others were the Heidbrink type. Attachments for the ordinary gas machine were not satisfactory.  In the cases discussed here, in which the apparatus was used, carbon dioxid was shown to be an aid in gas and in gas-ether anesthesia. The tabulation of cases shows the various
The relationship of psychopathology and hyperhidrosis
Authors: R.A. Ruchinskas, R.K. Narayan, R.J. Meagher, S. Furukawa
Journal: British Journal of Dermatology (2002)

Hyperhidrosis is a common yet poorly understood disease that is often exacerbated by emotional stress. While a psychiatric explanation of causality is frequently offered, there is little evidence to support or reject the view that the condition is primarily an anxiety-based disorder.To quantify objectively the degree of psychopathology in patients with hyperhidrosis.Forty-two patients diagnosed as having hyperhidrosis were examined prior to endoscopic sympathectomies. All patients took the Minnesota Multiphasic Personality Inventory-2 (MMPI-2) and State-Trait Anxiety Inventory (STAI) before surgery. Results were compared with established norms.The group scored well within established norms on both psychometric measures. On scales measuring anxiety, depression and conversion phenomena, 88% of the MMPI-2 profiles lacked elevations, and 86% of the patients lacked elevations on the STAI State and Trait Anxiety scales. Personality variables were not associated with postsurgical outcome.Most individuals suffering from essential hyperhidrosis lack overt psychopathology. While some patients subjectively describe symptoms of anxiety, mild depression and social isolation, these complaints appear often to be in reaction to or superimposed upon an organic disease process and not the primary cause of their condition.
Electromechanical mapping versus positron emission tomography and single photon emission computed tomography for the detection of myocardial viability in patients with ischemic cardiomyopathy
Authors: Henrik Wiggers, Hans Erik Bøtker, Peter Søgaard, Anne Kaltoft, Flemming Hermansen, Won Yong Kim, Lars Krusell, Leif Thuesen
Journal: Journal of the American College of Cardiology (2003)
Longitudinal and Circumferential Strain Rate, Left Ventricular Remodeling, and Prognosis After Myocardial Infarction
Authors: Chung-Lieh Hung, Anil Verma, Hajime Uno, Sung-Hee Shin, Mikhail Bourgoun, Amira H. Hassanein, John J. McMurray, Eric J. Velazquez, Lars Kober, Marc A. Pfeffer, Scott D. Solomon
Journal: Journal of the American College of Cardiology (2010)
Leukemogenic risk of hydroxyurea therapy in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis
Authors: Sucha Nand, Wendy Stock, John Godwin, Susan Gross Fisher
Journal: American Journal of Hematology (1996)

In polycythemia vera (PV), treatment with chlorambucil and radioactive phosphorus (p32) increases the risk of leukemic transformation from 1% to 13–14%. This risk has been estimated to be 1–5.9% with hydroxyurea (HU) therapy. When compared with historical controls, the risk with use of HU does not appear to be statistically significant. The leukemogenic risk of HU therapy in essential thrombocytosis (ET) and in myelofibrosis with myeloid metaplasia (MMM) is unknown. HU remains the main myelotoxic agent in the treatment of PV, ET, and MMM. We studied 64 patients with these three disorders, seen at our institution during 1993–1995. The patients were studied for their clinical characteristics at diagnosis, therapies received, and development of myelodysplasia or acute leukemia (MDS/AL). Forty-two had PV, 15 ET, and 6 MMM, and 1 had an unclassified myeloproliferative disorder. Of the 42 patients with PV, 18 were treated with phlebotomy alone, 16 with HU alone, 2 with p32, 2 with multiple myelotoxic agents, and 2 with interferon-α(IFN-α). Two patients from the phlebotomy-treated group, one from the HU-treated group, and 1 from the multiple myelotoxic agent-treated group developed MDS/AL in the larger group, 11 received no treatment or aspirin alone, 18 were treated with phlebotomy alone, 25 with HU, 5 with multiple myelotoxic agents, 2 with p32, 2 with IFN-α, and 1 with melphalan. Study of the entire group of 64 patients showed that only one additional patient (total of 5 out of 64) developed MDS/AL. This patient had been treated with HU alone. Statistical analysis did not show any association between clinical characteristics at diagnosis, or HU therapy, and development of MDS/AL (P = 0.5). Thus, our data provide no evidence suggestive of increased risk of transformation to MDS/AL with HU therapy in PV, ET, and MMM. Larger, prospective studies are needed to study this issue further. © 1996 Wiley-Liss, Inc.
Physicians for Rural Areas
Authors: Richard A. Berning
Journal: JAMA (1985)

<h3>To the Editor.—</h3> Peter Barna's<sup>1</sup>proposal to match new physician supply with rural demand in exchange for loan forgiveness is well taken by this medical student. I have few resources for aid other than insufficient guaranteed student loans and bank loans, which incur debt very quickly. Unfortunately, I will probably be influenced by this debt in my choice of specialty and practice location (ie, urban) even though I would enjoy working in a small rural community. Working as a volunteer in Appalachia made me aware of the great need for medical care in rural America. However, practicality will most likely replace idealism until my bills are paid. In lieu of the National Health Service Corps Scholarship Program, which is no longer available, I propose that the Preferred Placement Program, now offered to students of the Medical College of Ohio at Toledo, be expanded to a larger regional or even national
Systemic antibody responses to gut microbes in health and disease
Authors: Kathrin Zimmermann, Anna Haas, Annette Oxenius
Journal: Gut Microbes (2012)

