tbuckley/cabot-search huggingface dataset:
Adhesive Escherichia coli in inflammatory bowel disease and infective diarrhoea.
Authors: D. A. Burke, A. T. Axon
Journal: BMJ (1988)

The clinical features of ulcerative colitis and Crohn's disease are similar to those of infections of the bowel, although their cause is uncertain. Many bacteria that cause intestinal diseases adhere to the gut mucosa, and adhesion of pathogenic Escherichia coli is resistant to D-mannose. The adhesive properties of isolates of E coli were assessed by assay of adhesion to buccal epithelial cells with mannose added. The isolates were obtained from patients with inflammatory bowel diseases (50 with a relapse of ulcerative colitis, nine with ulcerative colitis in remission, 13 with Crohn's disease, and 11 with infectious diarrhoea not due to E coli) and 22 controls. The median index of adhesion to buccal epithelial cells (the proportion of cells with more than 50 adherent bacteria) for E coli from patients with ulcerative colitis in relapse was significantly higher (43%) than that for controls (5%) and patients with infectious diarrhoea (14%). The index was not significantly different among isolates from patients with ulcerative colitis in relapse, Crohn's disease (53%), and ulcerative colitis in remission (30%). If an index of adhesion of greater than 25% is taken as indicating an adhesive strain 86% of isolates of E coli from patients with inflammatory bowel disease were adhesive compared with 27% from patients with infective diarrhoea and none from controls. The adhesive properties of the isolates from patients with inflammatory bowel disease were similar to those of pathogenic intestinal E coli, raising the possibility that they may have a role in the pathogenesis of the condition; the smaller proportion of adhesive isolates in patients with infective diarrhoea due to other bacteria suggests that the organism may be of primary importance rather than arising secondarily.
HLA antigens in patients with scabies
Authors: EDVARD S. FALK, ERIK THORSBY
Journal: British Journal of Dermatology (1981)

Journal Article HLA antigens in patients with scabies Get access EDVARD S. FALK, EDVARD S. FALK Department of Dermatology, University of Tromsø and Tissue Typing Laboratory, National Hospital of Norway, Oslo, Norway Search for other works by this author on: Oxford Academic Google Scholar ERIK THORSBY ERIK THORSBY Department of Dermatology, University of Tromsø and Tissue Typing Laboratory, National Hospital of Norway, Oslo, Norway Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 104, Issue 3, 1 March 1981, Pages 317–320, https://doi.org/10.1111/j.1365-2133.1981.tb00955.x Published: 01 March 1981 Article history Accepted: 30 May 1980 Published: 01 March 1981
The Carcinoid Flush
Authors: Jürgen C. Frölich, Zachary T. Bloomgarden, John A. Oates, James E. McGuigan, David Rabinowitz
Journal: New England Journal of Medicine (1978)

THE carcinoid syndrome is characterized by episodes of flushing that appear to be secondary to the secretion of one or more substances by a tumor of enterochromaffin-cell origin.1 2 3 Flushing can be provoked pharmacologically by the administration of epinephrine,4 isoproterenol,5 ethanol,6 and calcium.7 A number of physiologic stimuli have also been reported to trigger carcinoid flushing, most notably food intake.1 Stimulated by the observation that pentagastrin evoked flushing episodes in two patients with medullary carcinoma of the thyroid (Roberts LJ, McKenna TJ, McLean GW, et al: unpublished data), we considered the possibility that gastrin could act as an endogenous trigger of . . .
Serum procalcitonin as a biomarker differentiating delayed-type drug hypersensitivity from systemic bacterial infection
Authors: Sun-Young Yoon, Seung Hee Baek, Sujeong Kim, Yoon Su Lee, Taehoon Lee, Yun-Jeong Bae, Hyouk-Soo Kwon, Jin Won Huh, Sang-Bum Hong, You Sook Cho, Sail Chun, Chae-Man Lim, Younsuck Koh, Hee-Bom Moon, Tae-Bum Kim
Journal: Journal of Allergy and Clinical Immunology (2013)
Old Friends Among Our Advertisers
Authors: JAMES A. CLIFTON
Journal: Annals of Internal Medicine (1977)

