tbuckley/cabot-search huggingface dataset:
CASES ILLUSTRATIVE OF (1) FRACTURE OF CARPAL SCAPHOID WITH LUXATION OF SEMILUNAR, (2) FRACTURE OF CARPAL SCAPHOID WITH PALPABLE DEFORMITY
Authors: P. G. Skillern
Journal: JAMA (1913)

Close study of injuries about the wrist renders the casual diagnosis of sprain or contusion less and less tenable. I have pictured and described 1 four cases of sprain—or tear-fracture, including one of the wrist, which might readily have been diagnosed and treated as sprain or contusion, but which demanded the same careful immobilization as though gross fractures. So, too, fractures of the bones of the carpus, of which that involving the scaphoid is the commonest, may readily be overlooked owing to their small size and firm ligamentary interunion, factors which mask or withhold the usual signs of fracture. That these fractures can be recognized, that their frequency is greater than statistics indicate, and that many cases of otherwise unaccountable crippled wrist would not occur, these two cases illustrate. They both were seen by me in the surgical out patient department of the University Hospital, service of
DETERMINANTS OF PROCEDURAL FAILURE IN CONTEMPORARY PERCUTANEOUS VASCULAR INTERVENTION: INSIGHTS FROM THE BLUE CROSS BLUE SHIELD OF MICHIGAN CARDIOVASCULAR CONSORTIUM
Authors: Paul Michael Grossman, Khan Munir, Stanley J. Chetcuti, Daniel S. Menees, Thomas P. Davis, Roberto A. Corpus, Steven K. Wang, Arthur Riba, David Share, Hitinder S. Gurm
Journal: Journal of the American College of Cardiology (2010)
Breast-Conserving Surgery Is Preferred Though Not Commonly Performed in an Urban Region of China.
Authors: G. Zhang, R. Lian, R. Yue, G. Wang, X. Liang, J. Gao
Journal: Cancer Research (2009)

Abstract Introduction: Breast-conserving surgery (BCS) followed by radiation therapy has proven to be as effective as modified radical mastectomy, and has, therefore, been considered as the standard treatment for patients with localized breast cancer in Western societies. However, performance of BCS for the treatment of breast cancer in China is not as common as in Western countries. This study was to evaluate healthy women's attitudes towards BCS in an urban region of China.Method: Between February and March 2009, three hundred and fifty healthy women from three urban suburbs of Taiyuan city in Northern China were invited to complete a self-administered questionnaire. Participants' characteristics, including age, education, occupation, and attitudes towards breast cancer treatment options and involvement of treatment decisions, were collected and analyzed.Results: Three hundred and fifteen women returned the questionnaire. The response rate was 90%. The median age of the participants was 31.2 years old (range: 16 – 69 years old). Among them, 49.2% were married, 27.9% had received high levels of education, and 87.3%, 95.2% and 71.4% would like to know the disease status, to involve making treatment decisions, and to accept BCS, respectively, if they were diagnosed with breast cancer. Women aged above 45 years were more likely to choose BCS compared with those less than 45 years old (73.4% vs 61.5%, P = 0.08). There was no association between choices of surgical approaches and levels of education or occupation. As for breast cancer treatment information sources, 76.8% of the participants mentioned oncologists, followed by the internet (12.1%), friends, and media (10.8%). Almost all responders (93.3%) would like to attend hospitals specialized in cancer treatment if breast lumps were detected.Conclusion: Although only 7.1% of breast cancer patients attending a specialized tumor hospital in Taiyuan city underwent BCS, the current study indicate that most women in Northern China would prefer BCS to mastectomy if they were diagnosed with breast cancer. Therefore, further occupational training is warranted for oncologists in China so that optimal treatments for patients with breast cancer can be carried out. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 6077.
MLD according to the WHO classification in AML has no correlation with age and no independent prognostic relevance as analyzed in 1766 patients
Authors: Hannes Wandt, Ulrike Schäkel, Frank Kroschinsky, Gabriele Prange-Krex, Brigitte Mohr, Christian Thiede, Ulrich Pascheberg, Silke Soucek, Markus Schaich, Gerhard Ehninger
Journal: Blood (2007)
Impact of Microvascular Dysfunction on Left Ventricular Remodeling and Long-Term Clinical Outcome After Primary Coronary Angioplasty for Acute Myocardial Infarction
Authors: Leonardo Bolognese, Nazario Carrabba, Guido Parodi, Giovanni M. Santoro, Piergiovanni Buonamici, Giampaolo Cerisano, David Antoniucci
Journal: Circulation (2004)