Gastrointestinal commensal microbes usually exist in mutualistic relationship with their mammalian host. This relationship exists even though the mammalian host immune system is equipped with exquisite sensors for microbial chemical structures which trigger powerful immune defense mechanisms. Such beneficial mutualism is specifically maintained at the gut mucosal interface by a variety of physical and bioactive barriers as well as specific immunregulatory mechanisms. In addition, there is a strict compartmentalization between systemic and gut mucosal immunity—at least in inbred mice—which focuses adaptive immunity to gut microbes specifically to the gut tissue and the gut lumen. Only in circumstances of increased gut microbial exposure due to elevated gut epithelial permeability, due to genetic deficiencies in local defense mechanisms, due to imbalances in local immune regulation or in case of gastrointestinal pathogenic bacterial infections this compartmentalization is broken and systemic immune responses to gut microbes are induced, which manifest for example as systemic antibody responses specific for gut microbial antigens. Here we briefly discuss the abundance of systemic antibody responses to commensal gut bacteria in healthy humans and how it is altered in situations with chronic enteropathies such as in inflammatory bowel disease and HIV-1 infection or infection with gut bacterial pathogens.
Underneath The Logwood Tree
Authors: G. G. Liddle
Journal: JAMA (1967)

To the Editor:—  Rough calculation yields the figure of 6 billion as the number of aitches ( H )The Journalhas printed as a symbol for the dye hematoxylin in the past 50 years. How many of your intrepid and hardy readers know that this dye is obtained from the logwood tree? And how many can identify a logwood tree on sight?  Traveling recently in Jamaica my curiosity was aroused by passing a Logwood Plantation which turned out to be a commercial logwood farm.  Unknown to the average Yankee, the tree is wholly familiar to the average Jamaican, as a scraggly spiny unkempt nuisance of a tree, good for holding barbed wire when serving as fencepost, with staining of the staple holes by an iron hematoxylin differing only slightly from that of Weigert.  The bark shows circumferential stripes (Fig 1), and the tree with its series of small leaves reminds one
Photopatch testing in photosensitive patients
Authors: H.K. Bell, L.E. Rhodes
Journal: British Journal of Dermatology (2000)

S ir, The British Photodermatology Group (BPG) held a workshop on photopatch testing in November 1995, the findings and recommendations of which were published in the British Journal of Dermatology. 1 A standard series of six potential photoallergens was devised, incorporating agents which were widely used at the time and reported to be a relatively common cause of photocontact allergy. Agents of historical interest such as the antibacterial tetrachlorosalicylanilide, which were no longer clinically relevant, were excluded. From September 1996, we have performed photopatch tests on all patients with suspected photosensitivity who have been referred to the Liverpool Photobiology Unit for diagnostic photoinvestigation; the agents tested and procedure were as recommended by the BPG. 1 We have conducted a retrospective review of the positive results obtained in order to establish which allergens are most often identified as relevant, and in which photosensitive disorders these reactions are occurring. On day 0, the standard series of photocontact allergens ( Table 1) is applied to the patient’s back in duplicate, one set of patches for irradiation and one for control. The minimal erythema responses to ultraviolet (UV) A are also assessed. The patches are removed on the following day, and one set of allergens is irradiated with 5 J/cm2 of broad‐band UVA. Lower doses of radiation are given in those with low erythema thresholds to UVA. The readings are taken 48 h later. Reactions are graded as follows: 0, no response; ±, doubtful response; 1, mild erythema; 2, moderate erythema; 3, erythema and oedema; 4, erythema, oedema and vesicles. Grades 1 and above are regarded as positive reactions.
Does Aquaporin-4–Seronegative Neuromyelitis Optica Exist?
Authors: Michael Levy
Journal: JAMA Neurology (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Tumor-Inhibitory Antibiotic Uptake Facilitated by Leukoregulin: A New Approach to Drug Delivery
Authors: C. H. Evans, P. D. Baker
Journal: JNCI Journal of the National Cancer Institute (1988)

The uptake of tumor-inhibitory antibiotics by human K562 erythroleukemia cells was examined in the presence of leukoregulin to determine if the lymphokine's ability to increase the plasma membrane permeability of tumor cells facilitates concurrent entry of pharmacologically active molecules. K562 cells were exposed to 0.25-2.0 micrograms of doxorubicin/mL for up to 60 minutes at 37 degrees C. Commencing within 15 minutes, leukoregulin increased the entry of doxorubicin approximately twofold and the uptake of mitomycin, mithramycin, and propidium iodide twofold to tenfold. This finding indicates the potential biotherapeutic value of leukoregulin in promoting the selective entry of pharmacologically active molecules into leukoregulin-sensitive target cells.
Changing pattern of in-stent restenosis after intracoronary beta-irradiation: downsizing the lesion
Authors: Christoph K. Naber, Chatchawan Suphatheeratham, Katja Brauck, Tom Oberheiden, Holger Eggebrecht, None Yasser Abdel Rahman, Wolfgang Sauerwein, Raimund Erbel, Dietrich Baumgart
Journal: Journal of the American College of Cardiology (2002)