tbuckley/cabot-search huggingface dataset:
The prolonged pressor response to renin in the nephrectomized rat.
Authors: G W Boyd
Journal: Circulation Research (1979)

Angiotension I dose-response curves and renin clearances were studied in nephrectomized and paired sham-nephrectomized control rats under pentobarbital anesthesia. Both threshold and slope of the angiotensin dose-response curves were decreased 22 hours after nephrectomy. In addition, the ratio of renin clearance (determined during renin infusions) in the 22-hour-nephrectomized rat to that in paired 22-hour sham-nephrectomized controls was 0.50 +/- 0.03 (mean +/- SEM, P less than 0.001, n = 12 pairs). The finding of reduced renin clearance was confirmed by an indirect assessment of "effective renin clearance" based on a comparison of the blood pressure decline after renin injections with angiotensin I dose-response curves in the same rat. Overall, approximately half of the 50% fall in renin clearance could be accounted for by an immediate effect of removal of the kidney on renin clearance. This role of the kidney in renin clearance was confirmed by the finding of a renal venous-arterial renin ratio of 0.9 +/- 0.03 (P less than 0.005) during renin infusion in normal rats. It is concluded that both changes in the angiotensin I dose-response curve and decrease in plasma renin clearance contribute to the postnephrectomy prolongation of the renin pressor response in the rat.
Effect of norepinephrine and fluid administration on pulmonary extravascular water volume in dogs.
Authors: J H Ellis, J F Murray
Journal: Circulation Research (1975)

The effects of norepinephrine-induced vasoconstriction on pulmonary extravascular water volume (PEWV) and central volume were studied before and after intravenous volume expansion with 5% dextrose and water (20 ml/kg body weight). PEWV was measured by double isotope dilution and gravimetric analysis and assessed by electron photomicrography. Comparisons were made with saline-treated control dogs. Thirty-six dogs were studied after they had been anesthetized with sodium pentobarbital. PEWV determined by indicator dilution increased during norepinephrine infusion, especially after volume expansion; in contrast, PEWV in control dogs was constant despite similar increases in pulmonary arterial and left atrial pressures. However, measurements of PEWV by gravimetric analysis and inspection of electron photomicrographs failed to reveal extravascular accumulation of water in vasoconstricted dogs. Thus, it was concluded that the increased PEWV measured by indicator dilution in norepinephrine-treated dogs compared with that in saline-treated dogs reflects more complete perfusion of pulmonary capillaries and access of the diffusible indicator to additional lung tissues and spaces. Improved capillary filling presumably is attributable to peripheral vasoconstriction and redistribution of blood into the thorax. PEWV determined by gravimetric analysis in dogs that had had open-chest procedures for lung biopsy and electron photomicrography was significantly less than that in dogs with their chests closed throughout the experiments. Although the mechanism for the water loss in unknown, the difference must be recognized when the results from various types of experiments are compared.
Alcohol and Ventricular Arrhythmia
Authors: HASAN YAZICI
Journal: Annals of Internal Medicine (1973)

Letters, Comments, and Corrections1 January 1973Alcohol and Ventricular ArrhythmiaHASAN YAZICI, M.D.HASAN YAZICI, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-1-153_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The design of the study reported in "Ventricular Arrhythmias Associated with the Ingestion of Alcohol," by Singer and Lundberg (Ann Intern Med77:247-248, 1972), was such that no useful information could have been obtained in the end. The one challenge with alcohol in a single dose after a control period was followed by ventricular premature contractions and ventricular tachycardia. Not attempting to duplicate their finding, the authors proceeded with a different method of alcohol challenge; ingestion of alcohol was done over 1½ hours and under quinidine prophylaxis; no ventricular premature contractions occurred. No alcohol levels are given...Reference1. FRIDERG C: Diseases of the Heart. Philadelphia, W. B. Saunders Co., 1966, p. 1661 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Metabolic Research Unit Creighton University Omaha, Neb. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1973Volume 78, Issue 1Page: 153-153KeywordsAlcoholsArrhythmiaIngestionProphylaxisVentricular tachycardia Issue Published: 1 January 1973 PDF downloadLoading ...
Cutaneous Manifestations of Pentazocine Addiction
Authors: Bard Cosman
Journal: JAMA (1978)