Editorials1 July 1977Old Friends Among Our AdvertisersJAMES A. CLIFTON, M.D., F.A.C.P., EDWARD J. HUTH, M.D., F.A.C.P.JAMES A. CLIFTON, M.D., F.A.C.P.Search for more papers by this author, EDWARD J. HUTH, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-87-1-115 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe editorial above has set forth the importance of advertising in this journal to its subscribers and readers. We call particular attention here to 21 companies that began to advertise in our journal 26 to 50 years ago. They believed when they first came to us that we could offer them an important audience, and they still wish to speak to our readers.To these old friends goes our gratitude on behalf of all readers of this journal, past and present, for this long, constant, and cherished support.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAdvertising Policies of Medical Journals: Conflicts of Interest for Journal Editors and Professional Societies 1 July 1977Volume 87, Issue 1Page: 115-115KeywordsGratitude Issue Published: 1 July 1977 PDF DownloadLoading ...
POSTMORTEM HEPATIC GLYCOGENOLYSIS IN HYPERINSULINISM AND GLYCOGEN DISEASE 1
Authors: H. P. G. Seckel
Journal: Journal of Clinical Investigation (1939)

In 2 adult cases of spontaneous hypoglycemia, the one probably due to pancreatogenic hyper- insulinism (Case 1: carcinoma of the Langerhans islets with liver metastases), the other possibly due
Particulate Air Pollution, Ambulatory Heart Rate Variability, and Cardiac Arrhythmia in Retirement Community Residents with Coronary Artery Disease
Authors: Scott M. Bartell, John Longhurst, Thomas Tjoa, Constantinos Sioutas, Ralph J. Delfino
Journal: Environmental Health Perspectives (2013)

Background: Decreased heart rate variability (HRV) has been associated with future cardiac morbidity and mortality and is often used as a marker of altered cardiac autonomic balance in studies of health effects of airborne particulate matter. Fewer studies have evaluated associations between air pollutants and cardiac arrhythmia.Objectives: We examined relationships between cardiac arrhythmias, HRV, and exposures to airborne particulate matter.Methods: We measured HRV and arrhythmia with ambulatory electrocardiograms in a cohort panel study for up to 235 hr per participant among 50 nonsmokers with coronary artery disease who were ≥ 71 years of age and living in four retirement communities in the Los Angeles, California, Air Basin. Exposures included hourly outdoor gases, hourly traffic-related and secondary organic aerosol markers, and daily size-fractionated particle mass. We used repeated measures analyses, adjusting for actigraph-derived physical activity and heart rate, temperature, day of week, season, and community location.Results: Ventricular tachycardia was significantly increased in association with increases in markers of traffic-related particles, secondary organic carbon, and ozone. Few consistent associations were observed for supraventricular tachycardia. Particulates were significantly associated with decreased ambulatory HRV only in the 20 participants using ACE (angiotensin I–converting enzyme) inhibitors.Conclusions: Although these data support the hypothesis that particulate exposures may increase the risk of ventricular tachycardia for elderly people with coronary artery disease, HRV was not associated with exposure in most of our participants. These results are consistent with previous findings in this cohort for systemic inflammation, blood pressure, and ST segment depression.Citation: Bartell SM, Longhurst J, Tjoa T, Sioutas C, Delfino RJ. 2013. Particulate air pollution, ambulatory heart rate variability, and cardiac arrhythmia in retirement community residents with coronary artery disease. Environ Health Perspect 121:1135–1141; http://dx.doi.org/10.1289/ehp.1205914
Motor responses of the small intestine to intraluminal distension in normal volunteers and a patient with visceral neuropathy.
Authors: G P Kendall, D G Thompson, S J Day
Journal: Gut (1987)

<h3>Abstract</h3> A widespread application of three-dimensional (3D) bioprinting in basic and translational research requires the accessibility to affordable printers able to produce physiologically relevant tissue models. To facilitate the use of bioprinting as a standard technique in biology, an open-source device based on a consumer-grade 3D stereolithographic (SL) printer was developed. This SL bioprinter can produce complex constructs that preserve cell viability and recapitulate the physiology of tissues. The detailed documentation of the modifications apported to the printer as well as a throughout performance analysis allow for a straightforward adoption of the device in other labs and its customization for specific applications. Given the low cost, several modified bioprinters could be simultaneously operated for a highly parallelized tissue production. To showcase the capability of the bioprinter, we produced constructs consisting of patient-derived cholangiocarcinoma organoids encapsulated in a gelatin methacrylate (GelMA)/polyethylene glycol diacrylate (PEGDA) hydrogel. A thorough characterization of different GelMA/PEGDA ratios revealed that the mechanical properties of the bioprinted tumor model can be accurately fine-tuned to mimic a specific tumor micro-environment. Immunofluorescence and gene expression analyses of tumor markers confirmed that the bioprinted synthetic hydrogel provides a flexible and adequate replacement of animal-derived reconstituted extracellular matrix.
Life expectancy in children with cerebral palsy
Authors: R. K Eyman, H. J Grossman, T. L Call, R. H Chaney
Journal: BMJ (1995)