We hypothesized that preserved microvascular integrity in the area at risk would favorably influence left ventricular (LV) remodeling and long-term outcome after acute myocardial infarction.Before and after successful primary angioplasty (percutaneous transluminal coronary angioplasty [PTCA]), 124 patients with acute myocardial infarction underwent intracoronary myocardial contrast echo (MCE). An MCE score index (MCESI) was derived by averaging the single-segment score (0=not visible, 1=patchy, 2=homogeneous contrast effect) within the area at risk. An MCESI > or =1 was considered adequate reperfusion. Mean follow-up was 46+/-32 months. After PTCA, 100 patients showed adequate reperfusion (no microvascular dysfunction, NoMD), whereas 24 did not (MD). MD patients had a higher mean creatine kinase (4153+/-2422 versus 2743+/-1774 U/L; P=0.002) and baseline wall-motion score index (2.61+/-0.31 versus 2.25+/-0.42; P<0.001) and a lower baseline ejection fraction (33+/-8% versus 40+/-7%; P<0.001). From day 1 on, LV volumes progressively increased in the MD patients (n=19) and were larger than those of NoMD patients (n=85) at 6 months (end-diastolic volume 170+/-55 versus 115+/-29 mL; P<0.001). MCESI was the most important independent predictor of LV dilation (OR 0.61, 95% CI 0.52 to 0.71, P<0.000001). By Cox analysis, MD represented the only predictor of cardiac death (OR 0.26, 95% CI 0.09 to 0.72, P=0.010) and combined events (cardiac death, reinfarction, and heart failure; OR 0.44, 95% CI 0.23 to 0.85, P=0.014). MD patients showed worse survival in terms of cardiac death (P<0.0001) and combined events (P<0.0001).In reperfused acute myocardial infarction, MD within the risk area is an important predictor of both LV remodeling and unfavorable long-term outcome.
Abstract 1625: Curcumin induces expression of 15-hydroxyprostaglandin dehydrogenase in normal gastric mucosa RGM-1 cells: Possible involvement of AP-1
Authors: Ji-Hye Jang, Jong-Min Park, Jeonghwa Woo, Young Wook Lee, Young-Joon Surh, Hye-Kyung Na
Journal: Cancer Research (2012)

Abstract Overproduction of prostaglandin E2 (PGE2) has been reported to be implicated in carcinogenesis. The intracellular level of PGE2 is regulated not only by its biosynthesis, but also by the degradation process. 15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is the key enzyme that catalyzes the first step in the inactivation of PGE2. In the present study, we found that curcumin, a yellow coloring agent present in the rhizome of Curcuma longa Linn (Zingiberaceae), induced expression of 15-PGDH in normal rat gastric mucosa cells (RGM-1) in a concentration and time dependent manners. The mRNA level of 15-PGDH was also increased by curcumin treatment. By using deletion constructs of 15-PGDH promoter, we found that activator protein-1 (AP-1) is the most essential transcription factor responsible for curcumin-induced upregulation of 15-PGDH expression. Curcumin induced phosphorylation of ERK1/2 and JNK1/2, but did not affect activation of p38 MAP kinase. However, treatment with U0126 and SP600125, pharmacological inhibitors of ERK and JNK, respectively failed to suppress the induction of 15-PGDH expression in curcumin-treated RGM-1 cells. Curcumin enhanced the expression of c-Jun, c-Fos and CREB in the nuclear fraction of RGM-1 cells. In contrast, tetrahydrocurcumin which lacks the α,β-unsaturated carbonyl group failed to induce expression 15-PGDH, suggesting that the electrophilic α,β-unsaturated carbonyl group of curcumin plays a critical role in its induction of 15-PGDH expression in RGM-1 cells. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1625. doi:1538-7445.AM2012-1625
Essential fruit, vegetables, and lists for health
Authors: C. McDermott
Journal: BMJ (2014)