<h3>To the Editor.—</h3> Schiff and Kern, the authors of "Unusual Cutaneous Manifestations of Pentazocine Addiction" (238:1542-1543, 1977), might be interested in knowing of the report of four other cases of pentazocine skin ulcerations.<sup>1</sup>Of interest is the fact that detailed study of pathology sections suggest strongly that the tissue damaged by pentazocine exhibits a specific obliterative vasculitis quite different from the vascular manifestations of other addictive drugs. The clinical finding mentioned by Schiff and Kern—the peculiar woody induration—when taken together with the pathology appears to be pathognomonic for this manifestation of addiction. It is also of interest that all four cases reported in our communication<sup>1</sup>were those of physicians or others intimately associated with health care. The initial belief that pentazocine was nonaddictive and advertising to that effect may have stimulated its use in this population.
The Human Protein Index
Authors: Norman G. Anderson
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Immunohistochemical and ultrastructural features of congenital melanocytic naevus cells support a stem‐cell phenotype
Authors: V.A. Kinsler, G. Anderson, B. Latimer, D. Natarajan, E. Healy, G.E. Moore, N.J. Sebire
Journal: British Journal of Dermatology (2013)

Multiple congenital melanocytic naevi (CMN) in one individual are caused by somatic mosaicism for NRAS mutations; however, the lineage of the mutated cells remains uncertain.To test the hypothesis that CMN may be derived from cutaneous stem cells.Sixty-six CMN samples from 44 patients were stained for immunohistochemical (IHC) markers of melanocytic differentiation (TYR, TRP1, TRP2, LEF1, MITF, cKit), pluripotency (nestin, fascin, CD133, CD20, CD34), monocyte/macrophage lineage (CD68, CD163, CD14), proliferation (Ki67) and MTOR/Wnt-signalling pathway activation (pS6, β-catenin). Semiquantitative scoring compared samples with naevus cell nesting (group 1) with those with only diffuse dermal infiltration (group 2). Transmission electron microscopy (TEM) was performed on 10 samples.A normal melanocyte population was seen overlying many dermal CMN. Group 1 samples were significantly more likely to express melanocytic differentiation markers than group 2, and expression decreased significantly with depth. Expression of these markers was correlated with each other, and with nestin and fascin. CD20 staining was positive in a substantial proportion and was stronger superficially. Expression of β-catenin and pS6 was almost universal. Some samples expressed monocyte/macrophage markers. TEM revealed variable naevus cell morphology, striking macromelanosomes, double cilia and microvilli.Congenital melanocytic naevi development frequently coexists with normal overlying melanocyte development, leading us to hypothesize that in these cases CMN are likely to develop from a cell present in the skin independent of, or remaining after, normal melanocytic migration. IHC and TEM findings are compatible with CMN cells being of cutaneous stem-cell origin, capable of some degree of melanocytic differentiation superficially.
Developmental Changes in Ventricular Diastolic Function Correlate With Changes in Ventricular Myoarchitecture in Normal Mouse Embryos
Authors: Takahiro Ishiwata, Makoto Nakazawa, William T. Pu, Sergei G. Tevosian, Seigo Izumo
Journal: Circulation Research (2003)

Both genetic and epigenetic factors, such as abnormal hemodynamics, affect cardiac morphogenesis and the pathogenesis of congenital heart disease. Diastolic function is an important determinant of cardiac function, and tools for evaluating diastolic function in the embryo would be very valuable for assessment of cardiac performance. Using histological measurements of ventricular myoarchitecture, Doppler assessment of ventricular inflow velocities, and direct measurement of ventricular pressure, we investigated developmental changes of ventricular diastolic function in the mouse embryos from embryonic days 9.5 to 19.5. Regression analysis showed that peak velocity of A wave (an index of passive compliance) correlated with the area of trabecular myocardium in right ventricle (RV) (r2=0.92, P<0.0001) and left ventricle (LV) (r2=0.93, P<0.0001). Peak velocity of E wave (an index of active relaxation) exponentially correlated with the area of compact myocardium in RV (r2=0.98, P<0.0001) and LV (r2=0.97, P<0.0001). We used these techniques to analyze FOG-2 null embryos. FOG-2 null embryos had thin compact myocardium, higher EDP and E/A ratio, smaller -dP/dt, and diminished sucking pressure than wild-type littermates, indicating that decreased ventricular diastolic function might be the primary cause of embryonic lethality. In conclusion, during embryogenesis the development of compact myocardium tightly regulates the development of ventricular distensibility. Our study in normal mice forms the basis for future studies of embryonic cardiac function in genetically manipulated mice with abnormalities of the cardiovascular system.
Aortoiliac Steal — A Cause of Intestinal Ischemia
Authors: Lester F. Williams, Robert M. Kim, William Tompkins, John J. Byrne
Journal: New England Journal of Medicine (1968)

THE third reported case of aortoiliac steal1 , 2 is presented to call attention to this potential complication of surgical correction of aortoiliac occlusion.A 54-year-old man was admitted to the hospital because of gangrenous changes of the 3d, 4th and 5th toes of the left foot. Thirteen years previously lumbar sympathectomy had been performed because of a "cool left foot." One month before admission, claudication, involving the left lower extremity, had developed, followed shortly afterward by a nonhealing traumatic ulcer of the left calf and then by the gangrene of the toes noted above.There was no prior history of coronary . . .
THE PHYSIOLOGY AND PRINCIPAL INTERRELATIONS OF THE THYROID
Authors: David Marine
Journal: JAMA (1935)