EDITOR,—In their paper on life expectancy in children with cerebral palsy1 Jane L Hutton and colleagues remark on our findings in two selected studies,2 3 stating that our subjects with developmental disability seemed to have a much shorter life expectancy than they found. We studied people who had devastating learning disabilities as well as people with less severe disabilities. Some groups had a very poor prognosis—that is, those who were immobile, could not roll over, were tube fed, had …
ALOPECIA FROM CYVERINE HYDROCHLORIDE
Authors: Oscar L. Levin
Journal: JAMA (1942)

Our purpose in this paper is to report the occurrence of alopecia following the use of a new antispasmodic drug. In this case, the defluvium followed the daily ingestion, for thirty days, of cyverine hydrochloride (Stearns) and rapidly progressed to involve the entire scalp. <h3>REPORT OF CASE</h3><h3>History. —</h3> A white woman aged 49 was seen in consultation on June 6, 1941, complaining of an extreme degree of falling out of the hair of ten days' duration. She gave a history of spasmodic pain in the lower part of the abdomen for the previous three months, for which she had been under the care of her family physician. During this period, several examinations including roentgen ray and proctologic studies of the intestinal tract disclosed no abnormalities, and the diagnosis of a functional intestinal disorder was made. On April 24 the patient was instructed to take cyverine hydrochloride (Stearns), an antispasmodic,
Sulfation of Lithocholate as a Possible Modifier of Chenodeoxycholic Acid-induced Elevations of Serum Transaminase in Patients with Gallstones
Authors: J. W. Marks, S. O. Sue, B. J. Pearlman, G. G. Bonorris, P. Varady, J. M. Lachin, L. J. Schoenfield
Journal: Journal of Clinical Investigation (1981)

Chenodeoxycholic acid (CDC), through its metabolite, lithocholic acid (LC), is hepatotoxic in certain species. The cause of elevations of serum transaminase in 25% of humans ingesting CDC, however, is unknown, but also may be due to LC. Because efficient hepatic sulfation of LC may protect against hepatic injury, the aim of this study was to determine if sulfation of LC might modify CDC-induced elevations of transaminase. Pretreatment sulfation fraction (SF) was estimated in 63 randomly selected patients with gallstones in a double-blind randomized trial of CDC, 750 mg/d, 375 mg/d, or placebo; in 27 of these, SF was repeated at 1 or 2 yr. In four other patients, the SF was measured at 2 yr only. Serum glutamic oxaloacetic transaminase and serum glutamic pyruvic transaminase were determined monthly for 3 mo and then every 3 or 4 mo; an elevation of transaminase was defined as > 150% of the normal upper limit in asymptomatic patients. 10 μCi of 3H-glyco-LC (sp act 84 mCi/mol) was ingested 10-12 h before fasting duodenal biliary drainage. Bile acids in bile were separated by thin-layer chromatography. The SF was estimated as a percentage of total radioactivity (scintillation counting) in sulfated glyco-LC. The standard deviation for replicate SF determinations (n = 311) was 2.1% The pretreatment SF (mean 60.7±1.7 SEM) correlated inversely with age (r = 0.336, P < 0.005) and directly with the obesity index (r = 0.495, P > 0.001), but was independent of sex. The SF, remeasured at 1 or 2 yr, did not change significantly with time or CDC. Among CDC-treated patients, elevations of transaminase occurred in 75% of patients with a SF < 45% vs. 11% with a SF > 45% (P < 0.001). In conclusion, a SF < 45% occurred in patients with gallstones who had a high probability of developing elevated serum transaminase when treated with CDC. Thus, sulfation of lithocholate may modify CDC-induced elevations of serum transaminase.
Pulmonary involvement in sle.
Authors: F Arnalich, S Ruiz de Andres, A Gil, J Garcia Puig, J Barbado, J J Vazquez
Journal: Annals of the Rheumatic Diseases (1980)

ling the causes, achieving prevention, and managing many arthritic disorders require a rigorous biomechanical approach.Man is not entirely a series of immunoglobulins, but possesses more than 300 CorrespondencePulmonary involvement in SLE Sir, Grennan et al.1 recently reported in 22 patients with systemic lupus erythematosus (5 with respiratory symptoms), a restrictive ventilatory defect or reduction in diffusing capacity for CO.Their paper is interesting but we should like to make a few comments: (a) Only 3 tests of lung function were
LIMITATIONS OF CHOLECYSTOGRAPHY WITH WHICH PHYSICIANS SHOULD BE FAMILIAR
Authors: GEORGE B. EUSTERMAN
Journal: JAMA (1928)