We all know that eating fruit and vegetables is good for us, and a study in The BMJ this week adds to the now substantial evidence showing that people who eat more fruit and vegetables are more healthy and less likely to die prematurely. Wang and colleagues ask, “What is the association between consumption of fruit and vegetables and risk of all cause, cardiovascular, and cancer mortality?” ( BMJ 2014;349:g4490, doi:10.1136/bmj.g4490).

Their systematic review and dose-response meta-analysis from 16 prospective cohort studies shows that higher consumption of fruit and vegetables was significantly associated with a lower risk of all cause mortality. They interestingly also observed “a threshold around five servings of fruits and vegetables a day after which the risk of all cause mortality did not reduce further.”

The question of …
An Unusual Unilocular Mesothelial Cyst of the Pleura
Authors: Yoshio Monzen, Hajime Okazaki, Taichi Kurose, Mio Mito, Koichi Wadasaki, Takashi Nishisaka
Journal: Clinical Nuclear Medicine (2011)

A 79-year-old woman was found to have an abnormal shadow on chest radiography. Computed tomography demonstrated a pleural mass. The F-18 fluorodeoxyglucose positron emission tomography (FDG PET) was performed to determine whether the pleural mass was benign or malignant. The histologic examination of the resected mass showed a unilocular mesothelial cyst of the pleura. The FDG PET findings of a mesothelial cyst of the pleura have not yet been previously reported. The FDG PET findings of a mesothelial cyst in the pleura reflected the microscopic findings of the resected mass. The FDG PET findings, therefore, seem to be useful in the diagnosis of mesothelial cysts.
1008 KIDNEY TUBULAR DYSFUNCTION (KTD) IN PATIENTS WITH PROLONGED EXPOSURE TO TENOFOVIR (TDF): A PROSPECTIVE STUDY
Authors: P. Labarga, P. Barreiro, S. Rodriguez-Novoa, E. Vispo, M. Albalate, L. Martín-Carbonero, C. Solera, J. Medrano, F. Blanco, V. Soriano
Journal: Journal of Hepatology (2010)
Chronic Q fever with mixed cryoglobulinaemia.
Authors: H Torley, H Capell, M Timbury, C McCartney
Journal: Annals of the Rheumatic Diseases (1989)

A 47 year old woman presented with a six month history of vasculitic rash, splenomegaly, and cardiac murmurs. Investigations showed the presence of mixed cryoglobulinaemia and raised titres to Coxiella burnetii consistent with chronic Q fever infection. The patient was treated with tetracycline (1 g four times a day).
Measurement of β‐Adrenergic Receptors on Lymphocytes in Normal Subjects and Asthmatics in Relation to β‐Adrenergic Hyperglycaemic Response and Bronchial Responsiveness
Authors: Shinji Motojima, Takeshi Fukuda, Sohei Makino
Journal: Allergy (1983)