<h3>Note.</h3> —This article and the articles in the previous issues ofThe Journalare part of a series published under the auspices of the Council on Pharmacy and Chemistry. Other articles will appear in succeeding issues. When completed, the series will be published in book form.—Ed. The greatest advances in thyroid physiology during the last decade have been made in the chemistry of thyroxine<sup>1</sup>and in the interrelations of the thyroid with other organs both of internal and of external secretion, although in the latter field only a good beginning has as yet been made. The fact that the principal function of the thyroid is to increase oxidative processes in the body further indicates that all body activities are influenced by the state of thyroid function and vice versa. Although the major serious disabilities due to disturbance in thyroid function are known, it is to be expected that as the
Bladders and Brobdingnag
Authors: K. J Turner
Journal: BMJ (2000)

Generations of children will have read abridged versions of Jonathan Swift's Gulliver's Travels (1767). Sadly, if familiarity prevents rereading then much of the richness in this masterpiece will be missed. For example, few will be aware that Gulliver was a surgeon. Educated at Cambridge, Gulliver studied surgery for four years in London, and then studied medicine for two further years. The story of his adventures is peppered with surgical references. In Brobdingnag (a …
Recurrence Rates in Genital Herpes after Symptomatic First-Episode Infection
Authors: Jacqueline Benedetti
Journal: Annals of Internal Medicine (1994)

Objective: To evaluate the frequency of reactivation of genital herpes infection and to identify predictors for recurrence. Design: Prospective, observational cohort study. Setting: Research clinic. Patients: 457 consecutive patients who did not have acute-phase serum antibodies to herpes simplex virus type 2 (HSV-2) but who did have herpes simplex virus (HSV) isolated from genital lesions. Results: Eighty-nine percent of patients with HSV-2 had at least one recurrence during follow-up (median, 391 days); the median monthly recurrence rate was 0.34. Thirty-eight percent had at least 6 recurrences during the first year and 20% had more than 10 recurrences. The median monthly recurrence rate was 0.43 for men and 0.33 for women (difference, 0.10 [95% CI, 0.03 to 0.19]; P < 0.01). Twenty-six percent of women and 8% of men had no or 1 recurrence in year 1 of follow-up, whereas 14% of women and 26% of men had more than 10 recurrences. Patients who had severe primary HSV-2 infection (duration, ≥ 35 days) had recurrences nearly twice as often (0.66 compared with 0.36 recurrences per month [95% CI, 0.18 to 0.57]) and had a shorter time to first recurrence when compared with those who had shorter first episodes. Conclusions: Almost all persons with initially symptomatic HSV-2 infection have symptomatic recurrences. More than 35% of such patients have frequent recurrences. Recurrence rates are especially high in persons with an extended first episode of infection, regardless of whether they receive antiviral chemotherapy with acyclovir. Men with genital HSV-2 infection have about 20% more recurrences than do women, a factor that may contribute to the higher rate of HSV-2 transmission from men to women than from women to men and to the continuing epidemic of genital herpes in the United States.
Caveolin-1 is enriched in the peroxisomal membrane of rat hepatocytes
Authors: Jannes Woudenberg, Krzysztof P. Rembacz, Fiona A. J. van den Heuvel, Titia E. Woudenberg-Vrenken, Manon Buist-Homan, Mariska Geuken, Mark Hoekstra, Leo E. Deelman, Carlos Enrich, Rob H. Henning, Han Moshage, Klaas Nico Faber
Journal: Hepatology (2009)