Cholecystography represents a distinct contribution to medicine for which the profession is greatly indebted to Graham and his co-workers.<sup>1</sup>This method of roentgen-ray diagnosis of disease of the gallbladder has now been in use for three years and is undoubtedly the best existing single laboratory test. Internists have welcomed it, since they appreciate the superiority of visualized methods of diagnosis. It has been hoped that cholecystography might be in the diagnosis of cholecystic disease what fluoroscopy or serial roentgenography is in the diagnosis of lesions of the upper digestive tract and colon. I fear, however, that this will not be the case since the gallbladder is not as readily accessible to inspection and since there are various unsolved physiologic phenomena that have a direct bearing on the test. One sees a similar parallelism in tests of function of the liver and kidneys. Tests of renal function are more reliable,
Haemoglobin O in An Arab Family
Authors: B. Ramot, S. Fisher, D. Remez, R. Schneerson, D. Kahane, J. A. M. Ager, H. Lehmann
Journal: BMJ (1960)

An 8-year-old Arab boy from the village of Gaser A'zarka, in Israel, was admitted to the paediatric service of Chedera General Hospital, and found to be suffering from a left-lower-lobe pneumonia.The patient was said to have had attacks of abdominal pain about once every -year.mainly in the right hypochondrium.These attacks were accompanied by jaundice and dark urine.Several days before admission such an attack had occurred.On physical examination the boy was pale and jaundiced.In addition to the finding of pneumonia, an enlarged spleen was palpable 4 cm.below the costal margin. Blood Examinationfrom the haemoglobin S fraction and which moved more slowly than S and faster than haemoglobin C (Fig. 2).Comparison with haemoglobin S + E samples showed that the slowest fraction was faster than E and therefore in the position of haemoglobin 0 (Lie-Injo Luan Eng and Sadono, 1958).Direct comparison with -Line of Application C-A.
Alexithymia and Psychological Distress among Frequent Attendance Patients in Health Care
Authors: Matti Joukamaa, Hasse Karlsson, Britta Sohlman, Ville Lehtinen
Journal: Psychotherapy and Psychosomatics (1996)

Background: The aim of the present study was to find out whether alexithymia is common in frequently attending primary health care patients and whether alexithymia and psychological distress are associated in these patients. Methods: Alexithymia was measured by the TAS-26 and psychological distress by the SCL-25 in a random sample of 394 working-age primary health care patients. Frequent attendance was defined as a minimum of 11 visits during 1 year to different kinds of outpatient health care services, excluding specialized psychiatric care. Results: Frequently attending patients with psychological distress were found to be alexithymic more commonly than other patients, but this was not the case with other frequently attending patients. In other words, frequent attendance and alexithymia had an association mediated by psychological distress. Conclusions: There is a subgroup of frequently attending patients, who are alexithymic and have psychological distress, too. They usually visit health-care services because of a somatic complaint. We hypothesize that their expression of psychological distress was masked and somatized just because of alexithymia.
Reduced post-infarction myocardial apoptosis in women: A clue to their different clinical course?
Authors: Giuseppe G. Biondi-Zoccai, Antonio Abbate, Rossana Bussani, Debora Camilot, Maria-Pia Di Marino, Alessandro Petrolini, Luigi M. Biasucci, Alfonso Baldi
Journal: Journal of the American College of Cardiology (2003)
Dermatomyositis responding to treatment of associated toxoplasmosis
Authors: C. C. HARLAND, J. R. MARSDEN, S. A. VERNON, B. R. ALLEN
Journal: British Journal of Dermatology (1991)

We report a 59-year-old woman with severe dermatomyositis in association with high serum toxoplasma antibody titres who was successfully treated with pyrimethamine and sulphadiazine. This case supports an aetiological role for toxoplasmosis in the pathogenesis of some cases of dermatomyositis.
Hemoglobin Beth Israel
Authors: Ronald L. Nagel, Joshua Lynfield, Joyce Johnson, Leon Landau, Robert M. Bookchin, Michael B. Harris
Journal: New England Journal of Medicine (1976)