The numbers of β‐adrenergic receptors on lymphocytes in normal subjects and asthmatic patients were measured by the use of [ 125 ]hydroxybenzylpindolol. The numbers of β‐adrenergic receptors per lymphocyte in normal subjects, drug‐free asthmatics and patients taking β‐stimulants were 1146±98, 845±114 and 582±47 sites/cell (mean ± SE), respectively. The differences were statistically significant ( P &lt; 0.05) among these groups, while no statistically significant differences were found in dissociation constants. A 42% decrease in the number of β‐adrenergic receptors per lymphocyte after administration of 6 mg/day of terbutaline for 7 days was noted in four volunteers. There was significant correlation ( r = 0.68, P &lt; 0.01) between the number of β‐adrenergic receptors per lymphocyte and the percentage increase in blood sugar 20 min after subcutaneous injection of 4 μg/kg epinephrine. There was also significant correlation ( r = 0.78, P &lt; 0.005) between the number of β‐adrenergic receptors per lymphocyte and the respiratory threshold for acetylcholine. These results suggest that β‐blockade and bronchial hypersensitivity in asthmatic patients may in part be due to a decreased number of β‐adrenergic receptors.
Bezafibrate therapy in patients with isolated low high-density lipoprotein cholesterol levels may have a beneficial effect in prevention of atherosclerosis
Authors: Moshe S. Weintraub, Itamar Grosskopf, Gideon Charach, Ronit Mor, Ardon Rubinstein, Yoram Wollman, Rachel Judevices, Adrian Iaina
Journal: Metabolism (1995)
NEW TRENDS IN HOSPITAL DESIGN
Authors: PAUL HAUN, Z. M. LEBENSOHN
Journal: American Journal of Psychiatry (1948)

The one dominant note motivating our entire thinking on hospital design has been, "How does this or that feature improve the patient-doctor relationship?" We have not thought in terms of handling large numbers on a production line basis. This is best left to the automotive geniuses in Detroit. We have wanted to make our hospitals places where veterans can be treated not only with scientific skill but with human warmth and understanding attention. We have wanted our hospitals to instill a feeling of security and confidence in the patient and thus act as a silent, but ever active, force in therapy. We want our Hospital of the Future to be a "doctor's hospital" or, better still, a "patient's hospital"—not an "administrator's hospital." Psychiatry has made enormous strides in the last 50 years. It now occupies a respected position among the medical disciplines. Psychiatry is no longer relegated to the back wards of forbidding "asylums"—but makes its contribution felt on every ward of the modern hospital. Psychiatry has made great progress; we want its architecture to keep pace.
Policy for early discharge after acute myocardial infarction.
Authors: Y K Lau, J Smith, S L Morrison, D A Chamberlain
Journal: BMJ (1980)

Simple criteria were used to select a low-risk group of patients after acute myocardial infarction. The criteria depended on the presence or absence of diabetes, pulmonary oedema, serious rhythm disorders, and recurrent cardiac pain. Patients in the low-risk category with a suitable home environment were discharged from hospital after five to seven days (mean 6.2 days); they constituted 47% of the 267 hospital survivors over 18 months. Mortality in the selected patients was 2.4% at six weeks and 7% at one year. Most complications preventing early discharge were identified on the first day. Provisional selection for a short hospital stay was made after two days, and 76% of those judged suitable at 48 hours remained free of complications. Early selection of a low-risk category is justifiable and of practical value, though subsequent events will delay discharge for some patients. All patients who died in hospital or within two weeks after infarction had developed overt complications by the end of the fourth day. The results suggest that a policy of hospital discharge after four days would be justifiable for a low-risk group selected by the present criteria.
Extrachromosomal DNA in Human Cancers
Authors: P. V. Schoenlein, M. M. Gottesman
Journal: JNCI Journal of the National Cancer Institute (1990)

Genomic amplification, an increase in gene copy number, is one of the predominant manifestations of the genetic instability that typifies cancer cells (1,2).The resulting increase in the amount of a gene product that is limiting for cell growth may confer a selective growth advantage.In mammalian cells, gene amplification in vivo and in vitro confers resistance to many drugs (3-6) and appears to contribute to the progression of malignancy ( 7).The amplification of oncogenes has been well documented, especially in tumors of neuroectodermal origin, eg, small-cell carcinomas of the lung (8,9), glioblastomas (10,11), retinoblastomas (12), and neuroblastomas (13,14).
Depth and Duration of Cooling for Perinatal Asphyxial Encephalopathy
Authors: Nicola J. Robertson, Neil Marlow
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
STUDIES ON METHODS OF PREVENTION OF EPIDEMIC INFLUENZA
Authors: JOSEPH STOKES
Journal: JAMA (1942)