Caveolae are a subtype of cholesterol-enriched lipid microdomains/rafts that are routinely detected as vesicles pinching off from the plasma membrane. Caveolin-1 is an essential component of caveolae. Hepatic caveolin-1 plays an important role in liver regeneration and lipid metabolism. Expression of caveolin-1 in hepatocytes is relatively low, and it has been suggested to also reside at other subcellular locations than the plasma membrane. Recently, we found that the peroxisomal membrane contains lipid microdomains. Like caveolin-1, hepatic peroxisomes are involved in lipid metabolism. Here, we analyzed the subcellular location of caveolin-1 in rat hepatocytes. The subcellular location of rat hepatocyte caveolin-1 was analyzed by cell fractionation procedures, immunofluorescence, and immuno-electron microscopy. Green fluorescent protein (GFP)-tagged caveolin-1 was expressed in rat hepatocytes. Lipid rafts were characterized after Triton X-100 or Lubrol WX extraction of purified peroxisomes. Fenofibric acid–dependent regulation of caveolin-1 was analyzed. Peroxisome biogenesis was studied in rat hepatocytes after RNA interference–mediated silencing of caveolin-1 and caveolin-1 knockout mice. Cell fractionation and microscopic analyses reveal that caveolin-1 colocalizes with peroxisomal marker proteins (catalase, the 70 kDa peroxisomal membrane protein PMP70, the adrenoleukodystrophy protein ALDP, Pex14p, and the bile acid–coenzyme A:amino acid N-acyltransferase BAAT) in rat hepatocytes. Artificially expressed GFP–caveolin-1 accumulated in catalase-positive organelles. Peroxisomal caveolin-1 is associated with detergent-resistant microdomains. Caveolin-1 expression is strongly repressed by the peroxisome proliferator-activated receptor-α agonist fenofibric acid. Targeting of peroxisomal matrix proteins and peroxisome number and shape were not altered in rat hepatocytes with 70%-80% reduced caveolin-1 levels and in livers of caveolin-1 knockout mice. Conclusion: Caveolin-1 is enriched in peroxisomes of hepatocytes. Caveolin-1 is not required for peroxisome biogenesis, but this unique subcellular location may determine its important role in hepatocyte proliferation and lipid metabolism. (Hepatology 2010.)
236 The role of somatostatin and octreotide in preventing the post endoscopic increase of HVPG in cirrhotics with bleeding varices
Authors: J. Vlachogiannakos, A. Kougioumtzian, C. Triantos, N. Viazis, S. Sgouros, A. Saveriadis, S. Manolakopoulos, C. Markoglou, E. Gouma, T. Economopoulos, S. Raptis
Journal: Journal of Hepatology (2006)
ARSENO-THERAPY IN SYPHILIS, WITH MORE PARTICULAR REFERENCE TO "GALYL."
Authors: J. J. Abraham
Journal: BMJ (1914)

MARCH 14, r1914 case of patients who are unable to afford tlle expense of suclh.-8.That more specialized lectures for practitioners, students, and iurses should be given on venereal diseases, and opportunities for clinical and laboratory researchi REFERENCES.
Effects of oral flecainide and amiodarone on atrial fibrillatory frequency in persistent human atrial fibrillation
Authors: Andreas Bollmann, Karl-Heinz Binias, Ines Toepffer, Reiko Steinert, Jochen Moiling, Sven Reek, Helmut U. Klein, Christoph Geller
Journal: Journal of the American College of Cardiology (2002)
Erich Langer: One Who Came Back
Authors: Walter H. C. Burgdorf, Gerd Plewig, Peter Kohl, Leonard J. Hoenig
Journal: JAMA Dermatology (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Proton secretion by stimulated neutrophils. Significance of hexose monophosphate shunt activity as source of electrons and protons for the respiratory burst.
Authors: N Borregaard, J H Schwartz, A I Tauber
Journal: Journal of Clinical Investigation (1984)

Phagocytosis by neutrophils is accompanied by a burst in O2 consumption and activation of the hexose monophosphate shunt (HMPS). Proton secretion equal to the amount of O2 consumed is an additional feature of the respiratory burst, but its source has not been identified, nor has the source of all electrons donated to O2 in the respiratory burst. We chemically quantitated total CO2 generation in human neutrophils and found that proton secretion elicited by phagocytosis was accompanied by a stoichiometric increase in CO2 generation. Addition of carbonic anhydrase and its inhibitors had no effect on either the quantities of CO2 measured or the quantities of protons secreted. Therefore, the CO2 generated in the respiratory burst of stimulated neutrophils is hydrated to form H2CO3, which then dissociates, accounting for the observed proton secretion. Furthermore, the CO2 generated corresponds to the O2 consumed with a respiratory quotient of nearly 1. We conclude on the basis of this and previous studies that the HMPS activity is the source of both the electrons for the NADPH oxidase and of protons secreted in association with the respiratory burst.
Immunologic characterization of monoclonal antibodies that modulate human IgE binding to the major birch pollen allergen Bet v 1☆, ☆☆, ★, ★★
Authors: S LEBECQUE, C DOLECEK, S LAFFERB, V VISCO, S DENEPOUXA, J PINA, C GURETA, G BOLTZNITULESCU, A WEYER, R VALENTA
Journal: Journal of Allergy and Clinical Immunology (1997)
Study findings on FDA antidepressant warnings and suicide attempts in young people: a false alarm?
Authors: C. Barber, D. Azrael, M. Miller
Journal: BMJ (2014)

We question Lu and colleagues’ findings that the prescription of antidepressants decreased and suicide attempts in young people increased after the Food and Drug Administration released warnings about antidepressant safety for two reasons.1 Firstly, the measure they use as a proxy of suicide attempts (poisonings by psychotropics) is faulty and, secondly, more direct measures of attempts and deaths (figure⇓) show no increase, on balance, …