We found that an abnormal hemoglobin with a very low oxygen affinity was responsible for overt cyanosis in an otherwise healthy adolescent. Hemoglobin Beth Israel, in which serine replaces the asparagine residue normally present at position 102 (G4) of the beta-polypeptide chain, was associated with normal blood counts and no apparent exercise intolerance in the heterozygous carrier. Cyanosis resulted from a drastically right-shifted oxygen dissociation curve, whose position and shape could account for the absence of "physiologic" anemia. The whole-blood oxygen tension at 50 per cent oxygen saturation was 88 mm Hg (normally 26 +/- 1 mm Hg), and the arterial blood was only 63 per cent saturated with oxygen despite a normal oxygen tension of 97 mm Hg. The hemolysate showed a low oxygen affinity but normal Bohr effect. Unexplained cyanosis, particularly in association with normal arterial oxygen tension should prompt a search for an abnormal hemoglobin, which may obviate the need for invasive diagnostic procedures.
Surgery of the Stomach, Duodenum, Gallbladder, and Bile Ducts
Authors: Claude E. Welch, Ronald A. Malt
Journal: New England Journal of Medicine (1987)

OUR last report on progress in abdominal surgery appeared here three years ago.1 In this report, we will confine our discussion to surgery of the stomach, duodenum, and biliary system, focusing on controversial questions. Since we have tried to keep the number of references to a minimum, our opinions sometimes appear without supporting evidence.Stomach and DuodenumGastroesophageal RefluxThe great majority of operations for esophageal reflux now use an abdominal approach, and the Nissen fundoplication continues to be the favorite procedure. The most important feature of a successful repair is restoration of the pressure exerted by the lower esophageal . . .
University budgets and medical education
Authors: L. W Wale
Journal: BMJ (1981)

TABLE I-Pattern of disease in patients with superficial tumours No of recurrences Category of patient No followed Deaths from more than 5 years 1 1 -2 bladder cancer Patients without residual or recurrent tumour at 3 months 33 20 3 10 1 (3°o) Patients with residual or recurrent tumour at 3 months 38 0 3 35 9 (24%O)
Epidemiological study of the relation between arthritis of the hip and hip fractures.
Authors: R G Cumming, R J Klineberg
Journal: Annals of the Rheumatic Diseases (1993)

To clarify the nature of the relation between hip fractures and osteoarthritis.The study was a population based case-control study conducted in Sydney, Australia. Four hundred and sixteen men and women aged 65 years and over were recruited (209 cases, 207 controls). The presence of osteoarthritis was based on self reported pain, swelling, or stiffness of joints in the past year.Among 189 subjects aged 65 to 79 years, but not in older subjects, there was an inverse relation between self reported arthritis in any joint(s) and risk of hip fracture: the age and gender adjusted odds ratio was 0.52 (95% confidence interval 0.27 to 0.98). The prevalence of self reported arthritis of the hip was much lower in patients with hip fracture (4%) than in controls randomly selected from the community (13%); the age and gender adjusted odds ratio was 0.33 (95% confidence interval 0.15 to 0.74). There was also an inverse association between the number of joints reported to be affected by arthritis and risk of hip fracture. These associations were not explained by differences between cases and controls in body mass index or physical activity.The findings of this study support the hypothesis that there is a causal association between osteoarthritis and osteoporosis of the hip.
Patient assessment of treatment following knee injury.
Authors: W G Kernohan, F J Dodd, K E Dowey, L A McConnell
Journal: British Journal of Sports Medicine (1993)

A survey of 100 sports-injured cases was carried out to elicit patients' personal assessment of their treatment and to investigate the utility of a typical database system for recording and analysis. The cases were limited to knee injuries, with a high proportion arising from football of various types and interesting light was thrown on several possible contributory factors.
HOMOLOGOUS AND HETEROLOGOUS PROTECTION IN MICE VACCINATED WITH THE TWO TYPES OF MOUSE TYPHOID BACILLUS
Authors: Ida W. Pritchett
Journal: The Journal of Experimental Medicine (1924)

A saline vaccine prepared from our stock strain of M. T. II produces in mice definite protection against the homologous strain, and perhaps some slight cross-protection against M. T. I also. Two vaccines prepared with our stock strain of M. T. I failed to produce any definite protection in mice even against the homologous strain, nor was any cross-protection afforded against M. T. II.