The control of any epidemic respiratory disease in time of war, when aggregations of individuals are rapidly changing in both position and size, is a challenge to preventive medicine. For such a disease as epidemic influenza, in which possible methods of prevention during peacetime have been gaining a properly controlled momentum, the acceleration required by the war may well advance the consideration of preventive measures which, though evidence is not complete, have sufficient experimental success to warrant trial. Obviously, such trials should include only those measures which from previous experimental observations have the greatest possibility of success and which have at the same time no deleterious effect. Despite the large group of respiratory infections of different etiology which resemble epidemic influenza, it has been possible since 1933 to identify widespread epidemics of influenza type A<sup>1</sup>with some degree of clarity. The virus of influenza type B has been more
Drug Eruption Reference Manual
Authors: Larry E. Millikan
Journal: JAMA (1996)

For many years in Europe, an excellent resource for the evaluation of cutaneous drug reactions has been a book published by Bruinsma, related to the drug reaction reporting services of the European Benelux countries. Reporting of additional and different reactions through a central registry is periodically updated, so this book provides an important resource for European physicians, both in ambulatory care and dermatology, on up-to-date impressions and diagnosis of putative drug reactions. At one time in the United States, the American Academy of Dermatology had, with the Food and Drug Administration, an adverse drug reaction reporting service, which provided a reasonable database, but the service has been discontinued for lack of funding.  More recently, Jerome Litt has taken on much of this effort and has accumulated, over the last several years, an increasingly useful book of lists of probable drug reactions tied in with literature sources. The acronym forDrug
Ethical Issues in Rural Health Care
Authors: Myles N. Sheehan
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hypomorphic mutation in TTC7A causes combined immunodeficiency with mild structural intestinal defects
Authors: Stavroula Woutsas, Caner Aytekin, Elisabeth Salzer, Cecilia Domínguez Conde, Sema Apaydin, Herbert Pichler, Nima Memaran-Dadgar, Ferda Ozbay Hosnut, Elisabeth Förster-Waldl, Susanne Matthes, Wolf-Dietrich Huber, Thomas Lion, Wolfgang Holter, Ivan Bilic, Kaan Boztug
Journal: Blood (2015)
Fundamentals of Immunology
Authors: Irwin Polk
Journal: JAMA (1981)

As a textbook of basic immunology, this presentation is comprehensive and well written. It is well organized and helpfully supplemented by figures and tables, which appear almost one to a page. The references are carefully selected to document and amplify only the essential points and are present in such modest numbers as to be manageable rather than overwhelming. Basic immunology is described completely, beginning at the cellular level and continuing to an overview of the entire immune system. Lacking, however, is a discussion of the genetics of the immune response and phylogeny and ontogeny, which would have put the entire biologic process in better perspective. Missing also is consideration of the clinical application of the immunologic information; accordingly, such topics as replacement therapy, immunomodulation, and drug therapy are not discussed. Thus, while the text is too detailed in its coverage of basic immunology to be used by medical students, it
Influence of UV irradiation on penetration of hydrocortisone. In vivo study in hairless rat skin
Authors: E. LAMAUD, W. SCHALLA
Journal: British Journal of Dermatology (1984)

Journal Article Influence of UV irradiation on penetration of hydrocortisone. In vivo study in hairless rat skin Get access E. LAMAUD, E. LAMAUD Centre International de Recherches Dermatologiques, Sophia Antipolis, 06565 Valbonne Cedex, France Search for other works by this author on: Oxford Academic Google Scholar W. SCHALLA W. SCHALLA Centre International de Recherches Dermatologiques, Sophia Antipolis, 06565 Valbonne Cedex, France Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 111, Issue s27, 1 July 1984, Pages 152–157, https://doi.org/10.1111/j.1365-2133.1984.tb15595.x Published: 01 July 1984